LOCUS       DAVHSO010000001        97131 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.001, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000001 DAVHSO010000000
VERSION     DAVHSO010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 97131)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 97131)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..97131
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.001"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            71..1348
                     /locus_tag="VVR18_000001"
     CDS             71..1348
                     /locus_tag="VVR18_000001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6031614.1"
                     /translation="MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKT
                     VESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGLENVSPELETVAKLKDKEAVT
                     GEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEE
                     LAKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFT
                     DYESSQTLLGNSEAQVSAARFYVENPKEMDGLMKQVENLALENQGYQVEKENKAFEQI
                     KDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGILLALGKGKSSIFLQF
                     CLEVVLVSLGALLPAFVAGNGITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAE
                     SYVFLVLLSCLSVALCFLFLFRKSPKEILSSIS"
     gene            1361..2008
                     /gene="vex2"
                     /locus_tag="VVR18_000002"
     CDS             1361..2008
                     /gene="vex2"
                     /locus_tag="VVR18_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding subunit Vex2"
                     /protein_id="HEU6031615.1"
                     /translation="MTLLQLQDVTYRYKNTAEAVLYQIDYNFEPGKFYSIIGESGAGK
                     STLLSLLAGLDSPVEGSILFQGEDIRKKGYSYHRMHHISLVFQNYNLIDYLSPLENIQ
                     LVNKKASKDTLLELGLDESQIKRNVLQLSGGQQQRVAIARSLVSEAPVILADEPTGNL
                     DPKTAGDIVELLKSLAQKTGKCVIVVTHSKEVAQASDITLELKDKKLTETRNTSK"
     gene            2060..3439
                     /gene="vex3"
                     /locus_tag="VVR18_000003"
     CDS             2060..3439
                     /gene="vex3"
                     /locus_tag="VVR18_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit Vex3"
                     /protein_id="HEU6031616.1"
                     /translation="MLHNAFAYVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKAS
                     QETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKITENKAIESYVKRINAIGDLT
                     GYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDK
                     DKILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTY
                     SQELYENTAITDIHTAAKLYGYTEDTAIYGDATFFVTADKNLDDVMKELNGISGINWK
                     SYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALLLSLWINARRKEVGIL
                     LSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASK
                     AAQASNLGGGAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQ
                     PKELLLDGE"
     gene            3615..3701
                     /gene="pep27"
                     /locus_tag="VVR18_000004"
     CDS             3615..3701
                     /gene="pep27"
                     /locus_tag="VVR18_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_198523890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative autolysis signal peptide Pep27"
                     /protein_id="HEU6031617.1"
                     /translation="MYEKGFHNVLSSGQLLTDKRPARDYNRK"
     gene            3750..4406
                     /gene="vncR"
                     /locus_tag="VVR18_000005"
     CDS             3750..4406
                     /gene="vncR"
                     /locus_tag="VVR18_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor VncR"
                     /protein_id="HEU6031618.1"
                     /translation="MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYE
                     VALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPF
                     SLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
                     KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
                     "
     gene            4403..5731
                     /gene="vncS"
                     /locus_tag="VVR18_000006"
     CDS             4403..5731
                     /gene="vncS"
                     /locus_tag="VVR18_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase VncS"
                     /protein_id="HEU6031619.1"
                     /translation="MKRTGLFTKIFIYTFSIFSVLVICLHLAIYFLFPSTYLSHRQET
                     IGQKATAIAQSLEGKDRQSIEQVLDLYSQTSDIKGTVKGEMTEDKLEVKDSLPLDTDR
                     QTTSLFIEEREVKTQDGGTMILQFLASMDLQKEAEQISLQFLPYTLLASFLISLLVAY
                     IYARTIVAPILEIKRVTRRMMDLDSQVRLRVDSKDEIGNLKEQINSLYQHLLTVIADL
                     HEKNEAILQLEKMKVEFLRGASHELKTPLASLKILIENMRENIGRYKDRDQYLGVALG
                     IVDELNHHVLQILSLSSVQELRDDRETIDLLQMTQNLVKDYALLAKERELQIDNSLTH
                     QQAYLNPSVMKLILSNLISNAIKHSVPGGLVRIGEREGELFIENSCSSEEQEKLAQSF
                     SDNASRKVKGSGMGLFVVKSLLEHEKLAYRFEMEENRLTFFIDFPKVVQD"
     gene            5872..6753
                     /locus_tag="VVR18_000007"
     CDS             5872..6753
                     /locus_tag="VVR18_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-bisphosphate aldolase"
                     /protein_id="HEU6031620.1"
                     /translation="MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAP
                     VLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTS
                     IMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
                     AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQI
                     QAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAI
                     QASVEERIDVFGSEGKA"
     gene            complement(7074..8264)
                     /locus_tag="VVR18_000008"
     CDS             complement(7074..8264)
                     /locus_tag="VVR18_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="HEU6031621.1"
                     /translation="MKSVKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFIL
                     ATRLPLLESWFHGLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGNLAIYI
                     FASIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRLLTFNLLSFLVGSY
                     ALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTREIQIHLCRPFNYQSGQFAFLK
                     IFQEGFESAPHPFSISGGHGQTLYFTVKNSGDHTNNIYDNLQAGSKVTLDRAYGHMII
                     EEGRENQVWIAGGIGITPFISYIREHPILDKQVHFYYSFRGDENAVYLDLLRNYAQKN
                     PNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEG
                     FKFK"
     gene            complement(8559..9218)
                     /locus_tag="VVR18_000009"
     CDS             complement(8559..9218)
                     /locus_tag="VVR18_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6031622.1"
                     /translation="MESILEILTPDNLVFIFKGFGLTLYISLIAIILSTIIGTVLAVM
                     RNGKNPILRIISSIYIEFVHNVPNLLWIFTIFLVFKMKSTPAGITAFTLFTSAALAEI
                     IRGGLNAVDKGQYKAGMSQGFTSAQILYYIILPQASRKMLPAIISQFVTVIKDTSLLY
                     SVIALQELFGASQILMGRYFEPEQVFSLYILIALIYFSFNLAISSLSHMLAKRWQQAA
                     E"
     gene            complement(9228..9905)
                     /locus_tag="VVR18_000010"
     CDS             complement(9228..9905)
                     /locus_tag="VVR18_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6031623.1"
                     /translation="MTDLSSWTAYFQDFEQFFNGFLFTLALAIGSFILAMVLGIFFGA
                     MSTSKRPILRILARIFVEFYQNTPLLVQFVIVFYGLPLISDHIIMIPIYWTAVLCVGL
                     YHGAYIAEVIRSGIQSIPSGQMEAALSQGFTYISAMRLITLPQAFRIILPPLTNQIVN
                     LIKNTSTVAIISGVDLMFVTKSWSALNGNYIPAFLGAALLYFALCFPVAQFGRKMEQA
                     NKKAYSL"
     gene            complement(9918..10682)
                     /locus_tag="VVR18_000011"
     CDS             complement(9918..10682)
                     /locus_tag="VVR18_000011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEU6031624.1"
                     /translation="MISLFGLAAAKPVQADTSIADIQKRGELVVGVKQDVPNFGYKDP
                     KTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIATFTITDERKK
                     LYNFTSPYYTDASGFLVNKSAKIKKIEDLNGKTIGVAQGSITQRLITELGKKKGLTFK
                     FVELGSYPELITSLHAHRIDAFSVDRSILSGYTNKRTALLDDSFKPSDYGIVTKKSNT
                     ELNDYLDNLVTKWSKDGSLQKLYDRYKLKPSSHTAD"
     gene            complement(10722..11480)
                     /locus_tag="VVR18_000012"
     CDS             complement(10722..11480)
                     /locus_tag="VVR18_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU6031625.1"
                     /translation="MALVEFKNVEKYYGDYHALRNINLRFEKGQVVVLLGPSGSGKST
                     LIRTINGLEAVDKGSLLVNGHQVAGASQKDLVPLRKEVGMVFQHFNLYPHKTVLENVT
                     LSPIKVLGIDKKEAEKTAQKYLEFVNIWDKKDSYPAMLSGGQKQRIAIARGLAMHPEL
                     LLFDEPTSALDPETIGDVLAVMQKLAHDGMNMIIVTHEIGFAREVADRIIFMADGEVL
                     VDTTDVDNFFDNPSKPRAQQFLSKIINHESDKVK"
     gene            11757..13979
                     /gene="recJ"
                     /locus_tag="VVR18_000013"
     CDS             11757..13979
                     /gene="recJ"
                     /locus_tag="VVR18_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HEU6031626.1"
                     /translation="MITPTYEWQFALQVEDADFTKIAKKAGLGPEVARLLFERGIQDQ
                     ESLKKFLEPSLEYLHDAYLLHDMDKAVERIRQAIEEGENILVYGDYDADGMTSASIVK
                     ESLEQLGAECRVYLPNRFTDGYGPNASVYKYFIEQEGISLIVTVDNGVAGHEAIALAQ
                     SMGVDVIVTDHHSMPETLPDAYAIVHPEHPDADYPFKYLAGCGVAFKLACALLEEVQV
                     ELLDLVAIGTIADMVSLTDENRILVQYGLEMLGHTQRIGLQEMLDMAGIAANEVTEET
                     VGFQIAPRLNALGRLDDPNPAIDLLTGFDDEEAHEIALMIHQKNEERKEIVQSIYEEA
                     KTMVDPEKKVQVLAKEGWNPGVLGIVTGRLLEELGQTVIVLNIEDGRAKGSARSVEAV
                     DIFEALDPHRDLFIAFGGHAGAAGMTLEVEQLSDLSQVLEDYVREKGADAGGKNKLNL
                     DEELDLEALSLETVKSFERLAPFGMDNQKPIFYIKNFQVESARTMGAGNAHLKLKISK
                     GEASFEVVAFGQGRWATEFSQTKNLELAVKLSVNQWNGQTALQLMMVDARVEGVQLFN
                     IRGKNAVLPEGVPVLDFPGELPNLAASEAVVVKNIPEDITQLKTIFQEQHFSAVYFKN
                     DIDKAYYLTGYGTRDQFAKLYKTIYQFPEFDIRYKLKDLAAYLNIQQILLVKMIQVFE
                     ELGFVTIKDGVMTVNKEAPKREIGESQIYQNLKQTVKDQEMMALGTVQEIYDFLMEKE
                     "
     gene            14154..15815
                     /locus_tag="VVR18_000014"
     CDS             14154..15815
                     /locus_tag="VVR18_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEU6031627.1"
                     /translation="MSNISLTTLGGVRENGKNMYIAEIGESIFVLNVGLKYPENEQLG
                     VDVVIPNMDYLFENSDRIAGVFLTHGHADAIGALPYLLAEAKVPVFGSELTIELAKLF
                     VKGNDAVKKFNDFHVIDENTEIDFGGTVVSFFPTTYSVPESLGIVLKTSEGSIVYTGD
                     FKFDQTASESYATDFARLAEIGRDGVLALLSDSANADSNIQVASESEVRDEITQTIAD
                     WEGRIIVAAVSSNLSRIQQIFDAADKTGRRIVLTGFDIENIVRTAIRLKKLSLANEIL
                     LIKPKDMSRFEDHELIILETGRMGEPINGLRKMSIGRHRYVEIKDGDLVYIATAPSIA
                     KEAFVARVENMIYQAGGVVKLITQSLHVSGHGNVRDLQLMINLLQPKYLFPVQGEYRE
                     LDAHAKAAMAVGMLPERIFIPKKGTTMAYENGDFVPAGSVSAGDILIDGNAIGDVGNV
                     VLRDRKVLSEDGIFIVAITVNRREKKIVARARVHTRGFVYLKKSRDILRESSELINQT
                     VEDYLQGDDFDWADLKGKVRDNLTKYLFDQTKRRPAILPVVMEAK"
     gene            15884..16663
                     /locus_tag="VVR18_000015"
     CDS             15884..16663
                     /locus_tag="VVR18_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HEU6031628.1"
                     /translation="MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECEDIPVLYLLH
                     GMSGNHNSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQVLK
                     RFFPNMTSKREKIFIAGLSMGGYGCFKLALTTNRFSHAASFSGALSFQNFSPESQNLG
                     SPAYWRGVFGEIRDWTTSPYSLESLAKKSDKKTKLWAWCGEQDFLYEANNLAVKNLKK
                     LGFDVTYSHSAGTHEWYYWEKQLEVFLTTLPIDFKLEERLT"
     gene            16775..17995
                     /gene="murM"
                     /locus_tag="VVR18_000016"
     CDS             16775..17995
                     /gene="murM"
                     /locus_tag="VVR18_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurM"
                     /protein_id="HEU6031629.1"
                     /translation="MYRYQIGIPTLEYDQFVKEHELANVLQSSAWEEVKSNWQHEKFG
                     VYREEKLLATASILIRTLPLGYKMFYIPRGPILDYGDKELLNFAIQSIKSYARSKRAV
                     FVTFDPSICLSQSLINQEKTEFPENLAIIDSLQQMGVRWSGKTEEMGDTIQPRIQAKI
                     YKENFEEDKLSKSTKQAIRTARNKGLEIQYGGLELLDSFSELMKKTEKRKEIHLRNEA
                     YYKKLLDNFKDKAYITLATLDVSKRSQELEEQLAKNRSLEETFTESTRTSKVEAQKKE
                     KERLLEELTFLQEYIDVGQARVPLAATLSLEFGTTSVNIYAGMDDDFKRYNAPILTWY
                     ETARYAFERGMVWQNLGGVENSLNGGLYHFKEKFNPTIEEYLGEFTMPTHPLYPLLRL
                     ALDFRKTLRKKHRK"
     gene            18000..19232
                     /gene="murN"
                     /locus_tag="VVR18_000017"
     CDS             18000..19232
                     /gene="murN"
                     /locus_tag="VVR18_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurN"
                     /protein_id="HEU6031630.1"
                     /translation="MALTTLTKEEFQTYSDQVSSRSFMQSVQMGDLLEKRGARIVYLA
                     LKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELL
                     VKPYETYQTFDSQGNPIDAEKKSIIQDLTDLGYQFDGLTTGYPGGEPDWLYYKDLTEL
                     TEKSLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEY
                     YEHFYDTFGEQAEFLIASLNFSDYMSKLQGEQNKLEENLDKLRLDLSKNPHSEKKQNQ
                     LREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKF
                     YAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFCYH
                     PSPLKYKAIQLLKKIVGR"
     gene            19311..20012
                     /locus_tag="VVR18_000018"
     CDS             19311..20012
                     /locus_tag="VVR18_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="matrixin family metalloprotease"
                     /protein_id="HEU6031631.1"
                     /translation="MRWLFRLIGAFFSFVWRLFWRLVWIVVLLCVLAFGLLWYLNGDF
                     QGALKQAERSVKIGQQSIDQWEKTGQLPKLSQTDSHQHSEGRWAQASARIYLDPQMDS
                     RFQEAYLEAIQNWNQTGAFNFELVTESSKADITATEMNDGGTPVAGEAESQTNLLTGQ
                     FLSVTVRLNHYYLSNPYYGYSYERLVHTAEHELGHAIGLDHTDEKSVMQPAGSFYGIQ
                     EEDVANLRKIYETSE"
     gene            20051..21895
                     /gene="uvrC"
                     /locus_tag="VVR18_000019"
     CDS             20051..21895
                     /gene="uvrC"
                     /locus_tag="VVR18_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HEU6031632.1"
                     /translation="MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSY
                     FRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFI
                     KITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
                     YYHIGQCMAHTICKKDEAYFKSMAQEVSDFLKGHDDKIIDDLKSKMAVAAQSMEFERA
                     AEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNL
                     FPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDSKILKPQRGEKK
                     QLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGT
                     SPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLI
                     VIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEF
                     FLLQRIQDEAHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMKHFKSLTKIKEA
                     SVDEIVEVGVPRVVAEAVQRKLNPQGEALPQVAEERVDYQTEGNHNKP"
     gene            21885..22718
                     /locus_tag="VVR18_000020"
     CDS             21885..22718
                     /locus_tag="VVR18_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HEU6031633.1"
                     /translation="MNHKIAILSDIHGNVTALEAVIADAKNQGVSEYWLLGDIFLPGP
                     GANDLVALLKDLPITASVRGNWDDRVLEALDGQYGLEDPQEVQLLRMTQYLMERMDPA
                     TIVWLRSLPLLEKKEIDGLRFSISHNLPDKNYGGDLLVENDTEKFDQLLDAETDVAVY
                     GHVHKQLLRYGSQGQQIINPGSIGMPYFNWEALKNHRAQYAVIEVEDGELVNILFRKV
                     AYDYEAELEFAKSKGLPFIEMYEELRREDNYQRHNLELLASLIEKHRYVEDVKNFFDF
                     L"
     gene            complement(22900..23700)
                     /locus_tag="VVR18_000021"
     CDS             complement(22900..23700)
                     /locus_tag="VVR18_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6031634.1"
                     /translation="MKKFSLLLAILPFLVACGNQATPKESSSQKTIVVATAGDVPPFD
                     YEDKGNLTGFDIEVLKAVDEKLSDYEIQFQRTAWESIFPGLDSGHYQAAANNLSYTKE
                     RAEKYLYSLPISNNPLVLVSNKKNPLTSLDQIAGKTTQEDTGTSNAQFINNWNQKHTD
                     NPATIDFSGEDIGKRILDLANGEFDFLVFDKVSVQKIIKDRGLDLSVVDLPSTDSPSN
                     YIVFSSDQKEFKEKFDKALKELYQDGTLEKLSNTYLGGSYLPDQSQLQ"
     gene            23871..24476
                     /locus_tag="VVR18_000022"
     CDS             23871..24476
                     /locus_tag="VVR18_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002924506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HEU6031635.1"
                     /translation="MKFLELNKKRHATKHFTDKPVDPKDVRTAIEIATLAPSAHNSQP
                     WKFVVVREKNAELAKLAYGSNFEQVSSAPVTIALFTDTDLAKRARKIARVGGANNFSE
                     EQLQYFMKNLPAEFARYSEQQVSDYLALNAGLVAMNLVLALTDQGIGSNIILGFDKSK
                     VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEIIEKR"
     gene            24489..25889
                     /gene="pepV"
                     /locus_tag="VVR18_000023"
     CDS             24489..25889
                     /gene="pepV"
                     /locus_tag="VVR18_000023"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HEU6031636.1"
                     /translation="MIAIDFTAEVEKRKEDLLADLFSLLEINSERDDSKADAQHPFGP
                     GPVKALEKFLEIADRDGYPTKNVDNYAGHFEFGDGEEVLGIFAHMDVVPAGSGWDTDP
                     YTPTIKDGRLYARGASDDKGPTTACYYGLKIIKELGLPTSKKVRFIVGTDEESGWADM
                     DYYFEHVGLAKPDFGFSPDAEFPIINGEKGNITEYLHFAGENTGAARLHSFTGGLREN
                     MVPESATAVVSGDLTDLQAKLDAFVAEHKLRGELQEEAGQYKVTIIGKSAHGAMPASG
                     VNGATYLALFLSQFGFAGPAKDYLDIAGKILLNDHEGENLKIAHVDEKMGALSMNAGV
                     FRFDETSADNTIALNIRYPKGTSPEQIKSILENLPVASVSLSEHGHTPHYVPMEDPLV
                     QTLLNVYEKQTGLKGHEQVIGGGTFGRLLERGVAYGAMFPDSIDTMHQANEFIALDDL
                     FRAAAIYAEAIYELIK"
     gene            25943..26521
                     /locus_tag="VVR18_000024"
     CDS             25943..26521
                     /locus_tag="VVR18_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HEU6031637.1"
                     /translation="MSQIERIKQAIMADSQNASYTERGIEPLFAAPKTARINIIGQAP
                     GLKTQEAGLYWKDKSGDRLRDWLGVDEDTFYNSGYFAVLPMDFYFPGHGKSGDLPPRT
                     GFAEKWHPQLLQELPDIQLTLLIGQYAQAYYLQEKISGKVTERVKHYKDYLPAYFPLV
                     HPSPRNQIWMAKNPWFEAEVVPDLKKRIKTIL"
     gene            26681..26833
                     /locus_tag="VVR18_000025"
     CDS             26681..26833
                     /locus_tag="VVR18_000025"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU6031638.1"
                     /translation="MKEIAFDAFYQLYQNDQFSLVDVREVDEFAALHLEGAYNLPLSQ
                     LADSYD"
     gene            26876..26968
                     /locus_tag="VVR18_000026"
     CDS             26876..26968
                     /locus_tag="VVR18_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU6031639.1"
                     /translation="MRSARACQFLLEQGYNVINVQGGMLAFEEL"
     gene            27139..28464
                     /gene="brnQ"
                     /locus_tag="VVR18_000027"
     CDS             27139..28464
                     /gene="brnQ"
                     /locus_tag="VVR18_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HEU6031640.1"
                     /translation="MAKKGTLTGLLLFGIFFGAGNLIFPPSLGALSGEHFLPAIAGFV
                     FSGVGIAVLTLIIGTLNPKGYIYEISTKIAPWFATLYLSVLYLSIGPFFATPRTATTA
                     YEVGISPLLSDANKGLGLIVFTVLYFAAAYLISLNPSKILDRIGRILTPVFAILIVIL
                     VVLGAIKYGGTSPQAASAAYQASAFGTGFLEGYNTLDALASVAFSVIAVQTLKQLGFS
                     SKKEYISTIWVVGIVVALAFSALYIGLGFLGNHFPVPAEAMKGGTPGVYILSQATQEI
                     FGSTAQLFLAAMVTVTCFTTTVGLIVSTAEFFNERFPQISYKVYATAFTLIGFAIANL
                     GLDAIIKYSIPVLVILYPITIAIVMIVIVNKFVALSKPGMQLTIAVVTVIAIASVLGS
                     SFKVEFLANLVSVLPFAKASLPWLVPAIVGILLSLVLPNKQESDVFEME"
     gene            28562..29599
                     /locus_tag="VVR18_000028"
     CDS             28562..29599
                     /locus_tag="VVR18_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HEU6031641.1"
                     /translation="MNQTVNYIKELTAIASPTGFTREISEYLVHTLEELGYQPVRTAK
                     GGVNVTIKGQNDEQHRYVTAHVDTLGAIVRAVKPDGRLKLDRIGGFPWNMIEGENCTV
                     HVASTGKTVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDEKVTNEKETRALGIEVG
                     DFISFDPRTVVTETGFIKSRHLDDKVSAAILLNLLRVYKEEGIDLPMTTHFAFSVFEE
                     VGHGANSNIPEEVVEYLAVDMGAMGDDQQTDEYTVSICVKDASGPYHYDFRQHLVALA
                     KEQDIPFKLDIYPFYGSDASAAMSAGAEVKHALLGAGIESSHSYERTHIDSVVATERM
                     VDAYLKSEAVS"
     gene            29601..30062
                     /locus_tag="VVR18_000029"
     CDS             29601..30062
                     /locus_tag="VVR18_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEU6031642.1"
                     /translation="MCLICQRIELIKAGENPYFVKELETGYVVIGDHQYFKGYTLFLA
                     KEHVTELHQMENSVKLRFLEEMSLVQEAVAKAFEAEKMNIELLGNGDAHAHWHLFPRR
                     AGDMKGHGLNGRGPVWWVPWEEMAAEDCQVQSPEREEMIKILSHELEKHLA"
     gene            30080..30796
                     /locus_tag="VVR18_000030"
     CDS             30080..30796
                     /locus_tag="VVR18_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="HEU6031643.1"
                     /translation="MKKRYVILSGLLALTLAACSQEKTKVEENTQKTEQSSQPEGTVG
                     SKSQASSQKKAEVSNKGSYYSIQGKYDEIILANKRYPLSKDYNPGENPTAKAELLKLI
                     AAMQAAGYPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYSEHQTGLAFD
                     VIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEI
                     AASGLSLEEYYGFEGGDYVD"
     gene            complement(30899..30979)
                     /locus_tag="VVR18_000031"
                     /pseudo
     CDS             complement(30899..30979)
                     /locus_tag="VVR18_000031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            31105..31530
                     /gene="rplK"
                     /locus_tag="VVR18_000032"
     CDS             31105..31530
                     /gene="rplK"
                     /locus_tag="VVR18_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004226069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HEU6031644.1"
                     /translation="MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNA
                     RTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTR
                     AQVQEIAETKMPDLNAANVESAMRMIEGTARSMGFTVVD"
     gene            31738..32427
                     /gene="rplA"
                     /locus_tag="VVR18_000033"
     CDS             31738..32427
                     /gene="rplA"
                     /locus_tag="VVR18_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HEU6031645.1"
                     /translation="MAKKSKQLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEV
                     AYNLNIDVKKADQQIRGAMVLPNGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVA
                     KINDGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGK
                     ITYRADRAGNVQAIIGKVSFEAEKLVENFKAFNETIQKAKPATAKGTYVTNLTITTTQ
                     GVGIKVDVNSL"
     gene            32805..32963
                     /locus_tag="VVR18_000034"
                     /pseudo
     CDS             32805..32963
                     /locus_tag="VVR18_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
     gene            complement(33190..33264)
                     /locus_tag="VVR18_000035"
                     /pseudo
     CDS             complement(33190..33264)
                     /locus_tag="VVR18_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829418.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            33422..33640
                     /locus_tag="VVR18_000036"
     CDS             33422..33640
                     /locus_tag="VVR18_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001859328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-export chaperone SecB"
                     /protein_id="HEU6031646.1"
                     /translation="MKKISVTVIGYFEINIDENITDILYVNGTAILYPYLRSIVSIVS
                     AIDSSEAMLLPTINVLELLDKSQPFEEE"
     gene            complement(34168..34245)
                     /locus_tag="VVR18_000037"
                     /pseudo
     CDS             complement(34168..34245)
                     /locus_tag="VVR18_000037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            34316..34972
                     /locus_tag="VVR18_000038"
     CDS             34316..34972
                     /locus_tag="VVR18_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001141648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HEU6031647.1"
                     /translation="MPTALGYVSIGLACGTIGAPYVTPVEMGLMSLFVYAGSAQFAML
                     ALIVVQAPVAAIAMTVFLINLRLFLLSLHASTYFRHTSLWYNIGMSSILTDETYGVLM
                     GELAHTDKVNPMWMHGNNLNSYVAWFVGTVVGTALGGLLPNPEIFGLDFALVGMFIGI
                     FASQFQMMQRRIPVRNLLIILAVVAVSFFLLLTVVSQSLAVLFAMLLGCSMGVVLDGQ
                     "
     gene            34962..35171
                     /locus_tag="VVR18_000039"
     CDS             34962..35171
                     /locus_tag="VVR18_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000253940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HEU6031648.1"
                     /translation="MVSKYLLLAVIFSGLVTWIPRMIPFILVKYKGLPTIVERFLKFL
                     PVSIIFALILSSVVTGKVGNLPPIK"
     gene            35389..36219
                     /locus_tag="VVR18_000040"
     CDS             35389..36219
                     /locus_tag="VVR18_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6031649.1"
                     /translation="MKKIVKYSSLAALGLVAAGVLAACSGGAKKEGEAASKKEIIVAT
                     NGSPKPFIYEENGELTGYEIEVVRAIFKDSDKYNVKFEKTEWSGVFAGLDADRYNMAV
                     NNLSYTKERAEKYLYAAPIAQNPNVLVVKKDDSSIKSLDDIGGKSTEVVQATTSAKQL
                     EAYNAEHTDNPTILNYTKADFQQIMVRLSDGQFDYKIFDKIGVETVIKNQGLDNLKVI
                     ELPSDQQPYVYPLLAQGQDELKSFVDKRIKELYKDGTLEKLSKQFFGDTYLPAEADIK
                     "
     gene            36373..37227
                     /locus_tag="VVR18_000041"
     CDS             36373..37227
                     /locus_tag="VVR18_000041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000694494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HEU6031650.1"
                     /translation="MKIKKWLGLAALATVAGLALAACGNSEKKADNATTIKIATVNRS
                     GSEEKRWDKIQELVKKDGITLEFTEFTDYSQPNKATADGEVDLNAFQHYNFLNNWNKE
                     NGKDLVAIGDTYISPIRLYSGLNGSANKYTKVEDIPANGEIAVPNDATNESRALYLLQ
                     SAGLIKLDVSGTALATVANIKENPKNLKITELDASQTARSLSSVDAAVVNNTFVTEAK
                     LDYKKALFKEQADENSKQWYNIIVAKKDWETSPKADAIKKVIAAYHTDDVKKVIEETS
                     DGLDQPVW"
     gene            37327..38700
                     /locus_tag="VVR18_000042"
     CDS             37327..38700
                     /locus_tag="VVR18_000042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HEU6031651.1"
                     /translation="MVFPSEQEQIEKFEKDHVAQHYFEVLRTLISKKSVFAQQVGLKE
                     VANYLGEIFKRVGAEVEIDESYTAPFVMAHFKSSRPDAKTLIFYNHYDTVPADGDQVW
                     TEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQHHDDLPVNISFIMEGAEESA
                     STDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNKGIVTFDAKVKSADVDIH
                     SSYGGVVESAPWYLLQALQSLRAADGRILVEGLYEEVQEPNEREMALLETYGQRNPEE
                     VSRIYGLELPLLQEERMAFLKRFFFEPALNIEGIQSGYQGQGVKTILPAEASAKLEVR
                     LVPGLEPHDVLEKIRKQLDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYP
                     QGVSVLPTTAGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVE
                     ELIRSYE"
     gene            38693..39754
                     /locus_tag="VVR18_000043"
     CDS             38693..39754
                     /locus_tag="VVR18_000043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HEU6031652.1"
                     /translation="MSRDIIKLDQIDVTFHQKKRTITAVKDVTIHIQEGDIYGIVGYS
                     GAGKSTLVRVINLLQKPSAGKITIDDDVIFDGKVTLTAEQLRRKRQDIGMIFQHFNLM
                     SQKTAEENVAFALKHSGLSKEEKKAKVAKLLDLVGLADRAENYPSQLSGGQKQRVAIA
                     RALANDPKILISDESTSALDPKTTKQILALLQDLNQKLGLTVVLITHEMQIVKDIANR
                     VAVMQDGHLIEEGSVLEIFSNPKQPLTQDFISTATGIDEAMVKIEKQEIVEHLSENSL
                     LVQLKYAGASTDEPLLNELYKHYQVMANILYGNIEILDGTPVGELVVVLSGEKAALAG
                     AQEAILQAGVQLKVLKGVQ"
     gene            39756..40448
                     /locus_tag="VVR18_000044"
     CDS             39756..40448
                     /locus_tag="VVR18_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6031653.1"
                     /translation="MESLIQTYLPNVYKMGWAGQAGWGTAIYLTLYMTVLSFIIGGFL
                     GLVAGLFLVLTAPGGVLENKVVFWILDKTTSIFRAVPFIILLAILSPLSHLIVKTSIG
                     PNAALVPLSFAVFAFFARQVQVVLAELDGGVIEAAQASGATFWDIVGVYLSEGLPDLI
                     RVTTVTLISLVGETAMAGAVGAGGIGNVAIAYGFNRYNHDVTILATIIIILIIFAIQF
                     LGDFLTKKLSHK"
     gene            complement(40478..41047)
                     /locus_tag="VVR18_000045"
     CDS             complement(40478..41047)
                     /locus_tag="VVR18_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEU6031654.1"
                     /translation="MKKSILTTLLFAVLYFLCMGIGVLLGNLFDQTGNMFYAPAFTAL
                     VGGSVYMILVAKVPRFGAITTIGLVIALFFLGTKHGAGSFLPGIICGLLADEVAHLGK
                     YKDKTKNFLSFIIFAFSTTGPILLMWIAPKAYMATLLARGKSQEYIDRIMVAPNPGTV
                     LLFIASIVIGALVGALIGQALSKKFAQKI"
     gene            41182..41796
                     /locus_tag="VVR18_000046"
     CDS             41182..41796
                     /locus_tag="VVR18_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000532354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEU6031655.1"
                     /translation="MGRFLDFVFNRFFLGMIATAFFWLLTLAGGIILGLAPASATLMS
                     LYAEHGYSFREYSLKEAWSLYKQNFVSSNLIFYSFLGVGLVLTYGLYLLVQLPHQTIV
                     HLIATLLNVLVVALIFLAYTVSLKLQVYFALSYRNSLKLSLIGIFMSLAAVAKVLLGT
                     VLLVAIGYYMPALLFFVGIGMWHFFISDMLEPVYEIIHEKLATK"
     gene            41798..43444
                     /locus_tag="VVR18_000047"
     CDS             41798..43444
                     /locus_tag="VVR18_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU6031656.1"
                     /translation="MKHFWLHTLLRTYSSVMIIIIASFAILLSYADWDSREKEAQRVA
                     QRVTARTVSEIEYYHRESTQIAQALVENQARIEGIYKYFSLSMPDYFYWQLERKASPY
                     ISVSLYENVDDLYVRNDFVTGVAIAFQDYKEVYVSTKDKRSGEKIRAEDFKPAGNSFA
                     IPVSDPVSDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDK
                     ESENWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLTLRQTFANY
                     QKQVVDLVDSIQAIAQGQEGLRIDTLEKDQELLLIAETTNDMLDRLEKNIHDIYQLEL
                     SQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERE
                     TLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVD
                     HRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQKYFEHQASYSDQRQ
                     SIGIINVHERFVLYFGDRYAITIESAEQAGVQYRITIQDE"
     gene            43456..44742
                     /locus_tag="VVR18_000048"
     CDS             43456..44742
                     /locus_tag="VVR18_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6031657.1"
                     /translation="MYKVLLVDDEYMVTEGLKRLIPFDKWDMEVVATASHADEALEYV
                     QENPVDVIISDVNMPDKTGLDMIREMKEILPDAAYILLSGYQEFDYVKRAMNLSVVDY
                     LVKPVDKVELGNLLEKIAGQLGERGKKSQTLSQELDEAGFVSYLGDKENWWIGLSKEK
                     QGSFTIPYYVLGQDWQIFISDQPLDGLVVTPFEAPYQEHFERWKLNAEKTLFYGSVNL
                     QQSESLFAYYEPIYRVIIQGNLNQIVEELNLLEKVVLENTPRVPITKQLFIQFVMDVF
                     HLFEHLKADDLTDIVKTIHAIQSFDELVPYIKETLSSFFGQYRMNENVASVLEVIGRD
                     YQKELSLKDISKALFINPVYLGQLIKRETDSTFAELLNKQRIKAAQQLLLSTSDSIED
                     ICYAVGYSNLGYFYKVFRKLCGKSPKAYRKQVETIL"
     gene            44803..45336
                     /locus_tag="VVR18_000049"
     CDS             44803..45336
                     /locus_tag="VVR18_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000729030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6031658.1"
                     /translation="MKKKPIYLWVLLILSALISVPSLFGIVSPLPSKEALRAAQKQVA
                     GVNAQQLEDQLNYTYRVAEASHSIFNVALIVLSTILVVVAIVFLVRKNLQYANYTYVG
                     YVLLAIIGSIYGYVGLQDAVQLVQDESMRLTVSIGSKAVSIFYIVINVLFLALVFYKM
                     WRQQKALAEEEETEELT"
     gene            45414..45884
                     /gene="nrdI"
                     /locus_tag="VVR18_000050"
     CDS             45414..45884
                     /gene="nrdI"
                     /locus_tag="VVR18_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HEU6031659.1"
                     /translation="MKTISLVYISLSGNTESFVTRLKDYLLSQYKGIEVQKIHIKDLV
                     KEGKNFYEMDHPYVAFLPTYLEGGNGVDNGDVEILTTPVGDFIAYGNNASKCFGVVGS
                     GNRNFNNQYCLTAKQYSQRFGFPVLADFEMRGMLEDIKHVAAIIADLYELEKEN"
     gene            complement(46177..47439)
                     /locus_tag="VVR18_000051"
     CDS             complement(46177..47439)
                     /locus_tag="VVR18_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divalent metal cation transporter"
                     /protein_id="HEU6031660.1"
                     /translation="MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGS
                     YGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKLYLWIFFILNVFSAM
                     VNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSA
                     LTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWS
                     AEKRKTVNFNTEDALFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQF
                     VGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLN
                     IWMTITAIIGIIIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWL
                     KHLAIAGLIFLFGFAIFFIYALAIGKAG"
     gene            complement(47749..48207)
                     /locus_tag="VVR18_000052"
     CDS             complement(47749..48207)
                     /locus_tag="VVR18_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3021 domain-containing protein"
                     /protein_id="HEU6031661.1"
                     /translation="MKKQVFHDAAAGVLIGLILSILFSLIYAPNTYAPLNPYSLIGQV
                     MDQHQVHGALVLLYCTLIWAAIGMLFNFGNCLFSRDWSMLRATLTHFFLMLAGFVPLA
                     TLAGWFPFHWIFYLQLIIEFAIVYLIIWAILYKREAKKVDHINQLLEHRK"
     gene            complement(48204..48644)
                     /locus_tag="VVR18_000053"
     CDS             complement(48204..48644)
                     /locus_tag="VVR18_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000861967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6031662.1"
                     /translation="MKVELQISETYEEEKLIVQAPQETEKVQKVIEFAENLDQREKIK
                     GKIDDQVYLVEIGKIQRFYIENRKVLAETTSQTYSIDLRLYQVLKLLPSNFIQISQSE
                     IINIDSISHLKLTPNGLVEIFLKNESFTYSSRRYLKTIKEKLEL"
     gene            49000..50949
                     /gene="mutL"
                     /locus_tag="VVR18_000054"
     CDS             49000..50949
                     /gene="mutL"
                     /locus_tag="VVR18_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HEU6031663.1"
                     /translation="MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQII
                     IEIEEAGLKKVQITDNGYGISHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPS
                     IASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
                     MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSA
                     KKMIAIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKL
                     MVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPD
                     ALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLT
                     LFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELE
                     FFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFP
                     ADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTK
                     EVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHF
                     TKSDMEKMFRRIQENHTSLRELGKY"
     gene            complement(51274..51741)
                     /locus_tag="VVR18_000055"
     CDS             complement(51274..51741)
                     /locus_tag="VVR18_000055"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HEU6031664.1"
                     /translation="MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVN
                     EKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQ
                     ISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA"
     gene            complement(51742..52947)
                     /locus_tag="VVR18_000056"
     CDS             complement(51742..52947)
                     /locus_tag="VVR18_000056"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HEU6031665.1"
                     /translation="MEYRKIQEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTEN
                     VNFMATYAKGLICMPMSESLANQLMLSPMVENNTDNHKTAFTVSIDYKETTTGISAEE
                     RGLTARMCVAEDITPSDFRRPGHMFPLIAKKGGVLERSGHTEATVDLLKLAGLKECGL
                     CCEIMNHDGKMMRTDDLIQFSKKHNIPLITIKELQEYRKVYDQLVERVSTVNMPTRYG
                     NFKAISYIDKLNGEHHLALIMGNIEDEANVLCRVHSECLTGDVLGSLRCDCGQQFDKA
                     MKMIVENGSGVLLYLRQEGRGIGLINKLKAYHLQDQGMDTLDANLALGFEGDLREYHI
                     GAQMLKDLGLQSLHLLTNNPDKVEQLEKYGITISSRISIEIEANPYDSFYLETKKNRM
                     GHILNMEEK"
     gene            complement(52967..53602)
                     /gene="ribE"
                     /locus_tag="VVR18_000057"
     CDS             complement(52967..53602)
                     /gene="ribE"
                     /locus_tag="VVR18_000057"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HEU6031666.1"
                     /translation="MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVN
                     GICLTVTHFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSINGRLGGHVVTGHI
                     DGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKVSKVNFSVSVI
                     PHTLEQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSEISKELLYQNGF"
     gene            complement(53587..54687)
                     /gene="ribD"
                     /locus_tag="VVR18_000058"
     CDS             complement(53587..54687)
                     /gene="ribD"
                     /locus_tag="VVR18_000058"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HEU6031667.1"
                     /translation="MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHE
                     FFGGPHAERNALKNCRESPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLD
                     CNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMSMDGK
                     IATKTNQSKWITEEEARKHVHQLRHHVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRII
                     CDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSS
                     LMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISL
                     PNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE"
     regulatory      complement(54820..54934)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            55091..55684
                     /gene="ruvA"
                     /locus_tag="VVR18_000059"
     CDS             55091..55684
                     /gene="ruvA"
                     /locus_tag="VVR18_000059"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000271492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HEU6031668.1"
                     /translation="MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQED
                     QIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIE
                     TKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDDLPAKVAVQASAENQELEEAMEAM
                     LALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK"
     gene            55694..56257
                     /locus_tag="VVR18_000060"
     CDS             55694..56257
                     /locus_tag="VVR18_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase I"
                     /protein_id="HEU6031669.1"
                     /translation="MTKRCSWVKMTNPLYIAYHDEEWGQPLHDDQALFELLCMETYQA
                     GLSWETVLNKRQAFREAFHSYQIHSVAEMTDTELEAILENPAIIRNRAKIFATRANAQ
                     AFLQLQAEYGSFDAYLWSFVEGKTVVNDVPDYRQAPAKTPLSEKLAKDLKKRGFKFTG
                     PVAVLSFLQAAGLVDDHENDCEWRGLK"
     gene            56254..56931
                     /locus_tag="VVR18_000061"
     CDS             56254..56931
                     /locus_tag="VVR18_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000987430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6031670.1"
                     /translation="MMSNKNKGILIFAILYTVLFVFDGVKLLASLMPSVIANYLVYVV
                     LALYGSFLFKDRLIQQWKEIRKTKRKFFFGVLTGWLFLILMTVVFEFVSEMLKQFVGL
                     DGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLPGLLSIILV
                     GLVFALTHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLII
                     LAISIVK"
     gene            complement(57086..58117)
                     /locus_tag="VVR18_000062"
     CDS             complement(57086..58117)
                     /locus_tag="VVR18_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
                     /protein_id="HEU6031671.1"
                     /translation="MVSTIGIVSLSSGIIGEDFVKHEVDLGIQRLKDLGLNPIFLSHS
                     LKGLDFIKDHPEARAEDLIHAFSDDSIDMILCAIGGDDTYRLLPYLFENDQLQKVIKQ
                     KIFLGFSDTTMNHLMLHKLGIKTFYGQSFLADICELDKEMLAYSLHYFKELIKTGRIS
                     EIRPSDVWYEERTDFSPTALGTPRVSHTNTGFDLLQGSAQFEGKILGGCLESLYDIFD
                     NSRYADSTELCQKYKLFPDLSDWEGKILLLETSEEKPKPEDFKKMLLTLKDTGIFAVI
                     NGLLVGKPMDETFHDDYKEALLDIIDSNIPIVYNLNVGHATPRAIVPFGVHAHVDAQE
                     QVIRFDYNK"
     gene            complement(58372..59055)
                     /locus_tag="VVR18_000063"
     CDS             complement(58372..59055)
                     /locus_tag="VVR18_000063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1129 domain-containing protein"
                     /protein_id="HEU6031672.1"
                     /translation="MSQIDLQKLTKKNQEFVHIATQQFIKDGKTDAEIQTIFEEVIPQ
                     ILEEQSKGTTARSLYGAPTHWAHSFTVKEQYEKEHPKENDDPKLMIMDSALFITSLFA
                     LVSALTTFFAADQAFGYGLITLLLVGLVGGFAFYLMYYFVYQYYGSDMDRSQRPPFWK
                     SVLVILASMFLWLLVFFATSFLPASLNPVLDPLPLAIIGAALLALRFYLKKRLNIRSA
                     SAGPTRYQE"
     gene            complement(59067..60011)
                     /locus_tag="VVR18_000064"
     CDS             complement(59067..60011)
                     /locus_tag="VVR18_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEU6031673.1"
                     /translation="MKQVFLSTTTEFKEIDTLEPGTWINLVNPTQNESLEIANTFDID
                     IADLRAPLDAEEMSRITIEDEYTLIIVDVPVTEERNNRTYYVTIPLGIIITEETIITT
                     CLEPLPVLDVFINRRLRNFYTFMRSRFIFQILYRNAELYLTALRSIDRKSEQIESQLH
                     QSTRNEELIELMELEKTIVYFKASLKTNERVIKKLTSSTSNIKKYLEDEDLLEDTLIE
                     TQQAIEMADIYGNVLHSMTETFASIISNNQNNIMKTLALVTIVMSIPTMVFSAYGMNF
                     KDNEIPLNGEPNAFWLIVFIAFAMSVSLTLYLIHKKWF"
     gene            60143..62974
                     /gene="uvrA"
                     /locus_tag="VVR18_000065"
     CDS             60143..62974
                     /gene="uvrA"
                     /locus_tag="VVR18_000065"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HEU6031674.1"
                     /translation="MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFD
                     TLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTT
                     TEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK
                     GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRL
                     FDSIEAALRIAEGYVIIDTMDDSELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCS
                     ECDGLGIKLEVDTDLVVPDASKTLHEGALAPWNPISSNYYPNMLEQAMKVFGVAMDKP
                     FEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYT
                     RTQMRLYMNELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTL
                     SENEAIIARPILKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLS
                     GVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLIDVGPGA
                     GVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVTGARENNL
                     QNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHV
                     DRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRC
                     EACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVE
                     FFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYIL
                     DEPTTGLHTEDIARLLKVLARFVDAGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGT
                     IIVTGTPEEVAANEASYTGHYLKGKLHHE"
     gene            62967..64028
                     /locus_tag="VVR18_000066"
     CDS             62967..64028
                     /locus_tag="VVR18_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEU6031675.1"
                     /translation="MNKRVQAFLAKMQEKELDGIIINNLKNVYYLTGFWGSNGTVFIS
                     RDRQVLVTDSRYIIAAKQETSGFEIVADRDELAVIAGIVKDMNLTRIGFEDEISVSYY
                     HRMQAAFAGLNLLPQTQFVEGLRMIKDEAEIAAIRKACSISDQAFRDALDFIKPGKTE
                     IEIANFLDFRMRELGASGLSFDTILASGINSSKPHAHPMHKPVELGEAITMDFGCLYD
                     HYVSDMTRTIYLGHVSDEQAEIYNTVLKANQALIDQAKAGLGFRDFDKIPRDIIIEAG
                     YGDYFTHGIGHGIGLDIHEEPYFSQTSTETIKTGMALTDEPGIYIEGKYGVRIEDDIL
                     ITETGCELLTLAPKELIVI"
     gene            64160..64558
                     /gene="spx"
                     /locus_tag="VVR18_000067"
     CDS             64160..64558
                     /gene="spx"
                     /locus_tag="VVR18_000067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Spx"
                     /protein_id="HEU6031676.1"
                     /translation="MIKIYTVSSCTSCKKAKTWLNAHQLSYKEQNLGKEGITREELLD
                     ILTKTDNGIASIVSSKNRYAKALGVDIEDLSVNEVLNLIMETPRILKSPILVDEKRLQ
                     VGYKEDDIRAFLPRSVRNVENAEARLRAAL"
     gene            64624..65193
                     /locus_tag="VVR18_000068"
     CDS             64624..65193
                     /locus_tag="VVR18_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEU6031677.1"
                     /translation="MKKIVLVSLAFLFVLVGCGQKKETGPATKTEKDTLQSALPVIEN
                     AEKNTVVTKTLVLPKSDDGSQQTQTITYKDKTFLSLAIQQKRPVSDELKTYIDQHGVE
                     ETQKALLEAEEKDKSIIEARKLAGFKLETKLLSATELQTTTSFDFQVLDVKKASQLEH
                     LKNIGLENLLKNEPSKYISDRLANGATEQ"
     gene            65280..65546
                     /locus_tag="VVR18_000069"
     CDS             65280..65546
                     /locus_tag="VVR18_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HEU6031678.1"
                     /translation="MGFTEETVRFKLDDSNKKEISETLTDVYASLNDKGYNPINQIVG
                     YVLSGDPAYVPRYNNARNQIRKYERDEIVEELVRYYLKGQGVDL"
     gene            65550..65969
                     /gene="ruvX"
                     /locus_tag="VVR18_000070"
     CDS             65550..65969
                     /gene="ruvX"
                     /locus_tag="VVR18_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002939356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HEU6031679.1"
                     /translation="MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIQINEEQGQFGFDR
                     VKELVDTYKVERFVVGLPKNMNNTSGPRVEASQAYGAKLEEFFGLPVDYQDERLTTVA
                     AERMLIEQADISRNKRKKVIDKLAAQLILQNYLDRKF"
     gene            65985..66290
                     /locus_tag="VVR18_000071"
     CDS             65985..66290
                     /locus_tag="VVR18_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HEU6031680.1"
                     /translation="MSHDHNHDHEERELITLVDEQGNETLFEILLTIDGKEEFGKNYV
                     LLVPVNAEEDEDGQVEIQAYSFIENEDGTEGELQPIPEDSEDEWNMIEEVFNSFMEE"
     gene            66498..67748
                     /locus_tag="VVR18_000072"
     CDS             66498..67748
                     /locus_tag="VVR18_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000464354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEU6031681.1"
                     /translation="MFEVEEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTG
                     TNGKGSTIAFMRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLTDQVKE
                     MEKTLLQTPAQLSFFELLTLVAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVIT
                     SIGLDHQETLGDSLEAIAEQKAGIFKAGKKAVIAKLPPEARLVCQKKAESLAVNLYQA
                     GQDFLMLNGDFSSSLLNLSQLNIGLEGVYQQENAALALQTFLLFMGEGKEAVDEQAVR
                     KALEQTHWAGRLERIRPQIYLDGAHNLPALTRLVEFIKEKEQEGYRPQILFGSLKRKD
                     YQGMLGYLTENLPQVELKMTGFDYQGSLDETDVTGYHVIPSYREFISSFEERADAQDL
                     LFVTGSLYFISEVRGYLLDREQIN"
     gene            67745..68290
                     /locus_tag="VVR18_000073"
     CDS             67745..68290
                     /locus_tag="VVR18_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipocalin/fatty acid-binding family protein"
                     /protein_id="HEU6031682.1"
                     /translation="MTPFFELVILGELLVRENFSKLVAERKFIMKLKRFTLSLASLAS
                     FSLLVACSQRAQQVQQPVAQQQVQQPAQQNTNTANAGGNQNQAAPVQNQPVAQPTDID
                     GTYTGQDDGDRITLVVTGTTGTWTELESDGDQKVKQVTLDSANQRMIIGDDVKIYTVN
                     GNQIVVDDMDRDPSDQIVLTK"
     gene            68436..69968
                     /gene="cls"
                     /locus_tag="VVR18_000074"
     CDS             68436..69968
                     /gene="cls"
                     /locus_tag="VVR18_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000877342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HEU6031683.1"
                     /translation="MKYRKFQLLMSKYGFSLSIMLLELCLVFGLFLYLGRMAPILWIT
                     VLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKK
                     LGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWK
                     KMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTG
                     DYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHV
                     ERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPY
                     GSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRII
                     TPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYR
                     SLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAP
                     IL"
     gene            70226..71764
                     /locus_tag="VVR18_000075"
     CDS             70226..71764
                     /locus_tag="VVR18_000075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HEU6031684.1"
                     /translation="MSVYGRVEEVHKENREPLEYQIEQESHHRESSRLPLVKILLWST
                     LVTGITLGVPLLLDLMSAQEVQDFYAGWALHQTGKIYSDYYGSQGLLYYLLTYVSQGG
                     FFFAIFEWLALVAGGFFLFRSADTLTEQGDQAGHLVTIFYMLVTGLAFGGGYATLLAL
                     PFLFAAFSLVAAYLSNPSHDKGFVRIGLALAGGFFFAPLSSLLFIAVVSLGLLVFNLG
                     HRRFAHGFYQFLAVALGFSLVFYPTAYYSAATGSFGDAISGIRYPIDSIRFDFTSKIL
                     ENMFFYGLLSLGLGFVVCIFLGLFQSKPFKLYVISVPASLVVILGLILLFFSQEPLHA
                     SYLMVVFPVFLLLLVTNIKSQQRGRSARRSRRETPVSLWSRFFKGNLYLLVFGFVYLL
                     SVPFLMKFVLYPVPYQERNRLADLVKEETNTEDAIYAWDDTATLYRKSERLSPSAILS
                     PLHYTATEENRNKLLNDLKEKQPKVIVVNDKVVVWSEVETLLKENYQQVKTDYSEFKV
                     YKIK"
     gene            71884..74091
                     /gene="nrdD"
                     /locus_tag="VVR18_000076"
     CDS             71884..74091
                     /gene="nrdD"
                     /locus_tag="VVR18_000076"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004239081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase"
                     /protein_id="HEU6031685.1"
                     /translation="MIALEEKITILPTLFVEKRDGRRVVFDVDKIDKALHKAADKVMD
                     VTPLVEKRLNDLTERIITEIHSRFPQGIKIYEIQNIVEHELLEAKEYALAEEYITYRT
                     QRDFERSKATDINFSIHKLLNKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLQML
                     PKHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLENGFKIGNAEVESPKSIQTA
                     TAQISQIIANVASSQYGGCSADRIDEILAPYAEKNYQKHLKDAEEWVLPEKREDYAWK
                     KTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSRFEREIQKAILNIRIKGLG
                     SEHRTAIFPKLIFTLKRGLNLEEGTPNYDIKQLALECATKRMYPDVLSYDKIVDLTGS
                     FKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESEGDMNKFWEIFNERM
                     NIAEDALVYRVERTKEATPANAPILYQYGAFGHRLGKEESVDQLFKNRRATVSLGYIG
                     LYEVATVFFGNSWESNPDAKEFTLDIIHDMKRRVEEWSDQYGYHFSIYSTPSESLTDR
                     FCRLDIDKFGSIPDITDKEYYTNSFHYDVRKNPTPFEKLDFEKVYPEAGASGGFIHYC
                     EYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDRCYKCDFEGDFEPTERGFACPNCGN
                     SDPKTVDVVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIKIAGHQVTN"
     gene            74103..74243
                     /locus_tag="VVR18_000077"
     CDS             74103..74243
                     /locus_tag="VVR18_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031686.1"
                     /translation="MGKYQLDDKGRAQVTRYHEKHSKGGAGKKERLLSFREQFLNKNK
                     KK"
     gene            74287..74793
                     /locus_tag="VVR18_000078"
     CDS             74287..74793
                     /locus_tag="VVR18_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000423399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6031687.1"
                     /translation="MELRRPRLADKKAVLDMMTEFEKSQSAHDGGFWDVEDFSYEEWL
                     EGNRNKEMGIWLPENRVPSIQFVLFGESGCALGFLNLRLRLNEGLLNYAGHIGYSIRP
                     SERGKGYAKETLRQGLQVAKEKNIKKALVTCSVNNPASRAVILANGGIFEDARNGVER
                     YWIEVANE"
     gene            74786..75376
                     /gene="nrdG"
                     /locus_tag="VVR18_000079"
     CDS             74786..75376
                     /gene="nrdG"
                     /locus_tag="VVR18_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001064213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HEU6031688.1"
                     /translation="MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVAGCMF
                     HCEGCYNVATWSFNAGIPYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVK
                     RIRKELPDKDIWSWTGYTWEEMMLETPDKLELLSLIDILVDGRYDRTKRNLMLQFRGS
                     SNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE"
     gene            75373..75990
                     /locus_tag="VVR18_000080"
     CDS             75373..75990
                     /locus_tag="VVR18_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribulokinase"
                     /protein_id="HEU6031689.1"
                     /translation="MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALD
                     STTVNLLETDPYITSGRHLVVPKDAPNQKVTASLPVAHELESLQRDILALQAGMDVLT
                     IEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRLARDTTVR
                     NRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT"
     gene            76266..76574
                     /gene="rpsJ"
                     /locus_tag="VVR18_000081"
     CDS             76266..76574
                     /gene="rpsJ"
                     /locus_tag="VVR18_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HEU6031690.1"
                     /translation="MANKKIRIRLKAYEHRTLDTAAAKIVESATRTGAQVAGPIPLPT
                     ERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL
                     "
     gene            76791..77417
                     /gene="rplC"
                     /locus_tag="VVR18_000082"
     CDS             76791..77417
                     /gene="rplC"
                     /locus_tag="VVR18_000082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HEU6031691.1"
                     /translation="MTKGILGKKVGMTQIFTEAGELIPVTVIEATPNVVLQVKTVETD
                     GYNAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNVEGLEVGAEITVETFAA
                     GDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAG
                     RMGGDRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK"
     gene            77442..78065
                     /gene="rplD"
                     /locus_tag="VVR18_000083"
     CDS             77442..78065
                     /gene="rplD"
                     /locus_tag="VVR18_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HEU6031692.1"
                     /translation="MANVTLFDQTGKEAGQVVLSDAVFGIEPNESVVFDVIISQRASL
                     RQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLP
                     QKVRRLALKSVYSEKVAENKFVAVDALSFTAPKTAEFAKVLAALSIDSKVLVILEEGN
                     EFAALSARNLPNVKVATATTASVLDIANSDKLLVTQAAISKIEEVLA"
     gene            78065..78361
                     /locus_tag="VVR18_000084"
     CDS             78065..78361
                     /locus_tag="VVR18_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HEU6031693.1"
                     /translation="MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEA
                     AFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE"
     gene            78379..79212
                     /gene="rplB"
                     /locus_tag="VVR18_000085"
     CDS             78379..79212
                     /gene="rplB"
                     /locus_tag="VVR18_000085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019790357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HEU6031694.1"
                     /translation="MGIRVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRN
                     NNGRITVRHQGGGHKRFYRLVDFKRNKDNVEAVVKTIEYDPNRSANIALVHYTDGVKA
                     YIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTLIHNIELKPGRGGELVRAAGA
                     SAQVLGSEGKYVLVRLQSGEVRMILGTCRATVGVVGNEQHGLVNLGKAGRSRWKGIRP
                     TVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNE
                     K"
     gene            79316..79597
                     /gene="rpsS"
                     /locus_tag="VVR18_000086"
     CDS             79316..79597
                     /gene="rpsS"
                     /locus_tag="VVR18_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000533767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HEU6031695.1"
                     /translation="MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSF
                     IGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRRK"
     gene            79609..79953
                     /gene="rplV"
                     /locus_tag="VVR18_000087"
     CDS             79609..79953
                     /gene="rplV"
                     /locus_tag="VVR18_000087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HEU6031696.1"
                     /translation="MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTP
                     NKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINK
                     RTAHITVAVAEK"
     gene            79966..80619
                     /gene="rpsC"
                     /locus_tag="VVR18_000088"
     CDS             79966..80619
                     /gene="rpsC"
                     /locus_tag="VVR18_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HEU6031697.1"
                     /translation="MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQK
                     ELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINI
                     IEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGAD
                     IARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK"
     gene            80623..81036
                     /gene="rplP"
                     /locus_tag="VVR18_000089"
     CDS             80623..81036
                     /gene="rplP"
                     /locus_tag="VVR18_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003029477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HEU6031698.1"
                     /translation="MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEYGLQATTSHWITN
                     RQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKV
                     MFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE"
     gene            81046..81252
                     /locus_tag="VVR18_000090"
     CDS             81046..81252
                     /locus_tag="VVR18_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HEU6031699.1"
                     /translation="MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAATGQL
                     EQTARLKEVKKQIARIKTVQSEAK"
     gene            81277..81537
                     /gene="rpsQ"
                     /locus_tag="VVR18_000091"
     CDS             81277..81537
                     /gene="rpsQ"
                     /locus_tag="VVR18_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HEU6031700.1"
                     /translation="MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKK
                     YKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII"
     gene            81563..81931
                     /gene="rplN"
                     /locus_tag="VVR18_000092"
     CDS             81563..81931
                     /gene="rplN"
                     /locus_tag="VVR18_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012727667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HEU6031701.1"
                     /translation="MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVK
                     QATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPV
                     ARELREGGFMKIVSLAPEVL"
     gene            82009..82314
                     /gene="rplX"
                     /locus_tag="VVR18_000093"
     CDS             82009..82314
                     /gene="rplX"
                     /locus_tag="VVR18_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HEU6031702.1"
                     /translation="MFVKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKH
                     QRPTNELPQGGIIEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD"
     gene            82338..82880
                     /gene="rplE"
                     /locus_tag="VVR18_000094"
     CDS             82338..82880
                     /gene="rplE"
                     /locus_tag="VVR18_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HEU6031703.1"
                     /translation="MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEA
                     VSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLD
                     KLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTT
                     ANTDEESRALLTGLGMPFAK"
     gene            82898..83167
                     /gene="rpsN"
                     /locus_tag="VVR18_000095"
     CDS             82898..83167
                     /gene="rpsN"
                     /locus_tag="VVR18_000095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S14"
                     /protein_id="HEU6031704.1"
                     /translation="MAKKSMVAREAKRQKIVDRYAEKRAALKAAGDYEGLSKLPRNAS
                     PTRLHNRCRVTGRPHSVYRKFGLSRIAFRELAHKGQIPGVTKASW"
     gene            83452..83850
                     /gene="rpsH"
                     /locus_tag="VVR18_000096"
     CDS             83452..83850
                     /gene="rpsH"
                     /locus_tag="VVR18_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009754342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HEU6031705.1"
                     /translation="MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREG
                     FVKNVEIIEDDKQGVIRVFLKYGPNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLG
                     IAILSTSEGLLTDKEARQKNVGGEVIAYVW"
     gene            84042..84578
                     /gene="rplF"
                     /locus_tag="VVR18_000097"
     CDS             84042..84578
                     /gene="rplF"
                     /locus_tag="VVR18_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HEU6031706.1"
                     /translation="MSRIGNKVIVLPAGVELANNDNVVTVKGPKGELTREFSKDIEIR
                     VEGTEVTLHRPNDSKEMKTIHGTTRALLNNMVVGVSEGFKKELEMRGVGYRAQLQGSK
                     LVLAVGKSHPDEVEAPEGITFELPNPTTIVVSGISKEVVGQTAAYVRSLRSPEPYKGK
                     GIRYIGEFVRRKEGKTGK"
     gene            84662..85018
                     /gene="rplR"
                     /locus_tag="VVR18_000098"
     CDS             84662..85018
                     /gene="rplR"
                     /locus_tag="VVR18_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HEU6031707.1"
                     /translation="MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQV
                     IDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHG
                     RVKALADAARENGLKF"
     gene            85036..85530
                     /gene="rpsE"
                     /locus_tag="VVR18_000099"
     CDS             85036..85530
                     /gene="rpsE"
                     /locus_tag="VVR18_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HEU6031708.1"
                     /translation="MAFKDNAVELEERVVAVNRVTKVVKGGRRLRFAALVVVGDHNGR
                     VGFGTGKAQEVPEAIRKAVDDAKKNLIEVPMVGTTIPHEVLSEFGGAKVLLKPAVEGS
                     GVAAGGAVRAVVELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEIAALRGISV
                     SDLA"
     gene            85502..85726
                     /gene="rpmD"
                     /locus_tag="VVR18_000100"
     CDS             85502..85726
                     /gene="rpmD"
                     /locus_tag="VVR18_000100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012386624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HEU6031709.1"
                     /translation="MVFQFLIWHKKGDKMAQIKITLTKSPIGRIPSQRKTVVALGLGK
                     LNSSVIKEDNAAIRGMITAVSHLVTVEEVN"
     gene            85871..86311
                     /gene="rplO"
                     /locus_tag="VVR18_000101"
     CDS             85871..86311
                     /gene="rplO"
                     /locus_tag="VVR18_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HEU6031710.1"
                     /translation="MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGG
                     GVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIV
                     KAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI"
     gene            86324..87634
                     /gene="secY"
                     /locus_tag="VVR18_000102"
     CDS             86324..87634
                     /gene="secY"
                     /locus_tag="VVR18_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HEU6031711.1"
                     /translation="MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANS
                     LNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASIVVQLLQMDILPKFVEWGKQ
                     GEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTA
                     GSMIVTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSII
                     FVIILIITVLLIIYFTTYVQQAEYKIPIQYTKVAQGAPSSSYLPLKVNPAGVIPVIFA
                     SSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTFVQI
                     NPEKAAESLQKSGAYIHGVRPGKGTEEYMSKLLRRLATVGSLFLGVISILPIAAKDVF
                     GLSDVVAFGGTSLLIIISTGIEGIKQLEGYLLKRKYVGFMDRTE"
     gene            87785..88423
                     /locus_tag="VVR18_000103"
     CDS             87785..88423
                     /locus_tag="VVR18_000103"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HEU6031712.1"
                     /translation="MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMVNQTE
                     MGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLA
                     ELGIELEGVINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
                     PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK"
     gene            88540..88758
                     /gene="infA"
                     /locus_tag="VVR18_000104"
     CDS             88540..88758
                     /gene="infA"
                     /locus_tag="VVR18_000104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HEU6031713.1"
                     /translation="MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNY
                     IRILAGDRVTVEMSPYDLTRGRITYRFK"
     gene            88783..88899
                     /gene="rpmJ"
                     /locus_tag="VVR18_000105"
     CDS             88783..88899
                     /gene="rpmJ"
                     /locus_tag="VVR18_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013773089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HEU6031714.1"
                     /translation="MKVRPSVKPICEYCKVIRRNGRVMVICPANPKHKQRQG"
     gene            88917..89282
                     /gene="rpsM"
                     /locus_tag="VVR18_000106"
     CDS             88917..89282
                     /gene="rpsM"
                     /locus_tag="VVR18_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HEU6031715.1"
                     /translation="MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVR
                     VRDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNT
                     KNNARTRKGKAVAIAGKKK"
     gene            89300..89683
                     /gene="rpsK"
                     /locus_tag="VVR18_000107"
     CDS             89300..89683
                     /gene="rpsK"
                     /locus_tag="VVR18_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HEU6031716.1"
                     /translation="MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSS
                     AGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAG
                     LEVTAIRDVTPVPHNGARPPKRRRV"
     gene            89726..90661
                     /locus_tag="VVR18_000108"
     CDS             89726..90661
                     /locus_tag="VVR18_000108"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HEU6031717.1"
                     /translation="MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLA
                     SLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGP
                     AEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVG
                     TLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEH
                     LDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLT
                     EKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK"
     gene            90673..91059
                     /gene="rplQ"
                     /locus_tag="VVR18_000109"
     CDS             90673..91059
                     /gene="rplQ"
                     /locus_tag="VVR18_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HEU6031718.1"
                     /translation="MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTV
                     EKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAER
                     NGGYTRILKTEPRRGDAAPMAIIELV"
     gene            91324..91590
                     /locus_tag="VVR18_000110"
     CDS             91324..91590
                     /locus_tag="VVR18_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002905356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HEU6031719.1"
                     /translation="MKAIITVVGKDKSGIVAGVSGKIAELGLNIDDISQTVLDEYFTM
                     MAVVSSDEKQDFTYLRNEFEAFGQTLNVKINIQSAAIFEAMYNI"
     gene            91600..92937
                     /locus_tag="VVR18_000111"
     CDS             91600..92937
                     /locus_tag="VVR18_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HEU6031720.1"
                     /translation="MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPDINRAAEKI
                     YQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIGAATDATDYVVLAKALDKA
                     AKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALTETDKVCSSVNIGSTKSGINMTA
                     VADMGRIIKETANLSDMGAAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGV
                     VKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPA
                     VGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDE
                     GMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKT
                     TAVRIIPKGREGDMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKN"
     gene            93181..93873
                     /locus_tag="VVR18_000112"
     CDS             93181..93873
                     /locus_tag="VVR18_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEU6031721.1"
                     /translation="MVKVRLYLVRHGKTMFNTIGRAQGWSDTPLTAEGERGIQELGTG
                     LRESDLQFERAYSSDSGRTIQTMGIILEELGLQGKIPYRMDKRIREWCFGSFDGAYDG
                     DLFMGIIPRIFNVDHVHQLSYAELAEGLVEVDTAGWAEGWEKLSGRIKEGFEMIAKEM
                     EDQGGGNALVVSHGMTIGTIVYLINGMHPHGLDNGSVTILEYEDGQFRVEVVGDRSYR
                     ELGREKMEEGSI"
     gene            complement(93976..95611)
                     /locus_tag="VVR18_000113"
                     /pseudo
     CDS             complement(93976..95611)
                     /locus_tag="VVR18_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520796.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
     gene            complement(95601..96692)
                     /locus_tag="VVR18_000114"
                     /pseudo
     CDS             complement(95601..96692)
                     /locus_tag="VVR18_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001289361.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
     gene            complement(96705..97073)
                     /locus_tag="VVR18_000115"
     CDS             complement(96705..97073)
                     /locus_tag="VVR18_000115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU6031722.1"
                     /translation="MAVGLSYEDPAVKLLNDGANIKVVYPKEGTVFLPASAAIVKKAK
                     NMENAKKFIDFIISQEVQDTLGTTTTNRPVRKNAKTSENMKPIDKIKTLTEDYDYVIK
                     NKSDIVKKYNEVFTDIQSKQ"
BASE COUNT        29163 a        18204 c        21734 g        28030 t
ORIGIN      
        1 ttttttttcg tatttcataa acatttcata tttgggtttt ataatagtct tacaaatatg
       61 gaggtgacaa atgaatccaa tccaaagatc ttgggcttat gtcagcagaa agcgactgag
      121 aagttttatt ttatttctga ttttattggt cttattggcc ggaatttcag cctgtttgac
      181 tctgatgaag tccaacaaaa cagtagaaag caatctttat aaatcactca atacatcttt
      241 ttctattaag aagatagaga atggtcagac attcaagttg tcagacctag catctgtaag
      301 caagattaag gggctggaaa atgtctctcc tgaacttgag acggtcgcaa aactaaaaga
      361 caaggaagca gtgactggcg agcagagcgt ggagcgtgat gatttatcag ctgcagacaa
      421 taacttggtt agcttaacgg ctcttgagga ttcatccaag gatgtaacct ttaccagttc
      481 ggctttcaat ctaaaagaag ggcgacacct tcaaaaaggg gattccaaga aaatccttat
      541 ccacgaagaa ttggctaaga agaacggtct ttcacttcat gacaagattg gcttggatgc
      601 tggtcagtct gaatctggaa aaggacaaac agtagagttt gagattattg gcatcttttc
      661 tggtaaaaaa caagagaaat tcacaggctt gtcttctgac ttcagtgaaa atcaagtctt
      721 tacagactat gaaagtagcc aaaccctttt gggcaatagt gaagctcaag tcagtgcagc
      781 acgcttctat gtagaaaatc ctaaggaaat ggacggactc atgaagcagg tagaaaactt
      841 ggccttggaa aatcaaggct accaagtcga aaaggaaaac aaggcttttg aacaaatcaa
      901 agactcagtt gcaactttcc aaaccttcct gaccatcttc ctttatggga tgttgatagc
      961 aggagctgga gccttaattc tggttttgtc tctctggttg agagaacggg tctatgaagt
     1021 ggggatttta cttgcacttg gaaaaggcaa gagctcgatc ttcctacaat tctgtttaga
     1081 ggtagttttg gtatctcttg gagctttgct tccagcattt gttgcaggaa acggaatcac
     1141 aacttaccta ctccaaactc tactagcaag tggagatcag gcaagcttac aagatacact
     1201 agccaaagca agcagtttat caactagtat cttatctttt gcagaatcct atgtttttct
     1261 agttctgctt agttgcttat ctgtagccct ttgtttccta ttcttattta gaaaatcacc
     1321 gaaagaaatt ttatcatcta ttagttaaga aggagaaatc atgactttat tacaattaca
     1381 agatgttacc taccgttata agaatactgc tgaagcagtc ctatatcaga tcgattataa
     1441 ttttgaaccc ggaaaatttt acagtattat tggggagtca ggagcaggaa aatccacact
     1501 cttgtcccta cttgctggtc tagatagtcc tgttgaaggt tctatccttt ttcaaggaga
     1561 ggatattcgt aagaagggct attcttacca tcgcatgcac catatttccc tggtctttca
     1621 aaattataac ttgatagatt atctttctcc gctggaaaat atccaattgg tcaacaaaaa
     1681 ggcaagcaag gatacacttc ttgagcttgg tttggatgaa agtcagatca agcggaatgt
     1741 tctccagtta tcaggtggtc aacagcaacg tgttgccatt gctcgcagtt tggtctcaga
     1801 agctccagtt attctagctg atgagccaac aggaaatctg gatcctaaaa ctgctggaga
     1861 tattgtcgaa ctactcaaat cacttgccca gaaaacaggt aaatgtgtga ttgtcgtaac
     1921 tcacagtaaa gaagtggcac aagcgtcaga tattacactt gaattaaagg ataagaaact
     1981 gactgaaacg cgcaatacta gtaaataatt tgagcttatt ttaatagaat gattaaaaca
     2041 aaatctagaa agggaatcta tgttacacaa cgcatttgcc tatgttacaa ggaagttttt
     2101 caaatcgatt gtcatcttcc tgattattct cctcatggcg agcttgagtt tggtcggctt
     2161 gtcaatcaag ggagctactg ccaaggcttc tcaggagacc tttaaaaata tcaccaatag
     2221 cttctccatg caaatcaatc gtcgcgtcaa ccaaggaacg cctcgtggtg ctgggaatat
     2281 caagggtgaa gacatcaaaa aaatcaccga aaacaaggcc attgagtctt atgtcaaacg
     2341 tatcaacgct atcggagatt tgactggata tgacctgatt gaaacgccag aaaccaagaa
     2401 gaatctcact gctgatcgtg ccaagcgttt tggaagtagc ttgatgatta caggtgtcaa
     2461 tgactcctct aaagaagaca agtttgtctc tggttcttat aaactagtcg aaggagagca
     2521 cttaaccaac gacgacaagg ataaaatcct cttgcacaag gacttggcag ccaaacacgg
     2581 ctggaaagta ggggacaagg ttaaactgga ctctaatatc tacgatgcag ataatgaaaa
     2641 aggagccaag gaaacagttg aagtgacaat caagggactc tttgatggtc ataataagtc
     2701 agcagtaacc tactcacaag aactttacga aaacacagct attacagaca ttcacactgc
     2761 tgcaaaactt tatggataca cagaagacac agccatttat ggggacgcaa ccttctttgt
     2821 aacagcagac aagaacttgg atgatgttat gaaagagttg aatggcatca gtggtatcaa
     2881 ctggaagagc tacacactcg tcaagagctc ctctaactac ccagctcttg agcaatctat
     2941 ctctggtatg tacaagatgg ccaacctcct cttctggggt agcttgagct tctcagttct
     3001 cctccttgcc ctcttgctca gcctttggat caacgcccgt cgcaaggaag tgggaattct
     3061 cctctctatc ggcctcaagc aggcaagtat cttgggtcaa ttcatcaccg aatctatctt
     3121 gattgctatc cctgctctag tttctgctta cttcctagct aattacactg cccgtgcaat
     3181 tggaaacact gtccttgcca atgtgacttc aggtgttgcc aaacaggcta gtaaggcggc
     3241 tcaagcctct aaccttggtg gtggtgcaga agtagatggc tttagcaaga ccttgtcgag
     3301 cctagacatt tccattcaga catcagactt tatcatcatt tttgtccttg ccttggttct
     3361 agtggttctc gttatggcgc ttgcttcaag caatctcctt agaaaacaac caaaagagct
     3421 cttgctggat ggtgaataaa tttgaaaaaa tgagtctgga ataaagattg catcttgtgt
     3481 ttctattcaa gaatagtgga taggaatggc tatttaacaa ttcaaaataa atccgaaagc
     3541 agtggtgaaa atcattgctt tcagttgctt tctttgtact ttagtgctta aatataatat
     3601 actaaagtta tggaatttat gagaaaggat ttcacaacgt tttatctagt ggtcagttgc
     3661 ttacagacaa aaggccagca agagactata atagaaaata gagtaggtat ttattctaag
     3721 aaaaataaaa aatagagagc agttaaagta tgaaaatttt aattgtagaa gatgaagaga
     3781 tgatccgtga gggggtcagt gattatttga cggattgtgg ctatgaaact attgaggcag
     3841 cggacggtca ggaagctctg gagcaatttt ctagctatga ggtggccctg gttttactgg
     3901 atatccagat gcccaagctc aacggcttag aagtcctagc tgagattcgt aaaaccagtc
     3961 aggttcctgt cttgatgttg acagcttttc aggatgagga atacaagatg agtgcctttg
     4021 cctctttggc agatggctat ctggaaaaac ctttctccct ctccctttta aaagtgaggg
     4081 tggacgcgat tttcaagcgc tactacgata caggacgaat cttttcttac aaggatacca
     4141 aggtggactt tgaaagctac agtgcaagcc tcgcaggtca agaagtgcct atcaatgcca
     4201 aagagttgga aattctggac tatctagtga aaaatgaagg ccgggccttg actcggtctc
     4261 agattatcga tgccgtctgg aaagcgacag atgaggttcc ctttgaccgt gttattgatg
     4321 tttatatcaa ggaattgcgg aaaaagctag acttggattg tatcctcact gtgcgcaatg
     4381 ttggttataa attggagcga aaatgaaacg aacaggttta tttacaaaga tatttatata
     4441 taccttctcg atatttagtg ttctggttat ctgccttcat ttagctattt attttctttt
     4501 tccttcgact tatctgagtc atcgtcagga aaccattggt caaaaggcaa cagccattgc
     4561 ccagtcccta gaagggaaag ataggcagag tatcgagcaa gtgttagact tgtattccca
     4621 gactagtgat atcaagggga ccgtcaaagg tgagatgacc gaggataagt tagaagtcaa
     4681 ggacagtctt cctctggaca cagaccgcca gacaacctct ctctttattg aggagcgcga
     4741 ggtgaaaacg caagacggtg gtactatgat tctccagttt ctagcttcca tggatttaca
     4801 aaaggaagca gagcaaatca gtctccagtt tcttccctat accttgctgg cctcctttct
     4861 gatttccctc ttggtggcct acatctacgc tcggactatt gttgcaccga ttttggaaat
     4921 caagcgggtg acccgtcgga tgatggacct ggattcccaa gtgcgattgc gcgtggattc
     4981 taaggatgag ataggtaatc tcaaggaaca aatcaatagc ctctaccagc atctcttgac
     5041 tgttattgcg gacttgcatg aaaagaatga agccattctc cagctggaga agatgaaggt
     5101 cgaattccta cgaggagctt ctcatgaatt gaaaacaccg ctggctagtt tgaaaatcct
     5161 aatcgaaaat atgagagaga atatcggtcg ttataaggat agagaccagt atctgggagt
     5221 tgccttgggg attgtggatg aactcaatca ccatgttctg cagatacttt ccctctcttc
     5281 tgtgcaggaa ttgcgagatg atagggaaac aattgacctc ctccagatga cgcaaaatct
     5341 ggtcaaagat tatgccttgc tagccaagga aagagagctc cagatagaca atagtttgac
     5401 ccatcagcag gcttatctaa acccatcagt tatgaagttg attctttcta atctcatcag
     5461 caatgccatt aagcactctg ttccaggtgg cttagttcga attggagaaa gagaaggaga
     5521 actttttatc gaaaatagct gtagctcaga ggaacaagaa aaactagccc agtctttttc
     5581 tgacaatgct agtcgcaagg tcaaggggtc tggtatgggg ctctttgtgg ttaagagtct
     5641 attagaacat gaaaaattag cttatcgttt cgagatggag gagaatcgtt taaccttctt
     5701 tatagatttt ccaaaagtcg tccaagacta gggagagaaa gggtttacat agatggagtt
     5761 agaagaaaat caatcgaaac tgcgggaaaa actagatttt tttggcaaaa agtgataaaa
     5821 tgaacaatgt aaatgggatg acccataaaa atatacagga ggcctgataa aatggcaatc
     5881 gtttcagcag aaaaatttgt ccaagcagcc cgtgacaacg gttatgcagt tggtggattt
     5941 aacacaaaca accttgagtg gactcaagct atcttgcgcg cagcagaagc taaaaaagct
     6001 ccagttttga tccaaacttc aatgggtgct gctaaataca tgggtggtta caaagttgct
     6061 cgcaacttga tcgctaacct tgttgaatca atgggtatca ctgtaccagt agctatccac
     6121 cttgaccacg gtcactacga agatgcactt gagtgtatcg aagttggtta tacttcaatc
     6181 atgtttgacg gttcacacct tccagttgaa gaaaacctta aattggctaa agaagttgtt
     6241 gaaaaagcac acgctaaagg tatctcagta gaagctgaag ttggtactat cggtggtgaa
     6301 gaagacggaa tcatcggtaa aggtgaattg gctccaatcg aagacgctaa agcaatggtt
     6361 gaaactggta tcgacttctt ggcagctggt atcggtaaca tccacggccc ttacccagta
     6421 aactgggaag gtcttgacct tgaccacttg caaaaattga cagaagctct tccaggattc
     6481 ccaatcgtat tgcacggtgg atcaggtatt cctgatgagc aaatccaagc agctatcaaa
     6541 cttggtgttg ccaaagttaa cgttaacaca gaatgccaaa tcgcattcgc taacgcaact
     6601 cgtaaatttg ctcgtgacta cgaagcaaac gaagcagaat acgataagaa aaaactcttc
     6661 gacccacgta aattcttggc tgacggtgta aaagctatcc aagcatcggt tgaagaacgt
     6721 atcgacgtat tcggttcaga aggtaaagca taatctagct gaataataca gataaaacct
     6781 gcctgtgagg gtgggttttt tgatttcaag ctactcgttt tagtatagta aactgaatct
     6841 agactagcac aatgctgctt ctatagcgtt ttgaaactag aataggataa cataactgct
     6901 aaaagatttc tataaattca tttgattttc ctaatcaatt tgttcgtatc ctatttcact
     6961 ccactataaa acattcttat caattgattt gaatgccaaa attccatcgt tcctgtctta
     7021 tttcatttgg ctataaaaaa ctctcctggg aaattccagg agagtatgat tacttatttg
     7081 aacttgaatc cttcgtaaat aagctctgtt tttggatttt gtttcttaat ctgtttggca
     7141 agtgccttca tcatagaaat aggaccacac atatagacgg ttgcatgttc gggcacttct
     7201 ttttgttcaa aattaagata gccgtctttc gtactgtcga ttagatggag ttcaaaatta
     7261 ggatttttct gagcatagtt acggagtaaa tctaggtaga ctgcattttc atctccacgg
     7321 aagctatagt agaagtgaac ctgtttatct aaaataggat gttcacggat gtaagagatg
     7381 aagggggtga tcccaatacc tccagcaatc caaacctgat tttctcgtcc ttcttctatg
     7441 atcatgtgtc cgtaagctct gtctagggtt actttgctgc cggcttgaag attatcatag
     7501 atattattgg tatggtcgcc tgaattttta acagtaaagt aaagagtttg accatgacct
     7561 cctgagatag aaaagggatg cggagcactt tcaaagcctt cttggaaaat ctttagaaag
     7621 gcaaattgtc ctgattgata gttgaaaggt ctgcaaagat ggatttgaat ttctctagta
     7681 tcgtgattta agcgtttgag atgggtaatt ttccctagat aggggaagga aatcttttga
     7741 tatagaaaaa tgatataaaa accagctagt aagcctaaaa gggcatagct accaacaaga
     7801 aaacttagaa gattaaatgt aaggagacga ttgcccatta tcatgtagat gtgaaagagt
     7861 cctaaaatat aggctaggta aaccaagcgg tgaatccatc gccaagcttc gtattggatg
     7921 tatttgccta aataggcgac aaggatgatg ctggcaaaga tatagatggc aagattgcca
     7981 aactgagcag ctaagcgaga gccccacaaa ccgcccatac taaagttatg aaagattagt
     8041 aggatgatgg agagaaaggc tgtgaatttg tggacggtgt agaccttctc caaaccgtga
     8101 aaccagcttt ctagtagtgg gagacgagtg gctaggataa aagtcagaga taggcttgtt
     8161 aaagctagtc ctggaatcat gaattgggga gaagtgttca tccaagtcaa aagagtcaag
     8221 ataaaactag ctatgataaa gagtagtcct ttgactgatt tcatagaaaa ttccatttca
     8281 tttagatttc gatttgttgt aaatgaattt gttacatttt atcatagaaa atgtatggtg
     8341 tcaaattgag gtctataaat atctactctc atcaaaaaac tctccaattg aactggagag
     8401 tggctgttta tactcaatga aaatcaaaga gcaaactagg aagctagccg caggctgctc
     8461 aaaacaccgt tttgaggttg tggatagaac tgacgaagtc agtaacatat atacggcaag
     8521 gtgaagctga cgtggtttga agagattttc gaagagtatt attctgcagc ttgttgccaa
     8581 cgtttggcta gcatatgaga caggctagaa attgctaggt taaagctgaa gtagatgagg
     8641 gcaatcagga tgtaaagact gaagacctgc tctggttcga aataacggcc catgagaatt
     8701 tggctggctc caaagagttc ttgtagggcg ataacagagt agaggagact ggtatcctta
     8761 atcacggtaa caaactgaga aatgatggct ggtagcattt tgcggctggc ttgtgggaga
     8821 atgatgtagt agaggatttg ggctgaggtg aagccttgtg acattcctgc tttgtattgt
     8881 cccttgtcta cggcattgag accgcctcga ataatctcag ccaaggctgc tgatgtaaag
     8941 agagtaaagg ctgtaatacc tgctggtgtg gacttcattt tgaacaccaa aaagatagta
     9001 aaaatccaga gaaggttggg aacgttgtgc acaaactcga tataaatact ggaaataatg
     9061 cgtaagatag gattttttcc atttcgcatg acggcaagca cggtaccgat gatagtagag
     9121 aggatgatgg caatcagaga aatatagagg gtcaagccaa atcctttaaa gataaagact
     9181 aggttatctg gggttaaaat ttctaaaata gattccatag taacctccta aagtgaatag
     9241 gcttttttat tggcttgctc catcttgcga ccaaactggg caacagggaa gcatagggca
     9301 aagtagagaa gagcagcacc taaaaaggct gggatatagt ttccgttgag agccgaccaa
     9361 gacttagtca caaacatcaa gtctactcca gagatgatag ctacagtaga tgtgttcttg
     9421 atgaggttaa caatttggtt ggtcaatgga gggagaatga tgcggaaggc ctgaggcaag
     9481 gtaatcaagc gcatggcact gatataggta aaaccttgcg acaaggcggc ctccatctga
     9541 ccactaggaa tagactgaat ccctgaacga ataacctcag cgatataagc gccgtgatag
     9601 agtcccacgc agagaacggc tgtccaataa attggaatca tgatgatatg gtcactgata
     9661 agaggtaggc cataaaaaac aataacaaac tgcaccaaga gaggagtatt ttggtaaaat
     9721 tcaacaaaga tgcgagctaa aatgcgtaaa attggacgtt tactggttga catggcacca
     9781 aagaagattc ctaagaccat ggcgaggata aaggatccaa tcgctagggc aagagtaaag
     9841 aggaaaccat tgaaaaattg ttcaaaatcc tgaaaatagg ctgtccaaga tgataaatct
     9901 gtcatagggt atcctcctta atctgcggta tgactagatg gtttgagctt gtaacggtca
     9961 taaagtttct gcaaactacc atccttgctc catttagtaa ccaagttatc aagatagtcg
    10021 ttgagctctg tatttgattt cttggtaaca ataccgtagt cagatggctt gaaactatca
    10081 tctagtagtg ctgtccgttt attagtgtag ccagatagaa tagagcggtc aacggaaaag
    10141 gcatcgatac gatgagcgtg cagggaagta atcaattctg ggtaggaacc aagttcgaca
    10201 aatttaaagg ttagaccttt ctttttgccc agttcagtaa tcaggcgttg ggtgatggag
    10261 ccttgggcga ctccgatggt tttgccgttt aggtcctcaa tctttttgat tttggcagat
    10321 ttattgacca aaaatccaga agcgtctgtg tagtagggac tggtaaagtt gtagagtttt
    10381 ttgcgttcgt ccgtgatggt aaaggtcgcg atatccatat cgacctgttc attgtctaga
    10441 agggggccgc gggtttgtgc tgtaaccggc acatagcgaa tcttgacctt gagttcatca
    10501 gctaccatct tggccaagtc ggtttcgata ccagaataag taccggtctt gggatctttg
    10561 taaccaaaat tgggaacgtc ttgtttgaca ccgacaacca gttcgcctct tttttgaatg
    10621 tctgcgatac tagtatcagc ctggactggt ttggcagcag caaggccgaa aaggctaatc
    10681 aataatgctg ataaaaagaa ttttttttca taggcgcctc cttatttgac tttgtcactt
    10741 tcgtggttga taattttgct gaggaattgt tgggcacgag gtttgcttgg attgtcaaaa
    10801 aagttatcga catctgtcgt atctactaaa acttctccgt cggccataaa gataatgcgg
    10861 tccgcaacct ctcgagcaaa gcctatttcg tgggtaacga tgatcatgtt catcccatca
    10921 tgcgccagtt tctgcataac tgctagaaca tctccgatag tctcaggatc aagagcagat
    10981 gttggttcat caaagaggag gagttccgga tgcatagcaa gaccacgagc gatggcgatc
    11041 cgctgttttt gtccaccaga tagcatggcg ggataggaat ctttcttgtc ccatatattt
    11101 acaaattcca gatatttttg ggcggttttt tcagcttctt ttttatcaat tcctagaact
    11161 ttaatgggcg aaagtgtcac gttttctaac accgttttgt gtggataaag gttaaaatgt
    11221 tgaaaaacca tgccgacttc cttgcgaaga ggtaccaaat ctttctggct ggcaccagca
    11281 acttggtgcc cattgactag gagacttcct ttgtcaacag cctctaaacc attgatcgta
    11341 cggataagag tggacttccc agagccagaa ggtccaagca ggacaacaac ttgtcctttt
    11401 tcaaaacgga gattgatgtt gcggagtgcg tggtagtctc cgtaatattt ttcgacgttt
    11461 ttaaattcta ctaaagccat gagcgaactc ctttatgtta gattttataa cacgattctg
    11521 caataaaaga atgttcttgt caaatcatat ctgaaaaaat tcactatagt gaaataagaa
    11581 caggaaaaat cgatcgggac agtcaaatcg atttctaaca atattttaga agtagaggtg
    11641 tactattcta gtttcaatat actataaaat gttataaaaa agcaatctgg atagagaaaa
    11701 cgtctaaatc atgttataat gaagcaatag aattcttaga aagagtggat gtctttttga
    11761 taacacctac ttatgaatgg cagtttgccc tgcaggtaga agatgcggat tttacaaaga
    11821 tagccaagaa ggctggactg ggtcctgagg tggctcggtt attgtttgag agagggattc
    11881 aggaccaaga aagtctgaag aagtttttag aaccttcctt ggagtactta catgatgctt
    11941 atctgctcca tgatatggac aaggcagtgg agcggattcg tcaggctatt gaagaagggg
    12001 aaaatattct cgtttatgga gactatgatg cggatggcat gacttcggct tctattgtga
    12061 aggaaagttt ggaacaactt ggtgctgagt gccgagttta cctgccaaat cgttttaccg
    12121 atggctatgg ccctaatgct agtgtttata aatactttat cgagcaagaa ggaatttcct
    12181 tgattgtgac ggtggacaat ggggttgctg gtcatgaggc tattgcattg gctcagtcta
    12241 tgggagtaga tgtcattgtg acagaccatc attccatgcc tgaaaccctg ccagatgctt
    12301 atgctattgt ccatcctgaa catccagatg cggattatcc ttttaaatat ttggctggtt
    12361 gtggagttgc tttcaagttg gcttgtgccc tgttagaaga agtgcaagtg gaattgcttg
    12421 atttggtcgc tattggaact attgcagata tggtgagtct gacggatgaa aatcgtatct
    12481 tagttcaata tggtctggaa atgttgggtc atacccagcg cattggtctg caagaaatgc
    12541 tggacatggc tgggattgct gccaacgaag taacagaaga aacggttggt ttccagattg
    12601 ctcctcgttt gaatgccttg ggtcgcttgg atgatcccaa tcctgccatt gatttgttga
    12661 ctggatttga tgatgaggaa gcgcatgaga ttgcccttat gattcaccag aaaaacgaag
    12721 agcgcaagga aatcgttcag tctatctatg aagaagccaa gaccatggtg gatcctgaga
    12781 agaaggttca ggtcttggcc aaggaaggct ggaatcctgg ggttctagga atcgtgactg
    12841 gtcgtttatt ggaagaattg ggacagacag tcattgttct taatatagaa gacggtcgtg
    12901 ccaagggcag tgctcgtagt gtggaagcgg tcgatatttt tgaagctctg gatccccatc
    12961 gagacctctt catcgccttt ggaggtcatg caggtgcagc gggtatgacg ctggaagttg
    13021 agcaactctc agatttatct caggttttgg aagattatgt tcgtgaaaaa ggtgcagatg
    13081 ctggtggcaa gaataagtta aacctagatg aagagttgga tttggaggca cttagcttgg
    13141 aaacggtcaa aagttttgaa cgtttagctc cttttggaat ggataatcag aaacctattt
    13201 tttatatcaa gaattttcag gtcgaaagtg ctcgtactat gggggcaggt aatgcccatc
    13261 taaagctgaa aatttccaag ggtgaggcga gttttgaagt ggtagccttt ggtcaaggca
    13321 gatgggcgac agagttttct caaaccaaga atctagagtt agcggttaaa ttgtctgtca
    13381 accaatggaa tggccaaact gccctccagt tgatgatggt ggatgcgcga gtggaaggtg
    13441 ttcaactttt taacattcgt ggaaaaaatg cagtcttgcc agaaggtgtt ccagtcttgg
    13501 attttcctgg agaactgcca aatcttgcgg ctagtgaagc tgttgtcgta aaaaacattc
    13561 cagaggatat tactcagctg aagaccattt ttcaggaaca gcatttctct gctgtctatt
    13621 tcaaaaatga tattgacaag gcctattatc tgacaggtta tgggactaga gatcagtttg
    13681 ccaaattgta caagactatt taccagttcc cagagtttga tattcgctac aagctgaaag
    13741 atttggctgc atatcttaat attcaacaaa tcttgctggt caagatgatt caagtatttg
    13801 aagaactagg ctttgtgacg ataaaagatg gtgtgatgac agtcaataaa gaggcgccaa
    13861 agcgggagat aggagaaagt caaatttacc aaaatctcaa acaaaccgtt aaagaccaag
    13921 aaatgatggc gctgggtacg gtgcaagaaa tttatgattt tttgatggaa aaagagtaga
    13981 agttaggaaa gagttgggaa atcaactctt ttttgaaaac agaccttcat tttgaaaatc
    14041 atcaaaaaaa tggtataatg gtaggaaaag attcggctga aagtatcaga acttttagaa
    14101 taagagggta gagttgccct ataatcaaga taaactaaga ttttggagga aaaatgagta
    14161 atatcagttt aacaacactt ggtggtgtgc gtgagaatgg aaaaaatatg tacattgctg
    14221 aaattggaga gtccattttt gttttgaatg tagggttaaa atatcctgaa aatgaacaat
    14281 taggggtcga tgtggtgatt ccaaacatgg attacctttt tgaaaatagc gaccgtattg
    14341 ctggggtttt cttgacccac gggcatgcgg atgccattgg tgctctacct tatctcttgg
    14401 cagaggctaa agttcctgta tttgggtctg agttgaccat tgagttggca aagctctttg
    14461 tcaaaggtaa tgatgccgtt aagaaattta atgatttcca tgtcattgat gagaatacgg
    14521 agattgattt tggtgggaca gtggtttcct tcttccctac gacttactcc gttccagaga
    14581 gtctgggaat tgtcttgaag acatcggaag gaagcatcgt ttatacaggt gacttcaaat
    14641 ttgaccaaac ggctagtgaa tcttatgcaa ctgattttgc tcgtttggca gagattggtc
    14701 gtgacggcgt cctggctctc ctcagtgatt cggccaatgc agacagcaat attcaggtgg
    14761 ctagtgaaag tgaagttagg gatgaaatta cccaaactat tgctgactgg gaaggtcgta
    14821 tcatcgttgc agctgtttcc agtaatcttt ctcgtattca gcagattttt gacgctgcgg
    14881 ataaaacagg tcgacgtatc gtcttgacag gatttgatat tgaaaatatc gtccgcacag
    14941 cgattcgtct taagaagttg tctttagcca acgaaattct cttgattaag cctaaagata
    15001 tgtctcgctt tgaagaccat gagttgatta ttcttgagac aggtcgtatg ggtgaaccta
    15061 tcaatggact tcgtaagatg tcgattggtc gccatcgtta tgtagaaatc aaggatgggg
    15121 acctggtcta tattgctacg gctccgtcta ttgctaaaga agcctttgtt gcgcgtgtgg
    15181 aaaatatgat ttatcaggca ggtggggttg tcaaattgat tacccaaagt ttacatgtat
    15241 cagggcacgg aaatgtgcgt gatttgcagc tgatgatcaa tcttttgcaa cctaagtacc
    15301 tcttccctgt ccaaggggag tatcgtgagt tggatgctca cgctaaggct gccatggcag
    15361 ttgggatgtt gccagaacgc atcttcattc ctaaaaaggg gacgaccatg gcttacgaga
    15421 atggagactt tgttccagct ggatcggttt cagcaggaga tatcttaatt gatgggaatg
    15481 ccattggtga tgttggaaat gttgttcttc gtgaccgtaa ggtcttgtca gaggatggaa
    15541 ttttcatcgt ggctattaca gtcaaccgtc gtgagaagaa aattgtggct agggctcgtg
    15601 ttcacacgcg tggatttgtt tatctcaaga agagtcgcga tattctccgt gaaagttcag
    15661 aattgattaa ccaaacggta gaagattatc ttcaaggaga tgactttgac tgggcagatc
    15721 ttaaagggaa ggttcgagat aatttgacca agtatctctt tgaccaaacc aagcgtcgtc
    15781 cagctatttt accagtagtc atggaagcaa aataatcgtt gaaataaaca gagagaaagt
    15841 cgagtttcgg ctttttctta tagaaaaata gaaggagaaa atcatggcag taatgaaaat
    15901 cgagtattac tcacaagtat tggatatgga gtggggggtg aatgtcctct accctgatgc
    15961 caatcgagtg gaagaaccag agtgtgaaga tattcccgtc ttgtaccttt tgcacgggat
    16021 gtctggcaat cataatagtt ggcttaagcg gaccaatgta gaacgcttgc ttcgaggaac
    16081 taatctcatc gttgttatgc ccaataccag caatggttgg tacaccgata cccagtatgg
    16141 ttttgactac tacacggctc tagcagagga attgccacag gttctgaaac gcttcttccc
    16201 taatatgact agcaagcgtg aaaagatctt tatcgctggt ctttctatgg gaggctacgg
    16261 ctgcttcaaa ctggctctta cgacaaatcg tttttctcat gcagctagtt tttcaggtgc
    16321 cctcagcttt caaaactttt ctcctgaaag tcaaaatctg ggaagtccag cctactggag
    16381 aggtgttttt ggagagatta gagactggac aactagtccc tattctcttg aaagtctggc
    16441 taaaaaatcg gataaaaaga ccaaactttg ggcgtggtgt ggcgaacagg atttcttgta
    16501 cgaagccaat aatctcgcag tgaaaaatct caaaaaacta ggttttgatg tgacctatag
    16561 ccatagtgct ggaactcacg agtggtacta ctgggaaaaa caattggaag tttttttaac
    16621 aaccctacca attgatttca aattagaaga gagactgact tagtttgaac ttcagcatag
    16681 ggggagtaga actaaaataa aatatgtttt cactagactt ttcaaacgaa agtagtagaa
    16741 tagtaataaa atactggagg aaagagagta ggaaatgtac cgttatcaaa ttggcattcc
    16801 cacattagaa tatgatcagt ttgtcaaaga acatgaatta gccaatgtat tacaaagtag
    16861 tgcttgggag gaagttaagt ctaattggca acatgagaag tttggtgttt acagggaaga
    16921 aaaattactg gcgacagcta gtattttgat tagaactctt ccgctaggct ataaaatgtt
    16981 ttacatccca agaggaccta tattggatta tggggataaa gaactcttga attttgccat
    17041 tcagtctatt aagtcctatg ctcgcagtaa gagagcggtt tttgtgactt ttgacccaag
    17101 tatttgccta tctcaaagtt taatcaatca ggaaaagaca gaatttcctg aaaatctggc
    17161 tattattgat agtttgcaac aaatgggagt aaggtggtca ggaaaaacgg aggaaatggg
    17221 agacaccatt caacctcgta ttcaggcgaa aatatacaag gaaaattttg aagaagataa
    17281 actttccaag tcaacaaaac aggctattcg aacagcacga aacaaagggc ttgagattca
    17341 atatggtgga ctggaactat tagattcatt ttcggagttg atgaaaaaaa ctgagaagcg
    17401 aaaagagatt catttgagga atgaagccta ttataaaaaa ttgttagata attttaagga
    17461 caaggcctat atcaccttgg ccaccttgga tgtttctaaa cgttcgcaag aattagaaga
    17521 acagttagcg aaaaatagat ccttggaaga gacgtttact gagtcgactc gaacttcaaa
    17581 agtagaagcg cagaagaagg aaaaagaacg tttgttagag gaattgacct tcttgcagga
    17641 atatatagat gtaggtcaag cgagagttcc tttagcggct actttgagtt tggaatttgg
    17701 tactacctct gtcaatatat atgctggtat ggatgatgat tttaaacgtt acaatgcacc
    17761 aattttaaca tggtatgaaa cggctcgcta tgcctttgag cgaggtatgg tctggcaaaa
    17821 tttaggtggt gttgaaaact ctctcaatgg tggactttat cattttaagg aaaaatttaa
    17881 tccaacgatt gaagaatact tgggtgaatt tacaatgccc actcatcctc tctatcctct
    17941 gttaagactt gctcttgatt tccgtaaaac attaagaaaa aaacatagaa agtaagtata
    18001 tggcactaac aacactcacg aaagaagagt ttcagactta ttctgatcag gtttcttctc
    18061 gttcctttat gcaatctgtc cagatggggg atttgctaga aaaaagaggg gctcgaattg
    18121 tttatcttgc tttgaaacaa gaaggagaaa ttcaagttgc agctctggtt tatagcttgc
    18181 ccatgctggg tggtctgcat atggaactca attcggggcc gatttatacc caacaagatg
    18241 ctcttccagt tttttatgca gagttaaaag aatatgccaa gcaaaatggt gtattagagt
    18301 tgcttgtaaa accttatgaa acttatcaaa cttttgatag ccaaggtaat ccaatagatg
    18361 ctgagaaaaa aagtattatt caagatttga ctgatttagg ttatcaattt gatggcttaa
    18421 caacaggtta cccaggtgga gaaccagatt ggttatacta taaagattta actgaattaa
    18481 ctgaaaagag tttgcttaaa agttttagca aaaagggtaa acccttggtg aaaaaggctg
    18541 aaacctttgg cattcggttg aaaaagttaa aacgtgaaga actatcgatt tttaagaata
    18601 taacaaaaga aacctctgaa cgtagagaat atagtgataa aagtttagaa tattatgagc
    18661 atttttatga tacttttgga gaacaagcgg agtttctcat agcaagctta aatttttcgg
    18721 actatatgag caaattgcaa ggtgaacaaa ataaactaga agaaaacttg gacaaattgc
    18781 gacttgattt gagtaaaaat cctcattctg agaaaaaaca aaatcaactg agagaatatt
    18841 ctagtcaatt tgaaacgttt gaagttcgaa aagcagaagc gcgagacttg attgaaaaat
    18901 atggagaaga agatattgtt ttagctggga gtttatttgt ttatatgcct caggaaacga
    18961 cttatctctt tagtggttcc tacactgagt ttaataagtt ctatgcccct gcactgcttc
    19021 aaaaatatgt tatgttggaa agcataaaac gtggaatacc taaatacaac ttcctaggca
    19081 ttcaagggat ttttgatgga agtgatggtg ttttgcgttt taaacagaat tttaatggct
    19141 atattgtacg caaagcgggt actttctgtt accatccatc gcctttaaaa tacaaagcta
    19201 tccagttact caaaaaaata gtaggacgtt aagatgaaaa agtcagtatt tagatttctt
    19261 ttagcttctt ttagtaaaat aattcttatt tgctagaaag gtggagagac atgcgctggc
    19321 tttttcgttt gataggggct ttcttttctt ttgtgtggcg tttgttttgg cgtctggttt
    19381 ggatagttgt gctcttatgt gtgcttgctt tcggacttct ctggtatctg aacggggatt
    19441 ttcaaggagc gctaaagcaa gcagaacggt cagtaaaaat tggtcaacaa agtattgacc
    19501 aatgggagaa aacagggcaa ctgcctaagt taagccagac agatagtcac cagcattctg
    19561 aaggaaggtg ggcacaggcc tctgctcgta tttacctgga tccgcagatg gattcacgct
    19621 ttcaagaggc ttatttagaa gcaatccaga actggaatca aactggtgct tttaactttg
    19681 aactcgtgac tgagtctagt aaggcggata ttacggctac ggagatgaac gacggaggca
    19741 ctcctgtggc aggagaggcg gaaagtcaaa ctaatctctt aacagggcaa ttcttgtccg
    19801 taacggtgcg gttgaatcat tattatttgt ccaatccata ctatggctac tcctatgaac
    19861 gccttgtcca tacggcagaa catgagttag gtcatgcgat tggcttggac catacagatg
    19921 agaagtctgt catgcaacca gcaggttcct tttatggtat ccaggaagag gatgttgcaa
    19981 acctccgaaa aatatatgag actagtgagt agggtactat ctttccctac ttttttgcta
    20041 taatggaact atgaacaact tgattaaatc aaaactagag ctcttgccga ccagccctgg
    20101 ttgctacatt cataaggata aaaatggcac cattatctat gtaggaaagg ctaaaaatct
    20161 gcgtaatcga gtacggtcct attttcgtgg aagtcatgat accaagacag aggctctggt
    20221 gtctgaaatt gtggattttg aatttattgt tacggagtct aatattgagg cacttctcct
    20281 agaaatcaac ctgatcaagg aaaacaagcc caagtacaat atcatgctca aggatgacaa
    20341 gtcctatcct ttcatcaaaa tcaccaatga gcgctatcca cgcttgatta tcactcgtca
    20401 ggtcaaaaag gacggaggtc tttattttgg accttatcca gatgtggggg cagccaatga
    20461 aatcaagcga cttctagata ggattttccc ttttcgaaaa tgtaccaacc cgccctctaa
    20521 ggtttgtttt tattaccata tcggccagtg tatggcccac accatctgta agaaggatga
    20581 ggcttatttc aagtctatgg ctcaggaggt gtctgatttt ctgaaaggtc atgatgacaa
    20641 aatcatcgat gatctcaaga gtaaaatggc agtagcagca caaagtatgg agtttgaacg
    20701 tgcggcggaa taccgtgacc tgattcaggc tattggaacg cttcgaacca agcaacgggt
    20761 catggcgaaa gatttgcaaa atcgcgatgt ctttggctac tatgtggata agggctggat
    20821 gtgtgtgcag gttttctttg tccgtcaggg taagcttatc gagcgcgatg tcaatctctt
    20881 cccctacttc aatgatccag atgaggattt tttgacctat gtaggacaat tctatcaaga
    20941 aaaatctcat ctagttccca atgaggtact gattccgcag gatattgacg aagaggctgt
    21001 caaggccttg gtggattcca agattcttaa gcctcaacgt ggagagaaaa aacaactggt
    21061 caatctagcc ataaaaaatg ctcgtgttag tctagagcag aagttcaatc tgctagaaaa
    21121 atctgtcgaa aagactcaag gagctattga aaatctaggg cgtttgctcc aaatcccgac
    21181 cccagtacgt atcgagtcct tcgataactc taatatcatg ggaactagcc ctgtttcggc
    21241 tatggtggtc tttgtcaacg gcaagcctag taagaaggat taccgtaagt ataaaatcaa
    21301 gaccgtagtc gggccagacg actatgccag tatgcgagag gtcattcgca gacgctatgg
    21361 tcgagtacag cgtgaggctt tgactcctcc agatttgatt gtgattgatg gggggcaagg
    21421 tcaagtcaat attgctaagc aagtcatcca agaagaactg ggcttggata ttccaattgc
    21481 aggtctgcaa aagaatgata agcaccaaac ccatgaattg ctctttggag atccgctgga
    21541 agtggtggac ttgtctcgca attctcagga atttttcctc ctccaacgca tccaagatga
    21601 ggcgcaccgc tttgccatca ccttccaccg ccaactgcgc tccaaaaatt ctttctcatc
    21661 tcaattggat gggattgatg gtctgggacc taaacgcaag caaaatctta tgaagcattt
    21721 caagtctttg accaaaatca aggaagccag tgtggatgag attgtcgaag ttggggtacc
    21781 tagagtcgtt gcagaggctg tgcaaagaaa gttgaacccg cagggagaag ccttgcctca
    21841 agtagcagaa gaaagagtag attaccaaac ggaaggaaac cacaataaac cataaaatcg
    21901 caattttatc agatattcat ggcaatgtga cggcgctaga agcagtgatt gcagatgcta
    21961 aaaatcaagg agtcagtgaa tactggcttc tgggagatat ttttcttcct ggtccaggcg
    22021 caaatgactt agtcgccctg ctaaaggacc ttcctatcac agcaagtgtt cgaggcaatt
    22081 gggatgatcg tgtccttgag gctttagatg ggcaatatgg cttagaagac ccacaggaag
    22141 ttcagctctt gcgtatgaca cagtatttga tggagcgaat ggatcctgca acgattgtct
    22201 ggctacgaag cttgcctttg ctggaaaaga aagaaattga cggattgcgc ttttctatct
    22261 ctcataattt acctgacaaa aactatggtg gtgacttgct agttgagaat gatacagaga
    22321 aatttgacca actgctagat gcggaaacgg acgtggcagt ttatggtcat gttcacaagc
    22381 agttgcttcg ttatggtagt caagggcaac aaatcatcaa tccagggtcg attggcatgc
    22441 cctattttaa ttgggaggcg ttaaaaaatc accgtgccca gtatgccgtg atagaggttg
    22501 aagatgggga attggtaaat atcctatttc gtaaagtcgc ttatgattac gaggctgagt
    22561 tagaatttgc caaatccaag gggcttccct ttatcgaaat gtatgaagaa ctacgtcgtg
    22621 aagataacta tcagaggcac aatctggaac tattagcaag cttaatagaa aagcataggt
    22681 atgtagagga tgtgaagaat ttttttgatt ttttgtaaga gtttcctaaa ataaccaatg
    22741 caaactaaaa aagcgattgg ctgatcccat cgcttttagt atatcttata ctcaatgaaa
    22801 atcaaagagc aaactaggaa gctagccgta ggttgctcaa agcacagctt tgaggttgca
    22861 gataaagctg acgtggtttg aagagatttt cgaagagtgt tattgtaact gagattgatc
    22921 tgggaggtaa gaaccaccta gataggtatt gctgagtttt tcaagggttc cgtcttgata
    22981 gagttctttg agcgctttat caaatttctc tttaaactct ttttggtcac ttgagaaaac
    23041 gatatagttg ctggggctat ctgtagaagg taaatcaacg actgagaggt ctaaaccacg
    23101 gtccttgata atcttttgaa cggatacctt gtcaaaaact aggaaatcaa actctccgtt
    23161 agcaaggtct aggattcgtt taccaatatc ctcaccagaa aaatcaattg tagcgggatt
    23221 atcagtgtgt ttctgattcc agttattgat gaattgagcg ttagaagttc cggtatcctc
    23281 ttgtgttgtt ttaccagcga tctggtcaag agaagtcaaa ggatttttct tgttgctgac
    23341 aaggacgagg ggattgttgg aaatcggaag tgagtagagg tatttttcag cgcgctcttt
    23401 tgtgtaactc aagttattgg ccgcagcttg atagtgacca gaatcaagtc ctgggaagat
    23461 actttcccag gcggttcttt gaaattgaat ctcgtagtcg ctgagttttt catctactgc
    23521 ctttagaact tcgatatcga agcctgtcag attaccttta tcttcgtagt caaacggtgg
    23581 cacatcgcca gctgtagcaa cgacgattgt cttttgagag ctggactctt tgggtgtagc
    23641 ttgattccca caggcaacca aaaatggtag gatagctagt aataggctaa attttttcat
    23701 actgtctcca ttcaaatgta aagtacttgc tagtttatca gaaactttcc tgataaacca
    23761 atatatatct tttatgtctg tgatagaaaa acttaatcat gaaaaatccc tgcaagctct
    23821 ttcaaattat ggtagaatgg aagcagtaga attagaaaag gaaatcgatt atgaaatttc
    23881 ttgaattaaa taaaaaacgt catgcgacca agcatttcac tgataagcct gttgatccca
    23941 aagatgtgcg tacggctatc gaaattgcaa ccttggcgcc aagcgcccac aacagccagc
    24001 cttggaaatt tgtagttgtt cgtgagaaaa atgctgaact ggcaaagttg gcttatggtt
    24061 caaactttga gcaggtatca tcagcgcctg taaccattgc cttgtttaca gatacggact
    24121 tagccaaacg tgctcgtaag attgcccgtg ttggtggcgc taataacttt tctgaagagc
    24181 aacttcaata ttttatgaaa aatctgccag ctgagtttgc ccgttacagt gagcaacaag
    24241 tcagcgacta cctagctctc aatgcaggtt tggttgccat gaacttagtt cttgcattga
    24301 cagaccaagg aattggttct aacattattc ttggatttga caaatcaaaa gtcaatgagg
    24361 ttttggaaat tgaagaccgt ttccgcccag aactcttgat cacagtgggt tacacagacg
    24421 aaaaattgga accaagctac cgcttgccag tagatgaaat catcgaaaaa agataggaag
    24481 aagaaaaaat gatagcaatt gattttacag cagaagtaga aaaacgcaaa gaagacctct
    24541 tggctgactt gtttagcctt ttggaaatca actcagaacg tgatgatagc aaggctgatg
    24601 cccagcatcc atttggacct ggtccagtaa aagccttgga aaaattcctt gaaatcgcag
    24661 accgtgatgg ctacccaact aagaatgtcg ataactacgc aggacatttt gagtttggtg
    24721 atggagaaga agttctcgga atctttgccc atatggacgt ggttccagct ggtagcggtt
    24781 gggatacaga tccttacaca ccaactatca aagatggtcg cctttatgcg cgcggggctt
    24841 cggacgataa gggtcctaca acagcttgtt actatggttt gaaaatcatc aaagaattgg
    24901 gtcttccaac ttctaagaaa gttcgcttca tcgttggaac agacgaagaa tcaggctggg
    24961 cagacatgga ctactacttt gagcacgtag gacttgcgaa gccagacttt ggtttctctc
    25021 cagatgctga atttccaatc atcaatggtg aaaaaggaaa tatcacggaa tacctccact
    25081 ttgcaggtga aaatacaggt gcagcccgtc ttcacagctt tacaggtggt ttacgtgaaa
    25141 atatggtacc agaatcagca acagcagtcg tttcaggtga cttgacagac ttgcaagcta
    25201 aactagatgc ctttgttgca gaacacaaac ttagaggaga actccaagaa gaagctggcc
    25261 aatacaaggt gacgatcatt ggtaaatcag cccacggtgc tatgcctgct tcaggtgtca
    25321 atggcgcaac ttaccttgcc ctcttcctca gccagtttgg ctttgctggt ccagccaaag
    25381 actaccttga catcgcaggt aaaattctct tgaacgatca tgagggtgaa aatctcaaga
    25441 ttgctcatgt ggatgaaaag atgggtgctc tttctatgaa tgccggcgtc ttccgcttcg
    25501 atgaaacaag tgctgataat accattgccc ttaacatccg ctatccaaaa ggaacaagtc
    25561 cagaacaaat caagtcaatc ctagaaaact tgccagttgc ttctgtcagt ctatcagaac
    25621 atggtcatac ccctcactat gtgccaatgg aagatccact tgtgcaaacc ttgttgaatg
    25681 tctatgaaaa acaaacaggc cttaaaggtc atgaacaagt catcggtggt ggaacctttg
    25741 gtcgcttgtt agagcgcgga gttgcctatg gtgctatgtt cccagactca attgatacca
    25801 tgcaccaagc caatgaattt attgccttgg acgatctctt ccgagcagca gcaatttatg
    25861 ccgaagctat ttacgaattg atcaaataaa acgatagaag tctgagatct tatgcttgga
    25921 cttctttttg gagggaaagt agatgtctca aatcgaaaga atcaaacagg ctatcatggc
    25981 ggattcgcag aatgccagct atacagagcg tggcattgag cctctctttg cagcgccaaa
    26041 aactgctcgc atcaatatca tcggtcaggc tccgggactt aaaactcaag aagcaggcct
    26101 ttactggaaa gataaaagtg gtgaccgttt gcgggactgg ctaggtgtgg atgaagatac
    26161 cttttacaat tcaggttatt ttgctgtttt gcctatggat ttctactttc caggacatgg
    26221 caagtcgggt gatcttccgc ctcgtacagg ttttgcagaa aaatggcatc cgcaactctt
    26281 acaggaattg cctgatattc agttaaccct cttgattggg caatatgccc aagcctacta
    26341 tttacaggag aaaatcagtg ggaaggtaac ggagagggtg aaacactata aagactatct
    26401 gccagcctat tttccgctag ttcacccatc accacgaaat caaatctgga tggccaaaaa
    26461 tccttggttt gaggcagaag tagtgccaga tttgaaaaaa agaattaaaa cgattttata
    26521 gtcaatgaaa atcaaagagc aaactaggaa gctagtcgta ggctgctcaa agtacagctt
    26581 tgaagttgca gataaaactg acgaagtcgg taacatacgc acggtaaggc gacgctgacg
    26641 tggtttgaag agattttcga agagtattag aagaaaaaga atgaaagaaa tagcctttga
    26701 cgcattttac cagctttacc aaaacgatca gttttctcta gtggatgtga gagaagtgga
    26761 tgagtttgca gctcttcatt tagaaggtgc ctacaaccta ccgcttagtc aattggctga
    26821 tagttatgat taattggaca aagatcgctt gcattatatt atttgcaaat ctggaatgag
    26881 atcggcgcgt gcttgccaat tcctattaga acaaggttat aatgttatca atgtccaggg
    26941 tggcatgtta gcctttgaag aactttaaaa ttttgcattt ctcctacttg gtgtggactg
    27001 ggtaggagag ttttattttt agataattct tatttttaag aaaattgaaa acatttaata
    27061 tttgcctcgt gatgcttttt tcagactcct aatcgtggta tactaggtca gtattttata
    27121 aatatgaagg agatttttat ggctaaaaaa ggtaccctaa caggtttgct cctgtttgga
    27181 atattttttg gtgcggggaa cttgattttt ccgccttctc taggtgctct atctggagaa
    27241 cattttcttc ctgccatcgc aggttttgtc ttttcaggcg ttggtatcgc cgtcttgacc
    27301 cttattattg gaacgctaaa tcctaaagga tatatctacg agatttcaac gaagatagcg
    27361 ccttggtttg cgactcttta cctctcagtt ctttacttgt caatcggtcc attctttgct
    27421 accccacgta ctgctacaac agcttacgaa gtagggatta gccccctttt gtcggatgca
    27481 aataaaggac ttggcttgat tgtatttacg gttctgtatt ttgcggcagc ctatttgatt
    27541 tcgcttaatc catcaaaaat cttagaccgc attggacgta ttttaacgcc agtctttgca
    27601 attttgattg ttatcttggt cgttctggga gctatcaaat atggtggaac aagtcctcaa
    27661 gctgcttcag ctgcttatca agcttctgcc tttggtacag gtttcctaga aggttacaat
    27721 accttggacg cccttgcctc agtggccttt agcgtaatcg cagttcaaac cttgaaacaa
    27781 cttggatttt caagtaagaa agaatacatt tcaactattt gggttgttgg tatcgttgtt
    27841 gcccttgcct tcagcgctct ttacatcggt ttaggttttc ttggaaatca tttcccagta
    27901 ccagctgaag cgatgaaggg tggaacacca ggtgtttaca tcttgtcaca agccactcaa
    27961 gaaatctttg gctcaacagc tcaactcttc cttgcagcta tggttaccgt aacctgcttc
    28021 acaacgactg ttggtttgat tgtgtcaaca gctgagttct ttaatgagcg cttcccacaa
    28081 atcagctaca aggtttatgc gacagccttt accttgattg gatttgctat tgccaatttg
    28141 ggtcttgatg cgattatcaa gtactcaatt ccagtactgg ttatcttgta cccaatcacg
    28201 attgctatcg ttatgattgt cattgtcaac aaatttgttg ccctttcaaa accaggtatg
    28261 cagttgacaa ttgctgtggt tacagttatt gccattgcaa gcgtactagg aagctcgttt
    28321 aaggttgagt ttcttgcaaa tcttgttagc gttcttcctt ttgccaaggc atctctccca
    28381 tggttggtgc cagccattgt tggaatcttg ctctcattgg ttctaccaaa caagcaagaa
    28441 agcgatgttt ttgaaatgga ataatcactt aaatcacttt tgtagccaag tctacaggag
    28501 tgattttctt tttttatccg atgataaatg tgttataata ggtagcgaaa gaggtgaaga
    28561 aatgaatcaa actgtaaact atatcaaaga attaaccgct attgcatctc caacgggctt
    28621 tactcgtgag atttcagaat acctagtcca tactttagaa gaacttggtt accagccggt
    28681 tcgtacagcc aagggcggtg tcaatgtgac cattaaaggt caaaatgatg aacaacatcg
    28741 ctatgtaacc gcccatgtgg atacactcgg agccattgta cgtgctgtca aacctgacgg
    28801 acgtctcaaa ttggaccgta tcggtggttt tccttggaac atgattgagg gagaaaactg
    28861 taccgttcat gtggctagta caggtaaaac ggtatctgga actatcctta tccaccagac
    28921 atcttgccat gtctacaaag atgcaggaac tgctgaacgc actcaggaca atatggaagt
    28981 gcgtttagac gaaaaagtga ccaatgaaaa agaaacacgt gccttgggta ttgaggttgg
    29041 tgactttatt agttttgatc cgcgaacagt tgtgacggaa actggtttta tcaagtctcg
    29101 ccacttggat gacaaagtca gtgcagccat tttgctcaat ctccttcgag tttataaaga
    29161 agaaggaatt gacttgccga tgacgacaca ctttgctttt tcagtgtttg aagaagtggg
    29221 gcatggtgcc aattcaaata ttccagaaga ggtagtagaa tatctggctg tggatatggg
    29281 agctatgggc gatgaccaac agacggatga gtacacagta tctatctgtg tcaaggatgc
    29341 ttccggtcct tatcactatg acttccgtca acacttagta gctttggcga aagagcaaga
    29401 tattccattt aagctggata tctatccatt ttatggatcg gacgcttcag cagcgatgtc
    29461 agcaggtgca gaggtcaagc atgcacttct tggagcggga atcgagtcca gtcactctta
    29521 tgagcgcaca cacattgatt cagtagtggc gactgagcgt atggtagatg cctatctcaa
    29581 gagtgaggcg gtatcataga atgtgcttaa tctgtcaaag aattgaactc atcaaagctg
    29641 gagaaaatcc ctactttgtc aaagaactag aaacgggcta tgtagttatt ggagaccacc
    29701 aatactttaa gggctatacc ttatttttag caaaagaaca tgttacagaa ctccaccaaa
    29761 tggagaattc tgtaaaactt cgctttttag aggaaatgag tttggttcaa gaagcagtcg
    29821 ccaaagcatt tgaggctgaa aagatgaata ttgaactcct aggaaatggc gatgcccacg
    29881 ctcattggca tctttttccg cgaagagcag gtgatatgaa agggcacgga cttaatggcc
    29941 gtggcccagt ctggtgggtg ccctgggaag aaatggcagc agaagattgc caagtgcaat
    30001 cgccagagcg ggaagagatg attaaaatct tatctcatga attggagaag catttggcct
    30061 aagagagagg aagaaagaaa tgaaaaaaag atatgtcatt ttatctggtt tactagcatt
    30121 gactcttgca gcttgttcgc aagaaaaaac gaaagttgaa gaaaatactc aaaagacgga
    30181 gcaaagcagt caaccggaag gaactgtagg cagcaaatct caagcttcta gtcagaaaaa
    30241 ggcagaagtt agcaataaag ggagctatta tagtattcaa gggaaatacg atgaaattat
    30301 cctagctaat aaacgttatc ctttgtcaaa agactacaat ccaggagaaa atccaacagc
    30361 caaggcagag ttgctgaaac tcattgcagc aatgcaagca gctggctacc caatcagcga
    30421 tcactacagt ggttttagaa gttatgaaac tcagaccaag ctctatcaag attatgtcaa
    30481 ccaagatgga aaggcagcag ctgaccgtta ctctgcccgt cctggctata gcgaacacca
    30541 gacaggcttg gcctttgatg tgattgggac tgatggtgat ttggtgacag aagaaaaagc
    30601 agcccaatgg ctcttggatc atgcagctga ttatggcttt gttgtccgtt atctcaaagg
    30661 caaggaaaag gaaacaggct atatggctga ggaatggcac ctgcgttatg taggaaaaga
    30721 agctaaagaa attgctgcaa gtggtctcag tttggaagaa tactatggct ttgaaggcgg
    30781 agactacgtc gattaatact cttcgaaaat ctcttcaaac cacgtcagcg tcgccttacc
    30841 tactgactac gtcggttcta ttcacaacct caaaacagtg ttttgagctg acttcgtcag
    30901 ttttatctgc aacctcaaag ctgtactttg aggagcctgc ggctagcttc ctagtttgct
    30961 ctttgatttt cattgagtac aaaaaataaa cttttctctt gcaattccag ataaatagtg
    31021 tataatggat gggtatgtga aaaacatact tgtgggaggt aaaaatctct aattaccgcc
    31081 aaaaccacaa aggaggattt aaaaatggct aaaaaagtcg aaaaacttgt aaaattgcaa
    31141 atccctgctg gtaaagctac accagctcca ccggttggac ctgctcttgg tcaagctggt
    31201 atcaacatca tgggattcac aaaagagttc aacgctcgta cagctgacca agctggtatg
    31261 atcattccag ttgttatctc agtttacgaa gataaatcat ttactttcgt tacgaaaaca
    31321 ccaccagctg ctgttctttt gaaaaaagct gcaggtgttg aaaaaggatc aggtacacct
    31381 aataaaacta aagttgctac agttactcgt gcacaagtac aagaaattgc agaaactaag
    31441 atgccagatt tgaacgcagc aaacgtagag tctgcaatgc gtatgatcga aggtactgct
    31501 cgttctatgg gattcactgt tgttgactaa tcaataacac agtagaaaat ctcacagcag
    31561 tctattagtt gcttttcata ctaggcaagt gactgaggct tgtacttggg tacagcaagg
    31621 gagcttaagg ccgtaggaag agaaaaatag tagactgaaa acccgcaaga cttcatcatt
    31681 tcgagaagtg acgtgggaga tgaaaatcga ttgaaccact tacaaggaga atagaaaatg
    31741 gctaaaaaaa gcaaacaact tcgtgctgct cttgagaaaa tcgacagcac aaaagcatac
    31801 agtgtagaag aagctgtagc acttgcaaaa gaaactaact ttgcaaaatt tgatgcaact
    31861 gtagaagttg cttacaactt gaacatcgac gttaaaaaag ctgaccaaca aatccgtgga
    31921 gcaatggtat tgccaaacgg tactggtaaa acttcacgtg ttcttgtttt cgcacgtggt
    31981 gcaaaagctg aagaagcaaa agctgctggt gcagactttg ttggtgaaga tgaccttgtt
    32041 gctaaaatca acgacggttg gttggacttc gacgtagtta tcgctacacc tgatatgatg
    32101 gctcttgttg gacgtcttgg acgtgtcctt ggaccacgta acttgatgcc aaaccctaaa
    32161 actggtactg taacaatgga tgttgctaaa gcagttgaag agtctaaagg tggtaaaatc
    32221 acttaccgtg ctgaccgtgc aggtaacgtt caagcaatca tcggtaaagt atcatttgaa
    32281 gctgaaaaat tggttgaaaa ctttaaagct ttcaacgaaa caatccaaaa agcaaaacca
    32341 gctacagcta aaggaactta cgtaacaaac ttgactatca caactactca aggtgttggt
    32401 atcaaagttg acgtaaactc actttaatca gtagttaaag taatgtaaaa aagttgaaga
    32461 cgctatgtct caactttttt tgatgtacga cgggcatgtt gtatagtaga ttgaaactag
    32521 aatagtacac atctacttct aaaacattgt tagaaattga tttgactgtc ctgatcgatt
    32581 cgtcctgttc ttatttcatt ttattatata tttgaggtgt aagtcctcgg tgggcacctg
    32641 ctaccggtga acccaatagc gattcccaag tctgactatc gtgaggtagc ggattaaaac
    32701 ggtctgggga tagaccgttt taagtctgac gctggaaata agaatcgtca gaggaagaga
    32761 tagcgaaatc gtggctctac gaacaggaac gtgataataa ggcctatata gcggataagg
    32821 tatctgggtg gggggaccac tatcaattag tagctcagaa gtcggtactt aaacgtgcta
    32881 tatcaaaacc agtccttgaa aaacgtggac tggtttcgtg tttggattat taccttgaac
    32941 gacatgcgtt aaaagttagt tgaaccgccg tatgccgaac gacacgtacg gtggtgtgag
    33001 aggggctaga gattatcccc tactcgattt cgaaatctag tggaatgaat ctggaatagt
    33061 ccatcgagct ttctaatact cttcgaaaat ctcttcaaac cacgtcaatg tcgccttgcc
    33121 gtgcgtatgg ttactgactt cgtcagttct atccacaacc tcaaaacagt gttttgagct
    33181 gactacgtca gttccatcta caacctcaaa acagtgtttt gagcaacctg aggctagttt
    33241 cctagtttgc tctttggttt tcattgagta taacacattg ttagaagttg gtttaaattt
    33301 cctaatcagt ttgttcacat ttaccttcga tatattatat cccatagtta aggttggtca
    33361 tacagatgat tatagtcatg gagccgtaaa acttagtgtt tctttagttg acaaagatgc
    33421 catgaaaaaa atatctgtaa ctgtaatagg atattttgaa ataaatatag atgaaaatat
    33481 caccgatatt ctatacgtaa atggtactgc tattctttat ccttatttac gttctattgt
    33541 ttcaatagtt tcggcaattg atagcagtga agcaatgttg ctacctacca ttaatgtttt
    33601 agagttacta gataaatctc aaccttttga agaagaataa tttattagct cactaaattg
    33661 agggtaagga aaagtaaaag cagtaagaaa aatgtcttgc attatacagc aaccttttgg
    33721 gaatgagtag atggattgaa taaaatttga ttaagagtgg atgatttatc tgtagattat
    33781 tattggacag ttagtcttga agtagtctaa gaattaggtt ataatcagta gaagccttgc
    33841 taataatgag gaggttagtt tatgtatagt agactgaatc taaaatagta cgaaacaatt
    33901 gctaaaacat ttatagaaat taattttact ttcccaatcg atttgttctc atcttatttc
    33961 aatctgctat ataatagtcc atgctgtggc tggattcttt tcagcctact tgtactcttc
    34021 gaaactctct tcaaaccacg tcagcttcac tttgccgtag gtatggttac tgacttcgtc
    34081 agttctatcc acaacctcaa aacagtgttt tgagctgact tcgtcagttc tatccacaac
    34141 ctcaaaacag tgttttgagc tgacttcatc agttctatct gcaacctcaa aacagtgttt
    34201 tgagcaacct gcggctagtt tcctagtttg ctctttgatt ttcattgagt attattaaga
    34261 caatatgagg agaaagatga aagaaaaagg attttaggag ggggcgcagg cagccatgcc
    34321 aacggctctg ggctatgtca gtatcggcct ggcctgtggg actatcggtg cgccctatgt
    34381 gacacctgtt gagatgggct tgatgagtct ctttgtttat gctgggagtg cccagtttgc
    34441 catgttggca ctgattgtgg ttcaagctcc tgtggcagct attgctatga cggtttttct
    34501 aatcaacttg cgtctctttt tgttgagttt acacgcatcg acttatttcc gtcataccag
    34561 tctttggtac aatatcggta tgtctagtat cttgacagat gagacctatg gcgttttgat
    34621 gggtgaattg gcccatacag acaaggtaaa tcctatgtgg atgcacggaa acaatcttaa
    34681 cagctatgtg gcttggtttg tggggacagt agtcggaacg gctctgggtg gcctgctacc
    34741 aaatccagaa atctttggct tggattttgc cctggttggg atgtttattg gtatttttgc
    34801 ttcgcaattt cagatgatgc aaagacggat tcctgttcgc aatctgctca ttatcttagc
    34861 agttgttgcg gtgtccttct ttttactttt gacagtggtg tctcagtcac tagctgttct
    34921 gtttgcgatg ctacttggtt gtagcatggg ggtggtttta gatggtcagt aagtatcttt
    34981 tattagcggt tattttctct ggtcttgtga cctggattcc ccgtatgatt cccttcatct
    35041 tggtcaagta taagggcctg cctacgattg ttgagcgttt tttgaagttt ttgcctgttt
    35101 ccattatctt tgccttgatt ctttcaagtg tagtgacagg taaggttggg aaccttcctc
    35161 caatcaaatg actggacttc ttagcagtct ttccaatagc ttgggtagcc tttcgctacc
    35221 gcaatctagt cggaacagtt ctctttggag tggtcttgat tgccatcttg cgtttggtct
    35281 tttaaattac ccataaaaaa aacttatcac agagatagat atcatataat ggcgtaaatg
    35341 ctctttttct gttaagatta taaggtattc tattttggag gaaatgacat gaaaaaaatc
    35401 gttaaatact catctcttgc tgccctagga cttgttgctg caggtgtgct tgcggcttgc
    35461 tcagggggtg ctaagaaaga aggagaagca gctagcaaga aagaaatcat cgttgcaacc
    35521 aatggatcac caaagccatt tatctatgaa gaaaatggcg aattgactgg ttatgagatt
    35581 gaagtcgttc gcgctatctt taaagattct gacaaatata atgtcaagtt tgaaaagaca
    35641 gaatggtcag gtgtctttgc tggtcttgat gctgaccgtt acaatatggc tgtcaacaat
    35701 cttagctaca ctaaagaacg tgcggagaaa tacctctatg ccgcaccaat tgcccaaaat
    35761 cctaatgtcc ttgtcgtgaa gaaagatgac tctagtatca agtctctcga tgatatcggt
    35821 ggaaaatcga cggaagtcgt tcaagccact acatcagcta agcagttaga agcatacaac
    35881 gctgaacaca cggacaaccc aactatcctt aactatacta aggcagactt ccaacaaatc
    35941 atggtacgtt tgagcgatgg acaatttgac tacaagattt ttgataaaat cggtgttgaa
    36001 acagttatca agaaccaagg tttggacaac ttgaaagtta tcgaacttcc aagcgaccaa
    36061 caaccgtacg tttacccact tcttgctcaa ggtcaagatg agttgaaatc gtttgtagac
    36121 aaacgcatca aagaacttta taaagatgga actcttgaaa aattgtctaa acaattcttc
    36181 ggagacactt atctaccggc agaagctgat attaaataat ttcttgaaat catccattct
    36241 gagtaaggtg ggtggtttct cagtttttag ggatatagtt ttaaactata tatctgacta
    36301 tctaataaca atttgtgaaa tcaaacaaat tgtgagatac tagtacggta ttatttttaa
    36361 ggagaaagaa tcatgaaaat caaaaaatgg cttggtctag cagcccttgc tacagtcgca
    36421 ggtttggctc ttgcagcttg cggaaactca gaaaagaaag cagacaatgc aacaactatc
    36481 aaaatcgcaa ctgttaaccg tagcggttct gaagaaaaac gttgggacaa aatccaagaa
    36541 ttggttaaaa aagacggaat taccttggaa tttacagagt tcacagacta ttcacaacca
    36601 aacaaagcaa ctgctgatgg cgaagtagat ttgaacgctt tccaacacta taacttcttg
    36661 aacaactgga acaaagaaaa cggaaaagac cttgtagcga ttggagatac ttacatctct
    36721 ccaatccgcc tttactcagg tttgaatgga agtgccaaca agtacactaa agtagaagac
    36781 atcccagcaa acggagaaat cgctgtaccg aatgacgcta caaacgaaag ccgtgcgctt
    36841 tacttgcttc aatcagctgg cttgattaaa ttggatgttt ctggaactgc tcttgcaaca
    36901 gttgccaaca tcaaagaaaa tccaaagaac ttgaaaatca ctgaattgga cgctagccaa
    36961 acagctcgtt cattgtcatc agttgacgct gccgttgtaa acaatacctt cgttacagaa
    37021 gcaaaattgg actacaagaa agcacttttc aaagaacaag ctgatgaaaa ctcaaaacaa
    37081 tggtacaaca tcattgttgc gaaaaaagat tgggaaacat cacctaaggc tgatgctatc
    37141 aagaaagtaa tcgcagctta ccacacagat gacgtgaaaa aagttatcga agaaacatca
    37201 gacggtttgg atcaaccagt ttggtaataa gaaacaggga ggtgggagag agaattccac
    37261 ctcttgcttt tgtatagagc acggagtgta aagaagacta ttcgttcata gaaaggtaga
    37321 gagaatatgg tttttcctag cgaacaagaa cagattgaaa aatttgaaaa ggatcatgta
    37381 gcccagcatt attttgaggt tttgcgtacc ttgatttcta agaaatcagt ctttgcccag
    37441 caggttggac tcaaggaagt cgcaaattat ctgggtgaga ttttcaagcg tgttggagct
    37501 gaagtggaga ttgatgagag ctatacagcg ccttttgtca tggcacattt caagagttcg
    37561 cgtccagatg ccaagacctt gattttctat aaccactatg acactgtgcc agcggatggg
    37621 gatcaggtct ggacagagga tccttttacg ctttcggtcc gcaatggctt catgtatggg
    37681 cgtggggttg atgacgacaa gggtcatatc acagctcgct tgagtgcttt gagaaaatat
    37741 atgcagcacc atgatgattt acctgtcaat atcagcttta tcatggaggg agcggaggaa
    37801 tcggcttcaa cagacctaga taagtatttg gaaaagcatg cagacaaact ccgtggggcg
    37861 gatttgttgg tctgggaaca agggaccaaa aatgccttgg aacagctgga aatttctggt
    37921 ggcaataagg ggattgtgac ctttgatgcc aaggtaaaaa gcgctgatgt ggatatccac
    37981 tcgagttatg gtggtgttgt ggaatcagct ccttggtatc tcctccaagc cttacagtct
    38041 cttcgtgctg cggatggccg tatcttggtt gaaggcttgt acgaagaagt acaagagccc
    38101 aatgaacgag aaatggcctt gctagaaact tatggtcaac gaaacccaga ggaagttagt
    38161 cggatttatg gattggagtt gcctctctta caggaggagc ggatggcctt tctaaaacgt
    38221 ttctttttcg agccagcgct taatatcgaa ggaatccagt ctggttatca aggtcagggt
    38281 gttaagacta ttttacctgc agaagccagt gccaagctag aggttcgtct ggttccgggc
    38341 ctagaaccgc atgatgttct ggaaaaaatt cggaaacaac tagacaaaaa tggctttgat
    38401 aaggtagaat tatactatac cttgggagag atgagctatc gaagcgatat gagcgcacca
    38461 gccattctca atgtgatcga gttggccaag aaattctatc cacagggcgt ttcagtcttg
    38521 ccgacgacag cggggacagg acctatgcat acggtctttg atgccctaga ggtaccaatg
    38581 gttgcattcg gtctaggaaa tgccaatagc cgagaccacg gtggagatga aaatgtgcga
    38641 atcgctgatt attacaccca tatcgaatta gtagaggagc tgattagaag ctatgagtag
    38701 agatattatc aagttagatc agatcgatgt gacttttcac caaaagaaga gaaccatcac
    38761 agcggttaag gatgtgacca ttcacatcca agaaggggat atctacggaa tcgttggata
    38821 ttctggagca gggaaatcaa cccttgtacg ggtgattaac ctcttgcaaa aaccatctgc
    38881 agggaaaatt accattgacg acgatgtgat ttttgatggt aaggtcacct tgacggcaga
    38941 gcagttgcgt cgtaaacgtc aagatatcgg gatgattttc cagcatttta acctgatgag
    39001 ccaaaagaca gcagaggaga atgtagcctt tgcccttaaa cactctggac tcagcaagga
    39061 agaaaagaag gctaaagtag ctaagttgtt ggacttggtt ggtttggcag atcgtgctga
    39121 aaactaccct tcacaactat ctggagggca aaaacagcgt gtggcaattg cgcgtgcctt
    39181 ggccaatgat ccaaaaatct tgatttcaga cgagtcaact tctgcccttg accctaagac
    39241 aaccaagcag attttggcct tgttgcaaga tttgaaccaa aaattaggct tgacagttgt
    39301 cttgattacg catgaaatgc agattgtcaa agacattgcc aaccgtgtgg cggttatgca
    39361 ggatgggcat ttgattgaag agggaagtgt ccttgaaatc ttctcaaacc ctaaacaacc
    39421 tttgactcaa gactttatct caacagccac aggtattgac gaagccatgg tcaaaatcga
    39481 gaagcaagaa atcgtggaac acttgtctga aaacagtctc ttggtgcaac tcaagtacgc
    39541 tggagcttca acagacgagc cacttttgaa tgaattgtac aagcattacc aagtaatggc
    39601 taatattctc tatgggaata tcgaaattct cgatggtact cctgttggag aattggtggt
    39661 ggtcttgtca ggtgaaaaag cagcgttggc aggtgcccaa gaagctattc tccaagcagg
    39721 tgtacaacta aaagtattga agggagtaca gtaagatgga atcattgatt caaacctatt
    39781 taccaaatgt ctataaaatg ggttgggctg gtcaggcagg ctggggaacg gctatctact
    39841 taactcttta tatgacagtt ctttccttca ttatcggagg cttcttgggg ctagtggcag
    39901 gtctctttct cgtcttgaca gcgccaggtg gtgtcttgga gaataaagtc gtcttctgga
    39961 ttttagacaa aactacctca atttttcgtg cagttccctt tatcatcctc ttggcaatct
    40021 tgtcaccact ttctcacttg attgttaaaa caagtatcgg gccaaatgca gcccttgtcc
    40081 cactttcttt tgcagtcttt gccttctttg cccgtcaggt gcaggttgtc ttggctgaat
    40141 tggatggcgg tgtcattgag gcggctcaag cgagcggagc gactttctgg gacatcgtgg
    40201 gtgtttacct atcagaaggt cttccagatt tgatccgtgt gacgactgtg accttgattt
    40261 cccttgttgg ggaaacagct atggccggtg cggttggagc tggtggtatc ggtaacgtag
    40321 ccatcgctta tggatttaac cgctacaatc acgatgtgac catcttggca accatcatta
    40381 tcattttgat tatctttgca atccaattct tgggagattt cttgactaag aaattgagcc
    40441 ataaataaaa aagagccgcg tggctctttt taactgatca gattttctgt gcaaattttt
    40501 tactcaaggc ttgtccaatc aaggcaccca ctagggctcc gatgacaata cttgcgataa
    40561 atagaaggac agttccaggg tttggagcga ccatgatgcg gtcgatatat tcttgggatt
    40621 ttcctcttgc cagaagagta gccatatagg ctttgggcgc aatccacata agcaagattg
    40681 gtcctgttgt actaaaggcg aaaataatga aagaaaggaa gttctttgtt ttgtccttgt
    40741 attttcctaa atgagctact tcatctgcta ggaggccaca gataattcca ggaaggaagg
    40801 aaccagcacc gtgtttagtt cccaagaaaa agagggcaat gacaaggccg atagtggtaa
    40861 tggctccaaa gcgcggaact tttgcgacta ggatcatata gacgctaccg ccgacaaggg
    40921 cagtaaaggc aggcgcataa aacatgtttc cagtttggtc aaagagattg cccaaaagga
    40981 caccaatccc catgcagagg aagtaaagaa ctgcaaaaag cagtgtagtt aagatagatt
    41041 tcttcatgaa ttgtctcctg ataatttttt cacaattctc attttaccat ggtttggtgg
    41101 gattgtaaat ggatactaga agtttttgaa aacgcttgaa atatgatata atggtttcat
    41161 agttattttt aggggaatat catgggtaga tttttagact ttgtctttaa tcgtttcttt
    41221 ttagggatga ttgcgacagc cttcttttgg ctattaactt tagcaggagg gattatcctt
    41281 ggtctagcgc cggctagtgc caccttgatg agcttatatg cagaacatgg ttatagcttt
    41341 cgggaataca gtttgaagga ggcttggtct ctttacaagc aaaattttgt ctcaagcaac
    41401 ctgattttct atagcttttt aggtgtgggt ctagttttga cctatggttt gtatctcttg
    41461 gtgcaattgc ctcatcagac cattgttcat ttgattgcga cccttttgaa tgtcctagta
    41521 gttgccctga tctttttggc ttatacagta tctttaaaat tacaagttta ttttgccttg
    41581 tcctatcgaa atagtctcaa attatccttg attggcatct ttatgagtct agcagctgtg
    41641 gccaaggttc tccttgggac tgtgctactt gtagcaattg gttactatat gcctgccctg
    41701 ctattttttg taggaattgg gatgtggcat ttctttatca gtgatatgtt ggaacctgtc
    41761 tatgaaatca tccatgaaaa attggcgaca aaatagaatg aagcactttt ggctacatac
    41821 gcttctaaga acctatagtt cagtgatgat cattatcatt gcgagttttg caatcttact
    41881 ctcttacgct gactgggatt cacgtgaaaa ggaagcccag agagtagccc agcgtgtaac
    41941 tgctagaaca gtgagtgaaa ttgaatatta ccatagagag tcaacccaga tagctcaggc
    42001 tttagttgaa aatcaagctc gtatcgaggg aatctataaa tactttagcc ttagcatgcc
    42061 agactatttt tactggcaat tagagcggaa agcttcgcct tatatatcag tctctctgta
    42121 tgaaaatgtt gatgacctct atgttcgaaa tgattttgta actggggtgg ccattgcttt
    42181 tcaagattac aaggaagtct atgtttctac taaagacaaa cgtagtggag aaaaaatcag
    42241 ggctgaggat ttcaaaccag caggaaatag ttttgccatt ccagtgtcag atccagtgtc
    42301 agatcaagac ttaggagtga tttacatctc cttggatcct gctgttctat accatgccat
    42361 tgataatact agaggtcata ctccgatggc agtaacagtg acctcacctt ttgatacgga
    42421 gatttttcat attggtgaga cagttgataa ggagagtgaa aattggctag ttggcttaac
    42481 ttctcatggt tatcaggttc aggtggcagt tcccaaaaac tttgttttac aaggaacggt
    42541 gaccagctct gctttgattg tgggcttgag ccttctcttt attgtcattc tttatctgac
    42601 tttgaggcag acctttgcta attatcaaaa gcaggtagtg gatttggtgg attccatcca
    42661 agctattgcc caaggacaag aaggtcttcg cattgatacg cttgaaaagg atcaggaatt
    42721 gctcctaatc gcggagacga ccaatgatat gttggatcga ttggaaaaga atatccatga
    42781 tatttaccag ttagagctta gtcaaaaaga tgccaatatg cgagccttgc aggcgcaaat
    42841 caatcctcat tttatgtata atacgctgga gttcttgcgc atgtatgcag ttatgcagag
    42901 tcaagatgag ttggcagata tcatttatga attcagtagt ctcttgcgta acaatatttc
    42961 cgacgaaaga gagaccctcc tcaaacagga attagaattt tgccgtaaat acagctatct
    43021 ctgcatggtt cgctatccca agtccattgc ctatggtttc aagatagatc cagagttaga
    43081 gaatatgaag attcccaagt ttaccttgca accgctggta gaaaactatt tcgcgcatgg
    43141 tgttgaccac aggcggacag ataatgtgat tagcatcaag gctcttaaac aggatggttt
    43201 tgtggaaatt ttggtggtcg ataatggtag aggaatgtcg gctgaaaagt tggcaaatat
    43261 ccgagaaaaa ttaagtcaga aatattttga acaccaagcc agctacagtg atcaaaggca
    43321 gtctatcgga attatcaatg tacacgagcg ttttgtgctc tattttggag accgctatgc
    43381 cattacgata gagtctgcag agcaagccgg tgttcagtat cgtattacaa ttcaagatga
    43441 gtagaaaggg agaaaatgta taaagtatta ttagtagatg atgagtacat ggtgacagaa
    43501 ggtctgaagc gtttgattcc ctttgataag tgggatatgg aggtcgtcgc aacagccagt
    43561 catgccgatg aagctctaga atatgttcag gaaaatcctg tcgatgtcat catttccgat
    43621 gtcaatatgc cagacaaaac agggcttgat atgattcggg agatgaaaga gatcttacca
    43681 gatgctgcct atatcctgct ctcaggttat caggagtttg attatgtaaa aagagcaatg
    43741 aaccttagtg tggtggacta tttggtcaag cctgttgata aggtagagct gggaaatctg
    43801 ctggagaaga ttgcaggtca gctcggcgag agagggaaga aaagtcagac tcttagtcaa
    43861 gaattagacg aggctggatt tgttagttat ttaggggata aggagaattg gtggataggt
    43921 ctatccaagg aaaaacaagg ttccttcacc attccctact atgtcttggg ccaagactgg
    43981 cagattttca tttctgacca acccctagat ggtttagtcg ttacaccttt tgaagctcct
    44041 tatcaagaac actttgaacg ctggaagctg aatgctgaga aaaccctctt ttacggttct
    44101 gtaaatttgc agcagtctga gagtctcttt gcctattacg aaccgattta tagggttatc
    44161 attcagggaa atctcaatca aatcgtagaa gagttaaatc tcttggagaa ggtagttctt
    44221 gaaaatacgc cgcgtgttcc gattactaaa cagcttttta ttcagtttgt catggatgtt
    44281 ttccatttat ttgaacatct caaagctgat gacctgacag acatcgtcaa aaccattcat
    44341 gctattcaat ccttcgatga attggttcct tatatcaagg aaactctgag cagctttttc
    44401 ggtcaatacc gtatgaatga aaatgtggcc agtgtgctgg aagtcattgg tcgtgattac
    44461 caaaaagagc tttccctcaa ggatatcagt aaggctctct ttatcaatcc tgtctatcta
    44521 gggcagttga ttaagcgtga aaccgattcg acttttgcag agttactaaa caaacaacgt
    44581 attaaggctg cccaacaact tttgctttca actagtgaca gcatcgaaga tatttgttat
    44641 gctgttggtt acagtaacct tggatatttc tataaagttt tccgaaaatt gtgcggaaaa
    44701 tcgccaaaag cctaccgaaa acaggtagaa actatactat aagatttgta ttcctttaca
    44761 aaatgtgcta taatataaat attattatta ggaggttcta tcatgaaaaa gaaaccaatt
    44821 tatctatggg tcttgctaat cttgtctgcc cttatttcag ttccgtctct gtttggaatt
    44881 gtgagtccct tgcctagtaa agaagccctt cgtgctgctc agaaacaagt tgcaggggtc
    44941 aatgctcagc aattagaaga ccagcttaat tatacctata gagtagcaga agcatctcat
    45001 tctattttta atgttgcttt gattgtgcta tctactattt tagtggtcgt agcgattgtc
    45061 ttccttgttc gtaaaaattt gcaatatgca aactatactt acgttggcta tgttttgtta
    45121 gctattattg gttcgattta tggctatgtt ggtttacaag acgctgtgca gttggttcaa
    45181 gatgagagca tgcgtttgac agtgagtatt ggttcaaaag ctgttagcat tttctatatc
    45241 gtcatcaatg ttctcttcct agcccttgtc ttctataaga tgtggcgaca acagaaagcc
    45301 ttggcagaag aagaggaaac agaagagctt acctaagtat tgacaaaaaa gaactatcaa
    45361 gatacaatct tggtagttgt tttttgatta tagataaaat catggaggta catatgaaga
    45421 caatttcttt agtttatatt agtttgagtg gcaacactga aagttttgtg acgcgcttga
    45481 aagactatct cttgtcccag tacaaaggga ttgaggttca aaagattcat atcaaggatt
    45541 tggtcaagga aggcaaaaat ttctatgaaa tggaccatcc ctatgtcgct tttttgccga
    45601 cctatctcga aggtgggaat ggcgtggata acggagatgt tgagattttg acgacaccgg
    45661 tgggagattt tattgcctat ggtaacaatg ctagtaagtg ttttggtgtg gttgggtcag
    45721 gaaatcgtaa ctttaataac caatactgcc taacagccaa gcaatacagt caacgctttg
    45781 gcttccctgt attggctgac tttgaaatgc gaggcatgct ggaagatatc aaacatgtcg
    45841 cagctattat cgcagatttg tatgagttgg aaaaggagaa ttaatactca atgaaaatca
    45901 aagagcaaac taggaagcta gtcgcaggtt gctcaaagca cagctttgag gttgcagata
    45961 gagctgacgt ggtttgaaga gattctcgaa tagtataaag ttcttataag atgtggttga
    46021 agttgttcaa ctgttttttg agtataaaca gtctttaaga acgtaaaaaa gcataagttc
    46081 aggtcttcaa aaccttgttc ttatgctttt tatcatagaa atatttgctg aattttctct
    46141 tgaaatgaaa ccttatcttc atctcgcgct tgtcccttac cctgcttttc cgattgcgag
    46201 tgcgtagata aagaagatgg cgaagccaaa gaggaaaatc aatcccgcaa tggcaaggtg
    46261 tttgagccaa gaaggaagat ttttgttttc acgtgttacc aaggcgtaat tcaaaagagc
    46321 aaagaaaggt gttgtcagga aagagccaat catggcaaag cggagcatgg ttgaaacctg
    46381 accagcgaag aacttgataa tgatgatacc gatgatagca gtgatggtca tccagatgtt
    46441 caaagattta cgattgtcct ctttttgact gattagcagt cggagagatt cctgattaac
    46501 gcgagaatag ccatcgataa cagttataac tgttccaaag atacagagga aggcaataaa
    46561 agtaatcaag taacgggacc attcgccaag aacagaggca tacatgccca cgaattgaga
    46621 gatgtatttg gctgaagcag cttcaaccgc ctgccctgta ggatactgaa tcagtgctcc
    46681 cagtgccaca aagaagacgg ctaggatagc tgttccaata taaccagtgt taaagtcaaa
    46741 cagagcgtct tctgtgttaa agttgacggt ctttctcttt tcagctgacc aaagtgaatt
    46801 gatagctgaa atttcaatag gagccggcat ccatcctagg agggagacga tgaagggcag
    46861 agctgccatt tgccaaggtg tcttctcgac aaaatcagaa ctgtattctg gatgcttgac
    46921 cgccgctatg ataactgcaa gaacagtcgc aatggttaag gcagacataa tccatttgac
    46981 catgccgtct aaaagtttgt agcctccaaa gagtagcata gcccaaatga ttgcaacgag
    47041 aatgagggac cactgagtaa tgctaagtcc aatcattggg aaggcactgg cgatgatagc
    47101 tgagcacaga atggcaacac cagccgtgtt gaccatagcc gaaaagacat tgaggataaa
    47161 gaaaatccag agatagagtt ttcctttttc ggcataacct tcaaccaaag tctttccagt
    47221 atcagctgtg tattcagcac caaaacggaa aaatggatat ttaaagacat tggctaagat
    47281 gaccaagaga agtagagacc aaccgtaaga accgccagct tgagttgagg atacaatgtg
    47341 ggaacctcca acagcggcag ttgccattag gattccaggt cccattgctt ttagcttgct
    47401 tgcccaggtt gattgattta aggaaatagc ttgcgacatg ataaatactc ctttttgaat
    47461 tttcagaata atctgtatat gtaatctata ttctacaaaa aattttggaa aaatgcaaga
    47521 atattttgaa aaaagataga aaatttacaa agaaaatctg aaataactgt tatgatatag
    47581 cagattgaaa ctagaatagt acacctttgc ttctaaaaca ttgttagaaa tcgatttgac
    47641 tgtcctgatc gatttatcct gttcttattt catttcacta tagtaaggtg cagcaggata
    47701 aagaaaaacc gagaagtttc tttctcggat ttgcttatta tgaggtgcct attttctatg
    47761 ctccaagagt tgattgatgt gatctacttt tttagcctct cttttataga gaatagccca
    47821 gatgatgaga tagacaatcg caaactcgat aatgagctgg aggtagaaaa tccagtggaa
    47881 ggggaaccaa ccagcaagag ttgctagtgg gacaaagcca gccagcataa ggaagaaatg
    47941 agtcagagtg gcacgaagca tgctccagtc acggctgaat aagcagttgc caaagttgaa
    48001 gagcataccg atggctgccc agataagtgt gcagtagagc aagaccaggg caccgtgaac
    48061 ctgatgctga tccatcactt ggccgatgag agagtaggga tttagtggtg cgtaggtatt
    48121 tggtgcataa atgagtgaaa agaggatgga gaggatgagg ccgataagaa caccggcagc
    48181 tgcatcgtga aatacttgtt ttttcatagt tctaatttct ccttgatggt ttttagataa
    48241 cggcgtgaag agtaggtgaa gctttcgttt ttcaagaaaa tttctaccag accgtttggc
    48301 gtgagcttga ggtgagagat ggaatcgata ttgatgattt ctgattggga aatttggata
    48361 aaattgcttg gcaagagttt aagaacctga tagagtcgca aatcaatgct gtaggtctga
    48421 ctcgtggttt ctgctagaac cttccgattc tcgatataga agcgctgaat cttgccaatc
    48481 tcaactagat agacctgatc atcgattttt cctttgattt tttctctttg gtccagattt
    48541 tctgcgaact cgatgacttt ctggactttt tcggtttctt gaggtgcttg gacaatcagc
    48601 ttttcctcct cgtaagtctc actaatctgt agttctactt tcataaattt ctctccttgt
    48661 ttttcataca aaattaatct cacttcttgt acacctttat taatactctt caaaaatctc
    48721 ttcaaaccac gtcagcatcg tcttgccgta ggatagttgt tgactttgtc aattttatct
    48781 acaacctcaa aacagtgttt tgagctgtct gcgcctagct ttctagtttg ctctttgatt
    48841 tttattgagt ataccactat tttactccct ctggcaaggt actttgtcta tgtggaggga
    48901 ttgggctcct atgtggtgga gcttttctgt tctttctgaa atatggtata atagcactaa
    48961 tcaatttcta ggaaaataga tacagaaagg ggctgaaaga tgtctcatat tattgaattg
    49021 ccagagatgc tggcaaacca aatcgcggct ggagaggtca ttgaacgtcc tgccagtgtg
    49081 gtcaaagagt tggtagaaaa tgccattgac gcgggctcta gtcagattat cattgagatt
    49141 gaggaagctg gtctcaagaa ggttcaaatc acagataacg gttatggaat ttcccacgat
    49201 gaggtggagt tggccctgcg tcgccatgcg accagtaaga taaaaaatca agcagatctc
    49261 tttcggattc ggacgcttgg ttttcgtggt gaagccttgc cttctattgc gtctgttagt
    49321 gtcttgactc tgttaacggc ggtggatggt gctagtcatg gaaccaagtt agtcgcgcgt
    49381 gggggtgaag ttgaggaagt catcccagcg actagtcctg tgggaaccaa ggtttgtgtg
    49441 gaggatctct ttttcaacac gcctgcccgt ctcaagtata tgaagagcca gcaagcggag
    49501 ttgtctcata tcattgatat tgtcaaccgt ctgggcttgg cccatcctga gatttctttt
    49561 agcttgatta gtgatggcaa ggaaatgacg cggacagcag ggactggtca attgcgccaa
    49621 gcaatcgcag ggatttacgg tttggtcagt gccaagaaga tgattgctat tgaaaactct
    49681 gacttagatt tcgaaatttc tggctttgtg tccttgcctg agttgactcg ggctaaccgc
    49741 aattatatca gcctcttcat caatggccgt tatatcaaga acttcctgct caatcgtgct
    49801 attttggatg gtttcggaag caagcttatg gttggacgtt ttccactggc tgtcattcac
    49861 atccatatcg acccttatct agcggatgtc aatgtgcatc caactaagca agaggtgcgg
    49921 atttccaagg aaaaagaact gatgactctg gtttcagaag ctattgcaaa tagtctcaag
    49981 gaacaaacct tgattccaga tgccttggaa aatcttgcca aatcgaccgt gcgcaatcgt
    50041 gagaaggtgg agcaaactat tctcccactc aaagaaaata cgctctacta tgagaaaact
    50101 gagccgtcaa gacctagtca aactgaagta gctgattatc aggtagaatt gactgatgaa
    50161 gggcaggatt tgaccctgtt tgccaaggaa accttggacc gattgaccaa gccagcaaaa
    50221 ctgcattttg cagagagaaa gcctgctaac tacgaccagc tagaccatcc agagttagat
    50281 cttgctagca tcgataaggc ttatgacaaa ctggagcgag aagaagcatc cagcttccca
    50341 gagttggagt ttttcggaca aatgcacggg acttatctct ttgcccaagg gcgagatgga
    50401 ctttacatca tagatcagca cgctgctcag gaacgggtca agtacgagga gtaccgtgaa
    50461 agcattggca atgttgacca aagccagcag caactcctag tgccctatat ctttgaattt
    50521 cctgcggatg atgccctgcg tctcaaggaa agaatgcctc tcttagagga agtgggcgtc
    50581 tttctagcag agtacggaga aaatcaattt attctacgtg aacatcctat ttggatggca
    50641 gaagaagaga ttgaatcagg catctatgag atgtgcgaca tgctcctttt gaccaaggaa
    50701 gtttctatca agaaataccg agcagagctg gctatcatga tgtcttgcaa gcgatctatc
    50761 aaggccaatc atcgtattga tgatcattca gctagacaac tcctctatca gctttctcaa
    50821 tgtgacaatc cctataactg tcctcacgga cgtcctgttt tggtgcattt taccaagtcg
    50881 gatatggaaa agatgttccg acgtattcag gaaaatcaca ccagtctccg tgagttgggg
    50941 aaatattaaa agtataaaaa agtctgggaa aaattttcaa aatcaaaaaa acgcataaaa
    51001 tcaggtgttc aaaaaccttg attttatgcg ttttatcatg gaaatagtta cttcattttt
    51061 tcctaattct tttcgaaact ctttttaaac cacgtcagtt ttatcagtaa tctcaaaaca
    51121 gtgttttgag ctaattttgc cagttttgtc tgtaacatcg aagttgtgtt ttaccactct
    51181 gcgactggtt tcctagtttg ctctatgatt ttcacagagt attaaattgc gattttgcca
    51241 agtttcttta ttcgtctaaa agtagagtct gttctatgcg tctaatgtac gaatcaggtt
    51301 gaccatttca atagctcctt gtgcacactc agaaccctta tttcctgctt tagtaccagc
    51361 tcgttctatg gcttgttcaa ttgtatctgt cgttagcaca ccaaacataa caggaatttc
    51421 gctatttaaa ctgatttggg cgattccctt agatacctcg ctacatacat aatcataatg
    51481 acttgtattc cctctaatga cagctcccaa gcagataatt gcatcatatt ttttactttt
    51541 tgccattttt gatgcaatca gtggtatttc aaaagctcct ggaacccagg ctacctctat
    51601 atctttctcg tttacattct ctcttttgag attatctagt gctccagata ataattttga
    51661 agttataaat tcattaaatc tcgctacaac aatacctatt ttaatattgt ttgctactaa
    51721 attaccttca taagtgttca tttatttttc ctccatattt aaaatgtgac ccattcgatt
    51781 tttctttgtt tctaaataaa aactatcgta aggattggct tctatttcga ttgatattct
    51841 actggaaatg gtaattccat atttttctaa ctgttcaacc ttgtcaggat tatttgtcag
    51901 taaatgaagt gactgaagtc ccagatcttt aagcatttgt gctccaatat gatattctct
    51961 taaatcacct tcaaagccta atgcaagatt ggcatcaagc gtatccatgc cttgatcttg
    52021 taaatgatag gcttttaatt tattgataag tccaattcct cgtccctcct gtcgcaagta
    52081 aagtaagaca cccgaaccat tctcaacaat cattttcata gctttatcga attgctgtcc
    52141 acaatcgcaa cgtaaggagc ctaaaacatc ccctgttaaa cattcggagt ggacccgaca
    52201 taatacattg gcttcatcct ctatgtttcc cataataaga gcaagatgat gttccccatt
    52261 tagtttatct atatagctaa ttgctttgaa attaccgtat ctagtaggca tattgacagt
    52321 tgaaactcgt tctaccagct gatcatatac ttttctatat tcttgtaatt ctttgatggt
    52381 aattagtgga atgttgtgtt tcttcgagaa ctgaattaaa tcatctgttc tcatcatttt
    52441 gccatcatga ttcattattt cacaacatag gccacactct tttagtccag ctaattttaa
    52501 taaatcaaca gttgcttctg tgtgtccact tctttctaga acaccacctt tttttgcaat
    52561 taaaggaaac atgtgtcctg gcctgcgaaa atcagagggt gttatatctt cagctacaca
    52621 catacgtgcg gtcagtcctc tttcctcggc agaaatacct gtggtcgttt ctttataatc
    52681 aattgaaact gtaaaagcag tcttatgatt atctgtattg ttttcaacca taggtgaaag
    52741 cattaattga ttagctaaac tttcgctcat aggcatacaa attaatcctt tggcataagt
    52801 agccataaaa ttaacatttt ctgttgtagc tgcttgtgca gaacaaatta agtctccttc
    52861 attttctcta tccttgtcgt ctataacaag aacaagtcgt cccttctgca atgcttctaa
    52921 tgcttcttgt atttttcgat attccattga ctgattatcc tttctgctaa aatccatttt
    52981 gatataatag ttccttagat atttctgatt ttggagagtt atccatcagt ttttgcacat
    53041 atttacctaa gatatcattt tcaagattta ctgtactccc gacttgttta ctcttaagaa
    53101 tggtttgttc caaggtatga gggataacag atactgaaaa gtttactttg gagactttag
    53161 cgacagtcag actaatgccg tcaattgtaa tagatccttt ttcaactatt aaatctaaaa
    53221 tttctttttg tgtgttgatt tgataccata cagcattatc atcttttttt attgacgaga
    53281 tttttcctgt accatcaatg tgtcctgtaa cgacgtgacc cccaagtcga ccgttgatag
    53341 ataaggctct ttctagattc acctcacttc catgttttaa tagagtaaga gctgttcgac
    53401 tccatgtttc attcattaca tcaactgtaa aggattgatg attgaaatga gtaactgtaa
    53461 gacagatacc atttactgct atactatcgc ctaaatggat atccgttaat atttttgagg
    53521 ctttaattga tagtttacaa ttacgagagt ctttctgtat tctttcaact tttccgattt
    53581 cttcaattat tcctgtgaac atggataaat cacttcactt tctatgagat agtcatttcc
    53641 tatttgagaa aaagcataag gtttcaatct aatagcgtca tttggcaaag aaatgccttc
    53701 acctccgaca ggaaacttgg cactgcctcc aaaaattttt ggtgcaatat atattttcag
    53761 ctcatcaaca atttgttgtt ccaaagcact ccaattcatt agactgcccc cttctagaac
    53821 taggctatca atctgcatgt ttcctagatg ttgcattaaa ctcgataagt ctatatgatt
    53881 gccttttttc tttatggaaa gtatttcaca gccatgattt tgatatagct tcattttatt
    53941 tttgtcttca gaggaagtgg caatgtaagt tttaatatca tttgctgttt ttacgatttt
    54001 agaggtaaga ggagttcgta aatgtgtatc gcatatgata cggataggat ttttcccttc
    54061 ctccaatcta catgtcagca aaggatcgtc ttgaataaca gtattgactc ccaccataat
    54121 tgcactaaca tggtgtcgta actgatgcac atgctttctt gcttcttctt cagtaatcca
    54181 tttggattga tttgttttag tggctatttt tccatccatt gacattgcat atttcataaa
    54241 aacatagggt acatgctggg taatatactt tctaaaactt tttattaagt taagacactc
    54301 attttctaaa attccaacag taacttgaag attattttcc tcaagtatct ttactccttt
    54361 tccagataca ataggattac agtctaggct tccaatgact actcttgtaa taccactatc
    54421 gattatagca tctatacagg gaggtgtttt cccgaagtga caacagggtt caagtgttac
    54481 ataaagcgtc gctccgacag gggattctct acagttttta agagcatttc tctcagcatg
    54541 tgggccacca aaaaactcat gataaccttg tccgatgatg tgattatctt ttacaataac
    54601 tgcgccgacc ataggattgg ggttgacgta accagcccct ttttgtgcca gttttattgc
    54661 taatttcata tattttgaat cgctcatctc actacctcca aaaaatatac cttgaatagg
    54721 ggactactca aggcatacaa aagaaaactt atgcgattaa caaaaatgct ctgaaatgac
    54781 aagtaatcat ttcagagcac gcaaaaagca caaatatact tttatcttct ttcatccaga
    54841 ctatactgtc ggctttggaa tttcaccaaa tcatgccttt cggctcgtgg gctataccac
    54901 cggtagggaa ttgcaccctg ccctgaagat agttattcaa ttacagatga ttatagtact
    54961 taattttgaa tatgtcaaca gataaatatc gattgttttt gatatactgt atttgtgata
    55021 atcgattctc gctcctcgga taaagaaaat atgatatact agataaacga aataagagag
    55081 aaggaacact atgtacgcat atttaaaagg aatcattacc aaaattactg ccaaatacat
    55141 tgttcttgaa accaatggta ttggttatat cctgcatgtg gccaatcctt atgcctattc
    55201 aggtcaggtt aatcaggagg atcagattta tgtgcatcag gttgtgcgtg aggacgccca
    55261 tttgctttat ggatttcgct cagaggatga gaaaaagctc tttcttagtc tgatttcggt
    55321 ctctgggatt ggtcctgtat cagctcttgc tattatcgct gctgatgaca atgctggctt
    55381 ggttcaagcc attgaaacca agaacatcac ctacttgacc aagttcccta aaattggcaa
    55441 gaaaacagcc cagcagatgg tgctggactt ggaaggcaag gtagtagttg caggagatga
    55501 ccttcctgcc aaggtcgcag tgcaagcaag tgctgaaaac caagaattgg aagaagctat
    55561 ggaagccatg ttggctctgg gctacaaggc aacagagctc aagaaaatca agaaattctt
    55621 tgaaggaacg acagatacag ctgagaacta tatcaagtcg gcccttaaaa tgttggtcaa
    55681 ataggagcag agaatgacaa aacgttgttc gtgggtcaag atgaccaacc cgctctacat
    55741 cgcctatcat gatgaggagt ggggtcagcc cctccatgat gaccaagcat tgtttgagtt
    55801 gttgtgtatg gaaacctatc aggcaggcct gtcttgggaa acggtactca acaaacgcca
    55861 agctttccga gaagcctttc atagctatca aattcactca gtcgcagaga tgactgacac
    55921 tgaattggaa gccatactgg agaatccagc tatcattcga aatagagcca agatttttgc
    55981 tacacgcgct aacgcccaag cctttctaca gttacaggca gagtacggct cttttgatgc
    56041 ctatctttgg tcttttgttg aggggaaaac tgtcgttaac gatgttcctg attatcgcca
    56101 agccccagct aaaacaccct tatctgagaa attagccaaa gatctcaaaa aacgaggctt
    56161 caagttcaca ggcccagtcg ccgtattgtc ttttctacag gctgcagggc tagttgatga
    56221 ccacgagaat gattgtgagt ggagaggtct taaatgatgt ctaacaaaaa taagggaatt
    56281 ctgatttttg cgattctcta tacagtcctc tttgtgtttg atggcgttaa attgctggct
    56341 tctttaatgc catctgtcat tgcaaattat cttgtttatg tagttttagc tctatatggc
    56401 tccttcttgt tcaaggatag attgatccaa caatggaagg agattagaaa gactaaaaga
    56461 aaattcttct ttggcgtctt aacaggatgg ctctttctca ttctgatgac tgttgtcttt
    56521 gaatttgtat cagagatgtt gaagcagttt gtgggactag atggacaagg tctaaatcag
    56581 tctaatattc aaagtacctt tcaagaacaa ccactactga tagctgtttt tgcttgtgtc
    56641 attggacctc tggtagaaga attatttttc cgtcaggtct tattgcatta cttgcaggaa
    56701 cggttgccag gtttactaag cattattctg gtaggacttg tttttgctct gactcatatg
    56761 cacagtttgg ctctatcaga gtggattggt gcagttggtt acttaggtgg aggccttgcc
    56821 ttttctatta tttatgtgaa agaaaaagag aatatctact atcccctact tgttcacatg
    56881 ttaagcaaca gcctctcctt aatcatttta gctatcagta tagtaaaatg aaataagaac
    56941 aggacaaatc gatcaggaca gtcaaatcga tttctaacaa tgttttagaa gtagaggtgt
    57001 actattctag tttcaatttg ctgtaatatg tgatgaaaat accagtaatg ataccgagaa
    57061 aaaagctgag aaacttttcc cagctttatt tgttatagtc aaagcgaatg acttgttcct
    57121 gtgcatctac atgagcatgg accccaaagg gtacaattgc tcttggagtt gcgtggccga
    57181 cattcagatt atagacaatc gggatattgc tgtcaatgat atccaatagt gcctctttat
    57241 agtcgtcatg gaaagtttca tccataggtt ttccgaccaa gagtccattg atgaccgcga
    57301 atatgccagt gtcctttaaa gttagcaaca tctttttgaa gtcttctggc ttaggctttt
    57361 cttcgcttgt ttcgagcaag aggattttcc cttcccagtc tgacaagtca gggaaaagtt
    57421 tgtatttttg gcagagttcc gtgctatctg cgtatcgaga gttgtcaaag atatcgtaga
    57481 gggattcgag gcaaccaccg aggatttttc cctcgaactg agcacttcct tgcaacaagt
    57541 caaaacctgt atttgtatga ctgacacgag gtgttcccag ggccgtggga ctaaaatcag
    57601 ttcgttcctc ataccaaacg tcactagggc ggatttctga aattcttccc gtcttaatca
    57661 attctttaaa gtagtgaagg ctataggcta gcatttcttt gtctaattca caaatgtctg
    57721 ctaaaaagga ttgaccataa aaagtcttga ttcctaattt atgcaacatg aggtggttca
    57781 tggttgtatc cgagaagcca agaaaaattt tttgcttgat aaccttttgg agttggtcat
    57841 tttcaaaaag ataaggtagc aagcgatagg tatcgtctcc accgatggca cataggatca
    57901 tgtcgatgct atcatcagaa aaggcatgaa tcaaatcctc tgcacgagct tcaggatggt
    57961 ccttgataaa gtctaatcct tttaacgaat gggacaaaaa gatgggattg agtcccagat
    58021 ccttgagacg ttggataccc aagtccactt cgtgtttgac aaaatcctct ccgataatgc
    58081 cactagataa actaacaata ccaatagtag aaaccatatc tcatcctcct agaaatagat
    58141 tgagcctatt ttatcacaaa atataagaga aagctatgtg ggatttcaga agaatacttt
    58201 taatactctt cgaaaatctc ttcaaaccac gtcagtttta tctgcaacct caaagctgtg
    58261 ctttgagcaa cctgcagcta gcttcctagt ttgctctttg attttcattg aatataactc
    58321 aaaaaagtaa gtgaaaaagc aaccgcacct gcagttgctt ttatcgtttt cttattcttg
    58381 atagcgtgtt ggtcctgcac ttgcactacg gatattcaag cgtttcttga gatagaagcg
    58441 aagggctagg agggctgctc caataatagc tagtggcaat ggatccagta ctgggttaag
    58501 gctagctggt aggaagcttg ttgcaaagaa gacaagcaac caaaggaaca tagaagctag
    58561 gataactagt acagatttcc agaaaggtgg acgttgactg cgatccatat ctgatccata
    58621 gtattggtaa acaaagtagt acatcaagta gaaggcaaat ccaccaacca gtccaactaa
    58681 tagaagagta atcaatccat agccgaaagc ttggtctgcc gcaaagaagg ttgtgagggc
    58741 gctgacaagg gcaaagaggc tagtgatgaa aagagctgag tccataatca tcagttttgg
    58801 gtcatcattt tcttttggat gctctttttc gtactgctct ttgacagtga agctatgagc
    58861 ccaatgagtt ggtgcgccgt atagggaacg ggcagttgta cctttagatt gctcctcaag
    58921 gatttgggga atgacttcct caaaaatagt ctggatttca gcgtctgttt tcccatcttt
    58981 gatgaattgt tgggtagcaa tgtggacaaa ctcttggttt ttcttagtta atttttgtag
    59041 atcaatttga gacataggaa ctcctcttag aaccattttt tatggatgag atagagagtg
    59101 agcgagacac tcatagcaaa ggcgataaag acgattaacc agaaggcatt tggctctccg
    59161 tttaggggga tttcattatc cttaaagttc atcccgtagg cagaaaagac catggttggg
    59221 atggacatga cgatggtcac aagggccaag gttttcatga tgttgttctg gttgttagaa
    59281 atgatagagg caaaggtctc tgtcatagaa tgcaagacgt ttccataaat atctgccatc
    59341 tcgatggcct gttgggtttc aatcagggtg tcttcaagca ggtcttcgtc ctcaaggtat
    59401 ttcttgatat tgctggttga actggtcaat ttcttaatca cgcgctcatt tgttttgagg
    59461 gaggccttga aatagacgat agttttttcc aattccatga gctcaatcaa ttcttcatta
    59521 cgagttgatt gatgcagttg actttcgatt tgttcactct tgcggtcgat tgaacgaagg
    59581 gctgttaggt aaagctctgc attgcgataa agaatttgaa agataaaacg tgaacgcatg
    59641 aaggtataga aattacgcaa tcgacggttg ataaagacat caaggacagg tagtggttcc
    59701 aaacacgtag tgataatggt ttcctcagtg atgataatac caagcgggat ggttacgtag
    59761 taggtgcggt tatttctttc ctccgtgacc ggcacgtcta cgataatcag ggtatactcg
    59821 tcttcaatgg taatacgaga catttcttcc gcatcgagcg gtgctcgaag gtcggcaata
    59881 tcaatatcga aggtgttggc gatttcgagt gattcatttt gagtcggatt gacgagattg
    59941 atccaagtac ccggttcaag cgtatcgatc tctttaaatt cagttgttgt agagagaaaa
    60001 acttgtttca tatcccttat cctttctcat ttttcagatt ttttcacact gtactattat
    60061 actacaaaat cggccttttg ggtaatagaa tctcactttt tttggtataa tggtaagcaa
    60121 taatggacta gaaagaacaa agatgcaaga taaaattgtc attcatgggg cgcgtgccca
    60181 taatttaaaa aatattgatg tggagattcc gcgagacaag ttggttgtcg tgactggctt
    60241 gtcaggttca gggaagtcca gtctggcttt tgatactctc tatgcggagg gacaacgtcg
    60301 ctatgtagag agtttgtccg cctacgctcg tcagttcttg ggaaatatgg aaaaaccaga
    60361 tgtagatgcc attgatggtc tcagcccagc tatttccatc gaccagaaaa cgactagtaa
    60421 aaatcctcgc tcgacggtgg gaacgacgac tgaaatcaat gactatctgc gtctcctcta
    60481 cgcacgtgtg gggacgcctt actgtatcaa cggacatgga gctatcaatg cttcttctgt
    60541 ggagcaaatc gttgataagg ttttggagtt acctgaacgc cagcgcttgc agatcttggc
    60601 tcctgtcatc cgcaagaaaa aaggccaaca taagagtgtt atcgagaagg ttcagaaaga
    60661 cgggtatgtt cgtgtccgtg tggatgggga agtctatgat gtgaccgaag tgccagagtt
    60721 gtctaagagc aagcaacaca atatcgatgt cgtggttgac cgtattgtta tcaaggaggg
    60781 cattcgtagt cgtctctttg attccattga ggctgccctt cgtattgcag aaggttatgt
    60841 cattatcgac accatggacg actcggagtt gctcttctct gagcattatg cctgtccagt
    60901 ttgtggattt actgtcccag agttagaacc tcgtctcttc tctttcaatg ctccctttgg
    60961 ctcttgtagt gagtgtgacg gcttggggat taagctggag gtggatactg atttggtagt
    61021 gccagatgcc agcaaaacct tacatgaggg agcgctggca ccttggaatc ctatctcatc
    61081 caactactat ccaaacatgt tagagcaggc catgaaagtc tttggagtgg ctatggataa
    61141 gccttttgag gacctgtcag aagaagataa gaacttgatt ctctacggct cagatggtaa
    61201 ggaattccat ttccattatg aaaatgaatt tggtggtgtg cgcgatatcg acattccgtt
    61261 tgagggagtt atcaataata tcaaacgtcg ttaccatgaa accaatagcg attacactcg
    61321 cactcagatg cgtctctaca tgaatgagct gacctgcgga acctgtcaag gctatcgtct
    61381 caatgaccag gccttgtctg tccgtgtggg cggccagcaa gggccacata ttggagaaat
    61441 ctcagacctg tctatcgctg accacttgga cttggtgagc cagttaactt tgtctgaaaa
    61501 tgaagccatc attgctcgtc ccattctcaa ggaaatcaag gatcgtttga ccttccttaa
    61561 taatgtgggt cttaactatc taaccctgtc acgttcagca ggaacccttt caggtgggga
    61621 aagtcagcgc attcgtttgg caacccagat tggttccaac ctatcaggtg tcctctatat
    61681 cctagacgag ccgtcaatcg gtcttcacca gagggacaat gaccgcctga ttgccagtct
    61741 gaaaaagatg cgtgacttgg gcaatactct tatcgtggtg gaacacgacg aagataccat
    61801 gcgtgaagct gattatctga ttgacgttgg tcctggtgcc ggtgtttttg gtggtgagat
    61861 tgttgcagca ggtacaccta agcaagtggc tcgcaacagc aagtctatca caggtcagta
    61921 cttgtcaggc aaacgtgtca tcccagtacc agaagagcgc cgtgtcggaa atggtcgttt
    61981 tattgaagtg acaggagcgc gtgagaacaa cttgcaaaat gtcacggctc gctttccact
    62041 aggaaaattt atcgcagtga caggtgtgtc gggttcaggg aaatcgactc taatcaacag
    62101 cattctcaaa aaagccattg cccagaagct caaccgtaat tcagacaaac ctggtaagtt
    62161 taagactatt acagggattg agcatgtcga ccgtttgatt gatattgacc agagccctat
    62221 cggacggacg ccgaggtcta acccagctac ctatacagga gtttttgacg atatacgtga
    62281 cctttttgct cagacaaatg aagccaagat tcgaggctac aagaaggggc gcttcagttt
    62341 caacgtcaag ggaggtcgct gtgaagcttg ctcaggtgac gggattatca agattgagat
    62401 gcacttcttg ccagatgttt atgtggcttg tgaagtttgc cacggaaccc gctataacag
    62461 tgaaacccta gaagttcact acaaggaaaa gaatatttcg caggtcttgg atatgacggt
    62521 caacgatgcg gtagaatttt tccaacacat tccgaaaatt caacgcaaac tccagaccat
    62581 caaggatgta ggtctaggct atgtgacctt gggacagcca gctaccaccc tttctggggg
    62641 agaagcccaa cgtatgaagt tagctagcga actccacaaa cgctcgacag gaaaatcttt
    62701 ctacattctg gatgagccga cgacagggct tcatacagag gacattgctc gcctgctcaa
    62761 ggttttagct cgctttgtag acgccggcaa tacagtcctc gtcatcgagc acaatctgga
    62821 tgttatcaag acggcagacc atatcattga cttgggacct gagggcggtg tcggtggtgg
    62881 aaccatcatc gtaacaggaa ctccagaaga agtagctgcc aacgaagcca gctacacagg
    62941 acactatttg aaaggaaagt tacatcatga ataaacgcgt acaagcattt ctagctaaaa
    63001 tgcaagaaaa agaactagat ggtatcatca tcaacaatct taaaaacgtc tattatttga
    63061 ctggtttttg gggctcaaac ggaacagtct ttatcagccg tgaccgtcag gtcttagtga
    63121 cagactctcg ctatatcatc gcagctaagc aagaaaccag tggttttgag attgtggctg
    63181 atcgtgatga attggctgtc attgcaggaa ttgttaagga catgaacttg actcgtatcg
    63241 gttttgaaga tgagatttca gtgtcttatt accaccgtat gcaggcagct tttgcaggtt
    63301 tgaacttgct tccacaaact cagtttgtgg aaggtcttcg tatgattaag gatgaggcag
    63361 agattgcagc gattcgcaag gcttgttcta tctcagacca agctttccgc gatgcgcttg
    63421 actttatcaa accaggaaaa actgaaattg agattgccaa cttccttgat ttccgcatgc
    63481 gtgagttggg agcatctggc ttatcttttg atacgatcct agctagcggt atcaattctt
    63541 ctaaacccca tgcccatcca atgcacaaac cagtggagtt gggagaagcc atcaccatgg
    63601 acttcggctg tctctatgac cactatgtca gtgatatgac ccggactatc tatctagggc
    63661 atgttagcga tgagcaggca gagatttaca atacggttct aaaagctaac caagccttga
    63721 ttgaccaagc taaggcaggc ttaggtttcc gtgactttga caaaatccct cgtgatatta
    63781 tcattgaggc aggttatggt gactacttta ctcacggcat tggccacggt attggtctgg
    63841 atatccatga ggaaccctac tttagtcaga cttctacaga aactattaag acaggtatgg
    63901 ccttgaccga tgaaccaggt atctatatcg aaggcaaata tggcgttcgt atcgaggatg
    63961 atatcctgat tacagagaca ggttgtgaat tattgaccct agctccaaaa gagttgatag
    64021 tcatttagtt gtttgtcaag aaaaaagtac gaaaatgacg aaaaaagtca aaaaaaatta
    64081 aaaataggtc gcaagtcgga tgttttttat ggtataatag actaaactga tagtaacatg
    64141 tagcgaaagg ggtaggtaca tgattaaaat ttatacagtc tcaagttgta ctagctgtaa
    64201 aaaagcaaaa acctggctca atgcccacca gttaagttat aaagaacaaa accttggtaa
    64261 agaaggaatt acgagagaag aattactgga tattctaacc aaaacagata acggaatagc
    64321 cagcatcgtt tcgtctaaaa atcgctatgc caaagccctt ggagtggata ttgaagattt
    64381 gagtgtcaat gaagttctca atctgattat ggaaacaccg agaattttaa agagcccaat
    64441 ccttgtagat gaaaaacgcc tgcaagttgg ctacaaggaa gacgatattc gtgccttcct
    64501 accacgctct gtccgtaatg tagaaaatgc agaagcacgt ttgcgtgcag ctctataaac
    64561 atcaaggctg ggagcacttc ccagtcttat tctattttaa tttcaaaaag aaagaagaaa
    64621 gaaatgaaaa aaatagttct tgttagtcta gctttccttt ttgtcctggt tggttgcgga
    64681 cagaaaaaag aaactggacc agctacaaaa acagaaaaag atacgcttca gtcggcattg
    64741 ccagttattg aaaatgctga gaagaataca gttgtaacta agactttggt cttgcccaag
    64801 tcagatgatg gtagccagca gacacaaaca attacttaca aagacaagac ttttttgagt
    64861 ctagctatcc aacaaaaacg tccagtctct gatgagttga agacttatat tgaccaacat
    64921 ggagtggagg aaactcaaaa agctcttctt gaagcggagg agaaggataa gtctatcatt
    64981 gaagctcgta aattggcagg tttcaaactt gaaacaaaac tattgagcgc aacggaactt
    65041 caaacaacga ctagttttga ttttcaagtt ctggatgtca agaaggcttc ccagttggaa
    65101 catctgaaga atattggttt ggaaaatctt ttgaaaaatg aaccaagcaa atatatttca
    65161 gatagattgg caaatggcgc gacagaacaa tagaaaatcc aaataaatag actgcctgaa
    65221 ttgtagaagg taaggaatta tgctataatg gtactattct aaggaaagag ggtgttagaa
    65281 tgggatttac tgaagaaaca gtacgtttta aattggacga ttccaataaa aaagaaatta
    65341 gcgaaacttt gacagatgtt tatgcttcgt tgaacgataa gggttacaac ccaattaacc
    65401 aaatcgtagg ttacgtattg agtggagacc ctgcctacgt tcctcgttat aataatgcac
    65461 gaaatcaaat ccgtaagtat gagcgtgatg aaatcgttga ggaattggtt cgctactacc
    65521 tcaaaggaca aggagtcgat ctataaccta tgagaattat gggattggac gtcggttcaa
    65581 aaacggtagg ggtggcgatt agcgatccgc ttggttttac agctcaaggg cttgaaatca
    65641 tccagataaa tgaagaacaa ggccaatttg gttttgaccg cgttaaggaa ttggttgata
    65701 cttacaaggt ggaacgattt gtagtgggct tgcctaaaaa catgaacaat acaagtggac
    65761 cgcgcgtaga agctagtcaa gcctacggag caaagctaga agagtttttt ggtttaccag
    65821 tagactatca ggatgaacgc ttgacaacag tggctgctga gcgcatgttg attgaacaag
    65881 cagatatcag tcgcaataag cgcaagaaag tcattgataa gttagcagct cagctgattt
    65941 tacaaaatta tttagataga aaattttaat ataaaggaga ggctatgtca cacgatcata
    66001 accacgacca cgaagaacgt gaactaatca cactagtaga tgagcaagga aatgaaacct
    66061 tgtttgaaat ccttttgaca attgatggaa aagaagaatt tggtaaaaac tatgttcttc
    66121 tagtaccagt taacgcagaa gaagacgaag acggacaagt tgaaatccaa gcttactcat
    66181 tcattgaaaa tgaagatgga acagaaggcg aattgcaacc aatcccagaa gactcagaag
    66241 acgaatggaa catgattgaa gaagtcttca acagctttat ggaggagtga tacagtctgg
    66301 gagactgtat cagcccaact cccagaaatg gggaagagtt ggaacgtcca gtgaacattt
    66361 ttaccccata ttcacattca tagtggctag ttattagcta atcaggtaag aggtcgggac
    66421 gaaaatcctg gccttgtttt tattagtaac catactttaa tgcgataatt gattggactt
    66481 ttgtcaagga gatgtgtatg tttgaagtag aagaatggct ccatagtcgg attggtttga
    66541 attttcgatc aggtttgggc cgaatgcagc aagcggtgga tttgttagga aatcctgagc
    66601 agtcttaccc tattatccac gtaacaggga ctaatgggaa aggatctacc attgctttta
    66661 tgagggaatt atttatgggg catggcaaaa aagttgcgac ctttacctcc cctcatatcg
    66721 tctctatcaa tgaccgaatc tgcattaatg ggcaacctat agcagacgca gactttatcc
    66781 gtttgactga tcaggtcaag gagatggaga aaacgcttct gcaaactcct gcccagttgt
    66841 ccttttttga attgctgacc ttagttgctt ttctttattt tagggagcaa gaggtggatt
    66901 tggttttatt agaagtggga attggtggct tacttgacac gaccaatgtg gtaactggag
    66961 agcttgctgt catcacctcc attgggcttg accatcaaga aaccttgggt gatagtctag
    67021 aagcaattgc agagcagaaa gctggtattt tcaaggctgg taagaaggca gtgattgcga
    67081 aattgcctcc agaagctagg cttgtctgtc agaaaaaagc cgaatcttta gctgttaacc
    67141 tttatcaggc aggtcaagat tttttaatgc tgaatggtga tttttcaagc tctttactaa
    67201 atctttcaca gctgaacata ggcttagaag gagtctatca gcaggagaat gcagccttgg
    67261 cgttgcaaac ttttcttctt tttatgggag aaggaaagga agctgttgat gaacaggctg
    67321 taagaaaggc cttggaacag acccattggg ctggtcgctt ggagcgtatt cgcccacaga
    67381 tttacttgga tggtgctcat aacctccctg ccttgactcg cttggttgag tttatcaaag
    67441 aaaaagagca ggaaggctat cgacctcaaa tcctctttgg atccttgaaa cgtaaggatt
    67501 atcaagggat gttgggttat ctgactgaaa atttacctca agtggaactc aagatgactg
    67561 gctttgacta tcaagggtct ttggacgaga cagatgtaac aggttaccat gtaattccct
    67621 cttaccgaga atttatcagc agtttcgaag aaagggcaga cgctcaagac ttgctgttcg
    67681 ttacagggtc tctctatttt atctcagaag tacggggcta cctgctggac cgtgagcaga
    67741 taaattgact ccattttttg aacttgttat actaggggaa ttgctggtta gagaaaattt
    67801 ctctaaattg gtagcagaaa ggaaattcat catgaaatta aaaagattca cactttctct
    67861 tgcttctcta gcaagtttta gtctcttagt agcttgttca caaagagctc aacaggttca
    67921 acagcctgtt gctcagcagc aggtccaaca acctgctcaa cagaatacca atactgcaaa
    67981 tgcaggaggt aaccaaaatc aagcggctcc agtacaaaac caacctgttg ctcaaccgac
    68041 cgatattgat gggacttata ctggtcagga tgacggagac cgtatcactt tagtggtaac
    68101 tggaacgact ggtacatgga ctgagctcga atctgacggg gatcagaaag tcaaacaggt
    68161 tacattggat tcagcaaatc aacgcatgat tattggcgat gatgtcaaaa tttacactgt
    68221 aaacggtaat caaatcgtcg tagatgatat ggatagagac ccatcggacc aaatcgtttt
    68281 aactaaataa gactatgcaa gtagaaaggg ctggattttt cagccttttt acttttacct
    68341 agaaaataat cataaatact tgccttctac cgaatacctg cgttatacta gtatcaatta
    68401 cttgttttta gcattcaaac tatcaaggag gggatatgaa atataggaaa tttcagttat
    68461 tgatgtccaa gtatggcttt agtctttcga ttatgctact tgaactttgt cttgtttttg
    68521 gtctctttct ttatttagga cgcatggctc ccattttatg gattactgtc ctcattctac
    68581 tgagtatcat cacaatcatt tcgatagtca accgtaatac gactcctgag aataaggtaa
    68641 cctggttgtt agtagccttt gtaccagtat ttggtccctt gctctatctg atgtttggtg
    68701 aaaggcgatt gtccaaaaaa gaaatcaaac aactgaagaa gctaggctct atgcatttcc
    68761 aagaagcaaa tagccagcta ctaaaagaga aattaaaaga aagtgacaag gcagcttatg
    68821 gagtcatcaa gtccttattg agtatggata ccaatgctga catctatgat caaactgcct
    68881 ctacattttt tcctaacgga gaagctatgt ggaaaaagat ggtagaagat cttaaaaagg
    68941 ctgagaaatt tattttcttg gaatattaca ttatagaaga aggtttgatg tggaatcgca
    69001 tactagatat actagagcaa aaggtagctc agggtgtaga ggttaagatg ctctatgatg
    69061 atatcggctg tatggctact ttaacaggag attatgcaca tcgacttcgt cagctgggca
    69121 tcgaggccca taaattcaat aaagttattc ctcgtttgac agtggcttat aataacagag
    69181 atcatagaaa aatattgatt gttgatggtc agatagccta tactggtggg gtcaatctgg
    69241 cagatgagta cattaaccac gtcgagagat ttggttattg gaaggatagt ggaattcgct
    69301 tagacggact agcagtaaaa gccctgacac gcttattttt gaccacttgg tacattaatc
    69361 gaggagaaat tagtgatttt gatcaatatc atttagaaaa tcattctatc ccgagtgacg
    69421 gtttaaccat tccatacgga agtggaccca agccaatttt tcgagcgcag gtagggaaaa
    69481 aagtttatca gagtttaatc aatcaagcaa cggaatcggt ctatattacg acaccttatt
    69541 tgattataga ttatgattta acagagacaa tcaaaaatgc agctatgaga ggggtcgatg
    69601 ttcgaattat caccccttac ataccagata agaagttcat tcagttagtc acgagaggag
    69661 cttatcccga ccttctttct gctggtgttc ggatttatga gtatagtcca ggttttattc
    69721 atagtaagca gatgttggta gacgaagatt ttgcggtggt ggggacaatc aatctcgact
    69781 accggagctt ggtacaccat tatgaaaatg cagtcttact ctataaaact ccttctataa
    69841 gggaaatcgc ccgagatttt cgaaatatat ttgcagattc tcaggaagtc tatcctcatt
    69901 ctatcaaaac gagctggtat caaaagcttg taaaagaaat cgcccagcta ttcgccccta
    69961 tcttataaga aatctagaac ttaggataca aaccagacct atttttcttg tcttttacga
    70021 atagaaagaa agaggagggg aattcatgct aactaaggaa gaagtgaatg atatgattga
    70081 gttcaaacag acacatttac accgctttcg ggaaattgaa acctttgtga aactatgcaa
    70141 aaaatcactc aaacagccat cgcaagctga caatcctagg actttttgat atactaagac
    70201 agataaattg aacaggagaa acgatatgag tgtgtatggt agagtagaag aagttcataa
    70261 ggagaatcgt gaacctctag aataccaaat cgaacaagaa tcgcatcatc gtgaatcaag
    70321 tcgtcttcct ttggtgaaaa ttttactatg gagtacgctt gtaacgggga taactctagg
    70381 agtaccgcta ttactcgact taatgagtgc acaagaagtg caggattttt atgcaggttg
    70441 ggcgcttcat cagacaggga agatttacag cgactattat ggaagtcaag gtttgcttta
    70501 ttatttgctg acttacgtga gtcagggcgg atttttcttt gccatctttg agtggttagc
    70561 cttggtagca ggaggatttt tcctttttag atcagcggac accttgacag agcaaggaga
    70621 ccaagctgga catctggtga ctatttttta catgctagtt acaggtcttg cttttggtgg
    70681 aggctatgcg actcttttag cgcttccttt cttattcgca gcctttagtt tagttgcggc
    70741 ttacctaagc aatccaagcc atgataaggg atttgtacgg attgggctag ctttggcagg
    70801 cggatttttc tttgctccct tatcatcgct cctgtttatt gctgtagtga gtttaggctt
    70861 gttggtcttt aaccttgggc atagacgctt tgcgcatggg ttttatcagt ttcttgcagt
    70921 ggctttaggt ttttcacttg tcttttatcc aactgcctac tatagtgctg caacaggaag
    70981 ttttggggat gcgattagtg gtattcgtta tcctattgac agtattcgct ttgattttac
    71041 ttctaaaatt ttagagaata tgttttttta tggcttgttg tcccttggtt tgggatttgt
    71101 ggtttgtatc tttttaggtc tctttcaatc caaacccttt aaactatacg tcatttcggt
    71161 tcctgcaagt cttgtggtaa ttttaggttt gattttactt ttcttttcac aagagcctct
    71221 gcacgcttct tatttgatgg tcgtcttccc tgttttccta cttttattgg taaccaatat
    71281 taagagtcaa cagagggggc gtagtgctag aagaagccga agagaaacgc cagttagcct
    71341 atggagtcgt ttcttcaaag gaaatctata tctgctagtt tttgggtttg tctatctttt
    71401 gtctgttcct tttttgatga agtttgtcct ttatccagta ccttatcaag aacgtaatcg
    71461 tcttgctgat ttggtaaaag aggagacaaa tacggaagat gctatctatg catgggatga
    71521 tactgcgact ctttatcgta agagtgagcg cttgtcgcca tcggcgattt tgtccccgtt
    71581 gcactataca gcaactgagg aaaatcgtaa taagttactt aatgacttga aagaaaaaca
    71641 acctaaggtg attgtggtaa atgacaaggt ggtagtctgg tctgaagtgg aaacactctt
    71701 aaaagaaaat taccaacaag taaagactga ttactcagag tttaaagtct ataaaattaa
    71761 ataaccaaat caatatcttg tgtattttta aaaattttag gatttttaac acaagatatt
    71821 gatttttctt tttagagtgg tataatactt tttagaaaga acattttaga aaagagcatg
    71881 catatgattg cactagaaga aaaaattaca attttgccaa ctctcttcgt cgagaaacga
    71941 gatgggagac gtgttgtatt tgatgtggac aagattgaca aggctctcca caaggcggct
    72001 gacaaggtta tggatgtgac acccctggtt gaaaaacgcc tcaatgatct gactgagcga
    72061 attattacag aaattcatag tcgctttcca cagggaatta agatttacga aattcaaaat
    72121 atcgtagaac atgaactcct tgaagccaaa gaatatgcgc tggctgagga gtatattact
    72181 tatcggacac agagggattt tgagcgctca aaagcgacgg atatcaactt tagtattcat
    72241 aaacttctca acaaagacca gacagttgtc aatgaaaatg ctaataaaga cagtgatgtc
    72301 tttaacactc agcgtgattt gacagcaggg attgttggga aatcaatcgg actgcaaatg
    72361 cttcctaagc acgtagccaa tgcccaccaa aagggggata tccactatca cgatttggac
    72421 tacagtccct atacccctat gaccaactgc tgtttgattg attttaaggg tatgttggaa
    72481 aatggtttta agattggaaa tgcagaggta gagagtccca agtctatcca gactgcgaca
    72541 gcacagattt ctcaaatcat tgccaacgtt gcttctagcc agtacggtgg ctgttcagct
    72601 gaccgtatcg atgaaatttt ggcgccttat gcagagaaga actatcaaaa acatctcaaa
    72661 gatgcagaag agtgggtatt gcctgaaaaa cgggaagatt acgcttggaa gaaaacgcaa
    72721 aaggacatct acgatgccat gcaatctctt gagtatgaaa tcaatactct ctttacttca
    72781 aatggacaaa caccttttac ttcgctaggt tttggtctgg gaaccagtcg ttttgaacga
    72841 gaaattcaaa aagctatttt aaacattcgc atcaagggtc ttggttcaga acaccgtacg
    72901 gctatctttc ctaaacttat ctttacgctt aaaagaggcc tcaacttaga ggaaggaact
    72961 cccaactatg acatcaagca gttggctcta gagtgtgcaa ccaagcggat gtatccagac
    73021 gtcttgtctt atgataagat tgttgatttg acaggttctt tcaaggtgcc tatgggctgc
    73081 cgttctttcc ttcaagggtg gaaggatgaa aatggtgtag aagtcaattc aggtcgcatg
    73141 aatctgggtg ttgtgacggt taatctgcct cgtattgctc ttgagtctga aggtgatatg
    73201 aataagttct gggaaatctt caacgagcga atgaatatcg cagaagatgc tcttgtttac
    73261 cgtgtcgaac gcactaaaga ggcgacacca gcgaatgctc ctattcttta tcagtacggt
    73321 gcttttggcc atcgtctagg taaagaagaa agtgttgacc agctctttaa gaatcgtcgt
    73381 gcgaccgttt cgctgggcta tatcggcttg tatgaagtag cgacagtttt ctttggtaac
    73441 agctgggaaa gtaatccaga tgctaaggaa ttcacgctag acatcattca cgatatgaaa
    73501 cgccgtgtag aagagtggtc agaccaatat ggctaccatt tctctatcta ctcaacacca
    73561 tccgaaagtc tgacagaccg tttctgccga ctagatatag acaagtttgg ctctattcct
    73621 gatatcacag acaaggaata ctacaccaac tctttccact acgatgttcg taaaaatcca
    73681 acaccgtttg aaaaattgga ctttgagaaa gtctatccag aagcaggtgc gtcaggtggt
    73741 ttcatccatt attgtgagta tccagtcctt cagcaaaatc caaaggcctt ggaagctgtc
    73801 tgggattatg cttatgaccg tgtaggctat ctaggcacca atactccgat tgaccgttgc
    73861 tacaagtgtg actttgaagg ggattttgaa ccaactgaga gagggtttgc ttgtccaaac
    73921 tgtggcaata gcgatcctaa aacagtagac gttgttaaac ggacttgtgg ctatcttggc
    73981 aatcctcaag cgagaccaat ggttaacggg cgtcacaagg aaatcgctgc gcgtgtcaaa
    74041 catatgaatg gttcaacgat taaaatagct gggcatcaag taacaaatta gaaagaaatg
    74101 aaatgggaaa atatcaacta gacgataagg ggcgcgcaca agtgacccgt tatcacgaga
    74161 aacactctaa aggtggagct ggtaagaaag aacgcttgct tagcttcaga gaacaatttt
    74221 taaacaagaa caagaaaaaa taaaagtgag agccagctct cgcttttctc atagtgggag
    74281 gtagggatgg aattacgcag accaagatta gcggataaga aagctgtttt agatatgatg
    74341 acagagtttg aaaagagcca atcagcccat gatggaggat tttgggatgt tgaggatttt
    74401 tcttacgagg agtggctaga aggtaaccgt aataaagaaa tgggaatatg gctacctgaa
    74461 aatcgcgttc catcgataca gttcgtattg tttggtgaat caggttgtgc tctaggattt
    74521 ttgaatctgc gattgagact gaatgagggg ttactgaatt atgctggcca cattggctac
    74581 tccattcgtc catctgaaag aggcaagggt tatgcaaaag agactctccg tcagggcttg
    74641 caagttgcta aggaaaagaa catcaagaaa gctctggtga cctgtagcgt gaataatcct
    74701 gctagcagag cagtcattct agcaaatggt ggaatatttg aggatgctcg caatggagtc
    74761 gagcgttatt ggatagaggt agcgaatgaa taatccaaaa ccacaagaat ggaaaagcga
    74821 ggaacttagt caaggtcgta tcattgacta caaggccttt aactttgtgg acggagaagg
    74881 cgtgcgcaac tctctctatg tagcaggttg catgtttcac tgcgaggggt gttataatgt
    74941 agcgacctgg tccttcaatg caggcattcc ctatacagct gagttggaag aacagattat
    75001 ggcagatctt gcccagcctt atgttcaggg gttaacctta ctaggagggg agccttttct
    75061 taatactggg attctcttgc cacttgttaa gcggattcgg aaggaattgc cagacaagga
    75121 catctggtcc tggacgggct acacttggga agaaatgatg ttggaaactc cagataaact
    75181 ggaactcttg tcactgattg acattcttgt cgatggaaga tatgatcgaa ctaagagaaa
    75241 tcttatgctc cagtttcgag gttcgtccaa ccaacgaatt atcgatgtgc aaaaatcgct
    75301 caaaagtggg caagtagtga tttgggacaa gctcaatgac ggaaaagaaa gctatgaaca
    75361 ggtgaagaga gaatgaagaa aaaagactta gtagaccaac tagtctcaga gatcgagacg
    75421 gggaaagtca ggacactggg aatatacggt catggagctt caggtaaatc aacctttgca
    75481 caggaattgt accaagcttt agattctact acagtaaatt tgctagagac agatccttat
    75541 atcacctcag gacgccatct ggtagtaccc aaggacgcgc cgaatcaaaa ggtgacagcc
    75601 agtctgccag tggcgcatga actggagagt ttgcagagag atatccttgc cttgcaggcg
    75661 ggtatggatg tcttgacaat tgaagaacct tggaaggcta gtgaggtctt gtctggagcc
    75721 aaaccaattt tgattgtcga agggatgtct gttggctttc tacccaagga actctttgaa
    75781 aaaaccatct gtttctacac ggatgaggag accgaattaa agcgacgcct tgctagagat
    75841 acgactgtga gaaatcgcga tgcatccttt atattggcta gccatcagat gagacgggag
    75901 cagtatctgc gatactataa agaaactgag tctaaggcgg atatcttagt ggaccaatca
    75961 gaagataaat ttgatgtcaa gaggacttaa cttatgtata gaatgtatag aagaaatata
    76021 gaagaaaatc cctaatttta gaaagaaaaa gtaggaaaac agtttcatcc caaaaaaacg
    76081 aaaaaacagc aacaaatccc ttgcaatcgc aggggctttg tgttattcta ttatggtgct
    76141 gtaaattaca gccttagttt tgatgcaaga ggttgcgaca cgctcggttg cattgccacg
    76201 caacaccgcg tcggttttct tgtggagcta gcctattatc ttaaatagac gaaaaggaga
    76261 aaaagatggc aaacaaaaaa atccgtatcc gtttgaaagc ttacgaacac cgtacgcttg
    76321 acacagcggc tgcaaaaatc gtagaatcag ctactcgtac aggtgcacaa gttgcgggtc
    76381 caatcccact tccaactgaa cgtagcctct acacaatcat tcgtgcgact cacaaataca
    76441 aagactctcg cgaacaattt gaaatgcgta cacacaaacg tttgatcgat atcgttaacc
    76501 caactcaaaa aacagttgat gccttgatga aattggatct tccaagtggt gtaaacgtag
    76561 aaatcaaact ttaatctaaa atataaaaga gcagaggctg gtgtttcaat ctaattgaac
    76621 acgggctaaa ctcggtgtga aaaagataaa cttcctagtg tctgctagac actgcgtcag
    76681 tttcctattt tgacgttgag tttgacgtcc tttgtatctt agacttgagc ataaaaaacg
    76741 ctcgttaaaa actttttgaa taaaaaatat agaaaaggaa ctattttctc atgacaaaag
    76801 gaatcttagg gaaaaaagtg ggaatgactc aaatcttcac tgaagctggc gaattgatcc
    76861 ctgtaacagt tattgaagca actccaaacg ttgttcttca agttaaaact gttgaaacag
    76921 acggatacaa cgctatccaa gttggtttcg atgacaaacg cgaagtattg agcaacaaac
    76981 ctgctaaagg acatgtagcg aaagctaaca cggctcctaa gcgcttcatt cgtgaattca
    77041 aaaacgttga aggcttggaa gttggcgctg aaatcacagt tgaaacattc gcagctggag
    77101 atgttgttga cgtaacgggt acttctaaag gtaaaggttt ccaaggtgtt atcaaacgcc
    77161 acggacaatc acgtggacca atggctcacg gttctcgtta ccaccgtcgt ccaggttcta
    77221 tggggcctgt tgcacctaac cgcgtattca aaggtaaaaa ccttgcagga cgtatgggtg
    77281 gcgaccgcgt aacaattcaa aaccttgaag ttgtacaagt tgttccagaa aagaacgtta
    77341 tccttatcaa aggtaacgta ccaggtgcta agaaatctct tatcactatc aaatcagcag
    77401 ttaaagctgg taaataataa agaaagggga aatcagtcac aatggcaaac gtaacattat
    77461 ttgaccaaac tggtaaagaa gctggccaag ttgttcttag cgatgcagta tttggtatcg
    77521 aaccaaatga atcagttgtg tttgatgtaa tcatcagcca acgcgcaagc cttcgtcaag
    77581 gaacacacgc tgttaaaaac cgctctgcag tatcaggtgg tggacgcaaa ccatggcgtc
    77641 aaaaaggaac tggacgtgct cgtcaaggtt ctatccgctc accacaatgg cgtggtggtg
    77701 gtgttgtctt cggaccaact ccacgttcat acggctacaa acttccacaa aaagttcgtc
    77761 gcctagctct taaatcagtt tactctgaaa aagttgctga aaacaaattc gtagctgtag
    77821 acgctctttc atttacagct ccaaaaactg ctgaatttgc aaaagttctt gcagcattga
    77881 gcatcgattc taaagttctt gttatccttg aagaaggaaa tgaattcgca gctctttcag
    77941 ctcgtaacct tccaaacgtg aaagttgcaa ctgctacaac tgcaagtgtt cttgacatcg
    78001 caaatagcga caaacttctt gtcacacaag cagctatctc taaaatcgag gaggttcttg
    78061 cataatgaat ttgtatgatg ttatcaaaaa acctgtcatc actgaaagct caatggctca
    78121 acttgaagca ggaaaatatg tatttgaagt tgacactcgt gcacacaaac ttttgatcaa
    78181 gcaagctgtt gaagctgctt tcgaaggtgt taaagttgcc aatgttaaca caatcaacgt
    78241 aaaaccaaaa gctaaacgtg ttggacgtta cactggtttt actaacaaaa ctaaaaaagc
    78301 tatcatcaca cttacagctg attcaaaagc aatcgagttg tttgctgctg aagctgaata
    78361 atctaaggag gaaatatcgt gggaattcgt gtttataaac caacaacaaa cggtcgccgt
    78421 aatatgactt ctttggattt cgctgaaatc acaacaagca ctcctgaaaa atcattgctt
    78481 gttgcattga agagcaaggc tggtcgtaac aacaacggtc gtatcacagt tcgtcaccaa
    78541 ggtggtggac acaaacgttt ctaccgtttg gttgacttca aacgtaacaa agacaacgtt
    78601 gaagcagttg ttaaaacaat cgagtacgat ccaaaccgtt ctgcaaacat cgctcttgta
    78661 cactacactg atggtgtgaa agcatacatc atcgctccaa aaggtcttga agtaggtcaa
    78721 cgtatcgttt caggtccaga agcagatatc aaagtcggaa acgctcttcc acttgctaac
    78781 atcccagttg gtactttgat tcacaacatc gagttgaaac caggtcgtgg tggtgaattg
    78841 gtacgtgctg ctggtgcctc tgctcaagta ttgggttctg aaggtaaata cgttcttgtt
    78901 cgtcttcaat caggtgaagt tcgtatgatt cttggaactt gccgtgctac agttggtgtt
    78961 gtcggaaacg aacaacatgg acttgtaaac cttggtaaag caggacgtag ccgttggaaa
    79021 ggtatccgcc caacagttcg tggttctgta atgaacccta acgatcaccc acacggtggt
    79081 ggtgaaggta aagcaccagt tggtcgtaaa gcaccatcta ctccatgggg caaacctgct
    79141 cttggtctta aaactcgtaa caagaaagcg aaatctgaca aacttatcgt tcgtcgtcgc
    79201 aacgagaaat aatattaaac tagtcgctta agcaactagt aaatccgcca gctcggtagt
    79261 gctccatagg agcgcaagcc gctgtggtac aacatttaaa ggagaaaata taaaaatggg
    79321 acgcagtctt aaaaaaggac ctttcgtcga tgagcatttg atgaaaaaag ttgaagctca
    79381 agctaacgac gaaaagaaaa aagttattaa aacttggtca cgtcgttcaa cgatcttccc
    79441 aagtttcatt ggttacacta ttgcagttta tgacggacgt aaacacgtac ctgtttacat
    79501 ccaagaagac atggtaggcc acaaacttgg tgaatttgca ccaactcgta cttacaaagg
    79561 tcacgctgca gacgacaaga aaacacgtag aaaataagga gaacataaat ggcagaaatt
    79621 acttcagcta aagcaatggc tcgtacagta cgtgtttcac ctcgtaaatc acgtcttgtt
    79681 cttgataaca tccgtggtaa aagcgtagcc gatgcaatcg caatcttgac attcactcca
    79741 aacaaagctg ctgaaatcat cttgaaagtt ttgaactcag ctgtagctaa cgctgaaaac
    79801 aactttggtt tggataaagc taacttggta gtatctgaag cattcgcaaa cgaaggacca
    79861 actatgaaac gtttccgtcc acgtgcgaaa ggttcagctt caccaatcaa caaacgtaca
    79921 gctcacatca ctgtagctgt tgcagaaaaa taaggaggta aaatcgtggg tcaaaaagta
    79981 catccaattg gtatgcgtgt cggcatcatc cgtgattggg atgccaaatg gtatgctgaa
    80041 aaagaatacg cggattacct tcatgaagat cttgcaatcc gtaaattcgt tcaaaaagaa
    80101 cttgctgacg cagcagtttc aactattgaa atcgaacgcg cagtaaacaa agttaacgtt
    80161 tcacttcaca ctgctaaacc aggtatggtt atcggtaaag gtggtgctaa cgttgatgca
    80221 ctacgtgcaa aacttaacaa attgactgga aaacaagtac acatcaacat catcgaaatc
    80281 aaacaacctg atttggatgc tcaccttgta ggtgaaggaa ttgctcgtca attggagcaa
    80341 cgtgttgctt tccgtcgtgc acaaaaacaa gcaatccaac gtgcaatgcg tgctggagct
    80401 aaaggaatca aaactcaagt atcaggtcgt ttgaacggtg cagatatcgc ccgtgctgaa
    80461 ggatactctg aaggaactgt tccgcttcac acacttcgtg cagatatcga ttacgcttgg
    80521 gaagaagcag atactacata cggtaaactt ggtgttaaag tatggatcta ccgtggtgaa
    80581 gttcttccag ctcgtaaaaa cactaaagga ggtaaataac caatgttagt acctaaacgt
    80641 gttaaacacc gtcgtgaatt ccgtggaaaa atgcgcggtg aagcaaaagg tggaaaagaa
    80701 gtagcattcg gtgaatacgg tcttcaagct acaactagcc actggatcac taaccgccaa
    80761 atcgaagctg ctcgtatcgc catgactcgt tacatgaaac gtggtggtaa agtttggatt
    80821 aaaatcttcc cacacaaatc atacactgct aaagctatcg gtgtgcgtat gggatctggt
    80881 aaaggggcac ctgaaggttg ggtagcacca gttaaacgtg gtaaagtgat gttcgaaatc
    80941 gctggtgtat ctgaagagat tgcacgtgaa gcgcttcgac ttgctagcca caaattgcca
    81001 gttaaatgta aattcgtaaa acgtgaagca gaataaggag aaggcatgaa acttaatgaa
    81061 gtaaaagaat ttgttaaaga acttcgtggt ctttctcaag aagaactcgc gaagcgcgaa
    81121 aacgaattga aaaaagaatt gtttgaactt cgtttccaag ctgctactgg tcaattggaa
    81181 caaacagctc gcttgaaaga agttaaaaaa caaatcgctc gtatcaaaac agttcaatct
    81241 gaagcgaaat aatagactag ggaaggagaa atttcaatgg aacgcaataa tcgtaaagtt
    81301 cttgttggac gtgttgtatc tgacaaaatg gacaagacaa tcacagttgt agttgaaaca
    81361 aaacgtaacc acccagtcta tggtaaacgt attaactact ctaaaaaata caaagctcat
    81421 gatgaaaaca atgttgccaa agaaggtgat atcgtacgta tcatggaaac tcgcccgctt
    81481 tcagctacaa aacgtttccg tcttgtagaa gttgttgaag aagcggtcat catctaatca
    81541 aacctgaaag gagaaaactg aaatgattca aacagaaact cgtttgaaag tcgcagacaa
    81601 cagcggtgct cgcgaaatct tgactatcaa agttcttggt ggttcaggac gtaaatttgc
    81661 aaacatcggt gatgttatcg tggcatctgt aaaacaagct actcctggtg gtgcggttaa
    81721 aaaaggtgac gttgttaaag cagttatcgt tcgtactaaa tcaggtgctc gtcgtgctga
    81781 tggttcatac atcaaatttg acgaaaacgc agcagttatc atccgtgaag acaaaactcc
    81841 tcgcggaaca cgtatctttg gcccagttgc acgtgaattg cgtgaaggtg gtttcatgaa
    81901 gatcgtgtca cttgctccag aagtacttta atttttagga acaaactagt cccctagctt
    81961 caagctaggg tgcccttatg ggcgtaagaa aaatcaagga gaaacctaat gtttgtaaaa
    82021 aaaggcgaca aagttcgcgt aatcgctggt aaagataagg gaacagaagc tgttgtcctt
    82081 actgcccttc caaaagtaaa caaagttatc gttgaaggtg ttaacattgt taagaaacac
    82141 caacgtccaa ctaacgagct tcctcaaggt ggtatcatcg agaaagaagc agctatccac
    82201 gtatcaaatg ttcaagtttt ggacaaaaat ggtgtagctg gtcgtgttgg ttacaaattt
    82261 gtagacggta aaaaagttcg ctacaacaaa aaatcaggcg aagtgcttga ttaatcacga
    82321 aggaaaggag aagtataatg gcaaatcgtt taaaagaaaa atatcttaat gaagtagttc
    82381 ctgctttgac agaacaattc aactactcat cagtgatggc tgtgcctaaa gtagataaga
    82441 ttgttttgaa catgggtgtt ggtgaagctg tatcaaacgc taaaagcctt gaaaaagctg
    82501 ctgaagaatt ggcacttatc tcaggtcaaa aaccacttat cactaaagct aaaaaatcaa
    82561 tcgccggctt ccgtcttcgt gaaggtgttg cgatcggtgc aaaagttacc cttcgtggtg
    82621 aacgtatgta cgaattcttg gataaattgg tatcagtttc acttccacgt gtacgtgact
    82681 tccacggtgt cccaacaaaa tcatttgatg gacgcgggaa ctacacactt ggtgtgaaag
    82741 aacaattaat cttcccagaa atcaacttcg atgacgttga caaaactcgt ggtcttgaca
    82801 tcgttatcgt aacaactgct aacactgacg aagagtcacg tgcattgctt acaggccttg
    82861 gaatgccttt tgcaaaataa tataggaggt aaatctaatg gctaaaaaat caatggtagc
    82921 tagagaggct aaacgccaaa aaattgttga ccgttatgct gaaaaacgtg ctgcattaaa
    82981 ggcggcaggg gactacgaag gtttatctaa attacctcgc aacgcctcac cgactcgttt
    83041 acataatcgt tgtagagtta cggggcgccc acattcagtt taccgcaaat ttggtctgag
    83101 tcgtatcgct tttcgcgaac ttgcgcataa aggtcaaatt cctggtgtaa caaaagcatc
    83161 ttggtaattt aagatatcaa gggtgtcaaa actccaagta aaaataggaa acttgacgaa
    83221 gaaactaaag tttctaggaa agtttatctt tttcacacag agtttagccc gggttcaatt
    83281 gggcttgcca atttgaaccc gagctacagc tttggcaaaa aagaccaatt tgctttggag
    83341 cattgcttct gcattaaatt gtctattttt gctcgtgctg ttacgctctt tgtatcatgt
    83401 attaactagc aagtgcaact tgcaaactac tagtaagagg agaaaaacaa aatggttatg
    83461 actgacccaa tcgcagactt cctaactcgt attcgtaatg ctaaccaagc taaacacgaa
    83521 gtacttgaag tacctgcatc aaacatcaaa aaagggattg ctgaaatcct taaacgcgaa
    83581 ggttttgtaa aaaacgttga aatcatcgaa gatgacaaac aaggcgtcat ccgtgtattt
    83641 cttaaatacg gaccaaatgg tgaaaaagtt atcactaact tgaaacgtgt ttctaaacca
    83701 ggacttcgtg tctacaaaaa acgtgaagac cttccaaaag ttcttaacgg acttggaatt
    83761 gccatccttt caacttctga aggtttgctt actgataaag aagcacgcca aaagaatgtt
    83821 ggtggtgagg ttatcgctta cgtttggtaa aatcaagata caaagctcgt aaagaacaaa
    83881 gcaaaattag gaagttggag aagtttgttt acaaacaagc caacttatct attttgcaca
    83941 gttcttagag cgtgttcagt tcagctcttg aactaaataa gtatctgaac cccgtgaaaa
    84001 ctggccgttc tggcctgaca atttaacagg agaaaataaa catgtcacgt attggtaata
    84061 aagttatcgt gttgcctgct ggtgttgaac tcgctaacaa tgacaacgtt gtaactgtaa
    84121 aaggacctaa aggagaactt actcgtgagt tctcaaaaga tattgaaatc cgtgtggaag
    84181 gtactgaagt aactcttcac cgtccaaacg attcaaaaga aatgaaaact atccacggaa
    84241 ctactcgtgc ccttttgaac aacatggttg ttggtgtatc agaaggattc aagaaagaac
    84301 ttgaaatgcg tggggttggt taccgtgcac agcttcaagg atctaaactt gttttggctg
    84361 ttggtaaatc tcatccagac gaagttgaag ctccagaagg aattactttt gaacttccaa
    84421 acccaacaac aatcgttgtt agcggaattt caaaagaagt agttggtcaa acagctgctt
    84481 acgtacgtag ccttcgttca ccagaaccat ataaaggtaa aggtatccgt tacattggtg
    84541 aattcgttcg ccgtaaagaa ggtaaaacag gtaaataatg ttgagtggtt gatcatcaac
    84601 caccaaccta ttttccaact ttgtgcatag cacacgattt aaaactaaag aggtgaaaac
    84661 tgtgatttca aaaccagata aaaacaaact ccgccaaaaa cgccaccgtc gcgttcgcgg
    84721 aaaactctct ggaactgctg atcgcccacg tttgaacgta ttccgttcta atacaggcat
    84781 ctacgctcaa gtgattgatg acgtagcggg tgtaacgctc gcaagtgctt caactcttga
    84841 taaagaagtt tcaaaaggaa ctaaaactga acaagccgtt gctgtcggta aactcgttgc
    84901 agaacgtgca aacgctaaag gtatttcaga agtggtgttc gaccgcggtg gatatctata
    84961 tcacggacgt gtgaaagctt tggctgatgc agctcgtgaa aacggattga aattctaata
    85021 ggaggacact agaaaatggc atttaaagac aatgcagttg aattagaaga acgcgtagtt
    85081 gctgtcaacc gtgttacaaa agttgttaaa ggtggacgtc gtcttcgttt cgcagctctt
    85141 gttgttgttg gtgaccacaa tggtcgcgta ggatttggta ctggtaaagc tcaagaagtt
    85201 ccagaagcaa tccgtaaagc agtagatgat gctaagaaaa acttgatcga agttcctatg
    85261 gttggaacaa caatcccaca cgaagttctt tcagaattcg gtggagctaa agtattgttg
    85321 aaacctgctg tagaaggttc tggagttgcc gctggtggtg cagttcgtgc cgttgtggaa
    85381 ttggcaggtg tggcagatat tacatctaaa tcacttggtt ctaacactcc aatcaacatt
    85441 gttcgtgcaa ctgttgaagg tttgaaacaa ttgaaacgcg ctgaagaaat tgctgccctt
    85501 cgtggtattt cagtttctga tttggcataa gaaaggggat aaaatggctc aaattaaaat
    85561 tactttgact aagtctccaa tcggacgcat tccatcacaa cgtaaaactg ttgtagcact
    85621 tggacttggc aaattgaaca gctctgttat taaagaagat aacgctgcta tccgtggtat
    85681 gatcacagca gtatctcact tagtaacagt tgaagaagta aactaatgaa gttttagggg
    85741 atgtgcactg taccatcccc taaaactaga tatagtcatc tatgatgaca tcgtataggc
    85801 gagttgatgg gggagacaac cttttctccc ttatcggcgc tagcatttta caaaagagga
    85861 gaaaataaaa atgaaacttc atgaattgaa acctgcagaa ggttctcgta aagtacgtaa
    85921 ccgcgttggt cgtggtactt catcaggtaa cggtaaaaca tctggtcgtg gtcaaaaagg
    85981 tcaaaaagct cgtagcggtg gcggagttcg ccttggtttt gaaggtggac aaactccatt
    86041 gttccgtcgt cttccaaaac gtggattcac taacatcaac gctaaagaat acgcaattgt
    86101 gaaccttgac caattgaacg tctttgaaga tggtgctgaa gtaactccag ttgttcttat
    86161 cgaagcagga attgttaaag ctgaaaagtc aggtattaaa attcttggta acggtgagtt
    86221 gactaagaaa ttgactgtga aagcagctaa attctctaaa tcagctgaag aagctatcac
    86281 tgctaaaggt ggttcagtag aagtcatcta agagaggtga cctatgtttt ttaaattatt
    86341 aagagaagct cttaaagtca agcaggttcg atcaaaaatt ttatttacaa tttttatcgt
    86401 tttggtcttt cgtatcggaa ctagcattac agttcctggt gtgaatgcca atagcttgaa
    86461 tgctttaagt ggattatcct tcttaaacat gttgagcttg gtgtcgggga atgccctaaa
    86521 aaacttttcg atttttgccc taggagttag tccctatatc accgcttcta ttgttgtcca
    86581 actcttgcaa atggatattt tacccaagtt tgtagagtgg ggtaaacaag gggaagtagg
    86641 tcgaagaaaa ttgaatcaag ctactcgtta tattgctcta gttctcgctt ttgtgcaatc
    86701 tatcgggatt acagctggtt ttaatacctt ggctggagct caattgatta aaactgcttt
    86761 aactccacaa gtttttctga cgattggtat catcttaaca gctggtagta tgattgtcac
    86821 ttggttgggt gagcaaatta cagataaggg atacggaaac ggtgtttcca tgattatctt
    86881 tgccgggatt gtttcctcaa ttccagagat gattcagggc atctatgtgg actactttgt
    86941 gaacgtccca agtagccgta tcacttcatc tatcattttc gtaatcattt tgattattac
    87001 tgtattgttg attatttact ttacaactta tgttcaacaa gcagaataca aaattccaat
    87061 ccaatatact aaggttgcac aaggtgctcc atctagctct taccttccgt taaaggtaaa
    87121 tcctgctgga gttatccctg ttatctttgc cagttcgatt actgcagcgc ctgcggctat
    87181 tcttcagttt ttgagtgcca caggtcatga ttgggcttgg gtaagggtag cacaagagat
    87241 gttggcaact acttctccaa ctggtattgc catgtatgct ttgttgatta ttctctttac
    87301 attcttctat acgtttgtac agattaatcc tgaaaaagca gcagagagcc tacaaaagag
    87361 tggtgcctat atccatggag ttcgtcctgg taaaggtaca gaagaatata tgtctaaact
    87421 tcttcgtcgt cttgcaactg ttggttccct cttccttggt gtgatttcca ttttaccgat
    87481 tgcagctaaa gatgtatttg gtctttctga tgttgttgcc tttggtggaa caagtctctt
    87541 gatcattatc tctacaggta tcgaaggaat caagcaattg gaaggttacc tattgaaacg
    87601 taagtatgtt ggtttcatgg acagaacaga ataaaagtat ttactgaatc agtaaatgct
    87661 gagggagtgg aggtttaaac tctgacattt gtaagagttg gatctcccct cttctatttt
    87721 gtttttaaat aggggtgaaa agactttttg cttctattta aaaataaaat aaggagatca
    87781 aatcatgaat cttttgatta tgggcttacc tggtgcaggt aagggaactc aagcagcaaa
    87841 aatcgtagaa caattccatg ttgcacatat ctcaacaggt gatatgttcc gcgctgcaat
    87901 ggtaaatcaa actgaaatgg gtgttcttgc taagtcatat attgacaagg gtgaattggt
    87961 tcctgacgaa gttacaaatg gaatcgtaaa agaacgtctt tcacaagatg atattaaaga
    88021 aacaggattc ttattggatg gttacccacg tacaattgaa caagctcatg ccttggacaa
    88081 aacattggct gaacttggca ttgaactaga aggtgttatc aatattgaag tgaaccctga
    88141 cagcctcttg gaacgtttga gtggccgtat catccaccgc gtaactggag aaactttcca
    88201 caaggtcttt aacccaccag ttgactataa agaagaagat tactaccaac gtgaagatga
    88261 taagcctgag acagtaaaac gtcgtttgga tgttaatatt gctcaaggag aaccaatcat
    88321 tgctcactac cgtgccaaag gtttggttca tgacatcgaa ggtaatcaag atatcaatga
    88381 tgtcttctca gatattgaaa aagtattgac aaatttgaaa taaagcgttt ttcacacttg
    88441 caaaaatccg ctacaaatgt tatactgaga tagtctgact tataattgtt gtctctgtgt
    88501 ctagaggcat cgaatcgaaa tttatggagg tgcttttgcg tggcaaaaga cgatgtgatt
    88561 gaagttgaag gcaaagtagt tgatacaatg ccgaatgcaa tgtttacggt tgaacttgaa
    88621 aatggacatc agattttagc aacagtttct ggtaaaattc gtaaaaacta tattcgtatt
    88681 ttagcgggag atcgtgttac tgtcgaaatg agtccatatg acttgacacg tggacgtatc
    88741 acttaccgct ttaaataatc gaaaaacttg gagggataag aaatgaaagt aagaccatcg
    88801 gtcaaaccaa tttgcgaata ctgtaaagtt attcgtcgta atggtcgtgt tatggtaatt
    88861 tgcccagcaa atccaaaaca caaacaacgt caaggataag atagaaagga gaaaacatgg
    88921 ctcgtattgc tggagttgat attccaaatg acaaacgcgt agtaatctca ttgacttatg
    88981 tttatggtat cggacttgca acatctaaga aaattttggc tgctgctgga atctcagaag
    89041 atgttcgtgt acgtgatctt acatcagatc aagaagatgc tatccgtcgt gaagtggatg
    89101 caatcaaagt tgaaggtgac cttcgtcgtg aagtaaactt gaacatcaaa cgtttgatgg
    89161 aaatcggttc ataccgtggt atccgtcacc gtcgtggact tcctgtccgt ggacaaaata
    89221 ctaaaaacaa cgctcgcact cgtaaaggta aagctgttgc gattgctggt aagaaaaaat
    89281 aatataggag gtaaaagtct tggctaaacc aacacgtaaa cgtcgtgtga aaaagaatat
    89341 cgaatctggt attgctcata ttcacgctac atttaataac actattgtta tgattactga
    89401 tgtgcatggt aatgcaattg cttggtcatc agctggtgct cttggtttca aaggttctcg
    89461 taaatctaca ccattcgctg ctcaaatggc ttctgaagct gctgctaaat ctgcacaaga
    89521 acacggtctt aaatcagttg aagttactgt aaaaggtcca ggttctggtc gtgagtcagc
    89581 tattcgtgcg cttgctgccg ctggtcttga agtaacagca attcgtgatg tgactccagt
    89641 gccacacaat ggtgctcgtc ctccaaaacg tcgccgtgta taatcatcgc attacactgc
    89701 ttttcgttta agagggagta actaaatgat cgagtttgaa aaaccaaata taacaaaaat
    89761 tgatgaaaat aaagattatg gcaagtttgt aatcgaacca cttgaacgtg gctacggtac
    89821 aactcttggt aactctcttc gtcgtgtact tctagcttct ctaccaggag cagctgtgac
    89881 atctatcaac attgatggtg tgttacatga gtttgacaca gttccaggtg ttcgtgaaga
    89941 cgtgatgcaa atcattctga acattaaagg aattgcagtg aaatcgtacg ttgaagacga
    90001 aaaaatcatc gaactggatg ttgaaggtcc tgctgaagta acagctggtg acattttgac
    90061 agatagcgat attgaaattg taaatccaga tcattatctc tttacaatcg gtgaaggttc
    90121 ttctctaaaa gcgactatga ctgttaacag tggtcgtgga tatgtacctg ctgatgaaaa
    90181 taaaaaggat aatgcaccag ttggaacact tgctgtagat tctatttata caccagttac
    90241 aaaagtcaac tatcaagtgg aacctgctcg tgtaggtagc aatgatggtt tcgacaaatt
    90301 aacccttgaa atcttgacaa atggaacaat tattccagaa gatgctttag ggctttcagc
    90361 acgtattttg acagaacatc ttgatttgtt tacaaatctt actgagattg ctaagtcaac
    90421 tgaagtgatg aaagaagctg atactgaatc tgacgaccgt attttagatc gtacgattga
    90481 ggaactggac ttgtctgtgc gttcatacaa ctgtttaaaa cgtgccggta tcaatactgt
    90541 gcatgatttg acagaaaaat ctgaagcaga gatgatgaaa gtacgaaatc ttggacgcaa
    90601 gagtttggaa gaagtgaaac tcaaactcat tgatttgggt cttggattaa aagataaata
    90661 aaggaggaat acatggctta ccgtaaacta ggacgcacta gctcacaacg taaagcaatg
    90721 cttcgcgatt tgacaactga ccttttgatc aacgaatcaa tcgtgacaac tgaagctcgt
    90781 gctaaagaaa tccgtaaaac tgttgaaaaa atgattactc taggtaaacg tggtgatttg
    90841 catgcacgtc gtcaagcagc tgctttcgta cgtaatgaaa tcgcatctga aaactatgat
    90901 gaagcaactg ataagtacac ttctactaca gcacttcaaa aattgttctc agaaatcgca
    90961 cctcgttatg ctgaacgtaa cggtggatac actcgtatcc ttaaaactga accacgtcgt
    91021 ggtgatgcag cgccaatggc gatcatcgaa ttagtataaa atcatcaatt ttgttgagtg
    91081 ttatgatgat ggagtcttgt gctcttagtc tagctctggt ctaccgctag gatttcggtc
    91141 ctagcgggaa cactcatcat aagttgggat agtagacgct tgtttacgaa attgtttttt
    91201 tcttaagaac aacttcgtaa gcaggcgttt ttgagtattt tcgttagaat tatgctatac
    91261 tatttgaaaa gaatcctgtt taatgttaag gtttcttatt ttaagaagaa ttggagttta
    91321 cttatgaaag ccattataac tgttgttggt aaagataaat ctggaattgt tgcaggtgtt
    91381 tctggtaaaa ttgcagaatt aggattgaat attgacgata tctctcaaac tgtcttggat
    91441 gaatatttta cgatgatggc tgttgtatct agtgatgaaa agcaagattt tacctatctt
    91501 cgtaatgaat ttgaagcttt tgggcaaact ttgaatgtaa aaatcaatat tcagagtgca
    91561 gcgattttcg aagctatgta taatatctag gaggttatca tggatattag acaagttact
    91621 gaaaccatcg ccatgattga ggagcaaaac ttcgatatta gaaccattac catggggatt
    91681 tctcttttgg actgtatcga tccagatatc aatcgtgctg cggagaaaat ctatcaaaaa
    91741 attacgacaa aggcggctaa tttagtagct gttggtgatg aaattgcggc tgagttggga
    91801 attcctatcg ttaataagcg tgtatcggtg acacctattt ctctgattgg ggcagcgaca
    91861 gatgcgacgg actacgtggt tctggcaaaa gcgcttgata aggctgcgaa agagattggt
    91921 gtggacttta ttggtggttt ttctgcctta gtacaaaaag gttatcaaaa gggagatgag
    91981 attctcatca attccattcc tcgcgctttg actgagacgg ataaggtctg ctcgtcagtc
    92041 aatatcggct caaccaagtc tggtattaat atgacggctg tggcagatat gggacgaatt
    92101 atcaaggaaa cggcaaatct ttcagatatg ggagcggcca agttggttgt attcgctaat
    92161 gctgttgagg acaatccatt tatggcgggt gcctttcatg gtgttgggga agcagatgtt
    92221 atcatcaatg tcggagtttc tggtcctggt gtggtgaaac gtgctttgga aaaagttcgt
    92281 ggacagagct ttgatgtagt agccgaaaca gttaagaaaa ctgcctttaa aatcactcgt
    92341 atcggtcaat tggttggtca aatggccagt gagagactgg gtgtggagtt tggtattgtg
    92401 gacttgagtt tggcaccaac ccctgcggtt ggagactctg tggcacgtgt ccttgaggaa
    92461 atggggctag aaacagttgg cacgcatgga acgacagctg ccttggccct cttgaacgac
    92521 caagttaaaa agggtggagt gatggcctgt aaccaggtcg gtggtctatc tggtgccttt
    92581 atccctgttt ctgaggatga aggaatgatt gctgcagtgc aaaatggctc tcttaattta
    92641 gaaaaactag aagctatgac ggctatctgt tctgttggat tggatatgat tgccatccca
    92701 gaagatacgc ctgctgaaac tattgcggct atgattgcgg atgaagcagc aatcggtgtt
    92761 atcaacatga aaacaacagc tgttcgtatc attcccaaag gaagagaagg cgatatgatt
    92821 gagtttggtg gtctattagg aactgcaccc gttatgaagg ttaatggggc ttcgtctgtc
    92881 gacttcatct ctcgcggtgg acaaatccca gcaccaattc atagttttaa aaattaagaa
    92941 aataggagaa attttaagtt ctatttaaga ttagatgtgt atactataat cattaaataa
    93001 agacctccta atattatttg aaacagataa cactgaatta gtttgaattt gattttcatc
    93061 taatatcttt atttaatgaa ctcctaaact ttttcataat aatctccttc aaaagtcgcc
    93121 tgtatgggtg gcttttattt tatcattcat gatataatag aagcaaacgg aggacggaaa
    93181 atggtaaaag tacgattgta tttggtacgt catggcaaga ccatgtttaa cacgattggt
    93241 cgcgcgcaag gttggagcga tactccctta actgctgaag gtgaacgagg gattcaagag
    93301 ttaggaactg gtttgcgaga atctgatcta cagtttgagc gcgcttattc gagtgattct
    93361 ggtcgtacca ttcagaccat gggaattatc cttgaagaac ttggcttgca ggggaaaatc
    93421 ccttatcgca tggacaagcg tatcagagaa tggtgtttcg gtagttttga tggagcctat
    93481 gatggcgatc ttttcatggg cattattcct cgtatcttta atgtggacca cgttcaccaa
    93541 ttgtcttatg ctgaactggc tgagggcttg gtagaggtcg atacagctgg ttgggctgaa
    93601 ggctgggaaa aactcagtgg ccgaatcaag gaaggctttg aaatgattgc aaaagaaatg
    93661 gaagatcaag gtggaggtaa cgcccttgtt gtcagccatg gaatgactat tggaaccatt
    93721 gtttatctga ttaatggcat gcatccgcat ggtctagata atggtagcgt gacgattctt
    93781 gaatatgagg acggtcagtt tagggttgaa gttgtcggtg accgtagtta ccgagagcta
    93841 ggacgtgaga agatggaaga aggctctatt taatcagtct agacttgctt gccatgagct
    93901 agggatttga taagaatatc aagataagaa aaaacagccg agggtactcc tttcggctgt
    93961 ttttgatgtg gaaaactaaa gtgtaatgct attgctttta gagattttca taaacaagag
    94021 caaggaacct actgttagaa cagtcaggat agttgacaag gctgcggcta caccgtaatt
    94081 tcctctgaga acctctgtat aaatagctac agtcattgtt cttgttttga cattgtagag
    94141 gaggatagaa gtagagagtt ttgaaatcat tgtgacccaa gataagatgg ctccagaaat
    94201 gataccagat agcatcattg gagttgtaat cttagcaaag gtattgagac gactacttcc
    94261 taagctttca gcagcttctt caatacttgg tgctatttgt tgtaagctag caacagatga
    94321 gcgaatagta taaggtaatc ttctgacaga tagagacata atcaagatga aagcagtccc
    94381 tgtaatcata agaaatccac ttccaaatag accagagaaa tgaaggcaat ccctagaacg
    94441 gttcctggta caatataagg taccatactg aggctgtcaa ttaagtttgt aaacaaattc
    94501 cgttttctaa cggctaggta ggagataaat gtcgcaaata gaacaactag aactaaggca
    94561 atcaaaggga tacgaatggt attgaaaata gcagatccca tacgattgaa agctaccttg
    94621 taactgtttg gagaataacc tttaacaaat accatacctg atgtttttag gaaagaggta
    94681 taaattaagt agatttgagg taaaacagag ataaagataa ttccgtagac tgttgcataa
    94741 atggcagcca tttttccttt tgtagttttt ttaggctcaa ttggatggat cagattcatg
    94801 ctgaaactgt agcggtttgc aatgtgtttt tggataagga aaattgccaa ggcaatgata
    94861 atcgccataa ttgcaaaagc agaatttcct ccaacctcgc taataaattg ggtataaatc
    94921 aggacaggga aagtccgata tccttcgcca atcaacatag gcgttccaaa gtctgagaat
    94981 gctctcataa atacaagcaa ggagctgcta gtaaggttgg aactaggaga ggtaaaacaa
    95041 ccgttacgat aggtttaaat ccgaaggacc ccatgctttc agctgcttca agtagagaat
    95101 tgtcaatact gttcattgtt ccagcaacat atagaaatac cagtgggaat agttgcagtg
    95161 taaagacaag tacaattcct ttgaatccat aaatatcgat agctggaaga tgaagggcat
    95221 ttgtcaaaaa tttagtgatg acctcatttc gtcccagcaa gagaatccag gagtaggctc
    95281 ctacgaaagg agctgacatg gaagcaatga taatcaatat ttgtagaaat ttcttcccct
    95341 tgaagtcata catagagaag agataagcta atagggttcc tacaactaag gaagtgatag
    95401 tagcggtaat ggaaaccttg aaactgttga ctagtgtctc agagtagtag gctttactaa
    95461 agaaagtgac aaaattagct agtgagaatt gtccttcatg tataagtgct tgcttgagca
    95521 cggtaacgat aggataaacg agaaagatag gataggtaag aaagaggaag aaagaggaag
    95581 ctgtccaaat atttagtttt ttacgttcca tggttgactc cttttatcag gttttgggaa
    95641 ccatctgcag aaaagatgtt taatttttgc gtattgattc gtagacgaat acgattgcct
    95701 ttttgtagat cttcttcaaa agttgattct tcactaactt gaatttttga ggcaaaacct
    95761 gtctcaatga aataatccgt atttagtcca agatagacgc tatctctaat agttccttca
    95821 atatctccag attcatcttt gataaactct tcgggacgaa tgcttacatg aatagcttgc
    95881 tcctcaacct gatcaagagc tggcattcga agggcatagc catctgaaaa gacgatataa
    95941 gcgccgtcgc tccgtttttc aagattggca gggataatat ttgtgcgtcc gataaaggtt
    96001 gccacaaact cattagctgg tttatgatag agttcttttg gtcggccgat ttgttggatc
    96061 accccatctt tcataacagc aatttggtct gaaatagcca tggcttcttc ttggtcgtgg
    96121 gttacataaa cagttgtaat tcccacttcg tgttggattt ctcggatggc ttgacgcata
    96181 tccaagcgaa gtttggcctc cagattacta agtggctcgt ccatgaggag aacacttgga
    96241 ttaaccgcta aggcgcatgc caaggtgaca cgttgttgtt gtccaccact gagtttatcg
    96301 ggctttcaat ccgcatattg agcaatttgc atgagttcaa gatacttgtt ggtctgttga
    96361 atcaattctt cttttggaac cttcttttgc ataagaccaa aagcaacgtt gtctcggaca
    96421 gtcaaatgtg ggaaaatagc gtagttttgg aaaaccatcc cgatattgcg tttgctgggt
    96481 tccatattat tgatttttgt atcatcgaag taaaattctc catctttgat actgttgaaa
    96541 cctgcaatca tacgaagaag ggtcgttttc ccacatcctg aagctccaag aagggtaaag
    96601 agacttcctt ttggaattgt aatgttcaaa ttctcaataa cagggacatc gtggtagatt
    96661 tttttggcgt taataatttc gatctcattc atagtgaacc tcttttactg tttagattgg
    96721 atatctgtaa agacttcgtt gtatttctta acgatatctg atttattctt gatgacataa
    96781 tcataatctt cagtgagtgt tttgattttg tcaattggtt tcatgttttc gcttgtttta
    96841 gcatttttac gaacaggacg gttagtagtg gttgtaccaa gtgtatcttg tacttcttga
    96901 gagataataa aatcgataaa tttcttggca ttttccatat ttttagcttt tttaacgata
    96961 gcagcactag caggtaggaa gacggttcct tcttttggat agactacctt aatgttagct
    97021 ccgtcattta agagtttaac tgctggatct tcataagaga gaccaacagc catttctcca
    97081 tcagcgactg ctttatagac accagatgaa cttaaaccga ttttatagta t
//
LOCUS       DAVHSO010000002        76073 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.002, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000002 DAVHSO010000000
VERSION     DAVHSO010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 76073)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 76073)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..76073
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.002"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..246)
                     /locus_tag="VVR18_000116"
     CDS             complement(<1..246)
                     /locus_tag="VVR18_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6031723.1"
                     /translation="MNYLKFIKKTKLILMGILIFLSSFNGVLLSGIIVYAGSLNQTSS
                     FSDVLRFGAISILGWSAIYISNYYLEVTEASITKDINV"
     gene            complement(243..2183)
                     /locus_tag="VVR18_000117"
     CDS             complement(243..2183)
                     /locus_tag="VVR18_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HEU6031724.1"
                     /translation="MNQSNEIFLNTIQEKTHYKRSISSSFQELKKWNSLIFRRGRYWY
                     QFDNWSIPNTGVIKEWYVEDNDWIPKVSSSSLDNSNSLKIVFDVEKYTLPDDSILQDV
                     RISSDESYIVLVVSSLRSTNLIGIKKYTMEELFIIEDISVESSFYLGKFGVMYTRSKE
                     YGRPSKLFYKSFDSFTEEELFEENECSFRLKIVHIDSNNCFVKSVDFQKGRIFLYSFD
                     RTGFVRHSYTETVAPTPRDIALFSTEKAQYFLGLSSTEEKKDQLILRETSSGDRVSIT
                     IPYQDRARRVHCIGRYILLDCSNAANSVFYLATFKNNSLRELSVNKITFDEKTTLYEN
                     SFSDRVLLFLERRTFYEKILSFDLIENTLKTEFERPIIKSNNTKYFSKVIWTKKDSYD
                     VSIPISLFWKSEDTDELPRRKKCILSVYGAYGKNDNSDLDEIMLSIIDAGFIYAIVHV
                     RGGGYLGGEWYRSGKALNKWNSIRDFIEGVNYLRENDVIDSKRLGLITSSAGGIIAGA
                     VLNEEKNLLQSILLFSPFINPYDTLQNPNDPLSKTEIAEWGDIRDPEVKAYIKSYSPM
                     QNIEKARDSNTVIVNILGEKDPYINNNEVIEWSKKLNSIGVKSLLYLNKAAGHGGFTP
                     SDVLLMIDTLNYFFEEVGRNNL"
     gene            complement(2216..4713)
                     /locus_tag="VVR18_000118"
                     /pseudo
     CDS             complement(2216..4713)
                     /locus_tag="VVR18_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808684.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="protein kinase/lanthionine synthetase C family
                     protein"
     gene            complement(5003..5140)
                     /locus_tag="VVR18_000119"
     CDS             complement(5003..5140)
                     /locus_tag="VVR18_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="HEU6031725.1"
                     /translation="MAEEVLNLQLVSVQVDETDKVDGMRFSTFSTNRCGNWSAFSWEN
                     C"
     gene            complement(5342..5929)
                     /locus_tag="VVR18_000120"
     CDS             complement(5342..5929)
                     /locus_tag="VVR18_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6031726.1"
                     /translation="MKRIIPVYIFQQVNVLLVSLYLLKFLCIGELTILQILYGSSLIS
                     FLWMYGQRKQAHKVNMKSRMKWLGIGFVSLLIISLCFSLIHAQESTNQANLIGLQHQV
                     PWFSFLLFLINASMVEEFLYREILWNLVRKLDIRVALTSVLFALAHHPGTIIAWCLYV
                     SLGMFLGLVRYKLDLWGSMGLHLVWSLLVYSLLLF"
     gene            complement(6022..6165)
                     /locus_tag="VVR18_000121"
     CDS             complement(6022..6165)
                     /locus_tag="VVR18_000121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031727.1"
                     /translation="MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQK
                     IRH"
     gene            complement(6178..6558)
                     /locus_tag="VVR18_000122"
     CDS             complement(6178..6558)
                     /locus_tag="VVR18_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEU6031728.1"
                     /translation="MIDLYLSKNSQRNQLLLDFFQNYGIEVSCHSVSEMTKDKLIEMM
                     SYSSDCFEFLSPNLLRFKNRDNLRLTDFVEIILKNPELTIRLPLVVSNKRVYPSLNLE
                     EARALLPRDTKQLIYMAQTHYLYN"
     gene            complement(6551..6874)
                     /locus_tag="VVR18_000123"
     CDS             complement(6551..6874)
                     /locus_tag="VVR18_000123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031729.1"
                     /translation="MTFLDDYHKKHNYPLFYESYLQNVMEFLESQDIKNGVDAFVDDH
                     QNLVFVLYGQGYRAEGKEGILTTQVTVKAYDEDKKPINFANLLDSLIVSEYQMEPNLW
                     EVSHD"
     gene            complement(6888..7136)
                     /locus_tag="VVR18_000124"
                     /pseudo
     CDS             complement(6888..7136)
                     /locus_tag="VVR18_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
     gene            complement(7136..7306)
                     /locus_tag="VVR18_000125"
     CDS             complement(7136..7306)
                     /locus_tag="VVR18_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031730.1"
                     /translation="MQKEGQSSRQFVKSHLMTIMGVDIVKATQLVDEMEQVGLIRFDE
                     FGNVGILVLEGQ"
     gene            complement(7505..7873)
                     /gene="rplL"
                     /locus_tag="VVR18_000126"
     CDS             complement(7505..7873)
                     /gene="rplL"
                     /locus_tag="VVR18_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HEU6031731.1"
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAA
                     DAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVAT
                     AEAEEIKAKLEEAGASVTLK"
     gene            complement(7949..8449)
                     /locus_tag="VVR18_000127"
     CDS             complement(7949..8449)
                     /locus_tag="VVR18_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HEU6031732.1"
                     /translation="MSEAIIAKKAELVDVVAGKMKAAASIVVVDARGLTVEQDTVLRR
                     ELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFSK
                     NAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAE
                     SKEDAA"
     misc_feature    complement(8488..8623)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            complement(8699..9958)
                     /locus_tag="VVR18_000128"
     CDS             complement(8699..9958)
                     /locus_tag="VVR18_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TRZ/ATZ family protein"
                     /protein_id="HEU6031733.1"
                     /translation="MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQ
                     AEQIVDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTT
                     NAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
                     ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAE
                     TKEESGIILKRYGKRPLAFLEELGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPI
                     SNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTAALLQKMKSGDASQF
                     PIETALKVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYA
                     VKSNDVDDVYIAGEQVVKQGQVLTVEL"
     gene            complement(10260..12008)
                     /locus_tag="VVR18_000129"
     CDS             complement(10260..12008)
                     /locus_tag="VVR18_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6031734.1"
                     /translation="MKRQTVNQTLKRLVVDLANHPFLLFLAFLGTIAQVGLSIYLPIL
                     IGQVIDQVLVAGSSPVFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRDLRERII
                     HKLHRLPIAFADRQGNGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQI
                     HLLMTLLVLLLTPLSMVISRFIAKRSYHLFQKQTETRGIQTQLIEESLSQQTIIQSFN
                     AQTEFIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGST
                     LTVGRLVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLT
                     SDQVKGAISFKHVSFGYHPEKILIKDLSIDIPAGSKVAIVGPTGAGKSTLINLLMRFY
                     PISSGDILLDGQSIYDYTRVSLRQQFGMVLQETWLTQGIIHDNIAFGNPEASREQVIA
                     AAKAANADFFIQQLPQGYDTKLENAGESLSVGQAQLLTIARVFLAIPKILILDEATSS
                     IDTRTEVLVQDAFAKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMDR
                     KGKYYQMQKAAAFSSE"
     gene            complement(12010..13734)
                     /locus_tag="VVR18_000130"
     CDS             complement(12010..13734)
                     /locus_tag="VVR18_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6031735.1"
                     /translation="MKHLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSL
                     PQGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGFAKELTNDLYRHILSLPKD
                     SRDRLTTSSLVTRLTSDTYQIQTGINQFLRLFLRAPIIVFGAIFMAYRISTELTFWFL
                     VMVAILTIVIVGLSRLVNPLYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQIF
                     QTLNQVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALI
                     NYLLQILVELVKLAMLINSLNQSYISAKRIEEVFVEAPEDIHSELEQKQATRDKVLQV
                     QELTFTYPDAAQPSLRYISFDMTQGQILGIIGGTGSGKSSLVQLLLGLYPVDKGNIDL
                     YQNGRSPLNLEQWRSWIAYVPQKVELFKGTIRSNLTLGLNQEVTDQELWQALEIAQAK
                     DFVSDKEGLLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESK
                     LLKAIRENFPNMSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYREIN
                     ASQHGKED"
     gene            complement(13792..14730)
                     /gene="msrB"
                     /locus_tag="VVR18_000131"
     CDS             complement(13792..14730)
                     /gene="msrB"
                     /locus_tag="VVR18_000131"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEU6031736.1"
                     /translation="MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLI
                     KETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEAD
                     LPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
                     LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPL
                     FFAKDKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPR
                     ELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK"
     gene            complement(14872..14949)
                     /locus_tag="VVR18_000132"
                     /pseudo
     CDS             complement(14872..14949)
                     /locus_tag="VVR18_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(15025..15894)
                     /locus_tag="VVR18_000133"
     CDS             complement(15025..15894)
                     /locus_tag="VVR18_000133"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000692406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HEU6031737.1"
                     /translation="MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEERDEWLIEHQI
                     GKWIPHDERNLLLKIALQIVPDLQPRRLKMTSDVPLARGLGSSSSVIVAGIELANQLG
                     QLNLSDHEKLQLATKIEGHPDNVAPAIYGNLVIASSVEGQVSAIVADFPECDFLAYIP
                     NYELRTRDSRSVLPKKLSYKEAVAASSIANVAVAALLAGDMVTAGQAIEGDLFHERYR
                     QDLVREFAMIKQVTKENGAYATYLSGAGPTVMVLASHDKMPTIKAELEKQPFKGKLHD
                     LRVDTQGVRVEAK"
     gene            complement(15896..17182)
                     /locus_tag="VVR18_000134"
     CDS             complement(15896..17182)
                     /locus_tag="VVR18_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HEU6031738.1"
                     /translation="MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVK
                     DEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVV
                     TANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
                     GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMK
                     IAFDDVAHKGIRNITPEDVAVAQELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLA
                     SVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEY
                     SRDLVLANPEDVKANYYFSILALDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARV
                     VIITHKINKAQLENVLAELKKVSEFDLLNTFKVLGE"
     gene            complement(17333..18070)
                     /gene="mecA"
                     /locus_tag="VVR18_000135"
     CDS             complement(17333..18070)
                     /gene="mecA"
                     /locus_tag="VVR18_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adaptor protein MecA"
                     /protein_id="HEU6031739.1"
                     /translation="MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAI
                     LDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMS
                     PDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
                     KLADLVVFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDS
                     DISRSVLQEYGQVLMSHDAVLNLQKIG"
     gene            complement(18270..19304)
                     /locus_tag="VVR18_000136"
     CDS             complement(18270..19304)
                     /locus_tag="VVR18_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HEU6031740.1"
                     /translation="MFEHYSVADLFANLYKKRKANILALIALFALIAVPFTIKAVRNK
                     NTVKDTTSYSTYLIYKITPPEESAKTILNHQIGGYSDFYGKLIDGNLNGAYLFNDVEP
                     SELKKIASELDTTETTLKNSTNDYWWKKLTVYYMIDDAGVGVKILTSSKDANDLLEKK
                     IDGLIEKFKHAYANVKIEKLETINSKELNANGETALGLNVKNLILRLVVIGVVCVILV
                     VMGNVLVYLFNPTINRVGDFSQYQIDFVTEITTIANLADVLSYKNTGQELTIVSSNKA
                     ILDKLKQSQEALKGMHFVDLQDVSSLLERDTVLLVEEYGVTRYKKFEQSLQILRNLNR
                     SILGVATFKL"
     gene            complement(19333..20766)
                     /locus_tag="VVR18_000137"
     CDS             complement(19333..20766)
                     /locus_tag="VVR18_000137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polysaccharide polymerase Wzy family
                     protein"
                     /protein_id="HEU6031741.1"
                     /translation="MIDGKRLLFSLTIVSYALTLVSGIVYLFNNNNVSLLSTLLFLLV
                     SSLIACWNDIKYYLIHFIFYLTIFVFLVSRPTIDYFRDGALDTYHPIAYRFAFIVVMV
                     SILGLTTGGVLARYFIARKKIKVANIGNSLKEVYIKRLRFVSLGVFLLTYPFYFIRLF
                     ERLLYRLQTSYYAYYANFESKLPYFTYILSTFTVYAMCMYLATKPKKLQATAVLVSFI
                     AANTIHLAIGTRNPFILSILFAFVYYFMREQAEKGKWIGFKEKLAIFVGSPILMLAMG
                     VLNYVRDNVQVSHTGFWDILLDFIYKQGTSFGVLARGFLFNSSLPYRDFRNFTFGPVL
                     DYFARGSLGAIFGGKAFEHTTNSVELAIDSNSYAHNLSYLVLNKEYLKGHGIGSSYIM
                     ELYTDYGMIGVFLLSFLLGVLFIAMLQVAYRSRTILFALSLLILNNLFFMPRSSFSES
                     FFNLFTMQFWGIVLVIIFVAKMLTKEN"
     gene            complement(20782..21768)
                     /locus_tag="VVR18_000138"
     CDS             complement(20782..21768)
                     /locus_tag="VVR18_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000446977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU6031742.1"
                     /translation="METALISVIVPVYNVAQYLEKSIASIQKQTYQNLEIILVDDGAT
                     DESGRLCDSIAEQDDRVSVLHKKNEGLSQARNDGMKQAHGDYLIFIDSDDYIHPEMIQ
                     SLYEQLVQEDADVSSCGVMNVYANDESPQSANQDDYFVCDSQTFLKEYLIGEKIPGTI
                     CNKLIKRQIATDLSFPKGLIYEDAYYHFDLIKLAKKYVVNTKPYYYYFHRGDSITTKP
                     YAEKDLAYIDIYQKFYNEVVKNYPDLKEVAFFRLAYAHFFILDKMLLDDQYKQFEAYS
                     QIHRFLKGHAFAISRNPIFRKGRRISALALFINISLYRFLLLKNIEKSKKLH"
     gene            complement(21770..22873)
                     /locus_tag="VVR18_000139"
     CDS             complement(21770..22873)
                     /locus_tag="VVR18_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEU6031743.1"
                     /translation="MVAKKKILFFMWSFSLGGGAEKILSTIVSNLDPEKYDIDILEME
                     HFDKGYESVPKNVRILKSLQDYRQTRWLRAFLWRMRIYFPRLTRRLLVKDDYDVEVSF
                     TIMNPPLLFSKRREVKKISWIHGSIEELLKDSSKRESHRSQLDAANTIVGISKKTSNS
                     IKEVYPDYASKLQTIYNGYDFQTILEKSQEKIDIEIAPQSICTIGRIEENKGSDRVVE
                     VIRLLHQEGKNYHLYFIGAGDMEEELKKRVKEYEIEDYVHFLGYQKNPYQYLSQTKVL
                     LSMSKQEGFPGVYVEALSLGLPFISTDVGGAEELSQEGRFGQIIESNQEAAQAITNYM
                     TSASNFDVDEASQFIQQFTITKQIEQVEKLLEE"
     gene            complement(22863..23708)
                     /locus_tag="VVR18_000140"
     CDS             complement(22863..23708)
                     /locus_tag="VVR18_000140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEU6031744.1"
                     /translation="MNNMTDLKAIQARSLEMAEYFVAFCKEHDLLCYLCGGGAIGALR
                     NKGFIPWDDDLDFFMPRKDYEKLAELWPRYADERYFLSKSHKNFVDRNLFITIRDKET
                     TCIKPYQQDLDLPHGLALDVLPLDYYPKNPAERKKQVRWALIYSLFCAQTIPEKHGAL
                     MKWGSRILLGLTPKSLRYRIWKKAEKEMTKYDLADCDGITELCSGPGYMRNKYPITSF
                     EDNLFLPFEGTEMPIPIGYDVYLRTAFGDYMTPPPADKQVPHHDAVIADMDKSYTEYK
                     GEYGG"
     gene            complement(23987..25261)
                     /gene="psr"
                     /locus_tag="VVR18_000141"
     CDS             complement(23987..25261)
                     /gene="psr"
                     /locus_tag="VVR18_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyisoprenyl-teichoic acid--peptidoglycan
                     teichoic acid transferase Psr"
                     /protein_id="HEU6031745.1"
                     /translation="MSKENPLSHHEQLRYDYLLKNIHYLNEREKNEFAYLQEKLTLAR
                     GNSSSSLEQEREEQVDLPSYANRSRSQSKSQALSFPPKKKRRKLRLKRIFMVIFSLLV
                     CVALAMVFMFLRGYQDASAKKTADARAAQVEVFNGQDTRDGVNILIMGTDGRIGQNSV
                     ETRTDSIMVLNVGGSDKKMKLVSFMRDNLVYIDGYSQVINGRKQTDNKLNVAYELGEQ
                     EGQKGAEMVRQVLKDNFDLDIKYYALVDFQAFATAIDTLFPDGVTIDAQFSTLNGRPL
                     TEATVGDDLYATETESPTQTIKVGKQQMNGSTLLNYARFRDDDEADYGRTKRQQQVLT
                     AILEQIKDPTKLFTGSEALGKVFAMTSTNVPYTFLLTNGLSVLDGAKNGIEKLTIPEL
                     GDWVDAYDVYGGLGLLVDQNKYQTKLAQMGLR"
     gene            complement(25258..26106)
                     /gene="pheA"
                     /locus_tag="VVR18_000142"
     CDS             complement(25258..26106)
                     /gene="pheA"
                     /locus_tag="VVR18_000142"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HEU6031746.1"
                     /translation="MKIAYLGPKGSFSHHVVQIAFPHEELQAFANITDVIKAYEQGLV
                     DYSVVPVENSIEGSVHETLDYLFHQAHIQAVAEIVQPIHQQLMVVPGHTKIEKIFSHP
                     QALAQGKKFIDEQYPEAQIEVTASTAYAARFISEHPDQPFAAVAPRSSAEEYGLELIA
                     EDIQEMEANFTRFWLLGAEKPSIPLQAQTEKMSLALTLPDNLPGALYKALSTFAWRGI
                     DLTKIESRPLKTALGEYFFIIDVDYTDKDLVHFAQKELEAIGIQYKILGAYPIYPISD
                     HGKERR"
     gene            complement(26103..26579)
                     /locus_tag="VVR18_000143"
     CDS             complement(26103..26579)
                     /locus_tag="VVR18_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HEU6031747.1"
                     /translation="MAKVLLGFMGAGKSTIARGLNPNYLDMDALIEKRLGMSIANFFA
                     EKGEAAFRQVESEVLADLLQTDQVVSTGGGVVISQRNRDLLKTNTDNIYLKADFETLY
                     QRIAADKDNQRPLFLNNSKEELVAIFQERQAWYEEVASRVLDVTKLSPEEIIEELR"
     gene            complement(26572..27855)
                     /gene="aroA"
                     /locus_tag="VVR18_000144"
     CDS             complement(26572..27855)
                     /gene="aroA"
                     /locus_tag="VVR18_000144"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HEU6031748.1"
                     /translation="MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILR
                     GEDVLSTMQVFRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVL
                     AGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHY
                     ELPIASAQVKSALMFAALQAKGESVIIEKECTRNHTEDMLKQFGGHLSVDGKKITVQG
                     PQKLTGQKVVVPGDISSAAFWLVAGLIVPNSRLVLQNVGINETRTGIIDVIRAMGGKL
                     EITEIDPVAKSSTLTVESSDLKGTEIGGALIPRLIDELPIIALLATQAQGVTVIKDAE
                     ELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAI
                     AALLVADGEVELDRAEAINTSYPSFFDDLESLIHG"
     gene            complement(27947..28285)
                     /locus_tag="VVR18_000145"
     CDS             complement(27947..28285)
                     /locus_tag="VVR18_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbF/YmcA family competence regulator"
                     /protein_id="HEU6031749.1"
                     /translation="MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTEY
                     LAFQEEIQKLAHTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKI
                     VFEPVSELLK"
     gene            complement(28296..29399)
                     /locus_tag="VVR18_000146"
     CDS             complement(28296..29399)
                     /locus_tag="VVR18_000146"
                     /EC_number="1.3.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HEU6031750.1"
                     /translation="MAKTIYIAGLGLIGASMALGIKRDHPDYEILGYNRSQASRDIAL
                     KEGMIDRATDDFASFAPLADVIILSLPIKQTIAFIKELANLDLREGVIISDAGSTKST
                     IVDAAEQYLAGKSVRFVGAHPMAGSHKTGAASADVNLFENAYYIFTPSSLTSQDTLKE
                     MKDLLSGLHARFIEIDAKEHDRVTSQISHFPHILASSLMEQTAVYAQEHEMARRFAAG
                     GFRDMTRIAESEPGMWTSILLSNSETILDRIEDFKERLEVIGQAISKGDEEQIWNFFN
                     QAREQRQTMEIHKRGGVDSSYDLYVDVPDEEDVILRILELLRGTSLVNIHINEENRED
                     IHGILQISFKNAQDLERAEHLITENTDYTVVIK"
     gene            complement(29409..30575)
                     /gene="aroC"
                     /locus_tag="VVR18_000147"
     CDS             complement(29409..30575)
                     /gene="aroC"
                     /locus_tag="VVR18_000147"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HEU6031751.1"
                     /translation="MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYG
                     RGGRMKIESDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSKRK
                     ITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANH
                     VVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVV
                     ETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEI
                     LWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKAT
                     VERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY"
     gene            complement(30585..31652)
                     /locus_tag="VVR18_000148"
     CDS             complement(30585..31652)
                     /locus_tag="VVR18_000148"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002308136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HEU6031752.1"
                     /translation="MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNH
                     VASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVAL
                     GGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQP
                     DGVLIDPLVLETLGKKELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLI
                     EHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISK
                     VAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVP
                     ELGSAIIHPVSLEEMKDYLVK"
     gene            complement(31671..32525)
                     /locus_tag="VVR18_000149"
     CDS             complement(31671..32525)
                     /locus_tag="VVR18_000149"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HEU6031753.1"
                     /translation="MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEI
                     EASDLVETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLI
                     GYNTDGKGFFKCLPSFTISGKKMILLGAGGAAKSILAQAILDGVSQISVFVRSVSMEK
                     TRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQFSPVPENIVL
                     PETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIW
                     QSLTEKYQ"
     gene            complement(32515..33192)
                     /locus_tag="VVR18_000150"
     CDS             complement(32515..33192)
                     /locus_tag="VVR18_000150"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HEU6031754.1"
                     /translation="MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQV
                     APAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKD
                     VFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNY
                     TRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKI
                     REILDEA"
     gene            complement(33189..34352)
                     /locus_tag="VVR18_000151"
     CDS             complement(33189..34352)
                     /locus_tag="VVR18_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent rRNA methyltransferase"
                     /protein_id="HEU6031755.1"
                     /translation="MNRIRVSKRVEKKLAKGLVLLEASDLENVNLKDREVEVQGQEGN
                     FLGTAYLSQQNKGLGWFISKDKVAFNQAFFETLFRKAKEKRNAYYQDDLTTAFRLFNQ
                     EGDGFGGLTVDLYGDYAVFSWYNSYVYQIRQTISEAFRQVFPEVLGAYEKIRFKGLDY
                     ESAHVYGQEAPDFFTVLENGVLYQVFMNDGLMTGIFLDQHEVRGSLVDGLAMGKSLLN
                     MFSYTAAFSVAAAMGGASQTTSVDLAKRSRELSQAHFQANGLSTDEHRFIVMDVFEYF
                     KYAKRKNLTYDVIVLDPPSFARNKKQTFSVAKDYHKLISQSLEILNPGGIIIASTNAA
                     NVSRQKFTEQIDKGFAGRSYQILNKYGLPADFAYNKKDESSNYLKVISMKVSK"
     gene            complement(35037..36671)
                     /locus_tag="VVR18_000152"
     CDS             complement(35037..36671)
                     /locus_tag="VVR18_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031756.1"
                     /translation="MRLKVIKKLVDINILYSSQEANLANLRKKQAKNPGKKVNVSARV
                     LSSYIFSSLLMLICFSNIAIHFPFEEMPIYFSSMVAILLVLAFSTSFTAFYNVFYESK
                     DLASYRPYAFKESEIIMAKGLSVLLPALTGIVPILAYFLALYISLAPSLWLGLPLMLL
                     SLTLLFVSVTLVTVVAVHFLAQTRVFRKYQSIFSNVMIGIGVLIPLIFIFFLQSTFGS
                     IVDKVRDIPFLLYPLHIFYKIAVEPFSTEALVGLLAWIGLTLFLLYLTKKKVLPRFYD
                     VILLNSEEKVKKERRSKERISTTKKGFFRMVLRYHLTLLGQGTGVITVLFTSAFLPYL
                     MMISLISKIRDSQIVPDIHPPYWLPLFFVGVFIAVVNNNITSLHSIALSLERENVDFL
                     KSLPFDFARYVKVKFWIIFAVQSFLPVLTLLGLSLYLGLSILSMIYLLVVWIIASVIL
                     SCHHYFKDVKNLSTNWSSITDLVNRSNGIVAIVLLFIYSAILMALVIGSIFLVQSLSP
                     ILAINLGVGALIVLLALAIFGYHYYLSRILAEIEKR"
     gene            complement(36652..37401)
                     /locus_tag="VVR18_000153"
     CDS             complement(36652..37401)
                     /locus_tag="VVR18_000153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6031757.1"
                     /translation="MIEFQNVSKLYGDKEALSNLNLQIENGEIMGLIGHNGAGKSTTI
                     KSLVSIISPSSGRILVDGQELSENRLAIKRKIGYVADSPDLFLRLTANEFWELIASSY
                     DLTSSDLETSLARLLNVFDFAENRYQVIETLSHGMRQKVFVIGALLSAPDIWVLDEPL
                     TGLDPQAAFDLKQMMKEHAQKGKTVLFSTHVLEVAEQVCDRIAILKKGHLIYCGSVEN
                     LRKDHPDQFLESIYLSLAGRKEEVADASQGH"
     gene            37580..39034
                     /locus_tag="VVR18_000154"
     CDS             37580..39034
                     /locus_tag="VVR18_000154"
                     /EC_number="3.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-amylase"
                     /protein_id="HEU6031758.1"
                     /translation="MQNQTLMQYFEWYLPHDGQHWTRLAENAPHLAHLGISHVWMPPA
                     FKATNEKDVGYGVYDLFDLGEFNQKGTVRTKYGFKEDYLQAIQALKEQGIQPMADVVL
                     NHKAAADNREAFQVIEVDPVDRTVELGEPFTINGWTSFTFDGRQDTYNGFHWHWYHFT
                     GTDYDAKRSKSGIYLIQGDNKGWANEELVDNENGNYDYLMYADLDFKHPEVIQNIYDW
                     ADWFMETTGVAGFRLDAVKHIDSFFMRNFIRDMKEKYGDDFYVFGEFWNPDKEANLDY
                     LEKTEEHFDLVDVRLHQNLFEASQAGANYDLRGIFTDSLVELKPDKAVTFVDNHDTQR
                     GQALESTVEEWFKPAAYALILLRQDGLPCVFYGDYYGISGQYAQEDFKEILDRLLAIR
                     KDLAYGEQNDYFDHANCIGWVRSGAENQSPIAVLISNDQENSKSMFVGQEWTNQTFVD
                     LLGNHQGQVTIDEEGYGQFPVSARSVSVWAVNTI"
     gene            complement(39124..41742)
                     /gene="alaS"
                     /locus_tag="VVR18_000155"
     CDS             complement(39124..41742)
                     /gene="alaS"
                     /locus_tag="VVR18_000155"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HEU6031759.1"
                     /translation="MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSG
                     VATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRD
                     EAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI
                     GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRS
                     EYKELPHKNIDTGAGLERLVAVIQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMS
                     FKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTV
                     GKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQ
                     DVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNE
                     TLQNITVESVFNYNTSQLSSKLVAIVADNAEVGAVSEGTASLIFAETSFYAEMGGQVA
                     DYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKN
                     HTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIW
                     EALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGL
                     FKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAVAATLKAPQVKEVPHKVEGLQ
                     EQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIASQVSVSDAGALRTFADNWK
                     QKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGS
                     NQPKIQELLDAVAGKL"
     gene            complement(41764..42249)
                     /locus_tag="VVR18_000156"
     CDS             complement(41764..42249)
                     /locus_tag="VVR18_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000847073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LURP-one-related family protein"
                     /protein_id="HEU6031760.1"
                     /translation="MKTFLVKQKFRLGGERFAIKNDRGEIAYQVEGSFFKIPKTFTIY
                     DAAGEQVSQISKEILTLLPRFEIQLRDGSSFVIRKKLTFWRDKYEFDNLGLRIEGNIW
                     DLNFQLLDDRDQLIAEIKKELFHLTSTYTVTVLEDAYADLVISLCVAIDYVEMLESQS
                     H"
     gene            complement(42524..42763)
                     /locus_tag="VVR18_000157"
     CDS             complement(42524..42763)
                     /locus_tag="VVR18_000157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000784186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031761.1"
                     /translation="MKMSTFFKKSFWPTFMIVNQTAILFHLKDGLDRQYLTTESIYWV
                     IGTFIFGNILVAVFSTMKIWDKKKNGSKKKYILKK"
     gene            complement(43032..44102)
                     /locus_tag="VVR18_000158"
     CDS             complement(43032..44102)
                     /locus_tag="VVR18_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU6031762.1"
                     /translation="MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGD
                     YIDPELLTQFTEETGIQVQYETFDSNEAMYTKIKQGGTTYDIAIPSEYMINKMKDEDL
                     LVPLDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDL
                     WKPEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDLQQLEETVDKLYKLTPNIKAIVAD
                     EMKGYMIQNNVAIGVTFSGEASQMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQNS
                     AYAFINFMLKPENALQNAEYVGYSTPNLPAKELLPEETKEDKAFYPDVETMKHLEVYE
                     KFDHKWTGKYSDLFLQFKMYRK"
     gene            complement(44099..44872)
                     /locus_tag="VVR18_000159"
     CDS             complement(44099..44872)
                     /locus_tag="VVR18_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6031763.1"
                     /translation="MKKFANLYLGLVFLVLYLPIFYLIGYAFNAGDDMNSFTGFSWTH
                     FETMFGDGRLMLILAQTFFLAFLSALIATIIGTFGAIYIYQSRKKYQEAFLSLNNILM
                     VAPDVMIGASFLILFTQLKFSLGFLTVLSSHVAFSIPIVVLMVLPRLKEMNGDMIHAA
                     YDLGASQFQMFKEIMLPYLTPSIITGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYS
                     RARKGISLEINALSALVFLFSIILVVGYYFISREKEEQA"
     gene            complement(44869..45675)
                     /locus_tag="VVR18_000160"
     CDS             complement(44869..45675)
                     /locus_tag="VVR18_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6031764.1"
                     /translation="MKKTSSKLFVVPYMLWIALFVLAPLVLIFGQSFFNIEGQFSLEN
                     YKSYFASQNLTYLKMSFNSVLYAGIVTFVTLLISYPTALFLTRLKHRQLWLMLIILPT
                     WINLLLKAYAFIGIFGQNGSINQFLEFIGIGSQQLLFTDFSFIFVASYIELPFMILPI
                     FNVLDDMDNNLINASYDLGATKWETFRHVIFPLSMNGVRSGVQSVFIPSLSLFMLTRL
                     IGGNRVITLGTAIEQNFLTNDNYGMGSTIGVILILTMFITMWVTKERRER"
     gene            complement(45656..46813)
                     /locus_tag="VVR18_000161"
     CDS             complement(45656..46813)
                     /locus_tag="VVR18_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018372333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6031765.1"
                     /translation="MKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGS
                     GKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVHTVFQSYALFPHMNVFENVAF
                     PLRLRNIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVL
                     LDEPLSALDLKLRTDMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQ
                     SGTPVDIYDEPINHFVATFIGESNILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEV
                     VIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIVGEEIG
                     LDFEPEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKL"
     gene            complement(46974..47879)
                     /gene="murB"
                     /locus_tag="VVR18_000162"
     CDS             complement(46974..47879)
                     /gene="murB"
                     /locus_tag="VVR18_000162"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000116193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HEU6031766.1"
                     /translation="MSVREKMLEILEGIDIRFQEPLHSYSYTKVGGEADYLVFPRNRF
                     ELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGA
                     NLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEI
                     ETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEY
                     PSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQ
                     SVIEKVKEHSGITLEREVRILGESK"
     gene            complement(47991..48743)
                     /locus_tag="VVR18_000163"
                     /pseudo
     CDS             complement(47991..48743)
                     /locus_tag="VVR18_000163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152219.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhfC family intramembrane metalloprotease"
     gene            complement(48753..49484)
                     /gene="budA"
                     /locus_tag="VVR18_000164"
     CDS             complement(48753..49484)
                     /gene="budA"
                     /locus_tag="VVR18_000164"
                     /EC_number="4.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate decarboxylase"
                     /protein_id="HEU6031767.1"
                     /translation="MDKNVQEPVKLFQYNTLGALMAGLYGGTMTVGELLEHGDLGLGT
                     LDSIDGELIVLDGKAYQAKGSGDQPEIVEVSPDALIPYAAVVPHQAEVIFRQRFEMTD
                     KELKERIESYYDGENLFRSIKIRGEFSHMHVRMIPKSTPDTKFADVATHQPEYSRDNV
                     VGTIVGFWTPEIFHGVSVAGYHLHFISDDLTFGGHVMDFVIKEGIIEVGAIDQLDQRF
                     PVQDRQYLFAKFNVDEMKKDIEKAE"
     gene            49626..50897
                     /locus_tag="VVR18_000165"
     CDS             49626..50897
                     /locus_tag="VVR18_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HEU6031768.1"
                     /translation="MKKQSKYKEVVSYLKNGIESERFPTGSRLPSIRQLSLDFHCSKD
                     TIQRALLELRHEQYLYAKPQSGYYVLEQGQHQDLEIEVTDEHASAYDDFRLCVNETLI
                     GRENYLFNYYDNQEGLEDLRQSIHKLLFEQALYCKANQLVLTSGTQQALFILSQISFP
                     RQAKEILVEQPTYHRMNRLLIAQGLDYQTIERGIDGIDLEELEGHFKTGKIKFFYTIP
                     RFHYPLGHSYSEQDKRAILDLAAKYSVYIVEDDYLGDLDSKKGQTFHYLDTEERVIYI
                     KSFSTSLFPALRITALILPNTIKEAFVAYKNILDYDSNLIMQKALSLYIDSQLFEKNR
                     LARLTNHESYQKQIEERITKTPCPLPHYPLHDGLLLDLRQYPKIASLKHSQLGLDFFE
                     EAYLSTCPYQFAKVSLDNLENVLNYLKAELE"
     gene            complement(50917..51732)
                     /locus_tag="VVR18_000166"
     CDS             complement(50917..51732)
                     /locus_tag="VVR18_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEU6031769.1"
                     /translation="MKSKKWIFVLCNFLASFFLVACQSGSNGSQSAVDAIKQKGKLVV
                     ATSPDYAPFEFQSLVDGKNQVVGADIDMAQAIADELGVKLEILSMSFDNVLTSLQTGK
                     ADLAVAGISATDERKEVFDFSIPYYENKISFLVRKADVEKYKDLTSLESANIAAQKGT
                     VPESMVKAQLPKAQLTSLTNMGEAVNELQAGKIDAVHMDEPVALSYAAKNAGLAVATV
                     SLKMKDGDANAVALRKNSDDLKEVVDKVIQKLKDEGTYQSYLEKAASLTEVEE"
     gene            complement(51889..52542)
                     /gene="phoU"
                     /locus_tag="VVR18_000167"
     CDS             complement(51889..52542)
                     /gene="phoU"
                     /locus_tag="VVR18_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000946475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEU6031770.1"
                     /translation="MLRSQFEEDLEKLHNQFYAMGQEVLSQINRTVRAFVTHDRDLAK
                     EVIEDDAEVNEYEVKLEKKSFEMIALQQPVSQDLRTVLTVLKAVSDVERMGDHAVAIA
                     QATIRMKGEERIPAVEEEIKKMGREVKSVVEAALDLYLNGSVDDAYRVASMDEQINHY
                     FETIRDLATEEIKKNPEAIVTGRDYFQVISYLERIGDYAKNICEWVVYFETGKIVEL"
     gene            complement(52554..53312)
                     /gene="pstB"
                     /locus_tag="VVR18_000168"
     CDS             complement(52554..53312)
                     /gene="pstB"
                     /locus_tag="VVR18_000168"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEU6031771.1"
                     /translation="MTDAILQVSDLSVYYNKKKALNSVSLSFQPKEITALIGPSGSGK
                     STLLKSLNRMGDLNPEVTTTGSVVYNGHNIYSPRTDTVELRKEIGMVFQQPNPFPMTI
                     YENVVYGLRINGIKDKQVLDEAVEKALQGASIWDEVKDRLYDSAIGLSGGQQQRVCVA
                     RVLATSPKIILLDEPTSALDPISAGKIEETLYGLKDKYTMLLVTRSMQQASRISDKTG
                     FFLDGDLIEFNDTKQMFLDPQHKETEDYITGKFG"
     gene            complement(53325..54128)
                     /gene="pstB"
                     /locus_tag="VVR18_000169"
     CDS             complement(53325..54128)
                     /gene="pstB"
                     /locus_tag="VVR18_000169"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEU6031772.1"
                     /translation="MSTYNWDEKHILTFPEEKVALSTKDVHVYYGKNESIKGIDMQFE
                     RNKITALIGPSGSGKSTYLRSLNRMNDTIDIAKVTGQILYRGIDVNRPEINVYEMRKH
                     IGMVFQRPNPFAKSIYRNITFAHERAGVKDKQVLDEIVETSLRQAALWDQVKDDLHKS
                     ALTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKNFTIIIV
                     THNMQQAARASDYTGFFYLGDLIEYDKTATIFQNAKLQSTNDYVSGHFG"
     gene            complement(54139..55023)
                     /gene="pstA"
                     /locus_tag="VVR18_000170"
     CDS             complement(54139..55023)
                     /gene="pstA"
                     /locus_tag="VVR18_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009443446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEU6031773.1"
                     /translation="MRAKKLDKLATAVLYTIASIIVTILASLILYILVRGLPHISWSF
                     LTGRSSAFQAGGGIGIQLYNSFFLLVITLIISVPLSMGAGIYLAEYAKKGPVTNFVRT
                     CIEILSSLPSVVVGLFGYLIFVVQFEYGFSIISGALALTVFNLPQMTRNVEDSLKHVH
                     HTQREAGLALGISRWETVVHVVIPEALPGIVTGVVLASGRIFGEAAALIYTAGQSAPA
                     LDWSNWNILSVTSPISIFRQAETLAVHIWKVNSEGTIPDGTIVSAGSAAVLLIFILIF
                     NFGARKFGSYLHKKLTAA"
     gene            complement(55013..55930)
                     /gene="pstC"
                     /locus_tag="VVR18_000171"
     CDS             complement(55013..55930)
                     /gene="pstC"
                     /locus_tag="VVR18_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018378778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEU6031774.1"
                     /translation="MNQEELAKKMLLPSKNSRLEKLGKGLTFACLSLIVILVAMILVF
                     VAQKGLSTFFVNGVNIFDFLLGGTWNPSSKEFGALPMILGSFIVTILSALIATPFAIG
                     AAVFMTEVSPKGAKILQPAIELLVGIPSVVYGFIGLQVVVPFVRSVFGGTGFGILSGI
                     SVLFVMILPTVTFMTTDSLRAVPRYYREASFAMGATRWQTIWRVILKAARSGIFTAVV
                     FGMARAFGEALAIQMVVGNSAVIPTSLTTPAATLTSILTMGIGNTVMGTVNNNVLWSL
                     ALVLLLMSLVFNSVIKLITKERGKKNYAR"
     gene            complement(55930..56808)
                     /gene="pstS"
                     /locus_tag="VVR18_000172"
     CDS             complement(55930..56808)
                     /gene="pstS"
                     /locus_tag="VVR18_000172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein PstS"
                     /protein_id="HEU6031775.1"
                     /translation="MKKRKKLALSLIAFWLTACLVGCASWIDRGESITAVGSTALQPL
                     VEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQSGAVDIGNSDVFAEEKDGIDASALVD
                     HKVAVAGLALIVNKEVDVDNLTTEQLRQIFIGEVTNWKEVGGKDLPISVINRAAGSGS
                     RATFDTVIMEGQSAMQSQEQDSNGAVKSIVSKSPGAISYLSLTYIDDSVKSMKLNGYD
                     LSPENISSNNWPLWSYEHMYTLGQPNELAAEFLNFVLSDETQEGIVKGLKYIPIKEMK
                     VEKDAAGTVTVLEGRQ"
     gene            complement(57382..58686)
                     /locus_tag="VVR18_000173"
     CDS             complement(57382..58686)
                     /locus_tag="VVR18_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmF rRNA methyltransferase first C-terminal
                     domain-containing protein"
                     /protein_id="HEU6031776.1"
                     /translation="MKFPEGFVEKYKEILGDEARDFLASFEEEAVSAFRVNPLKEEQL
                     SFSDAITQTPWGHYGKVSGKSPEHATGLVYSQEPAAQMVAQVAQPSPGMKVLDLAAAP
                     GGKSTQLAAYLAGEGLLVSNEISSKRAKILVENMERFGATNVVVTNESADRLVKVFKG
                     YFDLIVLDAPCSGEGMFRKQPDAMDYWSLHYPSQCASLQREILEDAVTMLAEGGRLVY
                     STCTWAPEENEEIVNWLLEEYDFDLLPVEHINGMVAGIDLPETARMYPHQFKGEGQFV
                     AHLQFKGNNPAPKFKASKSNLSREQVALWQEFAQNHLKVNLPGILQTFGDQLYLLPEL
                     LPDLGKLKIARNGLHLGTFKKKRFEPSFALGLALKSSQVEQSVEIGQEAFVKYAAGEI
                     VQLAESLPNGWYQVLVKGNGLGFAKVTGNVLKNYFPKGLRFK"
     gene            complement(58687..59460)
                     /locus_tag="VVR18_000174"
     CDS             complement(58687..59460)
                     /locus_tag="VVR18_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="inositol monophosphatase family protein"
                     /protein_id="HEU6031777.1"
                     /translation="MESKFEFAKELVKKAGQYILDHMQEDLRVETKSSPTDLVTRLDK
                     EVQELLVGEILSRYPEDKICAEEGCLRASVQEGKVWVIDPIDGTNNFVAQQEDFAVMM
                     AYFENGQGQFGLIYDVVKGDCYHGGGEFPVCLNDRPLAPFKTKPLGDFLIAGNSGMLE
                     TNEWGLADLSRAVLGVRIYGSAAISFAKILSGHLLTYLTYLQPWDYAAASILGESLGY
                     RVVTLFGEAPDFQTRQPVMMVPLEMQEEIQSYIYERKRT"
     gene            complement(59450..59728)
                     /locus_tag="VVR18_000175"
     CDS             complement(59450..59728)
                     /locus_tag="VVR18_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0223 family protein"
                     /protein_id="HEU6031778.1"
                     /translation="MNKQYSYPLDLSWSTEELASVLSFFNDVEAAYEGKVEAKKLLDS
                     YKGFKAVVPSKSEEKRLGREFETVSGYSLYRAVQAAKEKGEGKISLGK"
     gene            complement(59728..60129)
                     /locus_tag="VVR18_000176"
     CDS             complement(59728..60129)
                     /locus_tag="VVR18_000176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007556665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spx/MgsR family RNA polymerase-binding
                     regulatory protein"
                     /protein_id="HEU6031779.1"
                     /translation="MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQH
                     ILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSLLRRPIIIDAKRMQ
                     IGFNEDEIRAFLPRSYRKQELKEARMRAGIS"
     gene            complement(60339..60956)
                     /locus_tag="VVR18_000177"
     CDS             complement(60339..60956)
                     /locus_tag="VVR18_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HEU6031780.1"
                     /translation="MKTKLTFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVY
                     LKPETIQYNFHILMNYLTNPFSQVLQMPDFRSSAAGLHHFAVVKNLFHLVQLVALVTL
                     PSFYVFVNRIVKKDFLSLYRKSLLALVVLPVMIGLGGVLIGFDQFFTLFHQILFVGDD
                     TWLFDPAKDPVIMILPETFFLHAFLLFFALYENFFGYLYLKSRRK"
     gene            complement(60946..61719)
                     /locus_tag="VVR18_000178"
     CDS             complement(60946..61719)
                     /locus_tag="VVR18_000178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01457 family HAD-type hydrolase"
                     /protein_id="HEU6031781.1"
                     /translation="MKYKGYLIDLDGTIYKGKDRIPAGETFVHELQKRGIPYLFVTNN
                     TTRTPESVKEMLAQNFNIDTPLSTVYTATLATIDYMNDLGLEKTVYVVGEAGLKEAIK
                     AAGYVEDKENPAYVVVGLDWQVDYEKFATATLAIQKGAHFIGTNPDLNIPTERGLLPG
                     AGSLITLLEVATRVKPVYIGKPNAIIMDKAVEHLGLEREELIMVGDNYLTDIRAGIDN
                     GIPTLLVTTGFTKAEEVAGLPIAPTHVVSSLAEWDFDEN"
     gene            complement(61730..62467)
                     /locus_tag="VVR18_000179"
     CDS             complement(61730..62467)
                     /locus_tag="VVR18_000179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000524807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-[acyl-carrier-protein] thioesterase"
                     /protein_id="HEU6031782.1"
                     /translation="MGLTYQMKMKIPFDMADMNGHIKLPDVILLSLQVSGMQSIELGV
                     SDKAILEDYNLVWIIAEYDIEVVRLPRFAEEITIETEALSYNRLFCYRRFTIYNEAGQ
                     ELIHMMATFVLMDRDSRKVHAVEPEIVAPYQSDFDKKLIRGPKYESLEEPISKDYHVR
                     FYDLDMNGHVNNSKYLDWIFEVMGADFLTHYIPKKINLKYVKEVRPGGVITSVVERTG
                     LESKHEITSDGVINAQAIITWQEIKKA"
     gene            complement(62472..63602)
                     /locus_tag="VVR18_000180"
     CDS             complement(62472..63602)
                     /locus_tag="VVR18_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HEU6031783.1"
                     /translation="MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEE
                     FRSYDIEKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLDAD
                     KIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAGFDNISIDLIY
                     ALPGQTMEQVKENVAKAIGLDIPHMSLYSLILENHTVFMNRMRRGKLPLPKEELEAEM
                     FEYIIAELERAGFEHYEISNFSKPGFESRHNLMYWDNAEYYGIGAGASGYVNGVRYKN
                     HGPIRHYLSAVEEGNACITEDHLSQKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAG
                     LYGEIVRDLVQQGLMQIEGDHVRMTKRGLFLGDTVAERFILE"
     gene            complement(63686..64075)
                     /locus_tag="VVR18_000181"
     CDS             complement(63686..64075)
                     /locus_tag="VVR18_000181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEU6031784.1"
                     /translation="MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDP
                     EYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEITVDSILAQAKSYAFQATEASKNQL
                     NNLKEQWQEKAEALDDSEEIVIDITEE"
     gene            complement(64091..64474)
                     /locus_tag="VVR18_000182"
     CDS             complement(64091..64474)
                     /locus_tag="VVR18_000182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HEU6031785.1"
                     /translation="MLEVAYILVALALIVFLVYLIITVQKLGRVIDETEKTIKTLTSD
                     VDVTLHHTNELLAKVNVLADDINVKVATIDPLFSAVADLSLSVSDLNDHARVLSKKAS
                     SAGSKTLKTGASLSALRLASKFFKK"
     gene            complement(64475..65263)
                     /locus_tag="VVR18_000183"
     CDS             complement(64475..65263)
                     /locus_tag="VVR18_000183"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000609710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HEU6031786.1"
                     /translation="MLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPD
                     DILDFILVAFPLAILGARLYYVIFRFDYYSQNLGEIFAIWNGGLAIYGGLITGALVLY
                     IFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQMY
                     IEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMR
                     TDSLMFFSLRVSQWLSVVLIGLGIMIVIYQNRKKAPYYITEEEK"
     gene            complement(65256..66191)
                     /locus_tag="VVR18_000184"
     CDS             complement(65256..66191)
                     /locus_tag="VVR18_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HEU6031787.1"
                     /translation="MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYF
                     DYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAA
                     RECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKS
                     ETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGAS
                     AVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIE
                     AAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA"
     gene            complement(66321..66497)
                     /locus_tag="VVR18_000185"
     CDS             complement(66321..66497)
                     /locus_tag="VVR18_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000048061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HEU6031788.1"
                     /translation="MSKTVVRKNESLDDALRRFKRAVTKAGTLQETRKREFYEKPSVK
                     RKRKSEVARKRKKF"
     gene            complement(66637..67344)
                     /locus_tag="VVR18_000186"
     CDS             complement(66637..67344)
                     /locus_tag="VVR18_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HEU6031789.1"
                     /translation="MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYK
                     EIVESNLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNA
                     EAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARF
                     FAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNH
                     PDVTIIADAEALSLLEK"
     gene            67495..68523
                     /gene="queA"
                     /locus_tag="VVR18_000187"
     CDS             67495..68523
                     /gene="queA"
                     /locus_tag="VVR18_000187"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HEU6031790.1"
                     /translation="MNTADFDFHLPEELIAQTPLEKRDASKLLIVNRETGEMQDKHFH
                     SIINMLEPGDALVMNDTRVLPARLYGQKVETGGHVELLLLKNTSGDEWEVLAKPAKRL
                     KVGTRISFGDGRLSAVVTEELTHGGRIVRFEYQRIFLEVLESLGEMPLPPYIHEKLDD
                     RERYQTVYAKESGSAAAPTAGLHFTKELLAEIQAKGVHLVYLTLHVGLGTFRPVSVDN
                     LDEHEMHSEFYQLSEEAAATLRSVKKNGGRVIAVGTTSIRTLETIGSKFDGQIQADSG
                     WTNIFIKPGYEWKVVDAFSTNFHLPKSTLVMLVSAFAGRELVLDAYHHAIQEHYRFFS
                     FGDAMFIY"
     gene            complement(69184..70311)
                     /locus_tag="VVR18_000188"
     CDS             complement(69184..70311)
                     /locus_tag="VVR18_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_135354309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU6031791.1"
                     /translation="MNTSFVHAADGIQYVRDDTRDKEEGIEYDDADNGDIIVKVATKP
                     KVVTKKISSTRIRYEKDETKDRSENPVTIDGEDGYVTTTRTYDVNPETGHVTEQVTVD
                     RKEATDTVIKVPAKSKVEEVLVPCATKYEADNDLSAGQEQEITLGKNGKTVTTITYDV
                     DGKSGQVTESTLSQKEDSQTRVVKKGTKPQVLVQEIPIETEYLDDPTLDKGQEVGEIG
                     KITLTTIYAVDERDGTIEETTSRQITKEMVKRRIRRGTREPEKVVVPEQSSIPSYPVS
                     VTSNQGTDVAVEPAKAVAPTTGWKQENGMWYFYNTDGSMATGWVQVNGSWYYLNSNGS
                     MKVNQWFQVGGKWYYVNASGELAVNTSIDGYRVNDNGEWVR"
     gene            complement(71042..71593)
                     /locus_tag="VVR18_000189"
     CDS             complement(71042..71593)
                     /locus_tag="VVR18_000189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6031792.1"
                     /translation="MKSIGTQILQTERLILRRFVESDAEAMFQNWASSAENLTYVTWD
                     PHPDVEITRNSICNWVASYTNLNYYKWAICLKENPEQVIGDISIVKIDEADLSCEIGY
                     VLGKAYWGNGMMTETLKAILDFCFTQAGFQKVRARYASLNPASGRVMEKAGMSYLQTI
                     VNGVERKGYLADLIYYGISREEC"
     gene            complement(71943..72767)
                     /gene="nadE"
                     /locus_tag="VVR18_000190"
     CDS             complement(71943..72767)
                     /gene="nadE"
                     /locus_tag="VVR18_000190"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ammonia-dependent NAD(+) synthetase"
                     /protein_id="HEU6031793.1"
                     /translation="MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFV
                     LGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIVVRLPYGVQADEADAQKALAFIQ
                     PDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGT
                     DHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQELGADPALYEKIPTADLEEDK
                     PGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE"
     gene            complement(72764..74224)
                     /locus_tag="VVR18_000191"
     CDS             complement(72764..74224)
                     /locus_tag="VVR18_000191"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HEU6031794.1"
                     /translation="MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFK
                     NGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGD
                     LVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
                     AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYA
                     ETHKNCVFLVDTYDTLRIGVPAAIQVACELGDQINFMGVRIDSGDIAYISKKVRQQLD
                     EAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIE
                     DETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKM
                     FHPTYTYIKKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRV
                     LNPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE"
     gene            complement(74340..74828)
                     /locus_tag="VVR18_000192"
     CDS             complement(74340..74828)
                     /locus_tag="VVR18_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031795.1"
                     /translation="MKNRFYYYQLLDEREEQLFNKAGSESFYICIALSLLSYIISVLA
                     PSLFNSNMLLIVIIIGTFYFFNRARYLGVTYYSRFHFTILGCFFLTLAITALLMLQNY
                     QFNIEIYQHNPLNFKYLSAWVITYVIYLPWVFIGNLGLKSYGEWAQKKFEQDMDELES
                     GE"
     gene            complement(74818..75027)
                     /locus_tag="VVR18_000193"
     CDS             complement(74818..75027)
                     /locus_tag="VVR18_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6031796.1"
                     /translation="MVKNLKLKLARVELDLTQGQLADAVGVTRQTIGLIEAGKYNPSL
                     SLCQSICRCLGKTLDQLFWEEEDEK"
     gene            complement(75413..75865)
                     /locus_tag="VVR18_000194"
     CDS             complement(75413..75865)
                     /locus_tag="VVR18_000194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000640911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031797.1"
                     /translation="MIYVLSNFLYAISVSIIYALNGIVLLVIVSKLGIPGDLGLDFIV
                     AIVVNTILLVLFYFLLSYIFYLYKLKSGLVFGILVALLLFIPNILNTMMMNTSNDLFI
                     KAIELLPFYSLPVFVTSNTMSISQYLVLITTIILLYFFTLKKSKKYSF"
BASE COUNT        22844 a        17006 c        13806 g        22417 t
ORIGIN      
        1 tacatttata tctttcgtta ttgatgcttc cgttacttct aaatagtaat ttgatatata
       61 gattgctgac caacccagaa tacttatagc accaaatctt agaacgtcag aaaatgagga
      121 agtctgattt aaactacctg catatacaat aattcctgag agcaagacac cattaaacga
      181 agatagaaat attaaaatcc ccattaatat aagtttagtc ttttttataa attttaaata
      241 attcataagt tattccttcc cacttcttca aagaaataat ttaaagtatc aatcattaag
      301 agaacatctg atggagtaaa acctccatga ccagctgctt tgtttaaata caacaaactt
      361 ttaactccaa tagaatttaa tttctttgac cactctatca cttcgttatt attaatatat
      421 gggtctttct cacccaaaat attaactata acagtatttg agtctcgtgc cttttcaata
      481 ttttgcatag gcgaatatga ctttatataa gcctttactt cagggtctct aatatctccc
      541 cactctgcta tttcggtctt agaaagagga tcatttggat tctgaagtgt atcataagga
      601 tttataaatg gcgaaaataa gagaatgctt tgcaataaat ttttttcctc gttcaacacc
      661 gcaccagcaa ttattccacc tgcactagaa gttattaaac ctaatcgctt actgtcaatt
      721 acatcatttt cccttaaata atttactccc tcaataaaat ctctgataga attccatttg
      781 tttaacgcct ttcctgagcg ataccattca ccacccaaat agcctccacc tcttacatga
      841 actatagcat aaataaaacc tgcatctatt atagataaca taatttcatc taaatcagaa
      901 ttatcattct taccataagc cccatagaca cttagaatac atttttttct tcttgggagc
      961 tcatccgtat cttcactttt ccaaaataaa gaaatcggta tgcttacatc ataactgtct
     1021 tttttagtcc aaatcacctt agaaaaatat ttagtattat tcgattttat gatgggtctt
     1081 tcaaattcag tttttaatgt attttctatt aaatcaaaac taagtatttt ttcgtaaaaa
     1141 gttctcctct ctaaaaacag aagaacacga tcagaaaatg aattttcata aagtgttgtc
     1201 ttttcatcaa atgttatctt attaacactc aactccctca aactattatt tttaaatgta
     1261 gcaagataaa agacggaatt cgctgcgttt gaacagtcta aaaggatata acgtcctata
     1321 cagtgaactc ttctagccct atcttgatat ggtatagtaa tagaaactct gtctcccgaa
     1381 gaagtttccc ttagaattag ttgatctttc ttttcttcag ttgaagagag cccaagaaag
     1441 tactgtgctt tttctgtact aaatagagcg atatctctag gtgttggggc taccgtttct
     1501 gtgtaagagt gtctaacaaa acccgtccgg tcgaaactgt atagaaaaat cctgcctttc
     1561 tgaaagtcta ctgactttac aaaacaatta ttgctatcaa tgtggactat ttttaatcga
     1621 aaagagcatt cgttttcttc aaacagttcc tcttctgtaa agctatcaaa agatttatag
     1681 aataacttac ttggcctccc gtactctttg gagcgagtat acataacacc gaatttaccc
     1741 aaatagaacg aactttctac tgaaatatct tcaatgataa ataactcttc catagtatat
     1801 ttttttattc caattaaatt agtgctacgc agtgaggata caaccaaaac tatataactc
     1861 tcatcagatg aaatcctaac atcctgtaag atactatcat ctggcaaagt atatttttcc
     1921 acatcaaaga caattttaag tgaatttgaa ttgtctaaac tggaagaact aaccttagga
     1981 atccagtcat tatcttcgac ataccattcc tttattacac cagtattggg tatactccaa
     2041 ttatcaaatt ggtaccaata tcgccctctc ctaaatatca aagaattcca tttttttaat
     2101 tcctgaaatg atgaagagat agacctctta tagtgtgttt tttcctgtat tgtatttaaa
     2161 aatatttcat tactctgatt cacaagtatg accccttaat aatggtatct aaatattata
     2221 tttgaggaag aatcgtcaat ttattatcca ttattgatac caatccaatt gcaacacccg
     2281 caaatcccga agcaatatct gttgttatct ttaaaccatt atctcccgca ataacaaatc
     2341 cttcttcaat tacacacaaa tatctataaa gttgttcaat taatttcttt tgtcctgaaa
     2401 agttatcatc gatatcacta tatatattat tagcaacttc aagaccacaa aatccgttaa
     2461 ataaacctgg taatacacaa aaaactacat cagttgccct ctctaaagaa gttaaatatt
     2521 ttaagtattt gcttgacaag atttctttat ttctattaat aagtaaaagc aggccagcac
     2581 ttccagttgc tagatatggt agtaatctat gaccttggct gtactgcaat gaattattac
     2641 tatctacttt ataagcaact aattctttat ctacagccaa ttctagacca tttttataga
     2701 tactttcacc agttaattta taagcttcac cgaagagcca agctacccct gcgtgaccat
     2761 atagtaatcc accaaaattc tcataaggat cattactctg aacatcacta gcgccaactt
     2821 tacaaaaagt ttctggattt tctatataat ttaaagtata ttctctaagc ctaattagta
     2881 tttcttctcc tagtttatta tcaatttccc ctttactaag aaaatacagt ccaaccagta
     2941 aaattccagc ctgcccacta tataaatttt tattttgtga attctcaaat atctctataa
     3001 aatgagttgt aaaaagttca actgcccgat ctatctcccc aaattcataa atgagccaga
     3061 ttgtaccaat tttaccatca aaaagaccag aaagggacga tttcttaaaa ttatttactg
     3121 cctcattaat aacctgtgtt cgaatctcat aatagtcatc aaacttgaaa tttttacttt
     3181 cttagctagt tgttgataac tccaaaggat agctaaatct gaaaacgcaa ttccttgatt
     3241 aaaattcaga ccataataat gaactgggaa gaatcttgat tgaaattctt tacgccactg
     3301 tccataagtt agcgtaaacc ctctcaataa ttttataata aaatcttgta tatcttgctc
     3361 actctcgata gttctaatct catgcatggg ttttaaaact tttttcctgg aaatattctc
     3421 aatctgtgga catttagaat ctagatatga caataaactt tctacataat ctatatgttc
     3481 tcttgtataa cccaaagact caaatagttt ttttccttct atcctggttt gacttacata
     3541 gttgtatgtc aaatccgatg tagttactag tagcatgtat aaataatgag ctatttgtct
     3601 aataccatac caatctatct cactgggaag tgtttctcgc catgctctaa aaccaggggc
     3661 tgcaacttta tgtacaactt tttcatcatt cgaaaagaca gcctgttccc agtctattat
     3721 actaatctca tcttcatcct taaccaagat attttctaaa tgtaaatctt gatgatatac
     3781 attttcagaa tgaaacttat tcgttaaatc gatgagtttt tctactatct ttgaaactct
     3841 caatagataa tctttggtct tatcaacaac ttcatataaa ggaaaattat tggtaaccca
     3901 tctatttagt ggaacgccct tcatatgttc aattcctaag aaggtgtgct cccagatctt
     3961 accgtaccag tatattttag gcatctcact ccattcattt agaattttta gtgctttgca
     4021 ctccgaagct aatctctctg aagaataagt accatcaaat cctagacctg tatacggtct
     4081 agcctctttt aaaattattt ttttcccatc ttcttttagc ctagcattat atatcccacc
     4141 actgtttgaa aatctaattg cattatctat aataaaggga aagtctccct gttttttatc
     4201 tttcttgtca agccatttat tcaaaaagtc agggggcact ataccttttg gaattttaaa
     4261 tactggtaaa cgttcatctt taacaacttc atcgccaaca attaattcat caatagcaac
     4321 cttcttttca tcatcccttg acggcctaaa cacaccatac ctcagatata ttggtgcttc
     4381 atcccaacgt ttatcgctta aaatatatgg cccattatat tgctttaagg cactttctaa
     4441 cctttgcaaa accgactcta attcattttg atttggataa catgtaataa atttaccaga
     4501 aaatcctcga ctaaccaatt tcccgtttcg catgataaat ttgtcttctg tactaagatg
     4561 tttaaatgga attcgcattt catggcaaat ttttgctaca tcttgtaaca attcatgtga
     4621 actgttatac tctgaactaa tgtgtatttt ccacccttgt ctttcaacaa attttccaat
     4681 agggtattga taaacccact catcattatt cattacttcg tgccaattaa aaggcagact
     4741 tacttggtac tttatgctag tatctgtact ataatcatta ttagtgaaaa agaaaggatg
     4801 ctccaaattg aaattataat ccataacaaa atctccaaga aattttatca aacttaatat
     4861 atctatagct agacagactt atttaaataa aaagggagaa tcctttggat tctccccata
     4921 taagcactaa cattccaacg tgcacatatt ggaacgacat ccataactcc agagaatctc
     4981 taaagtttac aatttaaatg aattaacaat tttcccaact aaaagcactc cagttaccgc
     5041 aacggtttgt actgaatgta ctaaatcgca ttccatcaac tttatctgtt tcgtcaactt
     5101 gaacagatac taattgaaga tttaatactt cttctgccat agctaactcc tcctatttaa
     5161 atttttagga ttaagtgctt tatccacctt cattatactc tctccagcag taaaatgcaa
     5221 gcaatgatac aatgttgtca catagaaaat aatgtttccg taacttttca aagtaacttc
     5281 catctctctc ccaaaactgg aagttagttt tagaagttac ctaaaaatca ggttacctat
     5341 tttaaaaaag cagcaaacta taaactagta ggctccacac caaatgtagc cccatactgc
     5401 cccataagtc caatttgtag cgtacaagcc ctaaaaacat ccccagcgat acatacaaac
     5461 accaagctat aatggttcct ggatgatgtg ctaaggcaaa taaaacactt gtcaaagcaa
     5521 ctcgaatatc taattttcta accaagttcc ataaaatttc tctatacaga aattcttcaa
     5581 ccatactcgc attgattaaa aacaataaaa atgaaaacca aggaacttga tgttgaagtc
     5641 caattaagtt tgcttgattc gtgctttctt gcgcatggat taggctaaaa catagactta
     5701 taatcagtag gctaacgaat ccaataccaa gccatttcat cctagatttc atatttacct
     5761 tatgagcttg tttgcgttgg ccatacatcc ataaaaaaga aatgagtgac gaaccataga
     5821 gaatctgtag tatagttaac tcaccgatac aaagaaattt caataagtat agagatacca
     5881 ataggacatt tacttgttgg aatatataaa ctggaattat tcttttcata gttacctccg
     5941 aaataaatct tcataatcta aatctaatac ctgcacaatc ctttctaccc atggactttg
     6001 aggcattcat tgttccatct tctagtggcg aatcttttga tacaaacgat tcaattcact
     6061 tggatagtga aactctcccg caaacatttt tctggttaac tcaatccagc tgatatttct
     6121 ttcagccaaa ataatggaca agttctccca aaatcgttca gccatattgc ttctccttta
     6181 gttatataaa taatgtgttt gtgccatgta aatcaattgt ttcgtatctc ttggcaatag
     6241 agctctagcc tcttccaaat tcagacttgg ataaacccgc ttatttgaaa ccacaagagg
     6301 aagtctgatg gttagttcag gattttttaa aattatctca acgaaatccg ttaatcttag
     6361 attgtcacgg ttcttaaatc gtaataaatt gggagataaa aactcaaaac aatctgaaga
     6421 atagctcatc atctcaatta atttgtcctt tgtcatttca gaaactgaat gacaagatac
     6481 ctcgatgcca tagttttgga agaagtctaa aagaagttga tttctttggc tatttttact
     6541 tagatagaga tcaatcatgg gagacctccc aaagattcgg ttccatttga tattctgaca
     6601 cgattaagga atctaataaa tttgcgaagt taatcggttt cttgtcttca tcataagctt
     6661 ttacagttac ttgggttgta agtattccct cttttccctc ggctcgatag ccttgtccat
     6721 ataaaacaaa aacgagattt tgatgatcat ctacaaaggc atcaacccca ttctttatgt
     6781 cttgactttc aaggaattcc ataacgtttt gaagatagga ttcgtaaaat agtgggtagt
     6841 tatgtttttt atggtaatca tctaaaaatg tcacttcaaa ctcacatgga gagtaatttt
     6901 gactttgaac agcctaaaag tgccatcaaa tttgaattgg aataaatcaa ataaatagcc
     6961 ccatcctcat caatccaacc tttgctcaaa gacaactcca accgatcttt taaaactgag
     7021 taaaccacct taacctccag tttcatattc ttataccgtt cactctcaaa taaaagtttg
     7081 gggagcttat aataacgctc tgatgtctga tattaattag cggtaatacg cttcattatt
     7141 gtccctccaa gactaaaatt ccaacatttc caaattcatc aaatcggatt aaacctactt
     7201 gttccatttc atcaactaac tgagttgctt ttacaatatc aactcccatg atagtcatga
     7261 gatgactctt cacgaattga cgtgatgact gtccttcctt ttgcataatt acctccgaaa
     7321 cacaaaaaaa gggtagacaa tctagtgtct acccccgaaa gtttattaaa acaaaaatcc
     7381 tgccaaagaa tttttggtag ggtttttggt aggaaactaa attaatttat cagtttctaa
     7441 aatgtgttca cgattctaaa aggctgatac tatagtattc cgaattctaa ttggtatatg
     7501 cctcttattt aagagtaact gaagctccag cttcttccaa tttagctttg atttcttcag
     7561 cttctgcagt tgcaacgcct tctttaacaa gtgctggtgc accgtcaaca agttctttag
     7621 cttctttaag accaagacca gtgatttcac gtacaacttt gataacgcca acttttttgt
     7681 cgcctgcaga tgtcaattca acgtcgaatg aatctttagc agcaccagca tcagcagcat
     7741 cagctgcagc aacagctaca ggagcagctg cagttacacc aaattcttct tcgatagctt
     7801 ttacaaggtc gttcaattca aggattgaag cttctttaat ttcagcaata atgttttcaa
     7861 tgttcaatgc cattgttatt tcctccaaat aagttttaaa ttttataata gtttttttcg
     7921 tagctaggct acgctatgta gcttaagatt aagccgcgtc ttctttgctt tctgcaaccg
     7981 ctttgactgc aagagcaacg ttgcgcactg gcgcttgaag tacagaaagg agcatagaaa
     8041 gaagtccttc gcggtttgga agagttgcaa gtgcaagaat ctcttcttta gatgcgacag
     8101 cgccttcgat tgcaccacct ttaatttcaa gtgcttcagc gtttttagaa aagtcgttca
     8161 agattttcgc tggtgcgata acatcttcat tagaaaatgc tactgcagat ggtccaacaa
     8221 atacagatgc aagatcttca agaccagctt tttcagctgc acgacgcaag attgagtttt
     8281 taataacttt atactcaact tcgcttccac gaagctcacg acgaagaact gtatcttgct
     8341 caactgtcaa accacgagcg tctacaacga cgatagatgc agcagctttc atttttccag
     8401 ctactacgtc aactagttcc gcttttttag caataattgc ttcactcatt agtgtgttca
     8461 cctccgtaat tattttgctt ggggaatttt tcaaaaagaa aaacgcgccc aaacctagac
     8521 acgaaagtac aatacgcttc tttttacatg atacgtcttg tcctcggtag gatatttatg
     8581 agtcgagctc ccctactgtc ttaggcagtt tttttaaacc gtatataagt atagcatagt
     8641 caaaaaaaga atgcaagatt tttgcaaact ttttttaaaa tttttcgtga tttttctttt
     8701 aaagttctac tgtcaggact tgaccttgct taacaacctg ttctccggcg atataaacat
     8761 catctacatc attagattta actgcataaa ccaggtgaga cagcatattt tcctgaggtt
     8821 ggagatgaat tttcccttgt ggttgaatga ccagaaaatc tgcttgcttg ccgacttcca
     8881 gacttcctat ctgattttcc attccaaggg ccttagcccc ttcgattgtc agtaccttga
     8941 gagctgtttc gattggaaac tggctggcat ccccactttt catcttctga agaagagctg
     9001 cagtccttcc ttcctcaaac atatctagat tgttattgga agcaaccgag tcagtcgcaa
     9061 ttccgactgc tactcccgct ttttggagct ggataattgg agcaattcct gatgccagtt
     9121 tgaggttact gataggattg tgggcgatag ccacttgaga agatgccaag cgttcaattt
     9181 ctctctcgtt taattcgacc ccgtgagcaa atacggacgg atgatctaaa taacccagtt
     9241 cttcaagaaa agcaaggggg cgtttgccgt atcgtttgag gataattcct gactcctcct
     9301 tggtctccgc cacatggaca tggagcggaa tatttagctc ttttgccatt tccaaactcg
     9361 cttccagcaa gtctctactg cagctatacg gagaatgagg tgctaccata accttgaaat
     9421 ttggattttt atattttaag atttcgtcta tgatggatcg agttctgctt atagtctcag
     9481 cagttgtttc tgtctctgaa gaaaagagag tcggagaaaa ataacaacgc atcttggaag
     9541 ttttcaccac ctgataaatt tgctgaatat ccacaccatt gggattatac atatcgttaa
     9601 aggttgttgt tcctgactgg agcatctctg tcagggcttc tttgaccgca ttggtagtca
     9661 tgtcgggagt aaactcagat tctgctggcc agatatagtc attgagccat tcatggagat
     9721 tgctgtcatc tcggatccct ctcagacctg tcattgcaga atgggtgtga caattgacca
     9781 aaccaggcat aatccaagct ccctgatagt ctacaatctg ctcagcttgt tctaaaaacg
     9841 ctggcttatc ttgaccgaca tagacgattt gagaatcctt gactgctaag attccatcaa
     9901 gataaacatg gaaattttga tcacaagtca cgatatttac atgctgaaag actttcatta
     9961 taggctcctt ttctaaaaga caagttgtac tctcttcaaa ccacttcaga ttcactttgc
    10021 cgtaggtgtg gttactgact tcgtcagttc tatctgcaac ctcaaaacag tgttttgaac
    10081 tgacttcgtc agtcttatct acaacctcaa agctgtgctt tgagcaacct acggctagct
    10141 tcctagtttg ctctttgatt ttcattgagt attacagtga acaatttttc tagctattgt
    10201 aacaaaaaag tcactcgaag gcaacttttt tcgtccataa actttcaaaa gagaatggct
    10261 tattcagaac taaaagccgc agctttttgc atttggtaat acttaccctt tctatccatg
    10321 agttcttgat ggttaccata ttcaacaata tcaccatcta ctaagacaag aattaaatcc
    10381 gcatcctgaa tggttgacaa acggtgagca atgatgaagc ttgtgcggcc cttcatgagt
    10441 tttgcaaagg catcctgtac cagcacttct gtccgtgtat caatggaaga agttgcctcg
    10501 tctaagataa gaatctttgg aatagccaga aagactcggg ctatggtcaa gagctgagct
    10561 tggccgacag agagagattc tccagcattt tccaacttgg tatcgtatcc ctgtggcaac
    10621 tgttgaatga aaaagtctgc attagctgct ttggcagcag caattacttg ctctcgactg
    10681 gcttcaggat tgccaaaggc aatattatca tgaatgatcc cttgtgtgag ccaggtttct
    10741 tgaagcacca taccaaactg ctgtctcaat gatactcgtg tataatcata aatggattgc
    10801 ccatccagca agatatctcc cgagctaatg ggataaaaac gcataaggag attgataaga
    10861 gttgattttc cagcacctgt cggaccaacg atggctacct tactaccagc tggaatatcg
    10921 atagacaagt ccttaatcaa aattttttca ggatggtagc caaaagagac atgtttaaag
    10981 gaaatagctc ccttaacttg gtcactggtc aagacttcct tacctgtttc agccacttca
    11041 gggctatcta agactccata gatacgctct acgcaagcca gagcactttg caactcagct
    11101 agcactgaag aaatatcgtt aaagggcttg gtgtattgct gaacatagtt caaaaaagtc
    11161 actaaacgac cgacagtcaa ggttgaaccc atcatgatac gataagctcc tactccagct
    11221 aaaagggcat aaatgagtgc atttacaaag cgagtcgaag gattgaccgt tgaagaataa
    11281 aagatggctg actgagaata gcctgagtag ttgtcatgag cctcacgcaa tctttggata
    11341 aattctgttt gagcattgaa ggactggatt atagtctgct ggctaagcga ttcttcaatc
    11401 aactgagtct gaattcccct cgtctctgtt tgcttctgga agagatgata ggatctcttg
    11461 gcaataaagc gtgaaatcac catggacagt ggcgtcaaca gcaagactaa gagagtcatg
    11521 aggagatgaa tttggagcat ggctagaata ctaaccaaaa tcatcaaaac accaatgaaa
    11581 aattggttaa aaatcatggt caagccagct gccaactgtt cgatatccgt ggttacacga
    11641 ctgaccatct ctccattgcc ttgccgatcc gcaaaagcaa tcggtaaccg atggagttta
    11701 tggatgattc gctctcgtaa atctctggta taagagaaga ttagacgatt atagaggaga
    11761 ggattggccc attgtaccag agtatttcct attactacca agagcatctg gagaaaaatc
    11821 tgccaaaaaa ctggtgatga accagccact aggacttggt caatgacctg cccaatcaga
    11881 ataggtaggt aaattgataa gccaacttgg gcaatagttc ctagaaaggc taggaaaagg
    11941 aggaagggat ggtttgccaa atctacgact aaacgtttga gcgtctggtt tacagtttgt
    12001 cgtttcattc tagtcctcct ttccatgttg ggatgcattg atttcacgat agacttgact
    12061 ggatttcatc aagtcatcgt gcttgccaac agctagcaac tcaccttttt ccaagaggag
    12121 aatctggtcc gccatctgta aagtcgaggt tcgttgagag atcaaaatta agctcatgtt
    12181 tggaaaattt tctctaatag ctttcaagag cttggactct gtaatggtgt ccagtgctga
    12241 ggtcgcatca tctaggatga gaaacggagc ctggcgcaag actgctcgtg cgatagacag
    12301 cctttgtttt tgtccacctg agaaatttcg ccctcctgct tcaactagag catccaagag
    12361 tccttcctta tcactgacaa aatccttagc ttgagcaatt tccaaggctt gccagagttc
    12421 ttgatcagtc acttcttgat ttaaacctaa agtcaagttg gaacgaatag ttcccttaaa
    12481 gagttcgacc ttttgaggta cataggcaat ccaagaccgc cactgctcca aattaagagg
    12541 actacgtcca ttttgataaa ggtcaatgtt ccccttgtct actggataaa gtccaagtaa
    12601 gagttgcacc aagcttgatt taccagaacc agttcccccg atgataccta gaatttgtcc
    12661 ttgagtcata tcaaaggaaa tgtatctcag agaaggctgg gccgcatcag gataggtaaa
    12721 ggtcaattct tggacttgta aaaccttatc tctggtagct tgcttttgtt ctaactctga
    12781 atggatatcc tctggagcct caacaaagac ttcctcgatt cgcttggctg agatatagga
    12841 ctggttgaga gaatttatca acatggctag cttgaccaat tccaccaaaa tctgtaagag
    12901 gtaattgata agagcaatga gagcaccttg actgagcact cctccttgaa ttgaaatata
    12961 gccttgccag ataataacga gaagagttcc attgacaatc agataggtca gaggtgttaa
    13021 taaactagac cagaaacctg tcttttcttg taatctagca taaacttggt taagggtttg
    13081 aaaaatctgt aactctcgtt tttcttgacc aaaagcacga ataacccgca tcccttgcaa
    13141 ttgctggcgc gtttcctgaa ccagttggtc cgttttcttt ctgagactac tgtagagagg
    13201 attgaccaat cgagataacc ctacaatgac aatggtcaaa atggcaacca tgactaagaa
    13261 ccagaaagtc aactcagttg agattcgata agccataaaa atggcaccaa aaacgataat
    13321 gggcgctcgc aaaaagagac gcaggaattg attgatacca gtctgaatct ggtaagtatc
    13381 cgaagtcaag cgagtgacca aactagatgt tgtcagacgg tctctgctgt ccttgggcaa
    13441 ggaaagaata tgacgataaa gatcgtttgt caattcctta gcaaaaccta ctgctgcctt
    13501 tgctgagtaa aattgagcta tcaaggccac taaaacgcca attactgcaa agataaggag
    13561 caggccaatc tgcatccaga gatgaccttg atctccctga ggtaaagatt ggtcaacaat
    13621 cccagcaatc accatgggaa ccaagagctc aaaaacagct tctaacagct tgaacaaggg
    13681 ggctaaaatt gattccttga tgtagggttt gaagtaagat aataggtgtt tcataaatcc
    13741 cttctattca tattctagaa atgaagaaag tgggaagccc cactctctgt tttatttgtt
    13801 taagtaaggc aatagatagc catatcctgc tttttccatc tcatccttgg ccacaaagcg
    13861 taaagaagca gaattgatac agtaacggag gccgcctaac tcccgcggtc catctgtgaa
    13921 aacatgaccc aagtgagcac tgcctgaacg agaacgaact tcaattcgct ccattccatg
    13981 gctcagatcc ttgtaataat gaatcaactc tttggaaatc ggacggctaa aacttggcca
    14041 accacaacct gaagcaaact tatccttggc aaaaaagagt ggctcacctg tcgtaatatc
    14101 tacataaatc ccctcttcaa aggtttggtc ataggcattg gtaaatggag cctctgtagc
    14161 agcttcttgt gtgacacgat aagactcttc agatagactg gccttcaaca cctcttgact
    14221 aggcttttca tagtttgctg catcaatcaa tggcttatca gcatcggtca catcgatatg
    14281 acagtaacct gaaggattct tcctgagata gtcttggtgg tagtcttcag ccagaatgta
    14341 gtggcgtaat tgctccactt ctactgcaat ctttcgaccc agcatgcgtt cctgctcctg
    14401 taccactgtg tagatagctg gcaaatctgc ttcatcctga taataaatcc cagttcgata
    14461 ttggcgacca cggtcattcc cttgttgatt gatagataga ggatcgataa ctcggaaata
    14521 ataaagtaaa atctctctga gtgacacttc cttctcatcg taaatcactt ggaccgtttc
    14581 tgcatggtct gtttccttga tcaactggta attggtcgtt tcgacttgac cattagcgta
    14641 gccaacactg gtttctagca ctccagaaat gcgtgaaaaa tattcctcta ggccccaaaa
    14701 acaaccacct gctagataaa tttctgccat ctttatttct cctttatcac gtttttaact
    14761 aatactcttc gaaaatctct tcaaaccacg tcagcgtcac cttaccgtat atatgttact
    14821 gacttcgtca gttctatctg caacctcaaa acagtgtctt gagctgactt cgtcagttct
    14881 atccacaacc tcaaaacact gttttgagca gcctgcggct agcttcctag tttgctcttt
    14941 gattttcatt gagtataaac ttcttttcac aaaaaggata tgaaaccctc tggtcaagag
    15001 tttccccatc ctatcttcta ttctttattt tgcttctaca cggacacctt gggtatcaac
    15061 tctcaagtca tgcagttttc ctttgaaagg ttgcttttcc aattctgcct taattgttgg
    15121 catcttgtca tgagaagcca gaaccataac tgtcggccca gcaccagaaa ggtaggttgc
    15181 ataggcccca ttttctttgg tcacttgctt aatcatcgca aattctctta ccaagtcctg
    15241 acgatagcgc tcatggaaga ggtctccctc gattgcttgc ccagcggtca ccatgtctcc
    15301 tgccaacaag gcagcaaccg ctacattggc gatagaactt gcagcaacag cttccttata
    15361 agacaatttt ttaggcaaga cactacggct gtctcgagta cgtaattcat agtttggaat
    15421 gtaagctaga aaatcacact ctggaaagtc tgctacgata gcagagactt gcccttcaac
    15481 agaacttgca ataacgagat taccataaat ggctggagcc acattgtcag gatgcccttc
    15541 aatcttggtc gctaactgca atttttcatg gtctgataag ttgagttgac ccagttggtt
    15601 ggctagttca atcccagcaa cgataaccga gctggaagaa cccaaaccgc gcgccaaagg
    15661 gacatcactg gtcattttca agcgtcttgg ttgcaagtct ggtacaattt gcaaagcgat
    15721 tttgagcaag agattacgct catcatgtgg aatccatttg ccaatctggt gttcaatcag
    15781 ccactcatct cgttcttcgc agacctcaat ttgaagatac ttggttacag ctacaccgac
    15841 cgagtcaaaa cctggcccga tattggcact ggttgcaggt acaataatct tcatcttatt
    15901 ctcctagcac cttgaaggta ttcaagaggt cgaattctga aaccttcttc aattcagcta
    15961 agacattttc aagctgggct ttattaatct tgtgtgtgat gataacgaca cgcgccttgt
    16021 caccctcttt gccatcttga aggatttgct taaaggaaat atcttgagca ttgaagattt
    16081 cagccaactt caagacctga ccttttgagt ctagagccaa gattgagaaa tagtagtttg
    16141 ctttgacatc ttcaggattt gccaagacca agtcacggct atattcgttg aagtctttgc
    16201 caatagtacc atcattcaaa cgacgaacga tacggacaat atcagctaca acacttgttg
    16261 cagttggttt ttgaccagca cctggtccgt agtacataga ctcaccaata ccgatagatt
    16321 ctacaaagac agcgttcatt acgccattca cactagcaag tgggtgcgct ttaggtagga
    16381 aggttggagt cacttctgca gcaatacctg aagaagtttc ctcaatagaa ccaaccaatt
    16441 tcactacgta accaagctct tgagctacag ctacgtcttc tggtgtgata ttgcggattc
    16501 ccttgtgggc tacatcatca aaggcaatct tcatgccaaa ggcaaattgg ctcaaaataa
    16561 ccatcttgta ggctgcatca atcccatcta cgtcattcgt cggatcgctt tctgcaaatc
    16621 ctagacgttg tgcttccgca agagcatcat cgtaagacca gccttcttcc accatcttgg
    16681 tcaccatgaa gttggaagtt ccgttgacta ctccaagcac gcgcgtaatt ttatcagaag
    16741 ccaaggaatt tgctaaagta cgaagaattg gaatcccacc agcaactgct gcttcgtagt
    16801 aaagtgctac cttgttagct tgagcgattt ctagcaattc tgcgccatgg acagctaaaa
    16861 ggtccttgtt agcagtaaca acgtgttttc cagcttccaa ggcacgagtg ataaaggttt
    16921 tagcaggctc aatacgcccc atcaattcca ctacgatagt aatatcctgg tctgataaaa
    16981 tatcatccac attggttaca aagttaaagt cattccctgc tgcaagcaag cgattttttt
    17041 catcttcatc cttgaccaat accttagcaa ctttgatatc tgaatgtgct gattgattga
    17101 tttttcctcc attttccttt aggaggaaag gcacaccact tgcaacggta ccaaatccta
    17161 gtaaagcaat tttaactgtc atctttatct cctcgaaatt ttctaatata gccattataa
    17221 cagaattttg tgaaaattcc tattatagta aatcactatt tcagtataaa aagaaaaaac
    17281 gaatcagacg attcgctctt cttaaaatct gaaaatagct ttccagaaag gattagccga
    17341 ttttttgcag attgagcact gcatcgtgac tcatcaagac ttgaccatac tcttgtaaga
    17401 ctgagcgact gatatcacta tcgtctgcaa actcgcgcat acgggccaac agccaagctg
    17461 gatatgggct tggatgattt tcaatatcca ctaaaatggt caaataatag cgctcgttca
    17521 ttttgtagag ttcagaagtt tccatttcaa aagtcactgt cttggcaaaa actaccaagt
    17581 cagccaactt agcaaaagaa aggatgtagt agatgtaagg ttctttctta ctctcagctt
    17641 cttgttcagc ctgctcttgc tcttcttcct tggcttcaac ttgctcaaga gattgaatgg
    17701 cttcgatatc atccttggtt ttgtctgcga tgcttttttc cagggttttg ataaattcat
    17761 ctggagacat ttgagccaat tcttccatat ctggcaaatc cgataagtct tcaaaatcta
    17821 gattttggtc aatctttgac ttggtcacaa agacatctac cttatcaggt tttggagtca
    17881 cacggaagct caacatgcct gtatccagaa agctatcagg catctctagc tcatccaaga
    17941 tagcataaaa gaactcttct gttttttctt gaggaacgag aaagtcagca atctccattc
    18001 cacgatccat caaatcctct aaagacatcg tgatttttaa agttgtatca ctaatttgtt
    18061 tcattttcat tgctagtaac ctcatacttt cagttctatc tattatacta gatttttacg
    18121 attttatcaa aagaaggctc ctctatacgg atagattttc cctagggtct ttctatagga
    18181 gactccaaaa gaaaatttct gcagacagat agaaaaagcc ttcaaaatca gctcttagcc
    18241 gattttgaag accttataca tcagaatact tataatttaa aggttgctac accaaggata
    18301 gaacgattta agtttctgag aatttgaaga ctttgctcaa atttcttata acgagtcact
    18361 ccgtactctt caacaagaag gactgtatct ctttccaaaa gagatgatac atcctgtaaa
    18421 tctacaaaat gcattccttt taaagcttct tgactctgtt tcaatttatc taggatagct
    18481 ttatttgagc taacgatggt caattcctgt ccagtatttt tgtatgacaa aacatctgct
    18541 aggttagcaa ttgttgtaat ctctgttaca aaatcaattt gatactgaga aaaatcacct
    18601 actctattga ttgttggatt aaagagataa actaacacat ttcccatcac aaccaaaatc
    18661 acacaaacca ctccaataac aactaaacga agaatcagat ttttcacatt taagccaagc
    18721 gctgtttcac catttgcgtt caattcttta gagttgatgg tttccagttt ttcaattttc
    18781 acatttgcat aggcatgttt aaatttctca atcaacccat caattttttt ctctaacaag
    18841 tcattggcat ctttacttga tgtcaaaatt ttcacaccaa cccctgcatc gtcaatcata
    18901 tagtagacgg tcaatttttt ccaccaatag tcattcgttg aatttttcaa ggttgtttct
    18961 gtcgtgtcta attcactggc aatttttttc aactcactgg gttctacatc attgaaaaga
    19021 taagctccat tcaaattacc atcaatcaat ttcccataaa aatcactata accaccaatt
    19081 tgatgattca aaatcgtttt ggccgactct tctggaggag tgattttata gataagataa
    19141 gttgaataac ttgttgtatc tttgacagtg tttttattcc taactgcttt aattgtaaat
    19201 ggtacagcaa tgagagcaaa taaagcgatg agagctaaaa tatttgcttt tcgcttttta
    19261 taaagatttg caaacaaatc agctactgaa taatgttcaa acatgatttt tttctccttt
    19321 gtttagtaga tactagtttt cctttgtaag catttttgct acaaatataa tcacaagaac
    19381 aattccccag aattgcattg taaataaatt gaagaaactt tctgaaaagc tgcttcttgg
    19441 cataaagaat agattattca agatgagtag ggataaagca aataggattg tccttgagcg
    19501 ataggctact tgcagcatgg ctataaataa tacgccgagt aagaaactaa gcagaaagac
    19561 tccaatcata ccatagtcgg tatacaactc catgatataa ctacttccga taccatgccc
    19621 tttcaagtat tccttgttca agacaagata ggatagattg tgggcataac tattactatc
    19681 aatagctagt tccacactat tggttgtatg ttcaaaggct tttcctccga aaatggctcc
    19741 caaactcccc cttgcaaaat aatcaagaac aggaccaaaa gtaaaattac ggaaatctcg
    19801 gtaagggagg ctactgttaa atagaaaacc tcgagccaga acaccaaaac tagtcccttg
    19861 tttatagata aagtcaagta agatatccca gaaacctgta tgggaaactt ggacattatc
    19921 ccgtacataa ttgagtactc ccatcgctaa catgagaata ggagaaccta caaaaatcgc
    19981 taacttttct ttaaacccaa tccattttcc tttttcagct tgctcccgca taaagtaata
    20041 aacaaaagca aataaaatac ttaaaataaa gggatttcgt gtcccaattg ccaaatgaat
    20101 agtgttagct gcaataaagg agacaagcac tgctgtggcc tgcaatttct ttggcttggt
    20161 tgccagatac atacacattg catagaccgt aaaggtagac aaaatgtagg taaaataagg
    20221 cagtttactt tcaaaatttg catagtaggc atagtaggaa gtctgcaaac gatacaagag
    20281 ccgttcaaat aaccgaatga aatagaaagg ataagttaga agaaaaactc ctagtgatac
    20341 aaagcgtaac cgcttgatat aaacctcttt tagagaattt cctatatttg ctacttttat
    20401 tttcttccta gctatgaagt aacgagccag gacgcctcct gttgtcaagc ccagaatcga
    20461 aaccatgaca actataaagg caaaacgata ggctattgga tgataggtat ccaaagcacc
    20521 atccctaaaa taatcaatgg tcggtcttga taccagaaat acaaaaatgg ttaaatagaa
    20581 aataaaatgg attaagtaat acttgatatc attccaacaa gcaatcaagc tactaaccaa
    20641 caagaacaat aaagtagaaa gtaagctaac attattatta ttaaacagat acacaattcc
    20701 acttactagc gtcaaggcat aactgactat ggtcaaacta aataataatc gtttcccatc
    20761 aatcacttgg tcacccccgt tctaatgtaa ttttttagat ttttcaatat ttttcagtaa
    20821 taagaatcgg tataaggaaa tatttatgaa tagggccaaa gcactaattc ttctcccctt
    20881 acggaaaatt ggattcctag aaatagcaaa ggcatggcct tttaaaaaac gatgaatctg
    20941 agaataggct tcaaactgtt tatactgatc atctagcaac atcttatcca gaataaagaa
    21001 gtgggcatag gccaatctga aaaaagcgac ctctttcaag tcaggatagt ttttcacaac
    21061 ttcattataa aacttttggt agatatcaat ataggctaaa tccttctctg catagggttt
    21121 ggtcgtaata ctatcccctc tatggaaata gtaataatag ggtttagtat taaccacata
    21181 cttcttggcc aacttgatta aatcaaaatg gtaataggca tcttcgtaaa tcaacccctt
    21241 aggaaaggat aggtcagttg caatctgtct cttgattagc ttattgcaaa tcgtcccagg
    21301 tattttttca cctatgaggt attcctttag aaatgtttga gaatcacaga caaaatagtc
    21361 atcctgattg gctgactgtg ggctttcatc attagcatag acattcatga caccacagct
    21421 cgaaacatcc gcatcttctt gaactaattg ctcatataag ctctgaatca tttctggatg
    21481 gatataatca tctgagtcaa taaaaatcag ataatccccg tgagcctgct tcatcccatc
    21541 atttcgtgct tgcgacaatc cttcgttctt tttatgaagc actgacaccc tgtcatcttg
    21601 ttcagcgatt gaatcacaca agcgaccact ttcatctgtt gcaccatcat caacaagaat
    21661 aatttccaga ttttgatagg tctgcttctg aatggaagct atcgattttt ctaggtactg
    21721 cgccacatta tagactggca caatcacact aattaatgca gtttccatgc tactcctcta
    21781 atagtttttc tacttgttcg atttgttttg taattgtaaa ttgttgaatg aattggctag
    21841 cctcatcgac atcaaagttt gaggcagaag tcatgtaatt agtaatcgcc tgagctgcct
    21901 cttgattgct ctcaatgatt tgtccaaatc gtccttcttg ggataattcc tcagcccctc
    21961 caacgtccgt agagataaaa gggagtccca gactcaaggc ctccacatac actccaggaa
    22021 aaccttcttg tttagacata gacaagagaa ctttcgtctg agataaatac tgataaggat
    22081 ttttttgata accaaggaaa tgtacatagt cctcaatctc atactctttg actcgttttt
    22141 tcagttcctc ttccatatca ccagccccga taaaatagag atgatagttt tttccctctt
    22201 ggtgtaataa tcgtatcact tccactacac ggtcagaacc cttattttcc tcaatccgtc
    22261 cgatagtaca gatactttga ggagcaatct cgatatcgat cttctcttga gatttttcta
    22321 gaatagtctg aaaatcatat ccattgtaga ttgtctgtaa tttagaagca taatctggat
    22381 aaacttcctt gatagaattg ctggtctttt ttgaaatccc tacaattgta ttcgcagcat
    22441 ccaactggct tctatgtgat tctcttttag agctatcctt aagaagttct tcaatacttc
    22501 catgaatcca agatatcttc ttgacttctc ttcttttaga gaacaacagt ggtggattca
    22561 taatggtaaa agaaacttca acatcataat catcttttac aagcaaacga cgagtcagtc
    22621 ttggaaaata aattctcatt ctccacaaaa aagctcgtaa ccatctggtt tggcgataat
    22681 cttgaaggga ttttaaaatg cgtacattct ttggaacaga ttcatatccc ttgtcaaagt
    22741 gctccatttc aagaatatca atatcatact tttctggatc cagatttgaa acaatggttg
    22801 atagaatctt ctctgcacca cctccaagag aaaaagacca cataaaaaat aagatttttt
    22861 tcttagccac catattctcc cttgtattct gtataagact tatccatatc agcgatgaca
    22921 gcatcatgat gcggtacctg cttgtctgct ggtggaggcg tcatataatc cccaaaagca
    22981 gttctgagat agacatcata gccgattgga ataggcatct ctgttccttc aaatggcaag
    23041 aaaagattgt cttcaaaaga tgtgattggg tacttgtttc tcatgtagcc aggacctgag
    23101 cataattctg taatgccatc acaatcagcc aaatcatact tagtcatttc tttctcagct
    23161 tttttccaga tgcgataacg gagagatttt ggagtcaaac ccagtaaaat gcgacttccc
    23221 catttcatga gagcaccatg cttttctgga atagtttgcg cacaaaagag tgaataaatc
    23281 aaggcccaac gaacctgttt tttccgctca gctggatttt tcggataata atccaaaggc
    23341 aaaacatcca aggccagacc atgtggcaaa tccaaatcct gctgataagg cttgatacag
    23401 gtggtttcct tgtcacgaat ggtaataaaa agattacgat caacaaaatt cttgtgactc
    23461 tttgacaaga aataacgttc atctgcataa cgaggccata attctgctaa tttctcataa
    23521 tctttacgag gcataaaaaa gtctaggtcg tcgtcccaag gaataaatcc cttgtttcga
    23581 agggcaccaa tagcgcctcc gccacagaga taacagagca aatcatgttc tttacaaaag
    23641 gccacaaaat attcagccat ctccagacta cgagcctgaa ttgcttttaa atcagtcata
    23701 ttgttcatta ttctttctat cgtatcgttt cattatacca caaacaaggg gtgaaaatct
    23761 attgcagact gtaaaaaatc aaagcctgac tgctatccaa atagctatca aactttgatt
    23821 tttctgtctt atactcttcg aaaatctctt caaagcacgt cagctttacc ttgccgtagg
    23881 tataggtaac tgacttcgtc agtcttatct ataacctcaa aactgtgttt ttagcagcct
    23941 gcggctagct tcctagtttg cactttgatt ttcattgagt attatcttat ctcaagccca
    24001 tttgagcgag cttggtttga tatttgtttt gatcaaccag caagcccaag cctccataaa
    24061 catcataggc atctacccag tcacccagtt ctggaatcgt caatttttca ataccatttt
    24121 ttgctccatc caaaacagat aaaccgtttg ttaggaggaa agtatagggt acgttggttg
    24181 aggtcatagc aaaaaccttt ccaagagctt cagaaccagt gaaaagttta gtgggatctt
    24241 taatttgctc taaaattgct gttaaaactt gttgctgtct ttttgtacgg ccgtaatccg
    24301 cctcatcatc atcacggaaa cgagcataat tgagcagggt cgagccattc atctgctgtt
    24361 ttccgacttt aatggtttgg gttggagact cagtctcggt agcatataaa tcatctccga
    24421 ctgtagcttc tgttagggga cgcccattca atgttgaaaa ttgagcatca atcgtcaccc
    24481 catcagggaa aagcgtgtca atcgctgtgg caaaggcctg gaaatcaacc aaggcgtagt
    24541 acttaatgtc caagtcaaaa ttatctttca agacttggcg aaccatttct gccccttttt
    24601 gcccctcttg ttctcctaac tcgtaggcta cgtttaactt gttatctgtc tgttttctac
    24661 cattaatcac ttgactataa ccatctatat agaccaaatt atcacgcatg aaactgacta
    24721 gcttcatttt cttatctgag cccccgacat ttaataccat aatagagtca gttcgtgtct
    24781 caacactgtt ctggccgatt cgaccatcag tacccatgat taaaatatta actccatctc
    24841 tagtgtcctg accattaaag acttctactt gagctgcccg ggcatcagca gttttctttg
    24901 cgctagcatc ttggtaacca cgcaaaaaca tgaataccat ggccaaagcc acacagacca
    24961 aaagtgaaaa aatcaccata aaaattcgtt taagacggag cttccgtctt ttcttttttg
    25021 gagggaaaga gagtgcttgt gatttggatt gtgagcgact ccggttcgca tagcttggta
    25081 agtcaacctg ctcttctctt tcttgttcca agctagagct actatttccc ctagcaagag
    25141 ttagcttttc ttgcaaatag gcaaactcat ttttttctct ctcattgaga tagtgaatat
    25201 tttttagcaa ataatcataa cgcaactgct catgatgact taagggattt tctttactca
    25261 tcttctctcc tttccatggt ctgatattgg ataaatagga taggcaccca gaattttata
    25321 ctggattcca atcgcttcta attctttttg ggcaaagtgg accaagtcct tatcggtata
    25381 atccacatcg ataatgaaaa agtattcacc cagtgctgtc ttgagtggac gactttcaat
    25441 ttttgtcaag tcaattcctc gccaagcaaa ggtcgacagg gccttataaa gtgcacctgg
    25501 aaggttgtca ggtaatgtca aggccaaact catcttttca gtttgtgctt gcaagggaat
    25561 actaggcttt tcagctccta gaagccagaa acgtgtgaaa ttggcttcca tttcctgaat
    25621 atcctcggca atcagttcca atccatattc ttcagcagaa cttctaggtg caactgctgc
    25681 aaagggctga tctggatgtt cggaaataaa acgggccgca taagctgtac tagctgttac
    25741 ctcgatttga gcctctggat attgttcatc gatgaatttc tttccttgag ccaaggcctg
    25801 tggatgtgaa aaaatctttt caatcttagt atggcctgga accaccatca actgctgatg
    25861 aataggctga acgatttctg ctactgcttg gatgtgagcc tgatgaaaaa gatagtccaa
    25921 ggtttcatga acactaccct caatagaatt ttcaactggc accacagaat agtccactaa
    25981 tccttgctca taagccttga tgacatctgt aatgttggca aaagcctgca attcctcatg
    26041 aggaaaagct atctgcacaa cgtggtgtga aaatgatccc ttgggaccta gataagcaat
    26101 tttcatctta gttcctctat aatttcctct gggcttagct tggtcacatc caaaacccga
    26161 ctagccactt cctcatacca agcctgtctt tcttgaaaaa tagctactag ttcttccttg
    26221 ctattattta gaaaaagcgg tcgctgattg tccttatcag ctgcgatacg ttggtagagg
    26281 gtttcaaaat ctgctttcag gtagatgtta tctgtattag tcttgagtaa gtcacgattt
    26341 ctctgagaaa taaccactcc tcctccagtt gacacgactt ggtctgtttg tagtaaatca
    26401 gctaggactt ctgattctac ctgacgaaag gctgcttctc ccttttcagc gaaaaaattc
    26461 gcaatggaca tacctaggcg cttctcaatc agagcatcca tatcaaggta attagggttc
    26521 aagcctcttg caatagtcga ttttccagcc cccataaacc ctaataacac cttagccatg
    26581 aatcaagctc tccaaatcat caaagaaact aggatagctg gtattgatgg cttctgcacg
    26641 gtcaagctcc acctctccat ctgcaaccaa gagggctgcg atagctgtca tcatgccgat
    26701 acggtggtca ccaaacgtat tgactctagc accgtgaaga gctgatttcc ctttgataat
    26761 catcccatct gccgtaggag taatatctgc tcccatacta tttaaggcgt ctgccacaac
    26821 ctgaatacgg tctgtttcct tgaccttgag ctcctcagca tccttgataa ctgttacacc
    26881 ttgggcttga gtcgcaagca gggcaataat gggcaattca tcaatcaatc gtggaatcaa
    26941 agcgccacca atctctgttc ctttcaagtc agaagactca acagtcaagg tagaagattt
    27001 agcgactgga tcgatttcag ttatttccaa ttttccaccc atggcacgaa tgacatcaat
    27061 aataccggtg cgagtttcgt tgatccccac attctgcagc actagacgag aatttggaac
    27121 aatcaaacct gcgactaacc aaaaggctgc actggaaata tctcctggta cgaccacctt
    27181 ctgtcctgtc aatttttgtg gcccttggac tgtgattttc ttaccgtcca cacttaaatg
    27241 accaccaaat tgtttcaaca tatcttcagt atgattacgg gtgcactctt tttcgataat
    27301 aactgactcc cccttagctt gtaaggctgc aaacatcaag gctgacttga cttgggcaga
    27361 ggcaattggc aactcataat gaataggtct taggtttttc gtccctttta agcgaagggg
    27421 aggcaagtct cgttcagttt gccctgaaat gctgacgccc atttttttca gtggaagggt
    27481 cacacggtcc ataggacgtt tggaaagact atcatctcca aacatctcta cttcgaaatc
    27541 tgcaccagca aggacacctg aaatcaggcg aatcgaggtg ccagaatttc ccatattaag
    27601 ggcattttgt ggcgctttta agccagccat gcctacacct tgaatggtaa taaccccatc
    27661 tttatcctca atttcaacac caaggtcacg aaaaacctgc atggtcgaaa gaacgtcttc
    27721 acctcgcaga atatcataaa ccttggtctc accctcagcc aaacttccaa agataatgga
    27781 acggtggctg atagacttgt cacctgggac gcggatacta ccatgtaaat ggcgaatgtt
    27841 tgtttttagt ttcatactgg acctcatact tgcaatactt ttacctattt tatcataaaa
    27901 agccagaaat tccttaaaaa ttcctgactt taggatagtt cttttcttat ttcagcaatt
    27961 ctgaaactgg ttcaaaaaca attttttcaa tgtcagaaag gtaaatggcc aattgttgtt
    28021 gcttggtaaa gaattctgac aagaggctat ttccttgaat ctgtttacca aagccttcca
    28081 tcttagcttg gaaggacgca tctggcattt gacctgtatg tgctagtttt tgaatttcct
    28141 cttgaaaggc aagatattct gtaaagattt tgcttgcctc agcatctgct gcaatcgcat
    28201 ctttagctgc tttaacagcc ttgtattctg gtaatccgcg tagaccgcga ctgagttcgt
    28261 ttgcactatc gtaaatattt gacatgttct tctccttatt tgatgacgac tgtatagtcg
    28321 gtattttctg ttatgagatg ctcagctctt tccaagtctt gagcattttt aaatgaaatt
    28381 tgtaggattc cgtgaatatc ctcacgattt tcctcgttga tgtggatgtt aaccaaggaa
    28441 gttccacgta gcagttccaa aatccgcagg atgacatctt cttcatcagg aacgtcaaca
    28501 tagaggtcgt aagagctatc cacaccacca cgcttatgga tttccatggt ctggcgttgt
    28561 tcacgcgctt ggttaaaaaa gttccaaatt tgctcttcat ctcccttact aatggcctga
    28621 ccaatcactt ccaaacgttc cttgaaatcc tcaattctat ccagaatggt ctcgctattg
    28681 gacaagagaa tggaggtcca cattcctggc tcgctttccg caattcgggt catatctcga
    28741 aaaccacctg ccgcaaagcg ccttgccatc tcatgctctt gagcatagac cgcagtctgc
    28801 tccatgagac tagaagccaa aatatgagga aaatggctaa tctgagaagt gacacgatca
    28861 tgctccttgg catcaatctc gataaaacga gcatgaagac ctgaaagcag atccttcatt
    28921 tccttaagcg tgtcctgact tgtcaggctt gaaggtgtaa agatataata ggcattttca
    28981 aaaagattga catctgccga agcagcccct gtcttgtgac taccagccat gggatgggcc
    29041 ccgacaaagc gaacagactt gccagccaaa tactgctccg ccgcatccac aatggttgac
    29101 ttggtcgaac cagcatctga aataataacg ccttctcgca aatccaaatt ggccaactcc
    29161 ttaatgaaag caatagtttg tttgattggc aagctgagga taatgacatc tgccaaagga
    29221 gcaaaactag caaaatcatc cgttgcacgg tcaatcatgc cttctttcaa ggcgatatct
    29281 ctcgaagctt gactacgatt ataacctaaa atttcataat ctggatgatc gcgtttgata
    29341 ccaagtgcca tagaggctcc aatcaaccca agacctgcga tatagattgt ttttgccata
    29401 ggaactcctt aatagttctt tgtatagtct cggtgtttgg ctaccgcttc ttttagttcc
    29461 tcaagattat ctgatgagaa tttttcgagg atttcttgcg ccagaaccgt tgctacaact
    29521 gcttccatga ccattcctgc agctggaaga gcagtcggat cacttctctc cacggttgcc
    29581 ttgtaaggtt cgtgggtttc gatatccaca ctcataagag gtttataaag agtaggaatg
    29641 ggtttcatga ccccacgaac aacgatgggt tgcccattag tcataccacc ttcaaaacca
    29701 cctagattat tggtacggcg agtataaccg tcttctttag accagagaat ttcatccata
    29761 acttggctgc ctttacgata accagcctca aagccaagac caaattccac ccctttaaag
    29821 gcattgatag agacaacagc ttgagccaat cttgcatcca attttctatc ccattggaca
    29881 taggaaccaa gaccaactgg aacgcctccg acgactgtct ccacaacccc accgatggta
    29941 tcaccatcac gtttgatttg gtcaatatag tccttgattt cctgttctcg ttcttggtta
    30001 acaatagaaa cttcagactg ggcagctctt tgcttaattt cagcgactgt cagattttca
    30061 ggaacatcga tttccttgcc accaaagacc acgacatggt tggcaatctc catatccagc
    30121 tcagccaaga ggcgtttggc tactgcacca actgccaccc gcatggtggt ttcacgagct
    30181 gatgaacgct ccaaagaatt tcgcaaatca tcaaaacggt acttaatccc cccaaccaaa
    30241 tcggcatgac ctgggcgagg atgagtaatt ttccgcttgc ttttaaggcg gtcttcaatg
    30301 tcctccgcag acatgatgtc cagccatttc tggtggtcct tattgatgac atccatagta
    30361 ataggcgccc ctgtcgtctt cccgtggcga acgcccgaag taaagacaac ctggtcactc
    30421 tcaatcttca tacgaccacc acgaccgtag ccaccctgac ggcgtctaag gtcctcattg
    30481 atatcctcag ctgtcaatgg aagtccagct ggaattccct caataatagc tgttagacgg
    30541 gggccgtgtg attctcctgc agttaaatat ctcatacact ctccttattt taccaagtag
    30601 tctttcatct cttccagaga aactgggtga atgatcgctg aaccaagctc tggcaccaag
    30661 accaatttca aggtgttacc acgcgctttc ttgtcatgag taagagcctg ataaagcttg
    30721 tcaacttccc aattttcata gtcaacaggc aagccgaatt tctgacacat ctctgtgata
    30781 gattgggtaa tgccagctgg catgaggcct ttttcctcag caaccttgga aatctgtacc
    30841 attcccatgg caacagcctc tccatgcatg accttgccat aaccggcagt cgcttcgatg
    30901 gcatggccaa tagtgtggcc aaaattgagg taaagacgaa taccattgtc caactcatct
    30961 tcaaccacca tcttgcgctt cacctgacaa gaatgttcaa tcaaggtctc tgcatgttcc
    31021 aaaatactct caacagaacc attcagtccc gtcaagagag cccacagttc tggatcctca
    31081 atcaagccat acttgataac ttcacccatc ccttcaatca actctttttt tccgagggtt
    31141 tcaagaacaa gtggatcaat cagaacccca tctggttggg caaaggtccc caccatattt
    31201 ttagcaaatg gtgtgttaac gcctgtcttt ccaccgatag aagaatcaac ctgagctgtc
    31261 aaactagtcg gaatctgaac aaagtgaata ccccgcatat aggtagaggc tacaaagcca
    31321 gccaggtccc caacaacgcc accaccaaga gcaacgattc catcgctacg agtcagacct
    31381 tgcttgacta gaaattcata gactttctga acagtagtta aattctttct ttcttcacct
    31441 tctaagaaat caaaaacagc tacctgaaaa ccagcatctt ctaggctgag cttgaccttc
    31501 tctgcataga gagaggctac atggttatct gtcacaatga ctaccttttg cggttgccag
    31561 agttctcgca accactgacc agcctgggcc atacaacctt tttcaatctg aatatcataa
    31621 ggatgatgag gaatatcgat tctgattttc ataggagagt ctccctttct ttattggtat
    31681 ttttctgtta aagactgcca aatctcttct gtcggcattt ccttgcctgt ccatagttga
    31741 aaagcttctg cagcttgata gagcaacatt cccagaccat tgactgctgg attgccctga
    31801 cttctagccc atttcaaaaa cggtgtttca aagggttggt atatgatatc tgcaactaag
    31861 agagtttctg gtaagactat gttttcagga acaggagaga attggccatc catgcccaca
    31921 ctggtggcat taactagcaa atccgactcg gcaatccttg cttgcagttc agaaacatat
    31981 tctaaagcac acaaatccac tttaaagcct gtctgctcct gtaacttgtc taggtaaggt
    32041 cttgtttttt ccatagaaac ggaacgaaca aagaccgaaa tctgactgac gccatccaaa
    32101 atagcctgtg ccaagattga tttagccgca ccacctgcac ccagcaggat catcttttta
    32161 cctgaaattg taaaagaagg caagcactta aaaaatccct tgccatctgt attatatcca
    32221 attaaattgc cattctcatt gacaaccgta ttaaccgcac caatcaagcg cgcttcatcg
    32281 ctcagcttat ccaaataagg aatcacctgc tccttatagg gcatggacag attgatgcca
    32341 aacatctggt agcgacgaat attggccact gtttctacca agtcactcgc ttcaatctcc
    32401 caagccacat aagcaccgtt ggtagctgtc gcctcaaagg ctctattgtg gatgaaggga
    32461 gaaatagaat gcttaatagg attggcaaca actgcagcta aacgtgtata gccatcaagc
    32521 ttcatccaaa atctccctga tttttttcat gctagctaga gaaatctgcc caggggcact
    32581 aacctcatcc agactggcaa aagaccaact cgaaccagtc acatccgcag tgatacgaga
    32641 gaccttgccc accttaccca tagaaatggt cacatattcc tgttcaggat tgagggtttt
    32701 aaagcctcgt gtatagttca tcaagtctaa gacatcctgc tccgtgtgag ccatcaccgc
    32761 aaccttaaca agttttggat ttagaatcgt caactctgac aagatttcca tcatgttctc
    32821 aggtgtttct tggaaattat ggtaactcaa aacaagattt gggaagtcca gcatttcctc
    32881 aaaaacatcc ttgtagctat agtactcaaa atcaatatag tctggttgat agagttgcgc
    32941 aacttccttg attagatgga tatactcttc tggagaaagg tcgatttctc caccttcgga
    33001 gcgagttcgt agcgtgaaaa ccaactcacg gcctgcgaat ttttcaaaaa tggctggagc
    33061 tacctgcaaa atcgcttctt taggcagata gtcggcacgc cattcaatga tgtcggcatc
    33121 caggtacctc gtggcatcca gagcctgagc ctcctctaaa cttcttggca ttactgaaac
    33181 gattaatttc atttactaac cttcatacta atcaccttga ggtaattact actttcatct
    33241 tttttattat aggcaaaatc tgctggaaga ccatatttgt ttaaaatctg gtaacttctt
    33301 cctgcaaagc ctttatcaat ttgttctgta aatttctgac gggaaacatt ggcagcattg
    33361 gtactggcaa tgataatccc tcccggattt aaaatctcaa gactctggga aatcaacttg
    33421 tgataatcct tggccacaga gaaagtttgt tttttattcc gagcaaagct aggcggatct
    33481 aggacaatca catcgtaggt caagtttttg cgtttggcat atttgaaata ctcaaagaca
    33541 tccatgacta taaaacgatg ctcgtctgtg ctgagcccat ttgcctgaaa atgcgcttga
    33601 gacaattctc gtgaacgttt ggctagatca acagaagttg tctggctagc tcctcccatg
    33661 gccgcagcta ctgaaaaagc cgctgtgtag gaaaacatat tgagcaagga tttacccata
    33721 gccaagccgt caactaaact accgcgaacc tcatgctggt ctaggaaaat tcctgtcatc
    33781 aagccatcat tcataaagac ttgatacagg acaccatttt ctaaaacagt gaaaaagtca
    33841 ggtgcttctt gaccataaac atgggcagat tcatagtcca aacccttaaa gcggattttc
    33901 tcataagccc ctaaaacctc agggaaaacc tgtctaaagg cttctgatat agtctgacga
    33961 atctgataaa cataagagtt ataccaagaa aagacggcgt agtcgccata aaggtccact
    34021 gtcagacccc caaagccatc tccctcttga ttaaagagac gaaaggcagt tgtcaaatca
    34081 tcttgatagt aggcgtttct cttttctttg gcttttctaa acaacgtttc aaagaaagct
    34141 tgattgaagg ccaccttgtc tttgctgata aaccagccca agcccttgtt ttgctgagaa
    34201 aggtaggcag tcccaagaaa gtttccttcc tgaccctgca cctctacttc ccgatcctta
    34261 agattgacat tctcaagatc actggcttct agtaaaacta gccccttagc aagcttcttt
    34321 tcaacccttt tgctgactct tattctattc ataactacca ttatatcaaa cttttagaca
    34381 attctcaaaa aagaaactac ccttgctttt ttactcttct tttaaaaaat ggtatactag
    34441 acttcctgca aaactaggaa ataaatgtgt aagaatcaca ataaaaaatg ctcttccgtc
    34501 ttggaggagc atttcttttt atcaacgaaa atcaaatagc aaactatgaa actagcctca
    34561 ggttaaccgt gagattatag gtagagaggt tgtatcagca atatgtgtct gtcaaattta
    34621 gtgacaaagg tagtagaaga aagatgaaga aataaatcag cttcagtagg tatctggaaa
    34681 atttgatttt atagagaagc cttttgttac aaactcaata tactatcaat aaataatatt
    34741 atagaagcaa caataattaa aatttcacct atttgcatca ttctatttcg aactctaaat
    34801 atatgttcta tcaaaaatac ttggatcaca cacattatag gaattaacgt ttttgaaatt
    34861 gaaaaatatc ccaataaata aactataaac aacaataata gaactatatt atatttctta
    34921 ttcaaaacat tcctccctat atttttgatt accaatctta atcatttaca actacattct
    34981 aacaaactat aaaagcgttt gtcgaattga atttatcaag caagcaacca actatctcat
    35041 cttttttcta tttctgccaa tatgcgtgac aggtaataat gatagccaaa aatagcaaga
    35101 gcaagcaaga cgataagagc tcctactccc aagttgatgg caaggatagg ggagagagac
    35161 tgaaccaaga atatgctccc aattacaagg gccatcagga ttgcactata aataaacaat
    35221 aaaactatgg cgactatgcc atttgaacga ttcaccaggt ccgtaatgct actccaattg
    35281 gttgacagat ttttaacgtc cttaaagtaa tggtggcaag aaaggatgac actggcaatg
    35341 atccagacta caagaaggta aatcatcgaa aggatggaca agcctagata tagagaaaga
    35401 ccgagcaaag tcagaactgg taaaaaggac tgaacagcaa agataatcca aaatttcact
    35461 ttcacataac gagcaaagtc aaagggtaaa ctcttcagaa aatcaacatt ttccctctcc
    35521 aaggacaagg caattgaatg caggctggtg atattgttat tgacaactgc tataaacact
    35581 cctacaaaaa acaagggtaa ccagtatgga ggatgaatgt ctggaactat ctgagaatct
    35641 cggattttgg aaatcagact gatcatcatg agataaggaa ggaaagcact tgtaaaaagc
    35701 actgtaatca caccagtccc ctgtcccaag agggtgaggt ggtagcgtaa aaccatacgg
    35761 aaaaagccct ttttagtagt tgaaatcctc tccttgctgc gacgttcttt tttgaccttc
    35821 tcctcactgt taagcaggat cacgtcataa aaacgaggaa ggaccttctt tttggtcaga
    35881 taaagcagga agagagttag tcctatccaa gcgagcagac ccactaaggc ttctgtcgaa
    35941 aaaggctcca ctgctatttt gtaaaagata tgaagaggat aaaggagaaa tggaatgtct
    36001 ctaactttgt caacaatact tccaaaagtc gactgaagaa agaagataaa tattaaaggt
    36061 atgagaactc ctatcccaat catcacattc gaaaaaatag actgatactt tctgaagacc
    36121 ctagtctgag ccaagaaatg tactgccact accgtcacta aagtaacaga gacaaataat
    36181 aaggtcaagg acagtagcat caaaggcaaa cccagccaaa gagaaggagc tagactaata
    36241 tagagggcta gaaaataagc taggattggt acaattccag ttagagctgg caagaggaca
    36301 gacagacctt tggccattat aatctctgat tctttaaagg catagggcct ataggaggcc
    36361 aggtccttac tctcataaaa gacattgtaa aaggcagtga aagaagttga aaaggccagc
    36421 accagtaaaa tagcaaccat cgagctaaaa taaataggca tttcctcaaa aggaaaatga
    36481 atggctatat tactaaaaca gatgagcatc aagagactgg aaaaaatgta agaacttagg
    36541 actctagcag aaacatttac ttttttccca ggattcttag cctgcttctt tcgtagatta
    36601 gccagattag cttcttgaga tgaatagagg atattgatat caactaattt tttaatgacc
    36661 ttgagacgca tccgcaacct cctcttttct accagcaaga ctaaggtaga tactttccaa
    36721 aaactggtct gggtggtctt tcctcaagtt ctctacacta ccacaataga tcaaatgccc
    36781 ctttttcaaa atagcaatcc gatcacagac ttgctcggct acctcaagga catgagttga
    36841 aaacaagacc gtcttgcctt tttgtgcatg ttccttcatc atttgcttca aatcaaaggc
    36901 ggcctgggga tccaaaccag tcaagggttc gtccaaaacc caaatatcag gagcagacaa
    36961 gagtgcccca atgacaaaga ctttctgacg cattccgtga gaaagagttt caataacctg
    37021 atagcggttt tcagcaaaat caaaaacgtt caatagccta gctagactag tctccaagtc
    37081 agagctagtc agatcatagg atgaagcgat caattcccaa aattcattgg ccgttaagcg
    37141 taaaaataag tcaggcgagt ctgctacgta gccaatcttt cgtttgatcg ccaagcgatt
    37201 ttccgataac tcctgaccgt ctaccaaaat acgaccactg ctgggtgaaa tgatactgac
    37261 tagggatttt atggtggtcg attttccagc cccattatga ccaatcaagc ccataatctc
    37321 tccattttca atctgcaaat tgagattact caaggcctct ttatcaccat acaacttact
    37381 aacattttga aattcaatca tgggacaact cctatcttta tctgtattat acatcgctat
    37441 actagcactt tgatacaaaa aaatcaatac tttattttaa gtagttaaaa tagtttcctt
    37501 ctatcttacg caaacgtttg cgccgagaga tactttatga tagaataaag aacaagattg
    37561 acaagtaaga ggaaacatca tgcaaaatca aacactcatg caatactttg aatggtatct
    37621 gccccacgac ggtcaacact ggacgcgtct ggctgaaaat gctccacacc tagctcatct
    37681 ggggatcagt cacgtctgga tgccaccagc cttcaaggca accaacgaaa aagatgtcgg
    37741 ctatggggtc tatgacttat ttgacttagg agagttcaac caaaaaggga ctgtccgcac
    37801 caagtatggt ttcaaagaag actatcttca agccattcaa gcccttaaag aacagggaat
    37861 tcaacctatg gccgatgtag ttctcaacca caaggctgct gccgataaca gggaagcctt
    37921 tcaggttatc gaagttgatc ctgtagaccg tacagttgaa cttggagaac ccttcaccat
    37981 caatggctgg actagtttta ccttcgatgg tcgccaagat acctataatg gcttccactg
    38041 gcattggtac cacttcaccg gtacagacta cgatgccaaa cgcagtaaat ctgggattta
    38101 tctgatccaa ggggacaaca agggctgggc taacgaggaa ttggtcgata acgaaaacgg
    38161 aaactacgac tacctcatgt atgccgacct agactttaaa catcctgaag tcatccaaaa
    38221 catctatgac tgggctgatt ggttcatgga aacgactggt gtagctggtt tccgtttgga
    38281 tgccgttaag catattgact ctttctttat gcgcaacttc atccgcgata tgaaggaaaa
    38341 atacggtgac gatttctatg tttttggtga attttggaac ccagacaagg aagccaatct
    38401 ggactatctc gaaaaaacgg aagaacactt tgaccttgtc gatgttcgtc tccaccagaa
    38461 tctctttgaa gccagtcaag ctggcgcaaa ctatgacctt cgtggcattt tcacagatag
    38521 cctggttgaa ctcaagcctg acaaggctgt gacttttgtc gacaaccacg atacccaacg
    38581 aggacaagcc cttgagtcta ccgttgaaga atggttcaag ccagcagcct atgccctcat
    38641 tttgttacgc caagacggcc ttccatgtgt cttttacgga gactactatg ggatttcagg
    38701 ccagtatgct caagaagatt tcaaagaaat ccttgaccgc ctcctagcca tccgaaaaga
    38761 cttggcctat ggagaacaaa atgactactt tgaccatgct aactgtatcg gttgggtacg
    38821 ttcaggtgct gaaaatcaat ccccaatcgc agtccttatc tcaaatgacc aagaaaacag
    38881 caagtcaatg tttgtcggtc aagaatggac taatcaaacc tttgtagatt tacttggtaa
    38941 ccaccaaggt caagttacaa ttgatgagga aggttatgga caattccctg tctcagctag
    39001 atccgtaagt gtctgggcag tcaataccat ctaatagctc ataataacca agctaggtcc
    39061 aagcggattt ggcttttttg tattcacaaa aagacctacc caaatggata gatctttact
    39121 tgattacaat ttacctgcta ctgcatccaa caattcttgg atcttaggtt ggttgcttcc
    39181 tcctgccatg gccatgtctg gtttaccacc accacgtcca tcgatgattg gtgctaattc
    39241 tttgacaagg tttcctgcat gaaggtcttt tgtcttgctt gctacaagga cattgacttt
    39301 gtcaccgata gcggcaacta ggacaagaag atcagagtag tctttttgtt tccagttatc
    39361 tgcaaaagta cgaagggcac cggcatcgga tacagacact tgactagcaa tgtaacgatg
    39421 accgttgact tccttagcat ctttgaagat atcgcctgcg gctgcagctg cggctttttc
    39481 tttcaactca gcattttctt tttgaagttg acgaagttgt tcttgaagtc cttctacctt
    39541 gtgaggtact tccttgactt gaggtgcttt caaggttgct gcgacagctt taagagcatc
    39601 ctcttgttca cgataggctt caaaggcttc cttaccagtc actgccaaga tacggcgagt
    39661 tcctgaaccg attccttctt ctttgacaat tttgaagaga ccaatctcag aagtgttgcc
    39721 aacatgagta ccaccacaaa gttcaataga gtagtcaccg atagtcacga cacgaacttc
    39781 cttgccgtat ttctcaccaa agagggccat agctcccatt tctttagcag tgtcaatatc
    39841 cgtttcaact gtcttcactt caagtgcttc ccaaattttc tcgttaactt gctgttcaat
    39901 cgcacgaagt tcctcagcag ttactgcttg gaagtgggta aagtcaaagc gaaggaattc
    39961 aacttcgtta agagatcctg cctgtgttgc gtggtttcca aggatattgt gaagggcagc
    40021 gtgaagcaaa tgagtcgcag tgtggttttt catgacacgg tgacggcgat tgctatcaat
    40081 tgccaaggta tattcttggt tcaaggcaag cggtgcaagg acttcaactg tatgaagggc
    40141 ttgaccattt ggggctttct gaacattggt cacagtagcc acaatcttac ctgactcatc
    40201 caagatttgt ccgtagtcag ctacctgtcc acccatttca gcataaaatg acgtttccgc
    40261 aaagataaga gaggcagttc cttctgaaac agctcctact tctgcattgt cagcaacgat
    40321 agctaccaat ttagaagaca attggctagt attgtagttg aagacacttt ctacagtgat
    40381 gttttgaaga gtttcatttt gcatacccat tgagccaccc ttgacagctg acgcacgcgc
    40441 gcgttcttgc tgttctttca tggctgcttc aaaaccttca cggtctacag tcataccagc
    40501 ttcttcagca atttcttcag tcaattcaac tgggaatccg tatgtatcat agagtttaaa
    40561 gacatcttga ccagcaatga cagattgacc tttttctttc aagtctgcca caatgccttg
    40621 ggcaaagtgt tgacctgagt gaagggtacg ggcaaatgat tcttcttcgc tcttaacgat
    40681 tttctcaata aagtcacgtt tctcaagcac ttctgggtag tagctttcca tgatttttcc
    40741 aacagttgga acaagtttgt aaaggaaagg ctcgttgata cccaattttt gaccatgcat
    40801 agaagcacga cggagaagac gacgaagaac ataaccacga ccttcatttc ctggaagggc
    40861 accatcaccg atagcaaatg aaagagaacg aatgtggtct gcgataacct tgaagctcat
    40921 gttgtcgcca tcttggtcat aaaccttacc agacaatttc tcgacttcac ggataatcgg
    40981 catgaagagg tccgtttcaa agttggtctt agccccttgg ataacagcca ccaaacgctc
    41041 caaaccagcg cccgtatcaa tgttcttatg tggcaattcc ttgtattcgc tacgaggaac
    41101 agcagggtct gcgttaaatt gtgacaaaac gatgttccag atttcaatat aacggtcgtt
    41161 ttcaatatct tctgcaagca ggcgaagacc gatattttct gggtcaaagg cttccccacg
    41221 gtcaaagaag atttctgtat ctggtccaga aggtcccgca ccgatttccc agaagttgtc
    41281 ctcaattgga atcaagtgac ttggatccac tcccacttca atccagcggt tgtaagaatc
    41341 tttatcgtct ggatagtagg tcatgtaaag tttttcagca gggaaatcaa accattcagg
    41401 gcttgtcaaa agctcataag cccaagtgat agcttcgtca cggaagtaat ccccgataga
    41461 gaagttcccc agcatttcaa acatggtatg gtgacgcgca gtcttcccta cgttttcgat
    41521 gtcgttggta cggatagcct tttgggcatt ggtaatacgt ggattttcag ggataatggt
    41581 cccgtcaaag tatttcttaa gggttgctac cccagagttg atccacaaaa gagttgggtc
    41641 atttacagga accaaactta ctgatggttc tactgagtga gctttggtcg cccagaaatc
    41701 aagccacatt tggcgtactt gtgcactaga tagttgtttc atattgtctc cttatttact
    41761 tgtttaatgt gattggcttt ccagcatttc cacatagtca atcgcgacac agagggaaat
    41821 gactaggtct gcataagcgt cctcaagaac cgttacggta taggtagagg tcagatggaa
    41881 gagttccttc ttaatttccg caatcagctg atcgcgatca tccagcaatt ggaaattcaa
    41941 atcccagata ttgccctcga tacgaagacc tagattatca aactcatact tatctcgcca
    42001 gaaggtcaac ttcttacgaa tgacaaaact cgagccatcc cgaagctgaa tctcaaaacg
    42061 aggaagcaag gtcaagattt ctttactaat ctgactgact tgttcaccag ccgcatcata
    42121 gatggtaaag gttttaggaa tcttaaaaaa tgatccctcc acctgatagg caatttctcc
    42181 cctgtcattc ttgatagcga agcgttcgcc tccaagacga aacttttgtt tgacaagaaa
    42241 tgttttcatc aacacctcca aaaatcaaaa gacaagctca tatcacgaag ggcgaaaaac
    42301 cgcggtacca ccttcattca atgaacttgt cattctcttg ttcttatgca attgtatgat
    42361 tgagtagcat gacttcctag cttagatggc tcgcagcacc gccatttctc tggactaaga
    42421 caagtgaaaa tcaattctca actttcttat tatatcgttt ttttaatctt gcgtcaactg
    42481 gaaatgatct ccgttgaatt agaccaattc cctacatctc tgattacttt ttcaggatat
    42541 attttttctt actgccattt ttctttttat cccaaatttt catagtacta aacacagcta
    42601 ctagaatatt tccaaatata aaggtgccta tcacccaata tatggactca gttgttaggt
    42661 attgtcgatc caagccatcc tttaaatgga atagtatagc agtttggtta acaatcataa
    42721 aggttggcca gaaacttttt ttgaaaaaag tagacatttt cattatttgt tgccgctttc
    42781 tgtaaggtta atactcaata aaaatcaaaa agcaaactag gaagctagcc tcaagctgta
    42841 cttgagtacg gcaaggcaac gctgacgtgg tttgaagagt ataggcttag tatactacta
    42901 ggcaagcaaa taagcaaata aacaaataaa caaataaaca actagaatag aaaaagatag
    42961 ggctctaaaa actgacttct attccttaaa aacgaaccag cttgactgat tcgtcttctt
    43021 acgtttatct cctacttccg atacatttta aactgtagga agaggtcgct atatttccct
    43081 gtccatttat ggtcaaattt ctcataaact tctaggtgtt tcatggtttc aacatcggga
    43141 tagaaggcct tatcttcctt tgtttcctct gggagcaatt ccttcgctgg taggtttggt
    43201 gttgaatagc cgacatactc cgcattttgg agagcatttt caggtttcaa cataaagttg
    43261 ataaaggcat aagctgagtt ttggttttta actgttttgg gaatgaccat attgtcaaac
    43321 caaagattgc tggcctctgt cggtaccaca taacgtagat tttcattttt ttctaacatt
    43381 tggctggctt caccagagaa ggtcacgccg attgcaacat tattctgaat catatagccc
    43441 ttcatctcgt ccgcaacgat agccttgata tttggagtca gtttgtagag cttatccact
    43501 gtctcttcca actgctgcag atccttggag ttgaggctgt agccgaggga attgagtcct
    43561 agtcccagca cctcacgcgc cccatcaaag agcatgatag aattcttata ctccggcttc
    43621 caaaggtcat cccaatgctc aggcgcttca tctaccatgg tttcgttgta gacaattcct
    43681 aaggttcccc agaagtaagg gatggagaat ttattacctg ggtcaaagga ctggttgaga
    43741 aactctggtc cgatattttc gattccttca atttttgaat aatcaagcgg aaccaagagg
    43801 tcttcgtcct tcatcttgtt aatcatgtat tcacttggaa tggcaatatc gtaggtcgtt
    43861 ccaccctgct ttatcttagt gtacatggct tcgttggagt caaaagtctc gtactgaact
    43921 tgaattcctg tttcttctgt aaactgagtc aagagttcag gatcgatata gtctccccag
    43981 ttatagataa ccaatttttg actatctcga ctattgattt tactatctaa atgagtcgca
    44041 attccccaca agacaaggat aatcgctgca attcctgcta aaaatgaata gatttttttc
    44101 atgcttgctc ctccttctca cgagagataa agtaataacc tacaactagg ataatactaa
    44161 agagaaagac tagagcagac agggcattga tttctaagga aatccccttg cgagcacgag
    44221 agtaaatctc gactgatagg gttgaaaagc catttcctgt tacaaagaag gtcacggcaa
    44281 agtcatctaa cgaataggtg aaggccatga aataaccagt aatgatagac ggagtcaggt
    44341 aaggaagcat gatttccttg aacatctgaa attgactagc tcccaagtca taggccgcat
    44401 gaatcatgtc gccattcatt tccttgagtc gaggcaagac catcaagacc acgataggaa
    44461 tggagaaggc cacgtgacta gatagaacgg tcaaaaagcc aagtgaaaac ttgagttggg
    44521 taaagagaat caagaagcta gcaccaatca taacgtcagg cgcaaccatg aggatattat
    44581 tgagtgatag aaaggcttct tggtatttct tacgagactg gtagatgtaa atggcaccaa
    44641 aagtcccgat aatggtcgct atcaaggctg ataggaaggc caagaaaaat gtctgagcca
    44701 aaatcagcat gagtctccca tctccaaaca tggtttcaaa gtgagtccag ctaaaacctg
    44761 taaagctatt catatcatca ccagcattaa aggcatagcc aatcaagtaa aagataggca
    44821 ggtagaggac cagaaagacc agtcccagat aaaggttggc aaattttttc atcgttctct
    44881 cctttcctta gtcacccaca tggtgatgaa catggtcagg atgagaatca caccgatggt
    44941 tgaacccata ccatagttgt cattggttag aaaattctgc tcaatagccg tccccaaggt
    45001 gataacgcgg ttcccaccaa tcaaacgggt cagcatgaag agactcaaac ttgggataaa
    45061 gaccgactga accccacttc gcacaccgtt catagataga gggaagatga catgacggaa
    45121 ggtctcccac ttagttgcac caaggtcata actagcattg atgagattat tatccatgtc
    45181 gtctaagaca ttgaaaatcg gcaaaatcat aaaggggagc tcgatgtagc ttgcgacaaa
    45241 gataaaggaa aaatcggtaa aaagcaactg ttgtgaacca attccgataa attccaagaa
    45301 ttggttaata gagccatttt gaccaaaaat cccgataaaa gcataggctt taaggagcaa
    45361 attgatccag gtaggaagga taatcagcat gagccagagt tgacggtgct tgagacgggt
    45421 caaaaagagg gctgttggat agctgataag caaggtcaca aaggtcacaa tccctgcata
    45481 aagcactgag ttgaaactca ttttgaggta ggtcaagttt tgtgacgcaa agtaagattt
    45541 ataattttct aaactaaact ggccttcaat gttgaaaaag gattgtccga aaatcaagac
    45601 caagggtgcc aatacaaaga gggcaatcca aagcatgtag ggcactacaa agagtttaga
    45661 gcttgttttc ttcatctctt tcctcctcga tcgcattgat cagacctgct tcttgctctt
    45721 cgatttccac gtattcttcg atacgagcat cgaactcttc ttcggtttca ttgagacgca
    45781 tgatgtggat gtcttctggt tcaaagtcca gaccgatttc ctcacccacg atggccttac
    45841 gggttgagtg gatcatccat tcatttccaa gttcgtcata ggcgataatt tcataatgca
    45901 ccccacggaa gagctgggta tcgaccttaa cttgaagctt gccttcttca ggaagggtaa
    45961 tgcgcaagtc ctctggacga ataacgacct caacaggttc atttggcttc atcccaccat
    46021 caaccgcttc aaagcgtttg ccgttaaatt cgaccaagta gtcctcaatc atggtacctg
    46081 gcaagatgtt tgactccccg ataaaggtgg caacaaagtg gttgattggc tcatcgtaga
    46141 tgtccacagg ggttccagac tggacaatct cgccatcatt cataacgaaa atccagtcac
    46201 tcatggcaag agcttcttcc tgatcgtgag tgacaaagac aaaggtaatg cccaatcgtt
    46261 gttgcagttc acgcagttcg tactgcatgt ctgttcttaa tttcaagtcc agcgctgaca
    46321 agggctcatc caacaaaacc acacggggtt ggttgatgat agcacgggcg atagccacac
    46381 gctgacgttg tcctccagaa agtttgcgga tggaacgttt ttcataacct tccaactgaa
    46441 ccatcttgag aacttccgct acacgttgct cgatttcttt cttatcaatg ttacgcaagc
    46501 gaagtggaaa ggcaacattt tcaaacacat tcatatgtgg gaacaaggca taggattgga
    46561 agacagtatg tacgtcgcgc ttgttggttg gaatatcatt gatacgaaca ccgtctagca
    46621 tgatatctcc tgtcgtcgca tccagtaaac ctgcaataat gtttaggata gttgatttcc
    46681 ccgaaccaga tgcacctaga agggtgtaga atttcccttc ttccaactca aagttgatgt
    46741 ctttgagaac cttggtgttg ctgtcttcaa aaactttaga gacgtttttg aattcgataa
    46801 ttggtttttt caattggcat aaattccttc tttttcatag attaaccgat cggggctctg
    46861 tcaggtcccc actacctctt gcagggagta aaaccacctg catacatctt cgctaccgat
    46921 aggctttcac ccccctttcc atgacatagc agcagctttt caaatacagc ttcctacttg
    46981 ctttcaccca agatccggac ttctctttca agcgtaatac ctgagtgttc cttgactttt
    47041 tcgataaccg attggatcaa gtcctcgtag tctttggccg ttccatctgc gacattgatc
    47101 ataaatcctg catgcttttc tgacacttct acgccaccga tacgatagcc tttcaagcca
    47161 gcttctgaaa ttaactgacc tgcaaaatgc ccgactggac gcttaaagac cgagccacaa
    47221 gatgggtatt ccaaaggttg cttgagttca cgtaggtgcg tcaagcggtc catttcctgc
    47281 ttgataacct gatgggttcc tggggctagg gcaaatttaa ctgacaagac aactgcacca
    47341 gactcctgaa tagctgaatg gcggtaacca aaagccaagt ctttagcaga cagggtttcg
    47401 atttctccat ccttggtcaa gaccttacaa gactgcaata tgtgagcaat ctcgccacca
    47461 taggcacccg cattcataaa gacagcaccg ccaacgcttc ctggaatacc acaagcaaac
    47521 tcaaagccag tcaaactatg acggagggca atgcgagttg tttcaatcaa gttagcccca
    47581 gcttctgctt caatggtata gccatcaaca gaaacgttat tgagcttgtc acacaagatg
    47641 acaaatccac gaatcccacc atcacgaacg atgatattgc ttgcattgcc aagaaccatc
    47701 caagggatat tttcttggtt ggcaaatttc acaacgcgag ccaactcaaa acgatttcgt
    47761 ggaaagacca aataatcagc ctctccacct acttttgtat aactatagct atgcaagggt
    47821 tcctgaaaac ggatatcaat tccttctaag atttcaagca ttttttctct tacagacatg
    47881 tcactcttcc ttttacaaaa ttcattccat tataccattt ttagagacat ttgacgacca
    47941 taaaaatacc ttgtttggat tttgcataag aaaaagaggt tcccctcttt ttatgatttt
    48001 ttacaaaaga tttccttggt tccataggcg accagaacga gctccagtgc tagaatcact
    48061 tcaaccaaga ctggatttgt caaccagcct acttggaaaa gagatggtgc cagatcaaag
    48121 aaggcatgca agccataggc tgttaggaga taaatccatt tcttctggcg aacagcttga
    48181 taaacccaaa ctgtcaaaag taattggaaa ccaagcgcca agattcgctc aaaaccaagc
    48241 aaataaatct gccagaccga aagtgactga atggttttta acatattttc agacagtaat
    48301 tgcataacct gtggattctg agtttgaact gccgaaagaa caatgtaaag attgagtaaa
    48361 ctagtaaggc ctagaaaaat caactccaag ccaccatgcc ccaatccata ggccaaggcg
    48421 tctgcctttt ccaaacttct ctttttctcc aaccatttga agaaaacaag acgagccgtt
    48481 tcctcaaaaa atgctaccat ggctaggcca tagataatat agataagcgg atgaacttac
    48541 aagagggcaa tactaccgtc tttttgagga tgcaaaatca agatatgcac cagtttttcc
    48601 aaaatctgcg aagagacaaa gaaagcgact gcacccaagt ccaagacagc tagattaatc
    48661 tggtatttct ttttggcaaa ccaaatgctt cctatcagaa aagctagcaa cagcaacatg
    48721 gtaataatga tatgaatggt cattttcttc tcctattctg ccttttcaat atcttttttc
    48781 atctcgtcaa cattgaactt agcaaacaag tattgacggt cttggactgg gaaacgttgg
    48841 tccaactggt caattgctcc cacctcgata atgccttcct tgatgacaaa atccatgaca
    48901 tgtccaccga aggtcaaatc atctgatatg aagtgcagat ggtagcctgc cacactgacc
    48961 ccatggaaaa tctcaggcgt ccagaaacca acaatagtcc ccacaacatt gtcacgacta
    49021 tattccggtt gatgggttgc gacatcagca aacttggtat cgggtgttga cttaggaatc
    49081 atacgcacat gcatatgtga aaattccccc cgaatcttga tagagcggaa aagattttcc
    49141 ccatcataat aagactcaat tcgttctttc aattccttgt ctgtcatctc aaagcgctgg
    49201 cggaaaatga cctctgcctg atgcggtacc actgcagcgt aaggaataag ggcatctggt
    49261 gacacttcca caatttctgg ctggtctcct gaccctttgg cctgataagc cttgccatcc
    49321 aagacaatca attccccatc aatggaatcc aaggttccca aaccaaggtc accatgttct
    49381 agcaattctc ctactgtcat agtaccacca taaaggccag ccatcaaggc tccaagggta
    49441 ttgtattgaa ataatttcac tggttcctgc acgttcttat ccattcactt tcttgtctgt
    49501 tattctataa atcttactcc taagtatacc acatttgccc ctagatgtga acgagagaaa
    49561 cgctctagac attgccaaga aggaaaaaaa agggtacaat gtaacaaaat caagggaggt
    49621 ctggaatgaa gaaacaaagc aagtacaaag aggtcgtttc ctatctgaaa aatggtatcg
    49681 agtctgaacg atttccgacg ggtagtcgcc tgccttctat ccgtcaactg agccttgact
    49741 ttcactgcag caaggacacc attcaacgag ccctgctgga attacggcac gaacaatacc
    49801 tctatgccaa gccccagagc ggctactatg tcctagaaca agggcaacat caagacctag
    49861 aaatcgaggt taccgacgaa catgccagtg cctatgacga tttccgactc tgtgtcaatg
    49921 aaaccttgat tggacgagaa aactacctct tcaactacta tgacaatcaa gaaggattag
    49981 aagacctaag acagtccatt cacaaactcc tatttgagca agctctctac tgcaaggcta
    50041 accaactagt actgacttct ggaacccaac aagccttatt tatcctctct caaatatcct
    50101 ttcctagaca agccaaggaa atcttggtgg aacagccaac ctaccatcgg atgaatcgcc
    50161 tcttgattgc acaggggctg gactatcaaa cgattgaacg aggcattgat gggattgact
    50221 tggaggagct ggaaggccac ttcaaaacag gaaaaattaa gtttttctac accattcctc
    50281 gatttcacta tcccctaggc cattcctatt ctgagcagga caaacgagct attcttgact
    50341 tagcagccaa atatagtgtt tatatcgtcg aagacgacta tctgggggat ttggactcta
    50401 aaaagggcca gaccttccac tatctagata cagaggaacg cgtcatttat atcaaatcct
    50461 tctcaaccag cctctttcca gccttgcgga taacagcact cattcttcca aatactatca
    50521 aagaagcctt cgtggcctac aaaaatatcc tagactacga cagcaacctc atcatgcaaa
    50581 aggccctgtc actctatatt gacagtcaat tgtttgaaaa aaatcgtttg gctcgcttga
    50641 ccaatcatga atcttaccaa aaacaaatcg aggaaaggat aactaaaaca ccttgtcccc
    50701 ttcctcatta tcccctacac gatggtttat tgctagacct gagacagtat cctaaaatcg
    50761 ccagtctcaa acacagtcaa ctgggcttgg acttctttga agaggcctat ttaagcacct
    50821 gtccttatca atttgccaag gtgtccctag acaatctgga aaatgtttta aactatttaa
    50881 aagcagaatt ggaatgacat ccaactctgc tttttcttat tcttcaactt cagttaaact
    50941 tgctgctttt tcaagatagc tttggtaagt tccttcatcc ttaagttttt ggatgacctt
    51001 gtctaccact tctttcaaat catcactatt ttttctaaga gcaacggcat tggcgtcgcc
    51061 gtccttcatc ttcaagctga cagttgcgac agctaagcca gcgtttttag cagcataact
    51121 aagtgcaaca ggctcatcca tatgaacagc atctattttt ccagcctgca attcattgac
    51181 tgcttcaccc atattagtta gggaagttaa ttgagctttt ggcaattgtg ccttgaccat
    51241 tgattctgga acagtccctt tttgggctgc aatattagca ctttctaggc tagttaaatc
    51301 cttgtatttt tccacatcag ccttacgaac caagaaacta atcttgtttt catagtatgg
    51361 gattgaaaaa tcaaagactt cttttctctc gtcagtagca ctaattcctg caactgctag
    51421 gtcagcctta ccagtttgaa gactggtcaa aacattgtca aaactcatgc ttaagatttc
    51481 caacttaacc ccaagttcat cagcgatagc ctgagccatg tcgatgtctg caccgactac
    51541 ctggttcttt ccatcaacca atgattgaaa ttcaaagggt gcatagtcag gactggttgc
    51601 cacaactaat ttcccttttt gtttgatagc atccacagca gactgagaac cattagaacc
    51661 tgactggcaa gctactaaga agaaacttgc aagaaaatta cataaaacaa atatccattt
    51721 ttttgatttc ataaataaac aacctctctg ttaattttgt ataattataa cgatatccaa
    51781 gttacttgtc aagtgttttt taaattttta tctcaaaaat attttttcgt tcaaaaaaag
    51841 gagccatcag ttgatttcaa gctccttttt atacagaatt aaactatttt atagttcgac
    51901 aatcttacct gtttcaaagt agacaaccca ttcacagata tttttagcat agtcaccgat
    51961 acgctccaag taggaaataa cttggaaata atcacgaccc gtaacaatgg cttctggatt
    52021 tttcttaatc tcttcagtcg caaggtcacg gatagtttca aaatagtggt taatttgctc
    52081 atccatggag gccacccggt atgcgtcgtc aacagaacca ttaagataaa gatcaagtgc
    52141 tgcttcaaca acgcttttaa cttcacgtcc cattttttta atttcttcct ctacagctgg
    52201 aatgcgctct tcccccttca tacggatggt tgcctgggca atggctacag cgtgatcccc
    52261 catacgctcc acatctgata cagccttaag gacagtcaag actgtacgca aatcttgaga
    52321 gactggttgt tggagtgcga tcatttcaaa tgatttcttt tccagtttca cttcgtattc
    52381 atttacttct gcatcatctt cgatgacctc ttttgccagg tcacggtcat gcgtgacaaa
    52441 agcacgtacc gtacgattga tttgtgagag cacttcttgt cccatagcgt agaactggtt
    52501 atgtaatttc tctaaatctt cttcaaattg agatcgtaac atctttcatc tccttatcca
    52561 aattttcctg taatatagtc ttccgtttcc ttgtgttggg gatcaaggaa catctgcttg
    52621 gtatcattaa attcaatcaa atctccatct aggaaaaatc ctgtcttatc agagatacgt
    52681 gaagcttgct gcatggaacg ggttaccaga agcatggtgt acttgtcttt tagaccatac
    52741 aaggtttcct caattttacc agctgaaatc ggatccaaag ccgaagttgg ctcatccaag
    52801 aggatgattt taggactagt tgccaagaca cgggccacgc agacacgctg ctgttgacca
    52861 cctgacaatc caatagctga atcatataga cgatccttga cctcatccca gatagaggca
    52921 ccttgcaagg ctttttctac ggcttcatcc agaacctgct tatccttaat tccattgata
    52981 cgaagcccgt agacaacatt ctcatagata gtcataggga aaggattagg ttgttggaaa
    53041 accattccga tttccttacg taattcaacc gtatctgtac gcggactgta gatgttgtgg
    53101 ccattgtaca ccacggatcc agttgtggtc acctctggat tgagatctcc catgcggttg
    53161 agagacttga ggagggttga cttccctgat ccagatggac caatcaaggc tgtaatttcc
    53221 ttaggttgga aagataggga aacactattc aaagccttct ttttattata ataaacggac
    53281 aggtctgata cctgtaaaat cgcatctgtc atacggtttc ctttctaacc aaagtgacca
    53341 gatacatagt cattggtgga ctgtagcttg gcattttgga aaatagttgc agtcttgtca
    53401 tactcaatca aatcacccaa gtaaaagaag cctgtatagt cacttgcacg agcagcctgc
    53461 tgcatattat gcgttacaat gatgatggta aagtttttct tgagctcaaa catggtctct
    53521 tctagttgca tggtcgcaat cggatccaag gctgaggctg gctcatccat taagaggata
    53581 tctggcttaa cagagatggc acgagcgata cagagacgtt gttgctgacc acctgataag
    53641 gtcaaggctg acttgtggag atcgtcttta acctgatccc agagggcagc ctgacgaagg
    53701 gaggtttcta cgatttcatc taggacttgc ttatccttaa ctccagcacg ttcatgcgca
    53761 aaggtaatat tacggtaaat tgacttagca aatggattgg ggcgttgaaa aaccattcca
    53821 atgtgtttac gcatttcata aacgttgatt tctggacggt tgacatcaat tccacgatag
    53881 agaatctgcc cagttacttt agcaatatca atagtatcat tcatgcgatt gagactgcgt
    53941 aagtaggtag atttccccga ccccgacgga ccaatcaaag ctgtaatttt atttctttca
    54001 aattgcatat caatcccctt aatggattca tttttaccat agtaaacatg gacatcctta
    54061 gtagaaaggg ctactttttc ttcaggaaag gtaaggatat gcttctcatc ccagttatat
    54121 gttgacatgg cttctccttt aggcagcggt taatttcttg tgtagatagc ttccgaactt
    54181 acgagctcca aagttaaaaa tcaggataaa gatcaggagc acagcggcag aacctgctga
    54241 tacaatggtt ccatctggaa tagtgccttc actattgact ttccagatat ggacagccaa
    54301 ggtttctgct tgacggaaga tagagatggg gctagtcaca ctgaggatat tccagttaga
    54361 ccagtcaaga gctggcgccg attgccctgc tgtatagatc agagctgcag cttcgccaaa
    54421 gatacgacca gatgccaaga cgacacccgt tacaatacct ggaagcgctt ctggaataac
    54481 aacatgaacc actgtctccc agcgagaaat cccaagagcc agaccagcct cacgttgggt
    54541 atggtgaacg tgtttcaaac tatcctctac attacgcgtc atctgaggca aattaaagac
    54601 tgtcaaggcc aaggcacctg aaatgattga aaatccatac tcaaactgga ctacaaagat
    54661 caagtaacca aagagaccca ccaccactga tggtaaagag gacaagattt caatacaagt
    54721 ccgcacaaag ttggtaacag gacctttttt agcatattca gccaagtaaa tcccagctcc
    54781 catagaaaga ggtacagaaa taatcaaggt aatgaccaat aggaaaaagg aattgtaaag
    54841 ctgaatgcca atcccaccac ctgcttgaaa agcagaagac cttccagtca agaaagacca
    54901 agagatatgg ggcaagcccc gaaccaagat atagagaatc aaggaagcca agattgtcac
    54961 aatgatgcta gcaatcgtat agaggacagc tgttgcaagt ttatctaatt tcttagcgcg
    55021 cataattttt ctttcctctt tctttcgtaa tcaatttaat cacactgtta aaaactaaac
    55081 tcatcaagag cagtaccaag gccagtgacc agagaacatt attatttaca gttcccatga
    55141 cagtgttccc aattcccata gttaatatag aagttaaagt tgcagctggt gtggtcaagg
    55201 aagttgggat aacagctgag tttccgacaa ccatctggat agctaaagcc tcaccaaagg
    55261 cacgcgccat cccaaagacc actgcagtga aaataccaga acgggccgcc ttcaagatca
    55321 cacgccagat agtctgccag cgagtggctc ccatagcgaa acttgcctca cgataataac
    55381 gaggaaccgc acgcaagcta tccgttgtca taaaggttac ggtcggcaaa atcatgacaa
    55441 agaggacgga aatccctgac aaaatcccaa aaccagtccc accaaagaca ctgcgaacaa
    55501 agggaacgac gacttgcaag ccaataaatc cgtacactac tgaaggaatc ccaaccagga
    55561 gttcaatagc tggttgcaaa atcttcgccc cttttggtga tacttcggtc ataaaaactg
    55621 ctgcaccaat agcaaagggt gttgcgataa gggctgagag aatggtaacg ataaaggaac
    55681 ccaaaatcat aggaagggca ccaaattctt tactagaagg attccaagtt cctcccaaaa
    55741 gaaagtcaaa gatattcaca ccattgacaa agaaggtcga caagcctttt tgcgctacga
    55801 aaaccaaaat catggccaca aggatgacta tcaaagaaag acaggcaaag gtcaaacctt
    55861 ttcctaattt ctccagacga gaattctttg atggaagcaa cattttctta gctaattctt
    55921 cttgattcat tattgtctcc cttccaacac tgtcacagtt ccggcagcat ctttttcaac
    55981 cttcatttcc ttaatcggaa tatacttcaa tcctttgaca atcccttctt gggtctcatc
    56041 cgagagaaca aaattgagaa attctgcagc caactcattg ggctgcccca atgtatacat
    56101 atgctcataa gaccacaagg gccaattatt gctacttata ttttctggac ttaagtcata
    56161 gccattcaac ttcatgcttt tgaccgaatc atctatatag gtaagagata aataagagat
    56221 agctcctgga ctttttgata cgattgattt taccgctcca tttgaatcct gctcctgact
    56281 ttgcatggca gactgacctt ccataatgac agtatcaaag gtagcacgag agccagagcc
    56341 ggctgcccga ttgataacag agatgggtaa gtccttacca ccaacctctt tccaattggt
    56401 tacctcacct atgaagattt gacgaagttg ctctgtcgtt aggttatcaa catcaacctc
    56461 cttattgaca atcagagcca agccagctac cgcgaccttg tggtcaacaa gagcagaagc
    56521 atcaattccg tctttttcct cagcaaatac atctgagttt cctatatcaa ctgccccaga
    56581 ctgaacctgg gacaagcctg taccagaacc tcccccttgg acattgaccg tttttccaac
    56641 atggatcgtg ccaaattcat ctgccgctac ttcaaccaag ggttgcaagg cagttgagcc
    56701 aacagccgtt atggattctc cacgatcaat ccagctagca cagcctacta aacaagccgt
    56761 cagccaaaaa gcgataagag acagagcaag cttttttctt tttttcactg tttttctcct
    56821 cgaaaataat tatgaatact gtgaattttt taagtagttc tttatgagtt gacgcatgaa
    56881 ttcttaccaa atttctgcgc aattgattat ttatataata taggctatat tactctttcc
    56941 taacctcctt ttttcatatg tggataaaat ctcttgtcta tcccttcccc cattgtcacc
    57001 cattatagtc atttcgtgtc tctttttccc ctttttaatg caagggaaat tactctcctt
    57061 agatgataat ccaaaagcta gaaaggtatc tcaaacctct ctactctccc agactagttt
    57121 acaactaaaa ggaaaagatt ctattttatg agaaatctag tttacaagcg gtaagaacgc
    57181 taataactaa acttcttgta ctctttgaaa atctcttcaa agcagtgttt tgagctatct
    57241 atggctagct tcctagtttg ctctttgatt ttcattgagt agtaaaacta catgtaatgg
    57301 caatcaagat atcaagaatc atcctactaa aaaaatccat actttcacta taacatagaa
    57361 taagatattt gactagcatt ttcatttgaa tctgaggcct tttggaaaat aatttttcaa
    57421 aacatttcca gtaacctttg caaagcccaa gccattgcct ttaaccaaaa cttggtacca
    57481 accatttggc agactttctg ccagctgaac gatttctcca gccgcatact tgacaaacgc
    57541 ttcttggcca atttcaaccg actgttcgac ctgactcgat ttcaaggcta aaccaagagc
    57601 gaaactgggc tcaaagcgtt tcttcttaaa agtacccaga tgcagtccat tgcgagcaat
    57661 cttgagcttc cctaaatctg gcaaaagttc tggcaagaga taaagctggt ctccaaaagt
    57721 ctgcaagata cccggtagat tgaccttcaa atggttttgg gcaaattcct gccacaaggc
    57781 aacttgttca cggctgaggt tactcttact tgccttaaat ttaggagctg gattgttacc
    57841 cttaaactgt agatgggcaa caaactgacc ctctccctta aactgatgag ggtacatccg
    57901 agccgtttct ggcaggtcaa taccagctac cattccattg atatgctcta ctggcaacaa
    57961 gtcaaaatca tactcttcca gcaaccaatt gacaatctct tcgttttcct cgggtgccca
    58021 ggtacaggtc gaataaacca gacgaccacc ttcagctaac atggtcactg catcctccag
    58081 aatttctctt tgcaagctag cacattgact cggataatgt aagctccaat agtccatagc
    58141 atcaggttgc ttacgaaaca ttccttcacc agagcaaggg gcatcaagaa cgattaagtc
    58201 aaaatagcct ttaaagacct tgaccaagcg gtcggcagat tcattggtca ccacgacatt
    58261 tgtcgctcca aaacgctcca tgttttcaac caaaatctta gcccgtttgc ttgaaatttc
    58321 attggaaaca agtagcccct cccctgctag ataggctgcc agttgagttg atttgccccc
    58381 cggtgcagca gccaagtcca agaccttcat accaggactg ggttgggcta cttgagccac
    58441 catttgagca gcaggttctt gcgaataaac taaacctgta gcatgctcag gcgatttccc
    58501 tgaaaccttc ccatagtggc cccaaggggt ttgagtaatg gcatcagaaa aggaaagttg
    58561 ctcttctttt aagggattga cccgaaaggc cgaaaccgct tcctcctcaa aagaggcaag
    58621 aaaatctctt gcctcatctc ctagtatttc tttatatttt tcaacaaatc cttctggaaa
    58681 tttcatttaa gttcttttcc tttcgtaaat ataggactga atttcctcct gcatctcaag
    58741 aggcaccatc atgaccggct gtctggtttg aaaatcagga gcttcaccaa aaagggtcac
    58801 aacccgatag cccagacttt cccctaaaat actagctgcg gcataatccc atggttgcag
    58861 ataggtgaga taggtcaaca aatgccctga caaaatcttg gcaaaactaa tggccgcact
    58921 tccatagata cgaacaccaa gaaccgctcg gctcaaatca gccagccccc attcattggt
    58981 ttccagcata ccactattcc ctgcaatgag aaaatctcca agtggtttag ttttaaaagg
    59041 agctaggggc ctatcattta gacaaactgg aaattcccca ccaccgtggt aacaatcccc
    59101 tttgaccaca tcataaatca gaccaaactg tccctgacca ttttcaaaat aagccatcat
    59161 aacagcaaaa tcttcctgct gggctacaaa attattggta ccatcaatgg gatcaatgac
    59221 ccaaaccttg ccctcttgaa ccgaggctcg cagacaacct tcttcagcac aaatcttatc
    59281 ctcaggataa cgggacaaaa tctcaccaac caagagttcc tgaacttctt tatccagtct
    59341 ggtcaccaaa tctgttggag aggacttggt ttcaacacgc aagtcttcct gcatatggtc
    59401 aagaatgtac tgacctgctt tcttaacaag ctctttagca aattcaaatt tactttccaa
    59461 gagaaatctt tccttcccct ttttctttgg cagcctgaac tgctcggtaa agtgaatagc
    59521 cactaaccgt ttcaaattct cgtcccaaac gtttctcttc gctcttgctt ggcacgaccg
    59581 ctttgaatcc cttataggag tccagtaact ttttagcctc tactttgcct tcataggcag
    59641 cttcaacatc attaaaaaaa gaaagcactg aagcaagttc ttcagtgctc cacgacaaat
    59701 ctagtgggta actatactgt ttgttcatta actaatacca gctctcattc ttgcttcttt
    59761 tagttcttgc ttacgataac tacgagggag aaaagcacga atctcatctt cattaaaacc
    59821 gatttgcata cgcttggcat caataataat tggacgacgc aaaagactag gatactgctc
    59881 aatcaaatga agcaattccg ataccgaaat actctctaca tcaatattca atttttgaaa
    59941 aatttttgaa cgagttgaaa tgatgtcatc agtaccattt tcggtcaagg aaaggatgtg
    60001 ttgcaattct tttcttgtta aaggactggt cataatattg tgttccacaa agggaacctt
    60061 atgtttttct aaccaggcct tagccttacg acatgatgta cagctcggtg atagaaatag
    60121 tgtaatcatg cttttctctt cttatctata ctttgctact tctattatac aaaaaaataa
    60181 agcgcttgac tagggatttt tagaaaaaaa gcctattttt tcaagaaaaa taggcttttt
    60241 gcgaacgatt gacacaattg gatttggtta attcactctt aacgatggtt ttaaacgata
    60301 tatattttta tatatgtaaa ttaaaaacat ctttcctttc acttcctacg acttttcaga
    60361 tacagatagc caaagaagtt ttcatagagg gcaaaaaaga ggaggaaggc atgaagaaag
    60421 aaggtctctg gcaaaatcat aataacagga tccttggctg gatcaaaaag ccaggtatca
    60481 tctcccacaa agagaatttg atggaaaaga gtaaagaatt ggtcaaaacc aatcaaaact
    60541 cccccaagtc caatcatcac aggtaagact actagagcca ggagactttt tcgataaaga
    60601 gacaaaaagt cctttttcac aatcctattg acaaagacat agaaacttgg cagtgtcact
    60661 agagctacta gctgaaccaa atgaaagaga ttcttgacca ctgcgaaatg gtgcagacca
    60721 gctgctgacg aacgaaaatc aggcatctgt aagacctgac taaaaggatt ggtcagataa
    60781 ttcatcaaga tatgaaaatt gtattgaatg gtttctggtt ttagatagac tcgattcgtt
    60841 aagtttagcc actgaatctc cataggatag aaaatccaag ccagataaat ggtcagaagg
    60901 attgagaggg agaggagaaa gagcatagag ccccaaaagg tcaatttagt tttcatcaaa
    60961 atcccactcc gcaaggctag aaaccacatg tgtcggtgcg attggcaggc cagctacttc
    61021 ttctgcctta gtaaaacctg tcgtcaccaa gagcgttgga atgccattgt caatcccagc
    61081 ccggatatca gtcaaataat tgtccccaac catgattaac tcttcacgtt ccaaacctaa
    61141 gtgctcaacc gccttgtcca taatgatggc attgggtttt ccgatataaa ccggcttcac
    61201 tcgtgtcgct acttcaagca gcgtaatcag ggagccagca cctggcaaaa gaccgcgttc
    61261 cgtcgggatg ttgaggtcag gattggttcc gataaaatgg gcaccctttt gaatagcaag
    61321 agttgctgtg gcaaattttt catagtcgac ttgccaatcc agaccaacta ccacgtaggc
    61381 agggttttcc ttgtcttcca cataaccagc cgccttgatg gcttccttga gtcctgcttc
    61441 tccgacgaca tagacggtct tttcaagccc caaatcattc atatagtcga tggttgccaa
    61501 agtcgctgtg tagacagtcg ataggggcgt atcgatatta aaattctgag ccaacatctc
    61561 cttaacactc tctggagtgc gagttgtatt gttggttaca aagagatagg gaatgccccg
    61621 cttttgcaat tcatgaacaa aagtctctcc agcagggatt cggtctttcc ccttataaat
    61681 ggttccgtct aaatcaatta aatagccttt atatttcatc tatttctccc taagcctttt
    61741 ttatttcttg ccaagtaatg attgcttggg cattgataac cccatcactt gtaatttcat
    61801 gcttgctttc cagtccagtc cgttcaacaa ccgatgtaat cactccacct ggtcgaactt
    61861 ccttgacata cttgaggttg attttcttgg gaatatagtg ggtcaaaaaa tccgctccca
    61921 tgacctcaaa aatccagtcc aagtatttac tgttattgac atgaccattc atatccaagt
    61981 cgtaaaaacg aacatggtaa tccttgctga tcggttcttc caaggactca tacttcggtc
    62041 cacggataag ttttttatca aaatcagact ggtaaggagc cacaatctca ggttcaacag
    62101 catggacttt tcgactgtcg cggtccatga gaacaaaggt cgccatcata tggatgagct
    62161 cctgccccgc ttcattataa atagtaaagc gacggtagca aaaaagtcga ttgtagctca
    62221 aggcttccgt ttcgatggta atttcttccg caaaacgagg caaacgaacc acctcaatat
    62281 catattctgc gataatccag accagattat agtcttccaa aatggcctta tcactaactc
    62341 ccagttcaat cgactgcatc cctgaaactt gcagtgacag caaaatcaca tctggaagtt
    62401 tgatatgacc gttcatatca gccatatcaa aaggaatttt cattttcatt tgataagtta
    62461 agcccatgat cctactccaa aataaatcgt tctgctacag tatctcccaa aaagagacct
    62521 ctctttgtca tgcgaacgtg gtcaccctca atctgcatga ggccttgttg aaccaaatct
    62581 ctgacaattt ctccataaag tccagcaaaa gactgtccaa atttttcctc aaatcgcgcc
    62641 atggaaaccc cggatttctt gcggagtccc aagaacattt cttcttccat ttgctccttt
    62701 tgactcaggt gatcttctgt aatacaagca ttgccttcct caaccgcact gagataatga
    62761 cgaatgggac catgattttt ataacgtact ccattgacat aaccagatgc ccctgcacca
    62821 ataccatagt attcagcatt gtcccagtac atgagattat gacgactttc aaagccgggt
    62881 ttggagaaat tagaaatctc ataatgctca aaacccgctc gctccagctc tgcaatgatg
    62941 tactcaaaca tctccgcttc tagttcctcc ttaggcagag gcaatttccc acgtcgcatc
    63001 cggttcataa agaccgtatg gttttctaaa atcaaactat acaaactcat gtggggaata
    63061 tccagtccaa tggctttagc cacattttcc tttacttgct ccatggtctg accaggcaga
    63121 gcataaatca aatcaatgga gatgttgtca aaaccagcca gtttcagacg atcgatattt
    63181 tcataaatat ccttctccaa atgactgcgc ccaatctttt tcaacatctt atcatcaaag
    63241 gtctggacac ctagcgaaac acgattgaca gccgaatttt tcaaaacagc tatcttatcc
    63301 gcatccaaat cgcctggatt ggcttcaatg gtcaactctt ccaagacaga caagtccaag
    63361 tttttagtca agccattcag taacacctcc agttgcggag ccgacagggc tgtcggtgtt
    63421 ccaccaccga tataaagggt tgacaacttt tcaatatcat aagaacgaaa ctcttccagc
    63481 agatgctcta aatagctgtc gactggctga tttttgatga agacctttga aaaatcacaa
    63541 taataacaaa tctgggtaca aaatgggatg tgcacatagg ctgacgttgg ttttttctgc
    63601 atagtaatta ttataccaca aagactagat tccagataaa aatcaccatc cccagataca
    63661 tagtccgtcc ggagatggtg atggtttatt cttctgttat atcaatcaca atctcttctg
    63721 agtcatcaag agcttcggct ttttcttgcc attgttcctt gagattattt aattgatttt
    63781 ttgatgcttc tgtcgcttga aaagcatagg atttagcttg agcaagtata ctgtccacag
    63841 tgatttcacc tgactcaacc tgttcttttg ttttcagaac aaaatctgta gcctgctcct
    63901 taacttctgt cagtttttca cagacttgct ccttggcata ctccggatct tctctcaaat
    63961 catctagaaa atcttgagcc tgactgcaaa cttgtttgcc cttatcactt gttaaaaaca
    64021 aggcaagagc tgcacctgaa accgttccta aaaggattga ggataattta cccataagga
    64081 ttctcctttt ttattttttg aaaaatttac ttgcaagacg aagagctgac agacttgcac
    64141 cagtcttgag tgtttttgaa ccagctgatg aagctttctt gctcaagaca cgcgcatggt
    64201 cattgaggtc tgaaacagat agagataaat ctgcaacagc actgaagagt ggatcaatcg
    64261 tagccacctt gacattgata tcatctgcca agacattgac cttagccaac aactcattgg
    64321 tgtgatgcaa ggtcacatcc acatctgaag tcaaggtttt aatcgtcttt tctgtttcat
    64381 cgatgacacg accaagcttt tgtacagtaa tgatcagata gaccaaaaag acaatcaaag
    64441 ctagggcaac aagaatatat gcaacttcta acatttattt ttcctcctct gtaatatagt
    64501 aaggggcctt ctttcgattt tgataaataa cgatcattat accgagaccg ataaggacaa
    64561 ctgacagcca ttgggacact cgaaggctga agaacatgag actatctgtt cgcatacctt
    64621 cgatgaccat acgaccgaaa ccataccaaa tcaagtaaaa ggccgtgata tgacctcgtc
    64681 tgagactctt ccatttccgt ctaaaaatca gaatcaaagc aaagccaagc agattccata
    64741 gagactcata aaggaaagtc ggttgacggt agctcccctc aatatacatc tggtcacgga
    64801 taaagccagg tagataatcc agattatcca ctgttgcacc ataagcttct tggttaaaga
    64861 aattacccca acgccccaaa ctttgagcaa tcataacgct aggcgccgca atatctagaa
    64921 aatcccaagt attgatgagt ttacggtcag caaagatata gagcacaaga gccccagtta
    64981 tcaaaccacc gtaaatggcc aaaccaccat tccaaatggc aaaaatctct cctaaattct
    65041 gactatagta atcaaatcgg aaaataacat agtagagacg agctcctaaa atagccaagg
    65101 gaaaggctac taagataaaa tctaaaatat cgtctggtat gatcttcttt ctaggtgctt
    65161 ctttcatggt caaataaacc gcaagaatca agcctgtcac aatacataag gcataccaac
    65221 gaatggctag gggtcctagt tgaatagcaa ttggatcaag cattttgcac ctcatttcga
    65281 gcaatgagac ttgtcagtcg ttcgtcgaac aaacgggtcg catcaaagcc catttccttg
    65341 gcacgataat tcatggcagc tgcctcaatc acaacagaga tattacgacc tgttttaact
    65401 ggaatacgaa tacgaggaat ggctacgcca gaaacttcaa gttcctctgc attgtttcca
    65461 agacgatcaa aggtcttatg tgtatcgtaa ttttccaaat agacagcaag ctgaacctgt
    65521 gaagaatcct tgacagcact cgcaccgtag agactcataa catcgataat accaacccca
    65581 cgaatttcaa tcaagtgttt caaaatttca gctggttcac cccagagagt aatctcatcc
    65641 ttggcaaaga tatcgacacg gtcatcggct accaaacggt gaccacgttt gacaagctca
    65701 agacctgtct cgctcttacc aattccacta tctccctgaa tcaagacgcc catcccataa
    65761 atatccatca agacaccgtg cacactggta cgttctgcca aacgagaatc cagatagcta
    65821 gataactctc cagataaacg actggtagct gcacggctgg ttaaaatagc aatcttacat
    65881 tctctagcag cctttaacat ctcctctgga accaccaaac cacgggcaac aatgactgct
    65941 ggtgtctcag gtagaaacat ttttttcaaa acttcataac ggctgttgga aggcatgctg
    66001 atcagataag accactcctt catccccaaa agttgaatcc gctctggtgt atagtagtca
    66061 aaatagcctg tcatttcaag accaggtcgc gtaatatccg ctgtattgat ttccttttca
    66121 agcaattctg gttcaccata gacaatatct agtctaagct tttcaatcac ttcttttact
    66181 aaaaccgaca tcatttcctc cttcaaatga gttcttctct ctattatatc aaattgtagg
    66241 aggaagtttc agatttttgc aggctttgga gtatttattt aaaagaaaaa ggactagatt
    66301 tctctagcct ttcatttcaa ttagaatttt ttacgtttac gagctacttc tgatttacgt
    66361 ttacgtttta cagaaggttt ttcatagaat tcacgtttgc gtgtttcttg aagagtacca
    66421 gctttagtaa ccgcacgttt gaaacggcga agtgcgtcgt caagagattc attcttacgt
    66481 actactgttt tagacatttt tttcactccc ttcaagttca atatctattt cattctacac
    66541 gtaaaaggaa taattgtcaa gcaaaaatgc ggtttaattt tgattttttc ttccatttat
    66601 acaagagttg aaagcgttca atagaacatt gcttttttat ttttcgagta agctaagcgc
    66661 ttcagcatct gcgatgatgg ttacatcagg gtgattttgg aggctacttg caggtaggtt
    66721 ctcagtcact gggccagata ctgttccggc aatggcttct gctttcgact caccgtaagc
    66781 aaaaagaata atagacttgg catccaaaat gtttttaatc cccattgaaa tagcttgggt
    66841 tgggacgtct tcaatcttgg caaagaagcg tgcattggct tcaatagtag actggtcaag
    66901 ttctactaga tgcgtttgac tgtcaaatgg agtaccaggc tcattaaagc cgatatgccc
    66961 attgcgaccg attcccaaga tttggaggtc aactggatgg tcagccaaaa tttggttgta
    67021 gcgttcaact tcagcttcag cattgtcctt aacaccacga ggcaagaaac tttctttaaa
    67081 tggtttttgg ttgaacaagt tttcttgcat gaagtaacga taagactgtg gattgtcccc
    67141 atcaaggccc acatactcat caaggttgac actggttaga tttgaaaaat caaggttact
    67201 ctcaacaatt tccttgtaaa attcaagtgg gctacttcct gtcgcaagtc ctagagtttg
    67261 agctccatta gccaattttt ccttcaaaat ctcaaaagca acttttccac cttgaacttg
    67321 gttttcaact ttaataactt tcatcttttc atcctccatt tctatctata tttattatat
    67381 ggtatagacc aatttttgtc aagtgaaaac gatttaattt ctaaaaaaag agcgtccaaa
    67441 cttgaaacgt gttataatgg ataggattag aacttagaaa gaatgaacag atatatgaat
    67501 acagctgatt ttgatttcca cttgccagag gaattaattg cccaaacgcc ccttgaaaaa
    67561 cgtgatgcct ccaaactcct catcgtcaac cgtgagacag gagaaatgca agataaacac
    67621 ttccactcta ttattaatat gctggaacct ggtgatgccc ttgtcatgaa cgacacccga
    67681 gttctccctg cccgcctcta tggtcaaaaa gtggagacag gaggtcatgt ggaacttctc
    67741 ctccttaaga acactagtgg agacgagtgg gaagttctgg ctaaacctgc caaacgcctc
    67801 aaggtcggta ctcgtatcag ctttggtgat ggtcgcctca gcgctgtcgt tacagaagaa
    67861 ttgacccacg ggggacgcat tgtccgcttt gaataccaaa gaattttcct agaagtcttg
    67921 gaaagtctgg gagaaatgcc tctgccacct tatatccacg aaaaattaga tgaccgtgaa
    67981 cgttatcaaa ccgtctacgc caaggaaagc ggctctgctg cagcaccgac tgctggtctt
    68041 cacttcacca aagaactgct ggcagaaatc caagctaagg gtgttcatct agtctatctg
    68101 actctccatg tcggactcgg aacctttaga cctgtttctg tggataatct ggacgaacac
    68161 gaaatgcact cagagttcta tcaactttct gaggaagctg ctgccaccct tcgctctgtc
    68221 aaaaaaaatg gtggtcgtgt catcgctgtc ggaaccactt ctatccgcac cttggaaact
    68281 attggttcca agtttgatgg gcaaatccaa gcagattctg gttggaccaa tatctttatc
    68341 aaacctgggt atgagtggaa ggtcgtggat gccttctcaa ccaacttcca cctgccaaaa
    68401 tcaactctgg tcatgttggt ttctgccttt gcaggccgtg aattagtctt agatgcatac
    68461 caccatgcca tccaagaaca ctaccgcttc ttcagttttg gtgacgccat gtttatttat
    68521 tgagaaagaa tttctctaaa tcttctaata ccaataaatc gctaagatat tatttcaaag
    68581 aacatctaca attgaaactc tagctagctg tagaagaggc ctagtacatt gaaattaaaa
    68641 tgcttccccc tagcttcgaa aatattgcca tagattgcgt tgactctcca aattgattca
    68701 tctatatttt atttcagctt cctatacttt cttcgctgtt tgtaaatcaa aatgcaagac
    68761 acatgagtag caccatattt gttactctta tctgtcctct caagagacta ttatgagtta
    68821 tttcagaatc attcactact ttgaccctga ctctccttag tctcaaaatc aaagacttat
    68881 actcttcaaa aatctcttca aaccgcgtca acgtcacctt ggattatata tgtgactgac
    68941 tttgtcagtt ctatctacaa cctcaaagca gtactttgag caacctgcga ctagttttct
    69001 agtttgctct ttgattttca ttgagtatta aacaaaaagt gaacaaagct gaattctaat
    69061 gtacagaaga ctaggcttgt tcactttttt atagtcgcta taagatgacc ttatctatag
    69121 ctttttatat ataattatat attcagacat actattatca attttgtctc agggaggaat
    69181 ctgttaacgc acccattcac cattatcatt gactctatag ccatctatac ttgtattgac
    69241 cgctaactca cccgatgcat ttacataata ccatttacca ccaacttgga accattgatt
    69301 aactttcata gaaccgttgc tgttgaggta gtaccatgaa ccattaactt gtacccaacc
    69361 tgttgccatg gaaccatcag tattataaaa ataccacata ccattttctt gtttccagcc
    69421 tgttgttgga gcaactgctt tagctggttc tactgctaca tctgttcctt ggttagatgt
    69481 aacagataca ggatacgaag gaatagatga ttgctcagga acaacaactt tttcaggttc
    69541 tctcgtccct ctccttatac gtctttttac catctcttta gtaatttgac gagaagtagt
    69601 ttcttcaatt gttccatcac gttcatctac agcatagatt gtagtaagag taattttacc
    69661 aatttctcct acttcttgac ctttatcaag agttgggtca tcgagatatt ctgtttcgat
    69721 tggaatttct tggacaagaa cttggggctt ggttcctttt ttaacaactc ttgtttgaga
    69781 gtcttctttt tgacttaaag tactctcagt tacttgtcca ctctttccat ctacatcata
    69841 agttatcgtt gtaactgttt tcccattctt tcctagagta atctcttgct cctgtcctgc
    69901 agaaaggtca ttgtctgctt catatttagt agcacatgga acaagaactt cttcaacctt
    69961 gcttttagct ggaactttga taactgtatc cgtggcttct tttctatcaa cagtaacctg
    70021 ttcggtaaca tgaccagtct ctggattaac atcgtaggtc cttgtcgtag ttacatagcc
    70081 atcctctcca tcaattgtaa caggattttc actacggtct tttgtttcat ctttttcata
    70141 acgaattcgc gtacttgaaa ttttcttggt tactacctta ggtttagtcg ctacttttac
    70201 aataatatcc ccattgtcag cgtcatcata ctctattccc tcttctttat ctctagtatc
    70261 atctctgaca tattgaatcc catcagcagc atgaacaaaa cttgtattca gattcctcct
    70321 aaaaataaag ttagcccgat taccgcagaa ccaaaaatct ttccgagttt acgtaatgca
    70381 tagcgcttat tggtattaga ttttgccatt acatcctact tctaaaagtt actacttcta
    70441 gtatagcatc ttttctatca aacgttaaac agtatacttt atatatcaaa tatacttaga
    70501 atgatatatt gattattgaa ctaacgcttt aactatatcg taatcaatct catatataaa
    70561 ggattgcaga catcttatct aaatacatgc taatatattt agatacaaac attccaactt
    70621 gataactttc actcatcttt catcattcct tatacaacta tgcagtataa atagaatagt
    70681 tttctcatca gaatgagact attttaatat tagatatttt gatagaaaaa acatgaataa
    70741 aattggttga atttaattcc ctaactcgat agaggattct attttaaatt taacaacagc
    70801 taggattaca ctataaaaag tacattacca cctgttcggc tggagaatct agtcgattag
    70861 ctccctctta gttacaagct taaagcgatt ttttaactaa tactaaacca gattaaagaa
    70921 ggaactagaa catctgtctt gtactaatca atatgctatt ttaaagttgc aaataaactt
    70981 ggaatgctaa ttattatatt tacaataaat agttgacttc gatagaaaca gaaaatagaa
    71041 ttcaacattc ttccctactt ataccataat aaataagatc cgcaagatag ccttttctct
    71101 ctacaccatt aacaatggtt tgtagatagg acattccagc cttttccatg acacgacctg
    71161 aagctgggtt gagactggca taacgtgctc tgaccttttg aaaacctgct tgagtaaaac
    71221 aaaagtccaa gatagctttc aaagtctctg tcatcatacc atttccccag taagccttgc
    71281 ctaacacata gccaatttca cagcttaaat cagcctcgtc tatcttaaca atgctgatat
    71341 ctcctatcac ttgctctggg ttttctttta gacaaatggc ccatttataa tagttgagat
    71401 tagtatagga agcaacccaa ttgcaaatcg agtttcgagt gatttcgaca tcaggatggg
    71461 gatcccaggt aacataggtc agattctcag cggatgaagc ccaattttga aacatggctt
    71521 ctgcatcact ctccacaaat cttcttaaaa tcaaacgttc tgtctgtaat atttgcgtac
    71581 cgatagattt catgatgcta cctcacttcc ttatttctat gctcgtagta aaaaggctca
    71641 actcagtaac agctagaaaa cgagtttgtc ttctaatttc ttgacgcagt cgctgcctgg
    71701 tttgaaatgc gctctagcaa tctttttcaa acctagtcat cgttgcaggg gtaagacgat
    71761 gaaatcgaac tcttcgagtt accgaatctg cctcattttc ttatttcaag atgagaggct
    71821 gaaaacctcc agtggaggtt tttcttgctt tttaatttca gggcaagaag ctaaaaaggt
    71881 cccccggacc ttcttcgctt tctcatttct aggctcaggg taaaaacctc caatggaggt
    71941 ttttactccc aaaagtcatc aaatacggtg atgggtaagt ggcgtttgtg ttggcctttg
    72001 tgccaccagt tttcaatggt cgcttgagct tctgggctga ttgttttgcc ttctaggtaa
    72061 tcgtcaatct ctgcataggt gactccaagt gcgacttcgt cagctaggcc tggtttgtct
    72121 tcttctaggt ctgccgttgg gattttttca taaagggctg ggtctgcacc aagttcctgt
    72181 aagagttgtt ttccttgacg tttattgagg cggtaaagag ggagaatatc cgcaccaccg
    72241 tcaccaaact tggtaaaaaa gcctgtgata ttttccgcgg cgtggtctgt tccaatgacc
    72301 gctccgctat gggaaccagc aagggcatac tgagcaatca tacggcaacg tgccttgata
    72361 ttccccttgt tgaagtctga aacaggacta cctgtcgctt caactgcagc tgtcatggca
    72421 tcagctgatt ccttgatatt cacaaccaag ctgacatctg gctggatgaa ggctagggct
    72481 ttttgagcat ctgcttcatc agcttgcact ccgtatggca ggcggacaac gataaatttg
    72541 tagctgtcgt ctcccgtttc agctcgcagt tcttccatag ctaattgcgc caaacgccct
    72601 gccaaggttg agtcttgtcc cccagaaatc cctagtacaa aggtttttag gaagggatgt
    72661 tttttcagat atctttttaa gaaatcaata gaacgacgga tttcttcctg ggcatcaatc
    72721 actggtttga cacccagctc ttggataatc gtttcttgca aactcattct tcttctcctt
    72781 caccaagggc ttccttgcgc atcttatcaa tcaagtccat cttatcttgc catacatcac
    72841 gcgccaaatc cactggatag tgctgcggat tgagcacacg cttatactca tcccacaact
    72901 tgtcaaattc cttacgggca taatcctgaa tgtcagtcaa actaggcaag ttgtaaacta
    72961 atattccttc tttgaagata tccaccaaga gaggaacggc atcaaaatta cgaaccgtct
    73021 tcttgatgta tgtataggtc ggatggaaca tcttgatttc tgtcatgtcg ctaatatcca
    73081 caccatcata agtgatatag tcgccttctg acttgccttt ttcacgactg gtaatgcgcc
    73141 acacctgctt cttacctggc gtagaaactt tttcagcatt attagacagc ttaatcgtat
    73201 tgcgcatctg accagtttca tcttcgattg caacaatctt gtaaactgca ccaagagctg
    73261 gctggtcata agctgtaatc agcttggtac ccacgcccca gacatcaatc ttggcctttt
    73321 gcatcttgag attgaggata gtattttcgt ccaaatcatt agaagcataa atcttagcct
    73381 ctgtaaatcc agcctcgtcc agttgctgac ggactttctt agaaatgtag gcaatatccc
    73441 cagagtcaat ccgcacaccc ataaagttaa tctgatcacc cagctcacac gccacctgaa
    73501 tggcagctgg tacaccgatg cgaagggtgt cataggtatc cacaagaaag acacaatttt
    73561 tgtgggtctc agcgtaagcc ttgaaagctt catagtcatt gccataaacc tgtaccaagg
    73621 catgggcatg ggttcccaaa acaggaatgt caaagagctt acccgcacgc acgttgctgg
    73681 ttccattggc cccaccaatc accgctgcgc gtgttcccca gatggccgca tccatttctt
    73741 gagcccgacg tgtcccaaac tccatcaagg gttcatcttc gataaccgaa cgaatacgag
    73801 ctgccttcgt cgccaccaag gtctggtagt tgacgatgtt caaaagagcc gtttcgacca
    73861 actgacattg ggctagaggt ccttccacct gcacaatcgg ttcattagca aaaaccaaat
    73921 ccccttcttg ggcagaacga acggtcaact ccaacttgaa attgcgaagg taatccaaga
    73981 acgccccatg ataaccaagc gactccaaat aggctatatc actatctgaa aaacgcaagt
    74041 cttcaagata gttcacaatt ctttccaaac ctgcaaaaac cgcatagccg ttcttaaaag
    74101 gctgttggcg gaaatacacc tcaaagaccg ccttcttatt gtgaatccct tggtcaaagt
    74161 aaacctgcat catgttgatc tggtacaagt ccgtgtgcaa tgtcaaacta tcatctggat
    74221 acatactttt cctacttcct tagctagaaa cccatgaaaa ttttcaagaa ctttcatgta
    74281 ttccaataaa ttagtactat tatatcacat tttagctgga ttgagaaaag agtaacaagc
    74341 tattctccac tctccaattc atccatatct tgttcaaatt ttttctgagc ccattcgcca
    74401 tagctcttaa gaccaagatt gccaataaag acccacggaa ggtaaatgac ataagtaatg
    74461 acccaagcag acaggtattt aaaattcaaa ggattgtgct gataaatttc tatgttgaat
    74521 tgataattct gcaacatcaa aagagccgta atagccaagg ttaggaaaaa acaacccaaa
    74581 atcgtaaaat gaaaacgact atagtaggtc actcccagat aacgggcacg attgaaaaag
    74641 taaaatgtcc ctatgatgat aacgattagc agcatattag aattaaaaag gcttggtgct
    74701 aatactgaaa tgatataaga taggagcgac aaagcgatgc agatatagaa actttcagag
    74761 cccgctttat tgaacagttg ttcttctctt tcgtctagta attgataata ataaaatcta
    74821 tttttcatct tcttcctccc aaaatagttg gtctagggtt ttccctaaac atctgcaaat
    74881 ggactggcag agcgagagac tgggattgta tttccccgcc tctatcaaac caatagtctg
    74941 gcgcgtcacc ccgacagcat ctgctagttg accttgagtt aaatcaagct ctacccgagc
    75001 taattttaat tttaaatttt taaccacctt cgtcctcctt ataattttaa tattcatcta
    75061 ctcttaaaaa attccaaact aacacaagct gtcagctatt tattataacc ccattaattt
    75121 gcactccagt attatcttca gccgaaaatc agtattttag gttgtttgaa ataaacttcc
    75181 tagtttactc ttttattttt atttagtatt agctttagta ggagctttta aacgagtttt
    75241 tattgcttat atttcttgtt tagtttagtt ggtttcatat cactattata taatgctttt
    75301 gaaaataagc ctagtataag tcaaaaacgt gttgaatagt gaaagcagga gcataccaag
    75361 atgactgatt tttttactgt attttaggta tgcaaaataa tactaaatga aactaaaatg
    75421 aatacttctt gcttttcttg agagtgaaaa agtacaataa aatgattgta gtgattagca
    75481 caagatactg actaatagac atcgtatttg aagtcacaaa tacaggtaaa gaataaaaag
    75541 gaagaagttc aattgctttg ataaacaaat cattactagt attcatcatc atcgtattta
    75601 atatattagg gataaagagt agtaaagcta ctaaaatacc aaataccaag ccacttttca
    75661 atttgtataa atagaaaatg taagataata gaaaataaaa caggactaac aaaattgtat
    75721 tgactacaat agctactata aaatctaatc ctaaatcacc tggaataccc aatttactta
    75781 ctatgactag taacacaatg ccattcaaag cataaataat ggaaactgag atggcatata
    75841 gaaaattaga caagacgtaa atcatccgat tcttctgttg attataaaac aaacttaccg
    75901 tattgtggga aaaatctcta ctaatgactc gattagcatg tataacagcc attaacatac
    75961 cgagcatagc ataaaagttt gaaatatgct taataccaag cgatgtccct tgagtcttta
    76021 gaataaagaa tgtaaccaat atcggcggta taaacgagat aagcaaaccg aga
//
LOCUS       DAVHSO010000003        69610 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.003, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000003 DAVHSO010000000
VERSION     DAVHSO010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 69610)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 69610)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..69610
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.003"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(32..1951)
                     /gene="tet(M)"
                     /locus_tag="VVR18_000195"
     CDS             complement(32..1951)
                     /gene="tet(M)"
                     /locus_tag="VVR18_000195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HEU6031798.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDYLLEKYMSGKSLEALELEQEESIRFQNCSLFPLYH
                     GSAKSNIGIDNLIEVITNKFYSSTHRGPSELCGNVFKIEYTKKRQRLAYIRLYSGVLH
                     LRDSVRVSEKEKIKVTEMYTSINGELCKIDRAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRKKIENPHPLLQTTVEPSKPEQREMLLDALLEISDSDPLLRYYVDSTTHEIILSFLG
                     KVQMEVISALLQEKYHVEIELKEPTVIYMERPLKNAEYTIHIEVPPNPFWASIGLSVS
                     PLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
     gene            complement(1967..2083)
                     /locus_tag="VVR18_000196"
     CDS             complement(1967..2083)
                     /locus_tag="VVR18_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance determinant leader
                     peptide"
                     /protein_id="HEU6031799.1"
                     /translation="MILKYPENICMLCMPMVMHKNPSDKSIYHWDFYALLGF"
     gene            complement(2328..3260)
                     /locus_tag="VVR18_000197"
     CDS             complement(2328..3260)
                     /locus_tag="VVR18_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6031800.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYKVNPHKKVVIALWVL
                     LGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKSI
                     DNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQL
                     ITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSIT
                     TNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVTV
                     SLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            complement(3257..4258)
                     /locus_tag="VVR18_000198"
     CDS             complement(3257..4258)
                     /locus_tag="VVR18_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HEU6031801.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            complement(4255..6432)
                     /locus_tag="VVR18_000199"
     CDS             complement(4255..6432)
                     /locus_tag="VVR18_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEU6031802.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYDPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            complement(6435..8882)
                     /locus_tag="VVR18_000200"
     CDS             complement(6435..8882)
                     /locus_tag="VVR18_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6031803.1"
                     /translation="MAYPIKYIENNLVWNKDGECYAYYELVPYNYSFLSPEQKIQVHD
                     SFRQLIAQNRDGKIHALQISTESSIRSAQERSKNEVTGKLKAVAYDKIDQQTDALISM
                     IGENQVNYRFFIGFKLLLNDQEFSMKSLTVEAKNALSDFVYDVNHKLMGDFVSMSNDE
                     ILRFQKMEKLLENKISRRFKIRRLDKDDFGYLIEHLYGQTGTAYEEYEYHLSKKKLDN
                     ETLIKYYDLIKPTRCLVEEKQRYLKIQQEDETVYVAYFTINSIVGELDFPSSEIFYYQ
                     QQQFTFPIDTSMNVEIVANRKALSTVRNKKKELKDLDNHAWQSDNETSSNVAEALESV
                     NELETNLDQSKESMYKLSYVVRVSANDLDELKRRCNEVKDFYDDLSVKLVRPFGDMLG
                     LHEEFLPASKRYMNDYIQYVTSDFLAGLGFGATQMLGENEGIYVGYSLDTGRNVYLKP
                     ALASQGVKGSVTNALASAFVGSLGGGKSFANNLIVYYAVLYGAQAVIVDPKAERGRWK
                     ETLPEISHEINIVTLTSDEKNKGLLDPYVIMKNPKDSESLAIDILTFLTGISSRDGER
                     FPILRKAIRAVTNSEVRGLMKVIEELRVENTPLSTSIADHIESFTDYDFAHLLFSNGY
                     VEQSISLEKQLNIIQVADLVLPDKETSFEEYTTMELLSVAMLIVISTFALDFIHTDRS
                     IFKIVDLDEAWSFLQVAQGKTLSMKLVRAGRAMNAGVYFVTQNTDDLLDEKLKNNLGL
                     KFAFRSTDLNEIKKTLAFFGVDPEDENNQKRLRDLENGQCLISDLYGRVGVIQFHPVF
                     EELLHAFDTRPPVRKEV"
     gene            complement(8866..9372)
                     /locus_tag="VVR18_000201"
     CDS             complement(8866..9372)
                     /locus_tag="VVR18_000201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016897981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6031804.1"
                     /translation="MGFLKSSIKSVGTLLLADFLFYGVAQSATPIFYERIDYMKKIRS
                     YTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAVMILGNLPPLSMIEGAFLKYF
                     GIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTYAGKKVTLGRNQPQEAITAVR
                     SEFYGISN"
     gene            complement(9347..9844)
                     /locus_tag="VVR18_000202"
     CDS             complement(9347..9844)
                     /locus_tag="VVR18_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HEU6031805.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            complement(9961..10182)
                     /locus_tag="VVR18_000203"
     CDS             complement(9961..10182)
                     /locus_tag="VVR18_000203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031806.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            complement(10225..11430)
                     /locus_tag="VVR18_000204"
     CDS             complement(10225..11430)
                     /locus_tag="VVR18_000204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HEU6031807.1"
                     /translation="MEGFLLNEQTWLQHLKEKRLAYGLSQNRLAVATGITRQYLSDIE
                     TGKVKPSEDLQQSLWEALERFNPDAPLEMLFDYVRIRFPTTDVQQVVENILQLKLSYF
                     LHEDYGFYSYSEHYALGDIFVLCSHELDKGVLVELKGRGCRQFESYLLAQQRSWYEFF
                     MDVLVAGGVMKRLDLAINDKTGILNIPVLTEKCQQEECISVFRSFKSYRSGELVRKEE
                     KECMGNTLYIGSLQSEVYFCIYEKDYEQYKKNDIPIEDAEVKNRFEIRLKNERAYYAV
                     RDLLVYDNPEHTAFKIINRYIRFVDKDDSKPRSDWKLNEEWAWFIGNNRERLKLTTKP
                     EPYSFQRTLNWLSHQVAPTLKVAIKLDEINQTQVVKDILDHAKLTDRHKQILKQQSVK
                     EQDVITTKK"
     gene            complement(11453..11605)
                     /locus_tag="VVR18_000205"
     CDS             complement(11453..11605)
                     /locus_tag="VVR18_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6031808.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            complement(11608..12993)
                     /locus_tag="VVR18_000206"
     CDS             complement(11608..12993)
                     /locus_tag="VVR18_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEU6031809.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            complement(13022..13408)
                     /locus_tag="VVR18_000207"
     CDS             complement(13022..13408)
                     /locus_tag="VVR18_000207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU6031810.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            complement(13424..13738)
                     /locus_tag="VVR18_000208"
     CDS             complement(13424..13738)
                     /locus_tag="VVR18_000208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU6031811.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            complement(14071..14628)
                     /locus_tag="VVR18_000209"
                     /pseudo
     CDS             complement(14071..14628)
                     /locus_tag="VVR18_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002844950.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
     gene            complement(14621..15322)
                     /locus_tag="VVR18_000210"
     CDS             complement(14621..15322)
                     /locus_tag="VVR18_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002844952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU6031812.1"
                     /translation="MTIKLDFRTKLFMTIVLSYVMVLGNIQVKYFLQALIISVIPIVL
                     LINTKHTRVAIIGMATLVFVYGADRFLMKLEYSPLVAILLILVMVVKKILPAFLMGKY
                     TILTSNVGESIYSLKKMKCPDEIAIPLTVMVRFFYAARIDYSQIKKAMRLRGLTLKKL
                     IKNPILLFEYRLVPLLMCLSKTADDLTVSAMTKGLAVNQKRTSISESRIGGIDCIFFV
                     IMVWAIYLYIRGKYA"
     gene            complement(15343..15930)
                     /locus_tag="VVR18_000211"
     CDS             complement(15343..15930)
                     /locus_tag="VVR18_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004804259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEU6031813.1"
                     /translation="MSKRLEVKDLINIGLFSVLGFVFMMIGSFLGMVPVLMPVVPFAQ
                     GVLVGPVNMLYSTKIKKRGMVFIQSLLIALVYVAMGHGPWALLTAVIAGIIAEVILKS
                     GEYTDVNKARLAFSVAPLCTLGNWLPIFISRNEYVKQMLERGYKQEFIDKMLSVMPNW
                     IIVVMAIGGIIGAYIGCSIGMAFLKKHFKKAGMEK"
     gene            complement(15942..16532)
                     /locus_tag="VVR18_000212"
     CDS             complement(15942..16532)
                     /locus_tag="VVR18_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004804257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEU6031814.1"
                     /translation="MKEEKQKVGQIRKKEIREAAKKCFLNKGFQLTTMEDVITEVGMS
                     RGGVYHHYGNTNEMFKDLMLDGNDYRNNLINEYLKNNRGKDKYQQMGDILVDKSLADT
                     ELMRLYTLLLQAKKYNQDLEKLYQELKLNTTNELSLIAKQLGIKADIFGDGFLVNYIN
                     AMILSSEVLCARNSFSQHKKYIKETMVNYIVDIDKR"
     gene            16872..17222
                     /gene="mobC"
                     /locus_tag="VVR18_000213"
     CDS             16872..17222
                     /gene="mobC"
                     /locus_tag="VVR18_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="HEU6031815.1"
                     /translation="MANRMRNERLEIKLTEEEKALFEEKRKLAKCKNMSHFIRKCVLE
                     KEIYQVDLEPFRDLQGLLSNATNNINQIAKRVNSTGIIYKDDINDMKKQIEHFSKELW
                     QIHSLLLNRTSGGD"
     gene            17228..18559
                     /locus_tag="VVR18_000214"
     CDS             17228..18559
                     /locus_tag="VVR18_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="HEU6031816.1"
                     /translation="MAITKIHPIKSTLNLAISYIVNGEKTDEQILVSTHKCHQETAHT
                     QFLRTRNDAGTNGTVLARHLIQSFLPGETSPEIAHQIGLELCKKILKDEYEFVLSTHI
                     DKGHIHNHIIFNNVNMVTGKCYQSNKKSYHQIRYQSDKLCKDNNLSVIDEFYESYKRK
                     YKTNGKSWYENEQAKRGSSWKSKLQFDIDRLIKQSKDWEEFLKKMAELGYEIKHGKHI
                     AFKPKDKQKFTRAKTIGEDYTEERLRERITENQSIKAPPVKKRIGNVINMNTNAKVKE
                     SKGYEYWATKHNLNTMAESVVFIREHGIKSVKQLDECIKKSAEERQNLQDKIKKIDKD
                     MQLLSDTMEQVHTVKKYRAYYKEYKANPSDKAFFEEHKSEITRYETDLAKLKKSYSKL
                     PDSKDILDKLDKLQEKKNTLMQEYSSTKSTMDELYQIRKNYGIYMGKEMER"
     gene            complement(18633..19292)
                     /locus_tag="VVR18_000215"
     CDS             complement(18633..19292)
                     /locus_tag="VVR18_000215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006627214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU6031817.1"
                     /translation="MDYKTMRNQIEDMVNDNHKDFVKAIISLEKGINNESALDKLYDA
                     YMDNDSLNLLHEEFDYMIEDLREQGQIKDLPYVQEEKDNLVNIVGNIVGEVDVVEREN
                     KNGEAFKVANFSVVSKDDEGNKVYHNCSAYGEKSDIPKDFKQGDFVKLFGQIRTSIDD
                     NGKEHSNIRILSSKLLKAKEQMKGQEEKKESVLGAIKKYQAEDKEKPKEKKEANKEAE
                     R"
     gene            complement(19335..28091)
                     /locus_tag="VVR18_000216"
     CDS             complement(19335..28091)
                     /locus_tag="VVR18_000216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEU6031818.1"
                     /translation="MRINDFHNILELIKQDVLQSEAEYLKLLKVVGNNQKYDFRSQLS
                     IYDKNPEATACAKFDYWREHFNRTVMRGQKGIPILEDYGTYKKVDYIFDISQTVSKNR
                     DVNEVNLWRFDKEAHRDVLKEMIKAEGYEESESTLENIFSLSRLYGDEKIDSLMNELR
                     ISDEDRISFTKFARDSVSYAVASRFKLDYPMDKELLKENFAMLDSISLMSLGETVSDI
                     SGTVIDATIQKSKELELQKEVLRGKEAGYNKIKEKLEEVEENVLRRDDQERISENERI
                     FRNGEYGRDNRENQREYTESVGGRDGLYEGISESDIRSDETGLSFKQRGAEQLRDVSG
                     SIQGEETDRASDGYAETSNRIYESREAETDGSLGDRGREPSAVQSDDFSPQRDDNQGN
                     SGNLKENTDKEIREADKASFSLPENRSGQIKLTIPLTQNDIDSILVNGGNHEGERLPI
                     IAEFSKGKTVEELGEYLKDTFRGGNGLFLNGAEVSSWYSDKGIHLAYGTSAREDMTQI
                     LSWSDAVRRINELLENGEFATNVELLEAHDYERDRVSESLWYLYHDLSEEGKAQGYFD
                     FMERGGEFPKETRQLSEALKNPDYLKNVISEYSRFLAGYKENRDVLRFHYHKVDSLYQ
                     KLQELELTRKEYTSNLIEPPKVQGFITEDEVLATISRGSGFDRGKERIIKFFKENHTL
                     QEKANFLKDEYGIGGGSHAVSGAKGSDEWHDAKGLKLQKNHCNDVFLTWSNVAKHIDE
                     LLSKNIYLEENKIESKTAIEEQKEPSYYSKGDPYNLMTDEMLEKVPELYAQEDVALAD
                     KQVHAAYIIPFRSNWTWYMTEYDRESKDAFGLVLGIEPEWGYFNLEELKELNAQRLIL
                     EDFPKTFRELRDSELKKQMDEQELHNVFNGELSFEENIADLEAPEEVEESIQAEPFQA
                     TLLDYLKEKEEVELNEKEDRSSDEFAVKEDDTVYFNHEEYKVREISKNPITGRNDLWL
                     DPARQGNHQIPIVAFTDNEDLLRQVSLERPDFIIGDEVKYKGKDYTITRFDDMGNNLK
                     TVTIKDNTEYLGGMITGSDVIPYRKESEIGKIFENLTYAKPEKTFEEAEIKKNQAHNF
                     KITEETLPSKLFPSERLNNNLEAISMLNRVESGERELDITAQEVLAKYVGWGGLADVF
                     DESKDGQWKEARAFLKENLSSSEYEAARESTLTSFYTPKTVIDGVYKTLSGMGFKQGN
                     ILEPSMGIGNFIGNLPDEMNQSKFYGVELDSVSGRIGKLLYPESDIQVKGLEETGFSN
                     NFFDVAIGNVPFGEYKVNDREYNRNNFLIHDYFFAKSIDKVRNGGVIAFITSSGTMDK
                     KDESVRRYLAARTEFIGAIRLPNDTFKGVAGTEVTSDIIFLKKRDSVLERDEDWIHLA
                     EDENGLSYNKYFVDHPEQVLGSMREVSGRFGKTLTCEPIAYLGTEINMASLKERIEIA
                     GERISKEAKYEEIELLDDEITSIPATDDVKNFSYTLIDDEVYYRENSLFIKKEVSDKN
                     KEKIKDYLELNAALKDVIYKQKEDFNEEEIKASQEKLNEVYDNFSKKHGFVNNLSNTR
                     ALKEDSNFPLVSSIEILDEEENFKAKGDIFSKRTITKAKIIDHVDTSLEALVLSVSEK
                     GYVDFDYMGSLTGKDRPTLIEELRGEIYLNIREEQNFYRPLSFNLEDGDLPFACANGS
                     NSYKYGYVTKDEYLSGNIRDKIVIVDSYLSKLRQTERELPHLGYEENGKEKELISYEM
                     NRLEYQKTELTKVLPKELEASEINVRLGATWIPIKDIEKFIFETLKTPGYAKWDIKVK
                     FSNLTSEWNVEGKSKDRGNDLAEMTFGTNRVNAYKLIEDALNLKETKVFDQIVNPDGS
                     KTSVLNKKETMLAGQKQELLKEEFKNWIFNDQERRNRLVKLYNERFNSIRNREYDGSN
                     LSFEGMNTEIDLRPHQRNAIARSLYGGNTLLAHVVGSGKTFEMVASAMESKRLGMCSK
                     SLFVVPNHLTGQIGREFMQLYPSANIMVADKKDFEPKNRKRFIGKIATGEYDAVVIGH
                     TQFEKIPMSKEYQEKHIQDQIDEIVNYVEEYKHDRNQNFTVKQLEKTKKKLETRLEKL
                     NDDFKKDDVITFEELGVDKLFVDEAHGFKNLYLYTKMRNVAGIGQSEAFKSSDMFMKC
                     RYMDEMTGGKGVVFATGTPVSNSMTELYTMQRYLQYESLKKNNLEHFDSWASTFGETQ
                     SSFELSPEGTGYRVKTRFSKFYNLPELMSMFKEVADIQTADMLNLPTPEANYEVIKTE
                     PSEEQKEILKSLSERADDVRNRVVEPDVDNMLKITNDGKKLALDQRLINPLLPDNPDS
                     KVNVCVKNVFAIWDKTKENRSTQLLFSDMSTPKGDGEFNIYDDIREKLVSMGIPKEEI
                     AFIHEANSDKQKDELFAKVRKGEVRILMGSTQKMGAGTNVQNKLIAMHDLDVPWRPAD
                     LEQRAGRIVRQGNENEKVNIYRYVTENTFDSYLWQTIENKQKFISQIMTSKTPVRVAE
                     DVDESSLNYAEIKALATGDPKIKEKMDLDNEVTKLKMLEANYKSNRYRLEDKVAKNYP
                     EEIARTEKLIEAVKKDIASVEPKAEGEEKFTSITIAGEKITDKKLAGERLLEAISKVK
                     INESKVIGRYRNMDLEVSYNFFTNEHNFSLNGAAKHSGELGTSVDGNITRLDNALEKM
                     PEKLNRLEEKLISTKEQLENAKEELKKPFEKADELKTKVLRLAELNKLLDMGEVEEKR
                     NDNPLVEDVKRAIIDFCNREYEENHSYDEFNTLYPDLKHIGIAYTNTPDERHGIQYEL
                     NLEEKTWTQYIDDTPIKTESFDYESKGENEALRNMKNEMEMSSFSDLVYVDSEDLKAA
                     TGLEIDDEGNFYDPLSKDLDNDGIPDRYDNDFKDSDYFESTYDVEDNLHSKEETAQKS
                     EDKPSILGQIRAYQNESKTEEKQKTKEQEFLR"
     gene            complement(28178..29605)
                     /locus_tag="VVR18_000217"
     CDS             complement(28178..29605)
                     /locus_tag="VVR18_000217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA binding domain-containing protein"
                     /protein_id="HEU6031819.1"
                     /translation="MTIDEIKKLIQNGEKIDVEFKESRNALTKDVFDTVCSFNNRNGG
                     HILLGVNDKRDIVGVSEDKVDKIIKEFTTSINNSQKMYPPLYLLPEVFELDSKKVIYI
                     RVPEGYQVCRHNGRIWDRSYEGDINITDHAELVYKLYARKQGSYFVNKVYPNLDIEFL
                     DTDVIDKAKRMAVARNKNHVWENMSYEELLRSANLILTDPETKHEGITLAAILLFGKD
                     NSIMSVLPQHKTDAIFRVENKDRYDDRDVVITNLIDSYDRLIAFGQKHLNDLFVLDGI
                     VNVNARDRILREIVSNTLAHRDYSSGFPAKMIIDDEKIMIENSNLAHGMGALDLQKFE
                     PFPKNPAISKVFREIGLADELGSGMRNTYKYTRLYSGVDPLFEEGDIFRTIIPLKKIA
                     TQKVGGSGVAQDVAHSVAQDVAHDKIALAEFIKEKIRGNNKITRKAIADEAGVSVKTI
                     ERTIKEMDNLQYVGSGSNGHWELNE"
     gene            complement(29625..29804)
                     /locus_tag="VVR18_000218"
     CDS             complement(29625..29804)
                     /locus_tag="VVR18_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbrB/MazE/SpoVT family DNA-binding
                     domain-containing protein"
                     /protein_id="HEU6031820.1"
                     /translation="MKDTFMDTAKVMSKGQVTIPKRIRELLDLQNGDYVTFVVNKDKV
                     QIQNSKTFIEENIDK"
     gene            complement(29888..31594)
                     /locus_tag="VVR18_000219"
     CDS             complement(29888..31594)
                     /locus_tag="VVR18_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000779853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase 3"
                     /protein_id="HEU6031821.1"
                     /translation="MNLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLI
                     KMANPESYDEKYAKWNMADLPIIPKEYKYEIAKSTKKQFTILKKLMNDKDIDIVINAC
                     DAGREGEAIFRLVYNQANCKKRMKRLWISSMEDSAIKEGFDNLKDGSSYDNLFESAQA
                     RAIADWLVGMNLSRLYSCLYKQNYSVGRVQTPTLAMIVKRDGEIANFKKEKYFTVELS
                     LNGFTLSTDRIDDEITAEQLLNLVGDKIEITDVIQKEKITKPELPFDLTTLQRECNKY
                     FGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMIVSTVNNILGKNDFDTERIKTVF
                     NSKKVTDHHAIIPTASSMNENLTSLPESELKVYELILNKLHASVGYPLIENTTKIVAE
                     FDGFEFTSSGKVIVDDGFTKYLNEYAKKKNEDTVLPDVKIGYSLDIKDKEIKEKYTQP
                     AKHFTEDLLLKAMELAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNL
                     IATHKGISLVTIVADTFKSAETTAKWEMELSDIAQGQSSEENFLEAIENEIKEVVSTY
                     TK"
     gene            complement(31692..33878)
                     /locus_tag="VVR18_000220"
     CDS             complement(31692..33878)
                     /locus_tag="VVR18_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4366 domain-containing protein"
                     /protein_id="HEU6031822.1"
                     /translation="MKTSLKNKRITAIVVAFTLLMVGVLGVLKVGAKTVFASNEPPEK
                     YETYYELKFEDHTSDDTFRGFYHLGKGNKEGQPLNFKFSLSKSFEEKGGVVVDKYNET
                     FTNENMDKVNQLDDLRYMTKKPYPYYRIHNIGTGAFTSIVSPRDKDNYYIGDITENAE
                     ERTVKGKKANVIVYTCPVLQLNRNIEKVTVDYEGEFKEETKNSIIGRVKEANPNINNV
                     KEIKIVKDKLIIETWNRFHTGVPYLELPLEDLYKRVANASAQTDNKDTKDEESQTKSE
                     VKIKYQYQDGNVYKEYSASFDKNQMIDASDLEMLPDNMSFNDDFVSYTVKGDGSDSII
                     RIVKKLESNAQTQTEKPKTEDKGIQTELSKDDISKMEKESKELQEKLDKLNQEIKDKD
                     KLSDKQKEKIKDLEEKIDKLKEKLEKGKDDKDLSADIKKEIEKLTEKIKELEKKTNEV
                     GKATVTHNPTVTPISPISGMKTGTGNFPQTSVSDTGKGSSSQDNTGKITKDTNIGKNN
                     DKEKEVRYPNKLTPKQPANNSSQDSSMDGSSKNVNTNKGVASAPSKARGTVTENKDNA
                     NKDYPIHHNDSKDNKETDMYSADARQFVTFTTKNGKTFHLIINHDEDSENVMLLTEVS
                     EDDLLNMVEKKEAPKQEITKEEPEKEEPKPVKKEESSNMGTYLILILVVAGALGAGYY
                     FKVVKKKEDKELEGFEEEDDDFFSEAEESENEVDETETEDKEDELE"
     gene            complement(33856..34092)
                     /locus_tag="VVR18_000221"
     CDS             complement(33856..34092)
                     /locus_tag="VVR18_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6031823.1"
                     /translation="MKKELTAVKNRIKKLKDKKALIDEELEPLFIREEELENEEIIAI
                     CRKNNITISDLMAKVNREKAEVKKEKTNENQFEK"
     gene            complement(34105..36237)
                     /locus_tag="VVR18_000222"
     CDS             complement(34105..36237)
                     /locus_tag="VVR18_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002843615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEU6031824.1"
                     /translation="MGKKLKKDFKERQRARIEKERLQSNSSIEPEENKLKHNDDYRGK
                     IVHDKDRFQDKVHEKVSKRSAETELNGKTSKRNARYRSPETGSVSQEEIGKADYDTEV
                     KDGKIYDPLGKDLDNDGIIDRYDNDFRDSDYFESTYDVEDNLQHKVEDTKGFSKSQKA
                     QKKNYKRKNYSDKLYTRKKDKEAKEEKADSKKSGKEAILDREKKNRLSKEQERAFKNK
                     TSKVSALSGLAKGSETVRDYLSHGSDENQGVEAGEKTADTSSKLIHGIKNYSDKKKAK
                     KGYDLTNKDYKIRKRKSKLEFRDAKEELKKTQEYQKANNFKRFQKRKQMKDSIKRKNK
                     SRLRDRIKEGLIGSLKSSKEVILRKAKGLMIIFIGLIILGTFFINFAGTGMTGFMNST
                     SSVLTTSYLSKPNVLSEINENFSEMEKELQSEVDNVEENYPGYDEYILNNTEYIGHNV
                     HELLSYITSRCGEVKNASEVSSVLNELFKSMYDLEYKEEVEIRYRTVTETYTDEDGNE
                     YTESHEEPYEYKKLIVTLHKKEMDSIIRKVFANYPDNLKHYEALFLAQGNMGEAFGNS
                     DLIASNGGIGGGKEYEASTEVQKKIVNAAYITPSPGAGWCAMWVSQVYQNAGLGYIGG
                     NACDMYRNYTFTSDKSKLKVGMLVAVESSSSGSTAGLTYGHVGIYIGDGKVIDNIGRI
                     RVTTLDDWIASFCQHHPVGFGFPPNVNR"
     gene            complement(36242..38671)
                     /locus_tag="VVR18_000223"
     CDS             complement(36242..38671)
                     /locus_tag="VVR18_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6031825.1"
                     /translation="MKDKRKIQQLKLEQNQKKLRSQKQDLKQNKGKSKKDRGGLLDLI
                     FRKEPKRYTVEDTIPYLRLLKSGICQIDEKHFNKSIAFEDINYQLALEEDRDLIFNQF
                     ANFLNSFDPSVSIEFSYINQLGRNEEMKSAIQIPDKKDGFDDIRLEFREMLKSQIVKG
                     NNGLKKSKYVTFTVEADNLEQATSKLERLEIDILSSLKSMGVRAESLNGEERLKILHD
                     VLNPNKTFEFSYKDLKKKESTKTYIAPDEFNFTPSRYFKFGKFIGAASHFQILASELS
                     DRMLAEFLDIDDNINISFHIKAIEQSEAIKMVKRKNTDIDKMKIEENKKAVRSGYDMD
                     ILPSDLITYGEDVKSLLKDLQTRDERMFVVTIIFMNFARTIQRLDNTISQISSIANKH
                     NCKLKRLDHSQEQGLISVLPLGVNKIEIDRGLTSSSTAVFMPFTTEELFINSANSLYY
                     GLNALSHNLIMADRKKLKNPNGLILGTPGSGKSFSAKREMANAILTTDDDVIICDPEG
                     EYGNLVRQFKGEVIKVSSKSKDYLNPLDINMNYGDGDAPLKDKANFIMSMLELVVGGS
                     GLTAEEKSVIDRCLPKIYEKYFENPKPCNMPILQNLYDMLKNQEEKVGKKLATEMEIY
                     VTGSLNVFNHQSNVDLNKQLLCFDIKELGSQLKKIGMLVIQDQVWNKVSQNRGNKATR
                     YYIDEFHLLLKDEQTASYSVEIWKRFRKWGGIPTGITQNVKDLLMSKEIENIFDNTDF
                     VLMLNQASGDREILARKLKISQPQLKYVTNSNAGEGLLFFGNTIVPFLDKFPKDTILY
                     QKMTTKPEEVR"
     gene            complement(38583..38972)
                     /locus_tag="VVR18_000224"
     CDS             complement(38583..38972)
                     /locus_tag="VVR18_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrgI family protein"
                     /protein_id="HEU6031826.1"
                     /translation="MAYVPIPKDLKKVKTKVAFNLTKRQLIGFTIAGLIGIPIYLFMR
                     KVVPNDIAVIFLIVSTLPIFFITLFEKDGLSFEKYFKYIYLHKFYQPQKRVRKEVYLE
                     RQKKNSAAKVRTKPKEVKKSKTGLKAK"
     gene            complement(38976..39239)
                     /locus_tag="VVR18_000225"
     CDS             complement(38976..39239)
                     /locus_tag="VVR18_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6031827.1"
                     /translation="MNKRKTVLIAVAVGTGILAVMDRIRLHIKENDLEERTKDIGRCH
                     NDFCLMQERYNRSTDEQIASIQEEIGSVYEHIEELSKGKEDGR"
     gene            complement(39257..40120)
                     /locus_tag="VVR18_000226"
     CDS             complement(39257..40120)
                     /locus_tag="VVR18_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031828.1"
                     /translation="MFGIFDKIEEFFKDLLLGGIQANLESMFLDINDKVGAIATDVGK
                     TPMGWNGQVFSFIKSINDSVIIPIAGLIITAVLCIELINMVMQKNNMHDTDTFEFFKY
                     IIKMWIAVWLVSHAFQFSMAVFDVAQHMVNKAAGVINTSAVISGDQIVTMVEGLKDKG
                     LGELVMILFETSLIKVAIQVISIVIMLVVYGRMFEIYVYSSVSAIPFATMGNKEWGQI
                     GTNYIKGLFAIGLQGLFLMVCLGIYAVLVKTIQITDIHTSTFTILGYAVLLGLMMLKS
                     GTLAKSVLNAH"
     gene            complement(40140..40355)
                     /locus_tag="VVR18_000227"
     CDS             complement(40140..40355)
                     /locus_tag="VVR18_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002838961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Maff2 family protein"
                     /protein_id="HEU6031829.1"
                     /translation="MEFFTQAVNVLKILVMAVGAGLGAWGVINLMEGYGNDNPGAKSQ
                     GIKQLMAGGGIVLIGLKLIPLLANVLK"
     gene            complement(40359..40670)
                     /locus_tag="VVR18_000228"
     CDS             complement(40359..40670)
                     /locus_tag="VVR18_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEU6031830.1"
                     /translation="MKQEMININANLLAEPTFSSFDKEGETVEVVNFTLVKKYGKGKE
                     YINCAAYGEKSETAKAFEKGDLIHIFGYFKKREKDGKTYKNFVVKSYNKIEKKEENEE
                     E"
     gene            complement(40836..42620)
                     /locus_tag="VVR18_000229"
     CDS             complement(40836..42620)
                     /locus_tag="VVR18_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretory system conjugative DNA
                     transfer family protein"
                     /protein_id="HEU6031831.1"
                     /translation="MIDKILKDIKGLFKVQDKSKFFKQNIPYLAFFYVGNIFSHHVRA
                     YTGGDVIDKIFQGILELNTMSFIPSIHPIDILMGVEVAVLIKFIVYTKGKNAKKFRQG
                     KEYGSARWGTRKDIEPYVDEKFQNNILLTQTERLTMNGRPANPKYARNKNVLVIGGSG
                     SGKTRFYVKPNLMQMHSSYCVTDPKGTIVIECGKMLEDNGYEIKILNTINFKKSMKYN
                     PFAYLRSEKDILKLVQTIIANTKGEGEKAGEDFWVKAEKLYYTALIGYIFYEAPREEK
                     NFATLLDMIDASEVREDDETYMNPIDRLFEALEKKEPTHFAVKQYKKYKLAAGKTAKS
                     ILISCGARLAPFDIQELRDLMKEDELELDTLGDRKTALFVIISDTDDTFNFVVSIMYS
                     QLFNLLCDKADDEYGGRLPVHVRCLLDEFANIGLIPKFEKLIATIRSREISASIILQA
                     QSQLKAIYKDNADTIVGNCDSTLFLGGKEKTTLKELSETLGKETIDLYNTSETRSNAN
                     SYGLNYQKTGKELMSQDEITVMDGSKCIFQLRGVRPFLSDKFDITKHKNYKLLEDFNK
                     KNAFDIEEYIKRKGKAKLNRETVITRVQ"
     gene            complement(42617..43102)
                     /locus_tag="VVR18_000230"
     CDS             complement(42617..43102)
                     /locus_tag="VVR18_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009346332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PcfB family protein"
                     /protein_id="HEU6031832.1"
                     /translation="MINEEIARKTLNMEVKAAKVTGKLILNLLKKLMKEAEKLGGLEK
                     LVNANGNEVKLKDMVKKGQLEEIPVEEAELKELKKELNRYGVKFSVMKDKESGKYSVF
                     FQAKDMKVMDKAFKHALSESEKKTERKESIHKNIEKFKEMAKNALSKDKVKNKQKEQS
                     L"
     gene            complement(43099..43950)
                     /locus_tag="VVR18_000231"
     CDS             complement(43099..43950)
                     /locus_tag="VVR18_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6031833.1"
                     /translation="MIKELEKVMIEDVEYSFNPEKEYIKDGHAYCKVCHERKDGKALE
                     FFGKQMIFKTACKCDRDREAKEKERQKQLEIERLKSICFTSIIQWSYTFENYQGKENQ
                     SLIIAKNFVKDYELMKKENIGLLFYGTVGSGKTYLACSIANALIEQYQISVKIRNFSQ
                     IINELQKGGFDIDKNAYIESLVNTSVLILDDLGIERDTSYAKEQVYNIVNNRYLKHKP
                     TIFTTNLSYSQIENCTESVEYQRIYSRIIEMCIPVMVLGENYRKVIQEEKLKRNKERL
                     LTGGERT"
     gene            complement(43947..44717)
                     /locus_tag="VVR18_000232"
     CDS             complement(43947..44717)
                     /locus_tag="VVR18_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="HEU6031834.1"
                     /translation="MDFDYFYNREAERFNFLKVPEILVDGEEFKGLSAEAIILYSMLL
                     KRTGMSFKNNWVDKEGRVFIYFTVEEIMRRRNISKPTAIKTLDELDSKKGIGLIERVR
                     LGLGKPNVIYVKDFMSIIAVKENDFQKSKNLTSEVRDFNLRSKENELQEVQNVDSNYI
                     ENNKSKYSKREYSFGKSGLGTFQNVFLKDEDIGELQIIMAGELDNYIERLSTYLQSTG
                     KTYKDHKATILSWFYKDQGSKKKTNIPTWEEYNKGVHL"
     gene            complement(44808..45089)
                     /locus_tag="VVR18_000233"
     CDS             complement(44808..45089)
                     /locus_tag="VVR18_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031835.1"
                     /translation="MRWIIKIILFPISLVLSILTAFLTFLLGIGTALLYLLMMFCIFG
                     AIASFLQKEVTIGIEALIIGFLVSPYGIPMVGATVIAFLQGINEAIKSI"
     gene            complement(45254..46612)
                     /gene="rlmD"
                     /locus_tag="VVR18_000234"
     CDS             complement(45254..46612)
                     /gene="rlmD"
                     /locus_tag="VVR18_000234"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEU6031836.1"
                     /translation="MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMR
                     VLKVNKKIGFGKVEKYLVQSPHRNQDLDLAYLRSGIADLGHLSYPEQLKFKTKQVKDS
                     LYKIAGIADVEVAETLGMEHPVKYRNKAQVPVRRVNGVLETGFFRKNSHNLMPLEDFF
                     IQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVRRGHYSGQIMVVLVTTRPK
                     VFRVDQLIEQVIKQFPEIVSVMQNINDQNTNAIFGKEWRTLYGQDYITDQMLGNDFQI
                     AGPAFYQVNTEMAEKLYQTAIDFAELKKDDVVIDAYSGIGTIGLSVAKHVKEVYGVEL
                     IPEAVENSKKNAQLNNISNAHYVCDTAENAMKNWLKDGIQPTVILVDPPRKGLTESFI
                     KASAQTGADRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVECIALIQR
                     VK"
     gene            complement(46686..47660)
                     /locus_tag="VVR18_000235"
     CDS             complement(46686..47660)
                     /locus_tag="VVR18_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HEU6031837.1"
                     /translation="MRKKLFLTSAAILWAVTAMNSVYAATDVQKVIDETYVQPEYVLG
                     SSLSEDQKNQTLKKLGYNASTDTKELKTMTPDVYSKIMNVANDSSLQLYSSAKIQKLG
                     DKSPLEVKIETPENITKVTQDMYRNAAVTLGVEHAKITVAAPIPVTGESALAGIYYSL
                     EANGAKVPQANKDLAQEELKTLSDINAENKDKSGYDANKLNVALADIKSGLAKAKESK
                     GNLTEEDIRKIVEDTLKNYKLDQVITGNQINIIINFALNLSKSDILSNADFTKTLNDL
                     KQSIVSQAGDSFKNINLNFDADKALEDGGNFLSSLWQALVNFFKSFGS"
     gene            complement(47734..48348)
                     /gene="pmp23"
                     /locus_tag="VVR18_000236"
     CDS             complement(47734..48348)
                     /gene="pmp23"
                     /locus_tag="VVR18_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000476388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase Pmp23"
                     /protein_id="HEU6031838.1"
                     /translation="MFKRIRRVLVLAVFLFAGYKAYRVHQDVKQVMTYQPMVREILSE
                     KDTPANEELVLAMIYTETKGKEGDVMQSSESASGSTNTINDNASSIRQGIQTLTGNLY
                     LAQKKGVDIWTAVQAYNFGPAYIDFIAQNGKENTLALAKQYSRETVAPLLGNTTGKTY
                     SYIHPISIFHGAELYVNGGNYYYSRQVRLNLYIIKCFTLFSTSG"
     gene            complement(48348..49322)
                     /locus_tag="VVR18_000237"
     CDS             complement(48348..49322)
                     /locus_tag="VVR18_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HEU6031839.1"
                     /translation="MDIYIKKAIIHQFSPDDTELFLADKFLNITPKIEEYLRKKIEHV
                     YSDEAKTGIFEEENPFFNHITDDLLETSVTLANLWKEEFSISENLKTNDLIFVQFSKE
                     GVEHFAFLRIALRETLTHLGGEVDNPIKLTQNNLPGFGTGADEALVVNLQSRKYHLIE
                     KRIKYNGTFLNYFSDNLLAVAPKISPKKSIKELEKTAQRIAESFNTDDFQFQSKVKSA
                     IFNNLEESNELSPEKLANDLFDNNLTARLSFIDQVKEAVPEPVQFDEIDASRQLKKFE
                     NQKLSLSNGIELIVPNNVYQDAESVEFIQNENGTYSILIKNIEDIQSK"
     gene            complement(49330..50586)
                     /locus_tag="VVR18_000238"
     CDS             complement(49330..50586)
                     /locus_tag="VVR18_000238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HEU6031840.1"
                     /translation="MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVM
                     AAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQAN
                     CAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPKTELLDFDAIL
                     KQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPV
                     PYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFK
                     EVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQ
                     NLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITAREFGEEESRKVAELIIKTLKN
                     SENEAVLEEVRSAVKELTDAFPLYEE"
     gene            complement(50648..51079)
                     /locus_tag="VVR18_000239"
     CDS             complement(50648..51079)
                     /locus_tag="VVR18_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014947335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6031841.1"
                     /translation="MLRDLQETDVKAICDINQEALGYTFSPEETASQLARLSQDSHHF
                     LLGYEDAANHVLLGYVHAEVYESLYSKAGFNILALAVSPQAQGQGIGKSLLQGLEEEA
                     KRCGYGFIRLNSANHRLGAHAFYEKVGYTCDKMQKRFIRIC"
     gene            complement(51081..51683)
                     /locus_tag="VVR18_000240"
     CDS             complement(51081..51683)
                     /locus_tag="VVR18_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HEU6031842.1"
                     /translation="MMDRIRQELEKGGAVVLPTETVYGLFSKALDEKAVDHVYQLKRR
                     PRDKALNLNIASFEDILHFSKNQPAYLQKLVETFLPGPLTIILEANDRVPYWVNSDLA
                     TIGFRMPSHPITLDLIRETGPLIGPSANISGQASGVTFEQILKDFDQEVLGLEDDAFL
                     TGQDSTIVDLSGDKVKILRQGAIKREDILARLPEISFEEA"
     gene            complement(51667..52506)
                     /gene="prmC"
                     /locus_tag="VVR18_000241"
     CDS             complement(51667..52506)
                     /gene="prmC"
                     /locus_tag="VVR18_000241"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HEU6031843.1"
                     /translation="MKLAQLFSNFEEELIRQGEEAESLSFVYRSLKNLSFTDFIFALQ
                     QEVTTEEEKQFVEDIYQQLAAHKPAQYIIGQADFYGMHLKVDERVLIPRPETEELVEL
                     ILTENLETNLSVLDIGTGSGAIALALAKNRPDWSVTAADISQEALDLARENAKNQNLQ
                     IFLKKSDCFTEISEKYDIIVSNPPYISREDESEVGLNVLYSEPHLALFADEDGLAIYR
                     RIAEDATDYLKDSGKIYLEIGYKQGQCVPELFRKHLPEKRVRTLKDQFGQNRMVVVDD
                     GQD"
     gene            complement(52506..53585)
                     /gene="prfA"
                     /locus_tag="VVR18_000242"
     CDS             complement(52506..53585)
                     /gene="prfA"
                     /locus_tag="VVR18_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HEU6031844.1"
                     /translation="MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSKEEASNR
                     DTVIAYREYKQVLQNIVDAEEMIKESGGDADLEEMAKQELKDAKAEKEEYEEKLKILL
                     LPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAEAQGWRFEVMEASMNGVGG
                     FKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDI
                     DPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNREKAMKIIR
                     ARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTIL
                     SGKLDEVVDALVLYDQTQKLEELNK"
     gene            complement(53595..54074)
                     /locus_tag="VVR18_000243"
     CDS             complement(53595..54074)
                     /locus_tag="VVR18_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6031845.1"
                     /translation="MTIELRDVTMENYFDVLNLDVKEYQKQFIATNAISLAEAYVYTK
                     NGDFVATLAVYDNDAIIGFVMIAYDKKIGISSGNYLLFRFMIDKNFQNQGYFKPIMDK
                     VLDYVRTAPAGLSNKLWLSYEPENEQARFCYLSYGFKETGEISENEVVAIYDLTIEK"
     gene            complement(54064..54663)
                     /locus_tag="VVR18_000244"
     CDS             complement(54064..54663)
                     /locus_tag="VVR18_000244"
                     /EC_number="2.7.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidine kinase"
                     /protein_id="HEU6031846.1"
                     /translation="MAQLYYRYGTMNSGKTIEILKVAYNYEEQGKGVVIMTSALDTRD
                     GVGYVSSRIGMKRPALAIEETTDIFGYIRDLPEKPYCVLVDEAQFLKRHHVYDLARVV
                     DELDIPVMAFGLKNDFRNELFEGSKYLLLLADKIDEIKTICQYCKKKATMVLRTQDGL
                     PVYDGEQIQIGGNETYISVCRKHYFTPMITSNKEQNYDN"
     gene            54786..54968
                     /locus_tag="VVR18_000245"
     CDS             54786..54968
                     /locus_tag="VVR18_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005589823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="HEU6031847.1"
                     /translation="MPFVRIDLFEGRTLEQKKALAKEVTEAVVRNTGAPQSAVHVIIN
                     DMPEGTYFPQGEMRTK"
     gene            55105..56478
                     /gene="mnmE"
                     /locus_tag="VVR18_000246"
     CDS             55105..56478
                     /gene="mnmE"
                     /locus_tag="VVR18_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002906470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HEU6031848.1"
                     /translation="MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFKGKDL
                     NKVASHTLNYGHIIDPLTGKVMDEVMVGAMKSPKTFTREDIIEINTHGGIAVTNEILQ
                     LAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNIAVKQLDGSLSD
                     LINNTRQEILNTLAQVEVNIDYPEYDDVEEATTAVVREKTMEFEQLLTNLLRTARRGK
                     ILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNINGVPLKLI
                     DTAGIRETDDIVEQIGVERSKKALKEADLVLLVLNASEPLTAQDRQLLEISQDTNRII
                     LLNKTDLPETIETSKLPEDVIRISVLKNQNIDKIEERINNLFFENAGLVEQDATYLSN
                     ARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLF
                     SQFCLGK"
     gene            complement(56525..57460)
                     /gene="dapA"
                     /locus_tag="VVR18_000247"
     CDS             complement(56525..57460)
                     /gene="dapA"
                     /locus_tag="VVR18_000247"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HEU6031849.1"
                     /translation="MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDG
                     ILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFG
                     GFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLAD
                     HPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGD
                     EMHEMFTAIAESDMKKAAAIQRKFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPL
                     VPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY"
     gene            complement(57516..58592)
                     /locus_tag="VVR18_000248"
     CDS             complement(57516..58592)
                     /locus_tag="VVR18_000248"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000542485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HEU6031850.1"
                     /translation="MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKS
                     LKFKDQDITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQNP
                     DVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGA
                     GMGAILETQRELREVLNDGVKPCDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYT
                     YEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAF
                     PGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNS
                     VQIAETLHERGLVRPTAELKFELK"
     gene            complement(58934..59006)
                     /locus_tag="VVR18_000249"
     tRNA            complement(58934..59006)
                     /locus_tag="VVR18_000249"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(58971..58973),aa:Thr,seq:ggt)
     gene            complement(59106..59615)
                     /locus_tag="VVR18_000250"
     CDS             complement(59106..59615)
                     /locus_tag="VVR18_000250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HEU6031851.1"
                     /translation="MKKLTIRDVADIAIVAAIYVVLTVTPPLNAISYGAYQFRISEMM
                     NFMAFYNPKYIIGVTIGCMIANFFSFGLLDVFVGGGSTLVFLSLGVWLFAKYSKDYLF
                     NGLIRKDHFFFSILFSISMFTIAAELNIVAELPFFLTWFTTGIGEFASLIIGAIIIGK
                     IGRRIDLSK"
     regulatory      complement(59613..59709)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
     gene            59738..60169
                     /locus_tag="VVR18_000251"
     CDS             59738..60169
                     /locus_tag="VVR18_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HEU6031852.1"
                     /translation="MKKPIQKFFNNEILAYLFFGLATTLVSILSRLVIYQLSHQELLA
                     TALANIIGILFAFITNDTIVFKQKKKNRLIRLVKFSLARLSTFLLDLFLTFLFVTQFP
                     HIIGQFVTENIDKINAIETIIAQIFIIIINYILSKAYIFRK"
     gene            60251..60628
                     /gene="mscL"
                     /locus_tag="VVR18_000252"
     CDS             60251..60628
                     /gene="mscL"
                     /locus_tag="VVR18_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="large conductance mechanosensitive channel
                     protein MscL"
                     /protein_id="HEU6031853.1"
                     /translation="MLKNLKSFLLRGNVIDLAVGVVIASAFGAIVTSLVNDIITPLIL
                     NPALKAAKVERIAQLSWHGVGYGNFLSAIINFIFVGTALFFIIKGIEKAQKLTGIKKE
                     KTAEKKPTELEVLQEIKALLEKK"
     gene            complement(60670..61764)
                     /gene="hemH"
                     /locus_tag="VVR18_000253"
     CDS             complement(60670..61764)
                     /gene="hemH"
                     /locus_tag="VVR18_000253"
                     /EC_number="4.98.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrochelatase"
                     /protein_id="HEU6031854.1"
                     /translation="MKKAILMMTFGSPEETTFEGVADFFTNIRRGVRPQDHEIQTLYD
                     NYVRIGGTPLQKITHQEVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCI
                     CLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
                     SFKIIFSAHSVPIFALDFGDPYIDQIFENSKLVVEKLGLSSEQYTNTWQSESDIGIPW
                     IKPDVLEYLREQTAHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMP
                     NTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVK
                     KLIEKKGRENVKMPYLIKKMLEKAGKLPKE"
     gene            61918..63141
                     /gene="pepT"
                     /locus_tag="VVR18_000254"
     CDS             61918..63141
                     /gene="pepT"
                     /locus_tag="VVR18_000254"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HEU6031855.1"
                     /translation="MTYPNLLDRFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPE
                     MKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDG
                     GVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTSLLGADDKSGIAEIMTAIEYLTAH
                     PEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAEL
                     HFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEEA
                     RASYIIRDFEKDAFEARKASMQSIADKMNEELGSDRVTLNLTDQYYNMKEVIEKDMTP
                     ITIAKAVMEDLGITPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTM
                     ERAVDTIIGIVAYKG"
     gene            complement(63177..63806)
                     /locus_tag="VVR18_000255"
     CDS             complement(63177..63806)
                     /locus_tag="VVR18_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031856.1"
                     /translation="MSKANQLLEQIHEEGIRQSLAEEVENLKAATNKADADLDEVNSQ
                     VKDVLTRIASALQQEKENAEQDPQTLVLYQKLYDILMSLHSYLESNNGSDADFDKVDA
                     LLDQLSAKSKDKTALLESTKAILVLNHQIQSKASASEETSPARNAEANGDNTSAENQP
                     NATAESNIETASDENKPSNTRDSKPAESTSENETTESSTTTGNQEKPVE"
     gene            63771..63992
                     /locus_tag="VVR18_000256"
     CDS             63771..63992
                     /locus_tag="VVR18_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031857.1"
                     /translation="MDLFQELICLAQKTFYFFLAICRRLLVAIYHVLLKQESYNPRLQ
                     GLTEIRNPDKTMFVQDAIRFAQQHGFNML"
     gene            complement(64263..65274)
                     /locus_tag="VVR18_000257"
                     /pseudo
     CDS             complement(64263..65274)
                     /locus_tag="VVR18_000257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669441.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
     gene            complement(65500..68619)
                     /gene="phtE"
                     /locus_tag="VVR18_000258"
     CDS             complement(65500..68619)
                     /gene="phtE"
                     /locus_tag="VVR18_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtE"
                     /protein_id="HEU6031858.1"
                     /translation="MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDG
                     SQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDALFSE
                     ELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQKQEH
                     VKDNEKVNSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLS
                     ASELAAAKAHLAGKNMQPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELY
                     DSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPI
                     SGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAY
                     IVRHGDHFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRII
                     AEDESGFVMSHGDHNHYFFKKDLTEEQIKAAQKHLEEVKTSHNGLDSLSSHEQDYPSN
                     AKEMKDLDKKIEEKIAGIMKQYGVKRESIVVNKEKNAIIYPHGDHHHADPIDEHKPVG
                     IGHSHSNYELFKPEEGVAKKEGNKVYTGEELTNVVNLLKNSTFNNQNFTLANGQKRVS
                     FSFPPELEKKLGINMLVKLITPDGKVLEKVSGKVFGEGVGNIANFELDQPYLPGQTFK
                     YTIASKDYPEVSYDGTFTVPTSLAYKMASQTIFYPFHAGDTYLRVNPQFAVPKGTDAL
                     VRVFDEFHGNAYLENNYKVGEIKLPIPKLNQGTTRTAGNKIPVTFMANAYLDNQSTYI
                     VEVPILEKENQTDKPSILPQFKRNKAQENSKLDEKVEEPKTSEKVEKEKLSETGNSTS
                     NSTLEEVPTVDPVQEKVAKFAESYGMKLENVLFNMDGTIELYLPSGEVIKKNMADFTG
                     EAPQGNGENKPSENGKVSTGTVENQPTENKPADSLPEAPNEKPVKPENSTDNGMLNPE
                     GNVGSDPMLDPALEEAPAVDPVQEKLEKFTASYGLGLDSVIFNMDGTIELRLPSGEVI
                     KKNLSDLIA"
     gene            complement(68829..>69610)
                     /gene="phtD"
                     /locus_tag="VVR18_000259"
     CDS             complement(68829..>69610)
                     /gene="phtD"
                     /locus_tag="VVR18_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtD"
                     /protein_id="HEU6031859.1"
                     /translation="HQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNLQYTVEVKNGS
                     LIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERPHSDNGFGNAS
                     DHVQRNKNGQADTNQTEKPNEEKPQTEKPEEDKEHDEVSEPTHPESDEKENHAGLNPS
                     ADNLYKPSTDTEDTEEEAEDTTDEAEIPQVEHSVINAKIAEAEALLEKVTDSSIRQNA
                     VETLTGLKSSLLLGTKDNNTISAEVDSLLALLKKSQPAPIQ"
BASE COUNT        19394 a        14680 c        11567 g        23969 t
ORIGIN      
        1 aaaccatatt tatataacaa cataaaatac actaagttat tttattgaac atatatcgta
       61 ctttatctat ccgactattt ggacgacggg gctggcaaac aggttcaccg gtagtaacat
      121 ggtacccttt taactctgtt aaacaaacac tacgtccatt tgtaaagaaa gttaaatcac
      181 tacgatattc ttgaatacac cgagcaggga tttctccact aagaatgacc tcattatttt
      241 tcaattgagt gtctacgatg ttcgcacaat atttaggagc atcgttgtat gctcgtgaaa
      301 gatattcctg tggcgcataa attttaaaac taagatatgg ctctaacaat tctgttccag
      361 ctttttttaa gacttgttcc aatacaatag gagcaagcat ccgaaaatct gctggggtac
      421 taacagggct atagtataag ccatacttaa aacagatttt acagtccgtc acattccaac
      481 catacaatcc ttgttcacag ccatagcgta tcccctccat aactgcattt tgaaacgatt
      541 gatttaagta tccaagagaa accgagctct catactgcat tccacttccc aacggaagcg
      601 gtgatacaga taaaccaatg gaagcccaga aaggatttgg cggcacttcg atgtgaatgg
      661 tatattctgc attttttaac ggtctctcca tataaatgac tgtaggctct tttagttcta
      721 tctccacatg atacttttct tgcaacagtg cactaatcac ttccatttgt actttcccta
      781 agaaagaaag tataatttca tgtgtcgtag aatccacgta atatcgtaga agcggatcac
      841 tatctgagat ttccaaaagg gcatcaagca acatttctct ctgttcaggt ttactcggtt
      901 caacagttgt ttgtagtaga gggtgcggat tttcaatctt ttttctctgt ggcaatagtt
      961 ttgtatctcc aagaacacta tttaacttca aaaactcatt ttgcaaaata acaatttctc
     1021 cagaataagc tctatcaatc ttacataatt caccatttat tgaagtatac atttctgtaa
     1081 cttttatttt ttctttttct gatactctaa ccgaatctcg taaatgtagt actccactat
     1141 aaaggcgtat atatgcaaga cgttgtcttt tttttgtata ttcaattttg aaaacatttc
     1201 cgcaaagttc agacggacct cgatgtgttg atgaataaaa tttattagta ataacttcta
     1261 taaggttatc aatccctata ttactttttg cacttccatg ataaagaggg aacagagaac
     1321 aattctgaaa tcttatgctt tcctcttgtt cgagttccaa tgcttctaat gatttaccgg
     1381 acatatattt ctctaaaagg taatcgtttc cctctattac cgtatcccat tgttcagatt
     1441 cggtaaagtt cgtcacacac atattaggat acagttctac cttctgtttg attacaattt
     1501 cggcagaaag tttctcttta atatcctgat aaaccgttga taaatcaatt ccattttggt
     1561 caatcttatt gataaaaaag attgtgggaa tccccatttt cctaagtgca tgaaataata
     1621 tacgagtttg tgcttgtacg ccatcttttg cagaaatcag tagaattgcc ccatctaaaa
     1681 ctgataatga acgatatact tctgctaaga aatccatatg tcctggcgtg tctatgatgt
     1741 tcaccttcgt attttcccac tgaaaagagg ttattcctgt ctgaattgta attcctctct
     1801 gacgttctaa aagcgtatta tccgtcctcg ttgtaccttt gtccacgctt cctaattctg
     1861 taatcgctcc actgttatat aataagcttt ctgttaaggt agtttttcct gcatcaacat
     1921 gagctaaaac tccaatatta ataattttca tgtgattttc ctccattcaa aaacccaaaa
     1981 gggcataaaa atcccagtga taaatacttt tatcactggg atttttatgc ataaccatag
     2041 gcatacaaag catacagata ttctccggat actttagaat cacatgataa aggtattctt
     2101 aaactgggta caaaaaacta agccctccta aaaaaggaca tccaattatt tgttcccact
     2161 atcaaattga cagtttattt aagaatacct tgccgcatat ttattaactc cttttaaata
     2221 gatacttaaa taatagcacg taagagcata tttgtaaagg aatctccaat tttttatcaa
     2281 agagagtacg tgattacaaa atagctgtaa taatgtacca atatttgtta ttctataatc
     2341 ttccaattac tcccgttctt ttcaagtacc aaatcaaatt gagatacctg cgttgctttg
     2401 gtctgctggt cgatatactc cactgtcagc gataccgtga cttgattatc cttacgattg
     2461 tgaataggat ttaccagttc ttgaaagatg tactcttttc cgattggttt taatatcccg
     2521 tcattcacat agtaggaaag ttcactggct gtcgctgtag gatagagctt gaagaacgtc
     2581 gttaaaaact cattgatttc attggttgta atggaatcaa ccgtcccctc actttcaatg
     2641 gcttttggtt tataacttga tttcttaggt atgttggtaa tggtcggatt cttaaccagt
     2701 accatatttc cagaaccatc tacatagaca ctcactatat aagcagagtg gacggtcttt
     2761 gtattttctc cctctgtaat gagctggtct acactgtagg ttacattaaa ctcattgtcg
     2821 ccagttggct ctaccgtcca tatctgaaat cctcttacag aagacgatac aggaatatct
     2881 ttgcgtactg tatcaacatt gagagcttga agttcatctg tcagatagcc ttttagactt
     2941 tccattcgat tatcaatgga cttatcggat tgctcccatg aatagtagac tttcgcaaag
     3001 ttctctacaa aattttctac atgatgagta tcaacgtatt ccttttctat gatagttgtt
     3061 tcgtgaatag tatgagtatc tatagctgta aagtgcttga atatcgcaaa gctgaaacta
     3121 agccctaaaa gtacccacaa ggcaatcaca acctttttat gaggattgac cttatagaca
     3181 cgaggtttct tttcctttgg tatctgtttt tctttattct gattttttct aaatttcatc
     3241 attaaatctt cctttctcat tgtttgattc gtcctgctcc cactaaatgc tgttgccagt
     3301 aggggcttgt taagtcggca taaccgattg ggtcgcctgc atgaaacata cggttattgc
     3361 caaggtatat cccaacatga gtaatataag agccagcgtt ataggtagaa tgaaagaaaa
     3421 ccaaatcgcc agcttgtgct tccgatagtg ggatatgctg ggtcacatca tattgctgtt
     3481 gtgcggttcg tggtaagtta attccagctt ttccatacgt ccattgtgtc agtccgctac
     3541 aatcaaaaga agtagtcggg gaagctccac cgtaaacgta tcgccagccc tcatatttca
     3601 gtgcttcgtc catgatggct tgtaccgtat catcatcaaa ctctgttgtg acaagatact
     3661 gcgttaccag ttgcacataa aacatattgc catagttgta tcgccagccc ccattgatag
     3721 gtatggctat gggattgggg taagacactt tttcgccacc tgaatactct tttgagaaac
     3781 tttgagccag ttcaaaggta tatttatttc cacgattagc cacataccct aagaaaccac
     3841 caccataatt gtaggactgg ataaccgatt ctaaatctac actgagcctt tcgctactgg
     3901 ctaataattc actgaaatac ttcacacctt gcttaatgga ttcttctgta ctcaatgaat
     3961 taggtggaag accgagggat tccgaggact gcataacatc ttccgcagta ccgcccgatt
     4021 ccacctgtat aatcgcaaga agtatgttga catattcttc aacgccatat tctttggcat
     4081 atttttctac cataggctta tgagccagca cttctgcgga aacattcaca cctccataat
     4141 gaatattgga aattccgctg tcctgttcat ctgaaaataa aatggcaaca aacagaagca
     4201 gtgagaagac catcaagaat aatccagaac caccaatcac taaagttttc aacttcatgg
     4261 tttcttaccg actttcttaa tggtggcggt tttgattggt ggtctacttc ttgtattttg
     4321 tagtggtact ctttgaacag tagacggacg ttcttttgtg attggacgtt gtgaagttct
     4381 atctgctgta gtggttgaag ttgctggctt ttgaacggtt ttttcttgaa cggtattgcc
     4441 ttggcgttcc acttttggac ttgaaaaatc ggacttaact gctggacgct cttgtttggc
     4501 ttgttgagat tccttatatg aagtctgaat attagactgt tttgaggtct gttcatcatg
     4561 atattgttct tgtcttgtag tcggtctttc atgaacagaa gaagcaggct gttttttctg
     4621 tttgacctgt tccatttcag agcgacgctt cgcaatggtt tttcgccttt gttcctgctg
     4681 ttccttgcgt ccactggctc tgtccgcttt ggtttgagaa atactactgg ttaaatcacg
     4741 gacattctct tttactttgg attttccttg atatactgca tatcttgcat tggtcggcaa
     4801 atctttaacc tgttctttca aaccactagc agtgtctacc attctgtctt tggtatcagc
     4861 tactgtaccg atggtttgac cgatacgttt tccaagtgtt gatttttcct ttccgtctgg
     4921 tcgggagtga tctgcttgtg tccttgcaga actccccgaa cccgactgtc cttttttacc
     4981 tgtaacaatg gcagacccag cccctagagt agtcatggaa cgtccaagtt tccgctgtag
     5041 acggtgcatg tgagcgtgca taagcatacg aggttttctc atcacacgac ttcccacact
     5101 ttgagaatcg ttactctgta gagaaaacat actcattaaa tcgcccagct tgaagtagat
     5161 tcctgcaaag gtcacaatct gtagaaaagc aatcaaaaag aacggataac cagccgataa
     5221 ggtatagagc atggttgaaa tactaaatgc tgtcgtaata atcaatgtga ttccagctcg
     5281 tgtcaaaatg gtattaaaga gctttgttat ggctcgtttt gacataccat caaatgatgg
     5341 aatcatgctt aaaataaagc tcacaggcag aaacatagca tagatgataa aaagtacctg
     5401 cgagaaaatc atgattcctg ttaataggaa tacaaatatg gaaatcccaa tattgaagac
     5461 aaataggaag aagactgtac ctaaacggtt aatggtcttt gtaatggtta gattggtatt
     5521 gcttctgtct tcaatttctt ccgcaacaat tttttctcta tcttcgccat tgttggaatc
     5581 tgggctggtg gagagcaggc tttccacacg gtcaataccg atactttcaa tgtctgaact
     5641 gttgtattga agcagtagcc acggttgctg aacctgtatg gaaaacaggc tatctctgat
     5701 taagtccacg ctgtccttgc cttgactatc ggaatggggc atgacaatct tcgtgccaag
     5761 tgataaactg gcattactga tgtctgatga aaagtcattg atttttttaa tgtagtcggg
     5821 atcgtaggca ataaaggaag ccgataggat aaacaccagc acaaaattca taatggcatg
     5881 aattgccttt gtggtttctc tctttatcag tcccgtatag gcaacataaa ccccaagaac
     5941 caaaatcaag agtaagagga atccaacata gaaaccctct gttgaaaatc cgtttgcact
     6001 cacaccagct aaggtctgca tattcttacc aatggaatct gctgtagcgg aaatgaagtc
     6061 taaggaatag gcttcctgta ctaagtaacc tgtcgcattg gaaacataca aactgattgt
     6121 ccaaataaaa ttggtaatgg catatagtcc atacatgacc tgttttccaa tcccgtccga
     6181 ccagttccac ggaagccagc cccagctatt atccacataa aaatccagtt gatagttttc
     6241 aagtgggtat cggctgtatt catttgccac attgaccgta tcatctacca agcccgcagc
     6301 ttgaaccacc gttcccagca tggctaaaag aaaaatggca atcacaagtg tgaaagccac
     6361 tgtcattgcc actttaccta gacgtttcag cgtccagttt gattttattc tgtttactat
     6421 tgatggtttc acatttacac ctcttttcgc acaggtggtc tggtatcaaa ggcatggagc
     6481 agttcttcaa atacagggtg gaactgtatc acaccgacac gaccatataa atcactgata
     6541 aggcattgcc cgttttccaa atcacgcaat cgcttctgat tgttttcgtc ctctgggtct
     6601 acaccaaaaa aggctaaggt ctttttaatc tcgttaaggt cagtggaacg aaatgcaaat
     6661 tttaagccga ggttattttt cagtttttca tctaagaggt cgtctgtatt ttgggtcacg
     6721 aaatataccc cagcgttcat agcacgacca gcccgaacca gcttcataga tagtgttttt
     6781 ccttgtgcta cctgtaaaaa gctccatgct tcgtctaaat ctacaatctt gaaaatgctt
     6841 cggtctgtat ggataaagtc taaagcaaag gtactaatga caatcagcat agcaacggat
     6901 aaaagctcca tagtggtata ttcctcaaag gaagtttcct tgtcgggaag taccaagtcc
     6961 gcaacctgta taatgttcag ttgtttttct aagctgatag actgctccac ataaccatta
     7021 ctgaataata aatgtgcaaa gtcatagtct gtaaaacttt cgatatggtc ggctatactg
     7081 gtacttagtg gcgtattctc aacccgtaat tcctcaatca ctttcatcaa ccctcgtact
     7141 tcactattgg ttactgcacg aatggctttt ctaaggattg ggaagcgttc cccatcacga
     7201 gaggaaatcc ccgtaaggaa tgtcagaata tcaatagcca gtgattcaga atctttggga
     7261 tttttcataa tcacataagg gtcaagtaag cctttgtttt tctcatcaga agtcagagtg
     7321 acgatattga tttcatggga aatctctggc aaggtttctt tccatctgcc acgttctgct
     7381 tttgggtcta caatcactgc ttgtgcccca taaagcaccg cataatagac gataaggtta
     7441 ttcgcaaagg atttaccacc acccagcgaa ccaacaaaag ccgacgctaa cgcattggtt
     7501 actgaaccct taaccccttg actggcaaga gcaggtttca gatagacatt gcgtccagta
     7561 tctaagctgt agccaacata aatcccctca ttttccccca gcatttgagt agcaccaaaa
     7621 cctaaaccag cgaggaaatc agaggtcacg tattgaatat aatcattcat ataacgcttg
     7681 ctggcaggta aaaattcttc atgtaagccg agcatatccc caaatggtcg taccagtttt
     7741 acgcttaaat cgtcataaaa atctttcact tcattacaac gacgtttgag ttcgtcaaga
     7801 tcatttgctg atacccttac cacataagac agcttgtaca tagattcctt gctttggtct
     7861 aaattggttt ccagctcatt cacactttcc agagcttccg ccacattgga gctggtttca
     7921 ttatcacttt gccaagcgtg gttatccaag tctttcagtt ctttcttttt attgcggaca
     7981 gtagataggg ctttacgatt cgctacaatt tccacattca ttgacgtatc aatcgggaat
     8041 gtaaattgct gttgctggta gtagaagatt tcagaggacg ggaagtccag ttctccgaca
     8101 atgctgttaa tggtaaagta agctacatag acggtttcat cttcctgctg gattttcaaa
     8161 tatcgctgtt tttcttccac caaacagcga gtaggcttaa tcaagtcata gtatttaatc
     8221 agcgtttcat tatccagctt tttctttgat agatggtact catactcttc ataggcagtg
     8281 cctgtctgtc cgtaaaggtg ttcaatcaga tagccgaagt cgtccttatc taacctgcgg
     8341 attttgaaac gacgagagat tttattttct aagagctttt ccatcttctg aaaacgcagg
     8401 atttcatcat tactcatact aacaaaatcg cccatcagct tatggttcac atcatagaca
     8461 aaatcagaca aagcattttt tgcttcaacg gtaagacttt tcatagaaaa ctcctgatcg
     8521 ttgagaagca acttaaagcc gataaagaaa cggtagttca cttgattttc gccaatcatg
     8581 gatattaaag cgtctgtctg ttggtcgatt ttgtcatagg caaccgcttt gagcttgcca
     8641 gtgacttcat ttttggaacg ctcttgtgca gaacgtatgc tggattctgt actgatttgt
     8701 aaagcatgaa ttttgccatc acgattttgt gcgataagct gtctgaaaga atcatgcact
     8761 tgtattttct gttctggact tagaaatgag taattgtaag gaacaagctc atagtaagca
     8821 taacattccc cgtctttatt ccagacgaga ttgttttcaa tgtatttaat tggatatgcc
     8881 ataaaattca ctcctaactg ctgtaatggc ttcttgtggc tggtttctgc caagcgttac
     8941 tttttttcct gcataggtca gctttggtcg cagtgcataa gcaatgacag acttcaaaaa
     9001 tccataaggc tttttaccat caaaagtttt tgtagacata aaccatgtga aagccacagg
     9061 aatcccaaag tatttgagaa atgctccctc tatcatggaa agagggggca agttgccaag
     9121 tatcatcact gcaaagagtg acacgacaaa ccatgtcatt tgcgtaaagg ttatgggaaa
     9181 cggaagtcta aaatcattga tagaatacag taccttttcc acagaccaga tactggtata
     9241 gcttcgtatt ttcttcatgt aatcaatcct ttcataaaaa ataggggtag ctgattgagc
     9301 caccccgtaa aatagaaaat ctgccagtag taatgtaccg acagatttaa tagacgattt
     9361 caaaaatccc atgattggtt gagataaacg ttcctgaaag gtctaaatcc cgaccatagg
     9421 cttgataatc aatatagttt tgaagactag ctggtacttc gcctaaagca cccgtttctt
     9481 caatgtagta gcgtgccacg tcatacatat catcacaatc ggaatgaatg ataatatcct
     9541 cttgatgttc gcttagttct tcaatgcttg aaaaatgagt gagcagagca gatagctccg
     9601 attgtaattc ttcgggtaat tccgatacca tttcccatag tcgattgagt tcgccaatgg
     9661 aagtgtattc gtcaaccgta aagggtaact cgtagtcatg aatggcgtat tcctcatatt
     9721 catcattcaa gccgattttc tctttgactt cctcaaagtc aatgggaaag gtaaaccacg
     9781 caccgaccaa ttcgccctca ttgtatttgc ctaaattcgc aatatagact tgcatatcgt
     9841 ccatatattc acgtcctttc tttgtagaga ttcaaaaatc cctaccgcac ttcgtttggt
     9901 gtaccattcc tttgcggaac ataagaaaac cacttatatt ccacaaaaga acggttttat
     9961 ttaagcacca ataatgcgat tgaatagctc tagtaaaatg tcttttactc cagcagcgtt
    10021 gaagactaag ccaaccgcaa taatcgcaat aattaaaaag ccaatcagtt tgctaaactc
    10081 acgcttgaag ccaagataca agccaatcac aacgattgct aaaagcacca gtgattgagc
    10141 gtttgataga aaccagttat aaaggttttg tccaaaattc ataaaaatgt tctcctctct
    10201 atattcaatg aatttgtatt tgagttattt ttttgttgtt atcacgtcct gttcttttac
    10261 tgactgttgc ttcaaaatct gcttgtgtcg gtctgtcagt ttcgcatggt cgagaatgtc
    10321 ttttacaacc tgcgtctggt tgatttcatc aagtttaatc gcaaccttta aggtcggggc
    10381 aacttgatga gatagccagt tcagcgtcct ttggaaggag taaggctctg gttttgtggt
    10441 tagttttaat cgttcacgat tgttcccaat aaaccaagcc cattcttcat tcagtttcca
    10501 atcagaacga ggtttggaat cgtctttatc tacaaaacgg atataccgat tgataatttt
    10561 aaaggcggta tgctctggat tgtcatagac gagtaaatca cggactgcat aataggcacg
    10621 ctcatttttc aatcgaatct caaaacggtt ttttacttct gcgtcttcaa tgggaatatc
    10681 atttttcttg tactgctcgt agtccttttc atagatacag aaataaactt cactttgtaa
    10741 tgaaccgata tagagggtgt ttcccataca ttccttttcc tctttgcgta ccagttcgcc
    10801 actgcgatag cttttaaaac tgcggaagac ggagatacat tcttcctgtt ggcacttttc
    10861 agtgagtaca gggatattta aaatccctgt cttatcgtta atggcaaggt caaggcgttt
    10921 catcacaccg ccagccacca aaacgtccat aaagaactca taccagcttc tttgttgtgc
    10981 cagaagatag ctttcaaatt gtctgcaccc acgacctttc aattccacca gaactccttt
    11041 gtccagttca tgggagcaaa ggacgaatat gtcgcctaaa gcataatgct ctgaataaga
    11101 atagaaacca tagtcctcat gaagaaaata ggacagtttc agttgtaaga tgttttcgac
    11161 cacctgctgt acgtctgttg tcggaaagcg aattcttaca taatcaaaca gcatttcaag
    11221 gggagcgtcg ggattgaagc gttccagagc ttcccaaagg gactgctgta aatcctctga
    11281 tggcttgact tttcctgttt caatatcgct tagatactgc cttgtaatac cagtcgcaac
    11341 agctaaacgg ttttgagata gtccataagc caagcgtttt tcttttaaat gctgtaacca
    11401 agtttgttca ttcagtaaaa atccctccaa tcaaaaaggc gtatgtcaac ttttaaagcc
    11461 catttgacat acgctgaaat tttgtaaatc ccttgtaacc aaaggatttt ctaatgtttt
    11521 tttgactgtt tcctgtcgat ttgtaccccc ctgttagata cggggggtta agtgctggcg
    11581 tggctattgc cacaccagcc agcaagatca gtccacacct gcgacttccg cttcgcacgt
    11641 cgcctgcgtg gactgtctgc tgttggataa ctttttaatt tcctccaaga aatcatatcc
    11701 ttttggtaca aggggagtat aaaactctga tatgacactt gttcctacat caacatagcc
    11761 acgacctttg attcgcttta agaagaaatc cttttgtacg tcactgccaa acatcatgcc
    11821 atagcccatt tcagacatac gacctaaagc cactctgaaa ttaaactgat cacggattcc
    11881 gtcgcctaaa tattttgcgt ctggacgttg acaagccagt attagaaaga agccagcttg
    11941 acgacctaac atgacaatct gtttcagctt attcataact gcggtgtttt cttttgttcc
    12001 cagcatttcc atgaaagcga cgtattcatc aaagattaag aagtgtgccg ggagacctaa
    12061 gtaagcataa tttttgccag tcttatagtt cttcatctgc ttcatttcct cactacgttt
    12121 catcatttct tcatagaatg tttcaatgca agaaagcaag tcttcttttc tatagtagac
    12181 atttgccatc acagaaccta agtccgcaag atcagcattt ttcgggtcaa gaatatacag
    12241 ttttgaatct gtatgaagca aggcttcaat cagtgtcagt ataaagtaag ttttaccgcc
    12301 acctgtacca ccagcaatca acatatgagg gagcttatca tattcccacc atacgttttt
    12361 cattaagcga agtttaccat ctttagcttc tacttcatca atagaaatac gactggctat
    12421 ggtgtcatag agcaaagtat attccacata ggaatccttt aactctttat ccgtcagctc
    12481 acagtacaag ccactctcta atttcttttc caagtgtaag agttggtctt gatattttcc
    12541 cagcgtgatt tccacccgta tctgtatcaa gccattttta agtcgataat acattttagg
    12601 gaagtaggtt atcttttcct ttgtacgacc agcactatct ttaaagaaac cctctgtttt
    12661 gacctgttca gattcatacc acttgttttc aagtatcatc tttgccagtt tttgacggtg
    12721 gtaaagttgt ttaaccgtat catagcgaac ccgtttgaat acaaacgcta ccagcaagca
    12781 gataagaatt gcgacactga aactgataat taaataggga atgtcaatct tatctgcttg
    12841 tgataggtta aaatcctgcc agttgatctg ctggattgtc ttcacatgaa acagtccgac
    12901 aaccagcagg aaaacaggca ggagtgacgc tatcgtaaaa tgaaagacta aatctttacc
    12961 agatgggcga atccttttac cacgctgttt catgcgaaaa agtctccttt ctacctagcg
    13021 actatttgtc ttgtgtcggt tctttctttg cttgtggttg agctttgaat gaactagaat
    13081 cctttgtcag cacaatatcg tctgccttga tataccagtc aacatctgct ccttgatagg
    13141 tggcagtagc aacggtgtcc gcaatgggat tgataagttc cacccgtgcg ttataatcaa
    13201 actctttcaa aggcacgctg gcaggaatac ttacttgaat catgcgtcct tgtcctttgg
    13261 attttaagtc ataggtacgt tccttgattt catctgaaac cgacccgtct tcattttgga
    13321 ttctcacttc acgacgtaga gcagagaatt tcaattctcc aaaagtcgtg tctttatcta
    13381 atacaatgcc atttgctaat ctcatcattt ttcctctctt tctttattct tttatcatgt
    13441 cgtcagcatg taaaaggtaa tttgtaaaac cacgagtgcc gattttgtag ccctctgcgg
    13501 taatacgtgg attgactaac ttcacacgtt cctcaaagcc gaaatgtttt tcgccagctt
    13561 cagcaggaag caccaccaca atatcatctg ctctttgaac atcagaatag agattatagc
    13621 ttcttgataa gacagttagc cgtccgttga ttcttcgctg aacgacttta tcctcgccag
    13681 caaattctaa attgccgaat gttttttcca tgttgggaat cacaaattta agttccatat
    13741 ttttacctat cctttctttt ttattggctg aatgaatgtt tgatggtctt aaagagtggg
    13801 gaacgacctt ttgattcttg attttttgtt ttcataagtt cacttccttt caaaatcggg
    13861 taaaaaaata gacacctcat tttttgaagt gtctacctat taaatattca aattttattg
    13921 gaagtatctt tatatcttca cttttcaagg ataaatcgtc gtatcaaagc tcattcataa
    13981 gtagtaaatt agtagtaaat tgagtggttt tgaccttgat aaagtgtgat aagtccagtt
    14041 tttatgcgga taactagatt tttatgctat ttttagctca ataatagctc tttttaagtt
    14101 cttaattgat tcataatcca aagatgaaga tggttcatct aaaagaataa tttcattttc
    14161 tgaaattcca ctagcagtta tagcaattaa ctgcttctct ccaccggaca gttcaaaaat
    14221 attcttgtct aacaaatctt tactacctaa aacatctgaa taatagtgta ttttatctaa
    14281 aattaaattt ctttctatac atctattttc taattgaaaa gccaattcat ctgtggaatt
    14341 gatacaataa aactgtgttt taggattttg aaacactgta gatataaact tggatcgttc
    14401 taatatactc atccctaata aagatttgtc cttgtataaa acatctcctt ttacatctcc
    14461 acaatcatat tcgggaataa tgccgtttat tacttttaac aaactacttt tccccgtacc
    14521 tgagtgtccc gttataacag ttacctctcc gggtttgaaa tttagattta cattttctaa
    14581 tatgctttct ccatcaaact ttaatactaa attttgtaaa ctaagcatac ttacccctta
    14641 tatataaata gattgcccat accattatca caaaaaatat gcaatcaatg ccaccaatgc
    14701 gtgattcact aatacttgtt cgcttttgat taacagctaa cccttttgtc attgcggata
    14761 ctgttaaatc atctgccgtc ttagacaaac acatcaatag tggcactaat ctatattcaa
    14821 ataatagaat tggatttttt attaactttt taagcgttag tcctctcaaa cgcatggctt
    14881 tttttatctg gctataatca atccttgcgg cataaaagaa acgaaccatc acagtcaatg
    14941 gtattgctat ttcatcggga catttcattt ttttcaatga ataaatactt tcccctacat
    15001 ttgatgtgag tatggtatat ttccccatta aaaatgcggg aagtattttc ttaacaacca
    15061 ttactaatat cagtaaaatc gctaccaagg gactgtattc taatttcatt aaaaatctat
    15121 cagcaccata aacgaacaca agagtagcca tcccaataat agctactctt gtatgttttg
    15181 tatttattaa aagcactatc ggaattacgg atattataag ggcttgcaag aaatacttta
    15241 cttgaatatt gcctaaaacc atcacatatg aaagaactat tgtcataaaa agttttgtac
    15301 gaaaatcaag tttgattgtc atccttaact ccttatgaat ccttattttt ccataccagc
    15361 ctttttaaaa tgttttttta ggaaagccat acctatacta caaccaatat atgctcctat
    15421 aattccacct attgccatta cgacaataat ccaattcggc attacactaa gcatcttatc
    15481 aataaattct tgtttatatc ctcgctctaa catctgcttg acatattcat ttcttgatat
    15541 aaaaattggc aaccaatttc ctaatgtgca aagtggagca acagaaaatg ctaatcttgc
    15601 cttattaaca tccgtatatt ctcctgattt caaaataact tcagcaataa taccagcaat
    15661 aacagcggtc aataatgccc aaggtccatg tcccatagca acatatacta atgcaataag
    15721 taatgattga ataaacacca ttcctctttt tttaatcttt gtggaataca gcatatttac
    15781 aggtcctact aaaactccct gtgcaaatgg aacaaccggc attaaaactg gaaccattcc
    15841 taaaaatgat ccaatcatca taaatacaaa acctaataca gaaaataatc ctatgttgat
    15901 taaatccttt acttctaatc gtttactcat tttaaacctc cctatctctt gtcaatatca
    15961 acaatgtaat ttaccattgt ttcttttata tattttttat gttgtgaaaa agaatttctt
    16021 gcacagagaa cttcagaact taatatcatc gcattgatat aattcactaa aaaaccgtca
    16081 ccaaatatat ctgccttaat tccaagctgc ttggcgatta aacttagctc attagtcgta
    16141 ttaagtttca attcttgata caatttttcc aaatcctgat tatatttttt tgcttgtaaa
    16201 aggagtgtat acaatctcat caattctgta tcagccagcg acttatcaac caaaatatca
    16261 cccatttgct gatatttatc ttttcctcga ttgtttttta aatactcatt tatcaagttg
    16321 tttctataat cattaccatc aagcattaag tctttaaaca tttcgtttgt attaccataa
    16381 tgatgataga cacctcctct actcattcct acctctgtga taacatcttc cattgttgta
    16441 agttgaaacc ctttatttag aaagcatttc tttgcagctt ctcgaatctc tttttttcta
    16501 atttgtccaa ctttttgttt ttcttctttc aaaacaaaga cctcatttca tatcgtaata
    16561 aaaaccgaca ctactgtcga attttatttt atcataaatg atagttaatg tcaactaact
    16621 tttaagtttg aataacaatc ttctttatag ctttgacttt cagcaaattt tattgtaaaa
    16681 ttatctaaaa gttaatagat gcttaatgct tgctatctaa ttcattcttt tgtagcaagc
    16741 acagtaagtg tacggacact tacgaaaaaa ttgatgaagc agccctttgg gatctgcttc
    16801 tttttttatc aatttttaac ttgttagggt gtaccctaag acccgaaata cattcaaagg
    16861 aggatttacc tatggcaaat agaatgcgaa atgaaagact tgaaattaaa ttaactgaag
    16921 aagaaaaggc tctttttgag gagaaaagaa aacttgcgaa atgcaaaaat atgagccatt
    16981 tcattcgcaa gtgcgtttta gaaaaggaaa tatatcaagt ggatttagag ccatttagag
    17041 atttacaggg cttgctttcc aacgctacaa acaacataaa tcagattgca aagcgtgtaa
    17101 attcgaccgg cataatctac aaagatgata taaacgatat gaaaaagcag attgaacatt
    17161 tctcaaaaga gttgtggcag atacattcac tgcttcttaa cagaacttct ggaggtgatt
    17221 aaattttatg gctattacaa aaatacatcc cataaaatca acccttaatc ttgccatttc
    17281 atatattgtt aatggagaaa aaacagacga gcaaatctta gtaagcactc ataaatgcca
    17341 tcaggaaact gctcataccc aatttttaag aacacgaaat gatgcaggaa caaacggaac
    17401 tgttcttgcc agacacctta ttcaatcctt tttaccggga gaaacaagtc ctgaaattgc
    17461 acatcaaatc ggtcttgaac tatgtaaaaa gatattaaag gatgagtacg aatttgtctt
    17521 atctacccat atagataaag ggcatatcca caatcatatc atcttcaata atgtaaatat
    17581 ggtaactggc aagtgctatc aatccaacaa gaaaagctac caccaaatca ggtatcaaag
    17641 cgataaacta tgcaaggata ataacctttc tgtgattgat gagttctacg agagctataa
    17701 gagaaagtac aaaacaaatg gcaagtcatg gtatgaaaat gaacaggcaa agcgtggcag
    17761 ttcttggaag agcaagcttc aatttgacat tgatcgtttg ataaaacagt ctaaagattg
    17821 ggaagaattt ctaaagaaaa tggcggaact tggttatgaa ataaagcatg gaaaacatat
    17881 agcctttaag ccaaaagata agcagaaatt tacaagggct aagacgattg gtgaggatta
    17941 taccgaagaa agattaagag agcgtattac agaaaatcaa tcaattaaag ccccacctgt
    18001 caaaaaacgc attggaaatg tcatcaatat gaataccaat gccaaagtga aagagagcaa
    18061 aggctatgaa tattgggcaa caaaacataa cttaaataca atggctgagt cagttgtttt
    18121 catcagagaa catggcatta aatccgttaa gcagcttgat gaatgcatca agaaaagtgc
    18181 tgaagaaaga cagaacttac aagataaaat caaaaaaatt gacaaggata tgcaactact
    18241 ttctgatacg atggaacaag ttcatactgt taaaaagtat cgagcctact acaaggaata
    18301 taaagcaaat ccttctgata aggcattttt tgaggagcat aagtctgaaa tcacacgcta
    18361 cgaaacagat cttgcaaaac tcaaaaaatc ctattcaaag ctgcctgatt caaaagatat
    18421 tttagataaa cttgataaat tgcaagaaaa aaagaatacc ctaatgcaag agtattcttc
    18481 tacaaaatct actatggacg agctttatca aatacgaaag aactatggga tttacatggg
    18541 caaggagatg gagagataat tttttctctc ctcttttttc aagacaaata aaaaacagtc
    18601 ggtgcagccc taagaccaca ccgaccgtaa atttatctct cagcttcttt gtttgcttct
    18661 ttcttttctt ttggcttttc cttatcttcc gcctgatatt tcttgatagc tccaagtaca
    18721 gattctttct tttcttcttg tcctttcatt tgttcctttg cctttagtag ctttgaagaa
    18781 agtatcctga tgttgctatg ctccttgccg ttatcatcaa tggatgttct gatttgtcca
    18841 aagagcttaa caaaatctcc ctgcttaaag tcctttggaa tatcgctttt ttctccgtat
    18901 gccgaacaat tatgatatac cttattccct tcatcgtctt tggatactac ggagaaattc
    18961 gctaccttaa aggcttctcc gtttttattt tccctttcaa ctacatcgac ctctccaacg
    19021 atatttccta caatatttac aaggttatcc ttttcttcct gaacataagg caggtctttt
    19081 atctgcccct gttctcttaa atcctcaatc atatagtcaa attcctcatg cagcaaatta
    19141 aggctgtcat tgtccatata agcgtcatag agcttatcta aagcactttc attgttgata
    19201 cctttttcta ggcttataat cgcctttaca aagtccttgt ggttatcatt taccatatct
    19261 tctatttgat ttctcattgt tttgtaatcc atgtttttat ctcctttcat ggcaaaaggg
    19321 aggttaccct ccccttatct taaaaattcc tgttcttttg ttttttgctt ttcttcagtt
    19381 ttgctttcat tttgataagc tcttatctgt cctaaaatag atggcttatc ctcagatttt
    19441 tgtgcggttt cttctttgct atgaagattg tcctccacat cataagttga ctcaaaataa
    19501 tcactgtcct taaagtcatt gtcatatctg tcaggaatac cgtcattatc gaggtctttg
    19561 gaaagcggat catagaagtt gccttcatca tcaatttcaa gccctgttgc tgcttttaaa
    19621 tcttcagaat caacatagac taaatcacta aaagaggaca tttccatttc atttttcata
    19681 ttccttagag cttcattttc tcctttactc tcgtaatcaa agctctctgt tttgatagga
    19741 gtatcatcaa tgtactgtgt ccaagttttc tcctctaagt tcagttcata ctgaatccca
    19801 tgcctttcat ctggtgtatt ggtataggcg atcccgatat gctttaagtc aggatacaag
    19861 gtattaaatt catcatagct gtgattttct tcgtactctc tgttacagaa gtcaatgatt
    19921 gcccttttta catcttctac aagtggattg tcatttctct tttcttccac ttctcccata
    19981 tcaaggagct tattcagttc tgcaagtctt aataccttag ttttcagctc atcagctttt
    20041 tcaaaaggct ttttgagttc ttctttggca ttttcaagtt gttcctttgt gctgataagt
    20101 ttttcttcaa gcctatttaa tttctcaggc attttctcaa gagcgttatc aagtcttgta
    20161 atgttaccgt ccacacttgt tccaagctct cctgaatgct ttgcagcacc gtttaagcta
    20221 aagttatgct cattggtaaa gaagttatag cttacctcta aatccatatt tctatacctt
    20281 cctataacct tgctttcatt gattttaacc tttgaaattg cttcaagcag tctttctccg
    20341 gctaatttct tatcggtaat cttttctcct gcaatagtaa tagaagtaaa cttttcctca
    20401 ccttccgctt taggttctac acttgctata tctttcttaa cagcttctat gagcttttcc
    20461 gttcttgcga tttcttcagg atagtttttc gccactttat cctctaatct gtaacggtta
    20521 gacttatagt ttgcttcaag cattttaagt tttgtaacct cgttgtccaa atccatcttc
    20581 tctttaatct ttggatcacc cgttgcaaga gctttaatct ctgcatagtt aagagagctt
    20641 tcgtccacat cttccgcaac acgaacagga gtctttgaag tcataatctg agaaatgaat
    20701 ttctgcttat tctctatcgt ctgccataag tagctgtcaa atgtattctc tgtaacataa
    20761 cgatagatat ttactttctc attttcgttt ccctgtctta caattctccc tgctctttgc
    20821 tctaagtcag caggtctcca tggtacgtct aaatcatgca ttgcaattag tttattttgc
    20881 acatttgtac cagcacccat cttctgtgtc gaacccatta agatacgaac ttcgcctttt
    20941 cttacctttg caaagagttc atctttttgc ttatcggaat tcgcttcatg gataaaggcg
    21001 atttcttctt tcggtattcc catagatacg agcttttctc taatatcatc atagatgtta
    21061 aattctccat ctccttttgg agtagacata tcggaaaaaa gtagctgtgt tgacctgttt
    21121 tcttttgtct tatcccaaat agcaaataca tttttcacgc atacattgac cttgctatca
    21181 ggattatcag gaagaagtgg attgattaaa cgctgatcta aggcaagttt cttaccatcg
    21241 ttggtaatct taagcatatt atcaacatct ggctctacaa ccctatttct gacatcatct
    21301 gctctttcag agaggctctt tagaatttcc ttttgttcct cacttggctc tgtcttaata
    21361 acctcgtagt tagcttcagg tgtaggaaga ttaagcatat ctgccgtctg aatatcagca
    21421 acttccttaa acatagacat aagctcaggc aagttataga actttgaaaa tctcgttttc
    21481 accctatatc ctgtaccttc aggcgataat tcaaaggagg attgtgtttc tccaaaagtg
    21541 gaagcccaag agtcaaaatg ctccagatta tttttcttta agctctcata ctgaagataa
    21601 cgctgcatgg tataaagctc ggtcattgag ttacttacag gcgttcctgt ggcaaagacc
    21661 acgcctttgc cgcctgtcat ttcgtccata tatctgcatt tcataaacat atcggaggac
    21721 ttaaaggctt ctgactgccc tatacctgca acatttctca ttttggtata gagataaagg
    21781 tttttaaagc catgtgcttc gtcaacaaag agcttatcaa ctcccagctc ctcaaaggta
    21841 atcacatcgt ctttcttaaa atcatcattt aatttttcaa gccttgtttc cagttttttc
    21901 tttgtctttt caagctgttt tacggtaaag ttctgatttc tatcatgctt gtattcttct
    21961 acatagttta cgatttcatc aatctgatct tgaatatgct tttcctgata ttccttactc
    22021 atcgggattt tttcaaactg cgtatgtccg ataacaaccg catcatattc ccctgtggca
    22081 atcttaccaa taaatctctt tctgtttttc ggctcaaaat ctttcttatc agccaccata
    22141 atgttagccg atggatatag ctgcataaac tcacgcccga tttgccctgt taaatgattt
    22201 ggtacaacaa acaaggactt actgcacatt ccaagccttt tactctccat tgcggaagct
    22261 accatttcaa aggtctttcc acttcctact acatgggcaa gcaaggtatt tcctccataa
    22321 aggcttcttg ctatggcatt tctttgatga ggtcttaagt caatctctgt attcattccc
    22381 tcaaaagaga gattgcttcc gtcatattct ctgttgcgga ttgagttaaa acgctcatta
    22441 tacagtttta caagacggtt tcttctttcc tgatcgttaa atatccagtt cttaaattct
    22501 tcttttaata actcctgctt ttgtcctgca agcatggttt cttttttatt taagacagaa
    22561 gttttagagc catccggatt tacaatctgg tcaaatacct ttgtttcttt taggtttaag
    22621 gcatcttcaa tcagcttata ggcattaact ctatttgtac caaaggtcat ttctgcaagg
    22681 tcatttcctc tgtccttgct ttttccttct acattccatt cgcttgtaag gttggaaaat
    22741 tttaccttaa tatcccattt ggcatatccc ggagttttta gcgtttcaaa aataaatttc
    22801 tcaatatctt taataggtat ccaagttgca ccaagacgca cattgatttc acttgcttcc
    22861 aattcctttg gaagaacttt tgtaagctct gttttttgat attccaaacg gttcatttca
    22921 tagcttatca gctctttttc tttgccattt tcttcatagc caagatgagg aagttctctt
    22981 tccgtttgtc ttagctttga taagtagctg tctactatga caatcttatc cctgatattt
    23041 ccactcaaat attcatcttt tgttacatag ccatatttat atgaattact gccattagca
    23101 caggcaaaag gtaaatcgcc atcttctaag ttaaaggaaa gtggtctgta aaagttttgt
    23161 tcttctctga tgtttagata gatttcccct cgaagctcct caattaaagt tggtctgtct
    23221 tttccggtaa gacttcccat atagtcaaag tccacatatc ctttttcaga taccgataaa
    23281 acaagagctt ctaaagaggt atccacatgg tctatgattt tggcttttgt aatggttctt
    23341 ttggagaaaa tatctccctt tgccttgaaa ttttcttctt catcaaggat ttctatggag
    23401 gaaacaagcg ggaagttgct atcctctttt aaggctctgg tattgcttag gttattgaca
    23461 aagccatgct ttttagaaaa gttgtcatat acttcattta gtttttcctg tgaagccttg
    23521 atttcttctt cgttaaaatc ttctttctgc ttgtaaatca catcttttaa ggcagcattc
    23581 agctcaaggt aatccttgat tttttcttta ttcttgtctg atacttcctt tttgataaaa
    23641 agtgagtttt ctctgtaata gacttcatcg tcaatcaagg tataagagaa gttctttaca
    23701 tcatcggttg cagggataga agttatttca tcatcaagta gctctatttc ttcatacttg
    23761 gcttcttttg aaattctttc tcctgcaatc tcgatacgct cctttaatga agccatgttt
    23821 atctctgtac ctaaataagc tatcggctca caagtgagtg ttttcccaaa ccttccgcta
    23881 acttcacgca tagaaccaag cacctgctca ggatgatcga caaagtattt gttatatgaa
    23941 agtccatttt catcttccgc aaggtgtatc caatcttcat ctcgctctaa tacactatct
    24001 cttttcttta agaagataat atccgaagtt acttctgtgc cggcaacacc cttaaaggta
    24061 tcgtttggaa gtctgattgc tcctataaat tcggttcttg ctgcaagata tcttcttaca
    24121 ctttcgtctt ttttatccat tgttcctgaa gatgtaataa aggcgataac accgccgttt
    24181 cttaccttat caatggactt ggcaaagaaa taatcgtgga taagaaagtt attacgattg
    24241 tattccctgt catttacctt atactctcca aatggaacat ttccgattgc tacatcgaag
    24301 aagttattgg aaaatcccgt ttcttcaagt ccctttacct gtatatcact ttcagggtat
    24361 agcagctttc caatacgacc gcttaccgaa tcaagctcta ctccataaaa ctttgactga
    24421 ttcatttcat caggtaaatt accgataaag ttcccgatac ccattgacgg ttcaaggata
    24481 tttccctgtt taaatcccat acctgaaagc gtcttatata cgccatctat aacggttttc
    24541 ggtgtgtaaa agctcgttaa ggttgattct cttgcagctt catattctga tgacgataga
    24601 ttttccttta agaaggctct tgcctctttc cactgtccat ccttactttc atcaaagaca
    24661 tcagcaagtc caccccaacc aacatatttc gctaaaactt cctgagctgt aatatcaagc
    24721 tctcgttctc cactttccac cctgttgagc atagagattg cttcaaggtt attgtttaac
    24781 ctctcacttg gaaataactt tgaaggaagc gtttcttctg taatcttgaa attgtgagcc
    24841 tgatttttct ttatctctgc ttcctcaaaa gtcttttcag gtttcgcata agtcaaattt
    24901 tcaaagattt taccaatctc actttcctta cgataaggaa taacatcgga gcctgtaatc
    24961 atgcctccaa gatattcggt attatcctta atcgttactg tctttaggtt atttcccata
    25021 tcatcaaatc ttgtgatggt atagtctttt cccttatatt tcacttcatc acctatgata
    25081 aagtcaggtc tttcaagact tacttgtctt aataaatcct cattatcagt aaaggctaca
    25141 atcggtattt gatgattacc ttgccttgca ggatcaagcc acaaatcatt tcttcctgtg
    25201 attggatttt tggaaatctc tcttactttg tactcctcat gattaaaata gacggtatca
    25261 tcttctttaa ctgcaaactc atctgaagat ctgtcctctt tttcattaag ctctacttct
    25321 tctttttcct ttagataatc taataaggta gcctgaaaag gttctgcctg tatgctttct
    25381 tctacttctt caggtgcttc aaggtctgca atattctcct caaagctaag ttctccgtta
    25441 aatacattgt gaagctcctg ctcatccatc tgctttttaa gctcactgtc tctaagttct
    25501 ctaaaggtct ttggaaaatc ctctaaaatg agcctttgtg catttagttc ctttagctct
    25561 tcaagattaa aatatcccca ttcaggctct attccaagca caagtccaaa agcgtcttta
    25621 ctttccctgt catattccgt catataccaa gtccagttac ttctaaatgg aatgatatat
    25681 gctgcatgaa cctgtttatc cgctaaagct acatcctctt gtgcataaag ttcaggaact
    25741 ttctcaagca tttcatcagt cattagatta tatggatcgc ctttagagta ataacttggc
    25801 tctttttgtt cttctatcgc tgtcttgctt tcaattttat tctcttcaag ataaatattt
    25861 ttagaaagca gctcatctat atgctttgct acatttgacc atgtaagaaa aacatcgtta
    25921 caatgattct tctgtaattt cagtcccttt gcatcatgcc attcatcact tccctttgct
    25981 cctgaaacag catgagaacc tccaccgatt ccatactcat cttttaagaa attcgctttt
    26041 tcctgcaagg tatgattttc tttgaaaaac ttaataattc gctcttttcc tctatcaaag
    26101 ccgcttcctc ttgaaatcgt agcaaggact tcatcttctg taataaagcc ttgtaccttt
    26161 ggaggttcga taaggttaga agtatattcc tttcttgtaa gttcaagctc ctgcaatttt
    26221 tgataaaggc tatctacctt gtgataatga aaccttagta catctctatt ttctttgtat
    26281 cctgctaaaa aacggctgta ctcggaaata acatttttta gatagtcagg atttttaaga
    26341 gcttccgata actgtcttgt ttctttagga aactcacctc ctctttccat aaagtcaaaa
    26401 tatccctgtg ctttcccttc ttcacttaaa tcgtgatata aataccataa ggattctgaa
    26461 actctatctc tttcatagtc atgtgcttcc aaaagctcta catttgtggc aaactctcca
    26521 ttttccaaaa gctcattgat tcttcttaca gcatcactcc agcttaaaat ttgcgtcata
    26581 tcttctcttg cagaagttcc ataagctaaa tgaatacctt tatccgaata ccaggaagat
    26641 acttctgctc cattaagaaa taaaccgttt ccgcctctaa aggtatcttt aaggtattct
    26701 cctaattctt ctactgtttt ccctttggaa aattcagcaa tgataggaag tctttcgccc
    26761 tcatggtttc caccgtttac aagaatactg tcaatatcat tttgtgtaag aggtattgta
    26821 agtttaatct gtcctgatct gttttcgggt aaagaaaaag aagccttgtc agcttctctt
    26881 atctctttat ccgtattttc ttttagattt ccactatttc cttgattgtc atctctttga
    26941 gggctgaaat catcgctttg tactgcggat ggctctcgtc ctctatctcc caagctgcca
    27001 tcagtttcgg cttctctgct ctcataaatt ctattgcttg tttctgcgta tccatcagat
    27061 gccctatcag tttcttctcc ttgtatagat ccactaacat ctcgaagttg ctctgctcct
    27121 cgctgtttga aagataatcc agtctcatca ctgcgtatgt cggattcgga tattccctca
    27181 taaagtccat ctcttcctcc aactgattca gtgtattctc tttgattttc tctattatct
    27241 cgtccgtact ctccatttcg gaaaattcgc tcgttttcac taattctttc ctgatcatct
    27301 cgtcgaagta cattttcttc tacctcctct aatttttctt ttattttatt atatcctgct
    27361 tctttacctc ttaaaacttc tttttgaagc tctaattctt tgcttttttg aatggttgca
    27421 tcaatgactg ttccgctaat atccgataca gtttctccaa ggctcataag agaaatgctg
    27481 tcaagcattg caaagttttc ctttaacagc tccttatcca ttggatagtc taacttaaat
    27541 cttgaagcta ctgcataact taccgagtcc cttgcaaact tggtaaagga tattctgtcc
    27601 tcatcagata ttctaagttc attcatcaag ctatctattt tttcatctcc gtaaagccta
    27661 cttaaagaaa agatattttc taaggtgctt tcactttctt catagccttc agcttttatc
    27721 atttctttta atacatctct atgagcttct ttatcaaatc tccaaagatt tacctcattg
    27781 acatctctgt ttttggaaac tgtctgacta atatcaaaga tatagtccac ctttttgtat
    27841 gtgccatagt cctctaaaat gggaataccc ttttgacctc gcatgacagt tcggttaaag
    27901 tgttctctcc agtagtcaaa cttggcacaa gctgtcgctt caggattttt atcataaata
    27961 cttaactgac ttctaaaatc gtacttctga ttgttcccga caacttttaa gagcttcaga
    28021 tactctgctt cactctgcag aacatcttgt tttatcagct ccaaaatgtt atgaaaatca
    28081 tttattcgca tgtttacctc cttctttttt tacaaacaaa aaaggcggtt agattttact
    28141 ctaatcacct ttaaattctg tgtgctacaa cttactgcta ttcattcagt tcccaatgac
    28201 cattacttcc acttcctaca tattgtagat tatccatttc tttaatggtt ctttctatag
    28261 tctttacact aactccagct tcatctgcaa ttgcttttct tgtaatcttg ttgtttcctc
    28321 ttattttttc ttttataaac tctgcaagag ctatcttatc gtgagcgaca tcctgagcga
    28381 cactgtgagc gacatcctga gcgacaccgc ttcctccaac tttttgagtc gctattttct
    28441 tcaaaggaat aatcgttcta aatatatctc cctcctcaaa cagaggatca acacctgaat
    28501 atagccttgt atatttatag gtgtttctca tacctgaacc aagctcatca gcaagtccta
    28561 tttctctaaa tacttttgaa atagccggat ttttaggaaa aggttcaaac ttttgtaaat
    28621 ccaatgctcc catgccatga gctaagttac tgttttcaat cataatcttc tcatcgtcaa
    28681 taatcatttt tgcagggaaa ccacttgaat aatctctgtg agccaatgta ttagaaacaa
    28741 tttctctaag tattctatcc cttgcattga catttacaat tccgtctaag acaaataagt
    28801 cattcaaatg cttctgtcca aacgcaataa gcctatcgta gctatcaatc agatttgtta
    28861 tgacaacatc tctatcgtca tacctatcct tgttttcaac tctaaatatt gcatcagttt
    28921 tatgctgtgg gagaactgac ataatagagt tgtcttttcc aaataacaaa attgccgcta
    28981 atgtaatgcc ctcatgcttt gtttcaggat ctgtcagaat gagatttgca cttcggagca
    29041 gttcctcata actcatattt tcccagacat gatttttatt tcttgctact gccattctct
    29101 tggctttatc aataacatca gtatcaagaa attctatatc gaggtttgga tacaccttat
    29161 tcacaaaata gcttccctgt ttcctcgcat atagcttata aacaagttct gcatggtctg
    29221 tgatattgat gtctccttca taagacctgt cccatattct tccgttatgc ctgcatacct
    29281 gataaccttc aggtactcgg atataaatca cttttttact gtcaagctca aatacttccg
    29341 gtaataaata aagtggtggg tacatcttct gcgaattgtt gatagatgtt gtaaattctt
    29401 taataatctt gtcaacttta tcttcactaa caccaacaat atctctttta tcatttacac
    29461 caagtaaaat atgtcctcca tttctattgt tgaaagagca tactgtatca aagacatctt
    29521 tggttagagc attcctcgat tctttaaatt caacatctat cttttctcca ttttgaatta
    29581 acttttttat ttcatctata gtcatctttg ttgtttcacc acctttattt atcaatgttt
    29641 tcttcaataa aagtcttgga gttttgaatt tgcactttat ctttattgac tacaaaagta
    29701 acataatctc cattttgtaa gtccaaaagt tctcttatcc tttttggaat agtaacctgc
    29761 ccttttgaca taacttttgc agtatccata aatgtatctt tcatacctgt ttcctttctc
    29821 cctacttttc ctacaaaaga ttatatcatt tttagggcat tttttccacc ttgaaattag
    29881 tggcatctta cttggtataa gtggaaacca cttcttttat ctcattttca atcgcttcta
    29941 aaaagttttc ctctgaagat tgcccctgtg caatatccga taactccatt tcccactttg
    30001 ctgttgtttc tgctgattta aaagtatcgg ctacaatcgt tacaaggctg attcccttat
    30061 gtgtagcaat aaggttcttt ttatctcttt ctacaaatcc cttgaaaatc agattttcaa
    30121 taatccctgc tcttgttgca ggtgttccaa gtccttttcg ctcaacttct acaccttttt
    30181 ccaatgcgtc atttcctgca agctccatcg cctttaggag aagatcttcc gtaaaatgct
    30241 tagctggttg agtgtatttt tcttttatct ctttatcttt aatatcaaga ctataaccaa
    30301 tctttacatc cggaagcact gtatcttcat ttttcttttt cgcatattcg tttaggtatt
    30361 tggtaaagcc atcatctaca atcacctttc cactacttgt aaattcaaat ccatcaaatt
    30421 cagccacaat cttcgttgta ttctcaatta aaggatagcc tacacttgca tgtagcttat
    30481 ttaaaataag ttcatatacc ttcaattcac tttccggaag agaagttaag ttctcattca
    30541 tactgcttgc tgtcggtata atcgcatgat ggtctgtaac ctttttagaa ttaaataccg
    30601 tcttgatacg ctctgtgtca aaatcattct ttcctaaaat gttattaacc gtacttacaa
    30661 tcatatcttc cgtaaggcat ctgctgtctg ttcttggata ggtaatcagt ttcttttcgt
    30721 aaagactttg agcataatca agtgtctgct tagctgagta tccaaaatat ttattgcact
    30781 ctctttgaag cgtcgtcagg tcaaatggca gctcaggctt tgttatcttt tccttttgaa
    30841 taacatcggt aatttctatc ttatcgccta ctaaatttaa gagctgttcc gctgttattt
    30901 catcatcaat tctatctgtt gatagtgtaa agccattaag gcttaattcc actgtaaaat
    30961 atttttcttt cttgaaattg gctatctcac catctctttt tacaatcatt gcaagggtag
    31021 gtgtctgcac tctgcccaca ctgtaatttt gcttgtatag acacgaatac agtctgctta
    31081 aattcattcc cacaagccaa tctgctattg ctcttgcttg tgcagactca aatagattat
    31141 cgtaagaact tccatctttt aggttatcaa agccctcttt tatggcacta tcttccattg
    31201 atgaaatcca aagacgcttc attctctttt tacaatttgc ctgattatat acaagcctga
    31261 agatggcttc tccttcacgc cctgcatcgc aggcatttat cacgatgtct atatccttat
    31321 cattcatcag ctttttaaga atcgtaaatt gtttctttgt agactttgca atctcatact
    31381 tatattcctt tggaataatc ggtaaatccg ccatattcca cttagcatac ttttcatcat
    31441 agctttccgg atttgccatt ttaattaaat gtccaacaca ccagcttacc ttatatccgt
    31501 ttccttcata atatccgtct ttcttctttg ttgctccgat cacttttgca atagaaattg
    31561 caacacttgg cttttcagca attactaaat tcatctattt tttcctcctg tttttcaaaa
    31621 taatagggcg gaagatgtta ctctcccgcc ctgtcttttg caccaaatat tgtatagttt
    31681 tgggtgcaaa tttattccaa ttcatcttct ttatcttctg tttctgtttc atctacttca
    31741 ttttcacttt cttctgcctc tgaaaagaaa tcatcatctt cctcctcaaa gccttcaagc
    31801 tccttatctt cttttttctt aacgaccttg aaataatatc ctgcacctaa tgctcctgct
    31861 actacaagaa tgagaattaa gtaggttccc atattgctgc tttcttcttt ttttactggc
    31921 ttaggttctt ctttttcagg ttcttccttt gtaatttcct gttttggagc ttctttcttt
    31981 tcaaccatat taagaagatc atcttcggat acttctgtta ggagcatgac attttcgcta
    32041 tcctcatcgt gattgatgat taaatgaaag gtcttgccat tcttagtagt aaaggtaaca
    32101 aactgtcttg catccgctga atacatatcc gtttctttat tatctttact gtcattatgg
    32161 tgtattggat aatccttgtt cgcattatcc ttattttccg taacagttcc tcttgccttt
    32221 gatggtgctg acgcaactcc tttattggta tttacattct tacttgaacc atccatagag
    32281 gaatcctgac tgctgttatt ggcaggctgt ttcggtgtca gcttattggg ataacgaact
    32341 tctttttctt tgtcattatt cttaccaata tttgtgtcct ttgtaatctt tcctgtatta
    32401 tcctgtgatg atgagccttt acccgtatca cttacagatg tttgaggaaa gtttcctgtt
    32461 cctgttttca ttccggagat agggctgatt ggtgttacag taggattatg cgtaactgta
    32521 gccttgccaa cctcattcgt ctttttctca agctccttaa ttttctcagt tagcttctca
    32581 atctcctttt taatatccgc cgataaatcc ttatcgtctt tgcccttttc aagtttttcc
    32641 ttcagcttat ctattttttc ctcaaggtct ttgattttct ccttttgctt gtcgcttaat
    32701 ttatccttgt ccttaatctc ctgatttagc ttatcaagtt tttcctgaag ttccttagat
    32761 tccttttcca ttttggaaat gtcatctttg ctaagctctg tttgaattcc cttatcttca
    32821 gtttttggct tttctgtctg cgtctgagca ttactttcta acttctttac aattcggata
    32881 atactatcgc ttccatcacc ttttactgtg tagcttacaa aatcgtcatt aaaactcata
    32941 ttatccggaa gcatttcaag atcagacgca tcaatcatct gatttttgtc aaaggaagct
    33001 gaatactcct tatatacatt tccgtcctga tattgatatt tgatctttac ttcacttttt
    33061 gtctgacttt cctcatcctt agtatcctta ttgtctgttt gagctgacgc attcgctacc
    33121 ctcttatata aatcctctaa aggtaattca aggtagggta caccagtatg aaatctattc
    33181 catgtttcaa taatcagctt gtccttaaca atcttaattt cttttacatt gttgatattg
    33241 ggatttgctt cttttactct gccaataata gaattctttg tttcctcttt aaactctccc
    33301 tcatagtcaa cagttacttt ctcaatattt ctatttaact gtagaacagg gcaggtatag
    33361 acaatgacat ttgctttctt tccttttacg gttcgttctt ctgcattttc tgtaatatct
    33421 ccaatatagt aattatcctt atctcttgga gaaacgatac ttgtaaaagc acctgtccct
    33481 atattatgaa ttcgataata tggatagggt ttctttgtca tatatcttag atcatctaac
    33541 tgatttacct tgtccatatt ctcattggta aaggtttcat tatacttatc gacaactaca
    33601 ccgccctttt cttcaaagga ttttgataag gaaaatttaa agttcaatgg ctgaccttcc
    33661 ttatttcctt ttccgagatg ataaaatcct ctaaaggtgt catctgaagt atgatcctca
    33721 aatttcagtt cataatatgt ttcatatttt tcaggcggtt catttgatgc aaatactgtc
    33781 tttgcaccaa cttttaacac ccctaaaact ccaaccatta gcagggtaaa agctacaaca
    33841 atggctgtaa ttcttttatt tttcaaactg gttttcattt gttttctcct ttttcacttc
    33901 tgctttttct ctgtttactt ttgccattaa atcactgatt gtaatgttgt tctttctgca
    33961 aatggcaata atttcttcgt tttcaagttc ttcctcacga atgaacaaag gctccaattc
    34021 ttcatcaatc agagcctttt tatcttttaa tttctttatt ctgtttttta ctgctgtaag
    34081 ttcttttttc aaattgtgtc ctccttatct gtttacattt ggcggaaagc cgaagcctac
    34141 tggatgatgc tgacaaaaag atgctatcca atcatctaaa gttgttactc tgattcgacc
    34201 gatattatct attactttgc catcgcctat ataaatgcct acatgaccat aagtaagtcc
    34261 tgctgtactt ccgctgctac tactttccac cgcaacaagc attcccacct tgagttttga
    34321 tttgtccgat gtaaaggtgt agtttcgata catatcacag gcatttccgc caatatatcc
    34381 aagtcctgca ttttgataga cctgtgatac ccacatggca caccagcctg cccccggaga
    34441 tggcgtaatg tatgcagcat ttacaatctt cttttgaact tccgtagaag cctcatactc
    34501 ttttccgcct ccgatacctc cattggaagc aataaggtcg ctattaccaa aggcttctcc
    34561 catattgcct tgagcaagga atagggcttc atagtgcttc agattgtcag gatagtttgc
    34621 aaaaaccttt ctgataatgc tatccatctc ttttttatga agcgttacaa tcagtttctt
    34681 gtactcgtaa ggttcttcat ggctttcggt atattcattt ccatcttcat cggtataagt
    34741 ttctgtaact gtcctatatc tgatttccac ttcttcctta tactcaaggt catacatgga
    34801 cttaaaaagc tcatttaata cggagcttac ttccgatgca ttctttactt ccccgcacct
    34861 tgatgtaatg taggataaaa gctcgtggac attatgaccg atgtactctg tgttatttag
    34921 gatgtactca tcatatccgg gataattttc ttctacattg tcaacctcac tttgaagctc
    34981 cttttccatc tccgaaaaat tctcattgat ttcacttagg acatttggct ttgacaaata
    35041 gcttgttgta agaacagaac ttgtggagtt cataaagcct gtcattcctg ttcctgcaaa
    35101 gttgataaag aaagttccca aaataataag acctatgaaa ataatcataa gtcccttcgc
    35161 ttttcttaat ataacttcct ttgaactttt aagacttcct ataagccctt ccttaatgcg
    35221 atctctaagc cttgacttat tcttcctttt aatggaatct ttcatctgct ttcgcttctg
    35281 aaatcgctta aagttatttg ctttttgata ctcctgtgtc tttttcagct cctctttggc
    35341 atctcgaaac tcaagtttgg attttctctt tctgatttta tagtccttat tcgtaaggtc
    35401 atatcctttt tttgcttttt tcttatccga gtagttctta atgccatgaa tgagctttga
    35461 gcttgtatct gctgtcttct ctcctgcctc taccccttga ttttcatcgc ttccatgaga
    35521 taggtaatct cttacggttt cacttccttt agcaagtcct gataaagcgg acactttaga
    35581 agtcttattc ttaaaggctc tttcctgttc tttagaaagc ctgtttttct tttctctatc
    35641 aagaatggct tcttttccgc tttttttact atccgccttt tcctctttgg cttctttatc
    35701 cttttttctg gtatagagct tatcagaata gttttttctc ttataatttt tcttttgagc
    35761 tttttggctt tttgaaaagc cttttgtatc ttctacttta tgttgcagat tatcctctac
    35821 atcataggtt gactcaaaat agtcgctgtc cctaaagtca ttgtcatatc tgtctatgat
    35881 tccgtcattg tcgaggtctt ttcctaaagg atcatagatt tttccatcct taacctcagt
    35941 atcataatcc gctttcccga tttcttcctg acttacactt cctgtttcag gacttctata
    36001 ccttgcattt cttttagaag tttttccgtt taattcagtt tctgcacttc tcttactgac
    36061 cttttcatga accttatctt gaaatctgtc tttgtcatgg acgattttcc ctctgtaatc
    36121 atcgttatgc tttagcttat tttcttcagg ctctatgctg ctattacttt gcagcctttc
    36181 cttttcaatc cttgcccttt gcctttcctt aaagtccttt ttcagtttct ttcccataag
    36241 cctacctcac ttcttcaggc ttggttgtca ttttctgata aaggattgtg tctttcggga
    36301 atttatcaag gaaagggaca atggtatttc caaagaacaa aagtccttct cctgcattgg
    36361 aattggttac atattttagc tgtggctgtg agattttaag tttccttgct aaaatctctc
    36421 tatctcctga agcctgatta agcattaaaa caaagtccgt attatcaaag atattttcaa
    36481 tttccttgct cataagtaag tctttgacat tttgtgtaat gcctgtcggg attcctcccc
    36541 acttacgaaa tcttttccaa atttctacgg aataggaagc tgtctgctca tcttttaaca
    36601 ataagtgaaa ctcgtcgata tagtaccttg tagccttatt tcctctgttt tgcgatacct
    36661 tattccacac ctgatcctga ataacaagca ttccgatttt tttaagctgt gagcctaact
    36721 ccttaatatc aaaacaaagt agctgcttat ttaagtccac attggactga tggttaaata
    36781 catttaagga tcctgttaca taaatctcca tttccgttgc cagcttttta ccgacttttt
    36841 cttcctgatt tttgagcata tcatacaggt tttgaagaat cggcatatta caaggctttg
    36901 gattttcaaa atacttttca taaatcttag gaaggcatct gtctataacc gacttttctt
    36961 ctgctgtaag accactaccg ccaactacta attcaagcat cgacataatg aagtttgctt
    37021 tatctttcag tggtgcgtcc ccatcgccat agttcatatt tatatctaaa ggattaaggt
    37081 agtcttttga cttactgctg acctttatta cttctccttt aaactgacga acaaggtttc
    37141 cgtactcgcc ttccggatcg cagataataa cgtcatcatc cgttgtaaga atggcatttg
    37201 ccatttctct ttttgcacta aaggatttac cacttcccgg agttccgaga attaaaccgt
    37261 tcgggttttt caatttcttt ctatcagcca taatcaggtt atggcttagg gcatttagtc
    37321 cataatacaa actgttcgcc gaatttatga aaagctcctc tgtggtaaaa ggcataaata
    37381 ctgccgtaga tgatgaggtt agtcctctgt caatttcaat cttatttacc ccaagtggaa
    37441 gtacactgat taagccctgc tcctgtgagt gatcaagtct ttttaacttg caattatgct
    37501 tattggcaat ggagctgatt tgagaaatgg tattgtccag cctttgaatt gtccttgcaa
    37561 agttcataaa gatgatggtt acgacaaaca tacgctcatc tcttgtctga aggtctttta
    37621 agaggctttt tacatcttcc ccataggtga ttaaatcact tggaagaatg tccatatcat
    37681 aaccgcttct tacagccttt ttattctcct caatcttcat cttgtcaata tcggtatttt
    37741 ttctttttac catcttgatg gcttccgact gttcgattgc cttgatatga aaagagatat
    37801 tgatgttatc gtctatatcc aaaaactctg caagcatacg gtctgaaagc tcacttgcaa
    37861 ggatttgaaa atgacttgct gctccgataa atttcccaaa cttaaaatac cttgacggtg
    37921 taaagttaaa ttcatcagga gcaatatatg tctttgtgct ttctttcttc tttaagtcct
    37981 tatatgaaaa ttcaaaggtc ttattgggat ttaaaacatc atgaagtatc ttcagccttt
    38041 cttctccgtt tagactttct gctcttactc ccatactttt aagacttgat aatatatcta
    38101 tctccagtct ttcaagtttt gatgttgcct gctctaaatt atccgcttcc actgtaaagg
    38161 ttacatactt tgattttttc agtccgttat ttccctttac aatctggctt ttcagcattt
    38221 ctctaaactc aaggcgaata tcgtcaaaac cgtccttttt atccggtatt tgaatggctg
    38281 atttcatttc ttcatttctg ccaagctgat taatatatga aaactctatg ctgacacttg
    38341 gatcaaagga attaagaaaa tttgcaaact gattaaaaat caaatctcta tcttcttcta
    38401 aggcaagctg atagtttata tcctcaaagg caatactctt attaaaatgc ttttcatcaa
    38461 tctgacatat cccgcttttt aagagtctaa gatagggaat ggtatcttca acagtgtatc
    38521 ttttcggttc tttcctaaag ataaggtcaa gtaatccgcc cctatctttt ttagactttc
    38581 ccttattttg ctttaagtcc tgtttttgac ttcttaactt cttttggttt tgttctaact
    38641 ttagctgctg aatttttctt ttgtctttca agataaacct cctttctcac tcttttttgt
    38701 ggctgataaa atttgtgaag gtaaatatac ttaaaatatt tctcaaagct aagtccgtcc
    38761 ttttcaaaaa gagttatgaa aaatataggg agagtggaca caatgagaaa gatgactgct
    38821 atatcatttg gaacgacctt tcgcataaat aaatagattg gtattccaat aagtcctgca
    38881 atcgtaaaac ctataagctg tcttttcgtc aaattgaatg caacctttgt ttttaccttc
    38941 tttaagtctt ttgggatagg tacatacgcc ataacttacc tcccatcttc ttttcccttt
    39001 gaaagctcct ctatatgctc atatacggag ccgatttctt cctgaatact tgcaatctgt
    39061 tcatctgtac ttctgttata tctttcctgc attagacaaa aatcattgtg gcagcgaccg
    39121 atgtcttttg ttctttcttc caaatcattc tctttgatgt gaagcctgat tctatccatc
    39181 actgccaaaa tacctgttcc aactgctacc gctatcaata ctgtttttct tttgttcatc
    39241 atatctatcc tttcttttag tgtgcattta atacgctttt ggccagtgtt ccgctcttta
    39301 gcatcattaa ccccagcaaa accgcatatc caagtatcgt aaaggtactt gtgtgtatat
    39361 ctgttatttg tattgtctta actaatactg cgtatattcc aagacaaacc attaaaaaga
    39421 gtccttgtaa tcctatggca aataagcctt tgatatagtt tgttccgatt tgtccccact
    39481 ctttgtttcc cattgtggca aaaggaatgg ctgaaacgga tgagtaaaca taaatctcaa
    39541 acattctgcc gtataccaca agcataatca caatggaaat gacctgtatt gccaccttta
    39601 tgagcgaggt ttcaaagagt atcatgacaa gctctccaag acctttatct tttaagcctt
    39661 ctaccatcgt tacaatctga tctccagaga taacggcaga ggtgttaatt acccctgccg
    39721 ctttatttac catgtgctgt gccacatcaa agactgccat agaaaactga aaagcatggg
    39781 acactaacca tacggcaatc cacatcttta tgatgtattt gaaaaattca aaggtatccg
    39841 tatcgtgcat attgttcttt tgcataacca tattgataag ctcgatacaa aggactgccg
    39901 ttatgattag ccctgcaatg gggataatga cagagtcgtt aatgcttttg ataaaactaa
    39961 aaacctgtcc attccacccc atcggtgtct ttcccacatc cgttgcaatc gcaccaactt
    40021 tatcgttgat gtcaagaaac atggactcta agtttgcttg gataccgccc agtagaagat
    40081 ctttgaaaaa ctcctctatc ttgtcgaata tcccaaacat ttaatttctc cttttcttct
    40141 tacttgagta catttgcaag aagcggaatc agctttaatc cgataaggac aataccgcct
    40201 cctgccataa gctgcttaat gccctgagat tttgcacccg gattgtcatt accataacct
    40261 tccatcaggt taataacgcc ccatgctcca agtcctgcac ctactgccat aactaaaatc
    40321 tttaatacat ttactgcctg tgtaaaaaat tccataattt attcctcctc gttttcttct
    40381 ttcttttcaa ttttgttgta tgacttcaca acaaagtttt tgtaagtctt tccatctttt
    40441 tcacgcttct taaagtatcc aaagatatgg atcaaatcac ctttttcaaa ggcttttgct
    40501 gtttctgact tttcaccata ggctgcacaa ttgatatatt ccttgccttt cccatacttt
    40561 tttacaagcg taaagtttac aacttcaacc gtttctccct ctttgtcaaa acttgaaaaa
    40621 gttggttctg ccaataagtt ggcattgatg ttaatcattt cttgcttcat taaaaatttc
    40681 tccttttctt ttcaataaaa aaagcgatcg gagtttttct tttccaatcg ctgatactct
    40741 tgctatttag ttttccttag tgggacttct tatccttacc atctttcctc ctgattttga
    40801 gtaataaaaa agcagcaaat ctatgttctt tagacttact gcactcttgt aataaccgtt
    40861 tctctattta attttgcttt cccttttctc ttgatatatt cctcaatatc aaaggcattt
    40921 ttcttattaa aatcttcaag taacttgtaa ttcttatgct ttgtaatatc aaatttatct
    40981 gataaaaacg gtcttacacc tctaagctga aagatacatt tactgccatc cataaccgtt
    41041 atctcatctt gactcatcag ctcttttcct gtcttttggt aattgagtcc ataactatta
    41101 gcattggagc gtgtttcaga agtgttatat agatctatcg tttcctttcc aagcgtttct
    41161 gatagctctt ttaatgtggt cttttccttt ccacctaaaa acaatgtact atcacagttg
    41221 cccacgattg tgtcagcatt atccttatat atcgccttta actgagattg tgcttgcaaa
    41281 ataatgcttg cagatatttc tcttgaacgg attgtcgcta ttaacttctc aaactttgga
    41341 attaagccga tatttgcaaa ctcatcaaga aggcatctta catgaacagg taatcttcct
    41401 ccatactcat catctgcctt atcacaaagt agattaaata actgtgagta catgatagat
    41461 accacaaagt taaaagtatc atctgtatca gatataatga caaaaagtgc tgtctttcta
    41521 tctccaagag tatcaagctc aagttcatct tctttcatca agtccctaag ttcctgaata
    41581 tcaaaaggag caagtcttgc accacatgaa ataagaatag acttcgccgt ttttccagca
    41641 gcaagtttgt atttcttata ttgctttacc gcaaagtgcg taggctcttt cttttccaat
    41701 gcttcaaata gtctatcaat gggattcata tatgtttcat catcttccct gacttctgaa
    41761 gcatctatca tatccagtag tgtcgcaaag ttcttttctt ctcttggagc ttcataaaaa
    41821 atataaccta tcaaagccgt atagtagagt ttctcggctt tcacccaaaa atcctcacct
    41881 gccttttccc cttcaccctt agtgtttgca atgattgtct gcactaattt gaggatgtct
    41941 ttttcacttc tgagataggc aaagggattg tacttcatac tctttttgaa gttgatggta
    42001 tttaagattt ttatctcata gccattatct tcaagcatct tgccacactc aatgactatc
    42061 gttcctttag gatctgtaac acaatatgac gagtgcattt gcattaggtt tggctttaca
    42121 taaaatctcg tctttccgga gccagaacca ccaataacaa gtacattctt atttcttgca
    42181 tactttggat ttgccggtct gccattcatg gttaatcgct ctgtttgagt aagcaagata
    42241 ttgttttgga acttttcatc cacatacggc tctatatctt ttctcgttcc ccatcgggct
    42301 gaaccatact ctttcccctg tctgaacttt tttgcatttt tacctttggt atagacaata
    42361 aatttaatta aaactgccac ttccacgccc attaaaatat ctattggatg aatgctcgga
    42421 ataaagctca tggtattaag ctctaatatt ccttgaaata ttttatctat tacatcgcca
    42481 cctgtatagg ctcttacatg gtgagagaag atgtttccaa catagaaaaa tgcaagatag
    42541 ggaatattct gcttgaaaaa ctttgactta tcttgcacct taaataagcc tttgatgtct
    42601 tttagtatct tatctatcat aggctctgct ccttttgttt attcttgact ttatctttag
    42661 aaagagcgtt ctttgccatt tccttgaact tctcaatatt cttgtggata gattcttttc
    42721 tttccgtttt cttttctgat tccgaaagag cgtgtttaaa ggctttatcc atgactttca
    42781 tgtcttttgc ctgaaagaat acggagtatt taccgctttc tttatctttc atcaccgaaa
    42841 actttacccc ataccgatta agttcctttt tcagttcctt cagctctgct tcttctaccg
    42901 gaatttcttc aagctgtccc tttttaacca tatcttttag ctttacttca tttccgttag
    42961 cattaaccag cttttccagt cctccaagtt tttcagcctc tttcatcagt ttctttaata
    43021 agttcagaat tagctttcct gttactttag cagctttcac ttccatgtta agcgtttttc
    43081 ttgcgatttc ttcattgatc aagttctctc acctccagtc agtaatcttt ctttattcct
    43141 ctttaatttt tcttcctgaa taactttcct gtaattttct ccgagtacca tcacaggaat
    43201 acacatctcg ataattcttg agtaaattct ttggtattcc acactctccg tacagttttc
    43261 aatttggctg tatgaaagat ttgtggtaaa gattgttggc ttatgcttta agtacctgtt
    43321 attgacaatg ttatatacct gctctttggc atagcttgta tctctttcaa ttcctaaatc
    43381 atctaagatg agaacggaag tgtttacaag ggattcgata tatgcgtttt tatcaatgtc
    43441 aaatcctcct ttttgcagtt cgttgattat ctgtgaaaag tttctaatct taacgcttat
    43501 ctgatactgt tcaatcagtg cattggcaat agagcaggca agataggtct ttccgcttcc
    43561 aactgttcca tagaacagaa gtccgatatt ttcctttttc atcaattcat aatcttttac
    43621 aaaattcttt gcgatgataa gactctgatt ttcttttccc tgatagtttt caaaggtata
    43681 tgaccactga ataatagatg tgaagcagat actttttaat ctctcgattt caagctgctt
    43741 ttgtctttct ttttcttttg cttctctatc tctatcgcat ttacaagctg tcttaaatat
    43801 catctgcttt ccgaaaaatt ctaatgcttt tccatctttt ctttcatggc acactttaca
    43861 gtaggcgtgt ccgtctttga tgtattcttt ttcaggattg aagctgtatt ccacatcttc
    43921 tatcatcact ttttctaatt ctttaatcat aaatgtactc ccttgttata ttcctcccat
    43981 gtagggatat tggttttttt cttacttccc tgatctttat aaaaccaaga aaggattgtt
    44041 gctttatggt ctttatatgt ctttccggta ctttgaagat aggttgatag tctttcaatg
    44101 tagttatcaa gctctcctgc cattattatt tgtaattctc ctatgtcttc gtcctttaaa
    44161 aagacatttt gaaatgttcc aagtccgctt ttcccaaaac tatattctct cttactatac
    44221 ttactcttat tattctctat atagttagag tcaacatttt gaacttcctg aagttcattt
    44281 tctttacttc tgaggttaaa atctcttact tctgaagtta agttttttga cttctgaaag
    44341 tcattttctt ttaccgctat tatgctcata aaatctttaa cataaatgac attcggctta
    44401 ccaagtccaa gccttactct ttcaatcagt cctattcctt ttttgctgtc taactcgtcc
    44461 aatgttttta tggcagtagg ctttgagata tttcttcttc tcataatttc ttcaacagta
    44521 aaatagataa atactctgcc ttccttgtcc acccagttat tcttaaagga cattcctgtg
    44581 cgtttcaaaa gcatggagta tagaataatg gcttcagcag acagtccctt aaattcttct
    44641 ccgtctacta atatttcagg cactttcaga aagttaaatc gctctgcttc tctgttatag
    44701 aaatagtcaa agtccatgca agatcacctc cctccttaaa aatttgcaaa gaaaaagacg
    44761 atagtttttt catctatcgc ctttggtaac catttttatg aaatttttta gattgatttt
    44821 attgcctcat tgataccttg taaaaaagct ataacagttg ccccaaccat cggtattccg
    44881 tatggactaa ctaagaatcc aataatcaat gcttctattc cgatggtaac ttctttttgc
    44941 agaaaagatg caattgctcc aaatatacaa aacatcatca gcaaatatag tagggctgtt
    45001 ccgataccaa gtagaaatgt cagaaatgct gtgaggatac ttaacaccaa gctaattggg
    45061 aataagatta tttttattat ccatctcata atttcttatt cctcactttc aaaaacattc
    45121 tttgtatctc cacacaccat atcaatgcaa acattcacat ccatataatt ttttaagact
    45181 ttttttcgtc ctccctctcc gtcttctaca aatacataat gcttgtaaaa ctgcttaaaa
    45241 tgcagtattt tcactatttc actctttgta tcaacgctat gcactccaca tgatgcgttt
    45301 gaggaaatag atccaccggc tggactttct tcaattcata tcccaattct tggtagagtt
    45361 tgatatcacg cgccatggtt gctacattgc aggagatata ggcgatgcga tcggctcctg
    45421 tttgggcgct tgctttgata aagctttctg tcaagccctt gcgtggagga tcaaccaaga
    45481 taacggttgg ttgaatccca tctttaagcc aattcttcat agcattttca gctgtgtcac
    45541 agacataatg ggcgtttgaa atattgttca gctgagcatt ttttttacta ttctcaaccg
    45601 cttctggaat cagttcaaca ccgtagactt ctttgacatg cttggcgact gataaaccaa
    45661 tggttccaat accagaataa gcatcaataa ccacgtcatc tttttttaac tctgcaaagt
    45721 caatggctgt ttgatagagt ttctccgcca tttcagtatt gacttggtaa aaggctgggc
    45781 cagcgatttg gaagtcattt cccaacatct ggtccgtaat atagtcttga ccataaagag
    45841 tgcgccactc cttaccaaaa atcgcattgg tattctggtc gttgatattt tgcatgacag
    45901 acacaatctc tgggaactgc ttgataactt gttcaatcaa ttggtcaaca cgaaaaactt
    45961 ttggacgagt tgtcaccaaa acgaccatga tttgtcctga atagtgacca cgacgcacca
    46021 caagattccg aatcaatcca gactgttcct tttcgtcata aggttttaaa tcaaaacgac
    46081 ggagcaggtc tcgaagagct actacgactt ggtcaatgac aggatcctgg ataaagaaat
    46141 cttcaagggg catgaggttg tgcgaattct tacggaaaaa tcctgtttcc aagacaccat
    46201 tcactcgacg aacgggcacc tgcgccttat tgcgatactt gactggatgt tccataccaa
    46261 gcgtttcagc aacttctaca tctgcaattc cagcaatctt gtagagactg tccttgactt
    46321 gcttggtttt aaacttgagc tgttctggat aagaaaggtg tcctaaatcc gcgattcctg
    46381 aacgcaggta agccaaatct agatcttgat tacggtgtgg tgactggaca aggtattttt
    46441 caacttttcc aaagccaatc tttttattga ccttgaggac acgcatgaga attttttcac
    46501 tcggtaaagc attctctaca aaaaagacca aaccatctac cttggcaact cctgcccctt
    46561 catgggtcaa atcaacaatt tcaacttcta caatatcatt tttctttaac attcttttct
    46621 ctttctattg gccgacaaaa aagacggcaa cgttacggtt accatccatt ataccatgaa
    46681 atttcttaag aaccaaaact cttgaagaag ttgacaaggg cttgccagag ggagcttaag
    46741 aagttaccac cgtcctctag cgccttatcc gcatcaaagt taaggttgat atttttaaaa
    46801 ctgtcgccag cttgtgatac gatgctttgt ttaaggtcat ttagggtttt agtgaaatct
    46861 gcattgctga ggatatcact ctttgagaga ttcaaggcaa aattgatgat gatattgatc
    46921 tggtttcctg ttatgacctg atcaagtttg taatttttta aggtatcttc aacaatcttg
    46981 cggatatctt cttctgtcag atttcccttg ctttctttag ctttggcgag tcctgacttg
    47041 atatcagcta gggcaacgtt taatttatta gcatcatagc ctgatttgtc cttgttttca
    47101 gcattgatat ctgacaaagt ctttagctct tcttgagcca aatctttatt ggcttgcggc
    47161 accttggctc cattagcttc tagcgaatag tagatcccag ccaaagcact ctcacctgta
    47221 actggaatgg gtgctgctac agtgattttg gcgtgttcca cacccaaagt tacggctgca
    47281 tttcggtaca tatcctgagt taccttagtg atgttttcag gtgtttcaat cttgacctca
    47341 agtggcgatt tgtcacctag cttttgaatc ttggctgatg aatacaactg taagctagag
    47401 tcattggcca cattcatgat tttagaataa acatcaggtg tcatggtctt gagttctttg
    47461 gtatctgttg aggcattgta gcccagtttt ttaagagttt gatttttttg gtcttcagat
    47521 agggaagaac ctaggacata ttcaggttgg acataggttt catcgataac tttttgaaca
    47581 tctgttgctg catagacgct attcatagct gttactgccc acaagatcgc agcgctagtc
    47641 agaaagagtt tctttctcat agggaatttc ctcctttact tctttagagt aatatatcta
    47701 tcttaaagaa aacttataac aaaaacacct ggtctagcca gatgttgaaa agagagtgaa
    47761 acatttgatg atgtaaaggt taagtcgtac ctgtctagaa taataatagt ttcctccatt
    47821 tacatagagt tcagcaccgt gaaaaatgga aatgggatga atataactat aagtctttcc
    47881 agtcgtatta ccaagcaagg gggcaacagt ctcacgagag tactgtttgg ctagagccaa
    47941 ggtattttcc ttgccatttt gggcgataaa atcgatatag gcaggtccaa aattataggc
    48001 ttgaacagct gtccagatat ctacaccctt cttctgcgcc agatagagat tgcctgtcag
    48061 agtttgaatg ccttgccgaa tgctagaggc attatcattg atggtgttgg tggaaccact
    48121 tgcagactca ctagactgca taacatcgcc ttcttttcct tttgtttcag tataaatcat
    48181 agcaagcaca agctcttcgt ttgctggggt gtctttttca ctcaatattt ctcgcaccat
    48241 gggttgatag gtcatgactt gtttgacatc ttgatgaacg cggtaagctt tatagccagc
    48301 aaaaaggaag actgctagta caagcactct tcgaattcgt ttaaacatta tttactttgg
    48361 atatcctcga tatttttgat taagatagag taggttccat tttcgttttg gataaactca
    48421 acagactcgg cgtcttgata gacgttattg ggaacgatga gctcaattcc atttgataag
    48481 gagagttttt ggttttcaaa tttctttaat tggcgactgg catcaatttc atcaaattga
    48541 acaggttctg gtacggcttc tttgacttgg tcaataaagc tcaaacgagc cgtcagattg
    48601 ttgtcaaaaa ggtcattagc caatttctca ggtgacaatt cattgctttc ttctaggttg
    48661 ttgaaaatcg ctgatttgac cttggattga aattgaaaat catctgtgtt aaaagattca
    48721 gcaattctct gggctgtttt ttccagttcc ttgatagatt ttttaggaga aatcttagga
    48781 gcgacagcaa gaagattatc tgaaaaatag ttcaaaaaag tcccgttgta cttgattcgt
    48841 ttttcaatca ggtgatactt gcgactctga agattgacca ccaaggcctc gtcagcaccc
    48901 gttccaaatc caggcaggtt attctgagtc agcttgattg gattatcaac ttctcctccg
    48961 aggtgggtca aggtctcccg cagggcaatt cgcaagaaag cgaaatgttc tacaccttct
    49021 ttagaaaatt gaacaaaaat caagtcattg gtcttgagat tttcagaaat gctaaactcc
    49081 tctttccaga gattagccag cgttactgat gtctccaaca aatcgtctgt aatatgattg
    49141 aagaagggat tttcttcttc gaaaatccca gtcttggctt catctgaata cacatgttca
    49201 atttttttac gtaggtattc ttcgattttt ggagtaatat tgagaaactt atctgctaag
    49261 aacagctcgg tatcatccgg actgaactgg tgaataatgg ctttcttaat ataaatgtcc
    49321 ataaaagttt tattcctcgt ataatgggaa ggcatctgtc aattctttga ctgcacttct
    49381 cacttcttct aatacagcct cattttctga attcttaagg gttttaatga tgagttcagc
    49441 cactttgcga ctttcttctt caccaaattc acgtgcagta atagctgctg ctccgatacg
    49501 aatcccactt gtcttgaatg gtgacaaggt ttcgtaaggg attgaatttt tatttagggt
    49561 aatattgact tcatccagca agttttgagc aacttttccg ttttctacaa ccttagtcac
    49621 atcaacaagg aagagatggt tttcagttcc acctgaaata atacggaaat cagggtcttg
    49681 caagaagaca tctgccatag ccttgctgtt cttaattaca ttggcagcat attccttgaa
    49741 ggctggatcc aaaacttctt tgaaggaaac tgccttagcc gccacaacat gctctaaagg
    49801 accgccctga atacctggga aaatagctga attgattttt ttagcaagtt cttcgtcatt
    49861 ggtcaaaatc aaaccaccac gaggtccacg aagggttttg tgggtcgttg ttgttgtgat
    49921 atgagcgtat ggaactgggc ttggatgaag gccagccgca accaagccag cgatatgggc
    49981 catgtccacc atgagcttcg caccgacagc atctgcgatt tcacggaatt ttgaaaaatc
    50041 gataatttga gaataggctg aagcaccagc tacaatcagt tttggtttta cttcttgggc
    50101 ttgtttcaag atagcatcaa agtctaagag ttccgtttta ggatcaacac tataagaaac
    50161 aaagttgtag gtttgaccag agaagctaac aggagcccca tgagtcaaat gaccacctga
    50221 tgccaaatcc attcccataa ccgtatcacc tggctcaatc aaggacatgt aagccgcaca
    50281 gttagcttgg cttcctgaat gtggttgaac attggcaaat ttagcaccga aaatttcttt
    50341 tgcgcgttca atagcaagag tctctacaac gtctactaca tcagttccac cataataacg
    50401 gcgtcctggg taaccctcgg catatttatt tgtcaagata gacccttgag ctgccataac
    50461 agccttggaa actacgtttt ccgaagcaat taactcgata ttattttgtt ggcgttcttc
    50521 ttctttggca atagcattcc agagatcagc atcatatgct ttaaaatcat ctttgtcaaa
    50581 aatcataggt cttctccttt attgtgtgac tagtccatta gtttgatttt acaataagaa
    50641 aatcaaacta acagatgcga ataaaccgtt tctgcatttt atcacaagta tagccaactt
    50701 tttcataaaa tgcatgagca cccagacgat gattggcaga atttaagcgg ataaacccat
    50761 aaccacatct ttttgcttct tcttccaacc cttgtagtaa acttttacca ataccttgac
    50821 cttgcgcttg aggtgaaact gctaaagcta agatattaaa tcctgctttg gaatagagtg
    50881 attcgtaaac ttcagcgtgg acatatccaa gtaagacatg attagctgca tcctcatagc
    50941 caagtaggaa atgatgggaa tcctgagaca gtctagctag ttggctagcc gtttcctctg
    51001 gactaaaagt ataacccaaa gcctcttggt tgatgtcaca tatcgctttc acatctgttt
    51061 cttgcaaatc tcttagcatt tcaagcctcc tcaaaagaaa tctctggcaa ccgagcaaga
    51121 atatcttctc gtttaattgc gccttggcgt aagattttca ccttgtctcc agacaaatcc
    51181 acaatagttg aatcctgtcc agttagaaaa gcatcgtctt ccagacccag aacctcttgg
    51241 tcaaaatcct tcagaatttg ttcaaaggtt acaccacttg cctgacctga gatattggca
    51301 gacggcccaa tcaagggacc tgtctctcga attaaatcca gtgtgatagg gtgactgggc
    51361 atccgaaatc caatagttgc aaggtcagaa tttacccaat agggaactcg gtcattggct
    51421 tcgagaataa tggtcaaggg acctggcaaa aaggtctcta caagtttttg tagataagct
    51481 ggctgattct ttgaaaagtg caagatgtcc tcgaaagagg cgatattgag attgagtgcc
    51541 ttatctctag gacgacgttt gagttggtaa acatggtcaa ctgctttttc atctaaggcc
    51601 ttggaaaaaa gaccataaac agtctctgta ggtagaacga cagctccacc cttttccaac
    51661 tcttgtctaa tcctgtccat catcaaccac aaccatccta ttttgaccaa attggtcttt
    51721 gagtgttcga actctttttt caggaagatg ttttctaaaa agttcgggaa cacattgacc
    51781 ttgcttgtat ccaatttcaa ggtaaatctt accactatct ttgagatagt ctgttgcatc
    51841 ttccgcaatt ctacggtaaa tagctaggcc atcctcgtct gcaaagagag ctagatgagg
    51901 ctccgaatac aagacattca agcctacctc tgactcatct tcacgagaga tatagggtgg
    51961 attggaaaca attatatcat atttttcaga aatttctgta aaacagtcag atttttttaa
    52021 aaatatttga agattttgat ttttagcatt ttctctagct aaatctaagg cctcttgaga
    52081 aatatctgct gctgtcactg accaatctgg tctatttttt gctagagcga gagcaatagc
    52141 tccactacct gttccaatat ccagaactga gagattcgtc tcaagatttt cagttagaat
    52201 aagctccact aactcctctg tttctggacg aggaatcaaa acccgttcat ccacctttaa
    52261 atgcattcca taaaaatctg cctgtccaat gatgtactga gctggcttgt gagctgctag
    52321 ttgctggtaa atatcttcta caaattgttt ttcttcctct gttgtcacct cctgctggag
    52381 ggcaaaaata aagtctgtaa aagatagatt tttcagacta cgatagacaa aagagaggct
    52441 ttccgcttcc tctccttgtc ttatcaactc ttcttcaaaa tttgaaaata attgagctaa
    52501 tttcattatt tgtttaattc ttctagtttt tgtgtttggt cataaagcac caaggcatcc
    52561 acaacttcgt ccaatttacc agacaaaatc gtatctagtt tttggagggt caagccgata
    52621 cggtggtctg tgacacggtt ttgtgggaag ttataagttc ggatccgttc tgaacggtca
    52681 ccagtaccga ttgtcgactt acgctcagcg tcttgttcat cctgagcaat ctgagcaaag
    52741 tggtcagcga cgcgtgcacg gataatcttc atagccttct cgcggttctt ctgctgggta
    52801 cgttcttcct gcatctcaac cttgatattg gttggcaagt gaacgatacg aacggcagtc
    52861 gcaaccttat tgacgttctg tccaccagca ccagaggcgt gatagatgtc gacacgaagg
    52921 tcttttggat caatgtcgta ttcaacctct tcaacttctg gcataacaag aactgtcgct
    52981 gtcgaagtat gaacacggcc ttggctttct gtcacaggaa cacgttgcac acggtgggca
    53041 cctgattcat acttaagctt agagtataca gactgacctg aaaccatagc aaccacttct
    53101 ttaaaaccac cgacaccatt catagaggct tccatgactt caaagcgcca accttgggct
    53161 tccgcatact tttggtacat agttagcaaa tctccagcga aaagtgccgc ttcgtctcca
    53221 ccagctgctc cacggatttc aaggatgata ttcttgtcat cgtttggatc ctttggaagg
    53281 agcaaaattt tcagtttttc ttcatattct tctttttcag ccttggcatc tttgagttct
    53341 tgcttggcca tttcttccaa gtccgcatct ccgcctgatt ccttaatcat ctcttcggca
    53401 tcgacgatat tttgaaggac ttgtttatac tcacggtagg ctattacggt gtcacgattg
    53461 gaagcttctt cttttgaaag ctccataaaa cgcttggtgt ctgaaacgac atcagggtca
    53521 ctcagcaatt ctcctagttc ttcataacgg tcttctacag cttgtagttg atcatagatg
    53581 ttcatttttt ctccttattt ctcaattgtt aaatcataga ttgctactac ttcattctcg
    53641 gatatttccc cagtttcttt aaatccataa ctgaggtaac aaaatcttgc ctgttcattt
    53701 tctggttcat aagacaacca aagtttattg cttaaacctg ctggcgctgt tcgaacatag
    53761 tctagtactt tatccataat tggtttaaaa tatccttgat tttgaaaatt cttatcaatc
    53821 ataaaacgaa atagtaaata atttccacta ctaattccga tctttttatc ataagctatc
    53881 atcacaaaac ctataattgc atcattatca taaactgcca atgtagctac aaaatctcca
    53941 tttttagtgt agacgtatgc ttcagctaaa ctaattgcgt tggttgcaat gaattgtttt
    54001 tgatattcct tgacatccaa atttaaaaca tcaaaataat tttccattgt aacatctctt
    54061 agttcaattg tcatagtttt gctccttgtt agaggttatc attggcgtaa aataatgttt
    54121 acggcaaact gagatatagg tttcgttacc accaatctgg atctgttctc catcgtaaac
    54181 gggcagtcca tcctgtgttc gcaacaccat ggtcgccttt ttcttgcaat actgacagat
    54241 ggtcttgatt tcgtcaatct tgtctgctaa aagcaagaga tatttggaac cttcgaacaa
    54301 ttcattgcga aagtcatttt tcaagccaaa agccatgacg ggtatgtcta actcgtccac
    54361 aacacgagct aggtcgtaaa catggtggcg tttaagaaac tgggcttcat cgaccaaaac
    54421 acagtaaggt ttttctggta ggtctcggat atagccaaag atatccgttg tttcctcaat
    54481 cgcaagggca gggcgtttca tgccaattcg actcgacaca tagccaacac cgtcacgcgt
    54541 atccagagcc gaggtcataa tgacaacacc ttttccttgc tcctcgtagt tataggccac
    54601 tttgagaatc tcaatcgttt taccagagtt catggtccca taacgatagt acaactgtgc
    54661 catgtttctt gcttcacgtc catttctaaa tttttgctac attctagtat atcataattt
    54721 tcttaagctt taaacggcaa aatgtggtaa aatggaagaa atcaaaacta gtggaggaag
    54781 ctattatgcc atttgtacgc atcgatttat ttgaaggacg cacgctcgag caaaagaaag
    54841 ctcttgctaa ggaagtaacg gaagcagttg tccgcaacac tggagcccct caatctgctg
    54901 tccatgtcat catcaacgac atgccagaag gaacttactt cccacaaggg gaaatgcgta
    54961 ctaaataagc tagcttaagc agaattgctt aggctttttc aatctccaag tagcattcat
    55021 tgaagaaata tcctaaattt gttacaattt gaaaagaaac ttggagaatt tccaagaaaa
    55081 gagctattaa ttaaaggaaa cattatgatt acacgtgaat ttgataccat cgctgctatc
    55141 tctactccac taggtgaagg ggctattggt attgtccgcc tgagcggaac agacagtttt
    55201 gctattgcgc aaaagatttt taaaggaaaa gacttgaaca aggttgccag ccacactctc
    55261 aactacggtc acattattga tcctctgact ggtaaagtca tggacgaggt tatggttggg
    55321 gctatgaagt ctccaaagac cttcactcgt gaggatatta tcgagattaa cacccacggt
    55381 gggattgcgg tgaccaatga aattctccag ctagctattc gtgaaggggc tcggttggca
    55441 gaacctggtg aatttaccaa acgtgctttt ttaaacggtc gcgtagactt gacacaggca
    55501 gaggctgtga tggatatcat ccgtgccaag actgacaagg ccatgaacat tgcggtcaaa
    55561 caattagacg gctccctttc tgacctcatt aacaataccc gtcaagaaat cctcaataca
    55621 cttgcccaag ttgaggtcaa tatcgactat cctgaatatg atgatgttga ggaagctact
    55681 actgccgttg ttcgtgagaa gactatggag tttgagcaat tgctaaccaa tcttcttaga
    55741 acagcccgtc gcggcaaaat ccttcgtgaa ggaatttcaa cagctatcat cggacgtccc
    55801 aacgttggga aatccagcct tctcaacaac ctcttgcgtg aggacaaggc tatcgtaaca
    55861 gatatcgctg ggacaacacg agatgtcatc gaagagtacg tcaacatcaa tggtgtacct
    55921 ctcaaattga ttgatacagc cggtattcgt gaaacagatg acatagtgga acaaatcggt
    55981 gttgagcgtt cgaaaaaagc cctcaaggaa gccgacttgg ttctactagt gctaaatgcc
    56041 agtgaaccac tgactgcgca agacagacaa cttcttgaaa ttagccaaga taccaatcgc
    56101 attattctac ttaataaaac cgacctgcca gaaacgattg aaacttcgaa actacctgaa
    56161 gacgttatcc gtatttcagt ccttaaaaac caaaacatcg acaagattga agagcgaatc
    56221 aacaacctct tctttgaaaa tgctggcttg gtcgagcaag atgctaccta cttgtcaaac
    56281 gcccgtcaca tttccctgat tgaaaaagca gttgaaagcc tacaagccgt taatcaaggt
    56341 cttgagctgg ggatgccagt tgatttgctt caagttgact tgactcgtac ttgggaaatc
    56401 ctcggagaaa tcactgggga tgctgctcca gatgaactta ttacccaact ctttagccaa
    56461 ttctgtttag gaaaataaga aaaatccatg atccttcatt cggtcatgga ttttattgtc
    56521 tttattagta atctggtctt aagacccctg ttacagttgc cttagttgct tcgtagtcgc
    56581 catctacgac aaccttgata atgcgtttgg catcttcttc tggtgctgga acaagaggta
    56641 gacgagtggg tccagcttca aatcccatat agttaagaat tgccttaact ggagcaggac
    56701 ttggataaga gaagagagca ttaaccttag gaatgaattt acgctgaatt gctgcggctt
    56761 tcttcatatc gctttctgca atggcagtaa acatctcgtg catttcatcc ccatttgtat
    56821 gagaggcaac agaaataacc ccatccgccc caaggttcat ggcatggaaa gcatctccat
    56881 cctcacctgt ataaatcaag aactcttcag gcttgtgctc aatcaagtaa gccatattag
    56941 ccaagctagt acattctttg acaccgataa tatttggatg gtcagccaag cgaagcatgg
    57001 tttctggagt caattcgaca actacacgcc ctggaatgtt atagataata attggtaggt
    57061 cagaagcatc tgcaatagtc ttaaagtgct gatacatccc ttcttgagaa ggtttgttgt
    57121 agtaaggaac aatagcaagc ccagctgcga aaccaccaaa ttccgctact tctttgacaa
    57181 actcaataga atcacgcgta tcattagtac ctacacccgc aatcaaagga acgcgtccat
    57241 tgacaacctt ttgtacagcc gcaaacaact ccaactcctc atcgtgggtc aaagttggac
    57301 tctcagcagt cgttcctgcg agaagaattc catccgtatg atgggccaat aaatgctcaa
    57361 tcaaggctgg aatagcatca aagttaatgg aaccatcctc atggaagggg gtaataaagg
    57421 ctgtaatgat tttacattct tttaaatctt gataagacac gaaaacacct ctctatttca
    57481 aagaaggagt tcatctgaac tcctaaacga tatgactatt ttaattcaaa tttcaattcg
    57541 gctgttggac gaaccaatcc acgttcatga agagtttcag caatctgaac tgagttccaa
    57601 gcagcacctt tgagaaggtt atctgaaaca acccacatgt gaattccttt ttctgcatcc
    57661 aagtctttac ggatacgacc aacaaaggta tcacgcgaac caactgcatt gatagcttga
    57721 ggatagattt gatgagctac atcatcttca agaacagcac ctgggaaggc tgcgatagct
    57781 gcttttactt cttcgattgg agccacttct tttgtttcga tataaacaga ctcagagtga
    57841 gctgacaaga ctggaatacg cacacatgtt gcagatactg caatgctatc atcttccata
    57901 attttcttag tttccttggt catcttcatc tcttcgtacg tgtaatcatt atcagtgaaa
    57961 acatcaattt gtggaagagc gttaaaggcg ataggataat gtttcttgtc accacctgaa
    58021 ggcaaaattt ccgcatgcaa atcacatggt ttcacaccat cattcaagac ttcacgaagt
    58081 tcacgttgtg tctcaagaat tgctcccata ccagcacctg aaacggcttg ataagttgaa
    58141 acaatgatac ggtccaagcc ccatttttgg cgaaccggct caagagccac catcatttgg
    58201 attgttgaac aattagggca ggcaatgatt ccgttgtgag catcaagtgc atgagcattg
    58261 acctctggaa caaccaaagg aacatctgga ttttgacgga aataagatgt attatctact
    58321 actaccacgc cagcttttac tgcgtatggt gcatacttag ctgatgtaga actacctgct
    58381 gaaaagagag caatatcaac tccttcaaaa gctgtttcag tcgtttcttc aattgtaata
    58441 tcttgatctt taaatttcaa tgacttacct gctgaacgtg cagaagcaag gtaacggatt
    58501 ttatcgattg gaagtgttga ttcttccaac atttttatca tctgagcacc gacagcacct
    58561 gtcgcgccga ctacagcaac tgtatatccc ataaataacc tctttcggaa ttttctaaaa
    58621 atttctataa tagaagtatt atactacttt ttccatgaat tgcaaagctt tttcatcatt
    58681 ttttggaaaa taaaaatccc agtcgctaga ctagggacta agaggcatct tcatgtgatg
    58741 agcaggttca cacaactcat caaggtccgc tcctgcgtta tgacctcctt atgctcaata
    58801 gtagtccgaa gactacctat cgactcatcg catattctat attactagag atacttgatt
    58861 ttgtcaataa gaaatttttt cgatcgagta taacaaaaaa ctctcgtatt caagagtttc
    58921 cctatacata tcatgctaat tgccgggatt gaaccggcga cctcatcctt accatggatg
    58981 cgctctgcca actgagctaa atcagcttac ttaagaagta tactatattc agaaaaactt
    59041 gtcaagtttc cttagaaatt ttccatagga aaaagccagg taagaactac ctagcttatc
    59101 ttcttctatt tacttaaatc aattcgacga ccaattttac caataataat cgctccaata
    59161 atcaatgaag caaattcacc gattcctgtt gtaaaccaag taaggaagaa tggtaattct
    59221 gctacaatat ttaactctgc agcgatagta aacatggaaa ttgaaaagag gattgaaaag
    59281 aagaaatgat cttttcgaat caatccatta aagaggtaat ccttgctata ttttgcaaaa
    59341 agccaaacac ctaaactgag gaatactaag gttgaaccac caccaacaaa gacatctagc
    59401 agtccgaagc taaagaaatt agcaatcata caaccgatgg taactccgat gatgtactta
    59461 ggattgtaaa aagccataaa gttcatcatt tctgaaatac gaaactgata agcaccatag
    59521 ctgatggcat ttaggggcgg tgtgacagtc aaaacgacgt agatagcagc gacgattgca
    59581 atatctgcaa catcacgaat agttaatttt ttcatctttt ctcctttggc ggttatccgc
    59641 gtgtaatatg cttggtgaaa gaagctaagc accaagggtt gattcattca accttactag
    59701 tatagcacaa tagcctgctt tatgctatac ttaaagcatg aaaaaaccta ttcaaaaatt
    59761 ttttaacaat gaaatcttag cctatctctt ttttggcctt gcgacaactc tagtttcgat
    59821 tctctcacga ctagtcattt atcaactaag tcatcaggaa ctcctggcta ctgccctagc
    59881 aaatattatc ggtatcctat ttgcctttat cacaaatgat acgattgtat ttaagcaaaa
    59941 aaagaaaaat agacttatcc gtttagtgaa attttctctt gctcgccttt ctacttttct
    60001 gttagacttg tttttaactt ttctctttgt aacccaattt cctcacatta tagggcaatt
    60061 cgtaactgaa aacattgata agataaatgc tattgaaaca ataattgcac aaatattcat
    60121 tattatcatc aattatatct tgagcaaggc ctatattttt agaaaataat gctccattta
    60181 tgagcctttt aattgccttc tataatgatt taggatacaa tgaaacacga aacattgaaa
    60241 ggaaaacagt atgttaaaaa atctaaaatc gttcttgctt cgaggaaatg ttattgacct
    60301 tgctgtcggt gttgtcattg cctctgcttt tggtgctatc gttacttcac ttgtaaacga
    60361 cattatcact cctcttattt taaatcccgc tttgaaagct gctaaagttg aacgtatcgc
    60421 tcaactttct tggcatggag tcggctatgg taacttctta agtgctatta tcaattttat
    60481 ctttgtgggt accgccctct tctttattat caagggcatt gaaaaagcac agaaactgac
    60541 tggcataaag aaagaaaaaa ctgccgaaaa aaaaccaacc gaattggaag tccttcaaga
    60601 aataaaagct ctccttgaga aaaaataatc gattaaaagg atctagcgca aagctaaatc
    60661 cttttttctt tactctttgg gtaacttgcc tgctttttca agcatttttt tgataagata
    60721 aggcatctta acattctccc gccctttttt ctcaatcagt tttttcacaa attctggcat
    60781 ttgtaaatct tcagattcag ctaaaatgtt tttcgtctcg tctgaaggaa ctaactcatc
    60841 aaaggtctct tcttctggga gaaattcctt aaactcttga ttttcattga ctctaactgt
    60901 attgaccaaa gcatcaatca aacgagaatc tgtatttggc attggtggac gatggtagtt
    60961 taccccaaat tcctggcata agtcataaca ttctacatca ttgtcaaaca agacctcaat
    61021 atgctcactg atgaaactaa taggtacaaa aatataatgg tctggatgtg ctgtctgttc
    61081 tctgagatac tccaaaacat ctggtttaat ccatggaata ccaatatcac tctcactctg
    61141 ccaagtgttg gtatattgtt ctgaactcaa gcccagtttt tcaacgacta gcttgctatt
    61201 ttcgaaaatt tggtctatat aaggatcacc aaagtccaag gcaaaaatag gcacactatg
    61261 ggctgaaaag atgattttaa agctgtcttg ctttacttct tcttttaaaa tcttagcaat
    61321 ttcatctgcc caatagttta agagcgcttc ttcctgatac cagtccttaa tgaccaaaaa
    61381 ttgaatttgt ttgctttcta aaaatttttc atagcccatg acagagtaga aagaataatg
    61441 gggctccaaa atcaagcaaa tacactgttc aattccgtct gcttccattt gaccgatcac
    61501 atctggaata aagggactgg aaaacttatt agcaaagtag acactgtatt cattccccag
    61561 cctagcttct accaaggcaa cctcttgatg ggtaattttt tgcagaggcg tgcctccaat
    61621 tcgtacataa ttatcataga gagtctgaat ctcgtggtct tggggtctca ccccacgacg
    61681 aatatttgtg aaaaaatcag ctacaccttc aaaggtagtc tcttctggtg aaccgaaggt
    61741 catcattaaa attgcttttt tcatgactgc ttccttgtga tgtttttatc aagtttattt
    61801 tatcattaat tcatcgataa gtaaacgcta acatagggac attctcaatc ttctgtcttt
    61861 tgtttttctc ttctttctat gatacaatgg aaaaaataaa ttcaaaagga gttttttatg
    61921 acttatccaa atctcttgga ccgcttctta acctacgtta aggtcaacac gcgctctgat
    61981 gaacactcta ctactactcc aagtacacag agtcaggttg acttcgcaac aaatgtccta
    62041 attcctgaaa tgaaacgtgt tggactgcaa aatgtttact atctaccgaa tggttttgct
    62101 attggaacct tgccagccaa cgatccgtct ttaacacgta agattggttt tatatcgcac
    62161 atggatactg ctgattttaa tgctgaagga gtcaatccac aggtaattga aaactacgat
    62221 ggtggtgtga ttgaactagg gaattctggt ttcaaactcg atccagctga cttcaagagt
    62281 cttgaaaaat atccaggaca aacgctcatc acaacagatg gaacaagctt gctaggtgct
    62341 gatgacaagt caggaattgc tgaaattatg acagccattg aatatctaac tgctcatcct
    62401 gaaattaagc actgtgagat tcgtgttggt tttggtccag atgaagaaat cggtgttggt
    62461 gccaataaat ttgatgcaga agattttgat gtggattttg cctacactgt tgatggtggt
    62521 ccactaggtg aacttcagta cgagactttc tcagccgctg gtgctgaatt gcatttccaa
    62581 ggtcgtaatg tccaccctgg tactgccaaa gggcagatgg tcaatgccct tcagctagca
    62641 attgattttc ataatcaact tccagaaaat gaccgacctg agttaactga aggttaccaa
    62701 ggtttttacc atctaatgga tgtgacaggt agtgttgagg aggcgcgtgc aagctacatc
    62761 attcgtgatt ttgaaaaaga tgcctttgaa gcgcgtaaag catccatgca atctatcgct
    62821 gataagatga atgaagaact tgggagcgac cgtgtcactc tcaacttgac agaccagtac
    62881 tacaatatga aagaagtcat tgaaaaagat atgactccaa ttaccattgc taaagccgtt
    62941 atggaagatc taggtatcac gcctattatc gaaccaatcc ggggtggaac agacggctct
    63001 aagatttcct ttatgggaat cccaactccg aatatctttg caggtggcga aaatatgcac
    63061 ggacgttttg aatacgttag ccttcagact atggaacgtg cagttgatac catcattggc
    63121 atcgtagctt ataaaggcta aaaagacgag gtagctcagc tacttcgcct ttctttttat
    63181 tctactggtt tttcttgatt tccagtagtt gtagaagatt ctgttgtttc attttctgaa
    63241 gttgattcag caggtttaga atctcttgta ttgcttggtt tgttttcgtc gctagcagtt
    63301 tcaatgttag attctgcagt tgcgtttggt tggttctcag cactggtgtt atcaccattt
    63361 gcttcagcat ttcttgctgg acttgtttct tcacttgcgc tagcttttga ctggatttga
    63421 tgattcaaaa ctagaatagc ttttgtcgat tcaagtaaag ctgttttgtc tttactctta
    63481 gcagaaagtt gatctaataa tgcatccacc ttatcaaagt ccgcatcaga tccattatta
    63541 ctttctaaat aagagtgaag cgacatgaga atatcgtaga gtttttgata gagtacaagt
    63601 gtctgaggat cttgctcagc attttccttt tcttgttgaa gggcgctagc gatacgagtc
    63661 aagacatctt ttacctgact gtttacttca tccaagtctg catcagcctt gtttgtggca
    63721 gcttttagat tttctacttc ttctgccaag gattgtctga ttccttcttc atggatttgt
    63781 tccaagagtt gatttgcctt gctcaaaaga ctttctactt cttccttgct atctgtcgca
    63841 gattattggt tgctatctac catgtactcc taaaacagga gagttataat ccaagattac
    63901 aaggccttac agaaataaga aatccagata agacaatgtt cgtccaagac gctattcgct
    63961 tcgcacagca gcacggattc aatatgcttt aattttaaag tttaggtgtc aagacctctt
    64021 tttagtgtgc ccaaaattta gagaagtaat caatcaacta acttttattt ttttcaaact
    64081 ttcagtaaac tgacctaaag ctaactcaat ctgtctttgt agatgcttct gctatcagct
    64141 agaagttgat ctacttttgc caagactgcc ttctcatcaa aagttccagg ttgatagttg
    64201 gattgcaggg atggaatctt gtttttcaaa gccgcttcat atcccttagt ttgaaccttg
    64261 atgtagtgat tgtggtcgcc atgaggaatc acaaaacctt ctgaatcttc acttataatt
    64321 cgattggcat caaaaccatg accatcttct tcctcatgat ggacatgtag tgacggatta
    64381 cttaatacag aactagaaga acttcctacc tcttccgtgt tagagtgtga tgggggattg
    64441 ttaagagatg acttaggaat atagtgatag tgatccccat gtcttactat ataagcatca
    64501 cctgtatctc tgacaatatc attagggtta aagacatatg tggctgctaa ttcacctgcc
    64561 gacaagtcac tctcaggaat gaaatgatag tgaccaccat gtggtactat agtagattga
    64621 aatagaatat gagcaaattg ataaggggat tttaaagtaa tttctaacaa tgatttagaa
    64681 actatgatgt gctattctaa attcaactca ctatatataa ccatcatcgg tagtataacg
    64741 tccctgtaat tttgctacag atacttctgc actagctcct ttatcgtctt taccatgttc
    64801 ttgtttttgg cgattgattt catcttttgt tcgtacattt tctgcatgag cttgatcttt
    64861 aaggtaaaca taatactttc catctacctt aataatatat cctcccttaa cctaactgac
    64921 gatatcttga tctttcggct gatagttggg ggctttcatt aatagctctt cactaaagag
    64981 cgcatcaaaa ggaactttac cattatagta gtgataatga tcgccatgag aagttacata
    65041 accttgatct gtaatcttaa taacaatttg ttttgcttga attccttctt tttgactaac
    65101 ctagtctgga gtcaaatttt cagtcttctt agtgtcttta ttactgttta catatgaaac
    65161 acgattttta tctgtattgg cctgttagct atgttggttc agagcataaa cacacagact
    65221 taaggaaagg ataacaacag atccagctgc tatatatttc tttttaaatt tcataattac
    65281 ctcatttcta taattattta tatgatgtct tcattattaa atgattaaat aaattaatta
    65341 accaattaat taactagtaa atattccacc tctttttaag ttgtatgtca agaaatttta
    65401 tatattaata ataaaatgaa attctcccaa agtcagagtt ttatttctaa cttttgagag
    65461 aacttcattt ttgattcaga ctttttctac tgctattcct tacgctatga gatcagataa
    65521 attctttttt atcacttctc cacttggcaa tcttaattca atcgttccat ccatattgaa
    65581 tataacacta tctaagccta atccgtaact agctgtaaat ttttctaatt tttcttgtac
    65641 aggatctact gctggagctt cctctaatgc tggatctaac atagggtcac tccccacatt
    65701 cccttctgga ttcaacattc cattatccgt tgagttttct ggttttacag gtttttcgtt
    65761 tggtgcctct ggtaaagaat ctgctggttt attttctgtt ggttggttct caactgttcc
    65821 agtagatact tttccatttt cagatggttt attttcacca tttccttgag gtgcttctcc
    65881 tgtaaaatct gccatattct ttttaatgac ttctcccgat ggtaaatata attcaattgt
    65941 tccgtccata ttaaacaaga cattttctag cttcatccca taactttcag caaattttgc
    66001 tactttttct tgtacaggat ccactgtagg aacttcttct aacgttgaat tactagtact
    66061 attcccagtt tcagaaagtt tttctttttc taccttctca ctagtctttg gttcttctac
    66121 cttttcatca agttttgagt tttcttgtgc tttattcctt ttaaattgtg gtagaatact
    66181 tggtttatca gtttgatttt ctttttccaa gataggtact tccacaatat aagtcgattg
    66241 attgtccaaa taagcatttg ccatgaaggt tacaggaatt ttatttccgg ccgttctggt
    66301 tgttccttgg tttaatttcg gaatcggtaa tttgatttca ccaactttat agttattttc
    66361 taaataagca tttccatgaa attcatcaaa cactctgact aaagcatcag ttcctttagg
    66421 cactgcaaat tgagggttca ctcttaaata agtatcccct gcatggaaag gatagaaaat
    66481 cgtttgactg gccattttgt aagctaaaga ggttggaact gtaaatgtac catcataact
    66541 tacttctgga taatcttttg aagcgatagt atacttaaat gtttgtcctg gtaaataagg
    66601 ttgatctaat tcaaagtttg caatattccc tactccttct ccaaatactt taccagatac
    66661 tttctccaat acttttccat ctggtgttat taattttact agcatattga tacctaattt
    66721 tttctccaat tcaggcggaa aactaaaaga aacgcgtttt tgaccattgg ctagagtaaa
    66781 gttttgatta ttaaacgtac tattttttaa caaattaaca acattcgtta attcttctcc
    66841 agtataaact ttattccctt cttttttagc aactccttct tcgggtttaa acagttcata
    66901 gttactgtga gaatgaccaa ttccaaccgg tttatgttca tcaatcggat ctgcatgatg
    66961 gtgatctcca tgcggataaa taatcgcatt tttttcttta ttcacgacaa tactttcacg
    67021 tttgacacca tattgtttca taatgccagc aattttttct tcgatttttt tatctaaatc
    67081 tttcatttct ttggcattac ttggataatc ctgttcatga gatgacaaag aatctaatcc
    67141 attatgacta gttttaactt cctctaaatg tttttgcgca gccttaattt gctcttctgt
    67201 caagtccttc ttgaagaaat aatgattgtg gtctccgtga ctcatgacaa aacctgattc
    67261 atcttcagcg ataatacgat tagcatcaaa tccgtatcca tcttcttcat gtttctcatg
    67321 tgaagttcct ggattgattg gaagagatgg agaaggtgtt gctagactat tgtttggaag
    67381 agtcggttgc ccaatttgat ttgattttgg aatgtaatgg aaatgatcac catgtcttac
    67441 aatataagct gtagccgttt cttcaacgat atcttttgga ttaaaaatat aaccatcaga
    67501 tgctgaagag agctccttac ttgtcgttaa agaagaagga ttgcttgaaa gactgcctag
    67561 actagacact acttcattag gttttgcatt tgtagaaact gtagaaccag ttccactgat
    67621 aggcaccatt ctagcaatct tttcttctaa ggcagaaagc ttgctgtaag gaataaagtg
    67681 gtaatggtcg ccatgcggaa tcgcaactcc atttggtgta cgactgataa tcttagcagg
    67741 gtcaaagacc aggccatctg attcactgta acgttgggcg ctaggtgaat catagagttc
    67801 cttcaaaaga ctctggagat tttcagattt atttgctggc ttgctagttg atccttttgc
    67861 tacagattgc gtgttattgt cactagctgt tgaagaatag cttaactgac tcggttgcat
    67921 attttttcca gccagatgtg ctttagctgc tgctaattca ctagcagata aatcgctttt
    67981 gggaatgtag tgatagtgac ctccatgagg aacgatataa gcattacccg tatcttcgat
    68041 aatatcagct ggattaaaga cataaccatc atttgtcgta tatcgtccct gagaccttgc
    68101 tacagcaaca ttagagttaa ccttctcatt atctttgaca tgttcttgtt tttgacgatt
    68161 gatttcatct ttagttcgaa cattatcagc atgagctgca tctttcaggt agacataata
    68221 ttttccatcg accttgatga tataaccacc cttgacttca ttgacaatat cagcgtcttt
    68281 aagttgatag tttggatcct tcatcaagag ttcttcacta aagagggcat cataaggaac
    68341 tttcccatta tagtaatgat agtggtcacc gtgtgacgtt acatagccct gatctgtaat
    68401 tttgattaca atttgctcgg cctgaattcc ttctttctgg ctaacctggt ctggtgtcaa
    68461 gttttcactt ttctgacttg actggctgcc atctacataa gagacacgat tattgtcctt
    68521 attttcctgc gaacgatgct ggtttagtgc ataggcacat agactcaagg atacgataac
    68581 agctgatcca gctgctatat attttttact aaatttcata aatccctcat ttcaataaat
    68641 gatgaagttt tttctcaact tcttttactt tattaaatag ttttctaaac cggttattta
    68701 accatttaat taaccagtaa atagtttact atttaaaatt acttttgtca agtttctgtt
    68761 acgtttttct aaaaaagaga agtaacacga aaggttactt ctccatagaa tatgctccat
    68821 tcattttact actgtatagg agccggttga ctttttttta acaaagccaa gagactatct
    68881 acttctgctg aaatagtgtt attatctttc gttccgagaa gaagactact ttttagacca
    68941 gtcaatgtct ccacagcatt ttgtctaata ctagaatctg ttactttttc tagcaaggcc
    69001 tccgcctctg ctatcttagc gttaataaca gaatgctcta cttgaggaat ttcagcctca
    69061 tctgtagtat cttcagcttc ttcctctgta tcttccgtat cagtgcttgg tttataaaga
    69121 ttatctgctg aaggatttaa accagcgtga ttctcttttt catcagattc agggtgagtt
    69181 ggctcactta cttcatcatg ttccttatct tcctcaggtt tttctgtctg aggtttctcc
    69241 tcgtttggtt tttccgtttg attggtatca gcttgaccat ttttgtttct ttgaacatgg
    69301 tcgctagcgt taccaaaacc attatctgaa tgcggacgtt cgtttggatg ttcgacatag
    69361 tacttgacag tcgccaaaag atcctcaaga gtatacccct taggtgcctc ataaaggcct
    69421 tcgtcaaacc actcaaattt gatgttatgg taatgatcat aatgaggtat gattaaacta
    69481 ccgtttttga cttctacagt atattgaaga ttgtaaggca tacgatcaag tggcaccttc
    69541 ttagctgctt tcacgcggtt gtagatagct tctgctcctt ttgcctcagt atttcctgaa
    69601 tcctgatggt
//
LOCUS       DAVHSO010000004        54917 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.004, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000004 DAVHSO010000000
VERSION     DAVHSO010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 54917)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 54917)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..54917
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.004"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(145..2034)
                     /locus_tag="VVR18_000260"
     CDS             complement(145..2034)
                     /locus_tag="VVR18_000260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 domain-containing protein"
                     /protein_id="HEU6031860.1"
                     /translation="MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEF
                     RQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKVQAAKNGAELADVTSEVTEEAD
                     GYTVRVYNPGQEDDIVEVDLVWNLKNLLFLYDDIAELNWQPLTDSSESIEKFEFHVRG
                     DKGAEKLFFHTGKLFRERTVEKSNLDYTIRLDNLPAKRGVELHAYWPRTDFASARDQG
                     LKGNRLEEFNKIEDSIVKEKEQSKQLLTWIFPSILSISLLLSICFYFIYRRKTAPSIK
                     YAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTFDQLIQATLLDVIDRG
                     NVSIISEGDAVGLRLVKEDGLSSFEKDCLNLAFSGKKEETLSNLFADYKVSDSLYRRA
                     KVSDEKRIQARGLQLKSSFEEVLNQMQEGVRKRVSFWGLPDYYRPLTGLEKALQVGMG
                     VLTILPLFIGFGLFLYSLDVHGYLYLPLPILGFLGLVLSVFYYWKLRLDNRDGVLNEA
                     GAEVYYLWTSFENMLREIARLDKAELESIVVWNRLLVYATLFGYADKVSHLMKVHQIQ
                     VENPDINLYVAYGWHSMFYHSSAQMSHYASVANTASTYSVSSGSGSSGGGFSGGGGGG
                     SIGAF"
     gene            2172..3737
                     /locus_tag="VVR18_000261"
     CDS             2172..3737
                     /locus_tag="VVR18_000261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEU6031861.1"
                     /translation="MRKIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQD
                     DDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKEPLVVKTKWEGLVPALTSGKIDMII
                     AGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYLYD
                     LIAQITGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMVQVEPGF
                     KTGEEDTAIAIGLRKNDNRISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSS
                     SFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFRTAPLSENKAIYG
                     LQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYM
                     TEIVRGGILAVDKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTS
                     VLNVISVVELYFSGNTVATQTYQYFQTFTIIAVIYFVLTFTVTRILRFIERRMDMDTY
                     TTGANQMQTEDLK"
     gene            3737..4477
                     /locus_tag="VVR18_000262"
     CDS             3737..4477
                     /locus_tag="VVR18_000262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU6031862.1"
                     /translation="MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGK
                     STFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREKLGMVFQSFNLFENLNVLENT
                     IVAQTTVLKRERTEAEKIAKENLEKVGMGERYWQAKPKQLSGGQKQRVAIARALSMNP
                     DAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGV
                     IAEEGKPEDLFTNPKEDRTKEFLQRYLK"
     gene            complement(4586..4801)
                     /locus_tag="VVR18_000263"
     CDS             complement(4586..4801)
                     /locus_tag="VVR18_000263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031863.1"
                     /translation="MAKSNFEKVESVVGWVRDKKITGYRISKETNAREMSIIALAQGR
                     AKVKNISFETALGLIDFYEKNYEKFED"
     gene            complement(5672..6922)
                     /gene="ilvA"
                     /locus_tag="VVR18_000264"
     CDS             complement(5672..6922)
                     /gene="ilvA"
                     /locus_tag="VVR18_000264"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase IlvA"
                     /protein_id="HEU6031864.1"
                     /translation="MLSSKDIIKAHKVLNGVVVNTPLDYDHYLSEKYGAKIYLKKENA
                     QRVRSFKIRGAYYAISQLSKEERERGVVCASAGNHAQGVAYTCNEMKIPATIFMPITT
                     PQQKIGQVRFFGGDFVTIKLVGDTFDASAKAAQEFTVSENRTFIDPFDDAHVQAGQGT
                     VAYEILEEARKESIDFDAVLVPVGGGGLIAGVSTYIKETSPEIEVIGVEANGARSMKA
                     AFEAGGPVKLKEIDKFADGIAVQKVGQLTYEATRQHIQTLVGVDEGLISETLIDLYSK
                     QGIVAEPAGAASIASLEVLAEYIKGKTICCIISGGNNDINRMPEMEERALIYDGIKHY
                     FVVNFPQRPGALREFVNDILGPNDDITRFEYIKRASKGTGPVLIGIALADKHDYAGLI
                     RRMEGFDPAYINLNGNETLYNMLV"
     gene            complement(6972..7328)
                     /locus_tag="VVR18_000265"
     CDS             complement(6972..7328)
                     /locus_tag="VVR18_000265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEU6031865.1"
                     /translation="MNITNLFSIKTGCDETDRQLQKLFFQLDLQLGELTDQLRKLDSN
                     FVPRSQFVDTLDLNDVEYKEILNYFIFHRNDSEESLVEWLYDWISTNRYELPKEFSIR
                     MAHKYHESVTEVFGDE"
     gene            complement(7566..7802)
                     /locus_tag="VVR18_000266"
     CDS             complement(7566..7802)
                     /locus_tag="VVR18_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031866.1"
                     /translation="MLADQNKADWSYDENAVINIYDDANFEDGRLHMTFEQFFKLAQI
                     AREEGLEIHSPFERAGATKSARYIAKWILRNKKH"
     gene            complement(7909..8931)
                     /gene="ilvC"
                     /locus_tag="VVR18_000267"
     CDS             complement(7909..8931)
                     /gene="ilvC"
                     /locus_tag="VVR18_000267"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEU6031867.1"
                     /translation="MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDV
                     IIGVRPGKSFDKAKEDGFDTYTVAEATKLTDVIMILAPDEIQQELYEAEIAPNLEAGN
                     AVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
                     AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAG
                     YAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMK
                     AVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDD
                     AFKIYN"
     gene            complement(8997..9473)
                     /gene="ilvN"
                     /locus_tag="VVR18_000268"
     CDS             complement(8997..9473)
                     /gene="ilvN"
                     /locus_tag="VVR18_000268"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002927678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase small subunit"
                     /protein_id="HEU6031868.1"
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATEDPNVS
                     RITIIIDVASHDEVEQIIKQLNRQIDVIRIRDITDKPHLEREVILVKMSAPAEKRAEI
                     LAIIQPFRATVVDVAPSSITIQMTGNAEKSEALLRVIRPYGIRNIARTGATGFTRD"
     gene            complement(9466..11166)
                     /locus_tag="VVR18_000269"
     CDS             complement(9466..11166)
                     /locus_tag="VVR18_000269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase large subunit"
                     /protein_id="HEU6031869.1"
                     /translation="MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIY
                     NFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPL
                     LVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRP
                     GPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAG
                     GGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTE
                     ADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQM
                     LLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDV
                     GQHQMWTAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQM
                     TNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAY
                     GIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA
                     "
     gene            complement(11367..13034)
                     /locus_tag="VVR18_000270"
     CDS             complement(11367..13034)
                     /locus_tag="VVR18_000270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HEU6031870.1"
                     /translation="MSKITTSLFQEMVQAASTRLNKQAEYVNSLNVFPVPDGDTGTNM
                     GMTIENGAKEVADKPASTVGEVASILAKGLLMGARGNSGVITSQLFRGFSQAIKDKDE
                     LTGQDLALAFQSGVEVAYKAVMKPVEGTILTVSRGAAIGAKKKAEQTDDTVEVMRAAL
                     EGAKTALAKTPDMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFVATPANM
                     SEMINVEHHKSVAGHVATEDITFGYCTEIMVALKQGPTYAKDFDYDEFRNYLDELGDS
                     LLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVDNMRNQHEAQVEKEATQVIKS
                     AEEKEYALIAVVAGKGLADIFCSQGVDYVIEGGQTMNPSTEDFIKAVEQVNARNIIFL
                     PNNKNIFMAAQSAAEVLEQPAVVVEARTLPQGMTSLLAFDPSKSIEENQERMTAALSD
                     VVSGSVTTAVRDTTIDGLEIHENDNLGMVDGKILVSNPDMHQTLTETLKHMLDEDSEI
                     VTFYVGEDGSEELANEIAQEIVEEFEDVEVEIHQGQQPVYPYLFSVE"
     gene            complement(13037..13402)
                     /locus_tag="VVR18_000271"
     CDS             complement(13037..13402)
                     /locus_tag="VVR18_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEU6031871.1"
                     /translation="MTVKINTKDGQIELTDEVIATVVGGAATEIFGVVGMASKNALKD
                     NFQALLGKENYSKGVVVKAAEDGSIAVDVYTVLSYGTKISEVSKNIQERVAFSLENQL
                     GITAQTVNVYIQNIKVVGE"
     gene            complement(13559..13747)
                     /locus_tag="VVR18_000272"
     CDS             complement(13559..13747)
                     /locus_tag="VVR18_000272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008536053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HEU6031872.1"
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKP
                     KKVWASARALKSGKVERV"
     gene            complement(13863..14039)
                     /locus_tag="VVR18_000273"
     CDS             complement(13863..14039)
                     /locus_tag="VVR18_000273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
                     /protein_id="HEU6031873.1"
                     /translation="MDLDIVVRKSIDELWDLDLTAIPLAAVRDDFYTHNFNSGVLLIN
                     NGMWRAENVTQDLI"
     gene            complement(14150..14348)
                     /locus_tag="VVR18_000274"
                     /pseudo
     CDS             complement(14150..14348)
                     /locus_tag="VVR18_000274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808887.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
     gene            complement(14603..16147)
                     /locus_tag="VVR18_000275"
     CDS             complement(14603..16147)
                     /locus_tag="VVR18_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HEU6031874.1"
                     /translation="MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVK
                     GKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMA
                     VDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILG
                     IASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDD
                     IELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLEIFLKFAPEPHGHKKTDGE
                     IVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNV
                     TQFMAESRENVTNAVSGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVS
                     AKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAE
                     VVMSPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDV
                     ELEEKM"
     gene            16360..16662
                     /gene="gatC"
                     /locus_tag="VVR18_000276"
     CDS             16360..16662
                     /gene="gatC"
                     /locus_tag="VVR18_000276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="HEU6031875.1"
                     /translation="MKITQEEVTHVANLSKLRFSEEETAAFATTLSKIVDMVELLGEV
                     DTTGVAPTTTMADRKTVLRPDVAEEGTDRDRLFKNVPEQDNYYIKVPAILDDGGDA"
     gene            16662..18128
                     /gene="gatA"
                     /locus_tag="VVR18_000277"
     CDS             16662..18128
                     /gene="gatA"
                     /locus_tag="VVR18_000277"
                     /EC_number="6.3.5.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="HEU6031876.1"
                     /translation="MTFNNKTIEELHNLLVSKEISATELTQATLENIKSREEALNSFV
                     TIAEEQALVQAKAIDEAGIDANNVLSGIPLAVKDNISTDGILTTAASKMLYNYEPIFD
                     ATAVANAKTKGMIVVGKTNMDEFAMGGSGETSHYGATKNAWDHSKVPGGSSSGSAAAV
                     ASGQVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGTVSRFGLIAFGSSLDQIGPFAPTV
                     KENALLLNAIASEDTKDSTSAPVRIADFTSKIGQDIKGMKIALPKEYLGEGIDPEVKE
                     TILNAAKHFEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEDA
                     TNLDEIYVNSRSQGFGEEVKRRIMLGTFSLSSGYYDAYYKKAGQVRTLIIQDFEKVFA
                     DYDLILGPTAPSVAYDLDSLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFSQGLPVG
                     LQLIGPKYSEETIYQAAAAFEATTDYHKQQPVIFGGDN"
     gene            18128..19570
                     /gene="gatB"
                     /locus_tag="VVR18_000278"
     CDS             18128..19570
                     /gene="gatB"
                     /locus_tag="VVR18_000278"
                     /EC_number="6.3.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="HEU6031877.1"
                     /translation="MNFETVIGLEVHVELNTNSKIFSPTSAHFGNDQNANTNVIDWSF
                     PGVLPVLNKGVVDAGIKAALALNMDLHKKMHFDRKNYFYPDNPKAYQISQFDEPIGYN
                     GWIEIELEDGTTKKIGIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMR
                     SPEEAYAYLTALKEVIQYAGISDVKMEEGSMRVDANISLRPYGQEKFGTKTELKNLNS
                     FSNVRKGLEYEVQRQAEILRSGGQIRQETRRYDEANKTTILMRVKEGAADYRYFPEPD
                     LPLFEISDEWIEEMRTELPEFPKERRARYVSDLGLSDYDASQLTANKVTSDFFEKAVA
                     LGGDAKQVSNWLQGEVAQFLNAEGKTLEQIELTPENLVEMITIIEDGTISSKIAKKVF
                     VHLAKNGGGAREYVEKAGMVQISDPAILIPIIHQVFADNEAAVADFKSGKRNADKAFT
                     GFLMKATKGQANPQVALKLLAQELAKLKEN"
     gene            19699..20259
                     /gene="efp"
                     /locus_tag="VVR18_000279"
     CDS             19699..20259
                     /gene="efp"
                     /locus_tag="VVR18_000279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HEU6031878.1"
                     /translation="MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRD
                     VRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENE
                     LLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLV
                     VNVPDFIEAGQKLVINTAEGTYVSRA"
     gene            20281..20670
                     /locus_tag="VVR18_000280"
     CDS             20281..20670
                     /locus_tag="VVR18_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEU6031879.1"
                     /translation="MGIEEQLGEIVIAPRVLEKIIAIATAKVEGVHSFSNRSVSDTLS
                     KLSLGRGVYLKNVDEELTADIYLYLEYGVKVPKVAVAIQKAVKDAVRNMADVELAAIN
                     IHVAGIVPDKTPKPELKDLFDEDFLND"
     gene            20663..21085
                     /gene="nusB"
                     /locus_tag="VVR18_000281"
     CDS             20663..21085
                     /gene="nusB"
                     /locus_tag="VVR18_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000203663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HEU6031880.1"
                     /translation="MTSPLLESRRQLRKCAFQALMSLEFGTNVETACRFAYTHDREDT
                     DVQLPAFLIDLVSGVQAKKEELDKQITQHLKVGWTIERLTLVERNLLRLGVFEITSFD
                     TPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ"
     gene            complement(21134..21511)
                     /locus_tag="VVR18_000282"
     CDS             complement(21134..21511)
                     /locus_tag="VVR18_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6031881.1"
                     /translation="MVLSNGQPTFLSTILSFVLLVIIGPVFEETLDRGYLMNTFFPKS
                     KYYLDVILSGLIFGISHLILSHRDPISLLYYSLIGFFFALVYRSTDNLRLTILCHSFF
                     NFLNHAKPIWIFVYNYIYYHFFR"
     gene            complement(21874..22059)
                     /gene="briC"
                     /locus_tag="VVR18_000283"
     CDS             complement(21874..22059)
                     /gene="briC"
                     /locus_tag="VVR18_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biofilm-regulating peptide BriC"
                     /protein_id="HEU6031882.1"
                     /translation="MTGTNTFTVLSTEDLEQTSGGLAVWEDGYSRWLYYREFAPYMRQ
                     GALNSYIDAWKYGFRAG"
     gene            complement(22218..22985)
                     /locus_tag="VVR18_000284"
     CDS             complement(22218..22985)
                     /locus_tag="VVR18_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyl transferase
                     subunit alpha"
                     /protein_id="HEU6031883.1"
                     /translation="MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAV
                     VGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVT
                     FINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRV
                     WMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSS
                     KELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY"
     gene            complement(22982..23848)
                     /locus_tag="VVR18_000285"
     CDS             complement(22982..23848)
                     /locus_tag="VVR18_000285"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001173351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HEU6031884.1"
                     /translation="MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTI
                     YQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLA
                     SMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKL
                     PVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAM
                     EGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTI
                     ASLVRLHGGSPR"
     gene            complement(23885..25252)
                     /gene="accC"
                     /locus_tag="VVR18_000286"
     CDS             complement(23885..25252)
                     /gene="accC"
                     /locus_tag="VVR18_000286"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000488661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HEU6031885.1"
                     /translation="MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLL
                     ADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKF
                     IGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
                     AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEH
                     GHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEF
                     LLDEASSNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGH
                     AIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKII
                     VHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPK
                     YQEKE"
     gene            complement(25264..25686)
                     /gene="fabZ"
                     /locus_tag="VVR18_000287"
     CDS             complement(25264..25686)
                     /gene="fabZ"
                     /locus_tag="VVR18_000287"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HEU6031886.1"
                     /translation="MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFF
                     NGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQL
                     VMTATFVKRRGTIAVVEAKAEVDGKLAASGTLTFAIGN"
     gene            complement(25683..26168)
                     /locus_tag="VVR18_000288"
     CDS             complement(25683..26168)
                     /locus_tag="VVR18_000288"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001052236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HEU6031887.1"
                     /translation="MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVA
                     TQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVASEGNLVESPLVGVVYLAAGP
                     DKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRI
                     K"
     gene            complement(26171..27406)
                     /gene="fabF"
                     /locus_tag="VVR18_000289"
     CDS             complement(26171..27406)
                     /gene="fabF"
                     /locus_tag="VVR18_000289"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HEU6031888.1"
                     /translation="MKLNRVVVTGYGVTSPIGNTPEEFWNSLATGEIGIGGITKFDHS
                     DFDVHNAAEIQDFPFDKYFVKKDTNRFDNYSLYALYAAQEAVNHANLDVEALNRDRFG
                     VIVASGIGGIKEIEDQVLRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSI
                     NTACSSSNDAIGDAFRSIKFGFQDVMLVGGTEASITPFAIAGFQALTALSTTEDPTRA
                     SIPFDKDRNGFVMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEG
                     QGAIKAIKLALEEAEISPEQVAYVNAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSF
                     TGHLLGAAGAVEAIVTIEAMRHNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISN
                     TFGFGGHNAVLAFKRWENR"
     gene            complement(27428..28159)
                     /gene="fabG"
                     /locus_tag="VVR18_000290"
     CDS             complement(27428..28159)
                     /gene="fabG"
                     /locus_tag="VVR18_000290"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HEU6031889.1"
                     /translation="MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEEL
                     LAEFSNYGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKMTE
                     ADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQANYAASKAGL
                     IGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKEATLAQIPMKEFGQAEQVA
                     DLTVFLAGQDYLTGQVVAIDGGLSM"
     gene            complement(28193..29113)
                     /gene="fabD"
                     /locus_tag="VVR18_000291"
     CDS             complement(28193..29113)
                     /gene="fabD"
                     /locus_tag="VVR18_000291"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HEU6031890.1"
                     /translation="MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDL
                     RYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGA
                     LDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
                     TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTALLEPASQKLAETLAQVS
                     FSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGK
                     VLSGFVKKIDQTAHLAHVEDQASLVALLEK"
     gene            complement(29106..30080)
                     /gene="fabK"
                     /locus_tag="VVR18_000292"
     CDS             complement(29106..30080)
                     /gene="fabK"
                     /locus_tag="VVR18_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HEU6031891.1"
                     /translation="MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGG
                     NAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKY
                     MERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATA
                     ISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDT
                     TISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVD
                     GGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWAGVVRND"
     gene            complement(30199..30423)
                     /locus_tag="VVR18_000293"
     CDS             complement(30199..30423)
                     /locus_tag="VVR18_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEU6031892.1"
                     /translation="MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISE
                     IEDAFDIQIEAENDLKTVGDLVAYVEEQAK"
     gene            complement(30483..31457)
                     /locus_tag="VVR18_000294"
     CDS             complement(30483..31457)
                     /locus_tag="VVR18_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HEU6031893.1"
                     /translation="MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRH
                     ISRTESTSDLATEVAKKLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGANK
                     AFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
                     AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVF
                     DFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMME
                     YGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI"
     gene            complement(31457..31891)
                     /locus_tag="VVR18_000295"
     CDS             complement(31457..31891)
                     /locus_tag="VVR18_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEU6031894.1"
                     /translation="MDYQRINEYLTSIFNNVLVIEEVNLRGSRFKDISIKEMHTIDVI
                     GKAPDVTPSQVSKELMVTLGTVTTSLNNLERKGYIERVRSEQDRRVVHLHLTKKGRLI
                     HRLHKRFHKAMVEKIIDGMSEEEIAVMGKGLTNLYQFLEDLK"
     gene            complement(31985..32770)
                     /locus_tag="VVR18_000296"
     CDS             complement(31985..32770)
                     /locus_tag="VVR18_000296"
                     /EC_number="4.2.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase"
                     /protein_id="HEU6031895.1"
                     /translation="MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEEN
                     PAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVL
                     MEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAA
                     QLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWES
                     QFKDWQGYATLELNLQKSLAQTEDFKEGVRAHSERRRPKFTGK"
     gene            33139..34503
                     /locus_tag="VVR18_000297"
     CDS             33139..34503
                     /locus_tag="VVR18_000297"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HEU6031896.1"
                     /translation="MKVVKFGGSSLASASQLEKVLNIVKSDSERRFVVVSAPGKRNAE
                     DTKVTDALIKYYRDYVAGNDISKSQSWIIDRYAAMVSELGLKPAVLEKISKSIHALAT
                     LPIEENEFLYDTFLAAGENNNAKLIAAYFNQNGIDARYMHPREAGIVVTSEPGHARII
                     PSSYDKIEELTNTNEVLVIPGFFGVTKENQICTFSRGGSDITGSIIAAGVKADLYENF
                     TDVDGIFAAHPGIIHQPHSIPELTYREMRELAYAGFSVLHDEALLPAYRGKIPLVIKN
                     TNNPDHPGTRIVLKHSNDEFPVVGIAGDSGFVSINMSKYLMNREVGFGRKVLQILEEL
                     NIGWEHMPTGIDDLSIILRSRQLTPIKKEEILRQLVQKAKVDHAEIEHDLSIIMIVGE
                     KMKSHIGVTATATRALSENKINIQMMSQGSSEVSIMFVVNKDQEKAAIKALYNAFFGE
                     SKED"
     gene            34506..34877
                     /locus_tag="VVR18_000298"
     CDS             34506..34877
                     /locus_tag="VVR18_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HEU6031897.1"
                     /translation="MAQSLNKTVLLSTTGTSYLSIAGKVGKFLVGDQALEFYPDVNVE
                     QFIQIPWSHINQIGANVTGRKISRHFEVFTDKGKFLFASKDSGAILKIARKKLGNDKV
                     VKLPTLIQTISQKFKNLFAKK"
     gene            35091..36365
                     /gene="serS"
                     /locus_tag="VVR18_000299"
     CDS             35091..36365
                     /gene="serS"
                     /locus_tag="VVR18_000299"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HEU6031898.1"
                     /translation="MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVK
                     VETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTT
                     TLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
                     ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTF
                     ELSDTNFVLIPTAEVPLANYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIR
                     LHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSAAKTY
                     DLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTV
                     AAILENYQNEDGSVTIPEALRPYMGGAEVIKP"
     gene            complement(36390..37289)
                     /locus_tag="VVR18_000300"
     CDS             complement(36390..37289)
                     /locus_tag="VVR18_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000735961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HEU6031899.1"
                     /translation="MKKLPLVFSGCLLGLAGAGNLILDTLPVLSHLFSLTGLVLWIYF
                     LILHLFNWKETKQELTKPPLLSGMATFPMAGMILSTYVFRVFSYLPLVAQGIWWFSFL
                     LDLTLIAGFTIKFACPGRRVHATPSWTVLYVGIAVAALTYPLVGIIEIAYATLSFGFL
                     LTFYLYPLIYSDLKKYPLPLALLGQEGIYCAPFSLLLASLVRVGGTSLPTWVLIVMIL
                     ASQSFFFFVLTRLPNILKQGFQPAFSALTFPTIITATSLKMAQGILKLPFLDYLVLAE
                     TVICLTILFFVLGAYLIWLRKKV"
     gene            complement(37398..37946)
                     /locus_tag="VVR18_000301"
     CDS             complement(37398..37946)
                     /locus_tag="VVR18_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000206764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HEU6031900.1"
                     /translation="MTTFTIHTVESAPAEVKEILETVEKDNNGYIPNLIGLLANAPTV
                     LEAYQIVSSIHRRNSLTPVEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMNDDLIQA
                     LRNRTPIETDPKLDTLAKFTLAVINTKGRVGDEALSEFLEAGYTQQNALDVVFGVSLA
                     ILCNYANNLANTPINPELQPYA"
     gene            complement(38164..39486)
                     /locus_tag="VVR18_000302"
     CDS             complement(38164..39486)
                     /locus_tag="VVR18_000302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HEU6031901.1"
                     /translation="MLELLKSIDAFAWGPPLLILLVGTGIYLTMRLGLLQVLRLPKAF
                     QLIFIQDKGHGDVSSFAALCTALASTVGTGNIIGVATAIKVGGPGALFWMWMAAFFGM
                     ATKYAEGLLAIKYRTKDDHGAVAGGPMHYILLGMGEKWRPLAVLFAVAGVLVALLGIG
                     TFTQVNSITESIQNTTTISPAITALVLSVFVAIAVFGGLKSISKVSTTVVPFMALIYI
                     LGTLTVIFFNIGKIPGTIALVFTSAFSPLAAVGGFAGASVRMAIQNGVARGVFSNESG
                     LGSAPIAAAAAKTNEPVEQGLISMTGTFIDTLIICTLTGLTILVTGVWSGDLNGVALT
                     QSAFSTVFSHFGPALLTIFLVLFTFTTILGWNYYGERCFEFLFGARFIWLYRVFFVLM
                     VLLGGFIELDMVWIIADIVNALMALPNLIALLVLSPVVIAETKKYFDK"
     regulatory      complement(39577..39665)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            complement(39829..42165)
                     /locus_tag="VVR18_000303"
     CDS             complement(39829..42165)
                     /locus_tag="VVR18_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HEU6031902.1"
                     /translation="MNKKILETLEFDKIKALFEPHLLTEQGLEQLRQLAPTAKADKIK
                     QAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSREL
                     QSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
                     SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTV
                     YIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRA
                     KVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGK
                     TIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNI
                     VDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYG
                     IETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQD
                     NDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRVLKKLYNELNREKETELNKARE
                     QAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAK
                     KKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPV
                     KKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTG
                     VIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG"
     gene            complement(42269..42817)
                     /locus_tag="VVR18_000304"
     CDS             complement(42269..42817)
                     /locus_tag="VVR18_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CvpA family protein"
                     /protein_id="HEU6031903.1"
                     /translation="MISFLLLLVLVWGFYIGYRRGLLLQVYYLISAMASAFMAGQFYK
                     GLGEQFHLLLPYANSQEGQGTFFFPSDQLFQLDKVFYAGIGYLLVFGIVYSIGRLLGL
                     LLHLIPSKKLGGKLFQVSAGILSMLVTLFVLQMALTILATIPMAVIQNPLEKSIVAKH
                     IIQSIPITTSWLKQIWVTNLIG"
     gene            complement(42814..43116)
                     /gene="zapA"
                     /locus_tag="VVR18_000305"
     CDS             complement(42814..43116)
                     /gene="zapA"
                     /locus_tag="VVR18_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HEU6031904.1"
                     /translation="MANLNRFKFTFGKKSLTLTSEHDNLFMEEIAKVATEKYQAIKEQ
                     MPSADDETIALLLAVNCLSTQLSREIEFDDKEQELEELRHKLVTCKQEQSKIEDSL"
     gene            43203..44084
                     /locus_tag="VVR18_000306"
     CDS             43203..44084
                     /locus_tag="VVR18_000306"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HIII"
                     /protein_id="HEU6031905.1"
                     /translation="MASITLTPSEKDIQAFLEHYQTSLAPSKNPYIRYFLKLPQATVS
                     IYTSGKILLQGEGAEKYASFFGYQAVEQTSGQNLPLIGTDEVGNGSYFGGLAVVATFV
                     TPDQHDFLRKLGVGDSKTLTDQKIRQITPILKEKIQHQALLLSPSKYNEVIGDRYNAV
                     SVKVALHNQAIYLLLQKGVQPEKIVIDAFTSAKNYDKYLAQEANRFSNPISLEEKAEG
                     KYLSVAVSSVIARDLFLENLENLGRELGYQLPSGAGTASDKVASQILQAYGMQGLSFC
                     AKLHFKNTEKAKKRLER"
     gene            44088..44702
                     /gene="lepB"
                     /locus_tag="VVR18_000307"
     CDS             44088..44702
                     /gene="lepB"
                     /locus_tag="VVR18_000307"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HEU6031906.1"
                     /translation="MNSFKNFLKEWGLFLLILSLLALSRIFFWSNVRVEGHSMDPTLA
                     DGEILFVVKHLPIDRFDIVVAHEEDGNKDIVKRVIGMPGDTIRYENDKLYINDKETDE
                     PYLADYIKRFKDDKLQSTYSGKGFEGNKGTFFRSIAQKAQAFTVDVNYNTNFSFTVPE
                     GEYLLLGDDRLVSSDSRHVGTFKAKDITGEAKFRFWPITRIGTF"
     gene            44830..47196
                     /locus_tag="VVR18_000308"
     CDS             44830..47196
                     /locus_tag="VVR18_000308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HEU6031907.1"
                     /translation="MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVT
                     GTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLK
                     TAQKIVDTYGENTIDEILQHPEKLEGIAGLSAKNREAFVSTLRLNYGTEMVLAKLANY
                     GIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERF
                     RAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDK
                     VQQIDTKIFDNSLFFAEEGIRSHLIRILEKGKQKSQDLETIQKHITTVEQELGIEYDN
                     IQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDLRKKSNLPILLAAPT
                     GRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDADFIIVDEFSMVDTWLANQL
                     FSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSKESTIVTLA
                     SQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGAALRNGIPARDIQVLAPMYR
                     GTAGIDAINQLMQDLLNPPQKDQLSFEVPQCHYRKRDKVIHLVNDAEINVFNGDLGAI
                     TDLIPGKYTESKQDEIVIDFDGNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPI
                     TSASRRMLERNLIYTAITRAKSKLILLGELQAFDYATQHIGTARKTYLIERFSDLLEN
                     VEEKQQAVSETVTSSASEQSYILTEENWDSIPAMIGITDTDLKEIFGK"
     gene            complement(47244..48527)
                     /locus_tag="VVR18_000309"
     CDS             complement(47244..48527)
                     /locus_tag="VVR18_000309"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HEU6031908.1"
                     /translation="MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGF
                     RKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQ
                     DWVITAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAA
                     ENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVT
                     FPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKEL
                     ATAKEEAYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDM
                     YFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYN
                     MEVAQVQNLLSADMLKHDITIKKAVELITSTATVK"
     gene            complement(49335..50471)
                     /locus_tag="VVR18_000310"
     CDS             complement(49335..50471)
                     /locus_tag="VVR18_000310"
                     /EC_number="1.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HEU6031909.1"
                     /translation="MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEK
                     GKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAIQRTDIITTAIGPNILPFIAELL
                     AKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
                     DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVN
                     SGHATSAYIGAHYGAKTILEALQNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHK
                     VIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSLSYKNLLKTVGYAFD
                     YRDVNDEESIRLGELLAKQSVKDVVIQVTGLDDQELIDQIVEYI"
     gene            complement(50533..50970)
                     /locus_tag="VVR18_000311"
     CDS             complement(50533..50970)
                     /locus_tag="VVR18_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6031910.1"
                     /translation="MKLEKHLIKLNKQFSNKEEAICYCGQVLYEGGYVNEDYIEAMIE
                     RDKELSVYMGNFIAIPHGTDAAKKDVLKSGITVVQVPRGVDFGNVSNPQVATVLFGIA
                     GIGNEHLEIIQKISVFCADVDNVLKLADAQSKEEVLRLFDAVE"
     gene            complement(50972..52927)
                     /locus_tag="VVR18_000312"
     CDS             complement(50972..52927)
                     /locus_tag="VVR18_000312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEU6031911.1"
                     /translation="MLLTKREEQLLKAFLHVGKLSMQDMTEILQVSSRTIYRTLSDLT
                     DSMEQYGIEITKHGKYYILTGELDDLPTELEVLVEYSPQERQELITYRLLTESGFVTN
                     EALQECTKVSNVTIIQDISDIDKRLLDFDLKIERQKGYRISGDSVGKRRFLAILLTNC
                     ISVADFSTGNFGSFDILEADRTRLASQIVNKQLSGFPDMDARMKMFFAILLSLIGQEQ
                     NIENSPNTSKQALEISQKIFQAYSKQTAQFYSIQEIIYFASILDELIIKRQDNPLFTE
                     KFDGEFFYNISNLIDTVSMYIKIDFFKDKVLFNFLFHHIRLSLGVPILFQGENLPESV
                     QILVERNKFLYTVISLLVNDIFPKYLHTEYEYGMIALHFISSLGRSPEIYPVRVLLLT
                     DERRVTRDLLVSKIKSVAPFVELIDIQSLVDYHSIDLSQYDYILSTKPLTNQEIDVIS
                     SFPTVKELLELQERLQYVQAHRTIVARDAIAPEKSYDLQDYLISSSQLLSQFELVQLE
                     NNQSFEHTVEQIIQYQKNVSDRDYLTRKLLSHFQNSPMAIPNTGLVLLHSQSSKVTTN
                     SFTMFELKLPISALSMKREEEEVKRCLLMLMSKEASEEARDLMTAISQSIIENHLYTE
                     IYKTGNQSIIYQMLNTIFNEKIKKLEN"
     gene            complement(52951..54720)
                     /locus_tag="VVR18_000313"
     CDS             complement(52951..54720)
                     /locus_tag="VVR18_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannitol transporter subunit IICBA"
                     /protein_id="HEU6031912.1"
                     /translation="MEEKVSLKVRVQKLGTSLSNMVMPNIGVFIACGVLTALFIADGY
                     LPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGAVVGSIATVGAITGSSVPMFIGA
                     MVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSADLVGFALLLLAFYAIGPVVSTLT
                     GAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFL
                     LEANPGPGLGILLAYAVFGKGSAKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAM
                     AGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHINVLLGVLVAAVVSFLVA
                     ALILHADKSTEDSLEAAQAATQAAKAQSKGQLVSTSVDAVVSTDSVEKIIFACDAGMG
                     SSAMGASILRDKVKKAGLEIPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHV
                     SVDNFLASPRYDEIVASLTGASPIAEIEGDIPTSAPVDSQQIDLNPIDAVVVAYGKAQ
                     GTATMGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQQAAPNS
                     QFLIVDSLVTTPEYDKMAARMYK"
BASE COUNT        16275 a        12441 c        10198 g        16003 t
ORIGIN      
        1 ggctttttgc cgtgctctaa aatcatcgcc aaatcatcaa attgaaataa gaaatagttt
       61 agataaaact attgactttt cttatagttt gtctttcttc tatcttccat tatatcatac
      121 tttttcagtc tatggtagct ctctttaaaa ggctccgata ctgccgccac ctccgcctcc
      181 agagaagcca ccgccagaac ttccacttcc agaagatacg gagtaggtac ttgctgtatt
      241 tgcgacacta gcataatggc tcatttgcgc gcttgaatga taaaacatac tgtgccagcc
      301 ataagctaca tatagattga tatctggatt ttcaacttga atctgatgaa ccttcatcaa
      361 atgactaacc ttgtccgcat agccaaataa ggttgcatag accaagagac gattccaaac
      421 aacaatactt tccaattcag ccttatccag tcgtgcaatc tcacgcaaca tattttcaaa
      481 actggtccag agatagtaga cctcagctcc cgcttcattt agaacaccat cacgattatc
      541 tagtcgaagc ttccaataat agaaaacaga caaaactaac cctagaaaac caagtattgg
      601 caaagggagg taaagatagc catgaacgtc taaactgtac aagaacaaac caaatccgat
      661 aaataggggc aagatagtca agacacccat acccacttgc aaagcctttt ccaaaccagt
      721 taaaggacga tagtaatctg ggagccccca gaaggaaact cgttttctca ctccttcttg
      781 catctggttc aatacctctt caaaagaaga tttgagttga agccctcttg cttgaatccg
      841 tttttcatca gaaactttgg ctctacgata aagactatca gataccttgt aatccgcaaa
      901 caaattggaa agagtttctt cttttttacc tgaaaaagct agatttaggc agtctttctc
      961 aaagcttgac aaaccatctt cttttactag cctcaaacca actgcatctc cttctgaaat
     1021 gatagagaca ttcccacggt ctatcacatc tagcaaggta gcttgaataa gttgatcaaa
     1081 ggtgaatttt ccagctccct tgaccaaggg actcacttcc tccaaggagg tcgagtagac
     1141 tgcttctgat aaaaccatag gctctaattc cattgggggt tcatagagac gatgattttt
     1201 agcatatttg attgaaggag cggtctttct tctatagata aaatagaaac agatgctcaa
     1261 taacaaggag atggaaagga tcgaagggaa gatccaagta agtagttgtt tactttgctc
     1321 tttttcttta acgatcgaat cctctatctt attaaactct tctaaacgat tccctttcaa
     1381 gccctgatcc ctagcgctag caaaatcagt tcgcggccag taggcatgca attcaactcc
     1441 acgcttagcc ggaagattgt ctaaacgaat agtataatca aggttactct tttcaaccgt
     1501 tctctctcta aaaagtttcc ctgtatggaa aaagagtttc tcagccccct tgtctcccct
     1561 tacatgaaat tcaaactttt caatagactc tgaactatct gtcagaggtt gccaatttaa
     1621 ttcagcgata tcatcataaa ggaaaagtaa attttttaag ttccagacga ggtcaacttc
     1681 aactatgtcg tcctcctgac ctggattata gactctcaca gtataaccat ccgcttcttc
     1741 tgttacttcg ctagtcacat ctgctagttc tgcaccgttt ttcgcggcct gaacctttgg
     1801 atgagggtca atgtcaaacc cgctaggcat cttaccagca cgtccaagtc ccacgatttg
     1861 gcccttaaag tcctcctcaa actggtaaac tatcttctgt ctaaactctg ccgtattatc
     1921 tgcatgaata tacaaatccc cttgataaga gtttatcttg aaatcaatgg caaaaacaga
     1981 gagtggaaga aggcaaaaca agcctaacac cagtaagaaa aaagtttttt tcatcaacta
     2041 agcccccttt ttatctttct tatcattata gcattttttc gtaagtaaag gcttacttat
     2101 gttgaaaaat tacgcatttt tcgataaaat aggagacagt tattttttaa tagatcagaa
     2161 taggagaaat catgagaaaa atatacttat ctattttcac aagtctcttg ctgatgctag
     2221 gacttgtcaa tgttgctcaa gccgatgaat atttacgcat cgggatggaa gcagcatatg
     2281 ctccctttaa ctggacccag gatgatgata gcaacggagc tgtcaaaatc gatgggacca
     2341 atcagtatgc caacggatac gatgttcaaa tcgccaagaa aatcgctaag gacttaggta
     2401 aagaaccttt ggttgttaaa accaagtggg aaggtctagt ccctgccctt acttctggta
     2461 agattgacat gattatcgca ggtatgagtc caactgcaga acgcaaacaa gaaattgcct
     2521 tttcgagcag ttactacact agcgaaccag ttctactggt caaaaaagat tctgcctatg
     2581 caagtgctaa atctttggat gactttaatg gtgcgaaaat cacttctcaa caaggtgtct
     2641 acctttatga cttgattgca caaatcacag gtgctaaaaa agaaacagcc atgggagact
     2701 tcgctcaaat gcgccaagct cttgaggctg gtgtcatcga cgcctatgtt tctgaacgcc
     2761 cagaagctct gactgccgaa gccgctaact ctaagttcaa gatggtccaa gtagaaccag
     2821 gtttcaaaac tggggaagaa gatacagcta tcgctatcgg gcttcgtaaa aatgacaatc
     2881 gtattagcca aatcaatgcc agcattgaaa ccatttcaaa agatgaccaa gttgccttga
     2941 tggatcgtat gatcaaggaa caacctgccg aagctacaac aactgaagag actagcagta
     3001 gtttctttag ccaagtcgct aaaattcttt ctgaaaactg gcaacaactc ttgcgtggtg
     3061 ctggtatcac tcttttaatc tctatcgtcg gaaccatcat aggtctcatt attggacttg
     3121 ccattggtgt cttccgtact gctcctctct ctgaaaacaa agccatttat ggccttcaaa
     3181 aactagtcgg ctgggttctc aatgtctaca ttgaaatttt ccgtggtacg ccaatgattg
     3241 ttcaatcgat ggttatctac tatggaactg cccaagcttt cgggatcaac cttgaccgta
     3301 cactggctgc tatcttcatc gtttcaatca ataccggtgc ctacatgact gaaatcgtcc
     3361 gtggtggtat cctagcagtt gacaagggac aatttgaagc tgcgactgct cttggtatga
     3421 cccataacca gaccatgcgt aagattgtcc tacctcaggt agtccgtaac atcctacctg
     3481 caactggtaa tgaatttgtc atcaatatca aagatacatc tgtattgaac gttatctctg
     3541 ttgtcgaact ttatttctca ggaaataccg tggcaacaca aacctatcaa tacttccaga
     3601 catttacaat catcgccgtg atttactttg tcctcacctt caccgtaaca cgtatcctac
     3661 gctttatcga gcgcagaatg gacatggata cctacactac aggtgctaac caaatgcaaa
     3721 cggaggattt gaaataatga cacaagcaat ccttgaaatt aaacacctca aaaaatccta
     3781 tggacaaaac gaagtgctaa aagacatttc tctcactgtc cacaagggag aagttatttc
     3841 tatcatcgga agctctggaa gtgggaaatc aaccttccta cgctccatta acctacttga
     3901 aacgccaact gatggacaaa tcctttatca tggacaaaac gtcctcgaaa aaggctatga
     3961 cctcacgcaa taccgtgaaa agttagggat ggttttccaa tcctttaacc tctttgaaaa
     4021 tctcaacgtt cttgaaaaca caatcgtcgc tcagacaact gtcctaaaac gcgaacgcac
     4081 agaagctgaa aagattgcca aagaaaacct ggaaaaggtc ggcatgggag aacgctactg
     4141 gcaagccaaa ccaaaacaac tctcaggtgg tcaaaaacaa cgtgtggcca tcgctcgtgc
     4201 cctctccatg aatccggacg ctattctctt tgatgaacca acatcagctc tcgatccaga
     4261 aatggttgga gaagtcctca aaatcatgca ggacctggct caggaaggct tgaccatgat
     4321 tgtcgtaacc catgaaatgg aatttgcccg tgatgtctct caccgtgtta tctttatgga
     4381 taagggcgtg atcgctgaag aaggtaaacc agaagacctc ttcaccaatc ctaaagaaga
     4441 ccgaacaaaa gagttccttc aacgctatct caaataaaaa gaaaaggctg catcaaccgt
     4501 gcagtctttt tgctgtcctc aaaatgaaaa ggcagattct ctatctctac tacttgaagg
     4561 tcaagaatcc gccgttatcc aaagattaat cttcaaattt ttcataattt ttttcataga
     4621 aatcaattag gcctagggct gtttcaaatg aaatattttt tacttttgca cgaccctgcg
     4681 ccagagcaat gatagacatt tcacgcgcat tcgtttcttt agagatacgg tagcctgtga
     4741 ttttcttatc acgaacccag ccaacaactg attctacttt ttcaaagttt gacttagcca
     4801 tgtttttctc ctattttctt ctttataata tttaattgta tacgttttta ctacttttgt
     4861 caataaaaaa aaacatatat tcaacgagaa taattagttc agaattttct tacttccttt
     4921 ttaaatccga taatatatag gttttgctag cctctacacc ataaatattt gctaataaaa
     4981 atactgtatt attaccctct taaggtgcga aattattcaa gttcttaaaa atgcttctct
     5041 atttccgtaa gatagcttat ttcttcgatt taagaactga agatgatagt tctaaccttt
     5101 agaaatccaa gccttcacta gctcaaaaac tcctatcttt cttcctcaat aaatcatctg
     5161 agagataggt attccttata tccttcaaat tcatcactcc tttggatatt gaggtgctag
     5221 cctagaagca gacacccgat tatctaaacc atccttaata aagatgacaa gacagataag
     5281 ctcagttaat tacttatata tccttttaat atggtatatt tgtcaacaaa aagaaatcaa
     5341 atcatacctt atactcaatg aaaatcaaag agcaaactag gaagctagtc gcaagttgct
     5401 caaaacactg ttttgaggtt gcagatagag ctaacgtggt ttgaagagat tttcgaagag
     5461 tattaaagac agtgtgacta tgcttgtcaa tagataggaa atcaaaatga aggatggaaa
     5521 tctgagccaa acatcataag tgctataatg aacagaagta agaattgcac gataagtttt
     5581 ctaaaaccat aggaatcgtc ccctttcttc atcttcatta tagcacatat acatcagttg
     5641 tacaaataat atgatatttt tttattagtc ctcagacaag catattataa agcgtttcat
     5701 taccatttaa gttaatataa gctggatcaa aaccttccat tctacggatc aaacctgcat
     5761 aatcatgctt atctgccaaa gcgatcccaa tcaatactgg gcctgttccc ttgctagctc
     5821 gtttgatata ctcaaaacgt gtgatatcat catttggccc caggatatca tttacaaact
     5881 cacgcaaagc tcctggacgc tgtgggaaat tgaccacaaa gtaatgtttg ataccatcat
     5941 aaatcaaggc acgctcttcc atttctggca tacggttgat atcattattt cctccagaaa
     6001 tgatacaaca aatggttttc cccttaatat attcagctaa aacctctaaa gaggcgatac
     6061 tagccgctcc agcaggctct gcgactatcc cttgcttaga gtaaaggtca atcaaggttt
     6121 cagaaatcaa tccctcatcg acacctacca aagtttgaat atgttgacga gttgcttcat
     6181 aggtcaactg acctaccttt tgcacagcaa tcccatccgc aaatttatca atttccttga
     6241 gtttgactgg acctccagcc tcaaaggcag ctttcatgga acgcgctcca ttcgcctcta
     6301 ctccgataac ctcaatctct ggacttgttt ccttgatata ggtagaaacc ccggcaatga
     6361 gaccgccacc accaacagga accaagacag catcaaaatc aatcgattct tttcgagctt
     6421 cttctaaaat ctcataagca actgttcctt gacctgcttg aacatgagca tcatcaaaag
     6481 gatcaataaa ggtacgattt tcagagactg taaattcttg agctgctttg gctgaggcat
     6541 caaaggtatc tccaactagt ttaatagtta caaaatcccc accaaaaaag cgaacctgac
     6601 caatcttttg ttgtggcgta gtaataggca taaagatagt agcaggaatt ttcatttcat
     6661 tacaagtata ggctactccc tgcgcatgat ttcccgcaga agcgcagact accccacgtt
     6721 cacgttcttc cttgctgagc tgggaaatgg cataataggc accacgaatt ttaaaggagc
     6781 gaacacgctg ggcattttct tttttcaaat aaatcttagc accatacttc tccgataaat
     6841 aatgatcgta atccagtgga gtattcacaa ccacaccgtt caagaccttg tgagccttga
     6901 ttatatcttt tgaacttaac atataaaacc tctttttcta taaaaaacag tcactaatga
     6961 ctgtttttta gttattcatc tccgaaaact tcagtaacac tttcatggta tttatgagcc
     7021 atacgaatcg aaaactcttt aggaagttca taacgatttg tggaaatcca atcatataac
     7081 cattctacca aactttcttc actatcatta cgatggaaga taaaatagtt taaaatttct
     7141 ttatattcta catcattcaa atccaacgtg tctacaaatt gactacgagg aacaaaatta
     7201 gaatctaatt ttcttagttg atctgtcaat tctcccaatt gtaaatccaa ctgaaaaaat
     7261 agtttttgca gttgcctatc agtttcatca catcctgtct tgatagaaaa caaattggta
     7321 atattcatat gatttcaacc cctaaataag tacatctaat atcccacgaa tagctgaagc
     7381 taaagttttc gcagtccagt catttaaacc cgattctttc aatccagatg caataatttg
     7441 ctctatttga tataaaccgc catctatcgt ctcatttatt ctgcgaagag gaccttcaat
     7501 ataggataaa gcttctccga atctaacagc tgatttaggt cctaatgatt taccaactat
     7561 atttgttaat gttttttatt tctcaaaatc catttcgcta tataacgagc agatttagtc
     7621 gcaccagctc tctcaaacgg agaatgaatt tcaagacctt cttctctagc tatttgtgcc
     7681 aatttgaaga attgttcaaa ggtcatatgc aacctaccat cttcaaaatt agcatcatca
     7741 taaatgttaa ttacagcatt ttcatcatac gaccaatctg ctttattttg gtctgctagc
     7801 actattaccg acggtgtaat tacattatac aactagaacc aataataacg atgcaatttt
     7861 tctcataatc tttttcataa aatcatctcc agcgctatat atttctaatt agttatagat
     7921 tttgaatgca tcatcgtcgt ttttaccaac gaatggcatt gctttacgca attctgcacc
     7981 aactttttca atttcaaggt tagctgcttg ttcacggtaa gcagtcaatt ttggacgtcc
     8041 agctttatag tcatttacaa agtcatttgc aaatttacca ttttggatgt ctgccaagac
     8101 agccttcata ttttctttaa cttgttcagt gattacacgt ggacctgata catagtcacc
     8161 gtattcagca gtgtttgaaa tagattgacg cattttcttg aatccacctt catagatcaa
     8221 gtcaacgatc aatttcattt cgtgaagaac ttcaaagtaa gccaattctg gagcgtaacc
     8281 tgcttctgtc aagacttcga aacctgcttc gataagggca gtcaaaccac cacaaagtac
     8341 agcttgttca ccaaacaaat cttcttcagt ttcttctttg taagttgttt caagaagacc
     8401 tacacgagcc gctccaacac ctttacacca gtccatagca atgtttttag catttcctgt
     8461 tgcatcttgg tatactgcat aaagagctgg aacaccaaat ccttcttcgt aagtacgacg
     8521 taccaagtgt cctggtcctt taggagcaca catgaagaca tctacatccg caggaacttt
     8581 gataaattca aagtggatgt tgaaaccatg ggcaaatcca actgcgtttc cagcttccaa
     8641 gtttggagcg atttctgctt cgtacaattc ttgttgaatt tcgtctggcg ccaagatcat
     8701 gataacatca gtcaacttag tagcttctgc tactgtgtaa gtatcaaatc catcttcttt
     8761 tgctttatca aaagatttac ctggacgtac acctataata acgtcacgac ctgaatcacg
     8821 caagttttga gcatgcgcat gcccttgtga accataaccg ataacggcga tttttttacc
     8881 gtcaagtgct gctactttaa catctttttc atattccatt tgaactgtca tagcttttct
     8941 ctcttttcta ttatttattg ccttttaggc tggtttaata aatttaagtt ggatttttaa
     9001 tcgcgggtaa atccagttgc acccgttcga gcaatattgc gaataccgta tgggcgaatg
     9061 actctcaata gggcttcgct cttttctgca tttcccgtca tctgaatggt aatcgagctt
     9121 ggcgctacgt ctaccactgt tgcacggaaa ggttgaataa tcgctaaaat ctcagctctc
     9181 ttctcagctg gcgctgacat cttaaccaaa atcacctcgc gctccaaatg aggcttgtct
     9241 gtaatatctc gaatgcgaat cacatcaatc tgacgattga gttgtttgat gatttgctcc
     9301 acttcatcat gagaagcaac atcaataata atagtgatac gcgatacatt cggatcttct
     9361 gttgctccaa cagagatgct ttcaatatta acctgacgac gagataggac acctgtaaag
     9421 cgattgagga ctcctgaacg attttgtagt tttgctgtta acattctacg catggaactg
     9481 cacccccaac atctcatgat tactcttacc agccggtacc attggtaaca cctgttcctt
     9541 acgagaaata tctacctcaa ttagcatagg aacatcctca gtgatgactt caaggtcttg
     9601 agccaaggtc tcaggattgt caaacttata gtttttaata ccataagcct gcgccatcaa
     9661 ttggaaatca ggaagggtat caaagaccga ctctgatgtt ctgccttcat agaaggattc
     9721 ctgccactgg cgaaccattc cgagtgaatg attgttcagc ataaccacct tgattggcac
     9781 cttgtaaata ttcaaaatag ccaactcctg gttagtcatt tggaaaccac catccccaac
     9841 aaacaagact acttccttat ctgggttagc aattttagca ccgattgctg ctggaattcc
     9901 aaagcccatt gttcccaaac cacctgaagt cactaactga cgttcatttt ggtagggata
     9961 atactgagct gtccacattt ggtgttgacc aacgtctgtt accacaatgg catctccatt
    10021 cgtcaattca ccaattcgtt caataactgc ttgcggttga accacacgct ctttcttgtc
    10081 ataagaacga acacgattct tgtctttagt gactttctca atccactttt cagtattgtt
    10141 gtgaactgtt ggttctgcta gcaacatttg caaggccttc ttagcatctc caactacagg
    10201 aatgtctgca ctgataatct tgccaatctc agctgggtca atatcaatgt gggcaacctt
    10261 agcattctta gcgaaagtct taggattccc cgtcaaacgg tcatcgaaac gagaaccaat
    10321 actaatcata aagtccgctt ccgtcatggc aatatttgct gcgaatgacc cgtgcatgcc
    10381 tcccattcca agaaagagtg ggtgactcgt tgcaattgtt ccttgtccca aaagactggt
    10441 taccactgga atttgatagc gttctgcaaa ttcatttagt tccgtagcag cctcagcata
    10501 actaattcca ccaccagcta acaagactgg ctttttagcc ttggacaatt gcttcaagat
    10561 tttcttgatt tgcatatcat tcggctcaag agtcggctga taacttggta aattcacttc
    10621 tggtgaataa atgaaatctg tttctaaagc agatatgtct tttggtaggt caattacaac
    10681 tggccctgga cggcctgtag ttgcgatatg gacagcttcc gtaatgatac gcggaatatc
    10741 agctgtctca cgaacttgat aattgtactt agtgattggc atggtaattc ctacgatgtc
    10801 tgcctcctga aaggcatcct tcccaatccc tgctcgcgcc acctgacctg taaagaccaa
    10861 aaggggaacg ctatcgctca tagcatccgc aatccctgta atggcatttg ttgctcctgg
    10921 tccactagtg acgacggcaa cacccaactt tccagttgat ttggcataac cttcagcttc
    10981 atgcaaacaa ccttgctcat ggcgccctag aatgtggcga atgcctttaa aattatatat
    11041 cgcatcataa aaaggcaaaa ccgcaccacc aggataacca aagatggtat caactcctaa
    11101 atcacgaagt gtttccaaaa ctaggtccga ccccgtctta ggagattcta aactgatttt
    11161 ctccattgtt cccctttctt tcctcttaaa aataacttgt tactatcata ccattttttc
    11221 aaaatttttc aagataaaag aagaaatttt ctgaattttc tattttaacg tttatttatg
    11281 aatattattt ttatttttat ttaaaagata ccgatttcat ttactaaaaa agaaaaaaga
    11341 actgatttct cagtccttca ttaatcttat tccacactaa ataggtatgg gtaaacaggt
    11401 tgttgacctt ggtgaatctc gacttcaacg tcttcgaatt cttctacgat ttcttgagcg
    11461 atttcattgg caagttcttc gcttccgtct tcaccgacat agaaggttac gatttcactg
    11521 tcttcatcca acatatgttt caaggtttca gtcaatgttt ggtgcatatc agggtttgac
    11581 acaagaattt ttccatccac catacctaga ttatcgtttt catggatttc taagccatcg
    11641 atcgttgtat cacgcacggc tgttgtgacg cttccgctaa cgacatcgct aagagcagct
    11701 gtcatacgct cttggttttc ttcaatggac ttgcttggat caaaggcaag aagacttgtc
    11761 ataccttgag gaagagtgcg agcctctacc actactgctg gttgctccaa aacttctgcc
    11821 gcagattgag ctgccatgaa gatgttcttg ttgtttggca agaagatgat gttacgggca
    11881 ttgacctgtt caacagcctt gataaagtct tctgttgaag ggttcatggt ttgaccgcct
    11941 tcgataacat agtccacgcc ttgagaacag aagatatctg ctagaccttt accagccacc
    12001 acagcaatta aagcatactc tttttcttca gccgacttga taacttgagt agcttctttc
    12061 tcaacctgtg cttcgtgttg gttacgcata ttgtcaactt ttaccttgac caagctacca
    12121 tatttgagac cttcttgcat aacaagtcct ggatcttctg tatgaacatg gactttgaca
    12181 atttcatcat cgttaacaac gaggagagaa tccccaagct catccaagta gttacggaat
    12241 tcatcgtaat caaaatcttt agcataggtt ggaccttgct taagagctac catgatttca
    12301 gtacagtaac caaacgtgat gtcctcagtc gctacgtgac cagctacaga cttatgatgc
    12361 tctacattga tcatctcact catgttggca ggagtcgcta caaagtcctc agatgcaata
    12421 tattcgccag taagggctga aaggaaacct tcgtagatga agaccaatcc ttgaccacct
    12481 gagtccacaa cgccaacttc tttcaatact ggaagcatgt ctggtgtttt agctagagct
    12541 gttttagcac cttccaaggc tgcgcgcatg acttcaacag tgtcatctgt ttgctcagct
    12601 tttttcttag caccgatagc agctccacga gaaactgtca aaatcgttcc ttcaacaggt
    12661 ttcatcactg ccttataggc aacttccaca cctgattgga aggccagagc caagtcttga
    12721 cctgttaact cgtctttatc cttgatagct tgggaaaatc cacggaaaag ctgagacgta
    12781 atcactcctg agttcccacg cgcacccatc aaaagccctt tagcaagaat gctcgctact
    12841 tctccaactg tagaagctgg cttgtctgca acttctttag caccattttc aatggtcatt
    12901 cccatatttg tcccagtatc tccatctgga actggaaaga cgtttaatga attgacatat
    12961 tcagcttgct tattcaagcg agttgatgca gcctgcacca tttcttgaaa taagctagta
    13021 gtaatttttg acacggttat tctcctacaa ctttgatatt ttgaatgtag acatttacag
    13081 tctgagcagt aattccaagc tggttttcca agctaaaggc aacacgctct tgaatgtttt
    13141 ttgacacttc actaatcttt gttccgtagc ttaacacggt atatacatca actgcaatac
    13201 tgccatcttc ggctgccttt acgacgacac ctttagaata attttcctta cctagcaggg
    13261 cttggaaatt atctttgagg gcatttttac tagccatacc gaccacacca aaaatctcag
    13321 ttgctgctcc acctacgacg gttgcaatca cttcatctgt tagttcgatt tgaccatctt
    13381 ttgtattaat ttttacagtc atccttttta cctcaactag ttgatactct attttatcat
    13441 atttcagccc aagtgtaaaa gcagaatgat gtatcagcgg atatttactc tatttttcaa
    13501 acgatgttat acccacaata aaagaaaaaa gaccctaagg tctcctttgc ttttattatt
    13561 aaacgcgttc aactttacct gatttcaaag cacgagctga agcccaaact tttttaggtt
    13621 taccatcgat aagaacagta actttttgaa ggtttggttt tacggcacgt tttgtttggt
    13681 tcatcgcgtg tgaacggttg tttcctgata cagtcttacg acctgtaaag taacatactt
    13741 tagccattgt gttttcctcc tattagatct aatatagcgg atgtgctagc accacatacc
    13801 gtactatgtt atcacacttt cttgtttttt gcaagggaat tggaagattt tttatttgtg
    13861 tcttaaatca ggtcttgcgt gacattttct gctctccaca tgccattgtt gattaacaga
    13921 acaccagaat taaaattatg tgtataaaaa tcatctctaa ctgcagctaa gggtatagcc
    13981 gtcaagtcca aatcccacag ctcatctatc gattttctta caacaatatc taaatccaaa
    14041 tacagtacac gagactcgct tacatacttt ggaataaaat acctaaaaaa gccgcatatg
    14101 aaagtccctc aaaggggaga cgataacctt tcagaatact actgtcaatc taaacattca
    14161 caatctcact attcaaagtc tctagtcttt tttccatcaa ttggaaccat tctcgcggaa
    14221 ggtcatcatt aaaaacataa aacttaagat tataatagat gaacacaaag agattttatt
    14281 gttgtttcaa ctttatccat ataagcatta tctgcaccta agacaatcgc ttttttctct
    14341 tctttcactc tttatctcat ttctttttat tcccatcata tgtttctacg taaccattat
    14401 tttcgcccat tcgttcgtaa aaccatacca gtggagattt tagatgaagt cccattacgg
    14461 tttacaattt ttacattacg acacggagtt ttacaaatcg atttcatttg ccaaacgtag
    14521 ttagtaaggc agttagctag ttcgccaaat agcgactagc gtccaacaat ttggaacttt
    14581 agttccaatt gttggtactg agtcacatct tctcctctaa ctctacgtct ggatacttgt
    14641 ccgcaaacca gcggagggca aagtcatttt caaagagaaa gactggttgg tcaaaacggt
    14701 ctttggctaa gatattgcga cttgacgaca tccgttcatc caagtcctca ggcttgatcc
    14761 aacgaacggt ctttttaccc attgggctca tgaccacttc cgcattgtat tcgccttcca
    14821 tacggtgttt aaagacttca aactggagtt gaccaacagc tcccagcatg tactcacctg
    14881 tttggtaatt cttataaagc tgaacggctc cttcttgcac caattgctca atccccttgt
    14941 ggaaggattt ttgcttcata acattcttag cagaaacttt catgaaaatt tcaggagtaa
    15001 aggttggcag tggttcaaat tcaaacttgt tttttccaac cgtcaaggta tccccaacct
    15061 gataagtacc ggtatcgtaa accccgataa tatcacctga tacggcattg gtcacattct
    15121 cacgactctc cgccataaac tgggtaacat tagatagttt ggcaccctta ccagtacgag
    15181 ggagattgac actcatgcca cgctcaaatt cgcctgatac gatacggaca aaggcaatac
    15241 ggtcacggtg acgaggatcc atgttggctt ggattttaaa gacaaagcct gagaaatcct
    15301 tgtcataagg atccacaatt tcaccgtctg ttttcttgtg accatgtggt tctggagcaa
    15361 acttgaggaa gatttcaagg aaggtctgca caccaaagtt tgtcagggct gaaccgaaaa
    15421 agacaggcgt caattctcca gccagaatag cttcctctga aaactcattc ccagcttcat
    15481 ttaaaagctc aatgtcatcc ttgacttgct cgtagaaagg attgctacca aagagtttgt
    15541 ccccgtcttc tagactggca aaacgctcat cccctttgta aagctctaaa cgttggttat
    15601 agaggtcata caagccctca aaggctttcc ccatcccgat aggccagttc atagggtagc
    15661 tagcaatgcc caagatttct tccaattctt gcaagagatc caaaggctca cgaccgtcac
    15721 ggtccagctt gttcataaag gtaaaaactg gaatgccacg atgtttcaca acctcaaaca
    15781 atttcttggt ttgagcctcg atccccttgg cagagtccac gaccatgacc gcagcatcca
    15841 ccgccatcaa ggtacgatag gtatcttctg agaagtcctc gtgccctggc gtgtctaaga
    15901 tattcacgcg cttgccgtcg tagtcaaatt gcataacaga tgaagtaaca gaaatcccac
    15961 gttgcttctc gatatccatc cagtcagatt tagcaaaagt ccctgttttc ttccctttta
    16021 ccgtaccagc ctcacgaatc tcacccccaa agtagagtaa ctgctcagtg atggttgttt
    16081 tccccgcgtc cgggtgggag ataatggcaa aggtacgacg tttcttaatt tcttcttgaa
    16141 tattcataag ttctctttct ttgattctct atttttcttg tttcaatagc tgagaatgat
    16201 ttttacattg gattttacca ttcctttcaa cattccatta tatcggattt tagcattttt
    16261 ttcaatttct atttcttttc acttccccct cccttattta taggaaaata tggtaaaata
    16321 gaacagacta aaaatcatca tttcacgaaa ggatgcaaga tgaaaattac gcaagaagag
    16381 gtaacacacg ttgccaatct ttcaaaatta agattctctg aagaagaaac tgctgccttt
    16441 gcgaccacct tgtctaagat tgttgacatg gttgaattgc tgggcgaagt tgacacaact
    16501 ggtgtcgcac ctactacgac tatggctgac cgcaagactg tactccgccc tgatgtggcc
    16561 gaagaaggaa cagaccgtga tcgcttgttt aaaaacgtac ctgaacaaga caactactat
    16621 atcaaggtgc cagctatcct agacgatgga ggagatgcct aatgactttt aacaataaaa
    16681 ctattgaaga gttgcacaat ctccttgtct ctaaggaaat ttctgcaaca gaattgaccc
    16741 aagcaacact tgaaaatatc aagtctcgtg aggaagccct caattcattt gtcaccatcg
    16801 ctgaggagca agctcttgtt caagctaaag ccattgatga agctggaatt gatgctaaca
    16861 atgtcctttc aggaattcca cttgctgtta aggataacat ctctacagac ggtattctca
    16921 caactgctgc ctcaaaaatg ctctacaact atgagccaat ctttgatgcg acagctgttg
    16981 ccaatgcaaa aaccaaaggc atgattgtcg ttggaaagac caacatggac gaatttgcta
    17041 tgggtggttc cggtgaaact tcacactacg gagcaactaa aaacgcttgg gaccacagca
    17101 aggttcctgg tgggtcatca agtggttctg ccgcagctgt agcctcagga caagttcgct
    17161 tgtcacttgg ttctgatact ggtggttcca tccgccaacc tgctgccttc aacggaatcg
    17221 ttggtctcaa accaacctac ggaacagttt cacgtttcgg tctcattgcc tttggtagct
    17281 cattagacca gattggacct tttgctccta ctgttaagga aaatgccctc ttgctcaacg
    17341 ctattgccag cgaagatact aaagactcta cttctgctcc tgtccgcatc gccgacttta
    17401 cttcaaaaat cggccaagac attaagggca tgaaaattgc tttgcctaag gaatacctag
    17461 gcgaaggaat tgatccagag gttaaggaaa caatcttaaa cgcggccaaa cactttgaaa
    17521 aattgggtgc tatcgtcgaa gaagtcagcc ttcctcactc taaatacggt gttgccgttt
    17581 attacatcat cgcttcatca gaagcttcat caaacttgca acgttttgac ggtatccgtt
    17641 acggctaccg cgcagaagat gcgactaatc ttgatgaaat ctatgtaaac agccgtagcc
    17701 aaggttttgg tgaagaagtg aagcgccgta tcatgctggg tactttcagt ctttcatcag
    17761 gttactacga tgcctactac aagaaggctg gacaggtccg tacacttatc attcaagatt
    17821 tcgaaaaagt cttcgcggat tacgatttga ttttgggtcc aactgctcca agtgttgcct
    17881 atgacttgga ttctctcaac catgacccag ttgccatgta cttagccgac ctcttgacca
    17941 tacctgtaaa cttggcagga ctgcctggaa tttcgattcc tgctggattc tctcaaggtc
    18001 tacctgtcgg actccaattg attggtccca agtactctga ggaaaccatt taccaagctg
    18061 ctgctgcttt tgaagcaaca acagactacc acaaacaaca acccgtgatt tttggaggtg
    18121 acaactaatg aactttgaaa cagtcatcgg acttgaagtc cacgtagagc tcaacaccaa
    18181 ttcaaaaatc ttctcaccta cttctgccca ctttggaaat gaccaaaatg ccaacactaa
    18241 cgtgattgac tggtctttcc caggagttct accagttctc aataaagggg ttgttgatgc
    18301 cggtatcaag gctgctcttg ccctcaacat ggacctccac aaaaaaatgc actttgaccg
    18361 caagaactac ttctaccctg ataatcccaa agcctaccaa atttctcagt ttgatgagcc
    18421 aatcggttat aacggctgga ttgaaatcga gctagaagac ggtacgacca agaaaattgg
    18481 tatcgaacgc gcccacttag aggaagacgc tggtaaaaac acccacggta cagacggcta
    18541 ctcttacgtt gaccttaacc gccaaggggt acctttgatt gagattgtat ctgaagccga
    18601 tatgcgttcg ccagaggagg cctatgctta tctgacagcc ctcaaggaag ttatccagta
    18661 cgctggcatt tctgacgtta agatggaaga aggttctatg cgtgtggatg ccaacatctc
    18721 ccttcgccct tatggtcaag aaaaattcgg taccaagact gaattgaaga acctcaactc
    18781 cttctcaaac gttcgtaaag gtcttgaata cgaagtccaa cgccaggctg aaattcttcg
    18841 ctcaggtggt caaatccgcc aagaaacacg ccgttacgat gaagctaaca aaacaaccat
    18901 cctcatgcgt gtcaaggaag gggctgctga ctaccgctac ttcccagaac cagacctacc
    18961 cctctttgaa atttctgacg agtggattga ggaaatgcgg actgagttgc cagagtttcc
    19021 aaaagaacgt cgtgcgcgtt atgtatctga ccttggttta tcagactacg atgctagtca
    19081 gttgactgct aataaagtca cttctgactt ctttgaaaaa gctgttgccc taggtggtga
    19141 tgccaaacaa gtctctaact ggctccaagg ggaagtcgct cagttcttga atgctgaagg
    19201 taaaacactg gaacaaatcg aattgacacc agaaaacttg gttgaaatga ttaccatcat
    19261 cgaagacggt actatttcat ctaagattgc caagaaagtc tttgtccatc tagctaaaaa
    19321 tggcggtggc gcgcgtgaat acgtggaaaa agcaggtatg gttcaaattt cagatccagc
    19381 tatcttgatc ccaatcatcc accaagtctt tgccgataac gaagctgctg ttgccgactt
    19441 caagtcaggc aaacgtaacg ccgacaaggc ctttacagga ttccttatga aggcaaccaa
    19501 aggccaagcc aacccacaag ttgcccttaa actacttgca caggaattgg cgaagttgaa
    19561 agaaaactag acagaacaaa accagcccta aggttggttt tttcttctct accaactccc
    19621 aataactatt ttggctttat ttccagagta ttttatggta aaatgaagag taataatatt
    19681 tattaaagag gtaaaaacat gattgaagca agtaaattaa aagctggtat gacctttgaa
    19741 acagctgacg gcaaattgat tcgcgttttg gaagctagtc accacaagcc aggtaaagga
    19801 aacacgatca tgcgtatgaa attgcgtgat gtccgtactg gttctacatt tgacacaagc
    19861 taccgtccag aggaaaaatt tgaacaagct attatcgaga ctgtcccagc tcaatacttg
    19921 tacaaaatgg atgacacagc atacttcatg aatacagaaa cttacgacca gtacgaaatc
    19981 cctgtagtca atgttgaaaa cgaattgctt tacatccttg aaaactctga tgtgaaaatc
    20041 caattctacg gaactgaagt gatcggtgtc accgttccta ctactgttga gttgacagtt
    20101 gctgaaactc aaccatctat caaaggtgct actgttacag gttctggcaa accagcaacg
    20161 atggaaactg gacttgtcgt aaacgttcca gacttcatcg aagcaggaca aaaactcgtt
    20221 atcaacactg cagaaggaac ttacgtttct cgtgcctaat ctctagaaag aggtcattct
    20281 atgggaattg aagaacaact tggcgaaatc gttatcgccc cacgtgtact tgaaaaaatc
    20341 attgctatcg ctactgcaaa ggtagagggt gttcactctt tttcaaacag atcagtgtct
    20401 gatacccttt caaaactttc actcggccgt ggcgtttatc ttaaaaacgt ggacgaagaa
    20461 ctcacagcag atatctatct ctaccttgag tacggagtaa aagttcctaa ggtagcggtt
    20521 gctatccaga aagctgtcaa agatgccgtc cgtaatatgg ctgatgtaga actcgctgct
    20581 atcaatattc acgttgcagg tatcgtccca gataaaacac caaaaccaga attgaaagat
    20641 ctatttgacg aggacttcct caatgactag tccactatta gaatctagac gccaactccg
    20701 taaatgcgct tttcaagctc tcatgagcct tgagttcggt acgaatgtcg aaactgcttg
    20761 tcgtttcgcc tatactcatg atcgtgaaga tacggatgta caacttccag cctttttgat
    20821 agacctcgtt tctggtgttc aagctaaaaa ggaagaacta gataagcaaa tcactcagca
    20881 tttaaaagta ggttggacca ttgaacgctt aacgctcgtg gagagaaacc tccttcgctt
    20941 gggagttttt gaaatcactt catttgacac tcctcagctg gttgctgtta atgaagctat
    21001 cgagcttgca aaggacttct ccgatcaaaa atctgcccgt tttatcaatg gactgctcag
    21061 ccagtttgta acagaagaac aataaaaaga aaaagtgttt gatatctatc aaacactttt
    21121 tctttgcctc ccactatcta aaaaaatgat aatagatata attgtaaaca aaaatccaga
    21181 taggttttgc atgattgaga aagttaaaaa aactatggca gagaatcgtt aatctcagat
    21241 tgtcggtaga acgataaaca agggcaaaaa agaaaccaat cagactataa tataataaac
    21301 taattggatc tctgtgagat agtatcaaat ggctaatccc aaagataagg cctgataaga
    21361 tgacatctaa atagtacttt gacttaggaa agaaggtatt catcaaatac cctctatcaa
    21421 gagtctcctc aaaaacagga ccgatgatta caagcaggac aaaagataag atagtcgata
    21481 aaaaggttgg ttgtccattt gaaagaacca cggtaaaata ctcatcatga atattcctat
    21541 ggttaatcaa atgagcatag cgtgcctaaa aattaccgag aatctgataa accacatacg
    21601 ttgcaaataa gtagaagaca aatgaccagt tccagctctt tttttcaaag ataaagagca
    21661 tctttttctt ttttaacctc caaatcaata gaaggaaact tcccactaat accattgtta
    21721 aaataagaga atagacatca gctcctaacc ctaaaatgat cgtcacatac aatccaattg
    21781 tttgtggtaa ataggtagat agtaaaataa taagcaaaaa tattccaaat tgtcttagtt
    21841 tttttgtgtt tctcatcgta cttttttgaa agattaccct gctcggaagc cgtacttcca
    21901 agcatctata taagaattaa gtgccccttg cctcatatag ggagcaaatt ctctataata
    21961 taaccatcta ctatatccat cttcccaaac agcaagacca cctgaagttt gctccaagtc
    22021 ctcagttgaa agaactgtaa atgtatttgt acctgtcatt gcaagtacct tcttaaaata
    22081 gattgttgta ggctcacatt tatagtatat ttcttttttt gtctatttta tagtctatct
    22141 cctcaactgt caatttttca acctgaattg catttttcca taaaaaatga gacctttcta
    22201 gtctcattta gtcattctta gtattttcta aatcgttgat agcgttcttc cagcaactct
    22261 tctagcggtt tttgtgaaag tctagccagc tccgtttgga gttctttttt gacactctta
    22321 atcagttctt tactagaaag tcctacttca gaaatcacct tatccaccac gtccatttct
    22381 aacagttcat gcgaagtgat tttcatcagt tctgctgctt ccatggcgcg agtaccgtcc
    22441 ttccataaaa tggaagcaaa gccttctgga ctgagaatgg catagataga attttccagc
    22501 atccagacac ggtccgcgac agctagagcc agagccccgc ctgaaccacc ttcaccgata
    22561 ataatggcga taataggaac tttcaggtca ctcatttcca tgagattgcg agcgatagct
    22621 tccccttgac cacgttcttc tgctccgaca ccaggataag cacctgctgt attgataaag
    22681 gtcacaactg gacggccaaa tttctcagcc tgtttcatca accgcagtgc ctttcggtaa
    22741 ccttctggat gtggttggcc aaaattccgt ttgaggttgt cttgcaaact cttgcctttt
    22801 tggataccaa ccactgttac agcttggtct ccaagccaac caataccacc aacaactgca
    22861 ccatcatcac gaaaagaacg gtcaccatgt aattggataa attcatcaaa aatgcctgtc
    22921 gcaaagtcca aggttgtcaa gcgactctgc tcacgcgctt ctctgactat ttttgcaata
    22981 ttcatctagg actccctcca tgcaatctga ctaggctagc aatcgtatct ggtaagtctc
    23041 ttcttttgac aatagcatcc acaaagccat gttctaatag gaattctgcc ttttggaaat
    23101 cctcaggcaa gctttcacga accgtatttt caatcacacg acgtccagca aaaccaacca
    23161 agctctgtgg ttcagccaga atgatatcgc cttccatagc gaaagaagct gtcacaccac
    23221 cagtcgttgg atctgtcaaa atggtcaggt aaaagagacc agcatttgaa tggcgtttaa
    23281 ccgccgcaga gatcttagcc atctgcatga gactcatgat tccttcctgc atacgggctc
    23341 caccagaggc tgtgaatagg acaactggca atttttcgac agtcgcatac tcaaacaaac
    23401 gagtgatttt ttcacctaca accgtaccca tagaagccat gataaagtta gaatccataa
    23461 tcccaagagc cacagtctga cctttaataa gagcagttcc tgtcacaacg gcttcatgca
    23521 gacctgtttt ttcacgcata gatgccagtt tcttttggta accagggaaa tgcaagggat
    23581 ccttgctttc aatccctgta aacaattctt tgaaggttcc catatcaatc gtcaaagcca
    23641 agcgttcttg ggcagaaata cgaaaggtat agctacagtg cggacagata cgttcacttc
    23701 ccagatcctt ctgatagatg gtatgcttac agcctggaca ctgggaaaat aattcatctg
    23761 gaacctctgg cttagcttga ggtttttccc taaccgaacg attgggattg attcgaatat
    23821 acttatcttt tttactaaat agagccattg attccccttt tcggtttaaa ctcttaaagt
    23881 cattttattc tttttcttga tatttaggta agaaggtttc catcaagaag gaagtatcat
    23941 aatccccagc aatgacattg cgatctgaaa tgaggtcaag ctggaaatct gcattggtct
    24001 gcactccttc aatctctaat tcatagaggg cacgttgcat tttcatcaag gcgtcaaaac
    24061 gattttcgcc gtgtactatg attttggcaa tcatactatc ataataaggc ggaatggtat
    24121 aacctggata aactgctgaa tccacgcgca agccaactcc accacttggc agatagagat
    24181 tagtaatctt acctggactt ggagcaaagt taaaggctgg gttttctgca ttgatacgac
    24241 actcgatggc atgaccgcgt aggacaatat cttcttgctt aacagacaaa ggctgacctg
    24301 ccgcaatgca aatctgttcc ttaacgatat caacacctga aacaaactct gttactggat
    24361 gttctacctg aacacgagta ttcatctcca tgaaatagaa attgctactt gcttcatcaa
    24421 gaagaaattc aatggttcct gcattctcat agccaacaaa ctctgccgct cgaacagcag
    24481 cagcacctat ttcatgacgc agcgtttttc cgattgcaat cgagggactt tcttccaaaa
    24541 ccttttggtt attcctttga agagaacaat cccgttcacc caagtgaatc acatgtccat
    24601 gctcatcacc taggatttga acctcaatgt gccgagctgg atagataacc cgttctatgt
    24661 acatggcacc attgccataa ttggccttgg cctcactaga ggcagtttca aaggcagaaa
    24721 cgaggtcatc tggtttttca accttacgaa tccctttacc acctccacct gctgaagcct
    24781 tgagcataac aggatagcca attttttcag caacaatcaa agcttcttca gagttatgca
    24841 cttctccatc tgaacctggt ataacaggca cacctgcttt aatcatctga gcacgcgcat
    24901 tgatcttatc ccccatcata tccataacat gaccagatgg accgataaac ttgataccta
    24961 cttcttcaca catggtcgca aatttggaat tttcactgag aaatccaaaa ccagggtgaa
    25021 tagcttctgc ctcagtcaag actgcagctg atagaactgc attaatattg agataagact
    25081 ctgttgcctt gccaggacca atacaaactg cttcatctgc caacagcgta tgaagagctt
    25141 ccttatcagc agttgaataa accgctaccg tcgcaatccc caattcacgt gccgcacgga
    25201 taatacgaac cgcaatttca ccacgattgg caattaaaat ttttcgaaac atggagaacc
    25261 tccttagttc ccaattgcaa aagtaagggt accactggct gcaagcttgc catccacttc
    25321 agcctttgct tcaaccacag ctatggtgcc acgacgtttt acaaaagtcg ctgtcataac
    25381 caattggtcg cctggtacaa cttgcttctt gaacttaacc ttatccatac cagcgtaaaa
    25441 gaccagtttt cctttatttt caggttttga taactccaac acaccagcag tttgcgccaa
    25501 ggcttccata atcagaacac ctggcataac tgggtattga ggaaagtggc cgttaaagaa
    25561 aggctcgttg atggtcacat ttttgatagc aacaatggta tcctcgctca cctccaagac
    25621 acggtccact agaagcatag gataacggtg gggaagggct tctttgattc cttgaatatc
    25681 gatcatttga tacgtaccaa tcctttacca aactcaacca tttcttcgtt agagacgaga
    25741 atttccgtta ccacaccatc cttaggagct gggatttcat tcatgacttt catggcttcg
    25801 ataattacca atgtttgacc ttttttgaca ctatcaccaa ctgtaacgaa ggcaggttta
    25861 tctggtccag cagccaagta aaccactcca acaagtggac tctctacaag atttccctca
    25921 ctagccacac ttgcttcagc tggagctgga acttcttctg ctacagtctc tgctggagca
    25981 gatgtaggag ctactggact cggtgttgct agaacgggtg ctggagcgac ttgagttgca
    26041 acttcaggca caggtctcgc ttcattcttg ctaaactgca actcatccgt cccattttta
    26101 taagaaaatt ctctcaaact tgactggtca aattgagtca tcaagtcttt aatatcgttt
    26161 aaattcatac ttatctattc tcccaacgtt tgaaagcaag aactgcattg tggcctccaa
    26221 aaccaaaagt atttgaaata gcgtatggaa tttctttctc caagccttgt ccataaacga
    26281 cattagcttc gatataatct gatacttcac ttgtcccagc tgtcattggt acaaagttat
    26341 gacgcatagc ttcgatggtg acgatagctt ctactgcacc cgcagccccc agcaaatgtc
    26401 ctgtaaaaga cttggttgat gatacaggta cttccttacc aagaacagct acgatagcac
    26461 cactttctcc tttttcattg gcaggagttg acgttccgtg agcattgaca taggctactt
    26521 gctctggaga aatctcagct tcttccaagg ctagtttgat ggccttgata gctccctgac
    26581 cttctggatg tggagaagtc atgtggtagg catcacaagt atttccgtaa ccaaccactt
    26641 cagccaggat agtagctcca cgtttttcag cgtgttcaag actttctaga accaacatcc
    26701 ctgaaccttc acccataaca aagccattgc gatccttatc aaatgggatc gaagcacgag
    26761 ttggatcctc tgtagtagag agagctgtta aggcttggaa accagcgatg gcaaaaggtg
    26821 tgatagaagc ttctgttcct cccaccaaca tcacatcttg gaaaccaaac ttaatggagc
    26881 ggaaggcatc cccaatcgca tcatttgatg aagagcaggc agtattgata gatttacaaa
    26941 caccgtttgc accaaaacgc atggctacat tcccagaagc catatttggt aaagcttttg
    27001 gaagagtcat tggtttgaca cgtttgggtc ctttttcatg aaggcgaagt acctgatctt
    27061 caatttcctt gattccacca ataccagatg caacgataac accaaaacga tccctattaa
    27121 gagcctctac atcaagattg gcatgattta cagcctcttg ggctgcatac aaggcatata
    27181 aagaatagtt atcaaaacgg ttggtatctt tttttacaaa gtatttatcg aacggaaaat
    27241 cttggatttc tgccgcatta tgcacatcaa agtcactatg atcaaatttt gtaatgccac
    27301 caatgccgat ttccccagtt gctaaactat tccaaaattc ttctggtgta tttccgattg
    27361 gagatgttac tccataacct gttaccacta ctcgatttag tttcattctt ttcacctcta
    27421 gctttcgcta catacttaag ccaccatcaa tggcaaccac ttgaccagtt agataatctt
    27481 ggcctgctaa aaatactgtc aaatctgcaa cctgctctgc ctgcccaaat tctttcatcg
    27541 gaatctgagc tagtgtagct tccttaatct tatctgataa gatagctgtc atatcagact
    27601 caatcattcc tggagcaatc acattgactc gtatattccg actagcgacc tcgcgtgcca
    27661 cagacttggt aaagccaatc aagccagcct tagaagcagc atagttagct tgaccaatat
    27721 tccccatcaa accaacaaca ctagacatat taatgatagc accttctctg gctttcatca
    27781 tcggtttcaa gactgattgt gtcatattaa aggcaccagt cagattgacc ttgagcactt
    27841 tttcaaaatc tgcttctgtc atcttgagca taagagtatc ttgggtaatc cctgcattgt
    27901 tgaccaaaac atctactgaa cccagttctg caatagcttg atcaatcata cgcttagcgt
    27961 ctgcaaaatc tgatacatct cctgaaatgg gaaccacctt gataccatag tttgaaaact
    28021 cagcgagcaa ttcttctgag attgccccac gactgtttaa gacaatgttg gctcctgctt
    28081 gagcaaactt gtgggcgatg gcaagaccaa ttccacgact cgaacctgta ataaagatat
    28141 ttttatgttc tagtttcatt tttttccttt caaaacttct acttatttta gtctattttt
    28201 ctaaaagtgc tactaaactc gcttgatctt ccacatgagc taagtgagca gtttgatcaa
    28261 tttttttaac aaaacctgac aagactttcc ccggtccaat ctcgataaag ttgcttatgc
    28321 ctgcttcttg catgacccca atactttcat agaaacgaac gggttccttg acctgacgcg
    28381 tcaagagctg agcaatgtcc tctttttgca tcacagcagc ttctgtattg ccgactaggg
    28441 gacaagtaaa atctgaaaaa cttacctgag ctagagtttc agctagtttc tggctagcag
    28501 gctcaaggag agcggtgtga aagggacctg acaccttaag aggaatcaag cgtttggcac
    28561 ctgcttcttg caaaagttca accgctcgat caactgcaac cacttctcca gcaatgacga
    28621 tttgtgcagg tgtgttatag ttggctggag taaccactcc aagttcagaa gctttttgac
    28681 aggcttcttc aatgacctct actggcgtat tgagaactgc taccatcttg ccagagtcag
    28741 caggagccgc ttcttccata taggctccac gcttagctac caaggcaacc gcatcttcaa
    28801 aatccaaggc gccgcttgcc accaaggcag agtattctcc aagagacaaa ccagcaacca
    28861 tatcaggctg atagcccttt tcttgcaata aacggtagat agcaaccgaa gtcgctagaa
    28921 tggctggttg cgtatagcgg gtctgattga gtttgtcttc ttccgtatcg atgagataac
    28981 gtaaatcata accgagcacc tgactcgctc gatcaatcgt ttctttgaca atcggatact
    29041 gatcatagaa atcccgtccc atccctagat actgggcacc ttgaccagca aataaaaagg
    29101 ctgttttagt catttcttac aactcctgcc cagcgagagg cttcttcttg aattttctta
    29161 gcggctccgt aatacaaatc ttttaggatt tcttcagctg tttcttcttt agaaacaagc
    29221 cctgcgattt gacctgccat gacagagcca ccatccacat caccgtgaac aactgctttg
    29281 gctagggcac ctgctcccat ttgttcaaag atttctaaat caggatcttc ctgcttaaag
    29341 gcatcttttt cagccagttc aaaatctcta gtcaactgat ttttaatagc acgaacagca
    29401 tgaccaaagt gctgagctga aatcgtagta tcaatatccc ttgcttttaa aattttctcc
    29461 ttgtagtttg gatgggcatt cgactctttt gcaactacaa accgtgtccc cacctgtaca
    29521 gcctctgcac ctagcataaa gccagccgca gcaccttcac catccgcaat tcctcctgca
    29581 gcaataacag gaatagatat agctgtggct acctgtcgca ccaaggtcat ggttgttaat
    29641 ttaccgatat gccccccagc ttccattcct tctgcaataa cagcgtctgc accgattttt
    29701 tccatgcgtt tagctaaagc gacactagga acgacaggaa taacgattat cccagcttca
    29761 tggaaacgtt ccatatactt gcttggattt cctgctcctg ttgtgacaac tttaacacct
    29821 tcttcaataa cgagatccac gatatcttcc acaaagggag ataagagcat gatgttgacc
    29881 ccaaagggtt tatcagtcaa tgatttgatt ttatcaatat tagccttgac aacttctttc
    29941 ggggcatttc ccccaccgat aattcctaat cctccagcct tggaaacagc ccctgccaaa
    30001 tcaccatcag caacccaggc catccctcct tggaaaatag gatagtcaat cttcaataat
    30061 tctgtaatac gcgttttcat agtgcctcca accttccttg cttacgtaat agttcgattt
    30121 caccataatt tgacagtcaa actattacct aaacaagagg gagtgggttt ctccctactc
    30181 cttctactaa tattctgctt attttgcttg ctcttcaacg taagcaacca agtcaccaac
    30241 tgttttcaag tcattttctg cttcgatttg gatatcaaaa gcatcttcga tttctgagat
    30301 tacttggaac aagtccaatg aatctgcgtc caaatcatca aaagttgatt caagtgttac
    30361 ttctgatgcg tcttttccaa gttcttcaac gataatttct tgtacttttt caaatactgc
    30421 catgatagga ctcctttaaa ataaatagtt tttttataac aatgtgttca ccacatgatt
    30481 acctaaattg taagaatgag cgtgccccag gtcaagcctc caccgaagcc tgatagaaga
    30541 acagtctggc taccatctaa agggatgaga ccttgttcta cacactctga aagtaaaatc
    30601 gggatactgg ctgcactggt attgccatat tccatcatat tggctggaag tttggctcgg
    30661 tcaacaccaa tttttctagc catcttatcc aaaatacggt cattggcttg atgaagtagc
    30721 agataatcca agtctgtcac ctctatagga gattcatcaa tagtctgctt gatagacttg
    30781 gctacatctc gaatggcaaa atcaaagact gtgcgtccat ccatcttcaa aaacgaatct
    30841 gcactttctt gatctgaaaa tggagaatgc aaacctgaat gcccataagt taaacactca
    30901 ctgcgacttc catcgctatt gaggctctca gctaagaaat gctcttgctc gctagcttct
    30961 aacaagacac caccagcacc atctccaaac aacacagctg ttgatcgatc cgaccaatcg
    31021 actgccttag agagggtttc actaccaatc accaagcctt tttgaaagcg accagaagcg
    31081 ataaactttt cagcagttga aagagcaaat acaaatccac tgcaagccgc ggttaagtca
    31141 aaagcaaagg ctttattagc accaatatta gcttgaacac gagcagctgt agagggcatc
    31201 atcgaatctg gagtaatggt agctaggatg ataaaatcca gctcttctcc tgttattcca
    31261 gcttttgcca tcagtttctt agcaacctct gtagccaaat cactggtaga ttctgttctt
    31321 gaaatatgcc tttgtcgtat tcccgttcga cttgaaatcc actcatcatt ggtatccata
    31381 atctgagcca agtcgtgatt tgtaaccact tgctctggca cataatgagc aacctgactt
    31441 atttttgcaa aagccattat ttcaaatcct ccaaaaattg gtaaagatta gtcaagcctt
    31501 tacccatgac agcaatttct tcctcgctca tgccatcaat aattttttct accatggcct
    31561 tgtggaagcg tttatgcagt ctatgaatca agcgaccctt ctttgtcaaa tgcagatgca
    31621 ccacacgacg atcctgttct gaccgaactc gctcaatgta gcccttacgc tctaaattgt
    31681 tcaaacttgt cgtaacagtt ccaagagtta ccatcaactc ttttgacact tgacttggag
    31741 tcacatctgg agccttaccg atgacatcaa tcgtatgcat ttctttgatg gagatatcct
    31801 taaaacgact acctctcaag ttcacttcct caattacaag gacattgtta aatatagatg
    31861 ttaaatattc attgattcgt tggtagtcca tttttcatat ccctccttct tcaaaaaact
    31921 tttacaatca aaacatttga cagaaagaat tatatcaaaa ttcaaagaat gatgcaagta
    31981 ttttttattt tcctgtaaat ttaggtcttc ttctctccga atgagctcgc actccttctt
    32041 tgaaatcctc tgtttgagct aaggatttct gtaggttcaa ttctaaagta gcgtaaccct
    32101 gccagtcttt aaattggctc tcccaaacca acttcttaat ggcagcatag gaattacttg
    32161 aagcacgtct taatttttta agaagctgtt ctctcgtctt ttcaagtttt tcagcttcag
    32221 aaacgcggta aaccaacccc cattctaggg ctttttctgc cgttaaagcc tctcctgtca
    32281 tagctaattg agcagcacgc gtcacaccga tactgcggct caagagatga attccccctg
    32341 catctggagc caaaccaaca ccaacaaagg cttggataaa cttagcctta tccgtcgcca
    32401 aacagaaatc tgccgcaaca gccatattcg ctgcggcacc tgcaacagca ccgtcaactt
    32461 ccattaaaac aggtttggct atttgcttga ttttataaga aatcgtattg accaactctg
    32521 cgatttttgt caacgatgga atatcatcct catccactgc tcgcttcatc tctaccaaat
    32581 ctcccccaac tgagaagacc tttccattgg cattgattaa gataaaatgc acagctggat
    32641 tttcttctgc caaagtcaga gcttctaaaa tctcctcaca catgggaata tgaaaaccat
    32701 ttgcgacctc aggacggttc aaggtaagga ttgccaagtc ctcttcaagc tgataaataa
    32761 tgtgttccat cagggctcct ttttatttta taagcagttt atactcttcg aaaatctctt
    32821 caaaccgcgt cagcttccat ctgcaacctc aaaacagtat tttgagctga cttcgtcagt
    32881 cttatttaca acctcaaagc agtgctttga gcagtctgcg gctagcttcc tagtttgctc
    32941 tttgatttca ttgagtgtta aattatttca ctgtcaaagt atatcttttt taggagcaga
    33001 aagcaagaaa aaatcgactg aaagtgtctc agccgataag aaaggctcgc tttaggctag
    33061 aaagcatctt attttcttca ttgaaaaaag cctttctttc tgctataatc gtataaaata
    33121 cttactttag gagttcttat gaaagttgtt aaatttggag gtagttctct tgcctctgct
    33181 agtcaattag aaaaagtttt aaacatcgtc aaaagcgatt cagagcgtcg ttttgtagtc
    33241 gtttctgcgc ctggtaaacg caatgctgaa gatactaagg ttacggatgc cctgattaaa
    33301 tactaccgcg actatgttgc gggtaacgat attagcaaga gccaaagctg gattatcgac
    33361 cgctatgctg ctatggttag tgaattggga ctaaaaccag ctgtgctaga aaaaatttct
    33421 aaaagtattc acgccttggc cactcttcct attgaagaaa atgaatttct ctacgatact
    33481 ttcctagcag ccggtgaaaa taacaatgcc aaattgattg ctgcctactt taaccaaaat
    33541 ggtatcgatg cacgctatat gcaccctaga gaagctggga ttgtggtcac aagtgaacct
    33601 ggtcacgctc gcatcattcc atcaagttat gacaagattg aagaattgac aaacaccaat
    33661 gaagtccttg tcattcctgg tttctttggt gtcactaagg aaaatcaaat ctgtactttc
    33721 tcacgtggag gttctgatat tacaggttct atcattgctg ctggtgtcaa agctgacctc
    33781 tatgaaaact ttacggacgt tgatggtatc tttgcagctc accctggtat tatccaccaa
    33841 ccacactcga ttcctgagtt gacctaccgt gaaatgcgcg agttggccta tgcaggcttc
    33901 tcagtccttc atgacgaggc tcttcttcct gcctaccgtg gaaaaattcc tctggttatc
    33961 aagaatacca acaaccctga ccatccaggt actcgtatcg ttctaaaaca cagtaatgat
    34021 gaatttccag ttgtgggaat tgctggtgac tcaggctttg tcagcattaa catgtcgaaa
    34081 tacctcatga accgtgaggt tggatttggc cgcaaggttc tgcaaatcct ggaagaactt
    34141 aacatcggtt gggaacatat gccaacaggt atcgacgatc tttctatcat tctccgttct
    34201 cgccaactaa ctcccatcaa gaaagaagaa atcctgcgtc agttggttca aaaggctaaa
    34261 gtagatcatg cagaaatcga acacgacctt tctatcatta tgattgttgg tgaaaaaatg
    34321 aagagccata tcggagtgac tgctactgcg acacgcgctc tatctgaaaa caaaatcaac
    34381 atccagatga tgtctcaagg ttctagtgaa gtttctatta tgtttgttgt caataaagac
    34441 caagagaaag cagcaattaa agccctctac aatgcctttt ttggagaaag taaggaagac
    34501 taagcatggc tcaatcactt aacaaaacag tactcctcag tacaacaggc acttcctacc
    34561 tctctatagc tgggaaagtt gggaaattcc ttgtcggaga tcaggctttg gaattttacc
    34621 cagatgtcaa tgtcgaacaa tttatccaga ttccttggag ccatatcaat cagattggag
    34681 ccaatgtcac tggacgcaaa atcagccgcc acttcgaagt ctttacagac aaaggaaaat
    34741 tcctctttgc ttcaaaagac tcaggtgcca ttctcaaaat tgcacgcaaa aaactaggca
    34801 atgacaaggt cgtcaaactt ccgaccctga ttcagacaat tagccaaaaa tttaaaaatc
    34861 tatttgcaaa aaagtagaaa ctttagtata atcatagcaa cggataagta ggttatcttc
    34921 ttctttcaga aagtctgcgg gtactgcgag cagataggag ggataggtga aattctaccg
    34981 ttagtaacaa ttacatacac aatcaagtgc acacctgtga agttggatgg aaccgtggcc
    35041 ctgccactcc aacgttttgt caggtgtgct tttttcataa aggagttctt atgttagata
    35101 tcaaacgtat tcgtacagat tttgaagctg tcgcagaaaa attagctaca cgtggtgtag
    35161 atgctgctgt cttgaatgaa atgaaagaaa tcgatgctaa acgtcgtaac atcttggtca
    35221 aggttgaaac tctcaaagca gaacgtaaca cagtttctgc tgagattgcc caagctaagc
    35281 gcaacaagga aaatacagat gacaagattg ctgccatgca aaatctatct gctgaggtta
    35341 aagccttgga tgctgaattg gcagaaatcg atgctaaatt gacagaattt acaacgactc
    35401 ttccaaatat cccagctgac agcgttcctg ttggggctga cgaagacgac aatgtggaag
    35461 ttcgccgttg gggtactcca cgcgagtttg acttcgaacc taaagctcac tgggatctcg
    35521 gtgaagacct tggtatcctt gactgggaac gcggtggtaa ggtaacaggc gctcgcttcc
    35581 tcttctataa aggcctcggt gctcgtttgg aacgtgctat ctacaacttt atgttggatg
    35641 aacatggaaa agaaggctat actgaagtca tcacacctta catagtcaac catgattcta
    35701 tgtttggtac tggtcagtat ccaaaattta aggaagatac ttttgaactc agcgatacca
    35761 actttgtctt gattccaact gctgaagttc ctctggcaaa ctactaccgt gatgaaatct
    35821 tagacggcaa agatcttcca atctacttca ctgctatgag tccgtcattc cgttctgagg
    35881 ctggctctgc cggtcgtgat acgcgtggct tgatccgttt gcaccaattc cacaaggttg
    35941 aaatggtcaa atttgccaaa ccagaagaat cttacgaaga attggaaaaa atgacagcca
    36001 acgctgaaaa cattcttcaa aaactcaacc ttccataccg tgtcgttgct ctctctactg
    36061 gagatatggg cttctcagct gcgaagactt acgacttgga agtgtggatt ccagcacaaa
    36121 acaattaccg tgaaatctca agctgttcaa acacagaaga tttccaagcc cgtcgtgccc
    36181 aaatccgtta ccgtgatgaa gcagatggca aggtgaaact ccttcatacc ttgaacggtt
    36241 ctggacttgc agttggacgt acagtggctg caattcttga aaattaccaa aatgaagatg
    36301 gttctgtgac catcccagaa gcacttcgtc catacatggg tggagctgaa gtcatcaaac
    36361 cataaaaaat aaggtttagc tatttctagc tagacctttt ttcgtaacca aatcagataa
    36421 gcacctagta caaagaataa aatagttagg catataacgg tttcagccaa taccaggtaa
    36481 tccagaaatg gaagtttcaa aattccctga gccatcttga gcgaggtcgc tgtgataatg
    36541 gttgggaagg tgagggctga gaaggctggt tgaaaacctt gttttaaaat gttgggcaga
    36601 cgagttaaaa caaagaaaaa gaaggattga gaagccaaaa tcatgacaat caagacccaa
    36661 gtcggcaggc tggttcctcc tactcgaact agagaagcca agagtagaga gaaaggagca
    36721 cagtagattc cttcttgtcc aagcaaggct agtgggagtg gatatttctt taaatcgcta
    36781 taaataaggg gatagagata gaaggtcaag agaaaaccaa aactcaaggt cgcataggca
    36841 atttcgataa tacctaccag aggataggtc aaggcagcca ctgctatccc cacatagaga
    36901 accgtccaac ttggagtggc atgaaccctc cgccctggac aagcaaactt gatggtaaaa
    36961 ccagcaatca aggtcaaatc caagagaaat gaaaaccacc aaatcccttg tgctaccaaa
    37021 ggaagataag agaatacgcg aaagacatag gtcgataaaa tcatcccagc cataggaaag
    37081 gttgccattc ctgacaaaag agggggcttg gtcaattctt gcttggtttc tttccaatta
    37141 aagagatgca gaattagaaa gtaaatccat aaaaccaaac cagtcagact aaaaagatgg
    37201 gatagaaccg gcaacgtatc taaaataaga tttccagctc ctgccaaacc tagcaaacaa
    37261 cctgaaaata ctaaggggag ttttttcatc ctaacctcca ataatcatgt tagtttcagt
    37321 ataacataaa agcgcttaaa tgaggattta aaaaacgaag tccgcttatt tcagacttca
    37381 ttttactcag atatgaatta ggcataaggt tgcaattctg gattaattgg tgtattagct
    37441 aagttgttgg catagttaca gaggattgct aggctgacac caaaaaccac atccaaggca
    37501 ttttgttgag tgtagccagc ttctaaaaac tcagacaagg cttcatctcc tacacgaccc
    37561 ttggtattga taactgccaa ggtaaactta gctagggtat ccaatttagg atctgtttca
    37621 attggagtac gattgcgaag agcttgaatc aagtcatcat tcatctggat ttgtttgatg
    37681 gaaaaggctg tgtgacctgc gacacagaag gcacaaccat tggtcacggc tgccgtgatt
    37741 tgcaccactt cacgctcaac gggtgtcagg ctgttgcgac ggtggataga tgagacaatt
    37801 tgataggctt ctaaaacagt cggggcattg gccaagagac cgattaggtt gggaatatag
    37861 ccattgttgt ctttttctac tgtttcaaga atttctttca cttctgctgg tgctgactct
    37921 actgtatgga tagtaaatgt tgtcataaga tacctctttt cttattattg acactaatat
    37981 tattggaaaa tcttataaaa tcctgattcc taagtttatc taagataaag ctttattctc
    38041 tcataagatt ttcgttgtta tattagttta tcacacttcc aatcacttgc ataatatata
    38101 ttatatatca ggctgataaa aattatttat aggcaaaaaa atcacacgag ctgtgtgatt
    38161 ccattatttg tcaaaatact ttttagtttc agcaataacg actggcgaca agaccaagag
    38221 ggcaatcaag tttggcagag ccatcaaggc gttaacgata tctgcgataa tccagaccat
    38281 atccaactcg ataaatcctc ctaacaagac catgagcaca aaaaacacac ggtagagcca
    38341 gataaagcga gccccaaaga ggaactcaaa acagcgttct ccgtaatagt tccaacctag
    38401 aatcgttgta aaggtaaaaa gtacaaggaa gatggtcaag agggcaggcc caaagtgtga
    38461 aaagactgtt gagaaagctg actgagtcaa ggcaacccca ttcaagtcac cactccaaac
    38521 tccagttacc aagatggtca aaccagttag agtacaaatg atgagggtat caataaaggt
    38581 tcctgtcatg gaaatcaaac cttgctctac tggttcattt gtcttggcag ctgcagctgc
    38641 aataggagca gaacccagac cagattcgtt tgagaacaca ccacgcgcca caccattttg
    38701 aatagccatc cgaacgctag caccagcaaa tccacctacc gcagcaaggg gactaaaagc
    38761 tgaggtaaag actaaagcga ttgtgccagg gatttttccg atattaaaga aaataactgt
    38821 aagagttcct aagatataaa tgagggccat aaaaggaaca acagtagttg aaaccttaga
    38881 aatagacttg agtccaccaa agactgcaat cgctacaaag acagacaaga cgagagctgt
    38941 gatggctggc gaaatcgtcg ttgtattttg gatagattct gtaatcgagt tgacttgggt
    39001 gaaggttccg attcccaaga gagcaaccaa tactcctgct actgcaaaca aaacagcaag
    39061 tggtcgccac ttttctccca tccctagaag gatatagtgc atgggacctc ccgctactgc
    39121 accatggtcg tccttggtgc ggtatttgat ggccaagagt ccttccgcat acttggtagc
    39181 cattccaaag aaagccgcca tccacatcca aaatagagct cctggtccac caaccttgat
    39241 agccgtcgca actcctatga tatttcctgt tccaacagtt gatgccaagg ctgtacacag
    39301 agctgcaaaa ctggatacat caccatgtcc cttatcctgg ataaaaataa gctgaaaggc
    39361 cttgggcaga cgcaaaacct gcaagagtcc tagccgcatg gttaggtaaa tccctgttcc
    39421 gaccaataaa atcaagaggg gcggtcccca agcaaaagca tcgattgatt taagcaattc
    39481 taacatttcc ttctcctatc gtttcaaccc caaaagaaag agcacatgca agatacatgt
    39541 actctggaat gcttagataa atgctaaaaa gcggtctatc ctagctctgt ccttttacct
    39601 gagagtttga gcagttgcct gccttgcccc ttcggtgcct ttacggtctc tccagagttc
    39661 cgtccattta cagtcatgga aaatcaaacg attccccact tctattaaac ttcattcggt
    39721 gttggtattt aattgattct aattttacaa aaaatgttgg cttttgtcaa tgtgtttatt
    39781 agtaaaaatt agttcaacag tttttacttt ataaagtcca gaatactgct atcctttaaa
    39841 agtgacaata gtcgcaccac tgcctccagc attttgtggg gcatagccga aactcttgac
    39901 atgtttgttt ctttgcaagt atttggtaac tccttcacgg atgactcctg ttccgatacc
    39961 atggatgata tcaacttgag ccatattgtt aagcaaggct tggtcgatga aggtatctag
    40021 ctcattcatg gcttcttcat agcgcttgcc tcgaagatcc agtctagctt gaggtcctcg
    40081 cccagaagtt cgtttcacaa cattgacctg tttcttcttg actggttttt cttgctgggc
    40141 ttgaacaaga tcaaactctt tctcttccaa ggtcatctta atcaagccaa cttgggcttc
    40201 ccagcggccg tccttaagtt gactggtcaa ggtaccacgc tgaccataac tgagaaccac
    40261 gatatcatct cccacctttg gagctcgttt tttcttggcc ttttgaagga ccttgttttt
    40321 agacaagtcc actttttcag gagccaattt tttcaacttg gctttggctt caatgatttc
    40381 gtggggcttg agttgggatt tactgtggag atttttgaga atctggtcac tttcacttag
    40441 ggccatatcc acaatctcag cagcctgttc acgcgccttg ttaagctcgg tttccttttc
    40501 acgattaagc tcgttgtaga gtttttttag cacacggttc atcttgagat tttcttgctc
    40561 cacctcacgg atattgtcca agcgtttgcg gctttccagc gtctgctctt ctagttgctc
    40621 aatgatacga ttgacgtcat tgtcctgatc gatctgctga ctggcatctc ctacgataac
    40681 ttcagatagg cctagacgtt tggcaatttc aaaggcatta cttcggccag gaacaccctg
    40741 cataaagcga taggtcgggc gaagagttgc agtatcaaac tccatactgg cattttgcac
    40801 aaaggctgtc tcaataccgt aggccttgag ttctggatag tgggtcgtcg ccatggtctt
    40861 gatttgacgc aggcgaaggt cctccagaat agccatggca agggctgctc cctcttgggg
    40921 atcagtacca gcccccaact catccaaaag taagagtgaa tgttggttga ccttgccaag
    40981 aatatccacg atattggtca tatggctaga gaaggtagac aagctctgct caatagactg
    41041 ctcatctcca atatcagcaa agatttcttc aaaaatacca acacgacttc ccttgtctgc
    41101 taaaatcggc aatcctgact gggccatgac ctgtgtcaag cccagagttt tgagcatgat
    41161 ggtcttccca cctgtattgg gacctgtaat gacaatagct gttaaatctt gaccaaaata
    41221 gacatcattt gcgacggcat ttttgaccaa aggatggcag acatggagca gttgaatctc
    41281 ttgattttct gacagctgag gcacgactgc ttgtctttct tggataaatc gaaccttggc
    41341 acgaatcaag tccagatgac cgataatcca agcgtcatta gcaatctcag ccgcatgagg
    41401 gcggacacgc tcagaaattt cttggagaat gcgaagcatt tcatagcgct catctgctcg
    41461 cagactagca atttcttcgc tcagtttgac tacctcacgt ggttcgatat agacggtgtt
    41521 tccactagca gaaatatcat gaacgacacc tgcaatctta ttgcggtagg tgtttttgac
    41581 tggtaaaacc tgacggccat ttctgctagc aacaattcct tccgtcaaca tctgcgcttt
    41641 ttgcttgagc aagtcttgta aaacatcgcg tacctgactc tcgctatcat gtatttttcg
    41701 acggattcgc gccaattctt cactggcaaa attttcaatg aaacccgcat cattaaaggc
    41761 ctgaagattt ccttgtaatt gcggaaaatc atgtaatttc tcaaaccaaa gggctaattc
    41821 ttccaagctg acattttcca gattggcgta aaaactttga agttctcggc tggtaagaag
    41881 cacgcgtttc aagagtagga actcctcgat attgagatcc gctcccatct ccaacctctt
    41941 gcagactcct gcaatttcct tagttgagag aatagtaaaa tgcggttgct cgacgaaaag
    42001 agcctgcatt tctttcatct cagcaaaagc ctgtttgatt ttatctgctt tggcagtcgg
    42061 agccagctgt ctcaattgct ccaagccctg ctcggtcaac aaatgaggct caaacaaggc
    42121 cttgatctta tcgaactcta atgtttctaa tattttctta ttcatcttta tttccttgtc
    42181 tttgaatgtc taggtgtggt agctttttac attctgatag attcgagtca aatctgtaaa
    42241 caaagggcta ggaaaactcc tgcccttttt atccgattaa atttgtcacc cagatttgtt
    42301 tgagccaact ggttgttatc ggtatgctct ggatgatgtg ttttgcgacg atactctttt
    42361 caagaggatt ttgtataact gccatgggga tggtcgccaa gattgtcaag gccatttgca
    42421 agacaaataa ggtcaccaac atggacaaga tacctgctga aacttggaac aacttaccac
    42481 ccagtttttt gctaggaatc aagtgtaaga gaagaccaag caaacgacca atgctataga
    42541 caatcccaaa tacaagcaag tagccgatac ctgcataaaa gaccttatcc agctgaaaga
    42601 gttgatccga tgggaaaaag aaagtcccct gaccttcctg cgaatttgca taagggagca
    42661 ataaatggaa ttgctctcca agccccttat aaaactggcc agccataaaa gccgatgcca
    42721 tggctgaaat caggtaataa acctgtaaga gcaggcctct ccgatagccg atataaaatc
    42781 cccaaaccaa gaccaataga agaaggaatg aaatcataag gaatcctcaa tcttgctctg
    42841 ttcttgctta caagtcacaa gcttgtgacg gagttcttct agctcttgct ccttatcgtc
    42901 aaattcaatc tcacggctga gctgagttga taaacagttg actgccaaca aaagagcgat
    42961 tgtttcatca tctgcgctag gcatttgttc tttaattgct tggtattttt ctgtcgcaac
    43021 cttagcgatt tcctccataa aaaggttatc atgttcgctt gtcaaggtta acgatttttt
    43081 cccgaatgta aatttgaatc gatttagatt tgccataaaa ttcacctcac gatattatac
    43141 caaaattcgc taattttgtc agtttttaca aattttactg cttttgtggt acaatagaaa
    43201 ctatggcaag tatcacactc acaccaagcg aaaaggatat tcaggctttt cttgaacact
    43261 atcaaaccag tctggctcct agcaagaatc cctatatccg ctactttttg aaactacctc
    43321 aagcaacggt ttctatctat acttctggaa aaatcttgct tcagggtgaa ggggctgaaa
    43381 aatacgccag tttctttggc tatcaagctg tagagcaaac cagcggacaa aatcttcctt
    43441 taattgggac agatgaggtg ggaaatggtt cctactttgg tgggcttgca gttgtggcta
    43501 cctttgtcac acctgaccag cacgactttt tacgaaaact cggtgtgggg gattctaaga
    43561 ctctgaccga ccaaaagatc cgtcagatta ctcctattct caaggaaaaa attcagcacc
    43621 aggcactcct tctctcaccc agcaagtaca acgaggtcat cggagaccgc tacaacgctg
    43681 tttcggttaa ggttgccctc cataatcagg ctatctatct cctccttcaa aaaggtgttc
    43741 agcctgagaa aattgtgatt gatgccttta ccagtgctaa aaattatgac aagtacttgg
    43801 cacaagaggc caatcgtttc agcaatccta tcagcttaga agaaaaggct gagggcaaat
    43861 acttgtctgt cgcagtttct tctgtcattg cgcgtgatct ctttctggaa aatcttgaaa
    43921 atttgggacg agaactgggt tatcagctcc caagtggagc tggaacggct tctgacaagg
    43981 tggctagcca gattttgcaa gcctatggta tgcagggact cagcttctgc gccaaattgc
    44041 actttaaaaa cactgaaaaa gcgaaaaaac gcttagaaag gtaagttatg aattcattta
    44101 aaaatttctt aaaagagtgg ggattgttcc tcctaattct gtcattacta gctttaagtc
    44161 gtatcttttt ttggagcaat gttcgcgtag aaggacattc catggatccg accctagcgg
    44221 atggcgaaat tctcttcgtt gtaaagcacc tccctattga ccgttttgat atcgtggtgg
    44281 cccatgagga agatggcaat aaggacatcg tcaaacgcgt gattggaatg cctggcgaca
    44341 ccattcgtta cgaaaatgat aaactctaca tcaatgacaa agaaacggac gagccttatc
    44401 tagcagacta tatcaaacgc ttcaaggatg acaaactcca aagcacttac tcaggcaagg
    44461 gctttgaagg aaataaagga actttcttta gaagtatcgc tcaaaaagcc caagccttca
    44521 cagttgatgt caactacaac accaacttta gctttactgt tccagaagga gaataccttc
    44581 tcctcggaga tgaccgcttg gtttcgagcg acagccgcca cgtaggtacc ttcaaagcaa
    44641 aagatatcac aggggaagct aaattccgct tctggccaat cacccgtatc ggaacatttt
    44701 aagaaaccta agaggccgag aatcaccaat ctcagcctct tcttctatcg tgagaaaatg
    44761 attggtaact atctaaactt accagaacag aaacacctca actctcacct attcatgcaa
    44821 aggaatttta tggaagttta tttttcagga actattgaac ggattatttt tgaaaatccc
    44881 agcaattttt atcgcatcct cctcctagaa atcgacgata cggacgcaga ggattttgat
    44941 gattttgaaa tcattgtcac aggaaccatg gctgatgtaa ttgagggcga agactatact
    45001 ttttgggggc aaattgtcca gcactccaag tatggagaac aactgcaaat cagtcgttat
    45061 gatcgcgcaa aaccaactag taagggcttg gtcaagtact tttcaagtag ccatttcaag
    45121 gggattggtc tcaagacagc tcagaaaatc gtggatacct atggcgaaaa taccattgac
    45181 gaaattttgc aacacccaga aaagttagaa ggcatcgcag gactctctgc caaaaatcgc
    45241 gaggctttcg tctccactct ccgtctcaac tacggaacag agatggtttt ggccaaacta
    45301 gccaactacg gcattcccaa caaactagcc tttcagattc aagactttta caaggaagaa
    45361 acccttgatg tggttgaaaa ttatccctac cagctggttg aggatatcaa gggtttgggc
    45421 tttaccattg ctgaccaact agctgaggaa ctaggcatcg aaagtcaggc tcctgaacgc
    45481 ttccgcgccg gtctagttca cagtcttttt caggcctgta tggaaacagg agacacctat
    45541 gttgaagcac gggatttgct ggaacaaacc cttactctcc ttgagtcttc ccgtcccgtg
    45601 gaactagacc ccagccaagt tgcccaagag ctctcctacc tgatcgaaga agacaaggtt
    45661 cagcagattg ataccaagat ctttgacaac agcctctttt tcgctgagga aggtatccgc
    45721 agtcacttga ttcgtatcct tgaaaaagga aaacagaaga gccaagattt agaaactatt
    45781 caaaagcata tcactactgt cgagcaagaa ctggggattg agtatgataa cattcaaaaa
    45841 caagctattt gtgacgctat ccagaacaag gtctttatcc tgacaggtgg acctggtact
    45901 ggtaagacaa ctgttatcaa tggaatcatc gctgtttacg ccctgttaga gggacttgac
    45961 ctcaggaaga aaagcaacct gcccattctt cttgctgctc caactggtcg agctgctcgt
    46021 cgcatgaatg aattgacagg tttgcctagc gcgaccatac atcgccactt gggaatgaca
    46081 ggtgacgatg ataccagtca tctggaagat tacctagatg ctgactttat catcgtggat
    46141 gaattctcta tggtagatac ttggctggcc aatcaactct tctccaatat ctcttctaac
    46201 agtaagatcc tcatcgtagg tgacagtgat cagctacctt ctgtcagtcc tggacaggtt
    46261 ctagcggatc tgcttcatat tcctttgatt cctcagactc gcttggaaaa aatttatcga
    46321 caaagcaaag aatcaaccat cgtcacccta gctagtcaga ttcgacaggg catcttgcca
    46381 gctgatttca cccaaaaaaa agctgaccgt tcctactttg aaattgctag tggccatatt
    46441 cctgccacca ttgaaaaaat cttaggtgcc gccctcagaa atggtattcc tgcccgtgat
    46501 atccaagttc tggctcctat gtaccgaggg acggcaggga ttgatgctat caatcagctc
    46561 atgcaagacc tgctcaatcc cccacaaaaa gatcaactca gttttgaagt tcctcagtgc
    46621 cactatcgta agagagacaa ggtcattcat ttggttaacg atgctgaaat caatgtcttt
    46681 aatggagatt taggagctat cacagacctg attcctggta aatacaccga atcgaaacaa
    46741 gacgagattg tcattgattt tgatggtaat gaagtctctt acccccgtaa cgaatggtac
    46801 aagattcgct tggcctatgc catgagtatt cataagtctc agggaagtga gttcccagtt
    46861 gtcatcctac cgattactag tgctagccga cgtatgctgg agcgaaatct catctacaca
    46921 gccattacac gtgccaaaag caaactcatc ttactaggcg aattacaagc cttcgactat
    46981 gctacccaac acatcggaac tgcccgaaaa acctatctga ttgaacgctt cagtgatcta
    47041 ctggagaatg ttgaagaaaa gcaacaagct gtctctgaaa cagtcacatc aagtgcctct
    47101 gaacaatcct acatcctaac cgaagaaaac tgggacagca ttccagccat gattgggatt
    47161 acagacacag acctcaaaga gatttttgga aaatagtaca tcagaaaacc caccaattca
    47221 ggtgggtttt ctgtttatta agattatttt actgttgctg tgcttgtgat caattcaaca
    47281 gcttttttga tagtgatatc atgtttcaac atgtcagctg aaagcaagtt ttgaacttgt
    47341 gcaacttcca tgttgtagtc tgctgccaat tgctcaactt ctttttggat ttcttcttct
    47401 gaagcatcaa atccttcagc tttggcaact gcttcgataa caaggttagt cttagtacgt
    47461 gactcagctt ctgcttggta ttggttgtga aggtcttctt gagtagttcc agtgatttgg
    47521 aagtacatgt cagggttgat cccttgacgt tgcaagttcc caaggaattc atttactgaa
    47581 cggtgaactt cttcatggat catttcttct ggaagttcta cgatttcagc gttttctaca
    47641 gctgtatcaa ttgctgcacc ttcaactgca tctttgtaag cttcttcttt agcagtagcc
    47701 aattctttgc ggtatttttc tttcaagtca gcaagtgttt caacttcttc atcaatgtct
    47761 tttgcaagtt catcgtcaag agctggaact tctttagctt ttacttcgtg gatagttgtc
    47821 acgaatttag cttctttacc tgcaaggtct tctgcttggt agtcttctgg gaatgttacg
    47881 ataacatcaa cggtttcgcc agctgagtga cctaccaatt ggtcttcgaa accagggatg
    47941 aattgacctg aaccaagtcc aagtgagaag ttttcacctt ttccaccgtc aaattcaaca
    48001 ccgtcgatag aaccaacgaa gtcgatcaca acagtgtcgc cgttttcagc agcagcttcc
    48061 ttgataacca attcagccag attgttgcgt tcgcgttcga tacgctcttc aacatcagcg
    48121 tcagttactt ctttttctac atcaactgat acttcaaggt ttttgtagtc acccaatttt
    48181 acttcaggtt ttgtaacgac ttcagcagtg ataacccagt cttgaccttt ttccattgaa
    48241 gttacgtcaa tttttggttg ggcaaccact tcaagaccag cttcttttac agctgcttca
    48301 taagcgtttg gcaaaagagc gttcataacg tcttggtaaa gtgattcttc accaaatttt
    48361 ttatcgaaga taggacgtgg aaggtgacct ttacggaaac ctggaacatt aagagatttc
    48421 ttcactgact tgaagacacg gtccaattct ggtttgattt ggtcttgaga gatagtgaaa
    48481 gtcaagacac cacggtttgt ttctttgttt tcaaatgata cagacattct gtcatttctc
    48541 cttaaaattt tttaaataca gtctattata acattttcta taaataaaat ctagactaat
    48601 gcagacaatt atagacaaca agcctttttc ctaactaaaa cactcataaa gtatagacaa
    48661 ttttagacta ctttggatat cttttggtta gtcattttcc aaaactaatt tatctaattt
    48721 atctaatttt tcagttatat aatagattga aactagaata gtacacctct acttctaaaa
    48781 catttttaga aatcgatttg actatcctga tcgatttgtc ctgttcttgt ttcatttcac
    48841 tatatagatc gcattcgaaa gaattcgttc caaaattgct tggttcgttc ttctcttgga
    48901 cgactaaaga attgatgggc attatttttt tcaacaattt tcccactgtc cataaaaata
    48961 acatgatggg ctacatctct agcaaaaact atctcataaa gctgatcaaa aactcaatct
    49021 gaggagaaaa tccaataagg ctttccataa taaaggacat cctatcaaga tttttgaaca
    49081 cccgataggc tgcctttttc cgattttgaa gactttttgt ccagcttctt ttaccttata
    49141 aataacaaca aaaatcaaag acaagctaga aagattaccg cagataactc aaacagtgtt
    49201 ttgaggttgc agataagact gacggagtca gctcaaagca ctgctttgag gttgtagata
    49261 gaactgacga agtcagtaac atatgcctaa gacaaagcga tgctaacctg atttgaagag
    49321 attttcgaaa aatattaaat atactctaca atttgatcaa tcaattcttg gtcgtctaaa
    49381 cctgtaactt gtataacaac atctttgact gattgtttag ccaacaattc acctaatcga
    49441 atactttctt catcatttac atcgcgatag tcaaaggcat agccaactgt tttaagtagg
    49501 tttttatatg acaaactgag ttctttcaat tcacgtatcg gccggatgaa tcgttcatta
    49561 tagcctaatt ttcggattgg agtacgagct acgcgactaa cctcgtccac tatgaaaggg
    49621 ttttcaaacc gttctataat gactttgtga taattctcca attctttttt atcaaagttc
    49681 catttggcaa tcaagagact ccgaatttca gctaatacag attcaatccg agatttaata
    49741 ttaggatttt gaagagcttc caaaattgtc ttggcaccat aatgcgcacc aatgtaagct
    49801 gaagttgcat gtccagaatt gactgaaaaa agttttcgct caataaaggg ttctaaatct
    49861 tcttcataat gcacatcttt tagacgtaaa tctggatttt taagacgctt ggtttccacg
    49921 acccattcat taaagggctc gaccacaaca aaaagggaat cttcgtgact ttgtgctgga
    49981 acaatcctgt ctactgcagc atttggaaaa cctatgtagt tatcagcaaa tgtcaaacct
    50041 tccggactta aatatttctt gacttcttga taaagaaatt gagacccgcc aatcatattt
    50101 tcacaggcca taacatccaa tgcctgtgta tttcctgcaa ctcggcgagc ttcgattcct
    50161 ttggctagaa gttcggcgat aaaagggagt atattaggtc cgattgcagt agtaataata
    50221 tccgtccttt gaatcgcttc aatgacttgc tcaggatgtt ctttgctatt aatgccagcc
    50281 acattagtta cttctatacg agactgtcct ttctgtgcaa tttcaatttc atacttgccc
    50341 ttttcattta gagcatgaat tatctgatta ttgacatcca caaaatcaat atggaaacca
    50401 tttttaaata gaatttcacc tataaaacca cgaccgatat taccggcacc aaaatgaaca
    50461 gaatgtttca ttcaatttct ccttttccta tttgagggac atatatacta gatgacaaat
    50521 gacgaaattc aattattcaa cagcatcaaa taagcgcaat acttcctctt ttgactgagc
    50581 atctgctagt ttaagaacat tatctacatc tgcacagaag acagaaattt tctgaataat
    50641 ttctaagtgt tcattaccaa taccagcaat accaaaaaga accgttgcca cttgagggtt
    50701 agatacattc ccaaaatcaa cccctctagg gacttgaacg actgtaatac cagacttgag
    50761 gacatccttt tttgctgcat ctgttccatg cggtatggcg ataaagttac ccatgtaaac
    50821 agataactct ttatctcgct caatcatggc ttcaatatag tcttcattaa catatccacc
    50881 ctcataaaga acttgcccac aataacaaat agcttcctcc ttgttagaaa attgtttatt
    50941 aagcttaatc aaatgttttt caagtttcat attagttctc caatttctta attttttcgt
    51001 taaaaatagt atttagcatc tgataaataa tggattgatt tcccgtcttg taaatctctg
    51061 tataaagatg attttcaata atcgactgac taatagctgt cattaaatct ctagcttcct
    51121 cgctagcttc tttagacatt agcattagca gacacctttt gacctcttct tcctctcgtt
    51181 tcattgacaa tgcggagata ggtagtttga gttcaaacat agtaaaacta tttgttgtta
    51241 ctttgctaga ctgactatgt aaaagcacca gaccagtatt aggaatagcc ataggactat
    51301 tctggaagtg agataacaat tttcttgtta ggtaatctct gtcactcaca ttcttctgat
    51361 attggatgat ttgttctacc gtgtgctcaa atgattgatt attctccaat tgaaccaact
    51421 cgaattgact caaaagctga ctactagata ttaaataatc ttgcaagtca taacttttct
    51481 ctggagcgat agcatcacgc gcgacaattg tacgatgtgc ctgtacatac tgaagtcgtt
    51541 cctgtaattc aagcaattct ttgacggttg gaaaactaga aattacatcg atttcctgat
    51601 tagtcagcgg cttggtagat aaaatataat catactgact gagatcaata ctgtggtaat
    51661 ctactagaga ctgaatatct atcaactcta caaaaggagc aacactctta attttactga
    51721 ctaataaatc tctagtgacc cgacgttcat ccgttaaaag caaaacacgg actggataaa
    51781 tctctggact acggcctaag ctagagataa aatgtagggc aatcatgcca tactcatact
    51841 ctgtatgaag atatttcgga aaaatatcat tcactaaaag actgatgact gtataaagaa
    51901 atttattcct ttcaactaaa atctggacag attctggcaa attttcaccc tgaaaaagga
    51961 tagggacgcc taaactgagc cgaatatgat ggaaaagaaa attgaataaa accttgtcct
    52021 taaaaaagtc aattttgata tacatggaaa ccgtatcaat cagatttgaa atattgtaga
    52081 aaaattcacc atcaaatttc tccgtaaaga gcggattgtc ctgacgttta atgattaatt
    52141 catccaagat gctcgcaaaa tagataattt cctgaatact ataaaattgt gcagtctgct
    52201 tagagtaagc ttgaaaaatt ttttgagaaa tttccaaagc ctgcttacta gtattaggtg
    52261 aattttcaat gttttgctcc tgacctataa gagataacaa gattgcaaaa aacatcttca
    52321 tcctagcatc catatctgga aaacctgaca gttgcttatt aacaatctga ctggccagcc
    52381 tagttctatc tgcttctaaa atatcaaagc tcccaaaatt accggttgaa aaatctgcta
    52441 ctgagataca gtttgtcagt aaaatagcca aaaatcttct cttaccaact gaatcaccag
    52501 aaatccgata acctttttgt cgttcaattt tcagatcaaa gtctaaaaga cgcttatcaa
    52561 tatctgaaat atcctgaata atagttacat tactgacttt cgtgcactct tgcaatgctt
    52621 cattggtgac aaaaccgctc tcagtcagaa ggcgataggt aatcaactct tgtctttctt
    52681 ggggactata ctcaactaac acttcaagtt ctgtcggcaa atcatccaac tctccagtca
    52741 aaatatagta tttcccatgc ttcgttattt cgattccata ttgctccatg ctatctgtca
    52801 aatctgataa agttcgataa attgttctag atgaaacctg taagatttca gtcatatctt
    52861 gcattgaaag cttccctaca tgtaggaaag ccttcaataa ttgttcttct cgtttggtta
    52921 atagcattcg taatttagaa acctctagtt ctatttgtac attctagcag ccattttgtc
    52981 atattctggt gttgttacta aactatccac aataagaaat tgagaattcg gtgctgcttg
    53041 ctgcacttct gcctgtaaag aaatagttgt tacaatcatt atatttttag aattaaattc
    53101 acctaattct gaaattttgg cagtagaaac tggaatacga atattcttgt ttctaaagat
    53161 agcccgaatc gtttcacagc ccatagttgc agttccctgt gctttaccat aagcaactac
    53221 tacagcatca atagggttaa ggtcaatttg ctgactatct actggtgctg aagttggtat
    53281 atctccttca atttctgcta ttggagaagc tcctgttaat gaagctacaa tttcatcata
    53341 acgaggggac gctaagaaat tatcaacaga aacatgaata gcacttggac tcttgtcttt
    53401 agctcttggt gtcagttctt cctgagtaac aattaatgtt tttggtgtat caagcaaatt
    53461 tgagattgcc tgattagata ctggaatctc tagacctgct tttttaacct tatctcgaag
    53521 aatactagct cccatagcag agcttcccat accagcatcg caggcgaaaa tgattttttc
    53581 cactgagtct gtcgaaacaa ctgcatcaac agaagttgat actaactgac ctttagactg
    53641 agccttagct gcttgggtag ccgcctgagc agcttcgagc gaatcctcag ttgacttgtc
    53701 tgcatgaaga ataagggctg ctacaaggaa agaaacaact gctgctacta aaacacctag
    53761 aagaacattt atatggggcc aaacaccttt tggcgccgta gccataatcg caataataga
    53821 acctggtgaa gctggagatt taagaccagc gtctaagagt tgaaaagtaa aagttccaga
    53881 gatacctccc gccatagcag ctaaaaatag agtaggcttc atcataacat aaggaaagta
    53941 aatttcatga atccctccga agaaatgaat aaccattgcc ccccaagaag aagatttagc
    54001 agaaccttta ccgaatacag cataagctaa tagaattccc aggcctggtc caggattagc
    54061 ttccaatagg aagagaattg acttaccagc ttgagctacc tgttctactc ccagaggagt
    54121 aaaaatgcca tgattgaggg cattattgag gaaaaggact ttagccggtt cgatgataat
    54181 attagccata ggaaggaggc gagcattgac aatagcctca acaccattcc caacagctcc
    54241 agtaagagtc gatacgactg gaccgattgc atagaaagcc aaaagcaata atgcaaaacc
    54301 aacgagatca gctgagaagt tattaactaa catttcaaat ccgggacgaa ttttttcttg
    54361 gaacttctca tcaaatttct tgatagtcca tcctcccagt gggcccatta ccatagctcc
    54421 gataaacata ggaacactag aacctgtgat tgcaccaaca gtagcaatag atcctacaac
    54481 ggcaccacgt tggccatgga tcatatatcc acctgtgtaa ccaatcagga ttggcaataa
    54541 atacgttaac ataggaccaa caacagtagc taactgttca tttggcagat aaccatcagc
    54601 gataaagagg gcagtcaata ctccacaagc aataaatact ccaatattgg gcataaccat
    54661 atttgaaagc gatgtcccta gtttttgaac cctgactttc aatgatactt tttcttccat
    54721 tagatcatcc tccttttctt aaaactagta tatacaaagt taaaaacctt taaaactaaa
    54781 gttttgtcac agattttgtg tcaaaacatt acttttgatg aggctgggca aaaaggctta
    54841 aaaattataa aacgcatcat atcaggtgta catgaactac accccaaaag ttagacagaa
    54901 aaaatctaac ttttggg
//
LOCUS       DAVHSO010000005        52753 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.005, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000005 DAVHSO010000000
VERSION     DAVHSO010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 52753)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52753)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52753
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.005"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            389..1567
                     /locus_tag="VVR18_000314"
     CDS             389..1567
                     /locus_tag="VVR18_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6031913.1"
                     /translation="MSNSFVKLLVSQLFANLADIFFRVTIIANIYIISKSVIATSLVP
                     ILIGISSFVASLLVPLVTKRLALNRVLSLSQFGKTILLAILVGMFTVMQSVAPLVTYL
                     FVVAISILDGFAAPVSYAIVPRYATDLGKANSALSMTGEAVQLIGWGLGGLLFATIGL
                     LPTTFIILVLYIISSFLMLFLPNAEVEVLESETNLEILLKGWKLVARNPRLRLFVSAN
                     LLEIFSNTIWVSSIILVFVTELLNKTESYWGYSNTAYSIGIIISGLIAFRLSEKFLAA
                     KWESILFPLVAMAIVTLTILYFPNAQMFLLFSALVGMLSQLKEVPESVFLQETVEENH
                     LVNVYSVLEVISTLAFSVFVLLMSYITESFGISISFWLSAICLMIEAILIYIRRDYFK
                     "
     gene            1891..2022
                     /locus_tag="VVR18_000315"
     CDS             1891..2022
                     /locus_tag="VVR18_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="teichoic acid D-Ala incorporation-associated
                     protein DltX"
                     /protein_id="HEU6031914.1"
                     /translation="MKQRKELYLFLGRTALYFLIFLGLLYFFSYLGQGQGSFIYNEF"
     gene            2043..3593
                     /gene="dltA"
                     /locus_tag="VVR18_000316"
     CDS             2043..3593
                     /gene="dltA"
                     /locus_tag="VVR18_000316"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltA"
                     /protein_id="HEU6031915.1"
                     /translation="MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDS
                     LAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEV
                     AEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
                     GQPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGT
                     LFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDG
                     EELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADS
                     PTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGT
                     MTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLL
                     AYVILKDSVREQFERDIDITKAIKEDLTDIMMSYMIPSKFLYRDSLPLTPNGKIDIKG
                     LINEVNKR"
     gene            3590..4834
                     /gene="dltB"
                     /locus_tag="VVR18_000317"
     CDS             3590..4834
                     /gene="dltB"
                     /locus_tag="VVR18_000317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HEU6031916.1"
                     /translation="MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYE
                     VLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLFYKHYRKSKDGKWVFYLVSFLSL
                     LPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIIIELRDGVIKDFTLWEFLRFLLFM
                     PTFSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMRGFLYKFILAHVLGETLLP
                     PLKNLALQSGGFFNLYALAVMYTFGLELFFDFAGYSMFALAISNLMGIRSPINFNKPF
                     LSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRNVTSSMAYIVNMLIMGF
                     WHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVT
                     FHVVMLSFLIFSGFLNNLWFKK"
     gene            4848..5087
                     /gene="dltC"
                     /locus_tag="VVR18_000318"
     CDS             4848..5087
                     /gene="dltC"
                     /locus_tag="VVR18_000318"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005591431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HEU6031917.1"
                     /translation="MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVE
                     IENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA"
     gene            5080..6348
                     /gene="dltD"
                     /locus_tag="VVR18_000319"
     CDS             5080..6348
                     /gene="dltD"
                     /locus_tag="VVR18_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HEU6031918.1"
                     /translation="MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVAT
                     TIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFDGAHPAVLAEKYNRSYRPYLLGQG
                     GAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTSFLKHQ
                     SGDQASQYAATRLLQQFPNVAMKDLVQKLASKGELSTADNEMIELLARFNERQASFFG
                     QFSVRGYVNYDKHVAKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQI
                     KKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSKSKVNPIFIIPPVNKKWMDYAGLRE
                     DMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVDPFLS
                     NPTPAPTYHLNERFFSKDWATYDGDVKEFQ"
     gene            6503..6943
                     /gene="adcR"
                     /locus_tag="VVR18_000320"
     CDS             6503..6943
                     /gene="adcR"
                     /locus_tag="VVR18_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent transcriptional regulator AdcR"
                     /protein_id="HEU6031919.1"
                     /translation="MRQLAKDINAFLNEVILQAENQHEILIGHCTSEVALTNTQEHIL
                     MLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLAR
                     PIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEIK"
     gene            6943..7647
                     /locus_tag="VVR18_000321"
     CDS             6943..7647
                     /locus_tag="VVR18_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEU6031920.1"
                     /translation="MRYITVEDLSFYYDKEPVLEHINYCVDSGEFVTLTGENGAAKTT
                     LIKASLGILQPRIGKVAISKTNTQGKKLRIAYLPQQIASFNAGFPSTVYEFVKSGRYP
                     RKGWFRRLNAHDEEHIKASLDSVGMWEHRDKRLGSLSGGQKQRAVIARMFASDPDVFI
                     LDEPTTGMDAGSKNEFYELMHHSAHHHGKAVLMITHDPEEVKDYADRNIHLVRNQDSP
                     WRCFNVHENGQEVGHA"
     gene            7640..8446
                     /locus_tag="VVR18_000322"
     CDS             7640..8446
                     /locus_tag="VVR18_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEU6031921.1"
                     /translation="MLSLLSYDFIQRAFLAVIAMSLFSPVLGTFLILRRQSLMSDTLS
                     HVSLSGVAFGLVLGISPTVSTIAIVLIAAVFLEYLRTVYKSFMEIGTAILMSTGLAVS
                     LIVMSKGKSSSSMSLDQYLFGSIVTISEEQVISLFVIAVVVLILTFLFLRPMYILTFD
                     EDTAFVDGLPVRTMSILFNMVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKNFKS
                     VMLLASAIGFLGMVAGLYISYYAETPASASITIIFVTVFILISLVRRFIK"
     gene            8456..9961
                     /gene="adcA"
                     /locus_tag="VVR18_000323"
     CDS             8456..9961
                     /gene="adcA"
                     /locus_tag="VVR18_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding
                     lipoprotein AdcA"
                     /protein_id="HEU6031922.1"
                     /translation="MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQ
                     VAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKK
                     KVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLS
                     ADYPDKKETFEKNAAAYIEKLQALDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQ
                     VAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLN
                     PLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAA
                     VKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYHTDVTK
                     INITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFS
                     DHNIAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYPDNLSGQEIAQEMLAH"
     gene            complement(11089..11862)
                     /locus_tag="VVR18_000324"
     CDS             complement(11089..11862)
                     /locus_tag="VVR18_000324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU6031923.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLE
                     NQGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCVYLDSST
                     TVYELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKE
                     NSLLDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNIIDKAHETILLIDSSKFYKTG
                     FFKINPLSKYTTFISDTVPDQKLLDAVELFDGEWVSDIQ"
     gene            12038..13441
                     /locus_tag="VVR18_000325"
     CDS             12038..13441
                     /locus_tag="VVR18_000325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhamnulokinase"
                     /protein_id="HEU6031924.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGH
                     LSWDIDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLSQPVHYRDERT
                     KGVLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFN
                     YLLTGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDSSLLPEIVSEGNVLGRIKKE
                     YGLGDIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGF
                     TNEVGKDGEITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTE
                     STEFATESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKV
                     YKRIYVIGGGARASYFNQMIADRTGKEVLTGSTEGTAVGNIVVQLLSQGKINEDTELK
                     DIMTNIADTKYYYPQLS"
     gene            13471..14763
                     /locus_tag="VVR18_000326"
     CDS             13471..14763
                     /locus_tag="VVR18_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6031925.1"
                     /translation="MNKKSLLKCAVIGLVATFGLAACGTSKDASGGSSSGKEVLEFYH
                     GYHHSEDEWPVAKTMRDLYDKFAEEHKDSGVEFKPTPVNGDLKDIMNNKVASGEFPDV
                     IDLAGNAVSLAAIEQKLVLDLKPYIDSNKLEKNVGLNYKQNQKDGKIYTVHEQLFTMG
                     LWYNKDIFAKAGAKTPDQWNTWDDFTQAMASIRKQDGVYAFGAGEPSIRLFNTVLGTT
                     ENGRKLLDKPLTKEGIESKEFADALKMVMKEIQANGSKNAGGDANAYSKDFQEGKSAV
                     FFNGVWASGEMSKNPSLAPGIYPAGVAISSSGGGITISSKMSEAKQKLALEFLKYMTS
                     DDVQKVIFEKVGANPSNENVNVKELSEKSSEATTKILGQAITQVKNAKAVVPTVSDVW
                     GGDVHTAIINALTESAAENVDVDQKVKSTQDVLKSLIG"
     gene            14851..15780
                     /locus_tag="VVR18_000327"
     CDS             14851..15780
                     /locus_tag="VVR18_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000057514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6031926.1"
                     /translation="MAQKIMSLQNRKNQKRRFIFLFLLPTLICFFLFYFYSVVTIFLT
                     SFAKWDYTNLNTPEFLGFDKLFENYRYVFKEYPFFTEALINSVRWAVIGVIIQVPLAV
                     SVAITLSKKLKGWKISRNLYIVPSIISSAAMGLIFLQIYNPNYGVVNQIIHLFNPSFK
                     DSVLLTPGLNIVAMTGAYIFFAGASTIMILGQIFAIPEEVQEAAILDNITGWRKEWYI
                     TIPMIKGTIKTVSIMAATSGFLLYNEVFFLTNGAAGTKSISFVIRELAVASSRTQYAR
                     ANTIGVIQILGGMLIIVCINILFRERKRLKGGK"
     gene            15783..16622
                     /locus_tag="VVR18_000328"
     CDS             15783..16622
                     /locus_tag="VVR18_000328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU6031927.1"
                     /translation="MNTHINGISKKGKVLIYGYMLLTILISIFPIAWIFLSSLKADPM
                     KNPGISLPTDFTLEGYINVFTKLHVFTYFWNSFKVVSISVIISIVMISMSSYVIARME
                     FRGKKLVTSMLYSTLFIPATAMTFPVYRLVNELGIYNTPVALILVYSCSGIAMSFFII
                     KNYFEIIPKELEEAAEIDGATYAQTFWKVMLPIARPGILTAAVLAFINNWNEYYWASM
                     LVIDKNELTVPALLGQFTTSFNTNYNGLFSAIVVIVLPPIILFAFTSKYFIEALGGGA
                     VKG"
     gene            16619..17938
                     /locus_tag="VVR18_000329"
     CDS             16619..17938
                     /locus_tag="VVR18_000329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000683274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HEU6031928.1"
                     /translation="MKHTLETINSRTQWFREARFGMFIHWGLYSIPGKGEWIRSHQKL
                     SIEDYEPYFRAFDPKEYNPREWAKQAKAAGMKYMVLTAKHHDGFCLFDSKFTDYKATN
                     TPAGRDLVKEFVDAVRAEGLKVGLYFSLIDWHHPDFPKYADLNHPMRGNEAYRDEKIN
                     FDSYLEYLHNQVKEIVTGYGQIDILWFDYSYEDMVGEKWGASKLIDMVRHYQPNVIVD
                     NRLETSGEGFGSIVTDEITSYAGDFVSPEQIVPHEGIRNFKGEPVPWELCLTMNNNWA
                     YNPTDYLYKSSQTLIRKLVECVSKNGNMILNVGPDALGRINDSSKKILDNFHRWMSRN
                     GEAIYGCSGDENLPKPDWGYYTRNGNTVYAHVFEQPIGPLALLGISKENVKRMSFLHD
                     GSEVKISESWTTNAYKGICFAQFGEVPHFTYPLPDLIDSVIKIELRE"
     gene            17944..19815
                     /locus_tag="VVR18_000330"
     CDS             17944..19815
                     /locus_tag="VVR18_000330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-N-acetylgalactosaminidase"
                     /protein_id="HEU6031929.1"
                     /translation="MKIENKNVRRNFFWGDGRFYTTDIVNKRAGVMIKNVSKEEFTIT
                     LENGIRLSSNHFSAIVREEGDTRIQVSFVCPSIRLRLIFESRDDVLSKQLVLESSTEV
                     IKSVEVESFEFETEDNIFYPKRQDCIKEMANFSGYYVELGQPVYANSLFLGMEFPMSE
                     NKVDGRHYVSRYYLGTVVNQEKSLWSCIIGGACSYKKEEIQEAFFEYVEGIAQPSYFR
                     KQYNSWYDHMTDITEEGILKSFSEIRDGFENHGVHLDAYVVDDGWTNYQSVWEFNHKF
                     PNGLRNIKHLVNGFGSSLGLWIGPRGGYNGTEIIMSDWLEAHPELNIGSKNLISNDVN
                     VADFNYLNQMKKKMLEYQKEFDISYWKIDGWLLQPDKPDKSGPHGMYTMTAVYEFLIQ
                     LLIDLRKERGGKDCWLNLTSYVNPSPWFLQWVNSLWIQISQDVGFTENAGNDINRMIT
                     YRDSQYQEFLEKREIQLPMWSLYNHEPIYAVSANTWYMDHQMFASIPDFEAYLLFIST
                     RGNAFWEFHYSFDMFDEERWKANARAVKWIEENYQTLKYSKKIGGSPEKFEIYGYKCH
                     NQKTSTEILSLRNPAQIKQKIKIENLSIENFTRVIGDFTIQEDEIELAPYSIVILKK"
     gene            19837..22053
                     /locus_tag="VVR18_000331"
     CDS             19837..22053
                     /locus_tag="VVR18_000331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="HEU6031930.1"
                     /translation="MTIYINKDETVFHLAMKDSSYIFRILENGELQHLHFGKRIHVKE
                     NYNQLMAYEKRGFEVSFSEEFEDIQQSMIQNEYSSYGKGDFRHPAFQVQGMNGSRITT
                     LKYQGFELEKGKNRLNSLPSTFDDIGQCAETLTIILTDSILDLTVRLNYTIFPEYNVL
                     VRNTEFLNNSNNKLTLLKAMSLQLDLPDSQYDFIQFSGAWLRERQLYRTSLRPGIQAI
                     DSLRYSSSPQQNPFFMLSRRETTEHSGEVYGFNFIYSGNFQNMIEVDHFDTARVTVGI
                     NPVEFRFLLNPAESFVTPEAIVIYSDQGMNQMSQQLSDFYRHHLVNPNFSQASRPIIL
                     NSWETFYFDLSTEKILDLAKAAKDLGIELFVLDDGWFGHRKDDKSSLGDWVTDRSRLP
                     EGIGFLADEIHKIGLQFGLWFEPEMISIDSDLYKNHADWTIHLLDREKSVGRNQYVLD
                     LTRQEVVDYLFDSISKIIIKTNLDYIKWDMNRHITDIYSIELDSEQQMEFGHRYILGL
                     YQLLDRLITKFPSVLFESCSSGGGRFDLGLMYYAPQAWTSDDTDPIERLKIQHGTSYG
                     YSPSMMTAHVSISPNEQSGRQTSLDTRTNVAYFSSFGYELDVTRLSVEEKEQVREQIQ
                     FYKKYRSLFQYGDFYRINSPFSCDSASWQVVSKDKCQSILLYAQLNSKLNPGYTRVYF
                     SGLDKDKCYSVSGFDEFFYGDELMNAGIKVSLSNLALCVPEYLTKLFVIEEVVCKY"
     gene            22064..25075
                     /locus_tag="VVR18_000332"
     CDS             22064..25075
                     /locus_tag="VVR18_000332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NPCBM/NEW2 domain-containing protein"
                     /protein_id="HEU6031931.1"
                     /translation="MESKKIAKQILIATAVLTSFLGSNLVYADVVQSNSNNRASTETA
                     RVTGNNLEKLITKGKEIDKEMTYLSDMDWSSATHGDIDKTKTVQKDAPFTTGNKGEHT
                     KISLLTSDNKVKYFDKGIGTVADSPSVISYDISGQGFEKFETYIGIDQSANSSRSDHA
                     VVDKIEIDGKVVYSSSVTNPEGFRYNTQAQFISVTIPQNAKKISLKSFAGEHTWGDEV
                     VFADAKLIKTVSTQTITPDLLNKGINGGVYLSDLEWVDATHGDDDKSKTVQKDKPFTP
                     GNNGSNNKIKLLIDGKEVEFNKGLGTVASNPSSIKYDVSGANVTRFISYVGIDRSANH
                     LNSDYADIQKFEVVADGKVIYSSDSKYPKGIKYDTSAFLVDVEIPKDTQTIELKSYSG
                     KHTWADELVLGGALFMANGKFKNPNDWSEVDKRREINNEHPLLMMPLYANGEEFNQGK
                     YTFWGGDTLTGKWENIPDDLKPYTVIQLHPDDLPKRDGAARDFYEHMLEEAAKYVNPK
                     TGKNEPIPVILTVYTAGNMPYYTSAHWLSTSWIDKMYQKYPNLHGIFSTENYWIWAND
                     IENKAADYLKVSAKNGGYFIWAEQNNGSAIEKAFGKNGKIAFQKSVDKYWKNLIFMFK
                     NTPAAEGNDSTTESYMKGLWLSNHTYQWGGLMDTWKWYETGKWKLFASGNIGKSQGDR
                     QWLTEPESMLGEEALGVYLNGGVVYNFEHPAYTYGVNNKESLLFSEVIKEFFRYVIAH
                     PAPSKEKVLEDTKVFIHGDYSNKGNGKFFVNVNTDREQTPLYMTGRYNVIPAIPGVLK
                     TDKLKESVSGSRIQIKEITSPEFSSTQARKEYLNKLYPMNYEGDIFAQKLDNRWFVYN
                     YKVNENVKQTGKLKFNSLEMDVEFEPHTYGIFERISNGLKVNLNNFRTNKDSLWSNAQ
                     DANQAKKLPQLTKKGAIKWIEEHYIKDTQFGEKRVTKIVLRGIDKLPTIHSLSGTNNS
                     YDQPSLNFDQKNHMVTITINSNGNLEFELHF"
     gene            25090..25818
                     /locus_tag="VVR18_000333"
     CDS             25090..25818
                     /locus_tag="VVR18_000333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HEU6031932.1"
                     /translation="MSQDEKLIREQICDVCHKMWQLGWVAANDGNVSVRLDEDTILAT
                     PTGISKSFITPEKLVKLNLKGEILEAEGDYCPSSEIKMHIRCYEEREDVRSVVHAHPP
                     IATGFALAHIPLDTYSLIESAIVVGAIPITPFGVPSTMEVPEAITPYLPDHDVMLLEN
                     HGALTVGSDVITAYYRMETLELVAKTTFHGRMLLSTKGIEEQEIARPTLERLFSMREN
                     YKVTGRHPGYRKYNGDGSMKETEK"
     gene            25831..27597
                     /locus_tag="VVR18_000334"
     CDS             25831..27597
                     /locus_tag="VVR18_000334"
                     /EC_number="5.3.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="HEU6031933.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLK
                     YPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIP
                     HAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRY
                     ARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRG
                     IYDPEEFERAMVWVKEHIKEGVDRNREDLILSKEEKEKQWEFVIKMFMIGRDLMVGNP
                     RLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFAT
                     ENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSG
                     SCTLDGTGQATRDGKPVMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTK
                     GDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGK
                     GAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSL
                     FGTEDLESADYRACQLLGPLHK"
     gene            27743..28894
                     /locus_tag="VVR18_000335"
     CDS             27743..28894
                     /locus_tag="VVR18_000335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HEU6031934.1"
                     /translation="MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSD
                     ILPKVLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAA
                     SCISIMATNGGRPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMV
                     MVDKNSLALISVNDPELMLSKPQALTAATGMDALTHAVEALVTPGAYDVTKKLSIGAI
                     ELIKEYLPRAVENGHDIEAREGMVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHG
                     VCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADYAIAEIEKLSETVGI
                     PKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF"
     gene            29039..29923
                     /locus_tag="VVR18_000336"
     CDS             29039..29923
                     /locus_tag="VVR18_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEU6031935.1"
                     /translation="MIFLIVCVLLLVIVTLSTVYVVRQQSVAIIERFGKYQKVANSGI
                     HIRLPFGIDSIAARIQLRLLQSDIVVETKTKDNVFVMMNVATQYRVNEQSVTDAYYKL
                     IRPESQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMTTYGYIIVKTLI
                     TKVEPDAEVKQSMNEINAAQRKRVAAQELAEADKIKIVTAAEAEAEKDRLHGVGIAQQ
                     RKAIVDGLAESITELKEANVGMTEEQIMSILLTNQYLDTLNTFASKGNQTIFLPNTPN
                     GVDDIRTQILSALRAEKK"
     gene            complement(30086..30163)
                     /locus_tag="VVR18_000337"
                     /pseudo
     CDS             complement(30086..30163)
                     /locus_tag="VVR18_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            30367..30618
                     /locus_tag="VVR18_000338"
     CDS             30367..30618
                     /locus_tag="VVR18_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657761.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEU6031936.1"
                     /translation="MKEFQFERKQRFSLRKYAIGACSVLLGTSLFFAGMGDQPVQDTE
                     TSSALISSHYLDEQDLSEKLKSELQWFELENKLLNLWEH"
     gene            30606..30896
                     /locus_tag="VVR18_000339"
     CDS             30606..30896
                     /locus_tag="VVR18_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000501069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031937.1"
                     /translation="MGALGYYEGFVPYVSNQYKNQAEEEGKPLSDKYIFEKILGKTYA
                     AFKKDQINERVEKLGKLKPITINYNGKSEVIDSKEKLQELMNKAVKDEVAQI"
     gene            complement(31079..31206)
                     /locus_tag="VVR18_000340"
                     /pseudo
     CDS             complement(31079..31206)
                     /locus_tag="VVR18_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001836165.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="fucose isomerase"
     gene            complement(31300..32631)
                     /locus_tag="VVR18_000341"
     CDS             complement(31300..32631)
                     /locus_tag="VVR18_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HEU6031938.1"
                     /translation="MKIDITNQVKDEFLISLKTLISYPSVLNEGENGTPFGQAIQDVL
                     EKTLEICRDIGFTTYLDPKGYYGYAEIGQGAELLAILCHLDVVPSGDEADWQTPPFEA
                     TIKDGWVFGRGVQDDKGPSLAALYAVKSLLDQGIQFKKRVRFIFGTDEETLWRCMARY
                     NTIEEQASMGFAPDSSFPLTYAEKGLLQVKLYGPGSDQLELEVGGAFNVVPDKANYQG
                     PLYEQVCNGLKEAGYDYQTTEQTVTVLGVPKHAKDASQGINAVIRLATILAPLQEHPA
                     LSFLATQAGQDGTGRQIFGDIADEPSGHLSFNVAGLMINHERSEIRIDIRTPVLADKE
                     ELVELLTRCAQNYQLRYEEFDYLAPLYVAKDSKLVSTLMQIYQEKTGDNSPAISSGGA
                     TFARTMPNCVAFGALFPGAKQTEHQANECAVLEDLYRAMDIYAEAVYRLAT"
     gene            complement(32653..34164)
                     /locus_tag="VVR18_000342"
     CDS             complement(32653..34164)
                     /locus_tag="VVR18_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004191872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HEU6031939.1"
                     /translation="MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYET
                     QPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAIDVAFFILMVGGFLGIVNKTGA
                     LDVGIASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS
                     LTGVAIILLGSQIGCLASTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFV
                     YRYADKIQKDPTKSLVYSTRKEDLKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMV
                     LSFIPWTDLGVTIFDDFNAWLTGLPVIGNIVGSSTSALGTWYFPEGAMLFAFMGILIG
                     VIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGL
                     SSQVFIVVTYIFYLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGV
                     LNLIAPTSGIVMGALALGRINIGTWWKFMGKLVVAIIVVTIALLLLGTFLPFL"
     gene            complement(34375..35322)
                     /gene="arcC"
                     /locus_tag="VVR18_000343"
     CDS             complement(34375..35322)
                     /gene="arcC"
                     /locus_tag="VVR18_000343"
                     /EC_number="2.7.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamate kinase"
                     /protein_id="HEU6031940.1"
                     /translation="MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGD
                     DLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDE
                     GIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWR
                     KVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVIKENNGHLTGVEAVIDKDFAS
                     QRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPK
                     VEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG"
     gene            complement(35487..36503)
                     /gene="argF"
                     /locus_tag="VVR18_000344"
     CDS             complement(35487..36503)
                     /gene="argF"
                     /locus_tag="VVR18_000344"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003073325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HEU6031941.1"
                     /translation="MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIQHHY
                     LAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRM
                     FDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLV
                     YCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEKEIVELAEGFAKESGAHVLITED
                     ADEAVKDADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKAGNENLIFLHCLPA
                     FHDTHTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLY
                     IPKV"
     gene            complement(36561..37790)
                     /gene="arcA"
                     /locus_tag="VVR18_000345"
     CDS             complement(36561..37790)
                     /gene="arcA"
                     /locus_tag="VVR18_000345"
                     /EC_number="3.5.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine deiminase"
                     /protein_id="HEU6031942.1"
                     /translation="MSSHPIQVFSEIGKLKKVMLHRPGKELENLLPDYLERLLFDDIP
                     FLEDAQKEHDAFAQALRDEGIEVLYLEQLAAESLTSPEIRDQFIEEYLDEANIRDRQT
                     KVAIRELLHGIKDNQELVEKTMAGIQKVELPEIPDEAKDLTDLVESEYPFAIDPMPNL
                     YFTRDPFATIGNAVSLNHMFADTRNRETLYGKYIFKYHPIYGGKVDLVYNREEDTRIE
                     GGDELILSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDT
                     VFTMVDYDKFTIHPEIEGDLHVYSVTYENEKLKIVEEKGDLAELLAQNLGVEKVHLIR
                     CGGGNIVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKILEEYGLRLIKIRGSELVR
                     GRGGPRCMSMPFEREEV"
     gene            38546..40225
                     /locus_tag="VVR18_000346"
     CDS             38546..40225
                     /locus_tag="VVR18_000346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HEU6031943.1"
                     /translation="MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQE
                     DPERFNPSQLDAREWVRVLKETGFKKLILVVKHHDGFVLYPTAHTDYSVKVSPWRRGK
                     GDLLLEVSQAATEFDMDMGVYLSPWDAHSLLYHVDREADYNAYYLAQLKEILSNPAYG
                     NGGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGNCLIFSTEGTSIRWIGNERGY
                     AGDPLWQKVNPDKLGTEAELDYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLE
                     ELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKDIERLYEFVTYRNELYKEDLALGAEVS
                     GPTLSADFACRHLTDGLETSSWASDADLPIQLELDLGSPKTFDVIELREDLKLGQRIS
                     AFHVQVEVDGVWQEFGRGFTVGHKRLLRGPLVEAQKVRVMITEAQSIPVLTKISLYKT
                     PGLSKKEVVQELAFAEKSLAVAKGETLHFRIERSESSSSLEAKISIQPGTGVHGVAYQ
                     DEIQVLAFQAGETEKSLTLPTLYFAGDKTLDFYLNLTVDGQLVDQLQVQVS"
     gene            complement(40265..42349)
                     /locus_tag="VVR18_000347"
     CDS             complement(40265..42349)
                     /locus_tag="VVR18_000347"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000803403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH92 family glycosyl hydrolase"
                     /protein_id="HEU6031944.1"
                     /translation="MKPLLETIDTRLGTTNRHAFSRGNTLPYTGVPFGMNYFVPQTSD
                     QDGAWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTSQLGGDSLFHRQSSYDRDK
                     ASFQPHYLKIFSLRYQIETQLTPTCYGASIRLKQKQGKALSLYLHAADELTVEQVDKR
                     TLALRQEGKTETNKNSLTMFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS
                     PSQALINLPQEDFDSCKASAQADWENLLHRFDIIETGEADRTFFDHCLYRLFLFPQTF
                     YEVDESGQAIHMDLATGTVKPGVLFSNNGFWDTFRTTFPLFALIIPEHYQRFLEGFLN
                     SYRDTGFLPKWLAPDERGMMPGTLLDGIIADSTCKDMAPDLEGELFQAMLETASKADP
                     LGINGRHGLAQYQELGYLSTDHHESVSHTLDYAYSDFCIASCAKKLENIEIAETYKAA
                     SQNYRQLFDAETGYMRARDNQGNFHPDFSPYSWGRDYAECSAIQATLGVLHDIPGLIQ
                     LMGGKETFSNYLLKTCQDAPLFEITGYGYEIHEMSEMATAPFGQIAISNQPSFHIPYL
                     FRYSDYPDYTALLIKTLRQKAFHPSWEAYPGDEDNGSLSAWYIWSALGFYPTCPGKPS
                     YDLGIPLFDHLRVYLAKEDKWLDIHTKQNHNHFNFVKECRLDKTLVSTIQHQDLLKAE
                     QLTFTLSWLPSH"
     gene            42520..43800
                     /locus_tag="VVR18_000348"
     CDS             42520..43800
                     /locus_tag="VVR18_000348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HEU6031945.1"
                     /translation="MIYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL
                     EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDALLRQTIAGLVKRQMTLVLKDPYA
                     NSFNIEENWKGHHETDHTDLNGWIWERKYEVDSLCYPLQLAYLLWKETGETSQFDETF
                     VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD
                     DCCQYSYLIPSNMFAVVVLGYVQEIFAALNLADSQSVIADAKRLQDEIQEGIENYAYT
                     TNSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSVDDEVYQATRRTILSSEN
                     PYFYQGEYASGLGSSHTFYRYIWPIALSIQGLTTRDKAEKNFLLDQLVACDGGTGLMH
                     ESFHVDDPTLYSREWFSWANMMFCELVLDYLDIR"
     gene            43891..46536
                     /locus_tag="VVR18_000349"
     CDS             43891..46536
                     /locus_tag="VVR18_000349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HEU6031946.1"
                     /translation="MENVVVHIISHSHWDREWYLPFESHRMQLVELFDNLFDLFENDP
                     EFKSFHLDGQTIVLDDYLQIRPENRDKVQRYIDEGKLKIGPFYILQDDYLISSEANVR
                     NTLIGQQEAAKWGKSTQIGYFPDTFGNMGQAPQILQKSGIHVAAFGRGVKPIGFDNQV
                     LEDEQFTSQFSEMYWQGVDGSRVLGILFANWYSNGNEIPVDKDEALTFWKQKLSDVRA
                     YASTNQWLMMNGCDHQPVQKNLSEAIRVANELFPDVIFVHSSFDEYVQAVEGALPEHL
                     STVTGELTSQETDGWYTLANTSSSRIYLKQAFQENSNLLEQVVEPLTIITGGHNHKDQ
                     LTYAWKTLLQNAPHDSICGCSVDEVHREMETRFAKVNQVGNFVKSNLLNEWKGKIATD
                     KAQSDYLFTVINTGLHDKVDTVSTVIDVATCDFKELHPTEGYKKMAALILPSYRVEDL
                     DGRPVEATIEDLGANFEYDLPKDKFRQARIARQVRVTIPVHLAPLSWTTFQLLEGKQE
                     HREGIYQNGVIDTPFVTVSVDDNITVYDKTTHEAYEDFIRFEDRGDIGNEYIYFQPKG
                     TEPIFAELKGHEVLENTACYAKILLKHELTVPVSADEKLEEEQQGIIEFMKREAGRSE
                     ELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSESIYEVVT
                     RPNKPAASWENPENPQHQQAFVSLYDDEKGVTVSNKGLNEYEILGDNTIAVTILRASG
                     ELGDWGYFPTPEAQCLREFEVEFALECHQAQERFSAYRRAKALQTPFTSLQLARQEGS
                     VVATGSLLSHSVLSIPQVCPTAFKVAENEEGYVLRYYNMSQENVRISEHQQTILDLLE
                     RPYPVHSGLLAPQEIRTEFIKKEEI"
     gene            46620..47489
                     /locus_tag="VVR18_000350"
     CDS             46620..47489
                     /locus_tag="VVR18_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEU6031947.1"
                     /translation="MTIATIDIGGTGIKFASLTPDGKILDKTSISTPENLEDLLAWLD
                     QRLSEQDYSGIAMSVPGAVNQETGVIDGFSAVPYIHGFSWYEALSSYQLPVHLENDAN
                     CVGLSELLAHPELENAACVVIGTGIGGAMIINGRLHRGRHGLGGEFGYMTTLAPAEKL
                     NNWSQLASTGNMVRYVIEKSGHTDWDGRKIYQEAAAGNALCQEAIERMNRNLAQGLLN
                     IQYLIDPDVISLGGSISQNPDFIQGVKKAVDNFVDAYEEYTVAPVIQACTYHADANLY
                     GALVNWLQEEKQW"
     gene            47483..49363
                     /locus_tag="VVR18_000351"
     CDS             47483..49363
                     /locus_tag="VVR18_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HEU6031948.1"
                     /translation="MVRFIGLSPKQTQAIEVLKGHISLPDVEVAVTQSDQASISIEGE
                     EGHYQLTYRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVAS
                     AKQMIEILALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF
                     VPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMFATLSKLKTRKVN
                     IGMDEAHLVGLGRYLILNGVVDRSLLMCQHLERVLDIADKYGFHCQMWSDMFFKLMSA
                     DGQYDRDVEIPEETRVYLDRLKDRVTLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAG
                     GAWKWIGFTPHNHFSRLVAIEANKACRANQIKEVIVTGWGDNGSETAQFSILSSLQIW
                     AELSYRNDLDSLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDVL
                     CPILDRHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQAQLNAILSSKVDVGRRI
                     RQAYQADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENKVFGLDTVDIRMGGLL
                     QRIKRAESRIEVYLAGQLDRIDELEVEILPFTDFYADKDFAATTVNQWHTIATASTIY
                     TT"
     gene            49776..49916
                     /locus_tag="VVR18_000352"
     CDS             49776..49916
                     /locus_tag="VVR18_000352"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031949.1"
                     /translation="MILWSFDFVNDHAHAFFMDNVEWSHADSYFLSFVSDDVEERYQN
                     NI"
     gene            complement(50000..50805)
                     /locus_tag="VVR18_000353"
                     /pseudo
     CDS             complement(50000..50805)
                     /locus_tag="VVR18_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(50750..50932)
                     /locus_tag="VVR18_000354"
     CDS             complement(50750..50932)
                     /locus_tag="VVR18_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6031950.1"
                     /translation="MDLKFEGVDLEYKKAKNNLPESFWETYSAFANTNGGKIILGIDE
                     KNIDTYQRVNRLPAKL"
     gene            51267..>52753
                     /gene="pcpA"
                     /locus_tag="VVR18_000355"
     CDS             51267..>52753
                     /gene="pcpA"
                     /locus_tag="VVR18_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000753868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein PcpA"
                     /protein_id="HEU6031951.1"
                     /translation="MKKTTILSLTTAAVILAAYVPNEPILADTPSSEVIKETKVGSII
                     QQNNIKYKVLTVEGNIGTVQVGNGVTPVEFEAGQDGKPFTIPTKITVGDKVFTVTEVA
                     SQAFSYYPDETGRIVYYPSSITIPSSIKKIQKKGFHGSKAKTIIFDKGSQLEKIEDRA
                     FDFSELEEIELPASLEYIGTSAFSFSQKLKKLTFSSSSKLELISHEAFANLSNLEKLT
                     LPKSVKTLGSNLFRLTTSLKHVDVEEGNESFASVDGVLFSKDKTQLIYYPSQKNDESY
                     KTPKETKELASYSFNKNSYLKKLELNEGLEKIGTFAFADAIKLEEISLPNSLETIERL
                     AFYGNLELKELILPDNVKNFGKHVMNGLPKLKSLTIGNNINSLPSFFLSGVLDSLKEI
                     HIKNKSTEFSVKKDTFAIPETVKFYVTSEHIKDVLKSNLSTSNDIIVEKVDNIKQETD
                     VAKPKKNSNQGVVGWVKDKGLWYYLNESGSMATGWVKDKGLWYYL"
BASE COUNT        16254 a         9339 c        11209 g        15951 t
ORIGIN      
        1 actcccctga aatttatttt aattatgcaa atttcacgta tttttgatgc tgagacgacg
       61 atcctgggaa cttttcagat atttttttga ctatctaaat ctatcattag aaaagcttag
      121 agcgccaaag gatttgagcg tttttctgat ttttaagact ttttccagtc tctttttcga
      181 ttgaagatgt aattattcta ctaactaact aacttcttag tactagccaa caacgataat
      241 cataattcct cctaaaatta ggaataataa aggcaatagt ttttgttttt tcatgtaaaa
      301 aacctcactt ttgttttctg ctattttatg ctaaaatatt aaaaatcaaa tttaattcca
      361 aagtttgtaa ctaaaggggg agcgctacat gtctaattca tttgtcaagt tgttagtctc
      421 tcaattattt gcaaatttag cagatatttt ctttagagta acaatcattg ctaacatata
      481 cattatttca aaatcagtaa ttgccacatc actagttcct atcttaatag gaatatcctc
      541 ttttgttgcg agtcttttag ttccgttggt tactaaaagg ttagcgctaa atagggtttt
      601 atctttatct caatttggaa agactatatt attggcgata ctggtaggaa tgtttaccgt
      661 aatgcaatcc gtagcgcctt tggtgaccta tctatttgtt gttgcaattt ccatactaga
      721 tggttttgca gcacccgttt cctatgctat tgtgccacgc tatgcgaccg atttgggtaa
      781 ggctaattca gccttatcaa tgactggtga agctgttcaa ttgataggtt ggggattagg
      841 tggactcttg tttgcaacaa ttggtctgtt acctaccacg tttatcattt tagtcttgta
      901 tatcatttct agctttctga tgttatttct tcctaacgct gaagtggagg tgttagagtc
      961 agaaactaat cttgaaattt tgctcaaagg ttggaagtta gttgctagaa atcctagatt
     1021 aagacttttt gtatcagcaa atttattgga aattttttca aatacgattt gggtttcttc
     1081 cattatactt gtttttgtaa cggagttatt aaataaaacg gaaagttact ggggatattc
     1141 taatacagca tactctattg gtattataat tagtggctta attgctttta ggctatctga
     1201 aaagttcctt gctgctaaat gggaaagtat tctttttcct cttgtagcta tggcaatagt
     1261 gacactgact attctatatt ttccaaacgc acagatgttt ttattatttt cagctttagt
     1321 tggtatgtta tcgcaactaa aagaagttcc tgaaagtgta tttcttcagg aaacagtaga
     1381 ggaaaatcat ttagttaatg tctattccgt tcttgaagtg atttctacat tagcattttc
     1441 agtatttgtt ttgctaatga gctatattac tgagagtttt ggtattagca tcagtttttg
     1501 gctatcagcc atttgtctga tgatagaagc tattttaatt tatatcagac gagattattt
     1561 taaatgagag agtggttaaa aagtctttaa aaatcagaaa agcgcatagt atcaggtgtt
     1621 gaaaaaactt gatattgtgt gttttattat gggaagattt acttcattgt ctcctgaaat
     1681 ggagttttga agcaggatca ctctatttga aaatatacat agaaaaaccg cataatcctt
     1741 aaaataagct gaaatctatt ggaaacatac ggtaaacaat tgaaaagata ctatataaag
     1801 tggtacaatg gtagaaaaat aagctagtaa gaatcactct tattttagcg aattttagcg
     1861 aaaaattaca gaaatgaatg gtttttcttg atgaaacaga gaaaagaatt gtacctcttt
     1921 cttggtcgga cagccttgta ttttcttatc tttctagggc tgctttactt ctttagctat
     1981 cttggtcagg gtcaaggaag ctttatctat aatgaatttt aacttgaagg agaatcccta
     2041 ttgtgtcaaa taaaccaata gcagatatga ttgaaaccat tgagcatttt gctcagacac
     2101 agcctagcta tcctgtctat aatgttttgg ggcaggaaca cacttatggc gatttaaagt
     2161 ctgattcgga tagtttggct gcagtcattg accaactagg cttgcctgag aagtctcctg
     2221 tggttgtttt tggtggccaa gaatatgaaa tgttggcaac ctttgtagcg ctgactaagt
     2281 caggtcatgc ctacattcca attgatagcc attcggcctt ggagcgagtt tcagctattt
     2341 tagaagtagc agagccaagc ttgattattg ccatttcagc ctttcccttg gagcaggttt
     2401 ctacaccaat gataaatcta gctcaggttc aagaagcctt tgcccaaggg aacaactatg
     2461 aaatcacgca tccagtcaag ggagatgata attactacat tatctttact tctggtacga
     2521 ctggtcagcc taagggagtg cagatttcac atgataatct cctcagcttt acaaactgga
     2581 tgattacgga taaggaattt gcgacaccga gtcgtccgca aatgctggca cagccacctt
     2641 attcttttga cttgtctgtc atgtattggg caccgacctt ggcacttggt ggtacgcttt
     2701 tcactcttcc ttcagtcatc actcaggact ttaagcaact ctttgcggct atcttttcat
     2761 tgccaatcgc tatctggaca tcaacaccat cctttgcaga tatggccatg ttgtctgaat
     2821 acttcaacag tgagaaaatg cctggaatca cgcatttcta ctttgatggt gaagaattga
     2881 cggtcaaaac agctcaaaaa ctgcgcgagc gtttcccaaa tgcccgtatc atcaatgctt
     2941 acggcccaac agaagcgaca gtagctctgt cagcagttgc cgtgacagac gagatgttag
     3001 cgactctcaa acgcctacca atcggctata ccaaggctga ttctccaacc tttatcattg
     3061 acgaggaagg aaataaactg ccaaatggtg agcagggaga aatcattgtt tctgggccag
     3121 ctgtttcaaa aggttatatg aacaatcctg aaaaaacagc agaagccttc tttgagtttg
     3181 aagatctgcc agcctatcac acaggcgatg tgggaaccat gacagatgag ggcttgcttc
     3241 tctacggcgg acgcatggac ttccagatta agtttaacgg ttaccgcatt gagttagaag
     3301 atgtctctca aaacctcaac aagtctcgct ttatcgaatc tgctgtcgca gtaccgcgct
     3361 ataacaagga ccacaaggta caaaatctat tggcttatgt catcttaaaa gacagtgttc
     3421 gtgagcagtt tgagcgagat atcgatatta ccaaggccat caaggaagac ctgacagaca
     3481 tcatgatgtc ctacatgata ccatctaaat tcctttaccg agacagtttg ccactgactc
     3541 caaatggaaa gattgacatc aaaggattga ttaacgaggt gaataagaga tgatggagtt
     3601 ttttcaacag cttcctcatt tagagccata tggcaatcct cagtattttg tttatgtgat
     3661 tgctgcaacc ttgcccatct ttataggtct ctttttcaag aaacgctttg cctggtatga
     3721 agtgttggta agtctcttct ttattgtcac catgttggtg ggtggaaaga ccaatcaact
     3781 agctgccttg ggtatttacc tttgctggga aatattgctc ctgcttttct acaagcatta
     3841 tcgaaaaagc aaggatggca agtgggtctt ctacttagtt agttttctgt ccctacttcc
     3901 gattatcttt gtcaaggtgc aaccagctat caatggaacg cagtctttgc ttgggttctt
     3961 gggaatttct tacctgacct ttcgttcggt tgggattatc atcgagctga gagatggagt
     4021 gattaaggat tttaccctct gggaattcct ccgtttcctt ctcttcatgc caactttctc
     4081 gagtggtcca atcgatcgct ttaagcgatt taatgaaaat tatcaggcca ttcctgagcg
     4141 agatgagttg atggatatgc tggatgaatc tgtccgctat atcatgcggg gctttttgta
     4201 taagtttatc ctagctcatg ttttaggaga gaccttacta cctcctctga agaatttagc
     4261 cttgcagtca ggtggcttct ttaatctcta tgccttggca gttatgtata cttttggtct
     4321 ggagctcttc tttgactttg caggttattc tatgtttgct ttggccatct caaacttgat
     4381 gggaatccgt agccctatca actttaacaa gcccttttta tcaagggatt taaaggagtt
     4441 ttggaatcgc tggcatatga gtctgtcctt ctggttccgt gactttgtct ttatgcgaat
     4501 ggtgatggtg ttaaccagaa agaaagtctt taaaaatcgt aatgtaacct caagcatggc
     4561 ctacattgta aatatgctga ttatgggatt ttggcatggc gtgacctggt actatatcgc
     4621 ctatggactc tttcatggac taggtttggt catcaatgat gcctgggttc gcaagaaaaa
     4681 aacgctcaat aaggaacgga aaaaagcagg gaaggctgcc ctacctgaga atcgctggat
     4741 tcagttgctt ggcatggttg tcactttcca tgttgtcatg ttgtcattct taatcttttc
     4801 tggattcttg aataatctat ggtttaaaaa ataaaaggaa ataaaatatg gatatcaaat
     4861 cagaagttat tgaaattatt gatgagttgt ttatggaaga tgtttctgac atgatggatg
     4921 aagatctttt tgatgcaggt gtcttggata gtatgggaac ggttgagttg attgtggaga
     4981 ttgagaaccg ttttgacatt cgtgtccctg taacagagtt tggtcgtgac gactggaata
     5041 cagctaataa aatcatagct ggtattgtgg agctacaaaa tgcttaaacg cttatggatg
     5101 atcttcggac cggtcttgat cgctggtttg ttggtttttc tgctcatttt cttttatcct
     5161 actgagatgc atcataatct aggagctgaa aagcgttcag cagtggctac tactatcgat
     5221 agttttaagg agcgaagtca aaaagtcaga gcactatctg atccaaatgt gcgttttgtt
     5281 cccttctttg gctctagtga atggcttcgt tttgacggtg ctcatcctgc ggtattagct
     5341 gagaaataca atcgttccta ccgtccttat cttttaggac aggggggagc tgcatcgctt
     5401 aaccaatatt ttggaatgca acagatgtta ccacagctgg agaataaaca agttgtgtat
     5461 gttatctcac ctcagtggtt cagtaaaaat ggctatgatc cagcagcctt ccagcagtat
     5521 tttaatggag accagttgac tagttttctg aaacatcaat ctggggatca ggctagtcaa
     5581 tatgcagcga ctcgcttact gcaacagttc ccaaacgtag ctatgaagga cctggttcag
     5641 aagttggcaa gtaaaggaga attgtcgaca gcagacaatg aaatgattga attattggct
     5701 cgttttaatg aacgccaagc ctcctttttt ggtcagtttt cggttagagg ctatgttaac
     5761 tacgataagc atgtagctaa gtatttaaaa atcttgccag accagttttc ttatcaagca
     5821 atagaagatg ttgtcaaagc agatgctgaa aaaaatactt ccaataatga gatgggaatg
     5881 gaaaattatt tctataatga gcagatcaag aaggatttga agaaattaaa ggattctcag
     5941 aaaagcttta cctatctcaa gtcgccagag tataatgact tgcagttggt tttaacacag
     6001 ttttctaaat ctaaggtaaa cccgattttt atcattccac ctgttaataa aaaatggatg
     6061 gactatgctg gtctacgaga ggatatgtac caacaaacgg tgcagaagat tcgctaccag
     6121 ttagaaagtc aaggttttac caatatagca gatttttcta aggacggcgg ggagcctttc
     6181 tttatgaagg acaccattca ccttggttgg ttgggttggt tggcttttga caaggcagtt
     6241 gatcctttcc tatccaatcc cacaccagct ccgacttacc atctgaatga gcgctttttc
     6301 agcaaagatt gggcgactta tgatggagat gtcaaagaat ttcaatagat aatataatat
     6361 agaagagttc aagaatgaaa ctagttttca cgttttttct tgactctttt tttgcttgtg
     6421 atataattaa ctggtaaaca aaatgtcaaa gaatagtatt tttctcttaa aaaagagaag
     6481 tctaaaagga aaggagtcag atatgagaca gctagcaaag gatatcaatg cttttttgaa
     6541 tgaggtgatt ttgcaggcgg aaaatcagca tgaaatccta ataggtcatt gcactagcga
     6601 ggtggccctg accaatactc aggagcatat ccttatgctc ttgtcagagg aatctttaac
     6661 aaattcagaa ttggcccgtc gtctcaatgt cagtcaggcg gcagttacca aggccattaa
     6721 gtctttggtc aaggaaggga tgttggaaac atctaaagat tctaaagatg cgcgtgtgat
     6781 tttttatcag ttgactgact tggctcgtcc aatcgctgag gagcaccacc atcaccatga
     6841 gcatacactt ttaacctatg aacaagtggc gactcagttt actccaaatg aacaaaaagt
     6901 gattcagcgg tttttgactg ctttagtagg agaaatcaaa taatgagata tattacggta
     6961 gaggatttgt ccttctatta tgataaggag cctgttcttg aacatatcaa ttattgtgtt
     7021 gatagtgggg aatttgttac cttgactggg gaaaatggag cggctaagac gacgctcatc
     7081 aaggctagtc ttggaattct gcaaccacgc attggaaagg tggctatttc aaagacaaat
     7141 acgcaaggta agaaattgag aatagcctat cttcctcaac aaattgccag ttttaatgct
     7201 ggttttccaa gtacggtcta tgaatttgtc aagtcgggtc gctatccgag aaaaggctgg
     7261 ttccgtcgtt tgaatgctca tgatgaggag catatcaagg ccagtctgga ctcagttggc
     7321 atgtgggaac atcgagacaa acgcttgggt tctctatctg ggggacaaaa gcagcgagcg
     7381 gtgattgcgc gtatgtttgc ttctgaccct gatgtgttta tcctagacga gccgacaacg
     7441 gggatggatg caggaagtaa aaatgaattt tacgaactca tgcaccacag cgcccatcat
     7501 catggcaagg ctgttttgat gattacccat gaccctgaag aagttaagga ttatgcggat
     7561 cgcaatattc atctagtccg taaccaagac tcgccatggc gttgtttcaa tgttcatgag
     7621 aatggccagg aggtgggcca tgcttagttt attatcttac gactttatac agcgcgcctt
     7681 tttggcggtt attgctatga gtcttttctc accggtattg ggaaccttcc tcatcttgcg
     7741 tcgtcagagt ttgatgagtg atacccttag ccacgtctca ctttcaggtg tagcctttgg
     7801 tctggttttg gggatttctc caactgtttc tactattgcc attgtcttga ttgcggcggt
     7861 ctttctggag tatctccgta cggtttacaa gagctttatg gaaatcggga cagctatcct
     7921 catgtcaaca ggtctggctg tttctctgat tgtcatgagc aagggtaaaa gctcgagttc
     7981 aatgagtttg gaccaatatc tctttggttc gatcgtgact atcagtgaag aacaggtcat
     8041 ttccctcttt gtcattgcgg tggttgtttt gattttgacc tttctctttc ttcgtcctat
     8101 gtatatctta acttttgacg aagatacggc ctttgtggat ggcttgccag ttcgtaccat
     8161 gtccattctt tttaacatgg tgacaggggt ggctattgcc cttatgattc ctgcagcagg
     8221 agctcttctg gtatcgacca ttatggtctt gccagctagt attgccctgc gtctggggaa
     8281 aaactttaaa tcggttatgc tgcttgccag tgcgattggc tttttgggaa tggtagcagg
     8341 actttacatt tcctactatg cagaaacacc tgcaagtgca agtattacca ttatttttgt
     8401 aactgtcttt atactaatca gtttagtaag acgttttatc aaataggaga cgaacgtgaa
     8461 aaaaattagc ttattactag ccagtctatg tgccttgttt ttagtggctt gttccaatca
     8521 aaaacaggca gatggtaaac tcaatatcgt gacaaccttt taccctgtct atgaatttac
     8581 caagcaagtc gcaggagata cggctaatgt agaactccta atcggtgctg ggacagaacc
     8641 tcatgaatac gaaccatctg ccaaggcagt tgccaaaatc caagatgcag ataccttcgt
     8701 ttatgaaaat gaaaacatgg aaacatgggt acctaaattg ctagatacct tggataagaa
     8761 aaaagtgaaa accatcaagg cgacaggcga tatgttgctc ttgccaggtg gcgaggaaga
     8821 agagggagac catgaccatg gagaagaagg tcatcaccat gagtttgacc cccatgtttg
     8881 gttatcacca gttcgtgcca ttaaactagt agagcacatt cgtgacagct tgtcagcaga
     8941 ttatcctgat aaaaaagaga cctttgagaa gaatgcagct gcctatatcg aaaaattgca
     9001 agccttggat aaggcttacg cagaaggctt gtctcaagca aaacaaaaga gctttgtgac
     9061 tcaacacgca gcctttaact atcttgcctt ggactatgga ctcaaacaag tcgcaatctc
     9121 aggactttct ccagatgcag agccatcagc tgctcgcttg gcagaattga cagagtatgt
     9181 caagaaaaat aaaatcgcct atatctattt tgaagaaaat gcctcacaag cccttgctaa
     9241 cacactttca aaagaagcag gtgtcaaaac tgatgtcctc aatcctttag aaagtctgac
     9301 agaagaggac accaaggctg gagaaaacta catttccgtg atggagaaaa acctcaaggc
     9361 tttgaaacaa acaacagacc aagaaggccc agcaatcgaa cctgaaaagg cagaggatac
     9421 caagacagtc caaaatggtt acttcgagga tgcagctgtc aaggaccgca ccttgagtga
     9481 ctatgcaggt aactggcaat cagtttatcc tttccttgaa gacggcacgt ttgaccaagt
     9541 ctttgactac aaggctaagt tgactggtaa gatgacccag gctgagtaca aggcttacta
     9601 tacaaaaggc tatcatacag atgtgactaa gattaacatt actgataata ctatggaatt
     9661 tgttcaaggt ggacaaagca agaaatacac ttacaagtat gtcggtaaga aaattttgac
     9721 ttacaagaaa ggcaatcgtg gcgtgcgttt cctctttgaa gccacagatg ctgacgctgg
     9781 acaattcaag tatgttcagt ttagtgacca caatatcgcc ccagttaagg cagaacattt
     9841 ccatatcttt tttggaggca caagccaaga agccctcttt gaagaaatgg acaactggcc
     9901 aacctactac ccagataacc tatctggcca agaaatcgcc caagaaatgt tggcgcattg
     9961 atgagaaatc gactagttca taagagctag tcggtttttt gatactagat ggctaacttc
    10021 attatagacc tttcagaact aaggaacttt aaaaaaataa ataaaactct tgaaatatta
    10081 ggacttatat gctagaatgt agttagtgta taaggttcat tagaacacca aagcccctaa
    10141 ctagtgccat agttaagggc ttttttgacg tatcttagcg atttaacggg tgtttatagg
    10201 ctagtcagtc ggtctacttc ttaccatcta gccatttgca gacgaaatac aagataattc
    10261 cagctataac atctgctata atagtaagag caagctctgg tataaggctc attagtttca
    10321 cctcctctca cgaacccata ggaacgtaat cggtaaccga tgacaaaagt attataccac
    10381 actaaattta gatcatcaac ctcacttaat gcttgaacta ttgtagatta tatgctaaaa
    10441 tgtagttaat tgataaggtt cattagaaca ccaaagcccc taactatggc cgtagttaag
    10501 ggcttttttg acgtatctta gcgatttaat gggtgtttat aggctagtca gtcggtctac
    10561 tccttactat ctagccatct gcagacgaaa tacaagataa ttccagctat aacatccgct
    10621 ataatagtaa gagcgagctc tatgataagg ctcattagtt tcacctcctc tcacgaaccc
    10681 ataggaacgt aatcggtaac cgatgacaaa aatagtatac cacaatacat ttagatcatc
    10741 aaggtcactt aattcttgaa atatagggtc taggcgacaa agtctttaaa atcagaaaaa
    10801 cgcataatat caggtgtgca aaaacttgat actatgcgtt ttattgtggg aaggtttact
    10861 ccattttctc ctgaaattga gtttttgtcc agcctctgtt tttagggttg ctaagaaaat
    10921 aatgtcatgt ggtgaatatt tgtaaatcag tcagcagaca gaacgatact cttcgaaaat
    10981 ctcttcacat catgtcagct tcgtctttcc gtgtccatgg gggacttgac ttcatcagtt
    11041 ttcaaatctg tactttgagc aagctgagac tagcttccta tttgattttc attgaatatc
    11101 agaaacccat tctccatcaa ataattcgac tgcgtctaat aatttttggt ctggcacggt
    11161 gtcagaaata aaggttgtgt atttggagag gggattaatt ttaaaaaatc cagtcttgta
    11221 aaatttagaa ctatcaatca gtaagatagt ttcatgggct ttgtcaataa tattcttttt
    11281 tgaaatagct tggctgagag aagcttcata aacatattgg tcatcaatac ctcttgctga
    11341 acaaaatgct aaatcgatat taaaatgatc taataaagaa ttttccttat cgtaattgac
    11401 cacggaacag gattgatgtt tgacctcgcc agatgtgata aagattttgg agctatcttt
    11461 aacagtttca gatagggttt gtgcagtatg taaaccattt gtaaaaataa tcaaattatc
    11521 aagttcagaa agatagggac aaagttcgta gacagtagta ctggaatcca gataaacaca
    11581 cataccagac cgaataaagt ctttagcgag actagcgatt agtctttttt gcctagtact
    11641 ttctccttcc cgtatttgat gagaaagttc aattgtgttc atagaggaca gggtcacgta
    11701 tccgtgcttt cttttgataa gaccttgatt ttctaagaaa attaaatcac gacgtaaggt
    11761 acttgtgctg gagaaagtga tttctgccag ctcttttacg gcaattcttt ttttcttttt
    11821 aataatttca atcaattcaa gtacacgttc atcttttatc ataagctcct cctaatttat
    11881 catttcaact atattatagc acaaattgga ggaatttgaa ttatttttat gaatattggg
    11941 ttaacatttg aacattattc aagtaagcgt tcacatattg aaaaaataaa atgtggggat
    12001 tataataaag ttaatcaagg acgaagagag aagaaaaatg gaagcggttt tagcaataga
    12061 tttaggtgcg acttctggaa gagcaatcgt tggttacctt tctgaaaata aactagtaat
    12121 ggaagaaata aatcgctttt ctaatctacc tattagagta aaagggcatt tatcttggga
    12181 tattgacttt ctactagcta aaattcttga aagtatccgc ttggctaata ctagttacaa
    12241 gattttatct atcggtattg acacatgggg agttgatttt ggactgattg ataatgaagg
    12301 taagctgtta tcacaacctg ttcattatcg tgatgaaaga acaaagggag tgttaaagga
    12361 aatatctgaa atgactgaat tagaaaaact gtattcagag acaggaaatc agattatgga
    12421 gataaatacc ttgtttcaac tctttaaggc acgtcaagaa tctcctgact ctttctataa
    12481 gaccaataag attcttttaa tgccagattt gtttaattat ctcttgacag gtaagtttgc
    12541 tacagaaaaa agcattgctt caacaactca attatttgat cctaggagtc aaaattggaa
    12601 tcagaatatc ttaaaactat ttgaattgga ttcatcttta cttcctgaaa ttgtttcaga
    12661 gggaaatgtt cttggaagga taaaaaagga gtatggttta ggcgatattc ctgttgtgaa
    12721 tgtttgtagt catgatacag caagtgcgat tgtctcagta cctaagacag aaggtagttt
    12781 atttatttca tcaggtactt ggtctttggt tggagtggaa cttacttcac cgattcttac
    12841 taccgaatcc ttcagttatg gatttacaaa tgaagtcggt aaagatggag agattacatt
    12901 tctgaagaat tgtacagggt tgtggatcat agaggaacta agacgttcat ttgaacgaag
    12961 agggaaagcc tattcttttg atgatattag gacaatggtg gagaaagaaa aagaaaatct
    13021 tcctctgatt gatactgaat caactgaatt tgcaacagaa tctgatatgc acaagacttt
    13081 gacagaatat ctagcttatc atcatgaaac tagagagtgg acagatggac aactatttaa
    13141 gattgtttat gaaagcctag ctgaaacgta taggaaagcg atagagttat tagaagaact
    13201 aactcataag gtttataaga ggatatatgt gattggagga ggtgctagag ccagttactt
    13261 taaccaaatg attgctgata gaactggtaa agaggttctt acaggttcga ctgagggtac
    13321 agctgtgggg aatattgttg tgcagctatt gagtcaaggt aaaataaacg aggatacaga
    13381 gttaaaggat attatgacaa atattgctga tacaaaatat tattatcctc agctatcata
    13441 aacaaaaata aaaaaaacgg aggttttgtc atgaacaaaa aaagtctttt gaaatgcgct
    13501 gttatcgggt tagtagctac ctttggttta gcagcttgtg gaacatctaa ggatgcaagc
    13561 ggtggaagtt cttctggtaa agaagtatta gaattttatc atgggtatca tcatagtgaa
    13621 gatgaatggc ctgtagcgaa gactatgcga gatttatatg ataaatttgc agaagaacat
    13681 aaagatagtg gtgtagaatt taaaccaact cctgtaaatg gtgatttgaa ggatataatg
    13741 aataacaagg ttgctagtgg tgaatttcct gatgtgattg acctagcagg taatgcagta
    13801 tcattagctg cgattgaaca aaaacttgtt ttagatttga aaccatatat cgattcaaat
    13861 aagcttgaaa aaaatgttgg tttgaactat aagcaaaacc aaaaagatgg aaaaatttat
    13921 acagttcacg aacagttatt tacaatgggt ttgtggtaca acaaggacat atttgcaaaa
    13981 gcgggtgcta agacacctga tcagtggaat acttgggatg atttcactca ggcaatggca
    14041 agcattagaa aacaagatgg agtgtatgca tttggtgctg gagaaccatc tattcgcttg
    14101 tttaatacag tattaggaac cacagaaaat ggacgtaaat tattagataa accattaaca
    14161 aaagaaggaa ttgaatctaa agaatttgca gatgctttga aaatggttat gaaagaaatt
    14221 caagctaatg gttctaagaa tgctggtggc gatgccaatg cttattccaa agatttccaa
    14281 gaaggtaaat ctgcagtatt ctttaatggt gtgtgggctt ctggtgagat gtctaagaac
    14341 ccaagtcttg cacctggaat ctatcctgca ggtgtagcaa ttagttcttc tggaggtggt
    14401 atcactatct caagtaagat gtctgaagct aaacaaaaac tagctcttga gtttttgaaa
    14461 tatatgacta gcgatgatgt acaaaaagta atttttgaaa aagtaggagc aaatccttct
    14521 aatgaaaatg taaatgtaaa agaactttca gaaaagagtt cagaagctac tactaaaatt
    14581 ttaggacaag caatcactca agttaagaat gcaaaagcag ttgttccaac tgtaagtgat
    14641 gtttggggtg gcgatgtaca cacagctatt atcaatgcat tgacagaaag tgctgctgaa
    14701 aatgtagatg ttgatcaaaa agtaaaatct actcaagatg tgttgaaatc attgattggt
    14761 taattgtttt agggagtgaa aacgaagctc agttggcact gccaactgag cttgatttta
    14821 cttatatagt tgaaaaaaag gagtttgttt atggcacaaa aaattatgag cctacaaaat
    14881 aggaagaatc aaaaaagacg atttatcttt ttatttcttt tgccaacgtt gatttgtttc
    14941 tttctatttt atttttattc tgtagtaaca atctttttaa cttcatttgc taaatgggat
    15001 tatacaaatt taaacacccc tgagtttctt ggatttgata aattatttga aaattatagg
    15061 tatgttttta aagaataccc attttttaca gaagctctaa ttaattctgt tcgttgggct
    15121 gtaattggtg ttattattca agttccttta gctgtatctg ttgcaattac attatctaag
    15181 aaattaaaag gctggaagat atctaggaat ctttatattg taccaagtat catttctagt
    15241 gctgctatgg gcttgatttt tcttcaaatc tataatccaa actatggtgt tgttaaccaa
    15301 attattcatc tatttaatcc atcgtttaaa gattcagtac tgttgactcc aggattaaat
    15361 atagtagcta tgactggcgc ttatatcttc tttgcaggag catcaaccat tatgattctt
    15421 gggcaaattt ttgctattcc agaagaagtt caagaagctg ctattttaga caatattact
    15481 ggttggagga aagagtggta tattacgatt ccgatgatta aggggacaat taaaactgtt
    15541 tcaattatgg cagcaacttc agggtttttg ctctataacg aagtattctt tttgacaaat
    15601 ggtgctgcag gaacaaaaag tatcagtttt gttattcgag aattagcagt ggctagctca
    15661 cgaactcagt atgctcgtgc aaatacaatt ggagttatac aaatcttagg tggaatgttg
    15721 attatcgttt gtattaatat tttattcaga gaaagaaaaa gactgaaagg tgggaaatga
    15781 ttatgaatac acatataaat ggtattagta aaaaaggcaa agttcttata tatggttata
    15841 tgctccttac cattttaatt tctattttcc ctattgcgtg gattttttta tcatcattaa
    15901 aagcagatcc tatgaaaaat ccaggtatta gtttaccgac tgactttact cttgaaggtt
    15961 atataaatgt ttttacaaaa cttcatgttt tcacttactt ttggaatagc tttaaagtag
    16021 tgtctatatc agttattatt agcattgtta tgatctccat gtcttcatat gttattgcta
    16081 ggatggaatt tagagggaag aagttggtga cttctatgct gtattctact ctatttattc
    16141 cagcaacagc tatgactttt ccagtttata gattagtaaa tgagttgggg atttataata
    16201 ccccagttgc tctaattctg gtctactctt gtagtggaat tgctatgagt ttctttatta
    16261 taaagaacta ttttgaaatt attccaaaag aattggagga ggcagcagag attgatggtg
    16321 cgacatatgc tcaaactttt tggaaagtga tgttgccaat tgctagacca ggaattttaa
    16381 cagcagcagt acttgccttt attaacaact ggaatgaata ttattgggca tctatgttgg
    16441 tgattgataa aaatgaatta acagtaccag cattactagg tcaatttact acaagtttta
    16501 atactaatta taatggtcta ttttcagcta ttgttgtaat cgtattacca ccaatcattc
    16561 tattcgcatt tacaagtaaa tacttcattg aagctttagg aggaggagca gtaaaaggat
    16621 gaaacataca cttgaaacta tcaatagtag aactcagtgg tttagagaag caagatttgg
    16681 gatgttcatt cattgggggt tatattctat tccaggaaaa ggggaatgga ttcgtagtca
    16741 tcagaaatta tctattgaag attatgaacc atattttcga gcttttgatc ctaaggaata
    16801 taaccctaga gaatgggcta aacaagcaaa agctgcaggg atgaagtata tggttttaac
    16861 ggctaaacat catgatgggt tttgtttgtt tgattcaaaa tttacagatt ataaagcaac
    16921 aaatacacct gcaggtagag atttagttaa agaatttgta gatgctgttc gagctgaagg
    16981 tttaaaagta ggcttatatt ttagtttgat tgactggcac catcctgatt tccctaaata
    17041 tgctgatcta aatcatccaa tgagaggaaa tgaagcctat cgagatgaga aaattaactt
    17101 tgacagttat ttggagtatt tgcacaatca agttaaagaa attgtaactg gttatggtca
    17161 gattgacata ttatggtttg attattctta tgaagacatg gtgggtgaaa aatggggagc
    17221 ttcaaaatta atagacatgg ttcgtcatta tcagccaaac gttatcgtag ataatagatt
    17281 agaaacatca ggtgaaggat tcggaagtat cgttacagat gaaattacct cttacgctgg
    17341 agattttgtt agtccagagc aaattgttcc tcacgaaggt attcgaaact ttaaaggtga
    17401 acctgttcct tgggaacttt gtctaactat gaataacaat tgggcttata atcctacaga
    17461 ttatctatat aagtctagtc aaactttgat aagaaagtta gtggaatgtg ttagtaaaaa
    17521 cggaaatatg attcttaatg taggcccaga tgctttggga agaattaatg attcaagtaa
    17581 gaaaatatta gataattttc atcgatggat gtctcgaaat ggtgaggcaa tttatggatg
    17641 tagtggagat gaaaatttac caaaaccaga ttggggatac tatactcgta atggaaatac
    17701 ggtttatgct catgtatttg aacaacctat aggtccttta gctcttcttg gtattagtaa
    17761 agaaaacgta aaaagaatga gctttcttca tgatggaagt gaggtgaaaa tttcagaaag
    17821 ctggacgacc aatgcctaca aaggaatttg ttttgcacag tttggagaag ttccacattt
    17881 tacctatcca ttaccagact tgattgatag cgtaatcaaa attgagttga gagagtagtt
    17941 tatatgaaaa ttgaaaataa aaatgtaaga cgtaatttct tttggggaga tggtcgattt
    18001 tatactactg atatcgtaaa caaacgggca ggagtaatga taaaaaatgt ttcgaaagaa
    18061 gaatttacca ttacattgga gaatggtata agactttctt caaatcattt ttcagcaatc
    18121 gttagggaag agggagatac gcgaattcag gtttcttttg tttgtccttc cattcgttta
    18181 cgtttaatct ttgaatcgag ggatgatgtt ctttcgaagc aattagtttt agaatcatct
    18241 actgaggtta ttaaatctgt agaggtagag agttttgagt ttgaaacaga agacaatatt
    18301 ttctatccga aaagacaaga ttgtattaag gaaatggcga atttttccgg ttattatgta
    18361 gaattgggac aacctgttta tgcgaattct ttattcttag gaatggaatt tccaatgtct
    18421 gaaaacaagg tagatggtag acactatgta tcaagatatt acttgggaac tgttgtaaat
    18481 caagaaaaga gtttgtggtc ttgtattatt gggggagcat gctcttataa aaaagaagag
    18541 attcaagagg cattttttga atatgttgaa ggaatagctc aacctagtta tttccgtaaa
    18601 cagtataatt cctggtatga ccatatgacc gatattacag aggaaggtat tctaaaaagt
    18661 ttttctgaga ttcgagatgg atttgaaaat catggagttc atttagatgc ttatgttgtt
    18721 gatgatggtt ggacaaacta tcaatcagtt tgggaattca atcataaatt cccaaatggt
    18781 ttgagaaata ttaaacatct tgtaaatgga tttggttcaa gcctaggatt gtggattggt
    18841 ccccgaggtg gttataatgg gacagaaatc attatgagtg attggttaga agcacatcca
    18901 gagttaaata ttggatctaa aaatttgatt tcaaatgatg taaacgtggc tgattttaac
    18961 tatctcaatc aaatgaagaa aaagatgttg gaatatcaaa aagaattcga tatcagctat
    19021 tggaaaattg atggttggtt acttcaacct gacaaacctg ataagagtgg accgcacggt
    19081 atgtatacca tgacagcggt ttatgagttc ttaattcaac tgttgataga tctaagaaag
    19141 gagagaggag gaaaagattg ttggttaaac ttgacttctt atgtaaatcc tagtccatgg
    19201 tttttacagt gggtcaatag tttatggatt caaatatctc aagatgtagg ctttacagag
    19261 aatgcaggta atgatatcaa tcgtatgatt acttaccgag atagtcagta tcaagaattt
    19321 ttggaaaaac gtgagataca gttacctatg tggtcgcttt ataatcatga accaatctat
    19381 gctgtcagtg caaatacctg gtacatggat catcaaatgt ttgcatcaat accagatttt
    19441 gaagcttatc tattatttat ttcaacaaga gggaatgctt tttgggagtt tcactattct
    19501 tttgatatgt ttgatgaaga acgctggaaa gccaatgctc gtgccgtcaa atggatagag
    19561 gagaattatc aaacactaaa atatagtaaa aaaataggag gaagtcctga aaaatttgaa
    19621 atttatggtt ataagtgtca caatcagaag acttctactg aaattctctc tctgagaaat
    19681 cctgctcaga ttaaacaaaa aataaaaata gagaatcttt cgatagagaa ttttaccaga
    19741 gtaattggag attttactat tcaagaagat gagatagaat tggcaccgta ctctatcgtg
    19801 atactgaaga aataaagaaa aaattgtgag gtagagatga cgatttatat taataaggac
    19861 gagaccgttt ttcatttggc aatgaaagat agtagttata tttttagaat tttagaaaat
    19921 ggggaacttc aacatctaca ttttgggaaa aggattcatg tcaaggaaaa ttataaccaa
    19981 ttgatggcct atgaaaaaag aggatttgaa gtatcttttt ctgaagaatt tgaggatatt
    20041 caacagtcta tgatacaaaa tgaatattct tcatatggga aaggagattt tcggcatcca
    20101 gcctttcaag ttcaaggaat gaatggtagt aggataacga cactaaaata tcaaggtttt
    20161 gaacttgaaa aagggaaaaa tcgtcttaac tctctacctt caacatttga tgatattggt
    20221 cagtgtgcgg aaacattaac gattatttta acagattcca tattagattt aactgttaga
    20281 ctaaattaca caatttttcc ggaatacaat gtcttagtta gaaatacgga atttttaaat
    20341 aatagcaata ataagttgac tcttttgaaa gcaatgagct tacagctaga tctacctgat
    20401 agtcaatatg actttattca attttctgga gcatggctga gggaacgtca gttatataga
    20461 acttcgctta gaccaggtat tcaagcaata gatagcttga gatactcatc aagtcctcag
    20521 caaaatcctt tctttatgct atcaaggagg gaaactacag agcatagtgg tgaggtttat
    20581 ggttttaact ttatctattc tggaaatttt caaaatatga ttgaagttga ccattttgac
    20641 accgctagag taacggtagg aataaatcca gtagaatttc gttttttatt aaatcctgcc
    20701 gaaagttttg tgacaccaga agcaattgtg atctattctg atcaagggat gaatcagatg
    20761 agccaacaac tatcagattt ttatcgacat catttagtta atcctaattt ttctcaagct
    20821 agtcgtccta taatactcaa tagttgggaa acattttatt ttgacttgag tacagaaaaa
    20881 attttagatt tagcaaaggc tgctaaagat ttagggatag aattatttgt actggatgat
    20941 ggttggtttg gtcataggaa agatgacaaa agttctctgg gtgattgggt aacagataga
    21001 agtcgtcttc ctgaaggtat tggatttctt gcagatgaaa ttcacaaaat aggtttacaa
    21061 tttggtttgt ggtttgagcc tgaaatgatt tctattgata gtgatttgta caagaatcat
    21121 gccgattgga ctatccattt gttagacaga gagaagtcag taggaagaaa tcaatatgtg
    21181 ttggatttga cgagacagga agttgttgat tatctttttg attctatttc taaaatcata
    21241 atcaaaacaa atctggatta tatcaaatgg gatatgaatc gtcatataac agatatttat
    21301 agtattgaac ttgattctga acagcagatg gaatttggtc atcgatatat cttaggtctt
    21361 tatcagttat tagatcgttt aataactaag ttcccttcag ttctatttga atcttgttct
    21421 tcaggtggtg gacgttttga tttaggactt atgtattatg caccgcaagc gtggacgagt
    21481 gatgatacgg acccgataga aagattgaaa attcagcatg gaacttctta tggatattct
    21541 ccatcaatga tgacagccca tgtttctatt tctccaaatg aacaaagtgg aagacaaacg
    21601 agtttggaca ctaggacaaa tgtagcttat tttagttctt tcggttatga attagatgtt
    21661 acgagattgt cggtagaaga aaaagaacaa gtgagagaac aaattcagtt ttataaaaaa
    21721 tatcgttcat tgtttcaata tggggatttc tataggataa acagtccttt tagttgtgat
    21781 tctgctagtt ggcaagttgt ttcaaaagat aaatgccaat cgattttatt gtatgctcaa
    21841 ttgaatagta agttgaatcc aggttataca agagtttatt ttagtggttt agataaagat
    21901 aaatgctatt ccgtctctgg atttgatgag ttcttttatg gagatgaatt aatgaatgct
    21961 ggaataaaag taagtttaag taatttagca ctttgtgttc cagaatatct tacaaaatta
    22021 tttgttattg aggaagttgt atgtaaatat tgaggaaata aaaatggaaa gtaaaaaaat
    22081 agcaaaacag attttaatag ctacggctgt tttaacaagt tttttaggaa gtaatttggt
    22141 ttatgcagat gtagttcaaa gtaattctaa taacagagct agtactgaaa ctgctagagt
    22201 aacagggaat aacttagaaa aacttattac taaaggtaaa gaaattgata aagagatgac
    22261 atatctttca gatatggatt ggtcttctgc aactcatggt gatatagata aaacaaaaac
    22321 agtacaaaaa gatgctccat ttacaacagg aaataaagga gagcatacta agatttcatt
    22381 gcttacttct gacaataaag ttaagtattt tgataaagga atagggacag tcgcagattc
    22441 cccgtctgta atcagctatg atattagtgg tcaaggattt gaaaaatttg aaacttatat
    22501 aggaattgat caaagtgcta atagttctag atcagaccac gcagtagtgg ataaaataga
    22561 aatagatgga aaggttgtct attctagtag tgtaactaat ccagaaggat tcagatataa
    22621 tacccaggca caatttatta gtgtgacaat tccacaaaac gctaaaaaaa tatccttaaa
    22681 atcattcgca ggagaacata catggggtga tgaagttgta tttgctgatg ctaaacttat
    22741 taaaactgtt agtactcaaa ctataactcc agatcttctt aataaaggaa ttaatggagg
    22801 agtatatctt tctgatttag aatgggttga tgctactcat ggtgatgacg ataaatcaaa
    22861 aacagttcag aaagataaac cgtttacacc tggtaataac gggtctaata ataaaataaa
    22921 attactaatt gacggtaagg aagtcgaatt taataaggga ttgggaactg tagcaagtaa
    22981 cccgtctagt ataaaatatg atgtttcggg tgctaatgtt acaagattta tttcctatgt
    23041 cggaattgat aggagtgcca atcatttaaa ttcagattac gcagatattc aaaaatttga
    23101 agttgttgcg gatggtaaag tcatttactc atcagattca aaatatccaa aaggaattaa
    23161 gtatgataca tcggcatttc tggttgatgt tgaaattccc aaagatacac agacaataga
    23221 acttaaatca tattcaggga aacatacatg ggctgacgaa ttggttttag gtggagcctt
    23281 gtttatggca aatggtaaat ttaagaatcc taatgattgg tcagaagttg ataaacgtcg
    23341 tgaaattaat aatgaacatc cgttacttat gatgccttta tatgctaacg gagaagagtt
    23401 taaccaaggg aaatatactt tttggggagg agatacatta acaggtaagt gggagaatat
    23461 accagatgac ttaaaaccat atactgttat acagttacat ccagatgatc ttcctaaaag
    23521 agatggagct gctagagatt tttatgaaca tatgttagaa gaagcagcga aatatgtaaa
    23581 tcctaagact ggaaaaaatg aaccaattcc agttattctg acggtttaca ctgctggtaa
    23641 tatgccttat tatacttcgg cacattggtt aagtaccagc tggattgata aaatgtatca
    23701 aaaatatcca aatttgcatg gtattttcag tacagagaat tattggattt gggcaaatga
    23761 tattgaaaat aaggcggcag attacttaaa agtatcagct aaaaatggag gatattttat
    23821 atgggctgaa caaaataatg gttctgcaat agaaaaagca tttggaaaaa acggtaagat
    23881 agcatttcag aaatctgttg ataagtactg gaagaacctt attttcatgt tcaaaaatac
    23941 acctgctgct gagggaaatg attcaactac agaaagttat atgaagggac tttggctttc
    24001 aaatcatact tatcaatggg gtggtttgat ggatacttgg aagtggtatg agacaggtaa
    24061 atggaaactg tttgcaagtg gtaatatcgg aaaaagtcaa ggagatagac aatggttgac
    24121 tgaaccagag tctatgctag gagaagaagc tttaggggtt taccttaatg gaggtgtagt
    24181 ttataatttt gaacacccag cttataccta tggtgtaaat aataaagaaa gcttactctt
    24241 tagcgaagta ataaaagaat tttttagata tgtaatagcg catccagcac catccaaaga
    24301 aaaggtactt gaggatacaa aagtattcat acatggagac tattcaaata aaggaaatgg
    24361 taagttcttt gtaaacgtaa atactgatag agaacaaact ccattataca tgactggtcg
    24421 ttataatgtt attccagcta ttccaggtgt tttaaaaaca gataaattga aagagtctgt
    24481 ttctggtagc cgtattcaga ttaaggaaat cacttctcca gaatttagct ctactcaggc
    24541 tagaaaagaa tacttaaata agctgtatcc tatgaattat gaaggagata tctttgctca
    24601 gaaattagat aatagatggt ttgtctataa ttataaggta aatgagaatg ttaaacagac
    24661 tgggaaatta aaatttaatt ctttagaaat ggatgttgaa tttgaacctc atacctatgg
    24721 tatttttgag agaataagta atggattgaa agtgaattta aataatttta gaacaaataa
    24781 agattcacta tggtctaatg ctcaagatgc aaatcaggca aagaaactac cacaattgac
    24841 caagaaaggt gcgattaagt ggattgaaga acattatatc aaagatactc agtttggaga
    24901 gaaaagggtt acaaagatag tattaagagg tatagataaa cttcctacta ttcattcatt
    24961 atcaggaaca aataattcct atgatcagcc atctctcaat tttgatcaga aaaatcatat
    25021 ggttactatt accattaaca gtaacggaaa tcttgaattc gaacttcatt tttagaaagg
    25081 agtgagttta tgtctcaaga tgaaaaatta attcgtgaac agatttgtga tgtttgtcat
    25141 aagatgtggc aacttggttg ggttgctgct aacgatggga atgtatctgt tcgattagat
    25201 gaggatacca ttcttgcaac acctactggt atcagcaaaa gttttattac accagaaaag
    25261 ctggtgaagt taaatcttaa aggagagatt ttagaagcag aaggtgatta ctgtccttct
    25321 agtgaaatta aaatgcacat tcggtgctac gaagaacgtg aggatgtccg ttcagttgtt
    25381 cacgcgcatc caccgattgc aacaggattt gctcttgcac acattccttt agatacttat
    25441 tcactaattg agagcgcgat tgtggtaggg gcaattccta taacgccatt tggagttccg
    25501 tctacaatgg aagtgccaga agcaattaca ccttatctgc ccgatcatga tgtcatgcta
    25561 ttagaaaatc atggagctct gactgtcgga agcgatgtca ttacagcata ctaccgtatg
    25621 gaaactttag aattagtcgc aaagacaacc ttccacggaa gaatgttact ttctacaaag
    25681 ggcattgagg agcaagaaat tgctcgtccg actttagaac gtctattctc aatgcgagaa
    25741 aattataagg ttacaggtcg tcacccaggc taccgtaaat ataatggaga tggtagtatg
    25801 aaagaaacag aaaaataaga ggaaaatagt atgattcaac atccacgtat tgggattcgt
    25861 ccgactattg atggtcgtcg tcaaggtgta cgcgaatcac ttgaagtaca aacaatgaac
    25921 atggctaaaa gtgtggcaga tttgatttca agcacattga aatatccaga tggggaacct
    25981 gtggaatgtg tgatttctcc atctaccatt ggtcgtgttc cagaggctgc agcttcccat
    26041 gagttgttta aaaaatcaaa tgtttgcgca acaattacag ttacaccatg ctggtgttat
    26101 ggtagtgaaa ctatggatat gtctccagat attcctcatg ctatttgggg atttaatggg
    26161 acagaacgcc caggagctgt ctatcttgca gctgtactag cttcacatgc tcaaaaaggg
    26221 attccagcct ttgggattta tggtagagat gttcaggaag ctaatgatac agatattcca
    26281 gaagatgtca aagaaaaact tttacgttat gcgcgtgcag ctcttgcaac tggcttgatg
    26341 agagacactg cttacctatc aatgggtagt gtttcgatgg ggattggcgg ttctattgta
    26401 aatccagatt tcttccaaga atacttagga atgcgaaatg aatcggtaga tatgacggag
    26461 ttcacgcgcc gtatggaccg tggtatttat gacccagaag agttcgaacg tgctatggtt
    26521 tgggtaaaag aacatatcaa agaaggggtt gaccgaaatc gtgaggattt gattctttct
    26581 aaagaagaga aagaaaaaca atgggaattt gttattaaga tgttcatgat tggacgtgac
    26641 ttaatggttg gtaacccaag acttgctgaa cttggttttg aggaagaagc ggttggtcac
    26701 catgctttag tagctggttt ccaaggtcaa cgtcagtgga cagaccattt tccaaatgga
    26761 gattttatgg aaactttcct caatactcag tttgactgga atggtattcg aaaaccattt
    26821 gtatttgcga cagagaatga ttcactaaat ggtgtgtcta tgctctttaa ttatctatta
    26881 acaaatactc cacaaatctt tgctgatgtg cgtacttatt ggagcccaga ggctgttaaa
    26941 cgtgtaacgg gacatacttt agagggtcgt gctgcagctg gcttcttaca tctaatcaac
    27001 tctggttctt gtacattgga tggtacaggt caagctactc gagatggcaa acctgttatg
    27061 aaaccattct gggagttgga agaaagtgaa gtgcaggcta tgcttgaaaa tacagacttc
    27121 ccaccagcaa accgcgaata cttccgtgga ggaggattct caactcgttt cttgacgaag
    27181 ggggatatgc cagtaacaat ggtacgtctc aatcttctaa aaggggttgg tccagtgcta
    27241 caaattgcag aaggttatac acttgaactt cctgaagatg ttcaccatac tttagataat
    27301 cgtacagatc caggatggcc aactacttgg tttgctccac gtttgacagg aaaaggtgct
    27361 ttcaagtctg tctatgacgt catgaataat tggggagcta atcacggagc cataacatat
    27421 ggacacattg gagcagactt gattaccttg gcttctatgt tgagaattcc tgtcaatatg
    27481 cataatgtac ctgaggaaga tatctttaga cctaaaaatt ggtccttatt tggaacagaa
    27541 gatctagaat cagcagacta tcgtgcatgt cagttgttgg gaccactaca taaataaaac
    27601 ttgtttatat aggaggtgaa cttacgtccc tcctatcctt ttaaaaagat ttgttaaaca
    27661 attcacaaat aattgaaaac gaatacaaaa agtaatataa tgatgttaaa tagatagcgc
    27721 aaaggcgcag gaggaaaatt atatggctac attttatgtt ccggcagtca accttattgg
    27781 taaaggtgtt gtaaatgaag tgggtcctta tatcaaggaa cttggctata aaaaggcact
    27841 tttggtgaca gataagtaca tcgaaggcag tgacatttta cctaaggttt taaaaccact
    27901 ggatacagaa ggaatcgaat atgtcatctt tagcgatgta gagccaaacc ctacttgtaa
    27961 gaatgtcaca gatggggtag ctgctttgca agaacatgga tgtgatttta tcatcagtct
    28021 tggtgggggt tctccacagg atgcagctag ttgtatttct atcatggcta caaatggtgg
    28081 aagaccacag gattatgaag ggcttcataa gtctgctaaa aaaggcttgc cagttgtggc
    28141 tatcaataca acggcaggaa cttctgcaga aatcactatt aactatgtga ttactgatga
    28201 agaacgcaag gttaagatgg taatggttga caagaatagc cttgctctta tctctgtcaa
    28261 tgacccggaa ctcatgcttt ccaaacctca agccttgact gctgctactg gtatggatgc
    28321 tctgactcac gctgttgaag ctttggtaac acctggtgct tatgatgtaa ccaagaaact
    28381 gtctattggt gctattgagc ttatcaagga atatcttcct cgtgctgtag aaaatggaca
    28441 tgatattgaa gcgcgtgaag gtatggtcaa tgccatcttc cttggtggta tgagctttaa
    28501 taatgctggt cttggttatg ttcactcaat ggctcaccaa ctcggtgcag tatataattt
    28561 gccacatggt gtttgctgtg ccatgttgct accagttata gagcgtgaaa atgctaaacg
    28621 tgtaccagaa gctttccgca atgttgccaa agccttggga cttcatgtag aaggtaaatc
    28681 agatcaagaa tgtgccgatt atgcgattgc tgagattgag aagctttctg agacagtagg
    28741 tattcctaag aaattgactg aacttggtat tgaagaaaaa gatttcgact ttgaatacct
    28801 ttctaagaat gccttgattg atgcctgcgc accaggaaat ccatttatgc caaccttaga
    28861 agaaacgatt gccttttata aagagttatt ttagcaagag attagacgac aataggacaa
    28921 ttcacctcta attattgaca tttcaggaaa aatcgcagta aaaacggcac agccttcttt
    28981 aaatgtgcta taatactaga aaaatacttg tggaggttcc attatggcaa tatttttcat
    29041 gatttttctg attgtttgtg tgctcctatt ggtgatagtc acactgagta cagtttatgt
    29101 ggttcgtcag cagtcggtgg cgattattga acgctttggg aaataccaaa aggttgctaa
    29161 tagcggtatt catattcgct tgccttttgg gattgactcg attgcagcac ggattcagtt
    29221 gcgcttgttg caaagtgata ttgtggttga gactaagacc aaggacaatg tgttcgttat
    29281 gatgaatgta gcgactcagt accgtgtcaa cgagcagagc gtgacagatg cctactataa
    29341 actcatacgt ccagaatctc agattaaatc ttatatcgaa gatgctcttc gctcttctgt
    29401 tccaaaatta accttggatg aattgtttga gaaaaaagat gagattgccc ttgaggttca
    29461 acaccaagta gcagaagaaa tgaccactta cggctacatt atcgtgaaaa ccttgattac
    29521 caaggtcgaa ccggatgcag aagttaagca atccatgaat gaaatcaatg cggcgcaacg
    29581 taagcgggtc gcagcacaag aattggcgga agctgacaag attaaaattg tcactgcagc
    29641 tgaagcagaa gcagaaaaag accgccttca tggtgtgggg attgcccaac aacgtaaggc
    29701 gattgtggat ggattggcag agtctatcac cgaactcaag gaagccaatg ttggcatgac
    29761 agaagaacaa atcatgtcta tcctcttgac caaccagtat ttggatacct tgaatacctt
    29821 tgcctctaaa ggaaatcaaa ctatcttttt accaaatact ccaaatggtg tggatgatat
    29881 ccgaacacaa atcttgtcag cccttcgcgc tgagaagaaa taatagacta atactcttcg
    29941 aaaatctctt caaaccacgt cagcgtcgcc ttgccgtata gatgttactg actttgtcag
    30001 ttctatctgc aacctcaaaa cagtgttttg agctgacttc gtcagttcta tctgcaacct
    30061 caaaacagtg ttttgagctg acttcgtcag tcttatctac tacctcaaaa cggtgttttg
    30121 agcaacctgt ggctagtttc ctagtttgct ctttgatttt cattgagtac aaagagcttg
    30181 gcaacaggct ctttttgtat tgcgtttatt aagaaaaaca aaaaacatcg atatacattt
    30241 aactaaaaat tattgtatgt tatctccctt aattaggaat gataagggaa taactagaaa
    30301 gatttgtgaa tacaaactat ttctgatata caaaatatac agtaataatg aatgatggga
    30361 gatgggatga aagaatttca atttgagaga aagcagcgtt tttctttgag gaaatatgca
    30421 ataggagctt gttcggtctt gctaggaacg agtttatttt ttgctggtat gggtgatcag
    30481 cctgtacagg atacagaaac gagttcagca ctaatttcaa gtcattattt ggatgagcag
    30541 gatttatctg aaaagctgaa atctgagttg caatggtttg aattagaaaa caagcttttg
    30601 aacttatggg agcattaggt tactatgaag gatttgttcc ttatgtttca aatcaataca
    30661 aaaaccaagc tgaagaagaa ggcaaaccgc tatctgataa atatattttc gaaaaaatct
    30721 taggaaaaac atatgcagcc tttaaaaaag atcaaattaa tgagcgtgtc gagaaattag
    30781 gtaagttaaa acctattaca ataaattaca acggaaaatc agaagtaatt gatagtaaag
    30841 aaaaattaca agagcttatg aataaagccg ttaaagacga agtggctcaa atatagtaaa
    30901 atgaaataag aataggacaa atcgttcagg acagtcaaat cgatttctaa aaatgtttta
    30961 gaagtagagg tgtactattc tagtttcaat atactataaa atcaggcaat accacggcta
    31021 aaaagtttga gtttatcgaa acaccagtgc aaaaactgaa aaaatcgatt tataaagctc
    31081 atctcaaaga ttcagatgac tttagaccag aaacatccac ataaatcttt ttgaaagctg
    31141 tttgaagctt tgtccttgct ttcttagttc atagatctga actttatctt cataactcaa
    31201 tttcataata aaacacccca aaagttagat ttattctgtc taacttttgg ggtgcagttc
    31261 attaatcggt cgattttttt ggtagaaaca gttgcctgat taagttgcaa gtcgatagac
    31321 ggcttcggca taaatatcca tagcacggta caaatcttct agaacggcac attcatttgc
    31381 ctgatgttct gtctgcttcg ctcctgggaa taaggcgccg aaggctacac aatttggcat
    31441 ggtgcgagca aaagtggcac caccggatga aatagcagga ctgttatcgc cagtcttttc
    31501 ttggtagatt tgcatcagtg tgctaacgag tttactgtct tttgcgacgt atagaggcgc
    31561 tagatagtca aactcttcgt agcggagttg gtagttttgt gcacatcttg taagcaactc
    31621 tactagttct tccttgtcag ctaagacagg agtccgaatg tcaatacgga tttcagaacg
    31681 ttcatgattg atcatgagac ctgcgacatt aaaggatagg tgaccagaag gttcatctgc
    31741 tatatcacca aagatttgtc ttcctgtgcc gtcttgacct gcttgtgttg caagaaaact
    31801 gagagcaggg tgttcttgga gaggagcaag aatggtagct agtcggatga cagcattgat
    31861 accttgacta gcatccttag catgctttgg cactccgaga accgttacgg tttgttcagt
    31921 ggtttggtaa tcataaccag cttctttgag accgttacaa acctgttcat agaggggacc
    31981 ttggtagttg gccttgtctg gtacaacgtt aaaggcgcct cctacttcaa gctctagttg
    32041 atccgatcca gggccataaa gtttgacctg tagaagccct ttttcagcat aggtcagagg
    32101 aaaagatgag tcaggtgcaa agcccatgct ggcctgttct tcgatggtat tgtagcgtgc
    32161 catgcagcgc cagagggttt cctcatcggt accaaagata aagcgtacgc gctttttgaa
    32221 ctgaatacct tggtccagca agctttttac tgcatagaga gctgcgagcg aagggccttt
    32281 atcatcttgg acaccacgtc cgaataccca gccgtctttg atagttgctt caaatggcgg
    32341 tgtctgccaa tctgcttcat cacctgatgg aacaacatcc aaatgacaga gaatggccag
    32401 aagctctgct ccctgaccga tttctgcata tccgtaataa cctttagggt caagataggt
    32461 agtgaaacct atgtctcgac aaatctctaa agttttttct aggacatctt ggattgcttg
    32521 tccaaaaggt gttccatttt ctccttcatt gagtactgaa ggataggaaa tcaaggtttt
    32581 taatgatata agaaattcat ctttaacttg atttgttata tctattttca tggaatcacc
    32641 tcactcacta ttttatagga atggaaggaa ggttccaagg agaagaaggg cgatggtcac
    32701 tacaataata gcgactacga gtttgcccat gaatttccac caagtaccaa tgttgatacg
    32761 tccaagtgca agagctccca tcacaatacc agatgttggt gcaatcaagt tcaagacacc
    32821 tgaagcagat tggtaagcag tgataatcaa gctaggacgg acatttacaa attctccaag
    32881 tggagccatg atacccatag ttgcgctggc aagaccagat gaagatggga tcaagaatga
    32941 cataggtaga tagaagatat aagttacaac gataaagact tgtgaagata gaccgctcaa
    33001 gccttcttta ccccagttga ggattgtatc ggtaatcata ccgtcgttca tgataacttg
    33061 aataccacga gcaatcgcta cgatcaaggc aacactgagc aagtcagcag caccattcat
    33121 gaaggaagag ataatcttat cttctttaag accataaata acaccaatca ggatacccat
    33181 aaaggcaaag agcattgcgc cttctgggaa gtaccaagta cctagtgcag aagtagatga
    33241 accgacaata ttaccaataa ctggaagacc agtcaaccaa gcattaaagt catcaaaaat
    33301 ggtaacgcca aggtctgtcc atggaatgaa gctcaatacc atcaagatga atgtcaacac
    33361 aaataagaag agaactgatt tttgtttgct gctaagtgta gattctacag atgaagattc
    33421 ttctacgtta aagtgtttca aatcttcttt gcgagtacta taaaccagtg acttagtcgg
    33481 atctttttga atcttatccg cataacggta aacaaaccaa gtactaagag cagtcaaggt
    33541 aacccagaag atcagacgaa gtacgatacc gtcccctgta ccaactcccg cagtcgctga
    33601 agcaatacct gtcgcaaatg gattcagagt agatgccaaa cagccgattt gagaaccgag
    33661 caaaataatt gcaacaccag tcaggctatc aaaaccaacg gccatcataa ctggcacaag
    33721 gagtggatag aaggccattg tttcttcacc cataccataa gttgtaccac cgagggcaaa
    33781 caaaggcatt agtaccaaaa ttaacatttt ttcgcggccc ttatacttct tcacgataga
    33841 ggcaatccct acgtcaagag caccagtttt gttgacaatg ccaaggaaac caccaaccat
    33901 aaggatgaag aaggctacat caatcgctgc gctcgtttct ttaatgagcg aaccttcctc
    33961 tggatgagta cctagcatag cccgaatcgg tgccatgagg acatcccaaa tcccttgtgg
    34021 attttgaggc tgagtctcgt aaataccttc tataaaggcc cccgcaggga taaaccaagt
    34081 tagtactgcc ataatagcaa tgattatcaa taatacggtg taagatgaag gcatcttaaa
    34141 ccctttttta gctttttcac tcatttgttt ttcctcctga tgtctaacaa agtgtaaaaa
    34201 accaactact ttcttaaata aacatttaag aaaacgcttt ctatttatat ttgttttacc
    34261 atattaaagt ctaaaaaact aatatctttt gaaatattgt acatgttttc aagaataatt
    34321 tctaatttga tataaagata ctagaaatag aatacatctt attagtaaaa caacttatcc
    34381 tttttcaata attgttccgc tttcagattc aatcaaggcg cctagatttt caagggaagt
    34441 aataactgct tttccttctg gacgaccatt gacaaaagcg atagctgctt ctacttttgg
    34501 aagcatgcta cctggtgcaa actgatcttg tttgatatat tcttccagct gggcaacatt
    34561 cacatgttcc aatttttcct ggtttggctt gttgtagtta acaaatacat aatctacacc
    34621 tgtcaaaacg atgaagaggt ctgcatcaac caattctgcc aaacgttggg aagcgaagtc
    34681 tttatcaata accgcttcga caccagtcaa atgtccattg ttttctttga tgacgggaat
    34741 accgccacca cctgcagcta cgacgacttg accattattt aaaagagtac ggatggtttc
    34801 aatttctttg atgtcaacag gttttggtga ggcaacgacc ttacgccagc cacggccagc
    34861 atcttccttg aaagtcgctc cgctcttttc ggcttctgct tttgcttctt cttctgaata
    34921 gaaaggaccg attggtttac tcaagttaac aaaagctgga tcatttttat ctacgacaac
    34981 ttgcgttaca acagaggcaa catttttttc gatgccttca tccaagagag cattttgcaa
    35041 agcatttttc aaccagaaac cgatgctacc ttctgtcata gcgacaagtg agtcgagtgg
    35101 gaaggcaggg ttcttttcag agtctgatgc caaatgttgg agcaagagat tcccaacttg
    35161 aggtccatta ccgtgagtga taatcagatc atctccattt ttaatcaatt ttacaagatg
    35221 cttagctgtt tcaactaaag cttcttgttg agcctttgct gatgggtcag aagaaagaat
    35281 cgcatttcct cccaaagcta ctacaatttt acgatttgcc ataaattctc ctttatcaca
    35341 ctcaatagaa tgcgtttaga tttcaattta atgatttttc acatatttta taagaaataa
    35401 tagattacca ttacataaaa gaggaccgga ctaaagctat tagtcgcagc cctcatagct
    35461 gttggtagac ggtttattat ctaaaattat actttaggaa tataaaggtt accaagtgta
    35521 gcagccataa cagctttgat agtgtgcata cggttttctg cttgatcgaa gtggcgagcg
    35581 tacttgctgc ggaagacttc gtctgttact tccatttctt ctacaccaaa tttttcagca
    35641 acgtctttac cataaacagt gtgagtatcg tggaatgctg gcaagcagtg taggaagatc
    35701 aagttttcat tgcctgcttt tttaactaag tccatattga cttggtaagg tttaagaaga
    35761 gctacacgtt ctgcgaattt gtcttcttca cccattgata cccaaacgtc tgtgtaaaga
    35821 acgtctgcat ctttaactgc ttcatcagca tcttcagtga tgagaacatg tgcgccactt
    35881 tctttagcaa atccttctgc caattcaacg atttcttttt ctgggaagag ttcttttggt
    35941 gagaagatgt gaacattgac accaaggata gcacctgtta cgagcaagct gttggcaacg
    36001 ttgttacgtc catcaccaca gtataccaat gtcaagcctt ccaagcgacc gaagttttct
    36061 tgaacagtca agtagtcagc gagcatttga gttgggtgcc attcgtcagt tagaccgttc
    36121 catactggaa cgcctgagaa ttctgccaat tcttcaacca tacgttggct gaatccgcgg
    36181 aattcaatcc cgtcaaacat acgtcccaat actttagcag tatcttcagt agattctttt
    36241 ttacccaact gaatatcatt tgctccgagg tattctgggt gagcaccaag gtcgatagcc
    36301 gcagttgtaa aggctgcacg agtacgagta gatgtttttt caaataggag agcgatattc
    36361 ttgccagcaa ggtagtggtg ttgaatattg cgttttttca aatctttcaa gtgagctgaa
    36421 agaccaataa ggtattctaa ctctgcacgg gtaaagtctt tttctgctaa gaagctgcgt
    36481 ccttggaata ctgaatttgt cattttatta tttcctcttt ctatttttta cattttctat
    36541 tgacgaatac cgaacagcga ttacacttct tcacgttcaa atggcataga catacaacga
    36601 ggtccaccac ggccccgaac caattcactt ccgcgaatct taatcaagcg aagcccgtat
    36661 tcttccaaaa tcttattggt cacggtattg cggtcataaa caactaccac accaggtgcg
    36721 atggtcaaag tgttagaacc gtcgttccat tgttcacgcg cagctgctac gatattgcca
    36781 ccaccgcaac gaatcaaatg aactttttct acaccaaggt tttgagcaag aagttcagct
    36841 aagtcacctt tctcttcaac tattttaagt ttttcgtttt cgtaagtaac tgagtaaacg
    36901 tgaaggtcgc cttcgatttc tgggtgaata gtgaacttgt catagtctac catagtgaag
    36961 acagtatcca agtgcatgaa tttacggttg ttagcaaatt caaaggccaa aactttcttg
    37021 aagccaacat ttttcttgaa gatgttgacc aaaagttttt cgatagaagc tgcgtctgta
    37081 cgttgagaga tacctactgc aaggacgtct ttagaaagaa ttagctcgtc tccaccttcg
    37141 atacgcgtat cttcttcacg gttgtagacc aaatccactt ttccgccata gattgggtgg
    37201 tatttgaaga tatacttacc gtaaagtgtt tcacggttac gagtatctgc aaacatgtgg
    37261 ttaagcgata cggcgtttcc aattgttgca aatgggtcgc gagtgaaata gaggtttggc
    37321 atcgggtcaa ttgcaaatgg atactctgat tcaactaagt cagttagatc tttagcttcg
    37381 tcaggaattt ctggcaattc aactttttga atcccagcca ttgttttttc aaccaattct
    37441 tggttgtcct tgatgccgtg aagtaattca cgaatagcaa ccttggtttg acgatcacgg
    37501 atgttggctt cgtctaagta ttcctcgata aattgatcgc ggatttctgg agaggtcaat
    37561 gattcagcag cgagttgttc taggtagaga acctcaattc cttcatcgcg aagagcttgg
    37621 gcaaatgcat catgttcttt ttgagcatct tccaagaaag gaatatcatc aaaaagaagc
    37681 ctttcaagat agtccggcaa taagttttct aactccttgc ctggacggtg taacataact
    37741 tttttcagtt tcccaatttc tgagaagacc tgaattggat gtgaagacat gtattttcct
    37801 ccttaaaaat tttgacttgg caccattttg ggtaccgctt acatgtatgt tataacgcaa
    37861 ttcctaggta atgtcaatgg ctataatttc tcggaaaata atataaatta tgatatttag
    37921 cacaatttta tgttattata cacaacatag gatggaatac atatatacaa atgcataaac
    37981 ttctattaaa gaggatataa aattttttta aaaaattttt caaaaaatac acaaataacc
    38041 aaaaagtgtc caattatcat ctggttatca cttggatctg tataaagaga aatgtttgtg
    38101 tgaaaggata aaaagatgca acattctttt gaagatagat tttggagaag catttcttgt
    38161 tcaattgtac aaattataga atcttttctg agtatttagg aagagataat tatcttattg
    38221 accctctttt tattttttgt tatagtcgac gaggtgatag tttagaataa tcacttattc
    38281 acaatctgtg gaaaagtctg gagagtgaat ggtcttcaca caatgacctg aaagaagcct
    38341 gagaataatt atggagagta gcattctgag aggtgttagc agaaccatat gacagagctg
    38401 tttgaagagg gaatattgag gagcaaaatc ctgagcctac cagttggagt tggaaagagc
    38461 tggctgttag atcatggttt attatccaca acctgtggat aaccttgtga acaagagaag
    38521 ttgctaaaga aggagatata taacgatgaa gaaaatcaaa ccgcatggac cgttaccaag
    38581 tcagactcag ctagcttatc tgggagatga actagcagct tttatccact tcggtcctaa
    38641 taccttttat gaccaagaat gggggactgg acaggaggat cctgagcgct ttaacccgag
    38701 tcagttggat gcgcgtgagt gggttcgtgt gctcaaggaa acgggcttca aaaagttgat
    38761 tttggtggtc aagcaccacg atggctttgt cctttatccg acagctcaca cagattattc
    38821 ggttaaggtc agtccttgga ggagaggaaa gggcgacttg ctccttgaag tatcccaagc
    38881 tgccacagag tttgatatgg atatgggggt ctacctgtca ccgtgggatg cccatagtct
    38941 cctctatcat gtggaccgag aagcggacta caatgcctat tatctggctc agctgaagga
    39001 aatcttatca aatcctgcct atggaaatgg agggaaattt gctgaggttt ggatggatgg
    39061 tgccagagga gagggcgcgc aaaaggttaa ttatgaattt gaaaaatggt ttgaaaccat
    39121 tcgtgacctg cagggcaatt gcttgatttt ttcaacagaa ggcaccagta tccgatggat
    39181 tggaaatgaa cgagggtatg caggtgatcc actgtggcaa aaggtgaatc ctgataaact
    39241 aggaacagaa gcagagctgg actatcttca gcacggggat ccctcgggca cgattttttc
    39301 aatcggagag gcagatgttt ccatccgtcc aggctggttc taccatgagg atcaggatcc
    39361 taagtctctc gaggagttgg tcgaaatcta ctttcactca gtagggcgag gaactccact
    39421 cttgcttaat attccgccga atcaagctgg gctctttgat gcaaaggata ttgaacgact
    39481 ttatgaattt gtgacctatc gcaatgagct ctataaagaa gatttggctc tgggagctga
    39541 ggtatctggt ccaactcttt ccgcagactt tgcttgtcgc catttgacag acggccttga
    39601 gaccagctct tgggcaagcg atgcagactt gcccatccag ttagaactcg acttaggttc
    39661 tcctaaaact tttgatgtaa ttgagttgag agaagatttg aagttaggcc aacgtatttc
    39721 tgctttccat gtgcaagtag aggtggatgg tgtctggcag gaatttggca ggggcttcac
    39781 agttggtcat aagcgcctct tgcgaggtcc gctagtagag gcacagaagg tgcgcgtgat
    39841 gattaccgag gcacaatcta ttcctgtatt gaccaagatt tccctttata aaactcctgg
    39901 attatcaaaa aaagaagttg ttcaggaact agcatttgca gaaaaaagcc tagctgtggc
    39961 aaagggagag actcttcatt ttaggattga acgtagtgaa agtagctcct ctttagaggc
    40021 taagatttcg attcaaccgg ggacaggtgt ccatggtgtc gcctatcagg atgagattca
    40081 agtccttgcg tttcaagctg gtgagactga aaaaagtctg acgctaccaa ccttgtattt
    40141 cgcaggagat aaaaccttgg atttctatct gaacctaacg gtggatggtc agcttgtgga
    40201 tcaacttcaa gtccaagttt cataaaagaa gaacctttgc gcgatgcaaa ggttcttttg
    40261 gttattagtg acttggtaac cagctgaggg tgaaagttag ttgttcagct tttaagaggt
    40321 cttggtgttg aatagttgat acgagtgttt tgtccagtcg gcattctttg acaaagttaa
    40381 aatggttgtg gttttgttta gtatggatat ccagccattt atcttcttta gcgaggtaga
    40441 ctcgtagatg gtcaaagaga gggattccga ggtcatagct tggttttcct ggacaggttg
    40501 gataaaatcc gagagctgac cagatgtacc aagcagagag actaccattg tcttcatctc
    40561 caggataggc ttcccaactt gggtgaaaag ctttctgacg gagcgtcttg ataagaaggg
    40621 cagtgtagtc agggtaatcg ctgtaacgga agagataagg aatgtggaaa ctaggctggt
    40681 tggaaatggc tatttgtcca aaaggagcag tagccatctc gctcatttcg tgaatttcgt
    40741 aaccatagcc tgttatttca aagaggggag catcttgaca ggttttcaaa agatagttgc
    40801 taaaggtttc ttttccaccc atcagttgga ttaagccagg gatgtcgtgg agaacgccta
    40861 aagtagcttg aatggcagag cattcagcgt agtctcgccc ccaactataa ggagagaagt
    40921 cagggtgaaa gtttccttga ttgtctcgtg ctcgcatgta acctgtctca gcgtcaaata
    40981 gctggcggta attttgtgaa gcagccttgt aggtttcagc gatttctatg ttctctagtt
    41041 ttttggcaca gctggcgata caaaagtcac tataggcata gtctagagta tggctaacac
    41101 tttcatggtg gtcggtagag aggtaaccta gttcttggta ttgggctagt ccgtggcggc
    41161 cattgattcc gagagggtcg gctttgctgg ctgtttcgag catggcttgg aagagttctc
    41221 cttctaggtc gggggccatg tccttgcagg tgctatctgc gataataccg tctaaaagtg
    41281 tacctggcat catacctcgt tcatctggag ccagccattt tggaaggaaa ccagtatcgc
    41341 ggtagctatt gaggaaacct tctaaaaagc gttgatagtg ctccggtatg ataagggcaa
    41401 agagggggaa ggtggtgcgg aaggtatccc agaaaccatt gttgctaaag aggacaccag
    41461 gcttgacagt accagtagcc agatccatgt ggatggcttg ccctgactca tcaacctcat
    41521 aaaaagtctg tgggaagagg aagagtctgt agagacagtg gtcaaagaag gttcggtcag
    41581 cctctcctgt ctctataatg tcaaaacgat ggaggagatt ttcccaatcc gcttgggcac
    41641 ttgctttaca gctatcaaaa tcttcttgag gtagattgat tagagcttga gaaggagaga
    41701 tgaaagaagt ggctagttgc atctcggttt gactacttgc taagtcaatt cgccagtctc
    41761 cagcttcttg gctgatagca agaatatccg tgttcatttg cagggcagtg aacatcgtta
    41821 gcgaattttt gttagtttca gttttacctt cttgtcgcag ggcaagagtc cgcttatcta
    41881 cttgctctac tgtcagttca tctgctgcgt gaagatagag ggagagggct ttgccttgct
    41941 tttgcttcaa acgaatagaa gcaccatagc aagtcggtgt gagctgggtt tcaatctgat
    42001 agcgcaggga gaaaatcttt agataatgag gttggaaaga ggccttatcc ctatcatagg
    42061 aagattggcg gtgaaagagg ctgtctcccc ccagttgact ggtgacaggt gtcagaagga
    42121 gccaagagta gtccccaatc caaggactgg gctggtgagt taatcgaatc ccctgaaaga
    42181 taggcagatg cggatcaaaa aaccaagctc catcctggtc actggtctgg ggcacaaagt
    42241 aattcatccc aaaaggcacg cctgtgtatg gcagggtatt tccccgagaa aaggcatgcc
    42301 tattggtagt tcccaagcgg gtatcgatgg tttcaagtag tggtttcata gtctttcctt
    42361 tagctgtttt tctacattat atcagaaaaa gagggccttt agaaaaggag tttcaaaaat
    42421 aactattttg tagaaaaatg actatcattt gtgtatgtat tttctgtctc aaaagctata
    42481 tactgaacat gaaacttgtt tgaaagaggg aattgcacga tgatttattc gaaagaaatt
    42541 gttagagaat ggctagatga agtagcagag cgggctaagg accatccaga gtgggtggat
    42601 gttttcgagc gttgctacac cgataccttg gacaatacgg ttgaaatctt agaagatggt
    42661 tcaacttttg tcttgactgg ggatattcct gctatgtggc ttcgggattc gacagcccaa
    42721 ctcagaccct acctgcatgt agctaaaaga gatgccctcc tgcgtcagac cattgcaggt
    42781 ttggtcaaac gtcagatgac cttggtactc aaggatcctt atgccaattc cttcaacata
    42841 gaggaaaact ggaaggggca ccacgagacc gaccacaccg accttaatgg ctggatttgg
    42901 gaacgcaagt atgaggtgga ctcgctttgc tatcctttgc agttggctta tctcctctgg
    42961 aaagaaactg gcgagactag tcagtttgat gagacttttg tcgcagcgac taaggaaatt
    43021 ctccatctat ggacagttga acaagaccac aagaactctc cttatcgttt tgtccgagat
    43081 acggaccgta aggaagacac cttggtaaat gatggctttg gacctgactt tgcagtgaca
    43141 ggtatgactt ggtcagcctt tcgtccgagt gatgactgtt gccagtatag ttacttgatt
    43201 ccgtcaaata tgtttgctgt agtagtcttg ggttatgtgc aagaaatctt cgcagcatta
    43261 aacctagctg atagccagag tgttattgct gatgccaagc gtcttcagga tgaaatccaa
    43321 gaaggaatcg aaaactacgc ttacaccacc aacagcaagg gcgaaaagat ttacgctttt
    43381 gaagtagatg gcctaggaaa tgccagcatt atggatgatc caaacgtacc aagtctacta
    43441 gctgcgccct atctgggcta ctgttcggtc gatgatgaag tgtatcaagc tactcgccgt
    43501 accattctga gctctgaaaa tccatatttc taccaaggag aatacgctag cggtctcgga
    43561 agttctcata ccttctatcg ctatatctgg ccaatcgccc tttctatcca aggcttgaca
    43621 acaagagata aggcagagaa aaacttcttg ctggatcagc tggttgcctg cgatggcggt
    43681 acaggtctta tgcatgaaag cttccacgtg gatgacccaa ctctctactc tcgtgaatgg
    43741 ttctcctggg ctaacatgat gttctgtgag ttggtcttgg attacttgga tattcgctaa
    43801 ggggctcgct ttagctcaac cgattcttat cagaatcaca agtttacatt taaaacgtta
    43861 aaatttaaat ttagaatgag gttttacttc atggaaaatg ttgttgtaca tattatctca
    43921 catagtcact gggaccgtga gtggtacttg ccttttgaaa gtcatcgtat gcagttggtg
    43981 gaattgtttg acaatctctt tgatctcttt gaaaatgacc ctgagttcaa gagtttccac
    44041 ttggatggac aaactattgt ccttgacgac tacttacaaa ttcgccctga aaatcgcgac
    44101 aaggtccaac gctacattga cgagggcaag cttaaaattg gtccctttta catcttgcag
    44161 gatgattatt tgatttcaag tgaagccaat gtccgcaata ccttgattgg tcaacaagaa
    44221 gctgccaaat ggggtaaatc aacccagatt ggctactttc cagatacctt tggaaatatg
    44281 ggacaagcac ctcaaattct tcaaaaatca ggcattcatg tggcggcctt tggtcgtggt
    44341 gtgaagccga ttggatttga caaccaagtc cttgaagatg agcagtttac atcccagttt
    44401 tcagaaatgt actggcaggg tgtggatggt agtcgtgttt taggtattct ctttgccaac
    44461 tggtacagta atgggaatga aatcccagtt gacaaagatg aggccttgac cttctggaaa
    44521 caaaaattgt cagatgtgcg tgcctacgct tcgaccaacc aatggttgat gatgaacggc
    44581 tgtgaccacc agcctgtaca gaaaaatctg agcgaagcca ttcgtgtggc aaatgaactc
    44641 ttcccggatg taatctttgt tcatagttct tttgatgaat atgttcaagc tgtagaaggt
    44701 gcgcttcctg aacacttatc aactgttaca ggcgagttga ccagtcagga aacagatggc
    44761 tggtacacac ttgccaacac ttcttcatcc cgcatttacc taaaacaagc cttccaagaa
    44821 aatagcaacc tcctagagca agtggtagaa cccttgacta ttatcactgg tggacacaac
    44881 cacaaggacc agttgaccta tgcttggaaa acacttttgc agaacgcgcc acatgatagt
    44941 atctgtggct gtagcgtgga cgaagttcac cgcgagatgg aaacgcgttt tgccaaggtc
    45001 aaccaagtag gaaactttgt taaaagtaac ttgctcaacg agtggaaggg taaaattgct
    45061 acggataagg ctcaaagtga ctatctcttt actgtcatta acacaggctt gcatgataag
    45121 gtcgatactg tcagcacagt gattgatgtg gcgacttgtg atttcaagga attgcaccca
    45181 acagaaggct acaaaaagat ggctgctctt atcttgccaa gttaccgtgt ggaggacttg
    45241 gatggtcgtc ctgtagaggc tacaatcgaa gacctcggag ctaattttga gtacgattta
    45301 ccaaaagata agttccgcca agctcgtatt gctcgacaag tgcgcgtgac cattccagtt
    45361 cacctagcgc cgctttcttg gacaaccttc caattgctgg aaggaaaaca agaacaccgt
    45421 gagggtattt accaaaacgg agtgattgat acaccattcg taacggtgag tgtggatgac
    45481 aacatcacag tctatgacaa gacaactcac gaagcctatg aagactttat ccgctttgaa
    45541 gaccgtgggg acatcggaaa cgagtatatc tatttccaac caaaaggaac agagccaatc
    45601 tttgcagagc ttaagggcca cgaggtcttg gaaaacacag cttgctatgc taaaatcttg
    45661 ctcaaacatg aattgaccgt gcctgtcagt gcggatgaaa agctagaaga agagcaacaa
    45721 ggtatcatcg agtttatgaa gcgtgaggct ggacggtcag aagaattgac aaacattcct
    45781 ctggaaactg agttgactgt cttcgttgac aatccacaaa tccgcttcaa gactcgcttt
    45841 actaacactg ccaaggatca ccgtatccgt ctcttggtca agactcataa cacgcgtcca
    45901 agcaatgatt ctgaaagtat ctatgaggtg gtgacacgac caaacaaacc agctgcttca
    45961 tgggaaaacc ctgaaaatcc tcaacaccaa caagcttttg tcagtctgta tgacgatgaa
    46021 aaaggggtga ctgtatccaa taagggattg aatgaatacg aaatccttgg ggataacacc
    46081 attgccgtga ccattttgcg tgcatcaggt gagctaggtg actggggcta cttcccaacg
    46141 ccagaagcac aatgcttgcg ggagtttgaa gtcgagtttg cacttgaatg ccaccaagcc
    46201 caagaacgct tctcagccta tcgtcgtgcc aaagccttgc agacaccgtt taccagcctt
    46261 cagcttgcta gacaggaagg aagcgtggtt gcgactggta gcctcttgag ccattctgtt
    46321 ctcagcatac cgcaagtttg tccaacagcc tttaaagtgg cggaaaatga agaaggctat
    46381 gtcctccgtt actataatat gagtcaagaa aatgtgcgca tatcagaaca tcaacaaacc
    46441 attcttgact tacttgagcg accatatcca gttcattcag gactattggc tccacaagag
    46501 attcgtacag aattcatcaa aaaagaagaa atttaatttc aaaaagtaaa catcaaaaga
    46561 aaggaggggc gaaaaagtaa gaactaactg ctgattcgcc cctttttatg gtaaaaacaa
    46621 tgaccattgc aacgattgat atcggaggga ctgggattaa gtttgccagt ctgactcctg
    46681 atgggaaaat actggataag acaagtattt caacgcctga aaacttggag gatttactag
    46741 cgtggctaga tcaacgcttg tcagaacagg attacagtgg gattgctatg agcgttccag
    46801 gtgcggtcaa tcaagagaca ggtgtgattg atggcttcag tgcggtgccc tacatccatg
    46861 gcttttcttg gtatgaggcg cttagctctt atcagctacc tgtccatctg gaaaatgatg
    46921 ccaactgcgt tggactcagt gaactactag ctcatccaga gcttgaaaat gcagcctgtg
    46981 tcgtgattgg gacagggatt ggcggagcca tgattatcaa tggtagactt catcgaggtc
    47041 gccacggtct gggtggagaa tttggctaca tgacaaccct tgcccctgct gaaaaactta
    47101 ataactggtc gcaactagca tcaactggga atatggtacg atacgtgatt gaaaaatctg
    47161 gtcatactga ttgggacggt cgcaagattt accaagaggc cgcagctggt aatgctcttt
    47221 gtcaagaagc cattgagcgc atgaaccgca atctggcgca aggcttgctc aatatccagt
    47281 atctcatcga tccagatgtc atcagtctgg gtggctctat cagtcaaaat ccagatttta
    47341 tccaaggtgt caagaaggct gttgataact ttgtcgatgc ctacgaagaa tacacggtcg
    47401 caccagttat ccaggcctgc acctatcacg cagatgccaa tctctacggt gcccttgtca
    47461 actggctaca ggaggaaaag caatggtaag atttatagga cttagtccca aacaaacgca
    47521 agctattgag gttttaaaag gtcacatttc tctaccagat gtggaagtgg ctgtcactca
    47581 gtctgaccaa gcctctatct ctatcgaggg tgaggaaggt cactatcaat tgacctaccg
    47641 caaacctcac caactttatc gtgccttgtc cttgttggta acagttctag cagaagctga
    47701 taaagtagag attgaggaac aagcagctta tgaagatttg gcttatatgg ttgactgttc
    47761 tcgaaatgcg gtgctgaatg tcgcttctgc caagcagatg attgagatat tggctctcat
    47821 gggctactca acctttgagc tctacatgga agacacttac cagattgaag ggcagcctta
    47881 ctttggctat ttccgtggag cttattcagc tgaggagttg caggaaatcg aagcctatgc
    47941 ccaacagttt gacatgacct ttgtaccatg catccagacc ttggcccact tgtcggcctt
    48001 tgtcaaatgg ggtgtcaagg aagtgcagga gctccgtgat gtagaggaca ttcttctcat
    48061 tggcgaagaa aaggtttatg acctgattga tggcatgttt gccacgttgt ctaaactgaa
    48121 gactcgcaag gtcaatatcg ggatggacga agcccacttg gttggtttgg gacgctacct
    48181 gattttgaac ggtgttgtgg atcgtagtct cctcatgtgc caacacttgg agcgcgtgct
    48241 ggatattgct gacaaatatg gtttccactg ccagatgtgg agtgatatgt tcttcaaact
    48301 catgtcagcg gatggccagt acgaccgtga tgtggaaatt ccagaggaaa ctcgtgtcta
    48361 cctagaccgt ctcaaagacc gtgtgactct ggtttactgg gattattatc aggatagcga
    48421 ggaaaaatac aaccgtaatt tccgcaatca tcacaagatt agccatgacc ttgcatttgc
    48481 agggggagct tggaagtgga ttggctttac acctcacaac cattttagcc gtctagtggc
    48541 tatcgaggct aataaagcct gccgtgccaa tcagattaaa gaagtcatcg taacgggttg
    48601 gggagacaat ggtagtgaaa ctgcccagtt ctctatccta tcaagcttgc aaatctgggc
    48661 agaactcagc tatcgcaatg acctagatag tttgtctgcg cacttcaaga ccaatactgg
    48721 tctaacggtt gaggatttta tgcagattga ccttgccaac ctcttaccag acctaccagg
    48781 caatctcagc ggtatcaatc ccaaccgcta tgttttttat caggatgttc tttgtccgat
    48841 acttgaccga cacatgacac ctgaacagga caaaccgcac ttcgctcagg ctgctgagac
    48901 gcttgctaac attaaagaaa aagctggaaa ctatgcttat ctctttgaaa ctcaggccca
    48961 gttgaatgct attttaagta gcaaagtaga tgtgggacga cgcattcgtc aggcctacca
    49021 agcggatgat aaagaaagtt tacaacaaat cgccagacaa gaattaccag aacttagaag
    49081 ccaaattgaa gacttccatg ccctctttag tcaccaatgg ctgaaagaaa acaaggtctt
    49141 tggtttggat acagttgaca tccgtatggg cggactcttg caacgcatca aacgagcaga
    49201 aagccgtatc gaggtttatc tggctggcca gcttgaccgc atcgacgagc tggaagttga
    49261 aatcctacca tttactgact tctacgcaga caaggatttc gcagcaacta cagttaacca
    49321 gtggcatacc attgcgacag cttcgacgat ttatacgact taatactctt cgaaaatctc
    49381 ttcaaaccac gtcagcttcc atctacaacc tcaaaacagt gttttgagca gcctgcagct
    49441 agcttcctag tttgctcttt gattttcatt gagtataaaa acaagaacat cttgcttggc
    49501 gcagggtgtt tcgcgtgaaa cagaagaatt atctggtttc aaatgctaca gttagacaaa
    49561 cttatgataa aatagcagaa agtgaatgtt tcctaagagc aattctatcg atgagcaatt
    49621 ggaggtatta tgctacactt aaaattagta aaacaagaaa tagaagctga aaagccagca
    49681 tctgtagaag cttggatcat ttccgtcaaa ttaaaaaagg ttactaccga catatataga
    49741 ttccaaaaac aaaaacgtta gcggaactag cagatgtgat tttatggagt ttcgattttg
    49801 taaatgatca tgctcatgca tttttcatgg ataatgttga gtggagtcat gcagattctt
    49861 actttcttag ctttgttagt gacgatgttg aagaacgtta ccagaacaat atctagatta
    49921 tgatggtttt gactatgaag aatggtaaaa ttgaaatcag tctgtgtagg cttagtattt
    49981 caatagactt cctgcaaaac tagaatccta gttcatgatt gataatacca gcaatcaaat
    50041 tcattcgtaa tccgaagcgt ttacgatgat ttcgatagat tgttgaaaac attttaaacg
    50101 tttttacttt ggcaaagatg ttctcaacct tgcttctctc cttggatagc gcatggttac
    50161 aggctttatc ttcagctgtt agcggcttga gtttgctgga tttacgtgga gtttgtactt
    50221 gaggatatat cttcatgagt ccttaataac cactgtcagc caagatttta ccagcttgtc
    50281 cgatatttct gcgactcatt ttgaacaact tcatatcatg acaatagttc acagcgataa
    50341 ccaaagaaac aattctccct tgacttgtga caatcgcctg agccttcata gcgtggcatt
    50401 tctttttact tccgtcacat caatcattac cgtgtcctca gagctgagag gagttcttga
    50461 aatcgtaaca ccactttgaa caagagttac ttcaacccat tggctccgac ggattaagtt
    50521 gctttcgtga ataccaaaat cagccgcaat ttcttcataa gtgcggtatt ctcgtacata
    50581 ttgaagagtg gccataagaa ggtcttctag gcttaattta ggttttcgtc caccttttgc
    50641 gtgtttaagt tgataagctg tttttaatac agctaacatc tctttaaaag tcgtgcgctg
    50701 aacaccaaca agacgcttaa atcgtgtatc agttaattgt ttacttgctt cataatttcg
    50761 cagggagtct attgactctt tggtaggtgt caatgttttt ttcatctatc ccgagaatta
    50821 ttttcccgcc atttgtattt gcaaatgctg agtaggtttc ccagaaagac tctggaagat
    50881 tgtttttagc ttttttgtat tctaaatcaa ccccttcaaa ttttaagtcc atatttttcc
    50941 tttacatctg ttttttgtgg ttctggtatt tgttaaagtt gagtgataat atagcgaatt
    51001 gaatttcgag agtttttact cagttaattt cttttttaac ccactttaat ttctttttta
    51061 acacgggtta aaaaagaaat taaagtgggt taattttcct tgacttaaaa tttaaaaatg
    51121 atatactgtg tttatggaga gatgacaatt tataaaatgt actactctat tctactagat
    51181 aatgattgaa taaaactttt tataacaacg gctagcaaag ttataatttt atatctatta
    51241 gaaaataaat atgtaaggaa atttaaatga aaaaaactac aatattatca ttaactacag
    51301 ctgcggttat tttagcagca tatgtcccta atgaaccaat cctagcagat actcctagtt
    51361 cggaagtaat caaagagact aaagttggaa gtattattca acaaaataat atcaaatata
    51421 aggttctaac tgtagaaggt aacataggaa ctgttcaagt gggtaatgga gttactcctg
    51481 tagagtttga agctggtcaa gatggaaaac cattcacgat tcctacaaaa atcacagtag
    51541 gtgataaagt atttaccgtt actgaagtag ctagtcaagc ttttagttat tatccagatg
    51601 aaacaggtag aattgtctac tatcctagct ctattactat cccatcaagc ataaaaaaaa
    51661 tacaaaaaaa aggcttccat ggaagtaaag ctaaaactat tatttttgac aaaggcagtc
    51721 agctggagaa aattgaagat agagcttttg atttttctga attagaagag attgaattgc
    51781 ctgcatctct agaatatatt ggaacaagtg cattttcttt tagtcaaaaa ttgaaaaagc
    51841 taaccttttc ctcaagttca aaattagaat taatatcaca tgaggctttt gctaatttat
    51901 caaatttaga gaaactaaca ttaccaaaat cggttaaaac attaggaagt aatctattta
    51961 gactcactac tagcttaaaa catgttgatg ttgaagaagg aaatgaatcg tttgcctcag
    52021 ttgatggtgt tttgttttca aaagataaaa ctcaattaat ttattatcca agtcaaaaaa
    52081 atgacgaaag ttataaaacg cctaaggaga caaaagaact tgcatcatat tcgtttaata
    52141 aaaattctta cttgaaaaaa ctcgaattga atgaaggttt agaaaaaatc ggtacttttg
    52201 catttgcgga tgcgattaaa cttgaagaaa ttagcttacc aaatagttta gaaactattg
    52261 aacgtttagc cttttacggt aatttagaat taaaagaact tatattacca gataatgtta
    52321 aaaattttgg taaacacgtt atgaacggtt taccaaaatt aaaaagttta acaattggta
    52381 ataatatcaa ctcattgccg tccttcttcc taagtggcgt cttagattca ttaaaggaaa
    52441 ttcatattaa gaataaaagt acagagtttt ctgtgaaaaa agatacattt gcaattcctg
    52501 aaactgttaa gttctatgta acatcagaac atataaaaga tgttcttaaa tcaaatttat
    52561 ctactagtaa tgatatcatt gttgaaaaag tagataatat aaaacaagaa actgatgtag
    52621 ctaaacctaa aaagaattct aatcagggag tagttggttg ggttaaagac aaaggtttat
    52681 ggtattactt aaacgaatca ggttcaatgg ctactggttg ggttaaagac aaaggtttat
    52741 ggtattactt aaa
//
LOCUS       DAVHSO010000006        52162 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.006, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000006 DAVHSO010000000
VERSION     DAVHSO010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 52162)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52162)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52162
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.006"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..758)
                     /locus_tag="VVR18_000356"
     CDS             complement(<1..758)
                     /locus_tag="VVR18_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6031952.1"
                     /translation="MTLLDVKHVQKIYKTRFQGNQVEALKDIHFTVEKGDYVAIMGES
                     GSGKSTLLNILAMLDKPSRGQVYLNGTDTATIKNSQASSFRREKLGFVFQDFNLLDTL
                     SVKDNILLPLVLSRRPITEMMKKLVMTAENLGINQLQEKYPYEISGGQKQRVAVARAI
                     ITEPEILLADEPTGALDSKSSAALLDVFNEINERGQTILMVPHSTAAASRAKRVLFIK
                     DGILYNQIYRGEKTERQMFQEISDTLTVMASEVN"
     gene            1186..1377
                     /locus_tag="VVR18_000357"
     CDS             1186..1377
                     /locus_tag="VVR18_000357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031953.1"
                     /translation="MKHKEHILIGFLYLLSPFIGQLLVEHTHFIGTEFTGTAYVICWL
                     SVVISIHHFSKNVLSQQQK"
     gene            complement(1731..2003)
                     /locus_tag="VVR18_000358"
     CDS             complement(1731..2003)
                     /locus_tag="VVR18_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEU6031954.1"
                     /translation="MNSKFYKMRRNRMISGVLAGLSDKWNFDVTLVRFLFAIFTVANF
                     GLGVIIYIILASIMPTKEEIEAEMYGTGPRKRKEAQAIDDNEGWFW"
     gene            complement(2062..2511)
                     /locus_tag="VVR18_000359"
     CDS             complement(2062..2511)
                     /locus_tag="VVR18_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SprT family protein"
                     /protein_id="HEU6031955.1"
                     /translation="MKLTDYVKQVSLEDFGRPFIHHVQWNRRLRSTGGRFFPKDGHLD
                     FNPKVYQELGLDVFRKIVRHELCHYHLYFQGKGYQHKDRDFKELLKAVDGLRFVPSLP
                     NSNSKPIKLYRCQSCQQTYQRKRRIDTRRYRCGLCRGKLLLINQPED"
     gene            complement(2498..4627)
                     /locus_tag="VVR18_000360"
     CDS             complement(2498..4627)
                     /locus_tag="VVR18_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HEU6031956.1"
                     /translation="MDKKYEKISQDLGVMLKQIDTVLSLTAEGATIPFIARYRKDMTG
                     SLDEVAIKAIIDLDKSLTNLNDRKEAVLAKIQEQGKLTKELEEAILVAEKLADVEELY
                     LPYKEKRRTKATIAREAGLFPLARLILQNIVDLEKEAEKFVCEGFATGKEALTGAVDI
                     LVEALSEDVTLRSMTYQEVLRHSKLTSQAKDESLDEKQVFQIYYDFSETVGTMQGYRT
                     LALNRGEKLGVLKIGFEHATDRILAFFATRFKVKNAYIDEVVQQSVKKKVLPAIERRI
                     RTELTEKAEEGAIQLFSDNLRNLLLVAPLKGRVVLGFDPAFRTGAKLAVVDATGKMLT
                     TQVIYPVKPASARQIEEAKKDLADLIGQYGVEIIAIGNGTASRESEAFVAEVLKDFPE
                     VSYVIVNESGASVYSASELARQEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIGV
                     GQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTASPALLSHVAGLNKTISENIVKYRE
                     EEGKITSRSQIKKVPRLGAKAFEQAAGFLRIPESSNILDNTGVHPENYAAVKELFKCL
                     DIKDLNEEAQSKLKSLSVKEMAQELDLGPETLKDIIADLLKPGRDFRDSFDAPVLRQD
                     VLDIKDLVVGQKLEGVVRNVVDFGAFVDIGIHEDGLIHISHISRKFIKHPSQVVAVGD
                     LVSVWVKKIDTEREKVNLSLLAPNETD"
     gene            complement(4729..6045)
                     /locus_tag="VVR18_000361"
     CDS             complement(4729..6045)
                     /locus_tag="VVR18_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000442119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1919 domain-containing protein"
                     /protein_id="HEU6031957.1"
                     /translation="MERQTLKDIEVIIVNQSTEEIASISQQMNLSFNIKIINENSFAE
                     LSDMITGDYITFLSSNDSLFDWTFEKMYHAIKLSDSDVVLGHFADLVDGVFYFYPWGD
                     NWLTENLTNVQVLQKMDDTDHRIRKQYRSLFGKLFNSKLLRKINQFDINNLIWRLYIH
                     SKTATYINFPTYIYKPVIDAKPLKDSYKIILENYENRIKDCAVLENYDIERAKKQYIQ
                     ELANFSAWLKNDGEYLDSDIVYHKLIAAEKGIFPFLELDRLDFTIISNNCVGGLIYKQ
                     LGFQYRTPFVGLFILPDDYYKLTKHFRYYMEQELVFEEELISPSWTHEVYPLGHLGDI
                     DIHFLHYSSIEEARTKWEKRKKRINWNNLYFKFDNKDSASEEILNKMDNLPYSNKLIL
                     VNRPYKNLKSQCVIPGQEHLPELAIMSDPLNTFDIMAWLKKGGNAL"
     gene            6435..7340
                     /locus_tag="VVR18_000362"
     CDS             6435..7340
                     /locus_tag="VVR18_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HEU6031958.1"
                     /translation="MTAFQQLPSSVLQTGAIFLSIIIEALPFVLIGSIVSGLIEVYIT
                     PDKVYHFLPRNRWGRIFFGTFVGILFPSCECGIVPIINRFLEKKVPSYTAVPFLVTAP
                     VINPIVLFATYSAFGNSFHVALLRALGSILVAVILGIFLGFFWQEPIQKENRLACHEH
                     DFSYLSSAKKVFQVFVQAIDEFFDTGRYLVFGCLFASIIQVYVPTRILTSISATPLFA
                     ILLLMLLAFLLSLCSEADAFIGASLLSSFGLAPVLAFLVIGPMLDIKNILMMKNYLKA
                     RFISHFITIVTLVVLAYSLLIGVIL"
     gene            7337..8152
                     /locus_tag="VVR18_000363"
     CDS             7337..8152
                     /locus_tag="VVR18_000363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family protein"
                     /protein_id="HEU6031959.1"
                     /translation="MIRFLVLAGYFELTIYLHLSGKLNQYINMHYSYLAYISMVLSFI
                     LAIVQLYIWMKQVKTHSHLNSRLAKMTSISLLAIPLVIGLTFPTVSLDSQTVSAKGYH
                     FPLSEGTDLAIQTSEGTTSQYLKPDTSSYFSKSAYEKEMRTAADKYLSQDSIQITNEN
                     YMEVMEAIYDYPDEFEGKTIQFTGFVYNDPSHANSQFLFRFGIIHCIADSGVYGLLTK
                     GNTRQYENNTWITAKGKLVNHYHKELKQNLPTLEIDSFTKVDKPENPYVYRAF"
     gene            complement(8282..8890)
                     /locus_tag="VVR18_000364"
     CDS             complement(8282..8890)
                     /locus_tag="VVR18_000364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU6031960.1"
                     /translation="MKKYFISGLGSNAYHSEEESICLIGHSLGGDLARYLASEFEEVK
                     KLILLDGGYLDLDKILPLDTELEETKNYIKSQIVLDLDVLTSKEKSEAKHWSENMEKA
                     VRQSYHWNVEYNRYELAINYENIEAILRLRRKIQAFKREVGDTLFISPRYPNEATWRE
                     EALKELPDYFDTIFLENFGHELYTQAPKEIASLMNEWLAYFL"
     gene            complement(8894..9205)
                     /locus_tag="VVR18_000365"
     CDS             complement(8894..9205)
                     /locus_tag="VVR18_000365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031961.1"
                     /translation="MELKDFTEKEQEMIKKRLTMSNISDKETTEKILALVPQDLIKRI
                     PFFVRKHATTRTIKRISIEYPELYAVAQTSGEIPEKEREELRQIITTIFEQKMNKHSI
                     K"
     gene            9348..9692
                     /locus_tag="VVR18_000366"
                     /pseudo
     CDS             9348..9692
                     /locus_tag="VVR18_000366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(9661..9825)
                     /locus_tag="VVR18_000367"
     CDS             complement(9661..9825)
                     /locus_tag="VVR18_000367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001836122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031962.1"
                     /translation="MTVILGFLFLFLMSWWVISIVNSQKPLKNETFIGYVQRYDIDGN
                     GYQSLPCPQN"
     gene            complement(9838..10710)
                     /locus_tag="VVR18_000368"
     CDS             complement(9838..10710)
                     /locus_tag="VVR18_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HEU6031963.1"
                     /translation="MKKSRKLATLGICSALFLGLAACQQQHATSEGTNQRQSSSAKVP
                     WKASYTNLNNQVSTEEVKSLLSAHLDPNSVDAFFNLVNDYNTIVGSTGLSGDFTSFTH
                     TEYDVEKISHLWNQKKGDFVGTNCRINSYCLLKNSVTIPKLEKNDQLLFLDNDAIDKG
                     KVFDSQDKEEFDILFSRVPTEATTDVKVHAEKMETFFSQFQFNEKARMLSVVLHDNLD
                     GEYLFVGHVGVLVPADDGFLFVEKLTFEEPYQAIKFASKEDCYKYLGTKYADYTGEGL
                     AKPFIMDNDKWVKL"
     gene            complement(12394..13899)
                     /gene="pyk"
                     /locus_tag="VVR18_000369"
     CDS             complement(12394..13899)
                     /gene="pyk"
                     /locus_tag="VVR18_000369"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HEU6031964.1"
                     /translation="MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAK
                     LIEAGANTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFEGE
                     AKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVLVDDGKLGLRV
                     VAKDDETREFEVEVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIA
                     ISFVRTAKDVNEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG
                     IEVPFEMVPVYQKMIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGT
                     DATMLSGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVK
                     DATSSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
                     APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTVR"
     gene            complement(13958..14965)
                     /gene="pfkA"
                     /locus_tag="VVR18_000370"
     CDS             complement(13958..14965)
                     /gene="pfkA"
                     /locus_tag="VVR18_000370"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HEU6031965.1"
                     /translation="MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGM
                     VAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGG
                     DGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSH
                     RRTFVIEVMGRNAGDIALWAGIATGADEIIIPEADFKMEDIVASIKAGYECGKKHNII
                     VLAEGVMSAAEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVKLL
                     KEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSL
                     S"
     gene            complement(15047..18148)
                     /locus_tag="VVR18_000371"
     CDS             complement(15047..18148)
                     /locus_tag="VVR18_000371"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000561528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HEU6031966.1"
                     /translation="MIAQLDTKTVYSFMESVISIEKYVRAAKEYGYTHLAMMDIDNLY
                     GAFDFLEITKKYGIHPLLGLEMTVFVDDQEVNLRFLALSSVGYQQLMKLSTAKMQGEK
                     TWSVLSQYLEDIAVIVPYFDRVESLELGCDYYIGVYPETLASEFHHPILPLYRVNAFE
                     SRDREVLQVLTAIKENLPLREVPLRSRQDVFISASSLEKLFQERFPQALDNLEKLISG
                     ISYDLDTSLKLPRFNPARPAVEELRERAELGLVQKGLTSKEYQDRLDQELSVIHDMGF
                     DDYFLVVWDLLRFGRSNGYYMGMGRGSAVGSLVSYALDITGIDPVEKNLIFERFLNRE
                     RYTMPDIDIDIPDIYRPDFIRYVGNKYGSKHAAQIVTFSTFGAKQALRDVLKRFGVPE
                     YELSAITKKISFRDNLKSAYEGNLQFRQQINSKLEYQKAFEIACKIEGYPRQTSVHAA
                     GVVISDQDLTNYIPLKYGDEIPLTQYDAHGVEASGLLKMDFLGLRNLTFVQKMQELLA
                     EIEGIHLKIEEIDLEDKETLALFASGNTKGIFQFEQPGAIRLLKRVQPVCFEDVVATT
                     SLNRPGASDYINNFVARKHGQEEVTVLDPVLEDILAPTYGIMLYQEQVMQVAQRLAGF
                     SLGKADILRRAMGKKDASAMHEMRASFIQGSLEAGHTVEKAEQVFDVMEKFAGYGFNR
                     SHAYAYSALAFQLAYFKTHYPAIFYQIMLNSANSDYVTDALEAGFEVAPLSINTIPYH
                     DKIANKSIYIGLKSIKGLSKDLALWIIEHRPYSNIEDFIAKLPENYLKLPLLEPLVKV
                     GLFDLFEKNRQKVFNNLANLFEFVKELGSLFGDAIYSWQESEDWTEQEKFYMEQELLG
                     IGVSKHPLQAIASKAIYPITPIGNLSENSYAIILVEVRKIKVIRTKKGENMAFLQADD
                     SKKKLDVTLFSDLYRQVGQEIKEGAFYYVKGKIQSRDGRLQMIAQEIREAVAERFWIQ
                     LKNHDSEQEMSRILDQYKGPIPVIIRYEEEQKTIVSPHHFVAKSDELEAKLNGIVMKT
                     IYR"
     gene            18495..20768
                     /locus_tag="VVR18_000372"
     CDS             18495..20768
                     /locus_tag="VVR18_000372"
                     /EC_number="3.4.14.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Xaa-Pro dipeptidyl-peptidase"
                     /protein_id="HEU6031967.1"
                     /translation="MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRF
                     FFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDV
                     FRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLAT
                     FSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKA
                     SDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDY
                     FLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVK
                     ADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGG
                     YPGEDFDSLAELTYSRNLLAGDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYL
                     LNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSID
                     FRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQ
                     AIQNQYPDKDFERYGKTYQTFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSS
                     TNKGLLSAQLLEFGQKKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKG
                     YLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNT
                     DYHLTVDLAQSMLTLPC"
     gene            20785..21255
                     /locus_tag="VVR18_000373"
     CDS             20785..21255
                     /locus_tag="VVR18_000373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001043003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEU6031968.1"
                     /translation="MNKSEHRHQLIRALITKNKIHTQAELQALLAKNDIQVTQATLSR
                     DIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGL
                     AQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE"
     gene            complement(21452..21553)
                     /locus_tag="VVR18_000374"
                     /pseudo
     CDS             complement(21452..21553)
                     /locus_tag="VVR18_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(21797..25129)
                     /locus_tag="VVR18_000375"
     CDS             complement(21797..25129)
                     /locus_tag="VVR18_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000526318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEU6031969.1"
                     /translation="MGNFSFLLKNDEYESFSKPCIEAENMIATSTVATAFMARRALEQ
                     AVHWIYSHDSYLEAPYRATLSSLVWDDDFRDIVDSELHKQIVLLIRWGNHAAHGGEIK
                     EREAILALHHLYQFVNFIDYCYSNEFVERYFDEKCLPLSANIKYRETPQSMIKLQDSL
                     PELPDFHEQMAAQSVEVQETYTEKRETAAQRQDVPFHIDQLSEAETRKLFIDIDLRLA
                     GWIFEENCRVEIAVDGLKHGSGIGYCDYVLYGKNGKILAIVEAKKASVNPEVGEVQVK
                     EYAEALEKHIGYQPICFITNGLKHYILDGPNRRQIAGFYSQEELQLVMDRRHLQKPLE
                     DISSKIRDDISGRHYQKHAIASVCEAFSNHRRQALLVMATGAGKTRTAVSLVDILSRH
                     NWVKNVLFLADRTSLVKQAYDSFRKLLPDLSVCNFLEDKEGAQSSRMVFSTYPTMIGA
                     ISGQEEVNQRPFTVGHFDLIIIDESHRSIYQKYKSIFDYFDARIVGLTATPRQDLDKN
                     TYGFFNLENGVPTYAYDLEEAVKDGYLVTYHSIETKLKLPTDGLHYDDLSEEEKEHFD
                     SKFEDDSCEKDIDGSVFNSFVFNKSTVEIVLNELMTRGIQTASGDEIGKTIIFAKNHD
                     HAEYIRGIFNNRYPEKGSDYAQVIDYSIKHYQTLIDDFKIKEKYPQIAISVDMLDTGI
                     DVPEVVNLVFFKKVRSKTKFWQMIGRGTRLCKDLFGPEQDKENFLVFDYFRADPRDGE
                     GRHIVSLTQRLFNIKVDLIRELQGLQYQEDQFARAYRQQLVSELQGRIESLNELDFRV
                     RMVLDTVYSYRKLESWQNLTTVTSETIQKNLSPLLFDEDKEDEMARRFDLWLLHIQLG
                     QLTAKSSTVHISQVMKTARALSAIGNIPQVFEQAEIIRKVQEPEFWKEVNLSDLEKIR
                     LAIRDLLQFLDKTDRKPYYVNFEDRILSTVHETTAFLQVNDLRSYNEKVEHYLKTHLD
                     EESISKLYHNKKLTSDDMLALEKLLWEKLGSKADYQSHYENKAIPRLVREIIGLDRES
                     ANRIFSKFLSDENLNARQISFVKLIVDYIVENGFLETKVLTQEPFKSYGSVQLLFQHQ
                     LPVLRNIVQIIELINNRAGEAA"
     gene            complement(25159..26268)
                     /locus_tag="VVR18_000376"
     CDS             complement(25159..26268)
                     /locus_tag="VVR18_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU6031970.1"
                     /translation="MKKVKLGEVLSLKKGKKATVLAEQTTLSQRYIQIDDLRNNNNLK
                     FTESLNMTEALPDDILIAWDGANAGTVGYGLSGAVGSTITVLKKNERYKEKIISDYLG
                     VFLESKSQYLRDHSTGATIPHLNKNILLDLQLELLGIEEQENIICILNTIKRLITKRK
                     LQLDELNLLVKSRFNEMFGENKIFESIDNLFDIIDGDRGKNYPKSDELFSEEYCLFLN
                     TKNVTKNGFSFDTKQFITKTKDKLLRKGKLERYDIVLTTRGTVGNVAYYDELIKYKHL
                     RINSGMVILRPKTPNLNQKFIIHVLRNNNYSRVISGSAQPQLPITKLKKILLPLPPLA
                     LQNEFADFVVQVDKSQFACEIAIKVWRNSLKFSII"
     gene            complement(26281..27774)
                     /locus_tag="VVR18_000377"
     CDS             complement(26281..27774)
                     /locus_tag="VVR18_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEU6031971.1"
                     /translation="MITGELKNKIDQLWEILWTEGNANPLTNIEQLTYLLFMKDLDSV
                     ELGRESDAEFLGIPYEGVFPKDKPEYRWSTFKNIGDAQEVYRLMTQEIFPFIKNLKGD
                     TDDTAFSRYMREAIFQINKPATLQKAISILDVFPTRGLDVDFDNDKQSITDIGDIYEY
                     LLSKLSTAGKNGQFRTPRHIIDMMVELMQPTIKDIISDPAMGSAGFLVSASRYLKRKK
                     DEWETNTDNINHFHNQMFHGNDTDTTMLRLGAMNMMLHGVENPQISYLDSLSQDNEEA
                     DKYTLVLANPPFKGSLDYNSTSNDLLATVKTKKTELLFLSLFLRTLKPGGRAAVIVPD
                     GVLFGSSKAHKGIRQEIVENHKLDAVISMPSGVFKPYAGVSTAILIFTKTGNGGTDKI
                     WFYDMKADGLSLDDKRQPISDNDIPDIIERFHHLEKEAERQRTDQSFFVPVAEIKEND
                     YDLSINKYKEIEYEKVEYEPTEVILKKINDLEKEIQAGLAELEKLLK"
     gene            complement(28282..29448)
                     /locus_tag="VVR18_000378"
     CDS             complement(28282..29448)
                     /locus_tag="VVR18_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEU6031972.1"
                     /translation="MNYLVISPYYPQNFQQFTIELANKGITVLGIGQESYEQLDEPLR
                     NSLTEYFRVDNLENIDEVKRAVAFLFYKHGPIDRIESHNEYWLELDATLREQFNVFGA
                     KPEDLKKTKYKSEMKKLFKKAGVPVVPGAVIKTEADVDQAVKEIGLPMIAKPDNGVGA
                     AATFKLETEDDINHFKQEWDHSTLYFFEKFVTSSEICTFDGLVDKDGKIVFSTTFDYA
                     YTPLDLMIYKMDNSYYVLKDMDPKLRKYGEAIVKEFGMKERFFHIEFFREGDDYITIE
                     YNNRPAGGFTIDVYNFAHYLDLYRGYAAIVAGEEFPASDFETQYCLATSRRANAHYVY
                     SEEDLLAKYSQQFKVKKVMPAAFAELQGDYLYMLTTPSRQEMEQMIADFGQRQE"
     gene            complement(29461..30200)
                     /locus_tag="VVR18_000379"
                     /pseudo
     CDS             complement(29461..30200)
                     /locus_tag="VVR18_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546805.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
     gene            complement(30222..31046)
                     /locus_tag="VVR18_000380"
     CDS             complement(30222..31046)
                     /locus_tag="VVR18_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU6031973.1"
                     /translation="MNQSYFYLKMKEHKLKVPYTGKERRVRILLPKDYEKDTDRSYPV
                     VYFHDGQNVFYSKESFIGYSWKIIPAIKRNPDISRMIVVAIDNDGMGRMNEYAAWKFQ
                     ESPIPEQQFGGKGVEYAEFVMEVVKPFIDETYRTKADCQHTAMIGSSLGGNITQFIGL
                     EYQDQIGCLGVFSSANWLHQEAFNRYIECQKLSPDQHIFIYVGTEEADDTDKTLMDGN
                     IKQAYIDSSLCYYHDLIAGGVHLDNLVLKVQSGAIHSEIPWSENLPDCLRFFAEKW"
     gene            complement(31183..32397)
                     /gene="thiI"
                     /locus_tag="VVR18_000381"
     CDS             complement(31183..32397)
                     /gene="thiI"
                     /locus_tag="VVR18_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HEU6031974.1"
                     /translation="MQYSEIMIRYGELSTKGKNRMRFINKLRNNISDVLSIYPQVKVT
                     ADRDRAHAYLNGADYTAVAESLKQVFGIQNFSPVYKVEKSVEVLKSAVQEIMRDIYKE
                     GMTFKISSKRSDHNFELDSRELNQTLGGAVFEAIPNVQVQMKSPDINLQVEIREEAAY
                     LSYETIRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPG
                     ALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRITDRIR
                     EVRNGLVIINGESLGQVASQTLESMKAINAVTNTPIIRPVVTMDKLEIIDIAQEIDTF
                     DISIQPFEDCCTIFAPDRPKTNPKIKNAEQYEARMDVEGLVERAVAGIMITEITPQAE
                     KDEVDDLIDNLL"
     gene            complement(32406..33548)
                     /locus_tag="VVR18_000382"
     CDS             complement(32406..33548)
                     /locus_tag="VVR18_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEU6031975.1"
                     /translation="MIYFDNSATTRPYPEALETYMQVASKILGNPSSLHRLGDQATRI
                     LDASRQQIADLIGKKSDEIFFTSGGTEGDNWIIKGVAFEKAQFGKHIIVSAIEHPAVK
                     ESALWLKAQGFEVDFAPVDKKGFVDVEALEDLIRPDTTLVSIMAVNNEIGSVQPIEAI
                     SKLLADKPTISFHVDAVQALAKIPTEKYLTERVDFATFSGHKFHGIRGVGFIYIKSGK
                     KITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIRQALL
                     DYPDIFVFSDEEDFAPHILTFEIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGT
                     LIAMGVDKDKAQSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR"
     gene            33686..34114
                     /locus_tag="VVR18_000383"
     CDS             33686..34114
                     /locus_tag="VVR18_000383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031976.1"
                     /translation="MSNYRRTSKPKTEHIKKGFTVFQKTITTIGSILGLITAGITIMN
                     ALDNNNKNTKKEPTTSQTTTFVKEIQKESPQENTTPNKENNTSQEKTQQEETPKSSVK
                     EEKKEDQKTATQDSTTPATSKPATENEKQPTTPTSENNTQ"
     gene            complement(34265..36490)
                     /locus_tag="VVR18_000384"
     CDS             complement(34265..36490)
                     /locus_tag="VVR18_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEU6031977.1"
                     /translation="MLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGL
                     LIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLT
                     GFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWSVYDIAEFFS
                     RGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPPVDMETGEIL
                     TEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAKEALEYKLPS
                     LQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVG
                     VRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDITTVSFRELWEQSQTK
                     AENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQV
                     KFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMESRYELFAKVGVRNI
                     AGFNAKVEEFNSQSEYKQIPLPLIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGI
                     HMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRGDMLFKP
                     IDENHPVRLQGSFISDDDVERIVNFIKAQADADYDESFDPGEVSENEGEFSDGDAGGD
                     PLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEMAGVIGPAEGTKPRKVLQ
                     Q"
     gene            complement(36654..38606)
                     /locus_tag="VVR18_000385"
     CDS             complement(36654..38606)
                     /locus_tag="VVR18_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6031978.1"
                     /translation="MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETF
                     KEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFM
                     IAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
                     ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDI
                     RKAKAIIIAADKAVEMDRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAK
                     AATASNEKQSLGGAFYKHLMSGVSQMLPFVIGGGIMIALAFLIDGALSVPNENLGNLG
                     SYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIP
                     YAAGGEATSTLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLG
                     TILTGFVMLAVNIPMAAINTAMNDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAY
                     VFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSGLTNIIM
                     GLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNA
                     LLYLVSVLVGAIVSGVVYGYLRKPQA"
     gene            complement(38603..39514)
                     /gene="pfkB"
                     /locus_tag="VVR18_000386"
     CDS             complement(38603..39514)
                     /gene="pfkB"
                     /locus_tag="VVR18_000386"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015605104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HEU6031979.1"
                     /translation="MIYTVTLNPSIDYIVRLDQVKVGSVNRMDSDDKFAGGKGINVSR
                     VLKRLNIPNTATGFIGGFTGKFITDTLAEEEIETRFVQVAEDTRINVKIKADQETEIN
                     GTGPTVESVQLEELKAILSSLTAEDTVVFAGSSAKNLGNVIYKDLISLTRQTGAQVVC
                     DFEGQTLIDSLDYQPLLVKPNNHELGAIFGVKLESLDEIEKYARELLAKGAQNVIISM
                     AGDGALLVTSEGAYFAKPIKGTVKNSVGAGDSMVAGFTGEFVKSKDVVEAFKWGVACG
                     TATTFSDDLATAEFIKETYGKVEVEKR"
     gene            complement(39511..40251)
                     /locus_tag="VVR18_000387"
     CDS             complement(39511..40251)
                     /locus_tag="VVR18_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU6031980.1"
                     /translation="MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELE
                     AENKLRRVHGGAELPYSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGT
                     TTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
                     QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVA
                     PLKRAIVITSQGHELLQVIKEKTEVIEV"
     gene            40413..40500
                     /locus_tag="VVR18_000388"
     tRNA            40413..40500
                     /locus_tag="VVR18_000388"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:40447..40449,aa:Ser,seq:gga)
     gene            complement(40683..41030)
                     /gene="ssrA"
                     /locus_tag="VVR18_000389"
     tmRNA           complement(40683..41030)
                     /gene="ssrA"
                     /locus_tag="VVR18_000389"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(41564..42673)
                     /locus_tag="VVR18_000390"
     CDS             complement(41564..42673)
                     /locus_tag="VVR18_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEU6031981.1"
                     /translation="MFRRNKLFFWTTEILLLTIIFYLWRQMGSLINPFVSVLNTIMIP
                     FLLGGFLYYLTNPIVTFLNKVCKLNRLLGILITLCTLVWGMVIGVVYLLPILINQLSS
                     LIISSQTIYSRVQDLIIDLSNYPALQNLDVEATIQQLNLSYVDILQNILNSVSNSVGS
                     VLSALISTVLILIMTPVFLVYFLLDGHKFLPMLERTILKRDRLHIAGLLKNLNATIAR
                     YISGVSIDAIIIGCLAYIGYSIIGLKYALVFAIFSGVANLIPYVGPSIGLIPMIIANI
                     FTDPHRLLIAVIYMLVVQQVDGNILYPRIVGSVMKVHPITILVLLLLSSNIYGVVGMI
                     VAVPTYSILKEISKFLSRLYENHKIMKERERELAK"
     gene            42776..44017
                     /locus_tag="VVR18_000391"
     CDS             42776..44017
                     /locus_tag="VVR18_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HEU6031982.1"
                     /translation="MKKTFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILY
                     EKDATQPVEIASITKLITVYLVYEALENGSITLSTPVDISDYPYQLTTNSEASNIPME
                     ARNYTVEELLEATLVSSANSAAIALAEKIAGSEKDFVDMMRAKLLEWGIQDATVVNTT
                     GLNNETLGDNIYPGSKKDEENKLSAYDVAIVARNLIKKYPQVLEITKKPSSTFAGMTI
                     TSTNYMLEGMPAYRGGFDGLKTGTTDKAGESFVGTTVEKGMRVITVVLNADHQDNNPY
                     ARFTATSSLMDYISSTFTLRKIVQQGDAYQDSKAPVQDGKEDTVTAVAPEDIYLIERV
                     GNQSSQSVQFTPDSKAIPAPLEAGTVVGHLTYEDKDLIGQGYITTERPSFEMVADKKI
                     EKAFFLKVWWNQFVRFVNEKL"
     gene            complement(44216..45628)
                     /gene="sufB"
                     /locus_tag="VVR18_000392"
     CDS             complement(44216..45628)
                     /gene="sufB"
                     /locus_tag="VVR18_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufB"
                     /protein_id="HEU6031983.1"
                     /translation="MAEERVEPKPIDLGEYKFGFHDDVEPVLSTGKGLNEGVIRELSA
                     AKGEPEWMLEFRLKSYETFKKMPMQTWGADLSEIDFDDLIYYQKPSDKPARSWDDVPE
                     KIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEFQKLGIIFTDTDSALKEYPD
                     LFKQYFAKLVPPTDNKLAALNSAVWSGGTFIYVPKGVKVDIPLQTYFRINNENIGQFE
                     RTLIIVDEGASVHYVEGCTAPTYSSNSLHAAIVEIFALDGAYMRYTTIQNWSDNVYNL
                     VTKRAKAQKDATVEWIDGNLGAKTTMKYPSVYLDGEGARGTMLSIAFANAGQHQDTGA
                     KMIHNAPHTSSSIVSKSIAKGGGKVDYRGQVTFNKNSKKSVSHIECDTIIMDDLSASD
                     TIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELP
                     MEYAVELNRLISYEMEGSVG"
     gene            complement(45682..46122)
                     /locus_tag="VVR18_000393"
     CDS             complement(45682..46122)
                     /locus_tag="VVR18_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SUF system NifU family Fe-S cluster assembly
                     protein"
                     /protein_id="HEU6031984.1"
                     /translation="MALSKLDSLYMAVVADHSKNPHHQGKLEDAEQISLNNPTCGDVI
                     NLSVKFDAEDRLEDIAFLNSGCTISTASASMMTDAVLGKTKQEILELATIFSEMVQGQ
                     KDERQDQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQ"
     gene            complement(46109..47335)
                     /locus_tag="VVR18_000394"
     CDS             complement(46109..47335)
                     /locus_tag="VVR18_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEU6031985.1"
                     /translation="MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINS
                     YYEQDNANVHRGVHTLAERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVAR
                     FAEEILAEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
                     KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFA
                     FSGHKMAGPTGIGVLYGKEKYLEQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPN
                     MAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLTIYGSQNLAQRSGVI
                     AFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDK
                     LVDALQKTKEFFNGTF"
     gene            complement(47346..48608)
                     /gene="sufD"
                     /locus_tag="VVR18_000395"
     CDS             complement(47346..48608)
                     /gene="sufD"
                     /locus_tag="VVR18_000395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufD"
                     /protein_id="HEU6031986.1"
                     /translation="MTRENIKLFSEMHAEPSWLADLRQKAFDKIETLELPVIERVKFH
                     RWNLGDGTITENEPSANVPDFTALDHHLKLVQVGTQTVFEQTPVELAEQGVVFTDFHS
                     ALEEIPELIEEFFMSSVKYDDDKLAAYHTAYFNSGAVLYIPDNVEITEPIEGIFYQDS
                     DSNVPFNKHIMIIAGKNSKISYLERLESRGEGSDKVTANITVEVIARSGAQVKFAAID
                     RLGENVTAYISRRGKLGNDASIDWAIGVMNEGNVVADFDSDLIGNGSHADLKVVALSS
                     GRQVQGIDTRVTNYGCNSIGNILQHGVILEKATLTFNGIGHIIKGAKGADAQQESRVL
                     MLSDQARSDANPILLIDENDVTAGHAASIGQVDPEDMYYLMSRGLDKATAERLVVRGF
                     LGSVIVEIPVKEVRDEMIATIEEKLSKR"
     gene            complement(48636..49406)
                     /gene="sufC"
                     /locus_tag="VVR18_000396"
     CDS             complement(48636..49406)
                     /gene="sufC"
                     /locus_tag="VVR18_000396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000114488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="HEU6031987.1"
                     /translation="MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKST
                     LSAAIMGNPNYEVTKGEVLFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLR
                     AAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLL
                     MLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHV
                     MMEGRVVLSGGPELAARLEREGYAKLAEELGYDYKEEL"
     gene            complement(49556..49750)
                     /locus_tag="VVR18_000397"
     CDS             complement(49556..49750)
                     /locus_tag="VVR18_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3272 domain-containing protein"
                     /protein_id="HEU6031988.1"
                     /translation="MNKQQFIIMALFTAAETYFFNEAWMTGRYIMAAFWAILLFRNFR
                     VSYVMGKIVDVIDQHFNRKD"
     gene            complement(49778..51433)
                     /gene="dnaX"
                     /locus_tag="VVR18_000398"
     CDS             complement(49778..51433)
                     /gene="dnaX"
                     /locus_tag="VVR18_000398"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HEU6031989.1"
                     /translation="MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSG
                     PRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDE
                     IREIRDKSTYAPSLARYKVYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
                     IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALS
                     ILDQALSLTQGNELTTAISEEITGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGK
                     SMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLFEMIRLATVSLADIK
                     SSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNVGAVPKQVA
                     PAPSRPATGKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKA
                     LLVGSQPVAANEHHAILAFESNFNAGQTMKRDNLNTMFGNILSQAAGFSPEILAISME
                     EWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED"
     gene            complement(51433..51930)
                     /locus_tag="VVR18_000399"
     CDS             complement(51433..51930)
                     /locus_tag="VVR18_000399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GAF domain-containing protein"
                     /protein_id="HEU6031990.1"
                     /translation="MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPN
                     TVFAGFYLFDGKELVLGPFQGGVSCIRIALGKGVCGEAAHFQETVIVGDVTTYLNYIS
                     CDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDAMDRDYLEQFVAILLEKTTWDFTM
                     FEEKS"
BASE COUNT        15713 a        11204 c         9275 g        15970 t
ORIGIN      
        1 taattcacct cgcttgccat gacagtcaag gtatcagaga tttcttggaa catctgacgc
       61 tctgtcttct ctccacggta gatttggttg taaagaatgc cgtctttgat aaagagaaca
      121 cgcttggccc tgctagcagc tgctgttgag tggggtacca tgaggatggt ttgcccacgc
      181 tcattgattt cattaaagac atcaagtaag gctgcagatg acttggaatc aagggctcct
      241 gttggctcgt ccgccaggag aatttcaggt tctgtgatga tggcgcgggc tactgctaca
      301 cgctgtttct gaccaccaga aatctcgtaa gggtacttct cttgcaattg gttgataccc
      361 agattttcag ctgtcatcac caatttcttc atcatctccg ttataggtct tcttgacaag
      421 acaagcggaa gcaagatatt gtccttaaca gacagagtat ctagcaagtt aaagtcttgg
      481 aagacaaatc ctagcttttc acgccggaaa ctagaagcct gtgaattttt aatagttgct
      541 gtatcagttc cgtttaggta aacctgccca cgacttggtt tatccagcat agctaggata
      601 ttgagcagag tggatttacc agaaccagac tcacccatga tagcaacgta gtcacccttt
      661 tctacggtga agtgaatatc cttgagggcc tctacttggt tgccctgaaa acgagtttta
      721 taaatttttt gaacgtgttt tacatctaaa agtgtcatga gaatctcctt tcttaatatc
      781 ccatcaaatg aaatgtagct tgcatcatag tgcatcccag ctgaatgcgc tcaatttctt
      841 tgtgacttgg ttttctagtt tttttatgta agatttgttt catgatgtta ctcctttgtt
      901 ctttatgagt ctagtttaca tcaaaaaaag accgcttgcc ataacctaac cttacaaaag
      961 agactttaat cttacatttt tgtaagattg ggtgaaatat aagcaaaatt acttagaaaa
     1021 tgatttgatt tcctattttt aaagttgtaa aatataagta tgaaaaggct tactttaaaa
     1081 aggaggaagc gggaactaac attttagtaa ggttacctag ataacatacc attcaattta
     1141 acacttgcaa gtcgttcaac ctataaggaa agaaggtgcg ttttaatgaa acacaaagaa
     1201 catatactca tcggatttct ctatctgctc tctccattca tcggtcagct cttagttgaa
     1261 cacacacact ttatcggtac agaatttacc ggcactgctt atgttatttg ctggttatca
     1321 gttgttatca gcatccacca tttttccaaa aatgtattgt ctcagcagca aaaatagatt
     1381 aaaaaactgc atttaaatta ctgcttttat agtaaaatga aataagaata ggacaaatcg
     1441 atcaggacag tcaaatcgat ttctaacaat attttagaag tagaggtgta ctattctagt
     1501 tccaatccac tatagtttgt ggatgaagct gacgaaatat tattaatact attcaaaaat
     1561 caaagtgcaa actatgtcaa cttcacattg ccgactaaat tacagcctgc ggctggcttc
     1621 ctagtttgca ctttgatttt tattgagtat aaaagtaaaa aagctttaaa tcaagcagtt
     1681 tagactattg atttaaagct ttttgcgtat tccaaatctt ttgtaaaacc tcaccaaaac
     1741 cagccttcat tatcgtcaat ggcttgagct tctttgcgtt tacgtgggcc tgttccgtac
     1801 atttctgctt cgatttcttc cttggttggc atgatagaag ctaggatgat atagataatc
     1861 accccaagtc caaagtttgc gactgtaaaa atggcaaaca gaaaacgtac aagggtaaca
     1921 tcaaagttcc acttgtctga cagacctgct aaaactcctg aaatcatgcg atttcgtctc
     1981 attttataaa acttactgtt catgatattt cctctttctg ctaggttaga catagtatat
     2041 cacgggtagg ctcggctttc atcagtcctc aggctgattt attagtagca atttacctcg
     2101 acaaagtcca cagcgatagc gtctggtatc aatcctacgc ttacgctgat aagtttgctg
     2161 gcaggattgg caacgataga gcttgattgg cttggagtta ctattgggca aggatggtac
     2221 aaaccgtaat ccatccactg ctttcaacag ttccttaaaa tcccgatcct tatgttgata
     2281 gcctttccct tgaaaataga ggtgataatg acagagttca tgtcggacaa ttttcctaaa
     2341 aacgtccaac cccagttcct gataaacctt gggattaaaa tccaaatgcc catcttttgg
     2401 gaaaaatcgc ccacctgtcg aacgtagacg cctattccac tggacatgat ggataaaagg
     2461 tctgccgaag tcttctagtg aaacctgctt gacgtaatca gtcagtttca tttggagcta
     2521 ggagagacag attaactttt tcacgttcag tatcaatttt cttaacccaa acgctcacca
     2581 aatctccaac tgccaccact tgactagggt gtttgataaa cttgcgactt atatgggaaa
     2641 tatggatgag accgtcctca tgaattccga tatcaacaaa agcaccgaaa tcaacaacgt
     2701 tacgcaccac tccttctagc ttttgtccaa ccactaagtc cttgatatct aggacatctt
     2761 gacggagaac tggagcatca aaggaatcac ggaaatctcg acctggtttg agaagatctg
     2821 caatgatatc tttaagagtt tctggaccaa ggtctaactc ttgcgccatt tccttgactg
     2881 aaagcgactt gagtttgctt tgggcctctt cattcagatc cttaatatcc aagcatttga
     2941 agagttcctt aacggcagcg taattttctg ggtgaactcc tgtattatca aggatattgc
     3001 tactttcagg gatacggagg aaaccagcag cctgttcaaa agccttggcc cccaaacgag
     3061 gaactttctt gatttgggag cgtgaagtga tttttccctc ttcctcacgg tatttgacga
     3121 tattttcaga aatggtttta ttgagtccag ctacgtgtga aagaagagct gggctagctg
     3181 tattgacatt gacaccaact tggttaacca ctgtatcgac aacaaagtcc agactctcag
     3241 atagtttctt ctgactgaca tcgtgttggt attgaccgac accaattgac ttaggatcga
     3301 ttttgaccaa ttccgcaaga ggatcttgca aacgacgggc gatagaaatg gcagagcgtt
     3361 tttcaacggt caagtctgga aactcctgac gagcaagttc gctggcagaa tagacagaag
     3421 caccactttc attaacgata acatagctga cttcagggaa atctttcaga acttccgcta
     3481 caaaagcttc actttcacga ctggccgttc catttccaat ggcaataatc tctacaccgt
     3541 attgaccaat taaatctgct aaatctttct tggcttcttc gatttgacga gctgatgctg
     3601 gtttaacagg ataaataacc tgagttgtca gcatttttcc tgttgcatcc acgacagcta
     3661 gcttggcacc tgtacgaaag gctgggtcaa acccaagaac cacgcgccct ttcagtggag
     3721 caaccaagag gagattgcgc agattgtcag aaaaaagttg gatagctccc tcttcagctt
     3781 tctcagttaa ttctgtccga atacgacgct caatagcagg caagaccttt ttcttaacgg
     3841 attgctgaac aacttcatca atataagcat ttttcacctt gaaacgagta gcaaagaagg
     3901 caagaatacg gtccgtcgca tgttcaaaac cgatcttcaa gacaccaagt ttctccccac
     3961 gattgagagc caaggtacga tagccttgca tagttccaac tgtctctgaa aaatcataat
     4021 aaatctgaaa aacctgcttt tcatcaagac tttcatcctt ggcttgagaa gtaagtttag
     4081 agtgtctcag cacttcctga taagtcatag aacgcaaggt cacatcttcc gataaggctt
     4141 cgaccaaaat atcaactgca ccggtcaagg cttccttgcc agtcgcaaat ccttcacaga
     4201 cgaacttttc agcttctttc tctaagtcaa ctatattctg caaaatcaaa cgagcaagag
     4261 gaaagagtcc agcttcacgg gcaatggttg ccttggtacg acgcttttcc ttataaggaa
     4321 gatagagttc ttcaacgtct gctaattttt cggcaactaa gatagcttct tccaattcct
     4381 tggtcaactt accttgttct tgaatcttag ctaagacagc ttccttacgg tcattgagat
     4441 ttgtcagact tttatccaaa tcaataatag ccttaatcgc cacctcatcc agactaccag
     4501 tcatgtcctt gcgataacgc gcgataaagg gaatagtcgc cccttcagct gtcaaactta
     4561 gaacggtatc aatttgcttt aacatcactc ccaaatcctg agagattttt tcatattttt
     4621 tatccataaa tctattatac cacaagctaa acgtttcaaa ttaactcgta gaacatttaa
     4681 aaaatatgta ggaaatagat ttatatgcta cagcgcaata acttgcactt aaagagcatt
     4741 gccacctttt tttaaccaag ccatgatatc aaaagtattt aatggatcag acataatagc
     4801 cagttctgga agatgttcct gacctggaat aacacattga cttttcaaat ttttatatgg
     4861 acgattgact aaaattaatt tattagaata aggaagatta tccatcttat ttaaaatttc
     4921 ttcactagct gaatctttat tatcaaattt aaaataaaga ttattccaat ttatgcgttt
     4981 ttttcttttt tcccacttag ttcgtgcttc ttcaatacta gaataatgta gaaaatgaat
     5041 atctatatct cctaagtgcc ccaaaggata aacttcatga gtccagctcg gtgaaataag
     5101 ttcctcttcg aaaacaagtt cttgttccat ataataacga aaatgctttg taagtttata
     5161 ataatcatca ggaagaataa ataaaccaac aaaaggtgtt ctatattgaa aaccaagctg
     5221 tttataaatt aatcctccaa cacaattatt acttataatc gtaaaatcta atctatcaag
     5281 ctcaagaaaa gggaaaattc ctttctctgc agctattaac ttatgataaa caatatcaga
     5341 atctaaatat tcaccgtcat tttttaacca agcactaaaa tttgccaatt cttgaatata
     5401 ttgttttttc gctctttcta tatcatagtt ttctaagacg gcgcaatctt tgattctatt
     5461 ttcataattt tctaatatga ttttgtagga gtcttttaga ggtttagcat ctataacagg
     5521 tttatagata tatgtcggga aattaatata ggttgcagtt ttagagtgaa tataaagtct
     5581 ccaaataagg ttgtttatat caaattgatt tatttttcgt aaaagcttac tattgaataa
     5641 ttttccaaat aatgagcgat attgttttct aattcgatga tctgtatcat ccatcttttg
     5701 taaaacttga acattcgtta aattttctgt caaccaatta tccccccaag gataaaagta
     5761 aaatactcca tcaaccaaat cagcaaaatg accaagaaca acatcagaat cggataattt
     5821 tatcgcatga tacatctttt caaatgtcca atcaaataat gaatcatttg aagatagaaa
     5881 cgtaatataa tctcctgtaa tcatatcaga caactcagca aaagaattct catttataat
     5941 cttaatatta aatgatagat tcatctgttg gctaatggaa gctatctcct ctgtagattg
     6001 atttacaata ataacttcta tatcttttaa tgtttgtctc tccactattg acaaagactc
     6061 taataaacta tttttatctc cttgatgtaa caaaacaaca ctaattgagt aagtcagttt
     6121 gactacctcc cataattttc tgataatgat tttcttttta tttaattata gcacaattat
     6181 gatatatatc aggtaatatc aagctatatt atctcttagc tactcaattt gaaattttaa
     6241 cttttccctt ttccgcaaaa taatagtata atagaggtag aatttagaat cgaggtacac
     6301 ctatggctgt caaatttaca aaacgagacg acttggacaa gatgtttgaa gagtttgcta
     6361 aactccctga tttgaaacaa gttactttcc ctgatgacaa agagaaaaaa gtcaaagcag
     6421 aaaagaaaaa ctagatgact gcttttcaac aactcccatc tagtgtactt caaactggag
     6481 ccatttttct ctccattatc attgaagccc ttcccttcgt tctgatagga agcattgtct
     6541 cagggctgat tgaagtttat atcacacctg acaaggttta tcattttctc cctcgaaatc
     6601 gttgggggag aatctttttt gggacctttg tcggtatact tttcccttct tgtgaatgtg
     6661 gaatcgtccc catcatcaat cgttttctgg aaaaaaaggt tccaagttac acggcagttc
     6721 cttttcttgt gacagcacct gttatcaatc ccattgttct ttttgcgacc tattctgcct
     6781 ttggcaactc cttccatgtc gccctattac gagctctggg ttccattctt gtggctgtaa
     6841 tactaggaat ttttctagga tttttctggc aagaaccgat tcagaaagaa aatcgtctgg
     6901 cttgtcatga gcatgatttt tcttacttga gttctgcaaa aaaagttttt caagtctttg
     6961 tgcaggccat tgatgaattt tttgatacgg ggcgttattt ggtatttggc tgcctctttg
     7021 cttctataat acaggtctac gttccgactc ggattctgac ctctatcagt gcgactcctc
     7081 tttttgccat cctgctcttg atgcttttgg cctttcttct ttcgctctgt agtgaggcgg
     7141 atgcctttat aggtgcttct ctactctcga gtttcggttt ggctccagtt ctggcctttc
     7201 tcgtcattgg cccaatgctg gatatcaaaa atattctcat gatgaaaaat tacttgaaag
     7261 cacgatttat tagtcacttc attacgattg tgactctggt cgttttagcc tattctctct
     7321 tgattggagt catcctatga ttcgattttt agttttagct ggctattttg aactgactat
     7381 ttacctccat ctgtcgggca aactaaacca gtacatcaac atgcactatt cctatctggc
     7441 ctatatttcc atggtgcttt cctttatctt ggcaattgtt caattgtata tctggatgaa
     7501 gcaagtcaaa acccacagtc atctgaacag ccgattggcc aagatgacga gtatttctct
     7561 tctggctatt ccacttgtca tcggcttaac tttcccaact gttagcttgg attctcagac
     7621 cgtttctgct aaaggttatc atttccccct atcggaagga acggatctag ccattcagac
     7681 aagcgaaggg acgacaagcc aatatttgaa accagatacc agttcttatt tttcaaaatc
     7741 agcctatgaa aaggaaatgc gaacggcggc ggataaatac ttatcccaag atagtattca
     7801 gatcactaat gaaaactata tggaagtcat ggaggctatc tacgactatc cagatgaatt
     7861 tgagggcaag acaatccagt ttacaggctt tgtctataac gaccccagtc atgccaatag
     7921 tcaatttctg ttccgattcg gcattatcca ctgtatcgca gattctggtg tctatggatt
     7981 gctgaccaag ggcaataccc ggcagtatga aaacaacact tggataacag ccaaaggaaa
     8041 actggtcaat cactaccata aagaactcaa acaaaacctt ccaaccttgg aaatcgacag
     8101 ctttaccaaa gtcgataaac cagaaaatcc ctatgtatat agagcttttt aagaaaatca
     8161 agataaaaac gaacaagttc tcttctgaat aacagaaaaa gagcctgttc gtttttttgt
     8221 tatatgaaaa ttagtgactt gtagattttc atcttatacc atttccagca atacaagtag
     8281 ctcatagaaa ataagcgagc cactcattca ttagactagc gatttcttta ggtgcttgag
     8341 tataaagctc atggccaaag ttttctaaaa aaatagtatc aaaatagtct ggcaattctt
     8401 ttagggcttc ctctctccat gtagcttcat taggatagcg aggactaata aacaaggtat
     8461 ctcccacttc tctcttaaaa gcttgtattt ttctccgtag gcggagtatc gcttctatat
     8521 tttcataatt tatagccaac tcatatctat tatactcaac attccagtga taagactgtc
     8581 ttacagcttt ctccatattt tctgaccaat gctttgcttc agatttttct ttagaagtaa
     8641 gaacatctaa gtccaaaaca atttgagatt tgatataatt tttagtttcc tctaactctg
     8701 tatccaaagg taaaatctta tctaaatcta gatagccacc atccaaaaga atcagttttt
     8761 ttacttcttc gaattccgat gcgagataac gagctaaatc tcctccaaga gaatggccta
     8821 tcagacagat agattcttcc tcgctatgat aggcattgct tcccaaaccg ctaataaaat
     8881 attttttcat tctctactta atactatgct tattcatctt ttgttcaaag atagttgtga
     8941 taatctgacg caattcttcg cgttcttttt ctggaatctc accacttgtt tgagctacag
     9001 cgtagagttc agggtattca attgaaatgc gtttaatcgt acgtgttgta gcatgttttc
     9061 tgacaaaaaa cgggattcgc ttaatcaagt cttgtggtac tagcgccaga atcttctcag
     9121 tagtttcttt gtcactaata ttagacattg taagcctttt cttaatcatt tcctgttctt
     9181 tttctgtaaa atcttttaat tccattcgat tagtcctcct attttctcta agttaaatta
     9241 tgtactaata cagatgaaac tacaaagaat aaactttaag aaatcttctc actgataaga
     9301 ttttagcatt agacttcctg cgaaacaaaa tatggtatag tagttctatg aattatgaag
     9361 caagtaaaca actaactgat gcacgattta agcgtcttgt tggtgttcag cgtaccactt
     9421 ttgaagagat gttagctgta ttaaaaacag cttatcaact taaacacgca aaaggtggac
     9481 gaaaacctaa attaagccta gaagaccttc ttatggccac tcttcaatat gtgtgagaat
     9541 accgcactta tgaagaaatt gcggctgatt ttggtgttca cgaaagcaac ttactccgtc
     9601 ggagccaatg ggttgaagta actcttgttc aaagtggtgt tacgatttca agaactcctc
     9661 tcagttctga ggacacggta atgattgata gccattccca tcaatatcgt atctttggac
     9721 atagccaata aatgtttcat ttttgagtgg tttctggcta ttaacgattg aaataaccca
     9781 ccaactcatc aaaaatagaa ataaaaatcc taagattact gtcatatcat aacactatta
     9841 aagtttaacc cacttatcat tatccatgat aaaaggctta gccagtccct cgcctgtata
     9901 atccgcatac ttggtgccca aatacttgta gcaatcttcc ttactagcaa atttaatcgc
     9961 ttggtagggt tcttcgaaag tcaatttctc tacaaataag aaaccgtcat cagcaggtac
    10021 taagacccca acgtgaccta caaacagata ctcgccatcc agattgtcgt gcaagactac
    10081 agacagcatt cgagcttttt cattgaattg aaattgtgag aagaatgttt ccatcttttc
    10141 agcgtgaacc ttgacatctg tagttgcctc agttggaact ctcgaaaata gaatatcaaa
    10201 ctcttcctta tcttgtgaat caaagacctt tcctttatca atcgcatcat tatctaggaa
    10261 aagcaactgg tcattctttt caagctttgg aatggtgact gaatttttca aaagacaata
    10321 actattgata cggcagttgg ttccaacaaa atcgcccttc ttttgattcc agagatgact
    10381 gattttctca acatcgtatt cggtgtgagt aaaggaagtg aaatctcctg ataagccagt
    10441 tgagccgaca atggtattat agtcattaac gagattaaaa aatgcatcaa cactatttgg
    10501 atccaagtga gctgataaga gagatttgac ctcttctgta cttacctggt tgtttaggtt
    10561 ggtgtatgaa gctttccatg gaactttcgc tgaactgctt tgcctttgat tcgtcccctc
    10621 agaagtagca tgttgttgtt gacaagcagc caatcctaaa aacaaagctg aacagattcc
    10681 taatgtggct aattttcttg atttcttcat ttctttctcc taaatgtctt ggattaaagt
    10741 ttctttaact actgctttac agatattgat tactttctca tttaatgtgt tcatcgtctt
    10801 tccctccgat ttgttttttt gttatttcct taagcttgat ttaattatag taggcgttcc
    10861 gtgctctgtc aacaaatttt ttacgaaaac acaacaaagg ttttcatttt cgtggatttc
    10921 gtgttatgct ttacttacaa aaatagaaat cgatttcatt catagataaa gaagagattg
    10981 cgattgttag aggtgaaaaa cataatagat tgaaataaga tatgaacaac tctattagga
    11041 aaggcaaatt aattcctaga aatgttttag cagctacagc gtactattcc aaactcaatc
    11101 aactataaaa caatatagac tagtaatagt tggactcaat aagaattggg tactaagata
    11161 ggtataagta aaaacaccat tagaaattat gaaaaaaggg ttaggtctac taagaaaaat
    11221 actatatttg acttagttaa agtattcagt agcttgattg atgccctctt tcctccagtt
    11281 caaaaggatt ctcctagcga tatccaatct atctacgacc aacgggtacc acccagacaa
    11341 ggtaaagtcc tgacctatgc cgagaggcaa ctgtatgagc agaaaaacga agtatcgtaa
    11401 aaatcatcag actggacgac tacagacaga ctacttactc tcgtgttagg tagtttatct
    11461 ctgcagatag ccgctcgatg caggacaacg atttagatat ggagtttcca ttatcccaga
    11521 cgactacgac ccaatcgctt atgtcgtcag caagtccatg gagccaaaga taagaaacag
    11581 cgactaccta tttatcaaga ataccccaca gattgactat aataccatcg ggaaagttgt
    11641 caggctatat agggagaatt aaaaaagggg gagaatggcg atataaaaca aacagatttt
    11701 aaaagattcg aaaaactttg aaaaagttca ttctacattt caaaaaaaga ataagtgacc
    11761 taaagtagat tagattttgt taaacaatag tgatatgtaa atttagagaa aggcatttaa
    11821 catcactttg caaaaggcaa atactaaact agagaaaccg ataaaccagc cccttagttc
    11881 ccatattttc aggcacacac tccttagtac actagctgag aagaatgcta taatggttag
    11941 agtggaacac aaaaacgcta aaacagtaaa taacatctac actcacgtaa gtaaaagaat
    12001 ggagcaagct actttggagg ttttaaatac catatcatta aatcgaaaat atatcagatc
    12061 gaatctagac aagtacatta cgattgctaa aacatttgta gaaattcatt tgaatttcct
    12121 aatcaatttg tgcatatctt atttcatact caatgaaaat caaagagcaa actaggaagc
    12181 tagccgcagg ttgctcaaag cactgctttg aggttgtaga tagaactgac gaagtcagta
    12241 acatatatac ggtaaggcga cgctgacgtg gtttgaattt gattttcgaa gagtatcaat
    12301 ccattatgaa agttttgcct atttcttacc ctctatacaa aaagcctatc acacaagctc
    12361 taaagctgga tatgataggt ttttatattt ttcttaacgt actgtgcgga tacgcattgt
    12421 gtttgtgcga acagcttctc ctactggcac accagcaacg ataacgatat catcgcctga
    12481 ctcaacgaga cctgcttcta ccgctttacg ttcagcgatt tcgaacatat cgtcagttga
    12541 agatggagca tctgtcaaca ttgggataac accccagttc aacatcaagc cacgttctgt
    12601 caattcgtca aatgtcaatg ctaagatgtc agcatttgga cggtatttag aaatcaaacg
    12661 tgcagtatga cctgtcttag taagagttac aaccaatttg atatccattg agctagtagc
    12721 atctttaaca gcagaagcca ttacttctgt cttagagtta cgctcaaatg aatctgaatc
    12781 aagacgtccg tattcattaa gaagagcttg agcgttcttg tcgattgtag ccattgtagt
    12841 tactgactcg agtgggtatt taccgtttgc agactcgcct gacagcattg tagcgtcagt
    12901 tccgtcgata acagcgttga atacgtctga tacttctgaa cgagttgcac gtggtttttc
    12961 agtcattgtt tcaagcatgt ttgttgcagt gataacaact ttacctgcag cattgacttt
    13021 cttgataatc attttttgat aaactggaac catttcgaac ggtacttcga tacccatatc
    13081 accacgagca atcataatac catcagctgc ttcgatgatt tcgtctaagt tatcgatacc
    13141 ttgttggttt tcgattttag cgaacaattg aacatgtccg tttccagttt cttcacagat
    13201 tgcacgaact tcgttcacat cttttgcagt acgtacgaat gaaattgcga tgaagttgat
    13261 accttgttca agaccgaaac ggatatcgtc gttatcgcgt tcagcaagag ctgggaaagg
    13321 aattttagtg ttagggatgt tcacaccttt ttgtttagcg atgataccat cgttttcaac
    13381 ttcaacttca aattcacgag tttcatcatc tttagcaacc acacgaagac caagtttacc
    13441 atcgtcaacc aaaacttgac gaccaacttc aacatcatca tagatatcaa gagcaccagc
    13501 aacgttcaac gcaatcactt cacgagttga tttgattcct tgtttagttg caacacgaat
    13561 tttttcacca gttttgtatg aatattcttt agcttcacct tcgaacaatt ctgtacggat
    13621 ttcaggtcct tttgtatcaa gaaggaaacc aactttttta cctgcaattt tttccgcaag
    13681 tttaacagtt gccatacgct caccttgttc ttggtggtcg ccgtgtgaga agttgaatcg
    13741 gaatgtgtta gcaccagctt caatcaattt agcaatgttt ttagctgaag cttcaacatc
    13801 aagtttttca ccccagtatc cgtcctcacc gaatttttta ccaccacgga tttctaccgc
    13861 aggacccaaa gttgcaacga tttttacacg tttgttcatg atttttgtga ctcctttata
    13921 tatatgacct ttttggtctt attaactaaa ttgtaaatta tgacaagctc ttattcaagc
    13981 tagatagctc aatatcggct ttgtgtgggt tgttaaccac aatcttacct tctgcagtaa
    14041 ggctaaacaa tgccccttct tctgcagtac caagaattgg attttcaacc attttttcgt
    14101 tacgaatacc aaccgcaaca ccaccgatac cttctttaag aagtttaaca gcatgtgcac
    14161 ccatacgtga cgccaaaaca cggtcacgcg cagttggaga accaccacgt tgaatatgtc
    14221 caagttctgt tacacgaagg tcgcttgtat ctccagcttc tttaagtttt tgaccaaatt
    14281 cagccgctga catcacacct tcagctaaga cgatgatatt gtgtttttta ccacattcat
    14341 aaccagcttt gatgcttgct acgatatctt ccatcttgaa gtctgcttca gggatgatga
    14401 tttcatcagc accagttgca ataccagccc aaagagcgat atcaccagcg ttacgtccca
    14461 taacttcgat tacaaaagta cgacggtgac ttgatgatgt atcacgaatc ttatcaatag
    14521 cgtccatggc agtagtaacc gctgtgtcaa aaccgattgt aaagtcagta ccaacgatat
    14581 cgttatcgat tgtacctgga agaccaatag ctgggaagcc atgttcagtc aaacgcatag
    14641 cgccgtggta agatccgtca ccaccgataa caactacacc ttcaattccg tgttttttca
    14701 attgctcaat ccctttaagt tgcccttcaa gttgagcgaa ctctggataa cgagctgagt
    14761 gaagaaaagt accaccacga gaaatgatgt ctcctactga agctgcatct aggggatgaa
    14821 tttcaccggc aaccatacca gcatatccgt catagatacc aaacacttcc attccttctg
    14881 aaattgcttg acgaacaact gcacggatgg cagcgttcat accaggggcg tctccaccac
    14941 tagtcaaaac agcaatacgt ttcatattgg ttatgctcct ttttctttta acattcttac
    15001 tgattatacc acatttacgt tgaaaattct tctattttcc gtaattttag cgataaatcg
    15061 ttttcataac tattccattc aatttcgcct ctaattcatc agatttagct acaaaatgat
    15121 ggggagaaac gatggttttc tgttcctctt cataccggat gatgactggg attgggcctt
    15181 tatactggtc taaaatacgt gacatctctt gctccgagtc atgattttta agctgaatcc
    15241 aaaagcgttc agcaactgct tctcttattt cttgtgcaat catttgcaga cggccatcac
    15301 gtgattgtat ttttcctttt acatagtaga aggctccctc ttttatttcc tgtccaacct
    15361 gacgatataa gtctgaaaag agagtgacat ccaatttttt cttactatca tctgcctgta
    15421 agaaggccat attttcaccc tttttggtac gaatcacttt tattttccga acttcaacca
    15481 aaataatagc atagctattt tctgacaaat ttccgattgg ggtaatcggg taaatagcct
    15541 tacttgcaat agcttgtagt ggatgtttgc tgacacctat ccctaaaagc tcttgttcca
    15601 tataaaattt ttcttgttcc gtccaatctt ccgattcctg ccaactataa atagcatctc
    15661 caaacaaact tcccaactct ttcacaaatt caaatagatt agctaagtta ttaaatactt
    15721 tttgacgatt tttttcaaat aaatcaaaaa ggccaacttt taccaaaggt tctagcagag
    15781 gaagtttcag ataattctca ggtaatttag ctataaaatc ttcaatatta gaataaggtc
    15841 tatgttcaat aatccaaagc gccaagtcct tgctgagccc cttaatcgat ttcaaaccta
    15901 tatagataga cttgttggca attttatcgt gatagggaat agtattgatg gacaatgggg
    15961 ctacttcaaa acctgcttct aaggcatctg ttacataatc actgttggca gaattcaaca
    16021 taatctgata aaatatggct ggataatgtg ttttaaaata agccaactgg aaggccaagg
    16081 ctgagtaggc ataggcgtgt gacctgttaa aaccatagcc tgcaaacttc tccataacat
    16141 caaagacctg ctctgctttt tccacagtat gaccagcttc taatgaacct tgaataaagg
    16201 aagccctcat ctcatgcatg gcagaggcat cctttttccc catagcccga cgcaaaatat
    16261 cggctttccc aagactaaat ccggcaagtc gctgggcaac ctgcataacc tgctcctgat
    16321 agagcattat gccgtaggtt ggagccaaaa tatcctccag tactggatcc agaacagtca
    16381 cttcttcctg cccatgcttt cttgccacaa aattattgat atagtcacta gcacccggtc
    16441 gatttagaga agtagtcgcg acgacatctt caaaacagac tggttgcaca cgcttaagca
    16501 gacgaatggc acctggttgc tcaaattgaa agataccttt tgtattacca gaggcaaata
    16561 aagctaacgt ttctttgtct tctaaatcga tttcttcaat tttcagatga ataccttcta
    16621 tttcagcaag caactcttgc atcttctgga caaaggtcaa atttcgtagt cccagaaagt
    16681 ccatcttcaa aagtccgcta gcctcaactc catgagcatc atactgagtc agtggaattt
    16741 catcaccata ctttagagga atgtagttgg ttaaatcttg gtcactaatt acaacaccag
    16801 ccgcatggac agaggtttgc cttggatagc cctctatctt gcaagcaatc tcaaaagctt
    16861 tttggtattc taacttacta ttgatttgct gacgaaactg gagattgccc tcataggccg
    16921 acttaagatt gtcacgaaaa ctgattttct tagtaattgc agataattca tactctggca
    16981 caccaaagcg tttcaagaca tctcgaagag cttgcttggc tccaaaggtt gaaaaagtaa
    17041 cgatttgtgc cgcatgttta ctaccatatt tattaccaac atatctgata aaatctggac
    17101 gataaatatc tgggatatca atatcaatat caggcatggt atagcgttca cgattaagaa
    17161 agcgttcaaa aatcagattt ttctctactg ggtcaatccc cgtgatgtct aaggcataag
    17221 aaaccaaact gcctactgca gaaccccttc ccattcccat ataatagcca ttcgatcgtc
    17281 caaaacgcaa caaatcccaa acaaccaaga aataatcatc aaagcccata tcatgaataa
    17341 cagacaattc ttggtctagt ctatcttgat attctttact agtcaacccc ttctgaacaa
    17401 gccccagttc agcacgctct ctcaactcct ctactgctgg tctagctgga ttaaaacgag
    17461 gcagtttcag actagtatcc aagtcgtaag aaatgcctga aataagcttt tctaaattgt
    17521 ccaaagcttg cggaaaacgc tcttggaata gtttctctaa agaacttgct gatataaaga
    17581 catcttgtct cgaacgcaag ggaacttctc tgagcggtag attttcttta atcgctgtta
    17641 aaacttgaag aacttctcta tccctgcttt caaaagcgtt gacccgataa agaggtaaga
    17701 taggatgatg aaattcgctt gctagtgttt ctggataaac ccctatatag taatcacagc
    17761 ctagttctaa cgactcaact ctatcaaaat aaggcacaat gaccgcgata tcctccaggt
    17821 actgggacag gactgaccaa gttttctccc cctgcatctt ggctgtcgaa agcttcatca
    17881 actgctgata gcccacacta gatagagcta aaaagcgcaa attcacttcc tgatcatcta
    17941 caaacactgt catttcaagc cctagcaaag gatgaatgcc gtattttttt gtaatctcta
    18001 gaaagtcgaa agcgccataa agattgtcaa tatccatcat agccaaatga gtgtagccgt
    18061 attctttagc tgctctcaca tacttttcga tcgaaatgac gctttccata aaactataga
    18121 ctgtttttgt atctagttgt gcgatcaatt tacacttctc ctctatcctt ctcactatat
    18181 tataccattt tcacctataa atggcttctc ttgagaaaca tttcatcagc ttactaattt
    18241 attttctatt catttgtatt tttgtcatca tttttatatt tatactatat tgtatataaa
    18301 aatagaaagc atataatata aatctcctag aacttttata ccctatctat ttattcttat
    18361 tgttactctg ttctctatat tgaatttagt actttattca tttttattgg attatttcct
    18421 tttgaagtta acaattccct ttctgctttt tttttgatat aataacctta actgtcattc
    18481 tatatggagg ttctatgcgt tttaatcaat atagttatat caattttcca aaagaaaatg
    18541 tcttatctga actaaaaaaa tgtggctttg atttacaaaa tacagccaat cacaaagact
    18601 cacttgaaac ctttttacgt cgtttctttt tcacttatca agacaccaac tacccacttt
    18661 ctatcctagc agctgataaa aaaacagacc tgctgacatt ttttcaatca gaagatgaac
    18721 tgacagcaga tattttttat actgttgctt ttcaactttt aggcttttct tatttggttg
    18781 acttcgaaga tagtgacgtt tttcgtaaag aaactggatt tcccattata tatggtgact
    18841 tgattgaaaa tctctatcag ttactcaata ctcgcaccaa aaaaggaaat actcttatag
    18901 accaacttgt tagtgatggt cttattccgg aggataatga ctaccactac tttaacggca
    18961 agagtttggc tactttttct aaccaggatg tcattcgtga agtcgtttac gttgagtctc
    19021 gtgtcgatac tgaccaaaaa gggctatcag acctagtaaa ggttagcatt attcgccctc
    19081 gttttgatgg aaaaatccct gccatcatga cagccagccc ttatcatcag ggaaccaatg
    19141 acaaggctag tgacaaggct ctctacaaga tggagggcga gcttgaggtt aagcttcctc
    19201 acaagattga gctagagaaa cctcaactaa atctcgtcca accccaaggt aaagctgagc
    19261 ttatagcaga ggctgaggaa aagctaactc acatcaactc tagctataca ctaaacgact
    19321 acttccttcc gagaggcttt gccaatctct atgtctcagg tgttggtacc aaagactcga
    19381 caggtttcat gactaatgga gactaccagc aaatcgaggc ttataaaaat gtcatcgatt
    19441 ggcttaacgg ccgttgccgt gcctttactg atcacacgcg ccagcgtcaa gtcaaggctg
    19501 attggtcaaa cggaaaagtt gctacaacag gactttccta tctaggtacc atgtccaatg
    19561 gtcttgcgac tacaggagtc gatggtttag aagttatcat tgccgaggca ggaatttcat
    19621 catggtacaa ctactaccgt gaaaacggtc tggtgactag cccaggtggt tatccaggtg
    19681 aggactttga ctcccttgct gagttaacct attctcgtaa tctcttagct ggcgactata
    19741 tccgtggcaa tgaagctcac caagctgact tagaaaaagt gaaagctcag ctagaccgaa
    19801 aaactgggga ctacaatcag ttttggcatg accgcaatta tctgctcaat gcccataaag
    19861 taaaggcaga ggttgtcttt actcatggtt ctcaggattg gaatgtcaaa ccacttcatg
    19921 tttaccagat gttccatgct cttcctactc atatacacaa gcatctcttt ttccataatg
    19981 gtgcccatgt ttacatgaac aattggcaat caattgactt ccgtgagtcc ataaatgcct
    20041 tattgaccaa gaaattacta ggacaggaaa cagactttca acttcctact gttatctggc
    20101 aggacaatac agctccacag acttggttat cacttgataa cttcggtggg caagaaaact
    20161 gtgaaacctt ctcacttggt caagaagagc aagctattca aaaccagtac ccagataagg
    20221 attttgagcg ctatggtaag acataccaaa ccttcaatac agagctctat caagggaaag
    20281 ccaatcagat tactattaac cttcctgtga ctaaagatct ccacctaaac ggtcgcgctc
    20341 agctcaatct tcgtatcaaa tccagtacaa acaaggggct cttatctgcc caactgctag
    20401 aatttgggca aaagaaatac ctacaacctt atccagctat tttaagtgct agaaccattg
    20461 acaacggtcg ctatcacatg ttggaaaatc tctgtgaatt gccatttaga ccagaggcac
    20521 aacgagtcgt gacaaaaggt taccttaatt tacaaaatag aaatgattta ctgttagtag
    20581 aggatattac tgcagatgaa tggatggacg ttcaatttga actgcagcca actatttaca
    20641 agctaaaaga aggagacact ctccgtttag tcctctatac tactgacttt gaaatcacca
    20701 tccgtgacaa tacagactac cacttgactg tcgacctcgc tcagtccatg cttaccttac
    20761 cttgctaaaa ggagttacat tattatgaat aaatcagaac accgccacca acttatacgc
    20821 gctcttatca caaaaaacaa gattcataca caggctgagt tgcaagccct tcttgctaag
    20881 aacgacattc aagtaaccca ggcaaccctc tcacgcgaca tcaaaaatat gaacctatca
    20941 aaagtccgcg aagaagatag cgcttattat gttcttaaca atggttccat ctcaaaatgg
    21001 gaaaaacgtc tcgaactcta catggaagac gcccttgtct ggatgcgccc agttcaacac
    21061 caagtcctac taaaaaccct tcctggactg gctcaatcct ttggttctat cattgatact
    21121 ttgagcttcc ctgacgctat cgctaccctt tgtggtaatg atgtctgtct tatcatctgt
    21181 gaagatgcag atactgctca aaagtgcttt gaagaactga aaaaattcgc cccaccattt
    21241 ttctttgaag aataataaat gactacaact aacaattatg cttaaaaaaa actggtagaa
    21301 agtctttaac atcagaaaac gcatagtatc aagtgttgaa aacccttgat actatgcgtt
    21361 ttgctttatc ctaggaaaat ttatactctt cgaaaatctc ttcaatccgc gtcaacgtcg
    21421 ccttgccgta ggtatggtta ctgacttcgt cagtttcatc tacaacctca aaacagtgtt
    21481 ttgagcagcc tgcagctagt ttcctagttt gctctttgat tttcattgag tattatttca
    21541 ttttctcctg caattgaatt cttgctcggc tttttgtttt ctatttcttt aaaatcaaag
    21601 tagctctttt gttaataact cgatcaacaa acatcgtggt acaagtatct actttgaaat
    21661 ttatcagcca cttaacaact gatactgtat tctagaaaaa cgatgacatt cttcctaata
    21721 aaacttctca tatatagcat aaatttctac tctttttaat tttaaatgag tctcagcatg
    21781 gcaatcactt tagaatttaa gccgcttctc cagctcgatt attgataagt tcaatgattt
    21841 gaacaatatt acgaagtact ggtagttggt gttggaagag tagttgaaca gaaccataag
    21901 atttaaacgg ctcttgcgtt aacactttcg tctctaaaaa accattttct acaatgtagt
    21961 ctacaatcaa ttttacaaat gaaatctgcc tggcattaag attctcatcc gacaaaaatt
    22021 tagaaaaaat acgattggca gactctctat ctaagccaat aatctcacga accaatctcg
    22081 gaattgcctt attttcataa tgactttggt agtctgcttt actacctaat ttttcccaga
    22141 gcaatttttc aagtgcaagc atatcatcag atgtcaactt tttattatgg tatagcttag
    22201 aaatggactc ctcatccaga tgagttttca aataatgctc aactttttca ttgtaagacc
    22261 gaagatcgtt gacctgcaaa aatgctgtgg tctcgtgaac agtggagagt atacgatctt
    22321 caaagttaac atagtagggt ttacggtctg ttttatccaa aaactgtaat aaatctcgaa
    22381 tagcaagacg aattttttcc aaatcagaca agttaacttc tttccaaaat tcaggctcct
    22441 gtactttcct gataatttca gcctgctcaa aaacctgcgg gatattgcca atagcagaaa
    22501 gagctctagc cgtcttcatc acttgggaaa tatgaacagt ggaagattta gctgtcagtt
    22561 gccccaactg aatatgaagc aaccacaaat caaatctcct ggccatctca tcttctttat
    22621 cttcatcaaa taaaagcgga gagagatttt tttgaatggt ttcacttgta acagtagtta
    22681 gattctgcca actttccaat ttcctatagc tataaactgt atctaaaacc atacgaaccc
    22741 tgaagtccaa ctcatttaag ctctctatac gaccttgaag ttccgagaca agctgctgac
    22801 ggtatgctct cgcaaactga tcttcttggt attggagtcc ctgaagttct cgaatcaagt
    22861 ccactttgat attaaataaa cgctgagtca acgaaacaat gtgacgaccc tctccatctc
    22921 ttggatctgc acgaaaataa tcaaatacca agaagttttc cttatcctgc tcaggtccaa
    22981 ataaatcttt acatagacgg gttcctcgac caatcatctg ccaaaactta gttttagagc
    23041 gtactttctt gaagaagact aaattaacaa cctctggtac atcaatacct gtatctaaca
    23101 tatcgacaga aatcgcaatt tgaggatact tctccttaat tttaaaatca tcaatcaagg
    23161 tctgataatg cttaatacta taatcaatca cctgagcata gtcgctccct ttttcaggat
    23221 agcggttgtt aaaaatacct ctgatatatt ccgcatgatc atgattttta gcaaaaataa
    23281 tagttttacc aatttcatca cccgaggctg tctgaattcc tcttgtcatg agttcattta
    23341 aaacaatttc tactgtactt ttattgaaaa caaaggaatt aaatacactc ccatcaatat
    23401 ctttttcaca gctatcgtct tcaaatttgc tatcaaaatg ttccttttct tcttcggaca
    23461 aatcatcata atgtagacca tccgtaggta gtttcagttt ggtttcgata gaatgatagg
    23521 ttactaaata tccgtcttta acagcctctt ccaaatcata tgcatatgtt ggaaccccat
    23581 tctccaaatt aaagaatcca taggtgtttt tatctaaatc ttgacgcgga gtagctgtta
    23641 agcctacaat tcttgcatca aaataatcaa aaatggactt gtatttctga taaatagaac
    23701 ggtgagattc gtcaattatg ataaggtcaa aatgcccaac agtgaaaggg cgttgattta
    23761 cttcttcttg accactaatc gctccaatca tggtcggata agttgaaaag accatgcgac
    23821 ttgattgagc tccttcttta tcttctaaga agttacaaac ggaaagatct gggagtaatt
    23881 ttctaaacga atcataggct tgcttaacca aggaagttct atcggctaag aagagaacgt
    23941 tttttaccca gttatgacgt gataagatat caactagaga aactgctgta cgagttttcc
    24001 cagccccagt tgccataacc aaaagtgcct gtctacgatg attagagaaa gcttcacaaa
    24061 cgcttgcaat ggcatgtttt tggtagtgac gcccggaaat atcgtcccta attttactag
    24121 aaatatcctc aagtggtttt tgaagatgac gtctatccat cactaattgc aattcttctt
    24181 gagagtaaaa gcctgcaatc tggcggcggt tcggaccatc aagtatatag tgcttcaacc
    24241 catttgtaat aaagcaaatt ggctgatagc cgatatgttt ctccaaagct tcagcatatt
    24301 ctttgacctg tacttcccct acttctggat tgacagaggc ttttttagcc tccacaatcg
    24361 ctaaaatttt cccattttta ccataaagta catagtcaca gtaaccaatt cctgaaccgt
    24421 gcttgagacc atcaacggct atctcaacac gacagttttc ttcaaatatc catcctgcta
    24481 aacggagatc gatatcaata aagagctttc ttgtctctgc ctcagataat tgatcaatat
    24541 ggaaaggcac atcttgccgt tgcgctgcag tctcacgttt ttcagtataa gtctcttgaa
    24601 cttctacgga ctgagcagcc atctgttcat gaaaatcagg cagttctggt aaactgtctt
    24661 gtaactttat catagattgt ggagtttctc ggtatttgat gtttgctgaa agtggtaagc
    24721 acttctcatc aaaataacgc tccacaaatt cattgctgta acaataatcg ataaaattaa
    24781 caaactgata caaatgatgt aaagctaaaa tcgcttctcg ttccttaatt tcaccaccat
    24841 gagcagcatg gtttccccac cgaatcaaca gaactatctg cttgtggagt tcagaatcta
    24901 cgatatccct aaaatcatca tcccatacta aagaagatag agtagcacga tagggagctt
    24961 ctaaatatga atcgtgacta tatatccaat ggacagcctg ctctaaagca cgacgcgcca
    25021 taaaggcagt agccacagtt gatgtagcaa tcatattttc agcttcaatg caaggttttg
    25081 aaaaagattc atattcgtca ttttttaaaa gaaagctaaa atttcccatt tttttctcac
    25141 tttaaacaaa tagtttagct atattatact aaatttcaag ctatttctcc acacttttat
    25201 agctatctca caagcaaatt gtgatttgtc gacctggact acaaagtctg cgaactcatt
    25261 ttggagggct agtgggggga gggggagaag tatttttttt aattttgtaa ttggtaactg
    25321 aggctgagca cttcctgata tcactcgact ataattatta ttccttaaaa catggataat
    25381 aaatttctga tttagatttg gtgtcttggg acgtaatatt accatacctg aatttatacg
    25441 taaatgttta tattttatta attcatcgta gtacgctaca tttccaacag tacctcttgt
    25501 tgtcaagact atatcataac gctcaagttt gccttttcga agtaatttat cctttgtttt
    25561 agtgataaat tgctttgtat cgaatgaaaa tccgttttta gtaacattct ttgtatttaa
    25621 aaataaacag tactcctcac taaacaactc atctgattta ggataatttt tgcccctatc
    25681 accatctata atatcaaata agttatcaat gctttcaaat attttatttt ccccaaacat
    25741 ctcgttaaat cgggatttga cgagcaagtt tagttcatct aactgcaatt ttcttttagt
    25801 aataagcctt ttaatcgtat taagaataca gataatgttc tcttgttctt cgatacctag
    25861 caattctaat tgtaaatcaa gtaatatatt cttgtttaaa tgaggaattg ttgcacctgt
    25921 tgaatgatct cgtaaatact gcgatttact ttccaaaaag actcccaagt aatctgatat
    25981 aattttttct ttgtatcgct cattcttttt taagaccgta attgtactac caacagctcc
    26041 cgataatcca taaccaactg ttcctgcatt agctccatcc catgctatca gaatatcatc
    26101 tgggagtgct tcagtcatat ttaaactttc agtgaatttt aaattattat tatttcttaa
    26161 atcatctatt tgaatataac gttggcttag agttgtttgt tcagcaagta cagtggcttt
    26221 cttgcctttt tttagagata agacttcccc caacttcact tttttcatac agccacctcc
    26281 ctacttgagt aatttttcca attcagccaa gccagcttga atttcttttt ctaaatcatt
    26341 gattttcttt aatatgactt ctgttggttc atactcaact ttttcatact caatctcttt
    26401 atatttattg atagacaaat cataatcatt ttcctttatc tcagcaactg gaacaaagaa
    26461 agattgatcc gttctctgac gttctgcttc tttttcaaga tgatgaaagc gttcgataat
    26521 atctggaata tcattgtcgc taatcggttg tcgcttatca tccaaactta aaccatccgc
    26581 tttcatatcg taaaaccaga ttttgtcagt accaccatta ccagtttttg taaagatgag
    26641 aatggcagtt gaaactccag cataaggctt gaacacacca ctaggcattg agattacagc
    26701 atcaagctta tgattctcta caatttcctg acgaattcct ttatgagctt tagacgaacc
    26761 aaaaaggaca ccatcaggta cgataactgc tgctcgtcca cctggtttta aagttcgcaa
    26821 gaaaagagaa agaaagagta attctgtttt tttggttttt acggttgcaa gaaggtcatt
    26881 agaggttgaa ttgtagtcaa gtgagccctt aaaaggagga tttgctaaaa ccaaagtata
    26941 tttatcggct tcttcattat cttgagacag cgagtcaagg taactgattt gtggattttc
    27001 tactccatgt agcatcatgt tcatcgcccc aagtctcaac atagtcgtat ccgtatcatt
    27061 tccatgaaac atctgattat gaaaatgatt gatattatct gtattggttt cccattcatc
    27121 tttcttacgc tttaagtaac ggctagcaga tactaagaag ccagcagaac ccatagcggg
    27181 atctgagatg atatctttga tagtcggttg catcaactca accatcatat cgatgatgtg
    27241 acgaggtgta cggaactgtc catttttacc tgcggtcgac aattttgata acagatattc
    27301 atagatatct ccgatatcag taatactttg tttgtcatta tcaaaatcta catctaatcc
    27361 cctagttgga aaaacatcta agatagaaat tgccttttga agcgtagcag gtttatttat
    27421 ttgaaaaata gcttctcgca tatatcgtga aaaggctgta tcatctgtat cccccttgag
    27481 atttttaata aacggaaaaa tctcctgagt cattaaacga taaacttcct gagcatctcc
    27541 tatattttta aaagttgacc aacggtattc aggtttatct tttggaaaaa ctccctcata
    27601 aggaatccct agaaattcag catcactttc acgtccaagc tcgacactat ccaaatcttt
    27661 cataaataag agataagtca actgttcaat atttgttaaa ggatttgcgt ttccttctgt
    27721 ccaaagaatt tcccacagct gatcgatttt attttttaat tcgcctgtaa tcatatcttc
    27781 ccttttcttt agtttttaaa acttagtaat atcattattt tatcagattt caaacaaagc
    27841 ttcaattaac tatatctatg cgtcacctga atattttata ctcttcgaaa atctcttcaa
    27901 accacgtcag cttcaccttg ccgtaggtat atgatactga ctctgtcagt tctatccaca
    27961 acctcaaaac agtgttttga gaaacctgcg gctagcttcc tagtttgctc tttgattttc
    28021 attgagtatt aatagacttg tttggtatct tgaaaactat atcgtatagg tgtcgtcatg
    28081 gatcctttta gctgatttaa ggatacgcaa acacaatact atgactcaat tgaaatatta
    28141 aaattcaatt tctgaccacc taatcctgct tcaaatagtt atcgaacaag ttttatgata
    28201 gctaccttgt tgggatgctc ttatttttta tcagacaaaa caaaaggatt aagggagtta
    28261 atttccttaa tccgatagtt cttattcttg acgttgtccg aaatctgcaa tcatctgctc
    28321 catttcttgt cgactcggag tggtcagcat atacaggtaa tctccttgaa gttccgcgaa
    28381 ggcagctggc atgacttttt taaccttgaa ctgctggcta tatttggcaa gcaaatcctc
    28441 ttctgaataa acatagtgag catttgcacg gcgagaagta gccaaacaat actgagtttc
    28501 aaagtctgac gccgggaact cctctcctgc gacaatagct gcatagccac gataaaggtc
    28561 caagtaatga gcaaagttat aaacatcaat ggtaaaacca cctgcagggc ggttattgta
    28621 ctcgatggta atataatcgt ccccctcacg gaagaactca atatggaaaa accgttcttt
    28681 cataccaaat tctttgacaa ttgcttcccc atacttgcgc agtttaggat ccatatcctt
    28741 gagcacataa taagaattgt ccatcttata aatcatgagg tcaagcggtg tataggcgta
    28801 gtcaaaggtt gttgagaaga caatctttcc atccttgtcc acgagcccgt caaaggtaca
    28861 gatttcgctg gaagtgacaa atttttcaaa gaaataaagg gttgaatggt cccattcttg
    28921 cttgaagtga ttgatatcgt cttctgtctc aagtttaaag gttgcggctg ctcccactcc
    28981 attatcaggt ttggcaatca ttggaagacc gatttctttc actgcttgat caacatctgc
    29041 ttccgtcttg ataacagctc caggtaccac aggaacacct gcttttttga aaagtttctt
    29101 catttcagac ttatatttcg tctttttgag atcctctggt ttggcaccaa aaacattgaa
    29161 ttgttctctg agtgttgcgt ctagctcaag ccagtattca ttgtgagact cgatgcggtc
    29221 aattggacca tgtttataaa agagaaaagc aactgcacgt ttgacttcat ctatgttctc
    29281 aagattatca acacgaaaat actcggtcaa gctattgcgc aagggctcat ccaattgctc
    29341 gtaagactct tgaccaattc ccaagactgt gatgccttta ttagctagtt cgatggtaaa
    29401 ctgttgaaag ttttgtggat agtagggaga aataacaagg taattcatag gtaactcctt
    29461 ttataaatag agattaccga ggaaataagg catttgttta cgccaccatt cccagtcatg
    29521 ggcgacatca tgtccccatt cagcaaacca ggctggaatt tgtttcttgt caaaggcttc
    29581 tttgagcttg taaaaggatg acaaaccatc ttgttcccag gctccaagcc ccgtacacag
    29641 cacaatctct gcctgacggt aacggtcaat aaaccagccg tcgttttggt tccaaatata
    29701 atctactggc gagttttggt aaatagcatc atcgttgtag taatcaccga taaagaaacg
    29761 tgcgtcgtaa acaccactga gagcaatcac tttggtaaag acatctggat gctggaggaa
    29821 gaaattgagt gcatgatagg ctcccataga gcaacctgtc gtcatcatgc cataaaacca
    29881 acctgtcttg tgcttgataa aagaatggcc tcctcaatca cataacattc gtaggcacgg
    29941 tgcatttccg cttggtcatg agcatttttc caagtagcca accagctctc actatccaca
    30001 ctagataggg taaagaactg gacacggcct tcctcgataa aggaagcaca ggcatcaatc
    30061 atgccaaaat catagtattc gttgtgacta ccacctgatg aagcaaagac cacaactgga
    30121 atcccaccat gtccataacg gttaaggtac atttcacggt taggatgacc actccagtgg
    30181 ctaagatgtt caatatgcat ttcgtttttt cctttcttaa cttaccattt ttctgcaaaa
    30241 aatctcagac aatctggtag attttctgac caagggattt cactatggat ggcaccagac
    30301 tgaactttta gcacaagatt atccagatgt actccccctg ctatcaaatc atggtaatag
    30361 caaagcgacg agtcgatata ggcttgtttg atattgccat ccatcaaggt cttgtctgta
    30421 tcatctgctt cttctgttcc tacatagatg aagatgtgct ggtcaggcga tagtttctgg
    30481 cactcgatat agcggttaaa ggcttcttgg tggagccagt ttgcagatga aaaaacgccc
    30541 aagcaaccaa tttggtcttg gtattccaaa ccgataaact gggtaatatt gcctcctagt
    30601 gaggaaccaa tcatagccgt atgctggcag tctgcttttg tacgataagt ctcatcgata
    30661 aaaggcttga ccacctccat gacaaactca gcatactcca cacccttacc accaaactgc
    30721 tgctctggga taggagattc ttggaacttc caagccgcat actcattcat tcgccccata
    30781 ccatcattgt caatagcaac gacaatcatg cgactgatat ccggatttcg tttgatagct
    30841 ggaataatct tccatgaata tccaatgaaa gactctttgc tataaaaaac attttgcccg
    30901 tcatgaaagt atacaacagg ataggaacgg tctgtatctt tctcataatc tttaggaaga
    30961 agaatacgta cacggcgctc cttacctgta taaggaacct tgagtttgtg ttctttcatt
    31021 tttagataaa agtaggattg attcattgtc agaaaactct ctatattcaa aattttatat
    31081 cattatatca tgaaaataga aaaaagttag ttttttacct gtttttagaa aaaaaaacta
    31141 acttttttta ctgattttcg ctattctttt ggattttctg aattagagta gattatcaat
    31201 caagtcatca acttcatctt tttcggcttg aggtgtgatt tcagtaatca tgattccagc
    31261 cactgctcgc tcaaccaagc cttcaacatc catacgcgct tcgtactgct ccgcattctt
    31321 aattttagga tttgtttttg gacgatctgg tgcaaaaatg gtacaacagt cttcaaacgg
    31381 ttggattgaa atgtcaaagg tatcgatttc ctgggcgatg tcaatgattt ccaacttgtc
    31441 catggtaacc acaggacgaa tgatgggagt gttggtaaca gcattgatag ccttcatact
    31501 ttcaagggtt tggctggcta cttgacctag actttcccca ttgatgataa ccaaaccatt
    31561 tcgtacctca cgaatacggt cagtaatccg catcataaag cgacgagtta gagtcatcaa
    31621 ataagcttct ggcgctttgg ctttgatttc ctcttgaatc tctgtgaaag gcacctcgat
    31681 aaactggata tttccgccaa acttggtcaa tttacgggtc aagtcctgcg ctttcttgag
    31741 ggcaccagga ctagtatatg gtggactagc aaagtgaact gcctcgatat ccaccccacg
    31801 cttaagagca agataacctg ctacaggtga gtcaatccct cctgacaaca tgagcatccc
    31861 tttacctgaa gttccaactg gcaaaccacc agccccacga atggtttcat aagaaagata
    31921 ggctgcttct tcacgaatct ccacctgaag attgatgtca ggacttttca tttgaacttg
    31981 cacatttgga atggcttcga atacagcccc tccaagtgtt tggttgagtt cacgactatc
    32041 aagttcaaag ttgtggtcgc tacgcttgct agaaatctta aaggtcatac cttccttgta
    32101 gatgtcccgc ataatctctt ggacagcaga cttcaaaact tctacagatt tttcaacctt
    32161 ataaacagga gaaaagtttt gaattccaaa aacttgtttg agagattctg caactgctgt
    32221 gtaatcagct ccattgaggt aagcgtgggc acggtcgcga tctgctgtta ccttaacttg
    32281 gggatagata gacaaaacgt ctgaaatatt attgcgaagt ttattgatga aacgcatacg
    32341 atttttgccc ttggttgaca gctcaccgta gcgaatcata atttctgaat actgcatgaa
    32401 tgctcctatc ttacttttct agtttgattg taaattaatt ttagcttggt caagaactgc
    32461 tcgacctgac tcatatcatt ttcaaggtct agactaagac gcacagctga ctgagcctta
    32521 tccttgtcca ctcccatagc aatcagggtt ccggctggtt tcccagcctt ggacgaacaa
    32581 gccgaggtcg ttgagatgaa aatatcatag tcttcaaagg cgtgaacaat gacctcacca
    32641 cgaacaccct tgatttcaaa agtcagaata tgaggggcga agtcttcctc atctgaaaag
    32701 acaaatatat ccggatagtc cagaagtgct tgacgaatca ctgccttcat ctgcccagtc
    32761 ttgctcctaa agatatctag cttttccata gataaacgga gagccttagc ggtcgctgca
    32821 attcctgcca cattttcagt tgtcgaacgg taatcacgtt cttgaccacc acctgttaaa
    32881 agaggcgtaa tcttcttgcc agacttgata tagataaaac caacaccacg gattccgtgg
    32941 aacttgtgac cagagaaagt cgcgaaatcc actcgttctg tcagatactt ttcagtcgga
    33001 atcttggcaa gcgcctgaac cgcatcaacg tggaaggaaa tagttggctt gtctgccaat
    33061 agttttgaaa tagcctcaat gggctgaaca gagccaattt cattgttaac tgccatgatg
    33121 gaaacgaggg tcgtatcagg tcttatcaaa tcttctagcg cctcaacatc cacaaatcct
    33181 ttcttatcaa ctggagcaaa atccacttca aaaccttgag ctttcaacca gagggctgat
    33241 tccttaactg ctggatgttc aatggctgat acgatgatgt gcttgccaaa ctgggctttt
    33301 tcaaatgcta ctcccttgat gatccagtta tccccttctg tcccaccaga tgtaaagaag
    33361 atttcatcac ttttcttacc gattaaatct gcaatctgtt gacgggaagc atctaaaatt
    33421 cgtgttgcct ggtctcccaa acgatggaga ctagatggat ttcctaaaat ttttgaagcc
    33481 acctgcatat aggtttcaag ggcttctgga tagggcctgg tcgtcgccga attatcaaag
    33541 taaatcatgt ttctcacgct ttctaaaatc actccttcta ttgtatcatg aaacggagct
    33601 tgcgacaaga aagggcaatt tctctttttt taagattttt ttaaagaaac agagtataat
    33661 aagtcataat caaaggagag aatgtatgtc taactatcgt agaacttcaa aaccgaaaac
    33721 agaacatatc aaaaaaggct ttactgtttt tcaaaaaacc attactacta tcggtagtat
    33781 ccttggtttg attacagcgg gtatcacgat catgaacgcc ttggataata ataataaaaa
    33841 tactaaaaaa gaacctacga caagccagac gacaaccttt gtcaaagaaa ttcaaaaaga
    33901 atcccctcag gaaaatacta ctccaaataa ggaaaataac acttctcaag aaaaaacaca
    33961 acaagaagaa acgccaaaat ctagcgtcaa ggaagagaaa aaagaagatc agaaaacagc
    34021 aactcaggac tctactacac ctgctacaag taaacctgcc actgaaaatg aaaaacagcc
    34081 cactactcca acttcagaaa ataatactca atgaaaatca aagagcaaac taggaagcta
    34141 gccgtaggca gtacttgagt acggtaaggc gaagctgacg tggtttgaag agatttgcga
    34201 agagtataaa agtaatcaat agccagtaaa atagctcctt ccaaccttgg aaagaagcta
    34261 ttttttattg ctgcaatact tttcttggct tggtaccttc agctggacca atgacacctg
    34321 ccatctcaag ctcttccatg agacgggtcg cacggttaaa tccaactgac aaacgacgct
    34381 gaatcatgga tgcactggct ttctgtgttt cgataaccaa agacttagct tcttcaaaaa
    34441 gcggatcacc accagcatct ccatccgaaa attctccttc attttcagaa acctcacctg
    34501 gatcaaaact ctcatcgtag tctgcatctg cctgagcctt gatgaagttc acaatgcgct
    34561 caacatcgtc atccgagata aaggagcctt ggagacgaac tggatgattt tcatcaatcg
    34621 gtttaaagag catgtctcct cgaccaagaa gtttttctgc tccattttca tccaaaatcg
    34681 tacgggagtc tgttcctgat gaaaccgcaa atgctacacg agatggaaca ttggccttaa
    34741 tcaaaccaga gatgacatca acagatggac gctgagttgc aagaatcatg tggatacctg
    34801 cagcacgcgc cttctgccca agacggatga tagcatcttc cacttccttg ctggccacca
    34861 tcatgaggtc agccaactca tccacaatca cgacaatgag tggtagcgga atttgcttgt
    34921 actcagactg ggaattgaac tcttctacct tggcattaaa acctgcaata ttccgaactc
    34981 ccaccttggc aaagagttca taacggcttt ccatttcatc cacaaccttt tgcagagcct
    35041 tgctggcttt gcgtggattg gtcacgactg gaatcaagag gtggggaata tcattgtaaa
    35101 cagataactc aaccatcttg ggatcgacca tcataaattt aacttgatct ggtctcgcct
    35161 tcatgagaat gctagcaata atgccgttaa ctgctactga cttccctgaa cccgttgaac
    35221 ctgcaactag caagtggggc attttagaaa ggtcaaaagc tcttgcggtt ccattaacag
    35281 ccttccctaa aggaatttcc aagaaatttt ctgctttcgt ttgcgattgt tcccatagtt
    35341 ctcggaaaga tacagtggta atatcggagt taggcacttc aattccgatt agggatttcc
    35401 cagggattgg tgcttcaatc cggacatcct tggcagccaa ggctagagcg aggtcatctg
    35461 atagattgga aatgcggttg acccttacac caacagccgg cttgacttca tacttggtca
    35521 ctgatggccc aatttcggcc cgttcaactg ttaccttaat accaaagcta gcaaaggttg
    35581 cttctaagat tttgatattt tctctgacaa ttttcttctc tttagactga tcttttggtt
    35641 tatctggtgc aaagagttgt aagcttggaa gtttgtattc aagggcttct ttggctgaaa
    35701 aatcgacctg aacatcttcg tcatctgagt catcttcctg ttcagggaat ttaagttcag
    35761 cttgaggcag gatgatttct ggttccaccc acttttcttc tggaataggt ggaagatttt
    35821 gaacagcttc ctctgtcaga atttcacccg tttccatatc aacaggaggc aaatcgagta
    35881 aggctttttc agtctcttct tgttctaatc tagcctcttt ctcagccttt tggcgagctt
    35941 tttcttcttg tttgacaaag cgttcctctt ttcgacgctc gtgcccttcc caccatttgg
    36001 caaagcctct actgaaaaat tcagcaatat cgtaaacaga ccaagggctg actaggagag
    36061 aacccactaa aatcaagata gaaccaataa agtaagttcc gatatttgaa aagagaaagg
    36121 ctgttggaat ataaagagcg accccgatca agccccctcc agcaaagcta gtcgttcgaa
    36181 aaccagtcag atctgtcaca acctgagcca tggtcccttt tagaacggac ttgtccaaac
    36241 catatttcca aaccaagtag gcctcaaaaa tcaagagtaa gccagcaaat atggtgaaaa
    36301 agccagataa gagtccttcc tgttttcgta tccacttgaa aaagaagaga tagattaata
    36361 ggccgaatat cgccagataa gctaggctac ccactagcaa gcgaattaaa ttataaaggg
    36421 ttatacctgc agcccctaat ttgaaggctg cgaaaatcaa taaaatcgca attcctaacg
    36481 aaatcaacat tcgttgaatc gcttcttttc tttccagttc tgctttagac ggtctccgtc
    36541 ttgttgtact tgtattcttg tttgccattc ttctattata ccatatttca caggcatttc
    36601 gggaagagaa aaagactgca ccaaacggtc caatcttttc atttttctat tttttatgct
    36661 tgtggtttgc gtaggtaacc ataaaccaca ccacttacga ttgctcctac caagacagaa
    36721 acgaggtaaa ggagagcatt tgaagtaagg gcgataacga agattcctcc gtgtggcgcc
    36781 atgagtttga taccagtaag accaacgagt ccacctgcta ctgctgaacc aaggatgaag
    36841 cttggaatcg cacgagctgg atcagcggca ccaaatggaa tcgctccctc agtgataaat
    36901 gacaagccca tgatgatgtt tgtcaaacca gagttacgtt cttccttagt aaatttatct
    36961 ttgaaaagaa gagttgcgac aaagattgca agtggtggca ccattcctcc agccataact
    37021 gctgccatgg ctacagaacc acctgaagaa acagttgctg caagcgtacc tgtaccaaag
    37081 acataagctg ctttattaac tggtccaccc atgtcaacag ccatcattcc accaaggacg
    37141 ataccaagaa ggacagctga acctcctcca agaccgccta ggaagtcatt catagcagtg
    37201 ttgattgcag ccattgggat attcacagct agcataacaa atcctgtcaa gattgttcca
    37261 agaagtggca atagaaggat tgatttagca ccttcgagtg aacgaggaac tttaacgtat
    37321 ttcttgatgg caagaaccaa ggcacctgcg ataaatccac caacaagggc acctaggaaa
    37381 ccagatgaga cacctgcaag agttgaagtt gcttcaccac ctgcggcata aggaatttta
    37441 ccaaaggcaa aaccttcttt ggcaatagca ccagccacga aacctgctac caaacctggt
    37501 ttttcagcaa tagagtaggc aacataaccc gcaaagactg gaagcatcaa accaaaggca
    37561 gctccaccaa ttttcatgaa catagaagct aactcatggt aagaaccaag attgccaagg
    37621 ttttcatttg gaacactcaa agcaccgtca atcaagaagg caagggcaat catgatacca
    37681 ccaccgataa cgaatggtaa catttgagat acaccactca tcaagtgttt gtagaaggca
    37741 ccaccaaggc tttgtttttc gttagaggct gttgcagctt ttgcaccatt agcggcacgg
    37801 tagacttcag tatctcctga aagagccaag ttaattagct cttctgtctt acggataccg
    37861 tcagcaactg gacgattgat caatggtttt ccatcaaatc gatccatttc aacggccttg
    37921 tctgctgcaa tgataatagc tttagcctta cggatatctt ctgcagttag ttgatttcca
    37981 acaccgctag caccgttggt ttcgaccttg ataccaaccc ccatttcagc agctactttt
    38041 tgaagggctt cttgggccat gtaagtgtgg gcaatacctg ttgtacaagc tgtaacagct
    38101 acgataaagt caccagagtc attagcaggt gcttgaacaa gttcctcagt tttttctgaa
    38161 gcttggtcaa aaagttcgat aacttggtct gcagatgttg cttgacgaag tttgtctgca
    38221 aaaccgtctt tcatcaagta ttgagacaat tctgccaagg ctgccaagtg agtatcattg
    38281 gcaccttctg gagctgcaat catgaagaag aggtcagttg cttgtccatc caagctctcg
    38341 tagtcaacac ccttatttga cttagcaaat agaactgtcg cttctttgac agcagcgttt
    38401 ttgctgtgag gcattgcgat tccatcaccc aaaccagtag aagtcaaagc ttcacgcgcc
    38461 aaaattcctt ctttaaatgt ttcaaaatct gttacataac cgtgctctgt caaattttta
    38521 atcatctcgt cgatgacagc tgttttttca gttgcctgca aatctagcaa catgacatct
    38581 tttctcaata ggtcttgaat tttcatcttt tttctacctc aacttttcca tatgtttctt
    38641 taataaattc cgccgttgcc aagtcatctg agaaggtagt tgccgttccg caagccactc
    38701 cccatttgaa ggcttctact acgtcttttg atttgacaaa ttcacctgtg aatccagcaa
    38761 ccatagaatc accagctcca actgaatttt tgactgttcc tttgattggt ttagcgaagt
    38821 aagctccctc agatgtgaca agaagggcac catcaccagc catagagata ataacatttt
    38881 gagcaccctt agccagtaac tcacgagcgt atttctcaat ttcatctaaa ctttcgagtt
    38941 taaccccaaa aatcgctcca agttcatgat tgtttggttt tacaagaaga ggctggtagt
    39001 ccaaactatc aattaaggtc tgtccttcaa agtcacagac cacttgcgca ccagtctggc
    39061 gcgtcaagga aatcaaatcc ttatagataa cattgcctag atttttagca cttgaacctg
    39121 caaagacaac tgtatcttct gctgtcagac tagataaaat agctttcaat tcttctagct
    39181 gaaccgattc aacagttgga cccgttccgt tgatttctgt ttcttggtct gctttgattt
    39241 taacattgat acgagtatct tctgccacct ggacaaaacg tgtctcgatt tcttcctctg
    39301 ctaaagtatc tgtgataaat ttaccagtaa agccaccgat aaatcccgtc gctgtatttg
    39361 gtatattcaa acgtttcaag acacggctga cattgattcc tttcccacca gcaaacttat
    39421 catcactgtc catacgattt acactaccaa ctttgacttg gtccaaacga acgatatagt
    39481 caatggatgg attgagtgtg actgtataaa tcatacttct attacctccg ttttctcctt
    39541 aataacctgc aagagctcat gcccttgact agtgataacg atagcgcgtt tgagtggtgc
    39601 taccttggca aagcaagttt gtccaatttt tgacgaatcc accaagacgt aggtctgctt
    39661 ggcattctcc aaaatagctc ttttcacagc tccctcctcc atatcaggag tcgtataata
    39721 gccatcgtca acaccattca ttccgataaa ggcacggtca aagtgcaatt ggttaatctg
    39781 gttaagagca acgcccccga tactagcatc tgtcgccgtc ttgacgtttc ctccaaccat
    39841 gacagttgga atctgctttt caaccaactg agcggcatgg tgaatggagt tggtcacaac
    39901 tgtaacattc ttattgacca attcatgaat caaaaaagca gttgttgttc cagcatcgat
    39961 aaagatgaca tctttttctt taatgagaga ggctgctttc tgagccagca acttcttttc
    40021 ttgaaggttt ttgacagatt tttcttgaat ggtttcttct tcctgtaagg agtaggggag
    40081 ttctgctcca ccatgcacac gacgaagctt gttttccgct tccaactcat ccaagtctct
    40141 tcgaaccgtt gattctgacg tttctagcaa actaactaat ttttctagag aaactacatg
    40201 atgctgattt aactcctcta aaattagttg tttacgttct gtttttaaca ctgaatcacc
    40261 tcctgttatc gtttacacta ttcattctat catactttct ttcgaagtca agcatttttt
    40321 atcattttct ttcaaaatct atcatttttc ttatttctag aatttttatt gcaagataag
    40381 agcctttatg gtagactatt tgagtaagta ttggaagatt actcaagagg cttaagaggc
    40441 cgtgttggaa acgcggtagg cgtgtaatag cgtgcgtggg ttcgaatccc atgtcttccg
    40501 tggaaaaaag attattttta ggatgcgaca aatgttgtat ccttttttct atcctttttt
    40561 taaaataggg tctgtttgtg actccctttt tagcaaaaga atgcaaagga ataccaaaga
    40621 taaaaataaa aaacgttgat ttaacaacgt tttaccaagg aatgcaaaag aatgcaaagg
    40681 aataatggag ccggtgggag tcgaacccac gtccaaacac ctgccaacat atttgtctac
    40741 aaccataggt tatgtattat tttaacagcc cctcgacaca taactcaagt ctagaaactg
    40801 cgagtctatc aatctcttat caagccgcta gacaaggctt aatcgtatct cgctaataat
    40861 aagacctgtc attgaacacg agcaatccaa atcgggtcac gcctgctggt ttttaggcag
    40921 ctagagcgta agaagtgtta ttttttgcag ttatatttaa ctgagcgttt acgtcgccac
    40981 acgagtcgca aaatatgcct cataatgcct gtcgaatccg taacgacccc aaaagacaat
    41041 aaaaccatta taccttatct aactcaaaaa tgcaaaaaga aatcacatac ctaagatgaa
    41101 gctatctgtt ttgaagaaat tcacgaagag aattattcta aaatactttc agatgagaat
    41161 tttcgtactc tctttatttc aattcatttg agtttaaaaa ctataaaatc aatccttata
    41221 ttattcgatc tacttttcac ttattgcacc aaaatatagt aaaatgaaat aagaatagaa
    41281 cgaatagata aggacagtca aatcgatttc taacaatgtt ttagaattag aggtgtacta
    41341 ttctagtttc aatatactat aaataggttt cattcgaact ttaatagact atgaaaacca
    41401 gtggaactta ccctgacacg gaattccact ggttttttcg atttttatca gattaacttc
    41461 tactattctt agctgtgaaa attagtttaa gactttaact tattttcagt cttctaatct
    41521 aaaggccact tccagtaaag aaaaatcagg gttctcctga cttttactta gctaattctc
    41581 tttctcgttc tttcattatt ttatgatttt catacaaacg ggataagaac ttagaaattt
    41641 ctttcaagat agaataggtt ggcactgcga caatcattcc aactacacca tagatattgc
    41701 ttgacaacaa aagtaaaact aaaatcgtga ttggatgaac cttcataaca cttcctacga
    41761 ttcgaggata taagatattg ccatctacct gctgaacaac aagcatataa atcactgcaa
    41821 tcagcagtct atggggatca gtgaatatat ttgcgatgat cataggaatc aaaccaatac
    41881 ttggccccac ataaggaatt aaattggcta caccagaaaa aatggcaaaa actaaagcat
    41941 attttaaacc aataatacta tagccaatat aagctaaaca acctataatg attgcgtcaa
    42001 tcgaaactcc actaatatag cgagcaatcg tcgcatttaa attctttaat aagcctgcaa
    42061 tatgcaagcg atccctcttt agaatcgttc tttcaagcat gggcaagaat ttatgtccat
    42121 ctaataagaa ataaaccaaa aaaactggag tcataatcaa aatcaaaaca gtactgataa
    42181 gagctgacaa gacgctcccc acactatttg atacgctatt taggatattt tgaagaatat
    42241 caacatagga taagtttaac tgctgaattg tagcttctac atccaaattc tggagcgcag
    42301 gataattaga taagtctatg attaagtctt gtactcgact ataaatagtt tgactagata
    42361 taatcaaact agataactga ttaatcaaaa taggtaagag atagacaaca cctatgacca
    42421 ttccccagac caaagtacac aaggtaatta aaataccaag caaacgattg agtttacaga
    42481 ctttatttaa gaaagtaaca atagggtttg tcaaataata aagaaagccc cctaataaaa
    42541 atggaatcat aattgtatta agcacgctaa caaaagggtt aatcaaagat cccatctgtc
    42601 tccataggta aaagatgatg gttaagagta aaatttctgt ggtccaaaaa aataatttat
    42661 ttctacgaaa catgagttac ctccctcact ttattttacc atattttcaa aaagcttaac
    42721 agatgaatta ttaaagcaag aatatttttt ttctttatga tagaataaga ctactatgaa
    42781 aaaaacattt ttaactttat taactgtctc tcttttaggg ggtgcttcta ctgctgttgc
    42841 tcaagatttt accattgccg ctaaacatgc gattgctgtt gaggcaaata ctggtaaaat
    42901 tctctatgag aaggatgcaa cgcaacctgt cgaaattgct tccataacaa aattgattac
    42961 tgtttatctg gtctatgaag ctttggaaaa cggaagtatt accctctcca ctcctgtaga
    43021 tatttctgat tatccttatc aattgacgac aaattctgaa gccagtaata ttcctatgga
    43081 ggcccgtaat tatactgtcg aagagctgct tgaagcaact ctggtatcta gtgccaacag
    43141 cgccgctatt gccctagctg agaaaattgc tggctcagaa aaagatttcg tcgatatgat
    43201 gcgggcaaaa ctcttggaat ggggaattca ggatgccact gttgtcaata cgacaggtct
    43261 taacaatgaa actctagggg ataacattta cccaggttct aaaaaagatg aagaaaataa
    43321 gcttagtgct tatgatgtcg ctatcgttgc tcgcaacctc atcaaaaaat acccacaagt
    43381 cttagaaatc accaaaaaac cttcttctac ttttgctggg atgacaatca cttcaaccaa
    43441 ctacatgtta gaaggtatgc ctgcttaccg tggtggtttt gatgggctaa aaacaggaac
    43501 aacagataag gctggagagt cttttgttgg tactactgtc gaaaaaggca tgagagtcat
    43561 cacagttgtt ttaaatgcag atcatcaaga caataatcct tacgctcgat ttacagctac
    43621 atcttcccta atggattata tttcttctac atttacactt cgcaaaatcg ttcaacaagg
    43681 cgatgcctat caagatagca aagcccctgt acaagatgga aaagaagata cagtaactgc
    43741 agtggctcca gaggatatct atctaataga acgtgttggg aatcaatctt cccaatctgt
    43801 tcaattcaca cctgattcca aagcaatccc agcaccactt gaagctggaa cagtggttgg
    43861 ccatttgact tatgaagaca aggacttgat tggtcaaggt tacatcacca cagagcgccc
    43921 tagtttcgaa atggtagcag acaagaaaat tgaaaaagcc ttcttcttaa aagtttggtg
    43981 gaatcagttt gtccgctttg ttaacgagaa attataaaaa atcgcgattt taaaccgcga
    44041 ttttttgata taagttcatc ttcaaaatca aagaacaaac taggaagcta gccgcaggtt
    44101 gctcaaaaca ctgttttgag gttgtagatg aaactgacga agtcagtaac catacataca
    44161 gtaaggcgat gctgacgtgg tttgaagaga ttttcgaaga gtataaaatc aaattttatc
    44221 caactgatcc ctccatttca tagctaatca agcggttcag ctcaactgcg tattccattg
    44281 gaagttcttt tgtaaagggt tctacaaatc ccatgacaat catttcagtt gcctcagatt
    44341 ctgacaatcc acggctcatg agataataca attgctcttc tgaaatctta gatactttgg
    44401 cttcgtgttc caaagccact tgcgagttgt gaatttcatt aaatggaata gtatctgatg
    44461 ctgacaagtc atccatgata atggtatcac attcaatgtg ggaaacagat ttcttagagt
    44521 tcttgttaaa ggtgacttgt ccacggtagt caacctttcc tccaccttta gcgatggatt
    44581 tagacacaat agacgagctg gtatgtggag cattgtgaat catcttagca cccgtgtctt
    44641 ggtgttgccc tgcattagca aaggcgatag agagcatggt accacgcgct ccttctccat
    44701 caaggtaaac agatggatat ttcatagtcg ttttggcacc caagtttcca tcaatccact
    44761 caacagtggc atccttttga gccttagcac gctttgttac caagttatag acgttatcag
    44821 accagttttg gatagttgta taacgcatat aagctccgtc caaagcaaaa atttctacaa
    44881 tggcagcgtg caagctatta cttgaatatg ttggtgctgt acatccttct acgtagtgga
    44941 cgcttgctcc ctcatcaacg ataatcaagg tacgttcgaa ctgacctata ttttcattat
    45001 tgatacggaa ataagtttga agtggaatat ctaccttgac accttttggc acgtagataa
    45061 aagttccacc cgaccatact gctgagttga gggctgccaa cttgttatct gtcggcggta
    45121 ccaacttcgc aaagtattgt ttaaataagt ctgggtattc cttgagtgcg gaatctgtat
    45181 ctgtaaagat aatacctaat ttttggaact cttccttcat gttgtggtaa accacttctg
    45241 actcgtactg ggcagaagcc cctgctaaat aagcacgttc agcttctgga atcccgatac
    45301 gttcaaaggt ttctttaatc ttttcaggta catcatccca agaacgggct ggtttgtcag
    45361 atggtttttg gtagtagatt aagtcatcaa agtcaatctc tgacaagtct gctccccaag
    45421 tttgcatggg catttttttg aaggtttcat aagacttcaa gcggaactcc aacatccact
    45481 caggctcacc cttagcagca gataattcac gaataacacc ttcgttgagt ccttttcctg
    45541 tcgataagac aggctctaca tcgtcatgga aaccaaattt atattcacca aggtcaattg
    45601 gttttggttc tactctttct tcagccataa tatcctttct ttcttcattt ctaataattc
    45661 ataagacaaa agaaacttgt cttactgttt ttcttgattt tcaattgttt tcttaagagc
    45721 attccaagct agggttgcac acttgattct ttgagggaat ttggcaacac ctgacaagaa
    45781 tgccgcatct ccaagttggt cttgacgctc atctttttgc ccttgaacca tttcagaaaa
    45841 aatagtcgcc agttctaaaa tttcttgttt ggtttttcct aaaacggcat ctgtcatcat
    45901 actagcagaa gcagttgaaa tcgtgcatcc tgaatttaga aaagcaatat cttccaaacg
    45961 gtcctctgca tcaaacttga cagagaggtt gatgacatcc ccacaagtcg gattgttgag
    46021 actgatttgc tcagcgtctt ctaacttccc ttggtgatgt ggatttttcg aatggtctgc
    46081 taccactgcc atataaaggc tatctagttt agaaagtgcc attgaaaaac tcctttgtct
    46141 tttgtagggc atcgactagt ttgtcgcaat ctgccttggt attatagata taaaaacttg
    46201 cacgagctgt tgctgggact tccaaatact gaagcaaggg ttgcgcacaa tggtgaccag
    46261 cacgaacagc cactccttca taatccagag ccgtcgcaag atcgtgagga tggagatcac
    46321 ctaggttaaa ggcaataaca cccgaacgtt gagccaaatt ctgagaaccg taaatggtca
    46381 atccctcaat tgcctgcagt tttggataga cgtacgcaat caattcctgt tcatgagctt
    46441 caacggcatc cataccaatc ttttccagat aatcaactgc agtcgcaagt ccaatagctc
    46501 ctgccatatt tggcgttcca gcctcaaatt tccaaggcaa ttccttccaa ctagcagatt
    46561 gctcgtagac aaaatcaatc atctcgccgc caaattctac tggagacatt tgctcaagat
    46621 acttttcttt gccgtaaagg acaccgatac cagtcggacc agccatcttg tgacccgaaa
    46681 aggcgaaaaa gtccagatcc aagtcctgga catcaatctt catatgaggt gtagattgag
    46741 caccatccac taccatgatt gccccaactt ggtgggctaa ttgagtgatt tccttgatcg
    46801 gattgaccac accaagaaca ttggaggcat gagctaggga aacaaattta accttatcag
    46861 tcaatttagc tcgcaaatcc tccatatcca aggcaccgtc tttaagatag acatagacaa
    46921 gctctgctcc agtctttcga caagcttcct gccatggaat gatattagaa tggtgttcca
    46981 ttactgaaat caagacctgg tctccctcag cgagaatttc ctcagcaaag cgtgccaccc
    47041 agttaaggct ggttgtcgtt cctctggtaa agagaacttc ctttgtagag cctgcattaa
    47101 taaacttacg aatggtttca cgagcagctt cataagaagc tgtcgctcgt tccgctaagg
    47161 tatggacacc acggtgaaca ttggcattgt cctgctcata gtaactgtta atagctttca
    47221 gaactactag tggtttttgt gtcgtcgcag cattgtccag atagaccaga ggttcatcat
    47281 tgacaatctg atctaaaatt ggaaaatcct tgcgaatcgc ttctacatct aacataggct
    47341 tccccttagc gttttgacaa tttctcttcg atagttgcaa tcatttcatc acgaacttcc
    47401 ttgactggaa tctccacgat aacagatcca aggaaaccac gaacaaccaa acgctctgca
    47461 gttgccttat ccaatccacg actcatgagg taatacatgt cttctggatc aacttgtccg
    47521 atagacgctg cgtgtcctgc agtgacatca ttttcatcaa tcaaaagaat tgggttagca
    47581 tctgaacgcg cttggtctga aagcatgaga acacggctct cttgttgcgc atctgctccc
    47641 ttagcaccct tgatgatgtg gccgatacca ttgaaagtca aagttgcttt ttcaaggata
    47701 accccatgtt gtaggatatt tccgatagag ttgcagccat agttagttac acgagtatca
    47761 atcccttgta cctgacgacc acttgaaaga gctacaacct tgaggtcagc atggctacca
    47821 ttaccaatca agtcactatc aaaatcagca acgacatttc cttcgttcat gacaccgata
    47881 gcccagtcaa tacttgcatc gttgcctaat ttaccacgac ggctaatgta ggcagtgacg
    47941 ttttcaccta gacggtcgat agcagcaaac ttgacttgcg caccagaacg tgcaatcact
    48001 tccactgtga tattggcagt tactttgtca cttccttcac cgcgtgactc taaacgctcc
    48061 agataactaa tcttagaatt tttaccagcg ataatcataa tatgcttgtt aaacggcaca
    48121 ttgctatcgc tatcttggta gaaaattcct tcaattggct ctgtgatttc tacgttatct
    48181 ggaatataga gtacagcacc actgttaaag taagctgtgt ggtaagccgc caacttgtca
    48241 tcatcatact taacagatga catgaagaat tcttcgatca gctctggaat ttcttctaaa
    48301 gctgagtgaa agtctgtgaa gacaacaccc tgttcagcta actcaactgg agtttgttcg
    48361 aaaacagttt gagttcctac ttgcaccaac ttcaagtgat gatctaaagc tgtgaaatct
    48421 ggaacatttg ctgatggctc attttctgta atcgttccat cacccagatt ccaacggtgg
    48481 aatttgacac gctcaataac tggtaattcc aaagtctcaa tcttgtcaaa agctttttga
    48541 cggagatcag ccaaccagct tggttcagcg tgcatttctg aaaaaagttt aatattttct
    48601 ctagtcattt acttctccta aaagatacga ggaaattaca attcttcctt gtagtcgtag
    48661 ccaagttctt cagctaattt tgcgtatcct tcacgttcca aacgcgcagc caattctgga
    48721 ccaccagaaa ggacaacacg accttccatc atcacgtgta ccacatcagg tgtgatatag
    48781 ttcaaaagac gttggtagtg agtgatgatc atagcaccaa aaccttcacc acgcatggca
    48841 ttgacacctt tagacacaac tttaagagcg tcaatatcaa gacctgagtc aatctcgtcc
    48901 aaaagagcaa atgttggctc caacatcaaa agttgaagaa tttcattgcg ttttttctca
    48961 ccaccagaga agccttcgtt gaggtaacgc tctgccattt cttctttcat gttgagcaat
    49021 tccatttttt catctagctt agtaataaac tcacgaactg aaatcttctc atcatcttct
    49081 ttacccgcat tcatagcggc acgaagaaac tcagcattgg taattccagg gatttctgat
    49141 gggtattgca tagcaaggaa aagtcccata cgcgcacgct catccacttc caactcaagg
    49201 atgtttacgc catcaaacaa aacttcacct ttagttactt catagtttgg atttcccatg
    49261 atagcggcag aaagagtcga tttacctgta ccatttggtc ccatgatagc ggcaatttct
    49321 cctgttttca gggtcaggtt aacccctttt aaaatttctt ttccttcaat ctcaacgtga
    49381 agatctttga tctctaatac tgacatgata gttcctttct ttttcaaaac ttttacagta
    49441 cttactagaa aaacgtctga tttccccaga aatagagcaa aaattctata aatatacttt
    49501 tctagtataa caaaaaaaag cctaaaaggc tttgattttg tctggaagct gagggctagt
    49561 ctttcctatt aaaatgctga tcgatgacat caacgatttt gcccatcaca taactgactc
    49621 ggaaatttct aaagagtaaa attgcccaaa aggctgccat aatatagcgg ccagtcatcc
    49681 aggcttcatt gaaaaaatag gtctcagcag ctgtaaacag cgccataata ataaattgtt
    49741 gtttattcat aaacttattg tatcatgaaa tctttcttta gtcttcctct accttcactt
    49801 tatcagccaa aaattcaaat ccttctggaa tcaggctttc ttctacttcc ttttcagttt
    49861 gagaagattt ggctttggct gaaaaggctg cgcgaacttc tttccattcc tccatggaaa
    49921 tagctaaaat ctcaggtgaa aaacctgccg cctgactgag gatattacca aacatggtat
    49981 tgagattgtc tcgtttcata gtttgaccag cattgaagtt agactcaaaa gcaagaatag
    50041 catggtgttc attggcagca accggttgag aaccaactag cagagccttg tccggcccac
    50101 ctagactttc aattacctct ccccaggcat tctgcaaacg aattagattt tgacgtgcta
    50161 aatcaggatt ttcgacggcc tcttgtaaga tagattgcac tttattgcga tcgacacgat
    50221 agactgtttt gcccgtagct ggtcgactag gagctggtgc aacttgttta ggaaccgcac
    50281 ctacattaga aagctcttgt ttgagacggg caacttcctg tctcagcgta gcaatttcat
    50341 tttcaaccgc tcctgataga gctggttcgg gcttgatttc cgccaaacgg acggtcatca
    50401 tttcagcata aatcttgggc tgcaaactag acttaatatc tgctaaactc actgttgcta
    50461 agcgaatcat ttcaaacaga tttttttgag gaagtgccaa attttctaca aagactgaac
    50521 tatgatgagt attttctccc cctgtttgaa caattaacaa gtctcttaaa tagtgcaaaa
    50581 gatcggtcac aaaacgagtc atgctcttac cattgtcaaa aagaagattc aagcaagaca
    50641 aagctttggg aacatcctgt tgagacaagg ccgccacata atcatccaag gctgataggc
    50701 taatggtgcc agtaatttct tcagagatag cagtcgtcag ctcatttccc tgtgtcaaac
    50761 tcagggcttg atccaaaata gacaaggcgt cccgcattcc accttccgcc cgtctggcaa
    50821 tgatttccac agcctctggt tcagaactga tattttcttt ttctaagata tagtgaatat
    50881 gttccttaat atcctgtgtc ttaattgatt taaactcaaa acgttgcaca cgggatagaa
    50941 tagtagcagg aatcttgtgc aattcagtag tggccaaaat aaagactaca ttctgtgttg
    51001 gttcttccag cgtctttagg agggcattaa aagcccctgt agacagcatg tgaacctcat
    51061 ctatgatata aaccttataa cgagcaaggc taggcgcata ggtagattta tcacgaattt
    51121 cgcgaatttc atctacccca ttattagaag ctgcatccat ttcaatgaca tcttctaaac
    51181 taccgtccgt cactgcttga caaatatagc agttattgca aggttcgcca cccacttgat
    51241 tgggacagtt catagccttg gcaaagattt tagcaacact ggtttttccc gttccacgag
    51301 gaccagaaaa aagataagcg tgacttattt tctcttgctc caccgcttgt ttaagagtct
    51361 tagccacaac ttcttgacca actaactggg agaagttttg acttctatat tttcgataaa
    51421 gtgcttgata cattaagatt tttcctcaaa catcgtaaag tcccatgttg tcttttcaag
    51481 caaaatagcg acaaattgtt ccaaataatc tcgatccata gcatcgtaat cctcaatctc
    51541 tgaagaatcc agatccagaa ctccaagtaa ctgaccattc ttcatcatcg gcaccacaat
    51601 ttcactttta gctagactat cacaagaaat atagttgaga taggtcgtca catctccaac
    51661 aataacagtt tcctgaaagt gagctgcctc accacaaaca cccttgccta gtgcaatacg
    51721 gatgcaggaa acacctcctt ggaaggggcc taaaaccaat tcctttccat cgaacaaata
    51781 aaagcctgca aatacggtat taggaaaacg tgattttatg agagcactgg cgttggaaag
    51841 attagccaaa acattggttt cgccttccaa taggaaggac aattcttcat ttaacatttg
    51901 ataacgtgat tgtttttctg attttaacat agaactatta tatcaaaaaa ggagcagaga
    51961 caaaagaaaa atcccttgtt tagtaaacaa aggattttgg gctctataat atttgtagtg
    52021 ggtaaatccc ctatggatat tatggagcct attttgtgta gaaaaaaagt cccatatgac
    52081 ctataatgaa aagcgaccaa acaactcatt agaaagattc atatggaaca attacatttt
    52141 atcacaaaat tactagacat ta
//
LOCUS       DAVHSO010000007        46570 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.007, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000007 DAVHSO010000000
VERSION     DAVHSO010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 46570)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46570)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46570
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.007"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(179..1021)
                     /locus_tag="VVR18_000400"
     CDS             complement(179..1021)
                     /locus_tag="VVR18_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001065636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6031991.1"
                     /translation="MNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNV
                     SAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYAYSRYN
                     FLARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHNWFLIFLYVGGGIPMNAWLM
                     KGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAFMGPFGDYILSSF
                     LLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFFLQKNFVSGLTSG
                     GDKG"
     gene            complement(1023..2315)
                     /locus_tag="VVR18_000401"
     CDS             complement(1023..2315)
                     /locus_tag="VVR18_000401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000414940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6031992.1"
                     /translation="MEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFL
                     ALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRIN
                     NGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLP
                     PNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQP
                     FIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALI
                     PWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNI
                     TFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTG
                     TSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV"
     gene            complement(2426..3697)
                     /locus_tag="VVR18_000402"
     CDS             complement(2426..3697)
                     /locus_tag="VVR18_000402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000095461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU6031993.1"
                     /translation="MSSKFMKSTAVLGTVTLASLLLVACGSKTADKSADSGSSEVKEL
                     TVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPY
                     DRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVK
                     DAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYTYGLLAGNGAYVFGQNGKD
                     AKDIGLANDGSIVGINYAKSWYEKWPKGMQDTEGAGNLIQTQFQEGKTAAIIDGPWKA
                     QAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEASQKFVDFLVATEQQ
                     KVLYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKNTQPLPNISQMSAVWDPAKNML
                     FDAVSGQKDAKTAANDAVTLIKETIKQKFGE"
     gene            4247..5764
                     /gene="malQ"
                     /locus_tag="VVR18_000403"
     CDS             4247..5764
                     /gene="malQ"
                     /locus_tag="VVR18_000403"
                     /EC_number="2.4.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-alpha-glucanotransferase"
                     /protein_id="HEU6031994.1"
                     /translation="MKKRQSGVLMHISSLPGAYGIGSFGQSAYDFVDFLVRTKQRYWQ
                     ILPLGATSYGDSPYQSFSAFAGNTHFIDLDILVEQGLLEASDLEGVDFGSDASEVDYA
                     KIYYARRPLLEKAVKRFFEVGDVKDFEKFAQDNQSWLELFAEYMAIKEYFDNLAWTEW
                     PDADARARKASALESYREQLADKLVYHRVTQYFFFQQWLKLKAYANDNHIEIVGDMPI
                     YVAEDSSDMWANPHLFKTDVNGKATCIAGCPPDEFSVTGQLWGNPIYDWEAMDKDGYK
                     WWIERLRESFKIYDIVRIDHFRGFESYWEIPAGSDTAAPGEWVKGPGYKLFAAVKEEL
                     GELNIIAEDLGFMTDEVIELRERTGFPGMKILQFAFNPEDESIDSPHLAPANSVMYTG
                     THDNNTVLGWYRNEIDDATREYMARYTNRKEYETVVHAMLRTVFSSVSFMAIATMQDL
                     LELDEAARMNFPSTLGGNWSWRMTEDQLTPAVEEGLLDLTTIYRRINENLVDLKK"
     gene            5790..8048
                     /gene="glgP"
                     /locus_tag="VVR18_000404"
     CDS             5790..8048
                     /gene="glgP"
                     /locus_tag="VVR18_000404"
                     /EC_number="2.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan family
                     phosphorylase"
                     /protein_id="HEU6031995.1"
                     /translation="MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTG
                     KKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGL
                     GRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSR
                     SYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARN
                     LTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDT
                     HPSMVIPELIRLLTARGIELDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHL
                     VPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSEL
                     KAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYED
                     KAAVKEKLESIKAHNKRKLARHLKEHQGVEINPNSIFDIQIKRLHEYKRQQMNALYVI
                     HKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVV
                     MVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAE
                     LVGDENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERL
                     ERLYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRT
                     IAQYNEDIWHLN"
     gene            complement(9093..9665)
                     /locus_tag="VVR18_000405"
     CDS             complement(9093..9665)
                     /locus_tag="VVR18_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031996.1"
                     /translation="MNKLMKFISVFLTSIVLIVSAIPSVSAVYASEQVSQIETNMELQ
                     PVTSLTEEQINTLANEIQSFHPDVSQQWIKEVINRQLQGDYTIPPTYSPFRAAWQGIT
                     VNQMGALLDTAIALALGGTTAGLANLIKVKGKHAAKSAIRSAISRYLGSWFVNDVALE
                     FAMNLLSPGTYLAQLWDKNDAIPNNGRINF"
     gene            complement(10266..11114)
                     /locus_tag="VVR18_000406"
     CDS             complement(10266..11114)
                     /locus_tag="VVR18_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEU6031997.1"
                     /translation="MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDL
                     AKFGYVNLAPQIKQSANYDKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDI
                     GCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDAN
                     MDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIK
                     EHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEI
                     LVGKAF"
     gene            11266..11544
                     /locus_tag="VVR18_000407"
     CDS             11266..11544
                     /locus_tag="VVR18_000407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003075836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6031998.1"
                     /translation="MLKEVLTVAKVAKKSSLFLGGVAFGTLGLKILASKEAKKGYSKA
                     LAKAYKLKDELDASVSVVKQHGDDVLQDAKYLYEQEKKEEQLDSLIGE"
     gene            11546..13609
                     /locus_tag="VVR18_000408"
     CDS             11546..13609
                     /locus_tag="VVR18_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HEU6031999.1"
                     /translation="MSFKVLHRGYQHIRLSSSFSLTLDIQDYLRSLARDEKGIESIQF
                     YMDQQHFTLRIKEGFSVLDNAEAFLKRIDKGKVSELMTLPIRREESAYSIVSGAAVKR
                     VLFRSFVPYPIRYIWTCYQALGYIREAYQTLARKELTMEVLDCSAILLSLFMNQSKTA
                     SNIMFMLDLGNHLDQWSLKKTATDLEQSLLAKESDVFLVQGDTVVSIKSSDVQIGDVL
                     ILSQGNEILFDGQVVSGLGMVNESSLTGESFPVEKRESDLVCANTVLETGELRIRVTD
                     NQMNSRILQLIELMKKSEENKKTKQRYFIKMADKVVKYNFLGAGLTYLLTGSFSKAIS
                     FLLVDFSCALKISTPVAYLTVIKEGLNREMVIKDGDVLEKYLEVDTFLFDKTGTITTS
                     YPIVEKVLPFGDYSEEDILRISACLEEHIYHPIANAIVKQAEIEGIEHEEMHGKLQYI
                     ASKGIKSHIDGQPVLIGNYVLMQDEQIHISSEQNALIEEYKSHYNLLFLAYQNELIGM
                     FCIHTPLRKEAKTALDKLKAQGKKLILATGDTLIRTEELVKDLPFDQVYTDLKPDGKF
                     ELVEKLQKAGHTILMVGDGLNDSAALTLSDIGVVMNESADISKQMSDILLLDNRLDFF
                     QELDSLSSSLQTLIKKNIQDTVVVNSSLIGFGLFNWFSPSNLSILHNLTTLRIVLRSL
                     SIKNR"
     gene            complement(13687..14943)
                     /locus_tag="VVR18_000409"
     CDS             complement(13687..14943)
                     /locus_tag="VVR18_000409"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HEU6032000.1"
                     /translation="MHIFDELKERGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSL
                     HLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQ
                     GQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIET
                     GISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVIT
                     VPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAVRFLKIFTFLSLDE
                     IEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKEL
                     KQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQDLDYV
                     LSDADKLENELTVIRRGKKKYFVLTY"
     gene            15085..17550
                     /locus_tag="VVR18_000410"
     CDS             15085..17550
                     /locus_tag="VVR18_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEU6032001.1"
                     /translation="MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKS
                     AIFPAILLSIKALFNLLFVLGFLGGMLGVGIALGYGVALFDKVRVPQTEELVNQVKDI
                     SSISEITYSDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV
                     IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEI
                     LTTYLNVAPFGRNNKGQNIAGARQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPY
                     ENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGI
                     SRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITT
                     TIDQKIHSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNH
                     AFDTKRSPASTTKPLLAYGIAIDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMT
                     LGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQ
                     HTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPIQVYSKATATIMQGLLREVL
                     SSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNH
                     SLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDPSVVKSEVLKSTGQKPGKVS
                     VEGKEVEVTGSTVTSYWANKSGASATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSS
                     SSSSSSDSSNSSTTRPSSSRARR"
     gene            17615..18526
                     /locus_tag="VVR18_000411"
     CDS             17615..18526
                     /locus_tag="VVR18_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HEU6032002.1"
                     /translation="MNQYQKKIVNGKIYSLLSGLIWGICGILGEYFFTHYQVSSGWIT
                     SMRLTLAGSIVLIWSAIQLKSQVLDIWRDKKNYLPFLAYAILGIFSVQYFFYLCVEYS
                     NATTATILQFISPVFILFYNRLVYQKRASKSAVFYVLVAMLGVCLMATKGDLSQLSMT
                     PLALITGLLSAMGVMFNVILPQPFAKRYGFVPTVGWGMILAGLFSNVLSPVYQLSFTL
                     DIWSILICLIIAFFGTAFAFFISMKAVSLVSPLVVAVISASEPLSSALLSVLFLGLVV
                     DWSLLLAIVLIILPMIFLSIEEAKESR"
     gene            18756..19454
                     /gene="dapD"
                     /locus_tag="VVR18_000412"
     CDS             18756..19454
                     /gene="dapD"
                     /locus_tag="VVR18_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HEU6032003.1"
                     /translation="MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLG
                     NVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEI
                     GDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAE
                     PVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQ
                     TQQKTALEDALRTL"
     gene            19522..20652
                     /locus_tag="VVR18_000413"
     CDS             19522..20652
                     /locus_tag="VVR18_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HEU6032004.1"
                     /translation="MLDLIQTRRALHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQI
                     RTWRTGILAYLQGSQPERTIGWRTDIDGLPIVEQTGLPFTSQHQGRMHACGHDFHMTI
                     ALGCLERALEEQPKNNLLFLFQPAEENEAGGMLMYEDGAFGDWLPDQFYGLHVRPDLK
                     VGQIATNTHTLFAGTCEVKIRFKGKGGHAAFPHEANDALVAASYFVTQVQSVVSRNVN
                     PIEGAVVTFGVFQAGTTNNVITDTAFLHGTIRALTQDMSLLVQKRVKTVAEGVAAAFD
                     MEVEVELKQGGYLPVENNPALARELMDFFDEKDGIELIDIEPAMTGEDFGYLLSKVDG
                     VMFWLGIDSPYALHHPQMSPKEEVLAIGVAAVSSFLKKKAAE"
     gene            20664..21203
                     /locus_tag="VVR18_000414"
     CDS             20664..21203
                     /locus_tag="VVR18_000414"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HEU6032005.1"
                     /translation="MKSELRKQVLHEMKAISQEQKQAIDQALTERILQHPFYQEAKVI
                     ATYLSFSHEFQTRELIEQALKDGKKVLTPKTYPKGRMDFVVYDPQQLVKTSFGLLEPQ
                     GDLEVVDVSKIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRALSTIYPCQIQDF
                     IPENHDIPVQEVLIDEGNL"
     gene            21187..21864
                     /locus_tag="VVR18_000415"
     CDS             21187..21864
                     /locus_tag="VVR18_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HEU6032006.1"
                     /translation="MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFG
                     AMYGSAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYL
                     LSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVV
                     NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILL
                     FYKGMGM"
     gene            complement(21936..22835)
                     /gene="galU"
                     /locus_tag="VVR18_000416"
     CDS             complement(21936..22835)
                     /gene="galU"
                     /locus_tag="VVR18_000416"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HEU6032007.1"
                     /translation="MTSKVRKAVIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVE
                     EALKSGIEDILVVTGKSKRSIEDHFDSNFELEYNLKEKGKTDLLKLVDKTTDMRLHFI
                     RQTHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITDEKAVPLTKQLMDDYERTHAST
                     IAVMPVPHDEVSAYGVIAPQGEGKNGLYSVETFVEKPAPEDAPSDLAIIGRYLLTPEI
                     FQILENQAPGAGNEIQLTDAIDTLNKTQRVFAREFNGARYDVGDKFGFMKTSIDYALK
                     HPQVKDDLKNYLIQLGKELTEKE"
     gene            complement(22857..23873)
                     /locus_tag="VVR18_000417"
     CDS             complement(22857..23873)
                     /locus_tag="VVR18_000417"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000415108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HEU6032008.1"
                     /translation="MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINT
                     HHTNKHYFKDVVLDENIIAYTDLAETLKDVDAILFVVPTKVTRLVAQQVAQTLDHKVI
                     IMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKD
                     LQTAQYVQKLFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAII
                     ARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIE
                     ANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAE
                     NEWS"
     gene            24085..24466
                     /locus_tag="VVR18_000418"
                     /pseudo
     CDS             24085..24466
                     /locus_tag="VVR18_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809823.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
     gene            complement(24640..25065)
                     /locus_tag="VVR18_000419"
     CDS             complement(24640..25065)
                     /locus_tag="VVR18_000419"
                     /inference="COORDINATES: protein motif:HMM:NF025080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6032009.1"
                     /translation="MTNLSSVDSEELFQFYRERGNAENFIKERKAGFFGDKTDSSTMI
                     KNEVRMMMGCLAYNLYLFLKQLAGDEVKALTIKRFRRLFLHIAGKYVSTARRHILKFS
                     SLYAYSKQFQALFDTICQINLILPVPYKARGQGKTCLTE"
     gene            complement(25133..25783)
                     /gene="phoU"
                     /locus_tag="VVR18_000420"
     CDS             complement(25133..25783)
                     /gene="phoU"
                     /locus_tag="VVR18_000420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEU6032010.1"
                     /translation="MRNQFDLELHELEQSFLGLGQLVLETASKALLALASKDKEMAEL
                     IINKDHAINQGQSAIELTCARLLALQQPQVSDLRFVISIMSSCSDLERMGDHMAGIAK
                     AVLQLKENQLAPDEEQLHQMGKLSLSMLADLLVAFPLHQASKAISIAQKDEQIDQYYY
                     ALSKEIIGLMKDQETSIPNGTQYLYIIGHLERFADYIANICERLVYLETGELVDLN"
     gene            complement(25798..26550)
                     /gene="pstB"
                     /locus_tag="VVR18_000421"
     CDS             complement(25798..26550)
                     /gene="pstB"
                     /locus_tag="VVR18_000421"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEU6032011.1"
                     /translation="MGTFSVRHLDLFYGDFQALKNISIQLPERQITALIGPSGCGKST
                     FLKTLNRMNDLVPSCHIEGQVLLDEQDIYSSKFNLNQLRKRVGMVFQQPNPFAMSIYD
                     NVAYGPRTHGIRDKKQLDALVEKSLKGAAIWDEVKDNLKKSAMSLSGGQQQRLCIARA
                     LAVEPDVLLMDEPTSALDPISTLKIEDLIQQLKKDYTIIIVTHNMQQASRISDKTAFF
                     LTGEICEFGDTVDVFTNPKDQRTEDYISGRFG"
     gene            complement(26552..27367)
                     /gene="pstA"
                     /locus_tag="VVR18_000422"
     CDS             complement(26552..27367)
                     /gene="pstA"
                     /locus_tag="VVR18_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEU6032012.1"
                     /translation="MSKYLLKLLVYCFSALTFGSLFLIIGFILIKGLPHLSLSLFSWT
                     YTSENISLMPAIISTVILVFGALLLALPIGIFAGFYLVEYTKKDSLCVKIMRLASDTL
                     SGIPSIVFGLFGMLFFVVFLGFQYSLLSGILTSVIMVLPVIIRSTEEALLSVSDSMRQ
                     ASYGLGAGKLRTVFRIVLPVAMPGILAGVILAIGRIVGETAALMYTLGTSTNTPSSLM
                     SSGRSLALHMYMLSSEGLHVNEAYATGVILIITVLMINTLSSLLSRKLVKGAS"
     gene            complement(27360..28223)
                     /gene="pstC"
                     /locus_tag="VVR18_000423"
     CDS             complement(27360..28223)
                     /gene="pstC"
                     /locus_tag="VVR18_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEU6032013.1"
                     /translation="MTKQAFKEAVFRAIFFMSATVAVVAILLICFFIFSNGLPFMANY
                     GFARFLLGSDWSPTNIPASYGILPMIVGSLLITLGAIVIGVPTGILTSVFMVYYCPKP
                     VYGFLKSAINLMAAIPSIVYGFFGLQLLVPWIRTFLGNGMSVLTASLLLGIMILPTII
                     SLSESAIRTVPKTYYSGSLALGASHERSIFSVILPAARSGILSAVILGIGRAVGETMA
                     VILVAGNQPIIPSGLFSGTRTLTTNIVLEMAYASGQHREALIATSAVLFFLILLINAY
                     FAYLKGKSSYE"
     gene            complement(28341..29216)
                     /locus_tag="VVR18_000424"
     CDS             complement(28341..29216)
                     /locus_tag="VVR18_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate-binding protein"
                     /protein_id="HEU6032014.1"
                     /translation="MKFKKMLTLAAIGLSGFGLVACGNQSAASKQSASGTIEVISREN
                     GSGTRGAFTEITGILKKDGDKKIDNTAKTAVIQNSTEGVLSAVQGNANAIGYISLGSL
                     TKSVKALEIDGVKASRDTVLDGEYPLQRPFNIVWSSNLSKLGQDFISFIHSKQGQQVV
                     TDNKFIEAKTETTEYTSQHLSGKLSVVGSTSVSSLMEKLAEAYKKENPEVTIDITSNG
                     SSAGITAVKEKTADIGMVSRELTPEEGKSLTHDAIALDGIAVVVNNDNKASQVSMAEL
                     ADVFSGKLTTWDKIK"
     gene            complement(29383..30714)
                     /locus_tag="VVR18_000425"
     CDS             complement(29383..30714)
                     /locus_tag="VVR18_000425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor histidine kinase"
                     /protein_id="HEU6032015.1"
                     /translation="MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGLGG
                     YWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLKSLAQYVSALKTKVSQQDQQYKD
                     LAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
                     HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLN
                     LAFVSNASHELRTPVTSIKGFAETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLL
                     TLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQ
                     ILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNK
                     GRSRQTGGTGLGLAIVKELSQLLSGQVTVTSQLGRGSCFTIFLPNQSFAQD"
     gene            complement(30715..31422)
                     /locus_tag="VVR18_000426"
     CDS             complement(30715..31422)
                     /locus_tag="VVR18_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032016.1"
                     /translation="MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAET
                     EPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLT
                     KPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
                     LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKA
                     PQFIRTIRGYGYKFKEL"
     gene            complement(31506..31808)
                     /locus_tag="VVR18_000427"
     CDS             complement(31506..31808)
                     /locus_tag="VVR18_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEU6032017.1"
                     /translation="MTADEIWYFHAESPLTVHMITADGHYEAVTLGLDISKGQQLHYC
                     VPKGTIWGSTVDKDDALVSCLVAPGFEFEDFELFERVDLLATYPEHKEMIERLTRY"
     gene            complement(31795..32016)
                     /locus_tag="VVR18_000428"
     CDS             complement(31795..32016)
                     /locus_tag="VVR18_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEU6032018.1"
                     /translation="MNKSYFNPLAPTDKEDLIRTLELAPHVEGGYFRQTKKASDTINL
                     AGKGRALYTSIYFLLRRNESFTFSPIDSR"
     gene            31978..32535
                     /locus_tag="VVR18_000429"
                     /pseudo
     CDS             31978..32535
                     /locus_tag="VVR18_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(32850..34541)
                     /locus_tag="VVR18_000430"
     CDS             complement(32850..34541)
                     /locus_tag="VVR18_000430"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HEU6032019.1"
                     /translation="MNTKELIASELASIIDSLDQEAILKLLETPKNSEMGDIAFPAFS
                     LAKVERKAPQMIAAELAEKMNSQAFEKVVATGPYVNFFLDKSAISAQVLQAVTTEKEH
                     YADQNIGKQENVVIDMSSPNIAKPFSIGHLRSTVIGDSLSHIFQKIGYQTVKVNHLGD
                     WGKQFGMLIVAYKKWGDEEAVKAHPIDELLKLYVRINAEAENDPSLDEEAREWFRKLE
                     NGDEEALALWQWFRDESLVEFNRLYNELKVEFDSYNGEAFYNDKMDAVVDILSEKGLL
                     LESEGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKNEYQFAKSIYVVGQE
                     QSAHFKQLKAVLQEMGYDWSDDITHVPFGLVTKEGKKLSTRKGNVILLEPTVAEAVSR
                     AKVQIEAKNPELENKDQVAHAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYV
                     QYAYARIQSILRKADFKPETAGNYSLNDTESWEIIKLIQDFPRIINRAADNFEPSIIA
                     KFAISLAQSFNKYYAHTRILDESPERDSRLALSYATAVVLKEALRLLGVEAPEKM"
     gene            34677..35123
                     /gene="argR"
                     /locus_tag="VVR18_000431"
     CDS             34677..35123
                     /gene="argR"
                     /locus_tag="VVR18_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEU6032020.1"
                     /translation="MRKRDRHQLIKKMITEEKLSTQKEIQDRLEAHNVCVTQTTLSRD
                     LREIGLTKVKKNDMVYYVLVNETEKIDLVEFLSHHLEGVARAEFTLVLHTKLGEASVL
                     ANIVDVNKDEWILGTVAGANTLLVICRDQHVAKLMEDRLLDLMKDK"
     gene            35174..37708
                     /gene="mutS"
                     /locus_tag="VVR18_000432"
     CDS             35174..37708
                     /gene="mutS"
                     /locus_tag="VVR18_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HEU6032021.1"
                     /translation="MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAA
                     QILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVV
                     KREVVQVITPGTVVDSSKPDSQNNFLVAIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
                     VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQT
                     ASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLF
                     WLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYD
                     IERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELES
                     LISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTL
                     KIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSA
                     NLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQID
                     IRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQL
                     GSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDE
                     LGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQ
                     DGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQT
                     SAVTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL"
     gene            37855..39549
                     /gene="patA"
                     /locus_tag="VVR18_000433"
     CDS             37855..39549
                     /gene="patA"
                     /locus_tag="VVR18_000433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatA"
                     /protein_id="HEU6032022.1"
                     /translation="MLIQKIKTYKWQALASLLMTGLMVASSLLQPRYLQEVLGALLTG
                     KYEVIYSIGTWLIGVAVVGLVAGGLNVVLAAYIAQGVSSDLREDAFRKIQTFSYADIE
                     QFNAGNLVVRMTNDINQIQNVVMMTFQILFRLPLLFIGSFILALQTLPSLWWVIVLMV
                     VLIFGLTAVMMGMMGPRFAKFQTLLERINAIAKENLRGVRVVKSFVQEKEQFAKFTEV
                     SDELLGQNLYIGYAFSVVEPFMMLVGYGAVFLSIWLVAGMVQSDPSVVGSIASFVNYL
                     SQIIFTIVMVGFLGNSVSRAMISMRRIREILDAEPAMTFKDIPDEELVGSLSFENVTF
                     TYPMDKEPMLKDVSFTIEPGQMVGVVGATGAGKSTLAQLIPRLFDPQDGAIKIGGKDI
                     REVSEGTLRKTVSIVLQRAILFSGTIADNLRQGKGNATLFEMERAANIAQASEFIHRM
                     EKTFESPVEERGTNFSGGQKQRMSIARGIVSNPRILIFDDSTSALDAKSERLVQEALN
                     KDLKGTTTIIIAQKISSVVHADKILVLNQGRLIGQGTHADLVANNAVYREIYETQK"
     gene            complement(39879..40142)
                     /locus_tag="VVR18_000434"
                     /pseudo
     CDS             complement(39879..40142)
                     /locus_tag="VVR18_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199219.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            40340..42106
                     /gene="patB"
                     /locus_tag="VVR18_000435"
     CDS             40340..42106
                     /gene="patB"
                     /locus_tag="VVR18_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatB"
                     /protein_id="HEU6032023.1"
                     /translation="MKTVQFFWHYFKVYKFSFVVVILMIVLATFAQALFPVFSGQAVT
                     QLANLVQAYQNGNPELVWQSLSGIMVNLGLLVLVLFISSVIYMCLMTRVIAESTNEMR
                     KGLFGKLAQLTVSFFDRRQDGDILSHFTSDLDNILQAFNESLIQVMSNIVLYIGLILV
                     MFSRNVTLALITIASTPLAFLMLIFIVKMARKYTNLQQKEVGKLNAYMDESISGQKAV
                     IVQGIQEDMMAGFLEQNERVRKATFKGRMFSGILFPVMNGMSLINTAIVIFAGSAVLL
                     NDKSIETSTALGLIVMFAQFSQQYYQPIIQVAASWGSLQLAFTGAERIQEMFDAEEEI
                     RPEKAPTFTKLQESVEISHIDFSYLPDKPILKDVSISAPKGQMTAVVGPTGSGKTTIM
                     NLINRFYDVDAGGIYFDGKDIRGYDLDSLRSKVGIVLQDSVLFSGTIRDNIRFGVPDA
                     NQEMVEVAAKATHIHDYIESLPDKYDTLIDDDQSIFSTGQKQLISIARTLMTDPEVLI
                     LDEATSNVDTVTESKIQHAMEVVVAGRTSFVIAHRLKTILNADQIIVLKDGEVIERGN
                     HHELLKLGGFYSELYHNQFVFE"
     gene            42245..42934
                     /locus_tag="VVR18_000436"
     CDS             42245..42934
                     /locus_tag="VVR18_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEU6032024.1"
                     /translation="MARTVVGVAANLCPVDAEGKIIHSSVSCRFAEIIRQVGGLPLVI
                     PVGDESVVRDYVEMIDKLILTGGQNVHPQFYGEKKTVESDDYNLVRDEFELALLKEAL
                     RQNKPIMAICRGVQLVNVAFGGTLNQEIEGHWQGLPFGTSHSIETVEGSVVAKLFGKE
                     SQVNSVHRQSIKDLAPNFRVTAIDSRDQTIEAIESIDEHRIIGLQWHPEFLVNEEDGN
                     LELFEYLLNEL"
     gene            42938..43117
                     /locus_tag="VVR18_000437"
     CDS             42938..43117
                     /locus_tag="VVR18_000437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032025.1"
                     /translation="MEHLVVLSFIFSKFLECGILRKRLNSDKNWRNSTKKLEKNEGKR
                     YDRKEEILEEEHVTY"
     gene            43104..44453
                     /locus_tag="VVR18_000438"
     CDS             43104..44453
                     /locus_tag="VVR18_000438"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HEU6032026.1"
                     /translation="MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSD
                     FLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFAN
                     LQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFK
                     ELLIKKYGQEEANKRIYATTDRQKGAVKVEADANGWGTFVVPDDIGGRFSVLTAVGLL
                     PIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEP
                     SLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDK
                     PRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAF
                     TLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL"
     gene            44577..46037
                     /locus_tag="VVR18_000439"
     CDS             44577..46037
                     /locus_tag="VVR18_000439"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HEU6032027.1"
                     /translation="MSKDIRVRYAPSPTGLLHIGNARTALFNYLYARHHGGTFLIRIE
                     DTDRKRHVEDGERSQLENLRWLGMDWDESPESHENYRQSERLDLYQKYIDQLLAEGKA
                     YKSYVTEEELAAERERQEAAGETPRYINEYLGMSEEEKAAYIAEREAAGIIPTVRLAV
                     NESGIYKWHDMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVIDDHDMQISHVIRGD
                     DHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYL
                     PEAVFNFIALLGWNPGGEDEIFSREELIKLFDENRLSKSPAAFDQKKLDWMSNDYIKN
                     ADLETIFEMAKPFLEEAGRLTDKAEKLVELYKPQMKSVDEIIPLTDLFFSDFPELTEA
                     EREVMTGETVPTVLEAFKAKLEAMTDDEFVTENIFPQIKAVQKETGIKGKNLFMPIRI
                     AVSGEMHGPELPDTIFLLGREKSIQHIENILKEISK"
     gene            46051..46485
                     /locus_tag="VVR18_000440"
     CDS             46051..46485
                     /locus_tag="VVR18_000440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEU6032028.1"
                     /translation="MDIWEKMYEEAQKLYNPHEVSDFVYANHVVAAVEAGDGQIFTGF
                     CMEGTCGVFHLCAERAALFNMYQFSGQTKVKKVLAFRDKPPYGGSSAMPCGACREFLL
                     ELNAENKDAEFMMDYNIRKTVKVSELIPYWWGEERASKFNER"
BASE COUNT        13713 a         8860 c        10099 g        13898 t
ORIGIN      
        1 gaaaaattgc ttgctacaag gatattattt acagtgacaa ttgctaataa tcaatgaaaa
       61 tcaaagtgca aactagccac aggttgctca aagcacaact ttgaggttgg agataaagct
      121 gacgtggttt gaagagattt tcgaagagta taaaatgaaa aagggtggcg gggataaatt
      181 atcccttgtc gccaccactt gtaagtcctg aaacaaagtt cttttgtaga aagaagaaga
      241 gaatacagat tggaagggcg atgaggatag cacctgctga gaagtaggca atcttcaagt
      301 ttttcgcatt gttaacgaag gtttggagac ctacggcaac agtaaagtat tctttctcac
      361 gaagcaagaa actagagagg atgtagtccc cgaaaggtcc catgaaggcc cagagagctt
      421 gtacggcaac cattgggcga acaagtggta gaacaatttg ccagaagcgg cggaagtgtc
      481 ctgcaccgtc tagttttgca gattcgtcta aagacattgg cactgtatcg aagtagcctt
      541 tcatgagcca agcattcatc gggataccac caccaacgta gaggaagatg aggaaccagt
      601 tgtggttaag ggcgttcaac ataagcgcca taacgaagaa ggctgtcaaa gcggccatag
      661 ttggcaccat ttggatgatc aagaagaaga ccaaactttg tttacgagcc aagaagttgt
      721 aacggctgta agcataacca gcaagtacga tgatacttgt ttgaacagcc atggtaatta
      781 aggcgataat caaagtgttg aggtaccaag taccgtacaa ggtttcagtg aagaggcctt
      841 taaagttatc aaaattgagg tcgatattag tatctagttt aaaggctgag acgttacctg
      901 ctttaaaggc tgacataatg gtaatcaaca gtggatagat aattacaatt gatagaccaa
      961 tcaggtaaag gtaagtaagg ctttgagtca gtctacgttt gagtttaatt gagttattca
     1021 tcttagacgt cctccatatc aaatgcgtgt agtttcttga atgcgatcat agagattgag
     1081 atgacaatga tagagataat caaggtaaca gctgccgcca ttgagtattg aggagatgta
     1141 cctgttgtca aacggtagat ccatgagatc aagatatcgg ttgaaccagc tccacctccg
     1201 acactaccag gtcctccacc attgaagagg tacatgatag agaagttgtt aaagttgaag
     1261 gtgtattggc taatcaaagt aggtgccgca acagccaaaa tcattgggaa agtgatgttg
     1321 cggaattttt gccaagcgtt ggcaccgtca atataagctg cttcgtaaag gtcgttagga
     1381 atagattgca agatacccaa agtcaaaacg tagatgtatg ggaatccgag ccaaccttgc
     1441 atcataatca aggcaatctt agtccaagtt gggtctgttt tccaaggaat aagagctcca
     1501 tcaaggaaag gaaggaattt agccaagatt ggcaatactt gagtgttgat agcaccgaca
     1561 ctatcgttaa acatgtttga gaatgtcaag atagtgatga aggctgggac agcccaagga
     1621 agaaggaaaa taacaccaaa gatacgtttt cctttgataa atggttggtt ggcaatgata
     1681 gctgtgaaga taccaattac gatttgtaaa gtagaagctg ccaaagccca aatgatagtc
     1741 caagaaagaa cagaaccaaa ggcagaacgg aaggtactca agctccaaat gtttgtaaag
     1801 ttggtcaaac caacccagtc caacaacttg tttggtggca agtgttggaa gtcgtagttg
     1861 gtaaaggcga tcatcaaggt tacgataact gggaagataa tcgcgaaggt catggcaaca
     1921 taagatggaa tgatcaagag gtaagggaag ccattttcat aaatcccttt gatcatgtct
     1981 ttgagtgtgc gtggaactgg aattccattg ttaatgcgtt ttgcaatcgt atgtgcatct
     2041 ttgatatttg agaaataaaa gagtacataa acgattacaa agattagatg gaaggcacca
     2101 cgaatcagca taaagaggga attatcacga cctggtttgt caccaagagt gatgaggttg
     2161 ctcaattcag gggttgcaag tgctaggaag taaaggacaa atacgatggt tacaccaagg
     2221 aagataaaac ctttggcttt ttgtttattg taaatctgtc ctaacccagg aatgatagac
     2281 agcagggctg ctttactagg ttgttgcttt tccatattaa ctcctttcat aggatactac
     2341 ttttttataa gaaagctaaa ttatttgtgt ctctattgat aaattcaaag ggggatttga
     2401 tttccacccc ccttgaacaa attttttatt caccaaattt ttgtttgatt gtttctttga
     2461 tcaatgttac agcatcgtta gcagctgttt tagcatcttt ttgaccactt acagcatcaa
     2521 agagcatatt tttcgctgga tcccaaactg cagacatttg agagatgttt ggcagtggtt
     2581 gagtgttctt gaactgtttg ataacagctg ttgtcaactc atcgttttta ccttcagcgt
     2641 atgaacgagc ctcagtatta gctgggattt cgttagtctt atcatataat actttttgtt
     2701 gttcagttgc aacaaggaag tctacaaatt tttgagaagc ttcaaggttc ttaacggctt
     2761 gaggaatgac ccaagcttta ccaccaccga atgcagcata ttcttttcca tttggaagag
     2821 ttgggatagt tgcaactccg tagtttactt tagcatcttt aaaggcttga gctttccaag
     2881 gtccgtcgat gatagcagct gttttacctt cttggaattg agtttggatt aagtttccag
     2941 caccttctgt atcttgcata cctttaggcc atttttcgta ccaagattta gcgtagttga
     3001 tacctacgat agaaccgtcg tttgcaagac cgatgtcttt agcgtcttta ccgttttggc
     3061 caaagacgta agcaccgtta ccggcaagaa gtccatatgt atagtagaag tttgtccagt
     3121 cagctaggaa ggcagtagtt ttaccatctt caccagcgaa tgcgtatttg ctatctttag
     3181 caaggttttc caagtcagca aatgtttttg gagcatcttt caccaagtct ttgttgtagt
     3241 acataacaag tgactcgata acggcaggag caccgtaaac tttaccatta gcagctgtta
     3301 caagagattt agttgtgtcg tctgttttag caccatcgct caatttcact tctgaaagtt
     3361 gtccgtcaga accaaggcta cctacacggt cgtatggagc catcataaca tcagggacat
     3421 taccagattg gttgtcaaga gaaagtttat caagacctcc tagagcatca ccagttttaa
     3481 gagtgacttt tactccagct tctttttcat aagctttagc aacctcttca atatagctct
     3541 tatatccctc gtctacatat acagtgagtt ctttgacttc agatgaacca gaatcagcag
     3601 acttatcagc agttttgctt ccgcaagcta ccaaaagcaa gctagcaagt gtaacagttc
     3661 caagcaccgc agtgctcttc ataaatttag atgacatagt gtattcctcc caaagaatag
     3721 caagttttat tgataaggaa acgcaaacgt tttcctttat gagcttagta tagcacaaat
     3781 agaaaacggt tgcaagtatt ttttgtaaaa attttaaaaa atttttaagc ttgatttgat
     3841 agcataattt tgcattttaa tagaagaaaa gtatgaaata gataagaata cagtattttt
     3901 aataaaaata tatggaatct gtctaaagag ggaaaccagg aggggctacc tccctgtttc
     3961 taatccctat ctattttcta tagacgtttg tgctttgtta catataaatt caagctccct
     4021 aaggaggttt tgtactttgt agactgtctc gtgagagtca aactttagga ttagatagtt
     4081 ttaagttatc tttgctaaaa tgagttagtc tccttaaaaa taatcaaaaa agttttttaa
     4141 aaacgcttgc aattatgctt gaaaaggagt atacttataa gtaacgcaaa cgtttgcgtc
     4201 tgcaaaatac gcaacgttcc attattttaa cacacgaggt gctattatga aaaaacgtca
     4261 aagtggtgtg ttgatgcaca tctcttctct tccaggagct tacggaatcg gatcatttgg
     4321 tcaaagtgct tacgacttcg ttgatttctt ggtccgtaca aaacaacgtt actggcaaat
     4381 ccttccatta ggagcaacta gttacgggga ttctccttac caatctttct cagccttcgc
     4441 aggaaacact cattttatcg atttagatat cttggtggag caaggtttgt tggaagcaag
     4501 tgaccttgaa ggagttgact ttggtagcga tgcgtctgaa gttgactatg ctaaaatcta
     4561 ctatgcacgt cgtcctcttt tagaaaaagc ggtgaaacgt ttctttgaag tcggagatgt
     4621 taaagatttt gagaaatttg ctcaagacaa ccaatcatgg cttgagctct ttgctgagta
     4681 tatggctatc aaagagtatt ttgacaatct tgcttggact gaatggccag atgcagatgc
     4741 tcgtgctcgt aaagcttcag cacttgaaag ctatcgtgag caattggcag acaagttggt
     4801 ttaccaccgt gtgactcaat acttcttctt ccaacaatgg ttgaaattga aagcttacgc
     4861 taacgacaac cacatcgaaa tcgttgggga catgccaatc tacgtagcgg aagattcaag
     4921 tgatatgtgg gcaaatccac atctcttcaa aacagatgtc aatggtaagg ctacttgtat
     4981 cgcaggatgc ccaccagatg agttttctgt aactggtcag ctttggggta atccaatcta
     5041 tgactgggaa gcaatggaca aagacggcta caaatggtgg attgaacgct tgcgtgaaag
     5101 cttcaaaatc tacgatatcg ttcgtatcga ccacttccgt ggcttcgaat cttactggga
     5161 aatccctgct ggttccgata cagcagcacc tggtgagtgg gtgaaaggtc caggctacaa
     5221 gctttttgca gccgttaagg aagaacttgg tgagctaaac atcatcgcag aagaccttgg
     5281 cttcatgaca gatgaagtga tcgaattacg tgaacgtact ggcttcccag gaatgaagat
     5341 tcttcaattt gccttcaacc cagaagacga aagcattgat agcccacact tggcacctgc
     5401 taactcagtt atgtacacag gaacacacga taacaatacg gttcttggtt ggtaccgtaa
     5461 tgagattgat gatgcgactc gtgagtacat ggctcgttac acgaaccgta aagaatacga
     5521 aacagtggta cacgctatgc ttcgtacagt attttcatca gttagcttta tggcaattgc
     5581 aactatgcaa gatttactag aattggatga ggcagctcgt atgaacttcc catctaccct
     5641 tggtggaaac tggtcttggc gtatgactga agatcaattg acaccagctg tcgaggaagg
     5701 tttgcttgac ttgacaacaa tttatcgccg aattaatgaa aatttggtag atttaaagaa
     5761 ataagacaat aatcaggaga caactaaaca tgttatcact acaagaattt gtacaaaatc
     5821 gttacaataa aaccattgca gaatgtagca atgaagagct ttaccttgct cttcttaact
     5881 acagcaagct tgcaagcagc caaaaaccag tcaacactgg taagaaaaaa gtttactaca
     5941 tctcagctga gttcttgatt ggtaaactct tgtcaaacaa cttgattaac cttggtcttt
     6001 acgacgatgt taaaaaagaa cttgcagctg caggtaaaga cttgatcgaa gttgaagaag
     6061 ttgaattgga accatctctt ggtaatggtg gtttgggacg tttggctgcc tgctttatcg
     6121 actcaattgc tactcttggt ttgaatggtg acggtgttgg tcttaactac cactttggtc
     6181 ttttccaaca agttcttaaa aacaaccaac aagaaacaat tccaaatgca tggttgacag
     6241 agcaaaactg gttggttcgc tcaagccgta gctaccaagt accatttgca gactttactt
     6301 tgacatcaac tctttacgat attgatgtta ctggttatga aacagcgact aaaaaccgct
     6361 tgcgtttgtt tgacttggat tcagttgatt cttctattat taaagatggt atcaactttg
     6421 acaagacaga tatcgctcgc aacttgactc tcttccttta cccagatgat agtgaccgtc
     6481 aaggtgaatt gctccgtatc ttccaacaat atttcatggt ttcaaacggt gcgcaattga
     6541 tcatcgacga agcaatcgaa aaaggaagca acttgcatga ccttgctgac tacgcagttg
     6601 tccaaatcaa cgatactcac ccatcaatgg tgattcctga attgattcgt cttttgactg
     6661 cacgtggtat cgagcttgac gaagcaatct caattgttcg tagcatgact gcctacacta
     6721 accacacaat ccttgctgag gcgcttgaaa aatggcctct tgaattcttg caagaagtgg
     6781 ttcctcactt ggtaccaatc atcgaagaat tggaccgtcg tgtgaaggca gagtacaaag
     6841 atccagctgt tcaaatcatc gatgagagcg gacgtgttca catggctcac atggatatcc
     6901 actacggata cagtgttaac ggggttgcag cactccatac tgaaatcttg aaaaattctg
     6961 agttgaaagc cttctacgac ctttacccag aaaagttcaa caacaaaaca aacggtatca
     7021 ctttccgtcg ttggcttatg catgctaacc caagattgtc tcactacttg gatgagattc
     7081 ttggagatgg ttggcaccat gaagcagatg agcttgaaaa acttttgtct tatgaagaca
     7141 aagcagctgt caaagaaaaa ttggaaagca tcaaggctca caacaaacgt aaattggctc
     7201 gtcacttgaa agaacaccaa ggtgtggaaa tcaatccaaa ttctatcttt gatatccaaa
     7261 tcaaacgtct tcacgagtac aaacgccaac aaatgaacgc tttgtacgtg atccacaaat
     7321 accttgacat caaagctggt aacatccctg ctcgtccaat cacaatcttc tttggtggta
     7381 aagcagctcc agcctacaca atcgctcaag acattatcca tttaatcctt tgcatgtcag
     7441 aagttattgc taacgatcca gcagtagctc cacacttgca agtagttatg gttgaaaact
     7501 acaacgttac tgcagcaagt ttccttatcc cagcatgtga tatctcagaa caaatctcac
     7561 ttgcttctaa agaagcttca ggtactggta acatgaaatt catgttgaac ggagctttga
     7621 ctcttggtac tatggacgga gctaacgtgg aaatcgctga gttggttggt gacgaaaaca
     7681 tctacatctt tggtgaagat tcagaaactg ttatcgacct ttacgcaaaa gcagcatata
     7741 aatcaagcga attctacgct cgtgaagcta tcaaaccatt ggttgacttc atcgttagtg
     7801 atgcagttct tgcagctgga aacaaagagc gcttggaacg tctttacaat gaattgatca
     7861 acaaagactg gttcatgact cttcttgatt tggaagacta catcaaagtc aaagagcaaa
     7921 tgcttgctga ctacgaagac cgtgacgcat ggttggataa agtcatcgtt aacatttcta
     7981 aagcaggatt cttctcatct gaccgtacaa tcgctcagta taatgaagac atctggcact
     8041 tgaactaata ctcttcgaaa atctcttcaa accacgtcag ctttatctgc aacctcaaag
     8101 cggtgctttg agcaacctgc ggctagcttc ctagtttgct ctttgatttt cattgagtat
     8161 aagatacaaa tttatactaa tacattttgt aaaaaagtga gtttcgattg aaattcgctt
     8221 ttttaaatgc tgtggatttg ggtcaatctt gtctaaaaat agggaaatcc tagatacagt
     8281 gaaggcttta aatgctggtt tttactgtct tcagccttat attttttcgt agttggttac
     8341 ctcatatctc ttgtattcgc ttacataaag tattataata taattgtagg aaagaaggtg
     8401 tttttatgat atacacactt aaattggtgt tgtttattac ctttcttgta ataagcttgt
     8461 tacctgataa gatttttgga aaaaataaaa aaatttggaa aatagttttt gcaatattga
     8521 cggcagtggc agcattgtca tttatgtact aagttatttt aagaatgtag ggaaataaac
     8581 cctacattct ttttagtttt ttctgttttc taaattctat ttatccaagc gcttcaacat
     8641 ttcttgcttc ttcgcttcaa gttctgcacg cttttcttcg atttcggcat gttttttctc
     8701 gagttcagaa caacttgcac cattgctaaa ttcttttcgc catcaggaga tagggtgagt
     8761 cgacatgtct attactcacc caaagcagtc ctacaaagca ggaattttct gttacttttt
     8821 tggaaatagt aacgtttata cagctttggc acttcgtatc aaagcgccaa acacactccg
     8881 agggatttac agaaagcaga aaaggaatga tctggtataa gatcattcct tttctctctt
     8941 tttctttaag taattatata caatgtacga cgaagtcgtc attgcaatgc tgatccacca
     9001 cctaaaggga actttaaaca acattgataa gataaagaat ataaacaacg aaaatacgtt
     9061 atacccaatt aattttattg tatatctcat gattaaaagt taatccttcc gttgttagga
     9121 atggcatcat ttttatccca taattgtgct aaataagtcc ccggtgataa taaattcata
     9181 gcgaattcta aagcaacatc atttacaaac caactaccta gatatctaga aattgctgaa
     9241 cgaatagcac tttttgctgc atgttttcct tttactttaa ttagatttgc aaggcctgca
     9301 gtagttcctc ctaatgctaa agctattgca gtatctaata gagcacccat ttgattaact
     9361 gtaatacctt gccaagctgc tctaaatgga gagtatgtag gtgggattgt ataatcgcct
     9421 tgtaattgtc ggttaattac ttctttgatc cattgttgtg agacgtctgg atgaaaagat
     9481 tggatttcgt ttgcaagtgt attgatttgt tcttctgtta gagaagtgac aggttgaagt
     9541 tccatatttg tttcaatttg tgatacttgt tcagaagcgt atacagctga aacacttgga
     9601 atcgctgata caattaacac aattgacgtc aaaaaaaccg aaataaattt cattaatttg
     9661 ttcatgagct tttctccttt ttatttgtat ctgcttacat tttatcatat actgttatta
     9721 tagtcaaaaa aatatttttc aaaatataaa tggacggatt tattttggat tttatttgtt
     9781 attttgacct gcctctatat tggtaaccat gatttgttta ctctcaatca tcaagaattc
     9841 tcttttcgtg gtagcgtttg gggtctggta ctggccttat atcacttact attcattgat
     9901 aagtttgtta tatcgaatcg aaaataaaga ttagagctat gcttgactgt gtacttttag
     9961 gattgatttt ggaggaagat tttgtctcta ttatttatta ttttaaattt atttattttg
    10021 tataagatct attctttgag gcgggaaaaa tcgaaatact tgatttatac ggcctatatc
    10081 atatttgggg taaatgtagt atatggtatt caatggttat taaaagaact gatttcaact
    10141 atttcccctt aatgtgtatg gaaactataa caaaacgcat aagattaagg tttgtgtacc
    10201 tgttcttatg cgtttttata atattgaaga ttttcggtaa gttttatacc tttgggaagt
    10261 ctagtttaga atgctttccc aaccaaaatc tctgcttcga tggtaatctc tgtcagttgg
    10321 ctccagtcaa tcttgctctg gtcaacgtga aagaggagag gagtcatact gagtagggct
    10381 tggagttgtt ctgctgtgat agtcttagtc agagaggcag tttgactaga taggatggta
    10441 aagtgttcct ggaaatgctc cttgatatct tggttagaat actccttgtt tgtcagctgg
    10501 tcctgtactc tttgacggat ttctttgagg tgattttcag ttgggataac ctttatcaag
    10561 ataccgtctt tggataaaac gcgacgaaat tctccatagt tggcaggtga gaagatatca
    10621 agcagaatat ccatgttagc gtcttttata ggaaggcgtg ccaagtcgcc aacgaaccaa
    10681 ttgactgccc agttgggttc acttttagca gcgatttgga ctgaatcttt ggagatgtca
    10741 aaggcataga aagttttttc agagtgactt tcttgtagtt tgcgagaata gaatccttca
    10801 ccacaaccga tatccaaaat tgttgtggta gtttttgagc ttgcaagcaa gtcagataca
    10861 gcatctaaga tagcttggta aaagccggct tctaggattt gttgacggtt ttgaaaattt
    10921 tccttgtcat agttagcaga ttgcttgatt tgaggtgcta gattgacata gccaaatttc
    10981 gccaagtcaa aagaatgacg gttgcagcac ttgaaattag tttctaacag agtcagattt
    11041 tcttgacaga taggacaggc aaaggcagtc gcagaagcaa aacgctgaag tttgggtttg
    11101 agatttgtat tcatagttta agtgtatcaa aagaggcaaa tgaaagcaac tttaggaata
    11161 agtagatggg agattcagta gaaataaaac taattctcca atttatagaa tgaaattgct
    11221 tttatatcta aattgctata taataatgat aaggaggaaa taagtatgtt aaaagaagta
    11281 ttaaccgttg caaaagttgc gaaaaaatct tcattatttt tgggtggtgt cgcatttggt
    11341 acccttggtt tgaaaatctt agcaagtaag gaagctaaaa aaggttattc taaagctttg
    11401 gctaaggctt acaagttgaa agacgagcta gatgcatctg tttctgttgt gaagcaacat
    11461 ggagacgatg tcttgcaaga tgccaaatat ttgtacgagc aagagaaaaa agaagagcaa
    11521 ttagatagcc ttataggtga ataatatgtc ttttaaagtg ctacatagag gataccaaca
    11581 tatccgacta tcatcttctt tttcacttac cttggatatt caagactatc ttcgttcctt
    11641 ggcgagagat gaaaagggga ttgagtctat ccagttttac atggatcaac agcactttac
    11701 tctacgcata aaagaaggct tttctgtatt agataatgca gaagcctttt taaaaagaat
    11761 tgataaaggg aaagtttctg agttgatgac tcttcccatt cgtagagaag agagtgctta
    11821 ttctattgtt tcaggtgcag cggttaagcg tgtacttttt cgtagttttg tgccgtatcc
    11881 tattcgctat atatggactt gttatcaggc tttgggttat attagagaag cctatcaaac
    11941 actagcgcgt aaggaactaa cgatggaagt cttggactgt tcggctattt tattgtcctt
    12001 gtttatgaac caatccaaga cagctagcaa tatcatgttt atgcttgatt tggggaatca
    12061 tttagatcag tggtccttga aaaaaactgc aacagattta gaacagagtc ttcttgcaaa
    12121 agagagcgat gtattcctag tacagggcga tacggttgtt agtatcaaga gttccgatgt
    12181 tcaaatagga gatgtcttga tcttatctca aggaaatgaa attctgtttg atggacaagt
    12241 agtttcaggt ttaggtatgg tcaacgaaag ttccttgaca ggagagagtt ttccagttga
    12301 aaaaagagag tctgatttgg tttgtgcaaa tacagtatta gaaactggag agttacgcat
    12361 tcgtgtaaca gataatcaga tgaacagccg tattttacag ctgattgagt tgatgaagaa
    12421 atctgaagaa aacaagaaaa cgaaacaacg ctatttcatc aagatggcgg ataaagtcgt
    12481 caaatataat ttcttggggg ctgggctgac ttacctattg acaggttctt tttctaaggc
    12541 tatttctttc ctattggtcg atttctcctg cgctttgaaa atctctactc ctgtagctta
    12601 tttgacagtt atcaaggaag ggttgaaccg tgaaatggtg attaaggatg gagatgttct
    12661 ggagaaatat ctggaagttg atactttctt gtttgataag acaggaacaa tcacaactag
    12721 ttatcctata gttgaaaagg tgttaccttt tggagactat agtgaggaag atattctcag
    12781 aatcagtgcc tgtcttgagg aacacattta tcatcctatt gctaatgcca tcgtcaagca
    12841 agctgagata gagggaattg aacatgagga aatgcatggg aaactccaat atatcgcaag
    12901 caaggggatc aaatctcata tagatggcca accagttctt attgggaatt atgtcttgat
    12961 gcaggatgag cagattcata tcagttcaga acaaaatgct ttaattgaag agtacaagag
    13021 tcactacaat ctcttattct tggcttatca aaatgaattg attggaatgt tctgcattca
    13081 tactcctttg agaaaagaag caaaaacagc cttggataaa cttaaggcac aggggaaaaa
    13141 attgattctg gcaacaggag acaccttgat taggacagag gaattagtca aagatttgcc
    13201 ctttgatcag gtctatacag acttgaaacc tgatgggaaa tttgagttag tagagaaact
    13261 gcagaaagca ggtcacacta ttttgatggt tggagatgga ttgaatgact cagcggcttt
    13321 aactctatca gatatcggtg tggtgatgaa tgagagtgca gatatttcta agcagatgag
    13381 tgatatctta ttgttagata atcgtttgga tttcttccaa gagttggatt cgttatcatc
    13441 atctttgcaa acactcatca agaaaaatat tcaggatacc gttgtcgtaa atagtagttt
    13501 gattggcttt ggcttattta attggttcag tccttcaaat ctctctatct tacataatct
    13561 aacaaccttg cgcattgtcc tgcgtagcct gtctattaaa aatagataga tgagagttat
    13621 taacagcaaa aaggagttac ctttctcgag gttaactcct ttgtttatag ataaatgttg
    13681 aatagtttag taagtcaata caaagtattt tttcttccca cgacggataa cagtcagttc
    13741 attttctaac ttatcagcgt cactcaagac atagtcaagg tcttggatgc ggtcgccgtt
    13801 tacgtagatg gctccgtttt ggacgtcttc acgggcttgg cgttttgagt taactatacc
    13861 agatgagacg agcagttcca cgatattgtt gttttcgtct gcctgtactt ggtagtttgg
    13921 cacaccacga agtccttgtt tgagctcttt gacagaaagg tttttgatgt ttcctgcaaa
    13981 gagttgctca gtgatgttaa gtgcttcttt gtaggcttct tctccgtgaa caagtgtaac
    14041 aacttcacga gccaagactt tttgagccaa gcgttcgtgt ggcgctgctt caaattgttt
    14101 acgaatatct tcaatctcat caagtgacaa gaaagtaaag attttcaaga agcgaacagc
    14161 gtcagcgtcc atcacgttca tccagaattg gtacatttcg tatggagaag tcttttcggg
    14221 attgagccag acggcatttc cttctgattt accaaatttt ttaccagttg catctgtgat
    14281 tagtggaaca gtgataacgt gaccagtctt gtccgcctta cgacgaagca attcggtacc
    14341 agctgtcata tttccccact ggtcagaacc accgatttga agagtgacat tatggtcttg
    14401 gttaaggacg aagaagtcgt acccttgcat gatttggtaa gcgaactcag tgtaagaaat
    14461 tcctgtttcg atccgttttt taacagattc cttactcatc atgtagttga ccgtgaagta
    14521 ttttccaatg tcacggagga agtcaatgaa gctgatgctg ccaaaccagt cgtagttgtt
    14581 gaccatgaca gccttgtttt cgccattttc aaagtcaaga aaacgagaaa gttgtccttg
    14641 gatagacttg acccagccat ctactgtgtc ttttgtttgg agactacgtt cagcatcttt
    14701 gaaggacgga tctccgatga gacctgtagc accgccaacg agcgcataag gtttgtgacc
    14761 tgctagttgc aagcgacgac ttgtcaagat tgcgacaagg tggcctaggt gaaggctgtc
    14821 agcagttgga tcgtagccag tataataaga aacttgacct tcttctaggg ctttacgcaa
    14881 agcttcttca tcagtcgttt gaaatatcaa accacgctct tttagctcat caaaaatgtg
    14941 catgtgtctt ttctcctttt taaaattatt gtttctacct attgtatcac aaacttgggc
    15001 aatagcctag cagaataggg aagaaagtgg ctattttatt gaaaatttcc cttttgtggt
    15061 ataatagata gagtgaggaa atccatgcaa aatcaattaa atgaattaaa acgaaaaatg
    15121 ctggaatttt tccagcaaaa acaaaaaaat aaaaaatcag ctagacctgg caagaaaggt
    15181 tcaagtacca aaaaatctaa aaccttagat aagtcagcca ttttcccagc tattttactg
    15241 agtataaaag ccttatttaa cttactcttt gtactcggtt ttctaggagg aatgttggga
    15301 gttgggattg ctttggggta cggagtggcc ttatttgaca aggttcgggt gcctcagaca
    15361 gaagaattgg tgaatcaggt caaggacatc tcttctattt cagagattac ctattcggac
    15421 gggacggtga ttgcttccat agagagtgat ttgttgcgca cttctatctc atctgagcaa
    15481 atttcggaaa atctgaagaa ggctatcatt gcgacagaag atgaacactt taaagaacat
    15541 aagggtgtag tacccaaggc ggtgattcgt gcgaccttgg ggaaatttgt aggtttgggt
    15601 tcctctagtg ggggttcaac cttgacccag caactaatta aacagcaggt ggttggggat
    15661 gcgccgacct tggctcgtaa ggcggcagag attgtggatg ctcttgcctt ggaacgcgcc
    15721 atgaataaag atgagatttt aacgacctat ctcaatgtgg ctccctttgg ccgaaataat
    15781 aagggacaga atattgcagg ggctcggcaa gcagctgagg gaattttcgg tgtagatgcc
    15841 agtcagttga ctgttcctca agcagcattt ttagcaggac ttccacagag tcccattact
    15901 tactctcctt atgaaaatac tggggagttg aagagtgatg aagacctaga aattggctta
    15961 agacgggcta aggcagttct ttacagtatg tatcgtacag gtgcattaag caaagacgag
    16021 tattctcagt acaaggatta tgaccttaaa caggactttt taccatcggg cacggttaca
    16081 ggaatttcac gagactattt atactttaca actttggcag aagctcaaga acgtatgtat
    16141 gactatctag ctcagagaga caatgtctcc gctaaggagt tgaaaaatga ggcaactcag
    16201 aagttttatc gagatttggc agccaaggaa attgaaaatg gtggttataa gattactact
    16261 accatagatc agaaaattca ttctgccatg caaagtgcgg ttgctgatta tggctatctt
    16321 ttagacgatg gaacaggtcg tgtagaagta gggaatgtct tgatggacaa ccaaacaggt
    16381 gctattctag gctttgtagg tggtcgtaat tatcaagaaa atcaaaataa tcatgccttt
    16441 gataccaaac gttcgccagc ttctactacc aagcccttgc tggcctacgg tattgctatt
    16501 gaccagggct tgatgggaag tgaaacgatt ctatctaact atccaacaaa ctttgctaat
    16561 ggcaatccga ttatgtatgc taatagcaag ggaacaggaa tgatgacctt gggagaagct
    16621 ctgaactatt catggaatat ccctgcttac tggacctatc gtatgctccg tgaaaagggt
    16681 gttgatgtca agggttatat ggaaaagatg ggttacgaga ttcctgagta cggtattgag
    16741 agcttgccaa tgggtggtgg tattgaagtc acagttgccc agcataccaa tggctatcag
    16801 accttagcta ataatggagt ttatcatcag aagcatgtga tttcaaagat tgaagcagca
    16861 gatggtagag tggtgtatga gtatcaggat aaaccgattc aagtctattc aaaagctact
    16921 gcgacgatta tgcagggatt gctacgagaa gttctatctt ctcgtgtgac aacaaccttc
    16981 aagtctaacc tgacttcttt aaatcctact ctggctaatg cagattggat tgggaagact
    17041 ggtacaacca accaagacga aaatatgtgg ctcatgcttt cgacacctag attaacccta
    17101 ggtggctgga ttgggcatga tgataatcat tcattgtcac gtagagcagg ttattctaat
    17161 aactctaatt acatggctca tctggtaaat gcgattcagc aagcttcccc aagcatttgg
    17221 gggaacgagc gctttgcttt agatcctagt gtagtgaaat cggaagtctt gaaatcaaca
    17281 ggtcaaaaac cagggaaggt ttctgttgaa ggaaaagaag tagaggtcac aggttcgact
    17341 gttaccagct attgggctaa taagtcagga gcgtcagcga caagttatcg ctttgctatt
    17401 ggcggaagtg atgcggatta tcagaatgct tggtctagta ttgtggggag tctaccaact
    17461 ccatccagct ccagcagttc aagtagtagt tctagcgata gcagtaactc aagtactaca
    17521 cgaccttctt cttcaagggc gagacgataa ttctctaaat gaagtggcca atcaatggat
    17581 tgccactttt ttcctttcgt gttacaataa gggtatgaat cagtatcaga aaaagattgt
    17641 taacggaaaa atttattcgc tcctatccgg cttaatatgg ggaatctgtg gaattttagg
    17701 agagtacttc tttactcatt atcaggtgtc ttcgggctgg attacctcta tgcgtttgac
    17761 actggcaggg agtattgtac tcatttggtc tgcaatacaa ttaaaatcgc aagtgctaga
    17821 tatttggcga gacaagaaaa attacctgcc ctttttagcc tatgctattt tggggatttt
    17881 ttcagtccag tattttttct atctctgtgt agaatactca aatgctacga cagcaactat
    17941 tttacagttt attagccctg tctttatcct cttttacaat cgcttggttt atcaaaaacg
    18001 agcgtcaaaa agcgctgttt tctatgtttt ggttgccatg ctgggtgttt gcttgatggc
    18061 gacaaaggga gatctctctc agttatccat gacgccgcta gctcttataa caggtttgct
    18121 gagtgccatg ggtgttatgt ttaatgttat cttgccccaa ccttttgcta agcgttatgg
    18181 ttttgttcct acggttgggt gggggatgat tttggcaggt ttgtttagca atgtcctctc
    18241 gccggtttat cagctttcct ttactcttga tatttggagt atcttgattt gcctcattat
    18301 cgctttcttt ggaacggctt ttgctttttt catttccatg aaggctgtgt ccttggtttc
    18361 tcctttggtg gttgccgtta tcagtgccag tgaacctctc tcttctgctc tcttgagtgt
    18421 tttgttctta ggattagtag tggattggtc cctccttcta gctatagtct tgattatttt
    18481 acccatgata tttttgtcta tagaagaagc gaaagaaagt agataaaaag tcttttctta
    18541 attctaaaag tgtgctatac tagaatagtc aataaaacac ggggagatag ttgtgaagag
    18601 tgtttttagg ttgtatcggt aggggcttgc ttttaccgac agcacgtttt atctcacaac
    18661 cctaaaaaat catacctaaa aacagacaaa aaggtttcaa atttgaggcc ttttttggta
    18721 gaataggtat cattataacg aaccaggagg cacctatgac tgctacaaaa atgaacgctc
    18781 aagaaattat ccaatttatc gccaatgctg aaaagaaaac cagtgtcaaa gtaacctttg
    18841 aggggcaact cgcaactgct gtgcctagct ctgttgtcaa actaggaaat gtcctattcg
    18901 gagactggaa ggacgtggct ccgcttcttg aaggtttggt agaaaatcaa gattatgttg
    18961 tcgagcaaga tgctcgtaat tctgcagttc ctttgctaga taagcgtgct atcaacgctc
    19021 gtatcgagcc aggtgctatt atccgtgacc aggtggaaat tggtgacaat gctgttatca
    19081 tgatgggagc tgttatcaat atcggtgctg aaatcggtgc tggaaccatg attgacatgg
    19141 gtgccatcct tggtggccgt gccatcgttg gaaaaaatag ccacgttggt gcaggtgcag
    19201 ttttggcagg tgtgattgag ccagctagtg ctgaaccagt ccgtgtcgga gacaatgttc
    19261 ttatcggggc taatgcagtg gttatcgaag gagtccaaat cggtagtggt tcagttgtcg
    19321 ctgcaggagc tatcgttacc caagatgtcc cagaaaacgt ggtagtagca ggtgttccag
    19381 ctcgtatcat caaagaaatt gatgcccaaa cccaacaaaa aacagcgcta gaggatgcgc
    19441 ttcgtacctt gtaattgtaa aagtaaaaaa gaggcggaac cctttttcca gcctctttct
    19501 gctatatcgg aggacagata gatgttagat ttgattcaga ctagacgagc tttacaccag
    19561 attccagaga ttggcttgga ggagttcaag actcaggctt atttgctgga tgtgattgag
    19621 aaattgacta cgggcaagga ttttgttcaa attcgtactt ggcggacagg gattttggcc
    19681 tacctgcagg gaagtcagcc ggagcgaacc attggttggc ggacagatat tgatggcctg
    19741 cctatcgtcg aacaaacagg tctacctttt acttctcaac accaaggtcg catgcatgcc
    19801 tgtggtcatg attttcatat gaccattgcc ttaggctgtc ttgagcgcgc ccttgaggag
    19861 caacccaaga ataatctgct ctttctattt cagcctgctg aagaaaatga agctggtggt
    19921 atgctcatgt atgaggacgg tgcttttgga gattggttgc cagatcaatt ctatggtctc
    19981 catgttcgtc cagatttgaa agtcggccag attgcgacta atactcatac actctttgca
    20041 ggaacttgcg aggtgaagat ccgtttcaaa ggtaaaggtg gccacgcagc ttttcctcat
    20101 gaagccaatg acgccttggt ggcggctagt tactttgtga cccaagtgca gtcagttgtt
    20161 agccgcaatg tcaacccaat cgagggagca gtggtgacct tcggcgtttt tcaagctgga
    20221 accaccaaca atgtcatcac agacacagct tttttacatg gaactattcg tgccttgaca
    20281 caggacatga gtctcttggt gcaaaagagg gtaaaaacag ttgcagaagg ggttgcagct
    20341 gcctttgata tggaagtcga agtggaactc aaacaaggtg gatacctacc tgttgagaac
    20401 aatccagcct tggcgcgtga actgatggac ttctttgacg agaaagacgg aatcgagttg
    20461 attgatatcg aacctgctat gacaggcgag gactttggtt atctcctttc aaaggttgat
    20521 ggcgtgatgt tttggctagg tatcgatagt ccctacgctc ttcatcaccc tcaaatgagt
    20581 cctaaggaag aagtcttagc tattggggtg gctgcggtgt ctagtttcct gaaaaagaag
    20641 gcagcagaat agagggcttg tctatgaaat cggaattacg caagcaagtc ttgcatgaaa
    20701 tgaaggctat atctcaagag caaaaacagg ctatagacca agctttaacc gagcgaattt
    20761 tacaacaccc cttttatcaa gaagccaagg tcatcgcaac ctacctctct ttttctcatg
    20821 agtttcaaac gcgggaactg attgagcagg cgctgaagga cggcaagaag gttttgacac
    20881 ctaagaccta tcccaagggg cgcatggatt ttgtggtcta tgatccgcaa cagttggtaa
    20941 aaacttcctt tggattactg gagccacagg gagatttgga agttgtggat gtttcaaaga
    21001 ttgatttgat tcatgttcct ggtctggctt ttacgacaaa aggatatcgg ataggatacg
    21061 gtggaggcta ttatgaccgc tatctggaac atttttctgg tcgtgctttg agtacgatat
    21121 atccttgtca aattcaggac tttatacctg aaaaccatga tattcctgtt caggaggtat
    21181 taattgatga aggaaatctt tgatagacgt taccctgtga cgagtttctt cctcttagtg
    21241 acggccttgg tatttttact aatgttggtc actgcaggcg gaaactttga cagggcagat
    21301 acattatttc gatttggagc catgtatggg tcagctattc gcctctttcc cgagcaggtt
    21361 tggcgtctct tgtctgccat ttttgttcat attgggtggg aacatttcat tgttaatatg
    21421 ctttcacttt attatcttgg aaggcaggta gaggagattt tcggttctaa gcagtttttc
    21481 tttctctatc ttttatcagg aatgatgggc aatctctttg tttttgtatt tagtcctaaa
    21541 tccttagcag caggcgcctc tacctctctt tatgggctat ttgccgcgat tattgttctt
    21601 cgctatgcaa ctcgcaatcc ttatatccaa cagctagggc aatcctatct gacacttttt
    21661 gtggttaaca ttattggaag tgttctgatt ccaggaatca gcctagcagg ccatatcggt
    21721 ggtgcagttg gtggcgcatt tctagcagtt atctttccag ttagaggaga aaaacggatg
    21781 tataatacca gccagagatt aggagcggta gtcttgttcg taggactcgc cattttgctt
    21841 ttctacaagg gaatgggaat gtgacgaagt tgaaagaaaa tttgtgtaat gaaaaaagat
    21901 aaggcatttt ttgaacctta tctttttatt ttattttatt ccttctcagt caattctttt
    21961 ccaagttgga tgaggtaatt cttcaaatca tctttgactt gtgggtgttt gagggcgtag
    22021 tcgatggatg ttttcatgaa gccaaacttg tctccgacat cgtaacgagc cccattgaac
    22081 tcacgagcaa atacacgttg tgttttattg agggtgtcga ttgcatctgt cagctgaatt
    22141 tcatttcctg cacctggagc ttggttttcg aggatttgga aaatttcagg cgtgaggagg
    22201 tagcgtccga taatagcaag gtcgctagga gcgtcctctg gagctggttt ttcaacaaag
    22261 gtttcaacac tgtaaagacc attttttcct tcgccttgcg gagcaataac cccgtaagca
    22321 gatacttcgt catgagggac tggcatgaca gcgatagtag acgcgtgggt acgctcgtag
    22381 tcatccatga gttgtttggt aagtggaaca gccttttcgt ctgtgatatc catcaagtca
    22441 tcaccaagca taacgacaaa aggttcattt ccgacgaaag ccttggcttg caaaacagca
    22501 tctccgagac cgcgtggatg agtttggcgg ataaaatgca gacgcatgtc agttgtttta
    22561 tcaactagct tcaaaagatc tgttttccct ttttctttga ggttatattc caattcgaag
    22621 tttgaatcaa agtggtcctc aatagaacgt tttgatttac cagtgacaac tagaatatct
    22681 tcaatacctg atttgagagc ttcttccacg ataaactgga tagttggttt gtctacgatt
    22741 ggcaacattt ctttggcaag ggccttggtt gctggtaaaa atcgagttcc tagtccagca
    22801 gcagggataa ctgcctttct aacttttgat gtcataaaaa tcctttctat agagggttaa
    22861 gaccactcat tttctgcttt aaattcattg ttcatgatgt cataaatggc atctttgata
    22921 ttggttccgt gataaataac ttggtaaata gcctgtgtaa tgggcatata gactccaagt
    22981 tcttgggcta gttcataggc tgctcgagtc gttgaaattc cttcgattac catgcccata
    23041 ttagcttcta tatcagctag ggattctcct cgtccgagag catctccagc tctccagtta
    23101 cgagagtgga tggaagttcc cgttacgatc aaatctccca caccagataa gccgctatag
    23161 gtcaatggac tggccccgag tgctacccct aggcgggtga tttctgctaa acctcgagcg
    23221 atgatggctg ccttagcatt atcaccaaat ccaagaccat gtaaagctcc agcaccgaca
    23281 gcaataatat ttttaagagc accagcagtt tcaaccccga taacatccgt attggtataa
    23341 agtcggaagt agtgattact aaatagcttc tgaacgtatt gagctgtttg taaatcttta
    23401 gaagcagcag ttattaaagt taggtcacgc acaatggtct cttctgcatg actaggccct
    23461 gaaacaacga cgatatcact acggagatgt tcaggaattt cttcttcaag aatggttgat
    23521 aatcgtttat ggctatcagg ttctaatccc tttgatgcgt gcatgatgat aaccttatgg
    23581 tccaaggttt gtgcaacttg ttgggcaaca agtcgtgtca cttttgttgg gacaacaaac
    23641 aaaatcgcat ccacatcttt caatgtttct gctaagtcgg tgtaggcaat gatattttcg
    23701 tctagaacga catctttaaa gtagtgctta ttagtatggt gtgtattaat ttcattgatt
    23761 tgctcgggaa gatttcccca aatacgtacc tcgtgtccat tgtcatttaa gacttgtgaa
    23821 agggcggttc cccaagaacc aggccccaag acggcgacgg tttgtttttc catgatttcc
    23881 tccttgatag agttctttct cttattctat catattctag gggattttgc acttgcatta
    23941 ctggggtatg gtggaaaaat acacaaaaac cgagacgaag ggataaactc ttagtcttta
    24001 gttaaagtga gaagaaatct gatagatagt ttgattcagt atatgcttat aatagaggta
    24061 aacaactcag gaggttcttg taggttgcga gagtttggcg aaaaaattaa aagattacgt
    24121 ttggctaaaa aaatcagtcg ttcagaattt tgtggtgatg agtctgaatt aagtatccgt
    24181 caattaatta gaattgaaaa tggagaatcc agaccaatac taacaaagtt aaaatatatt
    24241 gctgaacgtt tgggggttga agattacaag ttgatgccaa gttatataga gttggataag
    24301 gaatacctag aattgaagta tttcttgatg aggactccta catacgaaga tgaaactatc
    24361 gcccaaaaga aagagagtgt ttttgataag atttttgaag agtattatga taggctacct
    24421 gaggaagaaa gatttatcat cccaaattat tcatatctgg cactaacgaa ctatacagtt
    24481 caaaaattac cagaaaagct agttgaaata ctgtccttct ggtgattttg cttaatttct
    24541 gatgttcgag acatgattga ggagatttgt cttgattttt tcctaaaaaa gggcagactc
    24601 ctcccttggt ttgatgctcg atttttaaaa taaggtgact tattctgtta ggcatgtttt
    24661 cccctgccct ctagctttat atggaacagg gagtatcaga tttatctggc agattgtatc
    24721 aaataaggct tgaaactgtt ttgaataggc gtatagactt gagaatttga gaatatgtcg
    24781 tctagcagta gagacatatt ttccggcaat atgaaggaag agacgtcgaa aacgcttgat
    24841 agtcaaggcc tttacttcat caccagctag ctgctttaaa aagaggtaga gattataagc
    24901 cagacagccc atcatcatac gtacttcatt cttaatcatg gtcgaactat ctgtcttatc
    24961 cccaaagaat cctgctttcc tttctttgat aaagttttca gcattccctc gttcacgata
    25021 gaattgaaac agctcctcac tatctacact gcttaaattg gtcaaatgaa cttttttaca
    25081 accataaaaa agagcactta atcgtactct tctcttttaa ggattagttg aattaattca
    25141 aatccactag ttctcctgtt tctaggtaga ctaggcgttc acaaatgtta gcaatgtaat
    25201 cagcgaagcg ttccagatgc cctatgatat aaaggtattg tgttccattg ggaattgagg
    25261 tttcttggtc tttcataagt ccaatgattt cctttgataa ggcataataa tattggtcaa
    25321 tctgttcatc tttttgagca atactaatag cttttgaggc ttggtgcaaa ggaaaggcaa
    25381 ccaataaatc ggctagcatg ctgagggata atttacccat ttggtgtaac tgttcttcgt
    25441 caggggctag ttgattttct tttagttgca aaacagcttt agcaatgcct gccatatggt
    25501 ctcccatacg ttcaaggtct gaacaagaag acatgatgct aatcacaaat cgaaggtcag
    25561 acacttgtgg ctgctgcaag gccaacaaac gggcacaggt caattcgata gcgctttgac
    25621 cttggttgat agcatgatcc ttattgataa ttagctctgc catctccttg tctttggagg
    25681 ctaaggccag taaggctttt gaagctgttt caaggacaag ttgccctagt cctaaaaagg
    25741 attgttctaa ttcatgcaat tctaagtcaa attgatttct cataggtttt tccttcctta
    25801 tccgaaccgt cctgaaatat agtcttctgt gcgctgatct tttggattgg taaacacgtc
    25861 aacggtatct ccaaattcgc aaatttctcc tgttaagaaa aaagcagttt tatctgaaat
    25921 acgtgaagct tgttgcatgt tatgggtaac aatgataatc gtataatcct tttttagttg
    25981 ctgaatgagg tcttcaattt ttaaagtgga gatagggtct aaggctgaag tcggctcatc
    26041 cattaacaga acatcaggtt ctactgctaa agctcgcgca atgcaaaggc gttgctgctg
    26101 accgcctgat aaggacatgg cactcttttt aagattatct ttgacttcgt cccaaatggc
    26161 tgcccctttt aaagattttt ccactaaggc atctaattgt tttttgtctc gaataccatg
    26221 tgtccttggg ccataagcca cgttatcata gatagacatg gcaaagggat taggctgttg
    26281 aaaaaccatc cctacacgct tgcgtagctg attaaggttg aatttgctac tataaatatc
    26341 ttgctcatct aagaggactt ggccttcaat atggcaagaa ggaaccaaat cgttcatccg
    26401 attaagggtt tttagaaaag ttgatttgcc acaaccagat gggcctatca aggcagtaat
    26461 ctgtctttct ggtaattgaa tcgaaatatt ttttaaggct tgaaaatccc cgtaaaataa
    26521 gtctaggtgt ctgactgaaa atgttcccat actaggaagc tcctttcaca agtttccgag
    26581 ataataagct tgatagagta tttatcatta aaacagtaat aattaaaatc acgccggtag
    26641 cataggcttc attgacatgt agcccctcac ttgacagcat atacatatgt agggctagag
    26701 aacggcctga agacatgaga ctacttggcg tattggtaga ggtacctaat gtatacatga
    26761 gggcagctgt ttcaccaacg atacggccaa tagctagtat cactccagct aaaatacctg
    26821 gcatggcaac tggtagaaca attctaaaaa cagtccgtaa cttacctgcc ccaagtccat
    26881 aacttgcttg acgcatgcta tcactaacag ataaaagggc ttcttctgtt gagcgaataa
    26941 tgactggcaa caccatgata actgaggtta agattcctga taacagagag tattgaaaac
    27001 ctaagaagac tacaaagaag agcatgccaa acagaccaaa aacaatggaa ggaatcccag
    27061 acaaggtatc tgaggccaat cgcatgattt taacacaaag ggaatctttt tttgtatatt
    27121 ccacaagata aaaaccagca aaaatcccta tgggcaaggc taaaagaaga gcaccaaaga
    27181 ccagaataac ggtggaaata atcgctggca taagggaaat attctcagaa gtataagtcc
    27241 aagaaaagag ggatagactt agatgaggta agcctttgat gaggataaaa ccaatgatta
    27301 aaaagagaga gccaaaggtt aaagctgaaa aacaataaac gagaagtttt agcaggtatt
    27361 tactcataag atgattttcc tttcaagtag gcaaagtagg cattaatcaa gagaataagg
    27421 aaaaagagaa ctgctgaggt tgcaataagg gcttccctat gctgacctga tgcgtaagcc
    27481 atttccagaa caatattggt tgttaaggtt ctggttcctg aaaagagtcc acttggaata
    27541 atcggctggt tgcctgccac caaaataact gccatggttt cacctactgc gcgaccaatt
    27601 cctaaaataa ctgctgataa aataccagat ctcgcagctg gcaagatgac actaaaaata
    27661 ctccgttcat gactagctcc tagagccaag ctaccagaat aatacgtttt gggaactgtt
    27721 cggatagcag attctgacaa actgataatg gttggcaaaa tcattattcc taatagtaac
    27781 gaagcggtta ggacactcat gccatttcct aaaaaggttc taatccaagg caccaataat
    27841 tgtaggccga aaaaaccata aacaatagat ggaatggccg ccatcaagtt gatagctgat
    27901 tttaagaagc catagacggg ctttggacaa taataaacca taaacaccga tgtcaagatg
    27961 cctgttggca ccccaatcac aatcgctcct aaggtaatta ataaggaacc aacgatcatt
    28021 ggtaaaatac catagcttgc cggaatgttc gttggcgacc aatcactgcc taataaaaaa
    28081 cgggcaaagc cgtagttagc catgaaaggt aagccattac taaaaataaa gaaacagatt
    28141 agcaaaatag ctacaacagc tactgttgca ctcatgaaaa aaattgccct aaaaactgct
    28201 tctttgaagg cttgttttgt cacatcttgt cctttctagt gaagaaagta agggagatac
    28261 gacacctccc tacttgcctt ctttatctta ttgtacgatg aaacgtctgc atctctttag
    28321 agatttatgg agcaaacatt ttatttaatc ttgtcccagg tggttaattt gccactaaaa
    28381 acgtctgcaa gttcagccat actgacttgg cttgccttat tgtcattatt gaccacaaca
    28441 gcaataccgt ctaaagcaat agcatcatgg gtgagacttt taccttcttc aggagttaat
    28501 tccctagaaa ccataccaat atcagcggtt ttctccttaa cagcggtaat acctgctgaa
    28561 gacccattag aggtaatatc aatcgtaact tctggatttt cttttttata agcttctgct
    28621 aatttttcca ttaaagaaga tactgaagtg gaacctacaa cagacaactt gcctgataag
    28681 tgttggcttg tatattctgt ggtttcggtt ttagcttcaa taaatttatt atctgtgacc
    28741 acttgttgac cttgtttgga gtggataaag ctgataaaat cttgacctag cttggaaaga
    28801 ttagaagacc aaacaatgtt gaagggacgt tgaagagggt attcaccatc taaaactgtg
    28861 tctcgactag ccttgacacc atcaatctct aaagccttga cagatttcgt taaagatccc
    28921 aaggagatgt agccgatagc attagcattc ccttgaactg ctgagagaac accttctgta
    28981 ctattttgaa tcacagctgt tttggcagtg ttgtcaattt ttttatcacc gtcttttttg
    29041 agaatccctg tgatttctgt gaaggcaccc cgtgttccag agccattttc tcgtgaaatc
    29101 acctcaatcg ttcctgaagc tgactgtttg gaagcagctg actgattgcc acaggcaaca
    29161 agcccaaatc ctgataagcc aatggctgca agagtaagca tttttttgaa tttcataata
    29221 atcaccttta tctctatgta tttttcttgt gtaggcttac tacatttata gtctaacaag
    29281 tctttgtaaa ggtttatccc tgattcatgt aaagattgtg taaagaatca aaaaaagcca
    29341 cttttgaaaa atggctgctc ctaaaaatag ctttaaaaat tattagtcct gtgcgaaaga
    29401 ttggttagga agaaaaatcg tgaagcaact gcctctgcca agctgactcg tcaccgtgac
    29461 ttggccactt aataattgac tgagttcttt gacaatggca aggccaagac cagtgccacc
    29521 agtttgtctg cttcgacctt tattaactcg gtaaaaacgt tcaaaaatac gatcctgctc
    29581 taattgacta ataccaatcc ctgtatctga tacagaaatc ttaatgcctt cgttcacctt
    29641 ttgggtcttg acctcaattt ttcccccttg ttcagtgtaa cggatggcat tggataaaag
    29701 attgagtaag atttgggaaa gtaattgact atctgatacg agggtgacat catctggcac
    29761 ctgcaccttt agctgtaaat ccttcttctt gagctgaggt tgcaagcttt gagtcaaatc
    29821 ctgtacaaat tctgccaaag aaagggtcgt ccattgtata ggcatttgtt gagccttaga
    29881 taaggtaaga agatgctcaa caatatgctc aagacgcaaa ctttctttgt aaataatgtc
    29941 tagaaagtca tccttgagcg cttcttcttc agctgacatc cccttaatgg tttcagcaaa
    30001 gcccttaatc gaagtaactg gtgtcctcaa ttcatgggag gcatttgaga caaaggctaa
    30061 atttaacttt tcataagttc taatcgttgt taaatcatat agcaagacga gcacagcttc
    30121 cacagattgg gtggggctaa aaacgggaac tgctgtcact tctaaaatca agtcaccctc
    30181 atgaaaccca cttacttctt gttttaacct tgttttttga tcaaaggctt ggtgaactaa
    30241 atttcgaata tccatccgtt tgaggtcatc aagtgaactt atgtcgccgt ccacatcggg
    30301 aaaataatga ggcagagagc gactggataa taacatctga ccttgagcgg aaactaaaaa
    30361 cgtccccatg gttaggtgcg acagaagaac ctccattgtt tcggctaggt ccttgtattg
    30421 ctgatcctgt tgggagactt tggtttttag ggcagacaca tactgagcca aagactttaa
    30481 gtcttcttgc cctttttcta aaaagtattc actactggtc aagagaggtt ggtgcaaggt
    30541 ctcaaaagca acttcccatt tccaaaggca aaagagccag tagccaccta gtcccaaaga
    30601 aagggctaga agaaagagac cgatgccttt actgatccaa gttaatgcca tccctgcaat
    30661 cagaatgagg ctaacactta gattgactag ccaaaattga aggtagcgtt tcatctataa
    30721 ctccttgaac ttataaccat acccccgaat ggttcgaata aattgagggg ctttaggatt
    30781 gtcttcaatt ttttccctta acttaccaat atgaacgtcc accaaacgtg tttcctgccc
    30841 aaagtcatac ccccagatac gttccaaaag acgctctcta gtcagtgtca tgttgggatg
    30901 tttcataaga tagagcaaga gttcaaattc ttttggggtc aaactcagta acttattcgc
    30961 cttgtagact tcatgacgct cagggtatac tttcaaggtc ccaaatagcc aagaatcgtc
    31021 agcgatatta tctgaatcat ctccttcttg ttctccttta gttcgcctga gaacagcctt
    31081 gacacgcgcc agcaattctc tagggctaaa aggcttggtc aggtagtcat cagcccctaa
    31141 ttccaaggcc aaaaccttat caaattcatc acttttcgca gaaaccatca taattggagt
    31201 tttgacgcct ttggctctca gccgcttaca aacttccatg ccatctaatt gtggtaacat
    31261 gatatcaagc aagataaaat caaagggttc tgtttctgcc aaagctaagg ccttccgtcc
    31321 atttgttacc aattgagtag aaaagccttc cttacttaaa tggtagtcaa gcaatttcag
    31381 aatgtgttct tcatcatcca ctaataagac ttgttttgtc atctattatc tcctattggt
    31441 aacattataa cacaattatc agaaatccta acattgctaa atcagattaa atttgcttat
    31501 caagactagt atctggtcaa acgctcaatc atctccttgt gctctggata ggtcgccagt
    31561 agatctaccc tttcaaataa ttcaaaatcc tcaaattcaa aaccaggagc aacaagacaa
    31621 gaaaccagag catcatcctt atcaactgtt gatccccaaa tagtgccctt aggaacacag
    31681 tagtgaagtt gttgcccttt ggatatgtcc aggcctaaag tgactgcttc gtagtgacca
    31741 tctgctgtaa tcatgtgaac agtaagtggg gattctgcat gaaaatacca gatttcatct
    31801 gctgtcaatc ggtgaaaatg tgaaggattc gtttcttctt aataagaaat aaatactggt
    31861 ataaagcgcc cttcccttac cagcaaggtt tatagtgtct gaagcttttt ttgtttgtct
    31921 aaaatagcca ccttcaacat ggggagctaa ctctagagtt cttatcaagt cttctttatc
    31981 cgtcggagcc aatgggttga agtaactctt gttcaaagtg gtgttacgat ttcaagaact
    32041 cctctcagtt ctgaggacac ggtaatgatt gatgcgacgg aagtacaaat caatcgccct
    32101 aaaagaagaa ttagcgaatg attctggtaa aaaaaatgcc acgctatgaa ggctcaagcg
    32161 attgtcacaa gtcaagggag aattgtttct ttggatatcg ctgtgaacta ttgtcatgat
    32221 atgaagttgt tcaaaatgag tcgcagaaat atcggacaag ctggtaaaat cttggctgac
    32281 agtggttatc aagggctcat gaagatatat cctcaagcac aaactccacg taaatccagc
    32341 aaactcaagc cactaacagt tgaagataaa gcctataacc atgcgctatc caaggagaga
    32401 agcaaggttg agaacatctt tgccaaagta aaaacgttta aaatgttttc aacaacctat
    32461 cgaaatcatc gtaaacgctt cggattacga atgaatttga ttgctggtat tatcaatcat
    32521 gaactaggat tctagttttg caggaagtct attatttggt taggtgaatt agtgaagtgt
    32581 ttaggcaagt gtctctggtt acgacgtcat ggcctctaaa tcgattatat ttaggggtca
    32641 tgactagtga agcagttagc tagttcgcat ataagcggct agcgtctaac aattaggaac
    32701 tttagttcca ataactttaa gattacgacg ttttaggaca taaatcgatc atatttatgt
    32761 cctaaaacta gtgaagcgcc tagccaaagt ccgaatagga tttggcgtta gttacttaga
    32821 ttgctttgca atcaagtaac tttggcgatt tacatcttct ctggcgcttc tactccaagc
    32881 aagcgaaggg cttctttgag aacgactgcg gttgcgtagc tgagggctag acggctgtcg
    32941 cgttctgggc tttcatccaa gatacgtgta tgtgcatagt atttgttaaa ggattgagcc
    33001 aggctaattg caaatttagc aatgatagaa ggttcaaagt tatctgccgc acggttgata
    33061 atacgtggga agtcttgaat gagtttaatg atttcccagc tttcagtatc attcaagcta
    33121 tagttgccag ctgtttctgg tttgaaatcg gctttgcgta agatagattg gatacgagcg
    33181 taggcatatt gaacgtaagg tccagtttca ccctcgaagg ataccatagc ctctaggtcg
    33241 aagtcgtatc catttgtacg gtcggttttg aggtcataga atttaatggc tccaacccca
    33301 acagcatgtg ctacctgatc tttattttcc aattcaggat ttttagcctc gatttggacc
    33361 ttggcacggc taacagcctc tgcaacagta ggctctagca agatgacatt ccctttacga
    33421 gtagagagct tcttcccttc ttttgtaacc agaccaaaag gaacgtgggt aatgtcgtca
    33481 ctccaatcgt agcccatctc ttgcaagaca gctttgagct gtttaaagtg ggcagattgt
    33541 tcttgaccaa cgacatagat agatttagca aattggtatt cgtttttacg gtagagggct
    33601 gcagccaagt cacgtgtgat atagagagtt gcaccatcag acttcttgat gagggctgga
    33661 tgttcaattc catatttctc aagattcaca acttgggcac cttctgattc aagaagtagt
    33721 cctttttcag aaagaatgtc tacaactgca tccatcttat cattgtagaa ggcttctccg
    33781 ttatagctgt caaattcaac cttcaattca ttgtaaaggc ggttaaattc cactaaactt
    33841 tcatcgcgga accattgcca aagagcgaga gcttcctcat ctccattttc aagtttacgg
    33901 aaccattcgc gcgcttcttc atccaagcta gggtcatttt cagcttcagc gttgatgcgg
    33961 acatagagtt taaggagttc atcgattgga tgagctttta cagcttcttc gtcgccccat
    34021 tttttgtagg caacaatcaa catcccaaat tgtttacccc agtctcccaa atggttgacc
    34081 ttgaccgttt gataaccgat tttttggaaa atatgtgaca agctatctcc gataacagtt
    34141 gaacgcaggt ggccaataga aaatggttta gcgatattcg gactagacat gtcgataaca
    34201 acattttctt gtttaccaat attttggtca gcatagtgtt ctttttcagt ggtaacagct
    34261 tgcaatactt gagcagaaat ggcagattta tcaaggaaaa agttaacgta aggtcctgtt
    34321 gcgacaactt tttcaaaggc ttggctgttc attttttcag ccagttcagc cgcaatcatt
    34381 tgtggtgctt tacgttcgac tttggcaaga gaaaaagcag ggaaagcgat gtcacccatt
    34441 tctgagtttt taggggtttc cagtaacttt aaaatagcct cttggtccag gctatcaatg
    34501 atgctagcca attcgctagc aatcaattct tttgtattca ttaagagctc ctttttggac
    34561 ttttctacta ttttatcaca attttaaaga aagaagaaaa aatttttgaa atctcctgtt
    34621 tttttggtat aatatggtta taaatatagt tataaatatg cacgcaagag gattttatga
    34681 gaaaaagaga tcgtcatcag ttaataaaaa aaatgattac tgaggagaaa ttaagtacac
    34741 aaaaagaaat tcaagatcgg ttggaggcgc acaatgtttg tgtgacgcag acaaccttgt
    34801 ctcgtgattt gcgcgaaatc ggcttgacca aggtcaagaa aaatgatatg gtgtattatg
    34861 tactagtaaa tgagacagaa aagattgatt tggtggaatt tttgtctcat catttagaag
    34921 gtgttgcaag agcagagttt accttggtgc ttcataccaa attgggagaa gcctctgttt
    34981 tggcaaatat tgtagatgta aacaaggatg aatggatttt aggaacagtt gctggtgcca
    35041 ataccttatt ggttatttgt cgagatcagc acgttgccaa actcatggaa gatcgtttgc
    35101 tagatttgat gaaagataag taaggtcttg ggagttgctc tcaagactta tttttgaaaa
    35161 ggagagacag aaaatggcga tagaaaagct atcacccggc atgcaacagt atgtggatat
    35221 taaaaagcaa tatccagatg cttttttgct ctttcggatg ggtgattttt atgaattatt
    35281 ttatgaggat gcggtcaatg ctgcgcagat tctggaaatt tccttaacga gtcgcaacaa
    35341 gaatgccgac aatccgatcc ctatggcggg tgttccctat cattctgccc aacagtatat
    35401 cgatgtcttg attgagcagg gttataaggt ggctatcgca gagcagatgg aagatcctaa
    35461 acaagcagtt ggggttgtta aacgagaggt tgttcaggtc attacgccag ggacagtggt
    35521 cgatagcagt aagccggaca gtcagaataa ttttttggtt gccatagacc gcgaaggcaa
    35581 tcaatttggc ctagcttata tggatttggt gacgggtgac ttttatgtga caggtctttt
    35641 ggatttcacg ctggtttgtg gggaaatccg taacctcaag gctcgagaag tggtgttggg
    35701 ttatgacttg tctgaggaag aagaacaaat cctcagccgc cagatgaatc tggtactctc
    35761 ttatgaaaaa gaaagctttg aagaccttca tttattggat ttgcgattgg caacggtgga
    35821 gcaaacggca tctagtaagc tgctccagta tgttcatcgg actcagatga gggaattgaa
    35881 ccacctcaaa cctgttatcc gctacgaaat taaggatttc ttgcagatgg attatgcgac
    35941 caaggctagt ctggatttgg ttgagaatgc tcgctcaggt aagaaacaag gcagtctttt
    36001 ctggcttttg gatgaaacca aaacggctat ggggatgcgt ctcttgcgtt cttggattca
    36061 tcgccccttg attgataagg aacgaatcgt ccaacgtcaa gaagtagtgc aggtctttct
    36121 cgaccatttc tttgagcgta gtgacttgac agacagtctc aagggtgttt atgacattga
    36181 gcgcttggct agtcgtgttt cttttggcaa aaccaatcca aaggatctct tgcagttggc
    36241 gactaccttg tctagtgtgc cacggattcg tgcgatttta gaagggatgg agcaacctac
    36301 tctagcctat ctcatcgcac aactggatgc aatccctgag ttggagagtt tgattagcgc
    36361 agcgattgct cctgaagctc ctcatgtgat tacagatggg ggaattatcc ggactggatt
    36421 tgatgagact ttagacaagt atcgttgcgt tctcagagaa gggactagct ggattgctga
    36481 gattgaggct aaggagcgag aaaactctgg tatcagcacg ctcaagattg actacaataa
    36541 aaaggatggc tactattttc atgtgaccaa ttcgcaacta ggaaatgtgc cagcccactt
    36601 tttccgcaag gcgacgctga aaaactcaga acgctttgga accgaagaat tagcccgtat
    36661 cgagggagat atgcttgagg cgcgtgagaa gtcagccaac ctcgaatacg aaatatttat
    36721 gcgcattcgt gaagaggtcg gcaagtacat ccagcgttta caagctctag cccaaggaat
    36781 tgcgacggtt gatgtcttac agagtctggc ggttgtggct gaaacccagc atttgattcg
    36841 acctgagttt ggtgacgatt cacaaattga tatccggaaa gggcgccatg ctgtcgttga
    36901 aaaggttatg ggggctcaga cctatattcc aaatacgatt cagatggcag aagataccag
    36961 tattcaactg attacagggc caaacatgag tgggaagtct acctatatgc gtcagttagc
    37021 catgacggcg gttatggccc agctgggttc ctatgttcct gctgaaagcg cccatttacc
    37081 gatttttgat gcgattttta cccgtatcgg agcagcagat gacttggttt cgggtcagtc
    37141 aacctttatg gtggagatga tggaggccaa taatgccatt tcgcatgcga ccaagaactc
    37201 tctcattctc tttgatgaat tgggacgtgg aactgcaact tatgacggga tggctcttgc
    37261 tcagtccatc atcgaatata tccatgagca catcggagct aagaccctct ttgcgaccca
    37321 ctaccatgag ttgactagtc tggagtctag tttacaacac ttggtcaatg tccacgtggc
    37381 aactttggag caggatgggc aggtcacctt ccttcacaag attgaaccgg gaccagctga
    37441 taaatcctac ggtatccatg ttgccaagat tgctggcttg ccagcagacc ttttagcaag
    37501 ggcggataag attttgactc agctagagaa tcaaggaaca gagagtcctc ctcccatgag
    37561 acaaactagt gctgtcactg aacagatttc actctttgat agggcagaag agcatcctat
    37621 cctagcagaa ttagctaaac tggatgtgta taatatgaca cctatgcagg ttatgaatgt
    37681 cttagtagag ttaaaacaga aactataaaa ccaagactca ctagttaatc tagctgtatc
    37741 aaggagactt ctttgacaat tctccacttt tttgctagaa taacatcaca caaacagaat
    37801 gaaaaggagc tgacgcattg tcgctccctt ttgtctattt tttaaggaga aagtatgctg
    37861 attcagaaaa taaaaaccta caagtggcag gccctggctt cgctcctgat gacaggcttg
    37921 atggttgcta gttcacttct gcaaccgcgt tatctgcagg aagtcttagg cgccctcctt
    37981 actgggaaat atgaagttat ttatagtatc gggacttggt tgattggtgt ggccgtagtc
    38041 ggtctagttg ctggtggact caatgttgtc ctcgcagcct atattgccca aggagtttca
    38101 tccgaccttc gggaggatgc cttccgtaaa attcaaactt tttcttatgc tgatattgaa
    38161 caatttaatg cgggaaatct agtcgttcga atgacaaatg atatcaacca gattcagaac
    38221 gttgtcatga tgaccttcca aattcttttc agacttcccc tcttgttcat cggttcgttt
    38281 atcctagcgc ttcaaacctt accttctctg tggtgggtga ttgttctcat ggtagtcttg
    38341 atttttggtt tgactgctgt catgatggga atgatggggc ctcgttttgc taaatttcaa
    38401 acccttcttg agcgcatcaa tgccattgcc aaggaaaatt tacgtggcgt tcgtgtggtc
    38461 aagtcctttg tccaagaaaa agagcaattt gctaagttta cagaggtctc agacgagctt
    38521 cttggtcaaa acctttacat tggttatgcc ttttcagtag tggaaccctt tatgatgttg
    38581 gttggttacg gggcggtctt cctctctatt tggctggtcg cgggaatggt tcagtcggat
    38641 ccgtctgttg ttggttccat cgcttctttt gttaattacc taagccagat tatctttacc
    38701 attgttatgg ttggattttt gggaaattct gtcagccgtg ccatgatttc catgcgtcgt
    38761 attcgagaaa ttcttgacgc agagccagct atgaccttca aggatatccc agatgaagag
    38821 ttggttggaa gtcttagctt tgaaaatgtg acctttacct atccaatgga caaggaaccg
    38881 atgctgaaag atgtgagctt tactattgaa cctggtcaaa tggttggtgt agttggagcg
    38941 actggtgcag gaaagtcaac cttggctcaa ttgattccac gtctctttga tccacaggac
    39001 ggggccatta aaatcggtgg caaggatatt cgagaagtga gtgaaggaac cctgcgtaaa
    39061 acagtttcca tcgttctcca acgtgccatt ctttttagtg gaacgattgc agataacttg
    39121 agacagggga aggggaatgc tactctattt gaaatggagc gcgcagccaa tattgcccag
    39181 gctagtgaat tcattcatcg tatggagaaa acctttgaaa gtccagttga agaacgggga
    39241 accaatttct ctggtggaca aaaacaaagg atgtcgattg cgcgtgggat tgtcagcaat
    39301 ccacgtattc tgatttttga tgattcgacc tcagccttgg atgccaaatc agagcgcttg
    39361 gtgcaagaag ctttgaataa ggacttgaag gggacgacaa ccattattat tgctcaaaaa
    39421 attagctcgg ttgtccatgc agacaagatc ttggttctaa atcaaggacg attgattggt
    39481 caaggcacgc atgcagactt ggttgccaac aatgccgttt accgtgaaat ctatgaaaca
    39541 cagaaatgaa agacaaacta taagaaaagt caatagtttt atctaaacta tttcttattt
    39601 caatttgatg atttggcgat gattttagag cacggcaaaa agctattgaa aaagtccatt
    39661 ttttcaaagg taatcctgtg ttaatttcag aaattacatc actttttgtt cgtcaaatgg
    39721 cagctctttt ttaggatata aaacagggtt cggataagtt tttttgcaag gtggatgatg
    39781 gctacattgt aatgttttcc ttgttctaac ttagtcttaa gataggcctt aaaagcaggt
    39841 gaaaagcgag ggcatgcttt ggcagcttgt atgagtacct accgcagatg aggggaaccc
    39901 cgtttgacca ttcttcctgc taaatcaatc tgacctgact gataaataga agaatccagt
    39961 ccagcgaaag cttgtaattg agcaggatta tcaaaggcat gaatatttcg aatctcggct
    40021 aaaatgaccg cccctaaacg attctcaatc ccagtaaccg tcgtgatgac cgagttgaac
    40081 tcagccatca agtcattgac acatgttttc gccttgtcaa tgagcctctt gtaatgtttg
    40141 atgttttcat tacaagagat aaaacgttta tgcgttatca aactcatgac caattgaaac
    40201 aaaaagctgt ggttagatcc tttcggaaat tgtcaagcga ttggaggaaa tgaactaatc
    40261 cacagcggct tattccaagt ataccacttg ggctttggca gtagctaact gcgctaaata
    40321 taatataagg aggagtaaaa tgaagacagt tcaatttttt tggcattatt ttaaggtcta
    40381 caagttctca tttgtagttg tcatcctgat gattgttctg gcgacttttg cccaagccct
    40441 ctttccagtc ttttctggac aagcggtgac gcagctagcc aatttagttc aagcttatca
    40501 aaatggcaat ccagaacttg tatggcaaag cctatcagga atcatggtca atcttggcct
    40561 gctggttttg gttctattta tctctagtgt aatatacatg tgtctcatga cgcgcgtgat
    40621 tgcagaatcg accaacgaga tgcgcaaagg cctctttggt aagcttgctc agttgacggt
    40681 ttctttcttt gaccgtcgac aagatggcga tatcctgtct cattttacca gtgatttgga
    40741 taatatcctc caagccttta acgaaagctt gattcaggtc atgagcaata ttgttttata
    40801 cattggtctg attcttgtca tgttttcgag aaatgtgacg ctggctctca tcaccattgc
    40861 cagcacccca ttggctttcc ttatgctgat tttcatcgtg aaaatggcac gtaaatacac
    40921 caacctccag cagaaagagg tagggaagct caacgcctat atggatgaga gcatctcagg
    40981 ccaaaaagcc gtgattgtgc aaggaattca agaggatatg atggcaggat ttcttgaaca
    41041 aaatgagcgc gtgcgcaagg caacctttaa aggaagaatg ttctcaggaa ttcttttccc
    41101 tgtcatgaat gggatgagcc tgattaatac agccatcgtc atctttgctg gttcggctgt
    41161 acttttgaat gataagtcta ttgaaacaag tacagcccta ggtttgattg ttatgtttgc
    41221 acaattttca cagcagtact accagcctat tatccaagtt gcagcgagtt ggggaagcct
    41281 tcagttggcc tttactggag ctgaacgaat tcaggaaatg tttgatgcag aggaggaaat
    41341 ccgacctgaa aaggctccaa ccttcactaa gttgcaagaa agtgttgaaa tcagtcatat
    41401 cgatttttca tacttgcctg ataaacctat tttgaaagat gtcagcattt ctgcccctaa
    41461 aggccagatg acagcagttg ttgggcctac aggttcagga aaaacgacta ttatgaacct
    41521 catcaatcgc ttttatgatg ttgatgctgg tggtatttat tttgatggta aagacattcg
    41581 tggctatgac ttagatagtc ttagaagcaa ggtgggaatt gtattgcaag attcggtctt
    41641 gtttagcgga acgattcgag acaatatccg atttggtgtg ccagatgcta atcaggaaat
    41701 ggttgaggta gcagcaaaag caacccacat tcacgactat atcgaaagtt tgcctgataa
    41761 gtacgatact cttattgatg atgaccagag catcttttca acagggcaga agcaattgat
    41821 ttcaatcgct cgaaccctga tgacagatcc agaagttctc attctcgatg aagcaacttc
    41881 aaacgtagat acggtgacgg aaagcaagat tcagcatgcc atggaggtgg ttgtagcagg
    41941 tagaactagt ttcgtcattg cccaccgctt gaaaaccatt ctcaatgcag atcagattat
    42001 tgtccttaaa gatggagaag tcattgaacg tggtaaccac catgaacttt tgaagctagg
    42061 tggcttttat tcagaactct atcacaatca atttgttttc gaataagaaa gaagttgtcc
    42121 tatgtgggca gctttttctt gtccataaaa aatgtttatc acagccttaa aaaaaacata
    42181 ttagacgaaa gtcattttga gtgatatgat aggactatcg ttagtattcg aaaggagagg
    42241 catcatggct agaacggttg taggagttgc tgcaaatcta tgtcccgtag acgcagaagg
    42301 caaaatcatt cattcatctg tatcttgtag attcgcagag atcattcgtc aagtcggtgg
    42361 tctcccttta gtcattcctg ttggtgatga gtcagttgta cgtgattatg tggaaatgat
    42421 tgacaaactc attttgacag gaggccaaaa tgttcatcct cagttttatg gagagaaaaa
    42481 gaccgtcgaa agcgatgatt acaatctggt ccgtgacgaa tttgaattgg cactcttgaa
    42541 ggaagcgctt cgtcagaata aaccaattat ggcaatctgt cgcggtgtcc aacttgtcaa
    42601 tgttgccttt ggtggaaccc tcaatcaaga aatcgaaggt cactggcaag gactaccttt
    42661 cgggacatct cactctattg agacagtaga aggaagcgtg gtggctaagc tatttgggaa
    42721 agaaagtcag gtcaactcag tccatcgtca aagcattaaa gatttggcac ctaatttccg
    42781 tgtaactgct attgattcaa gagaccaaac tattgaagcg attgagtcta tcgacgagca
    42841 ccgcattatc ggtttacagt ggcatccaga gtttctggtt aatgaagaag atggcaattt
    42901 agaattattt gagtatttat tgaatgaact gtaacgattg gaacatctgg tcgttctttc
    42961 ttttattttt tcaaaatttt tagaatgtgg cattttacgc aaacgtttga attctgataa
    43021 aaattggaga aattcgacaa aaaaacttga aaaaaacgaa ggtaagcgtt atgatagaaa
    43081 agaagaaata ttggaggaag aacatgtcac atattaaatt tgattactca aaagttttag
    43141 acaaatttgt tgcaccacat gaagtggaat acatgcaatc acaagtaaca gcagcagatg
    43201 aattgatccg taaaggaact ggtgctggta gcgacttctt gggatggttg gaccttcctg
    43261 aaaaatacga ccgcgaagaa tttgaccgca tcttgaaagc tgctgagcaa atcaagtcag
    43321 acagcgatgt tttggttgtg atcggtattg gtggatctta ccttggtgca aaagcagcaa
    43381 tcgacttctt gaatcaccat tttgctaact tgcaaacaaa agaagaacgc aaagctccac
    43441 aaatccttta cgcaggaaac tcaatctcat ctacttacct tgctgacttg gtagagtatg
    43501 ttgcagacaa agacttctca gtaaacgtaa tttctaaatc aggtacaaca actgaaccag
    43561 cgattgcttt ccgtgtcttt aaagaactct tgattaagaa atacggtcaa gaagaagcta
    43621 acaaacgtat ctatgcaaca actgaccgcc aaaagggtgc tgttaaggtt gaagcagacg
    43681 ctaacggttg gggaacattt gttgttccag atgatatcgg tggacgcttc tcagtattga
    43741 cagccgttgg tttgcttcca atcgcagcat caggagctga cataaaagct cttatggaag
    43801 gtgcgaatgc agctcgcaaa gactacactt cagacaaaat ctctgaaaac gaagcttacc
    43861 aatacgcagc tgttcgtaac atcctttatc gtaaaggcta tgcaactgag atcttggtaa
    43921 actatgagcc atcacttcaa tacttctcag aatggtggaa acaattggct ggtgaatcag
    43981 aaggaaaaga ccaaaaaggt atctacccaa cttcagccaa cttctcaact gacttgcact
    44041 cacttggtca atttatccaa gaaggaactc gtatcatgtt tgaaacagtt gtccgtgttg
    44101 acaaacctcg taaaaacgtg cttattccta ctttggaaga agaccttgac ggacttggtt
    44161 accttcaagg aaaagacgtt gactttgtaa acaaaaaagc aactgacggt gttcttcttg
    44221 cccacacaga tggtgatgta ccaaacatgt atgtgactct tccagagcaa gacgctttca
    44281 ctcttggtta cactatctac ttcttcgaat tggcaattgc cctttcaggt tacttgaatg
    44341 ctatcaaccc atttgaccaa ccaggtgttg aagcttataa acgtaacatg tttgcccttc
    44401 ttggaaaacc aggatttgaa gaattgagca aagaacttaa cgcacgtcta taatagaaga
    44461 aaagagtggt ttgcccactc tttttactct ctttatccat agaaattgga ctcagccaag
    44521 acttgtgata taatatagaa agcaaaaagg cagacgccta gataatagga gaaactatgt
    44581 caaaagatat ccgcgtacgt tacgcaccaa gtccaacagg actactacac atcggaaatg
    44641 cccgtacagc attgtttaac tacttgtatg cgcgccatca tggtggaaca tttctcatcc
    44701 gtatcgaaga tactgaccgt aaacgccatg tcgaggatgg tgaacgttca caacttgaaa
    44761 accttcgctg gttaggcatg gattgggatg aaagtccaga atcacatgag aattatcgcc
    44821 agtctgagcg tttggacttg tatcaaaaat acattgacca actattagct gaaggaaaag
    44881 cctataaatc ttacgttaca gaagaagagt tggcagctga acgtgaacgt caagaagctg
    44941 ctggtgaaac acctcgatat atcaacgaat accttggtat gagtgaagag gaaaaagcgg
    45001 cttatatcgc agaacgtgaa gcagctggta tcataccaac agttcgtttg gctgtcaatg
    45061 agtcaggtat ctacaagtgg catgatatgg tcaaaggtga tatcgaattt gaaggtggca
    45121 atatcggcgg tgactgggtt atccaaaaga aagacggtta cccaacttac aactttgccg
    45181 ttgttatcga tgaccacgat atgcaaatct ctcatgttat ccgtggagat gaccatattg
    45241 ctaatacacc aaaacagctt atggtctatg aagctcttgg ttgggaagct ccagagtttg
    45301 gtcacatgac cttgattatc aactctgaga ctggtaagaa gttatctaaa cgtgatacta
    45361 atacacttca atttatcgaa gattaccgaa agaaaggtta ccttccagaa gcagtcttta
    45421 actttattgc tcttcttggt tggaacccag gtggtgaaga tgagattttc tctcgtgaag
    45481 aactcattaa actttttgat gaaaaccgcc tcagcaagtc accagcagcc tttgatcaga
    45541 aaaaattaga ctggatgagc aatgattata tcaagaatgc agaccttgaa accatctttg
    45601 aaatggcaaa accattctta gaggaagcag gccgtttgac tgacaaggct gaaaaattag
    45661 ttgagctcta taaaccacaa atgaaatcag tagatgagat tatcccattg acagatcttt
    45721 tcttctcaga tttcccagaa ttgacagaag cagagcgcga agtcatgacg ggtgaaacag
    45781 ttccaacagt tcttgaagca ttcaaagcaa aacttgaagc gatgacagat gatgaatttg
    45841 tgacagaaaa tatcttccca caaattaaag cagtccaaaa agaaacaggt attaaaggga
    45901 aaaatctttt catgcctatt cgtatcgcag tttcaggcga aatgcatggg ccagaattac
    45961 cagatacaat tttcttgctt ggacgtgaaa aatcaattca gcatatcgaa aacattctaa
    46021 aagaaatctc taaataaaga ggatacaata atggacatct gggaaaagat gtacgaagaa
    46081 gcacagaaac tatacaatcc acatgaagta tcagactttg tttatgccaa tcatgttgta
    46141 gctgcagtag aagcaggaga tggacaaata tttacaggat tctgtatgga gggaacctgt
    46201 ggtgttttcc atctctgcgc agaacgggcg gccctcttca atatgtacca attttcagga
    46261 caaactaagg ttaagaaagt attagccttt cgagataaac caccttatgg tggaagttca
    46321 gccatgcctt gcggtgcttg tagagaattc cttttagagc ttaatgctga aaataaagat
    46381 gcagaattca tgatggacta taatataaga aaaacagtta aagtctcaga actaatccct
    46441 tattggtggg gagaagaacg tgcttctaag tttaatgagc gatagaagag tcagtataat
    46501 tctggctctt tttactataa attgaaaaaa taaaaaaaat tagaaaaagt agttgacaaa
    46561 gtttgaaaag
//
LOCUS       DAVHSO010000008        43626 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.008, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000008 DAVHSO010000000
VERSION     DAVHSO010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 43626)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43626)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43626
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.008"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(465..557)
                     /locus_tag="VVR18_000441"
     CDS             complement(465..557)
                     /locus_tag="VVR18_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="HEU6032029.1"
                     /translation="MMELVLKTIIGPIVVGVVLRIVDKWLNKDK"
     gene            718..1689
                     /gene="ruvB"
                     /locus_tag="VVR18_000442"
     CDS             718..1689
                     /gene="ruvB"
                     /locus_tag="VVR18_000442"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HEU6032030.1"
                     /translation="MGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALD
                     HVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDE
                     IHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLR
                     ARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRV
                     RDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSV
                     NIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK"
     gene            1670..2242
                     /locus_tag="VVR18_000443"
     CDS             1670..2242
                     /locus_tag="VVR18_000443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001098890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase family protein"
                     /protein_id="HEU6032031.1"
                     /translation="MNTVKNKQEILEAFRENPDMMAILTIIRDLGLKDSWLAAGSVRN
                     FIWNLLSDKSPFDHETDIDVIFFDPDFSYEETLLLEKKLREDFPQYQWELKNQVYMHQ
                     HSPHTASYTSSRDAMSKYPERCTTVGLRLNEESDFELYAPYGLEDILNFQVRPTPHFL
                     ENEDRMELYQTRLSKKNWQEKWKNLIFKNT"
     gene            2473..3231
                     /locus_tag="VVR18_000444"
     CDS             2473..3231
                     /locus_tag="VVR18_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HEU6032032.1"
                     /translation="MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFG
                     HKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPEL
                     HANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
                     SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYS
                     ELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV"
     gene            3240..4043
                     /locus_tag="VVR18_000445"
     CDS             3240..4043
                     /locus_tag="VVR18_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HEU6032033.1"
                     /translation="MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIIAMLAMHE
                     LLKMRGLETMTMEGLLTLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTVFS
                     KSYTIEDAVFPLAMSFYVGFGFNALLDARVAGLDKALLALCIVWATDSGAYLVGMNYG
                     KRKLAPRVSPNKTLEGALGGILGAILVTIIFMIVDSTVALPYGIYKMSVFAIFFSIAG
                     QFGDLLESSIKRHFGVKDSGKFIPGHGGVLDRFDSMLLVFPIMHLFGLF"
     gene            4065..5324
                     /gene="rseP"
                     /locus_tag="VVR18_000446"
     CDS             4065..5324
                     /gene="rseP"
                     /locus_tag="VVR18_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HEU6032034.1"
                     /translation="MLGILTFILVFGIIVVVHEFGHFYFAKKSGILVREFAIGMGPKI
                     FAHIGKDGTAYTIRILPLGGYVRMAGWGDDTTEIKTGTPVSLTLADDGKVKRINLSGK
                     KLDQTALPMQVTQFDFEDKLFIKGLVLEEEKTFAVDHDATVVEADGTEVRIAPLDVQY
                     QNATIWGKLITNFAGPMNNFILGVVVFWVLIFMQGGVRDVDTNQFHIMPQGALAKVGV
                     PETAQITKIGSHEVSNWESLIQAVETETKDKTAPTLDVTISEKGSDKQVTVTPEDSQG
                     RYLLGVQPGVKSDFLSMFVGGFTTAADSALRILSALKNLIFQPDLNKLGGPVAIFKAS
                     SDAAKNGIENILYFLAMISINIGIFNLIPIPALDGGKIVLNILEAIRRKPLKQEIETY
                     VTLAGVVIMVVLMIAVTWNDIMRLFFR"
     gene            5337..7190
                     /locus_tag="VVR18_000447"
     CDS             5337..7190
                     /locus_tag="VVR18_000447"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HEU6032035.1"
                     /translation="MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLP
                     LANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKS
                     DFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDA
                     YSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSART
                     DLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATN
                     EYKPSNRVIAEEEVIRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVG
                     NDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVR
                     NAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFK
                     LGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRY
                     AWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKF
                     SDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK"
     gene            7289..8668
                     /gene="bglA"
                     /locus_tag="VVR18_000448"
     CDS             7289..8668
                     /gene="bglA"
                     /locus_tag="VVR18_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000943526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HEU6032036.1"
                     /translation="MLRFPKDFVWGSSTSGPQTEGRVAGDGKGDNLWDYWFQVEPNRY
                     YNGIGSDKTSTFYENWERDIELLLETGHTAFRTSIQWSRIFPQGCGKVNTQGVDFYRK
                     VFEAIKAKGIRLLVNLYHFDLPFALQEDGDGWENKATVSAYEDYARFCFETYGDLVDQ
                     WITFNEPIVPVEFGYFYDAHYPHKVDAEAAVKVAYHTQLASSRAVKACHELLPDSKIG
                     IVLNLTPAYPRSQHPADVKAARIAALFQAQSFLDPSVLGTYPQELVEILHEHGLLPDA
                     TEEELELIRDNTVDFLGVNYYQPLRVMAPRFAKHPESPLLPEHFYEPYVMPGRKINSH
                     RGWEIYEQGIYDIAQNIKENYGNIEWMLTENGMGVEGEEKFRQDGMIQDDYRIDFVKG
                     HLRELHRAIEDGANCKGYLIWTFIDCWSWLNSYKNRYGLVELDLETQERRLKKSGHWF
                     KELSDNNGF"
     gene            8861..10669
                     /gene="glmS"
                     /locus_tag="VVR18_000449"
     CDS             8861..10669
                     /gene="glmS"
                     /locus_tag="VVR18_000449"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HEU6032037.1"
                     /translation="MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHL
                     VKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIE
                     NYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
                     VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADS
                     VEVQDYDGNRRERASYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQ
                     VVVDPDIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPL
                     LSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGP
                     EIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQAFDLIHELSIVAQSIESTLSEKET
                     IEAKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALI
                     EEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTTVHPYLS
                     PISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE"
     gene            10788..11837
                     /locus_tag="VVR18_000450"
     CDS             10788..11837
                     /locus_tag="VVR18_000450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HEU6032038.1"
                     /translation="MVELGISTFGEITELEGTGQTYSHAERIRQLVAEIELADKVGLD
                     VYGIGEHHRADFAVSAPEIVLAAGAVNTKKIRLTSAVSILSSMDPIRLFQQYATIDAL
                     SNGRAEIMAGRGSFTESFPLFGYDLKDYDSLFDEKLDLLQLVNEKTKLDWQGRLTQTI
                     AGKEVYPRPVQDKLPLWIATGGHVESTVKIAQAGLPIVYAIIGGNPRYFKKLIQAYRE
                     IGSEAGHADKDLKVGAHSWGWIAEDGEQAVKDYFHPTKQVVDAISKDRPHWQELRYEQ
                     YLEQVGSNGAMFVGNPDQVAEKLIRMIEDLGLDRFMLHLPLGSMPHDQVLRAIELFGT
                     QVAPKVRAYFAMKEA"
     gene            complement(11937..15779)
                     /gene="spuA"
                     /locus_tag="VVR18_000451"
     CDS             complement(11937..15779)
                     /gene="spuA"
                     /locus_tag="VVR18_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored pullulanase SpuA"
                     /protein_id="HEU6032039.1"
                     /translation="MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISS
                     DESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPRNANASLEKTEEKPAASPA
                     DSAPQTGQDRSSEPTTSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDD
                     VEKPSENWPNGALSFKDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVE
                     KLVPKMNEAWLDQDYKVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQW
                     PDGTDFTATGKYGRYIDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQ
                     IFLKDDDESIYTNPYYVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHL
                     GNKVTITDVAIDEAGKKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGK
                     LGADLKEEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDST
                     NKLGITDFTGYYYQYQIERQGKTVLALDPYAKSLAAWNSDDAKIDDAHKVAKAAFVDP
                     AKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDY
                     LKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSD
                     PKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDIFEDLEPNYYHFMDADGTPR
                     TSFGGGRLGTTHHMTKRLLVDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARAL
                     NPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPA
                     FITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKA
                     ENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHL
                     LRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQS
                     TDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKARE
                     FNLGTAFAHLRNAEVLADENQAGSVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTS
                     HESTAEEKPDSTPSKPEHQNEASHPAHQDPAPEARPDSTKPDAKVADAENKPSQATAD
                     SQAEQPAQEAQASSVKEAVRKESVENSSKENISATPDRQAELPNTGIKNENKLLFAGI
                     SLLALLGLGFLLKNKKEN"
     gene            16196..16609
                     /gene="rpsL"
                     /locus_tag="VVR18_000452"
     CDS             16196..16609
                     /gene="rpsL"
                     /locus_tag="VVR18_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002356190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HEU6032040.1"
                     /translation="MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKR
                     GVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKD
                     LPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA"
     gene            16629..17099
                     /gene="rpsG"
                     /locus_tag="VVR18_000453"
     CDS             16629..17099
                     /gene="rpsG"
                     /locus_tag="VVR18_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HEU6032041.1"
                     /translation="MSRKNRAPKRDVLPDPLYNSQLVTRLINRVMLDGKRGTAASIVY
                     GAFEQIKEATGNDALEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLR
                     WLVTIARLRGEHTMQDRLAKEILDAANNTGAAVKKREDTHRMAEANRAFAHFRW"
     gene            17524..19605
                     /gene="fusA"
                     /locus_tag="VVR18_000454"
     CDS             17524..19605
                     /gene="fusA"
                     /locus_tag="VVR18_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HEU6032042.1"
                     /translation="MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETH
                     EGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGA
                     VTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAH
                     PIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLIEAV
                     AETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVID
                     YLPSPLDIPAIKGINPDTDAEEIRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVL
                     QSGSYVLNTSKGKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEK
                     AKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVIS
                     GMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDV
                     WIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLY
                     DGSYHDVDSSETAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTA
                     RRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQ
                     EEIIKKNKGED"
     gene            19709..24100
                     /locus_tag="VVR18_000455"
     CDS             19709..24100
                     /locus_tag="VVR18_000455"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HEU6032043.1"
                     /translation="MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFH
                     FVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGP
                     CASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQ
                     VEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKA
                     AAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSM
                     QKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPE
                     GERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKA
                     GIQLIYGMEANIVEDRVPIVYNEVEMDLSEAIYVVFDVETTGLSAIYNDLIQVAASKM
                     YKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVA
                     HNATFDVGFMNANYERHDLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEH
                     HHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKN
                     QVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVD
                     AAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGN
                     VHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFL
                     GEELARKLVIENTNALAEIFEPVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPL
                     PDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGI
                     TEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIPFETFLG
                     FDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERD
                     YGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQ
                     TTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVL
                     GVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQD
                     LIKQGIVDLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIE
                     AMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAK
                     AFDIKTMGAGLEVIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLD
                     LYCSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSST
                     LVEKMDEMGILGNMPEDNQLSLFDELF"
     gene            24202..24465
                     /locus_tag="VVR18_000456"
     CDS             24202..24465
                     /locus_tag="VVR18_000456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="HEU6032044.1"
                     /translation="MSKMSISIRLDSEVKEQAQQVFSNLGMDMTTAINIFLRQAIQYQ
                     GLPFDVRLDENRKLLQALTDLDQNRNMSQSFESVSDLMEDLRA"
     gene            24509..24736
                     /locus_tag="VVR18_000457"
     CDS             24509..24736
                     /locus_tag="VVR18_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001822121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system mRNA interferase
                     toxin, RelE/StbE family"
                     /protein_id="HEU6032045.1"
                     /translation="MKRGLKAELLEEVLNFLVQEKEHPARYRDHSLTASKHFQGVREC
                     YTQPDWLLVYKVDKSELILNLLRTGSHSDLF"
     gene            24757..24909
                     /locus_tag="VVR18_000458"
     CDS             24757..24909
                     /locus_tag="VVR18_000458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032046.1"
                     /translation="MKLRIFAEDKPAKKVFEYQLELADRTILLSTALLSGAIALAGIF
                     SALKEK"
     gene            24931..26073
                     /locus_tag="VVR18_000459"
     CDS             24931..26073
                     /locus_tag="VVR18_000459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HEU6032047.1"
                     /translation="MVLPNFKENLEKYAKLLVANGINVQPGHTLALSIDVEQRELAHL
                     IVKEAYALGAHEVIVQWTDDVINREKFLHAPMERLDNVPEYKIAEMNYLLENKASRLG
                     VRSSDPGALNGVDADKLSASAKAMGLAMKPMRIATQSNKVSWTVAAAAGLEWAKKVFP
                     NAASDEEAVDLLWDQIFKTCRVYEADPVKAWEEHAAILKSKADMLNKEQFSALHYTAP
                     GTDLTLGLPKNHVWESAGAVNAQGEGFLPNMPTEEVFTAPDFRRADGYVTSTKPLSYN
                     GNIIEGIKVTFKDGQIVDITAEKGDQVMKDLVFENASNHLAIGAAYATSVVDGAEMSE
                     EELEAAGLNRSDVHVDFMIGSNQMDIDGIREDGTRVPLFRNGNWAN"
     gene            26083..26313
                     /locus_tag="VVR18_000460"
     CDS             26083..26313
                     /locus_tag="VVR18_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000901571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEU6032048.1"
                     /translation="MLGSMFVGLLVGFLAGAMTNRGERMGCFGKMFLGWIGAFLGHLL
                     FGTWGPVLSGTAIIPAILGAMIVLAIFWRRGS"
     gene            26334..26411
                     /locus_tag="VVR18_000461"
                     /pseudo
     CDS             26334..26411
                     /locus_tag="VVR18_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            26581..27303
                     /locus_tag="VVR18_000462"
     CDS             26581..27303
                     /locus_tag="VVR18_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEU6032049.1"
                     /translation="MRLDKFLVACAVGSRTEVKNLLKAGRVTVNGKKEKSAKLQIDEK
                     IDEIRFDGQVLEYEEFVYYMMNKPKGVISATEDPKHRTVLDLLDDLARSKEVFPVGRL
                     DIDTHGLLLLTNDGQLAHVLLSPKRHVDKTYLAQVKGIMTQEDVETFAEGIPLKDFTC
                     QPAILELVSIDTEKNQSQIRVTIAEGKFHQIKRMVGYCGKEVVDLQRLTMGTLVLDEN
                     LERGEWRRLTKEELEILRANII"
     gene            27520..28854
                     /gene="pepC"
                     /locus_tag="VVR18_000463"
     CDS             27520..28854
                     /gene="pepC"
                     /locus_tag="VVR18_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000991632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase C"
                     /protein_id="HEU6032050.1"
                     /translation="MNAIQESFTDKLFANYEANVKYQAIENAASHNGIFAALERRQSH
                     VDNTPVFSLDLTKDKVTNQKASGRCWMFAALNTFRHKLISQYKLENFELSQAHTFFWD
                     KYEKSNWFLEQVIATSDQELTSRKVSFLLQTPQQDGGQWDMVVSLFEKYGVVPKSVYP
                     ESVSSSSSRELNAILNKLLRQDAQILRDLLVSGADQATVQAKKEDLLQEIFNFLAMSL
                     GLPPRKFDFAYRDKDNNYKSEKGITPQEFYKKYVNLPLEDYVSVINAPTADKPYGKSY
                     TVEMLGNVVGSRAVRYINVPMERLKELAIAQMQAGETVWFGSDVGQLSNRKAGILATD
                     VYDFESSMDIKLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKSTKWKVENSWGDKVG
                     TDGYFVASDAWMDEYTYQIVVRKELLTAEEQAAYGAEPIVLAPWDPMGALAE"
     gene            complement(28910..29821)
                     /locus_tag="VVR18_000464"
     CDS             complement(28910..29821)
                     /locus_tag="VVR18_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU6032051.1"
                     /translation="MTEKLQLTKSDRKKVWWRSTFLQGSWNFERMQNLGWAYTLIPAI
                     KKLYTKKEDQIAALERHLEFFNTHPYVAAPVMGVTLALEEERANGVEIDDAAIQGVKI
                     GMMGPLAGIGDPVFWFTVRPILGSLGASLALTGNILGPLLFFVAWNLIRMSFLWYVQE
                     IGYKAGSEITKDMSGGILQDITKGASILGMFILAVLVQRWVNIKFAFDVSKVQLDEKA
                     YIHWDKLPEGSKGIQEAFAQVGQGLSQTPEKVTTFQQNLDMLIPGLSGLLLTLLCMYL
                     LKKKVSPITIILALFAVGIVAHVLHIM"
     gene            complement(29845..30648)
                     /locus_tag="VVR18_000465"
     CDS             complement(29845..30648)
                     /locus_tag="VVR18_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter subunit
                     IIC"
                     /protein_id="HEU6032052.1"
                     /translation="MSIISMVLVVVVAFFAGLEGILDQFQFHQPLVACTLIGLVTGHL
                     EAGIILGGSLQMIALGWSNIGAAIAPDAALASVAAAIIMVLGGDFTKTGIGVAQAVAI
                     PLAVAGLFLTMIVRTISVGLVHTADAAAKKGDFGAVERAHFIALLFQGLRIALPAALL
                     LMVPTETVQSILSAMPDWLKDGMAIGGGMVVAVGYAMVINMMATREVWPFFALGFVLA
                     AVSDITLIGFGAIGVAIALIYLHLSKTGGNGGGGAATSNDPIGDILEDY"
     gene            complement(30676..31665)
                     /gene="manX"
                     /locus_tag="VVR18_000466"
     CDS             complement(30676..31665)
                     /gene="manX"
                     /locus_tag="VVR18_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIAB"
                     /protein_id="HEU6032053.1"
                     /translation="MSIGIIIASHGEFAAGIHQSGSMIFGEQEKVQVVTFMPNEGPDD
                     LYAKFNNAVAAFDAEDEVLVLADLWSGSPFNQASRVMGENPERKFAIITGLNLPMLIQ
                     AYTERLMDAAAGVEKVAANIIKEAKDGIKALPEELNPVEEVASAAAAPVAQTAIPEGT
                     VIGDGKLKINLARLDTRLLHGQVATAWTPDSKANRIIVASDNVAKDDLRKELIKQAAP
                     GNVKANVVPIQKLIEISKDPRFGETHALILFETPQDALRAIEGGVPIKTLNVGSMAHS
                     TGKTLVNTVLSMDKEDVATFEKMRDLGVEFDVRKVPNDSKKDLFDLINKANVK"
     gene            complement(31900..32919)
                     /gene="adhP"
                     /locus_tag="VVR18_000467"
     CDS             complement(31900..32919)
                     /gene="adhP"
                     /locus_tag="VVR18_000467"
                     /EC_number="1.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="HEU6032054.1"
                     /translation="MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHV
                     AHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRET
                     LCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
                     EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVE
                     DVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTV
                     LDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMV
                     LDFTH"
     gene            complement(33261..34073)
                     /locus_tag="VVR18_000468"
     CDS             complement(33261..34073)
                     /locus_tag="VVR18_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU6032055.1"
                     /translation="MTKKIIAVDLDGTLLNSDSQISDFTKRTIKKVAEKGHQVIITTG
                     RPYRMSKDFYRELGLDTPMINFNGSLTHLPDQVWDFEKCLTVDKKYLLDMVQRSEDIQ
                     ADFIAGEYRKKFYITNPNEEIANPKLFGVEAFQPEDQFQPELVTKDPNCILLQTRASD
                     KYALAKEMNAFYQHQLSINTWGGPLNILECTPKGVNKAFALDYLLKIMNRDKKDLIAF
                     GDEHNDTEMLAFAGKGYAMKNANPELLPYADEQISLTNDQDGVAKTLQDLFL"
     gene            34263..35681
                     /locus_tag="VVR18_000469"
     CDS             34263..35681
                     /locus_tag="VVR18_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HEU6032056.1"
                     /translation="MDKLFKLKENGTDVRTEVLAGLTTFFAMSYILFVNPQILSQTGM
                     PAQGVFLATIIGAVAGTLMMAFYANLPYAQAPGMGLNAFFTFTVVFGLGYSWQEALAM
                     VFICGIISLIITLTNVRKMIIESIPNALRSAISAGIGVFLAYVGIKNAGLLKFTIDPG
                     NYTVVGEGADKAQATIAANSSAVPGLVSFNNPAVLVALAGLAITIFFVIKGIKGGIIL
                     SILTTTVLAIAVGLVDLSSIDFANNHVGAAFEDLKTIFGAALGSEGLGALVSDTARLP
                     ETLMAILAFSLTDIFDTIGTLIGTGEKVGIVATNGENHQSAKLDKALYSDLIGTTVGA
                     IAGTSNVTTYVESAAGIGAGGRTGLTALVVAICFAISSFFSPLLAIVPTAATAPILII
                     VGIMMLGSLKNIHWDDMSEAVPAFFTSIFMGFSYSITQGIAVGFLTYTLTKLVKGQVK
                     DVHAMIWILDALFILNYISMAL"
     gene            35735..36442
                     /locus_tag="VVR18_000470"
     CDS             35735..36442
                     /locus_tag="VVR18_000470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6032057.1"
                     /translation="MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVAL
                     LQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFFRAKDLARLGLSYLVIVGSNILGS
                     ILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIIPKKIFRGKE
                     NLGFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAF
                     CLLALVVIMSRTLGISV"
     gene            36537..37511
                     /gene="folP"
                     /locus_tag="VVR18_000471"
     CDS             36537..37511
                     /gene="folP"
                     /locus_tag="VVR18_000471"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HEU6032058.1"
                     /translation="MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQ
                     ALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDT
                     WKSQVAEAALAAGADLVNDITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLI
                     FPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGL
                     TKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTAS
                     AHVTSIAARQCVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK"
     gene            37513..38835
                     /locus_tag="VVR18_000472"
     CDS             37513..38835
                     /locus_tag="VVR18_000472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEU6032059.1"
                     /translation="MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVLHI
                     GGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMADY
                     QSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILT
                     GITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALAVIDRIAEGKDAPR
                     LAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQE
                     DGRELASNDFLGQALEETSWPGRLEIVSRDPLMILDGAHNPHAIKALLVTLQERFADY
                     HKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATDESVLKEAAKSRNLSYQD
                     WHDFLEQNVTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENGYTKD"
     gene            38816..39370
                     /gene="folE"
                     /locus_tag="VVR18_000473"
     CDS             38816..39370
                     /gene="folE"
                     /locus_tag="VVR18_000473"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HEU6032060.1"
                     /translation="MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGL
                     GQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKL
                     ARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPGTATL
                     TTVARGLFETDKDLRDQAYRLMGL"
     gene            39413..40225
                     /gene="folK"
                     /locus_tag="VVR18_000474"
     CDS             39413..40225
                     /gene="folK"
                     /locus_tag="VVR18_000474"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HEU6032061.1"
                     /translation="MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATD
                     LDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWA
                     PVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
                     EPWGGVEQDSFTNQVVEVETWLPAQVLLETLLAIESELGRVREVHWGPRLIDLDLLFV
                     EDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALKK"
     gene            complement(40270..40587)
                     /locus_tag="VVR18_000475"
     CDS             complement(40270..40587)
                     /locus_tag="VVR18_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF960 domain-containing protein"
                     /protein_id="HEU6032062.1"
                     /translation="MAFTNTHMRSASFGIVTSLPDDIIDSFWYIIDHFLKNVFELEEE
                     FEFQLLNNQGKITFHFSSQHLPTAIDFDFNHPFDPRYPPRVLVLDMDGRETILLPEEN
                     DLF"
     gene            40943..41389
                     /gene="rplM"
                     /locus_tag="VVR18_000476"
     CDS             40943..41389
                     /gene="rplM"
                     /locus_tag="VVR18_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HEU6032063.1"
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKP
                     TFTPHTDTGDFVIVINAEKVKLTGKKATDKIYYTHSNHPGGLKQISAGELRSKNAVRL
                     IEKSVKGMLPHNTLGRAQGMKLKVFVGAEHTHAAQQPEVLDISGLI"
     gene            41408..41800
                     /gene="rpsI"
                     /locus_tag="VVR18_000477"
     CDS             41408..41800
                     /gene="rpsI"
                     /locus_tag="VVR18_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HEU6032064.1"
                     /translation="MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADL
                     RLVINQPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAG
                     LLTRDSRKVERKKPGLKKARKASQFSKR"
     gene            complement(42063..43241)
                     /locus_tag="VVR18_000478"
                     /pseudo
     CDS             complement(42063..43241)
                     /locus_tag="VVR18_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014678337.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
     gene            complement(43204..43626)
                     /locus_tag="VVR18_000479"
                     /pseudo
     CDS             complement(43204..43626)
                     /locus_tag="VVR18_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000476106.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsK"
BASE COUNT        12413 a         8396 c        10023 g        12794 t
ORIGIN      
        1 aggcttttgg ggactattct aaaaataatt tttcgatatt tttcggtatt tttcggattt
       61 tggtcgggga attggcgggg acttttttag cgaatataac taagaaatag gtctgtggtc
      121 gcttcagcta gttcaaactc aatttgattg taagtgactg ttaattgaag aactggaact
      181 actgtaataa tgattttgct tgtctagtag tggcgtatta aatgagaagt gacatgtaag
      241 attgtcgctt cgtttacgaa atcaaaattt ctatgaaatt gatagaatcc ctaacgttct
      301 cttaatctta accgtcttgt cgtacagcgg ttgaagaaaa tgtaaacctt tgacaaaatt
      361 cgtgaactat gggataataa aaaggaattg agtactagtt ctatatcata ggctagaaaa
      421 gaccccaagc tcacgaccaa ataagcttga ggtctttttt gacactattt gtccttgttt
      481 agccatttat cgactatacg aagaacgaca ccgaccacaa ttggtccgat gatagttttg
      541 agtactaatt ccatcatggg ctatctcacc tcctttcgta ggcggtgtag cagtgtcgta
      601 gaatattata ccacataagt gctaaactta ggagtcaccc aatcaggtgg cttttttgtt
      661 tgtggcttgg ttttttgata taatagagcc atgagtagaa ttttagataa tgagataatg
      721 ggggatgagg agttagtaga acgcacgctc cgtcctcagt atttacgtga atatatcgga
      781 caggataagg tcaaggacca gctacaaatc tttattgaag ctgccaaaat gcgggatgaa
      841 gcgctggatc atgtgctctt atttgggcct ccaggtctcg ggaaaacgac catggccttt
      901 gttattgcca acgaactggg agtcaatctt aagcagacgt cgggtccagt cattgaaaaa
      961 gccggagatc tggtagctat tttgaatgag ttagagcctg gggatgtcct ttttattgat
     1021 gagatccatc gtttgccaat gtcagtggaa gaggtgcttt atagtgctat ggaggacttc
     1081 tacatagata ttatgattgg ggctggtgag ggtagtcgta gtgttcattt ggagttacca
     1141 ccttttacct tgattggtgc gacgactcgg gctggtatgc tctccaatcc gctacgggca
     1201 cgttttggga ttacaggcca tatggagtat tatgcccatg ctgacttgac agaaattgtc
     1261 gagcggacgg cagatatttt tgagatggaa atcactcatg aggcagcatc tgagttggcc
     1321 ctacgtagtc gtgggacccc tcgtattgcc aatcgtctcc tcaagcgcgt gcgcgatttt
     1381 gcccagataa tggggaatgg ggtaattgat gatattatta ccgataaggc tttgactatg
     1441 ctggatgttg accatgaagg tttggactat gtggatcaaa aaatccttcg taccatgatt
     1501 gagatgtaca gtggaggacc tgttggtcta ggaactcttt ctgtgaatat cgccgaagag
     1561 cgtgagacag ttgaagatat gtatgagcct tacttgattc aaaaaggttt tatcatgcgg
     1621 acacggtctg gacgggtggc gactgctaag gcatatgagc acttaggtta tgaatacagt
     1681 gaaaaataag caagaaatct tagaggcttt tagagaaaat ccagatatga tggccattct
     1741 gacgatcatc cgagaccttg gtctgaaaga ctcgtggttg gcagcaggtt ctgtcagaaa
     1801 tttcatttgg aatcttttgt cagacaaatc cccttttgat catgaaacag atatagatgt
     1861 gattttcttt gatccagatt tttcttatga ggaaacctta ttactggaga aaaagctgcg
     1921 agaggatttt cctcagtacc agtgggaatt gaaaaatcag gtctatatgc atcagcacag
     1981 tcctcacact gcttcctata ccagttctcg tgatgctatg agtaagtatc cagaacggtg
     2041 tacgacagtt ggactgcgct tgaatgaaga atcagatttt gaactctatg caccttatgg
     2101 tttggaggat attttgaatt ttcaagttcg tccaactcct catttcttag aaaatgaaga
     2161 ccgaatggaa ctctatcaaa cacgtttatc caagaaaaat tggcaggaga aatggaaaaa
     2221 tttgattttt aaaaatactt aaggaaactt taagctaggg agtgtacact aagttcataa
     2281 gttaagaaga ccttaactta aactcctaaa actttttcat aataatctcc ctataaaaat
     2341 aaagtcgccc aatcaggcgg cttatttttt tgaaaaatgg gcttggtgcc tgagaataaa
     2401 tagcttagtg atagaagaaa atggggaaat atggtataat aaaacgatag atttttgaat
     2461 aggaataaga tcatgtttgg attttttaag aaagataagg ctgtggaagt agaggttccg
     2521 acacaggttc ctgctcatat cggcatcatc atggatggca atggccgttg ggctaaaaaa
     2581 cgtatgcaac cgcgagtttt tggacataag gcgggcatgg aagcattgca aaccgtgacc
     2641 aaggcagcca acaaactggg cgtcaaggtt attacggtct atgctttttc tacggaaaac
     2701 tggacccgtc cagatcagga agtcaagttt atcatgaact tgccagtaga gttttatgat
     2761 aattatgtcc cggaactaca tgcgaataat gttaagattc aaatgattgg ggagacagac
     2821 cgcctgccta agcaaacctt tgaagcttta accaaggctg aggaattgac taagaacaac
     2881 acaggattga ttcttaattt tgctcttaac tatggtggac gtgctgagat tacacaggcg
     2941 cttaagttga tttcccagga tgttttagat gccaaaatca atccaggtga catcacagag
     3001 gaattgattg gcaactatct ctttacccag catttgccta aggacttacg agacccagac
     3061 ttgattatcc gtactagtgg agaattgcgt ttgagcaatt tccttccatg gcagggagcc
     3121 tatagtgagc tttattttac ggacacctta tggcctgatt ttgacgaagc ggccttgcag
     3181 gaagctattc ttgcctataa tcgtcgtcat cgccgatttg gaggagttta ggaggaaata
     3241 tgacccagga tttacagaaa agaaccttgt ttgcagggat tgccctggct attttcctac
     3301 caattttaat gattgggggc ctcttgcttc agatagcaat cggaatcata gctatgctag
     3361 ccatgcatga acttttgaag atgagaggtc tagagaccat gacgatggag ggcctcttga
     3421 ccctctttgc aacctttgca ttgaccattc ccttggagaa ttacctgact tttttgccag
     3481 ttgatgggaa tgtggttgcc tatagtgttt tgatttcaat catgttagga acgaccgttt
     3541 ttagcaagtc ttatacgatt gaggatgcgg ttttccctct tgctatgagc ttctacgtgg
     3601 gctttggatt taatgcttta ctagatgctc gtgttgcagg tttggacaag gctctcttag
     3661 ccttgtgtat cgtctgggcg acagacagtg gtgcctatct tgttgggatg aactatggga
     3721 aacgaaagtt agcaccaagg gtatcgccta ataaaaccct tgagggtgcc ttgggtggta
     3781 ttttaggagc aattttagta accattatct ttatgatagt tgacagtaca gttgctcttc
     3841 catatggaat ttacaagatg tcagtctttg ctattttctt tagcattgct ggacaatttg
     3901 gtgatttact agaaagttcg atcaaacgtc attttggtgt taaggattct gggaaattta
     3961 tccctggaca tggtggtgtt ttggatcgtt tcgatagtat gttgcttgta tttccaatca
     4021 tgcacttatt tggactcttt taatcaaaag acggaggaaa cgctatgctc ggaattttaa
     4081 cctttattct ggttttcggg attattgtag tggtgcacga gttcgggcac ttctactttg
     4141 ccaagaaatc agggatttta gtacgtgaat ttgccatcgg tatgggacct aaaatttttg
     4201 ctcacattgg caaggatgga acggcctata ccattcgaat cttgcctctg ggtggctatg
     4261 tccgcatggc cggttggggt gatgatacaa ctgaaatcaa gacaggaacg cctgttagtt
     4321 tgacacttgc tgatgatggt aaggttaaac gcatcaatct ctcaggtaaa aaattggatc
     4381 aaacagccct ccctatgcag gtgacccagt ttgattttga agacaagctc tttatcaaag
     4441 gattggttct ggaagaagaa aaaacatttg cagtggatca cgatgcaacg gttgtggaag
     4501 cagatggtac tgaggttcgg attgcacctt tagatgttca atatcaaaat gcgactatct
     4561 ggggcaaact gattaccaat tttgcaggcc ctatgaacaa ttttatctta ggtgtcgttg
     4621 ttttttgggt tttaatcttt atgcagggtg gtgtcagaga tgttgatacc aatcagttcc
     4681 atatcatgcc ccaaggtgcc ttggccaagg taggagtacc agaaacggca caaattacca
     4741 agattggctc acatgaggtt agcaactggg aaagcttgat ccaagctgtg gaaacagaaa
     4801 ccaaagataa gacggcaccg actttggatg tgactatttc tgaaaagggg agtgacaaac
     4861 aagtcactgt tacacccgaa gatagtcaag gtcgttacct tctaggtgtt caaccggggg
     4921 ttaagtcaga ttttctatcc atgtttgtag gtggttttac aactgctgct gactcagctc
     4981 tccgaattct ctcagctctg aaaaatctga ttttccaacc ggatttgaac aagttgggtg
     5041 gacctgttgc tatctttaag gcaagtagcg atgctgctaa aaatggaatt gaaaatatct
     5101 tgtacttctt ggcaatgatt tccattaata ttgggatttt taatcttatt ccgattccag
     5161 ccttggatgg tggtaagatt gtgctcaata tcctagaagc catccgccgc aaaccattga
     5221 aacaagaaat tgaaacctat gtcaccttgg ccggagtggt catcatggtt gtcttgatga
     5281 ttgctgtgac ttggaatgac attatgcgac tcttttttag ataatcgagg aatattatga
     5341 aacaaagtaa aatgcctatc ccaacgcttc gcgaaatgcc aagcgatgct caagttatca
     5401 gccatgctct tatgttgcgt gctggttatg ttcgccaagt ttcagcaggt gtttattctt
     5461 atctaccact tgccaaccgt gtgattgaaa aagctaaaaa catcatgcgc caagaattcg
     5521 aaaagattgg tgctgttgag atgttggctc cagcccttct tagtgcagaa ttgtggcgtg
     5581 aatcaggtcg ttacgaaacc tatggtgaag acctttacaa actaaaaaac cgtgaaaaat
     5641 cagactttat cttaggtcca actcacgaag aaacctttac agctattgtc cgtgattctg
     5701 ttaaatctta caagcaattg ccactcaacc tttatcaaat tcagcccaag tatcgtgatg
     5761 aaaaacgccc acgtaatgga cttcttcgta cacgtgagtt tatcatgaag gatgcttata
     5821 gtttccacgc taactatgat agtttggata gtgtttatga tgagtacaaa gcagcctatg
     5881 agcgtatttt cactcgtagt ggtttagact tcaaggctat tattggtgac ggtggagcca
     5941 tgggtggtaa ggatagccaa gaatttatgg ccattacatc tgctcgtaca gaccttgacc
     6001 gctgggttgt cttggacaag tcagttgcct catttgacga aattcctgca gaagtgcaag
     6061 aagaaatcaa ggcagaattg ctcaaatgga tagtctctgg tgaagatacc attgcttact
     6121 caagtgagtc tagctatgca gctaacttag aaatggcaac aaacgagtac aaaccaagca
     6181 accgtgttat cgctgaagaa gaagttattc gtgttgcaac gccagatgtt aaatcaattg
     6241 atgaagttgc agccttcctc aatgttccag aagaacaaac gattaaaacc ctcttctaca
     6301 ttgcagatgg tgagcttgtt gcagcccttc tagttggaaa tgaccaactc aacgaagtca
     6361 agttgaaaaa tcacttggga gcagatttct ttgacgttgc tagcgaagaa gaagtggcga
     6421 atgttgttca agcaggattt ggttcacttg gaccagttgg tttgccagag aatattaaaa
     6481 ttattgcaga tcgtaaggtg caagatgttc gcaatgcagt tgtcggtgct aacgaagatg
     6541 gctaccactt gactggtgtg aacccaggcc gtgattttac tgcagaatat gtggatatcc
     6601 gtgaagttcg tgagggtgaa atttccccag atggacaagg tgtccttaac tttgcgcgtg
     6661 gtattgagat cggtcatatt ttcaaactcg gaactcgcta ttcagcaagc atgggagcag
     6721 atgtcttgga tgaaaatggt cgtgctgtgc caatcatcat gggatgttac ggtatcggtg
     6781 tcagccgtct tctttcagca gtgatggagc aacatgctcg cctctttgtt aacaaaacgc
     6841 caaaaggtga ataccgttac gcttggggaa tcaatttccc taaagaattg gcaccatttg
     6901 atgtgcattt gattactgtt aatgtcaagg atgaagaagc gcaagccttg acagaaaaac
     6961 ttgaagcaag cttgatggga gctggttatg aagtcttgac agatgaccgt aacgaacgtg
     7021 tcggtgttaa atttagcgat agtgacttga ttggtcttcc aatccgtatc actgttggta
     7081 aaaaagcggc cgatggcatt gtagaagtta agatcaaggc aactggtgac accattgagg
     7141 ttcatgcaga taacgtgctt gaaacgcttg aaatcctaag caagaaataa aaactataat
     7201 cagaagaaaa acaaggaaaa aatgtaacta gtttttacct tgttttttct gtataatggg
     7261 agaaatgagt agataaagag gtaaatgtat gctaagattt ccaaaggatt ttgtctgggg
     7321 atcctctact tctggaccgc agacagaagg acgtgtagct ggtgacggta agggagacaa
     7381 tctctgggat tactggttcc aagtggagcc aaatcgttac tataatggga ttggttcaga
     7441 taagacatcg actttttatg aaaattggga gcgggatatt gagcttttgt tagagactgg
     7501 tcacacagcc tttcggactt ctattcagtg gtcacggatt tttccacaag gctgtggaaa
     7561 agtcaacact caaggtgtgg atttttatcg taaggtcttt gaggctatta aggctaaagg
     7621 aattcgtctg ttagtcaatc tctatcattt tgatttacct tttgcccttc aagaggatgg
     7681 tgatggttgg gaaaataagg cgacagtctc agcctatgaa gactatgctc gtttttgttt
     7741 tgagacttat ggagatttag tggatcaatg gattaccttt aacgagccca tcgttcctgt
     7801 agaatttggt tatttttatg atgcccatta tccacataag gtggatgcag aggcagctgt
     7861 taaggtagcc tatcatacac aattggccag cagccgggct gttaaggctt gccatgaact
     7921 tttgcctgat tccaagattg ggattgtcct caacttgaca ccggcttatc cacgtagcca
     7981 gcatcctgct gatgtcaagg cagctcgtat tgcggccctt tttcaggccc aatctttctt
     8041 agatccatct gtcttgggga cttatccaca ggagttggta gaaatcttgc atgaacacgg
     8101 tcttttacct gatgctacag aggaagagtt ggaactcatt cgtgataata cggtggactt
     8161 ccttggtgtg aactactatc aacctttgcg tgttatggct cctcgatttg ctaagcatcc
     8221 agagagtcca ctcttaccag aacattttta cgagccttat gtgatgcctg gacgtaaaat
     8281 caattctcac cgtggttggg agatttatga gcaagggatt tatgacatcg cccaaaatat
     8341 caaggaaaat tatggcaata ttgagtggat gttgactgag aatggtatgg gtgttgaagg
     8401 ggaagaaaaa ttccgtcaag atggaatgat tcaagatgat taccgtattg actttgtaaa
     8461 aggtcatctt cgtgaacttc accgtgccat tgaagatggt gccaactgta agggctactt
     8521 gatttggacc tttattgact gctggtcatg gctcaacagc tataaaaatc gctatggttt
     8581 ggtcgaatta gacttggaaa cgcaagaacg tcgtctgaag aaatcaggcc actggttcaa
     8641 agaattaagc gataataatg gattttaaaa aggactctga ctgattatcc caatcggtca
     8701 gagtttttat gcttacagga gcttaatttg aactatacca atttttactc ttgacaagtg
     8761 aaagaaacaa gtatatactg tttttgctga ttctataaaa gatgaattag actataccaa
     8821 ttttaaggag aaagcacagc ttgcctgtgt cgtatatact atgtgtggaa ttgttggtgt
     8881 tgttggaaac acaaatgcaa ctgatatttt gattcaaggg cttgaaaagc ttgaataccg
     8941 tggctatgat tctgcgggaa tttttgtcct agatggtgct gataaccatt tggtgaaggc
     9001 ggttggtcgt attgcagaac tgtctgccaa gacagctggt gttgagggaa caactggtat
     9061 cggacatact cgttgggcta ctcacggaaa accaactgag gacaatgctc acccacaccg
     9121 ctctgagaca gaacgttttg tcttggtgca taatggggtg attgagaact atcttgaaat
     9181 caaggaagaa taccttgcag gtcaccactt caaggggcag acagatactg aaatagccgt
     9241 tcatttgatt ggaaaatttg cggaagaaga agggctctca gttcttgaag ccttcaaaaa
     9301 agcccttcac atcatccgtg gttcttatgc ctttgccttg gttgactcac aagatcctga
     9361 agtcatctac gtagctaaaa ataaatcacc acttttgatt ggtcttggag aaggctataa
     9421 catggtctgc tcagacgcca tggctatgat tcgtgaaact aaccaataca tggaaatcca
     9481 tgaccaagag ttggtaatcg tcaaggctga tagtgtggaa gttcaagact atgatggaaa
     9541 tcgtcgtgag cgtgctagct acactgctga acttgacttg tcagatatcg gtaagggaac
     9601 ttacccttac tacatgctca aggaaattga cgagcaacca actgttatgc ggaaactcat
     9661 ccaagcctac acagatgagg ctggtcaagt tgtcgtagac ccagatatca ttaaggctgt
     9721 tcaagacgca gaccgcatct acatccttgc agctggaaca tcttaccatg caggatttgc
     9781 ttctaagaaa atgttggaag aattgacaga tacaccagtt gaacttggca tctcatctga
     9841 gtggggctac ggtatgccac ttctcagcaa gaaaccactc ttcatcttta tcagccaatc
     9901 tggtgaaaca gcggatagtc gtcaagtttt ggtcaaggct aatgaaatgg gaattccaag
     9961 cttaacagtg acaaatgttc caggctcaac cctctcacgt gaagccaact ataccatgct
    10021 ccttcacgct gggcctgaaa ttgccgtggc atcaactaaa gcctatacag cgcaaatcgc
    10081 agcccttgcc ttccttgcaa aagcagtcgg agaagcaaat ggtaatgcta aagcgcaagc
    10141 ctttgacctg attcatgaat tgtcaatcgt agctcagtct atcgaatcaa ctctttcaga
    10201 gaaagaaacc attgaagcca aggttcgtga acttcttgaa acaactcgta acgcctttta
    10261 catcggacgt ggtcaagatt actacgtagc catggaagca agtctcaaac tcaaagagat
    10321 ttcttatatc cagtgtgaag gctttgctgc aggagaactc aagcacggaa ccattgcctt
    10381 gattgaagaa ggaacgcctg ttttggctct cttgtcagat ccagttcttg ccaatcatac
    10441 tcgtggaaat atccaagagg tcgcagcccg tggtgccaaa gtcctcacta tcgcagaaga
    10501 gaatgtagcc aaagataccg acgatatcgt ccttacgacc gtacatccat acctctcacc
    10561 aatttcaatg gtcgtaccaa cgcaattagt cgcttacttt gcaaccctcc accgtggcct
    10621 cgatgtggac aaaccacgta accttgccaa gtcagtaacg gtagaataag ctaaaaaagt
    10681 ctagttatct aggctttttc ttgtgagcaa attggttgct tgtactcaag attcgtgtta
    10741 gaataatttt tcaaattgaa ggacagagat agacaaggag aatcacaatg gtagaattgg
    10801 gaatttcaac atttggggaa ataacggagc ttgaagggac tggacaaact tacagtcatg
    10861 ctgaacgcat tcgccagttg gtggcagaga ttgagctggc tgacaaggtt ggtttggacg
    10921 tatatgggat tggcgagcac catcgggcgg attttgcagt atcagcccca gagattgtcc
    10981 tggccgctgg ggcagtcaat accaagaaaa tccgtttgac cagtgcagtc agcattctgt
    11041 caagcatgga cccgattcgt ttgttccaac agtatgccac tatcgatgct ttgtcaaatg
    11101 gacgagcgga gattatggct ggaaggggat ctttcacgga atctttccct ctgtttggtt
    11161 atgacttgaa agactacgac tctctttttg atgagaaatt agacttgctt cagttagtca
    11221 atgaaaagac caagttagac tggcaaggtc gattgactca aacgattgct ggtaaagaag
    11281 tttatcctcg tccagttcag gacaaattgc ccttgtggat agctacaggt ggtcatgtcg
    11341 aatcaacagt gaagattgct caggctggtc taccgattgt atatgctatt attggtggta
    11401 atccacgtta ttttaaaaag ttgattcagg cttatcgtga gattggaagc gaagcgggcc
    11461 atgctgacaa agacttgaaa gtgggagccc attcttgggg gtggattgcg gaagatggtg
    11521 agcaggcggt gaaagattat ttccatccga ctaagcaagt ggtggatgct atttccaaag
    11581 accgtccgca ctggcaggaa ttgcgttatg agcaatattt ggagcaggta gggtcaaatg
    11641 gcgccatgtt tgttggcaat ccagatcagg tggccgaaaa attgattcgc atgatagagg
    11701 atttaggatt ggaccgcttc atgcttcatc taccgcttgg ttctatgcct catgaccagg
    11761 ttctgagagc tattgaactc ttcggaacac aagttgcacc caaagtacga gcttattttg
    11821 ctatgaaaga ggcttaataa aaaatcctaa tcaagtttat taggacaaca aatattgtac
    11881 gaaaattaat cccccgagct ataatgcttg ggggattttt ctataggagg gctagcttag
    11941 ttctcttttt tattttttag taagaaaccg agaccaagga gcgcaaggag gctgattcct
    12001 gcaaatagga gtttgttttc gtttttgatt cctgtatttg gaagttcagc ttgtctatct
    12061 ggggttgcag atatattttc cttgctagag ttttctaccg attcttttcg aaccgcttct
    12121 tttacagatg atgcttgtgc ttcttgtgct ggttgttcag cttgtgaatc agctgtagct
    12181 tggctaggtt tattttccgc atcagctact ttggcatctg gtttagtaga atcaggtcta
    12241 gcttctggag ctgggtcttg atgtgcaggg tgagaagctt cattttgatg ttcaggcttg
    12301 gaaggggttg agtctggttt ctcttctgca gttgactcat ggctagttcc attttgagag
    12361 actcgaagaa cagtagctgt aagggcattc aatttcaagc ctttttcagt ccattcaagt
    12421 cctttcgggt tggcaattcc gactgatcct gcttggtttt catctgccaa aacttccgca
    12481 tttcttagat gtgcaaaggc agttcccaaa ttaaattcgc gagctttttc atccgcattg
    12541 acaaagactg cgtagatatc gccgtttgga gcagtgattt gatagccaat cactacatcc
    12601 tctttttcca caccattttg gcctgggaca gtgatgaggt ggacacggtc tttgatatct
    12661 tgaagactct taagtcggaa ggcatctgta gattgacgaa gggcaatcaa acctttcata
    12721 tagtcacggc tcttgacatt ttcaggataa gctttaccat ctgtagcctt agtccagtca
    12781 aacttgttga ctgcatcact agaatcgtaa gagtcatgga tgaagtaagg atagtcaaat
    12841 gggttgccgt ccttatcacg caacaagtga gatttgtttg gaaccttatc ctctgctact
    12901 ggagtcttgt aggctgggtc acggaattgt ttagtacgtc catattcctg accggagtgg
    12961 ataaatggag ttccttgagc tgtcaagacc atgagatttc caagtcgtaa acgacggtgg
    13021 atttcagcat agttctcagc cttgcttggg tcttttttga tagactgggc aatgatgtca
    13081 aagagggtca agttatcatg ggctgcgatg tattggatga catctccagg gctgtcagct
    13141 tcaaagttag ttggttgagc aatgagattt ttaaagatgg tgttgacatc acgcttgcca
    13201 cctgtgataa aggcaggttg accttcgttt ggataaccag atttgaggtt gttacggatg
    13261 tcatctgaaa agacagcgac agtatcggta tgtttcatcc aatcttggtc agcagcttta
    13321 gtaggcatgt tttcatcacc ggcataggtt ctccaacctt cgcctaacat gattagattt
    13381 ggattgaggg cgcgtgcagc cttgtaagct tcttcgatag aagcggcgtc atggtctccc
    13441 atcatatcga agcggaagcc atccactttg taggtatcaa ctaggtattt gatagagtca
    13501 actaggagcc gtttggtcat atggtgggtt gtccccaagc gtccaccacc aaagctagtt
    13561 cgaggtgtgc catcggcatc cataaagtgg tagtagtttg gctctaggtc ttcaaagata
    13621 tcgactttgg ctgtgtggtt ataaacgaca tctaggatag ctcccatacc acgtttgtgg
    13681 atttcgttga tgaggttttt aaattctgcg attcgttttt ctggattctt aggatcgctt
    13741 gagtacatac cagtcaagga gaagtagttt tgagggtcat atccccagtt gtagttgctg
    13801 ttgcttgaag catagtcaga caagcgttca tggtttttca attcattgac aaagtagtaa
    13861 gacaagactg gaaggagctg gatatgggtt acacccaagt ctttgagata gtctagtttt
    13921 tcaatgaagg cttcaaaagt cccaaatggt ttggtcaagt cttttgcaat ggcaggatct
    13981 gaagtgaagt cacgcacatg agcttcgtag ataacggcgt cttcacgagt cttgaaattg
    14041 tgaatcttac cataagtcaa gtcttgaggt ccgagtttag ctggatctac aaaggcggct
    14101 ttagccactt tatgggcatc gtcaatcttg gcatcgtcgc tattccaagc agcaagagat
    14161 ttagcgtaag gatcgagtgc aagaacagtt ttaccttgac gctcgatttg gtattgataa
    14221 tagtagccag tgaaatctgt gattccgagt ttgtttgtgc tgtctagagt ttgtttccaa
    14281 gttcctcttt cccctttttc gagagcgaca gttccaacta ctttgtcagg gtcattcttg
    14341 tcgtagacaa caacagaaac cttatcagca cttggtgacc aaagggtcaa atcaacttgt
    14401 tttccttctt cttttaggtc agctcccagt ttgccatcat agctgtatgt ctcatctttc
    14461 aggcgccagc ttgttttggt agtgaattgg tcggaattgt agctaacagt ataaggatgt
    14521 tttgtgtcag agaaatctcc gctgtaggtc actttcttac cagcttcatc gattgcaaca
    14581 tcggtaatag ttaccttgtt tcctaggtga ttagtgatgt tggagtgttt gaggatatct
    14641 tcttttttag caccgacaag tgttgaaaag ctactttcaa tgctagaagt gcctacgtgt
    14701 tgggctcctg tcatacggat atcatggaca tagtatggat ttgtgtaaat cgattcatca
    14761 tcgtctttta ggaaaatttg gctatgattt ttcaaatctg tgaacttata attttcttta
    14821 cggattttca cgtcgtctcc ttgtttgctc tcatctagta ataaaaatcc aaattctctt
    14881 gcggcttcat taagaggaat gtcgatatag cggccatatt tgcctgtagc cgtaaagtct
    14941 gttccgtcag gccattgagc gctacttgga ttttttacat ctccccagta ccagagagat
    15001 ttcttgtcat agttgccatc tgtgcggtag tagttgacgc gaacagttcc tgcaggctgt
    15061 ggctcgtaag agaaaacctt gtaatcttgg tctaaccaag cttcgttcat ttttggaact
    15121 agtttttcta cagatttatc gccggttaga ttttttccag ctgtattgtt gatgaggaag
    15181 ctaattttct tggcttgttc tccctttaat ttgacatcta ggtaatagcc gtagtcatct
    15241 ttcttggcat ccttgaagga caaagctccg tttggccagt tttcagatgg tttttcaaca
    15301 tcgtcccaag tccatagtcc ttgagcatcc ttgttttctt caggaagttt tttgacatgg
    15361 atacggaagt agttatcttc gatgggctct tctgccttag tttcagttgt tactggacta
    15421 gtagaagtag ttggctcact tgaacgatct tgtccagttt gtggtgctga atcggctggg
    15481 cttgcagcag gtttttcttc tgttttctct agggaagcgt ttgcatttct aggtgaagaa
    15541 atatcacttt cgttcttacc agagccagct gctgtatcag taagaggttg ggcaagggtg
    15601 gttgtatttc tgttgttggg ttcgttagtg gttggtgtac tttcgtcgga tgagatagtt
    15661 ggtgtagcca tggcaagcaa gacaaggctt gcgccgataa ggacagaacc agttccattt
    15721 ttgagggaac ggatgctgta gaccattttt ttctcagtgt gagatggtgt ttttctcata
    15781 atgattctcc aatcaataaa tttctatatc agtatagcat gtagtaaaac aatatgcaag
    15841 cgttttcttt gatttgtgaa aaaaattcct acttttgaga agttttctgt actattttat
    15901 atatcagtat aaatgacgga gataaaaatg tcacataagc caagccgtat tattaggaag
    15961 atgatgtgtt cccagctatt tttattcaga aattgatctc taacattacc aataaaaaag
    16021 aaaaatatct tgacaagcaa gggaaaattt tgttacaata atagacggta ctttttactt
    16081 ttggtctctc aagagtgtac agggacgtgc tgacaaatgt tgcaaaagta cacacagatg
    16141 atatctgtca ccaagtgtat catcaccaaa aataaaaaaa cacaggagaa tgtagatgcc
    16201 tacaattaac caattggttc gcaaaccgcg taaatcaaaa gtagaaaaat ctaaatcacc
    16261 agctttgaac gttggttaca atagtcataa aaaagttcaa acaaacgttt cttcaccaca
    16321 aaaacgtggt gttgcaactc gtgttggaac aatgacacct aaaaaaccta actcagccct
    16381 tcgtaaattc gctcgtgtac gtttgagcaa ccttatcgaa gttactgcct acatcccagg
    16441 tatcggacac aacttgcaag agcacagcgt ggtgcttctt cgcggtggac gtgtaaaaga
    16501 ccttccaggg gtacgttacc atatcgtccg tggtgcactt gatactgcag gtgttaacga
    16561 tcgtaaacaa ggccgttcta aatacggtac taaacgtcca aaagcataag gaaaggggat
    16621 aaagagaaat gagtcgtaaa aatagagctc caaaacgtga cgtattgcca gatccgctat
    16681 acaattcaca actagttact cgtcttatca accgcgttat gcttgatggt aaacgtggta
    16741 ctgctgcttc aatcgtttac ggtgcttttg agcaaatcaa agaagctact ggcaacgatg
    16801 cacttgaagt atttgaaaca gctatggaaa acatcatgcc tgtacttgaa gtacgtgcac
    16861 gtcgtgttgg tggttctaac taccaagtcc cagttgaagt tcgtccagaa cgtcgtacaa
    16921 cacttggact tcgttggttg gtaacaatcg ctcgtcttcg tggtgaacac acaatgcaag
    16981 accgtcttgc aaaagaaatc ttggatgctg ctaacaacac tggtgcagca gttaagaaac
    17041 gtgaagatac tcaccgtatg gctgaagcta accgtgcatt cgcacacttc cgttggtaag
    17101 ataggatgcg aaagcgttaa gaaagtccca gagaaaatag ggaatcgaag caggttgcgg
    17161 ttgcaaccaa tgagattcat ctttttctcc agacttttag cttgagctca actaaatcat
    17221 gatgctaggc acggtaagga tgcaaggtga aaataggaaa ctgacgcagt attcaacgaa
    17281 tacaaggagt tttatctttt tcacgcaaca tcccgttcca gctcacatcg gctaactaac
    17341 tttagcctgg gttcaaatta gctaaatcga ttagtattag ctataactca gcttaccatc
    17401 tcgtaagttg aaaccaacaa tagcatgaaa acattgagaa cgggtaggtc ctgcctatcc
    17461 gtttttatta aaatcgtgtt ataatagaat agaaatcaaa aataaatagg agaaacaaac
    17521 ctcatggcac gcgaattttc acttgaaaaa actcgtaata tcggtatcat ggctcacgtc
    17581 gatgccggta aaacaacaac tactgagcgt attctttact acactggtaa aatccacaaa
    17641 atcggtgaaa ctcacgaagg tgcgtcacaa atggactgga tggagcaaga gcaagaacgt
    17701 ggtatcacga tcacatctgc tgcgacaaca gctcaatgga acaaccaccg cgtaaacatc
    17761 atcgacacac caggacacgt ggacttcaca atcgaagtac aacgttctct tcgtgtattg
    17821 gatggtgcgg ttaccgttct tgactcacaa tcaggtgttg aacctcaaac tgaaacagtt
    17881 tggcgtcaag caactgagta cggagttcca cgtatcgtat ttgccaacaa aatggacaaa
    17941 atcggtgctg acttccttta ctctgtaagc acacttcacg atcgtcttca agcaaatgca
    18001 cacccaatcc aattgccaat cggttctgaa gatgacttcc gtggtatcat tgacttgatc
    18061 aagatgaaag ctgaaatcta tactaacgac cttggtacgg atatccttga agaagacatc
    18121 ccagctgaat accttgacca agctcaagaa taccgtgaaa aattgattga agcagttgct
    18181 gaaactgacg aagaattgat gatgaaatac ctcgaaggtg aagaaatcac taacgaagaa
    18241 ttgaaagctg gtatccgtaa agcgactatc aacgttgaat tcttcccagt attgtgtggt
    18301 tcagccttca aaaacaaagg tgttcaattg atgcttgatg cggttatcga ctaccttcca
    18361 agtccacttg acatcccagc aatcaaaggt attaacccag atacagacgc tgaagaaatt
    18421 cgtccagcat ctgacgaaga gccatttgca gctcttgcct tcaagatcat gactgaccca
    18481 ttcgtaggtc gcttgacatt cttccgtgtt tactcaggtg ttcttcaatc aggttcatac
    18541 gtattgaata cttctaaagg taaacgtgaa cgtatcggac gtatccttca aatgcacgct
    18601 aacagccgtc aagaaatcga cactgtttac tcaggtgata tcgctgctgc cgttggtttg
    18661 aaagatacta caactggtga ctcattgaca gatgaaaaag ctaaaatcat ccttgagtca
    18721 atcaacgttc cagaaccagt tatccaattg atggttgagc caaaatctaa agctgaccaa
    18781 gacaagatgg gtatcgccct tcaaaaattg gctgaagaag atccaacatt ccgcgttgaa
    18841 acaaacgttg aaactggtga aacagttatc tcaggtatgg gtgaacttca ccttgacgtc
    18901 cttgttgatc gtatgcgtcg tgagttcaaa gttgaagcga acgtaggtgc tcctcaagta
    18961 tcttaccgtg aaacattccg cgcttctacc caagcacgtg gattcttcaa acgtcagtct
    19021 ggtggtaaag gtcaattcgg tgatgtatgg attgaattta ctccaaacga agaaggtaaa
    19081 ggattcgaat tcgaaaacgc aatcgtcggt ggtgtggttc ctcgtgaatt tatcccagcg
    19141 gttgaaaaag gtttggtaga atctatggct aacggtgttc ttgcaggtta cccaatggtt
    19201 gacgttaaag ctaagcttta tgatggttca tatcacgatg tcgactcatc tgaaactgcc
    19261 ttcaagattg cggcttcact ttcccttaaa gaagctgcta aatcagcaca accagctatc
    19321 cttgaaccaa tgatgcttgt aacaatcact gttccagaag aaaaccttgg tgatgttatg
    19381 ggtcacgtaa ctgctcgtcg tggacgtgta gatggtatgg aagcacacgg taacagccaa
    19441 atcgttcgtg cttacgttcc acttgctgaa atgttcggtt acgcaacagt tcttcgttct
    19501 gcatctcaag gacgtggtac attcatgatg gtatttgacc actacgaaga tgtacctaag
    19561 tcagtacaag aagaaattat taagaaaaat aaaggtgaag actaatccgt cctcactcta
    19621 gaaggaagtc acttagtggc ttccttttgt ctttagaaaa tacctctaaa tatggtaaaa
    19681 tagtagaaga ataatgtgag gaaaatgaat gtcaaatagt tttgaaattt tgatgaatca
    19741 attggggatg cctgctgaaa tgagacaggc tcctgcttta gcacaggcca atattgagcg
    19801 agttgtggtt cataaaatta gtaaggtatg ggagtttcat ttcgtatttt ctaatatttt
    19861 accgattgaa atctttttag aattaaagaa aggtttgagc gaagaatttt ctaagacagg
    19921 caataaagct gtttttgaaa ttaaggctcg gtctcaagaa ttttcaaatc agctcttgca
    19981 gtcctactat agggaggctt tctctgaagg tccatgtgct agtcaaggtt ttaagtccct
    20041 ttatcaaaat ttgcaagttc gtgctgaggg taatcagcta tttattgaag gatctgaagc
    20101 gattgataag gaacatttta agaagaatca tcttcctaat ttagccaaac aacttgaaaa
    20161 gtttggtttt ccaactttta actgtcaagt cgagaagaat gatgtcctga cccaagagca
    20221 ggaagaggcc tttcatgctg aaaatgagca gattgttcaa gctgccaatg aggaagcgct
    20281 ccgtgctatg gaacaactgg agcagatggc acctcctcca gcggaagaga aaccagtctt
    20341 tgattttcaa gcgaaaaaag ctgcagctaa acccaagctg gataaggcgg agattactcc
    20401 tatgatcgaa gtgacgacag aggaaaatcg tctggtattt gaaggggttg tttttgatgt
    20461 ggagcaaaaa gtgactagaa caggtcgtgt tttaatcaac tttaaaatga cggactatac
    20521 ttcaagtttt tctatgcaaa agtgggttaa aaacgaggaa gaggcccaga agtttgacct
    20581 catcaagaag aattcttggc tccgagttcg agggaatgtg gagatgaata acttcacacg
    20641 cgatttgact atgaacgtac aggatctgca ggaagttgtt cactatgagc ggaaggattt
    20701 gatgccagaa ggtgagcgtc gggttgagtt tcatgctcat actaacatgt cgactatgga
    20761 tgctttgcca gaggtcgaag agattgttgc aacagctgct aagtggggac acaaggcggt
    20821 tgctatcaca gaccatggga atgtccagtc ctttccacat ggctataagg cggctaagaa
    20881 agcgggaatc cagctgatct atgggatgga agccaatatc gtggaggacc gtgtccctat
    20941 cgtctataac gaagtggaga tggacttatc agaagcaatc tacgtggtct ttgacgtgga
    21001 aacgacggga ctttcagcta tctataatga cttgattcag gttgcggcct ctaagatgta
    21061 caaggggaat gttattgctg aatttgatga atttatcaat cctgggcatc ccttgtcagc
    21121 ttttactaca gagttaactg gaattacaga tgatcatgtc aaaaatgcca aaccactaga
    21181 acaagttttg caagaattcc aagaattttg caaggatacg gtcctagttg cccacaatgc
    21241 tacctttgac gttggcttta tgaatgctaa ttatgagcgg catgatcttc caaagattag
    21301 tcagccagtt attgatacgc tggagtttgc tagaaacctc tatcctgagt ataaacgcca
    21361 tggtttgggg cctttgacca agcgttttgg tgtggccttg gaacatcacc acatggccaa
    21421 ctacgatgcg gaagcgactg gtcgtctgct tttcatcttt atcaaagagg tagcagaaaa
    21481 acatggtgtg accgatttag ctagactcaa cattgatcta atcagtccag attcttacaa
    21541 aaaagctcgg atcaagcatg cgaccatcta tgtcaagaat caggtaggtc taaaaaatat
    21601 ctttaagctg gtttccttgt ctaataccaa gtattttgaa ggagtgccac ggattccgag
    21661 aacggttcta gatgcccatc gagagggctt gattttaggt tcagcctgtt cagagggtga
    21721 agtttttgac gtggtcgttt ctcaaggtgt ggatgcggcg gttgaggtgg ccaagtatta
    21781 tgactttatc gaggtcatgc caccggctat ctatgcgccc ttgattgcca aagagcaggt
    21841 caaggatatg gaggaactcc agaccattat caagagtttg atagaggttg gagaccgcct
    21901 tggcaagcct gttttggcta cgggaaatgt tcactatatc gaaccggaag aagagattta
    21961 tcgtgaaatt atcgtccgta gtttgggaca gggtgcgatg attaaccgaa ctatcggtca
    22021 tggtgaacat gcccaaccag caccacttcc aaaggctcat tttcgaacga ctaatgagat
    22081 gttggatgaa tttgcctttt tgggagagga actggctcgt aaactggtta ttgaaaacac
    22141 caatgccttg gcagaaatat ttgaacccgt tgaagtcgtt aagggtgact tgtatacgcc
    22201 tttcatcgac aaggctgaag aaacagttgc tgagttgacc tataagaaag cttttgagat
    22261 ttatggaaat ccgctgccag atattgttga tttgcggatt gaaaaagaat taacatccat
    22321 actggggaat ggatttgctg tgatttatct ggcatcgcag atgctggtgc aacgttctaa
    22381 tgaacggggt tatttggttg gttctcgtgg gtctgtcgga tctagtttcg ttgcgaccat
    22441 gattgggatt acggaggtca atcctctctc tcctcactat gtctgtggtc agtgtcagta
    22501 cagtgagttt atcacagatg gttcgtacgg ttcaggattt gatatgcccc ataaggactg
    22561 tccaaactgt ggtcacaaac tcagtaaaaa cggacaggat attccgtttg agaccttcct
    22621 tggttttgat ggggataagg ttcctgatat tgacttgaac ttctcgggag aagatcagcc
    22681 tagcgcccac ttggatgtgc gtgatatctt tggtgaagaa tatgccttcc gtgcgggaac
    22741 agttggtacg gtagctgcca agactgccta tggatttgtc aaaggttacg agcgagatta
    22801 tggcaagttt tatcgtgatg cagaagtaga acgcctcgct caaggagcgg cgggtgtcaa
    22861 gcggacaaca ggccaacacc cggggggaat cgttgttatt ccgaactaca tggatgtcta
    22921 cgattttacg cctgtccagt atccagcaga tgatgtcacg gctgaatggc agaccactca
    22981 ctttaacttc cacgatatcg atgagaacgt cctcaaactc gatgtactgg gacatgatga
    23041 tccgactatg attcgaaaac ttcaggattt gtctggtatt gaccctaata aaattcctat
    23101 ggatgacgaa ggcgtgatgg cactcttttc tgggactgat gtgctagggg taacacctga
    23161 acaaattgga acgcctacgg gtatgttggg gattccagag tttggaacaa atttcgtacg
    23221 tggaatggta gacgaaaccc atccgacaac ctttgcggaa ttgcttcagc tgtctggtct
    23281 gtcccacggt actgatgttt ggttggggaa tgctcaggat ctgattaagc aaggaatagt
    23341 ggacctatcg actgttatcg gttgtcggga cgacatcatg gtttacctca tgcatgcggg
    23401 tctggaacct aagatggcct ttaccattat ggaacgggta cgtaagggtt tgtggctaaa
    23461 gatttcagaa gaggagagaa atggctatat cgaagcaatg aaggctaata aggtgccaga
    23521 gtggtatatc gaatcctgtg ggaaaattaa gtacatgttc cctaaggccc atgcggcagc
    23581 ctacgttatg atggccttgc gtgtagctta cttcaaggtt caccatccta tttattacta
    23641 ctgtgcttac ttctccattc gtgctaaggc ttttgatatc aagaccatgg gtgcgggctt
    23701 ggaggtcatc aagcgcagaa tggaagaaat ctctgaaaaa cggaagaaca atgaagcctc
    23761 taatgtggaa atcgatctct atacaactct tgagattgtc aatgagatgt gggaacgagg
    23821 tttcaagttt ggtaaattag atctctactg tagtcaggcg acagagttcc tcatcgacgg
    23881 ggataccctt atcccaccat ttgtagcaat ggatggtctg ggagagaacg ttgccaagca
    23941 actggtgcgg gcgcgtgaag agggagaatt cctctctaaa acagaactac gcaagcgtgg
    24001 tggactctca tcaaccttgg ttgaaaagat ggatgagatg ggtattcttg gaaatatgcc
    24061 agaggataac cagttgagtt tgtttgatga gttgttttaa aaaattgctt aataatctat
    24121 taaaagaggc taacgtatat ccaatagatt tacattagct ttcttttttg ttaaaatagt
    24181 ctatggaaag agggtgagag tatgtcaaag atgagtataa gcatccgtct ggatagtgag
    24241 gttaaggagc aggcccaaca ggtgtttagt aatctgggaa tggatatgac aacagctatt
    24301 aatattttcc ttcgtcaggc aattcaatat cagggattac cttttgatgt tagactagac
    24361 gaaaatcgga agttgctcca agcgttaacg gatttagacc aaaatcgtaa tatgagccag
    24421 tcttttgaat cagtctcaga tttgatggag gacttacgtg cttaagattc gttatcataa
    24481 acagttttaa aaagatttta agttggctat gaagcgtggt ttgaaggcag aattattaga
    24541 agaagttttg aattttctgg ttcaagaaaa agaacatcct gccagatatc gtgatcattc
    24601 attgacggca tccaagcatt ttcaaggagt tcgtgaatgc tatacccagc cagattggct
    24661 tttggtttat aaagtagaca agtcggaatt gattttaaat ttgctgagga caggcagtca
    24721 cagtgattta ttttaatcta ttttaagggg gttctcatga aactaagaat atttgcggaa
    24781 gataagccgg ctaagaaggt atttgaatat caattagaac ttgctgatcg tacaattctt
    24841 ctatcgacag cactcttgtc aggtgctatt gctttagcag gaatcttttc tgctttgaaa
    24901 gaaaaataaa aatagaaaag agaaaacagg atggttttac caaattttaa agaaaatcta
    24961 gaaaaatatg cgaaattgtt ggttgcgaac ggaattaacg tgcaacctgg tcacactttg
    25021 gctctctcta ttgatgtgga gcaacgtgaa ttggcacatc taatcgtgaa agaagcttat
    25081 gccttgggtg cgcatgaggt catcgttcag tggacagatg atgtgattaa ccgtgagaaa
    25141 ttcctccatg ccccgatgga gcgtttggac aatgtgccag aatacaagat tgctgagatg
    25201 aactatctct tggagaacaa ggctagccgt cttggagttc gttcatctga tccaggtgcc
    25261 ttgaacggag tggacgctga caagctttca gcttctgcta aagctatggg acttgccatg
    25321 aagccaatgc gaatcgcaac tcaatctaac aaggttagct ggactgtagc agccgctgct
    25381 ggacttgagt gggctaagaa agtcttccca aatgctgcga gcgacgaaga agcagtcgat
    25441 ctcctttggg accaaatctt caaaacttgc cgtgtctacg aagcagatcc tgttaaggcc
    25501 tgggaagagc atgcagccat tctcaagagc aaggccgata tgcttaataa ggagcaattt
    25561 tcagcccttc actacacagc gccaggaaca gatttaacac ttggtttgcc aaagaaccac
    25621 gtttgggaat cagctggtgc tgtcaatgca cagggcgaag gattcttgcc aaatatgccg
    25681 acagaagagg tcttcacagc gcctgacttc cgtcgtgcag atggttatgt cacttctaca
    25741 aaaccgctta gctacaacgg aaatatcatt gaaggcatta aggtgacctt taaggatgga
    25801 caaatcgtag atatcactgc tgagaagggt gatcaggtta tgaaagacct tgtctttgaa
    25861 aatgcgtcaa accacttggc tatcggtgca gcctatgcga ctagcgttgt tgatggagcg
    25921 gagatgagcg aagaggagct tgaagctgca gggcttaacc gttcagatgt tcacgtagac
    25981 tttatgattg gttctaacca aatggatatc gatggtattc gtgaggatgg aacgcgggta
    26041 cctcttttcc gtaatgggaa ttgggcaaat taaggagata atatgttagg aagtatgttc
    26101 gttggtctcc tagtgggatt tttagcaggt gctatgacca atcgtggaga gcgaatggga
    26161 tgttttggaa aaatgtttct cggttggatc ggagcctttc taggtcactt gctctttgga
    26221 acttgggggc cagttttatc aggaacagct attatcccag cgattttagg agccatgatt
    26281 gttttagcta ttttttggag acgaggaagt taatttccta aatctgatac tcaatgaaaa
    26341 tcaaagagca aactaggaaa ctagccgcag gttgctcaaa gcactgcttt gaggttggag
    26401 atagaactga cgaagtcagc tcaaaacact gttttgaggt tgcagataga actgacgaag
    26461 tcagtaacat atatacggca aggcgacgtt gacgcggttt gaagagattt ttgaagagta
    26521 tgaaacgaaa aggaggttgg tcattgtact agcctccttt tgatatgata taatagttct
    26581 atgagattag ataaattttt agttgcctgt gcggtgggaa gtcggactga ggtcaaaaac
    26641 ttgctcaagg ctgggcgcgt gactgtaaat ggtaaaaaag aaaaatcagc taaattgcag
    26701 attgatgaaa aaatagatga gattcgcttt gatgggcaag tgttggagta tgaagagttt
    26761 gtctactaca tgatgaacaa gcccaaagga gttatctcag cgactgagga tcccaagcac
    26821 agaaccgttc tggacttgtt ggatgacttg gcgcggagta aggaagtttt cccagtagga
    26881 cgcttggata ttgacacgca tggtcttttg ctcttgacca atgatggtca gctggctcat
    26941 gttcttcttt cgcccaagcg tcatgtggac aagacttatc tggcacaagt caagggaatc
    27001 atgacccaag aagatgtgga gacatttgct gagggtattc ctctcaaaga ctttacctgt
    27061 caacccgcta tactggagct tgtatccata gatacagaaa agaatcaaag ccaaatccgt
    27121 gtgaccattg cagaagggaa gtttcatcag atcaagcgta tggtgggcta ctgtggcaag
    27181 gaagtggtgg acttgcaacg attgactatg ggaactttag tattagatga gaacctagaa
    27241 cgaggggaat ggcgtcgctt gaccaaggaa gaattagaaa ttctccgcgc taatattatt
    27301 taatttagtt taatactcaa tgaaaatcaa agagcaaact aggaaactag ccgcaggctg
    27361 tacttgagta cggcaaggcg acgttgacgt ggtttgaaga gattttcgaa gagtataaat
    27421 tcgaaaaagg tgagggacaa tgtcctcgcc ttttatgttt tttagttgct tcctttgtga
    27481 aaagagttat aatagactgt agaataaaag gaggaatcta tgaacgcgat tcaagaatca
    27541 tttactgata aactatttgc caactatgaa gcaaatgtaa aataccaagc gattgaaaat
    27601 gctgccagcc acaacggaat ttttgcagct ctggaacgtc gccaaagcca tgtagacaac
    27661 acacctgttt tctcattgga tttaaccaag gacaaggtca ctaaccagaa agcgtctggt
    27721 cgttgctgga tgtttgcggc tctcaacacc ttccgccaca aactcatctc gcaatacaaa
    27781 ttggagaact ttgaattgtc acaagcccac actttcttct gggataagta tgagaaatca
    27841 aactggttct tggagcaagt cattgcgact tcagaccaag aattgactag ccgcaaggtt
    27901 agcttcttac tccaaacacc tcaacaagat ggtggtcaat gggatatggt cgtttccctc
    27961 tttgaaaaat acggtgtcgt gcctaagtca gtttatcctg agtctgtttc atctagcagc
    28021 agtcgtgagc taaatgcgat ccttaataaa ttgcttcgtc aagatgctca aatcttgcgt
    28081 gacttgcttg tttctggtgc agatcaagcg actgttcaag ctaagaaaga agacctcttg
    28141 caagaaatct ttaactttct tgctatgtca ttaggacttc caccacgcaa gtttgacttt
    28201 gcttatcgcg ataaagataa caactacaaa agtgaaaaag gaatcacacc acaagagttt
    28261 tacaagaaat atgtcaatct tcctttagaa gactacgttt ctgttatcaa tgctccaact
    28321 gctgataaac cttacggaaa atcttacaca gttgagatgt tggggaatgt ggttggtagc
    28381 cgtgcagttc gctacatcaa cgttccaatg gagcgcttga aagaattggc gattgcccaa
    28441 atgcaagcag gtgagactgt ttggtttggt tctgatgtcg gccagctcag caaccgtaag
    28501 gctggcatcc ttgcgacaga tgtttatgac tttgaatcaa gcatggacat taaacttact
    28561 caagacaagg ctggacgttt ggactatagt gaaagcttga tgacccacgc catggtcttg
    28621 acaggtgttg acttggacga aaatggtaaa tcaaccaagt ggaaggttga aaactcatgg
    28681 ggagacaagg tcggtacaga tggttacttt gttgcctcag acgcttggat ggacgaatac
    28741 acataccaaa tcgttgttcg taaggaattg ctgacagcag aagaacaagc tgcctatgga
    28801 gcagaaccaa tcgtacttgc accatgggat ccaatgggag ccttggctga ataaaagcat
    28861 agaaaaaagg aatcagattt tagaacctgg ttccttttta gttgcttgat tacatgatgt
    28921 gaagaacatg tgccacaata cccactgcga agagggcaag gataatagtg attggagata
    28981 cttttttctt aagtaagtac atgcaaagta aagtaaggag tagtcctgat aatccaggaa
    29041 tcaacatatc caagttttgt tggaaagtag taactttttc aggagtttga gacaatcctt
    29101 gtcctacttg tgcgaatgct tcttggatac ctttagaccc ttctggcaat ttatcccaat
    29161 ggatataagc cttttcatct agttgaactt tagaaacatc gaaagcaaat ttaatattta
    29221 cccagcgttg aacaaggaca gcaagaatga acatcccaag gatagaagct cctttagtga
    29281 tatcttgaag gataccacca gacatatctt tagtgatttc tgatccagcc ttgtatccaa
    29341 tctcttgaac ataccacaag aatgacatac gaatcaagtt ccatgcaaca aagaagagga
    29401 gtggccccaa gatattgcca gtaagggcaa gtgaagcacc gagagatcca aggattgggc
    29461 gtactgtaaa ccagaatact gggtcaccga taccagcaag aggtcccatc ataccgattt
    29521 taaccccttg gatagcagcg tcatcgattt ccacaccgtt agcacgttct tcttcaagcg
    29581 caagagtaac ccccatgact ggagcagcta cgtatggatg agtgttgaag aactcaaggt
    29641 gacgttcaag agcagcgatt tgatcttctt ttttagtata gagttttttg atagctggaa
    29701 tgagtgtata agcccagccc aagttttgca tccgttcaaa gttccaagac ccttgtaaga
    29761 aggttgaacg ccaccaaact tttttacgat ctgatttagt taattgaagt ttttcagtca
    29821 tgatgttttc agtcctttct tatcttagta gtcttctagg atatcgccga ttgggtcgtt
    29881 agaagttgcg gctcctccgc caccatttcc accagtttta gaaaggtgaa ggtagataag
    29941 agcgatagca acaccgatag caccgaatcc gattagagta atatctgaca cagcagcgag
    30001 aacgaaacca agagcgaaga atggccatac ttcacgagtt gccatcatgt tgataaccat
    30061 ggcgtaacca acggcaacga ccataccacc accgatagcc ataccatctt tgagccagtc
    30121 tggcatggca ctaaggatac tttgtacagt ttcagttggt accataagga gaagagctgc
    30181 aggaagcgcg atacgaagtc cttggaagag tagcgcaatg aaatgcgcac gctccacagc
    30241 gccgaagtca ccttttttag cggcagcatc tgcagtatga accaaaccaa ctgaaattgt
    30301 acgaacaatc attgtcaaga aaagtccagc tacggcaaga gggatagcaa ccgcttgggc
    30361 aacaccgata ccagtcttgg taaagtcacc accaagaacc atgataatgg cagcagcgac
    30421 agaagcaagt gcagcatcag gagcgatagc agcaccgata tttgaccaac caagggcaat
    30481 catttgaagc gatccaccga ggataatccc tgcttccaag tgacctgtta caagcccaat
    30541 aagggtacag gctacaagtg gttggtgaaa ttggaactgg tcgaggatgc cttcaagacc
    30601 tgcaaagaag gctacaacga ctactaaaac catagaaata atagacatgt ttaaaatcct
    30661 ttcataaata atggcttatt tgacattggc tttgttaatc aagtcaaaca aatctttttt
    30721 agaatcattt ggtactttac ggacatcaaa ttcaacaccc aagtcacgca ttttttcaaa
    30781 tgtagcaaca tcttctttgt ccatagacaa aacggtattg accaatgttt tacctgttga
    30841 gtgagccata gaaccaacgt taagagtctt gattggcacg ccgccttcga tggcacgaag
    30901 ggcatcttga ggtgtttcaa acaagataag ggcatgtgtt tctccaaaac gtgggtcttt
    30961 tgaaatctca atcagttttt gaattggaac cacgttagcc ttgacattac ctggagctgc
    31021 ttgtttaatc aattctttac gaaggtcgtc tttagccacg ttatctgaag caacgatgat
    31081 acgatttgct tttgaatctg gagtccaagc agttgcaacc tgaccgtgaa gtagacgtgt
    31141 gtcaagacgg gcaagattga ttttcaattt accgtctccg ataacagttc cttctgggat
    31201 agcagtttgg gcaactggag cagctgcagc gcttgcaact tcttcaactg gatttagctc
    31261 ttctggaaga gctttgatgc catctttggc ttctttaatg atattagcag cgactttttc
    31321 tacacctgca gcagcgtcca tgaggcgctc tgtgtaggct tgaatcaaca tcggtaagtt
    31381 aagtcctgtg atgatggcaa acttacgctc aggattttct cccatcacgc gactagcttg
    31441 gttaaatgga gaaccactcc aaaggtcagc caaaactaga acctcatctt ctgcgtcaaa
    31501 tgcagcaaca gcgttattaa acttagcgta tagatcatca ggaccttcat ttggcataaa
    31561 ggtcacaact tgaacctttt cttgttcacc aaagatcata gatcctgact gatgaatacc
    31621 cgcagcaaat tcgccgtggc tcgcaataat gattccgata ctcattattg tcattcctcc
    31681 ttttttgttt tagttttcat ttaagaaaac tttaagactg tttaagtata aaccgttttc
    31741 ataaaaaaag caactattta tcataaaaaa ttaaaaaaat ttttattttt gtatgttgat
    31801 atgttgagtt tttgaggagt aatcttgaat tcttatttaa aaatttaata taaaaaagtt
    31861 ggaagaagtt tccaactttt aaaataggtt tctattagat tagtgggtga agtcgagtac
    31921 catacgtcct tggatttggc ctttttccat ttcgtcgaaa atggcaacag catcttctac
    31981 tggacgtttt tgaacaactg ggactaccag accttctgca ccaaattgga aggcttcttc
    32041 taagtcttta cgagttccga caagagaacc gatgacttgg attccatcga ggactgtttt
    32101 aacgatgctg agttccatca tttcagaagg aagaccaaca gcgacgacgc gaccaccagc
    32161 acgaacggag tcaacagcct ggttgaaggc aactttagac acagcagtta cgacagctga
    32221 atgagctcct ccatcagttt tttctttgat gagtccagct acatcttcaa cttcgaggcc
    32281 gttaatcaca atgtcagcgc ctacttcttt tgcaagggca agtttgtcat tgttgatatc
    32341 gactgcgata acatgagcat tgaatacttt tttagcgtat tgaacagcga ggttaccaag
    32401 tccaccagca ccgtaaagaa caacccattg gcctggttca acttttgctt ctttgatagc
    32461 tttataggtt gttactccag cacatgtgat agaagaagct tgggctggat caagtccgtc
    32521 aggaactttg acagcatagt cagcagttac gatacattgt tcagccatac caccgtctac
    32581 tgagtagcca gcatttttca ctgtacggca aagggtttcg cgaccagttg tacagtattc
    32641 gcaagtgcca catccttcaa agaaccaagc aacgctgacg cggtcaccga ctttaaggct
    32701 tttcacatct ggagcaatct ctttaacgat accgatacct tcgtgcccaa gaacacgtcc
    32761 tgggacttga ccaaagtcac catgagcaac gtggaggtcg gtgtggcaaa caccacagta
    32821 ttcaacttct acaagtgctt ccccagtttc aagtggacgg agtacttttt cttcaatagc
    32881 aacaccagtg ctttctggat ttacaacaac agctttcata gctatcctcc ttgatattga
    32941 ccgagaacag ggacaacggg actggattga ttttttgtca acagagtcga gtgtgacgag
    33001 ctctcttgta tttatatgtg aagtatatca caaaagaaag ccttttccaa ggttttggag
    33061 acaaaaagta gaacaatcga ttaactggtt gatgagactg tgaaaagagc acaaagacca
    33121 gcttgcaagc tggtctttgt gctcttcgaa aatctcttca aaccacgtca gcttcatcta
    33181 caacctcaaa gcagtgcttt gagcaaccta cggctagctt cctagtttgc tctttgattc
    33241 tcattgagta tcagtatagg ttataagaat aagtcttgta gggttttggc aaccccatct
    33301 tggtcgttgg taagggaaat ttgctcatct gcataaggga gtagctctgg attggcattt
    33361 ttcatggcat aacccttccc agcaaaagcg agcatttcgg tatcattgtg ttcatctcca
    33421 aaggcaatca aatctttttt gtcacgattc attatcttga gcaagtagtc caaagcaaag
    33481 gccttgttga caccttttgg ggtacattca aggatattga gcggacctcc ccaggtattg
    33541 atagaaagtt gatgctggta gaaggcgttc atttcttttg ccaaggcata tttgtcactg
    33601 gctctggtct gcaagaggat acagttaggg tccttggtca ccaattcagg ctggaattga
    33661 tcttcaggct ggaaagcttc tacaccaaat agtttgggat tggcaatttc ttcattggga
    33721 tttgtaatgt agaatttttt acgatattct ccagcgataa aatcggcttg aatgtcctct
    33781 gaacgttgaa ccatatctag cagatatttt ttgtctacag tcaaacactt ttcaaaatcc
    33841 caaacttggt ctggtaaatg agtaagggat ccgttgaagt taatcatagg agtgtctaag
    33901 cccagttcac ggtaaaaatc ttttgacata cggtaagggc gacctgtcgt aataataacc
    33961 tgatggcctt tttcagcaac ttttttgatg gttcttttgg taaagtcaga aatttgactg
    34021 tctgagttga gcagggttcc atccaggtca actgcaataa tttttttcgt catatggacc
    34081 tttctagtgt gttttcagat aagatgtctt ctattataac agaaagcagg cagaaaagca
    34141 gattccaaac aaaaaatgaa attggattaa tttcttaaac aaatcaaaca aagacattga
    34201 aaaagtgaat gataaatgat ataattctat tattgttcgt aaaaattaaa aggagattga
    34261 tgatggacaa attatttaaa ctaaaagaga acggtacaga cgttcgtaca gaggttctcg
    34321 ctggtttaac aactttcttt gcaatgagct atattctctt tgtaaaccca caaatacttt
    34381 cacaaacagg aatgcctgct cagggcgtct tcctagcgac gattattggt gcagtagcgg
    34441 gtaccttgat gatggctttt tatgctaact taccttatgc ccaagcgcca ggtatgggac
    34501 tcaatgcctt ctttaccttt acagttgtat tcgggcttgg ttattcttgg caagaagccc
    34561 tagctatggt cttcatctgt gggattattt cattgattat taccttgaca aatgttcgta
    34621 aaatgatcat tgaatcgatt cccaatgctc ttcgctcagc tatttcagct ggtatcggtg
    34681 tcttccttgc ctatgtaggg attaagaatg ctggactttt gaaattcacg attgatccag
    34741 gcaactatac tgttgtagga gaaggggctg acaaagctca agcaacgatt gcagcaaact
    34801 cttcagcagt tccaggattg gtcagcttta ataatccagc tgttttagtg gctcttgcag
    34861 gacttgccat tactatcttc tttgtcatca aagggattaa agggggaatt attctctcta
    34921 tcttgacaac aactgttctt gctattgcag ttggtttggt tgatttgtct agtatcgatt
    34981 ttgctaataa ccatgttggt gcagcttttg aagatttgaa gacaatcttt ggtgcagctc
    35041 ttggttcaga aggtttggga gctttggttt cagatacagc tcgcttgcct gaaactctga
    35101 tggccattct tgccttctca ttgacagata tttttgacac aattggtacc ttgatcggta
    35161 caggtgaaaa agttggtatt gtagcgacaa atggtgaaaa tcaccaatca gccaaattgg
    35221 ataaggctct ttactctgat ttgattggaa cgacagtcgg tgccattgca ggtacttcaa
    35281 acgtaacgac ttatgttgag tctgctgctg gtatcggtgc aggtggacgt actggtttga
    35341 cagccttggt tgtagctatc tgttttgcga tttcaagctt ctttagccca cttctagcga
    35401 tcgtaccaac agcggctaca gctccaatct tgattatcgt tgggattatg atgcttggta
    35461 gcttgaaaaa tatccattgg gatgatatgt ctgaagcagt tcctgccttc ttcacatcta
    35521 tctttatggg attcagctac tctatcactc aagggattgc agttggtttc ttgacttaca
    35581 ctttgactaa gcttgtcaaa ggtcaagtta aagatgttca tgccatgatt tggattttgg
    35641 atgccttgtt tatccttaac tacatcagca tggccttata atagaatgac ccagggggat
    35701 ttcccccctt ttttaataca aaaggagata ggtgatgaaa gagaaaaata tgtggaaaga
    35761 attgttgaat cgtgcaggct ggattttggt ctttttactt gccgtccttt tatatcaggt
    35821 tcccctagtg gttacctcta ttttgacttt aaaagaagta gccctgctac agtcagggct
    35881 gatagttgct ggcctttcaa ttgtggttct ggctctattt attatgggag ctcgtaaaac
    35941 caagttagct agttttaatt tttctttttt tagagctaaa gatttggcac gtttgggctt
    36001 gagttatcta gttattgtcg ggtcaaatat acttggttct atcttgttgc aactgtcaaa
    36061 tgagacgaca actgctaacc agtctcagat taatgatatg gttcaaaata gttcgttgat
    36121 ttccagtttc ttcttgctag ccttgcttgc tccgatttgt gaggaaatct tgtgtcgtgg
    36181 gattattcct aaaaagattt tccgaggcaa ggagaacttg ggatttgtag tcggtacgat
    36241 tgtgtttgct ttattgcatc aaccaagtaa tttaccttct ttattgattt atggaggtat
    36301 gtcgacagtt ctatcttgga cagcctacaa gacccaacgt ttggaaatgt cgatcttgct
    36361 tcacatgatt gttaatggga ttgctttctg tttgttggct cttgtggtga ttatgagtcg
    36421 gacattagga atttctgtgt aaaagttttt atgtaggaac cgacctcttt ctactaggga
    36481 aagatgaatg caatcgtgtc catctttttc tttttatggt aaaatagaaa aataatatga
    36541 tgaaaatcct tgagggagtg accgatatgt caagtaaagc caatcatgca aagacagtta
    36601 tttgcggaat tatcaatgta accccagact ccttttcgga cggtggtcaa ttttttgctc
    36661 ttgagcaggc actccagcag gctcgtaaat tgatagcaga aggagccagt atgctcgata
    36721 tcggcggaga atcgactcgg ccgggcagta gctatgttga gatagaagag gaaatccagc
    36781 gtgttgttcc agtgatcaaa gcgattcgca aggaaagtga tgtcctcatc tctattgata
    36841 cttggaagag tcaagtagca gaggctgctt tggctgctgg tgccgatcta gtcaatgata
    36901 tcactggtct tatgggtgat gagaaaatgc ctcatgtggt agctgaagcg agagcgcaag
    36961 tggtcatcat gtttaatcca gttatggcgc gacctcagca ccctagctcg ctcatcttcc
    37021 ctcattttgg ttttggtcaa gcttttacag aggaagagtt agctgacttt gaaacattgc
    37081 caatcgaaga attgatggag gctttctttg aacgagcact agcgagagcg gcagaagctg
    37141 gtattgcacc agaaaatatc ctgttggatc caggaattgg ctttggtctg accaagaaag
    37201 aaaatctgct tcttttacgg gacctggata aactacatca gaagggctat ccaatctttc
    37261 tcggagtgtc gcgcaagcga tttgtcatca atatcctaga ggagaatggt tttgaagtca
    37321 atcctgagac agagcttggt ttccgcaatc gggacacggc ttcggctcat gtaactagta
    37381 tcgctgcgag acagtgtgta gaagtggtgc gcgtgcatga cgtagctagt cacaggatgg
    37441 cagttgaaat tgcctctgcc attcgtctgg ctgatgaagc ggaaaattta gatttaaaac
    37501 aatataaata agatgaaaga aattgaaaac aatcagtgga ttgctaacta ccggacggat
    37561 caaccgcatt ttggcttgga acgaatggtg gaactgttag ctttgcgtgg caatccccat
    37621 ctcaaactca aggtcctcca tatcggaggg actaacggca agggctcgac tattgctttt
    37681 ttgaaaaaga tgctagaaaa gctagggctg agagttggcg tgtttagctc gccctatctc
    37741 attcattaca cagaccagat tagcatcaat ggggaatcga tctcagaagc gaggctagaa
    37801 gctctcatgg cagactatca gtctttgctg gagggagaag cggtcgccaa tttacagggc
    37861 acaaccgagt ttgagattat cacagccctg gcctatgact actttgcctc agagcaagta
    37921 gatgtggcca tcatggaagt tggcatgggt ggacttttgg atagtaccaa tgtctgtcag
    37981 cccattttga caggaattac aactattggc ttggatcatg tggccctact tggtgacacc
    38041 ttggaggcca tagcagagca gaaggcaggt attatcaaac aagggatgcc cttggtaaca
    38101 gggcgtattg ctccagaagc cttggctgtg attgaccgca ttgcggaagg gaaagatgcg
    38161 ccgagacttg cctacgggac agattatcag gttcgtcatc aagaaagtgt ggtgacaggg
    38221 gaagtctttg actatacaag tgctgtcaga caaggtcgct tccagactag cctgcttggt
    38281 ttgtaccaaa tagagaatgc tgggatggcc atagctttac ttgatacttt ttgtcaagaa
    38341 gatggtcgag agctagcaag caatgacttt cttggtcaag ccttggaaga aacaagttgg
    38401 ccagggcgtt tggaaatcgt gtcaagagat cccttgatga ttttggatgg agcccacaat
    38461 ccccatgcta tcaaggcctt gttggtaacc ttgcaagaac gttttgcgga ttatcataag
    38521 gaaatcctct tcacttgtat caaaaccaag gccttggagg atatgttgga cttgctggga
    38581 gccatgccag ataccgagct tactctaaca cattttgcgg atagtcgggc gacggatgaa
    38641 agcgtgctga aagaggcagc taagtctaga aatctcagct accaagattg gcatgatttt
    38701 ctagagcaga atgtgacaga taaaaaagaa gagaaacaaa cagttaggat tgtcacaggt
    38761 tccttgtatt tcttgagcca agtgagggcc tatctgatgg agaggaagaa cgagaatgga
    38821 tacacaaaag attgaagcag ctgtgaaaat gattatcgag gctgtaggag aggacgctaa
    38881 tcgcgagggc ttgcaggaaa cacctgctcg tgtggcccgt atgtatcaag agattttttc
    38941 aggtcttggt caaacagcag aggaacattt gtcaaaatcc tttgaaatta ttgacgataa
    39001 tatggtggta gaaaaggata tctttttcca taccatgtgt gaacaccact tcttgccatt
    39061 ttatggtaga gcgcacattg cctacattcc agatggtcgt gtggcaggct tgtctaagct
    39121 agcccgtacg gttgaagttt attcgaaaaa accacaaatt caagaacgtt tgaatattga
    39181 agtggccgat gccttgatgg actatctagg tgctaaagga gcctttgttg tcattgaggc
    39241 ggaacatatg tgtatgagta tgcgtggtgt tagaaaacca ggcactgcaa ccttgacgac
    39301 agtagctcgt ggtctatttg aaacagataa ggacctccgc gaccaagctt atcgtttaat
    39361 ggggctataa aaagaatccg cttcaagcgg atttttctag aaaggaatca ttatggatca
    39421 actgcagatt aaggatttgg aaatgtttgc ctatcatggt ctttttccta gtgagaaaga
    39481 attggggcag aaatttgtcg tttcagccat cctatcctat gatatgacca aggcagctac
    39541 agacttggat ttaacagcct ctgtccatta cggagaattg tgtcagcagt ggacgacttg
    39601 gtttcaggaa acgagtgaag atttgattga aacggtagcc tataaactgg tggaacgtac
    39661 ctttgagtct tatcctcttg tccaagaaat gaagttggaa ctgaaaaaac cttgggcacc
    39721 ggtgcatttg tcactagata cttgctcggt aaccattcat cgccgcaagc aacgagcctt
    39781 tatcgcccta ggaagcaata tgggagataa acaagcaaac ttgaagcaag ccattgacaa
    39841 actgcgagct cgtggcatcc atattctcaa agagtccagt gtcttagcga cggagccttg
    39901 gggtggtgtt gagcaggata gctttaccaa tcaagtggtt gaagtagaaa catggttgcc
    39961 tgcccaagtg ctattagaaa ccttgttagc cattgagtca gagctgggac gggtgagaga
    40021 agtgcattgg ggccctcgtt tgattgattt ggacttgctc tttgtggagg accagatcct
    40081 ttatacagac gacctcatat tgcctcatcc ttacatagcg gaacgccttt ttgtccttga
    40141 gtccttacag gaaattgcgc ctcattttat ccatccgata ttaaaacaac cgatccgcaa
    40201 cttgtatgat gctttgaaaa aatagaaaaa ctctagtttt cagttacttg caactgaagg
    40261 ctagagtttt taaaataggt cattttcttc tgggaggagg atagtttctc taccgtccat
    40321 gtctaaaacc agtactcttg ggggataacg agggtcgaaa ggatggttaa agtcaaaatc
    40381 aatggctgta gggaggtgtt gacttgaaaa gtggaaggta atctttcctt ggttattaag
    40441 caattgaaac tcgaattctt cttccaattc aaagacattt tttaagaaat gatcgatgat
    40501 ataccaaaaa gagtcaatga tgtcatcggg caagctggta acaatgccaa aactagcaga
    40561 ccgcatgtgg gtattggtaa aagccatatc tctgtcccct ttcttttccc ttatcataca
    40621 gcaaatagga ttaaaaatca agaaaaggtg attttttgaa aaggatttta actacaggga
    40681 aaaagaagga aaaaaatccc aaaaatctac cgaagttaat aggtaaattc ccaaattaac
    40741 ttgattatat aactttcagt tactttgaga agttaccgaa aaatattttt catatctatt
    40801 gacttttagg ggtgaaattt ggtatgatag taggcggtat tgtttacccc atttgaaagg
    40861 ccccggaacc ttccaaatac ttttcgatgg gaaggaacac ccatcaccgt aaacaaaaat
    40921 cgaactatat ataggagaaa tcatgaacaa aacaacattt atggctaaac caggccaagt
    40981 tgaacgtaaa tggtacgtag ttgacgcaac tgatgtacca cttggacgtc tttctgcagt
    41041 agttgctagc gtacttcgcg gaaaaaacaa accaacattt acaccacaca ctgatacagg
    41101 tgacttcgtg attgttatca atgctgaaaa agttaaattg actggtaaaa aagcaactga
    41161 taaaatctac tacactcact caaaccaccc aggtggattg aaacaaatct ctgcaggtga
    41221 acttcgttct aaaaatgcag tacgtttgat tgagaaatca gttaaaggta tgcttccaca
    41281 caatacactt ggacgcgctc aaggtatgaa gttgaaagta tttgttggag ctgagcacac
    41341 tcacgctgca caacaaccag aagttcttga catttcagga cttatctaag gaaaggaaca
    41401 ataaagtatg tcacaagcac aatatgcagg tactggacgt cgtaaaaacg ctgttgcacg
    41461 cgttcgcctt gttccaggaa ctggtaaaat cactgttaac aaaaaagatg ttgaagagta
    41521 catcccacac gctgaccttc gtcttgtcat caaccaacca ttcgcagtta cttcaactgt
    41581 aggttcatac gacgttttcg ttaacgttgt aggtggtgga tacgctggtc aatcaggagc
    41641 tatccgtcat ggtatcgctc gtgcccttct tcaagtagac ccagacttcc gcgattcatt
    41701 gaaacgcgca ggacttctta cacgtgactc acgtaaagtt gaacgtaaga aaccaggtct
    41761 taagaaagct cgtaaagcat cacaatttag taaacgttaa ttcgaaagaa ttactatact
    41821 tatacagagc acctttcggg gtgttctttt tttatacttt cttactaaat tggtgcaatt
    41881 gacacagttg ttgcgacttt agtcgcttac aaatgtggct gcaacctgac aaggtcagtt
    41941 acctcaaaac gttaatcaat acgattatat caatgtttca aagcactcaa aggtttgccc
    42001 tatgggtgct tttttctata ctttctaaaa aagttttccc taaaatttgc cctaaaatta
    42061 ccctacttgt ttttaagatg ttggtaggca acttgtccag cagataatgg aactatgttt
    42121 gaagcattaa cataagtttt agttgtaatt gtatcactat gagttaatac ttcagaaatg
    42181 gcttctaagc tcattcctgc ctttttagca agtgtcgctc ctgtatgtcg taatttatga
    42241 ggtgtagcgt gttttaactt tgggtgtcgt ctttttacag agttcatttt gttattgaga
    42301 taatcaacgt gtagagggct atttacatta cctttcgtat ctatataggt aaagactagt
    42361 tgatcggatg tttgcattat accaaatttc gctaactcat atttctgctg ttttttccat
    42421 tctgaaagaa gtgatacaag gtaactagga attgaaaaaa tcgttttctt atttcctttt
    42481 gttgacttta cattcttata tttgtcaagt gcatgcctta agccaatttg agcgtttgcc
    42541 aagtctatgt ttttccaatg tagagcatag gattctgatt ttctatcgct caaaataaag
    42601 gttgtaaaga ataggacata atcttttagt gataatttgt cgttctccaa atcttctcta
    42661 aaagcatcaa accaatcttg taattcttca ctagatagat acaaatcttc ctcatcctta
    42721 gcttcttcta gctttatttt tttacttgct ttaatacgtt ttatgctttt tgataatcta
    42781 tttgattcaa tgtattctaa ttcttcagcc caatcgaaaa ttgagtttac atagcttcga
    42841 ataaccttga aattagcata ttcttcagct ttagcagtca ttaagtttag tacgatttgc
    42901 ttattctgat tcagaaaatt gattgaataa ttaccgaaca ttggtaagat gtgcttcctg
    42961 aaaactattt cagtattatc aatagtaact tgtgttgggg gtttagttgt tgaagttgtt
    43021 tgaccagctt tgtatgaatc ccaccaaata ttattaaaga actcagagaa aagaatatca
    43081 ctagttttaa ggagtgggat atcctctcca ttttcaagtt gatgtatctt tgttagaatt
    43141 tctaattcag cttctttagc ctcctttctt gttttatagc gtttaacaaa gtgatttcct
    43201 taaagatata aatactgatt tcccgcttcc tgtacctcca gcaactagaa tatgaggaca
    43261 cttgatagga ttataattca caccgtatcc taaatctata ttaaggttat ctatctcttg
    43321 cttctggttg tgagattgaa gaactaacct gtcaggtttc ttgtaataga aatggtattc
    43381 cataaaacta ggacgaataa ttttgtattc tagttccagt tcgagtactc cagcaagaac
    43441 atcatcaagt gattgtaccc ttttactaaa ttcatcacca gtaatcagag ctttgataaa
    43501 gatatgcccc ttttgtttgt ctaactcgta ttgtaagatt gcgctcctag agattttttc
    43561 atatcctgag ctatctttat gtgttgtata aaggcggttt gtatgtaata catacaataa
    43621 gctttc
//
LOCUS       DAVHSO010000009        42398 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.009, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000009 DAVHSO010000000
VERSION     DAVHSO010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 42398)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42398)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42398
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.009"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(29..1987)
                     /gene="ftsH"
                     /locus_tag="VVR18_000480"
     CDS             complement(29..1987)
                     /gene="ftsH"
                     /locus_tag="VVR18_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HEU6032065.1"
                     /translation="MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYT
                     ELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTI
                     LPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGG
                     GNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGAR
                     IPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAK
                     KAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNR
                     SDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFV
                     GADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHE
                     AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGR
                     VAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMFGAQNPQKS
                     ISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYE
                     TGKMPEAVEEESHALSYDEVKSKMNDEK"
     gene            complement(2003..2545)
                     /gene="hpt"
                     /locus_tag="VVR18_000481"
     CDS             complement(2003..2545)
                     /gene="hpt"
                     /locus_tag="VVR18_000481"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HEU6032066.1"
                     /translation="MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKG
                     SIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDII
                     DTGQTLKNLRDMFKAREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
                     KENYRNLPYIGVLKEEVYSN"
     gene            complement(2549..3826)
                     /gene="tilS"
                     /locus_tag="VVR18_000482"
     CDS             complement(2549..3826)
                     /gene="tilS"
                     /locus_tag="VVR18_000482"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HEU6032067.1"
                     /translation="MREPDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQK
                     ELEIELILAHVNHKQRIESDWEEKELRKLAAEAELPIYISNFSGEFSEARARNFRYDF
                     FQEVMKKTGATALVTAHHADDQVETIFMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL
                     HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPELEKENPRFRDAILGIGNEILDYD
                     LAIAELSNNINVEDLQQLFSYSESTQRVLLQTYLNRFPDLNLTKAQFAEVQQILKSKS
                     QYRHPIKNGYELIKEYQQFQICKISPQADEEEDELVLHYQNQVAYQGYLFSFGLPLEG
                     ESIQQIPVSRETSIHIRHRKTGDVLIQNGHRKKLRRLFIDLKIPMEKRNSALIIEQFG
                     EIVSILGIATNNLSKKTKNDIMNTVLYIEKIDR"
     gene            complement(3823..5091)
                     /locus_tag="VVR18_000483"
     CDS             complement(3823..5091)
                     /locus_tag="VVR18_000483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class A beta-lactamase-related serine hydrolase"
                     /protein_id="HEU6032068.1"
                     /translation="MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIY
                     FREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQITEWRLNKQGIPVFKLSNHQFI
                     AADKRFLYDQSEVTPTIKKVWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEG
                     REFLHIDQAGWVAKESTSEEDNRMSKVQEMLSEKYQKDSFSIYVKQLTTGKEAGINQD
                     EKMYAASVLKLSYLYYTQEKINEGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKED
                     NKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSAIMGDDWDPKEKLISS
                     KMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYA
                     DSPFILSIFTKNSDYDTISKIAKDVYEVLK"
     gene            complement(5211..5579)
                     /locus_tag="VVR18_000484"
     CDS             complement(5211..5579)
                     /locus_tag="VVR18_000484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HEU6032069.1"
                     /translation="MSKNIVQLNNSFIQNEYQRRRYLMKERQKRNRFMGGVLILIMLL
                     FILPTFNLAQSYQQLLQRRQQLADLQTQYQTLSDEKDKETAFATKLKDEDYAAKYTRA
                     KYYYSKSREKVYTIPDLLQR"
     gene            complement(5572..5838)
                     /locus_tag="VVR18_000485"
     CDS             complement(5572..5838)
                     /locus_tag="VVR18_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001234972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HEU6032070.1"
                     /translation="MRLDKYLKVSRIIKRRTVAKEVADKGRIKVNGILAKSSTDLKVN
                     DQVEIRFGNKLLLVKVLEMKDSTKKEDAAGMYEIISETRVEENV"
     gene            complement(5896..9405)
                     /gene="mfd"
                     /locus_tag="VVR18_000486"
     CDS             complement(5896..9405)
                     /gene="mfd"
                     /locus_tag="VVR18_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000258090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HEU6032071.1"
                     /translation="MVTLLDLFSENDQIKKWHQNLTDKKRQLILGLSTSTKALAIASS
                     LEKEDRIVLLTSTYGEAEGLVSDLISILGEELVYPFLVDDAPMVEFLMSSQEKIISRV
                     EALRFLTDSSKKGILVCNIAASRLILPSPNAFKDSIVKISVGEEYDQHAFIHQLKENG
                     YRKVTQVQTQGEFSLRGDILDIFEISQLEPCRIEFFGDEIDGIRSFEVETQLSKENKT
                     ELTIFPASDMLLREKDYQRGQSALEKQISKTLSPILKSYLEEILSSFHQKQSHADSRK
                     FLSLCYDKTWTVFDYIEKDTPIFFDDYQKLMNQYEVFERELAQYFTEELQNSKAFSDM
                     QYFSDIEQIYKKQSPVTFFSNLQKGLGNLKFDKIYQFNQYPMQEFFNQFSFLKEEIER
                     YKKMDYTIILQSSNSMGSKTLEDMLEEYQIKLDSRDKTNICKESVNLIEGNLRHGFHF
                     VDEKILLITEHEIFQKKLKRRFRRQHVSNAERLKDYNELEKGDYVVHHIHGIGQYLGI
                     ETIEIKGIHRDYVSVQYQNGDQISIPVEQIHLLSKYISSDGKAPKLNKLNDGHFKKAK
                     QKVKNQVEDIADDLIKLYSERSQLKGFAFSADDDDQDAFDDAFPYVETDDQLRSIEEI
                     KRDMQASQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVILVPTTVLAQQHYTNFK
                     ERFQNFAVNIDVLSRFRSKKEQTATLEKLKNGQVDILIGTHRVLSKDVVFADLGLMII
                     DEEQRFGVKHKETLKELKKQVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPV
                     QTYVLEKNDSVIRDAVLREMERGGQVYYLYNKVDTIVQKVSELQELIPEASIGYVHGR
                     MSEVQLENTLLDFIEGQYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRGR
                     VGRSNRIAYAYLMYRPEKSISEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNLLG
                     KSQSGFIDSVGFELYSQLLEEAIAKRNGNANANTRTKGNAELILQIDAYLPDTYISDQ
                     RHKIEIYKKIRQIDNRVNYEELQEELIDRFGEYPDVVAYLLEIGLVKSYLDKVFVQRV
                     ERKDNKITIQFEKVTQRLFLAQDYFKALSVTNLKAGIAENKGLMELVFDVQNKKDYEI
                     LEGLLIFGESLLEIKESKEENSI"
     gene            complement(9406..9975)
                     /locus_tag="VVR18_000487"
     CDS             complement(9406..9975)
                     /locus_tag="VVR18_000487"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HEU6032072.1"
                     /translation="MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIF
                     QADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKI
                     RLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
                     LQSVDKVDDSVNYYLQEKNFEKTMQRYNG"
     gene            complement(10046..11161)
                     /gene="ychF"
                     /locus_tag="VVR18_000488"
     CDS             complement(10046..11161)
                     /gene="ychF"
                     /locus_tag="VVR18_000488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HEU6032073.1"
                     /translation="MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMV
                     EVPDERLQKLTEMITPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREVDAIVH
                     VVRAFDDENVMREQGREDAFVDPLADIDTINLELILADLESVNKRYARVEKMARTQKD
                     KESVAEFNVLQKIKPVLEDGKSARTIEFTDEEQKVVKGLFLLTTKPVLYVANVDEDVV
                     SEPDSIDYVKQIREFAATENAEVVVISARAEEEISELNDEDKKEFLEAIGLTESGVDK
                     LTRAAYHLLGLGTYFTAGEKEVRAWTFKRGMKAPQAAGIIHSDFEKGFIRAVTMSYED
                     LVKYGSEKAVKEAGRLREEGKEYIVQDGDIMEFRFNV"
     gene            complement(11245..11439)
                     /locus_tag="VVR18_000489"
     CDS             complement(11245..11439)
                     /locus_tag="VVR18_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 family protein"
                     /protein_id="HEU6032074.1"
                     /translation="MYQVGNFVEMKKSHACTIKSTGKKANRWEITRVGADIKIKCSNC
                     EHVVMMGRYDFERKMNKIID"
     gene            complement(11504..12640)
                     /gene="dnaN"
                     /locus_tag="VVR18_000490"
     CDS             complement(11504..12640)
                     /gene="dnaN"
                     /locus_tag="VVR18_000490"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HEU6032075.1"
                     /translation="MIHFSINKNLFLQALNTTKRAISSKNAIPILSTVKIDVTNEGIT
                     LIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQN
                     QIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRP
                     ILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDD
                     IETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSME
                     RARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYL
                     IDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN"
     gene            complement(12799..14160)
                     /gene="dnaA"
                     /locus_tag="VVR18_000491"
     CDS             complement(12799..14160)
                     /gene="dnaA"
                     /locus_tag="VVR18_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HEU6032076.1"
                     /translation="MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFL
                     PRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYNYS
                     PKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLG
                     KTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLID
                     DIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQ
                     TITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVK
                     KIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVL
                     ARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKK
                     KIK"
     gene            complement(14373..15131)
                     /locus_tag="VVR18_000492"
     CDS             complement(14373..15131)
                     /locus_tag="VVR18_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HEU6032077.1"
                     /translation="MEKFEMISITDIQKNPYQPRKEFDREKLDELAQSIKENGVIQPI
                     IVRQSPVIGYEILAGERRYRASLLAGLRSIPAVVKQISDQEMMVQSIIENLQRENLNP
                     IEEARAYESLVEKGFTHTEIADKMGKSRPYISNSIRLLSLPEQILSEVENGKLSQAHA
                     RSLVGLNKEQQDYFFQRIIEEDISVRKLEALLTEKKQKKQQKTNHFIQNEEKQLRKLL
                     GLDVEIKLSKKDSGKIIISFSNQEEYSRIINSLK"
     gene            complement(15189..16370)
                     /locus_tag="VVR18_000493"
     CDS             complement(15189..16370)
                     /locus_tag="VVR18_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="HEU6032078.1"
                     /translation="MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNS
                     NNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSE
                     GSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
                     EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAI
                     STKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINI
                     IEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHL
                     EKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLE
                     S"
     gene            16553..17032
                     /gene="rlmH"
                     /locus_tag="VVR18_000494"
     CDS             16553..17032
                     /gene="rlmH"
                     /locus_tag="VVR18_000494"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HEU6032079.1"
                     /translation="MKIKVVTVGKLKEKYLKDGIAEYSKRISRFAKFEMIELSDEKTP
                     DKASESENQKILEIEGQRILSKIADRDFVIVLAIEGKTFFSEEFSKQLEETSIKGFST
                     LTFIIGGSLGLSSSVKNRANLSVSFGRLTLPHQLMRLVLVEQIYRAFTIQQGFPYHK"
     gene            17076..17149
                     /locus_tag="VVR18_000495"
     tRNA            17076..17149
                     /locus_tag="VVR18_000495"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:17110..17112,aa:Arg,seq:tct)
     gene            17315..17440
                     /gene="comC"
                     /locus_tag="VVR18_000496"
     CDS             17315..17440
                     /gene="comC"
                     /locus_tag="VVR18_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence-stimulating peptide ComC"
                     /protein_id="HEU6032080.1"
                     /translation="MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK"
     gene            17461..18786
                     /locus_tag="VVR18_000497"
                     /pseudo
     CDS             17461..18786
                     /locus_tag="VVR18_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000362880.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
     gene            18783..19535
                     /locus_tag="VVR18_000498"
     CDS             18783..19535
                     /locus_tag="VVR18_000498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032081.1"
                     /translation="MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEE
                     YIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNPYAIIVFITSRSEFATLTYKYQV
                     SALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
                     IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRK
                     NLEIVFYEDHRCPISRLKIRKLKDILEKKSQK"
     gene            19587..19658
                     /locus_tag="VVR18_000499"
     tRNA            19587..19658
                     /locus_tag="VVR18_000499"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:19620..19622,aa:Glu,seq:ttc)
     gene            19664..19737
                     /locus_tag="VVR18_000500"
     tRNA            19664..19737
                     /locus_tag="VVR18_000500"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:19698..19700,aa:Asn,seq:gtt)
     gene            complement(19778..20320)
                     /locus_tag="VVR18_000501"
     CDS             complement(19778..20320)
                     /locus_tag="VVR18_000501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="HEU6032082.1"
                     /translation="MQESNKRLKTKRTIENAMVQLLMEQPFDKISTVKLVEKAGISRS
                     SFYTHYKDKYDMIEHYQSKLFHTFEYIFQKHAHHKRDAILEVFEYLESEPLLAALLSE
                     NGTKEIQNFLRNKLHIMLSTDLQKRFMQLNLNTTELEYSSIYLTHALFGVCQTWIAHG
                     KKESSQEITDFLMKMLGDTN"
     gene            20499..21266
                     /locus_tag="VVR18_000502"
     CDS             20499..21266
                     /locus_tag="VVR18_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="HEU6032083.1"
                     /translation="MIGISLIPDLYNIIFLSSMWDPYGQLSDLPVAVVNNDKEASYNG
                     NTMAIEKDMVSNLKENKTLDFHFVDEEEGKKGLEDGDYYMVVTLPSDLSEKTTTLSNI
                     QSTAAYQSLTSEQQTEISDSVSQNSTDSIQSAQSIVALVQDLQGSLENLQNQSSNLST
                     LKNQSNQVSPITSTSLIGLSSGLTEIQGDVTSKLVPASQSIASGVNAYTTGVDKVSQG
                     ASQLSEKNATLTGSLDKLVSGSNTLTQKSSRLTAGVG"
     gene            21270..21689
                     /locus_tag="VVR18_000503"
                     /pseudo
     CDS             21270..21689
                     /locus_tag="VVR18_000503"
                     /inference="COORDINATES: protein motif:HMM:TIGR03057.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            21717..22031
                     /locus_tag="VVR18_000504"
     CDS             21717..22031
                     /locus_tag="VVR18_000504"
                     /inference="COORDINATES: protein motif:HMM:TIGR03062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip family protein"
                     /protein_id="HEU6032084.1"
                     /translation="MAGILVYGGVQLIGLTANHEMRIFILIILTSLVFMSMVTTLATW
                     NSRIGAFFSLILLLLQLASSAGTYPLALTNDFFRSINPWLPMSYSVSGLRQTISINKS
                     FS"
     gene            complement(22132..24684)
                     /locus_tag="VVR18_000505"
     CDS             complement(22132..24684)
                     /locus_tag="VVR18_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HEU6032085.1"
                     /translation="MKSFLKTYRTYFISFIIPVVIMSGVYLSQGIYWNSDNSPLLGDG
                     FHQYVIFDVALRNILHGNSSLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMP
                     DAVYLTTLLKFGLIGLSTFFSLNKLFQSIPQTLKLALSTSYALMSFTVSQLEIKTWLD
                     VFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDF
                     KTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAK
                     QFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIE
                     ALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFL
                     ATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSL
                     NASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNY
                     NGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDK
                     YGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKLNEHTLDNQASFLNQLANVNFDY
                     FSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQK
                     KVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTK
                     TFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQ
                     AQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA"
     gene            complement(24746..26368)
                     /locus_tag="VVR18_000506"
     CDS             complement(24746..26368)
                     /locus_tag="VVR18_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6032086.1"
                     /translation="MLTVSDVSLRFSDRKLFDDVNIKFTEGNTYGLIGANGAGKSTFL
                     KILAGDIEPTTGHISLGPDERLSVLRQNHFDYEDERAIDVVIMGNEKLYSIMKEKDAI
                     YMKEDFSDEDGVRAAELEGEFAELGGWEAESEASQLLQNLNIPEELHYQNMSELANGE
                     KVKVLLAKALFGKPDVLLLDEPTNGLDIQSITWLEDFLIDFDNTVIVVSHDRHFLNKV
                     CTHMADLDFGKIKLYVGNYDFWKESSELAAKLLADRNAKAEEKIKQLQEFVARFSANA
                     SKSRQATSRKKMLDKIELEEIVPSSRKYPFINFKAEREIGNDLLTVENLTVKIDGETI
                     LDNISFILRPDDKTALIGQNDIQTTALIRAIMGDIDYEGTVKWGVTTSQSYLPKDNSA
                     DFAGGESILDWLRQFASKEEDDNTFLRGFLGRMLFSGDEVNKPVNVLSGGEKVRVMLS
                     KLMLLKSNVLVLDDPTNHLDLESISSLNDGLKNFKESIIFASHDHEFIQTLANHIIVL
                     SKNGVIDRIDETYDEFLENAEVQAKVKELWKD"
     gene            26574..27599
                     /gene="trpS"
                     /locus_tag="VVR18_000507"
     CDS             26574..27599
                     /gene="trpS"
                     /locus_tag="VVR18_000507"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HEU6032087.1"
                     /translation="MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLA
                     DQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLV
                     SLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIE
                     QTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDAD
                     TLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLG
                     DVKTKRYLLEILERELGPIRERRIEFAKDMGEVYNMIQKGSERAREVAGQTLSEVKGA
                     MGLHYFN"
     gene            27751..29229
                     /gene="guaB"
                     /locus_tag="VVR18_000508"
     CDS             27751..29229
                     /gene="guaB"
                     /locus_tag="VVR18_000508"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HEU6032088.1"
                     /translation="MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTL
                     NIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPF
                     FLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
                     SENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSFSGLITIKDIEKVIEFPNAAKD
                     EFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDR
                     TLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAR
                     EYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRG
                     MGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGY
                     CGAANLKELHDNAQFIEMSGAGLKESHPHDVQITNEAPNYSM"
     gene            complement(29280..30377)
                     /gene="recF"
                     /locus_tag="VVR18_000509"
     CDS             complement(29280..30377)
                     /gene="recF"
                     /locus_tag="VVR18_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000266665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HEU6032089.1"
                     /translation="MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIY
                     FLALTRSHRTRTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQA
                     RLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQR
                     NTYLKSDQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEEL
                     SISYQSSVNITDKQNLSESFKIALEKSRSRDLFKKNTGVGPHRDDISFYINGMDASFG
                     SQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTF
                     ITTTSLDHLQNLPENLSIFTIQDGKASVNGN"
     gene            complement(30380..30748)
                     /gene="yaaA"
                     /locus_tag="VVR18_000510"
     CDS             complement(30380..30748)
                     /gene="yaaA"
                     /locus_tag="VVR18_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HEU6032090.1"
                     /translation="MEYKLFEEFITLQALLKELGITHSGGAIKSFLSEHSVYFNRELE
                     SRRGKKLRIGDKVDIPDMNIDILLTQPTSEEQDEYQADKVEKERIAKLVKKMNKGVKK
                     DKSKPASSPKSQQAPRFPGR"
     gene            30907..32157
                     /locus_tag="VVR18_000511"
     CDS             30907..32157
                     /locus_tag="VVR18_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEU6032091.1"
                     /translation="MELVHGISTHFIQSKKFKTNKITVRFTAPLSLDTIAGHMLSASM
                     LETANQMYPTSQDLRRHLASLYGTDMSTNCFRRGQSHIIELTFTYVRDEFLSRKNVLT
                     SQILELVKETLFSPVVVDNGFDPALFEIEKKQLLASLAADMDDSFYFAHKELDKLFFH
                     DERLQLEYSDLRNRILDETPQSSYSCFQEFLANDRIDFFFLGDFNEVEIQNVLESFGF
                     KGRKGDVKVQYCQPYSNILQEGMVRKNVGQSILELGYHYRSKYGDEQHLPMIVMNGLL
                     GGFAHSKLFTNVRENAGLAYTISSELDLFSGFLRMYAGINRENRNQARKMMNNQLLDL
                     KKGYFTEFELNQTKEMIRWSLLLSQDNQSSLIERAYQNALFGKSSADFKSWIAKLEQI
                     DKDAICRVANNVKLQAIYFMEGIE"
     gene            32154..33437
                     /locus_tag="VVR18_000512"
     CDS             32154..33437
                     /locus_tag="VVR18_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEU6032092.1"
                     /translation="MTKVVFEEKYYPAVKEMVYRTRLANGLTVALLPKKEFKEVYGSV
                     TVQFGSVDTFVTEVDGDVKQYPGGIAHFLEHKLFEREDSSDLMSAFTNLGADSNAFTS
                     FTKTNYLFSATDYFLENLDLLDELVTSAHFTEASILTEQDIIQQEREMYQDDPDSCLF
                     FSTLANLYPGTPLATDIVGSEESISQINLTNLQENFTKFYKPVNMSLFLVGNFDVERV
                     QDYFESKELKDSDFQEVAREKLFLQPVKLTDSMRMEVSSPKLAIGVRGKREVSEADCY
                     RHHILLKLLFAMMFGWTSDRFQKCYESGKIDASLSLEVEITSRFHFVMLTMDTKEPVA
                     LSHQFRKAIRNFTKDLDITEEHLDIIKREMFGEFFSSMNSLEFIATQYDAFENGETIF
                     DLPKILQEITLEDVLDAGHHLIDDGDIVDFTIFPS"
     gene            33479..34300
                     /locus_tag="VVR18_000513"
     CDS             33479..34300
                     /locus_tag="VVR18_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6032093.1"
                     /translation="MRKKTIGEVLRLARINQGLSLDELQKKTEIQLDMLEAMEADDFD
                     QLPSPFYTRSFLKKYAWAVELDDQIVLDAYDSGSMITYEEVDVDEDELTGRRRSSKKK
                     KKKTSFLPLFYFILFALSILIFVTYYVWNYIQTQPEEPSLSNYSVVQSTSSTSSVPHS
                     SSSSSSSIESAISVSGEGNHVEIAYKTSKETVKLQLAVSDVTSWVSVSESELEGGVTL
                     SPKKKSAEATVATKSPVTITLGVVKGVDLTVDNQTVDLSKLTAQTGQITVTFTKN"
     gene            34311..34856
                     /gene="pgsA"
                     /locus_tag="VVR18_000514"
     CDS             34311..34856
                     /gene="pgsA"
                     /locus_tag="VVR18_000514"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HEU6032094.1"
                     /translation="MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVA
                     SITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRE
                     LAVTGLRLLLVETGGTILAAAIPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
                     YSGYDYFKGSAYVFKGTFGSK"
     gene            34853..35680
                     /locus_tag="VVR18_000515"
     CDS             34853..35680
                     /locus_tag="VVR18_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEU6032095.1"
                     /translation="MKSIIDVKNLSFRYKENQNYYDVKDITFHVKRGEWLSIVGHNGS
                     GKSTTVRLIDGLLEAESGEIVIDGQRLTEENVWNIRRQIGMVFQNPDNQFVGATVEDD
                     VAFGLENQGLSRQEMKKRVEEALALVGMLDFKKREPARLSGGQKQRVAIAGVVALRPA
                     ILILDEATSMLDPEGRRELIGTVKGIRKDYDMTVISITHDLEEVAMSDRVLVMKKGEI
                     ESTSSPRELFSRNDLDQIGLDDPFANQLKKSLSQNGYDLPENYLTESELEDKLWELL"
     gene            35665..36504
                     /locus_tag="VVR18_000516"
     CDS             35665..36504
                     /locus_tag="VVR18_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000510406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEU6032096.1"
                     /translation="MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGS
                     GKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEET
                     VLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGIL
                     AMEPAILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVM
                     EKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKES
                     LNG"
     gene            36497..37291
                     /locus_tag="VVR18_000517"
     CDS             36497..37291
                     /locus_tag="VVR18_000517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU6032097.1"
                     /translation="MDSMILGRYIPGDSIVHRLDPRSKLLAMMLLILIVFWANNPLTN
                     LILFIATGIFIALSGVSLSFFIQGLKSMFFLIAFTTIFQLFFISNGNVLFEFSFVRIT
                     DYALQQAGIIFCRFVLIIFFSTLLTLTTMPLSLASAVEALLAPLKRVKVPVHEIGLML
                     SMSLRFVPTLMDDTTRIMNAQKARGVDFGEGSIVQKVKAMIPILIPLFATSLKRADSL
                     AIAMEARGYQGGKGRIQYRQLKWTLKDTLTILVILVLGCCLFFLKS"
     gene            37350..38168
                     /gene="mreC"
                     /locus_tag="VVR18_000518"
     CDS             37350..38168
                     /gene="mreC"
                     /locus_tag="VVR18_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HEU6032098.1"
                     /translation="MNRFKKSKYVIIVFVTVLLVSALLATTYSSTIVTKLGDGISLVD
                     RVVQKPFQWFDSVKSDLAHLTRTYNENESLKKQLYQLEVKSNEVESLKTENEQLRQLL
                     DMKSKLQATKTLAADVIMRSPVSWKQELTLDAGRSKGASENMLAIANGGLIGSVSKVE
                     ENSTIVNLLTNTENADKISVKIQHGSTTIYGIIIGYDKENDVLKISQLNSNSDISAGD
                     KVTTGGLGNFNVADIPVGEVVATTHSTDYLTREVTVKLSADTHNVDVIELVGNS"
     gene            38168..38662
                     /gene="mreD"
                     /locus_tag="VVR18_000519"
     CDS             38168..38662
                     /gene="mreD"
                     /locus_tag="VVR18_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HEU6032099.1"
                     /translation="MRQLKRVGVFLLLPFFVLIDAHISQLLGSFFPHVHLASHFLFLF
                     LLFETIEVSEYLYLVYCFVIGLVYDVYFFHLIGITTLLFILLGAFLHKLNSVILLNRW
                     TRMLAMIVLTFLFEMGSYLLAFMVGLTVDSMSIFIVYSLVPTMILNFLWITVFQFIFE
                     KYYL"
     gene            38756..39934
                     /locus_tag="VVR18_000520"
     CDS             38756..39934
                     /locus_tag="VVR18_000520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEU6032100.1"
                     /translation="MKKKILASLLLSTVMVSQVAVLTTAHAETTDDKIAAQDNKISNL
                     TAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQ
                     SLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKA
                     ISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLL
                     EQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKV
                     RPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIA
                     CWNDGGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTYIYAD
                     "
     gene            40158..40937
                     /gene="rpsB"
                     /locus_tag="VVR18_000521"
     CDS             40158..40937
                     /gene="rpsB"
                     /locus_tag="VVR18_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HEU6032101.1"
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQ
                     QTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLT
                     NWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDV
                     MYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLA
                     DAIIEGRQGEDAVAVEAEFAASETQADSIEEIVEVVEGDNA"
     gene            41016..42056
                     /locus_tag="VVR18_000522"
     CDS             41016..42056
                     /locus_tag="VVR18_000522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HEU6032102.1"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREK
                     GMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAE
                     GKPANNEEALALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNG
                     GRIGVISVVEDGDEALAKQLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNE
                     SRAMVNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRF
                     MLDNTKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEA
                     EVAATMAAALNN"
BASE COUNT        13296 a         7303 c         7820 g        13979 t
ORIGIN      
        1 aaaagagagg ctccagcctc tctcagggtt atttttcgtc attcattttt gactttactt
       61 catcatagga tagtgcatga gattcctctt ctactgcttc aggcatcttt cctgtttcgt
      121 aaagagcttt aatttgtgta ctatccaatg tttcgtattt caataatgct tctgcaatta
      181 acttgtgagt ttcacgattt gactgaataa tttcagcagc tttatttcgt gcctcattta
      241 ataatgaacg aacctcttca tcaatttcat aagctgtttg ttctgaaatt gatttttgag
      301 gattctgtgc accaaacata gcatggtttc cttcatattg tactgggcca agtttttcac
      361 tcataccgta ctctgtaacc attgcacgtg ccatttgtgt cgcttgttca aagtcgtttg
      421 aagctcctgt agtttggaca ttaaagataa tttcttcagc tacacgtcca cccattaagc
      481 cagctaattg ctctttcata tcttctttag atagaagcat ttgatcctct ttaggaagtg
      541 caatcatgta tccgcctgca cggccgcgtg gtacaattgt aaccttatgg acaacgcgag
      601 cattcgacaa gactagacca acaatggtat gtcctgcctc atggtaagca accaattctc
      661 gttctttttg tgaaactgtc ttatctttct tagaaggtcc agcaataact ctatcttctg
      721 cttcatcaat atctgaagca tcaattatcg atttattgcg acgagcagca actaaagctg
      781 cttcattcaa gacattctct aaatcagcac caacaaagcc tggagtttgt tgagccacta
      841 atttcaaatc aacatcttct gctaaaggct tgttcttagc gtgaactttc aagattgctt
      901 cacgaccttt aacatcagga cggccaacca atacttttct atcaaaacgt cctggacgca
      961 aaagggcagg atcaagtaca tctgaacggt ttgtcgcagc gatgacgata atcccttcat
     1021 ttccctcaaa accatccatc tcaatcaaaa gttggttcaa ggtttgttca cgttcgtcat
     1081 tacctccgcc gagaccaact ccacgttgac gtccaacagc atcaatttca tcgataaaga
     1141 tgatagctgg tgctgctttt ttggcatcct caaaaagaga gcgaacacga ctagctccaa
     1201 ctccgacaaa catttctaca aagtcagaac ctgagatact aaagaatgga acacctgctt
     1261 ctccagcgac tgccttagca agcaaagtct tacctgtccc cggaggtccc tccaaaagaa
     1321 cacctgctgg aatacgggct ccaagttttg tgaatcgttt tggatctttt aagaactcaa
     1381 caacttcaac tagttcttgt ttttcttcct cagctccagc aacatctgaa aatcttactt
     1441 taatatcttc tttatttgct gctttagcct tactacgtcc aaaactcatt ggattacggc
     1501 cattgcctcc tcccatattt cccatcatag agaataggaa gaagaataga attccaaatg
     1561 gcacaatgga tacgagtaga ttaatccata taccacttga actttcatgc ttaacagtta
     1621 cttctgcttt atggtcagta gcaagttttt gcaattctga tacggtagta tctgcaggaa
     1681 gaatagtgct ggtaaatttc tctaccttag taacagatgg cgtgaaaaac tgaatacctg
     1741 ttccttcttt acttgtttta ggatttttat agacaccaga aacttcgata acactaccat
     1801 ttggttggta agttaattct tttacattac catcggtaat ttcttgtacc aactcagtat
     1861 agttgatttg ctgacttcct cctgagttat tcccagaata gaaatactgg aatcctgtca
     1921 caaggaaaaa gataaataat aaccatagaa aaggattttt aattaaacca ttattttgtt
     1981 ttttcattaa agattattct ttctaatttg aatacacttc ctctttcaat actccaatat
     2041 aaggaagatt acgataattt tctttgtagt ctaaaccata acctactaca aactcatttg
     2101 ggatagtaaa gcaggtatag tctgcctcaa tttctacaac acgtccttct ggtttatcca
     2161 acaaggttgc aattttaaca gaagctgctt ctcttgcttt aaacatatct cgcaaattct
     2221 tcaaagtttg acctgtatca atgatatctt ctacaaatag aacatgtctt cctttgatat
     2281 cttgagtcac atcttgttta atattgataa caccactact tgctgttcca ccatggtagc
     2341 tagaaaccat catgaagtcc atttcaatat gtgtatcaat atgtttgacc aattcagcca
     2401 taaaaggaat agatcctttt aaaatcccaa ctaagattgg attttttcct gcataatctt
     2461 tagttaattg agcacctagt tttttagctg cttctgtaat ttcatcgtgt gaaacgagga
     2521 cttttttaat atcgttttct aacatttttt acctatctat tttttctata taaagtacag
     2581 tgttcattat atcatttttc gtttttttac tcaaattatt ggtcgcaatt cccaaaattg
     2641 agacaatttc accaaattgc tcaataataa gagcagagtt tctcttttcc atagggattt
     2701 tcaaatcaat aaataaacgt ctgagttttt ttctatgccc attttgaatc aaaacatctc
     2761 ctgtttttcg atgacgaatg tgtatggatg tttcacgtga aacaggtatt tgttgaattg
     2821 attcaccttc taatggaagt ccaaaggaaa ataaatatcc ttgataagct acctgatttt
     2881 gatagtgtaa cacaagttca tcttcctctt catcagcctg cggactgatt ttacaaatct
     2941 gaaactgttg gtactctttt atcaattcat agccattttt aatcggatga cgatactggc
     3001 ttttagattt taaaatctgc tgaacttcag caaactgagc ttttgtaaga ttcaaatctg
     3061 gaaaacgatt cagataagtt tgaagtaaaa ctctttgtgt agactcagag taagaaaata
     3121 actgctgtaa atcttccaca ttaatattgt tagataattc agctattgcc aaatcataat
     3181 ctaaaatttc attgccaatg cctaagattg catccctaaa tcgaggattt tctttttcca
     3241 attctggtaa gtaagaattt cgaatacgat ttcgaaaata atgattctcc tgatttgatg
     3301 tatcttcaaa gtgaaaaatt gatggaaagt cttttttctg aaaatgcaag aagggacgaa
     3361 tgatttctat ctctccgact acttgcttct ccttaattcc tgatagatag cgcaagcgag
     3421 ttcctcgaat caagcgcata aaaatcgttt ccacctgatc atcagcatgg tgggcagtga
     3481 ctaaagctgt cgcacctgtc tttttcatga cctcttgaaa aaaatcataa cgaaaatttc
     3541 gtgcacgcgc ttctgaaaat tctcctgaaa aattgctgat ataaatagga agctctgctt
     3601 cagcagccaa cttccttaat tccttttctt cccaatctga ttcaattctc tgcttatgat
     3661 tcacatgagc tagaatcaat tcaatctcta actctttttg ataagtagac aataccttaa
     3721 atagaaacat agaatctaat ccaccagaaa gagctagaac cgccttagca tgctttttga
     3781 aatatccctt cttgagaaaa tgatttaaaa aatctggttc cctcatttta gaacctcata
     3841 aacatccttg gctatcttag aaatcgtatc ataatcagaa ttcttagtga aaatagaaag
     3901 aataaatgga gaatctgcat agacaacacc cgtatcatgc ttaaattcat ccgcatctcc
     3961 aattttatga gctactttaa cagaaacacc tttggcaatt cgctgactat caaaatctgt
     4021 tttagtcaaa gactctagca caaatccatt ttgattataa atagcttcca taaacttccc
     4081 ggccatctta gaagaaatca atttttcttt tggatcccaa tcatctccca taatggcaga
     4141 catcttggat ttgaatgtgg catcagattg gtttgaaatg taatatccca atagattatg
     4201 agctacatta tcagattctt ttgatacttt cgtaattaaa tcctttaaag aatattcttt
     4261 attatcttct tttttaggaa gactaccact tccctctggt ttataagaac ctggaaaatc
     4321 attgactgca gatacgtatt ttacagtcgt atctaactga taaagaccct catttatttt
     4381 ttcttgcgta taatagagat aagagagttt caaaacgctg gctgcataca tcttttcatc
     4441 ttgattgata ccagcttctt ttccagtagt cagttgctta acataaatag agaaagaatc
     4501 tttctgatat ttttcagata acatttcttg aactttactc atccgattat cttcttcaga
     4561 agttgattct ttagctaccc atccagcctg atcaatatgt agaaattctc ttccttctac
     4621 aaacatggtc ttgtcgattg atacttgcga ataagctgat aaggatgatt tcacttcttt
     4681 taaatcataa ggactattgt acagtttaaa gtcagattct aaccatactt tttttattgt
     4741 tggagttacc tctgattgat catataaaaa tcgtttgtcc gcagctataa attgatgatt
     4801 tgatagctta aatactggaa ttccttgttt atttaagcgc cactcggtta tttgaaaact
     4861 tgttttggga gtcaatttcc cagattccac tactaaatct tcattcgcat aaacaggaac
     4921 ctctccataa accatgggag aacttaattt ttctctaaaa taaataccaa agtcagattg
     4981 tgaaaggtaa taaatttctt tcgaagtata gacgacttct ttttctgtgc taacgacttt
     5041 tgaaatggtc aaaaaacttg gtagcaacaa aataattaag aatttacgca ttcttccttt
     5101 ccttttcttc ttgtaaacgc aataattgat ttttatcagc caattcttcc agcttttcat
     5161 ctgacaaact caaaaattgc tctattacgt ctaataaatt ttccatttta tcacctttga
     5221 agcaagtcag gaatcgtata aactttttcc ctcgacttag aataatagta cttcgctcgt
     5281 gtatatttag cagcataatc ttcatctttc aacttggtag caaatgctgt ctccttatcc
     5341 ttttcatcac tcaaagtttg atactgagtt tgcaagtctg ctaattgctg acgtctttgg
     5401 agtaattgct gataactctg cgctaaatta aaagttggca agataaataa tagcataatc
     5461 aaaatcaata cccctcccat aaaacgattc cgtttttgtc gttctttcat caggtagcga
     5521 cgacgttggt attcattttg aataaaagaa ttattcaatt gtacaatatt tttagacatt
     5581 ttcttctacc cgtgtttcac tgataatttc atacattcct gctgcatctt ctttttttgt
     5641 actatctttc atctctagta cttttacaag cagcaactta ttgccaaagc gaatttcaac
     5701 ttggtcatta actttcaagt ccgttgaact tttggccaag attccattaa ccttgattct
     5761 acctttatct gctacttcct ttgcgactgt acgacgcttg ataattcgcg atacttttaa
     5821 atatttatct aatctcatcc ttattacctc aatttattat tgtaccattt ttatctattt
     5881 tatagaagaa aaatatcaaa tggaattttc ttccttagac tcttttatct ctaataaact
     5941 ttctccaaaa atcagcaaac cttctaaaat ttcataatct ttcttatttt ggacatcaaa
     6001 tacaagctcc attaatccct tattctcagc gatgcctgct tttaagttcg ttacggataa
     6061 agctttaaaa taatcttgag ctaaaaacag tcgttgagtg actttttcaa attgaattgt
     6121 aattttatta tcttttcttt ccacacgttg aacaaagacc ttgtccaagt atgatttgac
     6181 caaaccaatc tctaacagat aggctactac atctgggtat tctccaaaac ggtctatcaa
     6241 ctcctcttgt aactcttcat aattgacacg gttgtcaatt tgacgaattt tcttgtaaat
     6301 ttcaatctta tgtcgttgat cagaaatata agtatcagga agataggcat caatttgcaa
     6361 aatcaactca gcattccctt tggttcttgt gttagcgtta gcattaccgt ttcgtttagc
     6421 aatagcttcc tctaataact gcgaatacaa ttcaaaacca acagaatcaa tgaaaccaga
     6481 ctgggatttt cctaaaagat ttcctgctcc acgaatcgaa agatctcgca ttgcaatctt
     6541 aaagccagag cccaattctg taaatccttt aatcgcttct aatctctttt cagagacttc
     6601 actgattgat ttttctggac gatacatgag ataagcataa gcaatacgat tactacgacc
     6661 gactcttcct cttaactgat ataaggttga caagcccata tggtccgcat tttcaataaa
     6721 taaagtatta gcatttggaa tgtccacccc tgtctcaata atagtagtcg tcaccaagat
     6781 atcgtattgt ccctcaataa agtctaatag agtattttcc aactggactt cactcattcg
     6841 accatgaaca tatccaatcg aagcctccgg aatcaactcc tgtaattctg aaaccttctg
     6901 aacaattgtg tcaactttgt tgtaaagata ataaacttga cctccacgct ccatttcacg
     6961 caagacagca tcacgaatga cactatcatt cttttccaaa acataggtct gaacaggata
     7021 gcgattagtc ggcggagttt caataacaga taaatctctg attcccagca tagacatatg
     7081 gagggtacga gggattggcg tagcggtcaa ggttaggaca tccacttgtt tcttcagttc
     7141 tttcaaagtt tccttatgct tgacaccaaa tcgctgttcc tcatcaataa tcatcaagcc
     7201 caaatcagca aacacaacat cttttgacaa aacacgatgt gttccaatca aaatatcgac
     7261 ttgaccgttt ttcaattttt caagtgttgc agtctgctct tttttacttc taaagcgact
     7321 caacacatca atattaactg caaaattttg gaatcgttcc ttaaaattcg tatagtgctg
     7381 ttgcgctaaa accgtcgtcg gaactagaat gacaacctgt ttgtgatcat tgactgcttt
     7441 aaaggctgca cgcatagcaa cttcagtctt tccaaaacca acatccccaa ctaaaagtcg
     7501 atccattggc tgagaagcct gcatatccct cttgatttcc tcaatactac gaagttgatc
     7561 atccgtttca acataaggga aagcatcatc aaaggcatct tgatcatcat catcagctga
     7621 gaaagcaaaa cccttcaact gactacgttc agagtagagt ttgattaaat catcagctat
     7681 atcctctacc tggttcttaa ccttttgctt ggccttttta aaatgaccgt catttaattt
     7741 attgagtttt ggagctttac catcacttga aatatatttg gacagtagat gaatctgttc
     7801 cacggggata gaaatttgat caccattttg gtattggaca ctgacataat cgcgatgaat
     7861 tcccttgatt tcaatggttt caattcctag atattgacca atcccatgga tatgatggac
     7921 aacatagtcc cctttttcaa gttcattgta atcttttaat ctctctgcat ttgaaacatg
     7981 ttgtcttcga aaacgacgct ttaatttctt ttgaaaaatc tcatgttcag ttatcaataa
     8041 aatcttttca tctacaaaat gaaaaccatg tctgagatta ccctctatta agtttacaga
     8101 ttctttacag atgtttgtct tatctctaga atccaattta atctgatatt cctctaacat
     8161 atcctccaat gttttacttc ccattgaatt gctagactgc agaataatgg tgtaatccat
     8221 ttttttatat cgttcaattt cttcttttag aaaagaaaac tgattgaaaa attcctgcat
     8281 aggatattga ttgaattgat aaattttgtc aaatttgaga tttcctaaac ccttttgaag
     8341 attagagaaa aaggtcactg gactttgttt tttatagatt tgttcaatat cagaaaaata
     8401 ctgcatatca gaaaatgctt tactattctg taattcttct gtaaagtact gcgctaattc
     8461 tctttcaaag acttcatact gattcatcaa tttttgataa tcatcaaaga atattggagt
     8521 atctttttca atataatcaa agacagtcca tgtcttatca tagcacaaag ataaaaactt
     8581 ccgagagtct gcatgacttt gtttttggtg aaaacttgaa agaatttctt ctaggtatga
     8641 tttcaaaata ggtgataaag tttttgaaat ttgtttttct aaagctgact gtcctcgttg
     8701 ataatccttt tctctcaaaa gcatatcact agctggaaag atagtgagtt ctgtcttatt
     8761 ttctttcgat aattgtgttt ctacttcaaa tgacctgata ccatcaattt catcaccaaa
     8821 aaactcaatt cgacaaggtt ctaactggga tatttcaaaa atatctaaaa tatctcctcg
     8881 aagactaaat tcgccctgag tttgtacttg agtaactttt cgatagccat tttcctttaa
     8941 ctgatggata aacgcgtgtt gatcatattc ttcaccaact gagattttta caatactatc
     9001 tttgaatgca ttgggagacg gtaaaatcaa tcgacttgct gcgatattac aaactaaaat
     9061 ccctttctta gatgaatcag tcaaaaaacg caaggcttca acccgtgaaa taattttttc
     9121 ctgtgaagac atcaaaaact ccaccatagg agcatcatct accaaaaatg gatagacgag
     9181 ttcctcaccc aagatagaaa taagatcact aacaagtcct tctgcttctc cataagttga
     9241 cgtcaataac acaatcctat cttctttttc taaactgctt gcaattgcaa gagccttagt
     9301 agatgttgat aaaccaagta ttagttgtct tttcttatct gttaaatttt gatgccattt
     9361 tttaatctga tcattttctg agaataaatc taataaggtc accatttatc cgttatacct
     9421 ctgcattgtt ttctcaaaat ttttctcttg taaatagtag tttacagaat cgtcaacttt
     9481 gtcaacagac tgtaaaatac cgatataatc atccctgtca aacttactca aaacatgatg
     9541 aacaactgac ataccatttt taggtcttcc aattccaatc ttaacacggt taaagacctg
     9601 agttcctata tgttgaataa tagacttgat accattatga ccacctgctg agccttttgc
     9661 tcttaaacga attttcccaa cttccatgtc aagatcatcg taaatgataa gtaaatcgtc
     9721 aatatccaaa ccatagtaag ttaataaagc atgaactgct tttccacttt cattcataaa
     9781 ggtcgttggt ttaaccagat aaattttttc tccatttagg aaaaaggatg ctaggtcagc
     9841 ttgaaatatc ttatcgtgtg taaaagtgac attctgtttc ttcgctagtt gatcaatcaa
     9901 cataaaacca acattgtgtt ttgtttcaaa atatttatcc cctggatttc ccaagcctac
     9961 aagtaatttg gtcatttatt tttcctttca aaagccaaaa gggttggaat ttttttccaa
    10021 cctaattgac accatttatt aatttttaga cattaaagcg gaattccatg atatcgccat
    10081 cttgaacgat atattctttt ccttcttcac gcaagcgtcc agcttctttt acggcctttt
    10141 cagatccgta tttcactaga tcttcatatg acatggttac tgcacgaata aagccttttt
    10201 caaagtctga gtggataata ccagctgctt gaggagcctt cataccacgt ttgaaagtcc
    10261 aagcgcgaac ttctttttca ccagctgtga agtaagttcc caatccaagc aagtggtaag
    10321 ctgcacgcgt caacttatct acacctgatt ctgtcaaacc aatggcttca agaaactctt
    10381 ttttatcttc atcattcaat tcagaaattt cttcctcagc acgcgcagaa ataacgacta
    10441 cttcagcatt ttctgtcgct gcaaattcac gaatttgttt gacatagtcg atagagtcag
    10501 gttctgaaac cacatcctcg tccacattag ctacataaag aactggttta gtcgtcaaaa
    10561 ggaaaagacc tttgacaacc ttttgttcct catctgtaaa ttcaatggta cgagctgatt
    10621 tcccgtcttc taggactggt ttaatctttt gaagaacatt gaattctgct actgattctt
    10681 tatctttttg cgtacgtgcc atcttttcta cacgcgcata tcgtttgttc actgattcta
    10741 agtcagcaag aattaattcc agattaattg tatcaatatc tgcaagtgga tctacaaagg
    10801 cgtcttcacg tccttgctcg cgcatcacat tttcatcatc aaaagcacga actacgtgaa
    10861 caatcgcatc tacttcacga atattggcca agaatttatt ccctagccct tctccttttg
    10921 aagctccttt tacaatccct gcaatatccg taaattcaaa tgttgtggga actgtttttt
    10981 taggagttat catttcagtt agtttttgta ggcgttcatc tggaacttcc accattccaa
    11041 catttggatc aatcgtcgca aatgggtagt ttgctgcctc tgctcctgct tttgtaattg
    11101 cattaaatag tgttgattta ccaacgtttg gcaaaccaac gatacctgct gtcaaagcca
    11161 tatttctcat tctccgtttt catttcaatc cctaatatta taacacaaaa agggataaag
    11221 tgctaaccct ctaactaagg gttctcagtc aataatttta ttcatttttc gctcaaaatc
    11281 atatcgcccc atcatgacaa catgctcaca attactgcat tttattttga tatctgctcc
    11341 tacacgtgta atttcccaac gattagcctt tttaccagtc gacttgattg tacaagcgtg
    11401 tgattttttc atctcaacaa aatttccaac ttgatacata ctactctcct tttctttttc
    11461 gattatatca taaaagaggc gagccaggct caacctcttt cacttaattt gtacgaactg
    11521 gtgtaatgag ctgcatgaag tcttcgtcag tatctgctgg cacaagagta aatggacgaa
    11581 cagctgagat aaagctaatg gtcacctttt cgctatttaa agctttaaga gaatcaatca
    11641 agtaagttgg gttgaaacta atggtcaaat cttcaccagt aacctgatca gtatcgattt
    11701 cttcgtttac tttaccaact tctggagagt gaacatgggc gctaacaacc ccatccttaa
    11761 tttcaagttt cacagtacca ttttgagtcg cacttgataa aagacgggca cgctccattg
    11821 actggcgtaa gtttaccaca ttaaaagtaa tagtagtgtt aaagtctgtt ggaatcaagc
    11881 gatctgtatc aggatagttt ccttctagga gacgagtata gaagctaata ttttcgcttc
    11941 taaagaggat ttggttattg gcaaagaaaa tctctacagt ttcgatatca tctgtaaata
    12001 ccgctgaaaa ttcgcgtaga gaacggctag gaattacgac atcaaaatca tcactatttt
    12061 tttcaagagt caattttttc tggcttaggc gatgagagtc tgttgcaact gtttttaact
    12121 ctttgtgttg actcaatacg aagtggacac ctgttaaaat cggacgactc tcttgtgtac
    12181 ttgcagcaaa ggctgtttca ttaataattt tcttgagtaa ttttgtttca agtattaaag
    12241 gagtgcttgc tgaaatttct tggattcgtg gatattgttc gctatctttt ccttttaggg
    12301 taatttctga tttgccactg gttaaaacaa tttgattttg ttcaatttct ttaaaatcaa
    12361 gagttacatc aggtaaacta gatactacat tgataaagaa agaagcttca agaaggatcg
    12421 aacctaaaga agtaattaac aaaccagcat cttcattttt ttgagaaata aaattttcaa
    12481 ttgaaatttg accatttgaa ccaattaaag taataccttc attggtcacg tcaattttta
    12541 ctgttgataa aataggaatg gcatttttag aactaatagc tctcttagta gtatttaatg
    12601 cttgtagaaa taaattttta ttaattgaaa aatgaatcat ggattctcct ttatttattt
    12661 ttagtattag aaagataata gtaataatag agtctgtgaa atctgtggaa aacagccttt
    12721 aaacaagtca tatcaagttt tttagcttgt ttaaaaaatg tggataaaaa agataaaaaa
    12781 ctaaaagtta tccacaaatt atttgatttt ctttttgatt gattcaattt ctaaacgtaa
    12841 attatcgtct tgatcaatca aagattttat tttggcatgg gcatgaatga ctgtggtatg
    12901 atcttttccc ccaaattcct tcccaatttt tggaagacta ttatctgtta gttctctaga
    12961 taaatacatg gctacttgac gggccaaaac aatattttga aggcgtctac ttcccttcat
    13021 ttctttgata ctaacaccat aaaagttacc aacttcagtt tggattttat caattgggat
    13081 gacgagcatt tggctaacat cttgtttgcg ggctctaatg gcttctgcag caatatcaat
    13141 agtgatatcc ttgatttttt ttactctggc aattaaagtg atgtcgttga tggctccctc
    13201 aagatctcga acatttgaat caaattgccc agctaggtat tctagagtat cactttggaa
    13261 attgtagcct aaatgttccg ttttactttg taaaatggca atacgtgttt caaagtcagg
    13321 gggtgtgata gtttgtgtca atccccaact aaaacgcgtg acaagcctct cctcgagccc
    13381 ttctagatgt tttggactac gatcactcgt taggacaatc tgtttttgct tgtcatgaag
    13441 ggcgttaaag gtattgaaaa attcttcctg agttgcgact ttttttccgc tgagtgactg
    13501 gatatcatcg attaacaaaa gatcaagact acgataggtc tttttaaact tttccatttc
    13561 cccaagtctt aggtgatcaa gaaagtcatt aataaagctt tcggcaggga tatatttaac
    13621 acgcgcatta ggaatatttt ttagaatttc atttccaata gcgtttaata agtgagtctt
    13681 accaaggcct ggtcctccat agataaaaag agggttatag gtcagagcca aatcttcaga
    13741 gacagctaaa gcggctgaca cagcccaaac atttccatcc ccttgaataa agttatcaaa
    13801 ggtatacttt tcttttaatc ccgtatctga ataaggaata gatactaact ttggactata
    13861 gttataaaga gttaaatttg tagcttcttc aacttgtgag ctagtcgtat cttgaggttt
    13921 ggtgaaaata tagtggggag ttatttcagc gtcataaatt tcaaaaccag ctactacaat
    13981 aatatctttt agttgttttt cccagaccat ttccatttca gagcgaggta gaaatatagt
    14041 ggcaacattt tcctctacct tgatgagttc agcttgaata gcatagaaat catacatgga
    14101 tcgagtcagt ctttcttgtg caaattctaa tatacgattc caaaattgtt tttctttcaa
    14161 tcctttctcc tcctttacta tttaaaagtt taatactaga gatattttac catagatagc
    14221 aagaattttc cacaagctgt gaaaaataat ccacaatgtt accaaacttt atccacaggt
    14281 tggggataaa agaagaaatt attgatttat taagcttttt atcgaaaaac atagtggata
    14341 accttgtgag ataaaaaaat aaaagaacag ccttatttca ggctgttgat aattctacta
    14401 tattcttctt gatttgaaaa agaaataatg atttttccac tgtctttttt agatagttta
    14461 atttctacat ctaatccgag tagttttctt aactgttttt cttcattttg tatgaaatga
    14521 ttagtttttt gctgtttctt ttgttttttc tctgtcagaa gagcttctaa cttccttaca
    14581 gaaatatctt cttctataat ccgttgaaag aaatagtctt gttgttcctt atttaaccca
    14641 actagggaac gcgcatgggc ttgtgatagt ttgccatttt ctacttctga gagaatctgt
    14701 tctggcaagg aaagtaaacg aatggagttg ctgatatatg gacgagactt gcccatctta
    14761 tctgcaattt cagtatgggt gaatcctttc tctacgagag attcataggc gcgtgcttct
    14821 tctatcgggt ttaaattttc tctctgtaaa ttttcaataa tggactggac catcatctct
    14881 tggtctgaaa tctgtttaac aacagctggg atagaccgta gaccagctaa aagtgaagcc
    14941 cgatagcgtc tctctcctgc aaggatttca taaccaataa caggagattg acgaacaata
    15001 atcggttgaa tgaccccatt ttctttgata gactgtgcta gttcatctag tttttctcta
    15061 tcaaattctt ttcggggttg atagggattt ttttgtatat ctgtgataga aatcatttca
    15121 aatttttcca tgattctaca ctaacacatc ttttctctta tgtaaagctt tctttacata
    15181 gatgtcaatc aagattctaa atcacctgaa ctcttgttaa gtttgataga ggtagtttct
    15241 tctttcccgt tacgatagta ggttatctta atggtgtctc cgatagaatg gttgtaaaga
    15301 gcactttgta agtctgttga tgaagcaatc tctttgtcat ctacttttgt aattacatcg
    15361 tatttttcaa ggtgaccatt ggcaggcata ttactttgta ccgaacgaac aactacacca
    15421 gatgtaacat tacttggaat attgagtctt ctgatgtcgc ttgtactcac attagataaa
    15481 ttaaccatct ggattcccaa agctggacgc gtcacttttc cgtttttttc taactgttca
    15541 ataatattga tagcatcatt tgcaggaatt gcgaaaccaa gaccttctac agatgttcct
    15601 ccatttgtag caattttact tgaggtaatt ccgataacct gcccttgaat attgatcagt
    15661 gggccgccag agttacctgg gttaatagca gtatcagttt ggatggcttt tgtagaaata
    15721 gcttgtccat cttccgattt taaggataca tttctattga gactggatac gataccttga
    15781 gtgacagtat ttgcatattc agaacctaac gggctaccga tggcaatagc agtttctcct
    15841 acagttaact tactagaatc accaaactca gctactgttg tcactttttc tgaagagatt
    15901 tttacgacag caatatcaga gaaagtgtca gctccgacaa tttctccagg tactttagtc
    15961 ccatctgaca atcgaatatc tactttgctg gcgccattta taacgtgatt gttggtgacg
    16021 atgtaagctt ctttatcatt ctttttataa ataactccag atccttcact agagattcgc
    16081 tgagaatctg tgtcagtatc atcattgcca aatacgctat tttgtctgtt tgccgaataa
    16141 gtaataacag aaacaacagc atcttttact ttgttaacag cctgtgttgt tgaattttcg
    16201 ttcttatagg cagtttgtgt aatagtacta ttgttgttag agttgtttac actacttttt
    16261 tgagttagtt gagttattga aaaactaccc aaggctccac taaaaaagct aatgacgata
    16321 acgactaata attgaaacca ttttttgtaa aatgttttta gatgtttcat atttgcctcc
    16381 atatgtttga attactgaaa gtataaactg actagcttaa ttataactta aacacaaaag
    16441 ttttacacaa actgtggata actcttttga aactgtgatt ttcttaattg aaatctattt
    16501 tttattttgt gaataagatg tgaaaaaata gagaatatgt tagaatagag tcatgaaaat
    16561 taaagttgta acagttggga aactgaaaga aaagtattta aaagatggta tcgcagagta
    16621 ttcaaaacga atttctagat ttgctaagtt tgaaatgatt gagttatcag atgaaaaaac
    16681 accagataag gccagtgaat cagaaaatca aaagatttta gaaatagaag gtcagagaat
    16741 tttatcaaaa attgctgacc gtgatttcgt tattgtgtta gccattgaag ggaaaacttt
    16801 cttctcagaa gaatttagta agcagttaga agaaacttct ataaaaggat tttctactct
    16861 tacttttatt attgggggaa gtttaggatt gtcatcatct gtaaaaaata gagccaatct
    16921 ttctgtcagt tttggtcgcc taaccttgcc tcatcagtta atgagactag ttcttgttga
    16981 acaaatctat cgcgctttta cgattcagca gggattcccc taccataaat agaaaattga
    17041 cttttaattg aatttttggt agaataattg tgttaggtct catagctcag ctggatagag
    17101 cattcgcctt ctaagcgaac ggtcgcaggt tcgaatcctg ctgggatcaa tataatagca
    17161 aagctgggaa ttttcccggc ttttttctta aaaaagtaca ctttgggaga aaaaaatgac
    17221 agttgagaga attttatcta aaacgaaatt ccattttgta taatggtttt tgtaagttag
    17281 cttacaagaa aaaaacattt taggagattt tattatgaaa aacacagtta aattggaaca
    17341 gtttgtagct ttgaaggaaa aagacttaca aaagattaaa ggtggggaga tgaggctgtc
    17401 aaaattcttc cgtgatttta ttttacaaag aaaaaagtaa tgaaataagg ggaaagagta
    17461 atggatttat ttggatttgg gacagttatt gttcattttt taattattag tcacagctac
    17521 catttaattt gtaaaggtca aataaataga aaagaattat tcgtttttgg tgcttataca
    17581 ttactaacag aaatagtatt tgattttccc ttatatattc tatatttaga tgggttaggg
    17641 attgcaacat ttttatttcc tttgggccta tattcctatt ttcgatggat aaaacagtat
    17701 gagagggata gaggactatt cctaagttta ctactatctc ttttatatga gagcactcat
    17761 aactttctgt ccgtaacttt ctcctctata acaggagata attttgtttt acaatatcat
    17821 ttcccattct ttttcgttgt gacggtgttg acctattttg ttacattaaa aatcatttat
    17881 tatttccatt tggaactagc ctattttgac aaggactacc tttatccttt cttgaaaaaa
    17941 gtattttttg ctttactatt gctacatatt gtatctttcg tttcagatat ggtaagtacg
    18001 attaaacatt tgaatagttt tggaagtatt ttgtcatcta ttgtctttat ctctctcctt
    18061 ttgaccttct ttgcaatgaa ttctcataaa gttcaaatgg agaaagagat tgctttgaag
    18121 cagaagaaat ttgaacagaa acatttacag aattacacag atgaaattgt cggtctgtat
    18181 aatgaaatcc gtggttttcg acatgattat gctgggatgc ttgtcagtat gcagatggca
    18241 attgacagtg gtaatttaca ggaaattgac agagtttaca atgaagtttt ggtcaaagca
    18301 aatcataaac tgcgttcaga taagtacact tactttgatt tgaacaacat agaagattca
    18361 gctttacgaa gtttggttgc tcagtcaatt gtctatgctc gaaataatgg tgtagagttt
    18421 acactggaag taaaagatac gattaccaag cttccaattg aactattgga tttggttcgt
    18481 atcatgagcg ttttattgaa taatgctgtc gaaggatcgg ctgatagcta taaaaagcag
    18541 atggaagtag cagttattaa gatggaaact gaaacagtta ttgtgattca gaattcatgt
    18601 aaaatgacga tgactccttc aggagatcta tttgccttag gattctccac taagggaaga
    18661 aatcgcggag tctgattaaa taatgtgaaa gaactactag ataagtacaa caatattatt
    18721 ttagaaacag agatggaagg cagtacattt agacaaatca ttagatttaa gagggaattt
    18781 gaatgaaagt tttaatttta gaagatgtta ttgaacatca agtgagacta gagagaatat
    18841 tggatgaaat ttcgaaagaa tcgaatattc caatatcata caagacaacg ggaaaagtcc
    18901 gtgaatttga agaatacatt gaaaatgatg aagtaaatca actttatttc ctagatatcg
    18961 atattcatgg aattgagaaa aagggatttg aagtggctca gctcattcgt cattacaatc
    19021 cttacgctat tatcgtcttt atcactagtc gatcagagtt tgcgactcta acctataaat
    19081 accaggtatc agccctagat tttgttgata aggatatcaa tgatgagatg tttaagaaga
    19141 gaattgagca aaatatcttc tacacgaaga gtatgttact tgaaaatgaa gatgttgtag
    19201 attatttcga ctacaattac aagggaaatg atttaaaaat tccttaccat gatattttgt
    19261 atattgaaac aacaggggta tctcataaat tgcgcattat tggtaagaat tttgcaaaag
    19321 agttttatgg taccatgaca gatattcagg aaaaggacaa acatactcag cgattttatt
    19381 ctcctcacaa gtcatttttg gtaaatatag gcaatatcag agaaattgat cgaaaaaact
    19441 tagaaattgt tttctatgaa gaccatcgtt gtcctatttc aagattaaaa attagaaaat
    19501 taaaagatat tttagagaaa aaatctcaaa agtgattgac aattagcaag aaattgatat
    19561 aatggttata tctgctacag atagaaggtc cgttggtcaa ggggttaaga caccgccttt
    19621 tcacggcggt aacacgggtt cgaatcccgt acggactatt ttatccgcca tagctcagtt
    19681 ggtagtagcg catgactgtt aatcatgatg tcgtaggttc gagtcctact ggcggagtat
    19741 agataaaagg gaacacagct gtgttcctct ttttgtatca atttgtatca ccaagcattt
    19801 tcataaggaa gtctgttatt tcttgagaac tttctttttt tccatgtgca atccaagttt
    19861 ggcagacacc aaaaagtgca tgagttagat agatgctact atattctaat tcggtggtat
    19921 ttagattcag ttgcataaat cgcttttgta aatctgtact aagcatgata tgaagtttat
    19981 ttcgtaagaa attttggatt tctttagtcc cattttcaga aagaagggca gccagaagtg
    20041 gttctgactc tagatattca aaaacttcta aaatagcgtc tcttttgtga tgagcatgtt
    20101 tttgaaaaat atattcaaat gtatggaata gcttgctttg atagtgctca atcatatcat
    20161 acttatcctt atagtgagta tagaagctgg aacgactaat tccggctttt tctactaatt
    20221 tgacagtaga aattttatca aatggctgtt ccatcagtaa ttgtaccata gcattttcaa
    20281 tagttcgctt tgtttttaag cgtttgttac tttcttgcat atttcctcct tgtaaacaaa
    20341 ttagactata tgtctaaaaa tagatttttt atcttgtaat ttagattttt taatgtataa
    20401 tctattatat caaaatttta gacaatatgt ttaaaaaagg agaaactaag tttaaagaat
    20461 ggaaagcaat ttaaaaaaaa ccaaccttta ttattgtcat gatcgggatt tctcttattc
    20521 cagatctgta caatatcata tttttgtcat caatgtggga tccatatggg caattgtctg
    20581 acttacctgt ggcagttgta aataatgata aagaggcttc ctataatggt aatactatgg
    20641 caatagaaaa agacatggtg tccaatttaa aagaaaataa aaccttggat tttcattttg
    20701 tagatgaaga ggaaggaaag aagggattgg aagatggcga ttactatatg gtagtgactt
    20761 taccaagtga tttatctgaa aaaacaacta cattatccaa tattcaatcg acagcagctt
    20821 atcaatcatt gacaagtgag caacaaactg agataagtga ttctgtatct caaaattcaa
    20881 ctgatagtat tcaatcggct cagtcaattg tagctttagt acaagattta cagggaagtt
    20941 tagaaaactt acaaaatcaa tcttctaatc tttcgacttt aaaaaatcaa tctaatcaag
    21001 tatcacctat tacttctact tctttgatag gattgtcaag tggattaaca gagatacaag
    21061 gagatgttac tagcaaatta gttcctgcca gtcagtcgat tgcatcaggt gtaaacgcat
    21121 atactacagg tgttgataaa gtttctcagg gcgcaagtca actaagtgaa aaaaatgcca
    21181 ccttgacagg tagtttggat aaactagttt caggctcaaa caccttgaca caaaaatctt
    21241 ctagattgac agcaggagtt ggttaattac aatcaggatc tgggcaatta gcagacaaat
    21301 ccagtcagtt actttcaggt gcttctccat tagagaatag agctaataaa ttggcagatg
    21361 gatctaggaa actagcagaa ggtggaacaa agttaacttc tggattggaa gatttacaga
    21421 caggacttgc ttctttagga caaggactag gtaatgctag tgatcaactc aaatcagtat
    21481 caacagaatc taaaaatgca gagattttgt caaatccact caatctttca aaaacagaca
    21541 atgatcaagt tcctgtaaat ggaatcgcaa tagctcctta tatgatatca gttgctcttt
    21601 tttttgcagc aatatcaaca aatatgatat ttgcgaaatt gccttcagga cgtcatccag
    21661 agagccgttg ggcttggttg aaatcttgag ctgaaataaa tggtattata gctgttttgg
    21721 caggaatttt ggtatatgga ggagttcagc ttattggttt aactgctaat catgagatga
    21781 gaatatttat tctcatcatc ctaacaagtt tagtattcat gtctatggtg accactttag
    21841 caacgtggaa tagccgtata ggagcttttt tctcacttat tttgctttta ctacagttag
    21901 catcaagtgc aggtacttat ccacttgctt tgacaaatga tttctttaga tctattaatc
    21961 cctggttacc aatgagctat tcagtttcgg gattacgaca aacaatctct atcaacaagt
    22021 cattttccta gctgtcatac tagctctatt tactggttta ggtatgctag cctatcaaca
    22081 taagaaaatg gaagaagatt aaaaaaatcg accgattaac tggtcgattt tttatgcctt
    22141 agatgacttt cgtctgtgat tatagattcc aaatagtaag agagaagtaa aggaacagat
    22201 tgctccagta ataaaaccat tgggaatgaa ggaaagtgta atagttcctt tccccttggg
    22261 aatgtcaact ttcataaatc cagtttgagc ttgtttaatt tctattttct taccatcttg
    22321 gtaggcagac caacctttgt cataaggaat ggtgaagaaa atagatgtat cttgttggac
    22381 atcatatgta gcaaaaacct tgtttttaga agttgatact gtgacaggtt gttctttaat
    22441 tttttgaatt gcctcggtga aagttttggt atctaaacga tagaaggtag gagattcaaa
    22501 tgatacttgt gaatttccag ggaaactaac attgatattg aaagtttttt tctctttagt
    22561 atatcctaga ttaaagaagg agaagacatt atcagttgta aaagtctttt tttcaccatt
    22621 tacaaggatg tcaaccttct tttgtttatc gttagaaaag tgaaggttta tgaaagagag
    22681 ataaacttgg ctgttttctg gaacttcaat ttgatactgg attgctgcat cttcatttga
    22741 agaacttgtg acactaatca aatcattagt attttctatt ttttctgttt tttcataagg
    22801 tattggagaa aaataatcaa aattgacgtt agcaagttga tttaaaaatg aggcctgatt
    22861 atccaaggta tgttcattta acttgacatc attgtaaaca gattgactag caactgcaat
    22921 cggaagagag tattgatttt catatagggt aagattatct ttttgataga tatctttaaa
    22981 gccatactta tcaataggac tgtctgagat attgtactgg ataccaaata aactatcagc
    23041 caaaatacta ttatttgcat atcggagatt gagattagtc ccagaggatt taaaaccaag
    23101 tttatctaaa gtagagcttg atgaacgatt tcgaacagat gaaaattgag agattccatt
    23161 gtagttgaat ttcatactgt catttcctgt ctgagtttgt agtttttcag tacgagtaaa
    23221 ttgatttcca atatatgttg agaaagattc catagctggg atatctcgac tataagcact
    23281 tcgagaagca aatccccatt ccttagcaat tccgtccatt tgagatgaag catttaaact
    23341 catttcaacc agtataaata aagagattag aatggcaaat agattcacag atataaactt
    23401 tttgataact gcaaggagta aaagagaata gacaaccaaa aattcaagag taagcagaat
    23461 attcaaatct gttaaaaaag aataatgcga ttttagatag atggtagcta aaaatcctgc
    23521 tactacaaga aaaagcgaaa ctaaaaaatt ccagacttta agttctttca gacgctttaa
    23581 gacttctgct gctgtgtaaa ttaacaaggt agagaaaatc caagcatagc gatgtaaaaa
    23641 catgtttgga gtatgcatgc cttgccaaaa taagtcaaga gcttctatgt aaaagcttgc
    23701 aattagaaat gcaaagaata ttacatatat gagtttcacg tgaaacttaa tagatttcag
    23761 cgtaaaaaat aaaatggtca aaataaaggg aaatagtcca acaaaaatca ttgggatggc
    23821 cccatacttt gttgtgtcaa aggaaccaat gaattgctta gcaaagagat caagatacca
    23881 gctactttca gtttgaaact ttgtaacttc agtcaatttt tccccatgtg tctgtaaatc
    23941 aaatagagtg ggaagagtca taatcaaact agccatacca gctaaaaagg agataactat
    24001 gaaatcaaga acagatgatt ttcgagtctt aaagtcccac gaaatttgac agagatacca
    24061 gaaaataaga aacaatactg tcatatatcc aaaataataa ttttgaataa ataagattga
    24121 cagacttgta aagtacaata ggagtttctt ttcagttatc agtagatgta aaccagttat
    24181 aattaaagga atcaagataa aaacatctag ccaggttttt atctctaatt gactgacagt
    24241 gaaactcatc agagcatagg aagtagataa ggctagtttt aaagtctgag ggatagattg
    24301 aaacaattta ttcaaactaa aaaaggttga cagaccaatc aatccaaatt ttaagagagt
    24361 ggtcagatag acagcatctg gcatattcgt tagatcaaaa aagtaaacta gaggcgcgag
    24421 aaaactaccc aagtaataac tagatagggc atagaagttt agccctagac cacttgtaaa
    24481 ggtgtaaaac agactactat ttccatgtag gatatttcgt aaggctacat caaaaataac
    24541 gtattgatga aagccatctc ctaatagagg agagttgtcg ctattccagt agataccttg
    24601 agatagatat actccagaca taatcactac aggaatgatg aaagaaataa aataggttcg
    24661 atatgttttt aaaaatgatt tcatgttacc tcgtagaatg atagaaaact cagttggtta
    24721 acccaactga gttttgaagt tttatttagt ctttccaaag ttctttaact tttgcttgta
    24781 cttctgcatt ttctaggaat tcatcgtagg tttcatcgat acggtcaatg acgccatttt
    24841 tagataagac aatgatatgg ttagccaaag tttgaataaa ttcgtggtca tggctagcaa
    24901 agatgattga ttctttaaag tttttcaatc catcattcaa gcttgagata gattccaagt
    24961 ccaagtgatt tgttggatca tcaagtacaa ggacatttga ttttaagagc atgagttttg
    25021 aaagcatgac acgaactttt tctccccctg acaagacatt tacaggtttg ttaacttcat
    25081 ctccagagaa gagcatacgg ccgaggaagc cacgtaggaa agtattgtca tcttcttctt
    25141 tacttgcgaa ttgacgcaac cagtcaagaa ttgattctcc tcctgcaaaa tcagctgagt
    25201 tatcttttgg taggtaagat tgactagttg taactcccca cttgacagtt ccttcatagt
    25261 caatatctcc catgattgca cgaattaatg cagtcgtttg aatatcattt tgtccaataa
    25321 gtgctgtctt atcatctgga cgcaagatga aactaatatt atccaagata gtttcaccat
    25381 caatctttac agttagattt tctactgtca agagatcatt accaatctca cgttccgctt
    25441 taaagttgat aaatggatat ttacgactag atggcacaat ctcttctagc tcaatcttat
    25501 caagcatttt cttacgtgat gttgcctgcc ttgacttaga agcattggca gagaaacgag
    25561 caacaaattc ttgcaattgt ttaatttttt cttctgcttt agcattacgg tctgctagca
    25621 atttagcagc aagctcagaa gattccttcc agaagtcgta gtttccgaca tagagtttga
    25681 tttttccaaa gtcaaggtcg gccatgtgag tacaaacttt gtttaagaag tgacggtcgt
    25741 gggatactac gataactgtg ttatcaaagt caatcaagaa gtcttctaac caagtaatcg
    25801 attggatatc caaaccgtta gtaggctcgt ccaagagaag aacatctggt ttaccaaaaa
    25861 gtgctttggc gaggagaacc tttacttttt caccgttggc caattcgctc atgttttggt
    25921 agtgtaattc ttctggaatg tttaggtttt gaagtagttg agaggcttca ctctctgctt
    25981 cccaacctcc aagttcggca aattctcctt cgagttcggc agcacgaacc ccgtcctcgt
    26041 ctgagaaatc ttccttcatg tagatagcat ctttctcttt catgatgcta taaagttttt
    26101 catttcccat gataacgaca tcaatggcac gttcatcttc gtagtcaaag tgattttgac
    26161 gaagaacaga gagacgttca tctggaccaa gagagatgtg accagtagta ggttcgatat
    26221 ctccagctaa aatttttaaa aaggttgatt ttccggcacc attagcaccg attaatccgt
    26281 aagtatttcc ttctgtaaat ttgatattga catcatcaaa aagtttgcga tcactaaaac
    26341 gtagtgaaac atcagatact gtaagcaata tttttctcct atatgtgtaa tatatttatt
    26401 ctactagaaa atacagaaat attcaaattt ttatttgtca attttgtgta aaatatattt
    26461 acagtatcct ttacacaaat ctgtaaaaag caaggctgat ttattttgat aaattacggt
    26521 tatttcatta aaaaaatgct ataattgaaa ggactatatc gaaggagaac aaaatgacta
    26581 aacccattat tttaacagga gaccgtccaa caggaaaatt gcatattgga cattatgttg
    26641 gaagtctcaa aaatcgagta ttattacagg aagaggataa gtatgatatg tttgtgttct
    26701 tggctgacca acaagccttg acagatcatg ccaaagatcc tcaaaccatt gtagagtcta
    26761 tcggaaatgt ggctttggat tatcttgcag ttggattgga tccaaataag tcaactattt
    26821 ttattcaaag ccagattcca gagttggctg agttgtctat gtattatatg aatctagttt
    26881 cgttagcacg tttggagcga aatccaacag tcaagacaga gatttctcag aaaggatttg
    26941 gagaaagcat tccgacagga ttcttggtct atccaatcgc tcaagcagct gatatcacag
    27001 ctttcaaggc taattatgtt cctgttggga cagatcagaa accaatgatt gagcaaactc
    27061 gtgaaattgt tcgttctttt aacaatgcat ataactgtga tgtcttggta gagccggaag
    27121 gtatttatcc agaaaatgag agagcagggc gtttgcctgg tttagatgga aatgctaaaa
    27181 tgtctaaatc actaaataat ggtatttatt tagctgatga tgcggatact ttgcgtaaaa
    27241 aagtaatgag tatgtataca gatccagatc atatccgcgt tgaggatcca ggtaagattg
    27301 agggaaatat ggttttccat tatctagatg tttttggtcg tccagaagat gctcaagaaa
    27361 ttgctgatat gaaagaacgt tatcaacgag gtggtcttgg tgatgtgaag accaagcgtt
    27421 atctacttga aatattagaa cgtgaactgg gtcctattcg tgagcgccgt attgaatttg
    27481 ctaaggatat gggagaagtt tataatatga ttcaaaaagg tagtgaaaga gcgcgtgaag
    27541 ttgcgggtca aaccctatct gaggtaaaag gggcaatggg acttcattac tttaactaag
    27601 tttattttac aagaaactat catttctatc tcgaagaaaa gatagttttt tatttacccc
    27661 tgtaacattt gacaaatttt tatagaatgg tatgatagat acaatataaa aagagtcaag
    27721 ctcaaaaaga aagaaaagag gaaacttcga atgtctaatt gggacactaa atttttgaaa
    27781 aaaggtttta cctttgatga tgtattgctt attccagctg aaagtcatgt gttgcctaac
    27841 gatgcagatt taacaactaa attggcagat aatttgactt taaatatccc aattattacc
    27901 gctgccatgg acacagttac agagagtcaa atggccattg ctattgctcg tgcaggtggt
    27961 ctcggagtta tccataaaaa catgtcaatt gctcaacaag cagacgaggt tcgtaaggta
    28021 aaacgttctg aaaatggagt tattattgat ccgttcttct tgacgcctga acatacaatt
    28081 gctgaagcag atgagcttat gggtcgttac cgcatcagtg gtgttccagt tgttgaaaca
    28141 cttgaaaatc gtaaattggt tggtattttg acaaaccgag atcttcgttt tatttcagat
    28201 tataatcaac caatttcaaa ccatatgact agtgaaaatc ttgttactgc tcctgtgggt
    28261 acggatcttg caacggctga gagtattctt caagagcatc gtattgaaaa acttccgttg
    28321 gtcgatgaag aaggcagttt ttctggtttg atcactatca aagatattga aaaagttatt
    28381 gagtttccaa atgcggctaa agatgaattt ggtcgtcttc tagttgcagg tgcagtaggt
    28441 gttacttcag atacatttga acgtgcagag gctctttttg aggcaggagc ggatgcgatt
    28501 gttattgata ctgcacatgg tcattctgca ggtgtcttgc gtaaaattgc cgagattcgt
    28561 gctcatttcc cagatcggac tttgattgct ggaaatattg ctactgctga aggtgcacgt
    28621 gccctttatg aagcgggtgt agacgttgtt aaggttggta ttggaccagg ttctatctgt
    28681 actactcgtg tgattgctgg tgttggtgtt ccgcaagtaa cagctatcta cgatgctgca
    28741 gctgttgcgc gcgaatatgg taaaacgatt attgctgacg gtgggatcaa gtattctgga
    28801 gatattgtaa aagcacttgc tgcaggtgga aatgctgtta tgcttggatc tatgtttgct
    28861 ggaactgatg aagctccagg cgaaactgaa atcttccaag gacgtaaatt caagacttac
    28921 cgtggtatgg gatcaattgc tgctatgaag aaaggttcaa gcgaccgtta tttccaaggt
    28981 tctgtcaatg aagcaaacaa gctcgttcca gaaggaattg aaggtcgtgt tgcttataaa
    29041 ggagcggcag ctgatattgt tttccaaatg attggtggta ttcgctctgg tatgggttac
    29101 tgtggtgcag ctaaccttaa agaactacac gataatgctc aatttattga aatgtctggt
    29161 gctggtttga aagaaagcca tcctcatgat gtgcaaatta ctaatgaggc accaaattat
    29221 tctatgtaaa aaacaatgaa aagaactcca gtgaaaacag gagttctttt acaatgttgt
    29281 caatttccat ttacagaagc tttaccatcc tgaatagtga agatacttag attttctggc
    29341 agattttgaa gatggtctaa gcttgttgtt gtgataaagg tttggattga ttgagaaatc
    29401 gtttctaata attttaactg tctagtgttg tcaagttcac tcatcacatc gtcaagcagt
    29461 aatatcggag attctgtggt aatgctttcc attaattcga tttctgctaa ttttatcgag
    29521 aggacgagac tacgatgttg accttggctt ccgaaactag catccatccc atttatataa
    29581 aaagaaatgt catctcgatg aggaccgaca ccagtattct ttttaaataa atctctggat
    29641 ctactttttt ctaaagcaat tttgaaagat tcggataagt tttgtttgtc agttatattg
    29701 acagaagatt gataggatat tgacaactct tcgatctgat tagagagttc aaaatgtttc
    29761 ttacgcccaa atgattctag tttttttatg aaatctaagc ggtgattcat tacacgacat
    29821 ccataatcaa ctagctgatc atctaacaca gaaaggaatg tttcatctat tttttgatct
    29881 gattttaggt aagtgtttct ttgctttagg atgtggttat aattggttaa gtcagataag
    29941 tagattggct taatttgccc aagttccata tcaatgaatt ttcgtcgaat cgaaggtgct
    30001 cctttaatta gttgtaaatc ttcaggagca aataagacaa cattcatgtg tcctacataa
    30061 tctgaaaggc gtgcctgttt taagtgatta acttttgtta cacggccttt ttgtgttagt
    30121 tcgatttcta ggggaatgga tccagttttt ttctgaacga gacctgaaag atgaagttgt
    30181 tcctcatcaa aatgaatgag atttttatct gttcgagttc gatgactacg cgttaaggct
    30241 aaaaaataga tagcctctaa catgtttgtt tttccttgtg cattacgtcc caaaaagaca
    30301 ttcaatttag gattaaagtc tattttcgtt tctttgtaat tacgaaaagt cttgagagat
    30361 agatgttgta gccacatgat tatctaccag ggaatcgtgg agcttgttgg cttttaggtg
    30421 atgaagcagg tttcgatttg tcttttttaa ctcccttatt catctttttg acaagtttag
    30481 cgatccgttc tttttcaact ttatcagctt ggtattcatc ttgttcttca gaagtaggtt
    30541 gtgtcaacaa gatgtcaatg ttcatgtcag ggatgtcaac tttatcgcca atacgaagtt
    30601 tttttccacg acgactctct aattccctat taaagtaaac agaatgttca gagagaaatg
    30661 atttaatagc tcctccgcta tgtgtaattc caagttcttt gagtagtgct tggagggtaa
    30721 taaattcttc aaataatttg tattccataa ttcacctcaa tctttggtat tataccatat
    30781 tttcctaaaa atagtgagag agacagcgag aaatgtaagc gatttttatt tcaaaagtgt
    30841 tacagggaac aagaaaattt caggttttcg tgatataata gaagtctgta tataaggagg
    30901 taaatcatgg agttagtgca tggaatttca acacatttta tccaatcaaa aaagtttaaa
    30961 acaaacaaaa ttaccgtgcg ttttaccgct ccattatccc ttgatacgat tgcaggtcac
    31021 atgttgagtg caagtatgct agagactgct aatcagatgt accctacttc tcaagatttg
    31081 aggagacact tggccagtct atacggtaca gatatgtcaa ccaattgttt cagaagaggg
    31141 caaagccaca ttatagaatt gacatttacc tatgttcgtg atgagttttt aagtaggaaa
    31201 aacgtgctaa cctctcagat tttggaactt gtaaaagaaa ctcttttttc acccgtagta
    31261 gttgataatg ggtttgatcc ggccttattt gaaattgaga aaaaacaatt gctagcaagt
    31321 ttagcagctg atatggatga ttctttttat tttgcacata aagaattgga taaattgttt
    31381 tttcatgatg aacgtcttca attggaatat agtgatttac gaaatcgtat tttagatgaa
    31441 actccacaaa gttcttattc ttgtttccaa gaatttttag ccaatgatcg aatagatttc
    31501 tttttcctag gtgattttaa tgaggttgaa attcaaaatg tattagaatc atttggcttt
    31561 aaaggtcgaa aaggagatgt gaaggttcag tattgtcaac cttattctaa tatccttcag
    31621 gaaggtatgg ttcggaaaaa tgtgggacaa tccattttgg aattaggtta tcattaccgt
    31681 tctaaatatg gtgatgaaca acatttaccc atgattgtaa tgaatggttt acttggtgga
    31741 tttgctcact ctaagctctt tacaaatgtc cgtgaaaatg ctggattagc ttataccatt
    31801 tcaagtgagc ttgatttatt tagtggattc ttgaggatgt atgctggtat caatcgagaa
    31861 aatcgtaacc aggctcgtaa aatgatgaat aatcaactgc ttgatttaaa aaaaggttat
    31921 tttacagagt ttgagttaaa tcagaccaag gaaatgattc gttggtcgtt gttactttct
    31981 caagataatc aatcttcatt gattgaacgt gcttatcaaa atgccttatt tggaaaatct
    32041 tcagcagact ttaaaagttg gattgcaaag cttgaacaaa ttgacaaaga tgctatttgt
    32101 agagtagcta ataatgtgaa actacaagcg atttacttta tggaaggaat agaatgacaa
    32161 aggttgtttt tgaagaaaaa tactatccag ctgtaaaaga aatggtttat cgaactcgtt
    32221 tggccaacgg attgacagtt gctcttttgc ctaaaaagga atttaaagag gtttacggga
    32281 gtgtcactgt acagtttggt tcggtagata cgtttgtcac agaagttgac ggagatgtaa
    32341 aacaatatcc tggaggaatt gctcattttc ttgaacataa attatttgag agagaagatt
    32401 ctagtgattt gatgtcggct tttacgaatc taggtgcaga tagcaatgcc tttacaagct
    32461 ttacaaaaac aaactatctt ttttcagcaa cggattattt tttagaaaat ttagatttac
    32521 ttgatgaatt ggtaacatca gcacacttta ctgaagcttc cattctgaca gagcaggata
    32581 ttattcagca agaacgagaa atgtaccaag atgatccaga ttcgtgttta ttcttttcaa
    32641 ctttagcgaa tttgtatcct ggtacacctt tagcaactga tatagttgga agtgaggagt
    32701 ccatttccca aatcaatcta actaatttgc aagaaaattt tacaaagttt tacaaacctg
    32761 taaacatgtc tctgttttta gttggtaatt ttgatgtgga gcgagtacag gactattttg
    32821 aaagcaaaga actgaaagat tcagattttc aggaagtagc aagagaaaag ttgtttttac
    32881 agcctgtaaa gctaacagat agtatgagaa tggaagtatc ttctcccaaa ctagcgattg
    32941 gagttagagg taagcgagaa gtttctgaag cggattgcta tcgacatcat attttattaa
    33001 aattattgtt tgcaatgatg tttggttgga cttcggatcg ttttcaaaaa tgttatgaat
    33061 caggtaaaat tgatgcgtcc ttatctctgg aagttgaaat aacaagtcgc tttcattttg
    33121 tcatgttgac aatggatacg aaagagccag ttgctttgtc tcatcaattt aggaaggcta
    33181 ttcgtaattt tacaaaggat ttagatatta cagaggaaca tttagatatt atcaaaagag
    33241 agatgtttgg cgaatttttc agtagcatga actctcttga atttattgca acgcaatatg
    33301 atgcttttga aaatggtgag acaatttttg atttgccgaa aattttacag gaaattactt
    33361 tagaggatgt ccttgatgct ggacatcatt taatagatga tggtgacata gttgatttta
    33421 caatattccc atcgtagtaa cctatcataa tagacactag aaagaagaga tgacaagtat
    33481 gagaaaaaaa acaattggag aggttttacg attagctaga atcaatcagg gattgagttt
    33541 agatgaattg cagaaaaaga cagaaatcca gttagatatg ttggaagcaa tggaagcaga
    33601 cgatttcgat caacttccaa gtccttttta cacgcgttct ttcttgaaaa aatatgcatg
    33661 ggctgttgag ttagatgacc aaattgtttt ggatgcttat gattctggga gtatgattac
    33721 ttatgaggaa gtagatgttg atgaagatga gttgacaggt cgtagacgtt caagtaagaa
    33781 aaagaagaaa aaaacatcat ttttaccttt attttatttt atcctttttg ctttatcgat
    33841 tttaattttt gtgacttatt atgtttggaa ctatattcaa actcaaccag aggagccttc
    33901 tctttctaat tacagtgtgg ttcaatcaac aagttcaact agctctgttc cccactcctc
    33961 aagtagtagt tcttctagta tagaatcagc tataagtgta tcaggcgaag gaaatcatgt
    34021 agaaatcgct tataagacaa gtaaggaaac agttaaattg caattggcag tttcagatgt
    34081 tacaagttgg gtcagtgttt cagaaagcga acttgagggc ggtgtaacct tatcgccaaa
    34141 gaagaaaagt gcagaagcaa cagttgcaac taaaagtcct gtaacaatta cgttaggtgt
    34201 tgtaaaaggt gttgatttga cagtagataa tcagactgtt gatttatcga aattaacagc
    34261 tcagactgga caaatcactg taacctttac taaaaattaa ggaaaaacga atgaaaaaag
    34321 aacaaattcc caatctctta acaataggtc gaattctctt tatacctatt tttatcttta
    34381 ttttaacgat aggaaattcg atagagagtc atatagttgc agctattatc tttgctgttg
    34441 ccagtattac cgactattta gatggatatt tagctcgtaa atggaatgtg gtcagtaatt
    34501 ttggtaaatt tgcagatcct atggcggata agttactagt tatgtcggct tttattatgt
    34561 tgattgagtt aggtatggct ccggcttgga ttgttgcagt gattatctgt cgtgagttag
    34621 ctgtgacagg tttaaggctt ttattggttg aaactggtgg aacaatttta gcagcagcaa
    34681 tacctggaaa aattaaaact tttagtcaga tgtttgctat tattttcttg ctattacatt
    34741 ggactttgct tggtcaagtt ctactttatg tagccttatt tttcactatc tactctggct
    34801 atgactattt caagggtagt gcctatgtat ttaaagggac atttggttcg aaatgaaatc
    34861 aataattgat gtaaaaaatc tttcttttcg ctataaagaa aatcagaact actacgatgt
    34921 gaaggatatt acgtttcacg tgaaacgtgg agaatggctt tcgattgtag ggcataatgg
    34981 tagtggtaaa tcaacgacgg ttcgattaat tgatggctta ctggaagcag aatccggaga
    35041 gattgtaatt gatggccaac gtttgactga ggaaaatgtt tggaatatac gtcgtcaaat
    35101 cggtatggtt tttcaaaatc cagacaatca atttgttgga gcgactgttg aagatgatgt
    35161 tgcttttggt ttggaaaatc agggactttc tcgtcaagaa atgaaaaaga gagtggaaga
    35221 agctctggct ttagttggca tgttggactt taaaaagaga gagccagcgc gtctatcagg
    35281 tggccaaaag caacgtgtgg ccattgcagg tgttgtagcc ctaagaccag ctattttaat
    35341 cttagatgaa gcaacgagta tgttggatcc tgaggggcgt agagaactta ttgggacagt
    35401 aaaaggaatt cgaaaagact atgatatgac ggtcatttct attacccatg atttggaaga
    35461 agtcgccatg agtgatcgcg tattggtcat gaaaaaaggg gaaattgaat caactagtag
    35521 tccaagggag cttttctctc gaaatgattt agatcaaatt ggattagacg atccttttgc
    35581 taatcaatta aaaaaatctt tgagccagaa tggctatgat ttacctgaaa attatttgac
    35641 agaaagtgag ctagaggata agctatggga attgctctag aaaatgtgaa ttttacatat
    35701 caagaaggta ctcccttagc ttcagcagct ttgtcggatg tttctttgac gattgaagat
    35761 ggctcttata cagctttaat tgggcacaca ggtagtggta aatcaactat tttacaactc
    35821 ttaaatggtt tattggtgcc aagtcaaggg agtgtgaggg tttttgatac cttaatcacc
    35881 tcgacttcta aaaataaaga tattcgtcaa attagaaaac aggttggctt ggtatttcag
    35941 tttgctgaaa atcagatttt tgaagaaacg gttttgaagg acgttgcttt tggaccgcaa
    36001 aattttggag tttctgaaga agatgctgtg aagactgcgc gtgagaaact ggctctggtt
    36061 ggaattgatg aatcactttt tgatcgtagt ccgtttgagc tgtcaggggg acaaatgaga
    36121 cgtgttgcca ttgcaggcat acttgccatg gagccagcta tattagtctt agatgagcca
    36181 acagctggtc tagatcctct agggagaaaa gagttgatga ccctgttcaa aaaactccac
    36241 cagtcaggga tgaccatcgt cttggtaacg catttgatgg atgatgttgc tgaatatgcg
    36301 aatcaagtct atgtaatgga aaagggacgt ttagtaaagg ggggcaaacc aagtgatgtc
    36361 tttcaagacg ttgtttttat ggaagaagtt cagttgggag tacctaaaat tacggccttt
    36421 tgtaaacgat tggctgatag aggcgtgtca tttaaacgat taccgattaa gatagaggag
    36481 ttcaaggagt cgctaaatgg atagtatgat tttggggcgt tatatcccag gggattcgat
    36541 tgttcaccga ttggatccac gtagcaaatt gcttgctatg atgctactga ttttgattgt
    36601 gttttgggct aataacccct tgacgaatct gattcttttt atagcgacag ggatatttat
    36661 tgccttgtca ggagtatctc tttcattttt tattcagggc ttgaagtcta tgtttttctt
    36721 gattgccttc acaactattt ttcaactatt tttcatttct aatgggaatg ttttatttga
    36781 gttttcgttt gtgagaatca cggattatgc tttgcaacaa gctgggatta ttttttgtcg
    36841 ctttgtattg attattttct tttcaacttt gttaacctta acaaccatgc ctttaagttt
    36901 ggcatcagct gtcgaagctt tattagcacc tttaaagcgt gtgaaagttc cagttcatga
    36961 aattggattg atgctgtcta tgagtttgcg ttttgtccca accttgatgg atgatacgac
    37021 tcggattatg aatgcacaga aagctcgtgg agtggatttt ggagaaggaa gcatcgttca
    37081 aaaagtaaag gcgatgattc ccattttgat tcctcttttt gcgacaagtt taaaacgtgc
    37141 agattccttg gctatcgcta tggaagcgcg tggctatcag ggtggaaaag gcagaattca
    37201 ataccgacaa ttgaaatgga ctctaaagga tacgctgacc attcttgtta ttctcgtact
    37261 tggttgttgt ttatttttct taaaatctta gtagctttca ggaattgata aaaagttact
    37321 gtaacagttt ttgatagaaa ggtagggata tgaaccgttt taaaaaatca aaatatgtca
    37381 ttattgtttt tgtcactgtt ctgcttgtgt cagctctctt agcgacgact tattcaagta
    37441 caattgtgac aaaattagga gatggaatct cattggttga tagagttgta caaaaacctt
    37501 ttcagtggtt tgattctgtc aaatcagatt tggctcattt gacacgaaca tataatgaaa
    37561 atgaaagttt gaagaaacag ctttaccaat tagaagttaa atcaaatgag gtggaaagtt
    37621 taaagacaga aaatgaacaa ctgcgccaat tgcttgatat gaagtctaaa ttgcaagcca
    37681 caaagacttt agcagcagat gttattatgc gttctccggt atcttggaag caggagttga
    37741 ccttagatgc aggtagatca aaaggtgctt ctgagaacat gttagctatt gcaaatggtg
    37801 gcttgattgg gagtgtttca aaagtagagg agaactctac tatagtcaac cttctgacaa
    37861 atacggaaaa tgctgataag atttctgtta aaattcaaca tggctctact acaatttatg
    37921 gaattattat tggctatgac aaggaaaatg acgttcttaa aattagccaa ttaaatagta
    37981 atagcgatat tagtgcggga gataaggtga ctactggtgg attaggaaac tttaacgttg
    38041 ctgatattcc tgttggtgaa gtggttgcca caacgcatag tacagactat ttgacacgag
    38101 aagtaactgt taaattgagt gcagatactc ataatgtaga tgtgatagaa ttagtgggga
    38161 attcataatg agacagttga agcgagttgg agtattttta ttgcttcctt tctttgttct
    38221 aattgacgcc catattagcc agcttctggg ctcatttttc ccccatgtac atttggctag
    38281 tcattttctt tttctatttc tcttatttga gacgatagaa gtatcagagt atctctacct
    38341 agtctattgt tttgttatag gcttggttta tgatgtttac tttttccatc taatagggat
    38401 tacaactctc ttatttatct tattgggagc cttccttcat aaattgaata gtgttatttt
    38461 gttgaatcgt tggacaagaa tgctagctat gattgtgctg acattcctgt ttgaaatggg
    38521 tagttatctt ttggctttta tggtagggtt gacagtagat agcatgtcga tttttatagt
    38581 ctatagcttg gtaccgacga tgattttaaa ttttttatgg attactgttt ttcaatttat
    38641 ttttgaaaaa tattatctat aagaacgaca tataaatgta acaaaggcgt aatatttatt
    38701 aggccttttt ttggtatact agtattgtct ttaaaagaag gagtatctac gtaatatgaa
    38761 gaaaaaaatc ttagcgtcac ttttattaag tacagtaatg gtttctcaag tagctgtttt
    38821 aacaactgcg catgcagaaa cgactgatga caaaattgct gctcaagata ataaaattag
    38881 taacttaaca gcacaacaac aagaagccca aaaacaagtt gaccaaattc aggagcaagt
    38941 atcagctatt caagctgagc agtctaactt gcaagctgaa aatgatagat tacaagcaga
    39001 atctaagaaa ctcgagggtg agattacaga actttctaaa aacattgttt ctcgtaacca
    39061 atcgttggaa aaacaagctc gtagtgctca aacaaatgga gccgtaacta gctatatcaa
    39121 taccattgta aactcaaaat caattacaga agctatttca cgtgttgctg caatgagtga
    39181 aatcgtatct gcaaacaaca aaatgttaga acaacaaaag gcagataaaa aagctatttc
    39241 tgaaaaacaa gtagcaaata atgatgctat caatactgta attgctaatc aacaaaaatt
    39301 ggctgatgat gctcaagcgt tgactacgaa acaggcagaa ctaaaagctg ctgaattaag
    39361 tcttgctgct gagaaagcga cagctgaagg ggaaaaagca agtctattag agcaaaaagc
    39421 agcagctgag gcagaggctc gtgcagctgc ggtagcagaa gcagcttata aagaaaaacg
    39481 agctagccaa caacaatcag tacttgcttc agcaaacact aacttaacag ctcaagtgca
    39541 agcagtatct gaatctgcag cagcacctgt ccgtgcaaaa gttcgtccaa catacagtac
    39601 aaacgcttca agttatccaa ttggagaatg tacatgggga gtaaaaacat tggcaccttg
    39661 ggctggagac tactggggta atggagcaca gtgggctaca agtgcagcag cagcaggttt
    39721 ccgtacaggt tcaacacctc aagttggagc aattgcatgt tggaatgatg gtggatatgg
    39781 tcacgtagcg gttgttacag ctgttgaatc aacaacacgt atccaagtat cagaatcaaa
    39841 ttatgcaggt aatcgtacaa ttggaaatca ccgtggatgg ttcaatccaa caacaacttc
    39901 tgaaggtttt gttacatata tttatgcaga ttaatttaca gagggactcg aatagagccc
    39961 tcttttcagg ttttaccgtg acaatcccta ttaaaaatta tatcaaaata gcttgaaaat
    40021 attggaaaag tatggtaaaa tgaaaattgt cgtgtgaacg ataatactca ttcttgatga
    40081 attgtgaagc agttgccctt gggtcgtttt gcgagttgaa gtcaagaaga ggaaaaaaac
    40141 aaaaaggaga aatactcatg gcagtaattt caatgaaaca acttcttgag gctggtgtac
    40201 actttggtca ccaaactcgt cgctggaatc ctaagatggc taagtacatc tttactgaac
    40261 gtaacggaat ccacgttatc gacttgcaac aaactgtaaa atacgctgac caagcatacg
    40321 acttcatgcg tgatgcagca gctaacgatg cagttgtatt gttcgttggt actaagaaac
    40381 aagcagctga tgcagttgct gaagaagcag tacgttcagg tcaatacttc atcaaccacc
    40441 gttggttggg tggaactctt acaaactggg gaacaatcca aaaacgtatc gctcgtttga
    40501 aagaaattaa acgtatggaa gaagatggaa ctttcgaagt tcttcctaag aaagaagttg
    40561 cacttcttaa caaacaacgt gcgcgtcttg aaaaattctt gggtggtatc gaagatatgc
    40621 ctcgtatccc agatgtgatg tacgtagttg acccacataa agagcaaatc gctgttaaag
    40681 aagctaaaaa attgggaatc ccagttgtag cgatggttga caccaatact gatccagatg
    40741 atatcgatgt aatcatccca gctaacgatg acgctatccg tgctgttaaa ttgatcacag
    40801 ctaaattggc tgacgctatt atcgaaggac gtcaaggtga ggatgcagta gcagttgaag
    40861 cagaatttgc agcttcagaa actcaagcag attcaattga agaaatcgtt gaagttgtag
    40921 aaggcgacaa cgcttaattt atacaaatag taattaccta ggagggcggg gcttagcccg
    40981 gctctcctat tttcaaaaaa tgtaggagaa ttaaaatggc agaaattaca gctaaacttg
    41041 taaaagagtt gcgtgaaaaa tctggtgccg gtgttatgga cgctaaaaaa gcgcttgtag
    41101 aaacagacgg tgacatcgaa aaagcgattg aattgcttcg tgaaaaaggt atggctaagg
    41161 cagctaagaa agctgaccgt gttgctgcag aaggtttgac tggtgtttat gttaacggta
    41221 atgttgcagc agttattgaa gtaaacgctg aaactgactt cgttgcaaaa aacgctcaat
    41281 tcgttgaatt ggtaaatact acagcgaaag tcattgctga aggaaaacct gctaacaacg
    41341 aagaagctct tgctttgata atgccttcag gtgaaactct tgaagctgca tacgtatctg
    41401 caacagcaac tatcggagag aaaatctcat tccgtcgctt tgcattgatt gaaaaaacag
    41461 acgcacaaca ctttggagca taccaacata acggtggacg tatcggtgtt atttcagttg
    41521 ttgaagatgg agacgaagca cttgctaaac aattgtcaat gcacatcgca gcgatgaaac
    41581 caacagttct ttcttacaaa gaattggatg agcaattcgt taaagatgag ttggcacaat
    41641 tgaatcacgt tatcgaccaa gacaacgaaa gccgtgcaat ggttaataaa ccagctcttc
    41701 cacacttgaa gtatggatca aaagctcaat taactgatga tgttattgct caagctgaag
    41761 ctgacatcaa agctgaattg gctgcagaag gcaaaccaga aaaaatctgg gacaaaatta
    41821 ttccaggtaa aatggatcgc ttcatgcttg ataacactaa agttgaccaa gcttacacac
    41881 ttcttgcaca agtttatatc atggatgaca gcaagacagt tgaagcatac cttgaatcag
    41941 ttaacgcttc ggtagttgag tttgctcgct ttgaagttgg tgaaggtatc gagaaagctg
    42001 caaacgactt cgaagctgaa gttgcagcta caatggcagc agccttgaat aactaataat
    42061 agaaaggaag caaattgctt ccttttttgt atagggctta gatttttcct gaaattgttt
    42121 tttccccagt ctcactcgat tagaataatt aaaacaaaaa gccctataat aagggctaag
    42181 tgcatttagg agactatact tcaaattcat agtaagcgcg tcataacaag gtatctatcc
    42241 taattcccca acttccagta tactagataa aaaataatta tcggaggaaa ggtattgtac
    42301 tatgataatt caactaagtg atttaggtca agttcacctt gtttgtggca agacagatat
    42361 gaggcaggga atagactcat tagcctatgt agttaaaa
//
LOCUS       DAVHSO010000010        42278 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.010, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000010 DAVHSO010000000
VERSION     DAVHSO010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 42278)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42278)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42278
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.010"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..84
                     /locus_tag="VVR18_000523"
     CDS             <1..84
                     /locus_tag="VVR18_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HEU6032103.1"
                     /translation="PILFRIPAMSAPVFDNIEAAIKEHGLS"
     gene            132..1607
                     /locus_tag="VVR18_000524"
     CDS             132..1607
                     /locus_tag="VVR18_000524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HEU6032104.1"
                     /translation="MDAIFDLIGKVFNPILEMGGPVIMLIILTVLALLFGVKFSKALE
                     GGIKLAIALTGIGAIIGMLNGAFSASLAKFVENTGIQLSITDVGWAPLATITWGSAWT
                     LYFLLIMLIVNVVMLAMKKTDTLDVDIFDIWHLSITGLLIKWYADNNGVSQGVSLFIA
                     TAAIVLVGVLKIINSDLMKPTFDDLLNAPSSSPMTSTHMNYMMNPVIMVLDKIFEKFF
                     PGLDKYDFDAAKLNKKIGFWGSKFFIGFILGIVIGIMGTPHPIAGVADADKWRLVIKG
                     WLSLGLTAGVSLELFSLIGSWFIAAVEPLSQGITNVATKRLQGRKFNIGLDWPFIAGR
                     AEIWACANVLAPIMLIEAVLLSKVGNGILPLAGIIAMGVTPALLVVTRGKLLRMIIFG
                     TLLLPLFLLSGTLIAPFATELAKGVGAFPEGVSQTQLITHSTLEGPIEKLLGWTIGNT
                     TTGDIKAILGAVAFLVFYIGIFAWYRKQMIKRNEEYAAKAK"
     gene            1630..1707
                     /locus_tag="VVR18_000525"
                     /pseudo
     CDS             1630..1707
                     /locus_tag="VVR18_000525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            1867..8553
                     /locus_tag="VVR18_000526"
     CDS             1867..8553
                     /locus_tag="VVR18_000526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ig-like domain-containing protein"
                     /protein_id="HEU6032105.1"
                     /translation="MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVY
                     ADETLITHTAEKPKEEKMIVEEKADKALETKNVVERTEQSEPSSTEAIASEKKEDEAV
                     TPKEEKVSAKPEEKAPRIESQASNQEKPLKEDAKAVTNEEVNQMIEDRKVDFNQNWYF
                     KLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKIF
                     KLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLHKDGRENVI
                     AVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVT
                     SKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLW
                     TVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLH
                     HDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPSSEQTLQIAAELGLLVQEEAFD
                     TWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIG
                     EANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNY
                     SEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDR
                     VGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAG
                     IPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVE
                     LFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEI
                     ARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHG
                     QGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQVGKFTLTAHSDLLK
                     SNQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPTTVPFVYSDGSRAERPVTWSS
                     VDVSKPGIVTVKGMADGREVEARVEVIALKSELPVVKRIAPNTDLNSVDKSVSYVLTD
                     GSVQEYEVDSWEIAEEDKVKLAIPGSRIQATGYLEGQPIHATLVVEEGNPAAPVVPTV
                     TVGGEAVTGLTSRQPMQYRTLSYGAQLPEVTASAENADVTVLQASAANGMRASIFIQP
                     KDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPAD
                     KVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKGQVELTIQANTEKKIAQSIRP
                     VNVVTDLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQTFEVLGKVEGIDL
                     EARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYA
                     KEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVS
                     NVNDKLISYNNQPANRWTNWNRSNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVG
                     APKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHF
                     SFDKVETYAVRIRMVKADNKRGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPD
                     LTDYYLESVDGKVTAVTASVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFT
                     KDKNLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLTVEWEEVPAEN
                     LTKAGQFTIRGRVLGSDLVAEVTVRVTDKLGEALSDNPNYDENSNQAFASATNDIDKN
                     SHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVAQAKLHFFA
                     DSGTDAPTKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYRADKDIAAG
                     DEINVTFKAVKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELA
                     DFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSLPVLVRLVSESGKQVKEYR
                     IQLTKEKPVSAVQEDLPKLEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKTGKERIFT
                     AINPDGSKEEKLREVVEAPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSEASQTN
                     KAQLPNTGSAASQAAVAAGLALLGLSAGLVVTKGKKED"
     gene            complement(8801..9657)
                     /locus_tag="VVR18_000527"
                     /pseudo
     CDS             complement(8801..9657)
                     /locus_tag="VVR18_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014125496.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(9867..10226)
                     /locus_tag="VVR18_000528"
     CDS             complement(9867..10226)
                     /locus_tag="VVR18_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3397 domain-containing protein"
                     /protein_id="HEU6032106.1"
                     /translation="MGMILMKLASILLLILTLVICIILTKLFRLKKLGRNFADLAFPV
                     LVFEYYLITAKTFTHNFLPRLGLALSILAIILVFFFLLKKRSFYYPKFIKFFWRAGFL
                     LTLIMYIEMIVELFLMK"
     gene            10337..10837
                     /locus_tag="VVR18_000529"
     CDS             10337..10837
                     /locus_tag="VVR18_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844481.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
                     /protein_id="HEU6032107.1"
                     /translation="MIPYNTLNDYYRKLFGEKTFKVPIDAGFDCPNRDGTVAHGGCTF
                     CTVSGSGDAIVAPDAPIREQFYKEIDFMHRKWPDVQKYLVYFQNFTNTHEKVEVIRER
                     YEQAINEPGVVGINIGTRPDCLPDETIEYLAELSECMHVTVELGLQTTYEATSDLINR
                     AHSYEL"
     gene            10838..11284
                     /locus_tag="VVR18_000530"
     CDS             10838..11284
                     /locus_tag="VVR18_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HEU6032108.1"
                     /translation="METVKRLRKYPKIEIVSHLINGLPGETHEMMVENVRRCVTDNDI
                     QGIKLHLLHLMTNTRMQRDYHEGRLQLMSQDEYVRVICDQLEIIPKHIVIHRITGDAP
                     RDMLIGLMWSLNKWEALNSIEMEMRRRGSVQGCKAVKQEFENEKTT"
     gene            11268..11825
                     /locus_tag="VVR18_000531"
                     /pseudo
     CDS             11268..11825
                     /locus_tag="VVR18_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828405.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
     gene            11818..12072
                     /locus_tag="VVR18_000532"
     CDS             11818..12072
                     /locus_tag="VVR18_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032109.1"
                     /translation="MDKQYLHEKLDAMRQNFVESTHHERSVGVLDQVHMSKKMLKIKK
                     KLVALEMERCQRKIEHKDCSKIDQKIKEQKEIFESCCKKD"
     gene            12084..14138
                     /locus_tag="VVR18_000533"
     CDS             12084..14138
                     /locus_tag="VVR18_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HEU6032110.1"
                     /translation="MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFL
                     PNTDFHLNTELFLALVIGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGL
                     AHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
                     AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIAS
                     ELLLELSLPLVTFFLAEEVHVSGIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHT
                     VTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIVLTFVLFVIRFIMIYGYY
                     AYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTL
                     VSFLTGLLVLPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLPLYAAIDNYH
                     GRIENLILSQENQDDQEDWAALKLLILSIESDGLEQAYEEGNISNRAYRVYQRYLKNI
                     EQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKNKEQSRLRALDYDQIAE
                     LYLANTEMIIESLENLKGVYRRSLISFMQESRLRETTIISSGAFVERVINRVKPNNIN
                     EMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVR
                     RN"
     gene            14317..15177
                     /locus_tag="VVR18_000534"
     CDS             14317..15177
                     /locus_tag="VVR18_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HEU6032111.1"
                     /translation="MKKWWKELIDKPLLKAFLHYYQASDSELTSVAVAYYWLISIFPL
                     LLVVVNILPYFQIPVGEFLGFMKDVLPPSLYEGVEKIAREVLTQPSTGLLSFSVLSAL
                     WSFSKSMNFLQKAFNKAYGVEKSRGLISHQMLSLLVSFGLQLLFAFALFLILFGQMIL
                     ALLAHYWTKDGIIYQALQGLAGPLIYALLFAILVMLYYFLPNLSNRKISYTLPGSAFV
                     LLVILGLLTLFSSYLNYYVHHLVDVRILGSVLLVVMMFWFILIAKIVILGAVINASMQ
                     SLKDPVFKKD"
     gene            15388..16098
                     /gene="ccdA2"
                     /locus_tag="VVR18_000535"
     CDS             15388..16098
                     /gene="ccdA2"
                     /locus_tag="VVR18_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEU6032112.1"
                     /translation="MGHIFFFLSVFLAGILSFFSPCILPLLPVYTGVLLDDKDGAQAS
                     SGKFSISVTSLLRTLAFIAGISFIFILLGYGAGFLGDLLYASWFQYLTGAIIILLGLH
                     QMEILHFKGLYKEKRLQLQGQGQNGKGYSQAFLLGLTFSFAWTPCVGPVLGSVLALAA
                     SGGSGAWQGAGLMLVYTLGLALPFLLLALTSSYVLKHFRKLHPYLGILKKVGGFLIIV
                     MGLLVLFGNASILSQLFE"
     gene            16118..16684
                     /locus_tag="VVR18_000536"
     CDS             16118..16684
                     /locus_tag="VVR18_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HEU6032113.1"
                     /translation="MKKWQTCVLGAGSLLWLTACSGKSVTSEHQTKDEMKTEQTASKT
                     SAAKGKEVADFELMGVDGKTYRLSDYKGKKVYLKFWASWCSICLASLPDTDEIAKEAG
                     DDYVVLTVVSPGHKGEQSEADFKNWYKGLDYKNLPVLVDPSGKLLETYGVRSYPTQAF
                     IDKEGKLVKTHPGFMEKDAILQTLKELA"
     gene            16695..17807
                     /gene="msrB"
                     /locus_tag="VVR18_000537"
     CDS             16695..17807
                     /gene="msrB"
                     /locus_tag="VVR18_000537"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEU6032114.1"
                     /translation="MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQ
                     GGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYEL
                     INQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
                     DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAY
                     PVIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEP
                     LFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGP
                     QDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD"
     gene            18030..18767
                     /locus_tag="VVR18_000538"
     CDS             18030..18767
                     /locus_tag="VVR18_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032115.1"
                     /translation="MTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENGRQAWEL
                     IQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAVKLGVDD
                     YLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLADSQFSL
                     KSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEIAEKVGF
                     EDMNYFTQRFKQIAGVTPRQFKKGEDR"
     gene            18764..20455
                     /locus_tag="VVR18_000539"
     CDS             18764..20455
                     /locus_tag="VVR18_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU6032116.1"
                     /translation="MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGN
                     SQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGIRDLFLTILKSD
                     KDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW
                     VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQH
                     TVYSSSSKMEAMKPYIDTGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQL
                     LWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELR
                     EVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFH
                     DSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINEN
                     VTFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQD
                     AGDSSQSQLKRGGVGLQNVDQRLKLHFGANYQMKIDSRPQKGTKVEIYINRIETS"
     gene            20571..21134
                     /locus_tag="VVR18_000540"
     CDS             20571..21134
                     /locus_tag="VVR18_000540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01440 family protein"
                     /protein_id="HEU6032117.1"
                     /translation="MNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSEVLGGQIG
                     KESSQEIGELIVETILGILSSRGIHLAVQGCEHVNRALVVERQVAEQFGLEIVSVHPT
                     LHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPILREIGHA
                     HVTALASRPKLIGGARAHYPQDAIRKS"
     gene            21156..26843
                     /locus_tag="VVR18_000541"
     CDS             21156..26843
                     /locus_tag="VVR18_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU6032118.1"
                     /translation="MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEII
                     SQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKK
                     IASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLD
                     TVLEETSAKPGEVTVVEVETPQSITNQEQARTENQVVETEEAPKEEAPKTEESPKEEP
                     KSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEES
                     KVEPPVEQAKVPEQPVQPTQAEQPSTPKETSQQENPKEDRGAEETPKQEESTPDTKAE
                     ETVEPKEETKTAKGTQEEDYVGEALVPEQLPEYKVTEGTLVEESTTELDYKTETTEDP
                     TKYTDEETVLRNGEKGSQVTKTTYKTIGGVETDQVLSTSTEVTKEPVNQQVIRGTKPI
                     EGTTVETREEIIPFETKEQEDDTLKRGTRQVTQEGVNDKKQITETYKTIRGEKTSAAP
                     TITETVIEKPQDKIIKNGTKELEKPTLEWAKTDKDVLKKSATASYTLTKPAGVEIKSI
                     KVALKDNTGTVVKEVTVEENNLQATLDNLKYYQGYTLSTTMVYDRGNGEETEILEDKE
                     VQLDLKKVEIKDIKETRLMKVDENGNETDSSLLETVPENLTSYYLKITTNHNKVTRLA
                     ITNIEEVTEEETSLFKVTASAPDLIQRDSNNSLSQTYTYYIEKPKASQNNVYYNFKDL
                     VDAMQKNPNGEFKLGSDLNATNVPTPSKSYVTGKFTGHLTSVDGKHFSIHNTARPLFD
                     RVEGGSIKNINLINVNINMPWANQLASLAQTVKNATVENIKVTGTIVGNNNVAGILDK
                     LDDAGIMTNVAFIGKVQSVGDKGWNLAGIASEIYRGNLNKAYADVELKGLNTRAGAIV
                     GHLAHDFNPRDVGAWSNVRNSVAKGTIDVARGDVGGLIGKDWPWGTIDNNISLVNVKR
                     GDIFFGSNDMDDEFVSNWIKPNNATVIGVSSGDKTHKQSSKIKEISQVEADKKIKDMG
                     ITADTFEVTEHLVDKLNRRILRDEEYKTIQDYNANRELVYRNVEKLQPFYNKEWIVNQ
                     GNKLTTDSPLMNKEVLSVTAMKGNDFITDLTDADHIMVHYADKTKDIFTISPKDSQVK
                     QVKEYSVAELGEVVYTPNMVVKDRADLISAIEGILSPIELQSDPIYQRLGRTGDNRVN
                     AIKNLYLEESFKEVKDHLNTFVTKLVENEDHQLNTDEAAKRALIKKIEDNKAAVLLGL
                     TYLNRYYGVKFDNFNIKELMLFKPDFYGKNVSVLDRLIEIGSKEDYIKGSRTQESFRE
                     VVAKNTLSGNLHDFLTYNMKLFTNETDINVWFKKAIENNAYVVEQPSTNPAFANKKYR
                     LYEGLNNGQHGRMILSLLNLKDAHLFMISTYNTISFSSFEKYGKDTEEKREAFKSEIN
                     KRAKEQVNYLDFWSRLATDNVRDKLLKSQNVVPTPVWDNHGAPGGWPDRFGHRKDKPD
                     YAPIREFFGRIDKYHDYKYGYGAYAYIFADPQPMDAVYFVMSDLISEYGTSAFTHETT
                     HVNDRMAYLGGHRHRQGTDLEAFAQGMLQTPAEHGHQGEYGALGLNMAFERSNDGNQW
                     YNPDPTKLQTRDQIDHYMKNYNEAMMMLDYAEAEAVLPKVKGDNSKWFKKIDRETRRP
                     MDRNKLSGPHQWDKVRDLIDAEKTTNLETIDDLVNNNFMTIHGNPGNKVFHPEDFGTA
                     YVNVNMMAGIYGGNTSQGAPGSLSFKHNAFRMWGYYGYEHGFIDYVSSKHQGAANKEN
                     NGLLGDDFIIKKVSNNQFSNLEDWKKQWYGEVLTKSKKGFAPIEINGTQISTYEQLKT
                     MFDEAVTKDLTELNDSSIKDKYRNTVVLKSKVFKSLLKNTDGFSGDLFTAPQA"
     gene            26912..28633
                     /gene="pabB"
                     /locus_tag="VVR18_000542"
     CDS             26912..28633
                     /gene="pabB"
                     /locus_tag="VVR18_000542"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HEU6032119.1"
                     /translation="MHRKTVIDFRTLGERYTFAQPIKELKTRNVEEVADLLAQVESYQ
                     EQGYYVVGYVSYEAAPAFEEKLAVHKDPLLGEYLLYFTVHDSVETSPIPLTYEDIDLP
                     SNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
                     GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDP
                     KNRSENMMIVDLLRNDMNRISEVGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLV
                     EIFRSLFPCGSITGAPKIATMEIIKNLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQ
                     LHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFED
                     QHLERLRKASRYFAFPFDAEDLGHKIEEECQDCEANQDYRLRISLSKSGEIEVNRQVL
                     TPLSTSFCQAQVCLQEAALNQSFTYFKTTHRPHLSLGEQEKIYHNKSGELLETSIGNL
                     VLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADLTQAEAIYGCNAVRGLY
                     ELSLEEN"
     gene            28634..29251
                     /locus_tag="VVR18_000543"
     CDS             28634..29251
                     /locus_tag="VVR18_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU6032120.1"
                     /translation="MKLIFLHGLEQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQA
                     KERVYQHLAQETEPFVLIGLSLGAALTLELSSYDLPNLRALILSGCPLKLAGNILFYL
                     QLLIFKLLPKRVFEKQGADKTLMVGVSEELKTLDLTDIAGTCSYPTLLICGSKDKPNL
                     SSMKALHRLLTDSQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK"
     gene            29301..30299
                     /locus_tag="VVR18_000544"
     CDS             29301..30299
                     /locus_tag="VVR18_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEU6032121.1"
                     /translation="MNKRLFLKMSLVTLPILALFSQPVLAEENIHFSSCKEAWANGYS
                     DIHEGEPGYSAKLDRDHDGVACELKNAPKGAFKAKQSTAIQINTSSATTSGWVKQDGA
                     WYYFDGNGNLVKNAWQGSYYLKADGKMAQSEWIYDSSYQAWYYLKSDGSYAKNAWQGA
                     YYLKSNGKMAQGEWVYDSSYQAWYYLKSDGSYARNAWQGNYYLKSDGKMAKGEWVYDA
                     TYQAWYYLTSDGSYAYSTWQGNYYLKSNGKMAVNEWVDGGRYYVGADGVWKEGQASTV
                     SSSNDSNSEYSAALGKAKSYNSLFHMSKKRMYRQLTSDFDKFSNDAAQYAIDHLDD"
     gene            30426..31385
                     /locus_tag="VVR18_000545"
     CDS             30426..31385
                     /locus_tag="VVR18_000545"
                     /EC_number="2.7.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002919069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family glucokinase"
                     /protein_id="HEU6032122.1"
                     /translation="MSQKIIGIDLGGTSIKFAILTTAGEIQGKWSIKTNILDEGSHIV
                     DDMIESIQHRLDLLGLAAADFQGIGMGSPGVVDREKGTVIGAYNLNWKTLQPIKQKIE
                     KALGIPFFIDNDANVAALGERWMGAGDNQPDVVFMTLGTGVGGGIVAEGKLLHGVAGA
                     AGELGHITVDFDQPIACTCGKKGCLETVASATGIVNLTRRYADEYEGDAALKRLIDNG
                     EEVTAKTVFDLAKEGDDLALIVYRNFSRYLGIACANIGSILNPSTIVIGGGVSAAGEF
                     LLQGVQKVYDENSFPQVRTSTKLALATLGNDAGVIGAASLVLQ"
     gene            31482..32321
                     /locus_tag="VVR18_000546"
     CDS             31482..32321
                     /locus_tag="VVR18_000546"
                     /EC_number="2.1.1.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate synthase"
                     /protein_id="HEU6032123.1"
                     /translation="MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAF
                     SEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDT
                     GTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMF
                     DVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNL
                     HIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFD
                     LAI"
     gene            complement(32369..32539)
                     /locus_tag="VVR18_000547"
     CDS             complement(32369..32539)
                     /locus_tag="VVR18_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001051775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3042 family protein"
                     /protein_id="HEU6032124.1"
                     /translation="MAKGFAKGLVTGVAGTVAAVAGAVYAFKKKVIEPEEQKAAFIEE
                     NRKKAARRRVSR"
     gene            32660..33544
                     /gene="miaA"
                     /locus_tag="VVR18_000548"
     CDS             32660..33544
                     /gene="miaA"
                     /locus_tag="VVR18_000548"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HEU6032125.1"
                     /translation="MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLD
                     IGTAKASPEEQAAVPHHLIDVREITESYSAFDFVSEAKMTIEGIHNRGKLAIIAGGTG
                     LYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHLVEQAGLEIPQFNRRRAMRA
                     LEIAHFGQDLENQEILYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHS
                     PNVQAAKGIGYKELFPYFRGEQTLEEARESLKQATRRFAKRQLTWFRNRMQVTFYQIG
                     ESGVQDRILSQIEEFLDD"
     gene            33537..34775
                     /gene="hflX"
                     /locus_tag="VVR18_000549"
     CDS             33537..34775
                     /gene="hflX"
                     /locus_tag="VVR18_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HEU6032126.1"
                     /translation="MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVD
                     SYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVI
                     DRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQ
                     LELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNIL
                     TSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESK
                     HVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFMPTQTPYT
                     LISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDG
                     EVITGYISEKNKWRLEEFYD"
     gene            34768..35391
                     /locus_tag="VVR18_000550"
     CDS             34768..35391
                     /locus_tag="VVR18_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine beta-lyase"
                     /protein_id="HEU6032127.1"
                     /translation="MTDIKTLALKYGGYTSLDKVYLDQLLAGKTEQEQLTLITPPPSV
                     VNAYFAELYQKKSPQAATDYFAELSQELNLYNTEPSFTLENKSFIRLNLSGKSFGFCY
                     ESDGFGRIFSENEEKISDDLLFEIAQIFPHQLVFEESGKIYMKPVEDEEVVSLESLTA
                     LTDLERLADGRKRLKGYSQEDLLQEAAAFSGKRYFRSENRTAMLYID"
     gene            35406..36335
                     /locus_tag="VVR18_000551"
     CDS             35406..36335
                     /locus_tag="VVR18_000551"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HEU6032128.1"
                     /translation="MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQN
                     RILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFV
                     LTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
                     GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTR
                     KTDASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHIS
                     ARFLSKDISKLKKDAATIFENVHVVKDLEEVEI"
     gene            36356..37111
                     /locus_tag="VVR18_000552"
     CDS             36356..37111
                     /locus_tag="VVR18_000552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HEU6032129.1"
                     /translation="MPTILITGASGGLAQEMVKLLPNDQLILLGRNKEKLAQLYGNYS
                     HAELIEIDITDDSALEALVTDLYLRYGKIDVLINNAGYGIFEGFDQIADKDIHQMFEV
                     NTFALMNLSRHLAARMKESSKGHIINIVSMAGLIATGKSSLYSATKFAAIGFSNALRL
                     ELMPYGVYVTTVNPGPIRTGFFDQADPDGTYLKSVDRFLSEADAVAKKIVKIIGKNKR
                     ELNLPILLNLAHKFYTLFPKLADKLAGETFNYK"
     gene            complement(37165..38073)
                     /locus_tag="VVR18_000553"
     CDS             complement(37165..38073)
                     /locus_tag="VVR18_000553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEU6032130.1"
                     /translation="MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLENEMG
                     IEIFIRNPKGITLTRDGMEFLSYARQVVEQTQLLEERYKNPVAHRELFSVSSQHYAFV
                     VNAFVSLLKKSDMEKYELFLRETRTWEIIDDVKNFRSEVGVLFLNSYNRDVLTKMLDD
                     NHLLSHHLFTAQPHIFVSKTNPLAKKDKVKLSDLENFPYLSYDQGTHNSFYFSEEILS
                     QEHHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDIDDPIELVYI
                     QHEKTSLSKMGERFIDYLLEEVQFDS"
     gene            38137..38406
                     /locus_tag="VVR18_000554"
     CDS             38137..38406
                     /locus_tag="VVR18_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqgQ family protein"
                     /protein_id="HEU6032131.1"
                     /translation="MSLFLKKTQNFARMSLMKTFYDVQQFLKRFGIIVYMGKRLYDIE
                     LMKLELSRIYDAGLMDKLDYLEAEAVLRREHKVELDYIEKNGEKN"
     gene            38406..38786
                     /locus_tag="VVR18_000555"
     CDS             38406..38786
                     /locus_tag="VVR18_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU6032132.1"
                     /translation="MVTWILWALILAMLAWMGFNYLRIRRAAKIVDNEEFEALIRTGQ
                     LIDLRDPAEFHRKHILGARNIPSSQLKTSLAALRKDKPVLLYENQRAQRVTNAALYLK
                     KQGFSEIYILSYGLDSWKGKVKTS"
     gene            38875..39102
                     /locus_tag="VVR18_000556"
     CDS             38875..39102
                     /locus_tag="VVR18_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032133.1"
                     /translation="MKEKKKNPLFVGILSIILGLLFPIVGLILGIIGLVLAISYQKES
                     QLDYKIEKILNILGIVISVVNWIVAIALIFR"
     gene            complement(39142..39867)
                     /locus_tag="VVR18_000557"
     CDS             complement(39142..39867)
                     /locus_tag="VVR18_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001235004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HEU6032134.1"
                     /translation="MRLDNLLAQEKISRKAMKQALLKGDILVDSCPARSLAQNIDTGL
                     QELLFQDRIIQGYEHTYLMLHKPAGVVTANKDKELPTVMDLLPSDIQSDKLYAVGRLD
                     RDTTGLLLLTDNGPLGFQLLHPQYHVDKTYQVQVNGLLTPDHIQAFQKGIVFLDGTVC
                     KPAKLEILSASPSLSQASITISEGKFHQIKKMFLSVGVKVTSLKRIQFGDFTLNPDLA
                     ESNYRPLNQKELQIIKNYLEMSR"
     gene            40029..41870
                     /gene="typA"
                     /locus_tag="VVR18_000558"
     CDS             40029..41870
                     /gene="typA"
                     /locus_tag="VVR18_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003078415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HEU6032135.1"
                     /translation="MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAER
                     AMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVV
                     DAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQ
                     LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLD
                     YNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAG
                     DLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSR
                     KVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEV
                     IVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPA
                     RGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMS
                     IEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPR
                     ILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE"
     gene            41890..42144
                     /locus_tag="VVR18_000559"
     CDS             41890..42144
                     /locus_tag="VVR18_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3165 family protein"
                     /protein_id="HEU6032136.1"
                     /translation="MVYLVLGILLLLLYVFATPESIKGTVNIVAMVCILVALLILLVL
                     SFLKIFQLPTEIFLAIAMLILAYFSVRDITLMPVKKSKRR"
BASE COUNT        12934 a         7913 c         9418 g        12013 t
ORIGIN      
        1 ccaatcttat tccgtatccc agcaatgagc gctccagtat ttgacaatat tgaagcagct
       61 attaaagaac acggattaag ctaattctaa tttgttaaca ttcatataac ataaaaaagg
      121 gaggaactgt tatggatgca atctttgacc taatcggaaa ggttttcaat cccatcttag
      181 aaatgggtgg acctgtcatc atgttaatca ttttgacagt attggcttta ctttttggag
      241 tgaaattctc caaagcgctt gaaggtggta tcaaacttgc catcgctctt acaggtatcg
      301 gtgctatcat cggtatgcta aatggtgctt tctcagcatc acttgcaaaa ttcgttgaaa
      361 acactggtat ccaattgagt attacagacg ttggttgggc accactcgca acaatcactt
      421 ggggttctgc ttggacacta tacttcttgc tcatcatgtt gattgtcaac gtagtgatgc
      481 ttgctatgaa gaaaaccgat acacttgatg tcgatatctt tgatatctgg cacttgtcta
      541 tcacaggtct cttgattaaa tggtatgctg ataacaatgg tgtgagtcaa ggggtttcac
      601 tctttattgc tacagcagct atcgtccttg tcggtgtgtt gaaaattatc aactctgact
      661 tgatgaaacc tacatttgat gaccttctta acgccccaag ttcatcacca atgacatcaa
      721 ctcacatgaa ctacatgatg aacccagtta tcatggtttt ggataagatt tttgaaaaat
      781 tcttcccagg ccttgataaa tatgactttg atgctgctaa attgaacaag aaaatcggtt
      841 tctggggatc taaattcttc atcggtttca tccttggtat cgttatcggt attatgggaa
      901 ctccacatcc aattgcaggt gttgcagatg cagataaatg gcgtcttgtt atcaaaggat
      961 ggttgtctct tggtttgact gccggtgtat ctttggaact cttctcactt atcggttcat
     1021 ggttcatcgc agccgtagaa ccactatcac aaggtattac aaacgttgct actaaacgtc
     1081 ttcaaggacg taaattcaat atcggtcttg actggccatt catcgctggt cgtgctgaaa
     1141 tctgggcttg tgccaacgta cttgcaccaa tcatgttgat tgaagcagtg cttctttcaa
     1201 aagttggaaa tggtatcttg ccacttgcag gtatcatcgc tatgggtgtt actccagctc
     1261 tcttggttgt aactcgtggt aaattgctcc gtatgattat cttcggaaca ctcttgttgc
     1321 cactcttcct tctttcaggt acccttattg caccatttgc aacagaactt gctaaaggtg
     1381 taggtgcctt cccagaaggt gtgagccaaa ctcaattgat tactcactct actcttgaag
     1441 gaccaatcga aaaacttctt ggttggacaa ttggtaacac tacaactggt gatatcaaag
     1501 caatccttgg tgcagtagcc ttccttgtat tctatatcgg tatctttgct tggtacagaa
     1561 aacaaatgat caaacgtaac gaagagtacg cagcaaaagc aaaataatgc gctcctataa
     1621 aatataaact caatgaaaat caaagagcaa actaggaagc tagccgcagg ttgctcaaaa
     1681 cacagttttg aggttgtaga tgaaactgac gaagtcagta atcatatcta cggcaaggcg
     1741 acactgacga agtttgaatt ggattttcgc agagtgtaaa ttgttgaaac taggttgtca
     1801 taccatgtat accacttggg ctttggtagt agctaactgc actaaatata atataaggag
     1861 ggttttatgg ggaaaggcca ttggaatcgg aaaagagttt atagcattcg taagtttgct
     1921 gtgggagctt gctcagtaat gattgggact tgtgcagttc tattaggagg aaatatagct
     1981 ggagaatctg tagtttatgc ggatgaaaca cttattactc atactgctga gaaacctaaa
     2041 gaggaaaaaa tgatagtaga agaaaaggct gataaagctt tggaaactaa aaatgtagtt
     2101 gaaaggacag aacaaagtga acctagttca actgaggcta ttgcatctga gaagaaagaa
     2161 gatgaagccg taactccaaa agaggaaaaa gtgtctgcta aaccggaaga aaaagctcca
     2221 aggatagaat cacaagcttc aaatcaagaa aaaccgctca aggaagatgc taaagctgta
     2281 acaaatgaag aagtgaatca aatgattgaa gacaggaaag tggattttaa tcaaaattgg
     2341 tattttaaac tcaatgcaaa ttctaaggaa gccattaaac ctgatgcaga cgtatctacg
     2401 tggaaaaaat tagatttacc gtatgactgg agtatcttta acgatttcga tcatgaatct
     2461 cctgcacaaa atgaaggtgg acagctcaac ggtggggaag cttggtatcg caagattttc
     2521 aaactagatg aaaaagacct caagaaaaat gttcgcctta cttttgatgg cgtctacatg
     2581 gattctcaag tttatgtcaa tggtcagtta gtggggcatt atccaaatgg ttataaccag
     2641 ttctcatacg atatcaccaa ataccttcac aaagatggtc gtgagaatgt gattgctgtc
     2701 catgcagtca acaaacagcc aagtagccgt tggtattcag gaagtggtat ctatcgtgat
     2761 gtgactttac aagtgacaga taaggtgcat gttgagaaaa atgggacaac tattttaaca
     2821 ccaaaacttg aagaacaaca acatggcaag gttgaaactc atgtgaccag caaaatcgtc
     2881 aatacggacg acaaagacca tgaacttgta gccgaatatc aaatcgttga acgaggtggt
     2941 catgctgtaa caggcttagt tcgtacagcg agtcgtacct taaaagcaca tgaatcaaca
     3001 agcctagatg cgattttaga agttgaaaga ccaaaactct ggaccgtttt aaatgacaaa
     3061 cctgccttgt acgaattgat tacgcgtgtt taccgtgacg gtcaattggt tgatgctaag
     3121 aaggatttgt ttggttaccg ttactatcac tggactccaa atgaaggttt ctctttgaat
     3181 ggtgaacgta ttaaattcca tggagtatcc ttgcaccacg accatggggc gcttggagca
     3241 gaagaaaact ataaagcaga atatcgccgt ctcaaacaaa tgaaggagat gggagttaac
     3301 tccatccgta caacccacaa cccttctagt gagcaaacct tgcaaatcgc agcagaacta
     3361 ggtttacttg ttcaggaaga ggcctttgat acgtggtatg gtggcaagaa accttatgac
     3421 tatggacgtt tctttgaaaa agatgccact cacccagaag ctcgaaaagg tgaaaaatgg
     3481 tctgattttg acctacgtac catggtcgaa agaggcaaaa acaaccctgc tatcttcatg
     3541 tggtcaattg gtaatgaaat aggtgaagct aatggtgatg cccactcttt agcaactgtt
     3601 aaacgtttgg tcaaggttat caaggatgtt gataagactc gctatgttac catgggagca
     3661 gataaattcc gtttcggtaa tggtagcgga gggcatgaga aaattgctga tgaactcgat
     3721 gctgttggat ttaactattc tgaagataat tacaaagccc ttagagctaa gcatccaaaa
     3781 tggttgattt acggttcaga aacatcatca gcaacccgta cacgtggaag ttactatcgc
     3841 cctgaacgtg aattgaaaca tagcaatgga cctgagcgta attatgaaca gtctgactat
     3901 gggaatgatc gtgtgggttg ggggaaaaca gcaaccgctt catggacttt tgaccgtgac
     3961 aacgctggct atgctggaca gtttatctgg acaggtacgg actatattgg tgaacctaca
     4021 ccatggcaca accaaaatca aactcctgtt aagagctctt actttggtat cgtagataca
     4081 gccggcattc caaaacatga cttctatctc taccaaagcc aatgggtttc tgttaagaag
     4141 aaaccgatgg tacaccttct tcctcactgg aactgggaaa acaaagaatt agcatccaaa
     4201 gtagctgact cagaaggtaa gattccagtt cgtgcttatt cgaatgcttc tagtgtagaa
     4261 ttgttcttga atggaaaatc tcttggtctt aagactttca ataaaaaaca aaccagcgat
     4321 gggcggactt accaagaagg tgcaaatgct aatgaacttt atcttgaatg gaaagttgcc
     4381 tatcaaccag gtaccttgga agcaattgct cgtgatgaat ctggcaagga aattgctcga
     4441 gataagatta cgactgctgg taagccagcg gcagttcgtc ttattaagga agaccatgcg
     4501 attgcagcag atggaaaaga cttgacttac atctactatg aaattgttga cagccagggg
     4561 aatgtggttc caactgctaa taatctggtt cgcttccaat tgcatggcca aggtcaactg
     4621 gtcggtgtag ataacggaga acaagccagc cgtgaacgct ataaggcgca agcagatggt
     4681 tcttggattc gtaaagcatt taatggtaaa ggtgttgcca ttgtcaaatc aactgaacaa
     4741 gtagggaaat tcacccttac tgcccactct gatctcttga aatcgaacca agtcactgtc
     4801 tttactggta aaaaagaagg acaagagaag actgttttgg ggacagaagt gccaaaagta
     4861 cagaccatta ttggagaggc acctgaaatg cctaccactg ttccgtttgt atacagtgat
     4921 ggtagccgtg cagaacgtcc tgtaacctgg tcttcagtag atgtgagcaa gcctggtatt
     4981 gtaacggtga aaggtatggc tgacggacga gaagtagaag ctcgtgtaga agtgattgct
     5041 cttaaatcag agctaccagt tgtgaaacgt attgctccaa atactgactt gaattctgta
     5101 gacaaatctg tttcctatgt tttgactgat ggaagtgtac aagagtacga agtagatagc
     5161 tgggagattg ccgaagaaga taaagttaag ttagcaattc caggttctcg tattcaagcg
     5221 accggttatt tagaaggtca accaattcat gcaacccttg tggtagaaga aggcaatcct
     5281 gcagcacctg tagtgccaac tgttactgtt ggaggtgaag cagtaacagg tcttactagt
     5341 cgacaaccaa tgcaatatcg tactctatct tatggtgccc aattgccaga agtcacagca
     5401 agtgctgaaa atgctgatgt gacagttctt caagcaagcg cagcaaacgg catgcgtgcg
     5461 agcatcttta ttcagcctaa agatggtggc cctcttcaaa cctatgcaat tcaattcctt
     5521 gaagaagcgc caaaaattgc tcacttgagc ttgcaagtgg aaaaagctga cagtctcaaa
     5581 gaagaccaaa ctgtcaaatt gtcggttcga gctcactatc aagatggaac gcaagctgta
     5641 ttaccagctg ataaagtaac cttctctaca agtggtgaag gggaagtcgc aattcgtaaa
     5701 ggaatgcttg agttgcataa gccaggagca gtcactctga acgctgaata tgagggagct
     5761 aaaggccaag ttgaactcac tatccaagcc aatactgaga agaagattgc gcaatccatc
     5821 cgtcctgtaa atgtagtgac agatttgcat caggaaccaa gtcttccagc aacagtaaca
     5881 gttgagtatg acaaaggttt ccctaaaact cataaagtca cttggcaagc tattccgaaa
     5941 gaaaaactag actcctatca aacatttgaa gtactaggta aagttgaagg aattgacctt
     6001 gaagcgcgtg caaaagtctc tgtagaaggt atcgtttcag ttgaagaagt cagtgtgaca
     6061 actccaatcg cagaagcacc acaattacca gaaagtgttc ggacatatga ttcaaatggt
     6121 cacgtttcat cagctaaggt tgcatgggat gcgattcgtc cagagcaata cgctaaggaa
     6181 ggtgtcttta cagttaatgg tcgcttagaa ggtactcaat taacaactaa acttcatgtt
     6241 cgcgtatctg ctcaaactga gcaaggtgca aacatttctg accaatggac cggttcagaa
     6301 ttgccacttg cctttgcttc agactcaaat ccaagcgacc cagtttcaaa tgttaatgac
     6361 aagctcattt cctacaataa ccaaccagcc aatcgttgga caaactggaa tcgtagtaat
     6421 ccagaagctt cagtcggtgt tctgtttgga gattcaggta tcttgagcaa acgctccgtt
     6481 gataatctaa gtgtcggatt ccacgaagac catggagttg gtgcaccgaa gtcttatgtg
     6541 attgagtatt atgttggtaa gactgtccca acagctccta aaaaccctag ttttgttggt
     6601 aatgaggacc atgtctttaa tgattctgcc aactggaaac cagttactaa tctaaaagcc
     6661 cctgctcaac tcaaggctgg agaaatgaac cactttagct ttgataaagt tgaaacctat
     6721 gctgttcgta ttcgcatggt taaagcagat aacaagcgtg gaacgtctat cacagaggta
     6781 caaatctttg cgaaacaagt tgcggcagcc aaacaaggac aaacaagaat ccaagttgac
     6841 ggcaaagact tagcaaactt caaccctgat ttgacagact actaccttga gtctgtagat
     6901 ggaaaagtta cggcggtcac agcaagtgtt agcaacaatg gtctcgctac cgtcgttcca
     6961 agcgttcgtg aaggtgagcc agttcgtgtc atcgcgaaag ctgaaaatgg cgacatctta
     7021 ggagaatacc gtctgcactt cactaaggat aagaacttac tttctcataa accagttgct
     7081 gcggttaaac aagctcgctt gctacaagta ggtcaagcac ttgaattgcc gactaaggtt
     7141 ccagtttact tcacaggtaa agacggctac gaaacaaaag acctgacagt tgaatgggaa
     7201 gaagttccag cggaaaatct gacaaaagca ggtcaattta ctattcgagg ccgtgtcctt
     7261 ggtagtgacc ttgttgctga ggtcactgta cgagtgacag acaaacttgg tgaggctctt
     7321 tcagataacc ctaactatga tgaaaacagt aaccaggcct ttgcttcagc aacaaatgat
     7381 attgacaaaa actctcatga ccgcgttgac tatctcaatg acggagatca ttcagaaaat
     7441 cgtcgttgga caaactggtc accaacacca tcttctaatc cagaagtatc agcgggtgtg
     7501 atcttccgtg aaaatggtaa gattgtagaa cggactgttg ctcaagccaa acttcacttc
     7561 tttgcagata gtggtacgga tgcaccaact aaactcgttt tagaacgcta tgtcggtcca
     7621 gagtttgaag tgccaaccta ctattcaaac taccaagcct acgacgcaga ccatccattc
     7681 aacaatccag aaaattggga agctgtgcct tatcgtgcgg ataaagacat cgcagctggt
     7741 gatgaaatca acgtaacatt taaagctgtc aaagccaaag ctatgagatg gcgtatggag
     7801 cgtaaagcag ataagagcgg tgttgcgatg attgagatga ccttccttgc accaagtgaa
     7861 ttgcctcaag aaagtacgca atcgaagatt cttgtagatg gaaaagaact tgctgatttc
     7921 gctgaaaatc gtcaagacta tcaaattacc tataaaggtc aacggccaaa agtctcagtt
     7981 gaagaaaaca atcaagtagc ttcaactgtg gtagatagtg gagaagatag ccttccagta
     8041 cttgttcgcc tcgtttcaga aagtggaaaa caagtcaagg aataccgtat ccagttgact
     8101 aaggaaaaac cagtttctgc tgtacaagaa gatcttccaa aactcgaatt tgttgaaaaa
     8161 gatttggcct acaagacagt tgagaaaaaa gattcaacac tgtatctagg tgaaactcgt
     8221 gtagaacaag aaggaaaaac tggtaaagaa cgtatcttta cagcgattaa tcctgatgga
     8281 agtaaggaag aaaaactccg tgaagtggta gaagctccga cagaccgcat cgtcttggtt
     8341 ggaaccaaac cagtagctca agaagctaaa aaaccacaag tgtcagaaaa agcagataca
     8401 aaaccaattg attcaagtga agctagtcaa actaataaag cccagttacc aaatacaggt
     8461 agtgcggcaa gccaagcagc agtagcagca ggtttagctc ttctaggttt gagtgcagga
     8521 ttagtagtta ctaaaggtaa aaaagaagac tagaaatttt gataccttct ttatcattaa
     8581 agaccaaaga aaaactcttg tcctaaatag aagataaaga gtctggaaca aaatagttct
     8641 caaccacaaa aaagctagat atttccaatt gcggaactct agctttttaa ttttgagtcg
     8701 ttctcttatt gtatagtaga ttgaaactag agtagtacac ttctacttct aaaacattgt
     8761 tagaaatcga tttgactgtc cttatcgatt tgtcctgttc ttatttcatt tcactatgtt
     8821 ttaggaggtt attggccata agtaccaatc ccatgtcaat tctcacttga cgcttgcctc
     8881 tcagattaca tctcttgtaa cccaaacaag cctttatctg cccaaagaca ggttccacat
     8941 caatcttgcg ttgagcgaaa atctgtctat cttggggaga taaaagcgcc tgacattctt
     9001 tagctttcaa gttttgatag cgttcgttca tatacagtcc cttttgaggg gctgattcag
     9061 gttcatcagc gtagtaaacc ttgatttcct gttgaaagtc tgtctgtgtt ttctgatgtt
     9121 tggtatggtg aaaacgataa taccagccat caggatgtgt gtagctatcc tccttgtcat
     9181 tatagtgcca attcgctaag tttttagctg actgtttata ccctctcttt tgttccttat
     9241 caaacatggc atatttaatc aggaggggag tgatttcttc ttgaaaatag acttgtattt
     9301 gttcttgaag tttggcggag aatttctctg tcgttttctt ccacacaaaa ctatacttgt
     9361 tggcattggc ttcaatctta gttccgtcaa taaacaaaca atctaaggtc actaactctt
     9421 ccatttttca atttttcgac cagagaaaat cccttgtgaa taggcaaata gaagagtaga
     9481 tacaagcatt ttagggtgat aagacgggcg accaaaggca tgatagaagg cgtagaagtg
     9541 acgttcctcc aaggtattca ccactttttc aatagtaaag acgagatggt cttgtggtaa
     9601 gaaggaactg atttctagtg gtaaagttgt ttgatttgtg ttatagtgaa tatgcatggg
     9661 atagcctttc taaatggttt attaagcaat tctattttac caagactatc gtaaccatgc
     9721 aaaaaagcaa cggcaaatcc gttgcctttt tggatataag agactattgt cccagactct
     9781 tttctttgta taaaattgta tagtgttatt gtctatacta ttttgtagag aaagcaaaaa
     9841 tccctagaaa atgcttaggg attcgactat ttcattaaga acaattcaac aatcatttct
     9901 atatacatga taagggttaa taagaatcct gcacgccaga agaatttgat gaatttagga
     9961 tagtaaaagc tgcgtttttt caaaaggaag aaaaagacga gaataatggc taggatcgag
    10021 agggctagcc ccagtctagg gaggaaatta tgggtaaagg ttttagctgt aatcaagtaa
    10081 tactcaaata ccaagactgg aaaagccaaa tccgcaaagt ttcgtcctag tttttttaat
    10141 ctaaaaagtt tggttaggat aatgcagatg actaaggtca gtatcaataa taaaatagat
    10201 gctaatttca ttaaaatcat acccatattg tatcataaaa aaaggctaat ggaaacgaga
    10261 aacagaggaa tttataggaa agtcaggctt ttgagattgt gggtgatttt tgttataatg
    10321 aaagttataa aatcttataa taccttataa taccttgaat gattattatc gaaaactctt
    10381 tggagaaaag acttttaaag tccctattga tgcgggattt gactgtccca atcgtgatgg
    10441 aactgtggct catggaggct gtactttttg tacggtttca ggttctggag atgctattgt
    10501 agccccagat gcgcctatcc gtgagcaatt ttataaggaa attgacttta tgcaccgtaa
    10561 gtggccggat gttcagaagt atctggttta ttttcaaaat tttaccaaca cccatgaaaa
    10621 ggtggaagtt attcgagagc gttatgaaca ggctatcaat gagccaggtg tggtaggaat
    10681 caatattgga acgcgcccag actgtttacc agacgaaacc atcgaatatt tggctgagtt
    10741 atcggagtgc atgcatgtga cggttgaatt gggcttgcaa actacttatg aagcaacctc
    10801 tgacctgatt aaccgtgcgc attcttatga attgtaggtg gaaacggtca agcgtttgag
    10861 aaagtatcca aaaattgaga ttgtttccca tttgatcaat ggtttgcctg gtgaaaccca
    10921 tgagatgatg gttgaaaatg tccgccgttg tgtcacggat aacgatattc aagggattaa
    10981 actgcatttg ctccatctta tgacaaatac tcgtatgcaa cgagattacc atgagggacg
    11041 tttacaattg atgagtcagg acgaatatgt cagggtcatc tgtgaccaac tggaaattat
    11101 tcccaaacat atcgtcatcc atcgaatcac aggagatgca cctagggata tgctgattgg
    11161 gcttatgtgg agcctcaata aatgggaagc tctcaacagc attgagatgg agatgcgacg
    11221 tcgtggaagt gttcaaggat gcaaggctgt aaaacaggag tttgaaaatg aaaagaccac
    11281 ttgagatggc acatgatttt ttggctgagg tcgtgacaaa agaggatgtc gtagtggatg
    11341 cgactatggg aaatggtcat gacacgcttt ttttagccaa gctagccaag caagtctatg
    11401 cctttgatat tcagaagcaa gccttggaaa agacccaaga gcgtttgcat caggctggct
    11461 tgacaaatgc ccagttaatc ttgcaaggcc atgagacact ggaccagttt gtgacaaaag
    11521 ctaaggcagg gatttttaat ctgggctatt tgccgtcagc tgataagtct atcatcaccc
    11581 gaccgcagac aacgattgag gcattaggaa agctatgtgg cttacttgtc aaaggtggac
    11641 gaattgctat tatgatttac tatggtcatg aaggaggcga cctcgagaga gatgctgtct
    11701 tggattttgt aatccagttg aactaacaag agtacacagc tgccatttac cgaactttaa
    11761 accaagtcaa caacccgccg tttttagtga tgattgaaaa attagagaga tacagacatg
    11821 gataaacaat acctacacga aaagctggat gccatgcgcc agaattttgt tgaatcaacc
    11881 caccacgaac gatcggtggg cgtgctagac caagtacata tgagcaaaaa aatgcttaaa
    11941 atcaagaaaa aattagttgc tcttgaaatg gaacggtgcc agagaaaaat tgagcacaaa
    12001 gactgttcca agattgacca aaaaatcaaa gagcagaagg agatatttga atcctgttgt
    12061 aaaaaagatt aaggaggacg tgcgtggaat tactgattta cctcatccta tttttactgg
    12121 ttttgattgt ctcaagtaca accaataagc tcctgccctt tttgcctctc cctttggtgc
    12181 agattctttt gggaattgtg attggtctct ttttacccaa tactgacttt caccttaata
    12241 cggagttgtt tttggcactg gttatcggac ccttgctttt ccgagaggct gaagaagcag
    12301 atgttacggc tattttaaaa cactggcgaa tcattgttta tctcatattt ccagtgattt
    12361 ttatctcgac cctgagtttg ggtggcttgg cccatcttct ttggttcagc cttcccttgg
    12421 cagcttgctt ggctgttggg gcagcccttg gtcctacgga cttggtggcc tttgcctctc
    12481 tttcggagcg ttttagcttt cctaagcgcg tgtccaatat tcttaagggc gaaggactct
    12541 tgaatgatgc ttctggtttg gtggcttttc aggtagcttt gacagcttgg acaactggag
    12601 ctttttctct ggggcaagct agcagttcgc tcatcttttc aatcctaggc ggttttttaa
    12661 ttggattttt aacagccatg accaaccgct tcctccatac cttcttgcta agtgtgcgcg
    12721 caacggatat tgccagtgaa cttttattag aattgagttt gcctctagtg accttctttc
    12781 tggcagaaga agtccatgtt tcagggatta ttgccgtcgt agttgctgga attttaaagg
    12841 caagtcgctt caagaaaatc acgctcctcg aagcccaagt ggatacggtg accgagacgg
    12901 tctggcatac agtgaccttt atgctcaacg gttctgtctt tgtgatttta gggatggagt
    12961 tggaaatgat agcagaacct atcttgacca atccaatcta taatcctcta cttttattgc
    13021 tatctctcat cgtccttacc tttgtcctct ttgtcattcg ttttattatg atctatggct
    13081 attatgccta tagaacccga cgcctcaaga aaaagctaaa taagtatatg aaggacatgt
    13141 ttctcttgac cttttcaggt gttaagggaa cggtgtcgat tgctacgatt ctcttgatac
    13201 caagtaatct agaacaggag tatcctctct tgcttttcct tgttgcaggt gtgacgcttg
    13261 tcagcttttt aacaggtctc ttggtcttgc ctcatctttc tgatgaagag gaagaaagca
    13321 aggattatct catgcatatc gccattttga atgaagtaac gctagagttg gaaaaagagt
    13381 tggaagacac cagaaataaa cttcccctct atgcggctat tgacaattat catggacgta
    13441 ttgaaaatct cattttaagc caagaaaacc aggatgatca agaagattgg gctgctttga
    13501 aactcttgat tcttagtatt gaaagtgatg gtttggaaca ggcctatgaa gaggggaaca
    13561 ttagcaatcg tgcttaccga gtttaccaac gttatctgaa aaatatagaa caaggaatca
    13621 atcgtaaact tgcctcaaga ctgacctatt atttccttgt ttctttgcgg attttacgtt
    13681 ttctccttca tgaagttttt actctcggaa agaccttccg tagctggaag aacaaggagc
    13741 aaagccgtct ccgtgctctt gattatgacc aaattgcaga gctctatctt gccaatacgg
    13801 agatgattat tgaaagtttg gaaaacctga agggagtcta cagacgctct ttgattagtt
    13861 ttatgcagga gtctcgtctt cgagaaacaa ctattatcag cagtggtgcc tttgtcgaac
    13921 gggttatcaa tcgtgtcaaa cccaacaata tcaatgaaat gctgagaggc tattatctgg
    13981 agcgcaagtt gattttcgaa tacgaagaaa aacgattaat tacaactaag tatgccaaga
    14041 aattacgaca aaatgtaaat aacttagaga actattcctt gaaggaagct gccaataccc
    14101 tgccgtatga tatggtggaa ttggtaagaa gaaattagtt aatactcttc gaaaatctct
    14161 tcaaaccatg tcagcgtcgc cttaccgtat atatgtgact gacttcgtca gtcttatcta
    14221 caacctcaaa acagtgtttt gagcagcctg cggctagctt tctagtttgc tctttgattt
    14281 tcattgagta taagattata aatgaaggag tatgacatga aaaagtggtg gaaagagctg
    14341 atagacaagc ctttattaaa agcttttttg cattattatc aagcatcaga tagtgagttg
    14401 accagtgtcg cagtagccta ctattggttg atttcgattt tccccctgct tttggtggtg
    14461 gtcaatatcc tcccctattt tcagattcct gtgggagaat ttctgggctt tatgaaagac
    14521 gtcctgcccc caagcctcta tgaaggtgtg gaaaaaatag ccagagaagt cttgacgcaa
    14581 ccttcaacag gtttattgag tttttctgtt ttatcggcgt tatggagttt ttcaaaatct
    14641 atgaatttct tgcaaaaagc ttttaacaag gcttatggcg tcgaaaagag tcgtggactt
    14701 atttcccatc agatgctaag tctcctagtc agttttggct tgcagctcct ctttgcgttt
    14761 gccttgtttt tgatcttatt tggtcagatg attttggctt tacttgctca ttattggaca
    14821 aaagatggca ttatctatca ggctttacaa gggttggcag gtcctctgat ttacgccctc
    14881 ctctttgcta tcttggtcat gctttattat tttcttccca atctatctaa caggaaaatt
    14941 agctataccc taccaggcag tgcctttgtt ctcttagtga ttttaggttt actaactctg
    15001 ttctctagtt atctcaatta ctatgtccat catttggtgg atgtccgaat tttaggttcc
    15061 gttcttcttg ttgttatgat gttttggttt atcttgattg ctaaaattgt tatcctaggc
    15121 gcggtgatca atgccagtat gcagagtttg aaagatccgg tctttaaaaa agactaacta
    15181 tttatccatt acaaaagcgc atagtatcaa ggctttatag aatcttgata ctatgcgctt
    15241 ttgtgctttg acagtttttt gtatagtttt tgtccaagat ttctaaatca tctgattaaa
    15301 ttcctatttt cccctatcat tgtccctgtt ttttcgaaaa tggaaggagt ataataaatc
    15361 tatcaataaa atgataggag gaactttatg ggtcatattt tcttttttct aagtgtcttt
    15421 ttggcaggga ttctatcctt cttttctcct tgtatcttac ctttgttacc ggtctataca
    15481 ggagtgttac tagatgataa ggatggtgct caggcttcta gcggcaaatt ttcaatctca
    15541 gttactagtt tattacgaac tctggccttt atagcaggaa tttcctttat atttattttg
    15601 ttgggctatg gagctggttt tttaggcgat ttgctttatg cttcttggtt ccaatatctt
    15661 actggggcaa ttattatcct tcttggtttg caccaaatgg agattctaca ctttaagggg
    15721 ctttataagg aaaagaggct acaactgcaa ggacaggggc aaaatggtaa gggctatagt
    15781 caggcatttt tattgggctt gacctttagt tttgcttgga cgccttgcgt ggggccggtt
    15841 ctggggtctg ttttggcctt ggcggcttca ggtggttcag gagcttggca gggagctggt
    15901 ctcatgttgg tgtatacgct gggcttggcg ctaccattct tgcttctagc tctgacctct
    15961 agttatgttt tgaaacattt ccgaaaactt catccctatc tcggaatcct caaaaaagtg
    16021 ggtggttttc tcattattgt gatgggactc ttggttctgt ttggaaatgc ttcaatttta
    16081 agtcaattat ttgaataaaa tggaaaggaa tatcaatatg aaaaaatggc aaacatgtgt
    16141 tcttggagca ggttcgctcc tttggttgac ggcttgttca ggcaagtccg tgactagtga
    16201 acaccaaacg aaagatgaaa tgaagacgga gcagacagct agtaaaacaa gcgcagctaa
    16261 agggaaagag gtggctgatt ttgaattgat gggagtagat ggcaagacct accgtttatc
    16321 tgattacaag ggcaagaaag tctatctcaa attctgggct tcttggtgtt ctatctgtct
    16381 ggctagtctt ccagatacgg atgaaattgc taaagaagct ggtgatgact atgtggtctt
    16441 gacagtagtg tcaccaggac ataagggaga gcaatctgaa gcggacttta agaattggta
    16501 taagggattg gattataaaa atctcccagt cctagttgac ccatcaggca aacttttgga
    16561 aacttatggt gtccgttctt acccaaccca agcctttata gacaaagaag gcaagctggt
    16621 caaaacacat ccaggattca tggaaaaaga tgcaattttg caaactttga aggaattagc
    16681 ctaggaggtg tcttatgaat gataagttaa aaatcttctt gttgctagga gtattttttc
    16741 tagccataac cggtttctat gttctattga tacgaaatgc agggcagaca gatgcctcgc
    16801 aaattgaaaa ggcggcagtt agccaaggag gaaaagcagt gaaaaaaaca gaaattagta
    16861 aagacgcaga cttgcacgaa atttatctag ctggaggttg tttctgggga gtggaggaat
    16921 atttctcacg cgttcccggg gtgacggatg ccgtttcagg ctatgcaaat ggtagaggag
    16981 aaacaaccaa gtacgaattg attaaccaaa caggtcatgc agaaaccgtc catgtcacct
    17041 atgatgccaa gcaaatttct ctcaaggaaa tcctgcttca ctatttccgc attatcaatc
    17101 caaccagcaa aaataaacaa ggaaatgatg tggggaccca gtaccgtact ggtgtttatt
    17161 acacagatga caaggatttg gaagtgatta accaagtctt tgatgaggtg gctaagaaat
    17221 acgatcaacc tctagcagtt gaaaaggaaa acttgaagaa ttttgtggtg gctgaggatt
    17281 accatcaaga ctatctcaag aaaaatccaa atggctactg ccatatcaat gttaatcagg
    17341 cggcctatcc tgtcattgat gccagcaaat atccaaaacc aagtgatgag gaattgaaaa
    17401 agaccctgtc acctgaggag tatgcagtta cccaggaaaa tcaaacagaa cgagctttct
    17461 caaaccgtta ctgggataaa tttgaatccg gtatctatgt ggatatagca actggggaac
    17521 ctctcttttc atcaaaagac aaatttgagt ctggttgtgg ctggcctagt tttacccaac
    17581 ccatcagtcc agatgttgtc acctacaagg aagataagtc ctacaatatg acgcgtatgg
    17641 aagtgcggag ccgagtagga gattctcacc ttgggcatgt ctttacggat ggtccacagg
    17701 acaagggcgg cttacgttac tgtatcaata gcctctctat ccgctttatt cccaaagacc
    17761 aaatggaaga aaaaggctac gcttatttac tagattatgt tgattaatac tcttcgaaaa
    17821 tctcttcaaa ccacgtcagc gtcgccttac cgtatgtagg gttactgact tcgtcagttt
    17881 tatctacaac ctcaaagcgg tactttgaga aacctgtggc tatcttccta gtttactttt
    17941 tgatttttat tgagtataag aggtctttcc taagcagtta gaggagaatt ttgctatact
    18001 gatactagta agtggtaaag gagcagatca tgacctacac aatcttaatc gtagaagatg
    18061 aatatctggt aagacaaggt ttgactaaac tggtcaatgt agcagcctac gatatggaaa
    18121 tcatcggtca ggctgaaaat ggaaggcagg cttgggaatt gatccaaaag caggtgccag
    18181 atatcatttt aaccgatatc aacatgcctc atctaaatgg catccagttg gccagtctgg
    18241 tacgagaaac ctatcctcag gttcatttgg tctttttaac aggttacgat gattttgatt
    18301 atgccttgtc tgctgtcaaa ctaggtgtgg acgactacct gctcaaaccc ttttctcgtc
    18361 aggatattga ggaaatgttg gggaaaatca aacaaaaact agacaaggaa gagaaagaag
    18421 agcagttaca agatttattg actaataggt ttgaaggaaa catggcccag aaaatccagt
    18481 ctcatctggc tgatagccaa tttagtttaa agtctttagc cagtgactta ggttttagtc
    18541 cgacctatct gagttccttg attaagaaag agttgggctt gccttttcag gattatctgg
    18601 tgagagaacg tgttaaacaa gccaagctct tgcttttaac tacagatctg aagatttatg
    18661 agatcgcaga gaaggttggt tttgaagata tgaactattt tacccaacgt tttaagcaga
    18721 ttgcaggtgt gacacctcgt cagtttaaga agggagaaga ccgatgaagc gttcttctct
    18781 tttagttaga atggttattt ccatctttct ggtctttctc attctcctag ctctggttgg
    18841 aactttctac tatcaatcaa gttcttcagc cattgaggcc accattgagg gcaacagcca
    18901 aacgaccatc agccagacta gccactttat tcagtcttat atcaaaaaac tagaaaccac
    18961 ttcgaccggt ttgacccagc agacggatgt tctggcctat gctgagaatc ccagtcaaga
    19021 caaggtcgag ggaatccgag atttgttttt gaccatcttg aagtcagata aggacttgaa
    19081 aactgttgtg ctggtgacca aatctggtca ggtcatttct acagatgaca gtgtgcagat
    19141 gaaaacttcc tctgatatga tggctgagga ttggtaccaa aaggccattc atcagggagc
    19201 tatgcctgtt ttgactccag ctcgtaaatc agatagtcag tgggtcattt ctgtcactca
    19261 agaacttgtt gatgcaaagg gagccaatct tggtgtgctt cgtttggata tttcttatga
    19321 aactctggaa gcctatctca atcaactcca gttggggcag cagggctttg ccttcattat
    19381 caatgaaaac catgaatttg tctaccatcc tcaacacaca gtttatagtt cgtctagcaa
    19441 aatggaggct atgaaaccct acatcgatac aggtcagggt tatactcctg gtcacaaatc
    19501 ctacgtcagt caagagaaga ttgcaggaac tgattggacg gtacttggcg tgtcatcatt
    19561 ggaaaagtta gaccaggttc ggagtcagct cttgtggacc ttgcttgggg ccagtgtcac
    19621 atctcttctt gtctgtctct gcttagtgtg gttcagtctt aaacgctgga ttgctccttt
    19681 gaaggatttg agagaaacca tgttggaaat tgcttctggt gctcaaaatc ttcgtgccaa
    19741 ggaagttggt gcctatgaac tgagagaagt aactcgccaa tttaatgcca tgttggatca
    19801 gattgatcag ttgatggtag ctattcgtag ccaggaagaa acgacccgtc agtaccaact
    19861 tcaagccctt tcgagccaga ttaatccaca tttcctctat aacactttgg acaccatcat
    19921 ctggatggct gaatttcatg atagtcagcg agtggtgcag gtgaccaagt ccttggcaac
    19981 ctatttccgc ttggcgctca atcaaggcaa ggacttgatt tgtctctctg acgaaatcaa
    20041 tcatgtccgc cagtatctct ttatccagaa acaacgctat ggagataagc tggaatacga
    20101 aattaatgaa aatgttacct ttgataattt agtcttaccc aagctggtcc tacaacccct
    20161 tgtagaaaat gctctttacc atggcattaa ggaaaaggaa ggtcagggcc atattaaact
    20221 ttctgtccag aaacaggatt cgggattggt catccgtatt gaggatgatg gcgttggctt
    20281 ccaagatgct ggtgatagta gtcaaagtca actcaaacgt gggggagttg gtcttcaaaa
    20341 tgtcgatcaa cggctcaaac ttcattttgg agccaattac cagatgaaga ttgattctag
    20401 accccaaaaa gggacgaaag ttgaaatata tataaataga atagaaacta gctaactccc
    20461 agtcaattct gggagtttta tgcgtaattg ggcaaacttt ctaggttgtc tatcttgcta
    20521 aaaacaagaa aaaacggtat gatagaagag tgacaacaga ggtaacagag atgaacgaga
    20581 cacagattca aagagaaaca cgtcaggtag tggaagatgt tttagaaaag accaatttga
    20641 agcagggggc cctttttgtt ttaggtctat cttctagtga ggtgctaggt ggtcagattg
    20701 ggaaagaatc cagtcaagag attggtgagc tgatagtgga gactatcttg ggtattctaa
    20761 gtagtagagg tatccattta gcagttcaag gttgtgagca tgtcaatcgg gctctcgttg
    20821 ttgaacgtca ggtggcagag cagtttggtc tggaaattgt cagtgtccat cctactcttc
    20881 atgcaggagg ttcggggcag ttggcagcct ttaagtttat gcaggatcca gttgaggttg
    20941 aatttatcaa ggctcatgct ggattggata tcggagacac tgcaattggc atgcatgtca
    21001 agcatgttca ggttccgatt cgccctattt tgagagagat tggtcatgcc catgtaacgg
    21061 cactggctag tcgtccaaaa ttaatcggag gtgcgcgtgc gcactatccg caagacgcta
    21121 ttagaaagtc ttgagaatga ataaaggaga taaaagtgtt taaaaaagac cgtttttcaa
    21181 ttcgtaagat taagggagtt gtaggctctg tatttcttgg aagccttttg atggctcctt
    21241 ctgtagtgga cgcagccacc tatcactatg taaataaaga gattatttca caagaagcta
    21301 aagatttaat tcagacagga aagcctgaca ggaatgaagt tgtatatggt ttggtgtatc
    21361 aaaaagatca gttgcctcaa acagggacag aagcatctgt tttgacagct tttggtttgc
    21421 tgactgttgg gagcttgctt ttaatctaca agagaaagaa aattgctagc gtctttctag
    21481 ttggagctat gggattggta gttcttccta gtgcaggggc tgtagaccca gttgcgaccc
    21541 tagcgctggc tagtcgagag ggtgttgttg aaatggaggg ctatcgctat gttggttatc
    21601 tatcaggtga catcctcaaa acgcttggct tggacactgt tttagaagaa acctcagcaa
    21661 aacctggaga ggtgactgta gtcgaagttg agactcctca atcaataaca aatcaggagc
    21721 aagctaggac agaaaaccaa gtagtagaga cagaggaagc tccaaaagaa gaagcaccta
    21781 aaacagaaga aagtccaaag gaagaaccaa aatcggaggt aaaacctact gacgacaccc
    21841 ttcctaaagt agaagagggg aaagaagatt cagcagaacc agctccagtt gaagaagtag
    21901 gtggagaagt tgagtcaaaa ccagaggaaa aagtagcagt taagccagaa agtcaaccat
    21961 cagacaaacc agctgaggaa tcaaaagttg aaccaccagt agaacaagca aaagtcccag
    22021 aacaacccgt gcaacctaca caagctgagc aaccaagtac accaaaagaa acatcacaac
    22081 aagaaaatcc taaagaagat aggggagcgg aagagacacc gaaacaagaa gagtcaactc
    22141 cagataccaa ggctgaagaa actgtagaac caaaagagga gactaaaaca gctaagggga
    22201 cgcaagaaga agattacgtg ggtgaggctc ttgttccaga acaattacct gagtataagg
    22261 tgactgaagg aacactcgtt gaagaatcaa ctacagaact tgactataaa actgaaacga
    22321 ctgaggaccc aaccaagtac acggacgaag aaactgtcct acgaaatggt gaaaaaggaa
    22381 gtcaagttac aaaaacaacc tataaaacaa taggaggggt tgaaactgac caagttcttt
    22441 caaccagtac ggaagtcacc aaggagcctg taaatcaaca ggtaatccgt ggtacaaaac
    22501 caattgaagg gacaacggtt gagacaagag aagaaatcat tccttttgaa acaaaagaac
    22561 aagaagatga cactttaaaa cgcggaacaa gacaagtaac tcaagaaggt gtaaacgata
    22621 agaaacaaat tactgaaacc tataaaacaa ttcgcggaga aaaaacaagt gccgctccta
    22681 ctatcacaga aacagtgatt gaaaaacctc aagacaaaat tattaagaat ggcacaaaag
    22741 agttagagaa accaaccttg gaatgggcta aaacagataa agatgtcttg aagaagagtg
    22801 cgacagctag ttatacattg actaaaccag ctggagtaga aattaaatcg attaaagtag
    22861 ctctaaaaga taatactgga acagttgtta aagaagtaac ggtagaagaa aataacttac
    22921 aagctacttt agacaacttg aaatattatc aaggttatac actatccaca accatggtct
    22981 atgatcgagg taacggtgaa gaaactgaaa tattagaaga taaagaagtt cagttagacc
    23041 ttaaaaaagt tgagattaaa gatattaaag aaacaagatt gatgaaagtg gatgagaatg
    23101 gaaatgaaac agatagtagc cttctagaaa ctgttccaga aaatctaacg tcatattatc
    23161 taaaaattac cactaatcat aataaagtaa caaggcttgc cattactaat atagaggaag
    23221 taactgagga ggagacatcc ttatttaaag ttactgcttc agctcctgat ttaatccaac
    23281 gtgattcaaa taatagtttg agtcaaacat acacttatta catagagaaa cccaaagcat
    23341 cgcaaaataa cgtttactat aacttcaaag atttagtaga tgctatgcag aaaaatccta
    23401 acggtgagtt taaattagga tcggatttaa atgcaacaaa tgtacctaca ccaagtaaat
    23461 catatgtaac aggtaaattt acaggtcact taacaagtgt tgatggtaag catttctcca
    23521 ttcataacac tgctcgtcca ttatttgata gagttgaagg gggttctatc aaaaatatta
    23581 atttaattaa cgttaatatt aatatgcctt gggcaaatca attagcttca ttagctcaaa
    23641 cagtgaaaaa tgcaactgtt gaaaatatta aagtaacggg tactatcgtt ggtaataaca
    23701 atgttgcggg tattttggat aaattagatg atgcaggtat tatgactaat gttgctttta
    23761 tcggaaaagt tcaatctgtt ggtgataaag ggtggaactt ggctgggatt gcatctgaga
    23821 tttatcgagg caatttaaat aaagcttatg cagatgttga acttaaaggt ttaaatactc
    23881 gtgcaggtgc tatagtagga catttagctc atgattttaa tccaagagat gttggtgctt
    23941 ggtctaatgt aagaaattct gtagccaaag gtactattga tgttgctaga ggtgatgtag
    24001 gcggtttaat tggtaaagac tggccttggg gaaccattga taacaatatc agcttagtga
    24061 atgttaagcg tggtgatatt ttctttggtt ctaatgatat ggatgatgaa tttgtaagca
    24121 attggattaa acctaataat gcaacagtta tcggtgtgag ttctggagat aaaacccata
    24181 aacaatcgtc taaaattaaa gaaatttcac aggtagaagc tgataagaaa attaaggata
    24241 tgggtatcac tgctgataca tttgaagtaa ctgagcattt ggttgataag ttgaatcgcc
    24301 gtatattacg tgatgaagaa tacaaaacaa ttcaagatta taatgcaaat cgtgagcttg
    24361 tttatcgtaa tgttgaaaaa ctccaaccgt tctacaacaa agaatggatt gtgaatcaag
    24421 ggaacaagct tacaactgat agtccattaa tgaataaaga agtattgtct gtgactgcaa
    24481 tgaaaggtaa tgactttatt acagacctta cagatgctga ccatattatg gttcattacg
    24541 cagataagac aaaagatatc tttacgattt ctcctaaaga ctctcaagtt aagcaagtaa
    24601 aagaatacag tgtcgcagag cttggtgaag tcgtctatac accaaatatg gttgttaaag
    24661 atcgtgcaga tttaattagt gctattgaag gtattttaag tccaattgaa ttacaatctg
    24721 atccaattta tcaacgatta ggaagaactg gggataacag agttaatgca attaagaatc
    24781 tttacttaga agaaagcttt aaagaagtaa aagatcatct taatacattt gtgacaaaat
    24841 tagttgaaaa tgaagatcat caactgaata cagatgaagc tgcaaaacgt gccttgatta
    24901 agaaaattga agataacaaa gctgctgtcc tgttaggatt aacataccta aatcgttatt
    24961 acggtgtgaa atttgataac ttcaatatta aagaattaat gctattcaaa ccagattttt
    25021 atggtaagaa tgtaagtgtt ttagatcgat taatagaaat tggttcaaaa gaggactata
    25081 ttaagggaag tcgtacacag gagtccttcc gtgaagtggt ggcgaaaaat actctttctg
    25141 gaaacttaca tgacttcttg acctacaata tgaaactatt cacaaatgaa acagacataa
    25201 atgtttggtt taagaaagct attgaaaata atgcttatgt agttgaacaa ccgtcaacta
    25261 accctgcatt tgctaataaa aaatatcgtc tatatgaagg acttaataac ggacaacatg
    25321 gacgcatgat tttatcgctt ctgaacttga aagatgcaca tttatttatg atttcaacat
    25381 ataatactat ctcatttagt tcgtttgaaa agtatggtaa agatacagaa gaaaaacgtg
    25441 aagcgttcaa gagtgaaatc aataaacgtg ctaaagagca agttaattac ttagattttt
    25501 ggtcacgcct tgccactgat aatgtccgcg ataaacttct taagagtcaa aatgtagttc
    25561 caactcctgt atgggataat catggtgcac ccggtggttg gcctgataga tttggtcatc
    25621 gaaaagataa accggattat gcacctattc gtgaattctt tggacgtatt gataagtatc
    25681 atgattataa gtatgggtat ggagcgtatg cttacatctt tgctgatcca cagcctatgg
    25741 atgctgtata ttttgttatg tcggatttaa taagtgaata tggcacatct gcctttacac
    25801 atgagactac ccacgtaaat gaccgaatgg catatctggg aggtcataga catcgacagg
    25861 gtacagatct tgaagcattt gctcaaggta tgttacaaac tccagcagaa catggacatc
    25921 aaggtgaata tggcgcactt ggattaaata tggcatttga acgttcaaat gatggaaacc
    25981 aatggtataa tccagatcct accaaacttc aaacacgtga ccaaatcgac cattacatga
    26041 agaactacaa tgaagctatg atgatgctcg attatgcaga agctgaggct gttcttccta
    26101 aggttaaagg tgacaatagt aagtggttca agaaaattga tcgcgaaaca cgtcgaccaa
    26161 tggacagaaa taaactaagt ggtcctcacc aatgggacaa agtgcgtgat ttgatagacg
    26221 ctgagaaaac aactaacctt gaaaccatcg atgacttggt aaataataat ttcatgacca
    26281 ttcacggaaa tccaggtaat aaggtcttcc acccagagga ctttggtacg gcatatgtca
    26341 atgttaatat gatggctggt atttatggcg gtaatacgag tcaaggtgcc cctggttctc
    26401 tatccttcaa acataacgcc ttccgtatgt ggggttacta tggatatgaa catgggttca
    26461 ttgactatgt ttcaagcaaa catcaaggtg cagccaataa agaaaataac ggtctattag
    26521 gtgatgattt cattattaag aaagtttcta ataaccaatt ttcaaacctt gaagattgga
    26581 agaagcaatg gtatggggaa gttcttacaa aatctaaaaa aggttttgca ccaattgaaa
    26641 ttaatggcac tcaaatttca acctatgaac agttgaagac tatgtttgat gaggctgtta
    26701 ctaaagattt aacggaacta aacgatagta gtattaaaga caaataccga aatacagttg
    26761 tcttgaaatc gaaagtcttt aaatctctcc ttaaaaacac agacggtttc tctggtgatc
    26821 tatttactgc accacaagca tagaatgaat aaaatcgtaa aaaggtagat cagctttgtc
    26881 tgtatctgcc tttttatgct atacttaagg tatgcataga aaaacagtga ttgattttag
    26941 gactttaggg gagagatata cctttgccca gcctattaaa gagttgaaaa cgagaaatgt
    27001 agaagaagtg gcagatttgc tggcacaagt ggaaagctac caagagcaag gttattatgt
    27061 ggtggggtat gtcagctacg aggctgcacc tgcttttgag gaaaaattag cagttcacaa
    27121 ggatccccta ctgggagagt acctgcttta ctttactgtt catgatagcg tagaaacttc
    27181 ccctattcct ctgacttatg aggatattga tttgccctca aattggcagg aagtgacgtc
    27241 tgcagcagac tatgaaaagg ccattgccca gatacaccat cacttgaggc agggagacac
    27301 ctatcaggtc aactacaccg tccaactcaa gcaaaagtta agtgccaatc cttttgccat
    27361 ctacaatcgt atggtggtag agcaggaggc gggctacaat gcctatgtgg aacatgacga
    27421 gatggcagtg atttccatga gcccagagct cttttttgag caaaatgatc gcgagttgac
    27481 aacacgacca atgaagggga cgactcagcg tggggtaact gaccaagaag atcttgaaca
    27541 ggccagttgg ttggaacagg atcccaaaaa tcgctctgaa aatatgatga ttgtggacct
    27601 cttgcgcaat gatatgaacc gtatttctga agttgggagc gagcacgtgg agcgtctgtg
    27661 ccaggtagag cagtattcaa ctgtttggca gatgacttcg accatcaaga gtcagttgcg
    27721 agaggatgtg gaccttgttg aaatcttccg ctcactcttt ccttgtggtt ccataacggg
    27781 tgcaccgaaa attgcgacaa tggagattat caagaacttg gagcctcaac cgcgtggagt
    27841 ctactgtgga acgattggtc tcttgcttcc aaatggacga cggattttta atgtggccat
    27901 tcgtaccatt caacttcaca aaggtcaagc catttatgga gttggcggag ggattacttg
    27961 ggatagcaca tgggaatctg aataccgaga ggttcatcaa aaggcagcag ttctttatcg
    28021 taaacaagct cgcttccaac tgattacgac aggggaaatc agccagaaga acctgctgtt
    28081 tgaagatcaa catctggaaa gactgagaaa agctagtcgt tattttgcct ttccttttga
    28141 tgcagaagac ttgggacaca agattgagga agagtgtcag gattgtgaag ctaatcaaga
    28201 ttaccgcttg cgaatcagcc ttagcaaatc tggagagata gaagtcaatc gtcaagtatt
    28261 aacccctctc agtacaagct tttgtcaggc ccaagtctgc cttcaggaag ctgctttgaa
    28321 tcaatccttt acctacttta aaaccactca ccgaccgcat ttgagcctag gagaacaaga
    28381 gaagatttac cacaataagt caggagaact gcttgaaacc tctataggaa atttggttct
    28441 gaaaatcgct ggaaaactct acacaccgcc tatccgactt ggaatcttgc caggaattta
    28501 ccgtcagcat ttgctagaaa caggacaggt agaagagaaa gtcttgacct tggcagattt
    28561 aacccaagca gaagctattt acggctgtaa tgcagtgaga ggcttgtatg aactaagcct
    28621 tgaggagaac tagatgaaat tgatattttt gcatgggtta gagcagtcag cagagtcttg
    28681 gaaagaagtt cggaatctac tgacagatta tccttctgag gctatcgagt tatttccttc
    28741 tggagttagt aactatcaac aagctaaaga gcgagtttat cagcacctag ctcaagagac
    28801 agaacctttt gttttgattg gattgtcctt aggtgctgcc ctgacactag aactttccag
    28861 ttacgattta ccaaatcttc gagctttgat tctgtcagga tgcccgctta aattagcagg
    28921 gaatatccta ttttatcttc agttgctgat ttttaaacta cttcccaaaa gagtatttga
    28981 aaaacaggga gcagacaaga ctcttatggt cggagtttct gaggaattga agacacttga
    29041 tttaacggat atagcaggga cttgctccta tccaacctta ctaatttgtg gcagcaaaga
    29101 taaaccgaat cttagttcta tgaaagctct ccatagactg ttaacagatt cgcagtttca
    29161 gatcattcct gatggccctc atgtcttgaa taaggcaaaa ccaaaggagt ttgtagaaaa
    29221 gaccagaagt ttccttgaat tgctgaaata agtttgataa aataatattg aaatcgatat
    29281 cataattatg ggagaaagaa atgaataaac gtctattttt aaaaatgagt ctggtgacgt
    29341 tgccaatttt agccttgttt tcacaaccag ttttggcgga agaaaacatc catttttcga
    29401 gctgtaagga agcttgggcg aatggctatt cggatattca cgagggagaa cctggttatt
    29461 ctgccaagtt agaccgtgat catgatggtg tggcttgcga attgaaaaat gctcctaagg
    29521 gtgcttttaa agcaaaacag tcaacggcta ttcaaatcaa cacaagttca gcaacaacaa
    29581 gtggttgggt taagcaggac ggcgcttggt actactttga tggaaatgga aatctagtga
    29641 aaaatgcatg gcagggaagc tattacctga aagctgatgg taaaatggca cagagtgaat
    29701 ggatttatga ctcttcttat caagcttggt attatttgaa atcagatggt tcttatgcaa
    29761 aaaatgcatg gcaaggagct tattacctta aatcaaacgg taaaatggca caaggtgagt
    29821 gggtttatga ttcttcttac caagcatggt attacttgaa atcagatggt tcatatgctc
    29881 gcaatgcatg gcaaggaaac tactatttga aatcagatgg taaaatggct aaaggtgaat
    29941 gggtttatga tgccacctat caagcttggt attatttgac atcagatggt tcttatgctt
    30001 acagtacatg gcaaggaaat tactatctaa aatcgaatgg taaaatggct gtcaatgaat
    30061 gggttgatgg tggacgttat tatgttggcg ctgacggagt ttggaaggaa ggtcaagcaa
    30121 gtacagtttc ttctagtaat gatagcaata gtgaatattc tgctgcttta ggaaaggcaa
    30181 aaagttataa ttcgttattc cacatgtcaa aaaaacgtat gtatagacaa ttaacttctg
    30241 attttgataa attttcaaat gatgcagctc aatatgccat tgatcattta gatgattaac
    30301 agatactggt aggcgaaaaa attccttata attcatttac gcaaaccttt gcataagtga
    30361 atggattttg atatactagt actgtaagca ttttcaatta ctacacaatg aaaaaggaga
    30421 atatgatgag tcaaaagatt attgggattg accttggtgg aacttctatc aaatttgcaa
    30481 tcttaacaac agcaggagaa atccaaggaa aatggtcaat caagacaaac attttggatg
    30541 agggaagtca tatcgttgat gatatgattg agtctattca acatcgtttg gacttgcttg
    30601 gattggcagc agcggacttc caaggcattg gaatgggatc accaggtgtg gttgaccgtg
    30661 aaaaagggac tgttatcggt gcctacaact tgaactggaa aacccttcaa ccaatcaaac
    30721 aaaagattga aaaagctttg ggcattccat ttttcatcga taatgatgcc aacgtagcag
    30781 ctcttggtga gcgctggatg ggtgctggag ataaccaacc agacgttgtc tttatgacac
    30841 tcggtactgg tgttggtggc ggtatcgtcg cagaaggcaa attgcttcac ggtgttgctg
    30901 gtgcagcagg tgagcttggt cacatcactg ttgactttga ccagccaatc gcatgtactt
    30961 gcggtaagaa aggctgcctt gagacagttg cttcagcaac agggattgtc aacttgactc
    31021 gtcgctatgc cgatgaatac gaaggcgatg cagccttgaa acgcttgatt gataacggag
    31081 aagaagtaac tgctaagact gtctttgatc tcgcaaaaga aggagacgac cttgctttga
    31141 ttgtttaccg taacttctca cgttacttgg gaatcgcttg tgctaacatt ggttcaatcc
    31201 taaacccatc aacaatcgtc atcggtggtg gtgtgtcagc tgcgggagaa ttccttctac
    31261 aaggtgttca aaaagtttac gatgaaaata gtttcccaca agtacgcaca tctactaaat
    31321 tagctcttgc aactctagga aatgacgctg gagttatcgg agcagcatca cttgtattgc
    31381 aataagataa tgagagagga aaatgctaac ctagagttag taatgttcct cttttatttt
    31441 ttatgctata ctagttagga caatgaatga ggtgaaacga aatgacaaaa gcagatacga
    31501 tttttaaaga gaatattgaa cgcattctaa aggaaggtgt tttctcagag caggctcgtc
    31561 ctaagtacaa ggatgggact gttgctaatt ccaagtatgt aactggtgcc ttttccgagt
    31621 acgacttatc taaaggagaa tttcctatca caaccttgcg tcccattgca atcaaatccg
    31681 ccatcaaaga agttctctgg atttaccaag accagtcaaa tagcttagaa gtgcttaatg
    31741 acaagtacaa tgttcactac tggaatgact gggaagttgg agacacggga accattggtg
    31801 agcgctatgg tgccgttgtt aagaaacacg acattatcaa taagcttctc aaacagttgg
    31861 aaaccaatcc ttggaaccgc cgcaatatta tttcgctctg ggattaccaa gctttcgaag
    31921 aaacagatgg gctgctcccg tgcgcctttc agaccatgtt tgatgtccgg cgtgttgatg
    31981 gggaaatcta tctggatgcg accttgaccc agcgctccaa tgatatgctg gtggcccacc
    32041 acatcaacgc tatgcagtat gtggctttgc agatgatgat tgccaaacat tttggctgga
    32101 aggttgggaa gttcttctac ttcatcaaca acctccatat ctatgataat caatttgaac
    32161 aagctcagga attgctccgt cgggagccgt caaactgcca accacgcttg gttttaaatg
    32221 ttcctgatgg gactaatttc tttgatatca aagcagaaga ttttgagttg gtggattatg
    32281 accctgttaa gccacagttg aagtttgacc tagctattta aaagaataga aaaaagaagt
    32341 tgagaataat cccaacttct tttgtttctt aacgtgatac gcggcgacga gctgcttttt
    32401 tacggttttc ttcgatgaaa gctgcttttt gctcttctgg ttcgattact ttctttttaa
    32461 atgcgtatac tgcacctgca acggcagcga cagttcctgc gacacctgtt acaagacctt
    32521 tagcgaatcc tttagccatg agtcttcctc ctttatattc tcaatcagcc agcctcctca
    32581 agaggtcaca tttttctgac tgaccttttt gtgttataat aatagtaacg aaaaaatggg
    32641 aatttttcaa ggaaaaaaga tgaaaacaaa aataattgtg attgttggac cgactgctgt
    32701 tggaaagacg gctctagcta ttgaagttgc aaagcgtttt aatggcgaag tggttagtgg
    32761 agatagccag caagtctatc gaggacttga tattgggacg gccaaggcta gtccagaaga
    32821 gcaggcagct gttcctcatc atttaatcga tgttagagag ataaccgagt cttactcggc
    32881 ttttgatttt gtttcagaag ctaagatgac tattgagggt attcacaacc gtggcaagct
    32941 agccattatc gccggtggga ctggacttta tatccagagc ttgctagaag gttaccacct
    33001 aggtggggag actcctcatg aggagatttt agcttatcga gctagtttgg agccatattc
    33061 agatgaggaa ttagcccatt tggtggagca agcaggcctt gagattcccc agtttaatcg
    33121 tcgtcgtgct atgcgtgcct tagaaattgc ccattttggt caggatttgg aaaatcaaga
    33181 gattttgtat gaaccgctga ttatctgctt ggatgatgaa cgtagtcaac tttatgagcg
    33241 tatcaaccac cgagtggatt tgatgtttga ggctgggctt ttggatgagg ccaagtggct
    33301 gtttgaccat tcccctaatg tacaggctgc taaaggaatt ggctataagg aactctttcc
    33361 ttatttccgt ggagagcaga ccttggagga agctcgtgag agtcttaaac aggcgacccg
    33421 tcgttttgcc aagcgtcagc tgacctggtt ccgtaatcgc atgcaggtca ccttttatca
    33481 gattggagaa tctggtgtac aagaccgcat tttaagccag atagaggagt ttttagatga
    33541 ttgaaacgga gaaaaaagag gagcgagtcc tgctgattgg tgtggaattg cagggtatgg
    33601 acagttttga cctctccatg gaagaattgg ctagtttagc gaaaacggca ggggcagtcg
    33661 ttgtagatag ctacagacaa aaacgtgaaa aatatgattc caagaccttc gtcggctctg
    33721 gtaagttgga agagattgcg cttatggtgg atgcagaaga aatcactact gtcatcgtca
    33781 acaaccgtct gaccccaagg cagaatgtca atctagagga agttctcggt gttaaggtca
    33841 ttgaccgtat gcagttgatt ttggatatct ttgccatgcg ggctcgaagc catgaaggga
    33901 agctccaagt ccacctagcc caactcaaat acctcttgcc tcgcttggtt ggtcagggga
    33961 ttatgctcag ccgtcaggca gggggaattg gttcccgtgg tcctggtgaa agccaactgg
    34021 agctgaaccg tcgtagcgtt cgcaatcaaa tcacggatat cgagcgccag cttaaggtgg
    34081 ttgagaaaaa tcgtgcgact gtcagagaaa aacgtttgga gtctagcact tttaagattg
    34141 gtttgattgg ttatactaat gctgggaaat caactatcat gaacatcttg accagtaaga
    34201 cccagtatga agcagatgag ctctttgcga ctctggatgc gacaaccaag agtattcatc
    34261 tgggaggcaa cctccaagta actttgacag ataccgttgg ctttatccaa gatttgccga
    34321 cagagttggt gtccagtttc aagtcaacct tggaagaaag caagcatgtg gaccttctgg
    34381 ttcatgttat cgatgctagc aatccttacc acgaggaaca tgaaaaaacg gttctctcca
    34441 tcatgaaaga cctggacatg gaagatattc ctcacttgac gctttataat aaagcggatt
    34501 tggtggagga tttcatgcct acccaaacgc catataccct catttctgcc aagtctgagg
    34561 acagtcgtga aaacttgcaa gcattattgc tagataagat taaggaaatt tttgaagcat
    34621 ttaccctgcg agtgcctttt tcaaagtcct acaagattca tgatttagag agtgttgcaa
    34681 ttctggaaga acgtgattat caggaagacg gcgaagtgat tacaggctac atttccgaga
    34741 aaaataaatg gaggttagaa gaattttatg actgatatta aaactttggc tctaaagtat
    34801 ggaggttata caagtctgga caaggtctat ctggatcagc ttctagctgg taagacagag
    34861 caggagcagt taacacttat tacacctccg ccaagtgttg ttaatgccta ctttgcagaa
    34921 ctctatcaga aaaaaagtcc tcaggctgcg acggattatt ttgcagaact cagtcaggaa
    34981 ctgaatcttt acaatactga gccaagtttc accctagaaa ataagtcttt tattcggctt
    35041 aatctgtctg gtaaatcctt tggtttttgt tatgagagtg acggctttgg tcggattttc
    35101 tctgaaaatg aggagaaaat ctcggatgac ttgctctttg aaattgcgca aattttcccc
    35161 catcaattag tctttgaaga gtctggtaag atttacatga agcctgtcga ggacgaggaa
    35221 gttgtcagcc tagaaagtct cacagctttg actgatttgg aaagattggc tgatggtcga
    35281 aaacgtctca aaggctacag ccaagaggat ttattgcaag aagctgctgc tttttctggc
    35341 aaacgctatt tccgatcgga aaaccgcaca gccatgttat atattgatta attagaaagt
    35401 atcgaatgga tattcaattt ttaggaacgg gggctggtca gccctctaaa gcccgcaacg
    35461 tttcaagtct cgccctgaaa cttttggacg agattaacga agtttggctc tttgactgtg
    35521 gagaaggtac gcaaaatcgc attctggaaa ccacaattcg accacgtaag gtcagcaaaa
    35581 tctttattac tcatctgcat ggagaccaca tttttggttt gccaggtttc ctttctagcc
    35641 gtgcctttca ggccaatgaa gagcagacag atttggaaat ctacggacct caaggaatca
    35701 agtcatttgt cttaaccagc cttcgtgtgt caggttctcg tctgccctac cgcattcatt
    35761 tccatgagtt tgaccaagat tctctgggta aaattctcga aaccgataaa ttcactgtgt
    35821 atgcagagga gctggaccac actattttct gtgttggcta tcgtgtcatg caaaaggatc
    35881 tagaagggac gctggatgct gaaaaactca aggctgctgg tgttccgttc ggcccgcttt
    35941 ttggtaaaat caaaaacggc caggatcttg ttttggaaga cggaactgaa atcaaggcag
    36001 cagactatat ctcagcgcca cgtccaggta agattatcac tattttagga gacactcgaa
    36061 aaacggatgc cagtgtgcgt ctggctgtca atgcagatgt cctagttcat gagtccactt
    36121 atggcaaggg tgatgaaaaa attgctcgta accatggtca ctcaactaat atgcaagctg
    36181 cacaagtagc ggtagaagca ggtgccaaac gcctcctact caaccatatc agtgcccgtt
    36241 tcctctcaaa agatataagc aaactcaaga aggacgctgc cacaattttt gaaaatgtcc
    36301 atgtggtcaa agacttggaa gaagtggaaa tctagcagtc acagaaagga taagtatgcc
    36361 tactattctc attaccggag ctagcggtgg tctagctcaa gaaatggtca aactcctgcc
    36421 caatgaccaa ctcatcttgc ttggtagaaa taaggaaaaa ttagcccaac tctacggaaa
    36481 ttattcccat gcagaattga ttgaaattga tattaccgac gattcagccc tagaagctct
    36541 ggtaactgat ctttatctcc gctatggcaa gattgatgtc ttgattaaca acgctggtta
    36601 cgggattttt gagggatttg accaaattgc tgataaagac attcaccaga tgtttgaggt
    36661 caataccttt gccctgatga atctgtctcg tcaccttgcg gctcgtatga aggaaagcag
    36721 caaagggcat atcatcaaca tcgtcagcat ggcaggtcta atagctactg gcaagtctag
    36781 tctttactca gcgaccaagt ttgcggctat tggtttttca aatgctctgc gactcgaact
    36841 tatgccctat ggagtctatg tgacaacagt caatccaggt ccaatccgaa caggattttt
    36901 tgaccaagct gacccagatg gaacttatct taaatcggtt gaccgcttcc tctcagaggc
    36961 agatgcagtg gctaaaaaga ttgtcaagat tataggaaaa aataaacgag aactcaatct
    37021 cccgattttg ttgaacctag cccataagtt ttatactctc tttcccaagc tagctgataa
    37081 gttggcaggg gaaactttta attataagta aaaagaacca atgtgcaggt tgttgctagc
    37141 ctacatattg gttcttatca tttctcaact atcaaactga acttcttcta gtagatagtc
    37201 gataaagcgt tcgcccatct tagataggct ggttttctca tgctggatat agaccagctc
    37261 aatcgggtca tcaatatcca gtgggataga aacgatattg tctccgttta ggttgctgtt
    37321 caaaatccct gtcgcaatgg tataaccatc caaaccaatc aagagattaa agagggtggc
    37381 acggtcactg accacaatgg atttcttgtg gtgttcttga gaaagaatct cttctgaaaa
    37441 gtagaaggag ttgtgcgtcc cttggtcata gctgaggtaa gggaaattct ccaaatcaga
    37501 cagtttcacc ttgtctttct ttgccagagg gttggtcttg ctgacaaaga tatgcggttg
    37561 cgctgtgaag agatggtggg atagcaggtg attgtcatcc agcatcttgg ttaaaacatc
    37621 acggttgtaa ctgtttaaga agaggacccc gacctcactg cggaagttct tgacgtcgtc
    37681 gataatctcc caagtccgag tttcacgaag gaagagttcg tatttctcca tatcgctttt
    37741 cttgagcaaa gagacaaagg cattgaccac aaaggcatag tgttgagacg aaacgctaaa
    37801 gagttcgcgg tgggcaacag gatttttata gcgttcctcc agaagctggg tctgctcgac
    37861 aacctgacgg gcataagaga gaaactccat cccatcacgg gtcaaggtaa tacccttggg
    37921 attgcggata aagatttcaa tgcccatttc attttccaaa tctcgcactg cattggagag
    37981 actgggctga gtgataaaga gttgcttggc tgcctcattc atagagccag tttcgacgat
    38041 tttgataata taatgtaatt gttgaattct catgttttta ttgtaccaca cttgccttag
    38101 aatcgccaaa gaagatagga aaataaggag cattgtgtga gtctcttctt gaaaaaaaca
    38161 caaaattttg ctagaatgag tcttatgaaa acattctatg atgtgcagca attcctcaaa
    38221 cgatttggta ttattgttta catgggaaaa cgcttatatg atattgaact gatgaagttg
    38281 gaactatctc ggatttacga tgcagggttg atggataaat tagactatct agaggcagaa
    38341 gcagttcttc gcagagagca caaggtagaa ttggattata ttgagaaaaa tggagaaaag
    38401 aactaatggt tacttggatt ttgtgggcac ttatactagc aatgttggcg tggatgggct
    38461 ttaactatct tcgtattcgt cgtgcggcta aaattgtgga caatgaggag tttgaagcct
    38521 tgattcgtac gggtcaattg attgatttgc gcgacccagc agaattccac agaaaacata
    38581 tccttggtgc acgcaatatt ccttcaagtc agttgaaaac tagtcttgca gcccttcgta
    38641 aagataaacc tgtccttctc tacgagaacc aacgtgcgca acgagttaca aatgcagctc
    38701 tttacttgaa aaaacaaggt ttttctgaga tttatatcct ttcttatggc ttggattctt
    38761 ggaaagggaa agtgaagact agctaacctt atttccaaat tagtcgaatg ataggatgaa
    38821 gctattgttt tatagtataa ttaatttgta taaaatttaa agagttctta gaacatgaaa
    38881 gaaaagaaga aaaatccact ttttgtgggt atcttgtcga ttattcttgg tttgttattt
    38941 ccaattgtag gcctgatttt gggtatcata ggattggtct tggctatttc ataccaaaaa
    39001 gagtcacaat tagactataa aatagaaaag attcttaata tcttaggaat tgtgatttct
    39061 gtagttaact ggattgtagc aatcgcctta atttttcggt aaataaaaga aaaaagcttt
    39121 agttttaaag ctttttttgt tttatcgact catctctaaa tagtttttaa tgatttgtaa
    39181 ctctttttgg ttcaaagggc ggtagttact ttctgctaaa tctgggttca atgtgaagtc
    39241 cccaaattgg attcttttga ggctagtcac cttaacacca accgagagga acattttctt
    39301 gatttgatga aattttcctt ctgaaatggt gatagaggct tgactgaggg agggacttgc
    39361 agatagaatc tctagttttg cgggtttaca gacagtacca tctaaaaaga caattccctt
    39421 ttgaaaggct tggatatggt caggtgttag aagtccatta acctggactt ggtaagtctt
    39481 atcgacatga tattggggat ggaggagctg aaagcccaag ggaccgttat cggtcaagag
    39541 gaggagtccc gttgtatctc ggtccagtcg gccaacggca tagagcttgt cagactggat
    39601 gtcagatgga agcaggtcca tgacggtcgg aagttccttg tctttgttgg ctgtaacgac
    39661 accagcaggc ttatgaagca taagataggt gtgttcatag ccttgaatga ttcgatcctg
    39721 aaaaaggagt tcttgtagtc ctgtatcgat attttgggct agggatcggg ctgggcaact
    39781 atcgacgaga atgtcccctt tgagtaaggc ttgtttcatg gcctttcggc tgattttttc
    39841 ttgagctaat aaattatcta aacgcatact gtgcctatct tatcataagt cgcttgcttt
    39901 gaaaaggctt gacgtgaaaa gaaaagcgga gtgaaaacat ttacacttgc ttgagttatg
    39961 ttatttattt gaaattatgg tataatcgtt cagttagaaa ataaattttg aatattatag
    40021 aggaaatcat gacaaaatta agagaagata tccgtaacat tgcgattatc gcccacgttg
    40081 accacggtaa aacaaccctg gttgacgaat tattgaaaca atcagaaacg cttgatgcac
    40141 gtactgaatt ggcagagcgt gctatggact caaacgatat cgaaaaagag cgtgggatta
    40201 ccatccttgc taaaaatact gccgttgctt acaacggaac tcgtatcaac attatggaca
    40261 caccaggaca cgcggacttc ggtggagaag ttgagcgtat catgaaaatg gttgacggtg
    40321 ttgtcttggt cgtagatgcc tatgaaggaa ccatgccaca aactcgtttc gtattgaaaa
    40381 aagccttgga acaagacctt gtcccaatcg tggttgttaa caaaatcgat aagccatcag
    40441 ctcgtccagc agaagtagtg gatgaagtct tggaactttt catcgagctt ggtgcagatg
    40501 acgaccagct tgatttccca gtggtttatg cttcagcgat caacggaact tcttcattgt
    40561 cagatgatcc agctgaccaa gaagcgacta tggcaccaat ctttgacacg attatcgacc
    40621 atatcccagc tccagtagat aactcagatg agcctttgca gttccaagtg tcacttttgg
    40681 actacaatga cttcgttgga cgtatcggta tcggtcgtgt cttccgtggt acagttaagg
    40741 ttggggacca agttaccctt tctaaacttg acggtacaac taaaaacttc cgtgttacaa
    40801 aactcttcgg tttctttggt ttggaacgtc gtgaaatcca agaagccaaa gcgggtgact
    40861 tgattgccgt ttcaggtatg gaagacatct ttgtcggtga aaccatcact ccgacagatg
    40921 cagtagaagc tcttccaatc ctacacatcg atgagccaac tcttcaaatg actttcttgg
    40981 tcaacaactc accatttgct ggtaaagaag gtaaatgggt aacttctcgt aaggtggaag
    41041 aacgcttgca ggcagaattg caaacagacg tttcccttcg tgttgaccca actgattcac
    41101 cagataaatg gactgtttca ggacgtggag aattgcactt gtcaatcctt atcgaaacaa
    41161 tgcgtcgtga gggctatgaa cttcaagtat ctcgtccaga agttatcgta aaagaaatcg
    41221 acggtgttaa atgtgaacca tttgaacgtg tacaaatcga cactccagaa gaataccaag
    41281 ggtctgttat ccaaagcctt tctgaacgta aaggtgaaat gttggatatg atttcaactg
    41341 gtaatggtca aactcgtttg gtcttccttg ttccagcgcg tggtttgatt ggatactcaa
    41401 ctgagttctt gtcaatgact cgtggttacg gtatcatgaa ccataccttc gaccaatact
    41461 tgccattgat tccaggggaa attggtggac gtcaccgtgg tgcccttgtt tctatcgatg
    41521 ctggtaaggc tacaacttac tcaatcatgt ctatcgaaga acgtggtacg atctttgtca
    41581 acccaggtac tgaggtttat gaaggaatga tcatcggtga aaactctcgt gaaaatgact
    41641 tgacagttaa catcacgaag gcaaaacaaa tgaccaacgt tcgttcagct actaaggacc
    41701 aaacagctgt tatcaagacg cctcgtatct tgacacttga agagtctctt gagttcttga
    41761 acgacgatga gtacatggaa gtaacgcctg agtctatccg tttgcgtaaa caaatcctta
    41821 acaaagcaga gcgtgagaaa gctaacaaga agaaaaaatc agctgaataa gagctagaaa
    41881 gagagaaaga tggtctattt agtcctagga attttactgc tcctactcta tgtatttgcg
    41941 acaccagaaa gcattaaagg gacagtcaat atcgtcgcta tggtatgtat tttagtggca
    42001 ctcttgattt tattggttct atcttttctg aaaatttttc aattaccaac agaaatattc
    42061 ctagcaatag ccatgttgat cctagcttac tttagtgtta gagacatcac actcatgcca
    42121 gtcaaaaaaa gtaaaagaag ataaaaaaga gagtttcggc tctctttttg ctaggaattt
    42181 tataatagtt tgaattgctt tttagttaac accatctctt ttgcttgtat agtatgaatg
    42241 ggaaaaactt gaataaaatt cgttaatggc atctattt
//
LOCUS       DAVHSO010000011        40426 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.011, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000011 DAVHSO010000000
VERSION     DAVHSO010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 40426)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40426)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40426
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.011"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(95..1261)
                     /gene="recA"
                     /locus_tag="VVR18_000560"
     CDS             complement(95..1261)
                     /gene="recA"
                     /locus_tag="VVR18_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HEU6032137.1"
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGE
                     RAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGI
                     AAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
                     ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGN
                     PETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAV
                     VEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFD
                     EIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVTLDLGDELEIEIEE"
     gene            complement(1316..2572)
                     /locus_tag="VVR18_000561"
     CDS             complement(1316..2572)
                     /locus_tag="VVR18_000561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HEU6032138.1"
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGD
                     NEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIF
                     FALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
                     VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLR
                     LSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQG
                     KTIAAAESLTAGLFQATVANFSGASSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVS
                     EFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIG
                     GRSRADVRHIAVMHAFNLVRKALLSD"
     gene            complement(2657..3673)
                     /locus_tag="VVR18_000562"
     CDS             complement(2657..3673)
                     /locus_tag="VVR18_000562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HEU6032139.1"
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGE
                     ETKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDIL
                     TRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVG
                     GITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQ
                     REVIQKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQ
                     QLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVG
                     DEDN"
     gene            complement(3681..4199)
                     /locus_tag="VVR18_000563"
     CDS             complement(3681..4199)
                     /locus_tag="VVR18_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032140.1"
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSE
                     EMEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNG
                     LGSLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGK
                     FIDVYLMGKLIG"
     gene            complement(4189..4632)
                     /gene="tsaE"
                     /locus_tag="VVR18_000564"
     CDS             complement(4189..4632)
                     /gene="tsaE"
                     /locus_tag="VVR18_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HEU6032141.1"
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLA
                     KGLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWG
                     NLLGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            complement(4719..5339)
                     /locus_tag="VVR18_000565"
     CDS             complement(4719..5339)
                     /locus_tag="VVR18_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032142.1"
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFV
                     SGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQ
                     ELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
                     VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            complement(5722..6585)
                     /locus_tag="VVR18_000566"
     CDS             complement(5722..6585)
                     /locus_tag="VVR18_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032143.1"
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSA
                     DLLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYDDLEYIYRIEIERS
                     TFLTLEDRTYLEWIKAIIDLYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFY
                     SLVGREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEA
                     LETIELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMK
                     IENYLKELDAV"
     gene            7089..9104
                     /locus_tag="VVR18_000567"
     CDS             7089..9104
                     /locus_tag="VVR18_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU6032144.1"
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSYYYPNVVVHDSSPE
                     TTFQHVATRLEKLAEETDSFIAIQHQDSNSEGTTVFSYTTFGDGKLPDGLQEKNLEDA
                     QSSSVETNYFVFDGHLDIHLLREELSQLGLTNMHLTIPSKLSTLMAIFSNGFQLISLL
                     IFILTFVALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKAIAVGFSLAGVLAI
                     LMQKILSLPTQSLMTIGAGLLSYNLILLSISLFFAQLFAVGIKKIHLMQIIKGQVPVR
                     GIISLILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSISREGTS
                     PGFDEQAQRKLRTWYQLMDLAVSEQKAFLSRHQLIDRTLQNGMASSKNLITSTEWHDY
                     NPNGNVLIVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFED
                     DLTSRMSSQDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQ
                     SILFWIDAVQNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVM
                     LAGAVLGIATSILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLG
                     FVASVFLQVEIGVAFLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            9106..9738
                     /locus_tag="VVR18_000568"
     CDS             9106..9738
                     /locus_tag="VVR18_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032145.1"
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLM
                     NMIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIG
                     QKLSRSEQRLRQKQALEQVGLAYLDLDKRIFELSGGESQRVALAKIILKNPPFILADE
                     PTASIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            9879..10157
                     /locus_tag="VVR18_000569"
     CDS             9879..10157
                     /locus_tag="VVR18_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComA"
                     /protein_id="HEU6032146.1"
                     /translation="MKKFDNYIIEKPCDSNSDKLQKILIIENLVDDILQFPLRINNSV
                     GEIFLLQPFQKKTIFIPCYFEEDIVKVKDDDKVEWNLLEFQKFRAFLA"
     gene            complement(10666..11079)
                     /gene="ndk"
                     /locus_tag="VVR18_000570"
     CDS             complement(10666..11079)
                     /gene="ndk"
                     /locus_tag="VVR18_000570"
                     /EC_number="2.7.4.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="HEU6032147.1"
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEE
                     LIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTI
                     RGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF"
     gene            complement(11190..14867)
                     /gene="rpoC"
                     /locus_tag="VVR18_000571"
     CDS             complement(11190..14867)
                     /gene="rpoC"
                     /locus_tag="VVR18_000571"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HEU6032148.1"
                     /translation="MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPERE
                     GLFDEVIFGPTKDWECACGKYKRIRYRGIVCDRCGVEVTRTKVRRERMGHIELKAPVS
                     HIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLR
                     EYGYGSFVAKMGAEAIQDLLKQVDLEKEIAELKEELKTATGQKRVKAIRRLDVLDAFY
                     KSGNKPEWMILNILPVIPPDLRPMLQLDGGRFASSDLNDLYRRVINRNNRLARLLELN
                     APGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLG
                     KRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDIVQNVKAAKRLVE
                     RGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNAD
                     FDGDQMAIHVPLSEEAQAEARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEA
                     GREGEGMVFKDRDEAVMAYRNGYVHLHSRVGIATDSLNKPWTEEQRHKVLLTTVGKIL
                     FNDIMPEGLPYLQEPNNANLTEGVPAKYFLPLGGDIKEAISNLELNPPFKKKNLGNII
                     AEIFKRFRTTETSALLDRMKNLGYHHSTLAGLTVGIADIPVVDDKAEIIEESHKRVEQ
                     ITKQFRRGMITDDERYNAVTAEWRAAREKLEKRLIANQDPKNPIVMMMDSGARGNISN
                     FSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSG
                     YLTRRLVDVAQDVIIREDDCGTDRGLLIRSIAEGKEMIESLEERLNGRYTKKTVKHPE
                     TGAVIIGPNELITEDKAREIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVE
                     VGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVI
                     TEVKGQVTAIEEDASTRTKKVFVKGETGEGEYVVPFTARMRVEVGGQVARGAALTEGS
                     IQPKRLLAVRDVLSVETYLLGEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDT
                     DLLMGTLMDINDFTDANKDVLIAGGVPATGRPVLMGITKASLETNSFLSAASFQETTR
                     VLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPYAVNEEEYLNPPVEEEG
                     NEETTEVVVDTAVETVEETVE"
     gene            complement(14900..18511)
                     /gene="rpoB"
                     /locus_tag="VVR18_000572"
     CDS             complement(14900..18511)
                     /gene="rpoB"
                     /locus_tag="VVR18_000572"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEU6032149.1"
                     /translation="MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHG
                     LKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKE
                     TGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGS
                     TVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVR
                     NTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVG
                     RYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKI
                     VYIPNDAAVVTEPVVLQKFKVVAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYF
                     LNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQ
                     QIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVR
                     DVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIV
                     WLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVA
                     VATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQY
                     DGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIAD
                     GPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDT
                     KLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERL
                     LHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRK
                     IKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHL
                     GMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGV
                     MYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVL
                     QEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQ
                     EVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE"
     gene            18927..18997
                     /locus_tag="VVR18_000573"
     tRNA            18927..18997
                     /locus_tag="VVR18_000573"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:18959..18961,aa:Cys,seq:gca)
     gene            complement(19195..20526)
                     /locus_tag="VVR18_000574"
     CDS             complement(19195..20526)
                     /locus_tag="VVR18_000574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HEU6032150.1"
                     /translation="MEDPSSQNLLLQFVLLFILTVLNAFFSATEMAMVSLNRARVEQK
                     AEEGDRRYIRLLKVLENPNHFLSTIQVGITLITILSGASLTNTLGRVIASWLGNGETA
                     QAVATFLSLAFLTYISIVFGELYPKRIALNLKDALAIRTAPVIIGIGKLVSPFVWLLA
                     ASTNFLSHLTPMSFDDADEKMTRDEIAYMLTNSEETLDADEIEMLQGVFSLDELMARE
                     VMVPRTDAFMVDIQDDSQAIIQSILKQNYSRIPVYDGDKDNVIGIIHTKSLLKAGFVD
                     GFDNIVWKRILQDPLFVPETIFVDDLLKELRNTQRQMAILLDEYGGMAGLVTLEDLLE
                     EIVGEIDDETDKAAIDVHQIGEDTYIVQGTMTLNDFNNYFDVELESDDVDTIAGYYLT
                     GVGTIPTTEKLSYELVSQNKQFILTNDKVKNGRVTKVKVQITEVEIEEETE"
     gene            complement(20755..21579)
                     /gene="endA"
                     /locus_tag="VVR18_000575"
     CDS             complement(20755..21579)
                     /gene="endA"
                     /locus_tag="VVR18_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-entry nuclease EndA"
                     /protein_id="HEU6032151.1"
                     /translation="MNKKTRQTLIGLLVLLLLSTGSYYIKQMPSAPNSPKTNLSQKKQ
                     ASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTK
                     TVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
                     LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRV
                     RYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ"
     gene            complement(21618..21806)
                     /locus_tag="VVR18_000576"
     CDS             complement(21618..21806)
                     /locus_tag="VVR18_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEU6032152.1"
                     /translation="MNKKSSYVINRLLLVIIVLILGTLALGIGLMVGYGILGKGQDPW
                     AILSPAKWQELIHKFTGN"
     gene            complement(21799..23082)
                     /gene="murA"
                     /locus_tag="VVR18_000577"
     CDS             complement(21799..23082)
                     /gene="murA"
                     /locus_tag="VVR18_000577"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEU6032153.1"
                     /translation="MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQ
                     NVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVL
                     GPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
                     YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETIT
                     ITGVEKLHGTTHNVVQDRIEAGTFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVE
                     VIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFEN
                     RFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETV
                     VGKLVHLDRGYYGFHEKLAQLGAKIQRIEASDEDE"
     gene            complement(23106..23336)
                     /locus_tag="VVR18_000578"
     CDS             complement(23106..23336)
                     /locus_tag="VVR18_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014017351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1146 domain-containing protein"
                     /protein_id="HEU6032154.1"
                     /translation="MVQLLFTLSSHMLFIYVSFYLLKDLVRWEKVLKVTDDNTRKVRL
                     LVAFFSIVIGYILSSFFISLYHLWQEALRGLL"
     gene            complement(23394..24431)
                     /locus_tag="VVR18_000579"
     CDS             complement(23394..24431)
                     /locus_tag="VVR18_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PDZ domain-containing protein"
                     /protein_id="HEU6032155.1"
                     /translation="MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLK
                     VNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFTDIRSAQETTGGSSDVEFLRINQ
                     FYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
                     DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVIS
                     NVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGID
                     KKVVASARAGAAIFFTPDNPVSEEEQKAHPDAKNNYQTALEAAKTIKTDMKIVPVKTL
                     QDAIDYLKNNP"
     gene            complement(24415..24903)
                     /gene="coaD"
                     /locus_tag="VVR18_000580"
     CDS             complement(24415..24903)
                     /gene="coaD"
                     /locus_tag="VVR18_000580"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HEU6032156.1"
                     /translation="MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQ
                     GFLPLENRKRGLEKAVKHLGNVKVVSSHDKLVVDVAKRLGATCLVRGLRNASDLQYEA
                     SFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEK
                     KD"
     gene            complement(24893..25432)
                     /gene="rsmD"
                     /locus_tag="VVR18_000581"
     CDS             complement(24893..25432)
                     /gene="rsmD"
                     /locus_tag="VVR18_000581"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HEU6032157.1"
                     /translation="MKIISGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEGGR
                     VLDLYAGSGGLSIEAVSRGMSSAVLVERDRKAQTIVAENIQMTKEVGKFQLLKMDAER
                     ALEQVSGEFDLIFLDPPYAKEQIVADIEKMAERELFSEDVMVVCETDKAVELPEEIAC
                     LGIWKEKIYGISKVTVYVR"
     gene            complement(25497..26489)
                     /locus_tag="VVR18_000582"
     CDS             complement(25497..26489)
                     /locus_tag="VVR18_000582"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HEU6032158.1"
                     /translation="MKKSFIHQQEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGM
                     QDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRHTLARFGFGEGEGLFVHMKALRPD
                     EDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYDIESI
                     LPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDY
                     DDWTSESENGYKGLNGDILVWNESLGGAFELSSMGIRVDEETLRRQVEITGDEDRLEL
                     EWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSVWPQEVRDTYENIL"
     gene            complement(26601..27284)
                     /locus_tag="VVR18_000583"
     CDS             complement(26601..27284)
                     /locus_tag="VVR18_000583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="HEU6032159.1"
                     /translation="MNHTIIHDRAGLNQFYAKVYAFVGLGIGLSALVSGLMLTVFQSQ
                     LVYLLMQGRLWLTIATFAELALVFVASSMASRNSPAALPVFLLYSVLNGFTLSFVVAF
                     YTPGTVLSAFVSSALLFFVMAAVGIFTKKDLSGIGRAMMAALIGLLIAMVVNIFLASG
                     FFDYMISVAMVLVFSGLIAWDNQKIRLAYEQSQGRVATGWVVSMALSIYLDFINLFLS
                     ILRIFGRND"
     gene            complement(27340..28080)
                     /locus_tag="VVR18_000584"
     CDS             complement(27340..28080)
                     /locus_tag="VVR18_000584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HEU6032160.1"
                     /translation="MTIITSKANSVVKNAKKLHQKKYRKSAYLIEGWHLFEEAVQAGV
                     TIEKIFALENYRNQLAAFPQTVWISEDILLDLADSQTPQGIVAVVQKEEVGQADLSQG
                     KFLFLEDVQDPGNVGTIIRTADAAGFTGVIVSDKSADIYSLKTLRSMQGSHFHLPIYR
                     MTSQALLDETKKVAIPVLATTLSKDSVDYRELPSIENFVLVMGNEGQGISPLMAESAD
                     QLVHISMKGQAESLNVAVAAGILIFHLS"
     gene            28114..28392
                     /locus_tag="VVR18_000585"
     CDS             28114..28392
                     /locus_tag="VVR18_000585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001174612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acylphosphatase"
                     /protein_id="HEU6032161.1"
                     /translation="MQKVRMIAQGRVQGVGFRWGVYSLALEIGGITGRVWNNDDGTVE
                     ILAQADSSAIMAKFIQEIRKGPTPFSKVSYLDVKLSNFPPYSDFKIAN"
     gene            28470..29396
                     /gene="yidC"
                     /locus_tag="VVR18_000586"
     CDS             28470..29396
                     /gene="yidC"
                     /locus_tag="VVR18_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEU6032162.1"
                     /translation="MKSIKRFALSAMGVAMLLVLTGCVNVDKTTGQPTGFIWNTIGAP
                     MAEAIKYFATDKGLGFGVAIIIVTIIVRLIILPLGIYQSWKATLHSEKMNALKHVLEP
                     HQTRLKEATTQEEKLEAQQALFAAQKEHGISMFGGVGCFPILLQMPFFSAIYFAAQHT
                     EGVAQASYLGIPLGSPSMILVACAGVLYYLQSLLSLHGVEDEMQREQIKKMIYMSPLM
                     IVVFSLFSPASVTLYWVVGGFMMILQQFIVNYIVRPKLRKKVREELAKNPPKASAFSK
                     PSGRKDVTPEQPTAITSKKKHKNRNAGKQRSR"
     gene            complement(29471..30265)
                     /gene="pflA"
                     /locus_tag="VVR18_000587"
     CDS             complement(29471..30265)
                     /gene="pflA"
                     /locus_tag="VVR18_000587"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HEU6032163.1"
                     /translation="MSEETIDYGQVTGMVHSTESFGSVDGPGIRFIVFLQGCHMRCQY
                     CHNPDTWAMESNKSRERTVDDVLTEALRYRGFWGNKGGITVSGGEALLQIDFLIALFT
                     KAKEQGIHCTLDTCALPFRNKPRYLEKFDKLMAVTDLVLLDIKEINEEQHKIVTSQTN
                     KNILACAQYLSDIGKPVWIRHVLVPGLTDRDDDLIELGKFVKTLKNVDKFEILPYHTM
                     GEFKWRELGIPYSLEGVKPPTADRVKNAKKLMDTESYQDYMKRVHG"
     gene            complement(30391..31641)
                     /locus_tag="VVR18_000588"
     CDS             complement(30391..31641)
                     /locus_tag="VVR18_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000856498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HEU6032164.1"
                     /translation="MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWN
                     KGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTSD
                     KEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
                     FGMTKDQLFEAFAILKEKGAKTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLG
                     IWLDFINLSGGIGVNYRPDQEPNDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFM
                     LAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDV
                     VGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGK
                     ARQIRRAERPEDYFATLYGFDFEE"
     gene            complement(31708..32535)
                     /gene="purR"
                     /locus_tag="VVR18_000589"
     CDS             complement(31708..32535)
                     /gene="purR"
                     /locus_tag="VVR18_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004242125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HEU6032165.1"
                     /translation="MKLRRSDRMVVISNYLINNPYKLTSLNTFAEKYESAKSSISEDI
                     VIIKRAFEEIEIGHIQTVTGAGGGVIFTPSISSQDAKEMVEDLRTKLSESDRILPGGY
                     IYLSDLLSTPAILKNIGRIIAKSFMDQKIDAVMTVATKGVPLANAVANVLNVSFVIVR
                     RDLKITEGSTVSVNYVSGSSGDRIEKMFLSKRSLKAGSRVLIVDDFLKGGGTVNGMIS
                     LLREFDSELAGVAVFADNAQEEREKQFDYKSLLKVTNIDVKNQAIDVEVGNIFDEDK"
     gene            complement(32802..33743)
                     /locus_tag="VVR18_000590"
     CDS             complement(32802..33743)
                     /locus_tag="VVR18_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exoribonuclease YhaM family protein"
                     /protein_id="HEU6032166.1"
                     /translation="MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEI
                     DGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNTPQVNQITLRLPQAGEPNDPADFKVK
                     SPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFETGLAY
                     HTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIA
                     LIDSEITKTVMELGIDDTKEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNL
                     DASMMMMSTALALVDKGEMTNKIFAMDNRSFYKPDLD"
     gene            complement(33733..34989)
                     /locus_tag="VVR18_000591"
     CDS             complement(33733..34989)
                     /locus_tag="VVR18_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HEU6032167.1"
                     /translation="MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQ
                     LDYRFDQARQASQLDQKDLEVAVSDRLQEVRIELHQGLTQVRQEMTDNLLQTRDKTDQ
                     RLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQTVAR
                     DVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPG
                     QGDQEYVYLPIDSKFPLADYYRLEEAYETGDKDEIERCRKSLLASVKRFAKDIKSKYI
                     APPRTTNFGILFVPTEGLYSEIVRNPVFFDDLRREEQIIVAGPSTLSALLNSLSVGFK
                     TLNIQKSADHISKTLASVKTEFGKFGGILVKAQKHLQHASGNIDELLNRRTIAIERTL
                     RHIELSEGEPALDLLHFQENEEEYED"
     gene            complement(34991..35653)
                     /locus_tag="VVR18_000592"
     CDS             complement(34991..35653)
                     /locus_tag="VVR18_000592"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000006147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HEU6032168.1"
                     /translation="MSEYKLSENNWTRVAVFAGGNRGHYRTDFDAFVGVDRGSLWVLE
                     EDLPLALAVGDFDSVTEEERQVIQKRAQYFVQARPEKDDTDLELALLTIFEQNPQAQV
                     TIFGALGGRIDHMLANVFLPSNPKLAPYMRQIEIEDGQNLIAYCSEGTSQLEPRSDYD
                     YLAFMPVRDSQLTILGAKYELTEENFFFKKVYASNEYIDREVSVTCPDGYVVVLHSKD
                     RR"
     gene            complement(35616..36272)
                     /locus_tag="VVR18_000593"
     CDS             complement(35616..36272)
                     /locus_tag="VVR18_000593"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HEU6032169.1"
                     /translation="MSQYKIAPSILAADYANFEREIKRLEATGAEYAHIDIMDSHFVP
                     QISFGAGVVESLRPHSKMVFDCHLMVSNPEHHLEDFARAGADIISIHVEATPHIHGAL
                     QKIRSLGVKPSVVINPGTPVEAIKHVLHLVDQVLVMTVNPGFGGQAFLPETMDKVREL
                     VALREEKGLNFEIEVDGGIDDQTIAQAKEAGATVFVAGSYVFKGEVNERVQTLRKQLD
                     "
     gene            complement(36283..37161)
                     /gene="rsgA"
                     /locus_tag="VVR18_000594"
     CDS             complement(36283..37161)
                     /gene="rsgA"
                     /locus_tag="VVR18_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HEU6032170.1"
                     /translation="MQGQIIKALAGFYYVESDGQVYQTRARGNFRKKGHTPYVGDWVD
                     FSAEENSEGYILKIHERKNSLVRPPIVNIDQAVVIMSVKEPDFNSNLLDRFLVLLEHK
                     GIHPIVYISKMDLLEDRGELDFYQQTYGDIGYDFVTSKEELLSLLTGKVTVFMGQTGV
                     GKSTLLNKIAPDLNLETGEISDSLGRGRHTTRAVSFYNLNGGKIADTPGFSSLDYEVS
                     RAEDLNQAFPEIATVSRDCKFRTCTHTHEPSCAVKPAVEEGVIATFRFDNYLQFLSEI
                     ENRRETYKKVSKKIPK"
     gene            complement(37163..38035)
                     /gene="rsmA"
                     /locus_tag="VVR18_000595"
     CDS             complement(37163..38035)
                     /gene="rsmA"
                     /locus_tag="VVR18_000595"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HEU6032171.1"
                     /translation="MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEI
                     DDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLVPILADTLRDFDNVTVVNEDIL
                     KVDLAQHIQNFKNPNLPIKVVANLPYYITTPILMHLIESGIPFCEFVVMMQKEVADRI
                     SAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVED
                     ENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLA
                     EFAGLADALKGQGL"
     gene            complement(38286..38579)
                     /locus_tag="VVR18_000596"
     CDS             complement(38286..38579)
                     /locus_tag="VVR18_000596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032172.1"
                     /translation="MCEKIRIRRVSDYPSARGGLEDILIMENMTNHLLLVQILVHGYL
                     LDFASIEGQRQKHYRLKNLPQTVELTVDDVEEDVDLTLPENRSYQEADFFDTQ"
     gene            complement(38572..39213)
                     /locus_tag="VVR18_000597"
     CDS             complement(38572..39213)
                     /locus_tag="VVR18_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032173.1"
                     /translation="MIDIQGLEKKFNDRAIFSGLNLKLEKGKVYALIGKSGSGKTTLL
                     NILGKLEKIDGGRVLYQGKDLKTIPTREYFRDQMGYLFQNFGLLENQSIKENLDLGFV
                     GQKISKVERLEKQVGALEKVNLGYLDLEQKIYTLSGGEAQRVALAKTILKNPPLILAD
                     EPTAALDPENSEEVMNLLVDLKDENRIIIIATHNPLVWNKADEIIDMRKLAHV"
     gene            complement(39215..>40426)
                     /locus_tag="VVR18_000598"
     CDS             complement(39215..>40426)
                     /locus_tag="VVR18_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU6032174.1"
                     /translation="KGKLPLKRMMTLMMVGQLLAVLVVGSSATALLPHYREMQEMERA
                     SNKWSQSSDRYRLSFGWSSAFADEEGTRKDNREWQTFTEERLANTDSFYIMSNVDNFS
                     DGAEVDLDGNRLSDYTPSGNVIYVSPRYLIEEKITVSSEFMDKMQNLSEGEFGLILPE
                     SLREQSTYYQRLFTDYLQNFSSESVEVTSQKYYLPQVSLAFTETGQERFLYNDGYKTT
                     RQYLKDPIIVVLTPQATGTRPVAGILWGTTANSALKLDRYGDSITALKEQGLYHKVSY
                     LVKSQLFFAKVLNDKRVEFYSLLIGTILTLSTAILLFDSMNLLYFEQFRRELMIKRLA
                     GMTIYELHGKYLLAQGGVLLLGLVLSSILTRDGLISALVVALFTLNALLILVRQDKKE
                     EAGSMAVLKGK"
BASE COUNT        11525 a         9175 c         7736 g        11990 t
ORIGIN      
        1 agttgttcat atcttatttc aagctactat atataatcta aaaacttgaa tcaaaaatcg
       61 aaaaagtagc ggatttctcc actgctttaa cagcttattc ttcaatttcg atttcaagtt
      121 catcgcctaa gtcaagcgta acttcttcat tcactgcttc ttctttcttt ggctcatctt
      181 ttttgttttc agtatcttgt tctgaaactt cttctccatc aatcaagcca aatttagaac
      241 ggacttgctt atcaatttca tcaaagattt ctgggtgctc tgccaagtat ttcttagcat
      301 tttcagaacc ttgcccaatt ttttcatctt tgtaagaata ccaagcccct gcttttttga
      361 taatatccaa atcgcttgca atcttcaaaa gctcaccagt cttagaaatt ccttctccgt
      421 acataatttc aactacggct tccttaaacg gtggagctac cttatttttt acaaccttaa
      481 tcttagtttc tttaccgaca ttggtttctt tttggtcacc agttccctta atttgtgtat
      541 taccacgaac atccaagcgg actgaagcat agaatttcaa agcacgtccg cccggtgttg
      601 tttctggatt tccaaacatc actccaactt tttcacgcaa ttggttgata aaaatggcaa
      661 ttgttttggt tttattgata gaggcgccaa gtttacgcat ggcctggctc atcatacgag
      721 cctgcaaacc aacatggcta tctccgatat ctccatcaat ttccgcacga ggaacaaggg
      781 cagcaactga gtcgactacg acaagatcaa ctgcacctga gtcaatcaat tttcccgcaa
      841 tctcaagacc ttgctctcct gagtctggtt gagacaagag caattcgtca atattgacac
      901 caagggccgc agcataagct ggatcaaggg catgttccgc atcgataaag gcagcaatcc
      961 caccttcttt ttgcgcttgt gcaactgcat gaagggcaac cgttgtctta ccagatgact
     1021 ctgggccata gatttcgatg atacgtccct taggataacc acctgagcca agggcaatgt
     1081 caagagctaa agaacctgag ctcatcactt gcaccttttg ctccgcacgt tcacccaaac
     1141 gcatgattga tcctttacca aagtctttct caatcaattt aagagcgtca ttcaaggcct
     1201 tttcacgttc tgccccaaat ttttttgaaa tttcttctaa tttttttggt tttttcgcca
     1261 ttctattctc ctacattcta atgatcctca gacctatcta ctattatatc aaaagttagt
     1321 cacttaataa agccttgcga actaggttaa aggcatgcat aaccgcaata tgacgtacat
     1381 ctgctcggct tctgcctcca atattaacct tgataacctc agttccttgc tcttgcgcca
     1441 agcctatgaa gactgtccca actgggtgtc cttctaggct atctggtcct gccactccgg
     1501 tcaaactaat tccaaaatca gactgggtct tgcttcgtgc ctgctcagcc atcttctgag
     1561 ctgtaaattc agacaccaca ccatgttctt ccaaattctt ggcaggaata tccaacatcc
     1621 ttgatttttc ctccaagcta taggtcacaa aaccaccctt aaatatactt gaagctccag
     1681 aaaaattcgc cacggtagct tggaaaagac ctgccgtcaa actctctgca gccgcgatgg
     1741 ttttcccttg ccttttcagt tcttctacca caatgctggc taaactagtt tcttccccat
     1801 aaccatagca aaagtctcgt aaagaaattc cttcgaaagt ctggcagtcc aagatttgat
     1861 tttccaagat atccagcgct tgattcgcct cttcttgact gctagccttt gttgacagac
     1921 gtagagtgac ttctcctgtc ttggcataag gggccaaggt aggatcgatc tgattatcaa
     1981 ttaaatcagc caaaatcgta accaactggc tctcgccaat cccaaagaaa cgaagaactc
     2041 gggaatacag cttgctccct gtcatcaact tgggtagaag ttggtttaag accatgggtt
     2101 tcaattcact tggcggacct ggaaggacga cataggtcac tccgtctact tctaattttc
     2161 ctccaacagc cagtcctgtt tcgtttggca gtggaatcgc tccttctaca atttgagctt
     2221 gtctttcgtt attcggtgtt cgggcatagt ctggtcgcag ggcaaaaaag atatccaact
     2281 tctcctgagc ctgaggatca aagactaatg ctttccctaa aaatttagct agggtttgtt
     2341 tggttaggtc gtcctcagtt ggccccaaac cgcctgtcaa aatcaccaga ctgctacgtt
     2401 gactggcaat ctcaagcaaa gacaagagac gaacttcatt gtctcctaca gccgtctgaa
     2461 aatatacatc taccccaatc tcagctagtt tttccgacaa aaactgggca ttggtgttga
     2521 caatctgccc tgtcaaaatc tctgttccaa cagcaatgat ttctgctttc atgtttcctc
     2581 ctacctatct attcgtattt ttttgaaaaa atcgcaggaa ttttcctacg attgattttt
     2641 ttatttgtat caaaagttaa ttatcttcat caccaacagg tgctctgcca aataaatctt
     2701 caaataaaac cgcattggtt tcaagctgag taacttcttc ttgtcccaaa gaacgtcgga
     2761 gtatattttg catttccaac atatgtgctc tcgaaacaat ctggtaagaa acaccttgaa
     2821 gtatctctcc ttcaccctgc aactgctgag tttcaatggt tttaaatgaa tctttatagc
     2881 ctagcaagtt agggatactt tttgcagaca aatcaatatt ggtctgcata ttgtcactca
     2941 aagcttttag aatctcttga taatgaccaa tgctatttaa actgagagct ttttccatga
     3001 ctttttgaat aacttcacgt tgacgttttt gacgaccata atccccctca ggatcttggt
     3061 aacgcattcg tgcatagact agggcttctt ctcccccaat atgttgctcc ccaacaccga
     3121 tagaaatggt attaaattct tcttggtcac tgatagaaat tgggaaacct aggatattat
     3181 tgactgtaat acctcctact gcatccacta gtttttgcaa ccctctcata ttgaccatca
     3241 catagcgatc aatatggata ttcatcattt tttgaatggt ttctatagca agctctgctc
     3301 caccatctgc atatgctgag ttcagtttcg cttcatgagc ctgaccattc cctgattcaa
     3361 tgcgcgtcag aatatcccgc tctaaactca tcattgttgt ttttttcgtt ttaggattca
     3421 ctgtcatcaa gatcatgcta tcacttctac cgacccaagt ttcagttcgt tcaacatttc
     3481 cggtgtccac tcccattaac agaatggtta gaggttcagt cgcttcaata accttggttt
     3541 cttcgccgat ttttttatag gttttagcta aggtttctgt cccttgttga taaatagtat
     3601 aagcaaaaac acctactcct actacagtta cagaaagtaa agctagcacc attccaataa
     3661 tttttttaac catatttcta ctaacctatc agtttaccca tcaagtaaac atcgataaat
     3721 ttcccttctt ctatatatgc cccacgctct tggctacctt caatgacaaa gccatgcttt
     3781 tgataaagat ggactgctgc ttgattacga gtttggacag tcagttggag acgacgcaga
     3841 atgccacttg cttgtgccca ctctatcgct tcttctagca acaaacttcc caagccatta
     3901 ttccaatatc tttttccaat cacaatgaag agatctccaa tatgacggac tctcttacgc
     3961 tgatcagctg taatatttac aataccagca attttgccat ttaagaatgc aagtaaggtt
     4021 atctgattgt ccgaactagc ttgcttgttg aggaatattt ccatctcctc actagtcaag
     4081 agaataccat ctccgtctag gctggtaaag tctgtctcca aactcacacg atttaaaaag
     4141 gccactaatt cagctgcatc tttgggctct gcttccctaa tgagcaattc atactccata
     4201 ttgaagctcc tctaacaatt tctcagcacg caaacccttt gcctgaaaat ttaaacggcg
     4261 tccatctgct tcttttagaa tttccaattc taaataagca tctggcaagg catctcctaa
     4321 gagatttccc cactcaataa cagtcacgcc gccaccaaag ataaactcat ccaagtcgat
     4381 agaatcagca tctccttcaa tacgataaac atctaggtga taaagtggaa gtcgaccttc
     4441 atactctctc acgatagtat aggtgggact tttaatcatt tgagaaatct gtaatccttt
     4501 tgcaagtcct ttagtaaagg tcgttttacc tgcacccagt tctccagtta agattaaaac
     4561 atcattcttt gctaatagat ggcccaaacg ctcccctaag gcttgcaact cttcttcatt
     4621 ttttgtgtac atactcttat tataccaaaa acttttcttt tgtgtctatt ttcctactaa
     4681 acttatcatc ataacatcca tacaaaaaca ggctttctct aaaagaaaat gagcgtaaca
     4741 atgaccaata caagatctcg gaaaatatga ccataaaagg atacttcctt cttaaccgaa
     4801 tttgggacaa gataggctgc aaaaaacaag cccagtccaa tataaatcag aagtgagaca
     4861 atggtcattg gatttcttaa gaaaagaagt gttgctaaaa tagtcaccaa cactgtcttt
     4921 tttctgtcta gcatagcaag aaaatcgcgc acgtattttt tcaagggtaa aaaaatcagc
     4981 aaatctagcc caaataggaa aaagaaggat ggcaataaaa agtcaactaa ttcttgctgc
     5041 agcgtatttt tgatgaacaa gttatctgac aaaacaagaa cagctcctaa caaattaatt
     5101 aagagtaaca tactgtaaaa aagcttcacc gacttcttac tggctaggac actatggact
     5161 tcttgcttac gggtataaag ataatttact ccagcacaga ttcctgaaac gaaaaccatg
     5221 cttccgatga aaaaagctgt actttgttta aaggacaaga tgcattcctt ccataggaaa
     5281 cagctactca aactgatttg aattaaagct aacaaaaata agattctcat tgatttcatc
     5341 ttctctctcc cttcctacca atcattatac taggagaaaa gagagaactg tttctaatct
     5401 tctcaaatgt ctctttaaga cgctaaacaa acactagaga ctaatactca atgaaaatca
     5461 aagagcaaac taggtagcta gccacaggtt gctcaaaaca ctgttttgag attgcagata
     5521 gagctgacgt ggtttgaaga gattttcgaa gaatataaat ttgaaatcat gaaaatccgt
     5581 caaacgggtg gttgttttgt ctcgcacctc acggagcgag acggactcag agtcacataa
     5641 ttataaggct gatagtatta atctaactat cagccttaca ggctatttaa tgtttaagta
     5701 acactccaat atcaagataa actaaacagc atctagttcc ttcaaataat tttctatctt
     5761 catcagcatt aaaggattgt tataaatctt gcatagctct cttgcttcta tataataatt
     5821 tttgacttgt tctctgtcta gaaatttggc tccagcattt cctacaagaa taagtagagg
     5881 agccaattgg tagcttgtct gtctttgttt acagagttca atcgtttcaa gagcttcttg
     5941 gatggcttca ttatattttt cctttgatac taggtagtga gcgtagttgt aacgaactct
     6001 gatgtagcca aataaaaact cttgatggtc caaatttttt gtctgataca actctattaa
     6061 atgagagtag tttgcctcat attcttgttc acgacccact aaggaataga aattagatag
     6121 agtattcaac gcctttaaat aaatcagagt atttgaagag acttttaata atatattttc
     6181 caatgaagaa attgcctcac acttactgtc atattgatat aagtcaataa tagctttaat
     6241 ccattcaagg taagttcggt cttctagtgt tagaaaagta cttcgttcaa tctctattct
     6301 ataaatatat tccaaatcgt cataatttct atcgtctaat agtcgagcag acaattgctt
     6361 gaaattagag aggttagatt taatttcaat ttgttcatta aaaaaataat ctaatggtac
     6421 ttcaagtcgt tgagagagtt tgaacaaaag gtctgcggag ggaatgaaat gccctctctc
     6481 aattttacta atctggcttt gttcacaaat tccttctgca agagtttgtt gggagagtct
     6541 caactctttt cttttcaatc tgaatttctc tgcgagtgta ttcattaaag ataataaacc
     6601 ttcctatttg cttaattgca ttataaaatt tttagttcaa aatagcaagt taaaggaata
     6661 aataattctt tatggtaata aactaaaaaa agtcaaaaat tacataaaaa tgcttggcta
     6721 aataaaatat atctgttaaa ataaggataa tgaaaaagaa aagggtttca cgaatgaaga
     6781 aaaatcgtgg aattcaaaaa ttagctatat tagtattact aggtgttttt atgtttagta
     6841 atacaattcc ttaccaacag tttattcaga agaatagaca attggagatt cgagtgcaat
     6901 cgcaaaagaa gtccaatggt cttgatgttg ggaaggctga ttgatttcgt attactttaa
     6961 aattcaacta tttagagaaa ggtattctga tgagagcttg taacaatacc agatagatat
     7021 tagtaagctt gttagtttat agagggcagg ggtatttctg ccctctgttt tagaataagg
     7081 aatgcactat gaaaaaatta tttatactca tatccaacct gcttgctagt ttgttctttg
     7141 tttgggtatt taccatttgg actgatacat atgtctccta ttattacccc aacgttgttg
     7201 tacatgattc ttcccctgaa acaacttttc agcatgttgc tacacgcttg gaaaaactag
     7261 cagaagaaac agatagcttt attgcgattc aacaccaaga ttctaactca gaaggtacta
     7321 cagttttttc ttatacgacc tttggggacg gaaagttgcc tgatgggctt caggaaaaaa
     7381 atctagaaga tgctcaaagt agtagtgttg aaacaaacta ttttgtattc gatggacacc
     7441 tagatattca cttgctaagg gaagagctaa gtcaacttgg cttgactaac atgcacctga
     7501 caattccatc taaactatct acgttaatgg ctatctttag taacggattt cagttaatca
     7561 gtctattgat tttcatctta acctttgtag cactgacttt aattagtcaa attagccaat
     7621 tacggtcatc gggcattcgc ctcatttcag gagagaaacg gtggtccatt ttccttagac
     7681 cagttggtga ggatttgaaa gcgatagctg ttggtttcag tttagctggc gtgctcgcca
     7741 ttcttatgca aaaaattctg tcgcttccaa cgcaatccct aatgaccata ggagcaggct
     7801 tgctcagtta taatctcatc ttgttgtcga tctccctgtt tttcgctcaa ctcttcgcag
     7861 ttgggataaa aaagatacac ctgatgcaga ttataaaagg gcaagtgcct gtcagaggaa
     7921 tcattagttt gattttaatc ggtcaactgt tagcgattat tattgtaacg ctgggaatag
     7981 ggagtagctt aaagtattcc caagcctggc aacagcatcg gattggacaa gaggcttgga
     8041 gtcaggaaag gcaactgatt accctatcaa tcagccgtga aggaacgagt cctggttttg
     8101 atgaacaagc tcaaaggaaa ctcagaactt ggtatcaatt gatggatctg gctgtttcag
     8161 aacaaaaggc tttcttatct agacaccagt taattgaccg tactttgcaa aatggcatgg
     8221 cttcctccaa aaacttgata acctctacag aatggcacga ttacaaccca aatggcaatg
     8281 tccttatcgt cacaccgcaa tacttggagc gtcaaaacat tcctgtagat acaactattg
     8341 agcaaaagat gaatcacctt gatgtagggg agtttgtctt attgctgcct gaacacctcc
     8401 gttcagagga agaacattat aaatctgttt ttgaagacga cttaaccagt cgcatgtcta
     8461 gtcaagatga acgacagcaa atgactgcta cggtaggtta tttagaatca ggtcaggatc
     8521 gttttgtgta taatacgacc cctatttctt accagcagtt tttgaaagat ccaatcatca
     8581 ttgttataac accccaatca actggtccac agtccatttt gttttggata gacgcagtac
     8641 agaactacgt tctctttaat caattgtctg atgcccagga gcttatccag agacaaggca
     8701 ttgaaaattg ggtctcagaa atgcaaacag gttaccacaa ctacatcaca ttattggata
     8761 atatccagag ggaacgttgg gtaatgctag caggagctgt gcttgggatt gcaacttcaa
     8821 tcttgttgtt taacactatg aataggctct actttgaaga atttagacgt gccattttta
     8881 tcaaacgcat tgcaggtctc aggttcttag aaatccatcg cacttatctc tttgctcaac
     8941 tgggtgtgtt tttactggga tttgttgcga gtgtatttct tcaggtagag ataggagttg
     9001 ctttcttagt cttgttactc tttactggtc tatctctttt acagttacat gtccaaatgc
     9061 agaaagaaaa caagatgtcc atgcttgttt tgaagggagg ttaatatgat tgaacttaaa
     9121 caggtgagta aatcttttgg agaacgagag ttattttcga atctttcaat gacatttgag
     9181 gctggaaaag tctatgcctt aattggttca agtggtagcg gaaaaacaac cttgatgaac
     9241 atgattggga aattagaacc ttatgatggg acgatttttt accgaggtaa agacttggcc
     9301 aattataaat cgagtgattt tttccgtcac gaattgggct acctcttcca gaactttggc
     9361 ttaattgaaa accaaagtat tgaagaaaac cttaagctag gtctcattgg tcaaaagttg
     9421 agtcggtcgg aacagcggtt gaggcagaag caggctttag aacaggtcgg cctggcttat
     9481 cttgacctag ataagcgcat ctttgagtta tcgggcggag aatcgcaacg ggttgccttg
     9541 gcaaaaatta tcttaaagaa tccacccttt attctggcag atgagccaac agcttcaata
     9601 gacccagcaa cctctcagtt gattatggag attttgctat ctcttcgaga tgataatagg
     9661 ctaatcatta tcgcaacaca taatccggca atttgggaga tggctgatga agtgttcacg
     9721 atggatcatc tgaaataaaa atccttgttt ttaattgcac gatgagttac tgaaatatta
     9781 tcatgaatca agaattggag ttaatttaga attgtacttt attaatattg aggtaacttt
     9841 ttcttgataa aggaagaaat aatggagagg aagttagaat gaaaaaattc gacaattata
     9901 ttattgagaa gccttgcgat tctaattcag ataaactgca aaaaatctta ataattgaaa
     9961 atttggtaga tgatattttg caatttcctc tcagaatcaa taatagtgta ggagagattt
    10021 tcctcctaca accgtttcaa aagaaaacta tctttattcc atgttatttt gaggaagata
    10081 ttgtgaaagt caaagatgat gataaagttg agtggaattt gttagaattt caaaaattta
    10141 gagcattttt ggcttagtaa tctgtgttga aggctcaaaa cctatggtaa aaaagtcgct
    10201 ttgaaaacgt attgcctcca aagatttagt taaataatga tttaacacaa aaagaaatta
    10261 ttgaagttct ggaaagatgt tgtttcagta ttgagaaaag atgggaaaaa cttgcgattt
    10321 tcacagagaa aggaagaaaa agtatagaaa tatagtcaat tgaaacaaga acaggacaaa
    10381 agaacctttt gtgccatatt tttctccttt cgctttacaa ttggcttgaa cacctttatt
    10441 gtatcgcgtt tggagttttt ttggtataac cttcgacgcg cacccgcata gtgggtgttt
    10501 ttttgtctcg cacctaacgg agcgagacaa actaatagtc acttaatcaa aaaacgcacc
    10561 atatcaaaaa ctaaaaagtt tgatatcatg cgtcatgtct taaactaatt gactatactt
    10621 tctattcaaa tgagctttta accaattgat tgagccaatc cactcttaaa accaaagagc
    10681 aatttctcgc ttagctgact cttctgaatc tgaaccatgt acaacatttt ggataatctc
    10741 attttctcca gcagcttttg caaaatcacc tcgaatagtg cctggtaaag cttcttctgg
    10801 acgagttgca cccatcatgg tccgccaagt ttcgattact ttgggaccag aaatgacacc
    10861 cacaagaact ggacctgaag tcatgaattc acgaatcggt gggtaaaaac tctgaccaac
    10921 caagtcctga tagtgctggt caatcaactc ttctgaaacc tgtgaacgaa actccaattt
    10981 ttcgattgta aatccacgtt gttcgatgcg ctttaacact tcacccacta gccctctttt
    11041 tacaccatct ggtttgatga taaagaatgt ttgttccata cccgtctcct ttgtcagctt
    11101 ctttctttta ttttaccaca tttcgtggaa aaatggagaa agttttcaga agagagaatg
    11161 agagaaccct cgggttctct cattctctct tattctactg tttcttccac agtttcaacg
    11221 gcagtatcca caactacttc tgttgtttct tcatttcctt cttcctctac tggaggatta
    11281 aggtattctt cttcgttgac agcatatggt tcaaggttac ggtaacgggc cataccagta
    11341 ccagctggga tgatcttacc gatgataaca ttttctttaa gtccaaggag atggtctttc
    11401 ttaccacgga tagctgcgtc agtaaggaca cgagttgttt cctggaagga agccgctgac
    11461 aagaaactgt ttgtttcaag tgaggctttg gtaattccca taaggactgg gcgacctgtc
    11521 gctggaactc cacctgcgat aaggacatct ttgttggcat ctgtaaagtc attgatatcc
    11581 atgagggtac ccatgagaag atctgtatca cctggatcca tgacacggac tttacggatc
    11641 atttgacgaa ccattacctc gatgtgtttg tcaccgattt ctaccccttg gctacggtaa
    11701 actttttgta cttcaccgag aaggtacgtt tcaactgaca agacatcacg aactgcaagg
    11761 agacgttttg gttggataga accttctgtc agagcagcac cacgcgctac ttggccccca
    11821 acttcgacac gcatacgagc tgtaaatgga acgacatatt caccttcgcc agtttcaccc
    11881 ttaacaaaga ctttcttggt acgagttgat gcatcttctt cgatagcagt aacttgtcct
    11941 ttaacctctg taataaccgc ttccccttta ggattgcggg cttcaaagat ttcttggaca
    12001 cgaggaagac cctgagtgat atcggtattt gaggcaaccc cacctgtgtg gaaggtacgc
    12061 attgtaagct gtgtaccagg ttccccgata gattgggcag cgattgtacc aactgcttca
    12121 ccaacttcaa ccgcatcacc agtcgccaag ttgataccgt aacagtgacg gcagacaccg
    12181 tgacgagtgt tacatgtaaa tacagaacgg atagtcactt cttccacacc agcattgaca
    12241 atttcacgcg ccttgtcttc tgtaatcaat tcatttggac caataatcac tgcaccagtt
    12301 tctggatgtt taacagtttt cttagtgtaa cgaccgttga gacgctcttc gagagactct
    12361 atcatctctt ttccttctgc gatagaacgg atcaagagac cacggtcagt tccacagtcg
    12421 tcctcacgga tgataacgtc ttgggcaacg tcgaccaaac gacgagtcaa gtaacctgag
    12481 tcggctgtct taagggccgt atcggtcata cctttacgag caccgtgagt tgagaagaac
    12541 atttccaata ccgacaaacc ttcgcggaag tttgaaagga ttggcaattc catgatacgt
    12601 ccattcggag cagccatcag accacgcata ccggcaagct gtgagaagtt tgagatgtta
    12661 ccacgggctc cagagtccat catcataacg attgggttct taggatcttg attagcaatc
    12721 aagcgtttct caagtttttc acgggcagca cgccattcag ctgtaacagc attgtaacgc
    12781 tcgtcgtctg tgatcatacc acgacggaat tgtttggtga tttgttcgac acgtttgtgt
    12841 gattcttcaa tgatttcagc cttgtcatca acgactggga tatcggcaat acccactgtc
    12901 aatcctgcaa gagttgagtg gtggtaaccg aggttcttca tgcggtcaag tagggcagaa
    12961 gtttctgtcg tacggaaacg tttgaagatt tcagcgatga tatttccgag gtttttcttc
    13021 ttgaatggag ggttgagctc aagattgctg atagcttcct tgatatctcc accaagtggc
    13081 aagaagtatt tagctggaac accttctgtc aagttggcat tgtttggttc ttgcaagtat
    13141 ggtagcccct ctggcatgat atcgttgaag agaattttac caactgttgt aagcaagacc
    13201 ttatgtcttt gctcttctgt ccaaggcttg ttgaggctgt ctgttgcgat accaacacgt
    13261 gagtggaggt gaacataacc attgcggtaa gccataaccg cttcgtcacg gtctttgaag
    13321 accattcctt caccttcgcg accagcttct tccatggtca agtagtagtt acccaaaacc
    13381 atgtcctgag atggagtaac taccggtttc ccatctttcg ggttcaagat gtgctcagca
    13441 gctagcatga ggatacgagc ttctgcttgt gcttcttctg aaagtggtac gtggatggcc
    13501 atttggtccc cgtcaaagtc agcattgtag gcttcacaga caagtgggtg caagcgaaga
    13561 gccttaccat caatcaagac tggctcgaag gcttggatac ccaaacggtg aagggtcggt
    13621 gcgcggttca aaagcactgg gtgttcttta atcacttctt caaggatatc ccagatacgc
    13681 tcatctccgc gttccaccaa gcgtttagct gctttgacgt tttgcacgat atcacgggca
    13741 acgatttcac gcatgacaaa tggtttaaag agttcaatcg ccatttcacg tggcacacca
    13801 cattggtaca tcttaagagt tggaccaacg gcgataacgg aacgtcctga gaagtcaaca
    13861 cgtttaccga gcaagttttg acggaagcgt ccttgtttac ctttaagcat gtggctcaat
    13921 gatttcaatg gacggctacc tggtcctgtg attggacgac cacgacgacc attgtcaatc
    13981 aaagcgtcaa ctgcttcttg aagcatacgc ttctcatttt gaacgatgat acctggtgca
    14041 tttaactcaa gcaaacgagc caaacggttg ttacggttga taacacggcg gtaaaggtca
    14101 ttcaagtcag atgaggcaaa acggccacca tccaactgca acattggacg aagatctggt
    14161 gggataaccg gaaggatgtt aagaatcatc cattcaggtt tgtttccaga cttgtaaaag
    14221 gcatccaaaa catccaaacg acggatggct ttgacacgtt tttgtccagt agctgttttc
    14281 aattcttctt tgagttcagc aatttctttt tcaagatcta cttgcttcaa aaggtcttgg
    14341 atggcttccg cacccatctt ggcaacaaat gaaccataac catattcacg caagcgctct
    14401 cggtattcgc gctctgtcat gatagacttg tgctcaagtg gtgtatcctt aggatcaatt
    14461 accacataag ccgcaaagta gataacttcc tcgagggcac gagggctcat atcaagggtc
    14521 aagcccatac ggcttggaat ccccttgaag taccagatgt gagatacagg agctttcaat
    14581 tcgatatgtc ccatacgctc acgacgaact ttcgtacgcg ttacttcaac cccacagcgg
    14641 tcacaaacaa ttcctctgta acgaatgcgt ttgtacttac cacaagcaca ttcccagtct
    14701 tttgtaggac caaagatcac ttcatcaaag agtccttcac gttctggttt caaggtacgg
    14761 taattgattg tttcaggttt tttgacttct ccataagacc atgaacggac tttacttgga
    14821 gaagctaggg tgatttgcat acttttaaaa cgatttacat caaccactat ttcttccctt
    14881 tctattctaa gtgaactgct tattcctgtt cagcagcttc ttctgttgct tccgcttttg
    14941 ttgctttctc agcttcttca gcttcaaagg ctgctttagc ctcttgggct gctttttcgc
    15001 gggctttttc aaggtcatct acgtggatga catcttcgtc cattccttca tccaagtcgc
    15061 gaagttccac ttcttggtca tcttcgtcta ggacacgcat gtcaagacca agagattgca
    15121 attctttgac aagaactcgg aaggattctg gaacacctgg ttttggaatt ggtttgcctt
    15181 ttgtaatagc ttcataggct ttcaaacgtc cgttgatatc gtccgacttg taagtcaaga
    15241 tttcttgaag gacatttgac gcaccgtagg cttcaagagc ccaaacctcc atctcaccga
    15301 aacgttgtcc accaaactga gctttacctc cgagtggttg ttgggtaaca gttgagtaag
    15361 gtccgactga acgcgcgtgc aatttatcgt caaccatgtg gtggagtttg atcatgtaca
    15421 tgactccaac agaaacacgg ttatcaaatg gttcacctgt acgtccatcg taaaggattg
    15481 tcttggcatc gctatccata cctgcttctt taacagttga ccaaagatct tcagaacttg
    15541 ctccatcaaa gactggtgtc gcaatgtgaa taccaagagt acgagctgcc ataccaaggt
    15601 gaagctccat aacctgaccg atattcatac gtgatggcac cccaagtggg ttcaacatga
    15661 tgtcgactgg agttccgtct ggaaggtaag gcatgtcttc tacaggaacg atacgagaga
    15721 caaccccttt gtttccgtga cgtccggcca ttttatctcc gaccttaatc ttacgttttt
    15781 gagcgatgta aacacgaacc aacatgttaa cacctgattg caactcatct ccatttacac
    15841 gtgtaaagat cttaacatca cgaacgacac catcggcacc gtgtggtaca cgaagagaag
    15901 tatcacgcac ttcacgagac ttgtctccaa agatagcgtg caagagacgt tcttcagctg
    15961 aaagatcttt ctcaccctta ggtgttactt tacctacaag aatatcacct tctttaacct
    16021 cagcaccaat acggataatc cccatttcgt caaggtcttt gagggcatct tcaccaacgt
    16081 ttggaatttc gcgagtgatt tcttcaggcc caagctttgt atcgcgcgtt tctgattcgt
    16141 attcttcaag gtgaacagat gtgtagacat cgtccttcac caagcgttcg ctcatgataa
    16201 cggcatcctc gaagttgtaa ccttcccaag tcatgtaggc aacgattggg ttttgtccaa
    16261 gcgccatttc tccattttcc atagaaggtc cgtcagcgat gaaatcgcct ttttcaacga
    16321 catcaccaac ttttacgaga gtgcgttggt tgtaagcagt acctgagttt gaacgacgga
    16381 atttttggat gtggtaaaca tccaatgaac catcttcacg acgaacttct accttgtcag
    16441 catctgcgta agtaacttta ccatcatact gagcaatcac agccgcacca gaatcgtggg
    16501 ctgcttggta ttccatacca gtaccaacgt aaggtgcctg aggattaatc aatggcacag
    16561 cctgacgttg catattggct cccatgaggg cacggttgga gtcatcgttt tccaagaaag
    16621 gaatacatgc tgtcgcaacg gcaactacct gttttggtga aacgtccatg tagtcaacaa
    16681 tattagctgg atactcttgg ttgacccctt ggtgacgtcc catgacaatc ttctcagcaa
    16741 aggttccatc ttcattcaga cgagagttag cctgagctac agtatattca tcttcttcat
    16801 cagctgtcaa ccaaacaatt tcgttcgtga caacacctgt ttcacggtca accttacggt
    16861 atggtgtttg aacaaaacca tatttgttca agtgtccgta agatgacaag ttattgatca
    16921 aaccgatgtt aggtccttca ggtgtctcga ttggacacat acgaccatag tgagtgtagt
    16981 gcacgtcacg tacttcatat ccagcacggt cacgagtcaa accaccaggt cctaaggctg
    17041 acaaacggcg tttgtgagac aactcagaaa gcgggttgtg ttggtccatg aactgtgaca
    17101 actgtgatga accaaagaat tctttaactg cagctgttac aggacggata ttgataattt
    17161 gttgtggtgt caagacttca ttgtcctgaa cagacatacg ttcacggaca ttacgttcca
    17221 tacgagaaag tcccaaacgt acttggttgg caagcaattc accaaccgca cggatacgac
    17281 gatttccaag gtggtcgata tcatctacac ggccaagtcc ttcagccaag ttgaggaagt
    17341 agctcatctc agcaaggata tctgcaggag tcaccgtacg aaccttgtca tctgggttag
    17401 cattaccaat gatcgttacg acgcgatctg gatcagttgg agcaacaacc ttgaattttt
    17461 gaagaacaac aggctcagtc acaacggctg catcgtttgg gatgtagaca atcttgttca
    17521 agtcgccatc caaatggctt tcaatgcttt caatcacgct acgagtcata atcgtaccag
    17581 cttctaccaa gatttctcca gtttcagggt ctaccaatgg ctctgcaatg gtttggttga
    17641 gcaaacgtgt tttaacattg agttttttat tgattttgta acgaccaact gctgccaagt
    17701 catagcgacg tgggtcaaag aagcgagcca caagcaagct acgtgagctt tcagctgtct
    17761 taggctcacc tggacgaagg cgttcgtaaa tttctttcaa ggcttcgtct gtacgagagt
    17821 ccattggatt cttgtggata tctttttcaa cagtgttgcg aaccaattcg ctgtcaccaa
    17881 agatatcaaa gatttcatca tcacctgaga aaccaagagc acgaaccaag gttgtaaatg
    17941 gaatcttacg agtacggtcg atacgagtgt aggtgatatc ttttgagtcg ctttcaagtt
    18001 ccaaccaagc tccacggtta gggataacag ttgaaccata gcccacctta ccatttttgt
    18061 ctactttgtc gttaaagtaa acacctggtg agcggaccaa ctgagaaacg ataatacgtt
    18121 caccaccatt gatgatgaaa gtacccattt ctgtcatgat tgggaaatca ccaaagaaaa
    18181 cttcttgggt cttgatttcg cctgtttctt tattgatcaa acggaaggtt acaaaaattg
    18241 gtgctgagta gctagcatcg tggatacgag cttcttctag cgtgtatttt ggttccttga
    18301 tttcatatcc aacaaattcc aactccattg tgtctgtgaa gtttgaaatt ggcaatacat
    18361 cttcaaacac ttccttaaga ccgtggtcta ggaaagcttt gaatgagtca gtttgaattt
    18421 caatcaaatt tggtaagtca agaacttctt tgattcttga aaaactacga cgggtacgat
    18481 gtttcccgta ttgaacgtca tgtcctgcca agatgattct cctttgtaaa taagttccaa
    18541 gccttgtcaa tcaggctttt ctaatcgcca tatggttgta aaccccttat caccgtgtcc
    18601 tcttgacgaa ttttcagaat ctttaagcct ctgttacaaa tgctcaaaat cttgaaaaaa
    18661 agcacaaaaa gagcagctaa atctgacttt ttcagaagat ttaactgctg tgagccttgt
    18721 ctggacaata tttcagacaa aacctacgac aaatgattac ccatattata ccctatttag
    18781 ctagattttt caaggggttt cagtaggttt ttggtaaatt ttttcccata gaaaacttgg
    18841 catcacattc gaatcacgct atggtacaaa aaactgaaaa aactattgac tgaaaatcat
    18901 tttcaaggta taataataaa cgttaaggcg gtatagccaa gtggtaaggc acggctctgc
    18961 aaaagcttga tcgtcggttc aaatccgtct accgccttct ataacttgat ttatcaggtt
    19021 tcaaatgaac agaaagccca atttgaaggg ctttttttat tttccctcga ataaatacgt
    19081 ataactttaa aaacttttgg agcgagtttg tggcagagtt ctttccatgg cataattccc
    19141 ttttgaaatc aattgaaaaa agcttcgtca cgcctggtga caaaagcctc tagtttattc
    19201 tgtttcttct tctatttcga cttctgtgat ttggactttt accttggtaa cacgtccatt
    19261 cttcacttta tcattggtta agataaactg tttgttttgg ctaaccaatt catagctgag
    19321 tttctcagtc gttggaatag ttcccactcc tgtcaaataa taaccagcga tggtatcaac
    19381 gtcatcactt tccagttcaa catcaaagta attattgaaa tcattgaggg tcatagttcc
    19441 ttgaacaatg taggtatcct cgccaatctg atgaacatct attgctgctt tgtccgtttc
    19501 atcatcaatt tcaccaacaa tttcctctaa gaggtcttcc aaagtcacca aaccagccat
    19561 accaccgtat tcatccagca agattgccat ttgtctttgg gtatttcgca gttcttttag
    19621 caagtcatcc acaaaaatag tttcaggtac aaaaagtgga tcttgcaaaa ttctcttcca
    19681 aacaatattg tcaaaaccgt ccacaaagcc tgccttaagg agactcttgg tgtgaatgat
    19741 tccaattaca ttgtccttat ccccatcata aaccgggata cgagaataat tttgttttaa
    19801 aatactttgg ataatggctt gactatcatc ctgaatatcc accataaagg catccgttcg
    19861 aggaaccata acctctcgtg ccatcagttc atcgagcgaa aagacacctt gtagcatctc
    19921 aatctcatca gcatccaatg tttcttcact atttgtcagc atataggcaa tttcatcacg
    19981 ggtcatcttt tcatccgcat catcgaatga cataggagtc aaatggctca agaaattggt
    20041 cgaagcagct aaaagccaaa caaaaggact gactagtttt ccgatcccaa tgataaccgg
    20101 cgctgtacga attgccaagg catcctttag attaagagcg attctcttag gatataattc
    20161 cccaaaaacg atggaaatat aggtcaaaaa tgccaaggat agaaaagttg ccacggcttg
    20221 tgctgtttcg ccattcccaa gccaagaggc aatcacacgt cctagagtat tagttaaact
    20281 cgcccctgat aagattgtaa tcagggtgat tcctacctga atggttgata aaaagtggtt
    20341 aggattttct agtaccttca gcaggcggat gtagcgtctg tctccttctt ccgccttttg
    20401 ttcaactcgg gcacgattaa gagaaaccat ggccatttct gtggctgaga aaaaggcatt
    20461 taataccgtc aagataaaca ataaaacaaa ttgtagcaac aaattctgac tacttgggtc
    20521 ttccatagtt cttctcctaa aatagtatct tatcctttat tatatcacaa aatttaatcc
    20581 aatacatatt attttttctt accgtaactt ctcaaagtaa cttccatctc tctcccaaaa
    20641 ctggaagtta gttttagaag ttgctatttt ttcttagtac ctgttctagc cctgcttaaa
    20701 ctagtaaaaa gaactcctac atccataagt gacataggag tttaggctta tcttttactg
    20761 agttacagtt acttctccag ttcggtaatc cagttgaagt cccttttgaa cattgggaac
    20821 tagaacattg aattccaatt ctccatccga agacttggct tcaatctgtg aagctgaggg
    20881 aactaaatcc tcgtttgaag cgtagtaaag ggttacacgg taacggacac gcttgttttg
    20941 gtccaaggct ttacgcacct tgctttcata gtagttttga ccagtcgaat actcggcttg
    21001 tgcctgattt gcccaggctg tctgaacagc aatgttttta ggattgcttg ttgaggcatc
    21061 aaaaccatcc aaaccaccga ttaaggcata gcctaacaaa tgacctctat cgactgcatg
    21121 ggtataagag ccctttagat tcttgacctg atgccaacct ggaggagtcc aagaagttga
    21181 accattccca gtttctttac gattcttgta ctgacgagtg gccttagaca agagggcatt
    21241 agctacggtt ggaacagttt ccttgcccac tgtctttgtt ttattgtcag cgtagggctt
    21301 acttgaaacc ttggcatcta gatttgtttt attaccattg acgataaaag cacctgagcc
    21361 attccactcc agactcccct ttatttgact cttgactgcg tctgttaaga cactctctgc
    21421 caatgcttga ctaggagctt cagacgcttg ttttttctga ctaagattgg ttttgggact
    21481 attaggtgcc gacggcatct gcttgatata atagctccct gtagacaaaa gcaataacac
    21541 tagcagtccg attagtgtct gtcttgtttt tttgttcata tttctcctta tctttagaaa
    21601 aaggctggtt ctccagccta atttcctgta aatttatgaa tcaattcctg ccattttgct
    21661 ggagacagga tagcccatgg atcttgaccc ttgcccaaga ttccataacc taccattaga
    21721 ccgattccta gagccagagt acctaaaatc agtactatga tgactaaaag taaacgattg
    21781 attacgtagc ttgatttctt attcatcttc atcgcttgcc tcaatccgct gaatcttagc
    21841 acctagctgc gccaacttct catggaaacc gtagtaacct ctatccaagt gaaccaattt
    21901 accgaccaca gtttctccct gtgctaccaa acctgtcaaa atcaaggctg cactggcacg
    21961 aaggtcagtt gaaagaactt ctgctccctg caaaggctgt ccaccaacaa tacgagctgt
    22021 atcacggata atctcagaat gcaagcccat gcggcgcatc tcttctaggt gttggaaacg
    22081 attttcgaaa actgtctcca ccatggttga ttcgcctttt gcaactgtca tcaaggctgt
    22141 aaattgagcc tgcatatctg ttggaaatcc tgggtggggc aaggttttca catgaacagc
    22201 ttttagattt tccagttgag aacgaacacg aattccttcg tcttcttcaa ttacttcaac
    22261 acccatttca agtaacttgg caatcaaggg acggttgtgc tcccagacag cgtctcgaat
    22321 caagacatca ccaccagtca tggcagcagc taccataaag gttcctgctt cgatacggtc
    22381 ctggactaca ttgtgagtcg taccatgaag tttctcaaca ccagtaatgg ttatagtctc
    22441 tgtaccagca cctttgacct tggctcccat ttcattaagg agaatggcta agtcaacaat
    22501 ctcaggctca cgcgcagcat tctcaatcac tgtcacccca tcagccagag tcgctgccat
    22561 catcaagttc tgcgttgcac caacacttgg aaagtccata tagatatgag caccatgcaa
    22621 gcgttctgcc ttggcttcga tgtaaccagc tgtctgacta atcttaaccc ccatagcttc
    22681 cagacctttc aaatgaagat caataggacg gctaccaatc gtacaaccac ctggcatgga
    22741 taccttggca tgacccacac gggcaaggat tggccctaat acaacgatgg aggcgcgcat
    22801 cttactgaca tacttgtaag gggcttcctc agtgatgtcg ccagtagcat ccaccttgac
    22861 aagatgagct tcctcatcaa agtcaacctt ggcattcaaa ccaccaacta cctgattcat
    22921 aataaagaca tccgacaaaa tcggaacatt ctgcaagacg gtctttcctt cacttgctag
    22981 aatagtcgct gccaacaagg gtaagactgc attttttgct ccctcgatcg tcacgcttcc
    23041 taccagacga ttatcgccac cttgaaccac aattttatcc atactcgttt cctttactct
    23101 tgattttata ataatcctct aagcgcttct tgccacaaat gatacaggct aataaagaaa
    23161 gaactcagga tgtagcctat gacaatgcta aaaaaggcta ctaataaacg aacttttctt
    23221 gtattatcat ctgtcacttt taaaaccttc tcccatctaa caagatcctt taaaaggtaa
    23281 aaactcacat aaataaagag catatgacta cttagagtga ataataattg aaccatttga
    23341 ctattatacc atcttctctg tttgtgcgct agtttggaaa cttcactcaa aaattaggga
    23401 ttgtttttca agtaatcaat cgcatcttgt agggttttaa cgggcacgat tttcatatcc
    23461 gtcttgattg ttttagccgc ttctagggct gtttggtagt tgtttttcgc gtccggatgc
    23521 gccttttgtt cttcttcgct aacagggtta tcaggagtaa agaaaatagc agcacctgcc
    23581 ctagccgaag ctacaacctt cttatcaata cctccaatgt ctcccacatt accatcgcgg
    23641 tcaatggtac ctgtaccggc aacaatacga ccattacgaa gatctgggtg agctatttga
    23701 gtatagatag ctagactaaa catgagacca gcacttgggc cgccaatacc agctgttgaa
    23761 aagctaattg ggacattgct gattacctct gtacggtcaa tcaagccgat tccaattcca
    23821 tttttgccat tttccaaggt gataatcttt ccttctgcag acttggtttg cccatcctct
    23881 tcataggtga ccttgacgga atcccctaat ttttgagaac tgacgtaatc aatcaagtct
    23941 ttggaactat caaaggtctg atcattgact gctgtgactg tatcagagat attgagaatc
    24001 cctttaaagg ttgaattatc cgtcacattc aaaacataaa ctccaaagta cttgagttcg
    24061 atatccttac cagctgtttt tagtccttga tacttggcca tattttgcga tgtttgcatg
    24121 tagaattgat tgattcgcag aaattcaaca tcggaagaac cacctgtagt ctcctgagca
    24181 ctacgaatat ctgtaaaagg tgtcaaccaa gcataaatca tatgagctaa agtggcatgt
    24241 tgaacaccaa ccgtaacgaa ttgataggca ccagcttcct tatcttctgt gtcatttact
    24301 ttaaggactt ggcgaatatc ttccgaacca cctggaacct ctatataata aggcaagggc
    24361 actacaaatg ccaagaaagt cacaatcaag gccgcaatga cgtataaggg ccatctaatc
    24421 ttttttttca tttcttattt cctccaaaat actctcggga acatagcagg caatatcctg
    24481 accaaacttc aaaagctctc taacgcctga tgaactgata tagagatgtt caggtcgact
    24541 atgtaaataa atagtctcta tatcagaaga cagctgatga ttgtagtaat caaaactggc
    24601 ttcatattgc aaatccgacg cattcctcaa gcctcgcact aggcaagtag cccccagtct
    24661 ttttgcgaca tcgaccacca atttatcatg agaagacacg actttaacat ttcccaaatg
    24721 tttcacagcc ttttctaacc cccgtttacg attttcaaga gggagaaatc cttgtttgtg
    24781 gggattaaaa aaaataccca cataaagctt atcaaagagt ctgctcgccc gttcaatgat
    24841 atccagatgc ccatttgtca tcggatcaaa tgagcctgtg aataagccaa tcttatctga
    24901 catagactgt taccttacta attccataaa tcttttcctt ccagataccc agacaggcaa
    24961 tttcttctgg aagttcaacg gccttatccg tctcgcacac aaccataaca tcttcagaaa
    25021 aaagctctct ctcagccatt ttttcaatat ctgctacgat ttgttccttg gcatagggag
    25081 ggtctaagaa aatgaggtca aattccccag atacctgttc caatgccctt tctgcatcca
    25141 tcttgaggag ttgaaatttt ccaacttcct tggtcatctg gatattttca gccacgatgg
    25201 tctgagcctt acggtctcgc tccaccaaaa cagcactgga catgccacgc gatactgctt
    25261 cgatagataa accaccacta cctgcataaa ggtccaagac tcgtccccct tcaaagtagg
    25321 gaccaatcat gttaaaaatg gctcccctaa ccttatccga agtaggtctt gttgtcttgc
    25381 cttctagtgt cttaagggga cgtcccccat agattcctga tatgattttc atactgttta
    25441 ttataccaaa ttatagacaa aaagagaaag aaaaccgaac cttgcggttc gattctctac
    25501 aaaatatttt cgtaagtatc gcggacttct tgaggccaaa cacttgtttg cacttctccg
    25561 atgtgtctct tgcgaagtag gaacatggcc atacgagatt gtccaattcc tccaccgatt
    25621 gtcaatggga ataggccatt caacaaagac ttgtgccatt ccaattccaa gcggtcttca
    25681 tcacctgtaa tttccacctg acgtctaaga gtttcttcat ctacacgaat tcccatagaa
    25741 gacaactcaa aggctccacc taaagactca ttccagacaa gaatatcacc atttagaccc
    25801 ttgtagccat tctcagactc gcttgtccag tcatcatagt ctggtgcacg tccatcgtgc
    25861 ggtttaccat ctggcaactc gccaccgata ccaatcaaaa agacggctcc aaattcttta
    25921 caaatcgcat tttcacgttc tttcggtgtc aagtctgggt agcgttctac caattcttct
    25981 gtatggataa aggtgatttg ttttggcaag atagactcga tgtcatagcg ggcttcaaca
    26041 gctagctcag tcaggcgaat agccttataa atcttctcaa ctgtttcttt tagataaacg
    26101 atgttacgct taccatttgg aataaccttc tcccagtccc actggtcaac ataaacagag
    26161 tgggttgcat ccaaggaatc ctcatctgga cgaagggctt tcatgtggac aaagagaccc
    26221 tctccttcac caaagccaaa acgagccaag gtgtggcgtt tccatttagc aagtgagtgc
    26281 accacttcat aagtagcatc agggatttgg agaaccttga ccgatactgg attttccaca
    26341 ccagacaggt tgtcctgcat tccgtcaccg accttactca agataggacc ttgaacttcg
    26401 acaacttcta gcttatcttt caaatactgg gtaaaagtgt ttttgacaaa ggaaatttct
    26461 tcttgttgat ggataaaact tttcttcata gacaactcct caaaaattta ataaacgtat
    26521 tatacaccta tttccaagaa aagaaaagag aaaatttaaa aaaaatcagt gtcactcaaa
    26581 acactgattt catagacctt ttagtcattg cgaccaaaga tacgtagaat acttaggaaa
    26641 agattgataa aatcaagata gatgctgaga gccattgaca ccacccagcc tgtcgctaca
    26701 cgaccttgtg attgttcata ggcgaggcga atcttttggt tatcccaagc aatcaaccct
    26761 gaaaaaacca aaaccatggc tacgctaatc atataatcaa agaagccact agccaagaaa
    26821 atattgacta ccatagcaat cagtaaacca atgagagctg ccatcattgc tcgaccaatc
    26881 ccactcaagt ctttcttggt aaaaatacca actgccgcca tgacaaagaa gagaagggcg
    26941 ctcgatacaa aggcagataa aactgtaccc ggagtataga aagccaccac aaaactaagg
    27001 gtaaagccgt ttaaaacgga gtaaagtaaa aatactggaa gagcagctgg actatttctt
    27061 gaagccatgc tactggcaac gaaaaccaaa gccaactccg caaaagtagc aatggtcaac
    27121 cagagacgcc cctgcatcaa caagtaaacc aactgagact gaaagaccgt caacataagg
    27181 cctgatacca aagcagatag tccgattccc agaccaacaa aggcataaac cttagcgtaa
    27241 aattgattga gacctgcacg gtcatgtata atagtgtgat tcatcctttt ctccttttct
    27301 gtgaacatct ttccttgatt ataacaaaaa aagttaaaat tagcttaaat ggaagattaa
    27361 aataccggct gcaactgcaa cattcaaact ctcggcctgc cccttcatgc taatatggac
    27421 caactggtct gcactttcag ccataagggg actaattcct tgaccctcat ttcccataac
    27481 tagtacaaaa ttttctatag aaggcagttc tctgtaatca acagaatctt tagatagggt
    27541 tgttgctagc actgggatag ctaccttttt agtttcgtca agaagcgctt gactagtcat
    27601 ccggtaaatg ggcagatgga aatgactacc ttgcatggaa cgtagggttt tgagactgta
    27661 gatgtctgcc gacttatctg aaacaatcac tcctgtaaaa cctgctgcat ccgcagttcg
    27721 aatgatagtt cctacattac caggatcttg cacatcttcc aaaaacaaga acttgccctg
    27781 actcaaatca gcttgtccta cttcttcttt ttgaaccacg gcaacaattc cctgtggagt
    27841 ctgagaatcc gccaaatcta gcaaaatatc ctctgaaatc cagacagttt gcggaaaagc
    27901 agctaactga tttcgataat tttctagggc aaagattttc tcaatcgtca ctccagcttg
    27961 gacagcttct tcaaacaagt gccagccttc aatcaaatag gcagacttgc ggtatttttt
    28021 ttggtgtaat ttcttagcat tttttaccac agaattggct tttgaggtta taatagtcat
    28081 agaaatatta taacacaatc aaaggggttt ggtatgcaaa aggttagaat gattgcccaa
    28141 ggtagggtgc agggagtcgg ctttcgttgg ggtgtttata gcctggccct tgaaatcggt
    28201 ggcatcacag gtcgggtatg gaataacgac gatggcacag tggaaatctt agcccaagca
    28261 gactcatctg ctatcatggc aaaatttatc caagaaatcc gaaaaggacc gacacctttt
    28321 tcaaaagtaa gctacttaga tgtcaaacta agcaactttc ctccctactc tgattttaaa
    28381 atcgcaaatt aggtctccag aactattgta tattttgtaa aaaaacagta gaatagaaag
    28441 gtataatttt taaagaagga ataaaaacag tgaaatctat taaacgtttt gcactctcag
    28501 ctatgggagt ggctatgttg cttgtcttga ctggctgtgt caatgtcgat aaaaccacag
    28561 gtcagccaac aggatttatt tggaatacga tcggagcgcc tatggctgaa gccatcaagt
    28621 acttcgctac tgataaaggt ctaggctttg gtgtcgctat cattatcgta accattatcg
    28681 tacgcttgat tatcttacca cttggtatct accaatcatg gaaggcaacg cttcactctg
    28741 aaaagatgaa cgctctcaag catgtccttg agccacacca aacacgtctc aaagaagcaa
    28801 ctactcaaga agaaaaactc gaagcccaac aagccctctt tgccgctcaa aaagagcacg
    28861 gcatcagcat gtttggtggt gtaggatgtt tccctatcct ccttcaaatg cctttcttct
    28921 ctgctatcta ctttgctgcc caacatactg aaggggttgc tcaagcaagc tacctaggca
    28981 ttcctctagg ttctccaagt atgattttgg ttgcctgtgc tggtgtcctt tactatcttc
    29041 aatcgctcct ttcacttcac ggagtagaag atgaaatgca aagagaacaa atcaagaaaa
    29101 tgatttacat gagcccactc atgatcgtcg tcttctccct cttctcacca gctagtgtca
    29161 cactttactg ggttgtcggt ggtttcatga tgattctcca acagtttatc gtcaactata
    29221 tcgttcgtcc aaaacttcgc aaaaaagtcc gtgaagaact agccaagaac ccaccaaaag
    29281 caagtgcttt ctctaaacca agtggacgaa aagacgttac ccctgaacaa ccaactgcta
    29341 tcacaagcaa gaaaaaacac aaaaatcgca acgctggaaa acaacgttcg agataagaag
    29401 aaaaaggctt agctgatttg ctaagtcttt ttgcaaatca aaagcccgat gtttccatca
    29461 ggtttctttt ctatccatgt acacgtttca tataatcttg ataactttcg gtatccatga
    29521 gttttttagc gttcttgacg cgatctgctg ttggtggttt gactccttcg agggaatatg
    29581 gaattccaag ttcacgccac ttgaactcac ccatggtgtg ataaggtaga atttcaaact
    29641 tatcaacatt tttgagggtc ttgacgaact taccaagttc aatcaagtca tcatctctgt
    29701 ctgtcaatcc tggaactagc acgtggcgaa tccagacagg ttttccaata tctgatagat
    29761 actgggcaca agccaagata tttttattag tttggctagt gacaatcttg tgctgttctt
    29821 cgttgatttc cttgatatcc aaaagaacca agtcagtgac agccatgagt ttgtcaaact
    29881 tctcaaggta acgtggttta ttacggaaag gaagagcaca ggtatccaag gtacagtgga
    29941 ttccttgttc cttagccttg gtgaagagag caatcaggaa atcaatctgc aagagagctt
    30001 ctcctccact gactgtaatc ccacccttat ttccccagaa accacggtag cgcaaggcct
    30061 ctgtcaagac atcatctacc gtccgttcac gtgacttatt ggactccata gcccaagtgt
    30121 ctgggttgtg gcaatactgg caacgcatgt gacagccctg caaaaagaca ataaagcgaa
    30181 taccaggccc atctactgac ccaaagcttt ctgtcgaatg caccattcct gtcacttgtc
    30241 cataatcaat tgtttcttca gacatatcgt taccttcctt gaaaacgttt tatagtttta
    30301 ttatatcacg acttgaagga aaaacaagat ttttgcctat tttttagaaa gcaatctgtt
    30361 tttcaatttc attttcaatc tattatcaga ttattcttca aaatcgaagc catataaggt
    30421 tgcaaaatag tcctcagggc gctctgcacg gcggatttga cgggctttac cttcttcggt
    30481 atagaggatt tccgcagaac gtaatttggc attatactgg tagcccattg aaaatccgtg
    30541 ggcacctgta tcatgaatga ccagcaaatc accgatttct gtatgaggca gttcgcgatt
    30601 gactgcaaat ttatcattgt tttcacagag tgaaccaacc acatctaccg cttcagctgg
    30661 tccatctgga tgggtcacgt tgctaatatg atggtaagct ccgtacatag ctggacgcat
    30721 gaggttgact gctgaggcat ccacacctag ataggtacgg taggtttcct tcttatgagt
    30781 cactcttgtg actagagcac cgtgaggtgc cagcataaaa cgacccaatt cggtgaaaat
    30841 cttgacctga ccaagacctg ctgacgtaag aacttcttca tacaccttac gaactccctc
    30901 accaatcaag gcgatatcgt tcggctcctg gtctggacga taattaacac caataccgcc
    30961 agaaagattg ataaagtcta gccaaatgcc caacttttcc ttgatttcaa cagccagttc
    31021 aaagagctga cgagccaact ctggataata gagatgggtc acggtattgg acgctaggaa
    31081 ggagtgaatc ccaaaagtct tggctccttt ttccttcaag atagcaaagg cttcaaagag
    31141 ctggtccttg gtcatgccaa acttagcctc cccaggattg tccataatgt ctgtccccag
    31201 ttcaaaaacg cctccaggat tataacgaca agagatgatt tctggaatgc ctgctactct
    31261 ctccagatgt tcaatatctt caaaggcatc caagttaatg gtcgcaccca attcacgtgc
    31321 ataggcgtat tccttgtctg acgtgttgtt ggaagagaac ataatctcag aacccagaaa
    31381 gtccagttta tggctcatca aaagctctac ataactagag cagtccacac cacaaccttc
    31441 ttcttggaga attttcaaaa tagctggagt tggagtagcc ttaactgcaa aatattcctt
    31501 aaagcccttg ttccacgaaa aggcttggtt gacggctctt gccttctcac gaatcccctt
    31561 ctcatcatac aagtgaaagg gagtcgggaa ctcggcaaca atcgcttcta actcttctct
    31621 attaataaat ggtgttttca taagcttcct tctattctat ttgaaaagaa aggctgggac
    31681 aatcgttcca acctttagtt ctatctctta tttatcttcg tcaaagatat tgccaacctc
    31741 aacatcgatg gcttggttct tgacatcaat attggttacc ttcaagagtg acttgtagtc
    31801 aaactgcttt tcacgttctt cttgggcatt gtccgcaaag accgctacac ctgccagttc
    31861 tgagtcgaac tcgcgcaaga gactaatcat accgttgacc gttccgccac ctttcaagaa
    31921 gtcatccaca atcaagacac ggctgcctgc cttaagacta cgttttgaaa ggaacatttt
    31981 ctcgatacgg tcaccacttg aacctgaaac atagttgacg ctaacagttg aaccttcggt
    32041 aattttcagg tcacggcgca caatgacaaa agagacattg aggacattgg caactgcatt
    32101 tgcaagtggc acacccttag ttgctacggt cataaccgcg tcaatttttt ggtccataaa
    32161 gcttttggca ataatacgac caatattttt caagatggct ggtgtgctaa gcaaatcaga
    32221 cagatagata taaccacctg gcaagatacg gtcactttct gacaacttgg tacgcaagtc
    32281 ttcaaccatt tccttagcat cctgactcga aatagacggt gtgaagatga cacctccgcc
    32341 agccccagtc actgtctgga tatgaccgat ttcaatttcc tcaaaggcgc gtttgataat
    32401 gacgatatct tctgagatgg atgatttagc agactcatac ttttcagcaa aagtattgag
    32461 actagttagt ttataaggat tattaatcaa atagttggaa atgacaacca tccgatcact
    32521 tcttcttaat ttcatttcta tttcctattc catttttatt caaaaaatca aaaagcaaac
    32581 taaaaagctg gtcgctggtg gttcaaaaca ctgttttgag attgtcgata gaactgacaa
    32641 accctgtaat atacctgcat atatacatac gacaaggcga tactacccta gtttgaagag
    32701 attttcgaag agtattcatt tttgtctttt acttattata ccatattcac ataaaaaaac
    32761 gaacattctt atcctaaaaa atgctcattt ttcttaaatt atcaatctaa atctggttta
    32821 tagaaggaac gattatccat agcgaagatt ttattggtca tctctccttt atccaccaaa
    32881 gccagagctg ttgacatcat catcatgctt gcatccagat tgtcaatcat atggataatc
    32941 tctgcctcca taatacgtgg acggactgga cttccatact caagcaagcc gtggtgactg
    33001 aggatgacat gacgaagcaa aacgacttct tccttggtat catcgatgcc gagttccata
    33061 actgtcttgg taatttcgct atcaatgaga gcgatatgtc caagaagatt acctcgcact
    33121 gtgtactctg tctggtctgg ccccgtcaac tcgataacct tagctaagtc atgcagcata
    33181 atccccgcat agagcaggct cttattgagc tgaggataaa cttcgctaat agcgtctgcc
    33241 aaacgtacca tggtcgccgt atgataagcc aaccccgttt caaaggcatg gtggttggtc
    33301 ttggcagctg gataggagta gaattcctta tcatacttgg tgtagagatt tcggacaatc
    33361 cgttgccaga caggattttc aattttgaaa atcatttgcg acatgtagtc acgaatttcc
    33421 ttgacatcaa ctggtgactt gaccttgaaa tcggctgggt cattgggttc accagcttga
    33481 ggcaggcgga gagtaatttg attgacttga ggggtattgt tataaacttc tcggcgtcct
    33541 ttcatgtgga caaccttacc tgcggtaaag gcctcaatgt tatgaggttg ggcatcccag
    33601 agcttcccat caatctcgcc actatcatct tggaaggtaa aggctaggta gtttttccca
    33661 gctcgagttt gcctcaggtc agctgatttg attaggtaaa agccttcaaa tagctcatct
    33721 tttttcatgt gactaatctt catattcttc ctcattttct tgaaaatgga gtagatcaag
    33781 cgcaggctca ccttctgaca actcaatgtg acggagcgtc cgctcgatag ctatggtacg
    33841 acggtttaat aattcatcaa tattgccaga ggcatgttgg agatgttttt gtgccttgac
    33901 cagaatacca ccaaacttgc caaactcggt cttgacactg gcaagagtct tgctgatatg
    33961 gtcggcactc ttttggatat taagggtctt gaaaccaact gatagggagt taagaagggc
    34021 tgatagggta cttggtcctg caacgataat ctgttcttcc cgtctcaaat catcaaagaa
    34081 gaccggattg cgcacaatct ctgaataaag accttctgtc ggaacaaaca agattccaaa
    34141 attggttgtc cgaggcggtg ctatgtactt gctcttgata tccttggcaa agcgcttgac
    34201 gcttgctagg agtgacttac gacagcgttc aatctcatcc ttgtcacctg tctcataggc
    34261 ttcttccaag cggtaataat ctgccagtgg aaacttagag tcaattggca gatagacgta
    34321 ttcttggtcg ccttgtccgg gtaacttgat ggcatactcc actcgttcac tagagttttc
    34381 aaccgttgcg tattctcgtt cgtactgggc aggtgtcatg atgtcttcaa taatttgccc
    34441 cagttgcaat tctcccagaa tacctcgcgt cttggttcca gagagaacct tgttaagagc
    34501 tccgacatca cgggcaactg tctgcatttc tccaaggcca cgattgacag actccagttg
    34561 tttagaaact gtttcaaagg aagcctgtaa gcgtgtctgc aaggtctttt ctagtttttc
    34621 ctcgaccgtc tggcgcattt gttccaaacg ttgctcattt gattcctgca aggcttggag
    34681 acgttggtct gtcttatctc tagtttggag gagattatct gtcatttctt gacggacttg
    34741 ggtcaggcct tggtgcaatt caatccgcac ttcttgcaaa cggtcgctga cagccacttc
    34801 caaatctttt tggtctaact ggctggcttg tctggcttgg tcaaagcggt aatccaactg
    34861 gtctgacaaa tgatctgcct gatcctccaa gctcttactt aagtgtttct cctgcctatc
    34921 ctgcctttgc caaatcagaa agagaccagc taggttggca attaataata gaataagtaa
    34981 actttccatc ctacctcctg tccttgctat gcagtacgac cacataacca tctgggcaag
    35041 ttaccgacac ttccctatct atatattcgt tagaagcgta cactttttta aagaaaaaat
    35101 tctcctctgt caactcatac ttagctccaa gaatagtcag ctggctatcc cgaactggca
    35161 taaaggctag atagtcgtag tctgaacgag gttctagctg actggtccct tctgaacaat
    35221 aggcaatcaa attttgccca tcctcaattt ctatttgacg catatagggt gccaacttag
    35281 gattgctagg tagaaagaca ttggccaaca tatggtcaat acggccaccc aaggcaccga
    35341 aaatagtgac ctgagcctga ggattttgtt caaagatggt taagagagcc aattccagat
    35401 ctgtatcatc cttttctggt cgggcttgga caaaatactg ggcacgtttt tgaatcacct
    35461 gtcgctcttc ttccgtcaca gaatcaaaat ctccgactgc tagagcaaga ggtaagtctt
    35521 cttccaagac ccagagcgag cctcgatcca ccccaacaaa agcatcaaaa tctgtccgat
    35581 aatgaccgcg gtttccgcct gcaaaaactg caaccctagt ccagttgttt tctgagagtt
    35641 tgtactcgct cattgacttc tcccttaaag acataggaac ctgctacaaa aacagtcgca
    35701 ccagcttctt tggcttgagc aatagtttgg tcatcaatcc caccatccac ttcgatttca
    35761 aagttcaaac ctttttcctc acgaagagca accaactcac gaaccttatc catggtttct
    35821 ggcagaaagg cttgcccacc aaaacctgga ttaaccgtca tgactaaaac ttggtcaact
    35881 agatgaagga cgtgcttgat ggcttcaact ggtgtgccag gattgataac gactgaaggc
    35941 ttaactccga gtgaacgaat tttttggagg gcgccatgaa tatgaggtgt tgcttctaca
    36001 tggatactga tgatgtctgc acctgcacgc gcaaaatctt ccagatgatg ctcagggttt
    36061 gacaccatca agtggcaatc gaaaaccatc ttactatgag gacgaaggct ctcgaccaca
    36121 cctgcaccaa aactgatttg cggtacaaaa tgactgtcca tgatatcgat atgggcatat
    36181 tctgccccag ttgcttctag acgtttgatt tcacgttcaa agttggcata atctgctgcc
    36241 agaattgacg gagcaatctt gtattgagac ataggtttct ccttattttg gaattttttt
    36301 gctgactttt ttataggttt ctctacgatt ttcaatttca ctaaggaatt gcaggtaatt
    36361 gtcaaaacgg aaggttgcaa taacaccctc ttcaacagct ggtttgacgg cacaagacgg
    36421 ctcatgggta tgggtacaag tacggaactt acaatctcgg ctaacagtag caatctctgg
    36481 gaaagcctga ttgaggtctt cagcccttga tacttcatag tccaaggatg aaaatcctgg
    36541 tgtatctgcg attttacccc cgttgagatt gtaaaaacta acagctcgag tggtatggcg
    36601 accgcgacct agactgtctg aaatttctcc cgtttcaaga ttgaggtctg gtgcgatttt
    36661 attgagaaga gttgacttcc caacacctgt ctgccccata aagaccgtaa ccttgcctgt
    36721 taacaaagac aggagttcct ctttactggt cacaaagtca tagccgatgt caccataggt
    36781 ctgctggtaa aaatccagtt ctcccctatc ttccaacaaa tccattttgg aaatatagac
    36841 aatgggatgg atgcccttgt gctccaaaag aaccaagaaa cgatccagca aattgctgtt
    36901 aaaatcaggt tccttgacgg acatgattac tacagcttga tcgatattga caataggcgg
    36961 acgaaccaga ctgtttttcc gttcgtgaat tttgaggata tagccttctg aattttcctc
    37021 ggcagagaaa tctacccagt ccccaacata aggggtatgg ccttttttac ggaaattccc
    37081 acgcgcgcgt gtttgataaa cctggccatc actctccaca tagtagaaac ctgccaaggc
    37141 tttaatgatt tgtccctgca tcttagagtc cttgcccttt aagtgcgtct gctagaccgg
    37201 caaattctgc caagctgaga gcttccccac gcacacttgg tgacaagcct gcctggtcca
    37261 aagccttggt cagcttgtcc ttgacctctt cagtcttacc aaagtaacct gtcaagttat
    37321 tccacaaggt cttgcggcga tgggtaaaac tagccttgga aaccttaaag aaaaagttct
    37381 catcttctac tgctacggct ggctctggac gacgcaccat tttcaagatg gctgaatcca
    37441 catttggtgc tggcacaaag accgtacgag gcacgataaa ggcaaccttg gctgtcatgt
    37501 aatactgcac ggcgatagac aagctaccgt aagccttggt gttaggctgg gctgaaatgc
    37561 ggtccgctac ttctttctgc atcatgacca caaactcaca aaaaggaatg ccactctcaa
    37621 tcaagtgcat gagaataggc gtcgtgatgt agtaaggcaa attagccact accttgattg
    37681 gcaggttagg atttttaaaa ttttggatat gttgcgccaa atcaaccttg agaatatctt
    37741 cgttaactac agtcacatta tcaaaatcac gcagggtatc tgccaaaatt ggcaccaaac
    37801 ggtggtcaat ctcaaaagcc atgacttggg ctgcacgctc agccagaaac tccgtcaagg
    37861 caccaatacc tggcccgatt tcgatgacat tgacctggtc atcaatttca gccgtatcca
    37921 caattttttg aaggatattg gtatccgtca gaaaattttg cccgaaggac tttttaaagg
    37981 taaaaccgtg acgctccagc actgccttgg tcacgctata atctgcaatt ctcatctatt
    38041 ctcttttcta ttatctgtta ctactattgt aacacattcc ccttgtattt tgggaatgaa
    38101 aatcatacca aaaaactatc tttcctcatg aagaaagata gtcttggaaa tctttaaaag
    38161 tggccttaac agttctctcg aaacatgcgt tcatactctt cgaaaatctc ttcaaaccac
    38221 gtcagcttca ccttgccgta ctcaagtaca gcctgcggct agcttcctag tttgctcttt
    38281 gattttcatt gagtatcaaa aaaatcagct tcttgataac ttctattttc gggtagggtc
    38341 aaatccacat cctcctccac atcatccact gtcagttcaa ccgtttgagg taaatttttc
    38401 aaacgataat gcttttgcct ttgcccttca atactagcaa aatcaagcaa atagccatgc
    38461 actaggattt gaaccaaaag gagatgattg gtcatatttt ccatgatgag gatatcttct
    38521 aaaccacctc tggcactagg ataatcagat accctgcgaa tacggatttt ttcacacatg
    38581 agcaagtttc ctcatatcaa tgatttcatc agccttattc cagactaggg gattatgggt
    38641 cgcaatgatg ataattcgat tttcatcttt caaatccacc aagagattca taacctcctc
    38701 tgaattttca ggatcaagag ctgctgttgg ttcatctgcc aaaatcaagg gtggattttt
    38761 caaaatagtc ttagcaaggg caactcgttg ggcctctccc ccagataaag tatagatttt
    38821 ttgttctaaa tccaaatacc ctagattaac tttttctaaa gcccccactt gcttttccaa
    38881 acgttctact tttgagattt tctgaccaac aaaacccaaa tccaaatttt ctttgattga
    38941 ttggttttct aagaggccga aattttgaaa gagatagccc atctggtctc gaaaatactc
    39001 acgagtggga atggttttta aatctttccc ctgatagaga acccttccac catctatctt
    39061 ttctagcttt cccaagatat tcagcagcgt cgtctttccg cttccactct ttccgattaa
    39121 ggcataaacc ttgcccttct ccagcttgag attcaaacca gagaaaatcg cgcggtcatt
    39181 aaatttcttt tccaatcctt gaatatcaat catcttattt tcctttcaat actgccatgc
    39241 taccagcttc ttcttttttg tcctgcctta ctaaaatcaa gagggcgtta agcgtaaaca
    39301 aagctacaac tagagcgcta atcaaaccat ctcttgtcaa aatactagat aggactaggc
    39361 caagcaagag aactcctcct tgcgccagta aatacttgcc atgaagctca tagattgtca
    39421 taccagcaag acgtttaatc ataagctccc gtctgaactg ctcaaaatag agaagattca
    39481 tggaatcaaa taacaagata gccgtagaca gggtcaaaat cgtcccaata aggagagagt
    39541 aaaactctac ccgtttgtca tttagtacct tggcaaaaaa tagctggctt tttaccaagt
    39601 aagaaacctt gtgatacaga ccttgctctt ttagagctgt gatgctgtct ccatatcgat
    39661 ctagtttcaa ggcactatta gccgtagttc cccacaatat ccctgcaaca ggtcttgttc
    39721 cagtcgcttg cggcgttaga actacaataa tcggatcttt taggtactgg cgtgttgtct
    39781 tgtacccatc attatagagg aaacgttcct gtcctgtttc tgtaaaagct agacttacct
    39841 gtgggaggta gtatttctga ctcgtcactt ctacactttc agatgaaaag ttttgcaggt
    39901 aatctgtaaa caatctttgg tagtaggtag actgctctcg caagctctca ggcaagatta
    39961 gcccaaactc tccctcagac aagttttgca tcttgtccat aaactctgaa gaaacggtaa
    40021 tcttttcttc tatcagatag cgtggtgaga catagataac attccctgac ggtgtgtagt
    40081 cactgagacg attgccatct aggtccactt ctgctccatc tgagaaattg tcaacattgc
    40141 tcataatata aaaagagtct gtattggcta accgttcttc agtaaatgtc tgccactcac
    40201 gattatcctt acgcgttcct tcttcatcgg caaatgcact agaccaacca aaggatagac
    40261 ggtaacggtc tgaggactgg ctccatttat tgctagctct ctccatttcc tgcatttcac
    40321 ggtagtgggg taggagagct gtcgcactcg atccgaccac caatacagct aagagttgcc
    40381 ccaccatcat caatgtcatc atacgtttga gagggagttt cccttt
//
LOCUS       DAVHSO010000012        40293 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.012, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000012 DAVHSO010000000
VERSION     DAVHSO010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 40293)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40293)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40293
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.012"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(154..963)
                     /locus_tag="VVR18_000599"
     CDS             complement(154..963)
                     /locus_tag="VVR18_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEU6032175.1"
                     /translation="MQYLEKKEIKEIQLALLDYIDETCKKYDIPYFLSYGTMLGAIRH
                     KGMIPWDDDIDISLYREDYERLLKIIEEENHPRYKVLSYDTSSWYFHNFASILDTSTV
                     IEDHVKYKRHDTSLFIDVFPIDRFTDLSIVDKSYKYVALRQLAYIKKSRAVHGDSKLK
                     DFLRLCSWYALRFVNPRYFYKKIDQLVKNAVTNTPQYEGGVGIGKEGMKEIFPVDTFK
                     ELILTEFEGRMLPVPKKYDQFLTQMYGDYMTPPSKEMQEWYSHSIKAYRKN"
     gene            complement(965..1768)
                     /locus_tag="VVR18_000600"
     CDS             complement(965..1768)
                     /locus_tag="VVR18_000600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEU6032176.1"
                     /translation="MKQLTIEDAKQIELEILDYIDTLCKKHNINYIINYGTLIGAVRH
                     EGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLSLETDKNYFNNFIKITDSTTKI
                     IDTRNTKTYESGIFIDIFPIDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKD
                     WIRTAFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKT
                     IDLPFENLSLPAPEKFDTILTQFYGDYMTLPPEEKRFYSHEFHAYKLED"
     gene            complement(1778..3265)
                     /gene="tacF"
                     /locus_tag="VVR18_000601"
     CDS             complement(1778..3265)
                     /gene="tacF"
                     /locus_tag="VVR18_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV teichoic acid flippase TacF"
                     /protein_id="HEU6032177.1"
                     /translation="MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSV
                     DTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRTFSSLFYLCIACTILTTAVYILA
                     YPLFFIDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIF
                     LFVKNEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVF
                     ANANMLFTFLDRLFLVKTGIDVNVSYYTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGK
                     GDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGILTSLFAFRT
                     IILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVVPEYYLLTTML
                     SETSLLVFYIIFIHRKQLIHLGHIFSYTVRYSLFSLSFVAIYFLINFVYPVDMVINLP
                     FLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKKS"
     gene            3601..4308
                     /locus_tag="VVR18_000602"
     CDS             3601..4308
                     /locus_tag="VVR18_000602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HEU6032178.1"
                     /translation="MIYAGILAGGTGTRMGISNLPKQFLELGDRPILIHTIEKFVLEP
                     SIEKIVVGVHGDWVSHAEDLVDKYLPLYKERIIITKGGADRNTSIKKIIEAIDAYRPL
                     TPEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQFITDIPN
                     RAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIFVIKGKDVALAKGEYSNLK
                     ITTVTDLKIAKSMIEKD"
     gene            4313..5335
                     /locus_tag="VVR18_000603"
     CDS             4313..5335
                     /locus_tag="VVR18_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase catalytic
                     domain-containing protein"
                     /protein_id="HEU6032179.1"
                     /translation="MINQIYQLTKPKFINVKYQEEAIDQENHILIRPNYMAVCHADQR
                     YYQGKRDPKILNKKLPMAMIHESCGTVISDPTGTYEVGQKVVMIPNQSPMQSDEEFYE
                     NYMTGTHFLSSGFDGFMREFVSLPKDRVVAYDAIEDTVAAITEFVSVGMHAMNRLLTL
                     AHSKRERIAVIGDGSLAFVVANIINYTLPESEIVVIGRHWEKLELFSFAKECYITDNI
                     PEELAFDHAFECCGGDGTGPAINDLIRYIRPQGTILMMGVSEYKVNLNTRDALEKGLI
                     LVGSSRSGRIDFKNAIQMMEVKKFANRLKNILYLEEPVREIKDIHRVFATDLNTAFKT
                     VFKWEV"
     gene            5352..6221
                     /gene="licA"
                     /locus_tag="VVR18_000604"
     CDS             5352..6221
                     /gene="licA"
                     /locus_tag="VVR18_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline kinase LicA"
                     /protein_id="HEU6032180.1"
                     /translation="MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIV
                     KFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAAIKVNEYIESAITLDSTSI
                     KTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
                     KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTS
                     QEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRA
                     VKGLASYGGTDEK"
     gene            6211..7089
                     /locus_tag="VVR18_000605"
     CDS             6211..7089
                     /locus_tag="VVR18_000605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HEU6032181.1"
                     /translation="MKSKNGVPFGLLSGIFWGLGLTVSAYIFSIFTDLSPFVVAAAHD
                     FLSIFILLAFLLVKEGKVRLSIFLNIRNVSVIIGALLAGPIGMQANLYAVKYIGSSLA
                     SSVSAIYPAISVLLAFFFLKHKISKNTVFGIVLIIGGIIAQTYKVEQVNSFYIGILCA
                     LVCAIAWGSESVLSSFAMESELSEIEALLIRQVTSFLSYLVIVLFSHQSFTAVANGQL
                     LGLMIVFAAFDMISYLAYYIAINRLQPAKATGLNVSYVVWTVLFAVVFLGAPLDMLTI
                     MTSLVVIAGVYIIIKE"
     gene            7101..7790
                     /locus_tag="VVR18_000606"
     CDS             7101..7790
                     /locus_tag="VVR18_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NTP transferase domain-containing protein"
                     /protein_id="HEU6032182.1"
                     /translation="MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEK
                     GINDIIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDAD
                     NYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFW
                     DAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDY
                     RKLEEILKNEN"
     gene            7886..8734
                     /gene="dprA"
                     /locus_tag="VVR18_000607"
     CDS             7886..8734
                     /gene="dprA"
                     /locus_tag="VVR18_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HEU6032183.1"
                     /translation="MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADIS
                     GCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDCYPWDLSEIYDAPVLLFYKGNLD
                     LLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGMAKGIDTAAHMAALQNGGK
                     TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRG
                     VIVAEAKMRSGSLITCERAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDV
                     LAEFEF"
     gene            9618..10661
                     /locus_tag="VVR18_000608"
     CDS             9618..10661
                     /locus_tag="VVR18_000608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF389 domain-containing protein"
                     /protein_id="HEU6032184.1"
                     /translation="MTNNKLYSLIEFRNKIYEELELSRSDLAILLCAMLIASIGLNMD
                     STPVIIGAMLISPLMTPILGVGLSLAIFDFKLLRKSFKILAIQILASLIASTLYFCLS
                     PISYASSEIVARTSPTIWDVLIAFVGGIAGIIGARKKETNNIVPGVAIATALMPPLCT
                     VGYAIASANPKFIIGSSYLFLINCSFIVIATYIGVRLMMVKKHYFKDNEEDSKMRRIL
                     LLVAVLLMIPSFISATTLVRETLKKESLKKFISEQFQGYNILKKTYSKKTHTLKLTIS
                     GNYLTEEELDMISSKRGDYGLSDVSVQVSQLSDSEQLSKEELVEYFFQYIKDKEAKEK
                     EKANKFDTESEEQ"
     gene            10828..12915
                     /gene="topA"
                     /locus_tag="VVR18_000609"
     CDS             10828..12915
                     /gene="topA"
                     /locus_tag="VVR18_000609"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HEU6032185.1"
                     /translation="MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGH
                     IRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAIS
                     WHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYS
                     ISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHAS
                     FYGVDGKKMKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAAN
                     KINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGS
                     KYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQM
                     TAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGNVVKQVNS
                     KPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTEL
                     GEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEE
                     EMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPS
                     CHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQV
                     VCSKGDYEEEKIK"
     gene            13021..13380
                     /locus_tag="VVR18_000610"
     CDS             13021..13380
                     /locus_tag="VVR18_000610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaN family protein"
                     /protein_id="HEU6032186.1"
                     /translation="MRLIYLIIGFLSLALAIVGVVLPLLPTTPFLLLSIACFSRSSKR
                     FEDWLYHTKLYQTYVADFRETKSITRERKKKIIVSIYVLMGISIYFAPLLPVKIGLGA
                     LTIFITYYLFKVIPDKE"
     gene            13473..14105
                     /locus_tag="VVR18_000611"
     CDS             13473..14105
                     /locus_tag="VVR18_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HEU6032187.1"
                     /translation="MIYEFCAENVTLLEKAMQAGARRIELCDNLAVGGTTPSYGVTKA
                     AVELAANYDTTIMTMIRPRGGDFVYNDLEIAIMLEDIRLTAQAGSQGVVFGTLTADKK
                     LDKPNLEKLIAASKGMEIVFHMAFDELSDEDQLEAIDWLSQAGVTRILTRAGVSGDSL
                     EKRFVHYHRILEYAKGKIEILPGGGIDLENRQTFIDQVGVTQLHGTKVVF"
     gene            14149..14805
                     /locus_tag="VVR18_000612"
     CDS             14149..14805
                     /locus_tag="VVR18_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="HEU6032188.1"
                     /translation="MFEIFKSYQFNQEKAHDYGFIENSEVWTYSCQILQGDFVMTVSI
                     TADNVNFQVFDQETGDLYPHVHMESMRGSFVGNVREACLEILYQIRKACFDVQDFICH
                     QTKRIMTQVQEKYGNQLEYLWEKSPDTAVLRHEGNQKWYAVLMKISWNKLEKGREGQV
                     EAVNLKHDQVANLLSQKGIYPAFHMSKRYWISVSLDDTLSDEEVLELIEKSWNLTSKK
                     "
     gene            14824..15456
                     /locus_tag="VVR18_000613"
     CDS             14824..15456
                     /locus_tag="VVR18_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001010941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-isopropylmalate synthase"
                     /protein_id="HEU6032189.1"
                     /translation="MNFQLAEYSLLKKFSENIGFTTPEECGAIFKYLIENVKTDRQII
                     YSPHCHDDLGMAVANSLAAVKNGAGRVEGTINGIRERAENAALEEIAVALNIRQDYYQ
                     VETSIVLNETINTSEMVSRFSGIPVPKNKAVVGGNTFSHESGIHQDGVLKNPLTYEII
                     TPELVGVKIPLGKLSGRHAFVEKLRELALDFTEEDIKPLFAKFKALADKK"
     gene            15484..15918
                     /locus_tag="VVR18_000614"
     CDS             15484..15918
                     /locus_tag="VVR18_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase I"
                     /protein_id="HEU6032190.1"
                     /translation="MVAGTMVENPEGFHFDDLQLQTHADNDIEALVSLANMDGEKVEF
                     NATGQGSVEAIFNAIDKFFNQSVRLVSYTIDAVTDGIDTQDRVLVTVENRDTETIFNA
                     AGLDFDVLKASAIVYINANTFVQKENAGEMGRSVSYHDMPSV"
     gene            15930..16967
                     /gene="leuB"
                     /locus_tag="VVR18_000615"
     CDS             15930..16967
                     /gene="leuB"
                     /locus_tag="VVR18_000615"
                     /EC_number="1.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="HEU6032191.1"
                     /translation="MAKKIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFG
                     GADIDAAGPPLPDETLKASREADAILLAAIGSPQYDGAVVRPEQGLMALRKELNLYAN
                     IRPVKIFDSLKHLSPLKLERIAGVDFVVVRELTGGIYFGDHILEERNARDINDYSYEE
                     VERIIRKAFEIARNRRKILTSIDKQNVLATSKLWRKVAEEVAQDFPDVTLEHQLVDSA
                     AMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLEVMPSASHSENGPSLYEPIHGSA
                     PDIAGQGIANPTSMILSVAMMLRDSFGRYEDAERIKRAVETSLAAGILTRDIGGQAST
                     KEMTEAIIARL"
     gene            16964..17233
                     /locus_tag="VVR18_000616"
     CDS             16964..17233
                     /locus_tag="VVR18_000616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HEU6032192.1"
                     /translation="MKLDEKITLVLLIWNVIIFLIYGIDKFKARRRAWRIPEKILLIL
                     ALTCGGFGAWLAGITFHHKTRKWYFKTVWFLGMVTTLVALYFIWR"
     gene            17237..17596
                     /gene="leuD"
                     /locus_tag="VVR18_000617"
     CDS             17237..17596
                     /gene="leuD"
                     /locus_tag="VVR18_000617"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HEU6032193.1"
                     /translation="MAGSSREHAAWALADYGFKVVIAGSFGDIHYNNELNNGLLPIVQ
                     PREVREKLAQLKPTDQVTVDLEQQKIISPVEEFTFEIDSEWKHKLLNSLDDIGITLQY
                     EELIAAYEKQRPAYWQD"
     gene            17758..18382
                     /locus_tag="VVR18_000618"
                     /pseudo
     CDS             17758..18382
                     /locus_tag="VVR18_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002276310.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="translation factor (SUA5)"
     gene            18545..20476
                     /locus_tag="VVR18_000619"
     CDS             18545..20476
                     /locus_tag="VVR18_000619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrB family protein"
                     /protein_id="HEU6032194.1"
                     /translation="MNKRKVSLEDFYKWYSLNKEELLNKATVGEKFNDKLKEEFLQEW
                     PLDRILTMSIDEYVIGKGQQNKSLCYALEKGKYKNLFLGISGGSASKFGIYWNKKTNK
                     YKDQANNEISELDQRFSKLKSDLYEIIKEGIRFNFENPIFDMKRSTNEFIGRSAMVTK
                     LLCIYSEGDPFFGVNINSQKEFWNHFVSQTNQGGPYLQNHKIIELVSKTYPELEPSKV
                     GTMLFEYSKLFMENKEDNSTMDSSNNFRHQLTQSLLKSPNLILRGAPGTGKTYLAKEI
                     AKELTDGNEDQIGFVQFHPSYDYTDFVEGLRPVSNGDGAIEFRLQDGIFKDFCQKAKE
                     TQLIGGQDNFDEAWDSYLEYINVAEEKEYITKTSYLSVNSRQNLSVNYDSGVPGWSLP
                     SKYVYELYKDKNYNKQEYYKSGGKTVLETLRKRFGLKDYVSPTEIDTDKKFVFIIDEI
                     NRGEISKIFGELFFSIDPGYRGEKGSVSTQYANLHETDEKFYIPENVYIIGTMNDIDR
                     SVDTFDFAMRRRFRFVEVTAEGQVGMLGKELNIHAEEAKIRLRNLNAAIENVQELNSH
                     YHIGPSYFLKLKDVDFDYELLWSDYIKPLLEDYLRGSYDEVETLETLKKAFELTNNEQ
                     KDQAVADDNEGDENDDADY"
     gene            20463..21779
                     /locus_tag="VVR18_000620"
     CDS             20463..21779
                     /locus_tag="VVR18_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001223073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HEU6032195.1"
                     /translation="MRITDNQHKIIKEKFVEEYPKLSNLLLDRTLESLSQDERIFIFP
                     NDLTHTPDLDKDQKIFETVNQKIKTGNVIGFLGYGQERLTISSRFSDESNDHFLHYLL
                     NKVLHINLTSLDVALSREERLYQLLVYLFPKYLQAAIRKGLYKEYHRFSHNDSHVKGV
                     IDVRSHLKKNLPFTGNIAYATREFTYDNPLMQLVRHTIEYIKNQKSIGQGVLDNLSTS
                     RENVSEIVRVTPSYKLADRAKIIRGNQSKPIRHAYFHEYRNLQELCLMILNQEKHGLG
                     YQDQKIYGILFDVAWLWEEYVYTLLPKGFVHPRNKDKTDGISVFSVGKRKVYPDFYDR
                     ERKIVLDAKYKKLELTEKGINREDLFQLISYSYILKAEKAGLIFPSMEQSVNSEIGKV
                     AGYGAQLKKWSIRIPQNASFYSTFCKMMENSEENFKAIIDEEVGRK"
     gene            21954..22940
                     /locus_tag="VVR18_000621"
     CDS             21954..22940
                     /locus_tag="VVR18_000621"
                     /EC_number="1.7.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GMP reductase"
                     /protein_id="HEU6032196.1"
                     /translation="MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVV
                     PANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEY
                     DFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
                     AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIA
                     KSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRIL
                     LPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH"
     gene            23004..23075
                     /locus_tag="VVR18_000622"
     tRNA            23004..23075
                     /locus_tag="VVR18_000622"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:23037..23039,aa:Arg,seq:ccg)
     gene            23258..23956
                     /locus_tag="VVR18_000623"
     CDS             23258..23956
                     /locus_tag="VVR18_000623"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HEU6032197.1"
                     /translation="MKELQTVLKNHFAIEFTDKKLLETAFTHTSYANEHRLLKISHNE
                     RLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKL
                     GKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
                     YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQE
                     AAKNAVEKGLDSCI"
     gene            23947..27486
                     /gene="smc"
                     /locus_tag="VVR18_000624"
     CDS             23947..27486
                     /gene="smc"
                     /locus_tag="VVR18_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HEU6032198.1"
                     /translation="MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESL
                     RWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVER
                     HIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKPEERRSI
                     FEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENARKFLDL
                     EGQRKAIYLDVLVAQIKENKAELESTEEELAQVQELLMSYYQKREKLEEENQTLKKQR
                     QDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEVQARLAALEDKRNS
                     LSKEKSDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEE
                     ADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLAIAKEKASQQKEELETAKEQVQK
                     LLADYQAIAKEQEEQKTSYQAQQSQLFDRLDNLKNKQARAQSLENILRNHSNFYAGVK
                     SVLQEKDRLGGIIGAVSEHLTFDMHYQTALEIALGASSQHIIVEDENAATKAIDFLKR
                     NRAGRATFLPLTTIKARTISSQNQDAIAVSPGFLGMADELVTFDTRLEAIFKNLLATT
                     AIFDTVEHAREAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIFIKPELEQLQK
                     EIAEEEASLDSEEVALKTLQDEMARLIESLEAIKSQGEQARIQEQGLFLAYQQTSQQV
                     EELETLWKLQEKELNRLSDGDWQADKEKCQERLATIASDKQNLEAEIEEIKSNKNAIQ
                     ERYQNLQEELAQARLLKTELQGQKRYEVADIERLGKELDNLNIEQEEIQRMLQEKVDN
                     LEKVDTELLSQQAEESKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEW
                     IRKQTRAEAKKEKVSERLRHLQSQLTDQYQISYTEALEKAHELENLNLAEQEVKDLEK
                     AIRSLGPVNIEAIDQYEEVHNRLDFLNSQRDDILSAKNLLLETITEMNDEVKERFKST
                     FEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKA
                     LSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGT
                     MAAADSIYGVTMQESGVSKIVSVKLKDLESIEG"
     gene            27483..28277
                     /locus_tag="VVR18_000625"
     CDS             27483..28277
                     /locus_tag="VVR18_000625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU6032199.1"
                     /translation="MTIKLVATDMDGTFLDGNGRFDMDRLKSLLASYKEKGIYFAVAS
                     GRGFLSLEKLFAGVRDDIIFIAENGSLVEYQGQDLYEATMSRDFYLATFEKLKTSPYV
                     DINKLLLTGKKGSYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEET
                     LEAGEAWVNDNVPGVKAMTTGFESIDIVLDYVDKGVAIVELAKKLGITMDQVMAFGDN
                     LNDLHMMQVVGHPVAPENARPEILELAKTVIGHHKERSVIAYMEGL"
     gene            28277..29095
                     /locus_tag="VVR18_000626"
     CDS             28277..29095
                     /locus_tag="VVR18_000626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU6032200.1"
                     /translation="MADIKLIALDLDGTLLTTDKRLTDRTKETLKAARDRGIKVVLTT
                     GRPLKAMDFFLHELGTDGQEDEYTITFNGGLVQKNTGEILDKTVFSYDDVARLYEETE
                     KLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFAQE
                     PLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGIDQSQVMACG
                     DEANDLSMIEWAGLGVAMQNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKEN"
     gene            29099..30376
                     /gene="ftsY"
                     /locus_tag="VVR18_000627"
     CDS             29099..30376
                     /gene="ftsY"
                     /locus_tag="VVR18_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HEU6032201.1"
                     /translation="MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVNPTFTEVEEVS
                     QEEAEVEIVEQAVFQEEEIQDTVEESLDLEPVIEVSQKEVKEFPHSEEGNTEFLETVE
                     ENNSEILEAERPQTEETVQEKYDRSLKKTRTGFGARLNAFFANFRSVDEEFFEELEEL
                     LIMSDVGVQVASNLTEELRYEAKLENAKKPDALRRVIIEKLVELYEKDGSYDESIHFQ
                     DNLTVMLFVGVNGVGKTTSIGKLAHRYKRAGKKVMLVAADTFRAGAVAQLAEWGRRVD
                     VPVVTGPEKADPASVVFDGMERAVAEGIDILMIDTAGRLQNKDNLMAELEKIGRIIKR
                     VVPEAPHETFLALDASTGQNALVQAKEFSKITPLTGIVLTKIDGTARGGVVLAIREEL
                     NIPVKLIGFGEKIDDIGEFNSENFMKGLLEGLI"
     gene            complement(30420..31907)
                     /locus_tag="VVR18_000628"
     CDS             complement(30420..31907)
                     /locus_tag="VVR18_000628"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="HEU6032202.1"
                     /translation="MSSKVIVTIFGASGDLAKRKLYPSLFRLYQSGNLSKHFAVIGTA
                     RRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELN
                     EKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDDKGFERLIVEKPFGTDYATASKLN
                     DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLG
                     VEERGGYYDQSGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTD
                     EELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAFFVDSDRFRSVPFF
                     FRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFN
                     LAPNSLDYRTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEKLWA
                     ENGVPLHDYKAGSMGPQASFDLLEKFGAKWTWQPDIAYRQDGRLE"
     gene            complement(32056..32796)
                     /locus_tag="VVR18_000629"
     CDS             complement(32056..32796)
                     /locus_tag="VVR18_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU6032203.1"
                     /translation="MAKLKIDVNDLHKHYGKNEVLKGITTKFYEGDVVCIIGPSGSGK
                     STFLRSLNLLEEVTSGHITVNGYDLTEKTTNVDHVRENIGMVFQHFNLFPHMSVLDNI
                     TFAPIEHKLMTKEEAEKLGMELLEKVGLADKANANPDSLSGGQKQRVAIARGLAMNPD
                     IMLFDEPTSALDPEMVGDVLNVMKELAEQGMTMIIVTHEMGFARQVANRVIFTADGEF
                     LEDGTPDQIFDNPQHPRLKEFLDKVLNV"
     gene            complement(32796..34961)
                     /locus_tag="VVR18_000630"
     CDS             complement(32796..34961)
                     /locus_tag="VVR18_000630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEU6032204.1"
                     /translation="MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQ
                     TYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFT
                     MSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFD
                     TGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEH
                     LVTEFNQALSEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSS
                     FAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGM
                     SVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQ
                     SKYGYKIKTFADGSSMYDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETA
                     FAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQ
                     NNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPL
                     MILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQ
                     MEASRSLGISYGKTMRKIILPQATKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGK
                     IIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIR"
     gene            35133..36086
                     /locus_tag="VVR18_000631"
     CDS             35133..36086
                     /locus_tag="VVR18_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6032205.1"
                     /translation="MKNKRIFKDFQASKMNLNIYTSPLLAFVFVFIGEFVAYTLYGIS
                     LLALIGLARNFGEAGQNLASYLQTLHQSLMDKTSDFRLILGLLAFGFILNTVFRWTRK
                     VEKRPIRTLGFYRENFLSNLLKGFSLGLALFLLTLLGLVVLDQYRLESIHLNPYSLAF
                     VVFTIPFWILQGTAEEVVARAWLLPQLASRTNLKLAILISSLFFTLLHMGNSGLTPLS
                     LVNLFLFGVTMALYLLKTDTVWGVAGIHGAWNFAQGNLFGILVSGQPSGTSLMTFLPQ
                     GNQDWLSGGSFGIEGSIMTSLVLLLLIVYLANKLKKENERM"
     gene            36163..38151
                     /gene="uvrB"
                     /locus_tag="VVR18_000632"
     CDS             36163..38151
                     /gene="uvrB"
                     /locus_tag="VVR18_000632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit B"
                     /protein_id="HEU6032206.1"
                     /translation="MINHITDNQFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMG
                     ATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQ
                     PEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYA
                     DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFR
                     VEFFGDEIDRIREVEALTGQVLGEVDHLAIFPATHFVTNDDHMEVAVAKIQAELEEQL
                     AVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPYTLLDFF
                     PDDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVH
                     QIVYVSATPGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKN
                     ERTFITTLTKKMAEDLTDYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGIN
                     LLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADTVTQSMQ
                     RAIDETARRRKIQMAYNEEHGIVPQTIKKEIRDLIAVTKAVAKEEDKEVDINSLNKQE
                     RKELVKKLEKQMQEAVEVLDFELAAQIRDMMLEVKALD"
     gene            38161..38724
                     /locus_tag="VVR18_000633"
     CDS             38161..38724
                     /locus_tag="VVR18_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032207.1"
                     /translation="MIYLRKLKREDLMSLWEMAYSQLNPVWKQYDAPYYDDYQYFSNF
                     KEFELQKSESILSNSNRLGIFVDDKLVGTVSRYWVCKQTRWMELGIGIYDKKFWNTGI
                     GKVAMLQWIDRTFQDYLELEHLGLTTWSGNLGMMKLAEKLRMKKEAHIPKVRYYQGKY
                     FDSIKYGILREDWEKINDGYYKINGNS"
     gene            38690..39199
                     /locus_tag="VVR18_000634"
     CDS             38690..39199
                     /locus_tag="VVR18_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000216007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032208.1"
                     /translation="MTVIIKSMETPEEIEGKSLVHWQTWREAYDDLLPAEFQETMTLE
                     RCRFFSQKYPENTLIAIDDVKVVGFISYGNFRDETIQAGEIIALYVLKDYYGKGIAQK
                     LMKAALTALNHFSEIFLWVLKDNKRAIAFYQKMGFTFDGQEKILELGKPIKEKRMVFY
                     SKIILKSRS"
     gene            39252..39716
                     /locus_tag="VVR18_000635"
                     /pseudo
     CDS             39252..39716
                     /locus_tag="VVR18_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091533.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
BASE COUNT        12548 a         7028 c         8740 g        11977 t
ORIGIN      
        1 aaaaaagtct ttaaaattat aaaacgcatc atatcaagat ttttcaaaaa ccttgatatg
       61 atgcgtttta ttgtgggaat atgtatttca ttttctacta aaattatgtt tttgaataac
      121 ctctatctta gtagtttgta taatccccct caatcagttt ttgcgataag ctttaatgct
      181 atgactatac cactcttgca tttcttttga tggtggtgtc atataatcgc catacatctg
      241 ggttaaaaat tggtcatatt ttttgggaac aggcaacata cggccctcaa actcagttaa
      301 aatcagttct ttaaaggtat caactgggaa gatttctttc atcccttcct taccgatccc
      361 aactcctcct tcatattgag gagtgttggt tacagcattt ttgactagtt gatcaatttt
      421 cttgtaaaag tagcgaggat tgacaaatcg gagagcgtac cagctacata atctaagaaa
      481 atcttttagt ttgctatcac cgtgaactgc tcgtgatttt ttgatataag ctagttgacg
      541 aagagccaca tacttatagc tcttgtcgac aatgctcaag tctgtaaatc gatcaattgg
      601 gaagacatcg atgaaaaggc tggtatcatg acgcttgtac ttaacatggt cttctataac
      661 agtagaagtg tccaaaatcg atgcgaaatt atggaagtac caagaagatg tatcgtagga
      721 aagaaccttg tagcgagggt gattttcttc ttcaataatc ttcagtaaac gctcataatc
      781 ctcacgataa agggaaatat caatatcatc atcccaagga atcatacctt tgtggcggat
      841 ggctccaagc atggttccat aactgagaaa ataaggaata tcatatttct tacaagtctc
      901 atcaatatag tccagcaggg ctagttgaat ttctttaatt tctttttttt ctaaatattg
      961 catcctaatc ctccaattta taagcgtgaa attcatgact gtagaagcgt ttttcttctg
     1021 gtggtagggt catataatct ccataaaatt gtgtcaaaat agtatcaaat ttttcaggtg
     1081 caggaaggct taaattctca aagggtaaat cgattgtttt atcaaaggta ccacttggga
     1141 agacttcctt ttccttaaat tttgaaggga taaaagccat atattgccca ttttcacgac
     1201 tatatttttg aatttctttc tcgattttat ttgcaaaata acgaggagaa accggtcgaa
     1261 ggagtaacca gaaggctgtt cgtatccaat cttttaaaag gctatcctta tagacaatat
     1321 ttttatgttt actgaaagac agcagtttga agctttccag tttataacaa gtatcaatga
     1381 ccttaggatc atcaaagcga tctataggga aaatatcgat aaagatacca gactcatagg
     1441 tttttgtatt tcgagtatca ataattttag tcgtactgtc ggttatcttg ataaagttgt
     1501 taaagtagtt cttatcagtt tctaaggata ggagcttata cttgcttttt tccttttgaa
     1561 aaatgttaat aaatcgttgg tagtcttctc taggcatgga taaatcaata tcgtcgtccc
     1621 aagggataaa gccctcatgt cgaaccgccc caatcagagt accgtagtta ataatatagt
     1681 tgatattgtg ctttttacag agagtatcaa tataatccaa aatttctaat tcaatttgtt
     1741 tggcatcttc aatggttagt tgtttcattt taaactccta tgattttttg aatttatttt
     1801 ttaaggctag gacatggttt aaaaattcat agaaaatgct atcttttgtg aagacaagta
     1861 gactaatata agagatagct gatagcaaga caatcaaacc agtattaatt aaaaatggca
     1921 aattaatgac catatccaca ggatacacga aattaatcag gaaataaatt gctacaaagg
     1981 aaagtgaaaa gagagagtat cgaacagtat agctaaagat atgtcccaag tggatgagtt
     2041 gttttctatg gatgaaaata atatagaaaa caagtagaga agtctctgat aacatagttg
     2101 tcagtaagta gtattcagga accacgatat ggttgaaaaa gaggagacta ttcaagccca
     2161 aattgagtag cccagcaaag actgtataga ctgtgatacg tttttcatag ccattggtaa
     2221 agagaatttg ggaaccaaga atggtatcta aggccaggat aatcgtacga aaagcgaaga
     2281 gagaggtcaa gatgccgcct ccgatatatt tttcactacc gtaaagtagg atggcatttg
     2341 gtcctaaaac catgagtcca aaactcagtg gaatgataaa gaagttaaag attcgactac
     2401 ctctattaac cagagaaaca taggcttctt tgtctccttt ccccagatag taactgagac
     2461 gaggcacact cactccaatt gcacctgtta caaccccagc tataacggtc acaattcgct
     2521 gagctatggt atagtaacta acgttgacat caatccctgt tttaacgagg aagaggcgat
     2581 ctaaaaaagt gaagagcata ttggcattgg caaagactaa catggctgtc agagggagaa
     2641 agagtggttt aaaatcactt aggtgaatct taacaagttt gatgtctctt ttaatccaaa
     2701 aataactaat caggtagtta atcagcgtcg ataaactcat cacaagtgta tagacaacaa
     2761 tatcgtgttc atttttaaca aataagaaaa tagagaccag catcaggata cggatgaagg
     2821 cagttttgta aaagagaaaa ctgtaatttt ccagagcttc attgacccat tcgattgaaa
     2881 aaatctgggc aatgagttga atccccataa caaggtagac ctttttgacg attggattat
     2941 caataaagaa gagaggatag gctaggatat agacagcagt ggtcaaaatc gtacaagcga
     3001 tgcacaaata aaaaagacta gaaaaggttc tgttaagatc ttttttgtta tccttgacat
     3061 tactgatagc ccttaaaccg tagttataga caccataagt tgcaaagggc aagaaaaatg
     3121 acaaaatagt gtcgactgag ttgaagtaac catagtcagt tcggtccaag acacgcgcga
     3181 cataggttcc agttaggatg ggaaaaataa tattcaagac acgaattccc atgtaagata
     3241 gagcatttaa ttttatactt ttcattcaat ttacctcgtt tttcattata tcataaagtt
     3301 agctaataag aaatgaaggg cagtaagtca agtaatcact ttgaagtttc aaatcttaag
     3361 ttttaagttt tctttaagga aagtatatta ttctgaagga ctctaaaatt tcgcagccat
     3421 ttattagtaa ttgctacaga attcctagtc attactagaa atggactagt ttctttgaat
     3481 aatagaactg cataattctc ctattctaga aggggaggac cagtatttct tttatgatag
     3541 gactagattg tggtataata gagagaataa gtttttttag taagacaaag gagaaaatag
     3601 atgatttatg caggaattct tgccggtgga actggcacac gcatggggat cagtaacttg
     3661 ccaaaacaat ttttagagct aggtgatcga cctattttga ttcatacaat tgaaaaattt
     3721 gtcttggagc caagtattga aaaaattgta gttggtgttc atggagactg ggtttctcat
     3781 gcagaagatc ttgtagataa atatcttcct ctttataagg aacgtatcat cattacaaag
     3841 ggtggtgctg accgcaatac aagtattaag aaaatcattg aagccattga tgcttatcgt
     3901 ccgcttactc cagaggatat cgttgttacc cacgattctg ttcgtccatt tattacactt
     3961 cgcatgattc aggacaatat ccaacttgcc caaaatcatg acgcagtgga cacagtggta
     4021 gaagcagttg atactatcgt tgaaagtacc aatggtcaat ttattacaga tattccaaat
     4081 cgtgctcacc tttatcaagg acaaacacct caaacattcc gttgcaagga cttcatggac
     4141 ctttatggat ctctttctga tgaagagaag gaaatcttga cagatgcatg taaaatcttt
     4201 gtgatcaaag gaaaagatgt ggccttggcc aaaggtgaat actcaaatct gaagattaca
     4261 accgtaacag atttgaagat tgcaaaaagt atgattgaga aagactagta aaatgattaa
     4321 tcaaatttat caactaacta agcctaagtt tatcaatgtc aaatatcagg aagaggctat
     4381 tgaccaagag aatcatatcc ttatccgtcc caactacatg gctgtctgtc atgcggatca
     4441 gcgttactat cagggaaaac gtgatcccaa gattttgaat aaaaagcttc caatggcaat
     4501 gattcacgag tcatgtggaa ccgtcatttc tgacccgacc ggaacctacg aggttggtca
     4561 aaaagttgtc atgattccca atcagtctcc tatgcagagt gatgaagaat tctatgaaaa
     4621 ctacatgaca gggacccatt tcttgtctag tggatttgat ggctttatga gagagtttgt
     4681 ttctctccct aaagatcgtg tggtggctta tgatgctatt gaagatacgg ttgcagccat
     4741 tacagagttt gtcagtgtgg gcatgcacgc tatgaatcgt ctattgactc ttgctcatag
     4801 caagcgggag cggatcgccg ttattggaga tggaagttta gcttttgtgg ttgccaatat
     4861 tatcaactat actttgccag aatcagagat tgtggttatt ggtcgtcatt gggaaaagtt
     4921 ggaactcttc tcatttgcca aagaatgcta tattacggat aatattcctg aagagttggc
     4981 ctttgaccat gcttttgaat gttgtggtgg tgatggtact ggaccagcta ttaatgactt
     5041 gattcgctac attcgtcctc agggaacgat tctcatgatg ggagttagcg aatataaagt
     5101 caatctcaat actcgcgatg ccttagaaaa gggcttgatt ttggttgggt catctcgttc
     5161 tggtcgcatt gattttaaaa atgctatcca aatgatggaa gtcaagaaat ttgccaatcg
     5221 tcttaaaaat atcctttatc tagaagaacc tgtaagagaa attaaagata ttcatcgtgt
     5281 ctttgcaacc gatttaaaca cagcctttaa aacagtgttt aagtgggaag tataagtact
     5341 ggaggttaat tgtggagaaa atcattaaag aaaaaatttc ttccttactt agtcaagaag
     5401 aggaagtcct cagtgttgaa caactgggtg gaatgaccaa tcaaaactat ttggccaaaa
     5461 caacaaataa gcaatacatt gttaaattct ttggtaaagg gacagaaaag cttatcaatc
     5521 gacaagatga aaagtacaat cttgaactac taaaggattt aggcttagat gtaaaaaatt
     5581 atctttttga tattgaagct gctatcaaag taaatgagta tatcgaatct gcgattacgc
     5641 ttgattcaac gtcaatcaag accaagttcg acaaaattgc tccaatatta caaactattc
     5701 atacgtctgc taaggaatta agaggagaat ttgctccttt tgaagaaatc aaaaaatacg
     5761 aatccttgat tgaagaacaa attccttatg ccaactatga atctgttaga aatgcagtct
     5821 tctccttaga gaaaagactg gctgacttag gtgttgacag aaaatcttgt catatcgatt
     5881 tggtgcctga aaactttatc gaatcacctc aaggacgact ttatttgatt gactgggaat
     5941 attcatcaat gaatgatcca atgtgggatt tggctgccct ctttttagag tctgaattca
     6001 cttcccaaga ggaagaaact ttcttatctc actatgagag tgaccaaaca ccggtttctc
     6061 atgaaaagat tgctatttat aaaattttac aagatactat ttggagtcta tggactgtct
     6121 ataaggaaga gcaaggtgaa gattttggtg actatggtgt gaatcgttac caaagagctg
     6181 ttaaaggttt ggcttcttat ggaggaacag atgaaaagta aaaacggagt tccttttggc
     6241 cttctctcag gtattttctg gggcttgggt ctaacggtta gtgcttatat cttttcgatt
     6301 tttacagatt tgtcaccctt tgtggtggct gcagctcatg attttttgag catctttatc
     6361 ttactagctt ttctcttggt aaaagaaggg aaagttcgcc tctcaatttt cttaaatatt
     6421 cgcaatgtca gtgttatcat cggagccttg ctagcaggcc ctatcggtat gcaggccaat
     6481 ctttatgcag ttaagtatat cggaagttct ttagcttcat ctgtatcggc tatttaccct
     6541 gcgatttcag ttctattggc tttcttcttt ttgaagcaca aaatttcgaa aaatactgta
     6601 tttgggattg tcttgattat tggagggatt attgcccaga cctataaggt tgaacaggtt
     6661 aattccttct acattgggat tctctgtgct ttggtttgtg ctattgcatg gggaagtgag
     6721 agtgttctta gctcctttgc tatggaaagt gaactgagtg aaatcgaagc cctcttaatc
     6781 cgtcaagtga cttcgttctt gtcctatctt gtgattgtgc tcttctctca tcagtcattt
     6841 actgcagtag ccaatggaca attgctaggt ctcatgattg tttttgcagc ctttgatatg
     6901 atttcctact tggcttatta tatcgctatc aatcgcttgc aaccagccaa ggctacaggc
     6961 ttgaacgtga gctatgtagt atggacggtc ttgtttgcag ttgttttctt gggtgcaccg
     7021 ctagatatgc tgaccattat gacgtcactt gtcgtcattg ctggagttta tattattatt
     7081 aaagaataaa ggagattcgt gtgaaagcca ttatcttagc agcgggattg ggaactcgct
     7141 tgcgtcctat gactgaaaat acccctaaag ccttggttca ggttaatcaa aaacctttga
     7201 ttgaatacca aattgagttt ctcaaagaaa aaggaatcaa tgacatcatc atcatcgttg
     7261 gttatcttaa agaacaattc gattatttaa aagaaaaata cggtgttcgc ctcgttttca
     7321 atgataaata cgctgactac aataactttt actctctcta tcttgtaaaa gaagaattgg
     7381 ccaacagcta tgttattgat gctgacaatt atctctttaa aaatatgttc cgcaatgatt
     7441 tgacacgttc gacttatttt agtgtttatc gtgaagattg taccaacgaa tggttcttgg
     7501 tctatggaga tgactacaag gttcaagaca ttattgttga tagcaaggca ggtcgcatcc
     7561 ttagtggtgt atccttctgg gatgctccaa ctgcagaaaa gattgtcagc tttatcgaca
     7621 aggcttatgc aagtggcgaa tttgttgatc tctactggga caatatggtt aaggataata
     7681 tcaaagagct agatgtctat gttgaagaat tagaaggcaa tagcatttat gagatcgata
     7741 gtgtccaaga ctatcgtaaa ttagaagaaa ttcttaaaaa cgaaaattaa agattccaac
     7801 atctgacaaa atagtcggat gttttttgat tttttacgaa cttttacgaa tagatagatg
     7861 agtagaaaaa gaaatggagt tatttatgaa aatcacaaac tatgaaatct ataagttaaa
     7921 aaaatcaggt ttgaccaatc aacagatttt gaaagtgcta gaatacggtg aaaatgttga
     7981 tcaggagctt ttattgggtg atattgcaga tatctcaggt tgccgtaatc cagccgtttt
     8041 tatggaacgt tattttcaga tagacgatgc gcatttgtcg aaagagtttc aaaaatttcc
     8101 atctttctct attttagatg actgttatcc ttgggatttg agtgaaatat atgatgcgcc
     8161 tgtactttta ttttacaagg gaaatcttga cctcctgaaa ttcccgaagg tagcggtcgt
     8221 gggcagtcgt gcttgtagca aacagggagc taagtcagtt gaaaaagtca ttcaaggctt
     8281 ggaaaatgaa ctggttattg tcagtggtat ggccaagggc attgacacag cagctcatat
     8341 ggcagctctt cagaatggcg gaaaaaccat tgcagtgatt ggaacaggac tggatgtgtt
     8401 ttatcctaaa gccaataaac gcttgcaaga ctacatcggc aatgaccatc tggttctaag
     8461 tgaatatgga cctggcgaac aacctctgaa atttcatttt cctgcccgta atcgcatcat
     8521 tgctggactt tgtcgtggtg tgattgtagc agaggctaag atgcgttcag gtagtctcat
     8581 tacgtgtgag cgagcaatgg aagaaggacg cgatgtcttt gctattcctg gtagcatttt
     8641 agatggacta tcagacggtt gccatcattt gattcaagaa ggagcaaaat tggtcaccag
     8701 tgggcaagat gttcttgcgg aatttgaatt ttaaaaatga cctaagctag aattctaaga
     8761 aaaaatcaat tttaagagaa aatgaaccca acatttccat aataaaacgc atattagcaa
     8821 gtttttaaca cttgataata tgcgtttttt ctaagtggat tagtagagta gaggattttt
     8881 ctcatataat actcttcgaa aatctcttca aactacgtca gcttccatct gcaacctcaa
     8941 aacagtattt tgagctgact tcgtcagtct tatctacaac ctcaaagcag tgctttgagc
     9001 aacctgtggc tagcttccta gtttgcgctt tgattttcat tgagtataag ggaaagtata
     9061 gtgaattgaa ataagatgtg aacaactcta tcaggaaagt caaattaatt tatagaaata
     9121 ttttagcagc caaggtgcac tgttatagat tcaatacaca ataatttagt gtaattgaga
     9181 aaggagaaat gattgtgatt gatgttggct aggttatgtt caatgattcc taccgtctca
     9241 aatcttgtca gtaaggaaaa ataaattctt caaaagtaga gattacaagg cttgtttaag
     9301 aaagaattca aagaccttga caaataaaaa taaaatggtt attataagaa atggtctaaa
     9361 atagatgatg atacttttcg aaaatctttt tacgtcagct cagctttgcc ttgctgtgtt
     9421 ttgagcaagc tacggttagc ttccgagttt gattttcatt tactagaaat gaaactgatg
     9481 agagatatca gtagacattt gagtcaggat attatggaaa atgataaaaa gagctcgtga
     9541 gattggcata tcagactact aaagtattga gtttgttagg attttagcga ctagttagct
     9601 gggaaaggaa gatatttgtg acaaataata aactgtattc gttgatagaa tttagaaata
     9661 aaatatatga agaattagaa ctttccagaa gtgatttagc gattttacta tgtgccatgc
     9721 ttatcgcctc tatcggatta aatatggatt cgactcccgt gattattgga gccatgttaa
     9781 tctctccttt gatgacacct attctgggag tggggctctc tctagctata tttgatttta
     9841 aattgttaag aaaatctttt aaaatattag ctattcaaat tcttgccagt ctaatagctt
     9901 caacacttta tttttgtctt tctcccattt cgtatgctag ttcggagatt gttgctagaa
     9961 cctctccgac tatttgggat gttctcattg cttttgtagg agggatagca ggtattattg
    10021 gtgctaggaa aaaagagacc aataatattg ttcctggtgt tgctattgca accgccttga
    10081 tgcctcctct ttgtacagta ggttatgcta ttgcttctgc taatccaaaa tttatcatag
    10141 gctcctctta cctattcctc atcaattgta gctttattgt cattgcgact tatataggtg
    10201 ttaggttgat gatggttaag aaacattatt ttaaagataa tgaagaagac tctaaaatgc
    10261 gtaggatttt gcttctagtt gctgttttgc tgatgattcc gagttttatt tctgcaacga
    10321 ctttagtgag agaaacgttg aaaaaagagt cccttaagaa atttatatca gagcagtttc
    10381 aggggtataa tattttgaaa aaaacctatt ctaaaaagac tcatacccta aagctaacca
    10441 tttcaggaaa ttatttgaca gaagaagaac tcgatatgat ttcaagtaag agaggtgact
    10501 atggtttaag tgatgtttct gttcaagttt cacaattgtc tgattcagaa caacttagta
    10561 aggaagagct ggtggagtat ttcttccagt atatcaagga taaggaagca aaagaaaagg
    10621 agaaggccaa taaatttgat acagagtctg aggagcaata atttcttgag aatagctggt
    10681 ttctctcgtg agtcttctat gtatatcaaa ggaagactga ggttttaagt ataaaacttt
    10741 tcttctatta tagtagctaa gtcttgacag ggttcaaaaa atggtttaca ctttataaag
    10801 tttattactt tgaaaaggtg tgatactgtg gctacggcaa caaaaaagaa aaaatcaaca
    10861 gttaaaaaaa atctagtcat cgtggagtcg cctgctaagg ccaagacgat tgaaaaatat
    10921 ctaggcagaa actacaaggt tttagccagt gttgggcata tccgtgattt gaagaaatcc
    10981 agtatgtccg tcgatattga aaataattat gaaccgcaat atattaatat ccgaggaaaa
    11041 ggccctctta tcaatgactt gaaaaaagaa gctaaaaaag ctaataaagt ttttctcgcg
    11101 agtgacccgg accgtgaagg agaagcgatt tcttggcatt tggcccatat tctcaacttg
    11161 gatgaaaatg atgccaaccg tgtggtcttc aatgaaatca ccaaggatgc agtcaaaaat
    11221 gcttttaaag aacctcgtaa gatcgatatg gacttggtcg atgcccaaca agctcgtcgg
    11281 atcttggacc gcttggtagg gtattcgatt tcgcctattt tgtggaagaa ggtcaagaag
    11341 ggcttgtcag caggtcgcgt tcagtccatt gcccttaaac tcatcattga ccgtgaaaat
    11401 gaaatcaatg ccttccagcc agaagaatac tggacagttg atgctgtctt taaaaaggga
    11461 accaaacaat ttcatgcttc cttctatgga gtagatggta aaaagatgaa actgaccagc
    11521 aatgacgaag tcaaggaagt cttgtctcgt ctgacgagta aagacttttc agtagatcag
    11581 gtggataaga aagagcgcaa gcgcaatgct cctttaccct ataccacttc atctatgcag
    11641 atggatgctg ccaataaaat caatttccgt actcgaaaaa ccatgatggt tgcccaacag
    11701 ctctatgaag gaattaatat cggttctggt gttcaaggtt tgattaccta tatgcgtacc
    11761 gattcgactc gtatcagtcc tgtagcgcaa aatgaggcgg caagcttcat tacggatcgt
    11821 tttggtagta agtattctaa gcacggtagc aaggtcaaaa acgcatcagg tgctcaggat
    11881 gcccatgagg ctattcgtcc gtcaagtgtc tttaatacac cagaaagcat cgctaagtat
    11941 ctggacaagg atcagctcaa gctatatacc cttatctgga atcgttttgt ggctagccag
    12001 atgacagcgg ccgtttttga taccatggct gttaaattgt ctcaaaaggg ggttcaattt
    12061 gctgccaatg gtagtcaggt taagtttgat ggttatcttg ccatttataa tgattctgac
    12121 aagaataaga tgttaccgga catggttgtt ggaaatgtgg tcaaacaggt caatagcaaa
    12181 ccagagcaac atttcaccca accgcctgcc cgttattctg aagcaacact gattaaaacc
    12241 ttggaggaaa atggggttgg acgtccatca acctacgcgc caaccattga aaccattcag
    12301 aaacgttatt atgttcgcct ggcagccaaa cgttttgaac cgacagagtt gggagaaatt
    12361 gtcaataagc tcatcgttga atatttccca gatatcgtaa acgtgacctt cacagctgaa
    12421 atggaaggta aactggatga tgtcgaagtt ggaaaagagc agtggcgacg ggtcattgat
    12481 gccttttaca aaccattctc taaagaagtt gccaaggctg aagaagaaat ggaaaaaatc
    12541 cagattaagg atgaaccagc tggatttgac tgtgaagtgt gtggcagtcc aatggtcatt
    12601 aaacttggtc gttttggtaa attctacgct tgtagcaatt tcccagattg ccgtcatacc
    12661 caagcaatcg tgaaagagat tggtgttgag tgtccaagct gtcatcaggg acaaattatt
    12721 gagcgaaaaa ccaagcgtaa tcgcctattc tatggttgca atcgctatcc agaatgtgaa
    12781 tttacctctt gggacaagcc tgttggtcgt gactgtccaa aatgtggcaa cttcctcatg
    12841 gagaaaaaag tccgtggtgg tggcaagcag gttgtttgta gcaaaggcga ctacgaggaa
    12901 gaaaagatta aataagagga ggggcccgaa agtaaatttc aggctccttt tggttagaac
    12961 ttgacaaaat acatcatttt atgcgaaact agaagaagat tattttaact aggagaagtt
    13021 atgcgtctta tctatctgat aattggtttt ttatcactgg ccttggctat tgttggggtt
    13081 gttttaccct tgttgccgac aacgcctttc cttttgttgt ctattgcttg tttctccaga
    13141 agttccaagc gtttcgaaga ctggctttat cataccaagc tctatcaaac atatgtagct
    13201 gattttcgcg agactaagtc tattacgcgt gaacgaaaga aaaaaatcat cgtctctatc
    13261 tacgtcttga tgggaatttc tatttatttt gcacctcttt taccagtcaa aatcggtctg
    13321 ggtgctttga ccatctttat cacttattat ctcttcaagg tcattccaga caaagaatag
    13381 ttaaaacagt agttatttgc cttgataaaa ttgaaagcat attcataaca atatgatata
    13441 ataaatttga agtaatattc aaggagaatc aaatgattta cgaattttgt gctgaaaatg
    13501 tgactttact tgaaaaagcg atgcaggctg gagctcgtcg gattgaactc tgtgataatc
    13561 tagcagttgg tgggacaaca cccagctatg gagtgactaa ggcagcggtt gaactggcag
    13621 ctaactacga tacaaccatc atgaccatga ttcggccacg tggtggtgac tttgtctata
    13681 atgacctaga aattgctatc atgctagaag acattcgttt gactgctcag gctggaagtc
    13741 aaggggttgt atttggaact ttaactgctg ataaaaagtt ggataagcct aatctggaaa
    13801 agttaattgc tgcatcaaaa ggaatggaaa ttgtctttca catggccttt gatgaactaa
    13861 gtgatgaaga tcaactggaa gctattgact ggctcagtca agccggtgtc actcgtatcc
    13921 taactcgtgc tggtgtgtct ggcgactcct tagaaaaacg ttttgttcac tatcacagaa
    13981 ttttggagta cgctaaaggt aaaattgaaa ttctaccagg tggggggatt gaccttgaaa
    14041 accgtcaaac ctttattgac caggtggggg taacacaatt gcatggtact aaggttgttt
    14101 tttaaaaaat agaaaggaac tgctagcctt gggtagcagt tttcacttat gtttgaaatt
    14161 tttaaatcct atcaatttaa tcaagaaaag gctcatgatt atggttttat agaaaatagc
    14221 gaagtctgga catatagttg ccagattttg caaggtgact ttgtcatgac tgtgtccatc
    14281 actgctgata atgtgaactt tcaagtcttt gaccaagaga ctggtgacct ctatcctcac
    14341 gttcatatgg aaagcatgag gggaagtttt gtcggaaatg tccgtgaggc ttgtctggag
    14401 attctttacc agattcggaa ggcttgtttt gatgtgcaag attttatctg tcatcagact
    14461 aagcgtatca tgactcaagt tcaggaaaag tatggaaacc agttggagta tctgtgggaa
    14521 aaatcgcctg atacagctgt attgcgccat gaaggcaatc aaaagtggta tgccgtcttg
    14581 atgaaaatct cttggaataa gctggaaaag ggcagagaag gacaagtgga agcagtcaac
    14641 ctcaagcatg accaagtagc taatttgctt tcacaaaagg ggatttatcc agccttccat
    14701 atgagcaagc gctactggat tagtgtgtcc cttgatgata ctttatcaga tgaagaagta
    14761 ctggaattga tagaaaaaag ttggaactta acctctaaaa aatgaaatat tttaataatt
    14821 ttcatgaact ttcaattagc tgaatattct ttactgaaga aattttcaga aaatatagga
    14881 tttaccacac cagaggaatg tggtgccatc ttcaaatacc tgattgagaa tgtcaagacg
    14941 gatcgtcaga tcatctattc gcctcactgt catgatgacc tcggaatggc agtggcaaat
    15001 agccttgctg ctgtcaagaa tggtgcagga cgtgttgaag ggactatcaa tggtattagg
    15061 gagcgagctg aaaatgctgc tttggaagaa attgcagtgg ctctcaatat tcgccaagat
    15121 tactaccaag tagaaaccag tattgtccta aatgagacca tcaatacgtc agaaatggtt
    15181 tctcgcttct ctggtattcc agttcctaaa aacaaagccg tcgttggtgg caataccttc
    15241 tcccacgaat ctggtattca ccaagatgga gtccttaaaa atcctctcac ttatgagatc
    15301 atcacacctg aattggttgg tgttaagatt ccgcttggaa aattatctgg tcgccatgct
    15361 tttgttgaga aactgagaga attggcccta gattttacag aagaggatat caaaccactc
    15421 tttgctaagt tcaaggcact ggccgataag aagtaagaaa tcacagatgc agatactcga
    15481 gctttggtag ctggaaccat ggttgaaaat ccagaaggct tccactttga tgatttacaa
    15541 cttcaaactc atgcagataa tgacattgaa gcgctcgtta gcctagccaa tatggatggt
    15601 gagaaagtcg aatttaatgc gacagggcaa ggttccgttg aagcaatctt taatgctatc
    15661 gataagttct ttaaccaatc tgttcgtttg gtgtcctaca ctatcgatgc ggtaacagat
    15721 ggaatcgata cccaggatcg ggttttggtc actgttgaaa acagagatac agaaaccatc
    15781 tttaatgcag cagggcttga ttttgatgtg ttgaaggctt ctgctattgt ctatataaac
    15841 gctaatacct ttgttcaaaa agagaatgca ggtgagatgg gacgcagtgt ttcttaccac
    15901 gatatgccta gtgtgtaaag gagaaggcta tggcaaagaa aatagtagct ctagcaggag
    15961 acggaattgg cccagaaatc atggaggttg gtttagaagt tctggaggct ctagctgaaa
    16021 aaacaggttt tgactatgag attgacagac gaccgttcgg aggtgcagat attgatgcag
    16081 caggacctcc cttacctgat gaaaccctta aggcaagtag ggaagcagat gctatcctac
    16141 tagcagctat cggtagtcct cagtatgatg gagcagtggt tcgccctgaa cagggcctga
    16201 tggctctccg taaggaactc aatctttacg ctaatattcg tcctgtaaaa atctttgaca
    16261 gtctcaagca tttgtcacca ctcaaactgg aacgaattgc tggtgtagac tttgtcgtgg
    16321 tgcgtgaatt gacaggcggg atttactttg gagatcatat tcttgaagag cgcaatgcgc
    16381 gtgatatcaa cgactatagc tatgaggaag tggagcggat tattcgcaaa gcctttgaaa
    16441 ttgcaagaaa tcgcagaaaa atccttacta gtatcgataa gcaaaatgtt ctagcgacct
    16501 caaaactatg gcggaaagta gctgaggaag tcgcacagga tttcccagat gtaaccttgg
    16561 aacaccagct ggtagactca gctgctatgc ttatgattac caatcctgct aagtttgatg
    16621 ttattgtaac ggagaatctt tttggagata ttttatctga tgaatcaagc gtcttatctg
    16681 gtacacttga ggttatgcca tcagccagtc attctgaaaa tggaccaagt ctctatgaac
    16741 ctattcacgg ttcagcacct gatattgcag gtcaaggaat tgccaatcct acttccatga
    16801 ttttatcagt tgccatgatg ttgagagata gtttcggacg ttatgaggat gcagagcgta
    16861 tcaaacgtgc tgttgagaca agtctggcgg caggaatttt aacgagagat ataggaggtc
    16921 aggcttcaac aaaggaaatg acggaagcta ttattgcaag gttatgaagt tagacgaaaa
    16981 aattactcta gtccttttga tttggaatgt catcattttc ttgatttatg gcattgacaa
    17041 attcaaggca agaagaagag cttggcgcat cccagagaaa atcttactca ttttagccct
    17101 tacttgtggt ggttttgggg cctggttagc tggaattact tttcaccaca agactcgaaa
    17161 atggtacttt aaaacagttt ggtttcttgg gatggtgacc acactagtag ccttatattt
    17221 tatttggagg taatggatgg cagggtcttc gagggaacac gctgcttggg ctctagcgga
    17281 ctatggtttt aaggtcgtga ttgcaggatc tttcggtgac attcattaca ataatgaact
    17341 caataatggc ctgttgccaa tcgttcagcc tagagaggtt agagagaaat tagcccagct
    17401 aaaaccaacc gaccaggtaa ctgtggactt ggaacaacaa aaaatcatct caccagttga
    17461 agaattcacc ttcgagatag atagcgagtg gaaacataaa ctcctaaata gtttggatga
    17521 tatcggtatt accttgcagt atgaagagtt gattgctgct tatgaaaaac aacgaccagc
    17581 ctactggcag gattagaaaa aatagaaaag gaaatatagt aaactgaaat aagatgtaaa
    17641 caaatgaatt agagcttaac atccatttcc agcaattttt tagaaactac agtggactat
    17701 tctggattca acacattata aaattatgac aaaacacatt cacaagaagg ctacgacatt
    17761 ttaaaaggtg agggcggatg tatcgtttgc cctactaaag ttggttacat tatcatgacc
    17821 agcaacaagg caggacttga gcgtaagttc gcagccaaag aacgtaagcg taacaaacca
    17881 ggtgttgttc tctgcggtag catggatgaa ctttgcgctt tagcgcaact caacccagaa
    17941 attgaagcat tctactaaaa acattgggat gaagatattc ttcttggttg tatccttcct
    18001 tggaaaccag aagcctttga aaaactcaaa gcatacgggg atggccgtga agaacttatg
    18061 actgatgtac gtggtactag ctgttttgtt atcaagtttg gaaaagcagg tgaacaattg
    18121 gctgccaagc tttgggaaga aggtaaaatg gtctacgcct catatgcttc aatgacaaaa
    18181 cgattgaaac tcgctatgag agcaaggtgt aatggtgtct atggtcgata aggacggcaa
    18241 actcatccca gaacaaggag gagcacgttc aacctcacca gcaccagttg tgatccgtaa
    18301 agggcttgac attgataaaa tcatgatgca cctgtcagat acttttaact catgggacta
    18361 ccgtcaggtt gagtattatt aggatagaga agaagtctag tgttaaggac attacagctc
    18421 ataatactag gcttttttat agaaattctt ttctttttct ataggatatg gtattctatg
    18481 tagaaaatat atgttaataa gtaatgccaa tatttaaaca tcattagtaa aaggagttag
    18541 attgatgaat aaaagaaaag ttagtttaga agatttttat aaatggtata gtctaaataa
    18601 agaagagtta ttaaataagg caactgttgg tgaaaagttt aatgataaat taaaagaaga
    18661 gtttctccag gaatggcctt tggataggat tttaacaatg tcaatcgatg aatatgtaat
    18721 aggaaaggga cagcaaaata agtctttatg ctacgctctt gagaagggaa aatacaaaaa
    18781 tctatttctt ggaatttctg gtggctcagc ttcaaaattt ggtatttatt ggaataaaaa
    18841 aacaaacaaa tataaagatc aagctaataa tgagatttca gagttggatc agcgattttc
    18901 aaaattaaaa tcagatttgt atgaaattat caaagaaggt attcgtttta actttgaaaa
    18961 tcctattttt gatatgaaaa gatcaacaaa tgaatttatt ggtcgttctg ctatggtgac
    19021 aaaattactt tgtatctatt ctgagggaga tcctttcttt ggtgtaaata ttaatagtca
    19081 gaaagaattt tggaaccact ttgtttctca gacaaatcaa ggtggacctt atctgcaaaa
    19141 tcataaaata attgaactgg tgtccaaaac ttatcctgag ttggagccat cgaaagtagg
    19201 aactatgctt tttgagtatt ctaagctttt tatggaaaat aaggaagaca atagtacaat
    19261 ggattcatca aacaattttc gtcatcaatt aactcaatct ctattaaagt ctccaaacct
    19321 tatccttcgt ggtgctcctg gcacaggaaa gacttatctt gctaaagaaa ttgccaaaga
    19381 attaacggat ggcaacgaag accaaatcgg atttgtacaa tttcacccat catatgatta
    19441 tacggatttt gtagaaggtt taagaccagt atcaaatggg gatggagcta ttgagtttag
    19501 gctacaggac ggtattttta aagatttttg tcagaaagca aaagaaaccc aattgattgg
    19561 aggacaagat aattttgatg aggcttggga ttcttactta gaatatataa atgttgctga
    19621 agaaaaagaa tatataacaa aaacatctta cttatctgtt aatagtagac aaaatttgtc
    19681 agtaaattat gatagtggtg ttccaggatg gtcactacct agcaaatatg tttacgagtt
    19741 gtataaagat aaaaattata ataagcaaga atactacaaa agtggtggaa aaactgtcct
    19801 agaaacattg agaaagagat ttggtttgaa agactatgtt tccccaacag aaattgatac
    19861 tgataagaaa ttcgtcttca tcatcgatga aatcaatcgt ggggagattt ctaagatttt
    19921 tggcgaactc tttttctcta tcgaccctgg ctatcgtggt gaaaaaggaa gtgtttctac
    19981 ccaatatgca aatctacacg aaactgatga aaagttctat atccccgaaa atgtttacat
    20041 catcggaact atgaatgata ttgatcgttc agtggatacc tttgattttg ctatgcgtcg
    20101 tcgttttcgt tttgttgaag ttactgccga gggtcaagtt ggcatgttgg gtaaagagct
    20161 gaatatccat gcagaagaag caaaaattcg tctaagaaac ttgaacgctg ctatcgaaaa
    20221 tgttcaggaa ttaaacagtc attatcatat tggaccaagt tattttctta agttgaagga
    20281 tgtagatttt gactatgaat tactctggtc tgattatatt aagcctctcc tagaagacta
    20341 cttgcgaggt tcttatgatg aggttgaaac tttggaaact ttgaaaaaag catttgaact
    20401 gacaaataat gagcaaaaag atcaggcagt agctgatgac aatgaaggtg atgaaaacga
    20461 tgatgcggat tactgataat caacacaaga ttattaaaga aaaatttgtt gaagaatatc
    20521 ctaaactaag caatcttctt ttagacagaa ccttggaaag tctatcccaa gatgaacgta
    20581 ttttcatttt tccaaatgat ttgactcata ctcctgattt ggataaggac caaaagattt
    20641 ttgaaacagt caatcagaaa atcaagacag ggaacgtgat tggttttctt ggatatggtc
    20701 aggaaagatt aacgatttcc tcacgatttt ctgatgagag taatgaccat tttttgcatt
    20761 atctcttaaa caaggttctt catatcaatc tcactagttt agatgttgct ttgtctcgtg
    20821 aagagaggct ttatcaactt ttggtgtatc tctttcccaa gtatctacaa gctgctattc
    20881 gaaaaggtct ttataaggaa tatcatcgat tttctcataa cgacagtcat gttaagggag
    20941 tgattgatgt aagaagccat ctcaagaaaa atcttccttt cacgggaaat attgcctacg
    21001 caacgagaga gttcacctat gataatcccc tcatgcagtt ggtccgtcac actattgaat
    21061 acattaagaa tcagaaaagc attggtcaag gggtactaga taatctctca actagtcgtg
    21121 aaaacgtatc tgaaatcgtg cgtgtaacgc cctcttataa actagctgat cgtgctaaga
    21181 ttattcgggg aaatcaatct aaacctatac gtcatgcata ctttcacgag tacagaaact
    21241 tacaagaact ttgtctgatg atcctaaacc aagaaaagca cggtttaggg tatcaagatc
    21301 aaaaaatcta tggtattctc tttgatgttg cctggctttg ggaagagtat gtttacacct
    21361 tgttgccaaa aggttttgta catcccagaa ataaggataa gacggatgga atttcagtat
    21421 tttctgttgg gaaacgaaaa gtatatccag atttttatga cagagaacga aagattgttc
    21481 tagatgcaaa atataaaaaa ctggaattga ctgaaaaagg aatcaaccgt gaggacttat
    21541 tccagctgat ttcctattct tatattttaa aagctgagaa ggctggactg atttttccta
    21601 gtatggagca gtcagtaaat agtgaaatag gaaaagtagc tggctatgga gctcaattga
    21661 agaagtggtc tattcgaatc cctcagaatg cctcattcta tagtacattt tgtaaaatga
    21721 tggaaaattc agaagaaaat tttaaagcga ttattgatga agaagtgggg agaaaataat
    21781 ttcccctctt tcttttattt ttaacacaag taaaacccga acgatatatt ttaattcata
    21841 aaataatttg acaaaaactg tactttggtt tataataaat taaggaaacg tcggaaaagg
    21901 cgtagtgatg caagagcata ggtaggtcat tacaaaagaa acgagacatc gatatgttaa
    21961 atgaatttcc aatttttgat tacgaagata ttcaattgat tccaaataaa tgtgtcatta
    22021 aaagccgtgc agaagcggat acaagtgtca ctttaggaaa tcacaccttt aaactacctg
    22081 ttgtgccagc gaatatgcag acgattttgg atgaaaatgt agcagagcaa ctggctaaag
    22141 gtggttactt ctacattatg caccgttttg atgaggcagg acgcattcct tttattaaac
    22201 gaatgcacga tcaagggctc attgcttcta tctctgtcgg tgttaaggat tatgagtatg
    22261 attttgttag ccagctcaag gctgatgctc ctgagtatat cactattgat attgctcatg
    22321 gtcatgcgga tagcgtgatt tctatgattc aacacatcaa gaaagaattg ccagatacct
    22381 ttgtcattgc tggaaatgtg ggaacaccag aagctgtgcg tgaattggaa aatgctggtg
    22441 cggatgctac taaggtcgga atcggtcctg gtaaggtttg tatcaccaag gttaagactg
    22501 gttttggtac aggtggttgg cagttggctg ctctacgctg gtgtgccaag gctgcgcgta
    22561 aaccgattat cgctgatgga ggaattcgta ctcacggtga tattgctaag tctatccgct
    22621 tcggtgctag catgatcatg attggttccc tctttgcagg acacattgaa agtccaggga
    22681 aaacgattga agtcgatggt gaacagttca aagaatatta tggttcagcc tcacaatatc
    22741 aaaaaggtgc ttacaaaaat gtggaaggca aacgtatctt gcttcctgct aaaggtcatc
    22801 tgcaagacac tttaactgag atggaacaag accttcaaag tgctatttct tatgcaggtg
    22861 gacgtcaggt tgctgacctt aaacacgttg attatgtgat cgtgaaaaac tccatctgga
    22921 atggggatgc ttcccactaa gacggggtct ttgaccaaaa aacttgttat tagagcaaat
    22981 ttctgttata ataaaacaag tttccaccct tagtgtaatg gatatcacgt aagattccgg
    23041 ttcttgagat gggggttcga ttccctcagg gtggatgtaa acatcctaaa aagcctttaa
    23101 tagggctttt ttctttatcc tgacccaaat ttgccgctaa aactgagaat ctctgtctaa
    23161 agaattccca aatgctttcc agtcccgttt tagagtgact cagggggctt tttttgatat
    23221 aataaaaagg actattatca gttagaaaga ggttggtatg aaagaattac aaactgtact
    23281 aaagaaccat tttgcaatcg aatttacaga caaaaagtta ctggaaactg cctttactca
    23341 tacgagttat gccaatgagc accgcctctt aaaaatttca cacaatgaac gcttggaatt
    23401 tttaggagac gctgttctac agttattgat ttcagaatat ctatataaaa aatatcctaa
    23461 aaagcctgaa ggtgacctat caaaactccg tgctatgatt gtccgtgagg agagtttagc
    23521 tggttttgcg cgtgattgcc agtttgacca gtttatcaag ttgggtaaag gggaagaaaa
    23581 atctggtggt cgcaatcgtg acaccattct tggtgatgcc tttgaagcct ttcttggtgc
    23641 ccttcttttg gataaggatg tggccaaggt caaggaattt atctatcaag tcatgattcc
    23701 taaggttgaa gcaggcgagt ttgagatgat tacagactat aaaacccatc tccaagagtt
    23761 gcttcaggtc aatggtgatg tggctattcg ttatcaggtg atttctgaaa cagggcctgc
    23821 tcacgataag gtctttgatg tagaagttct tgttgaaggt aagagcatcg gtcaaggcca
    23881 aggtcgttct aagaaattag cagagcagga agctgccaaa aatgccgttg agaaggggct
    23941 ggattcatgt atttaaagga aatcgaaatt caggggttca agtcttttgc tgataagacc
    24001 aaggtcgttt ttgaccaagg tgtgacggca gttgttggac ccaatggatc tggaaagtcc
    24061 aatattacag aaagtctgcg ttgggctttg ggggagtcta gtgtcaagag tctccgtggg
    24121 ggcaagatgc cggatgtcat ctttgctgga accgaaagtc gcaaaccgct caattatgct
    24181 tctgtagttg tgactctgga taatcatgac ggatttatca aggatgcagg tcaagaaatc
    24241 agggtggaac gccatatcta tcgtagtgga gatagcgaat acaagattga cggcaagaaa
    24301 gtccgtctgc gtgatattca tgacctcttc ttggatactg gattgggacg agattccttc
    24361 tctattattt cccaagggaa ggttgaggag atttttaatt ccaagcctga ggaacgacga
    24421 tctatttttg aagaagctgc tggagtttta aaatacaaga ctcgcagaaa agaaaccgag
    24481 agtaaactgc agcaaactca ggataatctg gaccgcttag aggacattat ctacgagttg
    24541 gataatcaaa tcaagcctct tgagaagcaa gctgagaatg cccgtaagtt tttagacttg
    24601 gaaggacaac gtaaggctat ttatttagac gttctggttg ctcaaatcaa ggaaaataag
    24661 gctgaactag agtcgacaga agaagagttg gctcaggttc aagaactctt gatgagttat
    24721 taccaaaagc gtgaaaaatt agaagaagaa aatcaaactc ttaaaaagca acgccaagat
    24781 ttacaggctg aaatggccaa agaccaaggc agtttgatgg acttgactag tctgattagt
    24841 gatttagaaa gaaaattagc cctatcgaaa ctggagtccg agcaagtggc cttgaatcaa
    24901 caggaggtac aagctcgttt ggctgctttg gaggataaga gaaattcact cagcaaagaa
    24961 aagtctgata aagaaagctc tttagctctg ttagagggaa atctagtcca aaataatcaa
    25021 aaactcaatc gtttagaagc tgaattgctg gctttctcag acgatcctga tcagatgatt
    25081 gagctcttac gtgaacgctt tgtagctctt ttacaagaag aagcggatgt ctcaaaccag
    25141 ttgacccgta ttgagaatga gttggaaaat agtcgtcagc tttctcaaaa acaagcagat
    25201 caactagaaa agctgaaaga gcaattggct atagctaaag agaaggctag tcagcaaaag
    25261 gaagagcttg aaactgccaa ggagcaggtt cagaaattat tggctgacta ccaagctatt
    25321 gccaaggagc aagaggagca gaaaacttcc tatcaagctc aacaaagcca actctttgac
    25381 cgtctggata atctcaaaaa caagcaggcc agagctcaaa gtttggaaaa tatcctgaga
    25441 aatcatagta acttttatgc aggtgttaag agtgttctcc aagaaaaaga tcgcctaggt
    25501 gggattattg gtgcagtcag tgagcatctg acctttgata tgcattatca aactgcccta
    25561 gaaattgcac ttggagcgag tagtcagcac attattgtag aagatgagaa tgcggcaacc
    25621 aaagccattg atttcctcaa acgaaacaga gccggtcgtg caacctttct tcctttgacc
    25681 actattaagg cgcgtacgat ttctagtcag aaccaagatg ctatcgctgt aagcccaggt
    25741 ttccttggga tggcagatga gttagttact ttcgatacta gactggaagc cattttcaag
    25801 aacttgctag ctacgacggc tatctttgat accgtagaac atgcgcgtga agctgctcga
    25861 caagttcgtt atcaggttcg catggtgaca ttggatggga cagagcttcg tacaggtggt
    25921 tcctatgcag gtggagccaa tcgtcagaac aacagcatct tcatcaagcc agaactggag
    25981 caattacaaa aagaaattgc tgaagaagaa gcaagcttgg attcagaaga agtggctttg
    26041 aagaccttgc aagatgagat ggccagattg atcgagtcat tagaagctat taaatctcaa
    26101 ggagagcagg cacgtattca ggagcaaggc ttgttcctcg cttatcagca aactagtcag
    26161 caagttgaag agctagaaac tctttggaaa ctccaagaaa aggaattaaa tcgtctttct
    26221 gatggagatt ggcaagcaga caaggaaaaa tgccaagaac gccttgctac tatcgccagt
    26281 gacaagcaaa atctggaagc tgagattgaa gagattaagt ctaacaaaaa tgccatccaa
    26341 gaacgctatc aaaacttgca ggaagagcta gcgcaagctc gtttgcttaa gacagaactg
    26401 caagggcaaa aacgttatga agttgctgat attgaacgct taggcaagga attggacaat
    26461 cttaatatcg aacaagaaga aatccagcgc atgctccaag aaaaagttga caatcttgag
    26521 aaggttgata cagaattgct cagtcaacag gcggaagaat ccaaaactca gaaaacaaat
    26581 ctccaacaag gtttgattcg caagcagttt gagttggatg atatagaagg tcaactggat
    26641 gatattgcca gtcacttgga tcaagctcgc cagcagaatg aggagtggat tcgcaagcaa
    26701 acacgtgctg aagccaagaa agaaaaggtc agcgagcgct tgcgccatct acaaagtcaa
    26761 ttaacagacc agtaccagat tagctatact gaagctctag aaaaagcgca tgaattggaa
    26821 aacctcaatc tggcagagca agaagttaag gatttagaga aggctattcg ctcactgggt
    26881 cctgtcaata tagaagctat tgaccagtac gaagaagttc acaaccgtct ggactttcta
    26941 aatagtcagc gagatgatat tttgtcagcg aaaaatctgc tccttgaaac cattacagag
    27001 atgaatgatg aggtcaagga acgctttaaa tcaacctttg aagctattcg tgagtccttt
    27061 aaagtgacct tcaagcagat gtttggcgga ggtcaggcag acttgatatt gactgagggc
    27121 gaccttttaa cagctggtgt ggagatttct gttcaacctc caggtaagaa aatccagtcg
    27181 cttaacctca tgagtggtgg tgaaaaagct ctatcggctc ttgccttgct tttctccatt
    27241 attcgtgtca agaccattcc ttttgtcatc ttggatgagg tagaggctgc gctagacgaa
    27301 gccaatgtta aacgtttcgg ggattatctc aaccgctttg ataaggacag tcaatttatt
    27361 gtcgtaaccc accgtaaggg gaccatggca gcggccgatt ctatctatgg agtgaccatg
    27421 caagaatcgg gtgtttcaaa gattgtttca gttaagttaa aagatttaga aagtattgaa
    27481 ggatgacaat taaactagta gcaacggata tggacggaac cttcctagat gggaatggac
    27541 gctttgatat ggatcgtctc aagtctctct tggcttccta caaggaaaaa gggatttact
    27601 ttgcggtggc ttcgggtcgg ggatttctgt ctctggaaaa attatttgct ggtgttcgtg
    27661 atgacattat tttcatcgcg gaaaatggca gtttggtaga gtatcaaggt caggacttgt
    27721 atgaagcgac tatgtctcgt gacttttatc tggcaacttt tgaaaagctg aaaacgtcac
    27781 cttatgtaga tatcaataaa ctgctcttga cgggtaagaa gggttcatat gttctagata
    27841 cggttgatga gacctatttg aaagtgagtc agcattataa tgaaaatatc caaaaagtag
    27901 cgagtttgga agatatcaca gatgacattt tcaaatttac aaccaacttc acagaagaaa
    27961 cgctggaagc tggtgaagct tgggtcaatg ataatgtccc tggtgtcaag gctatgacaa
    28021 ctggctttga atctattgat attgttctgg actatgtcga taagggtgta gctattgttg
    28081 aattagctaa aaaacttggt atcacaatgg atcaggtcat ggcttttgga gacaatctta
    28141 atgacttaca tatgatgcag gttgtgggac atcctgtagc tcctgaaaat gcacgacctg
    28201 aaattttaga attagcaaag actgtgattg gtcaccataa ggaacggtcg gttatagctt
    28261 atatggaggg cttataatgg cagatataaa attgattgca ttggacttgg acgggacctt
    28321 gctgactact gataaaaggc tgacggatcg taccaaggaa accttgaaag ctgcgcgtga
    28381 tcgtggtatc aaggtcgtat tgacaactgg tcgtccctta aaagccatgg atttctttct
    28441 ccatgagtta gggactgacg gtcaggaaga tgagtatacc attactttta atggtggatt
    28501 agttcagaaa aatacaggag aaatccttga taaaacagtc ttttcatatg atgatgtggc
    28561 acgtttgtat gaagaaacag agaaattatc actgcctctt gatgccatct cagaaggaac
    28621 agtttatcaa atccaatcgg accaagaaag tctttatgcc aaattcaatc cagctttgac
    28681 ctttgttcca gtggactttg aagacttatc tagtcaaatg acctacaaca aatgcgtgac
    28741 tgcctttgct caagaaccct tggatgcagc cattcagaag atttctccag aattgtttga
    28801 ccaatatgaa atctttaaat cacgtgaaat gttgctagaa tggtcaccaa agaatgttca
    28861 taaagcaaca ggtttggcaa aactaatcag ccatcttgga atcgaccaaa gtcaagtgat
    28921 ggcttgtggt gacgaggcca atgacctctc tatgattgaa tgggcaggtc ttggtgttgc
    28981 tatgcaaaac gctgttcctg aagtaaaggc agccgcaaat gtagtgacgc cgatgaccaa
    29041 cgatgaggaa gctgtcgcct gggctatcga agaatatgtg ctaaaggaga actaagatat
    29101 gggattgttt gaccgtctat tcggaaaaaa agaagaacct aaaatcgaag aagttgtaaa
    29161 agaagctctg gaaaatcttg atttgtctga agatgttaat cctaccttca cagaagttga
    29221 ggaagtttct caggaagaag cagaggttga aattgttgaa caagctgtgt tccaagaaga
    29281 ggaaatccaa gacacagttg aagaaagtct ggatttagag ccagttatag aagtttctca
    29341 aaaagaagtc aaagaatttc cacactcaga agaagggaat actgagtttc tagagactgt
    29401 agaagaaaat aattctgaaa ttcttgaagc agaaaggcct caaacagaag aaactgttca
    29461 ggaaaaatat gaccgcagtc ttaagaaaac tcgcacaggt ttcggtgccc gcttgaatgc
    29521 cttctttgct aacttccgct ctgttgacga agaatttttc gaggaactgg aagaactgtt
    29581 gattatgagt gatgttggtg tccaagtcgc ttctaactta acggaggaac tacgttacga
    29641 agccaagctt gaaaatgcca agaaacctga tgcacttcgt cgtgtcatca ttgagaaatt
    29701 ggttgagctt tatgaaaagg atggtagcta cgatgaaagc atccacttcc aagataactt
    29761 gacagttatg ctctttgttg gtgtgaatgg tgttgggaaa acaacttcta tcggaaaact
    29821 agctcaccgc tacaaacgag ctggtaagaa ggtcatgctg gttgcagcag ataccttccg
    29881 tgcgggtgca gtagctcagc tagctgaatg gggccgacga gtagatgttc cagtagtaac
    29941 tggacctgaa aaagctgatc cagccagcgt ggtctttgat ggtatggaac gtgccgtggc
    30001 tgaaggtatc gatattctca tgattgatac tgctggtcgt ctgcaaaata aggataacct
    30061 tatggctgag ttggaaaaga ttggtcgtat tatcaaacgt gttgtgccag aagcaccaca
    30121 tgaaaccttc ttggcgcttg atgcatcaac aggtcaaaat gccctagtac aggccaaaga
    30181 attttcgaaa atcacacctt taacgggaat tgttttgact aagattgatg gaactgctcg
    30241 aggaggtgtg gttctagcca ttcgtgaaga actcaatatt cctgtaaaat tgattggttt
    30301 tggtgaaaaa atcgatgata ttggagagtt taactcagaa aactttatga aaggtctctt
    30361 ggaaggctta atctaatcag aagcaaaaat cctgcaaggt acaaacttgc aggatttttt
    30421 tattctaagc gaccatcttg acgataggcg atatctggtt gccaagtcca tttggcaccg
    30481 aatttttcaa gtaggtcaaa gctggcttga ggtcccatgc ttccagcttt atagtcatga
    30541 agtgggacac cattttcagc ccagagcttt tcaatacgat caatcaactt ccatgacgca
    30601 ccaacttcat cccagtggct aaagttagtt gagttgttat ttaggacatc ataaatcaat
    30661 ttttcgtatg gttctggaga agcaccagtt gcagtcgcgt ctgtacgata atcaagtgag
    30721 ttaggagcca agttaaattc ttctcctact tgcttcccat ttaggctaag agagaagcct
    30781 tctgttggtt gaatatagat ggtcaaaata tttggagcaa gtggttctcc aaagatagaa
    30841 tccatttgtt taaagacgat gttgacatga gttccttttt cagtcagtcg tttacctgta
    30901 cggaaaaaga aaggaacact acggaatcga tcgctgtcta caaagaaggc accagatgta
    30961 aaggtttcag ttgttgattc tggattcaca tttggctcgc tacgataaga gatgtatttc
    31021 atgccatcaa tcttaccaga gcggtattgc ccacggataa agtgttcttt gagttcttca
    31081 tcagttggat gatagaggtt tttaaagacc ttaatctttt cagcacgaat ctcgtctttt
    31141 gtgaagcttg ctggtttgtc catggcgaga agcgaaagaa gttgtagagt gtggttttgg
    31201 accatgtcac ggagggcacc ggattggtca tagtagccac cacgttcttc tacacccaag
    31261 cgctccgcaa aggtaatttg aacattgtcg ataaaatcct tgttccaaac gttttcaaaa
    31321 atcaagtttg caaagcgaac tgcaaagatg ctttggatca tttccttacc aagataatgg
    31381 tcgatacgga aaatttgttc ttcgtcaaat gttgctagga gttcgtcatt caacttgctt
    31441 gcagttgcgt aatctgtacc aaatggtttt tcaacgatca agcgctcaaa acctttgtca
    31501 tcgacaatgt tttcagattt gaggtgtttg gcaatggttc caaagaactg aggtgccata
    31561 gacaagaaga agagcttatt gtgttcagct tggtattttt cattaagctc agcttgtaat
    31621 tgacgcaaag caatataatg ttccgaatca ttgacatcat ggctttgata gtagaagtgg
    31681 ctagcaaatt cttgggcttg ctcggtacta tctgccaaat caaggatgga ctcgacaact
    31741 acagattcaa aatattcctt actccaaggt ctacgggcag ttccaataac ggcaaagtgc
    31801 ttggaaagat tgccggattg atatagtcta aaaagggaag ggtagagctt gcgtttagcc
    31861 aggtctccac tcgcaccgaa aattgtaaca ataaccttag atgacatcta gctacctaat
    31921 ttctattttt attcctagtc ttgctaggta tgaggaaacc tcatttcata aacttaattc
    31981 taacataatt ttccgaaaaa tcaaaaattc caatacgagg tagaaaaact gcaaggaaat
    32041 ccttacagtt tgagtttaga cgtttaagac cttatctaag aactctttca gacgagggtg
    32101 ttgtgggtta tcaaagattt ggtcaggtgt tccgtcttca aggaactcgc catctgcagt
    32161 aaagataacg cggttggcaa cctgacgagc aaatcccatc tcatgggtta cgataatcat
    32221 ggtcatgcct tgctcagcca attccttcat aacgttaagt acgtctccaa ccatctcagg
    32281 gtcaagggca gaagttggtt catcgaagag catgatgtct ggattcattg ctaggccacg
    32341 agcgatggcc acacgttgtt tttgaccacc tgataggcta tctggattgg cattagcttt
    32401 atctgctagt ccaacctttt caagcaactc cattcccaat ttctcagctt cttccttagt
    32461 catcaacttg tgctcaatag gagcaaaggt gatgttgtcc aatacagaca tatgagggaa
    32521 gaggttgaag tgttggaata ccatgccgat attttcacgg acgtggtcaa cattggttgt
    32581 tttttcagtt aaatcatagc cgttcacagt gatgtgaccg ctagtgactt cttctaaaag
    32641 attgaggcta cggaggaaag ttgacttacc agaacctgaa ggaccgatga tacaaacaac
    32701 atctccttca tagaacttag tcgtaattcc ttttaggact tcattttttc catagtgctt
    32761 gtgtaaatca tttacatcaa tttttaattt tgccattaac gaatcctctt ttctaagcgt
    32821 ttcgctagtc tagtcaaaag tgtgataatt acaagataga agatagcaag gattgcatac
    32881 atcttgaaac tttggtagtt acgagcaatg ataatcttac cagtttggaa gagttcaacc
    32941 aaaccgatag cagatacgat agttgtatct ttaagagcga taacgaattg gttgacaaag
    33001 tttggcaaca tcaatttagt tgcttgtggc aagataatct tacgcatggt ttttccataa
    33061 gagataccca agcttcggct ggcttccatt tggccaactg gaacggcctg aataccacca
    33121 cgaacgattt cagcgatata agcagccgca ttgagtgaga gggcaattgt tccagctaca
    33181 aagtcgttaa ttgggctttg ttggcctgtg atagactcga tgaagtttgg aattccccag
    33241 aagatgaagg ctgcaagaat catcaatgga ataccacgaa taacgtcaac gaaaatctca
    33301 gagatgacgc gaagagattt gtatgggcta acgctaaaca taccgaagat aattccgatg
    33361 acaatggcaa tagcaaatga gataagagct agagcaagag tgataccaag accgctaagg
    33421 agttgtttgt agttgttttg aagcaagccc cagagcgttg tttcgtcaac agtacttgtt
    33481 gaagcagttg aagattcgct agctaggtat ttgtcaagaa tcttttggaa ttcaccgttt
    33541 gctttaaggt ttgcaagtcc gttgttgaac atttcaatca gttctggatt tgctcctttt
    33601 ttaacggcaa aggctgtttc accgattgga gttccagaga ttggagtttt caatttttga
    33661 ccttggctga tagaatattt gagaacaggt tcatcatcca taacggcatc aatggcacca
    33721 gtgtttaaac tgtcatacat tgaagaacca tcagcaaagg ttttgatttt gtagccgtat
    33781 ttgctttgat tttctgttag gaaggtttga gaagcagttc cgtttttaac accgactgtc
    33841 tttcctttta gatcttcata agaagcaata ttgcttgatt ctttgacacc aagaatggta
    33901 ttagcagtgt agtatgattc tgagaagtca aaagttgcct tacgagcatc tgtgacagac
    33961 ataccagcga tgataccatc ggcttgacca gcttggacag cactgatagc agcatcaaaa
    34021 ccagggttgg tgatttcaat ttcaaaacct tggtctttag cgattgcctt aatcaattcc
    34081 atatcaatac cagtgtattg gttgcttgaa ttttggaaaa caaaaggtgc aaaagaagaa
    34141 tcgctggcaa tgatatattt agccttaaca ggaatagctt ttaatcctgc gagagtagtt
    34201 gtagttggca ctgctgaaga tgatgaagca gtccatttct tgataatttt atcaagacta
    34261 ccatcttttt tcatttcaga caaggcttgg ttaaattcag taaccaggtg ctcgtattta
    34321 cttccttttt tcacaccgaa agcaaaactt cctacagctt caccatccat ttcaatatgg
    34381 aggtcttgac cttggttaat ggcatattcg ataacaggtt tgtcatccat catggcatcg
    34441 atggcaccag cactcaagct gttgttcatt aaatcaccag tgtcaaatgt tttaatagta
    34501 aagccgtatt tatctttgat tgtttcaagg aaacgttgag cggcagttcc gtttttaaca
    34561 ccaacggttt tgccagttaa ttggtcgtac ttgctaattt tgtgtgactt tgtagtagca
    34621 atgacaactt ttgtatcata gtaagtatca gacatggtga agactttttc acgttcttta
    34681 gtctttgtca tccctgccat gatagcgtcg gcttgcccag cttgaaccgc attgaccgct
    34741 gcgtcaaatc caggatagga catctgaatg ttccagcctt taatctcagc gactttgtta
    34801 ataatgtcaa catcaattcc tttataagtt tgatctgaat ctttaaactc aaaaggtgca
    34861 taggcggtat cagaaacaat cttaatcgtt tctgctttgg caatacctaa tgagaaaatt
    34921 gggaataaaa ttagcaaaaa tgctagaaat tttttcttca tttttagtct ccttttccga
    34981 atattctctc attatatcag aaaaagtaaa aaaaggcaaa tttttatatt ttcgtgtcag
    35041 aaaatataac attgattttt ccttttcttt cttgaattgc tattaaaaag tgctataata
    35101 atagtatata tagaagaaaa gaggacgggg atatgaagaa caaaagaata tttaaagact
    35161 tccaagcttc aaaaatgaat ttaaacattt acacaagccc cttgttagcc tttgtttttg
    35221 tcttcatagg agagtttgtg gcttatactt tatatggtat tagtttgtta gctctcatcg
    35281 ggcttgctag aaattttgga gaggctggtc aaaatcttgc aagctacttg cagaccttgc
    35341 atcagagctt gatggataaa acaagtgact ttcgtttaat tttaggatta ctggcctttg
    35401 gttttattct taacactgtg ttcagatgga caagaaaagt tgagaaaaga cctattcgaa
    35461 ccttgggatt ttatagagag aatttcctca gcaatcttct gaaaggattt agtctaggcc
    35521 tggcactttt tcttctgacc ttgttaggtt tagtggtctt agatcaatat cgtttggaat
    35581 ccattcactt gaatccttat tctcttgcct ttgtcgtctt tactatccca ttttggattt
    35641 tacaggggac agcagaagaa gtggtggccc gtgcttggct acttcctcaa ttggcctcaa
    35701 gaaccaatct aaaactagct attcttatat ctagcctgtt ctttaccctg cttcatatgg
    35761 gcaattctgg cctcacccct ctatctctag taaatctctt tttattcgga gttaccatgg
    35821 ctctttacct tctcaaaact gatacagttt ggggtgttgc aggtattcat ggtgcttgga
    35881 attttgctca gggtaatctc tttgggattt tagttagtgg tcaaccgtca ggaacgtctc
    35941 tgatgacctt tttaccacaa ggcaatcaag attggctatc aggtggttct tttggcatag
    36001 aaggttccat tatgacaagt ctggtattac tactgctgat tgtctatctt gctaataaat
    36061 taaagaaaga aaatgaaagg atgtgacttc ggtccgtcct tttcttcgtg aaaatactat
    36121 aagtatgcta aaataggaat agcacatgga gagaggattc ttatgatcaa tcacattaca
    36181 gataatcaat ttaaactagt atcaaaatat caaccatcag gagatcaacc ccaagctatc
    36241 gagcagttgg tggataacat tgagggggga gaaaaagctc agattctgat gggggcgact
    36301 ggaacaggga agacctatac tatgagtcag gtcatttcta aagtcaataa accaactctg
    36361 gttattgccc acaataaaac tctggctggt cagctctatg gggagtttaa ggaatttttc
    36421 cctgaaaatg cagttgagta tttcgtatcc tactatgatt attaccagcc agaggcctat
    36481 gtcccttcta gcgataccta tattgagaag gatagttctg tcaatgacga gattgacaag
    36541 cttcgccact cagctacctc agcccttttg gagcgtaatg atgttattgt cgtggcctca
    36601 gtctcttgta tctatggttt gggttcgccc aaggaatacg ctgatagtgt cgttagtctc
    36661 cgtcctggtc tagagatttc tcgtgataaa ctcttgaatg acttggtcga tattcagttt
    36721 gaacgtaatg atattgattt ccaacgcgga agatttcgcg ttcgtgggga tgtggtagag
    36781 attttcccag cttcccgaga tgaacatgcc tttcgagtag aattttttgg agacgaaatt
    36841 gaccgtattc gtgaagttga ggctctgaca ggtcaggtgc tgggagaagt ggatcattta
    36901 gcgattttcc cagcgacaca ctttgtgacc aatgacgacc atatggaagt tgccgttgcc
    36961 aagattcaag cagaattaga agagcagtta gctgtctttg agaaggaagg taaattgctt
    37021 gaagcccagc gcttgaaaca acggacagag tacgatatcg aaatgctgcg cgagatgggc
    37081 tatacaaatg gggttgaaaa ttattctcgc cacatggatg gacgtagtga aggtgagcct
    37141 ccttatacgc ttctcgactt cttcccagat gattttttga ttatgattga cgagagtcat
    37201 atgactatgg gacaaataaa aggcatgtac aatggagacc gttcgcgtaa ggaaatgcta
    37261 gtaaattatg gtttccgttt accgtctgcc ttggacaatc gtcctctccg tcgtgaggag
    37321 tttgaaagcc atgtgcatca gattgtttac gtatcagcga cacctggtga ctatgaaaat
    37381 gaacagactg agacggtgat tgagcaaatc attcgaccga cagggctttt ggatcctgag
    37441 gtggaagtcc gtccgactat gggacagatt gatgatctct taggtgaaat caatgcccgt
    37501 gttgaaaaga atgaacgaac ctttatcacc accttgacca agaaaatggc agaggacttg
    37561 accgactatt tcaaggaaat gggcatcaag gtcaagtaca tgcactcgga tatcaagacc
    37621 ttggaacgga cggagattat ccgtgatctc cgcttgggtg tctttgatgt cttggttgga
    37681 atcaatctcc ttcgtgaagg gattgacgtt cctgaggtta gcttggttgc cattctcgat
    37741 gctgacaagg aaggtttcct tcgtaacgag cgtggactca tccagactat tgggcgtgcc
    37801 gcccgtaaca gtgaaggtca tgtcatcatg tatgcagata cggttaccca gtctatgcaa
    37861 cgtgctatcg atgaaactgc ccgccgtcgg aaaattcaga tggcctataa tgaagagcat
    37921 ggtatcgtac cacagacaat caagaaagaa atccgtgacc tgattgccgt gaccaaggca
    37981 gttgctaagg aagaggacaa ggaagtcgac atcaatagcc tcaacaaaca agagcgcaaa
    38041 gaactcgtca agaaactaga aaaacaaatg caagaagccg tcgaagtgct tgactttgaa
    38101 ctggcggctc agatccgtga tatgatgttg gaagtcaagg ccttggatta ggggaatagt
    38161 atgatttatt taagaaagtt aaagagagaa gatttgatgt ctttatggga aatggcttat
    38221 tcacaactta atccagtttg gaaacagtat gatgctccct attatgatga ttatcagtat
    38281 ttttcaaatt ttaaagaatt cgaactacaa aaatcagaat ccattttaag caactcaaat
    38341 cgccttggta tttttgttga tgataaacta gttgggactg tttcgcgtta ttgggtatgt
    38401 aaacaaacaa gatggatgga attgggaatt ggtatttatg ataaaaaatt ctggaacact
    38461 ggtattggga aagttgctat gttgcagtgg atagatagga cgtttcagga ttacttggag
    38521 ttggagcatc tgggtttgac aacttggtca gggaatcttg gtatgatgaa acttgctgaa
    38581 aaattaagaa tgaaaaaaga agctcatatt ccaaaagttc gttattatca aggtaaatat
    38641 tttgatagta ttaaatatgg tattttgaga gaagactggg agaaaataaa tgacggttat
    38701 tataaaatca atggaaactc ctgaagagat agaaggtaaa tccctcgttc actggcaaac
    38761 gtggagagag gcttatgatg accttttgcc tgcagaattt caggagacaa tgacattaga
    38821 aagatgtcga ttctttagtc aaaagtatcc agaaaataca ttgattgcga tagatgacgt
    38881 gaaggtagtt ggttttatca gttatggaaa ctttcgtgat gagactattc aagctggtga
    38941 aattattgct ttatatgttt taaaagacta ttacggaaaa ggcatagcac aaaagttaat
    39001 gaaagcagct ttgactgctc tgaatcattt ttctgaaatt ttcttatggg tattgaaaga
    39061 taacaagcga gccattgctt tctatcaaaa aatgggtttt acttttgatg gacaagaaaa
    39121 gatacttgaa cttggaaagc ctataaagga aaaacgaatg gtattctatt ctaaaataat
    39181 tttaaaaagt agaagctaat ggcactggta ccaagtctga aaatttaata aattagaaag
    39241 cgagtaaatt tatgtcccgt tcccaattaa cgattttaac aaccatttgt ctgattgaag
    39301 acctcgaaac gcagcgcgtg gtgatgcagt atcgctctcc tgcaaccaat cgctagtctg
    39361 gttatgcctt tcctggaggt catgtagaaa atggcgagtc tttcgcagag tctgtcattc
    39421 gtgaaatcta tgaagaaaca gggttgacta tccaaaatcc tcaacttgtc ggcattaaaa
    39481 attggccact agatacaggt gggcgctata ttgtcatttg ttataaggcg actgagttct
    39541 ctggtaccct tcaatcttca gaagagggag aagtttcttg ggtgcaaaaa gaccagattc
    39601 caaacttgaa tctggcctat gatatgctac cattgatgga aatgatggaa gctcccgaca
    39661 agtcagagtt tttctaccct cgccgtacag atctaacttt cccatctttg agatagccct
    39721 tcacaagata gacatgagta cgcctttctt tgttgtttta ataaacgctc tactccatta
    39781 ctccatatat aaccaatata caacaaatag ttgggaacaa actgtggtag atgtcgaacg
    39841 tcttcgtgat gaggctatag ctctaggagt agcttaatga caaagagaca gtaggagagg
    39901 tacgattatg ttactcttta tgttttcgtt caataatata ataataaatc ctagtatgtt
    39961 cctattgttc gatagtacag gagcttacta tcggcacatg ttgagacggt agtattgatg
    40021 tcaaaagttg taccaactaa gtaaataaag tgtagaaatt atggcttatt ctaaggctat
    40081 cgttaaaagg tatcggtagt ttggagtacg ccttgttttt ttatttatct tgccaagatt
    40141 acaggattag ttgcaggtgt cttcagagat atatttgtag gaagggattt gtttttaatt
    40201 aaaacataat tctattaccc agatatattt tgaattaata tgttcacaat agtgaaaaac
    40261 aagcaataca cagagtggag gtgaaaatat ctg
//
LOCUS       DAVHSO010000013        39681 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.013, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000013 DAVHSO010000000
VERSION     DAVHSO010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 39681)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39681)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39681
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.013"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            297..1361
                     /gene="pepA"
                     /locus_tag="VVR18_000636"
     CDS             297..1361
                     /gene="pepA"
                     /locus_tag="VVR18_000636"
                     /EC_number="3.4.11.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl aminopeptidase"
                     /protein_id="HEU6032209.1"
                     /translation="MTTLFSKIKEVTELAAVSGHEAPVRAYLREKLTPHVDEVVTDGL
                     GGIFGIKHSEAVDAPRVLVASHMDEVGFMVSEIKPDGTFRVVEIGGWNPMVVSSQRFK
                     LLTRDGHEIPVISGSVPPHLTRGKGGPTMPAIADIVFDGGFADKAEAESFGIRPGDTI
                     VPDSSAILTANEKNIISKAWDNRYGVLMVSELAEALSGQKLGNELYLGSNVQEEVGLR
                     GAHTSTTKFDPEVFLAVDCSPAGDVYGGQGKIGDGTLIRFYDPGHLLLPGMKDFLLTT
                     AEEAGIKYQYYCGKGGTDAGAAHLKNGGVPSTTIGVCARYIHSHQTLYAMDDFLEAQA
                     FLQALVKKLDRSTVDLIKHY"
     gene            1383..1679
                     /locus_tag="VVR18_000637"
     CDS             1383..1679
                     /locus_tag="VVR18_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEU6032210.1"
                     /translation="MVEPNLESLIKDLYNHARHDLSEDLVAALLETTKKLPTTNEQLQ
                     AVRLSGLVNRELLLNPKHPAPELLNLARFIKREEAKYRGTATSALMYEELFKML"
     gene            2361..2804
                     /locus_tag="VVR18_000638"
     CDS             2361..2804
                     /locus_tag="VVR18_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEU6032211.1"
                     /translation="MKDSHLLAHHIRLLNGRIFQKLLSQDPEALYRGEQGKILAVLWN
                     SETGCATATDIALATGLANNTLTTMIKKLEEQKLVIVSPCGKDKRKKYLVLTELGKSQ
                     KEVGHRVSQKLDTIFYKGFSEEEIHQFEGFQERILANLKEKGNEV"
     gene            2808..3572
                     /locus_tag="VVR18_000639"
     CDS             2808..3572
                     /locus_tag="VVR18_000639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HEU6032212.1"
                     /translation="MSQQVKNAHNLYIHAIQDGRVAEAQAQSVGDTYIQHSTGVPDGK
                     EGFAAFFADFFERHPESQIKIVRTIEDGNLVFVHVHQYLNGGEAQWVTTDTFRADENG
                     RIVEHWDVVDYYRTPENDQLDQIFGDFEIKDLDKKAENKKLVRRFLTEIFQNGELEQW
                     SDYVADDLIQHNHEIGQGSAAYKNYVAEYSVTFDFVFQLLGQGNYVVSYGQTQIDGVA
                     YAQYDIFRLENGKIVEHWDNKEVMPKVEDLTNRGKF"
     gene            3587..4315
                     /locus_tag="VVR18_000640"
     CDS             3587..4315
                     /locus_tag="VVR18_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032213.1"
                     /translation="MIEYKNVALRYTEKDVLRDVNLQIEDGEFMVLVGPSGSGKTTML
                     KMINRLLEPTDGNIYMDGKRIKDYDERELRLSTGYVLQAIALFPNLTVAENIALIPEM
                     KGWSKEEITKKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKIFLMD
                     EPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVA
                     NPETILKAPATDFVADLFGGSVHD"
     gene            4308..5828
                     /locus_tag="VVR18_000641"
     CDS             4308..5828
                     /locus_tag="VVR18_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate-binding
                     protein"
                     /protein_id="HEU6032214.1"
                     /translation="MTNLIATFQDRFSDWLTALSQHLQLSLLTLLLAILLAIPLAVFL
                     RYHEKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTLPALTALVIYAIFPILQNTIT
                     GLKGIDPSLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLATLIG
                     AGGLGSFILLGIDRNNASLILIGALSSAVLAIAFNFLLKVMEKAKLRTIFSGFALMAL
                     LLGLSYSPALLAQKEKENLIIAGKIGPEPEILANMYKLLIEENTSMTATVKPNFGTTS
                     FLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQDHLAYLKP
                     MSYQNTYAVAVPKKIAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGL
                     NLNVATMQPALRYQAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMK
                     EALLKKHPELERVLNTLAGKITESQMSQLNYQVGVEGKPAEQVAKEFLQEQGLLKK"
     gene            5998..6863
                     /locus_tag="VVR18_000642"
                     /pseudo
     CDS             5998..6863
                     /locus_tag="VVR18_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000547411.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(6892..7884)
                     /locus_tag="VVR18_000643"
     CDS             complement(6892..7884)
                     /locus_tag="VVR18_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase family hexose kinase"
                     /protein_id="HEU6032215.1"
                     /translation="MILIVTLNPSIELLYFEKNFTLGAHNRFQNSTIMAAGKGINCAR
                     ALSYLGINATALTLVGGKSGEFFKQHLAQEKFHPLYIPIDGETRHSITIMHNDNIHTE
                     IVEAGPKVDQGLKSQIFDTLLQVIKEKNISIVSLNGSVHSDDRDFYNDLIQFLRENTD
                     STLKILADFSQTALQKIVNDAIHLPDFIKPNMEEFCQLTGLSVTTKQEILDYLMDKPS
                     PIPYTLVSCGEQGAIAQFNGKLYDVTAPSINLVNPTGSGDSTVAGAIYAFEQNLSDED
                     IIRYATASGTANAMENGVGVARKEIVEKLIPQVIIKEIHKSWSLGQNSSRPQKS"
     gene            complement(7901..8641)
                     /locus_tag="VVR18_000644"
     CDS             complement(7901..8641)
                     /locus_tag="VVR18_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU6032216.1"
                     /translation="MKINRKKEILNLLENSDVISYQELAQSLHVSTMTIRRDVSELEK
                     ENLVIKEHGGVRKVTFNTKTTDEKRLLYPEEKDYIAQLAANLIEPNSVIYLSAGTTIL
                     ALAKHLKNQHKHIITNSLFTFNWLNEHNFENILLTGGEFVSKTEEFHGEHAERLVKDF
                     LIDYAFLATNGLVDDHLTAFSSFGGRLQSIAMNQSRKVYLLADHSKFGLNDSYIYGKL
                     SQIDAIISDDKLDPETKKYYQQFTDIIN"
     gene            8864..9322
                     /locus_tag="VVR18_000645"
     CDS             8864..9322
                     /locus_tag="VVR18_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6032217.1"
                     /translation="MYKMMLQPDLIRLDCSVSKHTELFQMVGKELEEKGYVTNQYLEA
                     LLEREQRFPTGLKTRFLNIALPHTDPEVIKEPFIFVVRNDKDLNMLQMGDNSDTPCQN
                     FLFLGIKDPKSQVGLLAKLMEIFSQEEFVQNFAQIKDGSEMYELLNQQLS"
     gene            9350..9652
                     /locus_tag="VVR18_000646"
     CDS             9350..9652
                     /locus_tag="VVR18_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU6032218.1"
                     /translation="MARKLIVACGSGVATSTTIAEKIKTRFEDDGIDYPVEAVDYKSI
                     LNELPQASIYVYIAMPEQEVLDEAERLGVDVYPGVPFLTGMGADNVYEQIVESTNK"
     gene            9684..11033
                     /locus_tag="VVR18_000647"
     CDS             9684..11033
                     /locus_tag="VVR18_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HEU6032219.1"
                     /translation="MEIFQNVIQWILNLGSAIFVPLIIFVLGLMVGMNIKKAFISAIT
                     LGVAFTGMGMIIGFMSNAVSPASEALAINTGISLPALDLGWTGAASIVWSWGYAFAFF
                     AVQIIINIIMLSFNWTKTLNVDMWNVWGKALTGYLVYYVSGQLWAGFLVAGLQVVLEL
                     KLGDMFQKHIEDLTGIPLVTVTHGMILSAVFMLPVNKLMDKIPFLNKKADTNALRKKL
                     GIFSENSVMGFIIGVLLGFAGAYSVSNSLNLGIQVATAMALFPMVSKLFMQALSPLAE
                     SMSEFMKKRFNDREVFIGMDWPLLAGRSEVWVTLILMVPFFIGYSLILPGNAVLPIAG
                     VLNYSIAVGGLLLTGGNLARMMILGIIYLPLCLYSATYFAPILTGLANKTGAVEVEAG
                     KLITWSSLESPELRILFAESFNGNILAIGGAVAFLLLFVWLYKTMVTQEVPSKRYEN"
     gene            11023..11268
                     /locus_tag="VVR18_000648"
     CDS             11023..11268
                     /locus_tag="VVR18_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032220.1"
                     /translation="MKTSKTLWYSLLFVALVLFLLGLNSGQYLYNFLAIIISFIVYKY
                     GYSDLFREYDEKQRAKRETSEKIYHALREGKKKEENK"
     gene            11265..12017
                     /locus_tag="VVR18_000649"
     CDS             11265..12017
                     /locus_tag="VVR18_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HEU6032221.1"
                     /translation="MTSGKILFEQERRAMAEAIELTFYRKNTNTAGGNFSFKTTDVNG
                     KEYIIMTPSMMSETYHGKVSAAQVLVLDLETQEVVAGEGKPTREINLHFACYETNPDI
                     KCVFHAHAPNAMFWATSHLDMPNLSEATQKVEYIKVLDFAPNTTPELAEIVRQELLEF
                     GNKLPKEYLLDSHGILVLTPGADGEEALNKALQIIDTVEWNAEIAYKQTIFQKLGILD
                     GYYSKGRKIGDIDDLINHRPIWNQEKKDEGFE"
     gene            complement(12127..13128)
                     /gene="galR"
                     /locus_tag="VVR18_000650"
     CDS             complement(12127..13128)
                     /gene="galR"
                     /locus_tag="VVR18_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding transcriptional regulator GalR"
                     /protein_id="HEU6032222.1"
                     /translation="MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEE
                     LGYTKHLKTGESHKPKQNIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYF
                     NDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTAM
                     KQVVDYFLSQGMDRIGILTGLEETTDQEEIIQDKRLENFKNYSQARGIYHDELVFQGR
                     FTAQSGYDLMKEAIQSLGDQLPPAFFAASDSLAIGALRALQEAGISLPDRVSLISFND
                     TSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLHGRKIPSLTMLGTKLTLRESTLP"
     gene            13293..14471
                     /locus_tag="VVR18_000651"
     CDS             13293..14471
                     /locus_tag="VVR18_000651"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="HEU6032223.1"
                     /translation="MAQHLTTEVLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGG
                     HVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGV
                     LHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLDRLDLVK
                     IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTN
                     KRRELADSKYNERRAECEKAVEELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRAR
                     HAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLEHDYEVTGLELDTLVHTAWAQEG
                     VLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
                     "
     gene            14490..15971
                     /locus_tag="VVR18_000652"
     CDS             14490..15971
                     /locus_tag="VVR18_000652"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HEU6032224.1"
                     /translation="MILVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNL
                     DKLIDLKDQLVEEAVRLETIEDSQTAREILGTELMDLVTPCPSQVNRDFWETYVHYPE
                     QAIQDFYQLSQKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAAAKLV
                     QASNYPQCQLCLENEGYHGRVNHPARSNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFL
                     DGQHRPMAISRQSFERLLAIVEQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPME
                     LAPLQKTFRFAGFEQVKAGIIKWPMSVLRLTSDSKEDLINLADKIFQEWRQYSDSSVQ
                     ILAETDGTPHHTITPIARKRDGQFELDLVLRDNQTSAEHPDGIYHPHKDVQHIKKENI
                     GLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKAL
                     AIVKDSVGAIFARVLEDAGVYKQTEQGQTAFMRFVEHVGILLD"
     gene            16041..16445
                     /locus_tag="VVR18_000653"
     CDS             16041..16445
                     /locus_tag="VVR18_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HEU6032225.1"
                     /translation="MKDFHFDAISAFENYEIEKMRDGHVVVTTKVVNSSLNYYGNAHG
                     GYLFTLCDQISGLVVISLGLDGVTLQSSINYLKAGKLDDVLTIKGECVHQGRTTCVMD
                     VDITNQEGRNVCKATFTMFVTGQRSEERRVRI"
     gene            16602..17456
                     /locus_tag="VVR18_000654"
     CDS             16602..17456
                     /locus_tag="VVR18_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA adenine methylase"
                     /protein_id="HEU6032226.1"
                     /translation="MKIKEIKKVTLQPFTKWTGGKRQLLPVIRELMPKTYNRYFEPFV
                     GGGALFFDLAPKDAVINDFNAELINCYQQIKDNPQELIEILKVHQEYNSKEYYLDLRS
                     ADRDERIDMMSEVQRAARILYMLRVNFNGLYRVNSKNQFNVPYGRYKNPKIVDEELIS
                     AISVYLNNNQLEIKVGDFEKAIVDVRTGDFVYFDPPYIPLSETSAFTSYTHEGFSFAD
                     QVRLRDAFKRLSDTGAYVMLSNSSSALVEELYKDFNIHYVEATRTNGAKSSSRGKISE
                     IIVTNYEK"
     gene            17482..18252
                     /locus_tag="VVR18_000655"
     CDS             17482..18252
                     /locus_tag="VVR18_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific DNA-methyltransferase"
                     /protein_id="HEU6032227.1"
                     /translation="MTKPYYNKNKMILVHSDTFKFLSKMKPESMDMIFADPPYFLSNG
                     GISNSGGQVVSVDKGDWDKISSFEEKHEFNRKWIRLAKEVLKPNGTVWISGSLHNIYS
                     VGMALEQEGFKILNNITWQKTNPAPNLSCRYFTHSTETILWARKNDKKARHYYNYDLM
                     KELNDGKQMKDVWTGSLTKKVEKWAGKHPTQKPEYLLERIILASTKEGDYILDPFVGS
                     GTTGVVAKRLGRRFIGIDAEKEYLKIARKRLEAENETN"
     gene            18239..19105
                     /locus_tag="VVR18_000656"
     CDS             18239..19105
                     /locus_tag="VVR18_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II restriction endonuclease"
                     /protein_id="HEU6032228.1"
                     /translation="MKQTRNFDEWLSTMTDTVADWTYYTDFPKVYKNVSSIKVALNIM
                     NSLIGSKNIQEDFLDLYQNYPEILKVVPLLIAKRLRDTIIVKDPIKDFYFDFSKRNYS
                     IEEYTMFLEKSGIFDLLQNHLVSNLVDYVTGVEVGMDTNGRKNRTGDAMENIVQSYLE
                     AEGYILGENLFKEIEQNEIEEIFSVDLSAITNDGNTVKRFDFVIKNEQVLYLIEVNFY
                     SGSGSKLNETARSYKMIAEEIKAIPNVEFMWITDGQGWYKAKNNLRETFDILPFLYNI
                     NDLEHNILKNLK"
     gene            complement(19192..20454)
                     /locus_tag="VVR18_000657"
     CDS             complement(19192..20454)
                     /locus_tag="VVR18_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001194492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HEU6032229.1"
                     /translation="MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIAAALGYSAEQLT
                     YLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGAL
                     IASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
                     LSAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTP
                     LYFGMPTFEISSIVMMCIIATVSMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAV
                     LLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSS
                     VLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTA
                     FQMFFSNGIVVASLLAIVLNAVLNHKKK"
     gene            complement(20454..21035)
                     /locus_tag="VVR18_000658"
     CDS             complement(20454..21035)
                     /locus_tag="VVR18_000658"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HEU6032230.1"
                     /translation="MKLLEERILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAE
                     KFAATGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQ
                     VTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQD
                     GRDLLEKAGYPVLSLARLDRFENGQVVFKEADL"
     regulatory      complement(21435..21530)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            complement(21913..22152)
                     /locus_tag="VVR18_000659"
     CDS             complement(21913..22152)
                     /locus_tag="VVR18_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HEU6032231.1"
                     /translation="MLEEGTKDQLAELTYPFGRGVNLSFGIKDVPKLYQKVMEANYPI
                     YRPLTKRKFRVSDPYIYPHKFAVLDPDGYFLRFSE"
     gene            complement(22152..22295)
                     /locus_tag="VVR18_000660"
     CDS             complement(22152..22295)
                     /locus_tag="VVR18_000660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HEU6032232.1"
                     /translation="MDYNAVIPEFLVSNIEQSRSFYCGLLGFRIEYQRPEENFLFLLK
                     SVN"
     gene            complement(22307..23134)
                     /gene="xth"
                     /locus_tag="VVR18_000661"
     CDS             complement(22307..23134)
                     /gene="xth"
                     /locus_tag="VVR18_000661"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006596696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HEU6032233.1"
                     /translation="MKLISWNIDSLNAALTSDSARAKLSQEVLQTLVAENADIIAIQE
                     TKLSAKGPTKKHVEILEELFPGYENTWRSSQEPARKGYAGTMFLYKKELTPTVTFPEI
                     GAPSTMDLEGRIITLEFDAFFVTQVYTPNAGDGLKRLEERQVWDVKYAEYLAELDKEK
                     PVLATGDYNVAHNEIDLANPASNRRSPGFTDEERAGFTNLLATGFTDTFRHVHGDVPE
                     RYTWWAQRSKTSKINNTGWRIDYWLTSNRIADKVTKSDMIDSGARQDHTPIVLEIDL"
     gene            23268..23722
                     /locus_tag="VVR18_000662"
                     /pseudo
     CDS             23268..23722
                     /locus_tag="VVR18_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730499.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3290 family protein"
     gene            23794..24171
                     /locus_tag="VVR18_000663"
     CDS             23794..24171
                     /locus_tag="VVR18_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HEU6032234.1"
                     /translation="MKRLIDGKPTLLIKNGNIDPEACRSVGLSASDVALKLRSQGIFQ
                     MKQVKRAVQEQNGQLIVVQMGDENPKYPVVTDGVIQVDVLESIGRSEEWLLDNLSKQG
                     HDNVANIFIAEYDKGAVTVVTYE"
     gene            24377..26122
                     /locus_tag="VVR18_000664"
     CDS             24377..26122
                     /locus_tag="VVR18_000664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6032235.1"
                     /translation="MSIIQKLWWFFKLEKRRYLVGIVALVLVSVLNLIPPMVMGRVID
                     AITSGQLTQQDLLLSLFYLLLAAFGMYYLRYVWRMYILGTSYCLGQIMRSRLFKHFTK
                     MSSAFYQTYRTGDLMAHATNDINALTRLAGGGVMSAVDASITALVTLLTMLFSISWQM
                     TLVAILPLPFMAYATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQAD
                     ELKSFQAVNELTFQKNLQTMKYDSLFDPMVLLFVGSSYVLTLLVGSLMVQEGQITVGN
                     LVTFISYLDMLVWPLMAIGFLFNTTQRGKVSYQRIENLLSQESPVQDPEFPLDGIENG
                     RLEYTIDSFAFENEETLTDIHFSLAKGQTLGLVGQTGSGKTSLIKLLLREYDVDKGAI
                     YLNGHDIRDYRLTDLRSLMGYVPQDQFLFATSILDNIRFGNPNLPLSAVEEATKLARV
                     YQDIVDMPQGFDTLIGEKGVSLSGGQKQRLAMSRAMILDPDILILDDSLSAVDAKTEY
                     AIIDNLKEMRKDKTTIITAHRLSAVVHADFILVLQNGQIIERGRHEDLLAMAGWYAQT
                     YQSQQLEMKGEEDAE"
     gene            26112..27863
                     /locus_tag="VVR18_000665"
     CDS             26112..27863
                     /locus_tag="VVR18_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032236.1"
                     /translation="MQNKQEQWAVLKRLMSYLKSYGLLTFLALSFLLATTVIKSVIPL
                     VASHFIDQYLSNLNQLAVTVLLVYYGLYILQTVVQYVGNLLFARVSYSIVRDIRRDAF
                     ANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVL
                     DFRLTALVLLFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFN
                     QEKRLQAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVLMAYFGYRGFSIG
                     ITVGTMYAFIQYINRLFDPLIEVTQNFSTLQTAMVSAGRVFALIDERTYELLQENGQA
                     KVQEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYE
                     FQSGRVLLDDVDIRDFSQEELRKNIGLVLQEPFLYHGTIKSNIAMYQEISDEQVQAAA
                     AFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANID
                     SETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLTLGG
                     TYHKMYSLQAGAMAYTL"
     gene            28037..28729
                     /locus_tag="VVR18_000666"
     CDS             28037..28729
                     /locus_tag="VVR18_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000922225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEU6032237.1"
                     /translation="MLKWEDLPVEMKSSEVEFYYQLVSKRKGSLIFKRCLALVLALVL
                     LVLTSPIFLILSIWIKLDSKGPVIYKQERVTQYNRRFKIWKFRTMVMDADKKGSLVTS
                     ANDSRITKVGNFIRRVRLDELPQLVNVLKGEMSFVGTRPEVPRYTEQYSPEMLATLLL
                     PAGITSPASINYKDEDTIISQMTEKGLSADQAYVEHVLPEKMRYNLAYLREFSFLGDI
                     KIMFQTVFEVLK"
     gene            28772..29998
                     /locus_tag="VVR18_000667"
     CDS             28772..29998
                     /locus_tag="VVR18_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="HEU6032238.1"
                     /translation="MPNYNIPFSPPDITEAEIAEVADTLRSGWITTGPKTKELERRLS
                     LYTQTPKTVCLNSATAALELILHVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVD
                     IQADTLEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVENKRDLFVASSKWQK
                     AFNRIVIVSDSAHALGSTYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPAID
                     DEEMYKEFQILSLHGQTEDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYP
                     SLLQRRKDIVDRYDSGFAGSRIHPLAHKTETVESSRHLYITRVEGASLEERNLIIQEL
                     AKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYII
                     ETFKTVSEKVLTLSKK"
     gene            31128..33215
                     /gene="pfbA"
                     /locus_tag="VVR18_000668"
     CDS             31128..33215
                     /gene="pfbA"
                     /locus_tag="VVR18_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multi-ligand-binding adhesin PfbA"
                     /protein_id="HEU6032239.1"
                     /translation="MLKIVKKLEVLMKYFVPNEVFSIRKLKVGTCSVLLAISILGSQG
                     ILSDEVVTSSSPMATKESSNAITNDLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTS
                     TNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAIQDAIDAAAQGLGG
                     GNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQV
                     EWGPTEDISYSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDS
                     YQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDD
                     GKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVR
                     FTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIF
                     NIADPKTKAIRVAKDSAEYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSE
                     NSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKSNANGKEPVIRDSDGNFNIV
                     TENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNREFNSSKDNRQMNDKIDN
                     KQDNKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLL
                     LTLKGLKYYGKDK"
     gene            33199..33495
                     /locus_tag="VVR18_000669"
     CDS             33199..33495
                     /locus_tag="VVR18_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032240.1"
                     /translation="MVKINKICSIQGSSVENEDIVGSQNQYFWIIGGATDLYNSKEEI
                     GYSVSEVVHILSESLSVNCKESKTLKQIFETALLEVKDEIGLNSYELTEYSKMK"
     gene            33730..34044
                     /locus_tag="VVR18_000670"
                     /pseudo
     CDS             33730..34044
                     /locus_tag="VVR18_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996568.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
     gene            34221..34880
                     /locus_tag="VVR18_000671"
     CDS             34221..34880
                     /locus_tag="VVR18_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000793810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1868 domain-containing protein"
                     /protein_id="HEU6032241.1"
                     /translation="MKNLTKIKFKENGEFNHFPGNTVVANLYTKQDLMEVVDIIQSRY
                     RELPFIDKFTLTPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEI
                     FPLLDEEIHMRITEMGKQNILVEPADEASAKRLEEIRTYVSEKAGVCFPNHDRYQFHI
                     SIGYLRIPLTEEEEEEFTKVRAELTEILLEKIPIITVNRIDYTVFEDMRQFVPYHEKF
                     K"
     gene            34905..35972
                     /locus_tag="VVR18_000672"
     CDS             34905..35972
                     /locus_tag="VVR18_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU6032242.1"
                     /translation="MKKMKVWSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQE
                     LVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIAGAQLADRVIAEKNNAVADMVFGIGA
                     VDSNKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDAKEMPKDWT
                     ELASKYKGQYSIYGLTGGTGRAIYASILVRYLDEKGDLGVSEKGWEVAKEYFANAYTL
                     QKGESTVVKVLDKENAIQYGMIWGSGALVGQKEQNVVFKVMSPEIGVPFVTEQTMILS
                     TSKKQALAKEFIDWFGQSEIQVEYSKNFGSIPANKDALKELPEDTKKFVDQVKPQNID
                     WEAVGKHLDEWVEKAELEYVQ"
     gene            36075..37085
                     /locus_tag="VVR18_000673"
     CDS             36075..37085
                     /locus_tag="VVR18_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032243.1"
                     /translation="MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTL
                     RALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPV
                     EIYHNSQTEFVCDFIGDINVLTDETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQ
                     DFILKGTIIDVEFSGVTIHYTIKVSESQILNVTSIDSQAAIRSVGESVELFITPSDVL
                     QF"
     gene            37097..38788
                     /locus_tag="VVR18_000674"
     CDS             37097..38788
                     /locus_tag="VVR18_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU6032244.1"
                     /translation="MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSL
                     DAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGILCVLFTEYFDIKGAKILKLGYMT
                     SLIYGGVVLATGYKFVYGPYGLITKFLQNVIPSLDSNWFIGYGAVLFIMTFSGTANHT
                     LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAA
                     PMIVGGKEFQTINPMIITFAGMGNSRDLAALLAIILGIATTILLTIMNKIEKGGNYIS
                     ISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPVAIQTGNLTL
                     SNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKSRFDFLFE
                     YGALLPWLLPSTLLAVSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVR
                     AILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLSVIALNFNSLLTDFDLSVFL
                     YHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRK"
     gene            38791..39501
                     /locus_tag="VVR18_000675"
     CDS             38791..39501
                     /locus_tag="VVR18_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000127555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HEU6032245.1"
                     /translation="MTATSLGLSNIEIVVRIVLSVVIGSIIGLERGSKSQPAGIRTYS
                     IVCLAACLIMMTNEYVSYKFGTGDPTRLGAQVISGVGFLGAGTILITDKKKITGLTTA
                     AGIWASAGIGLAIGVGFYEGALLVAISVWGVISMFQPLKKYLQNRSKMIELYIVVKST
                     EAYNRVLVYCAENGIRMTDSRTAFGDVNSDRIEYFDVPDKKIASFITLELSGRFEHLR
                     LMEEIANIVGVIYVEEIS"
BASE COUNT        12303 a         6858 c         8459 g        12061 t
ORIGIN      
        1 gcgtactatt ccaaactcaa ccaactatat atttaaagaa agaagaaagg gaagtcaact
       61 attttctgta aatttcatga aaaatccaaa caactttgat ggtgtattgt ttttttgttt
      121 ggaaataaat attcgagtta attttggaat gtttactaga ttttgcacta catgcaagag
      181 aatactatcc ttttctaaga tagagcagga ctaagatact aacttagaaa tccaccttcc
      241 cactatcctt ctcctataaa aagtggtaaa atggatgaaa gaaagaagga actgaaatga
      301 caacattatt ttcaaaaatt aaagaagtaa cagaacttgc tgcagtctca ggtcatgaag
      361 cgcctgtccg tgcttatctt cgtgaaaagt tgacaccgca tgtggatgaa gtggtgacag
      421 atggcttggg tggtattttt ggtatcaaac attcagaagc tgtggatgca ccgcgcgtct
      481 tggtcgcttc tcatatggac gaagttggtt ttatggtcag cgaaatcaag ccagatggta
      541 ccttccgtgt cgtagaaatc ggtggctgga accccatggt ggttagcagc caacgtttca
      601 aactcttgac tcgtgatggt catgaaattc ctgtgatttc aggttctgtt cctccgcatt
      661 tgactcgtgg aaagggggga ccaaccatgc cagccattgc cgatatcgtt tttgatggtg
      721 gttttgcgga caaggctgag gcagaaagtt ttggcatccg tcctggtgat accatcgtac
      781 cagatagttc tgcaattttg acagccaatg aaaaaaatat catctcaaaa gcttgggata
      841 accgctacgg tgtcctcatg gtaagcgagc tagctgaagc tttatcaggt caaaaactcg
      901 gcaatgaact ctatctgggt tctaacgtcc aagaagaagt tggtctgcgt ggcgctcata
      961 cctctacaac caagtttgac ccagaagtct tcctcgcagt tgattgctca ccagcaggtg
     1021 atgtctacgg tggtcaaggc aagattggag atggaacctt gattcgtttc tatgatccag
     1081 gtcacttgct tctcccaggg atgaaggatt tccttttgac aacggctgaa gaagctggta
     1141 tcaagtacca atactactgt ggtaaaggcg gaacagatgc aggtgcagct catctgaaaa
     1201 atggtggtgt cccatcaaca actatcggtg tctgcgctcg ttatatccat tctcaccaaa
     1261 ccctctatgc aatggatgac ttcctagaag cgcaagcttt cttacaagcc ttggtgaaga
     1321 aattggatcg ttcaacggtt gatttgatta aacattatta aaccataagg gaggtggtag
     1381 ggatggtaga accaaaccta gaaagcctta taaaagatct ttacaatcat gctcgacatg
     1441 atttgagtga agatttagtt gctgctctcc tagagactac taaaaaactg cctactacaa
     1501 atgagcaatt gcaggcagtt cgtctctcag gcctggtcaa tcgtgaattg ctcctaaatc
     1561 ccaaacatcc agcacctgag ttgctcaact tggctcgctt tatcaaaaga gaagaagcca
     1621 agtacagagg aactgcgact tctgcgctta tgtatgagga actctttaaa atgctttgat
     1681 tccattgtgg atcaaagcat tttttgtaag acctatctcg tgagcgttca aatagtagta
     1741 acaaggaatc atgagaagtc agccgagact atagtagtga agaaacttct gtaatggaag
     1801 tggagcgaag tgaggaatcg tcaaacggta ggggataggc tgtttgaagg gtgctacgaa
     1861 aaagataggg caaggtgaaa ttatagcggg atgaaataag atatgaacaa attgattagg
     1921 aaaatcaaat gaatttatag aaatatttta gcagtcatag cgtcctattc cagtttcaaa
     1981 atgttataaa tacgaacaaa ttgattggga aattcaaatc gctttctatc aatgttttag
     2041 aagatacagt gccctagtct aacttcaata tactataaaa gaacagatgg aagcaattat
     2101 gatttacttc tatctttaaa ataaatggtc tgataggaaa aatgtgttcc ctcataaaat
     2161 ataggatagt acgaatggaa ggcttttgta gactggagga cgaaggagtt tagaaactct
     2221 cgttaaaagt tagttgagcc ggagtatggt ggtgtggata attatcaaaa attatttcta
     2281 aatcgaaata gttgacagtt agaacgatga gtgttacaat tgttttattc atttcgatat
     2341 cgaaataaat tggaggtgtt atgaaagata gtcatttgct agcccatcat attcgtttgt
     2401 tgaatgggcg gatttttcaa aagttactga gtcaagatcc tgaggctctt tataggggtg
     2461 aacagggcaa gattttagcg gttttatgga atagtgaaac tggctgcgca actgcgacag
     2521 atatcgcgct tgcgactggg cttgcgaata atacgctaac gactatgata aaaaagctag
     2581 aggaacaaaa gcttgtaatt gttagtccgt gtggaaaaga caagcgtaag aagtatttag
     2641 ttttaacgga gttaggcaag tcccagaaag aagtggggca tcgtgtcagt cagaaattgg
     2701 atactatctt ttacaaagga ttttcagagg aagaaattca ccaatttgaa ggttttcaag
     2761 aaagaatttt ggcgaatttg aaagagaagg gaaatgaggt ttagaatatg tcacaacaag
     2821 tgaaaaatgc tcacaaccta tacatccatg ccattcaaga cggacgagtt gctgaggctc
     2881 aagcccagtc tgtaggggat acctatatcc aacattcgac aggtgttcct gacgggaaag
     2941 aaggatttgc agccttcttt gcagatttct ttgagcgtca tccagagagt cagattaaga
     3001 ttgtccgcac cattgaggat ggcaatctgg tctttgttca tgttcatcaa tatctgaatg
     3061 gtggagaagc tcaatgggtg acgacggata ctttccgtgc ggatgagaat ggtcgtattg
     3121 ttgagcattg ggatgtcgtt gactactatc gaacacctga aaatgatcaa ctagatcaaa
     3181 tttttggaga ttttgaaatc aaggatttgg ataagaaagc agaaaataaa aagctggttc
     3241 gccgtttctt gacagaaatt ttccaaaatg gggagctaga gcagtggagt gattatgtgg
     3301 cagacgattt gattcagcat aatcatgaga ttggacaagg aagtgctgct tataaaaact
     3361 atgtggctga atatagtgtc acttttgact ttgttttcca actcttagga caaggaaact
     3421 atgtggttag ctatggtcag actcagattg atggcgttgc ttatgcccag tacgatatct
     3481 tccgtttaga gaacgggaaa attgtggagc attgggataa taaggaagtc atgcctaagg
     3541 tagaagactt gactaatcga gggaagtttt aaattgagga caaagaatga ttgaatacaa
     3601 aaatgtagca ctgcgctaca cagaaaagga tgtcttgaga gatgtcaact tacagattga
     3661 ggatggggaa tttatggttt tagtagggcc ttctggatca ggtaagacga ccatgctcaa
     3721 gatgattaac cgtcttttgg aaccaactga tggaaatatt tatatggatg ggaagcgcat
     3781 caaagactat gatgagcgtg aacttcgtct ttctactggt tatgttttac aggctattgc
     3841 tctttttcca aatctaacag ttgcggaaaa tattgctctc attcctgaaa tgaaggggtg
     3901 gagcaaggaa gaaattacga agaaaacaga agagcttttg gctaaggttg gtttaccagt
     3961 agccgagtat gggcatcgct tacctagtga attatctggt ggagaacagc aacgggtcgg
     4021 tattgtccga gctatgattg gtcagcccaa gattttcctc atggatgaac ccttttcggc
     4081 cttggatgct atttcgagaa aacagttgca ggttctgaca aaagaattgc ataaagagtt
     4141 tgggatgaca acgatttttg taacccatga tacggatgaa gccttgaagt tggcggaccg
     4201 tattgctgtc ttgcaggatg gagaaattcg ccaggtagcg aatcccgaga caattttaaa
     4261 agcgcctgca acagactttg tagcagactt gtttggaggt agtgttcatg actaatttaa
     4321 ttgcaacttt tcaggatcgt tttagtgatt ggttgacagc cctatctcaa catttgcagt
     4381 tgtcactttt gaccttgtta ctagctattt tgcttgcgat tcccttggct gtttttcttc
     4441 gctatcatga gaagctggcc gactgggtct tgcagattgc aggtattttc cagaccatcc
     4501 cgtctctggc cttgttgggg ctctttatcc ctttgatggg aattgggacc ttgccggctt
     4561 tgacagctct agtgatttat gcgatttttc cgattttaca aaatactatt actgggctga
     4621 agggaattga tccgagtctt caagaggctg ggattgcctt tgggatgacc agatgggagc
     4681 gtctcaagaa gtttgaaatt ccacttgcca tgcctgttat catgtctgga attcggacgg
     4741 cagcggtctt gattatcggt acggctacct tggcgacctt gattggggca gggggactgg
     4801 gttcctttat cctgttggga attgaccgta ataatgccag tttgattttg attggggccc
     4861 tttcttctgc agtgctagct attgccttta acttcctact aaaagtaatg gaaaaagcga
     4921 aattgcggac gattttctct ggttttgcct tgatggcttt attactgggt ctgtcttata
     4981 gtccagccct tttggctcaa aaagagaagg aaaacttgat tattgctggg aaaataggcc
     5041 cagaaccaga aattttggct aatatgtata aattgctgat tgaagaaaat accagcatga
     5101 ctgcgactgt taaaccgaat tttgggacga caagtttcct ttatgaagct ctgaaaaaag
     5161 gtgatattga catttatcct gaatttaccg gtacggtgac tgaaagtttg cttcaaccat
     5221 cacccaaggt gagtcatgag ccagagcagg tttatcaagt ggcgcgtgat ggcattgcca
     5281 agcaggatca tctagcctat ctcaaaccta tgtcttatca aaatacctat gctgtagctg
     5341 ttccgaaaaa gattgctcaa gaatatggct tgaagaccat ttcggatttg aaaaaagtgg
     5401 aagggcagct gaaggcaggc tttacgcttg agtttaacga ccgtgaagat ggaaataagg
     5461 gcttgcaatc aatgtatggt ctcaatctca atgtggcgac tatgcagcca gctcttcgtt
     5521 atcaggcaat tcagtcaggg gatattcaaa tcacggatgc ctattcgact gatgcggaat
     5581 tggagcgtta tgatttacag gtcttggaag atgacaagca actcttccca ccttatcaag
     5641 gggctccact catgaaagaa gctcttctca agaaacaccc agagttggaa agagttctta
     5701 atacattggc tggtaagatt acagaaagcc agatgagcca gctcaactac caagtcggtg
     5761 ttgaaggcaa gccagcagaa caagtagcca aggagtttct ccaagaacaa ggtttgttga
     5821 agaaataaaa ggagaggaat gtcagaggta gccactttct tccctagaca aaagagcctg
     5881 ggacaatagt ctcttatctc caaaaaaagc aacggatttg ccgttgcttt ttttgcatgg
     5941 ttacgatagt cttggtaaaa tagaattgct taataaacca tttaaaaagg ctatcccatg
     6001 catattcact ataacacaaa tcaaacaact ttaccactag aaatcagttc cttcttacca
     6061 caagaccatc tcgtctttac tattgaaaaa gtggtgaata ccttggagga acgtcacttc
     6121 tacacctcct atcatgcctt tgatcgcccg tcttatcacc ctaaaatgct tgtatctact
     6181 cttctatttg cctattcaca agggattttc tctggtcgaa aaattgaaaa atggaagagt
     6241 tagtgacctt agattgtttg tttattgacg gaactaagat tgaagccaat gccaacaagt
     6301 atagttttgt gtggaagaaa acgacagaga aattctccgc caaacttcaa gaacagatac
     6361 aagtctattt tcaagaagaa atcactcccc ttctgattaa atatgccatg tttgataaga
     6421 aacaaaagag agggtataaa gagtcagcta aaaactgagc gaattggcac tataatgaca
     6481 aggaggatag ctacatacat cctgatggct ggtgctatcg ttttcaccat atcaagcacc
     6541 agaaaacaca gacagacttt caacaggaaa tcaaggttta ctacgctgat gaacctgaat
     6601 cagcccctca aaaaggactg tatatgaacg aacgctatca aaacttgaaa gctaaagaat
     6661 gtcaggcgct tttatctccc caaggtagac agattttcgc tcaacgcaag attgatgtga
     6721 aacctgtctt tgggcagata aaggcttgtt tgggtcacaa gagatgtaat ctgaggggca
     6781 agcgtcaagt gagaattgac atgggattgg tacttatggc caataacctc ctaaaataca
     6841 ataagagaac gactcaaaat taaaaagcta gagttccaca attggaaatc tctagctttt
     6901 ttgtggtcga gaactatttt gtcccaggct ccatgattta tggatttctt taataataac
     6961 ttgagggatt aatttttcca caatttcttt tcttgcgact cctacaccat tttccatagc
     7021 atttgcagtt ccactagctg tagcatagcg aatgatatcc tcgtccgata agttctgttc
     7081 aaaagcatag atagctcctg ctacagtaga gtctcctgac cctgttggat tgaccaaatt
     7141 aatggatggt gcagtgacgt cgtataactt accgttaaac tgggcgatgg ctccttgctc
     7201 tccacaagac actagagtgt atgggatagg agaaggcttg tccatcaagt agtctaatat
     7261 ttcttgctta gtggtgacag ataatcctgt taattggcaa aattcttcca tatttggttt
     7321 gataaagtca ggaaggtgta ttgcatcgtt aacaattttt tgtagggcag tttgtgaaaa
     7381 atcagctaat atttttaatg tagaatcagt gttttcacgt aagaattgaa tcaaatcatt
     7441 atagaaatcc ctatcatctg aatgtacaga gccatttaaa gagacgatgc tgatattctt
     7501 ttccttgata acctgtaaca atgtatcaaa gatttgtgat tttaaacctt ggtccacttt
     7561 tgggcccgcc tcaacaattt ccgtatgaat attgtcatta tgcatgatgg ttattgagtg
     7621 acgagtctct ccgtcaatag gaatatataa ggggtgaaac ttttcttgtg caagatgttg
     7681 tttgaaaaac tcgccagatt taccaccgac tagggttagt gcagtggcat ttattcccaa
     7741 ataagagagg gcacgagcac agttgattcc tttaccagcg gccataattg tagaattttg
     7801 gaaacgatta tgagcaccta gtgtaaagtt tttttcgaaa tagagtaatt cgatagatgg
     7861 atttaatgta acgatgagaa tcatgggcag atacctttct ttagttaata atatcggtaa
     7921 actgctgata atatttcttg gtttctggat ctaatttgtc atctgaaata atagcatcta
     7981 tttggctaag ttttccataa atataggaat cgtttaggcc aaatttagaa tgatcagcta
     8041 gtaaataaac ttttctagat tgattcatag caatagattg taaacgtcca ccaaaagatg
     8101 aaaaagctgt taaatgatca tcaacgaggc cattggttgc taagaatgca tagtcgatta
     8161 gaaaatcttt tactagtctt tcagcatgct caccatggaa ctcttccgtt tttgaaacaa
     8221 actctccgcc agttaggagt atattttcaa agttgtgttc atttagccaa ttaaaagtaa
     8281 acaagctatt cgttataata tgcttatgtt gatttttcag atgtttagca agtgctaaaa
     8341 tagtagttcc agcgctaaga tagatgacac tatttggctc aattaaatta gcagcaagtt
     8401 gcgcgatgta atctttttct tcaggataaa gcagacgctt ttcatcagtt gttttcgtat
     8461 tgaatgttac ttttcgaaca ccgccgtgtt ctttgataac tagattttct ttttctaatt
     8521 ctgaaacatc tcttcgaatg gtcattgttg agacgtgtaa tgattgcgca agttcctgat
     8581 aggagatgac atcgctgttt tcaagcaaat ttaaaatttc tttttttcta ttaattttca
     8641 aaataaaggt tgctcccctc agtgaatttt atagtactat cataacataa aattagaaaa
     8701 gattagaatc taataagttt ataacaaaaa atatcaaaag ataacaaaaa ataacaatta
     8761 aagcattgac tttttaaatg aaaacgctta taattacatt ataacaaaaa ataacagaat
     8821 gttaacaata aatttaacgt ttttttaaaa aaggagttgt gatatgtata aaatgatgtt
     8881 gcaaccggat ttgatacggt tggactgtag tgtatcgaag catacagaac tattccaaat
     8941 ggttggaaag gagttggaag aaaagggata tgtaacaaat caatacttgg aggctctatt
     9001 agaaagggaa cagcgttttc ctacaggctt aaaaacacga tttttaaata tcgcacttcc
     9061 ccacacagat ccagaagtca tcaaggagcc atttattttt gttgttcgca atgataaaga
     9121 cttaaatatg ttgcaaatgg gtgataactc tgatactcct tgtcaaaact ttctgttctt
     9181 aggtataaaa gatcctaaga gccaggttgg tctcttagct aaactaatgg aaattttttc
     9241 tcaagaagaa tttgtacaaa acttcgctca aataaaagat gggtcggaaa tgtatgaatt
     9301 attaaatcaa caactatcat aaacaaaagc ctaaaaagga gaataaaaaa tggcaagaaa
     9361 attaatcgta gcatgtggaa gtggtgtagc aaccagtaca acaattgctg aaaaaatcaa
     9421 aacacgcttt gaagatgacg gtatcgacta tcctgtagaa gcagtagatt acaaatcgat
     9481 cttaaatgaa ctaccacaag caagtatcta cgtctatatt gctatgccag aacaagaagt
     9541 tttggatgaa gccgagagac tgggggtaga tgtttatcca ggtgttccat tcttaactgg
     9601 aatgggtgcg gataacgtat atgagcaaat tgttgagtct acaaataaat aaaatataaa
     9661 aataaattaa ggagaaaaag gttatggaaa tctttcaaaa tgttattcag tggattttga
     9721 atttaggatc tgcgattttt gtaccattga taattttcgt tttaggttta atggttggta
     9781 tgaatattaa aaaagccttt atttcagcca ttactctcgg ggttgccttt acaggtatgg
     9841 gaatgatcat tggatttatg tcaaatgcgg tgtcgccagc ttctgaggct ctagctataa
     9901 atacaggaat ttctctccca gctcttgact tgggttggac tggtgcggca agtattgtat
     9961 ggtcatgggg ttatgccttc gcattctttg ctgtacaaat cattatcaat attattatgc
    10021 tcagtttcaa ctggacaaag actcttaatg tggatatgtg gaatgtttgg ggtaaagcct
    10081 taacaggata tcttgtttac tatgtcagcg gtcagttgtg ggctggtttc cttgtggcgg
    10141 gattacaagt tgtgttagag ctaaagcttg gagacatgtt ccaaaaacat attgaggatt
    10201 taactggtat tccgctggta actgttacac atggtatgat tctttccgcg gtattcatgt
    10261 tgcctgttaa caaattgatg gacaaaattc cattcttgaa taaaaaagct gatacaaatg
    10321 ctcttcgtaa aaaattgggt atcttctctg aaaactctgt aatgggattc attattggtg
    10381 tgcttctcgg atttgcaggt gcctattctg tatctaattc cttaaatttg ggtatccaag
    10441 ttgcgactgc gatggcgcta ttcccaatgg taagtaaact cttcatgcag gccctttcac
    10501 cactggctga atctatgagc gaattcatga agaaacgctt taatgaccgt gaagtattta
    10561 ttggaatgga ctggccattg ttagcaggtc gctcagaagt ttgggtaacg ttaatcttga
    10621 tggtaccatt ctttattggc tattctctta tcttgccagg aaatgcagtg ctcccaattg
    10681 caggtgtctt gaactactct atcgctgtag gcggactatt gctgacaggt ggtaacttgg
    10741 cacgtatgat gattctaggt attatttatc ttccgctttg tctctacagt gctacttatt
    10801 tcgcaccaat cttgacaggg ttggccaata agaccggagc agtcgaagtt gaagctggta
    10861 aattgattac ttggtcatca cttgaatcgc cagaattgcg gattctcttc gcagaaagct
    10921 ttaatggtaa tattttagcc atcggagggg cggttgcttt cctattactt tttgtatggt
    10981 tgtacaaaac aatggtaaca caagaagtac cgtcaaaacg ttatgaaaac tagtaaaact
    11041 ctttggtaca gtctcttatt tgtagctctt gtcttatttt tgctaggttt aaatagtggc
    11101 caatatcttt acaatttttt agcgattatc atcagtttta tcgtctataa atatggctac
    11161 agtgacttat ttagagaata tgatgagaaa caacgtgcga agagagagac atctgaaaaa
    11221 atctatcatg ctttacgaga aggaaaaaag aaagaggaaa ataaatgaca agtggtaaaa
    11281 ttttatttga acaagaaaga cgcgctatgg ctgaagccat cgaactgact ttctatcgca
    11341 aaaacaccaa tactgctgga ggaaatttct cctttaaaac gacagatgtt aatggtaaag
    11401 aatacatcat tatgacaccg tccatgatgt ctgaaaccta tcacgggaaa gtatcggctg
    11461 ctcaagtgtt ggtgctggat ttagaaactc aagaagtggt tgctggagaa ggcaaaccga
    11521 cacgcgaaat caaccttcac tttgcttgct atgaaaccaa cccagatatc aaatgtgttt
    11581 tccatgctca tgcaccaaat gcaatgtttt gggcaactag ccacttagat atgccaaact
    11641 tatctgaagc tactcaaaaa gttgagtata tcaaagtttt ggattttgcc ccaaatacta
    11701 cacctgaact ggctgaaatt gtacgtcaag aactcctaga gtttggcaac aaattgccaa
    11761 aagaatactt actagacagt catggtattt tggtattgac accgggtgct gatggagaag
    11821 aggctttgaa taaagccctt cagattattg atacagttga atggaatgct gaaattgcat
    11881 acaagcagac aatcttccaa aagttaggaa ttttggatgg ttactattct aaaggtcgta
    11941 aaattggaga tattgatgat ttaatcaatc atcgtccaat ttggaatcaa gaaaagaaag
    12001 acgaaggttt cgaataaact atttgggagg aggataggca cgtgctatct tcctttttaa
    12061 aaaagaaatc ctaatggata tttgagaatc tctattagga tttttggtct tattatatta
    12121 gttgagttat ggcagagtac tttctcttaa cgtcagtttg gttcccaaca tggtcaggct
    12181 aggtattttc cgaccgtgga gtacttcctt gttaagaata tccatacctg ctcgccccat
    12241 ttcttcagta taaactgtaa tactagagag gggaggatag acctgtttgg tcagactggt
    12301 gtcgttgaat gaaatgaggc tgacgcgatc tggcaggctg attccagctt cttggagggc
    12361 acggagggca ccgatagcta aactatcgct ggctgcgaaa aatgctggcg gaagttggtc
    12421 tcccaagctc tgaatggcct ccttcattaa gtcatagcca gactgggcag taaatcttcc
    12481 ttgaaagacc agttcatcat gatagattcc cctcgcttga ctgtagtttt tgaagttttc
    12541 tagacgcttg tcctgaatga tttcttcttg gtctgttgtt tcctcaagcc ctgttagaat
    12601 cccgatgcgg tccatccctt gactgaggaa ataatcgaca acctgtttca tagcagtgta
    12661 aaaatccgtg ataatacagg tatgtcccag ggaaagtgta tcgctgtcta gaaatacaag
    12721 aggcttttgg tattcttcaa aggcagaaat ctgagctcga ctaaactttc cgatgcagag
    12781 aatcccaatc acttcctcgc ttaaggtaaa aggatggtca ttaaaatagc gcaagatatc
    12841 atagtccaac tcttgggctc ttttttctat tcctaggcga atctggtagt agtagaggtc
    12901 gtctagctcc ccttgttcgc tgacccattg gataatggca atattttgct tgggtttgtg
    12961 ggactcgcct gtcttgaggt gcttggtgta gcccagctct tcagcaacgg ttaaaatacg
    13021 gtgtctggtt tcttctgtaa cagataggct ctggtcgcgg ttgaggacac gggatacggt
    13081 cgcgattgag acagaggcta gctgtgcaat gtcttttaag gtagccataa atcctccttg
    13141 attaggttag tatatcatat ttttcttctt tttactgata ttttagtaaa attttagtaa
    13201 aaaggattga ccttgggaaa ttccttggat acaatagaaa gaaaacgatt acacgttaag
    13261 atggcttaac ggacagtcaa aggagaattc atatggcaca acatcttact actgaagtcc
    13321 ttcgcaaaga ctttcttgct gtttttggtc aagaagcaga ccaaaccttc ttttcaccag
    13381 gccgtattaa tttgattggt gaacacacag actacaacgg tgggcacgtt tttcctgctg
    13441 ctatttcctt gggaacttac ggtgcagctc gtaagcgtga cgaccaagtc ttgcgtttct
    13501 actcagctaa ctttgaggac aagggcatta tcgaagtgcc tctcgctgac ctcaagtttg
    13561 aaaaagagca caactggacc aattatccaa aaggggttct tcatttcttg caagaagctg
    13621 ggcacgtgat tgacaaaggt tttgattttt atgtttatgg gaatatccca aatggtgctg
    13681 gcttgtcttc ttcagcatcc ttggagctct tgacaggagt cgtggcagag catctctttg
    13741 atttaaaact agaccgtttg gatttggtta aaatcggaaa acaaacagaa aataacttta
    13801 tcggagtcaa ctctggtatc atggaccagt ttgctattgg tatgggggct gaccaacgtg
    13861 ctatttactt agataccaat actttagaat acgacttggt gccacttgat ttgaaggaca
    13921 atgtcgttgt tatcatgaac accaacaaac gccgtgaatt ggcggactct aaatacaatg
    13981 aacgtcgtgc tgagtgtgaa aaagcagtgg aagaattgca agttgccttg gatattcaga
    14041 ccctgggtga attggacgag tgggccgttg accaatatag ctatttgatt aaagatgaaa
    14101 atcgtttgaa acgtgctcgc catgctgtgc ttgaaaacca acgtaccctt aaagctcaag
    14161 cagcccttca agcaggtgat ttggaaacat ttggtcgttt gatgaatgcg tcacacgttt
    14221 ctctggagca tgattatgaa gtaactggtt tggaattgga tactcttgtt cacacagctt
    14281 gggcacaaga aggagttctc ggtgctcgta tgacaggggc tggttttggt ggctgtgcta
    14341 ttgccttggt tcaaaaagat actgttgagg cctttaagga agctgtaggc aaacactacg
    14401 aggaagtagt tggatacgct ccaagcttct atatcgctga agttgcaggt ggcactcgcg
    14461 tccttgacta gtcaaaagga ggctctatag tgatcttagt agataaattt gtaacacatg
    14521 tcatttctga aagttcattt gaggaaatgg atcgaatcta cctgaccaac cgtgttttgg
    14581 cacgagtggg agaaggtgtt ttggaagttg agaccaatct ggataaattg attgacctca
    14641 aggaccagct agttgaggaa gccgttcgat tagagacgat tgaggatagt cagactgcgc
    14701 gtgaaatcct tggtactgaa ctgatggact tggtgactcc ttgtccgagt caggtcaatc
    14761 gtgacttctg ggaaacctat gtccactatc ctgagcaagc gatacaggat ttttatcaac
    14821 tcagtcagaa aaatgactac atcaaactca aggccattgc taaaaatatc gcttatcgtg
    14881 ttccatctga ttatggagaa cttgaaatta ccatcaatct ctctaagcct gaaaaggatc
    14941 cgaaagagat tgcggcagcc aagttggtgc aagctagtaa ttatcctcag tgtcaacttt
    15001 gtttagagaa tgagggttac catggtcggg tcaaccaccc agctcgcagc aaccaccgga
    15061 ttatccgttt tgaaatggtt ggtcaggaat ggggtttcca gtattcgccc tatgcttact
    15121 ttaatgagca ttgtatcttt ttagatggcc agcatcgtcc catggccatt agtcgtcaga
    15181 gttttgaacg tctgttggct atcgtagagc agtttccagg atattttgct ggatctaatg
    15241 ccgacctgcc gattgtgggg ggctctattc taactcatga tcattatcag ggaggccgtc
    15301 acgtatttcc tatggaattg gctcccttgc aaaagacctt ccgatttgct ggttttgagc
    15361 aggtcaaggc tggaattatc aagtggccaa tgtctgtcct acgcttgact tcggattcca
    15421 aagaggattt gattaactta gctgataaga ttttccagga atggcgtcag tattcagatt
    15481 ctagtgtgca gattttagca gagacagacg ggacaccgca tcacaccatc acaccaatag
    15541 cgcgtaagcg tgatggacag tttgagttgg acttggtctt gcgagacaat cagacttcag
    15601 cagagcatcc tgatggcatc tatcatcccc acaaggatgt ccaacatatc aagaaggaaa
    15661 atatcggctt gattgaggtc atgggcttgg caatcttgcc accacgtctg aaagaagaag
    15721 tagagcaagt cgctagctat cttgtaggag aagctgttac agttgccgat tatcatcagg
    15781 agtgggcaga ccaactcaaa tcccaacatc cagacctaac ggataaagaa aaagcccttg
    15841 caatcgtcaa ggactctgtg ggtgctatct ttgcgcgtgt acttgaggat gcaggagtct
    15901 acaagcagac agaacaaggg cagacagcct ttatgcgctt tgtggaacat gtcggaattt
    15961 tactagacta ggagctttct ccttgcacag tcctataaaa agtagtatca tagtgtcatt
    16021 tgaaatatca ggaggaaacg atgaaagact ttcattttga cgctatatct gcctttgaaa
    16081 attacgaaat tgaaaaaatg agagatggtc acgttgtggt gacgaccaaa gtagtgaact
    16141 cgtcgctcaa ctactatggc aatgcccatg gtggctatct attcacacta tgtgaccaaa
    16201 tcagtggttt ggtggttatc tcgctgggac ttgatggggt gacactccaa tcctctatca
    16261 actaccttaa ggcaggaaaa ctcgacgatg tattgaccat taaaggagaa tgtgtccatc
    16321 aaggtcgtac aacctgtgtg atggatgtgg atatcaccaa tcaagagggc agaaatgtct
    16381 gcaaagcaac ctttactatg tttgtcacag gccaaaggtc tgaggaaaga cgggtaagga
    16441 tataaagagt aatttaatag agtgaggtga attttggaat ttataagatt tgccttactc
    16501 atttttttat attgatatga tttaattcta aaatagaaaa tttagtaatg tggtagaaaa
    16561 tacaagagtt gtgttttaat ttctatggta taattaaaag catgaagata aaagaaataa
    16621 agaaagttac tttacaaccg ttcacgaaat ggacaggtgg taaaagacaa ttattgcctg
    16681 ttattagaga attaatgcct aaaacctata acaggtattt cgaacctttt gttggaggtg
    16741 gagctttatt ttttgatttg gctcctaaag atgcagttat taatgatttt aacgctgaac
    16801 taataaattg ctatcaacaa attaaggaca atcctcaaga attgattgaa attttgaaag
    16861 ttcatcagga atataattca aaagaatatt atttagattt acgttctgca gatcgtgatg
    16921 aaagaataga tatgatgtcc gaagtacaaa gagctgcacg tattctatat atgttgagag
    16981 tgaactttaa tggtctatat cgtgtgaatt ctaagaacca atttaatgtt ccatatggac
    17041 gttataagaa tcctaaaatt gttgatgagg aattgatatc tgctatttca gtttatctaa
    17101 ataacaatca actagaaatt aaagtgggag attttgaaaa ggcaattgta gatgttcgaa
    17161 caggagattt tgtgtatttt gaccctccat atattccatt gtctgagacg agtgcattta
    17221 cgtcttatac tcatgaggga ttctcttttg cagatcaagt aagattaaga gatgccttta
    17281 agagattgag tgatacagga gcttatgtta tgttatcaaa ttcttctagt gctttagtag
    17341 aggagttgta taaggatttt aatatacatt atgttgaagc tacccgaact aatggagcaa
    17401 aatcttcaag tcgaggaaaa atttctgaaa ttatagtcac aaattatgaa aaataacgaa
    17461 tataagtatg gaggtgttct tatgacaaaa ccatactaca ataaaaataa gatgattctt
    17521 gttcattcag atacgttcaa gttcttatca aaaatgaaac cagaaagtat ggatatgatt
    17581 tttgctgatc caccttattt tttaagtaat ggtggaatat ctaattctgg gggacaagtt
    17641 gtttctgttg ataaaggaga ttgggataaa atttcttcat tcgaagaaaa acatgagttt
    17701 aatcgtaaat ggattcgcct agcaaaagaa gttctgaagc ctaatgggac ggtatggatt
    17761 tcaggtagtt tgcacaacat atactcagtt ggaatggcat tagaacaaga aggttttaaa
    17821 attctgaata atattacttg gcagaaaaca aaccctgccc ccaatttatc ttgtcgttat
    17881 tttacccatt ctactgaaac cattttatgg gccagaaaaa atgataaaaa agctcgtcat
    17941 tactacaatt atgatttaat gaaagaattg aatgatggaa aacaaatgaa agatgtctgg
    18001 acgggttctt taacaaagaa agttgaaaaa tgggctggga aacatccaac tcaaaaacca
    18061 gagtatttgt tagaacgcat tattttagcc tctactaaag agggtgacta tattctagac
    18121 ccatttgttg gtagtggcac tacgggtgtt gttgcgaagc ggttaggtag aagatttata
    18181 ggtatcgatg ctgaaaaaga atatttaaaa attgcaagga agaggttgga ggcagaaaat
    18241 gaaacaaact agaaattttg atgagtggtt gtcaacgatg accgacacag tagctgactg
    18301 gacttattat acagattttc ccaaggttta taaaaatgta tctagtataa aagttgctct
    18361 aaatattatg aatagtctta ttggtagtaa aaatatacaa gaggattttt tagacttata
    18421 tcaaaattat ccagaaattt tgaaagttgt gcctctactt attgctaaac gtttgagaga
    18481 tacgattatt gttaaggatc cgataaaaga tttctatttt gattttagta aacgaaacta
    18541 tagtattgaa gaatatacta tgtttttgga aaaatcaggt atatttgatt tattgcaaaa
    18601 tcatttagta tcaaatttag ttgactacgt tacaggtgtt gaggttggta tggatactaa
    18661 tgggcgcaaa aatcggactg gagatgcgat ggaaaatatt gttcaaagtt atcttgaagc
    18721 tgaagggtat attttaggag agaatttatt taaagagatt gaacaaaatg aaatagagga
    18781 aattttttct gtcgatttat ctgctattac gaatgatggg aatactgtga aacgttttga
    18841 ttttgtcata aaaaatgaac aagtgcttta tctgattgag gttaattttt attcaggaag
    18901 tggttcaaaa ttaaatgaga cggctagatc ttacaaaatg attgctgaag aaattaaagc
    18961 tattcctaat gttgagttta tgtggattac tgatggacaa ggttggtata aggctaagaa
    19021 taatttacga gaaacatttg atattttacc attcttatat aatattaacg atttggaaca
    19081 taatatttta aagaatttga aataggtcca attcaattag atgggaattg ggattgattg
    19141 tatttataat caatttgtga taaacaaaaa agaggctcgc acctcttttt cttatttctt
    19201 tttatgattt aatacggcat tgaggacaat ggcgagtagg ctggctacga cgattccgtt
    19261 tgagaagaac atttggaagg ctgtcggcat gctgacaaag agattactgt tgttgagacc
    19321 gacacctgca gcgattgaaa cagctgcgat aaggaagttg tgttcattgt tagcaaagtc
    19381 aactcgggct aggatttgca tcccttgaat agatacaaaa ccaaacatca ccagcatggc
    19441 accgccgagg acggagcttg gaatgatttg ggcaagggca ccaaacttag gaagcagtcc
    19501 aaggagaacc aggaaaccag ctgcgtagta gattggcagg cgttttttga tgcctgacaa
    19561 tttaaccaaa ccaacgtttt gtgaaaatcc ggtgtaaggg aaggtgttaa agattcctcc
    19621 gagaagtacg gccaaacctt ctgcgcggta accgttgcga aggcgcgtgc tgtcgattgg
    19681 atcttttgtg atatcagaca aggctagata aacaccagtt gactcaacca tagacaccgt
    19741 tgcgatgata cacatcatga caatagatga gatttcaaag gttggcatcc caaagtagag
    19801 tggagttggg acatggacaa gtggagctac cgcaacagga gagaagtcca ccaagcccat
    19861 agtagcagca atggcagttc caacaaccag accaatcaaa atagagatag acttgataaa
    19921 tcctttggta aagatgttga tcaagaggat aatcagaaca gtaatagctg aaagcaagag
    19981 actttgacca gttggctctg gaacgttatt tcccatattt ccaatagcga cagggatcaa
    20041 ggttaaacca atcgtggtaa taacagatcc tgttacgata gaggggaaga gattggccac
    20101 ttttgagaag atgcctgaaa caagaaccac gtaaatccca gatgcgataa gggcaccaaa
    20161 catagcgcca ctaccatggc tttgcccaat cataatcaag ggagcgaccg actggaatgc
    20221 aactccaaga acgactggga gtccaatccc aaagtatttg ttgagttgga gttggaggaa
    20281 ggttgccacc ccacacatga agatatctgt agaaatcagg taggtcaact gctcagctga
    20341 atagccaagg gctgccgcaa tcatgatggg aaccaggata gatcctgagt acatggctag
    20401 taagtgctgc aagccaagaa cggctgcttg cgagtgtttt tcttgagttt gcattagaga
    20461 tctgcctcct taaatacgac ctgaccattt tcaaaacgat ccaaacgagc aagtgatagg
    20521 acagggtagc ctgctttttc aagcaaatca cggccatctt ggaaggattt ctcaatcacg
    20581 ataccgatag cttggactgt ggcaccggcc tgttcgatga tttgaatcaa gcctttagca
    20641 gcttggccat tagcaaggaa atcgtcgata atcaaaacct tatcttctgg tgagaggaat
    20701 tttccagcga tagaaacggt gctggtcacc tgtttggtaa aggagtagac ttgagcagtt
    20761 aagatgcctt cgttcatggt gatgttctta gcttttttgg cgaaaatcat gggaacgttt
    20821 aaggcttcag ctgtaaaaac ggctggggca atacccgacg cttcaatggt tacgaccttg
    20881 gtaatgccag tagcagcaaa tttttccgca aaaaccttac caatctctcg catcaagcta
    20941 aagtcaactt ggtgggttaa aaaggaatct accttgagga tgttatcacc caagatatgc
    21001 ccatccttga ggatgcgctc ttctaataat ttcataagac ctcctaaagt ctaaaagtta
    21061 atttacttgt tgtttaaata tttctatagt gatccctttt gctaatacta tatatttgat
    21121 aaaactatta cgagcgaagc gagtcttatc aaatatttcc cgttgtagtg gtatcataga
    21181 caatgatctt gttattgtct atgacgggat ttttgagagt aaaatagttc ggggaactat
    21241 tttagcctaa gcctagaaat gaaagagcta ggggctcaaa aattagggat gaaattccct
    21301 ggattcctga aattattcac aggataattt cacctctcgt ccgcactaat taagggaaat
    21361 attaaaaata ttcaaaaaag acctacttaa tctctaagta agtcccctaa atagacatgg
    21421 caaaaacggc catatctcac tgctgactta cttattgtta ggtgttccgg caccttgtag
    21481 aaacgtcgtg ccaattcacg acataaacaa gtaaaacgat attcaatttt aaataggctt
    21541 gagccaatgt ttttatttta cactaaataa ctttagaaat caactatttt gttagtgttt
    21601 tggtttaaaa aacgaacaaa cagaagagag ggtgaacaaa aactccgttg taagctaaca
    21661 tttatactaa atgaaaatca aagagcaaac taggaagcta tccacaacct caaaacactg
    21721 ttttgaggtt gtggatagaa ttgacagagt cagtatcata tacctacggt aaggcgatgt
    21781 tgacgtggct tgaagagatt ttcgaagagt attagaagat ttttccatca taaaaggcat
    21841 actatcaagt ttttagacac ctgacaatat gcctttttct aactttaaag acttttccca
    21901 atttttatta ttctactcgc taaatcttaa aaaatagcca tctggatcca aaactgcaaa
    21961 tttatgagga tagatatagg gatcactgac acgaaacttt cttttggtca agggacgata
    22021 aataggatag tttgcctcca tcactttttg atagagtttt ggaacatcct ttatgccaaa
    22081 ggagagattg actccacgac caaaggggta ggtcagttca gctagttgat cctttgttcc
    22141 ctcctctaac attagttgac actcttcaag agaaagagaa agttttcttc tggacgttgg
    22201 tattcaatcc taaaacccag taaaccacag tagaaggacc gggactgttc gatattcgat
    22261 acaagaaact cgggaatgac cgcattgtag tccatataga aaatccttac aagtcaattt
    22321 ccaagacaat cggtgtatgg tcttggcgag cacctgagtc aatcatatca gatttagtga
    22381 ccttgtcagc gatacggtta cttgtgagcc agtagtcgat tctccagcct gtattgttga
    22441 ttttagaagt tttgctgcgt tgtgcccacc aagtgtagcg ttcaggaaca tcgccatgaa
    22501 catggcggaa ggtatcagta aatccagttg ccaataggtt ggtaaatcca gcacgttcct
    22561 cgtcagtaaa tccaggtgaa cggcggttgc tagcaggatt tgcaaggtcg atttcattgt
    22621 gggctacgtt gtagtcaccg gtcgcaagga ctggtttttc tttgtctagt tcagccaaat
    22681 actccgcata tttgacatcc cagacttggc gttcttccaa gcgtttaaga ccatcgccag
    22741 catttggtgt gtaaacttgg gtcacgaaaa atgcatcaaa ttctagagtg atgatgcggc
    22801 cttccaagtc catggtagaa ggggcaccga tttctgggaa agtgacagtg ggtgtaagtt
    22861 ctttcttata aaggaacatg gttccagcat agcctttacg ggcaggctct tgggaagagc
    22921 gccacgtgtt ttcgtagcct gggaagagtt cttctaaaat ttccacgtgt ttctttgtag
    22981 gtcctttggc agaaagcttg gtttcttgga tagcaatgat atcagcattt tcagcgacca
    23041 aggtttgtag gacttcttgg gacaatttgg cacgagctga gtcactagtt agggcagcgt
    23101 ttagggaatc aatattccat gagataagtt tcataaagtt acctttttca ttcagattat
    23161 agattttatt ataccaaaaa aagatctatt tccccaacgt atggtttgaa aaattactct
    23221 ctttcgttta taattaagaa tgattttatg aaagggagtg aaaatacatg aaattctact
    23281 cttatgacta tgtactcagc caaatcggtc agcaaaatgg tatcatggtt ggctttggga
    23341 ttgttctatt agctgtgaca gtttttttgc tttcaaggca taccatgata aaaaggaacc
    23401 gaatttcgtg agttggtcat gatttcagct ctggccttat ttagctctgc ttttggtcag
    23461 catcacgact tatcaaaaca atcaagtttc taacaataaa tttcaaactt cacttcattt
    23521 catcgaggtt gtttccaaag atttgggagt agacaagtca gaagtctatg ttaatacttc
    23581 cacaaacaca gatggcgcac ttatcaaagt gggagatcgc tattatcgtg ccctaaacgg
    23641 aagtgagcca gacaagtacc tgttagagaa agtcgaattg tataagacag acgcaattga
    23701 actggtggat gtgaacaaat gacacttaat tatatcgaaa ttttaatcaa actggtcttg
    23761 actctcaaat agctcaacaa caatgttcac tttgtgaaac gtttgattga tggtaagcca
    23821 actctcctta tcaaaaatgg gaatattgac ccagaagcct gtcgttcagt tggtttgtct
    23881 gcatcggatg tagccctcaa acttcgtagc caagggattt tccagatgaa gcaagtcaaa
    23941 cgagctgtgc aagagcaaaa tggacaactt atcgttgtgc aaatgggaga tgaaaatcct
    24001 aagtatccag ttgtgactga cggtgtgatt caagtagatg tcttggaatc gattggtcgt
    24061 agcgaagagt ggttgcttga taacctcagt aaacaagggc atgacaatgt agccaatatc
    24121 tttattgctg aatatgacaa gggtgctgtt acagtcgtaa cttatgaata agaaaaacct
    24181 ggggtcttgt actcttcgaa aatctcttca aaccgcgtca acgtcgcctt gccgtatgta
    24241 ggttactgac ttcgtcagtt ctatctacaa cctcaaagca gtgctttgag cagcctgcgg
    24301 ctagtttcct agtttgctct ttgattttca ttgagtattg gcctcaggtt tccatttgca
    24361 atcagaaagg gattttatgt ccattattca aaaactctgg tggtttttca agttagaaaa
    24421 acgccgttat ctagtcggaa ttgtggccct ggtcttggtt tccgtcctca atctcattcc
    24481 tcctatggtt atggggcgag tcattgatgc catcacatcg gggcaattaa cccagcagga
    24541 cctccttctt agcctatttt acttgctact tgcagccttt ggtatgtact atttgcgcta
    24601 tgtgtggcgt atgtatatcc ttgggacctc ttattgcttg ggacagatca tgcggtctcg
    24661 cttgtttaag catttcacaa aaatgtcgtc agccttttat caaacctatc ggacgggtga
    24721 tctgatggca cacgcaacca atgatatcaa tgccttgact cgtttagcag gtggcggtgt
    24781 catgtctgcg gtggatgcct ctatcacggc tctggtgact ttgttgacca tgctctttag
    24841 catctcatgg cagatgactc ttgttgccat tctcccccta cctttcatgg cctatgcgac
    24901 tagtcgccta gggagaaaga ctcataaggc ctttggcgaa tcccaagctg ctttttctga
    24961 actcaataac aaggtacagg agtccgtatc aggtatcaaa gtgaccaagt ctttcggtta
    25021 tcaggcagac gagttgaagt cttttcaggc agtcaatgaa ttaaccttcc aaaagaacct
    25081 gcaaaccatg aaatatgata gtctctttga ccctatggtt ctcttgtttg ttggttcgtc
    25141 ctatgtttta acgcttttgg ttggctcctt gatggttcag gaagggcaga ttacagttgg
    25201 taatctagtc acctttatca gctatttgga tatgctggtc tggcctctta tggccatcgg
    25261 cttcctcttt aatactactc agcgagggaa ggtttcttac cagcggattg aaaatctttt
    25321 gtctcaggaa tctcctgtac aagaccctga gtttcctctg gatggtattg aaaatgggcg
    25381 tttggagtat accattgaca gctttgcttt tgaaaatgag gaaacactga cggatattca
    25441 ctttagtttg gcaaaagggc aaacactggg cttggttggg cagacaggct ctgggaaaac
    25501 gtccttaatc aagctcctct tgcgtgaata cgatgtggat aagggtgcca tttatctaaa
    25561 cggtcacgat attcgggact atcgtctgac agaccttcgc agtctcatgg gctatgttcc
    25621 tcaggaccag tttctctttg caacttcaat cctagacaat atccgctttg gcaatcctaa
    25681 cttgcccctt tcagcggtcg aggaagctac taagctagcc cgagtttacc aagatattgt
    25741 agacatgcct caaggatttg atacgctgat tggtgaaaaa ggagtcagtc tttctggtgg
    25801 tcaaaagcaa cggttggcta tgagtcgggc tatgatttta gaccctgata tcttgatttt
    25861 ggatgattcc ttatccgccg tagatgccaa gacagagtat gcgattatcg acaacctcaa
    25921 ggagatgcga aaggacaaga caaccattat cactgcccat cgcctcagtg ctgttgtcca
    25981 tgcagatttt attttagttc tacaaaatgg tcaaattatc gaacgaggca ggcacgaaga
    26041 cttgctagcg atggctggct ggtatgccca aacctaccag tctcagcagt tggaaatgaa
    26101 aggagaagaa gatgcagaat aagcaagaac agtgggctgt attgaagcgc ttgatgtctt
    26161 atctcaagtc ttatggactc ctgacctttt tggcactcag ttttctccta gcgacgacgg
    26221 tcattaaaag tgtcataccc ctcgtggctt cccactttat cgaccagtat ctcagcaatc
    26281 ttaaccaact agccgttacc gttttgctgg tctactatgg tctctacatc ctacaaactg
    26341 tagttcagta tgtcggcaat cttctctttg cgcgcgtgtc ttacagtatt gttagggata
    26401 ttcgtcggga tgcctttgcc aatatggaga aactgggcat gtcttacttt gacaagacgc
    26461 cagcaggttc tatcgtttct cgtttgacca acgataccga gacgattagt gatatgtttt
    26521 ctgggatttt atctagcttt atctcagcag ttttcatctt tctgacaact ctttatacca
    26581 tgttggtatt ggattttcgt ttgacagcat tagtcttgct ctttctcccc ttgattttcc
    26641 ttttggtcaa tctctatcgg aaaaaatcag tgaaaatcat tgagaaaacc agaagtctct
    26701 tgtcagatat caatagtaag ctggcagaga atatcgaggg aatcaggatt attcaggcct
    26761 ttaatcaaga gaagcgcctg caggcagaat ttgatgaaat caaccaagaa cacttggtct
    26821 acgccaaccg ttctgtagcc ttggatgccc tctttttgag acctgccatg agtttgctga
    26881 aacttctagg ctatgcagtc ttgatggcct actttggcta ccgtggtttt tctatcggga
    26941 taacggtcgg gaccatgtat gcctttatcc agtacatcaa ccgccttttt gaccccttga
    27001 ttgaggtgac gcaaaacttt tcaactctgc aaacggctat ggtttctgca ggtcgtgtct
    27061 ttgccctgat agacgagagg acctatgaac ttcttcaaga aaatgggcaa gccaaagtcc
    27121 aagaaggcaa tatccgtttt gaacatgtgt gtttctcata tgacggtaaa catccgattc
    27181 tggatgacat ttctttctct gttaataagg gtgaaaccat tgcctttgta ggtcatacag
    27241 gttcagggaa atcgtctatt atcaatgtcc tcatgcgctt ttatgaattc cagtcaggga
    27301 gagttctctt ggatgatgtg gatatcaggg atttcagtca agaagagctg agaaaaaaca
    27361 tcggtttggt cttgcaggaa cccttcctct atcatgggac tattaagtcc aatatcgcca
    27421 tgtaccaaga aatcagtgat gagcaggttc aggctgcggc agcctttgtg gatgcagatt
    27481 cctttattca agaacttcct caggggtacg actcccctgt ttccgagcgt ggttcgagct
    27541 tctctactgg gcaacgccag cttcttgcct ttgctagaac agtcgccagc cagcctaaaa
    27601 tcctgatttt ggatgaagcg acagccaata ttgactctga aacagaaagc ttggttcaag
    27661 cttctctggc gaagatgaga cagggccgaa caactattgc tatcgctcac cgcctttcta
    27721 ctattcaaga cgccaactgc atctatgtct tggataaggg acgcattatc gagagtggaa
    27781 cccatgagga actcttgact ctgggaggaa cctatcacaa gatgtatagt ttgcaggcag
    27841 gggccatggc ctatactctt tgaaaatctc tttaaaccat gtcagcttta tctgcaatct
    27901 caaagctgta ctttgatttt cattgagtac tagaaggaaa tccttcaaat tacagatttc
    27961 tttcaccgca ttttccattt tgtggtataa tgaaaaatgt tgacaaatag tataataaaa
    28021 acaaaggaga aaccgcatgc tgaaatggga agacttgcct gtggaaatga aatcaagcga
    28081 ggttgagttt tactaccagc ttgtctctaa aaggaagggg tcgctgattt tcaagcgttg
    28141 cttggccttg gttttggcct tggtcttact ggttctgacc tctcccatct ttctcatctt
    28201 gagcatttgg atcaagttgg atagcaaggg gccagtgatt tacaagcaag agcgtgtgac
    28261 ccagtacaac cgtcggttca agatttggaa gttccgtacc atggtgatgg atgcggataa
    28321 aaaaggaagt ctggtgactt ctgctaacga tagccgcatt accaaggttg gaaatttcat
    28381 ccgacgtgtt cgtttggacg aactgcctca gttggtcaat gtccttaaag gtgagatgtc
    28441 ctttgtcggt acacgacctg aagtgccacg ttatacagag cagtacagcc ctgaaatgct
    28501 ggcaaccttg ctcttgccag cagggattac ctctccagcc agcatcaact acaaggatga
    28561 ggacaccatc atcagtcaaa tgacggagaa aggtctgtca gctgatcagg cctatgtgga
    28621 gcatgttctt cctgaaaaga tgcgctataa cctcgcctat ctccgagagt ttagtttcct
    28681 tggggacatc aaaatcatgt ttcaaaccgt gtttgaggta ctaaaataaa gtagtcataa
    28741 gaaaatgagt acagataaaa ggagaaaagc aatgccaaat tacaatattc cattttcacc
    28801 gcctgatatc acagaagcag aaattgctga agtagcggat accctgcgtt ctggttggat
    28861 cacaacaggt cctaaaacaa aagaactgga gcgccgcttg tctctttaca cacagacacc
    28921 taagactgtc tgtctcaact ctgcgacagc cgctctggag ttgattttac acgttttgga
    28981 agtgggacct ggtgatgaag tcatcgttcc agccatgacc tataccgctt catgtagtgt
    29041 cataactcac gtgggagcaa ctcctgtcat ggtggatatc caagcagata cgcttgagat
    29101 ggactatgac ctgctggagc aagccatcac tgaaaagaca aaggtgatta tcccagtaga
    29161 gcttgcaggg attgtttgtg actatgaccg tttgttccaa gttgtggaaa acaaacgtga
    29221 cttgtttgtt gcttcaagca agtggcaaaa agcctttaac cgtattgtaa ttgtctctga
    29281 tagtgcccac gctttgggat ctacttataa aggacaacct tctggttcta tcgctgactt
    29341 tacttccttc tcattccacg ccgttaagaa ctttacaacg gccgaaggtg gaagtgcgac
    29401 ttggaaggcc aatccagcga ttgatgacga agagatgtac aaggaattcc aaatcctttc
    29461 ccttcacggg caaactgagg acgctcttgc caagatgcaa ctggggtcat gggaatacga
    29521 tatcgttaca ccagcctata agtgcaacat gaccgatatc atggcttcac ttggtttggt
    29581 acaattggac cgctatccaa gtttgttgca acgccgtaag gacattgtgg accgctatga
    29641 tagtggtttt gcaggttctc gcatccatcc tttggcacac aagactgaaa ctgtcgaatc
    29701 ttcacgccac ctctacatca cccgtgtaga aggagcaagc ctagaagaac gcaacctcat
    29761 catccaagaa ttggctaaag caggaattgc aagtaatgtt cactacaaac cgcttcctct
    29821 cttgacagcc tataagaatc ttggatttga tatgacgaac tatcctaagg cctatgcctt
    29881 ctttgagaat gaaattaccc tccctcttca tactaaatta agcgatgaag aagtagacta
    29941 tatcattgag actttcaaaa cagtttctga aaaagtgcta actttatcaa aaaaatgaca
    30001 aactacagtc aagcgaaagt gatcctgtcc ctaaaaagtc taattgagtg taaaaactgt
    30061 tgttttcaat tgataatagt ttacacctgt agttgaggcc tctctctcct cagagagaga
    30121 atttttatag gattttcctt tcttgtggga gtcccgtggt ttgaaataag atgtgagcaa
    30181 tttggtgtag catttagaat ccttactaga catcatttag aaaatctagt gtcttgttct
    30241 agtttttaat tcaccctatt ttttgaaaga cgtgagtttc catgagtgag attgtggaaa
    30301 ctcgcgtctt tttttgtttt cagaatattg ttcaaagttt tgtgcctgtc tttcatgttc
    30361 tagtcattct tttgcatgat agaatttata gcatattgat attataataa tacaaatatt
    30421 ctatatgttt agtgatgctt gctatacatc attagatctc ccgcgagaca atctataaaa
    30481 cacttgtcta cgattaccta tatgccctat tccagtattt tagaagcact gcatctattt
    30541 ttatcgaggt taaatctagc ttttatagaa ggtctattta agaaatatat tgtagtgttt
    30601 tagtttcaat ccgccatatg agcgatattc aggtaaatat ccctggcaaa tgcttgtatg
    30661 acaagatatt tgttctttca tttataattt acaacatatc aacaaattta aatatagtaa
    30721 atgggatatt ttatattcaa gctaagaaag atagcatcac ttttgaatgg aaggctaaag
    30781 agcaaactag gaagttggcc atagatagct caaaaccctg ctttgaggtt gtagatatag
    30841 taaaatgaaa taagaatagg acaaatcgat cgggacagtc aaatcgattt ctaacaatgt
    30901 tttagaagta gaggtgtact attatagttt cagtctacta tagaactgac caagtcagta
    30961 acctagactt agggcaaggc ggcactgacc tagtttgaag agatttccga agagtataaa
    31021 ttttaatatt ttcttgtgtt attccttgac aattcaattt ggaaaatata tgataaagat
    31081 aatgacagcg gtgtcattct atctgtttta agaaaagtaa taatcaattg ttaaaaatag
    31141 taaaaaaatt ggaggttctg atgaaatatt ttgttcctaa tgaggtattc agtattcgta
    31201 aattaaaggt ggggacttgc tcggtactat tggcaatttc aattttggga agccaaggta
    31261 ttttatcgga tgaagttgtt actagttctt caccgatggc tacaaaagag tcttctaatg
    31321 caattactaa tgatttagat aattcgttaa gtgttaatag tatcagctct aatggtacta
    31381 ttcgttccaa ttcacaatta gacaacagaa cagttgaatc tacagtaaca tctactaatg
    31441 aaaataagag ttataaggaa gatgttataa gtgacagaat tatcaaaaaa gaatttgaag
    31501 atactgcttt aagtgtaaaa gattatggtg cggtaggtga tgggattcat gatgatcgac
    31561 aagcaattca agatgcaata gatgctgcag ctcaagggct aggtggagga aatgtatatt
    31621 ttcctgaagg aacttattta gtaaaagaaa ttgttttttt aaaaagtcat acacacttag
    31681 aattgaatga gaaagctaca attctaaatg gtataaatat taagaatcac ccttccattg
    31741 tttttatgac aggtttattt acggatgatg gtgcgcaagt agaatggggc ccaacagaag
    31801 atattagtta ttctggtggt acgattgata tgaacggtgc tttgaatgaa gaaggaacta
    31861 aagcaaaaaa tctaccactt ataaattctt caggtgcatt tgctattggg aattcaaata
    31921 acgtaactat aaaaaatgta acattcaagg atagttatca agggcatgct attcaaattg
    31981 caggttcgaa aaatgtatta gttgataatt ctcgttttct tgggcaagcc ttacccaaaa
    32041 cgatgaagga tgggcaaatc ataagtaagg agagcattca gattgaacca ttaactagaa
    32101 aaggttttcc ttatgccttg aatgatgatg ggaaaaaatc tgaaaatgtg actattcaaa
    32161 attcctattt tggcaaaagt gataaatctg gggaattagt aacagcaatt ggcacacact
    32221 atcaaacatt gtcgacacag aacccctcta atattaaaat tttaaataat cattttgaca
    32281 acatgatgta tgcaggtgta cgttttacag gattcactga tgtattaatc aaaggaaatc
    32341 gctttgataa gaaagttaaa ggagagagtg tacattatcg agaaagcgga gcagctttag
    32401 taaatgctta tagctataaa aacactaaag acctattaga tttaaataaa caggtggtta
    32461 tcgcagaaaa tatatttaat attgccgatc ctaaaacaaa agcgatacga gttgcaaaag
    32521 atagtgcaga atatttagga aaagtatcag atattactgt aacaaaaaat gtaattaata
    32581 ataattctaa ggaaacagaa caaccaaata ttgaattatt acgagttagt gataatttag
    32641 tagtctcaga gaatagtata ttcgggggta aagaaggaat tgttattgag gattcaaagg
    32701 gtaaaataac cgttttaaat aaccaatttt ataatttatc cggtaagtat atatcattca
    32761 tcaaatctaa tgcaaatggg aaagaacctg ttatacgtga tagcgatggt aatttcaata
    32821 ttgtaacgga gaatgggctt tacaaaattg taacaaataa tttaagtgat aaaaacgaaa
    32881 aagaaaaaaa caaagaggaa aaacaatcta attcaaataa tgtaattgat agtaaccaga
    32941 agaacagaga gtttaactca agtaaagata atagacaaat gaatgacaag atcgacaata
    33001 aacaagataa taagacagaa gaagtaaact ataaaatagt tggagatggc agagaaactg
    33061 aaaatcatat taataaatct aaagaaatag tagatgtaaa acaaaaatta ccaaagactg
    33121 gttcgaacaa gattatggaa ctattcttaa cagtgacagg aattggttta cttttgacac
    33181 taaaagggtt gaagtattat ggtaaagata aataaaattt gttcgataca aggaagttcc
    33241 gtagaaaatg aggatattgt aggttcacaa aatcagtatt tttggattat tggtggagct
    33301 acagatttat ataattctaa agaggagata ggttattcag tctcagaagt tgtacatatt
    33361 ttatcagaaa gtttgtcggt taattgtaaa gaatcaaaaa ctcttaaaca aatatttgaa
    33421 actgctttac tcgaggttaa agatgaaatc ggtttaaact catatgaatt aacagagtat
    33481 agtaaaatga aataataata ggacaaatca atcaggacag tcaaatcgat ttctaacaat
    33541 gttttagaag tagatgtgta ctattctagt ttcaatatac tatattatcg cttaccaata
    33601 tttgctaaac tttcagaaaa aagttggagt atatgatgct aggtgactgc gtcatgttag
    33661 taaacgaaat ggaaataact gatcatagag tagataactt atttgaaaaa gggaaaaatg
    33721 agataaaaga tccatgtagt agatttagca ataggacata taaaagcttt agaaaaagta
    33781 tctgaaaaaa cagatgttta tatctataac ctaggctcgg gagaaggcac tagtgtatta
    33841 caacttgtaa atacatttga aagtgttaat aagatcccta ttccttataa aatagttcca
    33901 agacgttcag gagacgttgc aacttgttat gcaaatgcag acaaagcata taaggaatta
    33961 aattggagga caacaaaatc gattgaagac atgtgtagag atacatggaa ttggcaatca
    34021 aaaaatccca atgactataa ttgatgatac tgtctatatg agtgctgtat tttggaaaaa
    34081 ttacttaacc ttttaatgaa atgcatattt aatgaaagat aaataaaaaa agtttgacag
    34141 cgcttgacaa aggaaacggt ttcattgtat aatgtaaaca tggtgacacc gatgtcaaat
    34201 ataaaaaaga aggtctttat atgaaaaact taacaaaaat taagttcaaa gaaaatgggg
    34261 aatttaatca tttccctggg aatacagttg tagcaaatct ttatactaaa caagatttga
    34321 tggaagttgt tgatattatt caatcacgtt atagagaatt accatttatc gataagttta
    34381 ctttaactcc aaggaattct attcacatga ctgtaattga attgttgtgc catgaaaatc
    34441 gtgaaacgga gttttggagc agtaatcttc ctctagatac acctttacag gaaatacatg
    34501 attactttgc taaacaactt gaaatttttc cattgttgga tgaagaaatt catatgcgta
    34561 taactgaaat gggaaaacaa aacatactag ttgaacctgc agatgaagct tctgcaaaga
    34621 gattagaaga aattcgtact tatgtctcag aaaaagcagg tgtttgtttc cctaatcatg
    34681 atagatatca attccatatt tcaattgggt atcttcggat tcctctaacc gaagaggagg
    34741 aagaagagtt tactaaagtc agagcagaat taactgaaat tttattagag aagattccaa
    34801 ttattactgt aaaccgtatt gactatactg tatttgaaga tatgagacaa tttgttccat
    34861 atcacgaaaa atttaaataa aataataaaa aaggagaact tatcatgaaa aaaatgaaag
    34921 tttggtctac tgtacttgca acgggagttg ctcttactac acttgctgct tgctctggag
    34981 gttcaaattc tacgactgct tcttcatctg aagaaaaagc tgataaaagt caagaattag
    35041 taatctattc gaactcagtc tcaaatggtc gtggtgattg gttaactgct aaagcaaaag
    35101 aagctggttt taatataaaa atggttgata ttgctggcgc tcaattagca gaccgtgtta
    35161 ttgctgagaa gaataatgca gttgcagata tggtatttgg aattggtgct gttgactcaa
    35221 ataaaattag agatcaaaaa ttactagtac agtacaagcc taaatggtta gataaaattg
    35281 atcaatcttt atcagataaa gataattatt ataacccagt tattgttcaa cccttggtat
    35341 tgattggagc tcctgatgca aaagaaatgc caaaagactg gacagagtta gctagtaaat
    35401 ataagggaca atattccatt tatggcttaa ctggtgggac tggacgcgcc atttacgcaa
    35461 gtattctagt tcgttatctt gatgaaaaag gtgatttagg agtatcggaa aagggctggg
    35521 aagttgcaaa agaatacttt gcaaatgcct atacactaca aaaaggtgaa agcacagttg
    35581 ttaaagtatt agacaaagaa aacgctatcc aatacggtat gatctggggt tctggagcgt
    35641 tagtcggaca aaaagaacaa aatgttgttt ttaaagtgat gtctcctgaa attggggttc
    35701 catttgtaac tgagcaaaca atgattttga gtacaagtaa gaagcaagca ttggctaaag
    35761 aatttattga ttggtttggt caatctgaaa ttcaagtaga gtacagtaaa aactttggct
    35821 ctatccctgc caataaagat gccctcaaag agctaccaga agatactaag aaatttgttg
    35881 atcaagtgaa accacaaaat attgactggg aagctgttgg aaagcatttg gatgaatggg
    35941 tagaaaaagc tgaattagaa tacgtacaat aagaaataag agttattatt tatgtccaag
    36001 tctctctatt atttctaaat ttatggaaga aataaagaga ggcttttggt ttagtaatag
    36061 agggagttag tgagatgatt aaatttgata atattcaaat taaatatggt gattttgttg
    36121 caattgataa tctgaattta gatatacatg aaggggaatt ctttacattt cttgggcctt
    36181 caggatgtgg taaatcaact actttgagag cattagtagg ttttttagat ccatcatcag
    36241 gaagtattga agttaatgga acagatgtca ctcatttgga acctgaaaag cgtggaattg
    36301 gtattgtatt tcaatcttat gcgctatttc caactatgac tgtttttgat aatattgcat
    36361 ttggtttaaa agttaagaag gtagctccag atgttattaa agctaaagta tcagcagtgg
    36421 cagcaaaaat taagatctct gatcaacagt tacagcgtaa tgtatcagaa ttatctgggg
    36481 gtcaacaaca aagggtagca ttggctcgtg ctctggttct tgaacctaaa attctttgtc
    36541 tagatgaacc attgtcaaac cttgacgcaa aattacgtgt agatttgaga aaagagttga
    36601 aaagacttca aaaagagtta ggtattacta ctttatatgt tactcatgat caagaggaag
    36661 ccttgacttt atctgataga attgcagtct ttaacaatgg atacatcgaa caggtcggta
    36721 caccagtaga gatttatcat aattctcaaa ctgaatttgt atgtgatttt attggagata
    36781 ttaatgtttt gaccgatgaa acagtccacg aagtattatt gaaaaataca agcgttttct
    36841 tagaggataa aaaaggatac attcgattag agaaagttcg attcaatcgt gaaactgaac
    36901 aagattttat tctaaaaggg acaattattg atgttgagtt ttctggagtt acaattcact
    36961 atacaataaa agtttctgaa agtcagattc ttaatgtaac aagtattgat agtcaggctg
    37021 ctattagatc tgtcggagaa agtgtggaat tatttatcac accatcagac gttctgcaat
    37081 tttaaggagg tgcagtatgc gtcataaatt aaatttaaaa gattggctta ttcgtttagg
    37141 gttaatctgg ttcttagtaa catttattat ttatccaaac tttgatctag tagtgaatgt
    37201 atttgtaaaa ggaggagaat tttcccttga tgctgtacat cgtgttctaa aatctcagag
    37261 ggcacttcag agtattatga acagttttaa gttagcattt tcacttatta ttacagttaa
    37321 tgtcgtaggt attctttgtg ttctatttac agagtacttt gatattaaag gtgctaaaat
    37381 tttaaaatta ggttatatga cctctttaat ttatggagga gtggttttag cgactggata
    37441 taaatttgtc tatggtcctt atggattgat tacaaaattt ttacaaaatg ttatcccttc
    37501 tttagactct aactggttta ttgggtatgg tgcagtctta ttcattatga cattttcagg
    37561 aactgctaat catacattgt ttttaacaaa tacaattcga agcgttgact atcacactat
    37621 tgaggctgct cgaaatatgg gagcaaaacc atttactgtt ttccgaaaag tagtgttacc
    37681 aaccttaatt ccaactctat ttgcacttac tattatggtt tttcttagtg gtttatctgc
    37741 agtagcagca cccatgattg ttggtggtaa agaatttcaa actataaatc caatgattat
    37801 tacatttgca gggatgggga attctcgtga tttagctgcc ttacttgcaa ttattttagg
    37861 tattgcaact acaattttgc ttactatcat gaataagata gaaaaaggtg gaaattatat
    37921 ttctatctct aagactaaag cgcctctaaa aaaacaaaaa attgcgtcta agccttggaa
    37981 tatcattgct cacattgtag catatggatt gttcacagtt ttcatgcttc cactaatttt
    38041 tatagtatta tactcattta cagatccagt tgcaattcaa acaggtaact taacattatc
    38101 aaactttact ttagaaaatt atcgcttatt ctttagtaat agtgcggcat tctctccatt
    38161 cttggtcagc tttatttatt ctattattgc tgcgacaaca gcaacaattc tcgcagttgt
    38221 atttgctcgt gttgtcagaa aacataaatc tcgttttgat ttcttatttg aatatggtgc
    38281 tctacttcct tggttactac caagtacact tttagcagta agtttattat ttacttttaa
    38341 tcaaccacaa tttcttgtct tgaatcagat tttggtaggt agtttggtaa ttctacttat
    38401 tgcatatata gttgtaaaaa tcccattttc ttatagaatg gtacgtgcta ttttatttag
    38461 tgttgatgat gagatggaag atgcagcaag aagtatgggt gcttcacctt tttatactat
    38521 gatgaaggtt atcattccat ttattttacc ggttgttctc tctgttattg ctttaaactt
    38581 taactcttta ttaactgact tcgacttatc tgtattcctt taccatcccc tagctcaacc
    38641 attaggtatt acgattcgat ctgcaggtga tgaaacagca acatctaatg cacaagctct
    38701 ggtatttgtt tatacaattg ttctgatgat tatttctgga acggtattat acttcacaca
    38761 aagaccgggg cgtaaagtaa ggaaataatc atgacagcca ctagtcttgg gttatcaaat
    38821 attgaaatag ttgtcaggat tgttttatca gtagtcattg gtagtataat tggtttagag
    38881 agagggagca aatcccagcc tgcaggcatc cgaacttata gtattgtttg tctagctgca
    38941 tgtttgatta tgatgacgaa tgaatacgta tcttataaat ttgggacagg agatcctaca
    39001 cgattaggag ctcaagttat atcaggtgtg ggttttctag gcgctggaac gattcttatt
    39061 acagataaaa agaaaattac aggtctgaca actgcagcag gcatttgggc ttcggcagga
    39121 attggattag ctattggagt aggtttttat gagggagctc ttttagtagc catttctgtt
    39181 tggggtgtga tatccatgtt ccaaccacta aaaaaatatc tgcaaaatcg ttctaaaatg
    39241 attgaattgt atatagtagt taaatctaca gaagcctata atcgtgtatt ggtttattgt
    39301 gcagaaaatg gtatcagaat gaccgattca agaacagcgt ttggagatgt taattctgac
    39361 agaattgaat actttgatgt tccggacaaa aaaatagcgt catttattac tctggaatta
    39421 tcaggtagat ttgaacatct tcgactgatg gaagaaattg ctaatattgt aggtgttatt
    39481 tatgtcgaag aaattagctg aaatttagta aacaaaggga cagatgtttt tgtccttttg
    39541 ctttttagat gttttaatca tctaattttt gagtagattt ttgctcagag gtttttatga
    39601 aagattataa aatcaatttt gatttaggta aaatagaata ttttgataat aattgtttga
    39661 tacaagtata caaatttatt t
//
LOCUS       DAVHSO010000014        39093 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.014, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000014 DAVHSO010000000
VERSION     DAVHSO010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 39093)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39093)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39093
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.014"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            66..230
                     /locus_tag="VVR18_000676"
     CDS             66..230
                     /locus_tag="VVR18_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000508323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YczI family protein"
                     /protein_id="HEU6032246.1"
                     /translation="MGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGIALV
                     LAAVWLGWPK"
     gene            309..1037
                     /gene="yaaA"
                     /locus_tag="VVR18_000677"
     CDS             309..1037
                     /gene="yaaA"
                     /locus_tag="VVR18_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HEU6032247.1"
                     /translation="MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLES
                     FYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHV
                     FITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSS
                     EFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARR
                     LNFAGFVYREDLSQPQGLVFVKEV"
     gene            complement(1088..2572)
                     /locus_tag="VVR18_000678"
     CDS             complement(1088..2572)
                     /locus_tag="VVR18_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003096885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6032248.1"
                     /translation="MRNLLSTKVQRQLRLMETLIQNRNWMKLHELAEKLGCTERILKS
                     DLNELRIAFPSINIQSSVNGIMIDLEVNTSVEDIYQYFLANSQSFQLLEYMFFNEGLP
                     IYRTIENLYFSSANLYRLGRNITKVLSSQFQIELSFTPSEIRGNEIDIRYFFAQYFSE
                     RYYFLDWPFPDLPEEDLTEFADFFYKITNYPMRFSIYRMYKLMIAISIHRVKNGHFID
                     LPNHFYKEYYPLLKSIPNFQETLAYFSKHFGLEMTPDTIAQIFISFLQNDIFLDPQEF
                     FNSLEDNSQARYSYQLLSQILERLSKQYKITFTNHDELIWHLHNTAFFERQEIFSTPI
                     LFEQKALTIKKFEVYFPDFMGSARQELAQYRQAIGQHDHPEQLEHLMYTILTHAENLS
                     TQLLENRPPIKVLIISNFDHAISLTFVDMLSYYCNNRFTFDIWDELKTSPEILNQTDY
                     DIIVSNFYIPGITKKFICRNHLSIMNLVNHLNTLSNEIHLSNTL"
     gene            2788..9477
                     /locus_tag="VVR18_000679"
     CDS             2788..9477
                     /locus_tag="VVR18_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU6032249.1"
                     /translation="MKHSHKKSFDWYSMQQRYSIRKYYFGAVSVLLGTALVLGAAASV
                     QTVQAEENKQETTNSISVGRGEAATKPAEVSASNKEKTYAAPTVANPVETTPVKTGEV
                     TKPAEKVEEAKNKKEEVTHQDAIDKSKLLTALSRAKKLESKLYTEASAANLQTSIQAG
                     QSLLGKADASEAELSAAESSIQSSIIGLELRSNSNKGTVSETPVAKKANIVEAKEETN
                     PAATTDRSAVDSAVLPTSTAAKVETTSAPASINEILKPGLSLSDARQNPAIRKEDVDR
                     GYSGFRAAPAPTNQPVTNLGNNTVFTDISRGSHTFRGNGNSRRGNPIHFDVTTTRVRN
                     RVDFSIRYSGPGEFVNNNFILDKGNGFGEPSRATVSTPKLRDQVKNISKGGNFVSHSG
                     YSLEAAVETSTNQTIKFSLPIANPNGDLSVRLRPVTFNVGQGESGSATSNDPYSNSNY
                     YFREKPLLLDANPNGGTNNKTVSEDIDFQTVYLPTSKLPEGQTRLVREGEKGQRQITY
                     KVHRFGNETVLGLPISNRVTKEAKPRIMQIGVAKELIDTVKPRVDQNKVGDTNNLTFY
                     LDNDGNGVYTEGVDELVQKIAIKDGAKGEKGDQGERGLTGAQGAKGEKGARGERGLTG
                     AQGAKGEKGDRGERGLTGAQGAKGEKGDRGERGLTGAQGAKGEKGDQGERGLTGAQGA
                     KGEKGAQGERGLTGAQGAKGEKGDRGERGLTGAQGAKGEKGAQGERGLTGAQGAKGEK
                     GDQGERGLTGAQGEKGARGERGLTGAKGEKGAQGQAGRDGVTPTVTVKDNKNDGTHTI
                     TINDGRGNVTSTVVRDGFDGASPLVATQRNDADKTTTVIFYYDKNGNNELDASDKKLK
                     EVVIADGAKGEKGDKGEQGLQGRDGEQGPKGEDGKTPTVKVTDGQDGTHTITINDGKG
                     GITTTVVRDGFDGASPLVSTHRNEADKTTTVIFYYDLNDNNQFDEGDTKLKEVVIADG
                     KQGPKGDKGADGAKGEKGDQGERGLTGSKGEKGDQGERGLTGAQGAKGDKGEQGLQGR
                     DGAQGPKGADGQRGPAGPQGPKGEQGNPGTPGKDGKSLIAVKNGTETKVYVEDPARPG
                     QPLNPNQPLATITDGRNGTNGQSPTITATRSVQNGKNGVLVTITPVGGRPQTTFVEDG
                     QKGADGKTPTVTITEGQNGTHTLTVHNPGSPDVTTTIRDGATGQAGRDGKDVLNGKVN
                     PQPNQGKNGDKYINTETGDVYVKNNGNWDKEGNIKGPKGDKGADGAKGEKGDQGERGL
                     TGAQGAKGADGAVGRDGRDGKDVLNGKANPEAHQGKDGDKYVNTETGDVFVKNNGNWD
                     KEGNIKGPKGDKGADGAKGEKGDRGERGLTGAQGAKGADGAAGRDGRDGRDGKDVLNG
                     KVNPEANQGKDGDKYVNTETGDVFVKNNGNWDKEGNIKGPKGDKGERGEDGKTPEVTV
                     TPGKDGHSTDITFTVPGKDPVTVNVKDGENGLNGKTPKVDLLRVQGKNGNPSHTIVTF
                     YTDENNDGKYTPGTDELLGSEMIKDGAKGADGRDGKSLLTVKDGKETKVYQEDPANPG
                     QPLNPEKPLAVIRDGVDGKSPTVTAVRKDEAGHKGVEITVDNHDGSQPTTVFVQDGAK
                     GETGAIGQDGQTPTITTQRGQDGQSTVVTITTPGKDPVTFTVKDGKNGKDGRAPKIKV
                     EDITSPSRIRRATDAAATPTRNGIRVTVYDDVNDNGVYDGGVDKVLNSKDIYNGIDGR
                     DGSAPTITTKDNGDGTHTITVQNPDGSESTTVVKDGKDGKTANITTTENPDGSHTITV
                     TNPDGSTKETVVKNGKDGKTPKVEVTDNNDGTHTVKVTDGDGNVTNAIIKDGKAATAT
                     TTENPDGSHTVTITNPDGTKNEFVVKNGRDGVDGRTPTASVRDNGDGSHTIVITNPEG
                     VTTETTVRDGKSPTAKVVDNGDGTHTITVVNSDGTTTTTTVRDGREPKLEVIDNNDGS
                     HTIKVTGADGKETTTTIFDGKSPKANIVDNGDGTHTLTIVDSDGREYKSIIKDGKDGK
                     DGVSPTVTVENNNDGTHVVTITNPDGSKTEMVIKDGKDGKSPKVSVEDNGDGSHTITI
                     INSDGTVTKTVIKDGKDGRDGRDGRDGKDGKCGCQDKPVTPSNDKPVPPTPNVPTPEV
                     PVKPVPAQPTPNVPTPEVPVQPTPAVPTPEVPVPEQPVVPTPAQPATPVNANPVAPTT
                     GKENRGDKLPETGSQSDYISVLLGSGILLSLYVGRRKED"
     gene            complement(9714..10262)
                     /locus_tag="VVR18_000680"
     CDS             complement(9714..10262)
                     /locus_tag="VVR18_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEU6032250.1"
                     /translation="MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALP
                     LFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDT
                     RGASALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKL
                     VLEETVLNSLEKQAQDLVEAIQ"
     gene            10583..11071
                     /locus_tag="VVR18_000681"
     CDS             10583..11071
                     /locus_tag="VVR18_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5590 domain-containing protein"
                     /protein_id="HEU6032251.1"
                     /translation="MKKRQNKAKNNLLWQYGLGMTILFVVISASFLYMVSLSMKPYQT
                     AKSEGEKLAQQYAGLEQADQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQ
                     LNQGVSQEKAETVSKEKGAGEIDKIIFGRYQDKPIWEVKSGSDFYLVDFETGALVNKE
                     GL"
     gene            11068..12255
                     /locus_tag="VVR18_000682"
     CDS             11068..12255
                     /locus_tag="VVR18_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU6032252.1"
                     /translation="MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTT
                     PKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKY
                     SLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAA
                     RTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTP
                     ISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQ
                     YAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAME
                     MKGYTDVTDFTTVILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGS
                     END"
     gene            12248..12613
                     /locus_tag="VVR18_000683"
     CDS             12248..12613
                     /locus_tag="VVR18_000683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU6032253.1"
                     /translation="MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPN
                     SPHPGGDFWLTQGTQDPVHFAFLAENKEEVQACYEAGLEAGGRDNGAPGYRSEHPIYY
                     AAFMIDLDGNNIEVVCHKE"
     gene            12629..13975
                     /gene="asnS"
                     /locus_tag="VVR18_000684"
     CDS             12629..13975
                     /gene="asnS"
                     /locus_tag="VVR18_000684"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HEU6032254.1"
                     /translation="MMTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTA
                     FFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITD
                     IEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGF
                     MKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRA
                     EKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTE
                     LLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPT
                     FVMNYPVAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDEL
                     GMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP"
     gene            14128..14418
                     /locus_tag="VVR18_000685"
     CDS             14128..14418
                     /locus_tag="VVR18_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HEU6032255.1"
                     /translation="MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWE
                     KRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA"
     gene            14430..14900
                     /gene="ssbA"
                     /locus_tag="VVR18_000686"
     CDS             14430..14900
                     /gene="ssbA"
                     /locus_tag="VVR18_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein SsbA"
                     /protein_id="HEU6032256.1"
                     /translation="MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGER
                     EADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQM
                     LESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF"
     gene            14932..15171
                     /locus_tag="VVR18_000687"
     CDS             14932..15171
                     /locus_tag="VVR18_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HEU6032257.1"
                     /translation="MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKI
                     LPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED"
     gene            15466..16866
                     /locus_tag="VVR18_000688"
     CDS             15466..16866
                     /locus_tag="VVR18_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional Cof-type HAD-IIB family
                     hydrolase/peptidylprolyl isomerase"
                     /protein_id="HEU6032258.1"
                     /translation="MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLRE
                     KGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSDVEEYI
                     SWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFED
                     KGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDG
                     LNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQV
                     DIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMI
                     QGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLP
                     YSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDAIAAVETGAM
                     DKPVEDVVIETIEIED"
     gene            16868..17227
                     /locus_tag="VVR18_000689"
     CDS             16868..17227
                     /locus_tag="VVR18_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HEU6032259.1"
                     /translation="MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENI
                     HETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRR
                     MLPIWTGEALHHLKKKK"
     gene            17281..18030
                     /locus_tag="VVR18_000690"
     CDS             17281..18030
                     /locus_tag="VVR18_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HEU6032260.1"
                     /translation="MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPR
                     FPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVI
                     CDDLKNMPAHIQGSKVDMILCNPPYFKVDPYSNLNESEHYLLARHEITTNLEEICRSA
                     QSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDG
                     STSGFKVLPPLIVHNDDGSYTPEIEEIYYGS"
     gene            18020..18319
                     /locus_tag="VVR18_000691"
     CDS             18020..18319
                     /locus_tag="VVR18_000691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HEU6032261.1"
                     /translation="MDHKAYMYVLECRDGSYYIGYTTDVRRRLAIHNSGKGAKYTRAR
                     LPVKLIYAQGFASKEEAMSAEALLKRKKRPQKEEFLSENQDRNLLSYFEESWGVL"
     gene            18390..19325
                     /locus_tag="VVR18_000692"
     CDS             18390..19325
                     /locus_tag="VVR18_000692"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese-dependent inorganic pyrophosphatase"
                     /protein_id="HEU6032262.1"
                     /translation="MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPN
                     EETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRV
                     ANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTT
                     HPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRV
                     AQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKV
                     EAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA"
     gene            19412..19924
                     /locus_tag="VVR18_000693"
     CDS             19412..19924
                     /locus_tag="VVR18_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000892254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoylalanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="HEU6032263.1"
                     /translation="MLENGDLIFVRDGSDMGQAIQTSTGNYSHVAIYLDGMIYHASGQ
                     AGVVCQEPADFFESNHLYDLYVYPEMDIQSVKERACRHLGAPYNASFYPDAAGFYCSQ
                     YIAEILPIFETIPMKFGDGEQEISDFWREYYIELGLPVPLNQAGTNPSQLAASPLLQC
                     KERNLHDSDF"
     gene            19949..20557
                     /locus_tag="VVR18_000694"
     CDS             19949..20557
                     /locus_tag="VVR18_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1803 domain-containing protein"
                     /protein_id="HEU6032264.1"
                     /translation="MFGELNRYLDQYEDVILREIKAQFPDIAVDKLMEEYIKAGLILR
                     ENKRYYLNFPTLESLDSLELDQEIFVREASPVYQALLEQSFETELRNQINAAILVEKT
                     DFARIKMTLSNYFYKVKQQYPLTEKQQELYDILGDVNPEYVLKYMTAFLLKFLKKDQL
                     MQKCRDIFVDSLVVLGYIVQNEDGKYELAIDFDKERLTFYLA"
     gene            20658..20855
                     /locus_tag="VVR18_000695"
     CDS             20658..20855
                     /locus_tag="VVR18_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEU6032265.1"
                     /translation="MSLENKLEQATGAVKEGFGKVTGDSKTELEGAVEKTVAKAKDVV
                     ENAKGAVEGAVEGLKNVFTKE"
     gene            complement(20898..22343)
                     /locus_tag="VVR18_000696"
     CDS             complement(20898..22343)
                     /locus_tag="VVR18_000696"
                     /EC_number="6.3.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-
                     lysine ligase"
                     /protein_id="HEU6032266.1"
                     /translation="MIKIETVLDILKKDGLFREIIDQGHYHYNYSKVVFDSISYDSRK
                     VTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYEVGIPVIIVNDIKKAMSLIAME
                     FYGNPQEKLKILAFTGTKGKTTAAYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALT
                     TPESIDLFDMMNQAVQNDRTHLIMEVSSQAYLVKRVYGLTFDVGVFLNISQDHIGPIE
                     HPSFEDYFYHKRLLMENSRAVIINSDMDHFSVLKEQVEDQNHDFYGSQFDNQIENSKA
                     FSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATRVPGRMEV
                     LTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLN
                     QHPEIQVFLTADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAV
                     IIAGKGADCYQIIQGKKESYPGDTAVAENYL"
     gene            22449..24071
                     /locus_tag="VVR18_000697"
     CDS             22449..24071
                     /locus_tag="VVR18_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEU6032267.1"
                     /translation="MSHENNHQQAQMLRGTAWLTASNFISRLLGAVYIIPWYIWMGAY
                     AAKANGLFTMGYNIYAWFLLVSTAGIPVAVAKQVSKYNTMREEEHSFALIRSFLGFMT
                     GLGLVFALVLYVFAPWLADLSGVGKDLIPIMQSLAWGVLIFPSMSVIRGFFQGMNNLK
                     PYAMSQIAEQVIRVIWMLLATFIIMKLGSGDYLAAVTQSTFAAFVGMVASFAVLIYFL
                     AQEGSLKRVFETGDKINSKRLLVDTIKEAIPFILTGSAIQLFQILDQLTFINSMSWFT
                     NYSNEDLVVMFSYFSANPNKITMILISVGVSIGSVGLPLLTENYVKGDLKAASRLVQD
                     SLTLLFMFLLPATVGVVMVGEPLYTVFYGKPDSLAMSLFVFAVLQSIILGLYMVLSPM
                     LQAMFRNRKAVLYFIYGSIAKLVLQLPTIALFHSYGPLISTTIALIIPNVLMYRDICK
                     VTGVKRKVILKRTILISLLTLVMFLLIGTIQWLLGFFFQPSGRLWSFFYVALVGAMGG
                     GLYMVMSLRTYLLDKVIGKAQADRLRAKFKLS"
     gene            24274..26232
                     /locus_tag="VVR18_000698"
     CDS             24274..26232
                     /locus_tag="VVR18_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6032268.1"
                     /translation="MKKSKSKYLTLAGLVLGTGVLLSACGNSSTASKTYNYVYSSDPS
                     SLNYLAENRAATSDIVANLVDGLLENDQYGNIIPSLAEDWTVSQDGLTYTYKLRKDAK
                     WFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGV
                     KALDDQTVQYTLVKPELYWNSKTLATILFPVNADFLKSKGDDFGKADPSSILYNGPFL
                     MKALVSKSAIEYKKNPNYWDAKNVFVDDVKLTYYDGSDQESLERNFTAGAYTTARLFP
                     NSSSYEGIKEKYKNNIIYSMQNSTSYFFNFNLDRKSYNYTSKTSDIEKKSTQEAVLNK
                     NFRQAINFAFDRTSYGAQSEGKEGATKILRNLVVPPNFVSIKGKDFGEVVASKMVNYG
                     KEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDKTVEVTDKVGIQGV
                     SSIKQSIESVLGSDNVVIDIQQLTSDEFDSSGYFAQTAAQKDYDLYHGGWGPDYQDPS
                     TYLDIFNTNSGGFLQNLGLEPGEANDKAKAVGLDVYTQMLEEANKEQDPAKRYEKYAD
                     IQAWLIDSSLVLPSVSRGGTPSLRRTVPFAAAYGLTGTKGVESYKYLKVQDKIVTTDE
                     YAKAREKWLKEKEESNKKAQEELAKHVK"
     gene            26404..26949
                     /locus_tag="VVR18_000699"
     CDS             26404..26949
                     /locus_tag="VVR18_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032269.1"
                     /translation="MKLKLLRVDTKVIMGSFLLVLSSLLALLLPLILKGLIDGSSIEN
                     IGSKVFQSFLIFIGQALFSSIGYYLFSQSGEKKIAKIRKKVIEGLIYAEKSFFDKSQS
                     GELTSAIVNDTSVIREFLITTFPNIILSLVMVLGSIVVLFSLDWNLSLLLFITLPCMM
                     FIILPLSNISEKYSRRLQEEI"
     gene            26958..28079
                     /locus_tag="VVR18_000700"
     CDS             26958..28079
                     /locus_tag="VVR18_000700"
                     /inference="COORDINATES: protein motif:HMM:NF012869.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032270.1"
                     /translation="MTEKIQEHELIKTNQAEKSVQDVLDNCIERVQNNSLKSDRVTSF
                     ETSFALLFIFATIVVMLTYGGYRVSAGYISVGTLVSFLIYLFQLLNPISNIANFVTIY
                     SSSKGSSVALENLLAVPKEKFEGGKSVSGQGLNFNHVYFGYDENRPVLKDITCSIFKG
                     QKIAFVGPSGSGKSTIVRLLERFYKPLSGYILMEQSSIYDFNLKEWRSKIAWVSQNNA
                     VLSGSIRDNLCLGLNRLVTDDELMKVLDLVSLGDEIRSMKEGLDTEVGERGRLLSGGR
                     SQRLQIARAYLKDAEILIFDEATANLDADSEYAIISSLYSVLKEKTVVIIAHRLSTVK
                     DVDCIFFLEEGKITGSGTHKELLENHERYARFVQEQMIE"
     gene            28237..29331
                     /locus_tag="VVR18_000701"
     CDS             28237..29331
                     /locus_tag="VVR18_000701"
                     /EC_number="2.5.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HEU6032271.1"
                     /translation="MSKELHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGRST
                     GFDYTRTKNPTRSKAEEVLAAIESADYALATSSGMSAIVLAFSVFPVGSKVLAVRDLY
                     GGSFRWFNQVEQEGRFHFTYANTEEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAK
                     LAHAKGAKVVVDNTFYSPIYQRPIEDGADIVLHSATKYLAGHNDVLAGVVVTNSLELY
                     EKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTANAQEVVAFLKDSPAVKEVLY
                     TGRGGMISFKVADETRIPHILNSLKVFSFAESLGGVESLITYPTTQTHADIPAEVRHS
                     YGLTDDLLRLSIGIEDTRDLIADLRQALEG"
     gene            29339..30505
                     /locus_tag="VVR18_000702"
     CDS             29339..30505
                     /locus_tag="VVR18_000702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU6032272.1"
                     /translation="MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPE
                     IRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAI
                     QTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEE
                     VKLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTI
                     NPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLA
                     TEAAYRYGKDWLEELKQVFEDHINYVMDLFGKETKIKVMKPQGTYLIWLDFSAYDLTD
                     ETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR"
     gene            30598..33696
                     /locus_tag="VVR18_000703"
     CDS             30598..33696
                     /locus_tag="VVR18_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU6032273.1"
                     /translation="MAKLIPGKIRIEGVALYETGKVDIIKEKNNRLYARVAEEELRYS
                     LEDDLVFCACDSFQKRGYCVHLAALEHFLKNDERGQEILWSLEEGHEEKEAVETKVTL
                     GGKFLNRILSPKSECAYELSAVGQVEAGTNHILWTLRIGQINSQKYYVIRDILLFLRI
                     VEQRKSYMIGKIYEESLSWEAFDDASQELLTFLHGLTEEGLVPDLFFQNQGRHLFFPL
                     TFFEQGVNLLMALPHFQFDHQVDSYQTLLFQDMHADANLFAFTVTEYSDYFEMEISES
                     PRVNVFYQGAVLFHKGQVYFLTDQQMRLLKEIKALPVGQQGKKYLQFDSSDRDKLASC
                     LTLFIQMGTVSAPERLQIKTFAPSFYFDREEDNRIRLEIQFDYGNRQVSSRQELEELP
                     FSSDADLEERIFQVCLAAGFESDFQSWRQALKAESVYHFFHDIIPVFEKLGHVDLSDK
                     LEELYSLASPQVQIASKGGLLEIQFDFQDIAQEEIDQAMQALVANQDFYIDSSNQVYF
                     FDEETKKIRQNLQELGQFELKDGTLQARKSLAYSLAHLFEGRDRVSFSQEFQNLAQDL
                     THPEDFPLQATQVKADLRDYQEKGIGWLQMLHHYGFGGILADDMGLGKTLQTIAFLTS
                     QVTKESRVLILAPSGLIYNWADEFQKFAPQLDVAVVHGLKASREEILAESHQIYVTSY
                     ATFRQDSELYQGMAFDFLFLDEAQVMKNAQTKIAQTLRQFVVPSVFALSGTPIENHLG
                     ELWSIFQIVMPGLLPSKKEFMKLPAERVAQFIKPFVMRRKKEEVLTELPDLIEVVYKN
                     ELEDQQKAIYLAQLQQMRDHLAQVSEQEFQRSRVEILSGLMRLRQICDTPALFMEDYQ
                     GASGKLDSLRDLLVQVADGGHRVLIFSQFKGMLEKIEQELPDLGLTSFKITGSTPAKE
                     RQDMTKAFNQGERDAFLISLKAGGVGLNLTGADTVILVDLWWNPAVEAQAIGRAHRMG
                     QEETVEVYRLVTKGTIEEKIQELQEQKKHLVSQVLDGTESRGSLTLAEIREILGISEA
                     ST"
     gene            33744..34361
                     /locus_tag="VVR18_000704"
     CDS             33744..34361
                     /locus_tag="VVR18_000704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HEU6032274.1"
                     /translation="MKQERFPLVSDDEVMLTEMPVMNLYDESDLISNIKGEYRDKNYL
                     EWAPIAEEKPVKPIEKQVGKPKKAPLGVKKEGKSYAEVAREEARADLKKKRSANYLTQ
                     DFSLARRHSQPSLVRQGNQPTTPFQKENPGEFVKYSQKLTQSHYILAEEVHSIPTKNE
                     EVSAPAPKKNNYDFLKKSQIYNKKSKQTEQERRVAQELNLTRMTE"
     gene            34372..35706
                     /locus_tag="VVR18_000705"
     CDS             34372..35706
                     /locus_tag="VVR18_000705"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HEU6032275.1"
                     /translation="MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGL
                     EQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRD
                     FVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
                     MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDA
                     PIYYYGFEAEGNDFVASDLLRSTTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIG
                     LLYTAGFDLNLVREHLKTFSGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKY
                     PSKEIVAVFQPHTFTRTIALLDDFAHALNQADAIYLAQIYGSAREVDHGDVKVEDLAN
                     KINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ"
     gene            35716..36180
                     /locus_tag="VVR18_000706"
     CDS             35716..36180
                     /locus_tag="VVR18_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032276.1"
                     /translation="MEIPIKIIQASKSDLPEIGALQTSSFPAEKQQLSHILEESIRKC
                     ADTFLLARDENQLLGYILSSPQSDNPQCLKVHSLVIESDHQRQGLGTLLLAALKEVAV
                     ELDYKGIRLESPDELLSYFEMNGFVDEEATLLYATSQGYSMIWFNPFYLEEQ"
     gene            36177..36671
                     /locus_tag="VVR18_000707"
     CDS             36177..36671
                     /locus_tag="VVR18_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032277.1"
                     /translation="MKIRQARLEDLDRIVELEFENFSVEEAIPPSVFEAHLREIQTSF
                     LVAEKEGRIMGYIEGPVGLHRHLQDQSFTEEIKDYSHEPGGYISVTCLSIAKEAQGLG
                     LGQKLLTALKEVALEDERDGINLTCHDYLIAYYEKHGFVNEGQSQSTFAGETWYDMVW
                     EMKK"
     gene            36752..38407
                     /gene="mltG"
                     /locus_tag="VVR18_000708"
     CDS             36752..38407
                     /gene="mltG"
                     /locus_tag="VVR18_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HEU6032278.1"
                     /translation="MSEKSREEEKLSFKEQILRDLEKVKGYDEVLKEDEAVVRTPANE
                     PSAEELMADSLSTVEEIMRKAPTVPTHPSQGVPASPADEIQRETPGVPSHPSQDVPSS
                     PAEESGSRPGPGPVRPKKLEREYNETPTRVAVSYTTAEKKAEQAGPETPTPAIETVDI
                     IRDTSRRSRREGAKPVKPKKEKKSHVKAFVISFLVFLALLSAGGYFGYQYVLDSLLPI
                     DANSKKYVTVGIPEGSNVQEIGTTLEKAGLVKHGLIFSFYAKYKNYTDLKAGYYNLQK
                     SMSTEDLLKELQKGGTDEPQEPVLATLTIPEGYTLDQIAQTVGQLQGDFKESLTAEAF
                     LAKVQDETFISQAVAKYPTLLESLPVKDSGARYRLEGYLFPATYSIKESTTIESLIDE
                     MLAAMDKNLSPYYSTIKSKNLTVNELLTIASLVEKEGAKTEDRKLIAGVFYNRLNRDM
                     PLQSNIAILYAQGKLGQNISLAEDVAIDTNIDSPYNVYKNVGLMPGPVDSPSLDAIES
                     SINQTKSDNLYFVADVTEGKVYYANNQEDHDRNVAEHVNSKLN"
     gene            38478..38960
                     /gene="greA"
                     /locus_tag="VVR18_000709"
     CDS             38478..38960
                     /gene="greA"
                     /locus_tag="VVR18_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HEU6032279.1"
                     /translation="MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDL
                     SENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAQDEVAIGKTVTIQEIGEDE
                     EEVYIIVGSAGADAFAGKVSNESPIGQALIGKKTGDTATIETPVGSYDVKILKVEKTA
                     "
BASE COUNT        12269 a         7152 c         8806 g        10866 t
ORIGIN      
        1 aaaaaggttt atttaataaa tatatgttat aataaggtaa attaagccta atggaggaca
       61 aagaaatggg tttttatttg atggttgctt caatgctact cggactgctc gctttgaaga
      121 taggtttttc tcagttcaag gagaaaaaag ataaattctt atctatctta acaagtttag
      181 ctggcatagc ccttgttctc gcggctgtct ggttaggatg gcccaaataa atagaaaaac
      241 ctcggtcaaa ccgaggtttt tcaaatgaat ttcttggttg tggctaaaaa atatgctaca
      301 ctatcaatat gaaaatttta atcccaacag caaaagaaat gaacacagac ttgccaagta
      361 tcgaggcaat tcctttaaaa ccagaaagtc agaccgtgct tgatgccttg gctctctatt
      421 ctgccagtca attggagagt ttctacaagg tatcagctga gaaagcggcg gaagaatttc
      481 aaaatatcca agctttgaaa aggcaaactg ctcaacacta tccagccttg aaactttttg
      541 atgggcttat gtaccgcaac attaagagag ataagctgac cgaggcggaa caagattatc
      601 ttgaaaatca tgtcttcatt acctcggctt tgtacggtgt tgttccagcc ttgtcaccca
      661 tggctcctca ccgtttggat tttttgatga aattaaaagt cgctggtaag actttgaaga
      721 gccattggaa ggcagtctat gatgaagctc tgaagaagga agaagtgatt ttctctctct
      781 tgtcatcaga gtttgagact gtattttcta aggaaatcag agcaaagatg gtgaccttca
      841 aattcatgga ggatagaggc ggtcagctga agattcactc aactatctcc aagaaagcgc
      901 gcggggcctt tctaacagct ttaatagaaa atcaagtaca aactgtgggg gaagcacgtc
      961 gcttgaactt tgctggattt gtttaccgag aagatttgtc acaaccacag ggattggttt
     1021 ttgtaaagga agtatagaaa tcagataaga gaaaagtcag cacgattatg ctgacttttt
     1081 tgataactta taaagtattg gacaaatgaa tctcatttga taaggtgtta agatgattaa
     1141 ccaaattcat gattgacaga tgatttcggc aaataaactt cttggtaatc cctggaatat
     1201 agaaattaga cacgatgata tcgtaatctg tctgatttaa aatctcagga cttgttttta
     1261 attcatccca aatatcgaag gtaaagcggt tattacagta ataggaaagc atatcaacaa
     1321 aggtaaggga tatagcatgg tcaaagttac tgataatcaa aaccttgata ggtggtcgat
     1381 tttctaacaa ctgagtagag aggttttcag catgggttaa gatggtgtac atcaagtgtt
     1441 ccaactgttc aggatggtca tgctgtccaa ttgcctgacg gtattgagcc agttcttgac
     1501 gcgcacttcc cataaagtct gggaagtaaa cttcaaattt tttaatcgtc aatgcttttt
     1561 gttcaaataa gattggggta gaaaagattt cctgtctttc aaagaaagca gtgttgtgta
     1621 aatgccaaat cagctcatcg tggttagtaa aagtaatctt atattgtttt gataggcgtt
     1681 ctaatatttg actaagtaat tggtaagagt atcttgcttg actgttatct tctaaagagt
     1741 tgaagaattc ttgaggatct aggaaaatat cattctgaag aaaagaaata aaaatttgag
     1801 cgattgtatc tggagtcatt tcaagcccaa aatgtttaga gaaataagca agtgtctcct
     1861 ggaaatttgg aatgctcttt aaaagaggat aatattcttt gtaaaagtgg ttggggaggt
     1921 caatgaagtg accattttta accctgtgga tactgatagc tatcatcagt ttgtacattc
     1981 tataaattga aaatcgcatt ggataattcg tgattttata gaagaagtca gcaaactctg
     2041 ttaaatcttc ctcaggaagg tcaggaaaag gccaatctag gaaataatag cgctcagaaa
     2101 agtattgggc aaaaaagtaa cgaatatcga tctcatttcc acgtatctcg gatggagtaa
     2161 aagataattc aatttgaaac tgagatgaaa gaacctttgt aatatttctg cccagtcgat
     2221 agaggttggc actactaaag taaagatttt ctattgttcg ataaataggt agcccctcat
     2281 tgaagaacat atactctagt aattgaaaag attgagaatt agcaagaaaa tattgataaa
     2341 tatcttctac actagtgtta acttctaaat ctatcatgat tccgttaaca gaagattgga
     2401 tgttaataga tggaaaggca atacgtaatt catttaaatc actttttaag attcgttctg
     2461 tgcatcctaa tttttcggct agttcatgta atttcatcca attacgattc tgaattaggg
     2521 tttccattaa gcgtaattgt ctttgaactt ttgtggataa aaggtttctc atacgggtat
     2581 ttcctccata attcattata tctttttttg tctaagtagt ataaaaaaat tagagcaaga
     2641 aaattgtcgt tagtaatcgg aaaaattaga ataatataag tggctttcaa gtgcaaaaac
     2701 agaatatatt aattgttcag aaaatattga ttaatgcctc aaatagttgt acattgtaaa
     2761 ctataaaata ctatctagga gtttaaaatg aaacattcac ataaaaaatc atttgactgg
     2821 tatagcatgc aacaacgtta ttctattcgt aagtattact ttggtgcagt tagtgtcttg
     2881 ctcggtaccg ctttggtatt aggtgcagca gctagtgtcc aaacagtaca agcggaagaa
     2941 aacaaacaag aaactaccaa tagtatttct gttggtaggg gagaagcagc tactaaacca
     3001 gcagaggttt ctgcgtctaa taaagagaaa acctatgcag ctccaactgt agctaatcca
     3061 gtagaaacga ctccagttaa aactggagaa gttactaaac cagcagaaaa agttgaagaa
     3121 gcaaaaaaca aaaaagagga agtaacgcat caagatgcta ttgacaagtc aaaattgtta
     3181 acggctcttt cgcgtgctaa aaagttagaa agcaagttat atacagaagc aagtgctgct
     3241 aacttgcaaa caagtatcca agctggtcaa agcttgcttg ggaaagcaga tgcatctgaa
     3301 gctgaattat cagcagcaga gtcatctatt caatcatcta ttattggtct agaacttcgt
     3361 tctaactcta acaaaggaac tgtatcagaa actcctgtag cgaagaaagc taatatagtt
     3421 gaagcgaagg aagagactaa tccagctgca acaactgatc gttcagctgt tgatagtgct
     3481 gttttgccaa ctagcacagc tgccaaagta gaaacaactt cagctccagc atctattaat
     3541 gaaatcttga aaccaggttt gagcctttct gatgctcgcc aaaatccagc tatccgtaag
     3601 gaagatgttg atagagggta tagtggtttt agagcggcgc ctgctccaac gaaccaacca
     3661 gtaactaatc taggaaataa tactgttttc actgatatta gcagaggttc tcatactttc
     3721 cgtggtaatg gaaattcacg tcgtggaaac ccgattcatt ttgatgtaac aacaactaga
     3781 gttagaaata gagtagattt ctcaatcaga tattcaggac caggtgagtt tgttaataac
     3841 aactttatct tagacaaagg aaatggattc ggagaacctt ctcgtgcaac tgtttcaaca
     3901 ccaaaattaa gagaccaagt taaaaacatt agtaagggtg gaaactttgt ttctcattca
     3961 ggctacagtt tagaagctgc agtagaaaca agcaccaatc aaacaattaa gtttagttta
     4021 cctatagcca accctaatgg tgatctgtct gttcgattaa gacctgttac ttttaatgta
     4081 ggtcaagggg aatcaggatc tgcaactagt aatgatccat atagtaactc taactattac
     4141 ttcagagaaa aaccactcct cttggatgca aatccaaatg gtggtactaa taataagact
     4201 gtttcagaag acattgactt ccaaactgtc tatcttccaa ctagtaagtt accagaaggt
     4261 caaactagat tagttcgaga aggtgaaaaa ggacaacgtc aaattaccta taaagttcat
     4321 cgatttggta acgaaacagt cttaggattg ccaattagta atagagttac taaagaagct
     4381 aagccacgta ttatgcaaat tggtgtggct aaagagctaa tcgatacagt aaaaccacgt
     4441 gttgatcaaa ataaagttgg tgatacaaat aacctcactt tctatcttga taacgatggc
     4501 aacggtgttt atactgaagg tgtagacgaa cttgttcaaa aaattgctat taaagatgga
     4561 gctaaaggtg aaaaaggaga ccaaggtgaa cgcggtctaa ctggagctca aggagctaaa
     4621 ggtgaaaaag gagcccgagg cgaacgcggt ctaactggag ctcaaggagc taaaggtgaa
     4681 aaaggagacc gaggtgaacg cggtctaact ggagctcaag gagctaaagg tgaaaaagga
     4741 gaccgaggtg aacgcggtct aaccggagct caaggagcta aaggtgaaaa aggggaccaa
     4801 ggtgaacgcg gtctaaccgg agcacaaggt gctaaaggtg aaaaaggagc ccaaggtgaa
     4861 cgcggcctaa ctggagctca aggagctaaa ggtgaaaaag gagaccgagg cgaacgcggt
     4921 ctgactggag cccaaggtgc taaaggtgaa aaaggagccc aaggtgaacg cggtctaacc
     4981 ggagcccaag gtgctaaagg tgaaaaaggg gaccaaggtg aacgcggtct cactggagcc
     5041 caaggtgaaa aaggagcccg aggcgaacgt ggtttaactg gagctaaagg tgaaaaagga
     5101 gcccaaggtc aggcaggtcg tgacggtgta actccaaccg taaccgttaa agataataaa
     5161 aatgacggca ctcatactat cactattaac gacggtagag gtaatgttac aagtactgtt
     5221 gtaagagatg gtttcgatgg cgcaagtcca ttagttgcga ctcaacgaaa tgacgcagat
     5281 aagacaacaa ctgttatctt ctattacgat aaaaatggaa acaatgaatt agatgcttct
     5341 gataagaaat taaaagaagt tgtaattgca gatggtgcta aaggtgaaaa aggggacaaa
     5401 ggtgaacaag gtcttcaagg gcgtgatggt gaacaaggac caaaaggaga agatgggaaa
     5461 accccaacag ttaaagtaac tgatggtcaa gatggaacgc atacaattac aattaacgat
     5521 ggtaaaggtg gtataactac tacagtagta agagatggat ttgatggtgc aagccctctt
     5581 gtttctactc atagaaatga agcagataaa acaacaactg ttattttcta ttatgatcta
     5641 aatgataata atcaatttga tgaaggagat acaaaactta aagaagttgt tatcgcagat
     5701 ggaaaacaag gaccaaaagg tgacaaaggt gcagacggtg ccaagggtga aaagggagat
     5761 cagggtgaac gcggtctaac tggatctaaa ggtgaaaaag gagaccaagg tgaacgcggt
     5821 ttaactggag cgcaaggtgc caaaggtgac aaaggtgaac aaggtcttca aggtcgtgat
     5881 ggagctcaag gaccaaaagg cgcagatgga caaagaggac cagcgggacc acaaggacca
     5941 aaaggagaac aaggtaatcc aggaactcca ggtaaagatg gaaaatctct aattgctgtt
     6001 aaaaatggaa ctgaaacaaa agtctatgta gaggatccgg ctagaccagg acaaccactt
     6061 aatccaaacc aaccattagc aactatcact gatggaagaa acggtactaa tggacaatca
     6121 ccaacaatta cagcgacacg aagtgtgcaa aatggcaaaa atggtgtatt agtaacaatt
     6181 acaccagtag gaggtcgtcc acaaacaaca tttgtagagg atggacaaaa gggtgctgat
     6241 gggaaaaccc caacagtaac aataactgag gggcaaaacg gcacacatac attaacggtt
     6301 cataatccag gaagtccaga tgtgacaact acgatccgtg atggagctac aggacaagca
     6361 ggtcgtgatg gtaaagatgt attaaacgga aaagtaaatc cacaaccaaa ccaaggtaaa
     6421 aatggagata aatatattaa taccgaaacc ggtgatgtct atgttaaaaa caatggaaac
     6481 tgggataaag aaggcaacat caaaggccct aaaggtgaca aaggtgcaga tggtgctaaa
     6541 ggcgaaaaag gagaccaagg cgaacgcggc ctaactggag cgcaaggagc taaaggtgcg
     6601 gatggcgcag taggtcgtga tggacgtgac ggtaaagacg tgttgaacgg caaagctaac
     6661 ccagaagcac atcaaggtaa agacggcgat aaatacgtta atacagaaac aggcgacgtc
     6721 ttcgttaaga ataacggcaa ctgggataaa gagggcaaca tcaaaggccc taaaggtgac
     6781 aaaggtgcag atggtgctaa aggcgaaaaa ggagaccgag gcgaacgcgg cctgactgga
     6841 gcgcaaggag ctaaaggtgc ggatggagca gcaggtcgtg acggacgtga tggacgtgac
     6901 ggtaaagacg tgttgaacgg caaagttaac ccagaagcaa atcaaggtaa agacggcgat
     6961 aaatacgtta atacagaaac aggcgacgtc ttcgttaaga ataacggcaa ctgggataaa
     7021 gagggcaaca tcaaaggccc taagggtgac aaaggtgaac gcggagaaga tggtaagact
     7081 ccagaagtaa ctgtaactcc aggtaaagat ggccatagta ctgacattac attcactgtt
     7141 ccaggtaaag atccagttac agtaaatgtt aaggacggag aaaatggtct gaacggtaaa
     7201 actccaaaag ttgatttact tcgtgtccaa ggaaaaaacg gaaatccatc tcatacaatt
     7261 gtgacattct atacagatga aaacaatgac ggcaaatata caccaggaac tgatgaactt
     7321 ctaggttcag aaatgattaa agatggtgct aaaggcgcgg acggacgaga tggtaaatca
     7381 ttgcttactg tcaaggatgg taaagaaact aaagtttacc aagaagatcc agctaaccca
     7441 ggacaaccat taaatccaga aaaaccactt gcggtaatta gagatggagt agatggaaaa
     7501 tcacctacag ttacagctgt tcgtaaagat gaagcagggc ataaaggtgt agaaatcact
     7561 gttgataacc atgatggttc acaaccaact acagtctttg ttcaagatgg tgctaaggga
     7621 gaaactggtg caatcggtca ggatggacaa actcctacaa tcactactca acgtggacaa
     7681 gatggccaaa gcactgttgt aactatcaca acaccaggta aagatccagt aaccttcact
     7741 gtaaaagatg gtaagaatgg taaagatggc cgtgcaccga aaatcaaagt agaagatatt
     7801 acttcacctt caagaattag acgcgctaca gatgctgctg caactccaac gcgtaacggt
     7861 atccgtgtta cagtttatga tgatgttaat gacaatgggg tatacgacgg aggtgtcgat
     7921 aaagtattaa atagtaaaga tatttataac ggtatagatg gacgtgatgg ttcagctcca
     7981 actattacta caaaagataa tggagatgga acacacacta tcacagttca aaatcctgat
     8041 ggttctgaat caacaactgt tgttaaagat ggtaaagacg gtaaaactgc gaatatcact
     8101 acaacagaaa acccagatgg aagccacaca attacggtga caaatccaga tggttcaact
     8161 aaagaaactg ttgttaaaaa cggtaaagac ggtaagactc ctaaagttga agtaacggat
     8221 aacaacgatg gaactcacac agttaaagtg acggatggag acggtaatgt aacgaacgct
     8281 atcatcaaag atggtaaagc tgcaacagca acaactactg aaaatccaga tggaagccac
     8341 acagtaacaa tcactaaccc agacggaact aagaatgagt ttgttgttaa gaatggacgt
     8401 gacggtgttg acggacgtac tccaaccgca tctgttcgtg ataatggaga cggaagtcat
     8461 acaatcgtta ttacaaatcc agaaggtgtg acaactgaaa ccacagttcg tgacggtaaa
     8521 tcaccaactg ctaaggttgt ggataacgga gatggaacac acactatcac agttgtgaac
     8581 tcagacggaa caactacaac aactacagtt cgtgatggta gagaaccaaa acttgaagtt
     8641 attgataaca acgatggttc acacactatt aaagtgacag gtgctgatgg taaagaaacg
     8701 acaactacaa tctttgatgg taaatcacca aaagcgaaca tcgttgataa cggagatgga
     8761 actcatacat taacaatcgt agattctgat ggtcgtgaat acaaatctat tattaaagat
     8821 ggtaaagacg gcaaagatgg cgtttcacca actgtaactg ttgaaaataa taacgatgga
     8881 actcacgttg ttacaatcac taatccagat ggaagtaaga cagaaatggt gattaaagac
     8941 ggtaaagatg gtaaatcacc aaaagtttct gttgaagata atggtgatgg tagtcataca
     9001 atcacaatca tcaattctga tggaactgtg acaaaaacag ttattaaaga tggcaaagat
     9061 ggtagagatg gacgtgatgg tagagacggc aaagatggaa aatgtggatg ccaagacaaa
     9121 ccagtaacac catcaaatga caaaccagtt cctccaacac caaatgtgcc gacaccagaa
     9181 gtaccggtta aacctgtgcc agcgcaacca acaccaaatg taccgacacc agaagtgcca
     9241 gtacaaccaa ctccagctgt tccaacacca gaagtaccgg ttccagaaca accagtagta
     9301 ccaacaccgg ctcaaccagc aactccagta aatgctaatc cagtagcacc aactacaggt
     9361 aaagaaaacc gtggggacaa attacctgaa actggaagcc aatctgatta tatctctgtt
     9421 cttttaggta gcggtattct attgagccta tatgtaggac gaagaaaaga agattaatca
     9481 gccaaaagca gtcactaatt tctcgaaaga agatgataag tgatagatct cgaatgaaag
     9541 aatattctta gaatgatttt cctatgatgg aaaagactgc taaaaacctt gagtggtaac
     9601 gctcaaggtt tttttggatg gctgatgttt gtctgaaaat cttgattgag aaataaaaag
     9661 ccaccctatt aggtggctat aattgattta gactttctaa aattttctat tttttactga
     9721 atcgcttcga ccaagtcttg agcttgtttt tcaagtgagt ttaggactgt ttcttcaaga
     9781 accaattttc cgtctgccca ggcagagtca ttaacacgtg cagcagtgaa atcaccaacg
     9841 ccttgtgtac ggataaatgg caagaggtct ttgtagatag cgaaaagttg atcgtgccct
     9901 gcattggcta cagatgatac tgtgacaaac ttgtcttgaa gggcagaagc gccacgtgta
     9961 tcagacaagt caagggcacg agatagccag tcaagcaagt tttttactgt accagggata
    10021 gagaagttgt agactggaga gaaaatccag atagcatccg caacgagaac tgcttcacga
    10081 gcagcagcta cagctggatg tgttggaact tccaaatctt ggctgaagag aggaagggct
    10141 gaataatcaa ggtagctaac ttccgcttta ccagcaagtg ctttctcagc ttcgagcgcc
    10201 atttggtggt tgaaagaacc ttgacgtagt gatccgacga taaataatac ttttttagac
    10261 atgatgtgtc tcctttttct taaaatttcg agaactctct cgttgttata aaatatatta
    10321 caacaaaaca aaagaacttg caagaaattt gctcagagtt tatttgaaaa ttgtaaaatt
    10381 tcggaaactc taatcatttg tgactgaaaa agtaagaact gtttcacttt caaaatcggt
    10441 tttgtttgaa gggagaaata gaattggttg ctcaaagcac agctttgagg ttgcagataa
    10501 agctgacgtg gtttgaagag attttcgaag agtattctta tattcacttg taataaagct
    10561 taatagatgg taaaatagac gagtgaaaaa aagacaaaac aaagcaaaaa ataatctact
    10621 gtggcagtat ggtctaggga tgacgatttt gtttgtggtt atcagtgctt cctttctgta
    10681 tatggtttct cttagcatga aaccctatca aacagctaaa agtgaaggag aaaaattagc
    10741 tcagcagtat gcaggattag agcaggccga tcaggttgat ttatacaatg gcttggaatc
    10801 ttattacagc gttcttggtc gtaataaaca gcaagaagca cttgctgttc tgattggaaa
    10861 agatgatcat aagatttacg tttatcagct aaatcagggt gtttcacaag aaaaagcaga
    10921 aacggtttct aaggaaaagg gagctggcga aattgacaag attatctttg gtcgttatca
    10981 agataagcca atctgggaag tcaagtcagg atctgatttt tatctagtag attttgaaac
    11041 aggagcattg gtcaacaagg agggcctatg aaattatcca accgtgtttt agaaatggaa
    11101 gaaagtgtga ctttggctgc tggagcccgt gccaaagcac tgaaggctga gggtagagat
    11161 attttgtctc taaccttggg tgagccagat ttcactactc ccaaaaatat ccaagatgcc
    11221 gccattgcat cgattcgaga tgggcgtgct tctttttata cagtaacctc aggtctgcca
    11281 gagcttaagg cggcggtcaa tagctacttt gagcgctttt acggctattc tgtagcgtca
    11341 aatcaagtga cagtcgctgc gggagccaaa tattctctct ataccttctt tatggctgtg
    11401 gtcaatccag gtgatgaagt catcatccca accccatact gggttagcta tggagatcag
    11461 gtcaagatgg cagaaggcgt tcccgtcttt gtttctgcta aggaagacaa tcactttaag
    11521 gtgaccgtag agcagttaga agcagctcgc actgacaaga ccaaggtttt ggtgctgaat
    11581 tcgccatcta atcccacagg tatgatttac acccgtgagg aactcttggc aattggaaac
    11641 tgggctgtag aaaatgatat tctcatccta gcagatgata tctatggccg cttggtttat
    11701 aatggtcatg agttcacacc gatttctagc ctatcggaag cgattcgcaa gcaaacagtg
    11761 gtcatcaatg gtgtgtctaa aacctatgcc atgactggtt ggcggattgg ttatgccgtt
    11821 ggagaagcag acattatcgc tgccatgtcc aagattgcag gtcaaacaac ttcgaatccg
    11881 tcagcagtag cccaatatgc agcagttgag gctctatcag gtgagcaaga tactgtagaa
    11941 agcatgcgtc aggcctttga agaacgtctt aataccatct atcccctcct tgcagaagtg
    12001 ccaggatttg aagtggtcaa accgcaaggg gccttctatc tcttcccaaa tgtcaaaaag
    12061 gccatggaga tgaaaggcta cacggatgtg acagacttta caactgttat cttagaagaa
    12121 gccgaagtgg ccttggtaac aggagctgga tttggagcac cagaaaatgt ccgcctcagc
    12181 tatgcgacag acctagacac gcttaaagaa gcagtcgaac gcttgaaagc atttatgggt
    12241 agtgagaatg attgatcatt ttgagattaa ggtaaaggat ttacaaattt cagaaggatt
    12301 ttataggagt tttctcgctc ctttggacta taaattggct tttaagacta gttctctaat
    12361 tagttttcta tccccgaaca gccctcatcc tggtggtgat ttttggctga ctcagggaac
    12421 acaagatcct gttcattttg cttttttagc agaaaataag gaagaagttc aggcttgtta
    12481 tgaggctggc ttagaggcag gtgggcgaga caatggggct cctggttatc gaagtgagca
    12541 tccgatttac tatgctgctt ttatgattga cctggatggg aacaatatag aggtggtttg
    12601 ccataaagaa taaaaaagaa aaggaaaaat aatgacaaaa cgtgtaacga ttattgacgt
    12661 aaaagactat gttggtcagg aagtgacgat tggcgcttgg gttgccaaca aatcaggaaa
    12721 agggaaaatc gctttcttac aattgcgtga tggaacagcc ttctttcaag gtgtggcttt
    12781 taaaccaaac tttgtcgaaa aatttggtga agaagtggga cttgagaagt ttgatgttat
    12841 caaacgcttg agccaagaaa cgtctgttta tgtgacaggt attgtcaaag aggacgaacg
    12901 ttctaaattt ggctatgagt tggacatcac agacatcgaa gtgatcggtg aatctcaaga
    12961 ctacccaatc acaccaaaag aacacggaac agactttttg atggataacc gtcacttgtg
    13021 gctacgctct cgtaagcaag tagctgtgtt gcaaatccgt aacgctatta tctatgcaac
    13081 ttatgagttc tttgacaaga acggttttat gaagtttgac agcccaattc tttcaggaaa
    13141 tgcggcagaa gattctacag aactctttga aactgactac ttcggaacgc cagcctactt
    13201 gagccaatca ggtcagcttt acctagaagc aggggctatg gctcttggtc gtgtctttga
    13261 ctttggtcca gttttccgtg ctgaaaaatc aaaaacacgc cgtcacttga ctgagttctg
    13321 gatgatggat gctgagtact catacttgac acatgatgag tcgcttgact tgcaagaagc
    13381 ttatgtgaaa gctcttctac aaggtgttct tgaccgcgcg cctcaagcct tggaaacctt
    13441 ggaacgtgat acagaactct tgaaacgcta cattgcagag ccattcaaac gtatcactta
    13501 cgatcaagcc attgacctct tgcaagagca tgaaaatgat gaagatgctg actacgagca
    13561 tcttgagcat ggtgatgact ttgggtcacc acacgaaact tggatttcaa accactttgg
    13621 tgtgccaaca tttgtcatga actatccagt agccatcaag gccttctaca tgaaaccagt
    13681 tcctggaaat ccagagcgcg tgctttgtgc agacttgctt gctccagaag gctatggaga
    13741 aattatcggt gggtctatgc gtgaggaaga ttacgatgcc cttgtcgcta agatggatga
    13801 acttggcatg gatcgtacag aatatgaatt ctaccttgac cttcgtaaat acggtacagt
    13861 tccacacgga ggatttggta tcggtatcga acgtatggta accttcgcag caggaacaaa
    13921 acatatccgt gaagctattc cattcccacg tatgttgcac cgtatcaaac cataagaaca
    13981 ggaaaacgcc catgtggcgt tttttcgaat tctagtgttt ttacttgcgt aaaaaaattt
    14041 tttctagtat aatagtttac tgtgagcgaa cctcacttac cccttgcaaa gtcttggggt
    14101 cattagacca aaaggaggaa catatcaatg gctaaatacg aaattcttta tatcattcgt
    14161 ccaaacattg aagaagaagc taaaaacgct ttggtagcac gttttgactc tattttgact
    14221 gacaacggtg caactgttgt tgaatcaaaa acttgggaaa aacgtcgtct tgcatacgaa
    14281 attcaagatt tccgtgaagg actttaccac atcgttaacg ttgaagcaaa tgacgatgca
    14341 gctcttaaag agtttgaccg tctttcaaaa atcaacgctg acattcttcg tcacatgatc
    14401 gtcaaaattg acgcgtaaga aggtaaacta tgattaacaa tgttgtactt gtagggcgta
    14461 tgacacgtga cgctgagttg cgttataccc catcaaatgt agcagttgcg acttttactc
    14521 ttgcagtaaa ccgtacattt aagagtcaaa atggtgaacg tgaggctgat tttatcaatg
    14581 tcgttatgtg gcgccaacag gctgaaaatc ttgctaactg ggctaaaaaa ggctcactta
    14641 tcggggtgac aggtcgtatc cagactcgta gttacgataa ccagcaagga caacgtgtct
    14701 acgtgacaga ggtcgtggct gagaatttcc aaatgttgga aagccgtagt gtgcgtgagg
    14761 gtcacacagg tggagcttac tctgcaccaa ctgcaaacta ttcagcacct acaaattcag
    14821 taccagactt ttcacgtaat gaaaatccat ttggagcaac aaacccattg gatatttcag
    14881 atgatgattt accattctaa tggacaacta aacttataaa ggagaaaaaa catggctcaa
    14941 caacgtcgtg gcggattcaa acgccgtaaa aaagttgatt acatcgcagc aaataaaatt
    15001 gaatatgttg attacaaaga tactgaactt cttagccgtt tcgtttcaga acgtgggaaa
    15061 atccttcctc gtcgtgtaac aggaacttca gctaaaaacc aacgtaaagt aacaacagct
    15121 atcaaacgtg ctcgcgtaat ggctttgatg cctttcgtaa acgaagatta aagaaaagac
    15181 ccggttgggt ctctttttca tgagcttgaa aacaagaaag cgaattaaga ccccaacggg
    15241 tcttttttca caagctttga aatgagagag cgagttaggc tcagtggctc cctttttacg
    15301 agtttgaaaa caagagaaca cattaaaagc acgatggagc tttttcataa atatgtctct
    15361 tttctcatcc aagaaattaa aataaaaatg ataaactttt tgaaaatagg ggatttgcct
    15421 actttatgat ataatggaaa gagttagatt gaaagaggta gtgagatgga cgcgaaatta
    15481 agatacaagg caaagaagat caagattgtc ttttttgata ttgatgatac attgcggaat
    15541 tcaaagacag ggtttattcc aactacaatt cccactgttt ttaaacagtt gcgtgaaaaa
    15601 ggaattttaa caggaatcgc ctctggacgt ggcatttttg gtgttgttcc agagattcgt
    15661 gatctcaagc ctgacttttt tgtaactttg aatggggctt atatcgaaga taaaaaaggt
    15721 caggtcattt atcagcatca gattgaaaag tcagatgttg aggagtatat ctcttgggct
    15781 aagcaagaag gaattgagta tggcttggtt gggagtcatg atgccaagtt gtcgactcgc
    15841 accgatatga tgagtgaagc tatcaatcca atttatcccg acttagatgt agatcccgat
    15901 ttccatgaaa aagaagatat ctatcagatg tggacttttg aagataaggg agatgacttg
    15961 cacttgcctg atagtctctc agacaaactt cgcatggttc gttggcatca acattcgtct
    16021 gatattgtgc cgatttcagg ctccaaagcg acgggggtgg aaaaggttgt ggaacacctt
    16081 ggcttgaaac cagagaaggt catggttttt ggagatggtc tcaacgactt ggaactcttt
    16141 gattatgctg gaatcagcgt tgctatggga atttctcatg ataaaatcaa agaaaaagca
    16201 gattatatta caaaaacatt agaagaagat ggcatttttg atgccttaga agtatttggt
    16261 atggtagaaa aagaattgca ttttccacaa gtagacattg aaacagtaga aggtcctctt
    16321 gcgactatta agaccaatca cggagactta cgtatcaagc ttttccctga acatgctcct
    16381 aaaacagtgg ctaactttgt atctctttca aaagatggct actatgatgg tgtcattttc
    16441 caccgtatta tcaaggactt tatgatccaa ggtggagacc caactggaac tggtatgggt
    16501 ggcgagtcaa tctacggcga atcttttgag gatgaattct cagaagagct ttacaatatc
    16561 cgtggtgctc tttccatggc aaatgctggt ccaaatacca acggcagcca gttctttatc
    16621 gtgcaaaacc aacacctacc ttattctaag aaagaaatta ctcgtggtgg ttggccagaa
    16681 ccgattgcag aaatctatgc caatcaaggt gggacacctc acctagaccg ccgtcacacg
    16741 gtttttggtc agttagctga tgaagcatct tacgctgtct tggatgccat tgctgctgtt
    16801 gagacaggag ctatggacaa gccagttgaa gatgttgtaa ttgaaactat tgaaatcgag
    16861 gactaagatg aaaatcggtg ataagctaaa ggggcgtatt acagggattc agccctacgg
    16921 tgcctttgtt gagttagaga cgggtgatac ggggctgatt cacatttcag aaattcggac
    16981 aggatttatt gaaaatattc atgaaacctt gaaagtcgat gaagaggttc aagttcaggt
    17041 agtggattta gatgaattta cggggaaagc cagtctttct atccgcactt tggaggaaga
    17101 aaagtaccag tttcctagac ggagacgctt ttcaagcgac cgctttaact acggttttgc
    17161 tccctttcga cgaatgctac caatctggac tggagaagcc ctgcaccatt taaaaaagaa
    17221 gaagtagttt agagttttat attttttgta atgttaatat aaatttgcta taataggacc
    17281 atggaagaag aacaattatt aaaatcagga gagcgcatta accagctctt ttcgacagat
    17341 atcaaaatca ttcaaaatag agaggttttt agctattcgg tggatagtgt tctcttatca
    17401 cgatttccac gttttcctaa gaaggggttg attgtggatt tctgtgctgg gaatggagca
    17461 gtggggcttt ttgctagcac tcgtactcaa gcacagatat tgtctgttga gattcaggag
    17521 cgtttggcgg atatggctga acgctctgtc cgtttgaatg gattagagga gcaaatgcag
    17581 gtcatctgcg atgatttgaa aaatatgcct gctcacattc aggggagtaa ggtggatatg
    17641 attttgtgta atccacccta tttcaaggtg gatccttatt ctaatctgaa cgagagtgaa
    17701 cattatctct tggctcgaca cgaaatcacg actaatttgg aagaaatctg tcgtagtgcc
    17761 cagagtattc tcaagtctaa tgggcgtttg gccatggttc atcgtcctga tcgacttctg
    17821 gatattttgg atacgttaaa acgacataat ctagccccta agcgcctgca gtttgtttat
    17881 ccaaaaagag aaaaggaagc caatatgctt ttgattgagg cgatcaagga tggctcaaca
    17941 agtggcttta aggtcttacc tcctttgatt gtccacaatg atgatggctc ttatacgccc
    18001 gaaatcgaag agatttatta tggatcataa ggcttatatg tacgttctgg agtgtcgtga
    18061 tggatcctac tatataggct atacgactga tgtgagaaga cgcctcgcta tccacaatag
    18121 tgggaaggga gccaaatata cacgagcacg cttgccagtc aaacttatct atgctcaagg
    18181 ttttgccagt aaggaagaag ccatgtcggc tgaagctctt ctcaagcgta agaagaggcc
    18241 acagaaggaa gaatttttat ctgaaaatca agatagaaat ttactcagtt attttgaaga
    18301 atcgtgggga gtcctttgac tcctcttacc tttgtcaaaa agcgaaaaaa atgctacaat
    18361 aaagaaaata aacaaaatga ggtattatca tgtccaagat tctagtattt ggtcaccaaa
    18421 atccagactc agatgccatc gggtcatctg tagcttttgc ctaccttgca aaagaagctt
    18481 acggtttgga tacggaagct gttgcccttg gaactccaaa tgaagaaaca gcctttgtct
    18541 tgaactattt tggtgtggaa gcaccacgtg ttatcacttc tgccaaagca gagggggcag
    18601 agcaagttat cttgactgac cacaatgaat tccaacaatc tgtatcagat atcgctgaag
    18661 tagaagttta tggtgttgta gaccaccacc gtgtggctaa ctttgaaact gcaagcccac
    18721 tttacatgcg tttggagcca gttggatcag cgtcttcaat cgtttaccgt atgttcaaag
    18781 aacatggtgt agctgtgcct aaagagattg caggtttgat gctttcaggt ttgatttcag
    18841 atacccttct tttgaaatca ccaacaacac acccaacaga taaaatcatt gctcctgaat
    18901 tggctgaatt ggctggtgtg aacttggaag aatatggttt agcaatgttg aaagctggta
    18961 ccaacttggc tagcaaatct gctgaagaat tgattgacat cgatgctaag acttttgaac
    19021 tcaacggaaa taatgtccgt gttgcccaag tgaacacagt tgacatcgct gaagttttgg
    19081 aacgccaagc agaaattgaa gctgcaatgc aagctgccaa cgaatcaaac ggctactctg
    19141 actttgtctt gatgattaca gatatcgtca actcaaactc agaaatcttg gctcttggtg
    19201 ccaatatgga caaggtcgaa gcggctttca acttcaaact tgaaaacaat catgccttcc
    19261 ttgctggtgc cgtttcacgt aagaaacaag tggtacctca attaactgaa agctttaatg
    19321 cgtaagattt tgggtgtcag ctcaaaatcg gaaagtctag tttgccttat atcgaaagga
    19381 gtttcggctc ctttttttct aggagtgaag tatgttagaa aatggcgatt tgatttttgt
    19441 gagagatggg tcagacatgg gacaggccat ccagacttcc acaggtaact atagccatgt
    19501 tgccatttat ttggatggga tgatttatca tgctagtgga caggctggtg ttgtctgtca
    19561 agaaccggca gacttctttg agtccaatca tttgtacgac ctctatgttt atccagaaat
    19621 ggatatccag tcggtgaagg aaagagcttg cagacatctt ggagcaccct acaatgcttc
    19681 tttctatcca gatgcagctg gtttctactg ctcccagtat atagcagaaa tcctacctat
    19741 ttttgaaact attcctatga aatttggaga tggagaacag gagattagtg atttttggag
    19801 ggagtattac atagaactag gtctgcctgt tcctctgaac caagctggga ccaatcctag
    19861 tcagttggca gcatcgcctc tgttacaatg taaagaaagg aatcttcatg attcagattt
    19921 ttaatccatc tcgtttgacg agacagccat ttttggagaa ttgaaccgct atctggacca
    19981 gtatgaggat gtgattctac gggaaattaa ggctcaattt ccagatattg cagttgataa
    20041 acttatggaa gagtatataa aggcaggctt gattctacgt gaaaataagc gctattacct
    20101 caattttcct acgcttgaat cacttgatag tcttgaactg gatcaagaga tttttgtcag
    20161 agaagctagt ccggtctatc aagccttgtt ggagcagagt tttgagacgg aattgcgcaa
    20221 tcaaatcaat gcagctattt tagttgaaaa gacggacttt gcgcgcatta aaatgaccct
    20281 gtccaattat ttttacaagg tcaaacagca gtatcctttg acagaaaaac agcaggagct
    20341 ctatgacatt ttaggagatg ttaatcctga gtatgtcctc aagtatatga cggctttttt
    20401 gttgaaattt ctcaaaaaag accagcttat gcagaaatgc cgtgatatct ttgtggacag
    20461 tttggttgtc ttaggctata ttgtgcaaaa tgaagatgga aagtatgagt tggctatcga
    20521 ttttgataag gagagattaa ctttctactt agcgtgattt cttgtttctg agcacattgt
    20581 ttgactttcc ttagtattcg gtataaacta tatgtaaccg gtaacacata tcggaataaa
    20641 ctaaaggata caatcatatg tcacttgaaa acaaattgga acaagcaaca ggcgctgtca
    20701 aagaaggttt tggtaaagtt actggagaca gcaagacaga acttgaagga gctgttgaaa
    20761 aaacagttgc taaggcaaaa gacgttgtag aaaacgcaaa aggtgctgta gaaggtgccg
    20821 ttgaaggttt gaaaaacgtt tttactaaag aataggaaaa aatcaagggt ttcattttcc
    20881 cttgattttt tctattctta taaataattt tctgcgacgg ctgtatctcc tgggtaggat
    20941 tctttcttgc cctggatgat ttggtaacaa tcggctccct tacccgcaat aataactgca
    21001 tctaattcgt gatttgtgat agccattgcc gccttgatgg cttcttggcg atccgcaatc
    21061 ttttcaacag gatgattgat gtagctacta atttcatctg caatggccat tgggtcttca
    21121 tagttagggt catcagcagt cagaaagact tgaatctcag ggtgttgatt gaggaggagg
    21181 ccaaagtcct tacgacgact ttctcccttg tttcctgttg atcccagaac cagagcaatc
    21241 tttccggttt gatgagtttc aaccacattg atgagttttt tcagactatc cccattgtgg
    21301 gcatagtcga tgaagacctt ggctccattt ttctgagtga ggacttccat acgaccagga
    21361 acgcgggttg cagcgatgcc ttttttgatg tcctcaagac ttgctccgag acggagacaa
    21421 gcaagtccag cagcaactgc attttcttgg ttgaagttgc caatgagttg gatatcataa
    21481 tctccagcga gtttacccgt agctgaaaag ctaaaggctt tggaattctc gatttggtta
    21541 tcaaattggc taccatagaa atcatggttt tgatcttcaa cctgttcttt caagactgag
    21601 aagtggtcca tgtcactgtt aatgatgact gctcggctat tttccatcaa gagacgcttg
    21661 tggtagaaat agtcttcaaa gctagggtgt tcaatcgggc cgatatggtc ttggctgata
    21721 tttaggaaaa ctcccacatc aaaggttaga ccatagacac gtttgaccag ataggcttga
    21781 ctggagactt ccatgatgag gtgggtacgg tcattttgca cagcctgatt catcatgtca
    21841 aagaggtcaa tactctcagg ggttgtcaac gctgacttaa agaaagtctc gccatcaaga
    21901 gttgtgttca tggtcgacaa catagcaggt cgatgccctt gagataagat gttataggcg
    21961 aaataggctg ccgttgtctt acccttagtt cctgtgaagg cgagaatttt gagtttctct
    22021 tgtggattac catagaactc catggcaatc aaactcatgg ctttctttat atcgttcaca
    22081 atgatgacag ggataccgac ttcgtagtcc ttttcagcta cataccaagc taaaccttgt
    22141 gttatagcag aaagaaggta ttctttttta aaggcagcgc cttttgcaaa aaaaagagtg
    22201 tcttctgtta cttttcggct gtcgtagctg atgctatcaa aaacaacttt gctgtagttg
    22261 tagtggtaat gaccttggtc aataatttcg cgaaaaaggc catctttctt taaaatatct
    22321 aatacggttt caatcttaat catactttct attgtaaacc gaaagtcgca aatttacaag
    22381 taacaaggaa aagtttataa tggaagataa ggagtttttc ctagttatca aaattgaatg
    22441 aggaatctat gtcgcacgaa aacaatcacc agcaggccca gatgttacgg gggactgctt
    22501 ggctaacggc tagtaacttt atcagtcgcc tactcggggc tgtttacatt atcccttggt
    22561 acatctggat gggggcttat gcagctaagg caaatggtct ctttaccatg ggttacaata
    22621 tctatgcttg gttcttgttg gtttcaacag cggggattcc agttgcggtg gccaagcaag
    22681 tttccaagta taataccatg cgagaagaag agcatagctt tgccctgatt cggagcttct
    22741 taggctttat gacaggacta ggcctggttt ttgctttagt cttgtatgtc tttgctcctt
    22801 ggctagcaga cttgtctggc gtgggcaaag acttgatccc aatcatgcaa agcttggctt
    22861 ggggagtctt gattttcccg tctatgagtg ttatccgagg atttttccaa gggatgaata
    22921 acctcaaacc ctatgccatg agccaaattg ctgagcaggt cattcgtgtt atctggatgc
    22981 tcctagcaac ctttatcatt atgaagctcg gttcaggaga ttatctagca gccgttaccc
    23041 aatcaacctt tgctgccttt gtcggtatgg tagccagttt tgcagtcttg atttatttcc
    23101 ttgcccaaga aggttcactc aaaagagtct ttgaaacagg agataagatt aacagtaagc
    23161 gtctcttggt tgataccatt aaggaagcca ttccttttat cctgacaggg tctgccatcc
    23221 agctcttcca gattttggat cagctgacct ttatcaatag tatgagctgg tttaccaact
    23281 acagcaatga ggacttggtt gtcatgtttt cttatttctc agccaatcct aataaaatca
    23341 cgatgatttt gatttctgta ggggtttcga ttgggagtgt tggtttgcca cttttgacgg
    23401 aaaactatgt caagggggac ttgaaagcag cttctcgtct cgttcaggac agtctcaccc
    23461 tactctttat gttcttgcta ccagcaacgg ttggagtggt tatggtagga gagcctcttt
    23521 atacggtctt ctatggtaag ccagatagtt tggctatgag cttatttgtc tttgcagttt
    23581 tgcagtctat tattttaggc ttgtacatgg tcttgtctcc aatgcttcag gccatgttcc
    23641 gcaaccgcaa ggccgttctc tattttatct atggttctat tgccaagcta gtcttgcaac
    23701 tacctaccat cgccctcttc cacagttatg gtcctttgat ttcaacaacc attgctctca
    23761 tcattcctaa cgtcttgatg tatcgggata tttgtaaagt aactggtgtc aagcgcaagg
    23821 tgattttgaa gcgaaccatt ttaatcagtt tgctgaccct agtcatgttt ctgttaatag
    23881 gaaccatcca gtggctgtta ggatttttct tccaaccaag tggacgtttg tggagcttct
    23941 tttatgtagc tcttgtcggt gccatggggg gtggacttta tatggttatg agtctgcgta
    24001 cctatttgtt agataaggta ataggaaaag cccaagcaga tcgcctgcga gcaaaattta
    24061 agctttcgta aggtagcatt tataaataaa aggaataagt tgaacaatct tttaggagaa
    24121 cttgaaactt attccttttt tagcgtcaaa atagctaaaa ttatctttca aaaatagcaa
    24181 atgaggtttt tttcgatttt ttggaaaaat aattgactaa acaaaccaaa cgttgtataa
    24241 taaaacaaat atttaaagca ggaggttctg gaaatgaaaa agtctaagag caaatatcta
    24301 accttggcag gtcttgtcct gggtacagga gttttattga gcgcgtgtgg aaattctagc
    24361 actgcatcaa aaacctataa ctatgtttat tcaagtgatc catctagttt gaactatcta
    24421 gcagaaaacc gcgcagcaac atccgatatt gttgcaaatt tggtagacgg gttattagaa
    24481 aatgaccaat atgggaatat tattccatca ttagcagagg attggactgt ttctcaggac
    24541 ggtttgacct atacctacaa acttcgtaag gatgccaagt ggtttacttc tgagggagaa
    24601 gaatatgcgc ctgtaactgc ccaggatttt gtgacaggtt tgcaatatgc agctgataaa
    24661 aaatcagaag ctttgtatct agtgcaggac tctgttgctg gtttggatga ctatatcact
    24721 ggtaaaacaa gcgacttttc aactgtcggt gtcaaggcac ttgatgacca aacggttcaa
    24781 tatactttgg ttaaaccaga actttactgg aattcaaaaa cacttgcaac gatacttttt
    24841 cctgttaatg cagatttcct gaaatcaaaa ggggatgatt ttgggaaggc ggatccatct
    24901 agtattttgt acaatggacc tttcttgatg aaagcacttg tctcaaaatc tgctattgaa
    24961 tataagaaaa accctaatta ctgggatgct aagaatgtct ttgtagacga tgtgaaattg
    25021 acctactatg atggtagcga ccaagaatca ctggaacgta attttacagc tggtgcttat
    25081 actacggctc gtctttttcc taacagctcc agctatgaag ggattaaaga aaaatacaaa
    25141 aacaatatca tctatagtat gcaaaattca acttcatatt tctttaattt taacctagat
    25201 aggaagtctt acaattatac ttctaaaaca agtgacattg aaaagaaatc gactcaggaa
    25261 gcagttctca ataaaaactt ccgtcaggct atcaattttg cttttgacag aacatcttat
    25321 ggggctcagt ctgaagggaa agaaggtgca acaaagattt tgcgtaacct agtggttcct
    25381 ccaaactttg tcagtatcaa gggaaaagac tttggtgaag ttgtagcctc taagatggtc
    25441 aactatggta aggaatggca aggtatcaac tttgcggatg gtcaagaccc ttactacaat
    25501 cctgagaaag ccaaggctaa gtttgcggaa gctaagaaag aactcgaagc aaagggtgtt
    25561 caattcccaa tccacttgga taagactgtg gaagtaacag ataaagtagg catacaagga
    25621 gttagttcta tcaaacaatc aattgaatct gttttaggtt ctgataatgt agtgattgac
    25681 attcagcaat taacatcaga tgagtttgac agttcaggct actttgctca aacagctgct
    25741 cagaaagatt atgatttata tcatggcggt tggggacctg attatcaaga cccgtcaacc
    25801 tatctcgata tttttaatac taatagtgga ggatttctgc aaaatcttgg actagagcct
    25861 ggtgaggcca atgacaaggc taaggcagtt ggactggatg tctatactca aatgttggaa
    25921 gaagctaata aagagcaaga tccagccaaa cgttatgaga aatatgctga tattcaagct
    25981 tggttgattg atagttcttt agttcttcca agtgtttcgc gtgggggaac accatcattg
    26041 agaagaaccg taccatttgc tgctgcctat ggtttaaccg gtacaaaagg ggttgaatca
    26101 tataaatacc tcaaagtaca agataagatt gtcacaacag acgaatatgc aaaagccaga
    26161 gaaaaatggt tgaaagaaaa agaagaatcc aataaaaaag cccaagaaga attggcaaaa
    26221 catgtcaaat aaaatctaat tgtagataag tttgtgtaag aagtctttgt gcttaaaaac
    26281 gcataatatc aggtatataa aatcctagat gttatgcgtt ttgttatagg aagatttatt
    26341 agattttatc ctcaaattga gttattcccg actttatccg ttgaaatatt ataaggagta
    26401 tttatgaaat taaaattatt aagagtagat actaaggtga ttatggggag tttcttactt
    26461 gttctgtcta gtctacttgc tttgttgctt ccccttatct taaagggttt aatagatggg
    26521 agttctattg aaaatatagg ttccaaagta tttcaatcgt ttttgatttt tattggtcaa
    26581 gccttgtttt cttctattgg ttactatctg tttagtcaat cgggtgaaaa aaagatagca
    26641 aaaatcagga aaaaagtgat agaggggttg atttatgcag agaaatcctt ctttgataag
    26701 agccaaagtg gggagttgac ttctgccatt gtcaatgaca cgagtgtcat tcgtgagttt
    26761 ttaattacga ctttcccaaa tattattctg agtttagtta tggtacttgg ttccattgta
    26821 gtcttattta gtcttgattg gaatctttct ctacttttat tcatcactct tccttgtatg
    26881 atgtttatta tcttgcccct ttccaatatc agtgaaaagt atagtcgtcg tttacaggag
    26941 gaaatttaac agggcaattg actgaaaaga ttcaagaaca tgaattaatt aagactaacc
    27001 aagcagagaa aagtgtacag gatgttttgg ataattgtat tgaaagggta caaaacaatt
    27061 cactgaaatc agatagggtt acttcttttg agacctcgtt tgctctctta tttatctttg
    27121 cgactatagt tgtgatgcta acctatgggg gttatcgggt cagcgcagga tatatatctg
    27181 tgggaacctt ggtttcgttt ttgatttacc tctttcaatt acttaatcct attagtaata
    27241 tagctaattt tgtaactatt tattctagta gcaagggatc ttcagttgca ctggagaact
    27301 tgcttgcagt tcctaaagaa aaatttgagg gaggaaaatc ggtatcagga caagggttga
    27361 attttaacca tgtctatttt ggttatgatg aaaatcgacc tgtcttaaag gatattactt
    27421 gttcaatttt caaggggcaa aaaattgctt ttgttggacc atctggatca ggaaaatcaa
    27481 cgattgtgcg tttgttagag cggttttata aaccgctttc aggatatatt ctaatggagc
    27541 aatcaagtat atatgatttt aacttaaaag aatggagaag taaaatcgct tgggtttcac
    27601 aaaataatgc agtcttatct ggcagtattc gtgacaatct ttgtctcggt ttgaatcgct
    27661 tagtaactga tgatgaattg atgaaagtgc tagacttagt atcactaggt gatgagattc
    27721 gctccatgaa agagggacta gatactgaag ttggtgaacg cggacgactc ttgtcagggg
    27781 ggcgaagcca aagacttcaa atagctagag cctacttaaa agatgctgaa attcttatat
    27841 ttgatgaagc cactgctaat cttgatgcgg attctgagta tgcgattatc agtagcctct
    27901 attctgtact aaaggagaag acggttgtga ttatagcgca tcgtttgtca acggtaaaag
    27961 atgtggattg tattttcttc ttagaggagg ggaaaatcac tggctcagga actcataagg
    28021 aactactgga aaatcatgag cgttatgctc gttttgtgca ggagcaaatg atagagtgaa
    28081 ggtgtctttt gagattcacc attttatagt ctattaaagg gagcaggaaa aactcccttt
    28141 ttatatagtt tgaaactata actagctctt gaaaagaaga aaatgagttg atgaaaataa
    28201 gtggtacaat agttactata gatttggagg aattgtatga gcaaggaatt acacattaac
    28261 acaattttag cacaagcagg gatcaagtct gatgaggcaa caggtgcttt ggtgacacca
    28321 cttcattttt caacgaccta tcagcatcca gagtttggtc gatctactgg gtttgactat
    28381 acgcgcacta aaaatccaac tcgtagtaag gctgaggaag tcttggcggc tattgagtca
    28441 gcagactatg ccctagcgac tagctcaggg atgtcagcta ttgtactggc ctttagcgtc
    28501 tttccagtag gaagtaaggt cttggcagtg cgtgatcttt acggtggttc ttttcgctgg
    28561 tttaaccaag tggagcagga aggtcgtttc cattttacct atgccaatac agaagaagag
    28621 ttgattgccg agttagaaaa ggatgtggat gttctctata tcgaaacccc aaccaatccc
    28681 ttgatgttgg aatttgatat cgaaaaacta gcaaaattgg ctcatgctaa gggtgccaaa
    28741 gtggtggtgg acaatacctt ctatagccct atctaccaac gtccgattga agatggagca
    28801 gatatcgttc tccattcagc aaccaagtat ctagcaggcc ataatgatgt cttggctgga
    28861 gtggttgtga ccaatagttt agaactatac gagaagcttt tttacaatct caatacaaca
    28921 ggggcagtct tgtctccatt tgacagctac cagttgcttc gtggtctcaa gaccttgtct
    28981 cttcgtatgg agcgctcaac agctaacgcc caagaagtgg ttgccttttt gaaggattct
    29041 ccagcagtta aggaagttct ctacactggt cgtggaggca tgatttcctt taaagtagcc
    29101 gatgaaacac gcattcctca tattttgaac agtctcaagg tcttctcttt tgcggaaagt
    29161 ttgggcggag tggaaagtct tattacttat ccaacgactc aaactcatgc tgatattcca
    29221 gcagaagtac gccattctta tggtttgaca gatgacctct tgcgtttgtc tattgggatt
    29281 gaggatacta gagatttgat tgcagatttg cgccaagcct tagaaggata agacaaagat
    29341 gggaaaatat gattttacaa gcctgcccaa ccgtttaggg caccatacct ataaatggaa
    29401 agaaacagaa acggatagtg aagttctacc agcttggata gcggatatgg actttgtggt
    29461 cttgcctgaa atccgccaag ccgtgcaaac ttacgcagac caactggttt atggttatac
    29521 ctatgccagt gaagacttaa ttaaggaagt tcaaaagtgg gaagctacac aatacggtta
    29581 caactttgac aaagaggctc ttgtctttat cgagggtgtg gtaccagcca tctcaacagc
    29641 tattcaaacc tttacaaaag aaggcgaggc ggttttaatt aacacgcctg tctacccacc
    29701 ctttgctcgc agtgtcaagt tgaataatcg tagattgatt actaattcct tagtggaaaa
    29761 ggatagtctg tttgagattg actttgacca acttgaaaag gatttggtgg aagaggaggt
    29821 taaactctat gttctttgca accctcacaa tcctggtgga cgtgtttggg aaaaagaagt
    29881 gttggagaag attggccaac tctgccaaaa acacggtgtt ttgttagttt cggatgagat
    29941 tcaccaagat ttgaccctct ttggtcacaa acaccagtct ttcaatacca tcaatcctgc
    30001 cttcaaaaat tttgctatcg tcttgagcag tgccactaaa acatttaata ttgctggaac
    30061 aaaaaattcc tatgcagtca ttgaaaatcc taagttgaga ctggctttcc agaaacgcct
    30121 gttggccaat aatcagcatg aaatttcagg cttgggttat ttggcgacag aagctgccta
    30181 tcgatacggt aaagattggc tagaggaact caagcaagtc tttgaagacc acatcaatta
    30241 tgtgatggat ctatttggaa aagagactaa aatcaaggtc atgaaaccgc aaggtaccta
    30301 cttgatttgg cttgactttt cagcttatga cctgactgat gaaacattgc aagagttgtt
    30361 gagaaatgaa gccaaggtta tcctcaaccg tggtttggat tttggagagg aaggaagtct
    30421 ccatgcccgc atcaatatag ctatgcccaa atctctgttg caagaagtct gtcagcggat
    30481 tgtggctact tttgccaaac gttaaaaatc cagccttcta ggagaaaagt cttcctagaa
    30541 ggctattttc ataggcgaaa atatggtata ataaaaagat aaggtaaagg tgaaaatatg
    30601 gctaaattga ttccggggaa aattcgtatc gaaggtgttg ccctttatga aactggtaag
    30661 gttgatatca tcaaggaaaa gaacaatcgg ctctacgctc gcgttgcaga agaagaactg
    30721 cgctatagtt tagaggatga tttggttttt tgtgcctgtg attcttttca aaagaggggc
    30781 tactgtgtgc atttggcagc gctagagcat tttctgaaaa atgatgagcg tggtcaggaa
    30841 atcttgtgga gtctggaaga aggtcatgaa gaaaaagagg ccgttgaaac caaggtgacc
    30901 ttgggtggca agtttttgaa tcgaatttta tctccaaaat cagaatgcgc ctatgagtta
    30961 tcagctgtgg gtcaggtgga agcaggaacc aatcatatct tgtggactct gagaatcggc
    31021 caaatcaata gccaaaaata ctatgtcatt cgggatattc tacttttttt aaggattgtc
    31081 gagcagagaa agtcgtatat gattggcaag atttatgagg agtctctttc ttgggaagcc
    31141 tttgatgatg ccagccaaga acttttgact ttcttgcacg gactaacgga ggaagggctg
    31201 gttccagacc tctttttcca aaaccaaggt cggcacctct ttttccctct gacctttttt
    31261 gagcagggtg tgaatttact gatggccttg ccccattttc aatttgacca tcaagtggat
    31321 agctaccaaa ccctgctttt tcaggatatg catgctgatg ccaatctatt tgcctttaca
    31381 gtaacagaat actcggacta ttttgaaatg gaaatcagtg agagtcctag ggtcaatgtc
    31441 ttttatcaag gagcagtact tttccataaa ggtcaggttt attttttaac agaccagcag
    31501 atgcgtcttc tcaaggaaat taaagcgtta cctgtgggtc aacaaggaaa gaaatacctg
    31561 caatttgata gcagtgatcg agacaaattg gcctcctgtc tgactctttt tatccagatg
    31621 ggcaccgttt cagctccaga acgtctacaa attaaaactt ttgcgccctc tttttacttt
    31681 gacagggaag aagataatcg gattcgttta gaaattcagt ttgattatgg aaatagacag
    31741 gtatctagcc gacaagagct agaagaatta ccattttcaa gtgacgcgga cttagaagaa
    31801 agaattttcc aagtctgttt ggctgcgggc tttgaatccg attttcaatc ttggcgtcag
    31861 gccttaaaag cggagtctgt ctatcatttt tttcatgata tcattccagt ctttgaaaaa
    31921 ctcgggcatg ttgacctatc agataaacta gaagagcttt atagcctagc gagtcctcag
    31981 gtgcagattg cttccaaggg aggtctcttg gaaatccagt ttgattttca agatattgcc
    32041 caggaggaaa tcgaccaagc catgcaggcc ttggttgcca atcaggattt ttatattgat
    32101 tcgtctaatc aagtttactt tttcgatgaa gaaaccaaga aaattcgcca aaatctacag
    32161 gaactggggc aatttgaatt aaaagatggg accttgcagg ctcggaaatc cttggcctac
    32221 agtttagctc atctctttga agggcgagac cgtgtttctt tttcacaaga attccagaat
    32281 ctggcccagg atttgacgca tccagaggac tttcctttgc aagcaactca ggtcaaggct
    32341 gacttgcgag attatcagga aaagggaatt ggctggttgc agatgctcca tcattatggt
    32401 tttggtggga ttttggctga tgatatggga cttgggaaaa cccttcagac cattgctttt
    32461 ttgactagtc aagtgacaaa agaaagtcgg gttttgattc tcgctccgtc gggtttgatt
    32521 tacaactggg cagatgagtt tcagaaattt gctccacagt tggatgtggc tgttgttcat
    32581 ggtttgaaag caagtcgtga ggagattctt gccgagagcc atcaaatcta tgtgactagc
    32641 tatgccacct tccgtcagga cagtgagctt tatcagggga tggcctttga cttccttttc
    32701 ttagatgaag ctcaggtcat gaaaaatgcc cagaccaaga ttgcccagac cttgagacaa
    32761 tttgtggtgc cgtcggtctt tgccttgtca ggaactccga ttgaaaacca tctgggtgag
    32821 ttgtggtcta ttttccaaat cgtcatgccc ggacttttgc caagcaagaa agaatttatg
    32881 aaattgccag cagagcgagt ggctcagttt atcaagcctt tcgtgatgcg acgcaagaaa
    32941 gaagaagttc tgactgaatt gccagacttg attgaggtgg tttataaaaa tgaactggaa
    33001 gaccagcaaa aggctattta ccttgcccag ttacaacaga tgcgagacca tctggctcaa
    33061 gtgtcagaac aggaatttca gcgaagtcgt gtggaaattt tatctggttt gatgcgcttg
    33121 cgtcaaatat gtgacactcc tgccctgttt atggaagatt atcagggagc cagcggcaaa
    33181 ctagatagtc tccgagacct actggtacag gtggcagacg gcggacaccg tgtcttgatt
    33241 ttctctcagt tcaagggaat gttggaaaaa attgaacaag aactgccaga cttgggcctg
    33301 acttccttta aaattacggg ttcaacccca gccaaggaaa gacaagacat gaccaaggcc
    33361 tttaatcaag gagaaagaga tgcctttctg atttccctca aggctggtgg ggtcggtctg
    33421 aacctgacag gtgcagatac agtgatcttg gttgaccttt ggtggaatcc tgcggtggaa
    33481 gcgcaagcca ttggccgtgc ccatcggatg ggtcaggaag aaacggttga ggtctatcgc
    33541 ttggtgacca agggaaccat tgaagaaaaa attcaggaac tccaagaaca aaagaaacat
    33601 ctggtgtcac aagtattgga cggcacagag tcacgtggta gtctgaccct agcagaaatt
    33661 agagaaattt tgggaatttc tgaagccagc acttgaaaaa tcaagacaat acgctataat
    33721 gaagtgttga aaggaaatag aaaatgaaac aagaacgatt tccattggtg tcagatgacg
    33781 aggtcatgtt gactgaaatg ccagtcatga atctctatga tgagtctgat ctgatcagta
    33841 atatcaaggg tgagtatcga gataaaaatt atttagaatg ggctcctatt gctgaagaaa
    33901 aaccagtaaa accgattgaa aagcaagtag ggaaacctaa aaaagctcct ttaggggtta
    33961 aaaaagaagg aaagagctat gcggaggtgg cgcgtgaaga agcgcgtgca gacttgaaaa
    34021 agaaacgctc tgctaactat ctaactcagg atttcagcct tgcgagacgt cattctcagc
    34081 ccagtctagt tagacagggc aatcaaccga caactccttt ccaaaaggaa aatcctggtg
    34141 aatttgtcaa atatagccaa aaattgaccc agtctcatta tatcttggcg gaagaagttc
    34201 attctatccc taccaagaat gaagaagtgt cagcacctgc tccaaagaaa aacaattatg
    34261 attttctaaa gaagagccaa atctacaata aaaaaagtaa acaaacagaa caagaacgtc
    34321 gggttgccca agagttgaat ctgaccagaa tgacagaata ggggagaaaa catgtcaaag
    34381 acatatcatt ttatcggaat taagggatca gggatgagtg ccttggcctt gatgttgcac
    34441 cagatggggc acaaggttca gggatcagat gttgaaaagt actactttac ccaacgcggt
    34501 cttgagcagg caggaattac cattcttcct tttgatgaaa agaatctaga cggtgatatg
    34561 gaaattatcg ctggaaatgc ctttcgtcca gataacaacg tcgaaattgc ctatgcggac
    34621 caaaatggta tcagctacaa acgttaccat gagtttctag gtagctttat gcgtgacttt
    34681 gttagcatgg gagtagcagg agcacatgga aaaacttcaa cgacaggtat gttgtctcat
    34741 gtcttgtctc acattacaga taccagcttc ttgattggag atgggacagg tcgtggttcg
    34801 gccaatgcca aatattttgt ctttgaatct gacgaatatg agcgtcactt catgccttac
    34861 cacccagaat actctattat caccaacatt gactttgacc atccagatta tttcacaagt
    34921 ctcgaggatg ttttcaatgc ctttaacgac tatgccaaac aaatcaccaa gggtcttttt
    34981 gtctatggtg aagatgctga attgcgtaag attacgtctg atgcaccaat ttattattat
    35041 ggttttgaag ctgaaggcaa tgactttgta gctagtgatc ttcttcgttc aacaactggt
    35101 tcaaccttca ccgttcattt ccgtggacaa aacttggggc aattccacat tccaaccttt
    35161 ggtcgtcaca atatcatgaa tgcgacagcc gttattggtc ttctttacac agcaggattt
    35221 gatttgaact tggtgcgtga gcacttgaaa acattttccg gtgttaaacg tcgtttcact
    35281 gagaaaattg tcaatgatac agtgattatc gatgactttg cccatcatcc aacagaaatt
    35341 attgcgacct tggatgcggc tcgtcagaaa tacccaagca aggaaattgt agcagtcttt
    35401 caaccgcata cctttacaag aaccattgcc ttgttggacg actttgccca tgctttaaac
    35461 caagcagatg ctatttatct agcgcaaatt tatggctcgg ctcgtgaagt agatcatggt
    35521 gacgttaagg tagaagacct agccaacaaa atcaacaaaa aacaccaagt gattactgtt
    35581 gaaaatgttt ctccactcct agaccatgac aatgctgttt acgtctttat gggagcagga
    35641 gacatccaaa cctatgaata ctcatttgag cgtctcttgt ctaacttgac aagcaatgtt
    35701 caataggatg ttcccatgga aattccaatt aagatcattc aggcaagcaa gtctgatttg
    35761 cctgagatag gggcacttca gacctcgtct tttccagctg aaaagcagca actttcccat
    35821 attttagaag aaagtatccg taagtgtgcg gatacctttc ttctagctag ggatgaaaat
    35881 caacttttag gctatatttt atcaagtccc cagtcagaca atccgcaatg tctaaaagta
    35941 cattctttag tcatcgagtc tgaccatcag agacagggcc tgggaacact tcttcttgca
    36001 gccttgaaag aggtggcagt tgagctggat tacaaaggga ttcgtttgga gagtcctgat
    36061 gagctgcttt cctattttga aatgaacggt tttgttgatg aagaagcaac tttactctat
    36121 gcaactagcc agggctatag tatgatttgg tttaatccct tttatctgga ggaacaatga
    36181 aaatcagaca agcaagatta gaagatttgg atcggattgt tgaacttgaa tttgaaaatt
    36241 tttcggtcga agaagccatt cctccttctg tctttgaagc acatttgaga gaaattcaga
    36301 cctcttttct ggttgctgaa aaagaaggaa gaatcatggg ttatatcgaa ggaccagttg
    36361 gcctgcaccg ccatctgcaa gaccagtctt ttacagaaga aataaaagac tatagtcatg
    36421 agcctggtgg ttatatctct gtgacctgtc tgtctattgc caaggaggca cagggactcg
    36481 gactgggtca gaaattgctg acagccttga aagaagttgc tcttgaagat gagagagatg
    36541 gcattaatct aacctgtcat gactatctca tcgcctatta tgaaaaacat ggatttgtca
    36601 acgaaggcca gtcccagtca acctttgcag gggaaacatg gtatgatatg gtctgggaaa
    36661 tgaaaaaata agttaggaaa agtatcatag attgcttttt ttggactttt aagatataat
    36721 attatggatt atcaacaagg aggaaaaact tttgagtgaa aagtcaagag aagaagagaa
    36781 attaagcttt aaagagcaga ttctgagaga tttagaaaaa gtaaaaggct atgatgaagt
    36841 tctgaaagaa gatgaggcag tagttcgcac tcctgcaaat gaaccttcag ctgaagaact
    36901 catggctgat tccttgtcaa cggtagagga gattatgaga aaagctccta ccgtgcctac
    36961 tcacccaagt caaggtgtac cagcttctcc agcagatgag attcaaagag aaactcctgg
    37021 tgttccaagt catccaagtc aagatgtacc ttcttctcca gcggaagaaa gtggatcaag
    37081 accaggtcca ggtcctgtta gacctaagaa acttgaaaga gaatacaatg aaaccccaac
    37141 aagggtagct gtttcctata cgacggcaga gaaaaaagca gaacaagcag gtccagaaac
    37201 acctacgcct gctatagaaa cagtggatat catcagagat acatcacgtc gtagccgtag
    37261 agaaggagca aaacccgtta agcctaagaa agagaagaag tcacatgtga aagcttttgt
    37321 gatttcattc cttgtattcc ttgccttgct ctcagcaggt ggttactttg gttaccagta
    37381 cgtgctagat tccttattac ctatcgatgc taattctaag aaatatgtga cggttggaat
    37441 tccagaaggt tcaaacgttc aagaaatcgg tacgacgctt gaaaaagctg gtttggtaaa
    37501 gcatggtctg atttttagtt tttatgccaa gtataaaaat tataccgact tgaaagcagg
    37561 ttactacaat ttgcaaaaga gtatgagtac agaagactta ctcaaagagt tgcaaaaagg
    37621 tggaacagat gaaccgcaag aacctgtact tgcgactttg acaattccag aaggttatac
    37681 cttggatcag attgctcaaa ctgtgggtca attgcaaggt gacttcaaag agtctttgac
    37741 agcggaggct ttcttggcta aagttcaaga tgagacgttt atcagtcaag cagtagcgaa
    37801 atatcctact ttactggaaa gtttgcctgt aaaagacagc ggtgcgcgtt atcgtttgga
    37861 aggatacctt ttcccagcta catactctat caaggaaagc acaactattg agagcttgat
    37921 tgatgagatg ttagctgcta tggataagaa cctatctcct tactatagta ctatcaaatc
    37981 taaaaacttg actgtcaatg agttgttgac cattgcttcc ttggtcgaaa aagaaggtgc
    38041 caagacagaa gatcgtaagc tcattgcagg tgtattctac aatcgtttga atcgtgatat
    38101 gccacttcaa agtaatattg caatcttgta tgcccaagga aaactggggc aaaatatcag
    38161 tctagctgag gatgttgcga ttgataccaa cattgattca ccttataatg tttataaaaa
    38221 tgtaggtctc atgcctggtc cagtcgatag tccaagtctg gatgcgattg agtcaagcat
    38281 caatcaaact aagagcgata acctatactt tgtagcagat gtcacagaag gcaaggtcta
    38341 ctatgctaac aatcaagaag accacgaccg caatgtcgct gaacatgtca acagcaaatt
    38401 aaactaaaca aactaaaatt atgtgatact tcacataatt ttctttagaa aatattatca
    38461 gaagaaagtt gagaaaaatg gcagaaaaaa catatcctat gacccttgag gaaaaggaga
    38521 aacttgaaaa agaattagaa gaattgaaat tggttcgtcg accagaagtg gtagaacgca
    38581 ttaagattgc ccgttcatac ggtgatcttt cagaaaacag tgagtacgaa gcagctaagg
    38641 atgaacaagc ctttgtcgaa ggacaaatct ctagcttaga aacaaaaatc cgctatgctg
    38701 aaatcgtcaa tagcgacgca gttgcccagg acgaagtagc gattggtaaa acagtcacca
    38761 tccaagaaat tggtgaggac gaagaagaag tttatattat cgtaggttca gctggtgcgg
    38821 atgcctttgc aggtaaggtt tcaaatgaaa gcccaattgg gcaggccttg attggcaaga
    38881 aaacaggtga cacagcaacc attgaaacgc ctgttggtag ctatgatgta aaaatcttga
    38941 aggttgaaaa aacagcctaa aaacagaaaa aggagtgggg aggcgatgtg cttcactcac
    39001 tcctttttcc attttgctat tcttcgaaaa tctcttcaaa ccacgtcagc gtcgccttgc
    39061 cgtatgtatg gttactgact ttgtcagttt cat
//
LOCUS       DAVHSO010000015        36813 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.015, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000015 DAVHSO010000000
VERSION     DAVHSO010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 36813)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36813)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36813
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.015"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            67..714
                     /locus_tag="VVR18_000710"
     CDS             67..714
                     /locus_tag="VVR18_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="HEU6032280.1"
                     /translation="MDFEYFYNREAERFNFLKVPEILVDREEFRGLSAEAIILYSILL
                     KQTGMSFKNNWIDKEGRVFIYFTVEEIMKRRNISKPTAIKTLDELDVKKGIGLIERVR
                     LGLGKPNIIYVKDFMSIFQVKENDLQKSKNLTSEVKDFNLRSKENELQEVKNLDSNYI
                     ENNKSKYSKREYSFGENGLGTFQNVFLAAEDISDLQIIMNSQLENYIRLPAKLES"
     gene            complement(703..1506)
                     /locus_tag="VVR18_000711"
                     /pseudo
     CDS             complement(703..1506)
                     /locus_tag="VVR18_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            1501..1755
                     /locus_tag="VVR18_000712"
     CDS             1501..1755
                     /locus_tag="VVR18_000712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HEU6032281.1"
                     /translation="MHRTTIPYFVSQEVYWKVRNIEAEAIRRNCERGAIFSGKIKYHE
                     DSQFKGDHYVECYAVLDNTVIARDRITVPIDPLCGKDFIE"
     gene            2000..3334
                     /gene="trmFO"
                     /locus_tag="VVR18_000713"
     CDS             2000..3334
                     /gene="trmFO"
                     /locus_tag="VVR18_000713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HEU6032282.1"
                     /translation="MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHK
                     TDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGF
                     SQMVTEKVVNHPLIEVVRDEITELPTDVITVVATGPLTSDALAEKIHALNNGDGFYFY
                     DAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSF
                     EKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQ
                     DNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQT
                     YRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEAIFPETTAIGSLAH
                     YITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV"
     gene            3418..4155
                     /locus_tag="VVR18_000714"
     CDS             3418..4155
                     /locus_tag="VVR18_000714"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HEU6032283.1"
                     /translation="MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSL
                     GIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQ
                     TAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRSAEIEADAILM
                     AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNM
                     NQSGNIKRVVFGENIGTTVSNNIEEKE"
     gene            4164..4721
                     /gene="frr"
                     /locus_tag="VVR18_000715"
     CDS             4164..4721
                     /gene="frr"
                     /locus_tag="VVR18_000715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HEU6032284.1"
                     /translation="MANAIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEY
                     YGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDLGITPANDGSVIRLVI
                     PALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKQEKAKEITEDELKTLEKDI
                     QKVTDDAVKHIDDMTANKEKELLEV"
     gene            4781..5635
                     /gene="cvfB"
                     /locus_tag="VVR18_000716"
     CDS             4781..5635
                     /gene="cvfB"
                     /locus_tag="VVR18_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding virulence regulatory protein CvfB"
                     /protein_id="HEU6032285.1"
                     /translation="MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDT
                     VKGFAYTDMKQKLRLTTLEVTATQDQFGWGCVTEVRKDLGVFVDTGLPDKEIVVSLDI
                     LPEFKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQNWPAIVY
                     RLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSF
                     EMLENDAQMILTYLESNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQ
                     DQFGTELI"
     gene            5644..5859
                     /locus_tag="VVR18_000717"
     CDS             5644..5859
                     /locus_tag="VVR18_000717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YozE family protein"
                     /protein_id="HEU6032286.1"
                     /translation="MRKSFYTWLMTERNPKSNSPKAILADLAFEEAAFPKHTDDFDEV
                     SRFLEEHASFSFNLGDFDSIWQEYLEH"
     gene            5945..6913
                     /locus_tag="VVR18_000718"
     CDS             5945..6913
                     /locus_tag="VVR18_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HEU6032287.1"
                     /translation="MKEHSIDIQLSHPDDLFHLFGSNERHLRLMEEELDVVIHARTEI
                     VQVLGEESACEEARQVIQALMVLVNRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEI
                     IKDNTGKPIRVKTLGQKLYVDSVKQHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKR
                     IILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKDQTTRLMEREIIEIAP
                     LAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFHSKMIVNGDISQIDLPRNVKSG
                     LIDAQEKLKNIHQIDFVHFSAKDVVRHPVVAQIIRAYEYSTEVAHD"
     gene            complement(6891..7070)
                     /locus_tag="VVR18_000719"
     CDS             complement(6891..7070)
                     /locus_tag="VVR18_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032288.1"
                     /translation="MTQEDALIVISHIKVLSIVPNRCLRPLDKTFSLYNWIFLSQKYI
                     LLQANFLKISRVQLQ"
     gene            7106..7606
                     /locus_tag="VVR18_000720"
     CDS             7106..7606
                     /locus_tag="VVR18_000720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032289.1"
                     /translation="MIDQLSKYYSCRILTEKDIPSILSLYESNPLYFQHCPPEPNFAT
                     VKEDMLCLPEGKAKADKFFVGFWNGSDLVAVMDFVYAYPDEETVFIGLFMVDQAYQRK
                     GIGSHIVTEALAYFAKNFRKARLAYVKGNPQSQHFWEKQGFKSIGCEVKQELYTVVIA
                     EQSLED"
     gene            7609..7869
                     /locus_tag="VVR18_000721"
                     /pseudo
     CDS             7609..7869
                     /locus_tag="VVR18_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003069408.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TfoX/Sxy family protein"
     gene            complement(8236..8562)
                     /locus_tag="VVR18_000722"
     CDS             complement(8236..8562)
                     /locus_tag="VVR18_000722"
                     /inference="COORDINATES: protein motif:HMM:NF013430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032290.1"
                     /translation="MVDVAVDQGGVIETADRVTTHDEPVYEKHGVLHYAVANIPGAVA
                     RTSTIALTNVTLPYIEALAGKGFAQAISEDEGLRQGVTTYQGYLTNLPVAQGLNRDYT
                     DINDLV"
     gene            complement(8508..8921)
                     /locus_tag="VVR18_000723"
     CDS             complement(8508..8921)
                     /locus_tag="VVR18_000723"
                     /inference="COORDINATES: protein motif:HMM:NF013430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-binding protein"
                     /protein_id="HEU6032291.1"
                     /translation="MGAHFLTKQAGGSGVLLGGVPGVPKGKVTIIGDGVVGTHAARIA
                     LGLGAQVTILDISAKRLSVLEEVFGSQIQTLMSNSFNIEASVRDADVVIGAILIPGAK
                     APELVTDEMVKQMRPGSVSLTLLLTKVALSKQLTV"
     gene            complement(8922..9347)
                     /locus_tag="VVR18_000724"
     CDS             complement(8922..9347)
                     /locus_tag="VVR18_000724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine dehydrogenase"
                     /protein_id="HEU6032292.1"
                     /translation="MLIGIPKEIKNNENRVALTPAGVHSLVSRGHRVLIETNAGLGSG
                     FTDADYQKQGAEIVATAGEAWAAELVVKVKEPLSSEYGYLRDDLLLFTYLHMAAAPEL
                     ADAMLAAKTTGIAYETVRDNQGQLPLLVPMSEVAGRMAV"
     gene            9524..10093
                     /locus_tag="VVR18_000725"
     CDS             9524..10093
                     /locus_tag="VVR18_000725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032293.1"
                     /translation="MESIFVKLAQYPSIETERLLLRPVTLDDAEAMFDYASDKGNTRY
                     TFPTNQSLEETKNNIAQFYLANPLGRWGIELKSNGKFIGTIDLHKIDPVLKKVAIGYI
                     INQTYWNQGLTTETNRAVIELAFEKIGMNKLVALYDKANPASGKVMEKSGMRFSHAEP
                     YACMDQHEKGRIVTRVHYVLTKEDYFANK"
     gene            10161..10811
                     /locus_tag="VVR18_000726"
     CDS             10161..10811
                     /locus_tag="VVR18_000726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HEU6032294.1"
                     /translation="MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQ
                     AEVAAVSKDLVSEEEVNKEEKEEPLEQDLITVDVKGAVKSPGIYDLPVGSRVNDAVQK
                     AGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
                     SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD"
     gene            10795..13035
                     /locus_tag="VVR18_000727"
     CDS             10795..13035
                     /locus_tag="VVR18_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA internalization-related competence protein
                     ComEC/Rec2"
                     /protein_id="HEU6032295.1"
                     /translation="MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCL
                     FIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQNLADSVERVRILPDTIKVNGDSL
                     SFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
                     LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLL
                     GHLDTDFEEMSELYSSLGIIHLFALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPF
                     SLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIVMPNFFLTAGGVLSC
                     AYAFILTMTSKEGKGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDL
                     TFLPLLSILFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWLLILLLI
                     SLALVYDLRKNIKGLTVLSLLITGLFFLTKYPLENEITMLDVGQGESIFLRDVTGKTI
                     LIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDKEHVGDL
                     SEVTKAFHVGEILVSKDSLKQKEFVAELQVTQTKVRSMTVGEYLPIFGSQLEVLSPRE
                     IGYGGHEDSLVLYGKLLNNHFLFIGNLEEKGEKDLLKYYPDLKVNVLKASQHGNKKSS
                     SPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGINSKVYRTDQQGAIRFKGLDSW
                     KIESVR"
     gene            13177..13401
                     /locus_tag="VVR18_000728"
     CDS             13177..13401
                     /locus_tag="VVR18_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032296.1"
                     /translation="MIIGLFQSSISAVTVTKSYKYDWNTVWEYSTNYHDHQYAWIPSW
                     SRYDSYSEYPVGSGWNYGRYEVINYYSGGY"
     gene            13433..14020
                     /locus_tag="VVR18_000729"
     CDS             13433..14020
                     /locus_tag="VVR18_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000939891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032297.1"
                     /translation="MLNLTHVTLKTRQVILQDADFTFKKGRIYGLLAINGSGKTTLFR
                     AISNLIPISSGNIAAPPSLFYYESIEWLDGNLSGMDYLRLIKNIWKSGLNLRDEIAYW
                     EMSDYISLPIRKYSLGMKQRLVIAMYFLSQAKCWLMDEITNGLDEYYRQKFFDRLAQI
                     DRQEQLVLLSSHYKEELVDVCDRVVTIHQGQIEEV"
     gene            14024..15208
                     /locus_tag="VVR18_000730"
     CDS             14024..15208
                     /locus_tag="VVR18_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032298.1"
                     /translation="MKDVSLFLLKKVFKSRLNWIILLLFASVLGVTFYLNSQTANSHS
                     LESRLESRIAANERAINENEEKLSQMSDTSSEEYQFAKNNLDVQKNLLTRKTEILTLL
                     KEGRWKEAYYLQWQDEEKNYEFVSNDPTAISGLKMGVDRERKIYQALYPLNIKAHTLE
                     FPTHGIDQIVWILEVIIPSLFVVAIIFMLTQLFAERYQNHLDTAHLYPVSKVTFAISS
                     LGVGVGYVTVLFIGICGFSFLVGSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFPG
                     LLLAFLAFIVIVEVVYLIAYFFKQKMPVLFLSLIGIVGLLFGIQTIQPLQRIAHLIPF
                     TYLRSVEILSGRLSKQIDNVDLNWSMGMVLLPCLIIFLLVGILFIENWGSSRKKEVFN
                     RS"
     misc_feature    15363..15494
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            15510..16040
                     /gene="infC"
                     /locus_tag="VVR18_000731"
     CDS             15510..16040
                     /gene="infC"
                     /locus_tag="VVR18_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HEU6032299.1"
                     /translation="MKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADN
                     ANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGD
                     FDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPATDKK"
     gene            16073..16273
                     /gene="rpmI"
                     /locus_tag="VVR18_000732"
     CDS             16073..16273
                     /gene="rpmI"
                     /locus_tag="VVR18_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HEU6032300.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHL
                     RKASMVHSGDYKRIKAMLTRLK"
     gene            16325..16684
                     /gene="rplT"
                     /locus_tag="VVR18_000733"
     CDS             16325..16684
                     /gene="rplT"
                     /locus_tag="VVR18_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HEU6032301.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVND
                     AVAFTALADAAKAKLGK"
     gene            16742..17122
                     /locus_tag="VVR18_000734"
     CDS             16742..17122
                     /locus_tag="VVR18_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU6032302.1"
                     /translation="MASKMLHTCLRVENLEKSIAFYQDAFGFKELRRRDFPDHAFTIV
                     YLGLEGDDYELELTYNYDHGPYVVGDGFAHIALSTPDLEALHQEHSAKGYEVTEPNGL
                     PGTTPNYYFVKDPDGYKVEVIREK"
     gene            17372..18172
                     /locus_tag="VVR18_000735"
     CDS             17372..18172
                     /locus_tag="VVR18_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HEU6032303.1"
                     /translation="MNLTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRA
                     GQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMG
                     PQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILK
                     TELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHP
                     RAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL"
     gene            18135..19121
                     /locus_tag="VVR18_000736"
     CDS             18135..19121
                     /locus_tag="VVR18_000736"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HEU6032304.1"
                     /translation="MVLFSAQEQLYYKEKIMTTNRLQVSLPGLDLKNPIIPASGCFGF
                     GQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAE
                     KLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGL
                     LIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVG
                     MRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSAEAALEM
                     YLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR"
     gene            19163..21328
                     /gene="lytB"
                     /locus_tag="VVR18_000737"
     CDS             19163..21328
                     /gene="lytB"
                     /locus_tag="VVR18_000737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endo-beta-N-acetylglucosaminidase"
                     /protein_id="HEU6032305.1"
                     /translation="MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASD
                     GTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYFHLKSGGY
                     MAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKA
                     DGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFY
                     IKENGNYADKEWIFENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKIAEKEWVYDS
                     HSQAWYYFKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYM
                     TANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFY
                     LKSDGKMAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSDGKWLGGKATNENAA
                     YYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTEDLQ
                     ALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLE
                     NPFLFKDLTEATNYSAEELDKVFSLLNINNSLLENKGATFKEAEEHYHINALYLLAHS
                     ALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILGATKWIKENYIDRGR
                     TFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKD"
     gene            complement(21389..23044)
                     /gene="pavA"
                     /locus_tag="VVR18_000738"
     CDS             complement(21389..23044)
                     /gene="pavA"
                     /locus_tag="VVR18_000738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094859469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rqc2 family fibronectin-binding protein PavA"
                     /protein_id="HEU6032306.1"
                     /translation="MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQ
                     SHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEM
                     TVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGS
                     TYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEK
                     LSAFRNFFNQETKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQA
                     SELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILD
                     NYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVET
                     VLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQN
                     EELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQ
                     VDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS"
     gene            23149..23646
                     /gene="ybeY"
                     /locus_tag="VVR18_000739"
     CDS             23149..23646
                     /gene="ybeY"
                     /locus_tag="VVR18_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HEU6032307.1"
                     /translation="MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVT
                     NERSHELNLEYRDTDRPTDVISLEYKPELEIAFDEEDLLENPELAEMMSEFDAYIGEL
                     FISIDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFGLQEEILTAY
                     GLTRQ"
     gene            23627..24022
                     /locus_tag="VVR18_000740"
     CDS             23627..24022
                     /locus_tag="VVR18_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000378166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HEU6032308.1"
                     /translation="MDSQDNKRKWKNRDLISSLEFAITGIFTAIKEERNMRKHAVTAL
                     VVILAGFVFQVSRIEWLFLLLSIFLVVAFEIINSAIENVVDLASHYHFSMLAKNAKDM
                     AAGAVLVVSLFAALTGALIFLPRIWDLLF"
     gene            24039..24938
                     /gene="era"
                     /locus_tag="VVR18_000741"
     CDS             24039..24938
                     /gene="era"
                     /locus_tag="VVR18_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HEU6032309.1"
                     /translation="MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKI
                     MGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGD
                     DMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
                     LVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMK
                     RDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWV
                     KVKKNWRDKKLDLADFGYNEREY"
     gene            24987..25811
                     /gene="mutM"
                     /locus_tag="VVR18_000742"
     CDS             24987..25811
                     /gene="mutM"
                     /locus_tag="VVR18_000742"
                     /EC_number="3.2.2.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001114577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="HEU6032310.1"
                     /translation="MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRE
                     LPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGG
                     TLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQAALAKSKKPIKSH
                     LLDQTLVAGLGNIYVDEVLWRAQVHPARPSQSLTAEEATAIHDQTIAVLGQAVEKGGS
                     TIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD"
     gene            25811..26416
                     /locus_tag="VVR18_000743"
     CDS             25811..26416
                     /locus_tag="VVR18_000743"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HEU6032311.1"
                     /translation="MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGG
                     RLFEALVQHFGQEIILENGELNRPLLASLIFSNPEEQKWSKQIQGEIIREELATLREQ
                     LAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAA
                     QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD"
     gene            26403..27602
                     /locus_tag="VVR18_000744"
     CDS             26403..27602
                     /locus_tag="VVR18_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HEU6032312.1"
                     /translation="MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSEQ
                     VAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYW
                     LIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAE
                     LFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLF
                     LTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDK
                     VGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPK
                     AGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYYAVFYATSLCVAFSCLFNLIQFRT
                     LLKVKEI"
     gene            27602..27751
                     /gene="rpmG"
                     /locus_tag="VVR18_000745"
     CDS             27602..27751
                     /gene="rpmG"
                     /locus_tag="VVR18_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEU6032313.1"
                     /translation="MRVKINLKCSSCGSINYLTSKNSKTHPDKIEVLKYCPKERKVTL
                     HLESK"
     gene            27791..28024
                     /gene="secG"
                     /locus_tag="VVR18_000746"
     CDS             27791..28024
                     /gene="secG"
                     /locus_tag="VVR18_000746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HEU6032314.1"
                     /translation="MYNLLLTILLVLSVVIVIAIFMQPTKNQSSNVFDASSGDLFERS
                     KARGFEAVMQRLTGILVFFWLAIALALTVLSSR"
     gene            28126..30480
                     /gene="rnr"
                     /locus_tag="VVR18_000747"
     CDS             28126..30480
                     /gene="rnr"
                     /locus_tag="VVR18_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HEU6032315.1"
                     /translation="MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMER
                     KHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAI
                     DGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQGKPKYVGYIRSKNQ
                     KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVL
                     ESMDIVSEFPEAVVKEAESVPDAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIK
                     ALKNGNLELGVHIADVSYYVTEVSALDKEALNRATSVYVTDRVVPMLPERLSNGICSL
                     NPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHK
                     IVSSIELMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIE
                     SFMLMANETVAEHFSKLDLPFIYRIHEEPKAEKVQKFIDYASSFGLRIYGTASEISQE
                     ALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSPIRRYPD
                     LLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYV
                     GEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVG
                     QQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSRSGRGRGSNRRSDKKEDKRKS
                     GRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK"
     gene            30443..30910
                     /gene="smpB"
                     /locus_tag="VVR18_000748"
     CDS             30443..30910
                     /gene="smpB"
                     /locus_tag="VVR18_000748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HEU6032316.1"
                     /translation="MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARI
                     NLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLYKKQIQKLEQETKGTG
                     MTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR"
     gene            30926..31786
                     /gene="tehB"
                     /locus_tag="VVR18_000749"
     CDS             30926..31786
                     /gene="tehB"
                     /locus_tag="VVR18_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase TehB"
                     /protein_id="HEU6032317.1"
                     /translation="MEKLVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGAIK
                     FIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKY
                     NTNPVHSEVLEAMQTVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSI
                     VEQEDLDMPVGLYDINSASIEQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYN
                     LIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLR
                     FATLLAKKIK"
     gene            31859..32812
                     /gene="coiA"
                     /locus_tag="VVR18_000750"
     CDS             31859..32812
                     /gene="coiA"
                     /locus_tag="VVR18_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein CoiA"
                     /protein_id="HEU6032318.1"
                     /translation="MFVARDARGELVNVLEDKLEKQAYTCPACGGQLHLRQGPSVRTH
                     FAHKSLKDCDFFFENESPEHLANKESLYHWLKKETKVQLEYPLSELKQIADVFVNGNL
                     DLEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
                     YVWELDKEKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKRQKISHFTV
                     SEDKDICRYIRQQLYYQNLFWMKEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIE
                     QDLTNYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVK"
     gene            32831..34633
                     /gene="pepF"
                     /locus_tag="VVR18_000751"
     CDS             32831..34633
                     /gene="pepF"
                     /locus_tag="VVR18_000751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEU6032319.1"
                     /translation="MVLQRNEINEKDTWDLSTIYPTDQAWEEALKDLTEQLETVAQYE
                     GHLLDSADNLLEITEFSLEMERQMEKLYVYAHMKNDQDTREAKYQEYYAKAMTFYSQL
                     DQAFSFYEPEFMEISEKQYADFLEAQPKLQVYQHYFDKLLQGKDHVLSQREEELLAGA
                     GEIFGSASETFAILDNADIVFPYVLDDDGKEVQLSHGIYTRLMESKKREVRRGAYQAL
                     YATYEQFQHTYAKTLQTNVKVQNYRAKVRNYKSARHAALAANFVPESVYDNLVAAVRK
                     HLPLLHRYLELRSKILGISDLKMYDVYTPLSSVEYSFTYQEALKKAEDALVVLGEDYL
                     SRVKRAFSERWIDVYENQGKRSGAYSGGSYDTNAFMLLNWQDNLDNLFTLVHETGHSM
                     HSSYTRETQPYVYGDYSIFLAEIASTTNENILTEKLLEEVEDDATRFAILNNFLDGFR
                     GTVFRQTQFAEFEHAIHQADQNGEVLTSDFLNKLYADLNQEYYGLSKEDNPEIQYEWA
                     RIPHFYYNYYVYQYSTGFAAASALAEKIVHGSQEDRDRYIDYLKAGKSDYPLNVMRKA
                     GVDMEKEDYLNDAFAVFERRLNEFEALVEKLGLA"
     gene            34635..35348
                     /locus_tag="VVR18_000752"
     CDS             34635..35348
                     /locus_tag="VVR18_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HEU6032320.1"
                     /translation="MVESYSKNANHNMRRPVVKEEIVDLMRQRQKQVTGFLKELEDFA
                     RKENIPIIPHETVAYFRFLMETMQPKNILEIGTAIGFSALLMAEHAPNAKITTIDRNP
                     EMIGFAKENFAQFDSRKQITLLEGDAVDVLSTLTESYDFVFMDSAKSKYIVFLPEILK
                     HLEVGGVVVLDDIFQGGDVAKDIMEVRRGQRTIYRGLQKLFDATLDNPELTATLVPLG
                     DGILMLRKKVADVQLSESE"
     gene            35415..36356
                     /gene="prsA"
                     /locus_tag="VVR18_000753"
     CDS             35415..36356
                     /gene="prsA"
                     /locus_tag="VVR18_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HEU6032321.1"
                     /translation="MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFY
                     EQVKSNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAG
                     MTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAK
                     EVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGV
                     SDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIG
                     KELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE"
     gene            complement(36473..>36813)
                     /locus_tag="VVR18_000754"
     CDS             complement(36473..>36813)
                     /locus_tag="VVR18_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU6032322.1"
                     /translation="LEQAFKEKHYENTILHSDQDWQYQHDSYHRFLESKGIQASMSRK
                     GNSQDNGRMESFFGILKSEMFYGYEKTFKSLNQLEQAIIDYIDYYNNKRIKVKLKGLS
                     PVQYRTKSFG"
BASE COUNT        11116 a         6811 c         8240 g        10646 t
ORIGIN      
        1 aaaggcgata gaagaaaaac tatcgtcttt ttctttgcaa atttttaaga agggaggtga
       61 tcttgcatgg actttgaata tttttataac agagaagcgg aaagatttaa cttcttaaaa
      121 gtaccggaga tattagttga tagagaagaa tttcggggct tatcagcaga agcaattatc
      181 ctttattcca tacttcttaa acagacagga atgtcattta agaataactg gatagacaag
      241 gaaggcagag tatttatcta ttttactgtc gaagaaatta tgaaaagaag aaatatctca
      301 aagccaactg ccataaaaac attagatgag cttgatgtaa aaaaaggaat aggactgatc
      361 gaaagagtaa ggcttggact tggtaagccg aacatcattt atgttaaaga ctttatgagt
      421 atatttcagg taaaagaaaa tgacttacag aagtcaaaaa acttaacttc agaagtaaaa
      481 gattttaacc tcagaagtaa agaaaatgaa cttcaagagg ttaagaacct tgactctaac
      541 tatatagaga ataataagag taagtatagt aagagagaat atagttttgg tgaaaacgga
      601 cttggaacat ttcaaaatgt gtttttagct gctgaagata tatcggattt acaaatcata
      661 atgaactcac agcttgagaa ttacattaga cttcctgcaa aactagaatc ctagttcatg
      721 attgataata ccagcaatca aattcattcg taatccgaag cgtttacgat gatttcgata
      781 ggttgttgaa aacattttaa acgtttttac tttggcaaag atgttctcaa ccttgcttct
      841 ctccttagat agcgcatggt tacaggcttt atcttcagct gttagcggct tgagtttgct
      901 ggatttacgt ggagtttgtg cttgaggata tatcttcatg agcccttgat aaccactgtc
      961 ggccaagatt ttaccagctt gtccgatatt tctgcaactc attttgaaca acttcatatc
     1021 atgactatag ttcacagtga tatccaaaga aacaattctc ccttgacttg tgacaatcgc
     1081 ttgagccttc atagcgtgaa atttcttttt accagaatga ttcgctaatt gtttttttag
     1141 ggcgattgat ttgtacttcc gtcgcatcaa tcattaccgt gtcctcagaa ctgagaggag
     1201 ttcttgaaat cgtaacacca ctttgaacaa gagttacttc aacccattgg ctccgacgga
     1261 ttaagttgct ttcgtgaata ccaaaatcag ccgcaatttc ttcataagtt cgatattctc
     1321 gcacatatag aagagtggcc ataagaaggt cttctaggct taatttaggt tttcgtccac
     1381 cttttgcgtg tttaagttga taagctgttt taatacagct aatatctctt caaaagtcgt
     1441 gcgctgaaca ccaacaagac gcttaaatcg tgcatcagtt agttgtttac ttgcttcatc
     1501 attcatagaa ctactatacc atattttgtt tcgcaggaag tctattggaa agtaagaaat
     1561 attgaagctg aggctattag aagaaattgt gagcgtggtg ctattttttc aggtaaaata
     1621 aaatatcacg aagattcaca gtttaaagga gatcactatg ttgaatgtta tgctgtttta
     1681 gataatacgg ttatagcaag agatagaata acagtcccta tcgatccgtt atgtggaaaa
     1741 gattttatag agtagcatat aattgattct taactggaat actcactatc tctttacatc
     1801 aagaaaatga ctaaacaggg aagtttgcct tcttcccttt ttttgttata ctagtagaag
     1861 aaaaaataga aagatttgtg ggagtgaaaa agtcctgtgg actttttcag cctgagccaa
     1921 gaaactcgaa atctcgtaag tctgattggc tttttcaatg tgaatcttaa cttcacactc
     1981 ccaaagaggt attagtgtcg tgtctcaatc ttatatcaat gttatcggtg ctggtttggc
     2041 aggttctgaa gcagcttacc aaatcgcaga gcgtggtatt ccagttaaac tttatgaaat
     2101 gcgtggtgtc aagtcgactc ctcagcacaa aacagacaat tttgctgagt tggtttgttc
     2161 caattctttg cgtggggatg ctttgacaaa tgcagttggt cttctcaagg aagaaatgcg
     2221 tcgcttgggt tctgttatct tggaatctgc tgaggctaca cgtgttcctg ccggtggagc
     2281 ccttgcggtg gatcgtgatg gtttctctca aatggtgacc gaaaaagtgg tcaaccaccc
     2341 cttgattgaa gtggtgcgtg atgaaattac agaattgcca acagatgtta ttacagttgt
     2401 ggcgactggt cccttgacta gcgatgccct ggctgaaaag attcatgccc ttaataatgg
     2461 cgatggcttc tatttctacg atgcagcagc gcctattatc gatgtcaaca ctatcgatat
     2521 gagtaaggtc tatctcaaat ctcgttatga taagggagaa gcagcctatc tcaatgctcc
     2581 aatgaccaag caagagttta tggatttcca tgaagccttg gtcaatgcgg aagaagcacc
     2641 gctcaattct tttgaaaaag aaaagtactt tgaaggatgt atgccaatcg aagttatggc
     2701 caaacgtggc attaaaacta tgctttatgg ccctatgaag ccagtcggtc ttgagtatcc
     2761 ggacgactac acaggacctc gtgatggaga atttaaaaca ccttatgcgg ttgtgcaact
     2821 tcgtcaggat aatgcagctg gtagcctcta caatattgtt ggtttccaga cccacctcaa
     2881 atggggagaa caaaagcgtg tcttccaaat gattccgggt cttgaaaatg cggagtttgt
     2941 ccgttatggt gtcatgcatc gcaattctta catggattca ccaaatcttc ttgagcagac
     3001 ttaccgttct aagaaacaac caaatctctt ctttgctggt cagatgacgg gtgtggaagg
     3061 ctatgttgag tcggcggctt caggcttagt tgcgggaatt aacgcagctc gtctcttcaa
     3121 ggaagaaagc gaggctattt tccccgagac gacagcgatt ggaagcttag ctcattacat
     3181 tacccatgcc gacagcaaac atttccaacc aatgaatgtc aattttggga tcatcaagga
     3241 gttggaaggc gagcgtatcc gtgataagaa ggctcgttat gaaaaaattg cagagcgtgc
     3301 ccttgccgac ttagaggaat ttttgactgt ctaatttttt tgaaagaatt gctcatgata
     3361 ctataaaaat cttagaaatt gtgataaaat aggtaggatg aaagaaggag agtgaaaatg
     3421 gcgaatccca agtataaacg tattttaatc aagttatcag gtgaagccct tgccggtgaa
     3481 cgtggcgtag ggattgatat ccaaacagtt caaacaatcg caaaagagat tcaagaagtt
     3541 catagcttag gtatcgaaat tgcccttgtt atcggtggag gaaatctctg gcgtggagaa
     3601 cctgcagcag aagcaggtat ggaccgtgtt caggcagatt acactggaat gcttgggact
     3661 gttatgaatg ctcttgtgat ggcagattca ttgcaacaag ttggggttga tacacgtgtt
     3721 caaacagcta ttgccatgca acaagtggca gagccttatg tacgtggacg tgctcttcgc
     3781 caccttgaaa aaggccgtat cgttatcttt ggtgctggaa ttggttcacc ttacttctca
     3841 accgatacaa cagcggctct tcgttcagct gaaatcgaag cggatgccat tcttatggct
     3901 aaaaatggtg tcgatggtgt gtacaatgcc gatcctaaga aagataagac agctgttaag
     3961 tttgaagaat tgacccaccg tgacgttatc aataaaggtc ttcgtatcat ggactcaaca
     4021 gcttcaaccc tctcaatgga caacgacatt gacttggttg tcttcaacat gaaccaatca
     4081 ggcaacatca aacgtgtcgt atttggtgaa aatatcggaa caacagtttc aaataatatc
     4141 gaagaaaagg aataagaaag aatatggcta acgcaattat tgaaaaagct aaagagagaa
     4201 tgacccagtc tcaccaatca cttgctcgtg aatttggtgg tatccgtgct ggccgtgcca
     4261 atgcaagctt gcttgaccgt gtacatgtag aatactatgg agtcgaaact cctcttaatc
     4321 aaatcgcttc aattacgatt ccagaagcgc gtgttttgtt ggtaacacca tttgacaagt
     4381 cttcattgaa agacatcgaa cgtgccttga acgcttctga tcttggtatc acaccggcta
     4441 atgacggttc tgtgattcgc ttggttatcc cagctcttac agaagaaact cgtcgtgacc
     4501 ttgctaaaga agtgaagaag gtcggcgaaa atgctaaagt ggctgtccgc aatatccgtc
     4561 gcgatgctat ggacgaagct aagaaacaag aaaaagcaaa agaaatcact gaagacgaat
     4621 tgaagactct tgaaaaagac attcaaaaag taacagacga tgctgttaaa cacatcgacg
     4681 atatgactgc caacaaagag aaagaacttt tggaagtcta aaaataaaca gaaaaactca
     4741 gttggcattg ctggctgagt tttattcgaa agaaggaaat atgaatacaa atcttgcaag
     4801 ttttatcgtt ggactgatca tcgatgaaaa tgaccgtttt tactttgtgc aaaaggatgg
     4861 tcaaacctat gctcttgcta aggaagaagg tcaacataca gtaggggata cggtcaaagg
     4921 ttttgcatac acggatatga agcaaaaact ccgcctgaca accttagaag tgactgccac
     4981 tcaggaccaa tttggttggg gatgtgtcac agaggttcgt aaggacttgg gtgtctttgt
     5041 ggatacaggc cttcctgaca aggaaatcgt tgtgtcactc gatattctcc ctgagttcaa
     5101 ggaactctgg cctaagaagg gcgaccaact ctacatccgt cttgaagtgg ataagaaaga
     5161 ccgtatctgg ggcctcttgg cttatcaaga agacttccaa cgtctcgctc gtcctgccta
     5221 caacaacatg cagaaccaaa actggccagc cattgtttac cgtctcaagc tgtcaggaac
     5281 ttttgtttac ctaccagaaa ataatatgct tggttttatt catcctagcg agcgttacgc
     5341 agagccacgt ttggggcaag tattagatgc gcgcgttatt ggtttccgtg aagtggaccg
     5401 cactttgaac ctctccctca aaccacgctc ctttgaaatg ttggaaaacg atgctcagat
     5461 gattttgact tatttggaaa gcaatggcgg tttcatgacc ttaaatgaca agtcatctcc
     5521 agacgacatc aaggcaacct ttggcatttc taaaggtcag ttcaagaaag ctttaggtgg
     5581 tcttatgaag gctggtaaaa tcaagcagga ccagtttggg acagagttga tttagggagg
     5641 tttatgagaa aatcatttta cacttggctc atgaccgagc gcaatcctaa aagtaacagt
     5701 cccaaagcaa ttttggcaga cctcgctttt gaagaggcag cttttccaaa acatacagat
     5761 gattttgatg aggtcagtcg ctttttggag gagcatgcca gtttctcttt taacctagga
     5821 gattttgaca gcatttggca ggaatatcta gaacactagc atttattcat tgggtttggg
     5881 ctagtaattt ctccatccct ctgctataat aaaaagaaat aaaaggatta gagaggttct
     5941 ttatttgaag gaacattcaa tagacattca actgagtcat ccagatgacc tgtttcatct
     6001 ttttggttcc aatgagcgcc atcttcgttt gatggaagaa gagctggatg tggtgattca
     6061 tgctcgtacg gagattgtcc aggttttggg agaagagtct gcttgtgagg aagcccgtca
     6121 ggttattcaa gctctcatgg tcttggtgaa ccgtgggatg accgttggta cgccagatgt
     6181 agtgacggct attagtatgg tcaaaaacga tgaaattgat aagtttgtcg ccctttacga
     6241 agaagaaatt atcaaggata atactgggaa accgatccgc gtcaaaacct taggtcaaaa
     6301 actttatgtg gacagtgtca aacagcatga tgtgaccttt ggaattgggc ctgcagggac
     6361 ggggaagacc tttcttgcag ttactttggc agtgactgcc cttaaacgtg ggcaagtcaa
     6421 gcggattatc ttgacacgtc cagcggtgga agcaggagag agtctaggtt ttcttccggg
     6481 tgatcttaag gagaaggtag atccttacct tcgtcctgtt tacgatgcct tgtatcagat
     6541 tctggggaaa gaccaaacga ctcgtctcat ggagcgtgaa attatcgaaa ttgcgcccct
     6601 tgcctatatg cgtggccgga ccttggatga tgcctttgtc attctcgatg aggcgcaaaa
     6661 cacgaccatc atgcagatga agatgttctt gacgcgttta ggctttcatt ctaagatgat
     6721 tgtcaatgga gatatcagtc agattgacct gccacgtaat gtcaagtccg gtttgattga
     6781 tgctcaagag aaactcaaga acatccatca gattgacttt gttcattttt cagccaagga
     6841 tgtggttcgc catccagttg tcgctcagat tatccgagcc tatgaatatt ctactgaagt
     6901 tgcacacgac tgattttgag gaagttcgcc tgcaaaagaa tatacttttg agagaggaaa
     6961 atccagttgt ataggctaaa ggttttatcc aaaggtctga gacaacgatt aggcacgatg
     7021 gaaagaactt ttatgtggct gatgacgatc agtgcatctt cctgtgtcat aatcacaggg
     7081 cacaagaaag taggaatttg aaaagatgat tgaccaacta tctaagtatt acagttgtag
     7141 gatactaact gaaaaggata ttccaagtat tttatcttta tatgaaagta atcctctgta
     7201 ttttcagcat tgtccaccag agccaaattt tgcaactgta aaagaggaca tgctttgtct
     7261 acctgaaggt aaagctaagg ctgataagtt ttttgttgga ttttggaatg gatctgacct
     7321 tgtggctgtt atggattttg tctatgcata tcctgatgag gagactgttt ttattggttt
     7381 gtttatggtt gatcaagcct atcagagaaa agggattggt agtcatattg tgacagaagc
     7441 actagcttat tttgctaaga actttcgaaa ggcacgtttg gcttatgtta agggaaatcc
     7501 gcaatctcag catttttggg aaaagcaggg ctttaaatca attggatgcg aggttaagca
     7561 agaactctat acggttgtta tcgctgaaca gagcctagaa gattagaaat ggcatcaagt
     7621 aagaactatt tggaatttgt tttggaacaa ttatcaggat tagatgatgt gacttaccgt
     7681 tccatgatgg gggagtatat tctttacttc cgcggcaaga ttattggcgg catttatgac
     7741 gatcgctttt tagttaaacc cgtgcaagca gtcttagata agattgacca atcttctttt
     7801 gagtttccat acaaaggtgc caaagaaatg atttgagtgg aagaacttga taataagatg
     7861 tttctataag acctgatttt agctatgtat aaccaactgc caacgcccaa acctaaaaag
     7921 aaaaagcaag ggtgaacgaa gtaaaaaaga agtctgctaa ggccctgtct ttgcacgggt
     7981 aaaattttat atataaaaag aagctgggac taaagagctc agcttccttt ggtttatata
     8041 attgtcatta caagacgaag tggttgggcg aaactctgtt gactttattc aatttagagt
     8101 ttcttatgca caattgagtc tggaacgaaa gtctccagtt gcaaagtata cagtacaata
     8161 aaccaacgat gtaatagctg atgacacaaa gcacagtggg taggacttgc gaagtcaccc
     8221 ttttcttttc aaaatttata ctaaatcatt gatatcagtg tagtcacgat taagtccttg
     8281 agcaactggt aggttagtca agtaaccttg ataagtagtc acaccttgac gcaagccttc
     8341 atcttcagag attgcttgtg cgaatccttt gccagccaaa gcttcgatat aaggaagagt
     8401 gacattggtt agggcgatgg ttgaagtgcg agcaaccgca ccagggatat tggcaacggc
     8461 atagtggaga acaccgtgtt tttcatagac gggttcatcg tgcgttgtca cacggtcagc
     8521 tgtttcgata acgccacctt ggtcaacagc aacgtcaacg atacagagcc tggacgcatt
     8581 tgtttgacca tctcatctgt caccaattcc ggtgcttttg caccagggat gagaatggct
     8641 ccaatcacca catcagcatc tctcacactt gcttcaatgt tgaatgaatt agacataaga
     8701 gtttgaattt gacttccaaa gacttcttct agaactgaga gacgcttggc actaatatct
     8761 aaaatagtca cttgagcacc aagaccaagg gcgatgcggg cagcatgtgt accgacgaca
     8821 ccatcaccga tgatagttac ttttcctttt ggaacacctg gtacaccacc aagtagaaca
     8881 ccagagccac cagcttgctt agtaaggaag tgagctccga tttaaacagc catacgacct
     8941 gcaacctcac tcataggaac gaggagcggt agttgtcctt gattgtcacg aacagtttca
     9001 taggcaattc ctgttgtttt tgctgctaac atagcatctg ctaattctgg agcagcggcc
     9061 atgtgcaagt aggtgaagag aagaagatcg tcgcgcaagt aaccgtattc agaacttaaa
     9121 ggttctttta ctttcacaac caactctgct gcccaagctt caccagcagt agcgacaatc
     9181 tcagctcctt gcttttgata gtcagcatca gtaaagccag aaccgagacc agcatttgtt
     9241 tcgataagga cacgatgacc acgactaact aagctatgaa cacctgcagg tgtgagggcg
     9301 acacggtttt cgttattttt aatttctttt gggattccga ttaacattga gataacctac
     9361 ctttcaattg acggtcttgt tttggttgtc acattccagt tcataaatca aaaatgtgac
     9421 ggtttcattg tatatgaaac cgcttcaaaa atcaagaaaa acttgtcatc ccaatttttt
     9481 tatgctagac tagtgaaaat caagctctaa tggagggaaa agtatggaat caatttttgt
     9541 aaaacttgcc cagtatccgt ctatagaaac ggagcgttta ttgcttagac ctgtaacttt
     9601 ggatgatgcg gaagcaatgt ttgactatgc ctcggacaag ggtaatacac gttacacttt
     9661 tccaaccaat caaagcttgg aagaaaccaa gaataacatt gctcagttct acttggctaa
     9721 tcccttggga cgttggggaa tagaactaaa aagcaatggc aaatttatcg gaacaattga
     9781 tttgcacaag attgatcctg ttcttaagaa ggtagctatt ggttatatta tcaaccaaac
     9841 gtattggaat caaggattaa cgacagaaac caatcgtgct gtgattgagc tagcttttga
     9901 gaagatagga atgaataagt tagttgcttt atacgataag gctaatcccg catcaggaaa
     9961 ggtcatggag aaatcaggaa tgcgtttttc ccatgcagaa ccatatgctt gtatggacca
    10021 gcatgaaaaa ggccgaatcg tgacaagagt tcattatgtc ttgaccaagg aagactattt
    10081 tgcaaataaa taagcagttg aaaagaaatt tttcgactgt tttttcttcc tcttacgaat
    10141 aatctaagag aggagaaaat atggaagcaa ttatcgagaa aatcaaagag tataaaatca
    10201 tcgtcatctg tactggtctg ggcttgcttg taggaggatt tttcctgcta aaaccagctc
    10261 cacaaacacc tgtcaaagag acgaatttgc aggctgaagt cgcagctgtt tccaaggatt
    10321 tggtatccga agaggaagtg aacaaggaag aaaaggaaga accccttgaa caagatctaa
    10381 tcacagtaga tgtcaaaggt gctgtcaaat cgccagggat ttatgacttg cctgtaggta
    10441 gtcgagtcaa tgatgctgtt cagaaggctg gtggcttgac agagcaagca gacagcaagt
    10501 cgctcaatct agctcagaaa gttagtgatg aggctctggt ttacgttcct actaagggag
    10561 aagaagcagt tagccaacag actggtttgg ggacagcttc ttcaataagc aaggaaaaga
    10621 aggtcaatct caacaaggcc agtctggaag aactcaagca ggtcaaggga ctgggaggaa
    10681 aacgagctca ggacattatc gaccatcgtg aggcaaatgg caagttcaag tcagtagacg
    10741 agctcaagaa ggtctctggc attggtggca aaacaataga aaagcttaaa gactatgtta
    10801 cagtggatta agaatttctc tattccccta atttacctga gttttctatt actttggctt
    10861 tattacgcta ttttctcagc atcttatctt gctttgttgg gctttgtttt tctgctagtc
    10921 tgtctcttta tccaatttcc gtggaaatct gctggtaaag ttctaataat ttgcggaatc
    10981 tttggatttt ggtttgtttt tcaaaattgg caacagagtc aagcgagtca aaatctggcg
    11041 gattctgttg aaagggtacg gattttacct gatactatta aggttaatgg tgatagtcta
    11101 tcctttcgtg gcaagtctaa cggtcgtgct ttccaagtct attataaact ccagtccgag
    11161 gaggagaaag aagcctttca agctttaacc gacctgcatg agataggact agaagggaag
    11221 ctttcggagc cagaagggca gagaaatttt ggtggcttta attaccaagc ctatctgaag
    11281 actcagggaa tttaccagac tctcaatatc aaaaaaatcc agtcacttca aaagattggc
    11341 agttgggata taggagaaaa cttgtccagt ttacgtcgaa aggctgtggt ttggattaag
    11401 acgcactttc cagaccctat gcgcaattac atgacaggac tcttgctggg acatctggac
    11461 accgactttg aggagatgag tgagctttat tccagtctag gaattatcca cctctttgcc
    11521 ctatctggca tgcaggtagg ttttttcatg aatggattta agaaacttct cttgcgattg
    11581 ggcttgaccc aagaaaagtt gaaatggctg acttatccct tttcccttat ctatgcggga
    11641 ctaactggat tttcagcatc ggttattcgc agtctcttgc aaaagctact ggctcaacat
    11701 ggggttaagg gcttggataa ttttgccttg acggtgcttg tcctctttat tgtcatgcca
    11761 aactttttct tgacagcagg aggagtcttg tcctgcgctt atgcttttat cctgaccatg
    11821 accagcaaag aagggaaggg gctcaaggct gttgctagtg aaagtctagt catctccttg
    11881 ggcatattgc ccattctatc cttctatttt gcggaatttc aaccttggtc tatccttttg
    11941 acctttgtct tttcctttct atttgacttg accttcttac cgctcttgtc tattttattt
    12001 gtcctttcct ttctctatcc agtcattcag ctgaacttta tctttgaatg gttggagggc
    12061 attattcgct tggtctcaca ggtgacaagt aggcctctag tctttggaca acccaacgca
    12121 tggcttttaa tcttattgtt aatttctttg gctttggtct atgatttgag gaaaaacatt
    12181 aaaggattaa cagtattgag tttattgatt acaggtctct ttttcttgac caagtatcca
    12241 ctggaaaatg aaatcaccat gctggatgtg gggcaaggag aaagtatttt cctacgggat
    12301 gtaactggga aaaccattct catagatgta ggtggtaagg cagaatctta taagaaaatc
    12361 gaaaaatggc aagaaaagat gacgaccagc aatgcccagc gaaccttgat tccctatctc
    12421 aaaagtcgag gagtagctaa gattgaccag ctaattttga ctaacacgga caaggagcat
    12481 gttggagatt tgtcagaggt gaccaaggct ttccatgtag gggagattct agtatcaaaa
    12541 gacagtctga aacagaagga atttgtggca gaactacagg tgactcaaac aaaggtgcgt
    12601 agtatgacag taggggagta cttgcccatt ttcggaagtc agttagaagt cctatctcca
    12661 agggaaattg gatatggagg tcatgaagat tccctggttc tttatgggaa actcttgaat
    12721 aatcactttc tcttcatagg aaatttggag gagaaaggag agaaggactt gctgaagtac
    12781 tatccagact tgaaagtaaa tgttttgaaa gctagccaac atggcaataa aaaatcatca
    12841 agtccagcct ttctagaaaa actcaaacca gagcttactc ttatctcagt tggaaagagc
    12901 aatcgaatga aactccccca tcaggaaaca ttgacacgac tggaaggtat caatagcaaa
    12961 gtttaccgaa ctgaccagca aggagctata cgctttaagg ggttggatag ttggaaaatc
    13021 gaaagtgttc gataggaagg ataaatgttg tagattagtg aaataaacta aaaatttgtt
    13081 gcataataat gataaaaatg gtataatgaa aacgtattca atattgagga tataaaatca
    13141 ttaaaaatta gcaaaaatcg tttaattagt tagtttatga ttattggtct ttttcagtcc
    13201 agtatatctg ctgtgacagt cactaaaagt tacaagtatg attggaatac ggtttgggaa
    13261 tatagtacca actatcacga ccatcagtat gcttggattc cgtcatggtc tcgttatgac
    13321 agctattctg agtatccagt tggttctggc tggaactacg gtcgttatga ggtcataaac
    13381 tattacagcg gaggctatta atccttaaag agtgagaaaa ggagggctgg atatgttaaa
    13441 tcttactcat gttaccttaa aaacgcgaca agtcatcttg caagatgcgg attttacctt
    13501 taaaaagggt aggatttatg gccttcttgc tatcaatggc tcgggaaaga cgaccctgtt
    13561 ccgtgccatt agcaatttaa ttcccataag tagtggaaat atcgcagccc ctccttcttt
    13621 attttattat gagagtattg aatggctgga tggaaactta agtgggatgg actaccttcg
    13681 tcttatcaaa aacatctgga agtcaggtct gaacttgagg gatgaaatcg cctattggga
    13741 aatgtctgat tatatcagcc ttcccattcg caagtattcc ttaggcatga agcaacgctt
    13801 ggtgattgcc atgtatttcc tcagtcaggc caaatgctgg ctcatggatg agattacaaa
    13861 tggcttagat gagtattatc gacagaagtt ttttgatagg ctagcacaaa tcgatagaca
    13921 agaacagctg gttcttttaa gttcccacta taaggaagag ttggttgatg tctgcgatag
    13981 agtagtaacc attcatcagg ggcagataga agaggtttag tttatgaaag atgttagtct
    14041 atttttattg aaaaaagttt tcaaaagtcg tttaaactgg attatcttac ttttatttgc
    14101 atctgtactc ggtgttacct tttatttaaa tagtcagact gcaaactcac acagcttgga
    14161 gagcaggttg gaaagtcgca ttgcagccaa cgagagggct atcaatgaaa atgaagagaa
    14221 actctcccaa atgtctgata ccagctcgga ggaataccag tttgctaaaa ataatttaga
    14281 cgtgcaaaaa aatcttttga cgcgaaagac agaaattcta actttactaa aagaagggcg
    14341 ctggaaagaa gcctactatc tgcagtggca agatgaagag aagaattatg aatttgtatc
    14401 aaatgacccg actgctatct ctggcttaaa aatgggggtt gaccgcgaac ggaagattta
    14461 ccaagccctg tatcccttga acataaaagc acatactttg gagtttccga cccacgggat
    14521 tgatcagatt gtctggattt tagaggttat catcccaagc ttgtttgtgg ttgcgattat
    14581 ttttatgcta acacaactat ttgcagaaag atatcaaaat catctggaca cagctcactt
    14641 atatcctgtt tcaaaagtga catttgcaat atcctctctt ggagttggag tgggatatgt
    14701 aactgtgctg tttatcggaa tctgtggctt ttcttttcta gtgggaagtc tgataagtgg
    14761 ttttggacag ttagattatc cctacccaat ttatagctta gtgaatcaag aagtaactat
    14821 tgggaaaata caagatgtat tatttcctgg cttgctctta gctttcttag cctttatcgt
    14881 cattgtggaa gttgtgtact tgattgctta ctttttcaag caaaaaatgc ctgtcctctt
    14941 tctttcactc attgggattg ttggcttatt gtttggcatc caaacaattc agcctcttca
    15001 aaggattgca catctgattc cctttactta cttgcgttca gtggagattt tatctggaag
    15061 attatctaag cagattgata atgtcgatct aaattggagc atggggatgg tcttacttcc
    15121 ttgcctgatt atctttttgc tagtggggat tctatttatc gaaaactggg gaagttcacg
    15181 taaaaaggaa gtttttaata ggtcttagca ttcttataag gaagttaagg aaaaactaac
    15241 atagagaggg aatcaacttg attctctctt tttaattcga aaaccaaaat acaaacacaa
    15301 acttttcaaa aaataacttt ttatcttgac aagagctaga aaacttggta tcatataaaa
    15361 gttgagaaaa gcagaagtga gagcttctcg ccttgtgaca ttaagttgcc tggccctacg
    15421 gatgaaaagt ttcgaagaaa cgctatcata acgtgcgggc ttgtatattt acgagtccgc
    15481 tattgttttt ctctaataaa acaaaagagg tgaaaaccat agcaaagcaa gacttattca
    15541 tcaatgatga gattcgtgta cgtgaagttc gcttgattgg tcttgaagga gaacagctag
    15601 gcatcaagcc actcagtgaa gcgcaagctt tggctgataa cgctaatgtt gacctagtat
    15661 tgattcaacc ccaagccaaa ccgcctgttg caaaaattat ggactacggt aagttcaaat
    15721 ttgagtacca gaagaagcaa aaagaacaac gtaaaaaaca aagcgttgtt actgtgaaag
    15781 aagttcgtct aagtccaaca attgacaagg gtgactttga tacaaaactt cgtaatgcac
    15841 gtaagttcct tgaaaaagga aataaagtta aggtatctat tcgctttaag ggtcgtatga
    15901 ttacccataa agagattggt gcaaaagttt tagccgagtt tgctgaagca actcaagata
    15961 ttgccatcat cgaacaacgt gctaaaatgg atggacgtca aatgttcatg caattggcgc
    16021 cagcgactga caaaaaataa ttgtcagaaa gttaaataaa ggagaaaaaa tcatgccaaa
    16081 acaaaaaaca caccgcgcat cagctaaacg tttcaaacgt acaggttctg gtggacttaa
    16141 acgtttccgt gcttacactt ctcaccgttt ccacggaaaa actaagaaac aacgtcgtca
    16201 tcttcgtaaa gcatctatgg tgcattcagg agattacaaa cgtatcaaag caatgcttac
    16261 tcgcttgaaa taatagcttg actgtaagta aacaattcta ggaaatattt ggaggaaata
    16321 aaacatggca cgtgttaaag gtggcgttgt atcacgcaaa cgtcgtaaac gtattcttaa
    16381 attagcaaaa ggttactatg gagctaaaca catcttgttc cgtactgcaa aagaacaagt
    16441 aatgaactct tactactatg cataccgtga ccgtcgtcag aaaaaacgtg acttccgcaa
    16501 attgtggatt actcgtatca atgcggcagc tcgtatgaac ggactttcat actcacaatt
    16561 gatgcatggt ttgaaattgg ctgagatcga agttaaccgt aaaatgcttg ctgacttggc
    16621 tgttaacgat gcagtagctt tcacagctct tgcagatgca gctaaagcaa aacttggtaa
    16681 ataacaactg atgagactgg aacaggattg tccagtcttt ttaaaaataa aggagaaaga
    16741 tatggcttca aaaatgctac acacttgctt acgagtagaa aatcttgaaa aatcaatcgc
    16801 attttatcaa gatgcttttg gttttaaaga attgcgtcgc agagattttc cagaccatgc
    16861 cttcacgatt gtctatctag gtcttgaggg tgatgattat gagttggagt tgacttataa
    16921 ctacgatcac ggtccgtatg tggttggtga tgggtttgcc catatcgccc tcagtacacc
    16981 tgatcttgag gcacttcatc aagaacacag tgcaaaaggc tatgaagtga ctgagccaaa
    17041 tggtctacca ggaactacac caaactatta ctttgttaaa gaccctgatg gatataaggt
    17101 cgaagtcatt cgtgaaaaat aatttcgtgc aagttaagta gaatattcgt tttctacttg
    17161 acttttttta gctgaaagag tatactaata aaaattcaac ctttaagggg agtccagaga
    17221 gactcacaag gtgtcagata aaagaatagt gcaattttct agaggagacc ttttgagtgt
    17281 gctctcttgt gttgtacgat tttaactgag gccttgcact agcaaggtct tttctttatc
    17341 tggtcccctt aaaatttaag gaggaaaagt tatgaatctc acatgtaaga agcgtttggg
    17401 tgtcattcgg ttggaaacca tgaaggtggt tgcacaagag gaaatcgcgc cagcaatctt
    17461 tgaattagtc ctagaaggag aaatggttga agccatgcga gcaggccaat ttcttcatct
    17521 gcgtgtacca gacgatgccc atctcttacg tcgtcctatt tcaatttcgt ctattgacaa
    17581 ggcaaacaag cagtgtcacc tcatttatcg gattgaggga gctgggactg caattttttc
    17641 aaccttaagt cagggagaca ctcttgatgt gatggggcct cagggaaatg gttttgactt
    17701 gtctgacctt gatgagcaga atcaggttct ccttgttggt ggtgggattg gtgttccacc
    17761 cttgcttgag gtggccaagg aattgcatga acgtggagtg aaagtagtga cagtcctcgg
    17821 ttttgctaat aaggatgctg ttattttgaa aacggaattg gctcagtatg gtcaggtctt
    17881 tgtaacgaca gatgatggtt cttatggcat caagggaaat gtttccgttg ttatcaatga
    17941 tttagatagt cagtttgatg ctgtttactc gtgtggggct ccaggaatga tgaagtatat
    18001 caatcaaacc tttgatgatc acccaagagc ctatttatct ctggaatctc gtatggcttg
    18061 tgggatggga gcttgctatg cctgtgttct aaaagtacca gaaagcgaga cggtcagcca
    18121 acgcgtctgt gaagatggtc ctgttttccg cacaggaaca gttgtattat aaggagaaaa
    18181 ttatgactac aaatcgatta caagtgtccc tacctggttt ggatttgaaa aatccgatta
    18241 ttccagcatc aggctgtttt ggctttggac aagagtatgc caagtactat gatttaaacc
    18301 ttttaggttc tattatgatc aaggcgacaa cccttgaacc acgttttggg aacccaactc
    18361 caagagtagc agagacgcct gctggtatgc tcaatgcaat tggcttgcaa aatcctggtt
    18421 tagaggttgt tttggctgaa aagttacctt ggctggaaag agaatatcca aatcttccta
    18481 ttattgccaa tgtagctggt ttttcaaaac aagagtatgc agctgtttct catgggattt
    18541 ccaaggcaac taatgtaaaa gctatcgagc tcaatatttc ttgtcccaat gttgaccact
    18601 gtaatcatgg acttttgatt ggtcaagatc cagatttggc ttatgatgtg gtgaaagcag
    18661 ctgtggaagc ctcagaagtg ccagtttatg tcaaattaac cccgagtgtg accgatatcg
    18721 ttactgtcgc aaaagctgca gaagatgcgg gagcaagtgg cttgaccatg atcaatactc
    18781 tggttggaat gcgctttgac ctcaaaacca gaaaaccaat cttggccaat ggaacaggtg
    18841 gaatgtcagg tccagcagtc tttccagtag ccctcaaact catccgccaa gtagcccaaa
    18901 caacagacct gcctatcatt ggaatggggg gagtggattc ggctgaagct gccctagaaa
    18961 tgtatctggc tggggcatct gctatcggag ttggaacagc taactttacc aatccttatg
    19021 cctgccctga catcatcgaa aatttaccaa aagtcatgga taaatacggt attagcagtc
    19081 tggaagaact ccgtcaggaa gtaaaagagt ctctgaggta aactacaatc aatctgttct
    19141 tgatttttta ttagtttgta atatgaattt aggagaattt tggtacaata aaataaataa
    19201 gaacagagga agaaggttaa tgaagaaagt aagatttatt tttttagctc tgctattttt
    19261 cttagctagt ccagagggtg caatggctag tgatggtact tggcaaggaa aacagtatct
    19321 gaaagaagat ggcagtcaag cagcgaatga gtgggttttt gatactcatt atcaatcttg
    19381 gttctatata aaagcagatg ctaactatgc tgaaaatgaa tggctaaagc aaggtgacga
    19441 ctattttcac ctcaaatctg gtggctatat ggccaaatca gaatgggtag aagacaaggg
    19501 agccttttat tatcttgacc aagatggaaa gatgaaaaga aatgcttggg taggaacttc
    19561 ctatgttggt gcaacaggtg ccaaagtaat agaagactgg gtctatgatt ctcaatacga
    19621 tgcttggttt tatatcaaag cagatggaca gcacgcagag aaagaatggc tccaaattaa
    19681 agggaaggac tattatttca aatccggtgg ttatctactg acaagtcagt ggattaatca
    19741 agcttatgtg aatgctagtg gtgccaaagt acagcaaggt tggctttttg acaaacaata
    19801 ccaatcttgg ttttacatca aagaaaatgg aaactatgct gataaagaat ggattttcga
    19861 gaatggtcac tattattatc taaaatccgg tggctacatg gcagccaatg aatggatttg
    19921 ggataaggaa tcttggtttt atctcaaatt tgatgggaaa atagctgaaa aagaatgggt
    19981 ctacgattct catagtcaag cttggtacta cttcaaatcc ggtggctaca tggcagccaa
    20041 tgaatggatt tgggataagg aatcttggtt ttacctcaag tttgatggca aaatggctga
    20101 aaaagaatgg gtctacgatt ctcatagtca agcctggtac tacttcaaat ccggtggtta
    20161 catgacagcc aatgaatgga tttgggataa ggaatcttgg ttttatctca aatctgatgg
    20221 gaaaatagct gaaaaagaat gggtctacga ttctcatagt caagcttggt actacttcaa
    20281 atccggtggt tacatgacag ccaatgaatg gatttgggat aaggaatctt ggttttacct
    20341 caagtctgat ggcaaaatgg ctgaaaaaga atgggtctac gattctcata gtcaagcctg
    20401 gtactacttc aaatctggtg gctacatggc gaaaaatgag acagtagatg gttatcagct
    20461 tggaagcgat ggtaaatggc ttggaggaaa agctacaaat gaaaatgctg cttactatca
    20521 agtagtgcct gttacagcca atgtttatga ttcagatggt gaaaagcttt cctatatatc
    20581 gcaaggtagt gtcgtatggc tagataagga tagaaaaagt gatgacaagc gcttggctat
    20641 tactatttct ggtttgtcag gctatatgaa aacagaagat ttacaagcgc tagatgctag
    20701 taaggacttt atcccttatt atgagagtga tggccaccgt ttttatcact atgtggctca
    20761 gaatgctagt atcccagtag cttctcatct ttctgatatg gaagtaggca agaaatatta
    20821 ttcggcagat ggcctgcatt ttgatggttt taagcttgag aatcccttcc ttttcaaaga
    20881 tttaacagag gctacaaact acagtgctga agaattggat aaggtattta gtttgctaaa
    20941 cattaacaat agccttttgg agaacaaggg cgctactttt aaggaagccg aagaacatta
    21001 ccatatcaat gccctttatc tccttgccca tagtgcccta gaaagtaact ggggaagaag
    21061 taaaattgcc aaagataaga ataatttctt tggcattaca gcctatgata cgacccctta
    21121 cctttctgcc aagacatttg atgatgtgga taagggaatt ttaggtgcaa ccaagtggat
    21181 taaggaaaat tatatcgata ggggaagaac tttccttgga aacaaggctt ctggtatgaa
    21241 tgtggaatat gcttcagacc cttattgggg cgaaaaaatt gctagtgtga tgatgaaaat
    21301 caatgagaag ctaggtggca aagattagta ctataagtga atatgatttg agtgaatagt
    21361 aagttaaaaa tcctgatttc aagtaaaatc aggatttttt catggatgca atttttttgg
    21421 agtctggtgt gacgcggagg gtcttttgtc ctgtgtaagt gacaaagccg ggttttccac
    21481 cagttggttt attgagtttt ttgacttcaa tcatatctac ctgcaccaga ttcgacaggc
    21541 gcccttgaga gaagtaggca gctaactctg ctgcgtctgt cttgactgca tcagatgggt
    21601 caagatttcc tgagatgaca acatggcttc caggaatgtc cttagcatgg aaccaaagtt
    21661 cctccttgcg ggccatttta aaggtcaatt cctcattttg aagattgttt cgtccgacat
    21721 agatgatggt tttgccatcg cttgctagat attgttctag ttttttgcgt ttctggattt
    21781 tctcccgttg tcttctgcgg ataaaacctg tttgaatcaa ttcttcacgg atttcagcga
    21841 tttcttccag tccagcttgg ttgaggacgg tttctacact ttccagatag agaatagtgg
    21901 ctttggtttc ttcaatcaaa tcagtcaagt atttgacagc ttctttgagt ttctgatacc
    21961 gtttaaaata gcgttgggca ttctggttgg gagtcagagc cttatcaagc gcaatcatga
    22021 taggttggtt ggtatagtag ttgtctagga taacctggtc ttggtcgtta ggcacttggt
    22081 gtaggaaggt tgtcagcaat tctccttttt gacgaaattc ttcagcgttg tctgtcgcca
    22141 gtaactcttt ttcctgtttt ttgagtttgt gtcggttttt ctgaagttca ttttcaacac
    22201 gacgaatcag ttcactggcc tgctgtttga cgcggtcgcg ctcagcctta tccttatagt
    22261 aggtgtccaa caaatcagaa agatttgcaa aaggctctcc cacctgattt gcaaaaggaa
    22321 ctggactgaa ggaagtctca gtcaagcatg gcttggtttc ttgattgaaa aaatttcgga
    22381 aagcggaaag tttttcacta accagtatcc tttccaattc atttgccgta tcgcgtccca
    22441 gaccttgaaa gaggctttga agattttttg ctgttagttc ttgggtttgc aggatttcaa
    22501 agagcttttc atccttgata gtaaaaggat tgagagattc tgtacttggc ggagcgatat
    22561 aggtcgatcc tggaagtaag gtgcggtagc tattttgtga aaaaccgacg tgtttgataa
    22621 cttcgaggat tttatgactg cttttatcga ccagtagaat attactgtgt ttccccataa
    22681 tttcaataat caaggtagcc tggatatggt ctccaatctc gtttttattg gaaactgtca
    22741 tttccacaat acggtcattt tccacttgct caatcgactc aatcagggcc ccctgcaaat
    22801 actttctcaa aaccatgata aaggtagaag gttgagctgg attttcaaaa gtcgtttggg
    22861 tcagctgaat gcgtccaaaa actggatggg cagaaaggag caggcgatgg ctttggcgat
    22921 tgctgcggat ttgcaagacc aactcttgtt caaaaggctg attgattttc tggatgcgac
    22981 cattcactaa ttcgcttcgc aattcctcaa ctatgtggtg taaaaaaaat ccatcaaatg
    23041 acatcgttct ctccttgtga ttgtattcca tagtattata tcaaaaaggt agaataaaat
    23101 catggaaatg tggtataata aagccaagta aagagaaatg agaagcacat gtatattgaa
    23161 atggtagatg aaactggtca agtttcaaaa gaaatgttgc aacaaaccca agaaattttg
    23221 gaatttgcag cccaaaaatt aggaaaagaa gacaaggaga tggcagtcac ttttgtgacc
    23281 aatgagcgta gtcatgaact taatctggag taccgtgaca ccgaccgtcc gacagatgtc
    23341 atcagccttg agtataaacc agaattggaa attgcctttg acgaagagga tttgcttgaa
    23401 aatccagaat tggcagagat gatgtctgag tttgatgcct atattgggga attgttcatc
    23461 tctatcgata aggctcatga gcaggccgaa gaatatggtc acagctttga gcgtgagatg
    23521 ggcttcttgg cagtacacgg ctttttacat attaacggct atgatcacta cactccggaa
    23581 gaagaagcgg agatgttcgg tttacaagaa gaaattttga cagcctatgg actcacaaga
    23641 caataaacga aaatggaaaa atcgtgacct gatatccagt ttagaatttg ccatcacagg
    23701 gatttttact gctatcaagg aagaacgaaa tatgcgaaaa catgcagtga cggctctagt
    23761 ggtcatcctt gcaggttttg tttttcaggt gtcacgaatc gaatggctct ttctcctatt
    23821 gagcattttc ttggtagtag cctttgagat tatcaattct gctatcgaaa atgtggtgga
    23881 tttggccagt cactatcact tttccatgct ggctaaaaat gccaaggata tggcggctgg
    23941 cgcggtatta gtggtttctc ttttcgcagc cttaacaggt gcattgattt ttctcccacg
    24001 aatctgggat ttattatttt aaacagtaag aggaaattat gacttttaaa tcaggctttg
    24061 tagccatttt aggacgtccc aatgttggga agtcaacctt tttaaatcac gttatggggc
    24121 aaaagattgc catcatgagt gacaaggcgc agacaacgcg caataaaatc atgggaattt
    24181 acacgactga taaggagcaa attgtcttta tcgacacacc agggattcac aaacctaaaa
    24241 cagctctcgg agatttcatg gttgagtctg cctacagtac ccttcgcgaa gtggacaccg
    24301 ttcttttcat ggtgcctgct gatgaagcgc gtggtaaggg ggacgatatg attatcgagc
    24361 gtctcaaggc tgccaaggtt cctgtgattt tggtggtgaa taaaatcgat aaggtccatc
    24421 cagaccagct cttgtctcag attgatgact tccgtaatca aatggacttt aaggaaattg
    24481 ttccaatctc agcccttcag ggaaataacg tgtctcgtct agtggatatt ttgagtgaaa
    24541 atctggatga aggtttccaa tatttcccgt ctgatcaaat cacagaccat ccagaacgtt
    24601 tcttagtttc agaaatggtt cgcgagaaag tattgcacct aactcgtgaa gagattccgc
    24661 attctgtagc agtagttgtt gactctatga aacgagacga agagacagac aaggttcaca
    24721 tccgtgcaac catcatggtc gagcgcgata gccaaaaagg gattatcatc ggtaaaggtg
    24781 gcgctatgct taagaaaatc ggtagcatgg cccgtcgtga tatcgaactc atgctaggag
    24841 acaaggtctt cctagaaacc tgggtcaagg tcaagaaaaa ctggcgcgat aaaaagctag
    24901 atttggctga ctttggctat aatgaaagag aatactaagt agaggtaggc tcatgcctgc
    24961 ttcttgtttt tacagaagga ggacttatgc ctgaattacc tgaggttgaa accgtttgtc
    25021 gtggcttaga aaaattgatt ataggaaaga agatttcgag tatagaaatt cgctacccca
    25081 agatgattaa gacggatttg gaagagtttc aaagggaatt gcctagtcag attatcgagt
    25141 caatgggacg tcgtggaaaa tatttgcttt tttatctgac agacaaggtc ttgatttccc
    25201 atttgcggat ggagggcaag tatttttact atccagacca aggacctgaa cgcaagcatg
    25261 cccatgtttt ctttcatttt gaagatggtg gcacgcttgt ttatgaggat gttcgcaagt
    25321 ttggaaccat ggaactcttg gtgcctgacc ttttagacgc ctactttatt tctaaaaaat
    25381 taggtcctga accaagcgaa caagactttg atttacaggt ctttcaagct gcccttgcca
    25441 agtccaaaaa gcctatcaaa tcccatctcc tagaccagac cttggtagct ggacttggca
    25501 atatctatgt ggatgaggtt ctctggcgag ctcaggttca tccagctaga ccttcccaga
    25561 gtttgacagc agaagaagcg actgccattc atgaccagac cattgctgtt ttgggccagg
    25621 ctgttgaaaa aggcggttcc accattcgga cctataccaa tgcctttggg gaagatggaa
    25681 gcatgcagga ttttcatcag gtctatgata agactggtca agaatgtgta cgctgtggta
    25741 ccatcattga gaaaattcaa ctaggcggac gaggcaccca cttttgtcca aactgtcaaa
    25801 ggagggactg atgagaaaaa tcatcggaat cactggggga attgcctctg gtaagtcaac
    25861 tgtgacaaat tttctaagac agcaaggctt tcaagtagtg gatgccgacg cagtcgtcca
    25921 ccaactacag aaacctggtg gtcgtctgtt tgaggctcta gtacagcact ttgggcaaga
    25981 aatcattctt gaaaacggag aactcaatcg ccctctccta gctagtctca tcttttcaaa
    26041 tcctgaagag caaaaatggt ctaagcaaat tcaaggggag attatccgtg aggaactggc
    26101 tactttgaga gaacagttgg ctcagacaga agagattttc ttcatggata ttcccctact
    26161 ttttgagcag gactacagcg attggtttgc tgagacttgg ttggtctatg tggaccgaga
    26221 tgcccaagta gaacgcttaa tgaaaaggga ccagttgtcc aaagatgaag ctgagtctcg
    26281 tctggcagcc cagtggcctt tagaaaaaaa gaaagatttg gccagccagg ttcttgataa
    26341 taatggcaat cagaaccagc ttcttaatca agtgcatatc cttcttgagg gaggtaggca
    26401 agatgacaga gattaactgg aaggataatc tgcgcattgc ctggtttggt aattttctga
    26461 caggagccag tatttctttg gttgtacctt ttatgcccat cttcgtggaa aatctaggtg
    26521 tagggagtga gcaagtcgct ttttatgcag gcttagcaat ttctgtctct gctatttccg
    26581 cggcgctctt ttctcctatt tggggtattc ttgctgacaa atacggccga aaacccatga
    26641 tgattcgggc aggtcttgct atgactatca ctatgggagg cttggccttt gtcccaaata
    26701 tctattggtt aatctttctt cgtttactaa acggtgtatt tgcaggtttt gttcctaatg
    26761 caacggcact gatagccagt caggttccaa aggagaaatc aggctctgcc ttaggtactt
    26821 tgtctacagg cgtagttgca ggtactctaa ctggtccctt tattggtggc tttatcgcag
    26881 aattatttgg cattcgtaca gttttcttac tggttggtag ttttctattt ttagctgcta
    26941 ttttgactat ttgctttatc aaggaagatt ttcaaccagt agccaaggaa aaggctattc
    27001 caacaaagga attgtttact tcagttaaat atccctatct tttgctcaat ctctttttaa
    27061 ccagttttgt catccaattt tcagctcaat cgattggccc tattttggct ctttatgtac
    27121 gcgacttagg gcagacagag aatcttcttt ttgtctctgg tttgattgtg tccagtatgg
    27181 gcttttccag catgatgagt gcaggagtca tgggcaagct aggtgacaag gtgggcaatc
    27241 atcgtctctt ggttgtcgcc cagttttatt cagtcatcat ctatctcctc tgtgccaatg
    27301 cctctagccc ccttcaacta ggactctatc gtttcctctt tggattggga accggtgcct
    27361 tgattcccgg ggttaatgcc ctactcagca aaatgactcc caaagccggc atttcgaggg
    27421 tctttgcctt caatcaggta ttcttttatc tgggaggtgt tgttggtccc atggcaggtt
    27481 ctgcagtagc aggtcaattt ggctactatg ctgtctttta tgcgacaagc ctttgtgttg
    27541 cctttagttg tctctttaac ctgattcaat ttcgaacatt attaaaagta aaggaaatct
    27601 agtgcgagta aaaattaatc tcaaatgctc ctcttgtggc agtatcaatt acctaaccag
    27661 taaaaattca aaaacccatc cagacaagat tgaggtttta aagtattgtc ccaaggaaag
    27721 aaaagtaacc ctacatcttg aatctaagta gattttatgg taaaataata gggattttaa
    27781 ggagtttgat atgtataacc tattattaac cattttatta gtattatctg ttgtgattgt
    27841 gattgcaatt ttcatgcaac caaccaaaaa ccaatccagc aatgtatttg atgccagttc
    27901 aggtgatttg tttgaacgca gtaaagctcg cggttttgaa gctgtaatgc agcgtttgac
    27961 agggatttta gtctttttct ggctagccat tgccttagca ttgacggtat tatcaagtag
    28021 ataagaaaat aatgggcagg actaggtctt tgcctctttt tatttttaaa ggatgtttga
    28081 gaaggtttta cagtaaaaga aaattaaaaa atctagaaag aaaatatgaa agatagaata
    28141 aaagaatatt tacaagacaa gggaaaggtg actgttaatg atttggctca ggctttggga
    28201 aaagacagtt ccaaggattt tcgtgagttg attaaaacct tgtccttaat ggaaagaaag
    28261 caccagattc gctttgaaga agatggcagt ctgaccttgg aagccaagaa aaaacatgag
    28321 attaccctca aggggatttt tcatgcccat aaaaatggtt ttggctttgt cagcctagaa
    28381 ggggaagagg acgacctttt tgtagggaaa aatgatgtca actatgctat tgatggtgat
    28441 accgttgagg tcgtcatcaa gaaagtcgct gaccgcaata agggaacagc agcagaagcc
    28501 aaaattattg atatcctaga acacagttta acaacagttg tcgggcaaat cgttctggat
    28561 cagggaaagc ctaagtatgt tggctatatt cgttcaaaaa atcagaaaat tagtcaaccg
    28621 atttatgtta agaaaccagc cctaaaatta gaaggaacag aagttctcaa agtctttatc
    28681 gataaatatc caagcaagaa acatgatttc tttgtcgcga gtgttctcga tgtggtggga
    28741 cactcaacgg atgtcggaat tgatgttctt gaggtcttgg aatcaatgga cattgtatcc
    28801 gagtttccag aagctgttgt taaggaagca gaaagtgtgc ctgatgctcc gtctcaaaag
    28861 gatatggaag gccgtctgga tctaagagat gaaattacct ttaccattga cggtgcggat
    28921 gccaaggact tggacgatgc agtgcatatc aaggctctga aaaatggcaa tttggagctt
    28981 ggggttcaca tcgcagatgt ttcttattat gtgaccgagg tgtctgccct tgacaaggaa
    29041 gcccttaacc gtgcgacttc tgtttacgtg acagaccgag tggtgccaat gcttccagaa
    29101 cgactatcaa atggcatctg ctctctcaat ccccaagttg accgcctgac ccagtctgct
    29161 attatggaga ttgataaaca tggtcgtgtg gtcaactata ccattacaca aacagttatc
    29221 aagaccagtt ttcgtatgac ctatagcgat gtcaatgata tcctagctgg cgatgaagaa
    29281 aagagaaaag aatatcataa aattgtatca agtatcgaac tcatggccaa gcttcatgaa
    29341 actttagaaa acatgcgtgt gaaacgtgga gctctcaatt ttgataccaa tgaagcgaag
    29401 attttagtgg ataaacaagg taagcctgtt gatatcgttc ttcggcagcg tggcattgcc
    29461 gagcggatga ttgagtcttt tatgttgatg gctaatgaaa cagttgccga acatttcagc
    29521 aagttggatt tgccttttat ctatcgaatt cacgaggagc ctaaggctga aaaggttcag
    29581 aagtttattg attatgcttc gagttttggc ttgcgtattt atgggactgc cagtgagatt
    29641 agtcaggagg cacttcaaga catcatgcgt gctgttgagg gagaacctta tgcagatgta
    29701 ttgtccatga tgcttcttcg ctctatgcag caggctcgtt attcggagca caatcacggc
    29761 cactatggac tagctgctga ctattatact cactttacca gtccaattcg tcgttatcca
    29821 gaccttcttg ttcaccgtat gattcgggat tacggccgtt ctaaggaaat agcagagcat
    29881 tttgaacaag tgattccaga gattgcgacc cagtcttcca accgtgaacg tcgtgccata
    29941 gaagctgagc gtgaagtcga agccatgaaa aaggctgagt atatggaaga atacgtgggt
    30001 gaagagtatg atgcagttgt atcaagtatt gtcaaattcg gtctctttgt cgaattgcca
    30061 aacacagttg aaggcttgat tcacatcact aatctacctg aattttatca tttcaatgag
    30121 cgtgatttga ctcttcgtgg agaaaaatca ggtatcactt tccgagtggg tcagcagatc
    30181 cgtatccgtg ttgaaagagc ggataaaatg actggagaga ttgatttttc attcgtacct
    30241 agtgagtttg atgtgattga aaaaggcttg aaacagtcta gtcgtagtgg cagagggcgt
    30301 ggttcaaatc gtcgttcgga taagaaggaa gacaagagaa aatcaggacg ctcaaatgat
    30361 aagcgtaagc attcacaaaa agacaagaag aaaaaaggaa agaaaccttt ttacaaggaa
    30421 gtagctaaga aaggagccaa gcatggcaaa gggcgaggga aaggtcgtcg cacaaaataa
    30481 aaaggcacgc cacgactata caatcgtaga tacgctagag gcagggatgg tcctgactgg
    30541 aactgaaatc aagagtgtac gagctgctcg aattaatctc aaggatggct ttgctcaagt
    30601 gaaaaatgga gaagtttggc tgagcaatgt tcatatcgcg ccttacgaag agggcaatat
    30661 ctggaaccag gaaccagaac gtcgtcgtaa actcctgctc tataaaaagc aaattcaaaa
    30721 attggaacaa gagaccaaag ggacaggaat gaccttagtt ccccttaagg tctatataaa
    30781 agatggctac gctaagcttc ttttaggact tgccaaaggg aagcatgact atgacaaacg
    30841 ggagtctatc aaacgtcgtg agcaaaatcg agatatcgcg cgtgtgatga aagctgttaa
    30901 tcagcgataa aaagaggaat tgaaaatgga aaaattagtt gcctataagc gcatgccttt
    30961 gtggaataaa caaacaatgc ctgaagctgt tcagcaaaag cacaatacaa aagttgggac
    31021 ttgggggaaa attactgtct tgaagggagc tatcaagttt attgaattga cagaagaagg
    31081 ggaagttcta gctgaacacc tctttgaagc aggggcagac aatccaatgg cccaacctca
    31141 agcctggcac cgagtggaag ctgccacaga tgatgtggaa tggtacttgg aattttattg
    31201 taaacctgag gattattttg ctaaaaaata caataccaat cctgttcatt cagaggtcct
    31261 agaggccatg cagacagtga aacaagggaa agctttggat ttgggttgtg gtcaggggcg
    31321 taattctctt tttctagccc agcaagattt tgatgtgacg gctgtagatc aaaatggact
    31381 agctcttgaa atcttgcaaa gcattgtgga gcaggaagat ttggacatgc ctgttggcct
    31441 ttacgatatc aattcagcta gcattgaaca agaatatgat tttatcgttt caacagttgt
    31501 tctcatgttt ctacaagcgg accgcattcc agctattatt caaaatatgc aggagaaaac
    31561 cagtgttggt ggttacaacc ttatcgtttg tgccatggac acggaggatt atccttgctc
    31621 ggttaacttc ccattcacct ttaaagaagg agaactggca gactattaca aggattggga
    31681 attggttaag tacaatgaaa atccaggcca tttgcatcgt cgcgatgaga atggcaatcg
    31741 tattcaacta cgctttgcga ccttactagc taagaaaatc aagtaaacac acatgaagat
    31801 taggaatttt cctgatcttt tttctttttt acgaatgata tagaaaagga gggaattcat
    31861 gtttgttgcg agagatgcta ggggagaatt ggtaaatgtg ttagaggata aacttgagaa
    31921 gcaagcatac acctgcccag cttgtggagg ccagctccat ttgcgtcaag gaccaagtgt
    31981 acggacgcat tttgcccata aatccttaaa agactgtgat tttttctttg aaaatgaaag
    32041 tccagaacac ctggccaata aggaatccct ctatcactgg ttgaaaaaag agacaaaggt
    32101 tcaattagag tacccgcttt cagaacttaa acagattgcg gatgtatttg taaatggcaa
    32161 tctagatcta gaagttcagt gtagtccctt gcctcagaaa gtccttaaag agcgaagtga
    32221 gggatatcgt agtcagggtt accaagtact gtggttgctg ggtcaaaaac tgtggctcaa
    32281 ggagcgtttg actcgtctac agcaaggttt tctttatttc agtcaaaaca tgggctttta
    32341 tgtttgggaa ttagacaagg aaaaacaagt tttaagactc aaatacctga tttaccagga
    32401 tctccgcggt aaactccatt atcaaatcaa ggaattttcc tatggtcaag gtagtttatt
    32461 ggaaatattg cgtcttccct ataagagaca aaaaatatct cattttacag tttctgagga
    32521 caaggacatc tgtcgctata tccggcaaca actttattat caaaatctct tttggatgaa
    32581 agaacaagca gaagcctatc aaaagggaga aaatatcctg acttatggac tgaaagaatg
    32641 gtatccacaa attcgaccaa tagtgggcaa atttttccag attgaacaag acttgactaa
    32701 ctattatcag cacttttata cctattacca aaaaaatcct caaaatgatt ggcaaaagct
    32761 ttatccacca gccttttatc agcaatattt cttgaaaaat atggtaaaat agaaaggatg
    32821 gaggaatcta atggtattac aaagaaatga aataaatgaa aaagatacat gggatctatc
    32881 aacgatctac ccaactgacc aggcttggga agaagcctta aaagatttaa cagaacaatt
    32941 ggagacagta gcccagtatg aaggccatct cttggatagt gcggataacc tactagaaat
    33001 cactgaattt tctcttgaaa tggaacgcca gatggagaag ctttacgttt atgctcatat
    33061 gaagaatgac caggatacac gtgaagctaa gtatcaagag tactatgcca aggccatgac
    33121 attctacagc cagttagacc aagccttttc attctatgag cctgaattta tggagattag
    33181 cgaaaagcag tatgctgact ttttagaagc tcaaccaaag ctgcaggttt atcaacacta
    33241 ttttgacaag ctcttgcaag gcaaggatca cgttctctca caacgtgaag aagaattatt
    33301 ggctggagct ggagaaatct ttggttcagc aagtgaaacc ttcgctatct tggacaatgc
    33361 ggatattgtg ttcccttatg tcctagacga tgatggtaaa gaagttcagc tatctcatgg
    33421 gatttacaca cgtttgatgg agtctaaaaa acgtgaggtt cgccgtggtg cctatcaagc
    33481 tctttatgcg acttacgaac aattccaaca cacctatgcc aaaaccttgc aaaccaatgt
    33541 taaggtgcaa aattaccgtg ctaaagttcg taactacaag agtgctcgtc atgcagccct
    33601 cgcagcgaat tttgttccag aaagtgttta tgacaatttg gtagcagcag ttcgcaagca
    33661 tttgccactc ttacatcgct atcttgagct tcgttcaaaa atcttgggga tttcagatct
    33721 caagatgtac gatgtctaca caccgctttc atctgttgaa tacagtttta cctaccaaga
    33781 agccttgaaa aaagcagaag atgctttggt agtcttgggt gaggattact tgagccgtgt
    33841 taaacgtgcc ttcagcgagc gttggattga tgtttacgaa aatcaaggca agcgttcagg
    33901 tgcctactct ggtggttctt acgataccaa tgcctttatg cttctcaact ggcaggacaa
    33961 tctggacaat ctctttactc ttgttcatga aacaggtcac agtatgcatt caagctatac
    34021 tcgtgaaact cagccttatg tttacggaga ttactctatc tttttggctg agattgcctc
    34081 aactaccaat gaaaatatct tgacggagaa attattggaa gaagtggaag acgacgcaac
    34141 acgctttgct attctcaata acttcctaga tggtttccgt ggaacagttt tccgccaaac
    34201 tcaatttgct gagtttgaac acgccattca ccaagcagat caaaatgggg aggtcttgac
    34261 aagcgatttc ctaaataaac tctacgcaga cttgaaccaa gagtattatg gtttgagtaa
    34321 ggaagacaat cctgaaatcc aatacgagtg ggctcgcatt ccacacttct actataacta
    34381 ctatgtatat caatattcaa ctggctttgc ggccgcctca gccttggctg aaaaaattgt
    34441 ccatggtagt caagaagacc gtgaccgcta tatcgactac ctcaaggcag gtaagtcgga
    34501 ctatccactt aatgtcatga gaaaagctgg tgttgatatg gagaaggaag actacctcaa
    34561 cgatgccttt gcagtctttg aacgccgttt aaatgagttt gaagcccttg ttgaaaaatt
    34621 aggattagca taaaatggtt gaatcgtata gtaagaatgc taaccataac atgcgtcgtc
    34681 ctgtcgtcaa agaagaaatt gtagacttga tgcgtcagcg tcaaaagcaa gtcacaggtt
    34741 tcttgaaaga attggaagat tttgcccgca aggaaaatat tcctattatt ccccatgaaa
    34801 cggttgctta tttccgtttt cttatggaaa ccatgcagcc taaaaatatt ctggaaattg
    34861 ggacggctat cggtttttca gctctcttga tggctgaaca tgcgccaaat gctaagatta
    34921 caactattga tcgtaatcca gaaatgattg gttttgccaa ggaaaatttt gcccagtttg
    34981 acagtcgcaa gcaaatcact ctcctagagg gagatgcggt ggatgtctta tctacactga
    35041 cagagtctta tgatttcgtc tttatggatt ctgccaagtc taaatacatc gtctttctgc
    35101 cagaaatcct caaacatttg gaagttggtg gtgtggttgt cttggatgat atttttcaag
    35161 gtggtgatgt tgccaaggat attatggaag tccgtcgtgg tcagcgaacc atttatcgag
    35221 gccttcaaaa attatttgat gcaaccttag acaatccaga actcaccgca acattagtgc
    35281 ctttaggaga tggtattctc atgcttcgta aaaaggtagc agatgttcaa ctgtctgaaa
    35341 gcgaatgatt ttcagaaaaa tttaagaaaa aatagtaaaa tagatagggt aacacttatc
    35401 tcaaaggagt agacatgaag aaaaaactat tggcaggtgc catcacacta ttatcagtag
    35461 caactttagc agcttgttcg aaagggtcag aaggggcaga ccttatcagc atgaaagggg
    35521 atgtcatcac agaacatcaa ttttatgagc aagtgaaaag caacccttca gcccaacaag
    35581 tcttgttaaa tatgaccatc caaaaagttt ttgaaaaaca atatggctca gagcttgatg
    35641 ataaagaggt tgatgatact attgccgaag aaaaaaaaca atatggcgaa aactaccaac
    35701 gtgtcttgtc acaagcaggt atgactcttg aaacacgtaa agctcaaatt cgtacaagta
    35761 aattagttga gttggcagtt aagaaggtag cagaagctga attgacagat gaagcctata
    35821 agaaagcctt tgatgagtac actccagatg taacggctca aatcatccgt cttaataatg
    35881 aagataaggc caaagaagtt ctcgaaaaag ccaaggcaga aggtgctgat tttgctcaat
    35941 tagccaaaga taattcaact gatgaaaaaa caaaagaaaa tggtggagaa attacctttg
    36001 attctgcttc aacagaagta cctgagcaag tcaaaaaagc cgctttcgct ttagatgtgg
    36061 atggtgtttc tgatgtgatt acagcaactg gcacacaagc ctacagtagc caatattaca
    36121 ttgtaaaact cactaagaaa acagaaaaat catctaatat tgatgactac aaagaaaaat
    36181 taaaaactgt tatcttgact caaaaacaaa atgattcaac atttgttcaa agcattatcg
    36241 gaaaagaatt gcaagcagcc aatatcaagg ttaaggacca agccttccaa aatatcttta
    36301 cccaatatat cggtggtgga gattcaagct caagcagtag tacatcaaac gaatagtcca
    36361 aatcaatgaa tcagggaaaa aactcgactt caggaaaaaa tgaagcaaac attcccacaa
    36421 taaaacgcgt agtacaaggt ttgtactgac ccccaaaagt tagacaaata atttatccga
    36481 aggatttagt tctgtattgc acagggctaa gtccttttag ttttacctta attctcttgt
    36541 tgttgtaata atcaatatag tctataatgg cttgttccaa ttgattaagt gatttaaatg
    36601 ttttctcata gccataaaac atttcggatt ttaaaatacc aaagaaagat tccatcctac
    36661 cgttgtcttg gctgtttccc ttgcgtgaca tagatgcttg aattccctta ctctctagga
    36721 accgatgata agaatcgtgt tggtattgcc agtcttggtc actatggaga atcgtattct
    36781 cgtagtgctt ctctttgaat gcctgttcca aca
//
LOCUS       DAVHSO010000016        34637 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.016, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000016 DAVHSO010000000
VERSION     DAVHSO010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34637)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34637)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34637
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.016"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(191..538)
                     /locus_tag="VVR18_000755"
     CDS             complement(191..538)
                     /locus_tag="VVR18_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU6032323.1"
                     /translation="MNLNQLDIIVSNVPQVCADLEHILDKKADYADDGFAQFTIGSHC
                     LMLSQNHLVPLENFQSGIIIHIEIEDVDQNYKRLNELGIKFLHGPTVTDWGTESLLVQ
                     GPAGLVLDFYRMK"
     gene            complement(649..2424)
                     /gene="spxB"
                     /locus_tag="VVR18_000756"
     CDS             complement(649..2424)
                     /gene="spxB"
                     /locus_tag="VVR18_000756"
                     /EC_number="1.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate oxidase"
                     /protein_id="HEU6032324.1"
                     /translation="MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKD
                     IRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAIL
                     GSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAISKKGPAVV
                     EIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGV
                     KAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLF
                     LGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPV
                     ESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTT
                     QTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPD
                     VITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFT
                     VDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKE
                     KYEAEELVPFRLFLEEEGLQSRAIK"
     gene            complement(2631..4874)
                     /locus_tag="VVR18_000757"
     CDS             complement(2631..4874)
                     /locus_tag="VVR18_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HEU6032325.1"
                     /translation="MTEIVKASLENGIQKIRIRAEKGYHPAHIQLQKGIPAEITFHRA
                     TPSNCYKEILFEEEGILEPIGVDEEKVIRFTPQELGRHEFSCGMKMQKGSYIVVEKTR
                     KSLSLLQRFWITSIFTVPLVILMIGMLTGSISHQVMHWGTFLATTPIMLVAGKPYIQS
                     AWASFKKHNANMDTLVALGTLVAYFYSLVALFAGLPVYFESAGFILFFVLLGAVFEEK
                     MRKNTSQAVEKLLDLQAKTAEVLSDDSYVQVPLEQVKVGDLIRVRPGEKIAVDGVVVE
                     GVSSIDESMVTGESLPVDKTVGDTVIGSTINHSGTLVFRAEKVGSETVLAQIVDFVKK
                     AQTSRAPIQDLTDKISGIFVPVVVILGIMTFWVWFVLLRDSVVVLGASFVSSLLYGVA
                     VLIIACPCALGLATPTALMVGTGRSAKMGVLLKNGTVLQEIQKVQTLVFDKTGTLTEG
                     KPVVTDIIGDEVEVFGLAASLEDASQHPLAEAIVKRASEAGLEFQTVENFQSLHGKGV
                     SGRINGKQVLLGNAKMLDGMDISNTYQDKLEELEKEAKTVVFLAVDNEIKGLLALQDI
                     PKENAKLAISQLKKRGLRTVMLTGDNAGVARAIADQIGIEEVIAGVLPEEKAHEIHKL
                     QQSGKVAFVGDGINDAPALSVADVGIAMGAGTDIAIESADLVLTTNNLLGVVRAFDMS
                     KKTFHRILLNLFWAFIYNVVGIPIAAGVFSGVGLALNPELAGLAMAFSSVSVLTSSLL
                     LNFSKID"
     gene            complement(4884..5255)
                     /locus_tag="VVR18_000758"
     CDS             complement(4884..5255)
                     /locus_tag="VVR18_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupredoxin domain-containing protein"
                     /protein_id="HEU6032326.1"
                     /translation="MLNSIVTIICIALIAFILFWFFKKPEKSGQKAQQKNGYQEIRVE
                     VMGGYTPELIVLKKSVPARIVFDRKDPSPCLDQIVFPDFGVHANLPMGEEYVVEITPE
                     QVGEFGFACGMNMMHGKMIVE"
     gene            complement(5266..5661)
                     /locus_tag="VVR18_000759"
     CDS             complement(5266..5661)
                     /locus_tag="VVR18_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopY/TcrY family copper transport repressor"
                     /protein_id="HEU6032327.1"
                     /translation="MQISDAEWQVMKIIWMQGEQTSTDLIRVLAERFDWSKSTVQTLL
                     ARLVEKECLTRKKEGKSFVYSALLTLDQSRDLLVQDIKDKVCSRRIRNLLADLIVECE
                     FTQTDLEDLEAVISEKKSSAVTEVRCNCM"
     regulatory      5845..5943
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            6027..6818
                     /gene="thiD"
                     /locus_tag="VVR18_000760"
     CDS             6027..6818
                     /gene="thiD"
                     /locus_tag="VVR18_000760"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEU6032328.1"
                     /translation="MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVA
                     QNTRGVQLIEHVSPQMLKAQLESVFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDCPY
                     VLDPVMVATSGDALIDSSARDYLKTNLLPLATIITPNLPEAEEIVGFSIHDPEDMQRA
                     GRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESPRIQTCHTHGTGCTFAAVI
                     TAELAKGKSLYQAVDKAKAFITKAIQDAPQLGHGSGPVNHTTFKD"
     gene            complement(7028..7660)
                     /locus_tag="VVR18_000761"
     CDS             complement(7028..7660)
                     /locus_tag="VVR18_000761"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HEU6032329.1"
                     /translation="MNREALRLYLVTNRYQDSVESFLAKVETACRSGVTIVQLREKNL
                     TTNQYYQLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARKVLGP
                     EKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLKTICQTVAIPV
                     VAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQAFLTKLHDILS"
     gene            complement(7653..8456)
                     /locus_tag="VVR18_000762"
                     /pseudo
     CDS             complement(7653..8456)
                     /locus_tag="VVR18_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155192.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
     gene            complement(8456..8980)
                     /gene="thiW"
                     /locus_tag="VVR18_000763"
     CDS             complement(8456..8980)
                     /gene="thiW"
                     /locus_tag="VVR18_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001225563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy coupling factor transporter S component
                     ThiW"
                     /protein_id="HEU6032330.1"
                     /translation="MRKHQLQVHKLTILSMMIALDVVLTPIFRIEGMAPMSSVVNILA
                     GIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAGLFYKYGRKFYFSALGE
                     IVGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEF
                     FKKVQGYFFAERIE"
     gene            complement(8985..9677)
                     /gene="tenA"
                     /locus_tag="VVR18_000764"
     CDS             complement(8985..9677)
                     /gene="tenA"
                     /locus_tag="VVR18_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiaminase II"
                     /protein_id="HEU6032331.1"
                     /translation="MEFTDIAMELSKKAWQASFHHPFILQLQEGNLEPAIFRYYLIQD
                     AYYLKAFSEIYHLLADKTSNQEMKRLLKQNAQGLVEGELFIRQQFFKELEISDQEMEQ
                     HPIAPTCYHYISHIYRQFAEPNLAIAFASLLPCPWLYHDIGKSLNLKPSPNPLYQQWI
                     ETYITDELEQQIREEGALVNQLYRESDETDKQKMLDAFHISVHMEAKFWEMAYQHQTW
                     KSDLQSLEKGEE"
     gene            complement(9688..10338)
                     /locus_tag="VVR18_000765"
     CDS             complement(9688..10338)
                     /locus_tag="VVR18_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt ABC transporter permease"
                     /protein_id="HEU6032332.1"
                     /translation="MVKVATQTPIISLFLLILSLETSFIPSIALNLSVVAFCILFMLY
                     YRRFKMLAWMIILAILPSFANYWAVQLHGDASQAVMLGTRAFVTVCIGLVFVSSISLK
                     ELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKV
                     LMTVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFL"
     gene            complement(10340..11725)
                     /locus_tag="VVR18_000766"
     CDS             complement(10340..11725)
                     /locus_tag="VVR18_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032333.1"
                     /translation="MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQMI
                     AQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILLQNLNHQFTMENLFEELIFTLENI
                     GYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
                     ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPS
                     YEMTQVASKEVASSPELFHMNRVTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTL
                     FRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDS
                     ERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDD
                     RACHYFCKWIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLT
                     SQSSNTQGEVR"
     gene            complement(11726..12286)
                     /locus_tag="VVR18_000767"
     CDS             complement(11726..12286)
                     /locus_tag="VVR18_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU6032334.1"
                     /translation="MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQ
                     AFANEILFGLWCMAAPIAAIFVPRVGSATIGEVLAALAEVLYGSQFGLGALLSGLVQG
                     LGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRFI
                     SVYFFCTILVRAIVKLYHQFATGGKA"
     regulatory      complement(12549..12637)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            complement(12846..13475)
                     /locus_tag="VVR18_000768"
     CDS             complement(12846..13475)
                     /locus_tag="VVR18_000768"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000468574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HEU6032335.1"
                     /translation="MFHKELLKLYFICGTTTCQGKNLYTVVEEALKGGITLFQFREKG
                     EGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRK
                     LMPDKIIGLSIKNEEEFQQSKVEYVDYVGVGPVFDTQSKDDAGGAIGYEGVKLMRKLL
                     PQMPLVAIGGIQTKHIKDIIKTNMDGVSIISAISYAKNIEKTVREMSEQ"
     gene            complement(13477..14259)
                     /gene="thiM"
                     /locus_tag="VVR18_000769"
     CDS             complement(13477..14259)
                     /gene="thiM"
                     /locus_tag="VVR18_000769"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HEU6032336.1"
                     /translation="MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPA
                     DLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKKVA
                     DDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVT
                     GEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVVASFIGLEKGQELKSLETAMLVY
                     NIAGEMAEKRPNGHLPGTFKVEFINALYEITDEDVKEFKRVK"
     gene            14350..14436
                     /locus_tag="VVR18_000770"
                     /pseudo
     CDS             14350..14436
                     /locus_tag="VVR18_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(14586..15254)
                     /locus_tag="VVR18_000771"
     CDS             complement(14586..15254)
                     /locus_tag="VVR18_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TenA family protein"
                     /protein_id="HEU6032337.1"
                     /translation="METQDYAFQPGLTVGELLKSSQKDWQAAINHRFVKELFAGTIEN
                     KVLKDYLIQDYHFFDAFLSMLGACVAHADKLESKLRFAKQLGFLEADEDGYFQKAFKE
                     LKVAENDYLEVTLHPVTKAFQDLMYSAVASSDYAHLLVMLVIAEGLYLDWGSKDLALP
                     EVYIHSEWINLHRGPFFAEWVQFLVDELNRVGKNREDLTELQQRWNQAVALELAFFDI
                     GYDV"
     regulatory      complement(15469..15557)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            complement(15809..16945)
                     /gene="lctO"
                     /locus_tag="VVR18_000772"
     CDS             complement(15809..16945)
                     /gene="lctO"
                     /locus_tag="VVR18_000772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate oxidase"
                     /protein_id="HEU6032338.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTF
                     TLRENIRAFNHKLIVPHTLCNVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVA
                     TARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEG
                     YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSP
                     RDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQE
                     VAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEH
                     LNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY"
     gene            complement(17569..19059)
                     /gene="lysS"
                     /locus_tag="VVR18_000773"
     CDS             complement(17569..19059)
                     /gene="lysS"
                     /locus_tag="VVR18_000773"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HEU6032339.1"
                     /translation="MSTEHMEELNDQQIVRREKMAALREQGIDPFGKRFERTANSQEL
                     KDKYANLDKEQLHDKNETATIAGRLVTKRGKGKVGFAHLQDREGQIQIYVRKDAVGEE
                     NYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
                     YRKRYLDLISNRESFERFVTRSKIISEIRRYLDQKGFLEVETPVLHNEAGGAAARPFI
                     THHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQ
                     AYADFQDIMDLTEGIIQHAAKSVKGDGPVNYQGTEIKINEPFKRVHMVDAIREITGVD
                     FWQDMTLEEAKAIAAEKKVPVEKHYTEVGHIINAFFEEFVEETLIQPTFVYGHPVAVS
                     PLAKKNPEDQRFTDRFELFIMTKEYGNAFTELNDPIDQLSRFEAQAKAKELGDDEATG
                     IDYDYIEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK"
     gene            complement(19187..19333)
                     /locus_tag="VVR18_000774"
     CDS             complement(19187..19333)
                     /locus_tag="VVR18_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate oxidase"
                     /protein_id="HEU6032340.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAGDTF
                     TSFQ"
     gene            19549..20229
                     /locus_tag="VVR18_000775"
     CDS             19549..20229
                     /locus_tag="VVR18_000775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6032341.1"
                     /translation="MDWSIVEQYLPLYQKAFFLTLHIAVWGILGSFLLGLIVSIIRHY
                     RIPVLAQVATAYIELSRNTPLLIQLFFLYFGLPRIGIVLSSEVCATLGLVFLGGSYMA
                     ESFRSGLEAISQTQQEIGLAIGLTPLQVFRYVVLPQATAVALPSFSANVIFLIKETSV
                     FSAVALADLMYVAKDFIGLYYETDIALAMLVVAYLIILLPISLVFSWIERRLRHAGFG
                     NPSTLSGK"
     gene            20189..20866
                     /locus_tag="VVR18_000776"
     CDS             20189..20866
                     /locus_tag="VVR18_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001154125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6032342.1"
                     /translation="MQDSGIQVLFQGNNLLRILQGLGVTIEISILSVLLSMMFGTVMG
                     IIMTSHSRIIRFLTRLYLDFTRIMPQLVLLFIVYFGLARNFNINISGETSAIIVFTLW
                     GAAEMGDLVRGAITSLPKHQFESGQALGLTNVQLYYHIIIPQVLRRLLPQAINLVTRM
                     IKTTSLVILIGVVEVTKVGQQIIDSNRLTIPTASFWIYGTILVLYFAVCYPISKLSTH
                     LEKHWRN"
     gene            20867..21624
                     /locus_tag="VVR18_000777"
                     /pseudo
     CDS             20867..21624
                     /locus_tag="VVR18_000777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000401.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
     gene            21636..22496
                     /locus_tag="VVR18_000778"
     CDS             21636..22496
                     /locus_tag="VVR18_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6032343.1"
                     /translation="MKLFKPLLTVLALAFALIFITACSSGGNAGPSSGKTTAKARTID
                     ENKKSGELRIAVFGDKKPFDYVDNDGSYQGYDIELGNQLAQDLGVKVKYISVDAANRA
                     EYLISNKVDITLANFTVTDERKKQVDFALPYMKVSLGVVSPKTGLITDVKQLEGKTLI
                     VTKGTTAETYFEKNHPEIKLQKYDQYSDSYQALLDGRGDAFSTDNTEVLAWALENKGF
                     EVGITSLGDPDTIAAAVQKGNQELLDFINKDIEKLGKENFFHKAYEKTLHPTYGDAAK
                     ADDLVVEGGH"
     gene            complement(22576..23223)
                     /locus_tag="VVR18_000779"
     CDS             complement(22576..23223)
                     /locus_tag="VVR18_000779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032344.1"
                     /translation="MNEIITLKNIELKLKKTCVFQNLNFSCKQGEIIGITGANGSGKS
                     VLFKLIAGLYSPSYGEVLINGENIVPERKIPTNLGALIEEPGFINYYSGFKNLQYLAS
                     IRGVVGNQEINDTLKIVGLYEQKDQKVKTYSLGMRKKLGIAQAIMENPSILLLDEPMN
                     ALDKSSVENMRTLFRKLSSEKGTTILIASHSEEDIRILCDKVYAIEDKVCTLCSD"
     gene            complement(23220..23918)
                     /locus_tag="VVR18_000780"
     CDS             complement(23220..23918)
                     /locus_tag="VVR18_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032345.1"
                     /translation="MGKLSSHMWRLNQIIYTKYFWGYVLFWILICLGLWYWLEGNDRL
                     VIEILKGPNLSQNSFLVLSIWLLHWFIIHTFFLAVVYRRRASDFFMEVIRFSSIKLWI
                     RYQIWTCFLYGLILIMVKVLVIQFMLQLPNWDIGVLFIVDSLNACVLVLFCFMLYALG
                     ANVQMNFACVSFFLLMIVFGGLFVGNRTNYLFYILNRGNGDIGRDLFLQLLFLVFLFQ
                     SIFYFTRQKRRFIE"
     gene            complement(23928..24680)
                     /locus_tag="VVR18_000781"
     CDS             complement(23928..24680)
                     /locus_tag="VVR18_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032346.1"
                     /translation="MKQFVQFYKKDFLAVLVYFILLLSCVLSSTVYLLRCRQYSIHPN
                     VLEWILVLLQDMTTGVYCFPFTYILFFFYLMNNYFNRLECRIRLKSIKHFTSFSFKLA
                     ALSTGIWTATLFLLIFLIAFSNGFSFSLEIKEVDFLREFYGISIANNASFFIGFFFSY
                     IAYYFFLSLLTISSFSWFKKSNMSLVFLFTFLFVESLFWIYQLDNGIIGLLPIFQYMV
                     NSNPYALIYWLTLLSIIIPLTVFSVHRNWRRV"
     gene            complement(24680..25444)
                     /locus_tag="VVR18_000782"
     CDS             complement(24680..25444)
                     /locus_tag="VVR18_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032347.1"
                     /translation="MEFFICNLVRVVQSPRFYMSLFLTLLCMSLGNFLAFNGIYKIEG
                     LSIFFAASSIRGFSPISLVAALICTLPYSSQIIEDAESHFLTAQLCRISKKRYLAIVG
                     STAIISSFLVFFLPYLLLLGINLLVTPYQEIYIGDYSGALKELFDSNQFLYGLVTTLW
                     YGVWGAVFSIFGLASALLVKKKIGAIFIPVAYMMVGGIFWAILGLSYLEPVTTLALGY
                     QKDISLSLVSGHLAFILFVSCLVVYGTFFLHSEDYV"
     gene            complement(25540..25943)
                     /locus_tag="VVR18_000783"
                     /pseudo
     CDS             complement(25540..25943)
                     /locus_tag="VVR18_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000829085.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(26123..26755)
                     /locus_tag="VVR18_000784"
     CDS             complement(26123..26755)
                     /locus_tag="VVR18_000784"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HEU6032348.1"
                     /translation="MTLAKDIASHLLKIQSVYLKPEEPFTWASGIKSPIYTDNRVTLA
                     YPETRTLIENGFVEAIKEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDH
                     GAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
                     KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG"
     gene            complement(26789..27490)
                     /gene="pyrF"
                     /locus_tag="VVR18_000785"
     CDS             complement(26789..27490)
                     /gene="pyrF"
                     /locus_tag="VVR18_000785"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HEU6032349.1"
                     /translation="MREHRPVIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAG
                     PEIVSYLKALGHSVFLDLKLHDIPNTVKSAMKILSQLGVDMTNIHAAGGVEMMKAARE
                     GLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEV
                     QVIKQATNPDFICLTPGIRPAGVAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPV
                     AAYHAIKDEWTQDWN"
     gene            complement(27723..28922)
                     /gene="divIB"
                     /locus_tag="VVR18_000786"
     CDS             complement(27723..28922)
                     /gene="divIB"
                     /locus_tag="VVR18_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIB"
                     /protein_id="HEU6032350.1"
                     /translation="MSKDKKNEDKEILEELKELSEWQKRNQEYLKKKAEEEAALAEEK
                     EKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVASSEADKEKEEKEEPES
                     KEKEEQDKKLSKKATKEKPAKAKIPGIHILRAFTILFPSLLLLIVSAYLLSPYATMKD
                     IRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVELAQLVYQFPTK
                     FTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFV
                     SELAQISPELKAAIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKP
                     QLSEPSVIDMEAGIYSYTVADKLIMEAEEKAKQEAKEAEKKQEEEQKKQEEESNRNQT
                     TQRSSRR"
     gene            complement(28932..29990)
                     /locus_tag="VVR18_000787"
     CDS             complement(28932..29990)
                     /locus_tag="VVR18_000787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="HEU6032351.1"
                     /translation="MKKIVFTGGGTVGHVTLNLLLMPKFIEDGWEVHYIGDKRGIEHQ
                     EILKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVGWGIVQSLFIMLRLRPQTLFSKGG
                     FVSVPPVIAARVSGVPVFIHESDLSMGLANKIAYKFATKMYSTFEQASSLSKVEHVGA
                     VTKVSDQKNPEPDELVDIQSHFNHKLPTVLFVGGSAGARVFNQLVTDHKKELTERYNI
                     INLTGDSSLNELSQNLFRVDYVTDLYQPLMELADIVVTRGGANTIFELLAIAKLHVIV
                     PLGREASRGDQIENAAYFVKKGYAEDLQESDLTLDSLEEKLSHLLSHKEDYQAKMKAS
                     TELKSLADFYQLLKKDLS"
     gene            complement(29992..31344)
                     /locus_tag="VVR18_000788"
     CDS             complement(29992..31344)
                     /locus_tag="VVR18_000788"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HEU6032352.1"
                     /translation="MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFE
                     DNPAAQSLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYNNPMIEKALAKGIPVLTE
                     VELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIASD
                     KDTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGSFSEYVAAKWNIQNKMTAAD
                     FLVLNFNQDLAKDLTSKTEATVVPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPG
                     SHNVENALATIAVAKLRGVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNI
                     LATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKA
                     GVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
                     "
     gene            complement(31448..32089)
                     /locus_tag="VVR18_000789"
     CDS             complement(31448..32089)
                     /locus_tag="VVR18_000789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032353.1"
                     /translation="MIELKNISKKFGSRQLFSDTNLHFEGGKIYALIGTSGCGKTTLL
                     NMIGRLEPYDKGQIIYDGTSLKDIKPSVFFRDYLGYLFQDFGLIESQTVKENLNLGLV
                     GKKLKEKEKISLMKQALNRVNLSYLDLKQPIFELSGGEAQRVALAKIILKDPPLILAD
                     EPTASLDPKNSEELLSILESLKNPNRTIIIATHNPLIWEQVDQVIRVTDLSHR"
     gene            complement(32091..34112)
                     /locus_tag="VVR18_000790"
     CDS             complement(32091..34112)
                     /locus_tag="VVR18_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000732428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU6032354.1"
                     /translation="MKKLFILLSTFFLSFFFAWIIVLRAPQYLYASYDSVTLLRVKKE
                     AQEPTREVFEQELEKFVNSEQSLIARRIVEPSKDGTTHFTYATYGQGTLPKQFQEASQ
                     ESRERSDPLNSYLLLSGSLTKEKLADKLGDLGYKAIADRKTPPYSLAFRMLLNPLILI
                     SLAIFGLSFFALVIITRIKEMRAAGIKLFSGQTLLSIMGHSLSTDIKWLLLSALLSFL
                     GGGVVLFSQGLFYPILLATYGFGISFYLLFLLAISILLMLLYLMSLSYKALVPVIKGR
                     LPLKRLMILTLLCQLVAVFTVGYAVKTGLTSYQRLKELEISKQAWHDRVDYYQISFGL
                     GDRVNDTENQNKWYEFSKEAVEKEQALFVKENLIHFANPQGKNENGETLDTYSPDANV
                     LYVSPSYLDKENVAVNDETRQKLAHLQKGEFGLLLPESLRSQEAELKKVFEERLNYYG
                     KSSEDKDAPLEYEMRAIVSYLPTGQKRFVYNNGESPVSIQYLTDPILVVFTPTSTGDS
                     FISKYVWSINAGKQLFIKGYESGLELLKKAGIYEQVSYLKEGRSVYLTRYNEVQTETA
                     TLILGAIVGIASSLLLFYSVNLLYFEQFRRDILIKRISGLRFFETHAQYMVSQFASFV
                     FGASFFILSSRDLVIGLLTLFVFLASAVLTLYRQAQKESRVSMTIMKGK"
     gene            complement(34183..34482)
                     /locus_tag="VVR18_000791"
     CDS             complement(34183..34482)
                     /locus_tag="VVR18_000791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEU6032355.1"
                     /translation="MKTKKHRLLALALISSFTLLGAASAAVQYPDGGVWTYGEGSGGG
                     WAFSNYYHGKKYHYSSVVSKWDSHSDKGSAPAGKTSEAWIWTKFGEQVSFYYDYD"
BASE COUNT        10539 a         7528 c         6218 g        10352 t
ORIGIN      
        1 aaggattgga gaaggaggtg ataaagtcca tcgttaatcg gagatggact agaatgcttt
       61 ttgaaagcag atgagtatta tatgcaattt ctttatataa aaagaccgga ttgctccgat
      121 ctttcaatag ttcatattct caatttctat tttaaaaata gctaaggtta acgtcaaatg
      181 actacgcgac ctatttcata cgataaaaat caagcactag accagcaggt ccttgaacta
      241 ataaggactc tgttccccaa tcggttacag ttggtccgtg taaaaacttt ataccaagct
      301 cgttcaaccg tttgtagttc tggtctacat cctcaatctc gatatgaata atgattcctg
      361 actgaaagtt ttccaaagga accaaatgat tttgtgacaa cataaggcag tgactaccaa
      421 tcgtaaactg agcaaaacca tcatcagcat aatctgcctt tttatccaag atatgctcca
      481 agtcagcaca gacttgggga acatttgaaa cgataatatc taattgattt aaattcattt
      541 actctcctcc ataaaaagac cggattgctc cgatctttta aagttctgct ctatgaaaat
      601 caaagaataa agtctacaag tttcatattt gattttcggc gagaggaatt atttaattgc
      661 gcgtgattgc aatccttctt cttccaagaa gagacggaat ggtacgagtt cttctgcttc
      721 gtatttttcc ttgaaggctt tgatagcttc ttctgagtga agttttggat ccaattcaag
      781 tacttctact ggaagtggac ggtgttgagt gatgcgagca tcgatgacaa cagttttacc
      841 ttctttgttc aatttaacag cttctgcaac aactgcatcg atgtcttcga tacggtcaac
      901 tgtgaatcca acagctcctt gagcttccgc aattttagcg tagtcagcgt ttgtgaagtc
      961 tacaccaaac aagtgtttgt ttgtatcttc gtatttgttc ttgatgaagc cgtactcagc
     1021 atttgagaag acaaggttga taactggaag gtcgtattga acgtttgtga taacgtctgg
     1081 gtagcacatg ttgaatgctc cgtcacccat gatgttccat acttggcgat ctggattgtc
     1141 tttcttagca gcgataccac caggaagggc aatacccatt gtcgcaaaga gtggagatgt
     1201 acgccacatg ttcttaggtg tcatgtgaag gtgacgagta gatgtttgag tagtgttacc
     1261 tacgtcgatt gagtagatag cgtcttgatc agcatgtttg ttgattgcat tgtaaacttg
     1321 atacaattgc aattcaccct cagttttacc ttcgagtttg ttcatgtaat cacgccagtt
     1381 ttggttgttc ttaacgtttg cacgccacca tggagttgat tcaactgggt ttactttgtc
     1441 aaggatagct ttagctgctt gaccagcatc accaaggatt gaagcgtcaa gggcatgacg
     1501 tttaccaagt ttgtaagggt cgatatcgac ttggatgaat ttttcagtgt tcttgaatgc
     1561 ttcgtaaact tcagcaaatg ggaagtttga accaaggaaa agaactgtgt ctgcttcaaa
     1621 gaccacttcg ttggctggtt tccaaccaac acggtaagca gaacctgtca aaccttcata
     1681 gttccattcg aaagcttcaa agtttttacc agttgtgatg attggtgctt tgattttacg
     1741 tgacaattca gtaatcactt caccagcttt aacaccacca aatccagcat agataactgg
     1801 gcgttcagca ttgttcaaga tttcaacagc tttgtcgatt tcaacttcgt tcaaagcagg
     1861 agcgatgaat gagcgttcgt atgaacctga accgtagtat gagttttcgt cgatttcttg
     1921 gaaaccgaag tttactggaa tttcaacaac agctggacct tttttagaaa ttgcagcacg
     1981 gcaggcttcg tcaattactt ttggcaattg ctcagcgtaa gctacacgtt tgttgtaaac
     2041 agcgataccg ttgtacattg ggttttggtt aagctcttgg aaagcatcca tgttcaattc
     2101 gttaactgga cgcgatccaa ggatcgctag gaatggagtg ttatccatag ctgcatcgta
     2161 aacaccgtta atcaagtgag tcgcacctgg accacctgaa ccaactgcaa ccccgattga
     2221 gccgccgaat ttagcttgca taaccgctgc aagagcacct gtctcttcgt ggcgaacttg
     2281 taagaagcgg atatctttgt cttcagccaa agcgtccatc aatgagctga gtgttcctga
     2341 tgggataccg tagattgtat ctacgcccca tgttttcaat acgttaagca ttgctgcaga
     2401 tgcagtaatt ttcccttgag tcataatgat aactctcctt caattttttt agatttggag
     2461 aatacgatta catagaattg gaaacgttct ccaaattttt actattccac tgtatcatat
     2521 ttatgctgac ttttctaaaa atctgctcaa aactctctat tctctattct aatacagttt
     2581 tgaaagttct gtcatttctg ttttataaca aagaaatcta gtcattactt ttagtctatt
     2641 ttactaaaat ttaacagaag ggaactggtc agaacagata cagaactaaa ggccatggct
     2701 agacctgcca attctgggtt gagagccagt ccaacacctg aaaagactcc tgctgcaatc
     2761 ggaattccga caacattgta gataaaggcc cagaaaagat tgagtagaat tcgatgaaag
     2821 gttttcttac tcatgtcgaa ggcacgaacc actcctaaaa gattattggt tgtcaacacc
     2881 aaatctgctg actcgatggc gatatctgtt ccagctccca tagcaatccc cacatctgct
     2941 acactaaggg caggagcgtc attgataccg tccccaacaa aggctacttt ccctgactgt
     3001 tgcagtttat ggatttcatg ggctttttct tctggcaaga cgcctgcaat gacctcttca
     3061 attccgattt gatctgcaat agcacgcgcc acaccagcat tgtctcctgt cagcatgact
     3121 gttcggagac cacgtttttt tagctgactg atggctagct tagcattttc cttaggaata
     3181 tcttgcaaag caagcaagcc tttgatttca ttgtcaacag ctaagaacac aactgtctta
     3241 gcttcttttt ctagttcttc tagtttatct tgataagtat tagaaatatc cataccatcc
     3301 agcattttag catttccaag taaaacttgt tttccattga ttcgccctga aacacctttc
     3361 ccgtgcaagg actgaaaatt ttcaacagtt tgaaactcaa gtccagcttc actcgctcgc
     3421 ttaacgatag cctcagccag tgggtgttga gaagcatctt ccaaggaggc tgccaatcca
     3481 aacacttcta cttcgtcgcc gatgatatct gttaccacag gtttcccttc cgtcaaagtc
     3541 ccggtcttat caaagacaag agtttgaact ttctggattt cctgtaagac agttccattt
     3601 ttgaggagaa cccccatctt ggcactacgt cctgtcccca ccataagggc tgtcggtgtt
     3661 gcaagtccca aggcacaagg acaggcgata atcaaaaccg ccactccgta gagaagagag
     3721 gacacaaagc tagctccaag cacgaccaca ctatccctga gcaagacgaa ccaaacccaa
     3781 aaggtcatga ttcctaaaat gacaactact gggacaaaaa tccctgaaat cttatccgtc
     3841 aagtcctgaa tcggcgcacg acttgtctga gctttcttca caaaatccac aatctgagcc
     3901 aaaacagtct ctgagccaac tttttctgct ctaaagacaa gcgttccact atgattgatg
     3961 gttgagccaa tgacagtatc tccaactgtc ttgtccacag gcagactctc acctgtcacc
     4021 atggattcgt caatactaga gacaccttct actacgacac catcaacagc aatcttttca
     4081 ccgggacgca ctcgaatcag gtcgcctacc ttgacttgtt ccaaaggaac ttggacataa
     4141 ctatcatcac tcaagacttc tgcggtttta gcttgcaagt ccagtaattt ctccacagct
     4201 tgggacgtat tttttctcat tttttcctca aaaactgctc ccaaaagaac gaaaaagagg
     4261 ataaatccag cactttcgaa gtaaacaggg agaccagcaa agagagcaac taggctatag
     4321 aaataagcca ctagagttcc cagcgcaacc aaggtatcca tgttggcatt gtgcttttta
     4381 aaactggccc aagcactctg gatatatggc ttacctgcaa ctaacataat aggcgttgtt
     4441 gctagaaagg ttccccaatg catgacttga tgactaatgc tacctgtcaa catcccaatc
     4501 atgagaatca caagaggcac agtaaagata ctagtaatcc aaaaacgttg caggagagat
     4561 agagattttc gagtcttctc aacgactata tagcttccct tttgcatctt catgccacaa
     4621 gaaaattcat gtcgccctaa ttcttgaggt gtaaaacgaa tgactttctc ctcatctacg
     4681 ccgattggtt ccaagatacc ttcttcttca aacagaattt ccttataaca gtttgaagga
     4741 gtagcacgat gaaaggtaat ctcagctgga attccctttt gaagctggat atgggctgga
     4801 tgatagcctt tttcagctcg gatacggatt ttttgaatgc cattttctaa gcttgctttc
     4861 acaatttctg tcatagtctc cacctactct acaatcatct tgccgtgcat catgttcata
     4921 ccacaagcaa agccaaactc tccaacctgc tcaggcgtga tttccactac atactcttcc
     4981 cccattggca ggttcgcatg tacaccaaaa tctggaaaaa caatttgatc cagacatggt
     5041 gaaggatcct tgcggtcaaa gacaatgcgt gctggcactg atttcttgag gacaatcaac
     5101 tcaggagtat agcctcccat gacttccact cgaatctctt ggtatccgtt tttttgctgg
     5161 gctttttgtc cagatttttc aggctttttg aaaaaccaaa acaagataaa cgcgataagg
     5221 gcaatacaaa taatggttac aatactattt aacatgacgt ctcctttaca tacaattaca
     5281 tcttacttct gttacagcac ttgatttctt ctctgaaatc acagcttcca agtcttccaa
     5341 gtcagtctga gtaaattcac attctacaat caagtcagcc aacaaattcc taatcctacg
     5401 ggaacaaacc ttgtctttga tatcttggac aagtaaatcc cgactttggt ctagagttaa
     5461 aagggctgaa taaacaaagg acttgccttc ttttttccga gtcagacact ctttctcaac
     5521 caaacgagcc aaaagtgtct gaaccgtgga cttggaccag tcaaaccgct ctgccaaaac
     5581 cctaatcaaa tctgtactgg tctgctcccc ctgcatccaa ataatcttca tgacctgcca
     5641 ttctgcatct gaaatctgca ttaccatacc tccaaaatct acatttgtca attacactca
     5701 acagtatact cccaaaatct acatttgtca attatagaaa taatattttc ttcgaaaaat
     5761 agaattttaa tcatttgaaa aacgatttgc agtcaaatat tactatataa acaataaaaa
     5821 tatgctatac taaagaaaaa agaaaacaac cactaggggt gcgtaaagct gagattaacg
     5881 actgttagat ccctctgact caatctaggt aatgctagct gatggaagtg gaaatgataa
     5941 tggggactag cagtcttcta ttgcctttct aaaacagact agcttgttct taagaataca
     6001 aacttcagtt ggttgggagg ttttagatga cttatttacc cgttgctttg accattgcag
     6061 ggactgaccc tagtggtggt gctggcatta tggcagattt aaagtcattc caagcgagag
     6121 atgtctatgg aatggctgtt gtaaccagtc ttgtcgctca aaataccaga ggtgttcagc
     6181 taatcgagca cgtttctcct caaatgttga aagcccaatt ggagagtgtc ttttctgata
     6241 ttccacctca ggctgtaaaa actggaatgt tggctactac tgaaatcatg gaaatcatcc
     6301 aaccctatct taaaaaactg gattgtccct atgtccttga tcctgttatg gttgctacaa
     6361 gtggagatgc cttgattgac tcaagtgcta gagactatct caaaacaaac ttactacctc
     6421 tagcaactat tattacgcca aatcttcctg aagcagaaga gattgttggt ttttcaatcc
     6481 atgaccccga agacatgcag cgtgctggtc gcctgatttt aaaagaattt ggtcctcagt
     6541 ctgtggttat caaaggcgga catctcaaag gtggtgctaa agatttcctc tttaccaaga
     6601 atgaacaatt tgtctgggaa agcccacgaa ttcaaacctg tcacacccat ggtactggat
     6661 gtacctttgc tgcagtgatt actgctgaac tagccaaggg caagagtctt taccaggcag
     6721 ttgataaggc caaggccttt atcacaaaag ctattcaaga tgcccctcaa ctcggtcatg
     6781 gttctggtcc agtcaaccat acaactttta aagattaaga aaaaaaactc tctagttccc
     6841 actttaaggg aattagagag tttttatact cttcgaaaat ctcttcaaac tacgtcagct
     6901 tccatctgca acctcaaaac actgttttga gctgacttcg tcagtcttat ctaaaacctc
     6961 aaggcagtac tttgagcaac ctgcgactag ctttctagtt tactctttga ttttcattga
     7021 gtattaatta ggaaagaatg tcatgcaact ttgttaaaaa ggcttgcgtt tttgcctcaa
     7081 tatcttctgc ttgcatcaaa tcacgtacaa cagctacacc agctatgcca gtgcccataa
     7141 gctgatcaat attctctgat gtcaagccgc caatagcaac tactggaatg gcaaccgttt
     7201 gacaaattgt tttcaaggtt gaaatcaggg tgatgggtgc attttccttg gtggttgtcg
     7261 gaaaaatggc tcctgtcccc aagtaatctg cacctgattt ctccgcttcc agagctcttt
     7321 taaccgtttt agcggtgaca ccgaggattt tttcaggacc caagactttg cgagctaccg
     7381 aaactgggag ttcgtcatct ccaatatgca gaccagcagc atcaaccgca agacaaacat
     7441 ccaaccgatc atcgattatc aaggggacct gataggcatc tgttatttcc ttgacttgtt
     7501 ttgccagttg ataatattga ttggttgtga gatttttttc tcgcaattgg actatggtaa
     7561 cccctgaacg gcaggccgtc tcaacttttg caagaaagct ttccacggaa tcttgatagc
     7621 gattggttac cagatatagt ctaagcgctt ctctattcat aaacctctcc tttgatggta
     7681 tctagccaat tttcatctct tcttaggagc gaaagctgat tgagtacttg gtaacgaaat
     7741 tcttccaatc ccattccttg aacaactatt ttctcagcag cgatattgag ataagagact
     7801 gctaagcaag aagcttcaaa accagtcttt ccttggctga gaaaaacagc tgttaaggct
     7861 ccaaccaagt ctcctgtccc tgttatccag tctaattcag tacagccatt ctcaagtaca
     7921 gcaacttgat tctccgaaac aataaggtcc ttgggacctg tgactaagaa tgacatacca
     7981 ggataggtct gacaccagtc tttcaagact tgaagcaaat cctccgtttc ttaatcttta
     8041 gcactcgcat cgaccccaac gccgtggtgc tttaaaccaa caagacttcg aatttctgac
     8101 atgtttcctt taaggatcgt agggctatag tctaaaaggt ctctgactag tcccttacga
     8161 atgggcgacg ctgatacacc aaccgcatct actaccatcg ggagagaaga ttggtttgca
     8221 tacgaagctg ccatgcggat tgctttttcc ttctcagctg acaaatgccc caaattgatg
     8281 aagagagcct gactttgctt agtaaaatca agaacctcac ggggatcatc tgccatgaca
     8341 ggtttgcatc ccagagccaa aatcccattt gccagcatct cacaagaaat ctcattggtc
     8401 atacagtgaa tgagggaact agagcctata ggaaaaggat ttgtcaatgc ctgcatcatt
     8461 ctatcctttc agcaaagaaa tatccttgca cttttttaaa gaattcctgc ttgattaaaa
     8521 atctaaatgc aataaaggaa atcgctgtac caatcaaggt tgctccgaaa aatcgaggag
     8581 tgtagataaa ccaactaagc ttagcagccg atcctgtaaa gagcaccata acaggatagg
     8641 aaacaataga accaataata cctgttccca caatttctcc caaggcagaa aagtaaaatt
     8701 ttcgaccgta cttataaaag agacctgcta gaagggctcc aaaagtcgct cctgtgagag
     8761 ctaaaggcgg aatcccttga gtcgtcatac ggataaaggc tgtcactgta gccatagcca
     8821 aggcataaac aggtcccatc atgattcccg ctagaatatt gactacactg gacatcggtg
     8881 ccattccctc aatccgaaag ataggtgtaa ggactacatc aagggcaatc atcatagata
     8941 aaatggtcaa tttgtgaact tgtagttggt gctttctcat gtttctattc ttctcctttt
     9001 tctaaagact gtaaatcgct cttccatgtc tggtgttggt aggccatttc ccaaaacttg
     9061 gcttccatat gaacactgat gtggaaggca tctagcattt tttgcttatc tgtctcatca
     9121 ctttctcgat agagctgatt gaccagtgct ccctcctctc tgatctgttg ctctaactca
     9181 tccgtaatat aagtttcaat ccattgttga tagagaggat ttggtgatgg tttaagatta
     9241 agtgatttgc ctatatcatg gtataaccaa ggacaaggaa gcaagcttgc aaaagcgatg
     9301 gctaagttcg gctctgcaaa ttgcctataa atatgagaaa tgtaatgata acaggttgga
     9361 gcgattggat gttgctccat ttcctggtcg ctgatttcca attccttgaa aaattgttgg
     9421 cgaataaata actcaccctc cactaaaccc tgagcatttt gtttcaagag tcttttcatc
     9481 tcttggtttg aagtcttatc agccaaaaga tgatagattt ctgagaaggc cttcagatag
     9541 taggcatcct gaatcaggta atagcggaaa atggcaggtt ctaaattccc ctcttgtaat
     9601 tgtaaaataa agggatgatg aaaggaagcc tgccaagctt tcttggataa ttccatcgca
     9661 atatctgtaa attccataat aactccttta taaaaataga ctggtttgaa gcaataaaaa
     9721 gaaaagcagg tagattaatt ttgttttttt aggaatataa aaagtccgat agctattctt
     9781 caactgtgca tgttcgtcat atccgtgagc agatagagct ctcaggtaaa gatggcgcca
     9841 cctaaagact gtcatcagaa ccttactgta aatcaagggc gaccaaaaat gtagttcttg
     9901 accacgtaat aggcaagctt ctttgaggga cttgatttct tgctgaatga gaggaaaaga
     9961 attgaatacc acaatcaagg cataggacca agagcgtgat agcccctttt gagccaagta
    10021 caagagaagc tcttttagtg aaatagagga aacaaagaca aggccgatac aaactgtcac
    10081 aaaggccctc gttccaagca tgactgcctg tgaagcatct ccgtgtaact gaactgccca
    10141 gtagttggca aaagatggta aaatggcaag tatgatcatc caagctaaca ttttaaatcg
    10201 acggtaatag agcataaaga gaatacaaaa tgcgactacc gaaagattca gagcaatcga
    10261 aggaatgaaa gatgtttcca aggataaaat cagcaagaag agactgataa tcggtgtctg
    10321 ggttgctact ttgaccatac tatctcacct ccccttgggt attgctactc tgagatgtaa
    10381 gtggtttggt aatggtcact tctttcacat gccgaagacc ctgactagtc atctcaatcc
    10441 aataatcaac cacagaaatc aaagggtcta aacgatgact aatgagcaga aaacttcttc
    10501 cttgattcct ctcctccaca atccacttgc aaaaataatg gcaggctcta tcatccaaac
    10561 ctgcaaaagg ttcatctagc aagatcacgg aagccttact ggtcaagatg gtcaagagct
    10621 gaagaatttt ttgctgacca ccacttaatt gatagggact cttatcgact gcctgctcca
    10681 aatcaaaata tcgtaaagct tgaaaaatcc gctgatttct ttcagaatca ggtccatcta
    10741 attgaagctc ctctcgcaga ctgactcgga taaactgctt ctcagcttcc tgaacaacac
    10801 ccgtcagatc acggtacaaa ctctttttct ttttcaggac tgtccccttc catgcaatgc
    10861 gccccttata cttttgaaat tgaagaatag agcgaaagag ggttgatttc ccgacaccat
    10921 tgtcacccag gatacaggaa atcccttgat agaatgtgaa atcagcaatt gaaaagaggg
    10981 ggcgattacc aagctcacca gtcacacggt tcatatggaa tagttccggg ctagaagcaa
    11041 cttcctttga agcaacctgt gtcatctcat aggaagggat ttgaaacact tcccttagtt
    11101 ttccgtctct tagctcaacc atatagtcga tataggcttt atagtcagat aaatcatggt
    11161 cgcacaaaat gactgtcttc ccatcaagag ccaactcttt tagaatctcc aatatctcga
    11221 ttctactctt gcggtcaatg gaagcgaagg gctcatccaa gagatagacc ctaggattca
    11281 tggcaaagag gacagccagc gctgcttttt gcttttcccc acctgatagg tgatgaatgg
    11341 gacggtgtaa gattgcctcg caacgacatt gctggacaac ctctgctatt ttagaatcaa
    11401 tttcctgaag gtgatagccg atattctcca aggtgaaaat caactcctca aacaagttct
    11461 ccatggtaaa ttgatgattg agattttgca agagaatgcc aaccttctgg acacgtgcga
    11521 tgatagaaag ctgactgacc tcgctcccat ctatcaggac ttgaccacta tagggaagag
    11581 aactgacttg ggcaatcatt tgaaagaggc tggattttcc tgaaccactg ctcccaacta
    11641 acaaggtaaa ggcttgcgca tgaaaagtaa aatcaaacgg ctcagagaaa attggggact
    11701 gaatcgctcg tagttccaga cccatctatg cttttcctcc agttgcaaac tgatgataga
    11761 gtttgacaat ggcacgaacc aagatggtac agaagaaata aacagaaata aaacgtacca
    11821 caagcaagga aaggacaaac ggaagggaaa aggcgtagta acctaactta atgtattcat
    11881 agacaaagct aacaagcgta atcccaatac tattagcagt tagagagagc caactttcat
    11941 agcgattctt agttacgata aaaccaaatt cacttcccaa accttgaacc aagccagaca
    12001 aaagagctcc tagaccaaat tggctaccat aaaggacttc agcaagcgca gctagcactt
    12061 ctccaatcgt tgcacttccg actctcggaa caaagatggc agcaatgggc gcagccatac
    12121 accagagacc gaagaggatt tcattggcaa aggcctgcaa accaagaggt gttaagagta
    12181 gactgagaat attatacaca tatcctgaac caacgaaaac cccaccaaaa aagatagaca
    12241 agaaagcaag caagataaca tcttttaact gccatttttt caacataaaa aaactccttt
    12301 ttttaaagaa aagtggggca ctcaagaaga ccgacctaaa tactttgtat agcagactga
    12361 atttagaaca gtacacaaga acactaaaat atttctagaa attaatttga attttctaat
    12421 tgatttgttc gcatcttatt tcaatctact atatcatctt catccagttt cgtaaaagaa
    12481 aaaactctaa ttacagatac gaattagagt tcagcttaca agattagaca gttcttttcg
    12541 acatacgaaa aaaacatttc acatttccct tcgccagtct taactgtatc aggttcaatg
    12601 ggtatcatct cagcctaaag caccccaaat gtctttatta tttaattatg tgattattat
    12661 aacacacatt ttatactagt tcaagaaatt gaactggaaa tacagccttg cactcacaaa
    12721 gacagcagat ctttcttttg caaaaaacaa atgacctgtt tgatgaatta gccattcaag
    12781 ctgaatctgg acatagcttt ttaaaaaagg aaaatcctac ttacttagaa tccaaggata
    12841 gatatctatt gttcactcat ttcccgaaca gttttttcta tattttttgc atacgatatt
    12901 gccgaaatga ttgaaacgcc atccatattg gtctttataa tgtctttaat atgtttcgtc
    12961 tgtatcccac caattgcaac taaaggcatt tgtggcaata gttttctcat caatttaaca
    13021 ccttcataac ctatagcacc accagcatca tcctttgact gggtatcaaa tacaggacca
    13081 acaccaacat aatctacata ttcaactttt gattgttgaa attcttcctc gttttttata
    13141 gaaagaccaa ttattttatc tggcatcaat tttctaattt catcaacacc aatatcatct
    13201 tgacctacat gtacgccatc agcgtcaatt tccattgcta aatctatatc gtcattaacg
    13261 ataaatggaa cattgtattt tttacaaagt tctttaattt ggatagctag ctcaagtttt
    13321 tctaagcctt ctaaagcacc ctcacctttt tctcgaaatt gaaataaggt tataccacct
    13381 tttaaggctt cctcaacgac tgtatataga ttttttcctt ggcaagtagt cgttccacaa
    13441 ataaaatata gttttagtaa ttctttatga aacatcttac ttcactcttt tgaattcctt
    13501 tacatcttca tctgtaatct cgtataaggc atttataaat tcaactttaa atgtcccagg
    13561 aagatgtcca tttggacgtt tttctgccat ttctccagcg atattgtaaa ctaacattgc
    13621 tgtttctaat gatttcaatt cttgaccttt ttctagtccg ataaagcttg ctactacagc
    13681 tcctaataag catcctgtcc caatgacttt cggcatcata gcactaccat tatgaatcgt
    13741 taccacttct ccattaacag caatggcatc cacttcacct gttactacta ttggaatatt
    13801 gaacttctca tttgctgcta gagcaatttc gtcaatatta tctacgcccg cactatctac
    13861 tcctttagat gccacatcta ttcctactaa agaggcaatc tcgccagcat ttcctctaat
    13921 cgctgctagt ttataattgt tgattagatc atctgctact ttttttctat attctcctgc
    13981 tccacaggct acaggatcta aaactgctgg gacattatat ttctccgcaa ttttcagagc
    14041 agcttggtat aatttccaat tttcatctgt caatgttcct atgtttatta ataaaccacc
    14101 agcatacttt aacaaatcct ctaaatctgc tggaaactca ctcatggctg gtgaggcgcc
    14161 cagtgctact aatccatttg ctgtgaaatt ttttactaca tcattggtta tacaaatgac
    14221 caatggtgct ttttctttta ataattttaa acttgtcata ttgaaatcct tccttttcac
    14281 tttatacgat ctactgattt cgatttatct ctatctttcg ttaagaaatt tttttcattt
    14341 acgttgaatg atttatactc aatgaaaatc aaagagcaaa ctaggaggct aaccgcaggt
    14401 tgctcaaaac actgctttga acctgtagat aagactgacg aagtcagctc aaaacactgt
    14461 tttgaggttg tggatagaac tgacgaagtc agtaaccata cctacggcaa ggtgaaactg
    14521 acgtggtttg aagagatttt cgaagagtct tacctcatca aatttgtaaa tatcatgagc
    14581 cttctctaga catcgtaacc aatatcaaaa aaagctaatt ctaaagcgac tgcttgattc
    14641 cagcgttgct gaagttctgt caaatcttct cgatttttac cgacacgatt gagttcgtca
    14701 accagaaatt gaacccactc tgcaaagaaa ggacctctgt ggagattgat ccattccgaa
    14761 tgaatataga cttcaggtag agccaaatct ttagaacccc agtctaaata gagaccttct
    14821 gcaatgacca gcatgaccaa aagatgggca tagtctgatg aagccactgc cgaatacatt
    14881 agatcctgaa aggcttttgt tacagggtgc aaagtcactt ctagatagtc attctctgct
    14941 acttttaact ctttaaaagc cttttggaaa taaccatctt catctgcttc aagaaagcct
    15001 agttgcttgg caaaacgaag cttggattca agtttatctg cgtgagctac gcaggcaccc
    15061 agcatggata agaaggcatc aaagaagtga taatcttgaa tcagatagtc ctttaagacc
    15121 ttattctcaa ttgtccccgc aaaaagttcc ttaacaaaac gatgattgat tgcagcctgc
    15181 caatccttct gactgctttt taataattct ccaacagtca aacctggctg aaatgcatag
    15241 tcttgtgttt ccatatttac ttctcctctc tttacttgtt agtaattaat aaaacagcaa
    15301 gaaatatcaa gcaaaatcgt aattccactt gatcctttta aagcacatcg agagcatttg
    15361 cagagagcta actaaacaag cctatccagt ttatataaac aaaaaactcc aattacaatc
    15421 aagaattaga gttgacttac aagattagat cgttcatttc gccatacgaa aaaacgtttc
    15481 acatttccct tcgccagtct taactgtatc aggttcaatg ggtatcatct cagcttaaag
    15541 caccccaaat gtctctatta tttaattact gaaccagtat agcaaaaaat gaaagcccta
    15601 gcaagatatt tgaccgaaaa atatctttat atagtagatt gaaactagaa tagtacacct
    15661 ctacttctaa aacattgtta gaaatcgatt taactgtcct gattgatttg tcctattctt
    15721 atttcatttt actatagttt tcgatagcga tttattcttc caatacacga agaaaaacct
    15781 ccacattcag tgaaggcaat ctgttttatc aatacaattt taagtcacga gggtcaactg
    15841 ggaaggttgg gttgtatgga ttgtgacgga gcttaaagtg tttgacatct tcaatggtct
    15901 gagctccaga caattgcata actgtcttca attccgcatt caagtgttca aagacttgac
    15961 gcacaccgac actaccaccg agagccaagc cataaataac agggcgacca atagctacca
    16021 agtctgctcc tgaagccaag gctttaaaga cgtgttgacc acgacgaaca ccagagtcaa
    16081 agacaatcgg cacacgtcta tcaactgctt ctgccacttc ttgaagcgag tcaaaggcag
    16141 ctggtccacc gtcgatttga cgaccaccgt ggttggttac ccagatacca gaagctcctg
    16201 cagcaagtga acgttcaacg tcctcacggc attgtggtcc cttgacatac acaggaagac
    16261 cagagtattc agcgataaat tctacatcgc gtggagacaa gcgttgttta gctgatttgt
    16321 aaacaaagtc cattgattta ccagcacctt ctggcaggta ttcttcaaca atcggcatgc
    16381 caactgggaa gacaaaacca ttacgcttat ccacttcacg attcccccct acagtagcat
    16441 ctgccgtcaa gacaatcgct ttataacctt cagccttcac acggtccatg atgtggcggt
    16501 tgataccgtc atccttacta aagtaaaatt ggaaccaatg gggtgtccct tgaagggctt
    16561 cagaaatctc tggaaggtca acagtagagt aagaactggt tgtataaaga gaaccaaact
    16621 catgcacacc acgcgcagtc gccacttccc cctgttcatt tgccaattta tgagccgcaa
    16681 caggtgccat aatgattgga gaagatagtt tttcacctgc aaattcaatc tctgtacttg
    16741 gattttctac attgcaaagt gtatgaggaa cgatgagctt gtggttaaag gcacggatat
    16801 tctctcttaa agtgaaagta tcttccgccc cactagcgat atagccaaat gctgctttag
    16861 gaataacttg ttgcgccatt ggctccaaat cataggtatt gatgaagtct acatgacctt
    16921 ctgcattgct tgttttgtat gacataaact gtcctcctcg attaagtaag cgtttgcttt
    16981 ttactataca actataataa ctcttttttc aatcattttc aagagttttg cttaaaaacc
    17041 atcttatttt ttcatacaat atactagccc tactttcctt aaactctaaa ccttagtcta
    17101 tattaagtga atcgttgaga ttttttgctg ccaggcattt gaactacttt tttatttgct
    17161 gattctatct actaatacta taaaaaacaa gtgaataaga caccagaaca tcctctaata
    17221 ggacctatgg acttatatca gtcccatata tactgtttaa gcaagatact atcctagttg
    17281 acgctaactt cctatcccac ttattaattt tttatttata gtgaatctga acaaatcaat
    17341 tggggaatcc aagtcaattt ctagtacttt ttgaacagtt tcagcgtact atcgtaaaat
    17401 gaaataaaac atgcacaaat tgcttaggga atttaaacca atttctaaca atgtcttaga
    17461 aatcaaagtg tactatttca acttcaatat actacacttc attttctcct taaattcagt
    17521 ctctttttga atcaaaaaat cctctggtaa gagccagagg ataagaattt atttcattgt
    17581 tgggaagagc aatacatcac ggatagttgt tgtatcagtg aggagcatgc agagacggtc
    17641 gataccgatt cccaaaccac ctgttggtgg cataccgtat tcaagagctt caatgtagtc
    17701 atagtcgatt cctgtcgctt catcatcacc aagttctttg gctttagctt gggcttcaaa
    17761 acggctaagt tggtcgattg ggtcgttgag ttcagtaaag gcattaccgt actccttagt
    17821 catgataaag agctcgaaac ggtcagtaaa gcgttggtct tcaggatttt tcttagcgag
    17881 tggagataca gctactggat gtccatagac aaaggttggt tggattaaag tttcttcaac
    17941 aaactcttca aagaaggcat tgatgatgtg accaacctca gtgtagtgtt tctcaactgg
    18001 aactttcttc tcagcagcga tagctttagc ttcttctaaa gtcatgtctt gccagaaatc
    18061 gacaccagta atttctctga tagcatccac catatgaaca cgcttaaatg gttcgttaat
    18121 cttgatttca gtaccttggt agttgactgg gccatcgccc ttaactgatt tagcagcgtg
    18181 ttggataatg ccttccgtca agtccatgat gtcttggaag tctgcataag cttggtaaac
    18241 ttcgatagaa gtaaactcag ggttatgagt agcgtccatt ccttcgttac ggaagatacg
    18301 gccaatttca tagacacgtt ccataccacc cacgataagg cgttttaagt gaagctcagt
    18361 cgcgatacga agcaccatgt caatgttttg ggcattgtgg tgggtgataa atggacgggc
    18421 agcagcacca ccggcttcat tatgaagaac aggtgtttcc acttcaagga atcctttttg
    18481 gtcaaggtaa cgacggattt cagagatgat ttttgaacga gtgacaaagc gttcaaagct
    18541 ttcacggtta gaaatcaagt caaggtaacg tttacggtaa attgtttcaa cgtctgtcaa
    18601 accatggaat ttctcaggaa gaggacgaag agccttagac aagtgtgtga tgtgggttgc
    18661 cttgatagag agttctccca tatccgtacg catcacttca ccttcgacac caaggaagtc
    18721 accaaggtct gcttttttga agatttcgta gttttcttca ccgacagcat ccttacgaac
    18781 gtagatctga atctggcctt cgcggtcttg aaggtgggca aaaccaactt ttcctttacc
    18841 acgtttggtt accaagcgtc ctgcgatagt agctgtttcg tttttatcgt gtaattgttc
    18901 tttatcgagg ttggcatatt tatcttttaa ttcttgtgaa tttgcagtac gttcaaaacg
    18961 ttttccgaaa ggatcgattc cttgttcgcg gagcgcagcc attttttcac ggcgaacgat
    19021 ctgctggtca tttagttctt ccatatgttc tgtagacatg ggatcctcct aattttactc
    19081 aaaattgaat acgatgagtc attttttgcg atacccccat tttatcataa ataagcaaga
    19141 aattcacgga taatctttaa aaactaaaaa gaacctgacg ctaaaatcac tggaaagaag
    19201 tgaaagtatc tcccgcccca ctagcgatat agccaaatgc tgctttagga ataacttgtt
    19261 gcgccattgg ctccaaatca taggtattga tgaaatctac atgaccttct gcattgcttg
    19321 ttttgtatga cataaaatgt cctccttaat aagtaagcgt ttactttgta tattataaaa
    19381 atatcttaac tcttttttca aaacttttca aatattttgt ttggaaattt cagaaatttt
    19441 atgtctatgg taaaaaatcc ttataacggc aataaaaaat agatattatc caaagaagat
    19501 tttaagtgct acaataactg tattatttct agatgggagg ttctattttt ggattggtcc
    19561 attgttgaac aatatctacc actatatcaa aaggcattct ttctgacctt gcatattgca
    19621 gtttggggaa ttttgggatc ctttctgctc ggtttaatcg ttagtatcat ccgacattat
    19681 cgaatccctg ttttggcgca agtagcgaca gcctacattg aattgtcacg taatacgccc
    19741 cttttgattc aactcttctt tctctacttc ggtcttcccc gaatcgggat tgtcctatct
    19801 tcagaagtct gtgcaacgct tgggcttgtc tttttaggag gctcctatat ggcagaatct
    19861 ttccgaagtg ggctggaagc catcagtcaa acccagcagg agattggcct cgctattggt
    19921 ctgacacctc tacaggtctt tcgctatgtg gttcttccgc aagcaacagc ggtggcactc
    19981 ccctccttta gtgccaatgt cattttcctt atcaaggaaa cctctgtttt ctcagcagtg
    20041 gctttggccg acctcatgta cgtcgccaag gattttattg gtctctacta tgagacagac
    20101 attgcgctag ctatgttggt agttgcttat ctgatcatac tgctacccat ctcactggtc
    20161 tttagctgga tagaaaggag gctccgccat gcaggattcg ggaatccaag tactctttca
    20221 gggaaataat ctcctgagaa tcttacaggg attgggcgtt acgattgaga tatccatcct
    20281 gtctgtcctc ttatccatga tgttcggaac agtcatggga atcatcatga cctcccattc
    20341 tagaatcata cgatttttaa cacgattgta tctggacttt acccgtatca tgccccagct
    20401 ggtgctactc ttcatcgttt actttggctt agctcgaaac tttaatatca atatctcagg
    20461 tgagacttca gctattatcg tttttaccct ctggggagca gctgaaatgg gagacttggt
    20521 acgtggagct atcacttctc tccctaaaca tcagtttgaa agtggacagg cactcggctt
    20581 gactaatgtt caactttact accacatcat catcccacaa gtcttaagaa gactgctacc
    20641 gcaggctatc aatcttgtca ctcggatgat taaaaccact tcattagtta ttttgattgg
    20701 ggttgtggaa gtgaccaaag ttggacaaca aatcatcgat agcaatcgcc tgaccatccc
    20761 aactgcttca ttttggattt atggaaccat tctagtctta tatttcgcag tttgctaccc
    20821 tatttccaaa ctatccactc acttagaaaa acattggaga aactaaatgt ctgaaactat
    20881 cttagaaatc aaggaactaa aaaaatcctt cggagacaat cccatcctcc aaggactttc
    20941 tctagaaatc aaaaaaggga agttgttgtc atcctagggc cctctggttg tgggaaaagt
    21001 accctccttc gttgcctcaa cggcttagaa agtattcaag gtggagatat ttttctggat
    21061 ggtcagtcta tcgttgaaaa taaaaaagat tttcacctag ttcgccaaaa gattggcatg
    21121 gtctttcaaa gttatgaact ctttccccat ctggatgtct tacaaaacct catcctaggc
    21181 cctatcaaaa ctcaaggaag ggacaagaaa gaagtaacgg aagaagcttt gcaattacta
    21241 gatcgtgtcg gtttgctgga taaacaacat agctttgccc gtcaattatc tggtggacag
    21301 aagcaacgtg ttgcaattgt ccgtgccctc ctaatgcatc cagaaatcat cctttttgac
    21361 gaggtgactg cttcgctgga tccagaaatg gtgcgtgagg tgctggaact tatcaatgat
    21421 ttggtccaag aaggccgtac catgatttta gtaacccacg aaatgcagtt tgcccaagcc
    21481 attgctgacc ggattatctt cctcgaccaa gggaaaatcg ctgaagaagg aacagctcaa
    21541 gccttcttta ccaatccgca aaccaaacga gcccaggaat ttttaaacgt ctttgacttt
    21601 agccaattcg gctcatatct ataaaggaga ttcttatgaa actattcaaa ccactcttaa
    21661 ctgttttagc acttgccttt gcccttatct ttatcactgc ttgtagctca ggtggaaacg
    21721 ctggtccatc ctctggaaaa acaactgcca aagctcgcac tatcgatgaa aacaaaaaaa
    21781 gcggtgaact gcgaatcgcc gtgtttggag ataaaaaacc gtttgactac gttgacaatg
    21841 atggttctta ccaaggctac gatattgaac taggaaacca actagctcaa gaccttggtg
    21901 tcaaggttaa atacatttca gtcgatgctg ccaaccgtgc ggaatacttg atttcaaaca
    21961 aggtagatat tactcttgct aactttacag taactgacga acgtaagaaa caagttgatt
    22021 ttgcccttcc atatatgaaa gtttctctgg gtgtcgtatc acctaagact ggtctcatta
    22081 cagacgtcaa acaacttgaa ggtaaaacct taattgtcac aaaaggaacg actgctgaga
    22141 cttattttga aaagaatcat ccagaaatca aactccaaaa atacgaccaa tacagtgact
    22201 cttaccaagc tcttcttgac ggacgtggag atgccttttc aactgacaat acggaagttc
    22261 tagcttgggc acttgaaaat aaaggatttg aagtaggaat tacttccctc ggtgatcccg
    22321 ataccattgc ggcagcagtt caaaaaggca accaagaatt gctagacttc atcaataaag
    22381 atattgaaaa attaggcaag gaaaacttct tccacaaggc ctatgaaaaa acacttcacc
    22441 caacctacgg tgacgctgct aaagcagatg acctggttgt tgaaggtggc cattaactct
    22501 taaaagggac tggattttaa gctccaatcc ctttttaaga ttttacctat aacatcctga
    22561 gtctatctaa gatgttcaat ctgaacacag tgtacatact ttatcttcta ttgcatatac
    22621 tttatcacat aagatacgaa tatcctcttc actatgacta gcaatcaaaa ttgttgtccc
    22681 tttttcacta gagagctttc taaacaatgt tctcatattt tctacacttg atttatccaa
    22741 ggcattcata ggttcatcta gtaaaagaat agagggattc tccataattg cttgagcaat
    22801 ccctagcttt ttcctcatac ctagcgaata agttttaact ttctggtctt tttgctcata
    22861 tagaccaact attttcagtg tatcattgat ttcctgatta ccaactactc ctcgtatgct
    22921 tgccaaatat tgtaaattct taaagccact ataataattt ataaaaccag gttcttcaat
    22981 caaagctccc aaattagttg gaatttttct ctcaggaaca atattttccc cattgattaa
    23041 cacttctcca taagacggac tatataaacc agctattaat ttaaacaata cacttttccc
    23101 tgagccattc gcaccagtaa ttcctataat ttccccctgt ttacaactaa agttaaggtt
    23161 ttgaaaaaca catgtctttt ttaatttcaa ctcaatattt tttaatgtaa ttatttcatt
    23221 cattctataa acctcctctt ttgacgagtg aaatagaaaa tgctttgaaa aagaaagact
    23281 aaaaatagca actgaagaaa taaatctcgt cctatatctc cattccctcg attcaaaata
    23341 taaaatagat aattagttcg atttcctaca aatagaccac caaacacaat catgagtaaa
    23401 aagaaactaa cgcaagcaaa gttcatttgt acattcgctc ctagtgcgta taacataaag
    23461 caaaacaaga ctaacacaca agcattcaaa gaatcaacta taaacaaaac tcctatatcc
    23521 cagtttggta actgtaacat aaattgaatc actagaactt ttaccatgat taaaatgagt
    23581 ccataaagaa aacaggtcca aatctgatac ctaatccaga gcttaataga agaaaatcga
    23641 atcacttcca taaagaaatc ggatgctctt ctacgatata caactgctag aaaaaatgta
    23701 tgaataataa accaatgaag caaccatata gataagacta aaaaagagtt ttgactcaga
    23761 ttaggccctt ttaaaatttc tataacaagt ctatcatttc cttctaacca ataccataat
    23821 cctaaacaaa tcaatatcca aaaaagaaca taaccccaaa agtacttggt atagattatc
    23881 tgattcaacc tccacatgtg actacttaac tttcccattt ccaactttta cactctcctc
    23941 cagtttctat gaacagaaaa tacagtcaat ggaattatga tagatagtaa tgtaagccaa
    24001 taaatcaatg catacggatt ggaatttacc atatactgaa aaattggcaa taatccaatt
    24061 atcccattgt ccaactgata aatccagaat aaggattcta caaataaaaa agtaaacaga
    24121 aatactaagc tcatgtttga ttttttaaac caagaaaaac tgctaatagt aagtaaggat
    24181 aaaaagaaat agtatgctat ataagagaaa aaaaatccta taaagaaact agcattgttt
    24241 gcaatactta taccataaaa ttctcttaaa aaatcaacct cctttatctc caaagagaag
    24301 ctaaaaccat tactaaatgc aatcagaaaa atcaataaaa ataaagtcgc cgtccaaatc
    24361 cccgtactaa gagctgctaa tttgaaacta aaactggtaa agtgcttaat tgatttcaga
    24421 cgaatacgac actccaacct attaaaatag ttattcatca aataaaaaaa gaataatata
    24481 tatgtgaacg gaaagcaata tactccagtc gtcatatctt gaagtaaaac taagatccat
    24541 tctaatacat ttggatggat tgaatattgg cgacagcgca ataaatatac tgtactagat
    24601 aaaacacagg atagcagtaa tataaaataa accaatactg ctaagaaatc ttttttataa
    24661 aattgaacaa attgtttcat tatacatagt cctctgaatg tagaaaaaat gtaccataaa
    24721 caaccaaaca actaacaaat aaaataaaag caagatgccc actaactaag gaaagactga
    24781 tatctttctg atatcccaaa gctagcgttg tcacaggttc taagtaagat agccctaaaa
    24841 tagcccaaaa aataccacca accatcatat aggcaactgg gatgaaaata gctcctattt
    24901 ttttcttcac tagcaaagca ctagctagtc caaaaataga gaacacagcg ccccaaactc
    24961 cataccagag agtcgttaca agaccataga gaaactgatt ggaatcaaat aattctttta
    25021 aggcaccact ataatctcca atataaattt cctgataagg agtcactaaa agattaattc
    25081 ctaataataa taaatagggg agaaaaaaga ctagaaaaga agaaataatt gcagtactac
    25141 ctacaatagc tagatacctc tttttagaaa ttcggcacaa ttgtgctgtt agaaaatgac
    25201 tctcagcatc ctctattatc tgactagaat agggcagtgt acagataagt gcagctacta
    25261 ggctaatcgg tgaaaatcct cgaatagaag aagcggcaaa aaaaatcgat aaaccttcaa
    25321 ttttataaat accattgaaa gcaaggaaat ttcctaaact catgcaaaga agggtcaaaa
    25381 ataaagacat ataaaatcga ggtgattgaa cgactcgtac aagattacaa atgaaaaatt
    25441 ccatccttac tcctccttat aataaaaata gggtgtagca ttcttttttc atgctacacc
    25501 cacaatcaac catctttaag gcttactctg acaagtaagt taataagaat ctggactcca
    25561 agaacctgaa gtatgaattc ttacatgatt tccaaattgt ggcgccatag ctaatctagt
    25621 accagaacca atataattgt caccacctcc attatagtac atgacaatcc tagagccaga
    25681 ccccaatgaa tataccgggg taatatctga cccactatag gcgctacgaa tagaggtatt
    25741 taacctttta ccgccaccag tgctgtcact attattaatt ccagcagagg cgttttcttt
    25801 ctcaagctca ctagttgtat ccgaacccca acgcggcaac gttaaatcat aatttccaat
    25861 ctgtctagct aaaactgtag ggagaaacaa actagatgca attgtaacta cgcaaaaaag
    25921 gaatatattt ttcttctttt catgacatcg tcctcttaag aagtgataaa caagatagtt
    25981 gattgatcaa tttgatacat attacatttt cattatatca ataaaagaaa gcgttgtcaa
    26041 ttattttatt taaaatattg tcatatttta aataaaatgg taaaagagac tcggtagcct
    26101 cgtctctctt tatcttactg acctaacctt cttgccaatt ttcttggtct tctttaaagc
    26161 gttttagaag atcaaggccc tctggcgtga tgtaaccttc ttcttgggct agatggataa
    26221 gctcgctata gtttgaaagc gtcacaagtt taacaccagc atctgcaaag ttcttatctg
    26281 cttttggcaa ttggtagctg aaaatcgcta caactccaag cacatctgct ccttctcgct
    26341 tggctgctgc tacagcttca agaactgaac cacccgttga aataaggtct tcaaccacta
    26401 ccattttttg accttgagct acgcgacctt cgatttgatt accagctcca tggtcttttg
    26461 gtttgctacg gatgtaggca aaaggcaagt ccatcttatc agcaataatg gctccgtgtg
    26521 gaatccctgc tgttgcagtt cctgcaatca cttctacttc aggaaaggct tctttgatag
    26581 cttccacaaa accattttca attagggtac gagtttctgg ataggctagt gtcacacgat
    26641 tatcagtgta aatcggtgac ttgataccag atgcccaagt gaagggttcc tctggtttga
    26701 ggtaaacgga ttggattttc aagaggtggc tagcgatatc tttagcaagt gtcatggtat
    26761 tctcctttta tttttctaat ctagttcttt aattccagtc ctgtgtccat tcatccttga
    26821 tggcatgata agctgcaaca ggatcctcag cttgggtaat gggacgtccc actacgatat
    26881 agtcactgcc gatttgatag gcatcagcag gtgtcatgac tcgtttttga tctccaactg
    26941 caacaccagc tggacgaatc cctggtgtca gacagataaa atctggattg gtagcctgct
    27001 tgatgacttg tacttcctga gccgagcaaa caacaccatc caagccagct tcagctgtct
    27061 tcttggcata gtgaatcaca gactcttgca gactggtttg gatattttga aactcctgca
    27121 tctgagcttc tgacgttgat gtgagctgcg ttacagcgat caatttggct tgacttccaa
    27181 gaccttcacg cgcagccttc atcatctcta caccaccagc cgcatgaata ttggtcatat
    27241 ccacaccaag ctgagatagg atcttcattg ctgacttgac tgtattagga atgtcatgaa
    27301 gtttgagatc caaaaagaca ctgtgaccca gggctttcaa ataagacaca atctcaggcc
    27361 ccgctgcgta ataaagctcc atccctacct tgagataaag gctttcttct gctgggaaaa
    27421 gagctaaaaa ttccttgacc gcctcaaaac taggaaaatc aagagcaatg actggacgat
    27481 gttctcgcat aggtttctcc ttttaccttt actagtgaga gagtctggcc aacagaagcc
    27541 acgaaaaaag gaacctgcca acagcaaggt tccacgaaaa atgggtagtc tccacccttt
    27601 caccgtctaa ccttagctgc ctctctggac tgctttaaag gttttctatt attctattat
    27661 ttctactagc acttgtcaag taaaaactta gtcactaaag aactataaga gaaaaggtaa
    27721 acctagcgac gcgatgagcg ctgggtcgtt tgatttcgat tgctctcttc ctcttgtttt
    27781 ttctgttctt cttcctgttt tttctcagct tccttggcct cttgtttggc tttttcctca
    27841 gcctccataa ttaatttatc cgccacagtg taactgtaaa ttccagcttc catgtcaatc
    27901 acactcggtt ctgacaattg tggcttaatc ttactgtaat atggcagttt cttactcatt
    27961 tcagatagag gaaccaagac ttcgtccgaa tcattcatgg tcaatcgaat taaatcggat
    28021 gtcaccttgc ttggggctaa ttccaccttt tggatagccg ccttgagttc tgggctaatt
    28081 tgagcaagtt ctgagacaaa aaccttgatt tgttcactat cattaaagag aactgataaa
    28141 taagtttctg gtaaactgtt cagactcaca gaactagtct caagctgacc actggaaaga
    28201 ataggataat gattttcacc agaaatatag taggccacaa tatcatattc cttgacctta
    28261 atagtgaact tagttggaaa ttgatagaca agttgagcta attcaaccca atagttagac
    28321 ttaatctgct tttcatattt tgccttgtct agcagaaggt taatcgtata atccgaatcc
    28381 tgaatgcctg aagcctgtcg aatatcatca gctgtagttt gcaccgttcc ctcaacacga
    28441 atatctttca tggtcgcata aggactgagc aagtaggcag agacaatcaa taaaagcaga
    28501 cttggaaata aaatcgtgaa ggctcgcaag atatggatac caggaatctt tgctttggct
    28561 ggtttttcct ttgtagcctt tttagaaagc tttttatcct gttcctcctt ctctttagac
    28621 tctggttctt ctttctcttc tttctctttg tcagcctctg aggatgctac tttttcttca
    28681 gactcttcct tagctgattc tgaatcttcc tggtctgttt cactctcctg gtcctgtttg
    28741 tcctctgact tctcagattc ttctcccatt cgagcttgtc tttccttttc cttctcctca
    28801 gctagagccg cctcttcttc agccttcttt tttagatatt cttggtttcg tttctgccat
    28861 tctgataact ctttcaattc ttcgaggatt tctttgtcct catttttctt atcttttgac
    28921 atttactttc cttatgataa atcttttttc aacaattgat aaaaatctgc tagagatttc
    28981 aattccgtag aagccttcat cttagcttgg taatcttcct tgtgacttag taagtgagaa
    29041 agcttctctt ccaaactatc caaggtcaaa tcgctttctt gaaggtcttc tgcatagcct
    29101 ttttttacaa agtaagctgc attttcaatc tggtcaccac gactagcttc acgaccaagc
    29161 ggcacaatga catgcaattt tgctatcgcc aagagctcaa aaatcgtatt ggcaccacct
    29221 cgtgtcacaa caatatcagc caattccatc aagggttgat agagatcggt cacatagtca
    29281 acacgaaaaa gattttggct caactcattc aggctagaat ctccagttag attgataata
    29341 ttgtagcgct ctgttagttc tttcttatgg tctgtcacca attggttaaa gacacgagca
    29401 cctgcagaac cgccaacaaa caatacagtc ggcaatttat gattaaaatg gctttgaata
    29461 tccaccaatt catctggttc tggatttttt tgatctgaaa ccttggtcac tgctcccaca
    29521 tgctcaacct tagacaaact cgaagcttgc tcaaaggttg aatacatctt agtcgcaaat
    29581 ttataggcga ttttattggc caagcccata gacaggtcag attcgtgaat aaagacaggc
    29641 actcctgaca cacgcgcagc gataacaggc ggtactgaga caaagccccc ctttgaaaaa
    29701 agggtctgtg gacgaagtcg caacatgata aagagcgatt ggacgattcc ccagccaact
    29761 ttgaagacgt ccagcatatt ttgccaagag aaatagcgac gcaattttcc agtcgcaata
    29821 gaatggaagg tgacatccaa acctgactta aggatttctt ggtgttcgat accacgcttg
    29881 tccccgatat agtggacttc ccaaccatct tcgatgaact tgggcattaa caaaagattg
    29941 agggtaacgt gtccaaccgt ccccccacct gtaaagacaa tttttttcat attattcttt
    30001 taactccgct actgtgtcga taaagaggtc gccacgtact tcaaagttag catacatatc
    30061 ccagctggca ttggcaggac taagaagaac cacatctcct tgagtcgcaa gctcataggc
    30121 cttgcgggtc gcatctgcaa tatctgtcgc ctccacataa gcgacaccag ccttgtctgc
    30181 tgcccgtttg acacgttctg cagattgacc caggatgacc atcttcttga gtccagtaat
    30241 gtctggcacc aattcgtcaa actcattgcc acggtccaaa ccacctgcaa tcaagacgac
    30301 cttgctgtta tcaaatcctg acaaggcttt ttgagtagcc aagatattag ttgatttact
    30361 gtcgttatag aatttaacac ccttgatgtc atccacaaac tggagacggt gtttgacacc
    30421 accgaaggct gaaagagttt ccttgatggt ttgattgtcc acaccacgaa gcttggctac
    30481 agcaatagtc gcaagggcat tttccacatt gtggctacct ggaacaccga tttcattcgc
    30541 tgccatgact acttcaccac ggaagtagag ttgaccatct tccagataag ctccatcaac
    30601 cttttcaagt gttgaaaatg gtacaacagt ggcttctgtc ttggaagtca agtcttttgc
    30661 caagtcttga ttaaagttca agacaaggaa atcagctgct gtcatcttgt tctggatatt
    30721 ccacttggct gctacatatt ccgaaaatga cccatggtag tcgatatgag ttggcatgag
    30781 gttggtaata accgcaatct ctggatggaa ttcttgaaca cccatgagtt ggaaagaaga
    30841 aagttccata acaagcgtgt ccttatctga tgctatttga gcaacctgac tagctggata
    30901 gccgatattc cctgataaaa gaccatgttg cccagcagca gtcaaaactt ccccaatcat
    30961 agtcgttgtg gttgtcttac cgttcgatcc tgtgatacca ataatcggtg cttctgaaat
    31021 caaataagcc aattccacct cagtcaagac tggaattccc ttggccaaag ccttttcaat
    31081 catgggattg ttgtagggga tacctggatt tttcaccata agggcaaact cttcatccaa
    31141 gagttccaaa ggatggccac ctgtaatgac cttgatccct tcttccagca aactttgggc
    31201 agctggattg tcctcgaaag gcttcccatc atttactgtc acaatggcac ctaacttgtc
    31261 caacaaacga gccgcagatt caccagactt ggccaaacct aaaacaagga ctttcttatt
    31321 tttaaattga tctattactt tcatgtctcg aactccattt ctactcctac tattttacca
    31381 tttttatgga aataaaaaag ccacaaagtg tgtttgtgac tctttcttct aactgaatct
    31441 taccatatca tctatgtgat aaatcggtaa ctcgaatgac ctgatccact tgctcccaaa
    31501 tcagaggatt gtgggtcgca ataataatgg tccgattcgg attttttaaa gattctagga
    31561 tggaaagtaa ttcctcagag tttttggggt ctaaggaagc ggttggttca tctgcgagga
    31621 tcaaaggtgg atcctttaaa attatcttcg ctaatgcaac acgttgtgct tctcctcctg
    31681 ataactcaaa tataggttgc ttcaaatcca aataagagag gtttacacgg tttagagctt
    31741 gtttcatcaa agagattttc tctttttcct tcaacttttt accaactaaa cccagattga
    31801 gattctcttt gacggtttgg ctttcaatta agccaaaatc ttgaaataag tatcccaagt
    31861 aatctctaaa gaaaacagaa ggcttgatgt ccttaagaga agtaccatca tagatgattt
    31921 gtcctttgtc atatggctct aatcgtccaa tcatattcaa gagtgttgtc ttaccacagc
    31981 cacttgtacc gattaaggca taaattttcc caccttcaaa atgaagattc gtatctgaaa
    32041 atagctgacg gcttccaaat tttttagata tattctttag ttcaatcatc ctattttcct
    32101 ttcataattg tcatagaaac acgagattct ttctgcgctt gacggtaaag cgtcaaaact
    32161 gcactagcta gaaagacgaa taaagtgagc aagccaatca ccaagtctcg actgcttaaa
    32221 ataaagaaac tagcaccaaa tacaaaactg gcaaattggc taaccatata ctgagcatgt
    32281 gtttcaaaaa atcgtaaacc tgaaattcgt ttaatcaaga tatctcggcg gaattgctcg
    32341 aaatatagaa gattgacaga ataaaagagt aataaggaac tggctatccc aacaatagct
    32401 cctaagatta aagttgctgt ttcagtttga acttcattat aacgagttag ataaacactt
    32461 cttccttctt taagatagga tacttgctca taaattccag ctttctttaa gagttctagc
    32521 ccactctcat atcctttgat aaagagttgt tttccagcat tgatagacca aacatatttt
    32581 gaaatgaaac tatcacctgt agatgttgga gtaaatacaa ctaaaatcgg atcggttaag
    32641 tactgaatag atactggact ttcaccgtta ttataaacaa agcgtttttg tcctgttgga
    32701 agatagctaa caatcgctct catttcatac tctaaaggag cgtctttatc ctcgcttgat
    32761 tttccgtaat agttcaaacg ttcttcaaaa actttcttaa gttctgcttc ctgtgaacga
    32821 agagattctg gtaataagag tccaaattcc cctttttgaa gatgagctag tttctgtcta
    32881 gtctcatcat ttacagccac attttccttg tctaaataac ttggactcac atagagaaca
    32941 ttagcatctg gactataggt atccagtgtt tccccgtttt cattttttcc ttgaggattt
    33001 gcaaaatgaa tgagattctc ttttacaaat agagcctgtt ctttttcaac tgcttctttg
    33061 gaaaattcat accacttatt ctgattttct gtatcattta ctctgtcacc taagccaaaa
    33121 gaaatttgat aatagtctac tctgtcatgc catgcttgtt ttgaaatttc aagttctttc
    33181 aatcgttggt aagacgtcaa acctgtctta acagcgtatc ccactgtaaa gacagcaacc
    33241 aactgacaca atagggttaa aatcatcagg cgtttaaggg gtaatcttcc cttaataacg
    33301 ggaactaatg ctttgtaact caaactcatt agataaagga gcattagtaa aattgaaatc
    33361 gccaataaaa acaacagata gaaactaatc ccaaaaccat aggtggctaa caagatagga
    33421 taaaacaaac cttgactaaa aagaacgact cccccaccta ggaaggaaag gagggctgat
    33481 agaaggagcc acttaatatc agtagataaa gaatgcccca taatggataa gagagtctga
    33541 ccagaaaaga gttttatacc tgctgctctc atttccttaa tccgagtgat aatcactaaa
    33601 gcaaagaaag ataagccaaa tattgctaaa ctaattaaaa taaggggatt tagtaacatt
    33661 cgaaaagcaa gagaataggg aggtgtcttt cggtcagcaa ttgctttata acctaaatct
    33721 cctaatttat cagctagctt ttcttttgtc aaggagcctg ataaaaggag ataactattt
    33781 agcggatcac tacgttcacg actttcttgg ctagcttctt ggaattgttt tggtaatgtt
    33841 ccctgaccat aagttgcata agtaaagtga gtcgtcccat ccttactcgg ttctacaatt
    33901 ctcctagcta ttaaactctg ttctgagttt acaaacttct ccaattcctg ttcaaatacc
    33961 tcacgagtcg gttcctgagc ctcttttttg acacgaagta aagtaacgga atcatagctt
    34021 gcatataaat attgtggcgc acgtaagaca ataatccaag caaagaagaa gctgagaaaa
    34081 aaagttgata gtaatatgaa tagtttcttc atagtagact ccttgtaaac aaaattcccc
    34141 ctgtaatttc ttacaagggg aattatctaa gaaaactaaa tattagtcat agtcatagta
    34201 aaatgatact tgttccccaa atttagtcca aatccaagcc tctgaagttt tccctgcagg
    34261 tgctgatcct ttatctgaat gactatccca tttacttaca acagaagaat aatgatattt
    34321 tttaccatga tagtaatttg aaaaagccca accacctcct gaaccttctc catatgtcca
    34381 tactcctcca tctggatatt gtacagcagc tgatgcagct cccaataatg taaagcttga
    34441 aataagagct agagcaagta atctatgttt tttcgttttc attttatttt tcctttcaaa
    34501 aaaagcacac cctgagcaac aatgcaacaa aataaatcct cctctctctt ttttgaaacc
    34561 gatttcttat ataataagaa tagcattttt attatttgtt gtcaaggaaa aaatcgaatt
    34621 ttttagatgt tttacta
//
LOCUS       DAVHSO010000017        34346 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.017, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000017 DAVHSO010000000
VERSION     DAVHSO010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34346)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34346)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34346
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.017"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..135
                     /locus_tag="VVR18_000792"
                     /pseudo
     CDS             1..135
                     /locus_tag="VVR18_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436461.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(304..856)
                     /locus_tag="VVR18_000793"
                     /pseudo
     CDS             complement(304..856)
                     /locus_tag="VVR18_000793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007897432.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(932..1372)
                     /locus_tag="VVR18_000794"
                     /pseudo
     CDS             complement(932..1372)
                     /locus_tag="VVR18_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841825.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1363..1671
                     /locus_tag="VVR18_000795"
                     /pseudo
     CDS             1363..1671
                     /locus_tag="VVR18_000795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(1826..2149)
                     /gene="tnpB"
                     /locus_tag="VVR18_000796"
     CDS             complement(1826..2149)
                     /gene="tnpB"
                     /locus_tag="VVR18_000796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HEU6032356.1"
                     /translation="MTIHLSSLGQVYLVCGKTDMRQGIDSLAYLVKTHFELDSFSGQV
                     FLFCGGRKDRFKVLYWDGQGFWLLYKRFENGKLTWLSTEKDVKALAPEQVDWLMKGFS
                     ITPKI"
     gene            complement(2130..2315)
                     /locus_tag="VVR18_000797"
     CDS             complement(2130..2315)
                     /locus_tag="VVR18_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136123.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032357.1"
                     /translation="MPQPIVPVEIPQSRLFDSKKRNDILLKIRIGKLEVSFFQSLNLE
                     MVEQLLDKVLLYDNSSI"
     gene            complement(2619..4181)
                     /gene="guaA"
                     /locus_tag="VVR18_000798"
     CDS             complement(2619..4181)
                     /gene="guaA"
                     /locus_tag="VVR18_000798"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HEU6032358.1"
                     /translation="MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHK
                     ISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGG
                     KVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
                     CPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKK
                     IRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLG
                     GKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGT
                     LYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHI
                     VWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVR
                     SVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYD
                     ITSKPPATVEWE"
     gene            4323..5021
                     /locus_tag="VVR18_000799"
     CDS             4323..5021
                     /locus_tag="VVR18_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000936186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU6032359.1"
                     /translation="MLPAYMKIHDQIKKDIDEYRWAIGERLPSERDLAEQFAVSRMTL
                     RQAVSLLVEEGVLERRVGSGTFVSSTRVQEKMRGTTSFTEIVKSQGKVPSSQLISYKK
                     TIPNEQEVAKLGIFPTDNIIRMERVRYADQVPLVYEVASIPEKFIKDFKKEEITSHFF
                     QTLQKHGYRIGKSQQTIYARLAKEKIAHYLEVEKGHAILGLTQVSYLEDGTAFEYVKS
                     QYVGERFEFYLENN"
     gene            complement(5064..5960)
                     /locus_tag="VVR18_000800"
     CDS             complement(5064..5960)
                     /locus_tag="VVR18_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HEU6032360.1"
                     /translation="MSNSLKGTLLTVVAGIAWGLSGTSGQYLMAHGISALVLTNLRLL
                     IAGGILMILTYATAKDKILVFLKDRKSLLSLLIFALIGLFLNQFAYLSAIQETNAGTA
                     TVLQYVCPVGILIYSCIKDRVAPTLGEIVSIIFAIGGTFLIATHGQLDQLSMTPAGLF
                     WGLFSALTYALYIILPIALIKKWGSSLVIGVGMVIAGLVALPFTGVLQADIPTSLDFL
                     LAFAGIILIGTVFAYTAFLKGASLIGPVKSSLLASIEPISAVFFAFLIMNEQFYPIDF
                     IGMAMILFAVTLISLKDLFLEK"
     gene            complement(5969..6904)
                     /locus_tag="VVR18_000801"
     CDS             complement(5969..6904)
                     /locus_tag="VVR18_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-lactamase family protein"
                     /protein_id="HEU6032361.1"
                     /translation="MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSDPEH
                     GLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLDIDRLVIDFLPESDYPDITIRQLL
                     THATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDL
                     DVILKDQVWKPWGMTETKFGPVELAVPTVRGVEAGIVHDPKARLLGRHAGSAGLFSTI
                     KDLQIFLEHYLADDFARDLNQNFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQK
                     QEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEE"
     gene            complement(6901..7626)
                     /locus_tag="VVR18_000802"
     CDS             complement(6901..7626)
                     /locus_tag="VVR18_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001102210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CppA family protein"
                     /protein_id="HEU6032362.1"
                     /translation="MNVNQIVRIIPTLKANNRKLNETFYIETLGMKALLEESAFLSLG
                     DQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVENPLEIEGILSKTDSIHRLYKGQN
                     GYAFEIFSPEDDLILIHAEDDRASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDI
                     ESFLESSEIGASLDFIPAQGQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFESTEYF
                     IPKSEKFFLCKDRNNVELWFEEV"
     gene            complement(7710..8345)
                     /locus_tag="VVR18_000803"
     CDS             complement(7710..8345)
                     /locus_tag="VVR18_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-alkyl-2-acetylglycerophosphocholine esterase"
                     /protein_id="HEU6032363.1"
                     /translation="MAVQLLENWLLKEQEKIQTKYRHLNHISVVEPNILFIGDSIVEY
                     YPLQELFGTSKTIVNRGIRGYQTGLLLENLDAHLYGGAVDKIFLLIGTNDIGKDVPVN
                     EALNNLEAIIQSVARDYPLTEIKLLSILPVNEGEKYQQAVYIRSNEKIQNWNQAYQEL
                     ASAYMQVEFVPVFDCLTDQAGQLKKEYTTDGLHLSIAGYQALSKALKDYLY"
     gene            complement(8347..9174)
                     /locus_tag="VVR18_000804"
     CDS             complement(8347..9174)
                     /locus_tag="VVR18_000804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU6032364.1"
                     /translation="MMIKVIATDMDGTLLDARGQLDLPRLEKILDQLDQRGIRFVIAT
                     GNEIHRMRQLLSPLVDRVVLVVANGARIFENNELIQAQTWDDAIVNKALAHFKGRACQ
                     DQFVVTGLKGDFVKEGTIFTDLESFMTPEMIEKFYQRMQFVDELTSDLFGGVLKMSMV
                     VGEERLSSVLEEINALFDGRVRAVSSGYGCIDILQAGIHKAWGLEELLKRWDLKSQEI
                     MAFGDSENDVEMLEMAGIAYAMENADEKAKAVATALAPANSQGGVYQVLENWLEKGE"
     gene            complement(9196..9532)
                     /locus_tag="VVR18_000805"
                     /pseudo
     CDS             complement(9196..9532)
                     /locus_tag="VVR18_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398793.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="poly-gamma-glutamate biosynthesis protein"
     gene            complement(9533..10261)
                     /locus_tag="VVR18_000806"
                     /pseudo
     CDS             complement(9533..10261)
                     /locus_tag="VVR18_000806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843873.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
     gene            10774..11385
                     /locus_tag="VVR18_000807"
     CDS             10774..11385
                     /locus_tag="VVR18_000807"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEU6032365.1"
                     /translation="MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEII
                     LGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEA
                     YDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
                     IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE"
     gene            11430..12158
                     /gene="rlmB"
                     /locus_tag="VVR18_000808"
     CDS             11430..12158
                     /gene="rlmB"
                     /locus_tag="VVR18_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HEU6032366.1"
                     /translation="MKTNDIVYGVHAVTEALLANTGNKLYLQEDLRGKNVEKVKELAT
                     EKKVSISWTSKKSLSEMTEGAVHQGFVLRVSEFAYSELDYILAKTRQEENPLLLILDG
                     LTDPHNLGSILRTADATNVSGVIIPKHRTVGVTPVVAKTATGAIEHVPIARVTNLSQT
                     LDKLKDEGFWTFGTDMNGTPCHKWNTKGKIALIIGNEGKGISSNIKKQVDEMITIPMN
                     GHVQSLNASVAAAILMYEVFRNRL"
     gene            complement(12197..13108)
                     /gene="trxB"
                     /locus_tag="VVR18_000809"
     CDS             complement(12197..13108)
                     /gene="trxB"
                     /locus_tag="VVR18_000809"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HEU6032367.1"
                     /translation="MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSD
                     IENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRT
                     VIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEALFLT
                     RFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKT
                     GQVTEQAFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDNHMKTAVDGIFAVGDVRLK
                     DLRQVTTAVGDGAIAGQEAYKFITEHS"
     gene            complement(13174..13398)
                     /locus_tag="VVR18_000810"
     CDS             complement(13174..13398)
                     /locus_tag="VVR18_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4059 family protein"
                     /protein_id="HEU6032368.1"
                     /translation="MLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTARARQ
                     AHLYDMIMIGVLVVPVLSFAVMSLILVFKA"
     gene            complement(13476..14219)
                     /locus_tag="VVR18_000811"
     CDS             complement(13476..14219)
                     /locus_tag="VVR18_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU6032369.1"
                     /translation="MIKISNLSKSFSGQTVLDHLDLDIQKGEVVALIGSSGAGKSTFL
                     RSLNYLETPDSGSIQIDGFSVDFSKITQEEILALRRKLSMVFQQFNLFERRTALDNVK
                     EGLVVVKKLSDQEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDV
                     LLLDEPTSALDPELVGEVEKSIADAAKSGQTMILVSHDMSFVAQVADKILFLDKGKII
                     ESGTPDEIIHTPKEERTKEFFASYKRTYI"
     gene            complement(14219..15019)
                     /locus_tag="VVR18_000812"
     CDS             complement(14219..15019)
                     /locus_tag="VVR18_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001103446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6032370.1"
                     /translation="MNVTTILASDWYQNLMQLIPDGKLFSLRSVFDGIPRIVQQLPTT
                     IMLTIGGALFGLVLALLFAIVKINRVKILYPLQAFFVSFLKGTPILVQLMLTYYGIPL
                     ALKALNQQWGTGLNINAIPAAAFAIVAFAFNEAAYASETIRAAILSVNPGEIEAARSL
                     GMTRAQVYRRVIIPNAAVVATPTLINSLIGLTKGTSLAFSAGVVEVFAQAQILGGADY
                     RYFERFISVALVYWVVNIGIESLGRFIERKMAISAPDTVQTDVKGDLR"
     gene            complement(15177..15533)
                     /locus_tag="VVR18_000813"
     CDS             complement(15177..15533)
                     /locus_tag="VVR18_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEU6032371.1"
                     /translation="MLEFIEYPKCSTCKKAKQELNQLGVDYKAVHIVEETPSQEVILN
                     WLETSGFELKQFFNTSGIKYRELGLKDKVGSLSNQEAAELLASDGMLLKRPILVENGT
                     VKQIGYRKSYEELGLK"
     gene            complement(15527..16057)
                     /locus_tag="VVR18_000814"
     CDS             complement(15527..16057)
                     /locus_tag="VVR18_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HEU6032372.1"
                     /translation="MQKKYVKILYSSPIGILSLVADDHYLYGIWVQEQKHFERGLGDE
                     TIEEVVSHPILDPVIACLDDYFKGKPQDLSNLLLAPIGTNFEKRVWDYLQGIPYGQTV
                     TYGQIAQDLQVASAQAIGGAVGRNPWSILVPCHRVLGAGKRLTGYAAGVEKKAWLLEH
                     EGVDFKDRNNRRRSTC"
     gene            complement(16057..16551)
                     /locus_tag="VVR18_000815"
     CDS             complement(16057..16551)
                     /locus_tag="VVR18_000815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032373.1"
                     /translation="MEIRLAFPNEVDAIMQVMEDAKKCLADAGSDQWQNGYPNADVII
                     DDIISGQAYVALEEGELLAYAAVTKSPEEAYEAIYEGNWQAGESEYLVFHRIAVAADV
                     QGKGVAQTFLEGLIEGFDYLDFRSDTHAENKVMQHIFEKLGFKQVGKVPVDGERLAYQ
                     KLKK"
     gene            16686..17132
                     /locus_tag="VVR18_000816"
     CDS             16686..17132
                     /locus_tag="VVR18_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HEU6032374.1"
                     /translation="MKTTFSYPKWAEIPNIDLYLDQVLLYVNQVCAPISPNKDKGLTA
                     SMVNNYVKNGYLTKPDKKKYQRQQIARLIAITTLKSVFSIQEIAQTLNTLQTQASSDQ
                     LYDAFVDYMNQGIDPANPIIQTSCQTVKLYHQTLDLIDHTQEEVIQ"
     gene            17129..17776
                     /locus_tag="VVR18_000817"
     CDS             17129..17776
                     /locus_tag="VVR18_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001097995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HEU6032375.1"
                     /translation="MNTSLKLSKQLSFGEEIANSVTHAVGAVIMLILLPISSIYSYEA
                     HGFLSSIGVSIFVISLFLMFLSSTIYHSMAYGSTHKYVLRIIDHSMIYVAIAGSYTPV
                     VLTLMNNWFGYLIIVIQWGTTIFGILYKIFAKKVNEKFSLALYLIMGWLVLVIIPAII
                     NQTTPVFWSLMVTGGLCYTVGAGFYAKKKPYFHMIWHLFILAASVLQYIAIVYYM"
     gene            complement(17797..18378)
                     /gene="pdxT"
                     /locus_tag="VVR18_000818"
     CDS             complement(17797..18378)
                     /gene="pdxT"
                     /locus_tag="VVR18_000818"
                     /EC_number="3.5.1.2"
                     /EC_number="4.3.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase glutaminase
                     subunit PdxT"
                     /protein_id="HEU6032376.1"
                     /translation="MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSG
                     LILPGGESTTMGKLLRDQNMLLPIREAILSGLPVFGTCAGLILLAKEITSQKESHLGT
                     MDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEILATVNNQIVA
                     AQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS"
     gene            complement(18379..19254)
                     /gene="pdxS"
                     /locus_tag="VVR18_000819"
     CDS             complement(18379..19254)
                     /gene="pdxS"
                     /locus_tag="VVR18_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012054698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase lyase subunit
                     PdxS"
                     /protein_id="HEU6032377.1"
                     /translation="MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMAL
                     ERIPADIRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYIDE
                     SEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGEPGTGDIVQAV
                     RHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHEHGKLPVVNFAAGGVATPA
                     DAALMMQLGAEGVFVGSGIFKSGDPVKRASAIVKAVTNFRNPQILAQISEDLGEAMVG
                     INENEIQILMAERGK"
     gene            complement(19406..20785)
                     /locus_tag="VVR18_000820"
     CDS             complement(19406..20785)
                     /locus_tag="VVR18_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HEU6032378.1"
                     /translation="MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGC
                     GMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKE
                     SYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
                     HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHN
                     IRLALGQTVKAIEGDGKVERLITDKESFDVDMVILAVGFRPNTALADGKIELFRNGAF
                     LVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGIVGAYNACGHELEGI
                     GVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIV
                     FDKDSREILGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYI
                     TMAALTAEK"
     gene            21079..22002
                     /locus_tag="VVR18_000821"
     CDS             21079..22002
                     /locus_tag="VVR18_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HEU6032379.1"
                     /translation="MTLRSHSERLMGTTITISLVDEQADIFLQKSFDLLKELEYRFNA
                     NSQESELMEINYQAGISPVTVHPDLFELISLGLEHSLALSSHLNISIGPLIQTWRIGF
                     SDAKVAQPQEIESVLPLINPHGIELDSSTSTVFLKQKGMKIDLGCLAKGYSADKVAQF
                     LRKEGVTSALINLGGNILTIGKNQARGDNPWQIGIQDPANPRGNHLMTIPVVNKSVVT
                     SGIYERHLTVDGQDYHHIFDSQTGYPVETELASLTIISDKSVDGEIWTTRLFGERPAS
                     ILWQVESLEGIEVILIDKEGHLSCSSGIPTL"
     gene            22062..22667
                     /locus_tag="VVR18_000822"
     CDS             22062..22667
                     /locus_tag="VVR18_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEU6032380.1"
                     /translation="MLKLIAIVGTNSKRSTNRQLLQYMQKHFADKAKIELVEIKAIPV
                     FNKPADKQVPAEILEIAAKIEEADGVIIGTPEYDHSIPAVLMSALAWLSYGIYPLLNK
                     PIMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDLD
                     VIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENL"
     gene            22686..23930
                     /locus_tag="VVR18_000823"
     CDS             22686..23930
                     /locus_tag="VVR18_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000673688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEU6032381.1"
                     /translation="MKFVGLVGSNYDQSYNRKLLEFIRRYFKLKFELEVLEIDEVPMF
                     NQDEKWDESFQLRYLYNKITRADGVIIATPEHNHTISASLKSVLEWLSYEVHPFENKP
                     VMIVGASYYDQGTSRAQVHLRKILDAPGVNAYTLPGNEFLLGKAKEAFDNNGNITNEG
                     TVKFLETCLDNFVKYVGVVSKLKKPKPIESEDLDCGKPIATTITEVDPDDPEWVEKVA
                     AITGAVSGDTYVKLDHGILTVNQIDMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMF
                     AKRVPPQSGSRMSTVHGSLPPARMKNVEWVIGTLRNGNQEYVRTIVPGSPAGVINTHN
                     YQAMYYPDGSYAGINEIVFNFQPWLDWYLKETGQRLMGGSGPFAPAAGGHGDADATSG
                     ASDSGDAGGHGGDADATAGASY"
     gene            complement(24047..24304)
                     /locus_tag="VVR18_000824"
     CDS             complement(24047..24304)
                     /locus_tag="VVR18_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002901318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 family protein"
                     /protein_id="HEU6032382.1"
                     /translation="MDPKKIARINELAKKKKTEGLTPEEKVEQAKLREEYIEGYRRAV
                     RHHIEGIKIVDEEGNDVTPEKLRQVQREKGLHGRSLDDPNS"
     gene            complement(24346..26382)
                     /locus_tag="VVR18_000825"
     CDS             complement(24346..26382)
                     /locus_tag="VVR18_000825"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HEU6032383.1"
                     /translation="MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKGKRLSFEAI
                     QTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVE
                     DIEFREIKGEEYVYVTKEEIGQAVEAIVPGIVDVLKSLTFPVSMHWAGNSFEYIRPVH
                     TLTVLLDEQEFDLDFLDIKGSRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCER
                     EQMIVDQIKEIEAKHDVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTS
                     MKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQ
                     KLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKADLSVDETVDLARAAAIY
                     KFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAV
                     LAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYA
                     LKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEV
                     SKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQ
                     LKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK"
     gene            complement(26642..27559)
                     /gene="glyQ"
                     /locus_tag="VVR18_000826"
     CDS             complement(26642..27559)
                     /gene="glyQ"
                     /locus_tag="VVR18_000826"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018163989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HEU6032384.1"
                     /translation="MSKKLTFQEIILTLQQFWNDQGCMLMQAYDNEKGAGTMSPYTFL
                     RAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEK
                     LGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATGPVTAE
                     VTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEISDQEMLLENFD
                     KFEKEAGRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVA
                     KTFVAERKRLGYPLLDEETRVKLLAEDAE"
     gene            complement(27927..28688)
                     /locus_tag="VVR18_000827"
     CDS             complement(27927..28688)
                     /locus_tag="VVR18_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEU6032385.1"
                     /translation="MDNLYLVKDDSQLATFRDFVVRNTEKLKDYQSFLKNELAVCDLP
                     QAVIWSDFNAATQIIRESAVPAYTNNRRMVMAPDLAVWKELYLYQLMDYECSQQTQAI
                     ESHYHSLSENFLLQIVGHELAHWSEHFLDDFDGYDSYIWFEEGMVEYISRKYFLTEEE
                     FQAEKICNQSLVELFQKKYGWHSLNDFGSSTYDKNYASIFYEYWRSFLTVDKLVENLG
                     SVQAVLDSYHLWANTEKTFPLLDWFVQQKLIEKEI"
     gene            complement(28961..29803)
                     /locus_tag="VVR18_000828"
     CDS             complement(28961..29803)
                     /locus_tag="VVR18_000828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HEU6032386.1"
                     /translation="MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHID
                     TAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLD
                     LYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA
                     TIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKS
                     IAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVD
                     DVDF"
     gene            complement(29917..31308)
                     /locus_tag="VVR18_000829"
     CDS             complement(29917..31308)
                     /locus_tag="VVR18_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HEU6032387.1"
                     /translation="MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQK
                     SFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKD
                     KLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKVEETEKTSLGKVHLTEDGQ
                     PFTLDQLFSDASKAKEQLIKELTSFIEDKKIEQDQSEQIVKNFSDQDLSAWNFDYKDS
                     QIILYPSPVVENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKYQKVVALTFDD
                     GPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILS
                     QLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDW
                     KSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNT
                     RLKAHELYYSRDE"
     gene            complement(31543..31920)
                     /locus_tag="VVR18_000830"
     CDS             complement(31543..31920)
                     /locus_tag="VVR18_000830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001833802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HEU6032388.1"
                     /translation="MICQFIRDMLDLPAKNVTILEGSNIHVLPSMPYSAQDFYTSIDV
                     LAELDNGIQVIIEIQVHHQNFFINRLWAYLCSQVNQNLEKIRQREGDTHQSYKQIAPV
                     YAIAIVDSNYFSDDLAFHSFIVK"
     gene            32153..33130
                     /locus_tag="VVR18_000831"
     CDS             32153..33130
                     /locus_tag="VVR18_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEU6032389.1"
                     /translation="MLKLGVIGTGAISHHFIEAAHTSEEYQLVAIYSRKLETAATFAS
                     RYQNIQLFDQLEVFFKSSFDLVYIASPNSLHFAQAKAALSAGKHVILEKPAVTQPQEW
                     FDLIQTAEKNNCFIFEAARNYHEKAFTTIKNFLADKQVLGADFNYAKYSSKMPDLLTG
                     QTPNVFSNRFAGGALMDLGIYPLYAAVRLFGKANDATYHAQQLDNSIDLNGDGLLFYP
                     DYQVHIKAGKNITSNLPCEIYTTDGTLTLNTIEHIRSAIFTDHQGNQVQLPIQQAPHT
                     MTEEVAAFAHMIQQPDLNLYQTWLYDAGSVHELLYTMRQTAGIRFEAEK"
     gene            33127..34209
                     /locus_tag="VVR18_000832"
     CDS             33127..34209
                     /locus_tag="VVR18_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU6032390.1"
                     /translation="MKTKLPTEWQELSDQLGFQEFTPIQTQLFEPLLAGENLLGVSQT
                     GTGKTLAYLLPSLLRLQKKKAQQLLILAPNTELAGQIFDVCKTWAEAIGLTAQLFLSG
                     SSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMNVETIILDEFDQLLDDSQIHFV
                     EKITHYAPRDHQLVYMSATTKFDQEKIVPNTRTIDLSDQKLDNIQHFYMQVDQRHRVD
                     MLRKLAHVEDFRGLVFFNSLSDLGNAEEKLQYRDILAVSLASDVNVKFRKIILEKFKD
                     NQLTLLLATDLLARGIDIDSLECVVNFDIPRDSETYTHRAGRTGRMGKEGYVITLVTH
                     PEEIKKLKKFASIREIVLKNQELYIK"
BASE COUNT        10214 a         7669 c         6177 g        10286 t
ORIGIN      
        1 aagaatcacc aaatccctcg tatcatcaac caaaaaattg cgcaaaagtt aattgaaaag
       61 aattctatga ccgatattgc ccatcagctg gccatttcaa cttcaactgt cattcgaaag
      121 ctcaatgact tccacgttta cgagagtttc ctcgtttgga agacattcta gaagatagga
      181 tagatatttc tcgctattta taatggattg aaataagata tgaacaaatc gattaggaaa
      241 ggaaaattga tttatagaaa tgttttagca gtcgatgcgt actgttatag attcaacgca
      301 ctataattga tgacgtttag ctgtttccaa caagctcata ataatagctc ttgctttagc
      361 tccttcaaaa ctttgagaaa ataaccaccc tcgctttttt aaactgagct caggctaaaa
      421 gagtccactg gactctttta ctccgtccca taaccaatga tttaatggcg cgttcagcta
      481 gattattgga aaggaccaga tgtccgtctt tcaaaatagt cttaaaggtt tcttcatact
      541 tgaggctgta ttcaattgcc cttcctagtt ttgaacctgc taaaactgac tgacggccgg
      601 caccaagcaa agaaatcttc cattaggttg gagctcttct tgacgtttct gtagtcgttc
      661 atcagctggc aatgtcctcc cagtctcttt ccaaggaaaa taactgatca caataggcta
      721 atcctttagc tcctaaggat gatttatctg cttgcttggg ggtcgcttca aaaaacttcc
      781 ttctcacatg tgcccaacat ccaacaagtt cagcttcttc cagttgacga taagcttcta
      841 gcggttcgca gtttaccaag cttagcgtcg ccttgctcct aaaccttgga ctgctatcgc
      901 ataggcagaa ctagaggact aaagtcctaa gttactgccg caacatatca caatgaacat
      961 agccagaata atctcctagg aattcttgta ctaccgaacc actccgactc tgatcatgat
     1021 ggtacagcgt gattgcttga ttctcaactt tcccagacaa aaaggttcaa tagtaggtca
     1081 gatggctatg actctctaga acccgataag aggtttcatc tgcatgaaga agagcttgtt
     1141 ctaacaactt ttctcgtaaa agattataaa ggggctccaa ataatagtga ctcgtcttga
     1201 tatgccaatt agaaatttcc ttacgtgtga ttggtaaacc catcttagcc caatcttctt
     1261 cttagcgata attgggtacc ttcagaataa acttctgatg gatggtgtga gcgataatag
     1321 aagctgagcc aaggctatgc gccaaagggg ctttaggaat aggagctttc acaagcttat
     1381 ccagatgatt atcttttact cgttatggac aatgctatat ggcataaatc aagtacctta
     1441 aagattccga ctaatattgg ctttgcattt attcctccat acacaccaga gatgaacccc
     1501 attgaacaag tgtggaaaga gattcgtaaa cgtggattta agaataaagc ctttcaaact
     1561 ttggaagatg tcatgaatca acttcaagat gttatacaag gactggagaa ggaggtgata
     1621 aagtccatcg ttaatcggag atggactaga atgcttttta aaatcagatg agtataaaaa
     1681 gaaagtcctc atttcaatag aaatcacgac tttctgatgg atttatagta aaatgaaata
     1741 agaacaggac aaatcgatca ggacaatcaa atcgatttct aacaatgttt tagaagcaga
     1801 ggtgtactat tctagtttca atctactata tttttggagt gatagaaaag cctttcatca
     1861 gccaatctac ttgttcaggt gcgagagctt tgacatcctt ttctgtactt agccaagtca
     1921 gttttccgtt ctcaaagcgt ttatatagta gccaaaatcc ttgaccatcc cagtaaagga
     1981 ctttaaagcg gtctttacgt ccaccacaaa agagaaaaac ttgacctgag aaagaatcca
     2041 attcaaagtg ggttttaacc agataagcca gtgaatcgat tccttgtctc atatccgttt
     2101 tcccacatac gagatagacc tgccctaggc tagatagatg aattgtcata gagcaacacc
     2161 ttatccaaaa gctgttctac catttcgaga ttgagagatt gaaaaaaact tacttcaagc
     2221 ttgccaatac gaattttaag cagaatatca tttctctttt tagaatcaaa aagacgagat
     2281 tgtggaatct ctacaggaac aataggttgt ggcattaaaa tatcctccaa tagttttact
     2341 ttactaatag tatacaggag gagctccatg aatgatagat accttgttat gacgcgctta
     2401 ctatattaga aagttggctc tctaattaaa ttaattctca ttatatatat caaaagaccg
     2461 cagcttgaaa actacggtct aattttttgt ccaaatgtaa accacttgga actattattc
     2521 aatttattct ttttagtaaa tgttcccgtt ttaatcccag ttacagtttt taatcctctg
     2581 taaccgttga ttttacaaag cttttaattt ttttgcgatt attcccactc aactgttgca
     2641 ggtggtttac ttgtaatatc gtagacgata cggttaacat gatccacttc atttacgata
     2701 cgtactgaga ttttttgaag tacttcccat ggaattttgg caaaatcagc agtcatacca
     2761 tcgatagaag tgatagcacg gattgcaatc gtgtagtcat acgtacgacc gtcacccata
     2821 acaccgactg aacgaacgcc tgtgttaaca gtgaagtatt gccaaatatc gcggtcaagt
     2881 ccagctttag cgatttcttc acgaagaata gcgtctgatt cacgaacggt ttcaagtttc
     2941 tcttcagtga tttcacccat gacacggata gcaagtcctg gtcctgggaa tggttggcgc
     3001 catacgatat ggtctggcat accaagctct gtaccaagag cacgaacttc atccttgtaa
     3061 agagtattga gtggttcaat caattcaaac tgcatatctt ctggaagacc acccacgttg
     3121 tggtgtgact tgatagtttg agctgtatcc gtaccagact cgataacatc tgtatataaa
     3181 gtaccttgag caaggaattt cacatctttg agcttgcttg cttcgtcatc gaatacatag
     3241 acaaactcgt taccgatgat tttacgtttt tgttcagggt cagaaacgcc agcaagtttg
     3301 tcaaggaaac gtttagcagc gtctgctttg acgatattca aaccaaactt accaccgagc
     3361 atgtccataa cttgatcagc ttcgccttta cgaagaagac cgtggtctac gaagatacag
     3421 atcaattgat cgccaatcgc tttttggaga agaaccccaa cgacagatga gtcaacacca
     3481 cctgatagac caagaaggac acgtttatca ccgacggttt cacgaatttt tttgatctgc
     3541 atgtcaatga aattatccat tgaccagtca cctttagcct tacaaatgtt aagggcaaag
     3601 ttacgaagga tatcatttcc gtatacagaa tgacgaactt ctgggtggaa ttggataccg
     3661 taaatgtgtt tatctgggtt ttcgatggct gcgtatgggc agtcagctga tgtacctgta
     3721 cgaacaaagt cagcaggaat ctcagtaacc gcatcaccat ggctcatcaa aacagtctgt
     3781 tcatcaggtg ttgattcaaa aagcgctgat ggtgtgtgtg ttagggttga ttgaccgtat
     3841 tcacgatttc cagcatcacc tgcaggaaca acttttcctc caagtttatg ggtcaataac
     3901 tgcataccat aacagattcc caaaattgga attccgagtt cgaagatttc tgggtcaata
     3961 tcaaatgaac catcttcata tacagaattt ggaccacctg atagaataat tcctacagga
     4021 ttgacttcac gaacttcagc agctgaaatt ttatggcttt ttagttctga aaaaacacca
     4081 atctcacgga tacggcgtga aatcagctgg ttgtactggc taccatagtc caatacgatg
     4141 attttttcta catcttgcaa atcagttgaa atgttgctca tctttttcct ttctcaaaag
     4201 aaatatcttt tcccaatatt ctatcacaaa taagggcgaa ttaccaacta aacaaggcga
     4261 agtttgactt tttctagttt attgaggtac aatagagaaa agatagaaat gaagtgaaaa
     4321 atatgctacc tgcttatatg aaaatccatg atcagataaa aaaggatatt gacgagtacc
     4381 gttgggctat tggtgagagg cttcccagtg aaagagatct agctgagcag tttgcggtca
     4441 gtcgcatgac cctccgccaa gccgtatctc tattagtcga agaaggcgtc ttagagcgcc
     4501 gtgtaggaag cggcaccttt gtttccagta ctcgagtaca agaaaagatg cgagggacaa
     4561 ccagttttac tgaaattgtc aaatcccaag gtaaagttcc ctctagccag ctcatttcct
     4621 acaaaaaaac cattcccaat gagcaagaag ttgccaagct aggaattttt ccaacggaca
     4681 atattatccg aatggagcgg gtccgctatg ccgaccaagt tcccctagtt tatgaagttg
     4741 cttctattcc tgaaaaattc attaaggact ttaaaaaaga agaaatcacc agtcatttct
     4801 tccaaacctt gcaaaaacat ggctatcgta tcggcaaatc tcaacagacc atctatgctc
     4861 gccttgctaa agaaaagatt gcccactatt tggaagttga aaaaggacat gctattcttg
     4921 gattgaccca ggtttcctac ctagaagatg gtactgcttt tgaatacgta aaaagtcaat
     4981 atgtaggcga acgctttgaa ttttatcttg aaaataatta gattaccacg caaaaactct
     5041 ctgtcacgga caaagagtct tttttatttt tctaagaata aatctttcaa agaaatcaaa
     5101 gttacagcaa acaatatcat tgccatacca ataaaatcaa tgggataaaa ttgttcattc
     5161 attattaaga aggcaaagaa aaccgccgat attggctcaa ttgaagccaa caagcttgac
     5221 ttgaccggtc ctatcagact ggctccttta aggaaagctg tataggcaaa gacagtcccg
     5281 ataaggataa tgcctgcaaa cgcaaggaga aaatcaagac tagtcgggat atcggcctgt
     5341 agaacccctg taaaaggaag ggcgaccaaa cctgctatga ccattcccac accaatgacc
     5401 aagctgctcc cccacttttt aatcaaggct atgggtaaaa tgatatacag agcataagtc
     5461 aaggcagaaa agagacccca gaacaggcca gcaggtgtca tggataactg gtccaactgc
     5521 ccatgtgttg cgatcaggaa ggttcctccg atggcgaata tgatggaaac tatctctccc
     5581 agtgtcggtg ccaccctatc cttgatacag ctataaatta aaattccgac aggacaaaca
     5641 tactgaagca ccgtcgctgt tcccgcattg gtctcctgaa tagcagacag ataggcgaat
     5701 tggttgagaa aaagaccaat cagagcaaaa ataagaagag acagcaaact ctttctatcc
     5761 tttaaaaaga ccagtatttt atcctttgca gtagcataag tcaagatcat gagaattcca
     5821 ccagcgatta aaagacgcaa gttggtcaag accagagccg aaattccgtg tgccattagg
     5881 tattggccac tcgttcctga caacccccaa gcaataccag ccacaactgt tagtaaagtc
     5941 ccttttaaac tatttgacat gtctctcctt actcttcttt acgaatcaag ttcatcactt
     6001 gattgcggtc taatatccat tgagctctct cgtccttttc ataggtacga ttcgatagga
     6061 aaatagtggc ttcttgcttc tgacgattcc acatgataaa ggtacctgta tagcccgtat
     6121 ggtctagcca atctccttcc aaattccatg ctaaagaacg ttccttgtca tccaaaggag
     6181 aaaaattttg atttaagtct cttgcaaaat catctgctaa atagtgttct aaaaagattt
     6241 gtaaatcctt tatagtcgaa aataaaccag cactcccagc atgtctaccc aggagacgag
     6301 ccttgggatc atgcactatg cctgcctcta cacctctaac tgttggaaca gcaagctcaa
     6361 ctggcccaaa cttggtttcc gtcattcccc aaggtttcca gacttgatcc tttaaaatca
     6421 catccaaatc ttgattaaaa attctttcca aaataaagcc caacagcaaa aaatggacat
     6481 ccgaataaag aaaggctggc tgacttcgtc tgttgagatg aaacatcgct tcctttaatt
     6541 caggggctgt taaaagatca cgattaggaa taaaaggatc aaggtctgtt gcatgagtca
     6601 agagctggcg aatagtgatg tctggataat cactctcagg taaaaaatct attaccagtc
     6661 tatcaatatc taattgacct atttcccaca agaaggtaca aactgtgcca accccaacaa
     6721 ccttgctgac actagctagg tcataaacta gtcctgcctc agtctgcaag ccatgctctg
     6781 ggtcactctg gcctaaatag aactctgtcc attgattgtc cttaaaatac gcaaaagagg
     6841 ctccgggata aattcctgcc tcgatttgtt cttctatttt tttaataatc ttggtccact
     6901 tcatacttct tcaaaccaca attcaacatt atttctatct ttacaaagga agaatttttc
     6961 agacttagga ataaaatatt cagtagactc aaacttctgg cgaagacttg ctatgtctaa
     7021 ttcattgacc aagaacttga gcatagataa gtcccaggta accgtattgt ccacagtcaa
     7081 atcctgcccc tgagctggaa taaaatcaag ggatgcccca atttcagatg attccaagaa
     7141 actttcgata tcagttggga gatgtaattc catagaaatc tcaaatttac ttaaagaaat
     7201 tgatgccaaa tctgtttgaa attcaggctt ttctcctact tctactagac ttgctctgtc
     7261 atcttccgca tgaatcaaaa tcaaatcatc ttctggtgag aaaatttcaa aagcgtagcc
     7321 attttgacct ttatataatc gatgaatcga atctgtttta gataagattc cttcaatttc
     7381 taagggattt tccaccttga caatcaatct agctagtttt tttcttccct ctaccttacg
     7441 agtacgcata ctgggagctt cttctaaaac cagcttttca agacccgttt ggtcacctag
     7501 tgacagaaag gccgattctt ctaacaaggc cttcattcca agggtttcaa tataaaatgt
     7561 ttcatttaat tttctattat tagcttttaa agtaggaata atccgtacaa tctgatttac
     7621 attcataaat tcctccgtca ctttttattt taaaggattt tagaattttt tacaagatat
     7681 tatgctcaaa tttaacatta tttagctatt tagtaaagat agtctttcaa ggcttttgac
     7741 aaagcctgat aaccagcaat actgaggtgc agtccatcag ttgtatattc ttttttgagt
     7801 tggcctgctt ggtctgtcaa acaatcaaat actggcacaa attccacctg catataggca
     7861 gatgcaagct cttgataggc ttgattccag ttctgaattt tttcattcga gcggatatag
     7921 actgcctgct ggtacttctc tccctcattg acaggcaaaa tggaaagcaa tttaatctct
     7981 gtcaatggat aatcgcgagc aacggattga atgatagctt cgagattatt gagagcctca
     8041 ttcacaggaa catcctttcc gatatcattt gtcccaatca gaagaaaaat tttatctact
     8101 gctccaccat atagatgagc atcaaggttc tctagtaaca gtcctgtctg atagccacga
     8161 attcctcgat tgacaatcgt ctttgaagtc ccaaatagct cctgtagagg ataatactcg
     8221 acaatggaat ccccaataaa aagaatgttt ggttctacaa cagaaatgtg atttaggtga
     8281 cgatatttgg tttgaatttt ttcttgttcc tttaggagcc aattttctaa taactgtact
     8341 gccacttcat tctccttttt ctaaccagtt ttccaagact tgataaactc ctccttggct
     8401 gttggctggt gctagagcag tcgccacagc tttggctttc tcatcagcat tttccatcgc
     8461 ataggcaatt ccagccattt caagcatttc aacatcattt tcactatcac caaaagccat
     8521 gatttcttgg gatttcaagt cccagcgctt gagtaattcc tccaagcccc atgctttatg
     8581 aatcccagct tggaggatat caatgcaacc atagccactg gatacagctc ggacacggcc
     8641 atcaaagaga gcattgattt cttccaaaac cgaactcaaa cgttcctcac caacaaccat
     8701 gctcatcttg agcacaccac caaagaggtc agatgttaat tcatccacaa attgcatccg
     8761 ttggtagaat ttttcaatca tttctggagt cataaaactt tcaagatctg taaaaatcgt
     8821 accttccttg acaaaatcac ccttcagccc cgttacaaca aactggtcct gacacgctcg
     8881 acccttgaaa tgagccaaag ccttgttgac aatggcgtca tcccatgtct gagcctgaat
     8941 caattcattg ttttcaaaaa tacgagcgcc attagcaaca accagaacca ctcgatccac
     9001 caagggactc agtagttgtc tcatgcggtg aatttcattg cccgtcgcaa tgacaaaacg
     9061 aatgcccctt tgatccaact gatctaaaat cttttccaat cgtgggagat caagctgacc
     9121 cctagcatcc agcaaggtcc catccatatc tgtcgcaatt accttaatca tcatttactt
     9181 tcctctggat tcaagctaat accacttcaa tcccacatgt tcattcattt ctttataggc
     9241 tgtatcaatt cgttccttag tcgcttcatc taactggtca cgatgactgc cacccctcta
     9301 taaaatcttc caaaatataa gtttggtaat gatacaaggg atatccttct ggtgaaaagg
     9361 ttccctttgg tgttcgattg acccaagtag gatgagcttt agctgttccg atagttgttt
     9421 ttccatcctt cttcttgatg gtgacatcca tgagaacacc acgttcagtc cacttagcat
     9481 tctcttcatc tcccatagat tcaattcgtt gattggaaat gaagttcccc atttaataga
     9541 taatgagttt cttatctcca tctttttcaa ccgtttcaga tggttcaaca acgtgaggat
     9601 gccctccaaa gataatatcc gctcccaaat cgatcatctt gtgataaaga gctttttgtt
     9661 cttcagttgg ttccaatcga tactcaacac ccatctgaag catgataatg gtgatatctg
     9721 cttccttctc tgcccgttca atttcaacct tcatcttatc ttcgtttaaa tctgaaagat
     9781 aacgattata gtcttcctga gaaatatact gctcaattcc attgaaacca taggaatagg
     9841 ctaacaatgc aaccttgata ccattcactt ccttaatgac cagcggagcc tgatcacgtg
     9901 gttcgtgcgt ataaactccg attggagtga ttccagcttt ctcaataata tcggccgttg
     9961 aaataactcc ctcaatttgc gaatccaaaa tatgattatg agctaaatcc agcacatgat
    10021 aacctgcctc cttaatagca tccataactt caacaggagc attaaagaga agataacccg
    10081 ctaaataatg atccttatta atggttcctt caaaatcacc aatagctaaa tctgctgctt
    10141 agtccccttg cttgagccaa ggagtcacat actcaaaatt ttcatgaaag tcataggtac
    10201 cgtcttcttt tttagctgaa aagaaaagtc catcgtggta gagcaaatcc ccgtgggcca
    10261 taattctggc agttttttcc tcttcctact cctgagactt ttgcttagtc ccctcttgag
    10321 aaatagtatc tcgtttttga ctagtcaagg gattccttgg aagctttcaa acaacaagac
    10381 caagcccatt gataaaccaa ctgctagcaa gagtatcgcc acaaatccct tattgctcca
    10441 cttgcgataa ctcctaaaaa gtttaccaag cccttcataa aacgaaaagc taaaccaccc
    10501 tgatttcgat tttgtcttct ttgtatcttc gttctcccta ctttcttatg caagcctttt
    10561 ctttttatta tatcacagat aagtatttct ttctcaattg aattgaactt cccatctatt
    10621 ttctataaat cctaaatgcc ataatgcttt caattcttgt cattttgtga tatcatgtag
    10681 aggaaatgaa ctaatccaca gtggcttatt ccaagtatac cacttgggct ttggcagtag
    10741 ctaactgcac taaacataat ataaggagag aaaatgtctg caatagaacg tattacaaaa
    10801 gctgctcact taattgatat gaacgatatt atccgtgaag ggaatcctac tctacgcacg
    10861 gttgctgagg aagtcacttt ccccctatct gaccaggaaa tcatcctagg cgaaaagatg
    10921 atgcaattcc ttaaacattc ccaagatcct gtcatggctg aaaaaatggg actccgcggt
    10981 ggtgttggac tggctgctcc ccagttagat atctcaaaac gcattatcgc tgttttggta
    11041 cctaatattg ttgaagaagg cgaaactcca caggaagcct acgatttgga agccattatg
    11101 tacaatccaa aaatcgtctc tcactctgtt caagatgctg ctcttggcga aggagaaggt
    11161 tgcctgtctg ttgaccgtaa cgtgcctggc tatgttgttc gccatgcccg cgttactgtt
    11221 gactactttg acaaagatgg agaaaaacac cgtatcaaac tcaaaggcta caactccatt
    11281 gttgttcagc atgaaattga ccacattaac ggtatcatgt tttacgatcg catcaatgaa
    11341 aaagacccat ttgcagttaa agatggttta ctgattcttg aataaagaaa atcccgttgc
    11401 aagacggggt tttgtgttat aatagaggca tgaaaacaaa tgatattgtc tatggtgtcc
    11461 acgccgttac cgaagccctc cttgcaaata caggaaacaa actctacctc caagaagatc
    11521 tccgaggtaa gaatgttgag aaagtcaagg aactagctac agaaaagaag gtgtccattt
    11581 cttggacatc aaaaaaatct ctctctgaga tgactgaagg tgctgttcat caaggttttg
    11641 ttctacgagt gtctgaattt gcctatagcg agctagatta catccttgca aaaacacgcc
    11701 aagaagaaaa tccacttcta ttgattctag atggtctaac cgatccccat aatctgggtt
    11761 ctatcttgcg aacagccgat gcgaccaatg tttcaggtgt catcattccc aagcaccgta
    11821 ctgtcggagt aactcctgtc gttgccaaaa cagccacagg tgctattgaa cacgttccaa
    11881 ttgcccgagt gaccaacctc agtcaaacct tagataaact taaggatgaa ggtttctgga
    11941 cctttggaac ggatatgaac ggtactcctt gccacaagtg gaatacaaaa gggaaaatcg
    12001 ccctcatcat tggaaatgaa ggaaaaggta tctctagcaa catcaaaaaa caagtcgatg
    12061 agatgattac cattccgatg aatggacatg ttcaaagcct taatgccagt gttgctgcgg
    12121 ccattctcat gtacgaagtt ttccgaaata gactataaaa aagtttccag tcatctgatt
    12181 ggaaactttt ttatgattaa ctatgttctg taatgaattt ataggcttct tgaccagcga
    12241 tagctccatc tccaaccgct gttgttactt ggcgaaggtc tttcaagcga acatctccaa
    12301 ctgcaaagat accgtcgact gcagttttca tgtggttatc tgtcacaatc catcctgcct
    12361 gatcttggat attcaattct ttaacaaaat cgctaagagg gtccaaacca acatagataa
    12421 agacaccacc gaaggcttgt tctgtcactt gacctgtttt cacattttca aatacgactg
    12481 attctactcg gttttcaccc ttgatttccc ttactacaga atcccagata aagctgattt
    12541 tttcattcgc aaaggcgcga tcttgtaaaa ccttttgggc acgaagttgg tcacgacggt
    12601 gaacaatggt aacagtctta gcaaaacgag tcaagaagag ggcttcttca acagctgaat
    12661 ctccaccacc aactaccaat aaatcttggt cacggaagaa agcaccatca cacacagcac
    12721 agtaagaaac accacgactg ttcagttctt cttctccagg cactcccaaa ggacggtgtt
    12781 tagaaccagt tgctacgata actgtacgtg tttcatatgt ttggtcatca gtcatcactt
    12841 tcttaaaatc accatggtct tcgacatttt caacataacc ataaatgtgc tcaacaccaa
    12901 gattttcaag tggttcaaac atcttttcag ccaattcagg tccactaata ttagcgtatc
    12961 ctgggtaatt ttcgatatca gatgtattat tcatctgacc acctggcaga ccaccttcaa
    13021 tcaaagctac ttttagattg cttcgagcag catacaaggc cgcagtcatc cctgcaggtc
    13081 cagcaccgat aataatagta tcgtacatat agattccttc tttcttgttg taactatctt
    13141 tattctaact ctttcttgtc aatcacgcaa ggattatgcc ttgaaaacaa gaattaaact
    13201 cataaccgca aaggataata ctgggacaac caagactcca atcataatca tatcatagag
    13261 atgggcttgg cgagccctgg ctgtcttatc aactcccgac atggctctca gaccaatcca
    13321 aatccctaaa aaaatcagaa caaggatggt ggtcaagatc aaactctcga aatataaaga
    13381 aaatagttgc agtagcatga tttctctcat ttctatcttt tttaaagagt aaactcagct
    13441 agtccaacta actgagtttt cctttatcta ttatatcaaa tataagtccg tttgtaacta
    13501 gcgaagaatt cttttgtccg ctcttcttta ggggtgtgga taatctcatc cggagttcca
    13561 gactcgatga ttttcccctt atctaagaag agaatcttat ccgcaacttg ggctacaaag
    13621 gacatgtcat gactgaccaa aatcatggtc tgacctgact tagcagcatc tgcaatagac
    13681 ttttctactt caccgaccaa ttctgggtca agggctgaag ttggttcgtc taagagcaaa
    13741 acatctggtt tcatagcaag cgcacgcgct agggcaaccc gttgcttctg tccacctgat
    13801 aaatggcgag gataatggtt ttcacggtcc gaaagcccaa ccttagccaa ctcttccttg
    13861 gcaatcttag tcgcttcttg gtcagataat ttcttgacaa caaccaagcc ttctttcaca
    13921 ttatcaagtg ctgttcggcg ttcaaataaa ttaaactgtt ggaaaaccat agacaactta
    13981 cggcgtaggg caaggatttc ttcttgagtg attttagaaa aatcaactga aaaaccatca
    14041 atctgaatag agccactgtc aggtgtttca agataattga gactgcgaag aaaggttgat
    14101 tttccagctc ctgaagaacc aatcaaggct acaacttccc ctttttgaat atccaagtcc
    14161 agatgatcca agacagtctg tcctgaaaag gatttgctta aattcgaaat cttaatcatt
    14221 aacgaaggtc tcctttcaca tctgtttgca ctgtatcagg tgcagaaata gccatttttc
    14281 tctcgatgaa acgaccgagg ctttcaattc cgatattgac tacccaataa acaagggcaa
    14341 cggagatgaa gcgttcaaaa tagcgataat cagctccacc tagaatctga gcttgggcaa
    14401 agacttccac aacacccgca ctaaaagcta gagatgttcc cttggtcaaa ccgatgaggg
    14461 aattaatcaa ggttggagta gctaccaccg ctgcattagg aataatcact cgtcgataaa
    14521 cttgcgctcg ggtcataccc agactgcgtg ccgcctcaat ctcaccagga ttaactgaga
    14581 gaatggctgc acgaatggtt tcactagcat aagctgcctc attaaaggca aaggcgacaa
    14641 tcgcaaaagc tgcagctgga atcgcattga tattgagacc agttccccat tgctgattga
    14701 gggctttcaa agccaaaggg attccgtagt aggtcaacat gagttgcacc aaaatcggtg
    14761 tcccttttaa gaaactaaca aagaaggcct gcaagggata taaaatcttg acacgattga
    14821 tcttcacaat ggcaaaaaga agcgccaaaa ccaagccaaa aagggcacca ccaattgtca
    14881 acataattgt tgttggaagt tgttggacaa ttctagggat tccatcaaag accgaacgta
    14941 ggctaaacag cttgccatcc ggaatcaatt gcatcaagtt ttggtaccaa tctgatgcta
    15001 aaatcgttgt aacattcata aaaacatcct cttctgataa tgattcattc taccatgctt
    15061 ctgccgtcaa tgaaattatt tgctacggtc agatacagac tttgtctacc tactagttta
    15121 tcatactttg aaacagggaa gttatatatt ttatctatca aagagataga taaaaactat
    15181 ttcagtccca gttcttcata agattttcga taaccgattt gcttaacggt tccattttct
    15241 actaaaatgg gccgttttaa caacataccg tcacttgcta gcaactcagc cgcttcttgg
    15301 tttgacaaac ttcctacctt atcttttagc cctaattcac ggtatttgat accactggtg
    15361 ttgaaaaatt gcttcaattc aaatcctgag gtttctagcc aattcaaaat gacttcttgg
    15421 ctaggtgttt cttccacgat atggacggct ttatagtcca cacctaattg atttaattct
    15481 tgttttgctt ttttacaagt tgaacatttg ggatattcga taaattctaa catgtgcttc
    15541 tccttctatt gtttctatct ttaaaatcta ctccttcatg ctccaagagc caagctttct
    15601 tttccactcc tgcagcataa cctgtcagac gcttgcctgc tcccaacaca cgatgacaag
    15661 gtactaggat agaccaagga ttgcgtccca ctgctccacc aattgcttga gcagaagcca
    15721 cttgcaggtc ttgagcaatt tgtccatagg tcactgtctg accataagga atgccctgta
    15781 aatagtccca aactctcttt tcaaaattcg ttccgattgg cgccaagagc aagttggata
    15841 aatcctgagg cttgccttta aagtaatcat ctaagcaagc aataactggg tctaaaatag
    15901 gatgactaac aacttcttct atcgtttcat ctcctagtcc cctctcaaaa tgcttctgct
    15961 cctgaaccca aattccatac aaataatggt catcagctac aagtgataga ataccaattg
    16021 gtgaggagta gagtattttt acatacttct tttgcattat ttctttaatt tttgataggc
    16081 caagcgttcg ccatctactg gcaccttacc aacttgttta aaaccaagtt tttcaaaaat
    16141 atgttgcata accttgtttt cagcatgcgt atctgagcga aaatcaagat aatcaaaacc
    16201 ttcaatcaag ccctctaaga aggtttgagc aactcctttt ccctgcacat ctgctgccac
    16261 agcaatacgg tgaaagacta gatactctga ctctccagct tgccagtttc cctcataaat
    16321 agcttcatag gcctcctctg gactcttggt cacagcagca taggctagca gttctccctc
    16381 ttccaaggct acgtaggctt gccctgagat aatatcatcg ataataacat ctgcatttgg
    16441 atagccattt tgccactggt cactaccagc atctgctaaa cattttttgg catcctccat
    16501 cacctgcatg atggcatcta cttcatttgg aaaagctaaa cgaatttcca tcttttttcc
    16561 tcatttctga ctagtttctc ccatcatagc ataatttaag tatttctaca agcagttaaa
    16621 acttgacttt gtgtttttgt tattttataa tctagttatc aaaactatat aaaaaggagt
    16681 tgaaaatgaa aactaccttt tcctacccaa aatgggcaga aattccaaac attgacctct
    16741 atctggacca ggttttgctc tatgtcaatc aggtctgcgc ccctatctct cctaataaag
    16801 acaagggcct aacagcatct atggtcaaca attatgtgaa aaatggttac ctgacaaagc
    16861 ctgacaaaaa aaaataccaa cgccaacaga ttgcccgttt gattgctatc acaaccctca
    16921 agtctgtatt ttctattcaa gaaatagccc agacacttaa tactctacaa actcaagcaa
    16981 gttcagacca actctacgat gcttttgtgg actacatgaa ccaaggaatt gacccagcta
    17041 accctattat ccaaaccagc tgccaaaccg ttaaactcta tcatcaaact ctagacttaa
    17101 tcgatcatac tcaagaggag gtaatccaat gaacactagt cttaaactca gcaaacaact
    17161 cagttttgga gaggagattg ctaatagcgt gacccatgct gtgggtgcag tcatcatgct
    17221 tatcttgctg cctatttcat ccatctatag ttatgaagca cacggatttt tatcctctat
    17281 cggcgtttcc attttcgtca tcagtctctt tctcatgttc ctatcatcca ccatttatca
    17341 ctctatggcc tatggttcga cccacaaata tgttttgcga atcattgacc attctatgat
    17401 ttacgttgcc attgccggct catacacgcc cgttgtcttg accttgatga ataactggtt
    17461 tggctatctg attattgtca tccaatgggg aacgaccatc tttggtattc tctataaaat
    17521 ctttgctaaa aaggtcaatg agaaatttag ccttgctctt tacctgatta tgggctggtt
    17581 ggttctggtt atcattcctg ccattatcaa tcaaacgaca cccgttttct ggagtctcat
    17641 ggtaactggc ggactctgtt atacagttgg agctggattt tatgccaaga aaaaacctta
    17701 tttccacatg atttggcatc tctttatcct agctgcgtcc gtactccaat acatcgctat
    17761 tgtttattac atgtaaaaaa gttgagaaat tcaatctcaa cttttttctt tacacatatt
    17821 gataaagtac tggtgcaagc gcacatcatc agtcaattct ggatgaaaag aacttaccaa
    17881 catatttttt tcttgggctg caacaatttg attgttcact gttgctagaa tttctacacc
    17941 ctcaccaaca ctactgataa tcggaccacg gataaaggtc attggaatct tgccaactcc
    18001 cttacattct gcttccgtgt agaaacttcc taattggcgc ccataagcat tacgctcgac
    18061 caccatatcc atagttccta gatgactctc tttctgagaa gtgatttcct tagccaacaa
    18121 aattaagccc gcacaggtcc caaacactgg taagccagat agaatggctt ctcggatggg
    18181 aagtagcatg ttctggtcac gtaagagctt gcccatggtt gtagactcac caccaggcaa
    18241 aatcaaaccc gacaagtcac tctgatcttg ctgaaaatca tctagatttc tgagttctac
    18301 actctcgaca cctaattgat ctagcacttt tgcatgttct gcaaaggccc cttgcaaggc
    18361 caatattccg attttcatct attttcctcg ttcagccatg agaatttgga tttcattttc
    18421 attaatacca accatggctt ctcctaaatc ttcagagatt tgagctagga tttgaggatt
    18481 acggaagtta gtcacagcct taacaatggc actcgctcgt ttaacaggat ctcctgactt
    18541 gaaaatacct gaaccgacaa agaccccctc tgcccctaat tgcatcatta acgcagcatc
    18601 tgctggcgtt gcaacacctc cagcagcgaa atttacaact ggcaattttc catgttcatg
    18661 aacatattgg accaattcta cagggacttg caaatccttg gcagcaacat aaagctcgtc
    18721 ctcacgtaag ttttgaatgc ggcgaatttc ctgattcatc atacgcatat gacgaacagc
    18781 ttggacgata tcccctgtcc ctggttctcc tttggtacga atcatggaag caccttcagc
    18841 gatacgacgc aaggcttcac ccaaatcctt agcaccacag acaaaaggaa cttggaattc
    18901 tttcttatcc acatggaaac ggtcatcagc tggagataga acttcactct cgtcgatata
    18961 atcaatttca atagcctcta aaatctgagc ttcaacaaaa tgcccgattc tgaccttagc
    19021 cattactgga atactaaccg cttcttggat ttccttaatc atctttgggt cgctcatgcg
    19081 ggaaactcct ccagctgcac gaatatcagc cggaattcgt tccaaggcca tcacagctgc
    19141 cgcaccagca gcttctgcga tacgagcctg ttcaggattc tgtacatcca taataacacc
    19201 acccttgagc atctgtgcca agtttttatt tagttcataa cgattttcag tcatttgttt
    19261 tatcctcatc atttgtattg gtagctacct tttcatttta agtcagaaca gaatgaagca
    19321 caagataaaa aaactataat tgtatgggga cagattggct aaaaactatc tgaccttaac
    19381 ttaaggccag atagctcatt catttttatt tttcagccgt aagggcagcc attgtgatgt
    19441 agttgtatgg tttgttgaag tgtggcaaga agaagaggtc tgtcaatgcc aatttatcaa
    19501 ttgtcacatg ctcttggata gcaagtgaga acatgtggat tcccatgcta attgcaatat
    19561 catgtgaaac catttgggca ccaagaattt cacggctatc tttgtcaaag acaatcttaa
    19621 ttgctacttc atggttgtca tgtttcatga attctggttt ttgaagatcg ttaaagcctg
    19681 tttcagttgc gttgtaacca gcagctttcg ctttttcaag agtcaaacca gttgaaacca
    19741 tgtgaagacc gtagattgag ataccatttg aaccttgaac accgattcct tccaattcat
    19801 gtccacaagc attgtaggca ccaacgatac cagtgcgaac agcatttgaa gcaagagcga
    19861 tatagcttgt atctttacga gcattgtcat aaacagtcgc acagtcacca acagcgtaaa
    19921 cgcctgggat agatgtttct tgtttcttgt ctacaaggaa ggcaccgttg cggaagagtt
    19981 cgatcttacc atctgcaagg gctgtgtttg gacgaaaacc aactgcaagg ataaccatat
    20041 ccacgtcaaa gctttctttg tcagtaatca agcgttcaac tttaccgtca ccttcgattg
    20101 ctttaacagt ttgacctaga gccaagcgga tgttgtgatc ttccaagttc ttcgccatca
    20161 tttgtgtgaa gtctttgtca tagtaaccgt tcaagacagt atcaacgata tcaacaagga
    20221 caacttcttt tccaagacgt tcaaaggctt cagcaagttc aacaccgatg taaccaccac
    20281 caacaacggc gatacggtcg aggtgttggc tcttgtcaga aagtttattg ataacttctt
    20341 cagcattttg gtacaatttc acgaattgta cgttttcaag agttgcttta aactcgcggt
    20401 ttcctttaac aatttcaaca ccttcgattg gtggcaagat tggtgtagaa cctgtagcga
    20461 aaatcaattt ttcgtatgat tctttgtgct cttttccttc aacttccgct gtaactactt
    20521 tgttatcata gtcgattgaa agaacaggtg agttcatgta aactttagca cctttagctt
    20581 ccaatttttc tttatcagaa tagaacaagc cttcagcacc gtcaatttgt tcaccaatcc
    20641 aaagagccat tccacatcct aggaaagaga tgttagagtt ttggtcaaat acaacaattt
    20701 cgttctcatt tccaaaatta tccaacatgg tattaataca tgctgtacca gcgtggttag
    20761 caccgactac aacgatttta ctcataaaaa tttcctgcct tcattctaaa tttaccttac
    20821 tagtatacca tttaccgtta gcgtttacaa ggggggtact attatttcag cattttttat
    20881 caaaaataat tccccattta tcctgttttc aagcctcatg aattttatga gcatatttct
    20941 tgactttttc caaattttgt ttgtgaaaat tctaacttta tggtattata ataacatgaa
    21001 aatgaaatgt aagggcttca atttagatga ttatttgata ttacaactta ttttctataa
    21061 gagaaaggag ttggtagctt gactcttcgt tcacattctg aacggctaat ggggactact
    21121 atcactattt cattagtgga tgagcaagcc gatatctttc tccaaaaatc ctttgacttg
    21181 ctcaaagaac ttgaataccg cttcaacgcc aatagtcaag aatctgagtt gatggaaatc
    21241 aattatcaag caggaatatc ccccgtcacg gttcatccag acctgtttga gctgatttca
    21301 cttgggttag agcatagcct agcgctctct agccacctca atatcagcat tggtccctta
    21361 attcaaacct ggcgtatcgg tttttcagat gccaaggtcg cccagcctca agaaattgaa
    21421 tcggtgctgc ctctaatcaa tcctcatggt atcgagttag attcttctac ttctactgtg
    21481 tttttaaaac agaaaggaat gaagattgat ctaggttgtt tagccaaagg atacagtgcg
    21541 gataaggttg cccaatttct taggaaagag ggggtgactt ctgccttgat caatctggga
    21601 gggaatatcc tgaccattgg aaaaaatcag gcaagagggg ataacccatg gcaaatcggg
    21661 attcaagacc cagccaatcc taggggaaat catttaatga ccatccctgt tgtcaataaa
    21721 tctgtcgtga cttcaggcat ttatgaacgt cacctgaccg tcgatggaca agattaccat
    21781 cacatttttg acagtcaaac aggatatcct gttgaaacgg aactagcgag tctaacaatc
    21841 atctctgata aatcagtcga tggcgaaatc tggacgactc gactctttgg agaaagacct
    21901 gcttctatcc tctggcaagt cgaaagtttg gagggtatcg aagtcatcct catcgataaa
    21961 gaaggccacc taagctgttc ttcaggaatt cctactctat agagacaact gtttcaatgg
    22021 aattttaaaa ttgtattatg taaaaagaga aaggaaatct catgttaaaa cttattgcta
    22081 ttgttggaac aaattcaaaa cgttctacaa accgtcaatt gcttcaatac atgcaaaaac
    22141 actttgctga caaagctaaa attgaacttg ttgaaatcaa ggccattcct gtcttcaaca
    22201 aaccagctga caagcaagta cctgctgaaa tattggaaat tgctgctaaa atcgaagagg
    22261 cagatggcgt tattatcggt actcctgagt atgatcactc tattccagct gttttgatga
    22321 gcgctcttgc ttggttgtct tatggtattt acccactttt gaacaaacca atcatgatta
    22381 caggtgcttc ttacggtacg cttggttcat ctcgtgccca attgcaactt cgtcaaatct
    22441 tgaatgctcc tgaaatcaag gcaaatgttc ttccagatga attcttgctc tcacactctc
    22501 ttcaagcatt taacccaagt ggcgacttgg ttgaccttga tgttatcaag aaattggatg
    22561 ccatctttga tgacttccgt atctttgtaa aaatcacaga aaaattacgt aatgcacaag
    22621 aattacttcg caaagatgct gaagactttg actgggaaaa tttgtaagat aggagaccaa
    22681 aaagaatgaa atttgttgga cttgttggat caaactacga tcaatcatat aaccgtaagc
    22741 tcttggaatt tatccgtcgc tacttcaaac tcaaatttga attagaagtt cttgaaattg
    22801 acgaagttcc aatgtttaac caagatgaaa aatgggatga aagtttccaa ttacgttatt
    22861 tatataacaa aattactcgt gcagatggtg ttatcattgc tactcctgag cataaccaca
    22921 ctatctcagc ttcactcaaa tctgtacttg aatggctttc atacgaagtt catccatttg
    22981 aaaacaagcc tgttatgatt gtgggtgcat catactatga ccaaggaaca tcacgtgctc
    23041 aagttcacct tcgtaaaatc cttgatgctc caggtgttaa tgcctacacg cttccaggta
    23101 acgaattcct tcttggtaaa gctaaggaag cttttgataa caacggaaat atcaccaacg
    23161 aaggcactgt taaattcctt gaaacttgct tagataactt tgttaaatac gtaggagtcg
    23221 tttcgaaatt gaaaaaacca aaaccaatcg aatcagaaga cttggattgt ggaaaaccaa
    23281 tcgctacaac catcacagaa gttgaccctg acgatccaga atgggtagaa aaagttgcag
    23341 caatcactgg tgctgtttct ggtgatacct atgtcaaatt ggaccacggt atcctaacag
    23401 ttaaccaaat tgatatgttc ttgaaagcta tgccatttga attgacatac gctgacgaca
    23461 acaaccaatt cctctactac aacaacgctc accaagatcc agacactatg ttcgctaaac
    23521 gtgtaccacc tcaatcaggt agccgtatgt cgactgttca tggttctctt ccaccagcac
    23581 gtatgaagaa cgtagagtgg gttatcggaa cacttcgcaa cggaaaccaa gaatacgtcc
    23641 gtacgatcgt tccaggttct cctgcaggtg ttatcaacac tcacaactac caagcaatgt
    23701 actatcctga tggatcatac gctggtatca atgaaatcgt ctttaacttc caaccatggc
    23761 ttgactggta cctaaaagag actggtcaac gtttgatggg tggtagcgga ccatttgctc
    23821 ctgctgccgg aggtcatgga gacgccgatg ctacttctgg cgcttctgat tcaggggatg
    23881 ctggaggcca cggtggtgac gcagacgcta cagccggtgc aagttactaa tgatagtttt
    23941 taggaaccat tatggttcct tttttagcga aaaaagacta gcaaacacaa actgctagtc
    24001 tctttgttat cgtttcatct atctttgtta aaagaaagag tacatattat gaatttgggt
    24061 catcaagact acggccatgt aatccttttt cacgttgtac ttggcgtagt ttttctggtg
    24121 taacatcgtt tccttcttcg tccacaattt tgattccttc aatgtggtga cgaacagcgc
    24181 ggcgataacc ttcgatgtac tcctcacgta gtttggcttg ttccactttt tcttctggtg
    24241 ttaagccttc tgtttttttc tttttagcaa gctcattgat acgagcaatt tttttcggat
    24301 ccatttcttc tcctttgtaa taagataaag tccgtttatc aaattttatt tagtgttaat
    24361 ttggttaaaa caagcaaact tagctgcttt cttggttagt tgtgacaaga ttgccaaacg
    24421 attttgacgg acagcctgat cttcagccat taccatagta ttttcaaaga aagcatcaat
    24481 gactgggcta agcgcaaaga gttgtttcaa ttgctgactt gcaggtcctg ataaaacgag
    24541 tgtttctact gcttctgcca aagctttttc ttggtcattc tcaaatagtg ctgaatcaac
    24601 tgtagcaacc ccttctgcct tctcagccag gttaaaggca cgagaaagtg attcaacaga
    24661 tggtttaaaa tcttcttcct tgcttacttc tacgagagca cttgctgctt ccaacatatc
    24721 tgccacaaca aagtttgaac ctgcaagaac tgcttccttg atatcttttg gagtagagcc
    24781 catcatctta tcaacacgag ccttgataaa gtccataacc tctgctttat tttcataagt
    24841 caaactgtca aatttcaatg cataaaggct atcaatcagc tcatccatag caatgtgcca
    24901 accaaaggca tccaagatac gaaccacacc ttgagttgca cgacgaaggg cataagggtc
    24961 attagaacct gatggaatca atcctactga gaagaaactc aaaatcgtat ccaatttgtc
    25021 tgcaatggct agaactgcgc cgaccttgct ctctggaagt tctccttcag ctgatgtagg
    25081 catgtagtgt tcacgaatag cagctgccac cgctggagtt tcaccagcaa gaagggtgta
    25141 tttttcaccc ataattcctt ggagttcgtc aaattcacca accatacctg tcaataagtc
    25201 aaacttgtaa atggctgctg cacgagcaag gtcaactgtt tcatccactg acaaatcagc
    25261 tttttctgcc aaaagtacag tgatttgacc tgtacgaatc atgtgttcac gaagggaacc
    25321 aatcttctca tggaaggtga cattgtttaa tttttcaaca agatctgaaa tcaccaattt
    25381 ttggtcttca cgccagaaga attctccgtc ttccaagcgg gctaccaaga ctttttcatt
    25441 tcctttaatg acatttttca aacgctctgc gtttccgtta cgaacagaaa tgaagtttgg
    25501 caagagtttt ccatcttgat cacgaacaac aaagtaacgc tggtgttcct tcatagaagt
    25561 caccaagact tcttctggaa cttcaaggta tttagcatca aaacttccca tgaaggcagt
    25621 tgggtattca accaaattca agacttcatt cagcaaatcc gcatcaattt cgatacgtac
    25681 atcatgtttt gcctcaattt ccttgatttg gtcaacaatc atttgctcac gttcacatgg
    25741 atctgcgatt acaaactgct tacgaaggtc ttcttcatag ctcaatgctg actgaatttt
    25801 ggtttctttc cccaagaaac gatggccacg gctcacacga cttcccttga tatcaaggaa
    25861 atccaagtca aactcttgct catccaagag aacagttaaa gtgtgaacag ggcggatgta
    25921 ttcaaagcta tttcccgccc agtgcatgct gacagggaaa gtcaatgact tcaatacatc
    25981 cacaatgcct ggaacaatgg cttcaactgc ttgaccaatt tcttccttag tgacatagac
    26041 atattcttca cccttgattt cacggaattc gatatcttca acagtcaagc cttttccacg
    26101 gacaaatcct tgagctgctt tggtgaagtt tccatcacta tccaaggcaa ttttctttgc
    26161 tggtcccttg aaatcttctg tcaaatcaga ctgtttgtct gataaaccag tcacacgaac
    26221 agccaaacga cgtggtgttg agaaggtttg aatggcttca aaagacaggc gttttccctt
    26281 gaggaaggct gccatttttt cgcctagttg tttttcactt ggtgtgacaa cataggctgg
    26341 taattcttca agaccgagtt ctactaataa gttttttgtc atgttttttc ctttacattt
    26401 tcttcaatct tttttgatat gcaccttagg tactggggac gtcgctaact aactctgtga
    26461 gtctgtatgg aaatccaatg ctaaatttat caagatttcc aacaatctca tcaaagtgga
    26521 tttagctgac tgatttttga acctaaggtt tcaaaaatcc ccacctaaca gtacggcggt
    26581 gcatatccct ctagcaagtc ttcgacttgc ctctaacgat tttagagtac agtattactc
    26641 actattctgc gtcttctgct aaaagtttaa ctcgtgtttc ttcatccaaa agtgggtaac
    26701 ctaggcgttt gcgttctgca acaaaggttt tggctacaac acgggccaag ttacggatac
    26761 gagcgatata gcctgcacgc tctgttacag atacggcacc acgcgcgtca agcagattaa
    26821 aggtatgtga acatttgaga acatagtcat aggcagggtg taccaagcct tcttctaatg
    26881 cacgaccagc ttctttttca aacttatcaa agttttcaag caacatttct tggtccgaaa
    26941 tttcaaatga atattttgag tgctcatact caggctggat aaagatttct ccgtatttta
    27001 caccatcagc ccactcgata tcatagacag agtctacttc ttgaatgtaa gaagccaagc
    27061 gctccaaacc ataggtaact tccgcagtca cagggccagt tgccaatcca ccgacttgtt
    27121 ggaaataagt gaactgagtg atttccattc cgtcaagcca aacttcccaa ccaagaccag
    27181 ctgaaccagt tgatgggttt tcccagttgt cctcaacaaa acgaatatcg tgctccaaag
    27241 gattgattcc caatttttcc aaagactcaa ggtaaagttc ttggatattt gatggagaag
    27301 gcttcatgac cacctggaat tggtggtgtt ggtagagacg gttagggttt tccccataac
    27361 gaccgtcagc aggacgacgt gatggctcta cataagctgc attccatggc tcaggtccga
    27421 tagcacgaag gaaagtgtaa ggactcattg ttcccgcacc tttttcatta tcataagcct
    27481 gcataagcat acaaccttgg tcattccaaa attgttgcaa agtaaggatg atttcctgga
    27541 aagtcaattt cttagacatt gtttactcct ttttatataa attacttgcg acatgaggct
    27601 gcctcgtcga tcatacgagg caagacgagt tagtactgcg tctagctcag gcactctagt
    27661 gctgagcgtg gggcagtccg actgtaagga ggtttctgcc actgatgcag tgaaatgtta
    27721 atttctcaga cattgaatac tccttaataa aaaataattt cttgcgacac gagtctgcct
    27781 cgtcgattat acgaggcaag acgagttagt actgcgtcta gctcagcacc ctagtgctga
    27841 gcgtggagca gtccgactgt aaggaggttt ctgccactga cgcagtgaaa tgtcaatttc
    27901 ttagacattg tttactcctt tagtttttat atttcttttt caattaattt ctgctgaaca
    27961 aaccaatcta acaagggaaa agttttttct gtatttgccc ataaatgata agaatctaag
    28021 accgcttgta cactacctaa attttctacc aacttatcta ctgtcaaaaa gctgcgccag
    28081 tattcataaa aaatacttgc atagttctta tcataagtcg aagaaccaaa atcattcaat
    28141 gaatgccaac catacttctt ctgaaaaagt tctacgagag attgattaca aattttttcc
    28201 gcttgaaatt cctcttctgt caagaaatac ttgcgactaa tatattcaac catcccctct
    28261 tcgaaccaga tataagagtc ataaccatca aaatcatcta aaaaatgctc cgaccaatga
    28321 gctaactcat gtcctacaat ctgtaagagg aaattttcag ataaagaatg atagtgactt
    28381 tctattgctt gagtttgctg agaacactcg tagtccatca attgatacaa atacaactct
    28441 ttccaaacag ctaaatcagg cgccataacc attcgtctat tatttgtata ggctggaaca
    28501 gcgctttccc taataatctg tgtagcagca ttaaaatctg accaaataac ggcttgcggt
    28561 aaatcacaga ctgcaagttc attctttaaa aaagattgat aatctttcaa cttttcagta
    28621 tttcttacta caaaatcacg aaatgtagct agttgactat cgtcttttac aagataaagg
    28681 ttgtccacgg ctctcctttc tttcacacaa tagactgaat aagcaaaaga accacatctg
    28741 acaatcctag gttgatttaa cctaggggcg tcagaaacgc ggttccaccc taatttatta
    28801 cttcattgtt tttgaaaata ctacagaaag cgccagctca ttattttgcc ctacttggct
    28861 cccactatcc caagctcgct tgaagaacgc cataagactt tctttcttgc tgactattat
    28921 atcaaaaatt agaataatgt acaattcttt ttatgatttt ctagaaatcc acatcatcaa
    28981 ctcgtggagc acccgattga acagcaatcg tttttaaggt ttctctctcc tcatgactca
    29041 gttcaattcc aaagcaatca agattagctt gaatacgaga ggttgtgaca gattttggaa
    29101 gtggtaaaaa tccttctgcc aagctccagg ccaaggctat ctgagcaatc gattttccgt
    29161 gatttgctgc gatttcttgc acttgcttgc tatcaaatag ttctccctga ccaaaaggcc
    29221 cccaagcttc caataaaatt cccttttcac gacagtaagc tacgacttga tcttgataca
    29281 cacctggcgc caagcgaact tgattgaccg caggaacgat agttgcagtt tcaagcaagg
    29341 catccaaatg atggggaaga aaattgctaa cgccgatagc acggattttc ccttcttgat
    29401 agaggtcttc catcgctctc caaacttccg cattgcgagt tttccatgcg tcattttctc
    29461 tgagcggttt tgggttcggc caatgaatca aatacaaatc caaataatcc aagcccagtt
    29521 tttctataga tttttccaaa gcttgacgag tttgctcata ggtttgctga ctattccaaa
    29581 gcttggtagt tacgaacatt tcttcacgtg gaactccgct atctttgatt gcttgaccaa
    29641 cactttcttc attctgataa atcgccgccg tatcaatatg acgataacca gccttcaagg
    29701 cttctaacac tgcacgatag gcttcttctc catccttagc cttaaaagtt ccaaatccca
    29761 atactggaat ttctactcca ttatttaatt gataggtatt catatgcttc tccttctatt
    29821 ttattcatca attatagcat aaaacatttt ttaagtagta ctatcttctg taaaaaataa
    29881 gtctgtcaaa tatctaacag acctattttt tcttgcttat tcatcacgac tatagtacag
    29941 ctcatgagct tttaggcgag tattgagcat ctctggtatg gtcacaaagg tataaccttg
    30001 atttttcaaa tactcaatga cccttggcaa ggcattgact gtcggactgt gaatatcatg
    30061 catcaaaacg atagagccgt tagctacttg atgctgaatt tctgtcaaaa tagatgcttc
    30121 atttttactc ttccagtcca gactatccac atcccacatg ataaagctca aatccaagct
    30181 attgcgaata tcatctgtaa tagcaccata aggtggacgc atgagtttag aactagaacc
    30241 cagcacttta gttagcacat cctcagtatc agtaatctgc tttttagctt catcaagaga
    30301 gagttgcgag agaatcggat ggctccaact atggtttcca acaacatgac cttcagattt
    30361 tatcctcttc accaagtcct cattcccaga aacatttttc ccaagcacaa agaaagtcgc
    30421 tttaatatca tatttagcta gggtctctaa tacctgcggg gtcgttgctg gatttggacc
    30481 atcatcaaag gttagagcga caactttttg atatttctta tcaaagtaag attggtacaa
    30541 ggccgcatct ttttcgagta agtacgaaga ttggataaca tcaaagaaag cagatactgg
    30601 caaggctatc tcttctaaat tttcaaccac aggacttgga taaaggataa tctgactatc
    30661 cttgtaatca aaattccatg cagacaagtc ttggtcagag aagtttttta caatctgctc
    30721 actctggtct tgctctattt ttttatcctc tatgaaggag gtcaactctt ttatcagctg
    30781 ttccttagcc ttactagcat ctgaaaacag ttggtcaagt gtaaaaggtt gcccatcttc
    30841 tgttaagtga acctttccta gactggtctt ttcagtctct tcaaccttaa aagcaactaa
    30901 atcatagatt tgtttggtca cattacgatt aacgactccc tttaaacctg actcttcttg
    30961 ctctgtatag tagaaaacaa gattgtcctt actttctagc ttgtccttaa catcttgatt
    31021 tatcaactcc ctaacagagg aaatcacttt ctccccttgg agaggataat aggcaatcac
    31081 ttcggcttgc ccctgacgaa aatgctcctt ctgatttccc tcactcaatt gatcatcttt
    31141 ctcttttttg agcgattcaa tcttttgctc aaaacttttt tgctggtaga tcttaaaagc
    31201 aataaatccg cctaataggc aaatagaaat tgctaaaata ccaatcaaag ccaataatac
    31261 atgtctcgtt ttcccgtgtc tgccacgtcc tagtctactt ttattcatat ttatatcata
    31321 acaaatttga gcaataattt caatgataca atttggcaat ccacaattcc tctagcaagc
    31381 caaagcatct tacatcaact ccaacatccg tatctgtaga gattatgtag ttttctatct
    31441 atggaatttc tagtagattg aagctagaat agtagaccta tacttctaaa acattgttag
    31501 aaatcgattt gattgtcctg atcgatttgt cctgttctca tttcatttta ctataaaact
    31561 atgaaaagct aggtcatctg agaagtaatt actatcgaca attgcgatag cgtatactgg
    31621 tgcgatttgt ttgtagctct ggtgggtatc accttcacgt tggcgaattt tttctaggtt
    31681 ttgattaacc tgactgcaca gataagccca taggcgattg atgaaaaaat tctgatgatg
    31741 aacctgaatt tcgatgataa cttggattcc attatctaac tccgccaaga cgtctatact
    31801 agtatagaaa tcctgcgctg agtagggcat ggaaggcaag acgtgaatgt tacttccctc
    31861 caaaatcgtc acattttttg ctggcaagtc cagcatatcg cggataaatt gacaaatcat
    31921 tagttgggct gatacccgga tgtctgagaa tcctcctttt cctccttcta ttatagcaca
    31981 tttttaaatc taggtttgct agattctatg cttctatcta tttattcgga aaagaaagct
    32041 tttcttcaga agaaagctaa tagcttattt gaaattttct cctctctgtt ggatagtccc
    32101 gtctatctat gttataatga aagaaggatt taaaatcgga aaaggagtat ttatgctaaa
    32161 attaggtgtc atcggaactg gcgctatcag ccatcatttc atagaagcag cccataccag
    32221 tgaagaatac caactggtcg caatctattc tagaaaacta gaaactgcag caacctttgc
    32281 ttctcgctat cagaatatcc aactattcga tcaattagaa gtcttcttca aatcttcttt
    32341 tgatttagtc tatatcgcca gtccaaactc cttacatttt gctcaggcaa aagctgcctt
    32401 gtctgctggt aaacatgtta ttctcgaaaa gccagctgtc actcaaccac aagaatggtt
    32461 tgatttgatt caaacagctg aaaaaaataa ctgttttatc tttgaagcag ctcgtaatta
    32521 ccacgagaaa gcctttacta ctatcaaaaa ctttttagca gataagcaag tgttaggagc
    32581 agatttcaac tatgccaaat actcttccaa gatgcctgac ttgttgactg gacaaacacc
    32641 aaatgtcttt tcaaaccgtt ttgctggtgg agccctcatg gatttgggga tttatcccct
    32701 ctatgctgct gttcgtcttt ttggaaaagc caatgacgcg acttaccatg ctcaacagct
    32761 tgataatagc attgacctaa atggagatgg tctcctcttc tacccagact atcaagttca
    32821 catcaaggct ggaaaaaaca tcacttccaa tcttccttgc gagatttata caacagatgg
    32881 aaccttgact ctcaacacga ttgagcatat tcgctcagct atttttaccg accaccaagg
    32941 aaatcaagtc cagcttccta tccaacaggc tcctcatacg atgactgagg aagtcgctgc
    33001 atttgcacac atgatccagc aaccagatct gaatctctac caaacttggc tgtatgatgc
    33061 aggctctgtt catgagctac tatataccat gcgccagact gctggcatta gatttgaggc
    33121 agaaaaatga aaaccaaact accgactgaa tggcaagaac tgagtgacca actcggtttc
    33181 caagaattca cccccattca aactcaacta tttgagcccc ttcttgctgg agaaaacctc
    33241 ctaggagtga gccaaaccgg aactggtaag accctagcgt atctcctacc aagtcttctc
    33301 agactacaaa agaaaaaagc ccaacaactc ttgattctag caccaaatac ggaacttgct
    33361 ggacagattt ttgatgtatg taaaacgtgg gcagaagcta tcggattgac tgctcaactc
    33421 ttcctttcag gttcaagtca gaaacgacaa attgaacgtc ttaaaaaggg gccagaaatt
    33481 ctgattggaa ctcctggccg tatctttgaa ctcattaaac ttaaaaaaat caagatgatg
    33541 aatgtggaaa ccatcatcct ggatgaattt gaccaattac tagatgattc tcagattcac
    33601 tttgtagaaa aaatcactca ctacgcacct cgtgaccacc aactggtcta catgagtgcc
    33661 acgaccaagt ttgaccaaga aaagattgta ccgaatacac gcactattga tctctctgat
    33721 caaaaattgg acaatatcca gcatttctac atgcaggtag accaacgtca tcgagtggat
    33781 atgctacgaa aactggctca tgtagaggat ttccgtggtc tagtcttctt caatagcctg
    33841 tcagaccttg ggaatgccga ggaaaaacta cagtatcgtg atatattggc tgtttccctc
    33901 gctagtgatg ttaatgttaa atttagaaaa atcatcttag aaaagtttaa agataaccaa
    33961 ctaaccctgc ttcttgcaac tgaccttttg gctcgtggaa ttgatatcga tagcctagaa
    34021 tgtgtcgtaa actttgatat tcctagagat agcgaaacct acacacaccg tgctggccgt
    34081 actggtcgta tgggcaaaga aggttatgtt atcactctcg tcactcatcc agaagaaatc
    34141 aaaaaactta aaaagtttgc aagtatccga gaaattgtcc taaaaaacca agaactctat
    34201 atcaaataaa gccccattgc tctatacaca tccagtgtat gaagcttttt tataagcaat
    34261 tcaattttat actcatctgc tttcaaaaag cattctagtc catttccgat taacaatgga
    34321 ctttatcacc tccttctcca gttctt
//
LOCUS       DAVHSO010000018        33750 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.018, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000018 DAVHSO010000000
VERSION     DAVHSO010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33750)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33750)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33750
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.018"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(367..1347)
                     /locus_tag="VVR18_000833"
     CDS             complement(367..1347)
                     /locus_tag="VVR18_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetylxylan esterase"
                     /protein_id="HEU6032391.1"
                     /translation="MKNPALLEEIKTYRGRDEVPEDFDAFWDGEVKNVSTLPSYHLEE
                     RDFHIPQVKCYELTFEGSKEGKVYARIVLPKSEEKVPLIFHFHGYMGRGWDWADMLGF
                     TVAGYGVVSMDVRGQSGYSQDGLRSPLGNTVKGHIIRGAMEGRDHLFYKDVYLDIYQL
                     VEIVASLSQVDEKRLSSYGASQGGALALVAAALNPRIQKTVAIYPFLSDFRRVIEIGN
                     TSEAYDELFRYFKFHDPFHETEEEIMATLAYIDVKNLAHRIQGEVKMITGLDDDVCYP
                     ITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYNWLCGSEIPFKYLK"
     gene            complement(1664..3679)
                     /gene="recG"
                     /locus_tag="VVR18_000834"
     CDS             complement(1664..3679)
                     /gene="recG"
                     /locus_tag="VVR18_000834"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HEU6032392.1"
                     /translation="MNLHQPLHVLPGVGPKSAEKYAKLGIENLQDLLLYFPFRYEDFK
                     TKQVLELEDGEKAVLSGQVVTPASVQYYGFKRNRLRFSLKQGEVVFAVNFFNQPYLAD
                     KIELGATLAVFGKWDRAKASLTGMKVLAQVEDDLQPVYRLAQGISQASLVKVIKTAFD
                     QGLDLLIEENLPQSLLDKYKLMSRCQAVRAMHFPKDLAEYKQALRRIKFEELFYFQMQ
                     LQMLKSENRVQGSGLVLNWSQEKVTAVKASLPFALTQAQEKSLQEILTDMKSDHYMNR
                     LLQGDVGSGKTVVAGLAMFAAVTAGYQAALMVPTEILAEQHFESLQNLFPNLKLALLT
                     GSLKAAEKREVLETIAKGEADLIIGTHALIQDGVEYARLGLIIIDEQHRFGVGQRRIL
                     REKGDNPDVLMMTATPIPRTLAITAFGDMDVSIIDQMPAGRKPIVTRWIKHEQLPQVL
                     TWLEGEIQKGSQAYVISPLIEESEALDLKNAIALSEELTTHFAGKAEVALLHGRMKSD
                     EKDQIMQDFKERKTDILVSTTVIEVGVNVPNATVMIIMDADRFGLSQLHQLRGRVGRG
                     DKQSYAVLVANPKTDSGKDRMRIMTETTNGFVLAEEDLKMRGSGEIFGTRQSGLPEFQ
                     VADIIEDFPILEEARKVASYISSIEAWQEDPEWRMIALHLEKKEHLD"
     gene            complement(3698..4801)
                     /locus_tag="VVR18_000835"
     CDS             complement(3698..4801)
                     /locus_tag="VVR18_000835"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000648075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HEU6032393.1"
                     /translation="MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAY
                     GHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFT
                     LTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVCVE
                     GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVR
                     MGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIA
                     TVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKPYPLGTKVTLIGSNG
                     DKEITATQVATYRVTINYEVVCLLSDRIPREYY"
     gene            complement(4791..5159)
                     /locus_tag="VVR18_000836"
     CDS             complement(4791..5159)
                     /locus_tag="VVR18_000836"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000061844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HEU6032394.1"
                     /translation="MRMIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLK
                     GRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLS
                     ISHTDQFVTASVILEENHES"
     gene            complement(5198..6229)
                     /locus_tag="VVR18_000837"
     CDS             complement(5198..6229)
                     /locus_tag="VVR18_000837"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEU6032395.1"
                     /translation="MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGED
                     DRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLV
                     HQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGAR
                     SVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPL
                     AHVILRGAVNEYGNYMPNYYYENLLQAIERYETMGLENPFILIDTNHDNSGKQYMEQI
                     RIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEVFGCSITDPCLGWENTEALV
                     EEIYVTLTK"
     gene            complement(6231..7262)
                     /locus_tag="VVR18_000838"
     CDS             complement(6231..7262)
                     /locus_tag="VVR18_000838"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000232189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEU6032396.1"
                     /translation="MVFTAKSSKINIEEVRALSKLEGQALERKSQRDQELEAIIRGED
                     QRILLVIGPCSSDNEEAVLEYAKRLAVLQEEVADRIFMVMRVYTAKPRTNGDGYKGLI
                     HQPNATEAPSLINGIKAVRHLHYRVITETGMTTADEMLYPENLPLVDDLISYMAVGAR
                     SVEDQQHRFVASGAGFSTGFKNPTSGNLNVMFNGIYAAQNKQSFLFLGKEVETTGNPL
                     SHAILRGALNEYGKNIPNYYYDNLIDTIAQYEKMGLENPFIIIDTNHDNSGKQYIEQI
                     RIVRQTLINRAWNEKIKQFVRGFMIESYLEDGRQNEPEVFGKSITDPCLGWDNTEALV
                     REIYKTLGE"
     gene            complement(7343..9856)
                     /gene="secA"
                     /locus_tag="VVR18_000839"
     CDS             complement(7343..9856)
                     /gene="secA"
                     /locus_tag="VVR18_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HEU6032397.1"
                     /translation="MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAK
                     TVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRT
                     GEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKS
                     PMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEAR
                     TPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLE
                     NLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGL
                     HQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIP
                     IPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKL
                     VAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCV
                     IGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSE
                     EAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYTQRYDVITADRDL
                     APEIQAMIKRTIGRVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAI
                     KEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLR
                     GYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRN
                     IAAHQASMPEDLDLSQIGRNELCPCGSGKKFKNCHGKRQ"
     gene            complement(10002..10289)
                     /locus_tag="VVR18_000840"
     CDS             complement(10002..10289)
                     /locus_tag="VVR18_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000940707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032398.1"
                     /translation="MAHLKSFITRYSKVYIGLVLLIWLSFFFIPWDRAILGVRIDIFI
                     IQKVLLVFGILSILMALLSKKVSLFVFGLICCLSLWINLFITFAILPIFGN"
     gene            complement(10300..10950)
                     /locus_tag="VVR18_000841"
     CDS             complement(10300..10950)
                     /locus_tag="VVR18_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6032399.1"
                     /translation="MRLEIINGQKIYGKRPILNQLNLVFQSGKIYGLKGDNGSGKTVL
                     LKILAGYIKLDKGKVLQDGKVYGVKNHYIQDAGILIEKVEFLSHLSLRENLELLRYFS
                     SKVTEKRIAYWIQYYDLQEFEDVEYRHLSLGTKQKMALIQAFISSPSILFLDEPMNAL
                     DEKSVRLTKQVILSYLKKENGLVILTSHISEDISDLCTDVLVVENGHIQYVKDIQS"
     gene            complement(10954..11595)
                     /locus_tag="VVR18_000842"
     CDS             complement(10954..11595)
                     /locus_tag="VVR18_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032400.1"
                     /translation="MFKNFNNIWLKRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFF
                     KRELISIFSYNDYSEANLEIPKLLLNLSLFMVGWLSVILLESDLADHYHHLIRYQSSS
                     FFDYTRKRLVVISKFFTQDLFVWFLGLLPLGIHFKTVALFFLLAQLMMLYLLLSYLIA
                     LISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLVLLSLLVMLILSRLEEKFKKG"
     gene            complement(11588..12379)
                     /locus_tag="VVR18_000843"
     CDS             complement(11588..12379)
                     /locus_tag="VVR18_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032401.1"
                     /translation="MKIPLLTLARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDL
                     AKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIG
                     REVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIVTYFFGTFSPLGWNSLFSDGSGLQR
                     LLDGEIKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAITYLMFLWLGSMLLYSA
                     LPYYMVPMTSLMQASYGDVSLMKLFTPYILYVVPYMVLEKYEDNV"
     gene            complement(12564..12899)
                     /locus_tag="VVR18_000844"
     CDS             complement(12564..12899)
                     /locus_tag="VVR18_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032402.1"
                     /translation="MEHLFKMIILLPCFYFFSWIDKDNRESKFFPIFYYFYWIYIPLY
                     ALFSLSWTVFSVLFFNIVLRNLTDIKLWGIWLLLLLIAFASDWLDYICFKKMLDLRRE
                     LGKSKGGRH"
     gene            complement(13039..13374)
                     /locus_tag="VVR18_000845"
     CDS             complement(13039..13374)
                     /locus_tag="VVR18_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032403.1"
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWIYIPFY
                     SLFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQE
                     LGKSKGGRH"
     gene            complement(13465..14775)
                     /gene="der"
                     /locus_tag="VVR18_000846"
     CDS             complement(13465..14775)
                     /gene="der"
                     /locus_tag="VVR18_000846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HEU6032404.1"
                     /translation="MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYA
                     TGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEY
                     VARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIV
                     ENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFT
                     DTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDK
                     RIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQ
                     RLHKLPGMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKP
                     PTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     gene            complement(14789..15502)
                     /locus_tag="VVR18_000847"
     CDS             complement(14789..15502)
                     /locus_tag="VVR18_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="HEU6032405.1"
                     /translation="MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQ
                     SYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFVGDLNRAEKGARLHTDTFQPQGVE
                     GLLISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFGMAL
                     GVPNQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQ
                     FGQAEPSSTRKNLKQKKLL"
     gene            complement(15499..16395)
                     /gene="dnaI"
                     /locus_tag="VVR18_000848"
     CDS             complement(15499..16395)
                     /gene="dnaI"
                     /locus_tag="VVR18_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HEU6032406.1"
                     /translation="MESVGDVLKRQPSRFHYQDLVQKIMKDPDVAAFVQQESLNQDEL
                     NRSISKFNQYITERDKFLRGDTDYIAKGYKPILVMNHGYADVSYEETPELIAAEKEAA
                     IKKRLNLINFPSSLKNVSFLDVYRDDVQRLTVLKRMIEFVNDYPNNLKGLYLYGDFGV
                     GKSFMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAIGDGNVKTLVDEIKLSEVLILD
                     DIGAEQSTAWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKGKNGNDETWEA
                     RRVMERIRYLAEETRLEGVNRR"
     gene            complement(16396..17565)
                     /locus_tag="VVR18_000849"
     CDS             complement(16396..17565)
                     /locus_tag="VVR18_000849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation and membrane attachment
                     family protein"
                     /protein_id="HEU6032407.1"
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISF
                     WDNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLALHAPLSSQD
                     FLEHPVYRRLLEKKIGDSAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKK
                     VANDFDLEHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVI
                     STKRMREKIAQKPVSSDFSLKETTIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQ
                     QMAGLGLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEKAVLRIRER
                     GQKTKTQKQNQTAPAKTNIPKWSNPEYKNTSSAEELEEMERQTLELLAKLDNGGD"
     gene            complement(17566..18039)
                     /gene="nrdR"
                     /locus_tag="VVR18_000850"
     CDS             complement(17566..18039)
                     /gene="nrdR"
                     /locus_tag="VVR18_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HEU6032408.1"
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERV
                     EERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENE
                     IQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            18179..18544
                     /locus_tag="VVR18_000851"
     CDS             18179..18544
                     /locus_tag="VVR18_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU6032409.1"
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEA
                     GVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTH
                     FGYEKEELPGVVSDYIKGV"
     gene            18549..19244
                     /locus_tag="VVR18_000852"
     CDS             18549..19244
                     /locus_tag="VVR18_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032410.1"
                     /translation="MSLLAFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTT
                     LIKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYK
                     DFNLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPA
                     ARAYILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESG
                     ESIDQLFRQEFKA"
     gene            19261..20028
                     /locus_tag="VVR18_000853"
     CDS             19261..20028
                     /locus_tag="VVR18_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032411.1"
                     /translation="MFWNLVHYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYK
                     ESQATMLLFLATVFGGLMLTLAISTIFLIIKRFKGSVYDRQGYLTLTLPVSEHHIITA
                     KLIGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLN
                     TISGILCIYLAISIGQLFNEYRTALAVAVYIGIQIVIGFIELFFNLSSNFYVNSLVGL
                     NDHFYMGAGIAIVEELIFIAIFYLGTYYILRNKVNLL"
     gene            complement(20381..21580)
                     /locus_tag="VVR18_000854"
     CDS             complement(20381..21580)
                     /locus_tag="VVR18_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032412.1"
                     /translation="MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGS
                     SMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSV
                     LKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEA
                     KENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYA
                     RMMALFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISL
                     FMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAAGDNLLLKIGSYIPF
                     ISTFFMPFRTINGYAEGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTF
                     KRALSYK"
     gene            complement(21577..22470)
                     /locus_tag="VVR18_000855"
     CDS             complement(21577..22470)
                     /locus_tag="VVR18_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032413.1"
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIF
                     HSILKFLEYQGEIGLDGQDIRQEIYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDA
                     KEVKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLD
                     PVNTELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQ
                     YGKTRLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIA
                     TFDQQAPTIDEIFKLESGVEV"
     gene            22587..22667
                     /locus_tag="VVR18_000856"
                     /pseudo
     CDS             22587..22667
                     /locus_tag="VVR18_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            23152..23365
                     /locus_tag="VVR18_000857"
                     /pseudo
     CDS             23152..23365
                     /locus_tag="VVR18_000857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            23780..24397
                     /locus_tag="VVR18_000858"
     CDS             23780..24397
                     /locus_tag="VVR18_000858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HEU6032414.1"
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQS
                     KETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGI
                     VIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADF
                     LCMLAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(24717..25604)
                     /locus_tag="VVR18_000859"
     CDS             complement(24717..25604)
                     /locus_tag="VVR18_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEU6032415.1"
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKT
                     IEFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPM
                     YFTTDVNSSAYGEMVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHY
                     YVARHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGETIELNNPVWDVQAYYI
                     AQAAVNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAV
                     AGNGSATLGNFVLAKEVSK"
     gene            complement(25753..27636)
                     /locus_tag="VVR18_000860"
     CDS             complement(25753..27636)
                     /locus_tag="VVR18_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEU6032416.1"
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEV
                     IENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQ
                     RAIRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPG
                     LVVWSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGS
                     VLPAFIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYI
                     LIATKAILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAA
                     MTAQGAATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAG
                     AIGGGLASILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYE
                     DEVDATAAAKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQG
                     IAVKPSQGVVYAPADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKV
                     AQGDKVKAGDVLGTFDSNKIAAAGLDDTTMLIVTNTGDYASVAPVATGSVAKGDAVIE
                     VKI"
     gene            28013..29467
                     /locus_tag="VVR18_000861"
     CDS             28013..29467
                     /locus_tag="VVR18_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEU6032417.1"
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGL
                     LNDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLVHFRETGIKVLPDTPLDS
                     HGAYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPAD
                     STDHFRDPQIFNFKGQYYAVVGGQDLEKKGFVRLYKAVNNDYTNWQAVGDLDFANDRT
                     AYMMECPNLVFVEEHPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQ
                     LQNMDYGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDHFDHQGTFSLVKELTIKDD
                     KLYQYPVAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSIN
                     FDLVNGQVTVDRSQAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVF
                     SGRVFPHADQNGILIKSGNPTGTYYELDYGRKTN"
     gene            29448..30413
                     /locus_tag="VVR18_000862"
     CDS             29448..30413
                     /locus_tag="VVR18_000862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU6032418.1"
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMREL
                     GYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDS
                     EKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAG
                     GVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKE
                     MEIKNILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQ
                     LATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(30449..31723)
                     /locus_tag="VVR18_000863"
     CDS             complement(30449..31723)
                     /locus_tag="VVR18_000863"
                     /EC_number="1.1.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA reductase,
                     degradative"
                     /protein_id="HEU6032419.1"
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTV
                     ADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFT
                     AQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
                     QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMAILSNYATDSL
                     VTASCRIAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIAT
                     GNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPR
                     VALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGA
                     SESEVAPLVERLISDKTFNLETAQRYLENLRS"
     gene            complement(31723..32895)
                     /locus_tag="VVR18_000864"
     CDS             complement(31723..32895)
                     /locus_tag="VVR18_000864"
                     /EC_number="2.3.3.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="HEU6032420.1"
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSI
                     APLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFA
                     RSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
                     LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQK
                     RYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGN
                     IYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLN
                     KLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            complement(33026..33274)
                     /locus_tag="VVR18_000865"
     CDS             complement(33026..33274)
                     /locus_tag="VVR18_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032421.1"
                     /translation="MVSSSGSEFQSGWQEHQLIAEKVSKTLDKTFDKDVREIPTSQFY
                     QKFVDEMGRTYSGNLILQELITVNGAYKATYIGELSSN"
     gene            complement(33342..>33750)
                     /locus_tag="VVR18_000866"
     CDS             complement(33342..>33750)
                     /locus_tag="VVR18_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6032422.1"
                     /translation="KKKCHAMKAQAIVTSQGRIVSLDIAVNYCHDMKLFKMSRRNIGQ
                     AGKILADSGYQGPMKIYPQAQTPRKSSKLKPLIAEDKAYNHALSKERSKVENIFAKVK
                     TFKMISTTYRNHRKRFGLRMNLIAGIINHELGF"
BASE COUNT         9881 a         7524 c         6391 g         9954 t
ORIGIN      
        1 aagacgaagc tgacgtggtt taaagagatt tttgaaaagt attaacacct acagacaagc
       61 ctgacgatag caagaactac cctactcgat aggtatcggc ttttgctttc tgaaaaaaat
      121 tattttaagc aatttgacaa atctagcaac aaaaaattct ataaatataa tagattgaaa
      181 ctagaatagt acacatttgc ttctaaaaca ttgttagaaa tcgatttgac tgtcctgatc
      241 aatttgtcct gttcttgttt cattttacta tatttccatg ataaaacgca tagtatcaag
      301 ttttcttaag cccctgatac tatgcgtgtt tgtaattttt aagattttgt gcttagagtc
      361 gactccttat tttaaatatt taaaaggaat ctcacttcca cagagccagt tgtagacttg
      421 gtcattgaca aatacattca tggcttcgtg agcatactca ggcatgatgc gataggtttt
      481 atcgcaggtc agacgattat aaatcgcaaa ctgggtaatg ggatagcaaa catcgtcgtc
      541 caagcccgta atcatcttaa cctcaccttg gatacgatgg gcaagatttt tgacatcgat
      601 ataggcaagg gtcgccatga tttcctcctc tgtttcatgg aaggggtcgt gaaacttgaa
      661 ataacggaaa agttcgtcgt aagcctcgct agtattacca atctcaatca cccgtctgaa
      721 gtctgacaag aagggataaa tggcaactgt tttctgaatt cgaggattga gcgctgctgc
      781 aactagagct agagcccctc cttgtgaggc accatagcta gaaagacgct tctcatcaac
      841 ctgagacaga ctagcaacaa tttcgaccaa ctggtaaata tccagataaa catccttata
      901 aaagaggtgg tcccgacctt ccatagcacc acggataata tgccccttca cggtatttcc
      961 taaaggagaa cgcaagccgt cttgtgagta acctgactgg ccccgcacat ccatggaaac
     1021 aacaccgtaa ccagctacgg tgaagcccag catgtcggcc cagtcccagc cacgtcccat
     1081 ataaccatga aaatggaaga ttagtggaac cttctcctca ctctttggaa gaacaatgcg
     1141 tgcatagacc tttccttcct tgcttccttc aaatgttaac tcatagcact tgacttgagg
     1201 aatgtggaaa tctctttcct ccaagtggta ggatggaagc gtggaaacat ttttcacttc
     1261 cccatcccag aaagcatcaa agtcttccgg aacctcatcc cttcctctat aggtcttaat
     1321 ttcttctagc aaagctggat ttttcatagc atgctccttt tattttgtaa tcgttaccac
     1381 aactgtagca tatctatgta atcaatgcaa gaaagaagga taaatagaaa gtgaatttag
     1441 attctttact tttaggatga tgggctgaaa gtagttttag aaacgaaaaa agagcatttc
     1501 gctctctctt ctgtttatac tagttttttg cttccttctt ttggaaagtg gtttggtaat
     1561 ttactttaat cgttactgtc atatgagagt cctcgtttct ttttgatgac tttagtataa
     1621 gagccaaatc taaaaactag cttaagtttt ccttagagaa agcttaatcc agatgttctt
     1681 tcttttccag atgaagggca atcatgcgcc actctggatc ttcttgccaa gcttctatag
     1741 aactaatgta gctagcaacc tttcttgctt cttctaaaat cggaaaatct tcgataatat
     1801 cagccacttg gaactctgga agtcctgact gtctggttcc aaaaatctca ccagaaccac
     1861 gcattttcaa atcttcctcc gcaaggacaa atccattggt cgtttctgtc atgatgcgca
     1921 tgcggtcttt cccagaatcc gtcttgggat tggcaacgag aacagcgtag gactgcttgt
     1981 ccccccgacc gacacgacct ctaagctggt gaagctggct gagcccgaag cgatcggcat
     2041 ccatgataat catgacagtc gcattgggaa cgttgacccc aacctcaata accgtcgtcg
     2101 aaaccagaat atccgtcttt ctctccttga aatcctgcat gatctggtct ttttcgtcac
     2161 tcttcatcct accatgtaga agagccacct ctgccttgcc tgcaaaatga gtcgtcaact
     2221 cctctgataa ggcaatggca tttttcaaat ctagagcttc tgattcttca atcaaaggag
     2281 agatgacata ggcttgggaa cctttttgaa tttccccctc taaccaagtc aagacctgag
     2341 gtagttgctc atgtttgatc cagcgcgtca caataggctt ccgacctgct ggcatctggt
     2401 cgataatgga aacatccata tctccaaagg ctgtgatggc aagcgtccgt ggaatgggag
     2461 tcgccgtcat catgaggaca tctggattgt cacctttttc ccgtaaaata cgcctttgcc
     2521 ctacaccaaa acggtgctgc tcatcgataa taatcaaacc aagacgagca tactccaccc
     2581 catcttgtat cagagcgtga gttccgataa tcaaatcagc ctcacccttg gcaatggtct
     2641 ccaagacctc tctcttttct gcagctttca aggaacctgt caagagagcc agtttcaaat
     2701 tgggaaaaag gttctgtaaa ctctcaaagt gttgctctgc gaggatttct gttggtacca
     2761 ttagggcagc ctgataacct gctgtcactg ccgcaaacat ggccaagcca gcgactaccg
     2821 tttttccgct ccccacatct ccttgtagga gacgattcat gtagtggtcg gacttcatat
     2881 cagttaaaat ttcctgcaaa ctcttttcct gagcttgggt cagggcaaaa ggaagacttg
     2941 ctttaactgc tgtcactttt tcctgagacc aattcagaac cagaccactt ccctgaactc
     3001 tattttcaga cttgagcatc tgcagctgca tttggaaata aaagagttcc tcaaacttga
     3061 tacggcgaag agcctgcttg tattctgcca aatcctttgg aaaatgcata gctcggactg
     3121 cctgacaacg ggacatgagt ttgtatttgt ctagtaaaga ctggggcaga ttttcttcta
     3181 tcaagaggtc cagtccctga tcaaaagccg tcttgatgac cttgaccaga ctggcctgac
     3241 tgattccctg agccagacga tagacaggct ggaggtcatc ttctacctga gccagaacct
     3301 tcatcccagt cagactagcc ttagcgcggt cccattttcc aaagacagca agggttgctc
     3361 ccaactctat tttatcagcc agatagggct ggttaaagaa attcaccgca aaaacgacct
     3421 ctccctgctt gagactaaaa cgcaggcgat tgcgcttgaa accataatac tggacactag
     3481 caggagtcac tacctgacca gaaagaactg ccttctcacc gtcttccagc tccagcacct
     3541 gcttggtttt gaagtcttca taacggaaag gaaagtagag caagagatct tgcaagtttt
     3601 caattcctag tttggcgtat ttttctgctg actttggtcc cacaccaggc aagacatgca
     3661 agggttgatg tagattcatg ctccactcct ttcttttcta ataatattct ctcggaatac
     3721 ggtcgctgag gaggcaaacc acctcatagt taatggttac gcggtaggtc gctacctgag
     3781 ttgcagtgat ttccttatcc ccattggagc caatcaaggt taccttggtt ccgagtgggt
     3841 aaggcttagg caatcgaata gtgatttggt ccatcgaaac cctgccgaca attgggcaag
     3901 cttggccatc taccaagaca gagaaatttt gcatgtctct tgtccatcca tctgcatacc
     3961 cgattggcac ggtcgcgatg acttgctcgc tatccgcttg ataagttgct ccatagccca
     4021 tgcaagctcc agctggaact gtcttgacat gaaccagagc agactccaag gtcaaggccg
     4081 gtatcaaatc ataaggcaaa tccaagaccg ctccacttgg attgaggcca tacatggcat
     4141 ctcccatacg aaccgcattg aaaatagtct ctacatgcca aagagtcgtt gcagaattgc
     4201 tagcatgaac cagctctgga acttccttca tactagctaa aatagtttta aaccgttcta
     4261 actgggcatt aaaatagtca tctgattcct catcagcagt agcaaagtgg gtaaagattc
     4321 cttcaacaca aacaccgtgt tgttggagca aatcttgagc ctgctcaacc tcacttgcct
     4381 ctctaaaacc aatccgtccc atccctgaat caatcttgag gtggactgtc aatccagtta
     4441 ggtccacttc cttatctaag agtgcttgaa tccactccag tccagccact gtcaaggtga
     4501 agtcatattc tttagctaga gcaacagctt cgatttcaga aactcctaaa atgaggattg
     4561 gcttgctgag tccagcttgt ctgagttcaa tggcttcatc gatattggaa acgcaaaagc
     4621 catcaacatc atcttgaatt gccttggcaa cggcaacagc tccatgacca taagcattgg
     4681 ccttgaccac agccaacttg agcgttcctt gagggatatg agcccccatt tgctgaatat
     4741 tttgtcgaat agctcccaga tgaatcagag ccttggttgg tctatgtgga ctagctttca
     4801 tgattttcct ccaaaatgac actggctgtc acaaactgat cggtgtggct gatagacagc
     4861 caaatctttc ctgaaaatgg tgcctgacta aaataaggcg ccccacgttc attgttcaag
     4921 acttccaaat cctgaaaacc gagcttgcta atgcccgttc ccatagcctt ggaaaaggcc
     4981 tccttagccg accagcgacc agctaaatat tctatttgcc tgcgtccttt gagactggtg
     5041 aagcgctcca tttcctgagc ggtcagtaca cgcttagcaa atccttcatg tcgtgtaact
     5101 gcgctttcta tcgaagccaa ttcttcgatg tcaattccgt gtccaactat cattctcatc
     5161 aaaaggagtt gagattcccc aactccatcc ttttcactta ttttgtcaag gtaacataaa
     5221 tctcttctac caaggcctct gtattttccc aacctaggca agggtcagta atagagcaac
     5281 caaagacctc tggttggttt tgacgaccat ctgctaggta agattcaatc ataaatcctc
     5341 gaaccgtctt tttaattttc tcattccaat cacgattctg caaggtctgg cgaacaattc
     5401 gaatctgctc catatattgc ttgcctgagt tatcatggtt ggtgtcaatg aggataaaag
     5461 gattttcaag tcccatggtt tcatagcgtt caatggcttg gagtaggttt tcatagtagt
     5521 aattcggcat ataattgcca tactcgttga ctgctccacg gaggataaca tgggccaaag
     5581 gattacctga tgtctcaact tcctgcccat gataaaggaa ggtttgcttg ttttgagcag
     5641 catagatggc gttaaacata acacccaaat ttcctgaggt tggatttttc atccctactg
     5701 gtgcatcaat cccagaagcc acaaagcggt gctcttggtc ttccacagaa cgagctccaa
     5761 cggcatggta gctgaccaag tcatccacca agatcagatt tgacggataa agcatctcat
     5821 ctgccgttgt caaaccagtc tctgtaatca cgcggtagtg caactggcgc acagcctgca
     5881 agccgttaat caggcttgga gccttagaag tatctggctg gtgaactaat cctttatagc
     5941 cgtctccatt ggtacgaggc ttagcagtat acacgcgcat gaccatgaaa atcttatccg
     6001 ctaccttctt ttgcaaggcg gataaacggc gagcatattc caagaccgcc tcttcattat
     6061 cagaagagca aggaccaatc accaagagaa tacggtcatc ttcccctgaa ataatatctg
     6121 ccaattccct gtcacggctt tccttgagtc tcaaggcttc cgcagacaat tgggtttcag
     6181 ccttgatgac ttccatatcg atttcttgac ctttttcaat aaatgccatc ttattctcct
     6241 aacgttttgt aaatttctct gacaagagct tctgtgttat cccaacccag gcaagggtct
     6301 gtgatagact taccaaatac ttctggctca ttttgtcgac catcttccag ataagactca
     6361 atcataaaac cacgaacgaa ctgcttaatt ttttcattcc aagcacggtt aatcaaggtc
     6421 tggcggacaa ttcggatctg ttcaatatac tgcttaccag aattgtcatg attggtatca
     6481 atgatgataa aaggattttc caaacccatt ttctcatact gggcaatggt atcaattaaa
     6541 ttgtcataat agtagttggg aatatttttt ccatactcat taagagcacc acgaagaata
     6601 gcgtgtgaaa gcgggttccc agttgtttct acttcttttc ctaagaaaag gaaactttgt
     6661 ttgttttgag cagcataaat cccattaaac atgacattga gatttccaga ggttggattt
     6721 ttaaaaccag tagaaaatcc tgccccactt gccacaaagc ggtgttgctg gtcttcaact
     6781 gaacgggcac caactgccat gtaagaaatc aaatcatcta caagcggaag gttttcagga
     6841 taaagcattt catcagcagt tgtcatccct gtttctgtga tgacacgata gtgaagatgg
     6901 cgaacggctt tgattccatt gataagacta ggcgcttctg tcgcgttagg ctggtgaatc
     6961 aagcccttat agccatctcc gttggtacgg ggtttggcag tataaacacg cataaccata
     7021 aagatacgat ctgccacttc ttcttgtagg actgccaaac gcttagcgta ttcaaggaca
     7081 gcttcttcgt tgtcagatga gcatggcccg attaccaaga gaattcgctg gtcttctcca
     7141 cgtataatgg cttctagctc ttgatctcgc tgtgatttcc tctccaaagc ctgaccttct
     7201 aattttgaca aggcacgaac ttcttctata tttattttag agctttttgc tgtaaatacc
     7261 ataactcatc tccttataaa gcaaacggat acccagtaaa aatttacttt tcacaagata
     7321 tccgcctcta aactatctca ttttattgtc ttttaccgtg acagttttta aatttcttac
     7381 cagaaccaca tgggcaaagt tcattgcgtc caatctggct caaatccaaa tcttctggca
     7441 tacttgcttg gtgagcagcg atattgcgag tcgctgttgt actgatatga cgttctgcct
     7501 gtggtctttc ttgttcatga atttgtgctt tcatcatcaa gcgtgtcaca tcaaactcaa
     7561 tcgaaccaat catatcatta aacatacgga aaccttctgc ctgatactca acaacagggt
     7621 tgttctgagc atagccacga agtccaaccg cgttacgcaa ttgatcaagg gcatcgatat
     7681 gatctgtcca cttgttatcc accactcgta gaatcaaaac tttttggaat tctttaactg
     7741 cttcttcatc gcgtagtttt gaaacctgac tatcgtaaac cttcaaggca cgttggaaaa
     7801 gctcttcctt gatggcctta tcagacaagc ctgacaagtc ttccatcgta atagaatctt
     7861 caggaagcaa gttgtactta gcgaagttca aaattgcctc tagtttctca tcttgtttag
     7921 cacgcgcatg accgtcaacg acacgaccaa tcgtgcgttt gatcattgcc tgaatttcag
     7981 gtgccaagtc acggtctgca gtaatgacat cataacgttg agtatagata atctcacgtt
     8041 gttcacgcat gacatcgtcg tattgaagga cttgtttacg ggtatcgtag ttatttcctt
     8101 cgacacgttt ttgcgctgct tcaacctgac gcgtcaacat gcgagactca atcgcctctt
     8161 cagacatgtt gagacgttca aagattccct tcaagcgttc agaaccaaaa cgtttcatca
     8221 aatcatcttc aagagatagg tagaattgtg actcacctgg atctccttga cgacctgaac
     8281 gtccacgaag ctggttatcg atacgacgac tttcatgacg ttctgtacca ataacacaaa
     8341 gtcctccaag ttcacgaaca ccttcaccaa gcttgatgtc ggtaccacga cccgccatgt
     8401 tggttgcgat ggtaacggca ccacgttgac cagcattcat gatgatttgg gcttctctat
     8461 agtggttttt ggcattcaag acttcgtgag gaacaccagc tgcaaccaat ttcttagaaa
     8521 tgtagtcact agtttcaacc gctactgtac caaccaagac aggttgaccc ttttggtaac
     8581 gagccttaac gtcttcgaca accgctttaa acttagattc gatacttgca taaagaaggt
     8641 ctgagtggtc aatacgttga acaggacggt ttgttgggat tggaataaca cgaatgttgt
     8701 agatttcacg aaattcttct tcctcagtct tacctgtacc cgtcatacca gacaattttt
     8761 tgtacatacg gaaaaggttt tggtacgtga ttgaggcaga tgtcttggtt tcatcctgga
     8821 ttggcacacc ttctttggct tcaatagctt ggtgcaatcc atcagaataa cgacgacctt
     8881 ccatggtacg acctgtaaat tggtcgacaa tcaagatttc ttgctcttcg ctcaccacat
     8941 agtcaatatc gagaagcatg atgtagttgg cacgaagggc gttatcgata aagtgggtca
     9001 aagccacgtt ttcgatgtca tagaggtttt caagtttgaa gtagctttca gccctgtcaa
     9061 tccctgaatc agacaaacca atagtcttag actgcacatc gatgatgtag tcatctttgt
     9121 tcaaagattt tacatagtgg tctgccatgt gatacaactg actggtttca accgcattgg
     9181 cacctgatac aatcaaaggt gtacgagcct cgtcaatcaa gatagagtca acctcatcga
     9241 ccaaggcata gttaagcgga cgttgtacca tgttttcagc gcgaacaacc atattgtcac
     9301 gaaggtagtc aaatccgatt tctgagttag ttgagtaagt aatatcacac tcataggctt
     9361 cttttttctc cattggagat ttggtagcca agttaatccc tactgacaaa ccaagccaag
     9421 agtacaattc acccatctca gtcgcgtcac gttctgacaa gtattcatta accgtaacta
     9481 cgtgaacccc tttacctgaa agggcattga ggtataccgg catggtcgca gtcaaggttt
     9541 tcccttcccc tgtacgcatc tctggcacgt caccatggtg aagaacaatc ccccccatga
     9601 cctgaacctt ataagggaag agacctagga cacgtttggc accctcacgg acaaccgcaa
     9661 atgcttcata aagcaatgaa tccagtgatt ctccattttg ataacgttct ttaaattcaa
     9721 ctgttttcgc ttttaattgg tcatcagtca aagcagccat ttggtcttca tatttgaaaa
     9781 ccttgtcagc catcttttcc agacgacgga tttctccttt atcattttcg ataattgttt
     9841 ttaaaatatt agccatgttt ttccttactt taaattccga atattttaga atgttccttt
     9901 aattttagca caattactga ttattttcaa ggaagaatcc ccattttgaa aaggaaaaag
     9961 aggttagttt tcaagctaac ctctccgact tttatgactg tttaattgcc aaaaatcggc
    10021 aaaatggcaa atgtgataaa taagttaatc caaagagaaa gacagcaaat cagtccaaaa
    10081 acaaagagac tgactttctt ggacagcaag gccatcaaaa tggacagaat tccaaaaact
    10141 agcaagactt tctgtatgat gaagatgtca atccttaccc ccagaatcgc tctatcccaa
    10201 gggataaaga agaaagacag ccagatcagc agaactaaac caatataaac cttggaatag
    10261 cgtgtaataa atgattttag atgtgccata agccatctcc taggattgta tatcctttac
    10321 atattgtata tgtccatttt cgacaactaa tacatctgta caaaggtctg aaatatcttc
    10381 cgatatgtgc gacgtcagga taaccagacc attttctttt ttcaggtaag ataaaatgac
    10441 ctgtttggtt aacctcacac ttttctcatc caaagcattc ataggttcat cgagaaagag
    10501 tatagaagga gaggaaataa aggcttgaat caaggccatt ttttgctttg ttcccaagga
    10561 taaatgacgg tattcaacat cttcaaattc ctgtaaatca tagtattgaa tccaataggc
    10621 aattcttttt tccgtaactt tagatgaaaa ataccttaac agttccaaat tttctctcag
    10681 ggataaatga gataaaaact cgactttttc aattaaaatt cctgcatcct gaatataatg
    10741 attttttacc ccgtaaactt taccatcttg aagaactttt cctttgtcaa gcttaatata
    10801 accagcaagt atctttaaaa gaaccgtctt gccagatcca ttatcacctt taagtccata
    10861 aatttttcct gattgaaaca ccaaattcaa ctgatttaaa ataggtcttt tcccataaat
    10921 tttctgtcca tttataattt caagtctcat cgtttatcct ttcttaaatt tctcttccaa
    10981 gcgactaaga atcaacataa ctaataagct taagagtact aaatacactg ttacaatatg
    11041 atccatcatc cattcttgtc ccacaaatgc caaaaaatag agaaaaaaag aaaaaccagc
    11101 gcccgcacta atcagtgcta tcagataaga cagtagtaag tacaacatca ttaactgagc
    11161 aagtaaaaag aaaagtgcga ctgttttgaa atgaattcct agcggaagta aaccaagaaa
    11221 ccagacaaac aaatcttgag taaaaaattt agaaatgaca accaatcgtt tccttgtata
    11281 atcgaaaaag gagcttgatt gatagcgaat caagtgatgg taatggtctg ccaaatcact
    11341 ttcaagtaaa atgacagaga gccatcctac catgaaaagc gaaaggttta acaagagttt
    11401 ggggatttct aaattcgctt cagaatagtc attataggaa aaaattgaaa tcaattctct
    11461 cttgaaaaag ataacagcat cctgcttttg aaccgctgtt gacaatagat ggtttatcaa
    11521 aatcatcatc agaactatac gaagtagtaa aacaatcttt ctctttagcc aaatattgtt
    11581 aaaattctta aacattatct tcatattttt caagcaccat ataagggaca acataaagga
    11641 tataaggagt aaagagtttc atcaaactta catccccata gctagcttgc atcaaactcg
    11701 tcataggaac catatagtaa ggcaaggcac tatagagcag catagaacca agccaaagaa
    11761 acatcaaata ggtgattgcc gaacgagtca cattccccac ataatcaact atttgtaaaa
    11821 aatagattgc attgatgaaa ataccgatta gtaggacaca agtaaagaac aaatagcttt
    11881 ttatctctcc atctaggagt ctttgtaaac cacttccatc agaaaataga gaattccatc
    11941 caagaggaga aaaagtccca aagaaatagg ttacaattgc aattatcagc acagtcacta
    12001 aatatatcaa acaagggata cttgcaactt gcaaagtcaa ctttcttttt aacccttgat
    12061 aactcacttc tcttccaata ctcaatcgta aaactttatt tttcagctca atatattgaa
    12121 aacctagcaa aacaatgatg attggaataa taaatgattg ataaaaacct agattgaact
    12181 ggagaatacg aaaatctaat gctgatttta ataagtcatt tttaattgct tgtccatcga
    12241 atttagctag atcgggcgca tgaatatcaa aaaagaaata agtcatcaaa acatcacgat
    12301 aaaccaaagc aagaaaaagc aaagtaagca agacataaac aaatttatgc cttgccaaag
    12361 ttaagagagg aatcttcata agccacctcc tacaaataga aagtaatata atactcaatg
    12421 aaaatcaaag agcaaactag gaaactagcc gcaagttgct caaagcactg ctttgaggtt
    12481 gtagataaga ctgacgaagt cagttacata tataatccaa ggcgacgttg acgtggtttg
    12541 aagagatttt cgaagagtat aaatcaatgc cttccgcctt tagacttccc tagttcccgt
    12601 ctcaagtcaa gcattttttt gaaacagata tagtctaacc agtcactagc aaaagcgata
    12661 agtagtaata atagccaaat accccataac ttgatatctg tcaaatttct caagacgata
    12721 ttgaaaaaca gaactgaaaa aactgtccaa gaaaggctaa aaagagcata gagggggatg
    12781 taaatccagt aaaaatagta aaaaattggg aaaaatttac tttctctatt atccttgtca
    12841 atccagctga aaaagtaaaa acagggtaat aagattatca ttttaaacaa gtgttccatc
    12901 acaagcctcc ttttttaaat tgttttcttt agtttcgttc tattaaatgt tattaccaat
    12961 ataaaccttg gaatagcgtg taataaatga ttttagaggt accataagcc acctcctaca
    13021 aatagaaacc gatataaatc aatgccttcc acccttagac ttccctagtt cctgtctcaa
    13081 gcgaaacatt tctttgaaac aggaataagt taaccaattc ataccaatag ctagcagaat
    13141 aaaaagaaac caaatgcccc ataacttgat atctgtcaca tttctcaaga cggtattgaa
    13201 aaacagaact gaaacaactg tccaagcaag gctaaaaaga gaatagaagg ggatgtaaat
    13261 ccagtaaaaa taataaaaaa ttggaaaaaa cttactattt ctgttggcct tttcaatcca
    13321 gttatcaaaa taaaagtacg gtgctaaaag taagaattta aacaaatgtt ccatcaccga
    13381 catccccctc cttcttttga tagcgttttc tattatttta ttatatcaaa agaatctgga
    13441 aatgtcattc cagattctac ttttttattt acgctttctt gctatgagat gaatcggtgt
    13501 tccctcaaag acaaaggcct tgcggatttg attttccaag aaacgtaggt aagaaaagtg
    13561 catgagttct tcttcgttga caaagataac aaaggttggt ggtttggttg ccacttgggt
    13621 cgcatagaaa atcttgagac gttttccttt gtctgtcggt gttgggttga tggcaatggc
    13681 atccatgatg acatcgttca agacagctga tggaatacgt gtattttgac tttcgctgat
    13741 ttgcttaatc atcccaggaa gtttgtggag acgttgcttg gttaaagctg atacaaagat
    13801 aatcggtgcg taaggcaggt attggaactg ctcacggata tcttcttccc agtttttcat
    13861 agtgtggtta tctttttcaa gcgtatccca cttgttgacc acgataatca tccctttacc
    13921 agcttcatga gcaaatccag cgatacgctt gtcgtattca cgaatcccct cttccgcatt
    13981 gatgaccatt aagaccacat ctgaacggtc aatagcacgc atggcacgca tgacagagta
    14041 cttctcagta ttttcataaa ccttaccaga cttacgcata ccagccgtat caatcatggt
    14101 aaactcttga ccatctgtat ctgtaaagtg ggtatcaatg gcatcacgag ttgttccagc
    14161 aacaggactg gcaatgacac ggtcttctcc caagatagca ttaatcaagc ttgattttcc
    14221 aacgttagga cgaccaatca agctaaactt aatgacatct ggattttctt cttcatattc
    14281 atttggaagg ttttccacaa tcgcatctag tacatcccct gtaccgattc catggacaga
    14341 tgagataggc agtggttcac ccaaaccgag agcatagaaa tcatagatat catttctcat
    14401 ctcagggttg tccaccttgt tgactgcgag gataactggt ttgtgggtct tataaagctt
    14461 acgagctacg tattcgtctg catcagtaat tccttcctta ccagacacga caaaaacgat
    14521 aacatctgct tcttccatgg caatttctgc ctggtgcttg atttgttcca tgaaaggagc
    14581 atcgacatca tcaattcctc ctgtatcaat catactaaaa gagcgattga gccactcacc
    14641 cgttgcataa atacggtcac gtgtcactcc ttcgacatct tctacaatgg agattcgctc
    14701 accagcgatc cgattaaata gggttgattt cccaacattg ggacgtccta caatggcaat
    14761 agttggtagg gccataattt ctcactttct acaataactt cttctgttta agattttttc
    14821 tagttgagct tggttctgct tggccaaact gttctgctag acgctgactc cagcttgtgg
    14881 tcgcacgcgc tccagcatag tcagcctgaa cacggtcata agcttggatt gcctcagttg
    14941 actgttcttg gtattcttcc tcaaagacaa cattctctag tggcagtctc ggtttcatat
    15001 catgatgttg atttggcaca cccagtgcca tcccaaagac agaataggtg tagtcaggta
    15061 ggttaaagag ctctgccact tcttcagact tgtatcgaac caaaccgata atcacaccac
    15121 catagcccaa gctttcagct gccaacaagg cgttttgtcc agcaagagct gcatcgaccg
    15181 aactaatcaa gagaccttcc acaccttggg gttggaaggt gtcggtatga agtcgggctc
    15241 ccttttctgc tcggttcaaa tctccgacaa agagaaggaa aacagcagac tggcgaatgg
    15301 cttcttgagg taccaattca tacaaggcat ctttcttctc ttgacttcgt accacaatca
    15361 cagagtagga ttggaaattc ttccaagatg atgccatctg ggctgctgtc aaaatctcat
    15421 ttaagtctac ttggggaatt tcttgctctt taaacctgcg cactgaagta tgagccttca
    15481 tcaatttaat ggtttctgtc atcgacggtt tactccttct aaacgagtct cctcagccaa
    15541 ataacggatg cgttccatga cacgtctggc ttcccaggtt tcgtcatttc catttttccc
    15601 tttagcgaaa tgcttctcca aatcttcaaa gttgaagtta gaggtgaaaa aggtcggtaa
    15661 attttcctgc atccgatatt ggagaatgac ctgcaggatt tcatcacgca cccaagcggt
    15721 ggattgctcg gcaccaatat catctaaaat caggacttca gaaagcttaa tctcatccac
    15781 taaggtctta acattgccat caccgatagc atttttgaca tcaatgacaa agctaggata
    15841 gtggaggaga gtggatgata caccacgttt ttctgataaa tcatgagcta gggcagccac
    15901 catgaaactt ttacccacac caaagtctcc atataagtaa agacctttca aattattggg
    15961 gtaatcgtta acaaattcta tcattctttt tagaacagtt aagcgctgaa catcatcacg
    16021 ataaacatct aaaaaactga catttttcag gctagatgga aaattaatta agttgagacg
    16081 tttcttgata gccgcttctt tttcagctgc gattagttca ggagtttctt cataagaaac
    16141 atccgcatag ccatggttca tgactaatat aggcttgtag cctttggcaa tataatctgt
    16201 atctcctcgg aggaatttat ctctctcagt gatgtattgg ttaaacttgg aaatactacg
    16261 gttcaactcg tcctgattga gggattcttg ctggacaaag gccgcaacat caggatcctt
    16321 catgattttc tgaactaaat cttgatagtg aaaacgactt ggttgacgtt tgagtacatc
    16381 tccgacactt tccatctaat cacctccgtt atctaatttt gctaataatt ctagggtttg
    16441 gcgttccatc tcttctaatt cctcagcgga tgacgtattt ttatattcag gattactcca
    16501 tttaggaata ttggtttttg ctggggcagt ctgattctgt ttttgtgttt ttgttttctg
    16561 ccctcgctca cggatgcgca agactgcctt ttctgccgaa tgaatctttt gataggcata
    16621 gtcattggct accttcatgg catatttctc attgatattt gccgaatcga ccttattaaa
    16681 ggtcaataaa agaatgatat tgatgacttc gtccagcaag cccaagccag ccatctgttg
    16741 caagagttct ctttctgttt gggtaatggt tcccttgcgt gtttgcttga tttctgccaa
    16801 gaactgcagg gcagttttac ttttggcttc tttgataatg gttgtttcct taagactaaa
    16861 gtcagaggaa actggttttt gagcaatttt ttcacgcatg cgtttggttg aaataacctg
    16921 agaaacagct gttgacttgg ccaattgata ggtttcaaac caagtccatt tcttctcctc
    16981 ggcaatagca aagaggttta agacatcgga ctgctcatcc gcaaaacgaa gtccatctcg
    17041 agccatcagc tggcgaaaat gttccaagtc aaaatcattg gccactttct tcttgagacc
    17101 aaggtcttct tgactgccta gttctgccaa ttctggaaag acttgattga gtgagacagg
    17161 tatttcttca ccatcagcac tttcaacttt caaatcctcc acagcagagt cgccaatctt
    17221 tttctctaag agtctgcgat aaacaggatg ctccaagaag tcttgactag atagaggagc
    17281 atggagggct agctgataaa catccccctt ttgatagagg gtcaagagat taaaagcaga
    17341 taagattttc aatgatttta tcagtctatc catcccaaag ttgagatgat tgaggatact
    17401 tgaaaaaaga tattcctttc taccattatc ccaaaaactg attgtataaa gataaaggct
    17461 cagtgcctcc tgaccgataa tcgggaggta gcactgtacc agagatgagg tatcttgcga
    17521 cacccgatta ttctttagat aagaaaaacg gtcaattggc ttcatttatc tttccttttt
    17581 ctttttagag gactgggtga tttgttggag caagctctct aactcactga catccttaaa
    17641 actacgatag acactagcaa aacgtacata ggtaatctcg tccaattcag ccaactcctc
    17701 catgacaagt gaaccaatgt cctcactttg aatttcattt tcatttcgac cacggagttt
    17761 ctgttcgata cgattgacta ccatgttgat ttcatcactt gacacaggac gtttctgggc
    17821 tgagcggata atcccattaa agattttatc tctggagaat tgttcccgtg tgccatcttt
    17881 tttaacaacc actaaggttc tttcttctac tcgttcgtag gttgtaaaac ggtgttggca
    17941 ctcgtcgcac tctcgtcttc tacgaatggt gttcccttct tctgcttggc gactatcgat
    18001 aacacttgac ttggtagccc cacattttgg acaacgcatc ctttccctcc ttatcgtttt
    18061 cttttcatta taccattttt taagcgattc ccaaaacaat tcttcttttt gcttgacaag
    18121 ttttttgttt tgttgtatta tttaattaag acaaaaggat aagagaaagg agactaagat
    18181 gtcctggaca tttgacaaca aaaaacccat ctatttacag attatggaga aaatcaagct
    18241 tcagattgtt tcccatacac tggaacccaa tcaacaactt ccaaccgtga gggagctagc
    18301 tagcgaggct ggtgtcaatc ccaataccat ccaaagagcc ttatcagacc ttgaacgaga
    18361 aggatttgtc tacagcaagc gaacaactgg acgatttgtg actaaggata aggagctaat
    18421 cgctcagtca cgcaaacaat tatcagaaga agaattggaa cacttcgttt cctccatgac
    18481 ccattttggc tatgaaaaag aagaactacc aggcgtagtc agtgattata ttaaaggagt
    18541 ttaagcctat gtcattacta gcatttgaaa atgtatccaa atcatatgga gcaacaccag
    18601 cccttgaaaa tgtttctctt gacattccag ctggaaaaat tgtcggcctt cttgggccaa
    18661 acggctcagg aaaaacaacc ctgattaaac taattaatgg cctcttacaa ccagatcaag
    18721 gacgtgtcct catcaacgac atggacccaa gcccagcaac caaggccgtt gtagcttatt
    18781 tgcctgatac gacctatctc aatgagcaaa tgaaggtcaa agaagcccta acctacttca
    18841 agaccttcta taaagatttc aatcttgaac gcgctcatca tctacttgca gacctgggca
    18901 ttgatgaaaa tagtcgtctc aagaaactat caaaaggaaa caaagaaaag gttcaactga
    18961 ttttggttat gagccgtgat gctcgtctct atgttttgga tgaacccatt ggtggggtgg
    19021 atccagcagc ccgtgcttat atcctcaata ccattatcaa caactactca ccaacttcta
    19081 ccgttttgat ttctacccac ttgatttctg atatcgagcc aatcttggat gaaattgtct
    19141 tcctaaaaga cggaaaagtc gtccgtcaag gaaatgtaga tgatattcgc tacgagtcag
    19201 gtgaatccat tgaccaactc ttccgtcagg aatttaaggc ctaagcaaag gagattattt
    19261 atgttttgga atttagttca ctacgaattt aaaaatgtta acaagtggta tttagccctc
    19321 tacgcagccg tgctagtcct ttctgccctc atcggaatac agacacaagg ctttaaaaat
    19381 ctaccttaca aagaaagtca ggctactatg ctactttttc tagctacagt ctttggtggc
    19441 ttgatgctta cacttgcgat ttcaaccatt ttcttgatta ttaaacgctt caaaggtagt
    19501 gtctacgacc gacaaggcta tctgactttg accttgccag tttctgaaca ccatatcatc
    19561 acagccaaac taatcggtgc ctttatctgg tcattgatta gcaccgctgt attggctcta
    19621 agtgctgtta ttattctggc tttaacagct ccagaatgga ttcctctttc ttatgtgatt
    19681 acatttgtag aaacacatct ccctcagatc tttcttacag gtatatcctt cctactaaat
    19741 actatttcag gaatcctctg catctacctg gctatttcca ttggacagct tttcaatgaa
    19801 taccgtacag cactcgctgt tgcagtctac attggtatcc aaatcgtcat tggatttatt
    19861 gaacttttct tcaatcttag ttctaatttc tatgtcaatt cactggtagg actcaatgac
    19921 catttctata tgggagcagg tatagccatt gttgaagaac tcatattcat agctatcttt
    19981 tatctcggaa cctactacat cttgagaaat aaggttaatt tgctttaaat aatttttacc
    20041 tagatatgta acatactcat agaacaaaag agaccaggca aaaagtcttt acaattagaa
    20101 aacgcatagt atcaagtgtt aaaaatcctt gatattatgc gttttttgtg agctgactta
    20161 tttcctttca ctatatcgca aaatgaaata agaacggaac gatgggattt tggaattcaa
    20221 atcaatttat aagaatgttt tagaagtaat attatcctat tccagattca gttcactata
    20281 caattgagtt ttcaagcaac ctgtttacat aatgtgtaca taattaggtt cgtgattcca
    20341 cccttttcac ctttaaaaac ctcgctttcg caaggctctt ctatttataa gataaggcac
    20401 gtttaaaggt tttccaaatc cctaaatcat ccgtttgaag aacgagacta gcatacatgc
    20461 gtccgataaa tcctgttgct accaccgcaa aaatcactgt aatagcaagt gaaatccatg
    20521 cttccgctcc ctccgcatag ccattaatcg ttcgaaacgg cataaagaag gtcgaaataa
    20581 agggaatata agaaccaatc ttcaagagga gattgtcacc agctgcacct agagctgtca
    20641 ctccaaaaaa accacccata atcaaaatca tcaaaggcga caaggctttc cctgagtctt
    20701 caggacgaga aaccatagat cctaggaagg ctgccaagac tacgtacatg aaaagactga
    20761 tcaaaataaa gagcaaggta ttcagtgaga tagcatctcc caagtgatcc aaaataccag
    20821 actgagccaa gaatggcaaa tctttaaaga gcaaaacggc agccagacca cctacaacat
    20881 agatcccaat atgcgttaaa atcactagaa acagagccat catccgcgca tagaaatagt
    20941 gacttgccct tatgctagaa aagacgactt ccataatttt ggtgcctttt tcactggcaa
    21001 cttcctgagc tgttacaccc gcataggtaa tcagaatcat ataaagaaag aatcctaagg
    21061 cacctgctgc aattgtttga ataaactttt tattttcctt ggcttcatca atcttttctg
    21121 tgaattgaat tgtctgcgct aagcgttttt cctgctcttg agacaaggaa gcagttgaac
    21181 gattaagctg attttgcagt tcattgagtg tacctgtaac ctcaaattta attccatttt
    21241 caagcgatgt ttcgccatga taaactgcct ttagaacact atcttcttga tcaatggtca
    21301 aataaccttt taatttttct tctttaattg cttctttggc acttgcttcg tctttatagt
    21361 cgaagttaac accatttaca ttcttcagtc cttctgctac agatggcact gttgtcacta
    21421 ctgccacttt attattttta gccatagaag aaccttggag atgcccaatt cctacagaga
    21481 ttcctaaaaa gaggaacggc gaaatcacca taaagaagaa actccatgac tcgacatgtc
    21541 gaagataggt ttccttgatt acaacccaca tatttctcat acttccactc ctgattctag
    21601 tttaaagatt tcatcgatag ttggcgcttg ttggtcaaat gttgcgatat attgaccttg
    21661 agtcaagatt gggaagagtt cccttccagc gctctcatcc tccaaaatca atttccaact
    21721 gccttgtttg gtcaagctca cctgtttgac atgaggaaga ttttccaatt cttccttgct
    21781 tcgttcactt gaaacaaaga gacgcgtttt cccgtattga ttgcggacat cctgaactgg
    21841 tccgtgcaag accacacggc catctcgaat catcagaata tcgtcacaaa gttcctcaac
    21901 attggtcatg acatggtcag aaaagataat ggttgctccg cgctcttttt cctgaaaaat
    21961 gacttgtttg agcaattctg tattaactgg gtccaatcca ctaaaaggct catccaagat
    22021 aatcaggtct ggttcatgaa tcagagtaat aatgagctga atcttctgct gatttccttt
    22081 tgacagactc ttgattttat ctgtcagctt tccttttact tccaacctct tcatccattg
    22141 agggagtttt tctttgactt ctttggcatc catgcctttt agagtcgcca agtagcgaac
    22201 ttgttcaaga actgtcaatt taggcatgag actgcgttct tcaggcagat aaccaatccg
    22261 agcatagatc tcctgacgaa tatcctgacc atccagaccg atttctccct gatattctag
    22321 gaattttaaa atactatgga aaatcgttgt ttttccagca ccattttttc cgactagtcc
    22381 caaaatacga cctggtcgcg cttgaaagtc aataccaaac aaaacttgct tggatccaaa
    22441 acttttctct agacttctta cttctagcat ctttcacctc cgaaatttct tgcactcatt
    22501 atactccttt ttgatagcct ttacaatgtt ttttgtccat ttttagaaga ctattgctgt
    22561 gtaaaatatg gcctggagca cttttatact caatgaaaat caaagagcaa actaggaagc
    22621 tagccgtaga ctgctcaaag tacagctttg aggttgcaga taaaactgac gaagtcagct
    22681 caaaacactg ttttgaggtt gtggatagaa ctgacgaagt cagtaactat acgtacggca
    22741 aggcgaagct gacgtggttt gaagagattt tcgaagagta ttagtgataa atccattata
    22801 cagcagcaaa cttaatttat accttccgct cctcaactgt ctatttttaa tcctgaattg
    22861 ttatttgagt aagtcctttt tcctcataaa gttttcttcc tctaaaactt ctggaaaaaa
    22921 gcgaatagtt tcagacaaca tttttataag aaacaagttc atctgtcatt tcaagaagga
    22981 gtaatccttt atctactaat ggacggaacg gaattcaacc gcttgtccga tatgttttct
    23041 aaggattata tagtaaaatg aaataaaaac aggacaaata gatcgggaca gtcaaatcga
    23101 tttctaacaa tgttttagaa gtagatgcgt actattctag tttcaatcta ttatatctat
    23161 tatgcacacc actataggat ctaataaaaa tcacaacaag ttcattcata gatggttacc
    23221 tcagggaact aagaaaacga ctacaaagga agtcgcattc atcgaaaagt ggattaacaa
    23281 ctatcctaaa aaatgcttga actacaagtc ccccagagaa gacttctgga tgactaactt
    23341 gaacttgaaa tttagcaata attaattcac catctaacta tatttagtaa ttatttcaga
    23401 actgattaat attaaaatta actaacaatt caaaggattc atactagcca taaattacgt
    23461 ccatcagaga gagactctta ctacttttag attttagtct ttctagcttc agaatacatc
    23521 taaactttag ggaaaatgac tattcgaaag cgcgaatgcc tcaaaattat ctcagataag
    23581 ctattcgaaa cttagaatgc ttttaaattt atggaattgc gattattcga aacctagaat
    23641 gcatataacc tttagttgac agacccattc taagtctcga agggctattc actttctatt
    23701 ccttatcaaa aaagactcat tccccctttc tcctccaaaa tatggtatag tagaaatata
    23761 ctatctatga ggagtttaca tgtcacagga taaacaaatg aaagctgttt ctccccttct
    23821 gcagcgagtt atcaatatct catcgattgt cggtggggtt gggagtttga ttttctgtat
    23881 ttgggcttat caggctggga ttttacaatc caaggaaacc ctctctgcct ttatccagca
    23941 ggcaggcatc tggggtccac ctctctttat ctttttacag attttacaga ctgtcgtccc
    24001 tatcattcca ggggccttga cctcggtggc tggggtcttt atctacgggc acatcatcgg
    24061 gactatctac aactatatcg gcatcgtgat tggctgtgcc attatctttt atctagtgcg
    24121 cctatacgga gctgcctttg tccagtctgt cgtcagcaag cgcacctacg acaagtacat
    24181 cggctggcta gataagggca atcgttttga ccgcttcttt atttttatga tgatttggcc
    24241 cattagccca gctgactttc tctgtatgct ggctgccctg accaagatga gtttcaagcg
    24301 ctacatgacc atcatcattc tgaccaaacc ctttaccctc gtggtttata cctacggtct
    24361 gacctatatt attgactttt tctggcaaat gctttgacac gtaaaaaatc cgtttggttt
    24421 cccaagtgga tttttaaagc gtagattaac tatagcttga tactaaatat actttggtat
    24481 ggaaatcatg catatttttc gatagtgagg cgaggactta cctagccttt ccgccgtgat
    24541 agaaacacct gaaatctaat ggtttcaggt attcggaaac tttgagccta gtgtctcaaa
    24601 gtttaggtat ggaatttcga agaaagtcgc taccgtccgt aatcacttaa ggaaaggctc
    24661 aaaaatattg ttttcaacca caaaatccgt ttggtttccc aagcggattt tgtgctttat
    24721 tttgaaactt cttttgcaag aacaaagttc ccaagtgtgg cagaaccatt tcctgcgact
    24781 gctggcgtca cgatatagtc acgcacatct ggtactggta ggtaaccatt aagaagagat
    24841 gtaaatttct cacggacacg gtccagcata tgttgttgag ccatgacccc tccaccaaag
    24901 acaatcacgt ctgggcggaa agtcactgtc gcattaaccg cagcttgagc gatatagtag
    24961 gcttgaacat cccaaacagg gttgttgagt tcaatagttt ccccacgtac acctgtacga
    25021 gcttccaaac ttggaccagc tgcataacct tctagacatc ccttatggaa aggacaaaca
    25081 cccttaaact ctttttcaat atccattggg tgtctagcaa cataataatg acccatttca
    25141 gggtgaccca caccaccgat aaactcacca cgttggatga cgcctgcacc gatacctgta
    25201 ccgattgtgt agtaaaccaa gttttcgata cgaccaccag cattgttacg ggcaaccatt
    25261 tcaccgtaag cagagctgtt tacgtctgtt gtgaagtaca ttggcacgtt tagggcgcga
    25321 cgaagggcac caagcaagtc tacatttgcc cagtttggtt ttggagtcgt cgtgataaag
    25381 ccataagttt ttgagttttt gtcaatatca atcggcccaa atgaaccaac tgcaagacca
    25441 gcaaggttat cgaattttga gaagaactca atggttttat cgattgtttc gattggagtt
    25501 gttgttggaa attgtgtttt ttctacaacg ttaaagtttt catcaccgac agcacagaca
    25561 aactttgtac cgcccgcttc caagcttcca tataattttg tcatgataaa cctcttgttt
    25621 ttattttctt tattatagca tacttcgaaa gtctaaatgt ctctattttt tagattttcc
    25681 tctgtaaatc ttactatcta ataaaaacga acaaacatgt catttgttcg ttttcacatt
    25741 agagaggatt gattagattt tcacttcgat cacagcatcc cccttcgcaa ctgaacctgt
    25801 tgcgactgga gctactgaag cgtagtcacc tgtatttgta acgataagca ttgtcgtatc
    25861 atcaagtcca gctgcagcga ttttgtttga gtcaaatgtt cccagaacat cgccagcttt
    25921 caccttatca ccttgagcaa cttttgcttc aaaaccgtca ccgttcatag atacagtgtc
    25981 aataccaacg tgaatcaaaa cttcagcacc atttcttgtt ttcaaaccaa aagcgtgccc
    26041 tgttggaaag gcaattgaaa cttcagcatc agctggtgca tagaccacgc cttggcttgg
    26101 tttcacagcg ataccttgtc ccatagctcc acttgagaag actgggtcat tgacatcagc
    26161 aagagcgaca acatcaccga cgataggagt tacaagtgtt tcattttgaa gagctgctgg
    26221 cgcaacttct tctttttctt cagccacttc agcttgtttt gcagctgcag ttgcgtctac
    26281 ttcatcttcg taaccaaaca tgtaagtaag agcaaaacca agggcaaatg atacagctac
    26341 cataagaagg tattgtggaa gttgtccgtt accaacataa agcattgtac cagggatgat
    26401 ggtgatacca ttaccagtac cagcaagtcc aaggatagaa gccaatccac caccgattgc
    26461 accagcaatc aatgaaagga agaatggttt acggaagcgc aagttcaccc cgaagatagc
    26521 aggctctgta atacctagga aggcagaaag agcagccggg aaagcaagtg ttttcagttt
    26581 tggatttttt gttttaacac caaccgcaac agtagcagca ccttgagctg tcatagcagc
    26641 tgtgatgata gcgttgaatg ggttagcatg gtcagcagca agtaattgca cttcaagcaa
    26701 gttgaagatg tgatgcacac ctgacacgac gatcaattgg tgaaccccac caatcaagaa
    26761 accaccaaga ccaaatggca tgctaagaat cgcttttgta gcaataagga tgtagttttc
    26821 aacaacgtgg aaaactggtc caatgacaaa gagtccaagg atagacatga ccaaaagtgt
    26881 cacgaatggt gttaccaaga ggtcaatgac atctggaaca accttgcgga cagctttttc
    26941 aaatttagct ccgacaaccc cgatgatgaa ggctggaaga acggaacctt gcaaaccaac
    27001 aacagggatg aaaccaaaga agttcatcgc tgttacttca ccaccttgag caactgccca
    27061 agcgtttgga agtgagccag agacaagcat cataccaaga acgataccaa cggcaggatt
    27121 tccaccaaat acacggaagg ttgaccacac aaccaaacct ggcaagatga tgaaggctgt
    27181 atctgtcaag atttgtgtgt aagttgcaaa gtcacctgga agtggcattt caagagcgtt
    27241 gaaaagacca cgcacaccca tgaagagacc tgtcgctacg ataactggga tgattggaac
    27301 gaaaacatca ccgaaagtac ggatagcacg ttggaaccag ttcccctgtt tagcaacttc
    27361 tgctttcatg tcatccttag atgatgttgg taagccaagt acaacaactt catcgtacat
    27421 tttgttaact gtacctgtac caaagataat ttggtattgc cctgagttaa agaaagcacc
    27481 ttgaactttt tccaagttct caatcacttc tttattgatt ttctcttcat ctttgaccat
    27541 gacacgtaaa cgagtcgcac agtgggcaac actattgaca ttttcacgtc cgcccaaggc
    27601 atcgatgact ttttttgcaa tttcctgatt gttcatttgc aaaaatctcc ttatataaca
    27661 ttttgttctt gtttgaaagc gattttattc gcccttacga ctattatttt atcatgtttt
    27721 aaaaatatgt caagcgtttt gcataaaaaa tattctatct acttagtggg caagctttag
    27781 attgattgtt tttgactgtt tcatcaggaa tttcttgaaa aataagtttg aaaccttggt
    27841 taaaaagtct tttatttcat tatctttcac attttcgtaa aaatttgatt gatttcctgt
    27901 atttatttta tgataatcgt ttgacagttt tttctctttt ttaatataaa aggcttgcat
    27961 tttttatcga aaacagttac tattaaaagt gataagattt ttggaggaat gaatggaatg
    28021 gacaactgag cgtcgttaca gactttatca agattggacg caagaagaaa ttcaacatat
    28081 aaaggaaaat atggcacaat ctccatggca tactcattac catgttgagc caaaaacagg
    28141 acttctcaac gacccaaatg gcttttctta ctttgatggc aagtggatcc tcttttacca
    28201 gaattttcct tttggtgcag cccacggttt gaaatcttgg gcacagctag aaagtgatga
    28261 tttggttcac tttagagaaa ctggaatcaa agttttacca gatactccat tagatagcca
    28321 cggtgcctac tctggttctg ccatgcaatt tggcgataac ttattcctat tttatacagg
    28381 aaatgttcgc gatgaaaact ggatccgtca cccataccag atcggtgctt tgatggacaa
    28441 ggagggtaag attacaaaga ttgacaagat cttgattgac cagccagcag actctactga
    28501 ccacttccgc gatccacaaa tttttaactt taaaggtcaa tactatgctg tcgtcggtgg
    28561 acaggacttg gagaaaaaag gcttcgtccg tctctacaag gctgtcaata acgactacac
    28621 aaactggcaa gcagttggcg accttgactt tgctaacgac cgtactgcct acatgatgga
    28681 atgtcctaat ctggtctttg tagaggaaca tcctgtcctt ctctactgtc cacaaggatt
    28741 ggataagaaa gttctagact acgataatat ctttccaaat atgtataaga ttggggcttc
    28801 ctttgaccct aaaaatgcca aaatggtaga tgtgtctcaa cttcaaaaca tggattacgg
    28861 tttcgaagcc tatgcaactc aagccttcaa cgctcctgat gggcgtgctc tagcagttag
    28921 ctggcttggt ttgccagatg tttcttaccc atctgaccat tttgaccacc aaggaacctt
    28981 ctctttggtc aaggaactca ctatcaaaga cgacaagctc taccagtatc cagtcgctgc
    29041 tattaaggac cttcgtgctt ctgaagaagc cttctcaaac cgttcccaaa ccaagaacac
    29101 ttacgaactt gaactcaact tggaagctaa tagccagagc gagattgtct tacttgctga
    29161 taaagaaggt aagggacttt caatcaactt tgaccttgta aacggtcaag tgacagtgga
    29221 tcgtagccag gctggagagc agtatgccca agaatttggg acaactcgtt cttgccctat
    29281 cgagaatcag gctactactg ctacaatctt catcgataac tctgtctttg aaattttcat
    29341 caataaagga gaaaaagtat tttctggtcg tgtcttccca catgcggacc aaaatggtat
    29401 cctgatcaaa tctggaaacc caactggaac ttactatgaa ttagattatg gtcgcaaaac
    29461 taactgatgt cgccaaactt gcaggcgtca gtcctactac cgtttctcgg gttatcaata
    29521 aaaaaggata tctatctgag aaaaccatcc aaaaagtcaa tgaagccatg cgagaattgg
    29581 gctataaacc caacaacctg gctcgtagtc tgcaaggaaa atcagctaag ttaatcggct
    29641 tgattttccc caatatttcc aatgttttct atgcagaatt gattgataaa ttggaacatc
    29701 aactcttcaa aaatggttac aagaccatca tctgcaacag tgaacatgat tctgagaagg
    29761 aacgcgaata catcgaaatg ttggaagcca atcaggtgga cggcatcatt tctggtagtc
    29821 acaacctagg aatcgaagac tacaatcgtg tgacagcgcc gattatttcc tttgatcgaa
    29881 acctatcgcc agacatccct gtcgtctcct ctgacaacta tgctggtggg gttcttgctg
    29941 cccaaacctt ggtcaagaca ggtgcccagt ctatcatcat gattacaggg aatgacaatt
    30001 ccaattcgcc aaccggactg cgccacgctg gttttgcatc cgtactccca aaagctccta
    30061 ttatcaatgt ttccagtgac ttttctcccg tcagaaaaga aatggaaatc aagaatatct
    30121 tgacccggga aaaaccagat gccatttttg cttcggatga tttgacagct attctggtca
    30181 ttaaaatcgc tcaagaattg ggcatttctg tcccaaaaga gctcaaggtc atcggctatg
    30241 atgggaccta ctttatcgaa aattactacc ctcaattggc tactatcaag caacctttgg
    30301 aagagattgc ttgtctcact attgatcttc tcttgcaaaa gattgaaggc aaggaagtcg
    30361 ccacaactgg ttacttctta ccagttacac tattaccagg aaaaagtatt taaacacaag
    30421 aaaactcaga ccgattcgtc tgagtttttt atgatcttaa attttcgaga tagcgctggg
    30481 ctgtctctag gttaaaggtt ttatctgaga tgaggcgctc tactagggga gcaacttcag
    30541 attcactagc cccagctagg agagctaggg atttggcctg tagtttcatg tggccttgct
    30601 ggatgcccgt acttaccaag gctttgaggg ctgcaaaatt ttgggcaaga ccgatggaca
    30661 cgataatctg ggctaattct ctggcagaag gatttcctag tagatcatga ctgagagcta
    30721 cacgtgggtt gaggccgata gagccaccct tagtcgctac aggcatgggc agggtcatct
    30781 caccgaccaa ttcttctctt tcaaggtcca gcgtccagca gctaagacct tgatagcgtc
    30841 catctcgact ggcaaaggca tgggccccag cttcgatggc acgccagtca ttaccagtgg
    30901 caatcaaaat cgcatcaata ccattaaaaa ttcctttatt atgagtagca gctcggtaag
    30961 gatcagcctg cgcaaactga ctagccaacg caattttctc cgcaatctct cgtccttgat
    31021 ccttttggcg gctcaagtag cgaaaggcga tgcgacagct tgcagtcacc agagaatcgg
    31081 tcgcgtagtt ggacaggatt gccatgagac tctgtccctg actgagttct tctaagactg
    31141 gtttcaaggc ttccagcatg gtgttgagca tattggcacc catggcttcc tgggtatcga
    31201 catgaatata aacaacgaga aagtctggtt caccttttat ctgctcgaca tgcagatcac
    31261 gcgccccacc tccacgttta acgatagaag gataggcttg attggcaagc tccaagagct
    31321 ccgctttctt gctggcaatc ttctcttgcg ctagtttagg attagcaact tgataaaggg
    31381 ctacctgccc aatcatctgt cgctgatgga cttgtgcagt aaaaccacct gcacgcttga
    31441 tgattttgct ggcatagctg gccgccgcaa ccacagaggg ttcttctgtc acatagggaa
    31501 cggtgtattc ctgaccgttg acaagtacct ccggaaccag tgaataaggc agagaaaaag
    31561 ttcccactac attctcactc agctggtctg ccacagtcac gctcatctgt tcatccttct
    31621 ccagactagc ttgtctctca ggactaagga gcgcctgagc ttttaacagc tcgaggcgct
    31681 cttggtatga ttttttagaa aatccattcc aacttatctt cattattttt caaccttgct
    31741 ataacggcgt tggtggtcga gaatttcaac caaggcaaaa tcttgatttt catagccagc
    31801 aaactgggca gagtttgttt catccaagtt tacttcctca aaaaagacct tttcatagtc
    31861 tgcaacggat agggcagttc gttggttgag cttgttcaag cggtctttat ccaaataagc
    31921 ttcatatcct tcaaccaatt caccactgaa gaactcagcc acagctccac ttccgtaact
    31981 ataaagggcg attttatccc cagctttcaa gctatctgta ttttccaaga gagacaaaag
    32041 tccaaggaaa agtgaacctg tgtagatatt ccccaccttt tgactgtaga gaatagactg
    32101 gtcaaaatgc ttttgtaaga ggtctttttt ctcttgaggc aggctcttat ccatgatttt
    32161 tttcaagcct tttagcgcta atttaggata aggcaagtgg aaacaaacag ccgcaaaatc
    32221 atccaaagta agctggtagc gtttttgata ttcaagccaa gtcgttttca aactatccaa
    32281 gtattgttgg gtagaataga caccatttac ataaggagtt gtcgagtaat ttggtcgcca
    32341 gaaatccatg atgtcacggg tctgagctac attgtcatta ttaaaggcca tcatgcgtgg
    32401 attttgtgta atcaacatag ctacacttcc agcaccttga gttggttctc ctggagtttc
    32461 aataccgtat ttggcaatat cactggcaat gaccaagacc ttggactccg gagaattttc
    32521 cacatgcaat ttggcataat ggagggcagc agtcgctccg tagcaggctt ctttaatctc
    32581 gaaactacga gcaaagggct ggatgcccag caagccatgc acaaagacgg ccgcagcctt
    32641 actctggtca attcctgact cggtagccac aatgaccatg tcaacttctt gtctttcttg
    32701 ctcagttaaa atagagtcac tagcactggc cgccaaggtc acgatgtcct cagttagggg
    32761 cgcaatactc aattccttga gtaagagtcc tttacttaat ttttcagggt caattcccct
    32821 cgcttctgct aagtcttgta atttcaagac atattgactg gtcgcaaaac caatcttatc
    32881 aataccgatt gtcatattta cctctgtttt atcattcatg taaaaaatcg ttctatacta
    32941 ttttatcaca aatggcagta aaagagagaa aaaagacttg attcaccaaa tcaagcctct
    33001 tattggtcat cattttaaag aatgattagt tgctagagag ttcaccgata taagtagctt
    33061 tataagctcc attcacagtt atcagctcct ggaggatcaa atttcctgag taagtccttc
    33121 ccatctcatc tacaaatttt tgataaaact gactggtcgg aatttctctg acatccttat
    33181 caaatgtctt gtcaagtgtt ttactaacct tctcagcaat caattgatgc tcttgccatc
    33241 cactttgaaa ctctgagccc gaactagaaa ccatgactgg gataaacaac aaggtcagta
    33301 gacttacaga caataaggaa agtagtagac ttcctgcaaa actagaatcc tagttcatga
    33361 ttgataatgc cagcaatcaa attcattcgt aatccgaagc gtttacgatg atttcgatag
    33421 gttgttgaaa tcattttaaa cgtttttact ttggcaaaga tgttctcaac cttgcttctc
    33481 tccttggata gcgcatggtt ataagcttta tcttcagcta ttagcggctt gagtttgctg
    33541 gatttacgtg gagtttgtgc ttgaggatat atcttcatgg gcccttgata accactgtcg
    33601 gccaagattt ttccagcttg tccgatattt ctgcgactca ttttgaacaa cttcatatca
    33661 tgacaatagt tcacagcgat atccaaagaa acaattctcc cttgacttgt gacaatcgcc
    33721 tgagccttca tagcgtggca tttcttttta
//
LOCUS       DAVHSO010000019        33118 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.019, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000019 DAVHSO010000000
VERSION     DAVHSO010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33118)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33118)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33118
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.019"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(52..210)
                     /locus_tag="VVR18_000867"
                     /pseudo
     CDS             complement(52..210)
                     /locus_tag="VVR18_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            275..571
                     /locus_tag="VVR18_000868"
     CDS             275..571
                     /locus_tag="VVR18_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000380708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HEU6032423.1"
                     /translation="MDTPDENGYVADNYRITYLEAHIKAMRDAIYQDGVDLLGYTTWG
                     CIDLVSAGTGEMNKRYGFIYVDRDNVGNGALKRSKKKSFYWYKDVIDSNGASIG"
     gene            692..1636
                     /gene="manA"
                     /locus_tag="VVR18_000869"
     CDS             692..1636
                     /gene="manA"
                     /locus_tag="VVR18_000869"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HEU6032424.1"
                     /translation="MSEPLFLQSVMQEKIWGGAKLRDEFGYDIPSEKIGEYWAISAHP
                     NGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAY
                     GLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAG
                     DFFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNI
                     GEPANSRPVTIKADDLRSTLLVSNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQL
                     TVDGKNYPIQKGRHFILPSDVEAWTLEGQDLELIVSHP"
     gene            complement(1627..3132)
                     /locus_tag="VVR18_000870"
     CDS             complement(1627..3132)
                     /locus_tag="VVR18_000870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-dependent transporter"
                     /protein_id="HEU6032425.1"
                     /translation="MVFLTDLRKHNRIVKSINQTEGYLTTQVAFSYFEKGDQSLTMSE
                     KSQWGSKLGFILASAGSVIGLGSVWKFPYMTAANGGGGFLLIFLISTILIDFPLLLAE
                     FALGRSAGVSAIKTFGKLGKNNKYNFIGWIGAFALFILLSFYSVIGGWILVYLGIEFG
                     KLFQLGGTGDYAQLFTSIISNPAIALVAQAAFILLNIFIVSRGVQKGIERASKVMMPL
                     LFIIFVVIIGRSISLPNAMEGVLYFLKPDFSKLTSAGLLYALGQSFFALSLGVTVMLT
                     YASYLDKKTNLVQSGISIVAMNISISIMAGLAIFQARSPFNIQSEGGPSLLFIVLPQL
                     FDKMPFGTIFYVLFLFATVTSSVVMLEINVGNITNQDNSKRAKWSVILGILTFVFGIP
                     SALSYGVMADVHIFGKTFFDAMDFLVSNLLMPFGALYLSLFTGYIFKKALAMEELHLD
                     ERAWKQGLFQVWLFLLRFFVPSFQSSSWSSSPNLCNQKDLSNELRPFLFYG"
     gene            3349..3653
                     /locus_tag="VVR18_000871"
                     /pseudo
     CDS             3349..3653
                     /locus_tag="VVR18_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819367.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family DNA-binding protein"
     gene            complement(3682..4137)
                     /locus_tag="VVR18_000872"
     CDS             complement(3682..4137)
                     /locus_tag="VVR18_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEU6032426.1"
                     /translation="MNRREAVEFVNMCMIKNGDKVLVQDRVSPDWPGITFPGGHVERG
                     ESFVDAVIREVKEETGLIISKPQLCGIKNWYDDKDYRYVVLFYKTEHFTGELQSSDEG
                     KVWWEDFENLSHLKLATDDMSDMLRVFLEEDLSEFFYYKNGDDWLYDLK"
     gene            complement(4157..5332)
                     /locus_tag="VVR18_000873"
     CDS             complement(4157..5332)
                     /locus_tag="VVR18_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEU6032427.1"
                     /translation="MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAG
                     TGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGR
                     VFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIV
                     TTGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFPHKALQGISLDDVTLSY
                     GKHVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKS
                     LKNALKTLLPERLAEFFVQGYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFV
                     TKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGSLHYD"
     gene            complement(5391..6236)
                     /locus_tag="VVR18_000874"
     CDS             complement(5391..6236)
                     /locus_tag="VVR18_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEU6032428.1"
                     /translation="MTWKIIADSGCDYRQLPTPAINTTFVSVPLTIQVADQVFVDDAS
                     LDIDQMMETMYATAEASKSACPSPDDYLRAFEGAENIFLVTITGTLSGSHNSAQLAKN
                     IYLEDHPDTKIHVIDSLSAGGEVDLLVEKLNDLIDQGLSFEEVVEAITAYQEKTKLLF
                     VLAKVDNLVKNGRLSKLIGTVVGLLNIRMVGKASETGTLELLQKARGSKKSVQAAYDE
                     LVKAGYAGGRIVMAQRNNEKCCQQLSERIRETFPQADIKILPTSGLCSFYAEEGGLLM
                     GYEID"
     gene            6361..6918
                     /locus_tag="VVR18_000875"
     CDS             6361..6918
                     /locus_tag="VVR18_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEU6032429.1"
                     /translation="MSERRISEKSLENLRKSNQESNLLTREAIETALLQLLEKKELTK
                     ISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLHHYDLKTDLYLVWVH
                     LFREARKEARVIQLALDYHLEKIFVQAMQEFLEKYHGKSKGVSSYLHSFWSSAIVSVL
                     LKWIKDGMKVPAEKIADLGLPFFKK"
     gene            6937..7404
                     /locus_tag="VVR18_000876"
     CDS             6937..7404
                     /locus_tag="VVR18_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000138511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HEU6032430.1"
                     /translation="MTEKRLAWDEYFAAQALLIANRSTCKRAKVGAILVKDNKVISTG
                     YNGSVSGTEHCIDHECLVIEGHCVRTLHAEVNAILQGAERGVPKGFTAYVTHFPCLNC
                     TKQLLQVGCKRVVYINQYRMDDYAQYLYQEKGTELTHLPLETVQTALKEADLM"
     gene            7493..8122
                     /gene="upp"
                     /locus_tag="VVR18_000877"
     CDS             7493..8122
                     /gene="upp"
                     /locus_tag="VVR18_000877"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HEU6032431.1"
                     /translation="MGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEV
                     LRDLPLEDVEIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGM
                     YRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCL
                     VSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK"
     gene            8296..8886
                     /gene="clpP"
                     /locus_tag="VVR18_000878"
     CDS             8296..8886
                     /gene="clpP"
                     /locus_tag="VVR18_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit
                     ClpP"
                     /protein_id="HEU6032432.1"
                     /translation="MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIA
                     QLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIA
                     SSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
                     SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN"
     gene            8965..9213
                     /locus_tag="VVR18_000879"
     CDS             8965..9213
                     /locus_tag="VVR18_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbG family protein"
                     /protein_id="HEU6032433.1"
                     /translation="MFEKVNRSGLIIYLYYNRDAKKLQDYGDITYHSKKHRYLQLYVP
                     TQEVEQLVGRLSKEKFIKKVRVCHIQELETPFVGNLYR"
     gene            9314..10474
                     /locus_tag="VVR18_000880"
     CDS             9314..10474
                     /locus_tag="VVR18_000880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU6032434.1"
                     /translation="MKKKFALSFVALASVALLAACGEVKSGAVNTAGNSVEEKTIKIG
                     FNFEESGSLAAYGTAEQKGAQLAVDEINAAGGIDGKQIEVVDKDNKSETAEAASVTTN
                     LVTQSKVSAVVGPATSGATAAAVANATKAGVPLISPSATQDGLTKGQDYLFIGTFQDS
                     FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYKGEIVADETFVAGDTDF
                     QAALTKMKGKDFDAIVVPGYYNEAGKIVNQARGMGIDKPIVGGDGFNGEEFVQQATAE
                     KASNIYFISGFSTTVEVSAKAKAFLDAYRAKYNEEPSTFAALAYDSVHLVANAAKGAK
                     NSGEIKDNLAKTKDFEGVTGQTSFDADHNTVKTAYMMTMNNGKVEAAEVVKP"
     gene            10742..11611
                     /locus_tag="VVR18_000881"
     CDS             10742..11611
                     /locus_tag="VVR18_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HEU6032435.1"
                     /translation="MLQQLVNGLILGSVYALLALGYTMVYGIIKLINFAHGDIYMMGA
                     FIGYFLINSFQMNFFVALIVAMLATAILGVVIEFLAYRPLRHSTRIAVLITAIGVSFL
                     LEYGMVYLVGANTRAFPQAIQTVRYDLGPISLTNVQLMILAISLILMILLQVIVQKTK
                     MGKAMRAVSVDSNAAQLMGINVNRTISFTFALGSALAGAAGVLIALYYNSLEPLMGVT
                     PGLKSFVAAVLGGIGIIPGAALGGFVIGLLETFATAFGMSDFRDAIVYGILLLILIVR
                     PAGILGKNVKEKV"
     gene            11615..12571
                     /locus_tag="VVR18_000882"
     CDS             11615..12571
                     /locus_tag="VVR18_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HEU6032436.1"
                     /translation="MKENLKVNILWLLLLLAGYSLISVLVSVGVLNLFYVQILQQIGI
                     NIILAVGLNLIVGFSGQFSLGHAGFMAIGAYAAAIIGSKSPTYGAFFGAMLVGALLSG
                     AVALLVGIPTLRLKGDYLAVATLGVSEIIRIFIINGGSLTNGAAGILGIPNFTTWQMV
                     YFFVVITTIATLNFLRSPIGRSTLSVREDEIAAESVGVNTTKIKIIAFVFGAITASIA
                     GSLQAGFIGSVVPKDYTFINSINVLIIVVFGGLGSITGAIVSAIVLGILNMLLQDVAS
                     VRMIIYALALVLVMIFRPGGLLGTWELSLSRFFKKSKKEEQN"
     gene            12571..13335
                     /locus_tag="VVR18_000883"
     CDS             12571..13335
                     /locus_tag="VVR18_000883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032437.1"
                     /translation="MALLEVKQLTKHFGGLTAVGDVTLELNEGELVGLIGPNGAGKTT
                     LFNLLTGVYEPSEGTVTLDGHLLNGKSPYKIASLGLGRTFQNIRLFKDLTVLDNVLIA
                     FGNHHKQHVFTSFLRLPAFYKSEKELKAKALELLKIFDLDGDAETLAKNLSYGQQRRL
                     EIVRALATEPKILFLDEPAAGMNPQETAELTELIRRIKDEFKITIMLIEHDMNLVMEV
                     TERIYVLEYGRLIAQGTPDEIKTNKRVIEAYLGGEA"
     gene            13335..14045
                     /locus_tag="VVR18_000884"
     CDS             13335..14045
                     /locus_tag="VVR18_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000062217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032438.1"
                     /translation="MSMLKVENLSVHYGMIQAVRDVSFEVNEGEVVSLIGANGAGKTT
                     ILRTLSGLVRPSSGKIEFLGQEIQKIPAQKIVAGGLSQVPEGRHVFPGLTVMENLEMG
                     AFLKKNREENQANLKKVFSRFPRLEERKNQDAATLSGGEQQMLAMGRALMSTPKLLLL
                     DEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNANKALAISDRGYVLETGKIVLSG
                     TGKELASSEEVRKAYLGG"
     gene            14404..15060
                     /locus_tag="VVR18_000885"
     CDS             14404..15060
                     /locus_tag="VVR18_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEU6032439.1"
                     /translation="MAVKDFMTRKVVYISPDTTVSHAADLMREQELHRLPVIENDQLV
                     GLVTEGTIAQASPSKATSLSIYEMNYLLNKTKVKDVMIRDVVTVSGYASLEDATYLML
                     KNKIGILPVVDNHQVYGVITDRDVFQAFLEIAGYGEEGIRVRFVTEDEVGVLGKIVSL
                     IVEENLNISHTVNIPRKDGKVIIEVQIDESIDLPALREKFEANGIQVEEIARTSAKVL
                     "
     gene            15168..16263
                     /gene="prfB"
                     /locus_tag="VVR18_000886"
     CDS             join(15168..15239,15241..16263)
                     /gene="prfB"
                     /locus_tag="VVR18_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511312.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HEU6032440.1"
                     /translation="MDISVIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPD
                     FWNDNIAAQKTSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAE
                     LDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKV
                     EVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVE
                     VMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRT
                     QYGNRDRAMKMLQAKLYQMEQDKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDH
                     RTSFEVAQVDKVMDGDLDGFIDAYLKWRIS"
     gene            16281..16973
                     /gene="ftsE"
                     /locus_tag="VVR18_000887"
     CDS             16281..16973
                     /gene="ftsE"
                     /locus_tag="VVR18_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="HEU6032441.1"
                     /translation="MSIIEMRDVVKKYDNGTTALRGVSVSVQPGEFAYIVGPSGAGKS
                     TFIRSLYREVKIDKGSLSVAGFNLVKIKKKDVPLLRRSVGVVFQDYKLLPKKTVYENI
                     AYAMEVIGENRRNIKRRVMEVLDLVGLKHKVRSFPNELSGGEQQRIAIARAIVNNPKV
                     LIADEPTGNLDPDNSWEIMNLLERINLQGTTILMATHNSQIVNTLRHRVIAIENGRVV
                     RDESKGEYGYDD"
     gene            16966..17892
                     /locus_tag="VVR18_000888"
     CDS             16966..17892
                     /locus_tag="VVR18_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032442.1"
                     /translation="MISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVI
                     FNTAKLATDIENNVRVVVYIRKDVEDNSQTIEKEGQTVTNNDYHKVYDSLKNMSTVKS
                     VTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANTPNDVKTIAEDAKKIEGV
                     SEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMR
                     LVGAKNSYIRGPFLLEGAFIGLLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPD
                     LFSPLMIALLFVIGVFIGSLGSGISMRRFLKI"
     gene            18178..20358
                     /locus_tag="VVR18_000889"
     CDS             18178..20358
                     /locus_tag="VVR18_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000974069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEU6032443.1"
                     /translation="MMKDTFKNVLSFEFWQKFGKALMVVIAVMPAAGLMISIGKSIVM
                     INPTFAPLVITGGILEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINR
                     ITGTIFGVSGDMLKNPDAMVTTFFGGSIKVADYFISVLEAPALNMGVFVGIISGFVGA
                     TAYNKYYNFRKLPDALSFFNGKRFVPFVVILRSAIAAILLAAFWPVVQTGINNFGIWI
                     ANSQETAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYDILTGAAKGTQVFG
                     QDPLWLAWVTDLVNLKGTDASQYQHLLDTVHPARFKVGQMIGSFGILMGVIVAIYRNV
                     DADKKHKYKGMMIATALATFLTGVTEPIEYMFMFIATPMYLVYSLVQGAAFAMADVVN
                     LRMHSFGSIEFLTRTPIAISAGIGMDIVNFVWVTVLFAVIMYFIANFMIQKFNYATPG
                     RNGNYETAEGSEETSSEVKVAAGSQAVNIINLLGGRVNIVDVDACMTRLRVTVKDADK
                     VGNAEQWKAEGAMGLVMKGQGVQAIYGPKADILKSDIQDILDSGEIIPETLPSQMTEA
                     QQNTVHFKDLTEEVYSVADGQVVALEQVKDPVFAQKMMGDGFAVEPANGNIVSPVSGT
                     VSSIFPTKHAFGIVTEAGLEVLVHIGLDTVSLEGKPFTVHVAEGQKVAAGDLLVTADL
                     DAIRAAGRETSTVVVFTNGDAIKSVKLEKTGSLAAKTAVAKVEL"
     gene            20410..21225
                     /locus_tag="VVR18_000890"
     CDS             20410..21225
                     /locus_tag="VVR18_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEU6032444.1"
                     /translation="MKFLTLNTHSWMEKEAEEKFQILLEDILEKDYDLICFQEINQEM
                     TSSEVEVNDLYQALPAAEPIHQDHYVRLLVEKLSEQGKNYYWTWAYNHIGYNRYHEGV
                     AILSKTPIEAREILVSDVDDPTDYHTRRVALAETVVDGKELAVASVHLSWWDKGFQEE
                     WARFEAVLKKLNKPLLLAGDFNNPAGQEGYQAILASPLGLQDAFEVAQEKSGSYTVPP
                     EIDGWKGNTEPLRIDYVFTTKELAVENLHVVFDGNKSPQVSDHYGLNAMLNWK"
     gene            21365..22708
                     /locus_tag="VVR18_000891"
     CDS             21365..22708
                     /locus_tag="VVR18_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU6032445.1"
                     /translation="MSFTKFQFKNYIREALEELKFTTPTEVQDKLIPIVLAGRDLVGE
                     SKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRV
                     VNYVGGTDKARQIEKLASNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLD
                     MGFLETVDKIAGSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTID
                     NWLISTKGHDKNAQIYQLTQLMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDI
                     APRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTG
                     RNGLSGTAITLYQPSDDSDIRELEKLGIKFSPKMVKDGEFQDTYDRDRRANREKKQDK
                     LDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRADRKAKRQTF"
     gene            22923..24113
                     /locus_tag="VVR18_000892"
     CDS             22923..24113
                     /locus_tag="VVR18_000892"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HEU6032446.1"
                     /translation="MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAE
                     TAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSP
                     DIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRL
                     AELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDK
                     VIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFS
                     GKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVA
                     ESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALK
                     EAVK"
     gene            24666..25601
                     /locus_tag="VVR18_000893"
     CDS             24666..25601
                     /locus_tag="VVR18_000893"
                     /EC_number="1.3.98.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate oxidase"
                     /protein_id="HEU6032447.1"
                     /translation="MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVT
                     KTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLV
                     GMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
                     PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGI
                     GGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKE
                     GVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID"
     gene            25635..26672
                     /locus_tag="VVR18_000894"
     CDS             25635..26672
                     /locus_tag="VVR18_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HEU6032448.1"
                     /translation="MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDS
                     ADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSF
                     EEYLDNPSPTTKLIIFAEGKLDSKRRLVKLLKRDAKAFDAVEVKEQELRQYFQKWSQK
                     QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKADSVIEEEDIVNAIPKTLQDNIF
                     DLTQFILTKKMDQARDLVRDLTLQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQI
                     ASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFE
                     KALLQIASQVN"
     gene            26845..27450
                     /locus_tag="VVR18_000895"
     CDS             26845..27450
                     /locus_tag="VVR18_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HEU6032449.1"
                     /translation="MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALE
                     KHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAA
                     IDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQNTPISEGKKPIL
                     GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK"
     gene            27606..28136
                     /locus_tag="VVR18_000896"
     CDS             27606..28136
                     /locus_tag="VVR18_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YutD family protein"
                     /protein_id="HEU6032450.1"
                     /translation="MRKEIAPELYNYNKFPGPEFHLHGDKVETEGIAFSLVENIKDAF
                     DVTTFNQRFSEVLTKFDYIVGDWSNEQLRLRGFYKDDRTEEKLEKISRLQDYLLEYCS
                     YGCAYFVLENEAPKRASFDKKMRKTEEETPSRKGKKPTQTKRKSNADKKNRRRQKDQH
                     SQKEDKGQRHFVIRQK"
     gene            28157..29242
                     /gene="rlmN"
                     /locus_tag="VVR18_000897"
     CDS             28157..29242
                     /gene="rlmN"
                     /locus_tag="VVR18_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000804770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HEU6032451.1"
                     /translation="MKPSIHSLAHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEE
                     MTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLS
                     VCVTTQVGCNIGCTFCASGLIKKQRDLNNGEIVAQIMLVQKYFAERGQDERVSHIVVM
                     GIGEPFDNYNNVLNFFRTINDDKGMAIGARHIMISTSGLAHKIRDFADEGVQVNLAVS
                     LHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDGVEQALE
                     LAELLKNIKKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGVNCVVRQEHGT
                     DIDAACGQLRSNTMKRDRQKAVAAVNP"
     gene            29242..29724
                     /locus_tag="VVR18_000898"
     CDS             29242..29724
                     /locus_tag="VVR18_000898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000976721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HEU6032452.1"
                     /translation="MMKKTYNHILVWGVIFYSICIVYFCFTPQEQSTVGVGTPGIQHL
                     GRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNVLNVFLFFPLIFQLLYLFPNLRKTKK
                     VLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKIRN
                     "
     gene            29726..31267
                     /locus_tag="VVR18_000899"
     CDS             29726..31267
                     /locus_tag="VVR18_000899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002918612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU6032453.1"
                     /translation="MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKST
                     FMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLAERQSVRDVLRTAFDELFKAEARIN
                     DLYMKMAEDGADVDALMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMDTDVT
                     SLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDI
                     PFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVA
                     RNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGY
                     DRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFE
                     QEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRF
                     CLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHEPDFYEGWIDQIWD
                     FNNLT"
     gene            complement(31323..32126)
                     /locus_tag="VVR18_000900"
     CDS             complement(31323..32126)
                     /locus_tag="VVR18_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HEU6032454.1"
                     /translation="MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVA
                     AQSAKELNDALTNENANFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFL
                     THAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
                     LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLD
                     GKHPVFGQVIDGMDVVDKIAKAEKDEKDKPTTAITIDSIEVVKDYDFKS"
     gene            complement(32209..32421)
                     /locus_tag="VVR18_000901"
     CDS             complement(32209..32421)
                     /locus_tag="VVR18_000901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032455.1"
                     /translation="MSFYGLFYNGIAITPNTYLSAWFVNFIAALPLNFLIVEPIARFI
                     LSSFQKPFTGEEVEDFQDDDEIPTII"
     gene            complement(32900..33109)
                     /locus_tag="VVR18_000902"
     CDS             complement(32900..33109)
                     /locus_tag="VVR18_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000953868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032456.1"
                     /translation="MLSVNTILEKFYKEHQVKPFISPERELDTWLLSPKPVPKRNMDL
                     LVDDSLAGDIILLWRIQFGTFTTET"
BASE COUNT        10024 a         6172 c         7214 g         9708 t
ORIGIN      
        1 cttgaaggag agagtcgagt ccgaactcct catatttttt acattttgct aaatcgttgt
       61 ttgattacag tctaaaagct ctataatctc tttataagat ttgcccatca gacgaaatag
      121 aacgatttga aggcgtttat gatatttagc tgtacgagag tcttttaaaa gtgttttgat
      181 ggtttggatt tcttctttag ttgatttcat atcactatta tataatgctt tttgatttta
      241 gtttagtatt atcgtagaaa atggactcgg tgctatggat acaccggatg agaatggtta
      301 tgtagcagat aactatcgga ttacttactt agaggcccac atcaaggcca tgcgagatgc
      361 catttaccaa gacggggttg acttgcttgg ttatacgact tggggctgta tcgatctggt
      421 ttcagctggc acaggggaaa tgaataagcg ctatggcttt atctatgtag atcgagataa
      481 tgtaggaaac ggagctctca aacgtagcaa gaagaagtcc ttctattggt acaaggatgt
      541 cattgatagc aatggtgcaa gcatcgggta gagcacattt gtttactatt tttataaaat
      601 cttctccctg ctttataaga tgtaaaaaag agttcaattc gaactctttt tttgctataa
      661 tgaggggaga aaaatcagac aggagatcga catgtcagaa ccattatttt tacaatcagt
      721 tatgcaagaa aaaatctggg gtggagccaa gctacgtgat gagtttggct acgacatccc
      781 aagtgaaaaa atcggagaat attgggccat ctcagcccat ccaaatggag tctctaaagt
      841 tgccaatggt cgttacgagg gaacagatct tgctactttg tatgcggaac accgtgaatt
      901 atttggcaat cgtccagaac ctgtatttcc acttttgacc aagatcctcg atgccaacga
      961 ctggctcagt gtccaagttc acccagacga tgcttatgga ctcgagcatg aaggcgaact
     1021 cggaaaaaca gaatgctggt acatcatcgc tgcggatgaa ggttcagaga ttatctacgg
     1081 tcacaatgcc aagtcaaaag aagaactccg ccagcaaatc gaggataaga actgggatgc
     1141 gctgttgaca aaagtgccag ttaaagcagg agatttcttc tatgtaccaa gcggtaccat
     1201 gcacgctatc ggggcgggta tcttgattct tgaaacccag cagtctagcg ataccactta
     1261 ccgtgtctat gactttgacc gtaaggatga caagggcaat ttacgtgaac ttcaccttga
     1321 aaaatctatc gatgtcttga acattggtga acccgcaaat agccgtccag tgacaatcaa
     1381 agcagatgat ctacgttcca ctctccttgt atccaatgat ttcttcgcag tttacaaatg
     1441 ggaaattact ggaaaagtta actttgaaaa gacagctgac tacagcttgt tgagtgtctt
     1501 ggctggtcaa ggtcaactaa ctgttgacgg gaaaaactat ccaatccaaa aagggagaca
     1561 ctttatccta ccaagtgatg ttgaagcttg gactctggaa gggcaagatt tagaattaat
     1621 tgttagtcat ccataaaaaa gaaagggcct gagttcatta ctcaagtcct tttgattaca
     1681 taaattgggc gatgaagacc acgatgatga ttggaatgac ggaacgaaga aacgaagaag
     1741 gaagagccag acttggaaca gtccttgttt ccatgctctt tcatcgagat ggagttcctc
     1801 cattgcaaga gcctttttaa agatatagcc tgtaaaaagt gaaaggtaga gagctccaaa
     1861 tggcatgagg agattggaaa ccaagaagtc catagcgtca aagaaggtct taccaaaaat
     1921 gtgaacatcc gccatgacac cgtaagatag ggctgaagga atgccaaaga caaaggtcaa
     1981 aattcctaaa ataacactcc atttggcacg tttgctgtta tcctggttgg tgatattgcc
     2041 cacattgatc tccagcatca cgacagaaga agtgacagtc gcaaagagga agaggacgta
     2101 gaaaatggtt ccaaaaggca tcttgtcaaa gagttgaggc aagacgataa agagcaagct
     2161 cggtccccct tcagactgga tattgaaggg ggatcgagct tggaaaatgg ctagacctgc
     2221 catgatggat atcgagatat tcatggctac gatggagatt cctgactgga ctagattggt
     2281 tttcttgtcc aagtaagaag cataggtcaa catgactgta acccctagtg agagggcaaa
     2341 gaaagattgt cccagagcat agaggagacc agcgctagtc agttttgaaa agtctggttt
     2401 gaggaagtaa agaacccctt ccatggcatt tggcaaactg atagagcgac cgatgataac
     2461 aacaaagatg ataaagagca ggggcatcat gactttcgaa gctctttcaa tccctttttg
     2521 aaccccacgt gatacaataa agatatttaa taagataaag gctgcttgag ctactagggc
     2581 aatggctgga tttgaaatga ttgaagtaaa taactgagca taatcacccg ttccaccaag
     2641 ttggaacaat ttcccaaact caatacctag atagactaga atccatcctc cgataacact
     2701 gtaaaaagat aagaggataa agagggcaaa ggcgccaatc caaccgataa agttgtactt
     2761 gttattcttg cccagttttc caaaggtttt gatagcggaa acgccagcac tacggccaag
     2821 ggcaaactca gccagcagga gagggaaatc gattaaaata gtggaaatga gaaagattag
     2881 taaaaagcct ccaccgccat tagcagcagt catgtaggga aacttccaaa cggaaccaag
     2941 cccgatgacc gagccagcag atgctagaat aaagccaagt ttcgaccccc attgtgattt
     3001 ttctgacata gttaaactct gatctccttt ttcaaaataa gaaaaagcta cttgagttgt
     3061 caaatagcct tctgtttgat tgatagactt gactatccta ttatgttttc taaggtctgt
     3121 caagaaaacc attttcaagt tttcacacct ttctcaaaaa cgcttgactc tgacctaagg
     3181 ggaggggtta tactatcatt gtaaggagga aatcatgtac catataaaag aagctgcgca
     3241 gctttcaggt gtctctgtca agaccctgcc ctgcatcact atgacaagat aggactcttg
     3301 gtccccttaa agtcggaaaa cggctatcga acctatagtc aagaggattt ggaacgcctt
     3361 caggtcattc tttactacaa atatctaggc ttttctttag agaaaataga agagctgtta
     3421 aaggaagaaa ggacagattt attgccccat ttaactaggc agttggacta tctaactcgc
     3481 gaaaggcaac atctggatac cttgatttcc accttgcaaa aaactattca agaacaaaaa
     3541 aaggttacgt ctacaaccca gagtttaagg aaaacattga caagtttggt tctgaaacag
     3601 cccagtacac gtcagatgcc attgcggctt acgttcagac aaatgcagaa taaataggct
     3661 aggaatttcc tagcctattt tttacttcaa atcataaagc cagtcgtcac cgtttttgta
     3721 gtaaaagaat tcactgagat cttcttctag aaacacacga agcatatcag acatatcatc
     3781 ggttgcaagt tttagatgag aaagattttc aaagtcctcc caccaaactt tcccttcgtc
     3841 tgaagactgg agttcaccag taaagtgttc tgtcttgtaa aaaaggacga cataacgata
     3901 atccttgtcg tcataccagt ttttgatacc acagagttgg ggtttggaaa tgatcagacc
     3961 agtttcttct ttcacttcac gaatgacagc atcgacaaag gattcgccac gttcaacatg
     4021 accaccagga aaagtaatgc caggccagtc gggactaact cggtcttgga ccaggacctt
     4081 atctccgttt ttaatcatac acatgttaac aaattcgact gcctctcttc tgttcattct
     4141 tcacaacctt taatctttaa tcataatgca gacttcccgc cacccagccg gtacagaggg
     4201 cagaagtgat gttaaaacca cccgtgtggg cattgatatc cataacttcg cctgcaaagt
     4261 ggaggccagg taccagctta ctttcaaggg ttttaggatt gatttccttg agactgactc
     4321 cacccttggt aacaaaggac tttgcaaggg acatttttcc agttacagga attttaagtt
     4381 ctttaatgga ctggacaagt tgttctcgtt ccttttcagt cagttgtttg actttttcag
     4441 gatatccttg tacaaaaaat tcggccaagc gttctggtaa caaggttttt aaagcgtttt
     4501 tcaaggattt ttcccgattt tcttctagaa atgtaaccaa gtccttctca gaaagttgag
     4561 gcaaaacatc gagtgagaga acctccccac ctttgacaaa gctagacatg cgtagggcag
     4621 caggacctga caaaccaaag tgggtaaaga gtaaatcatg agtgatgaca tgcttaccat
     4681 aacttagggt cacatcgtcc agagaaatcc cttgtaaggc tttatgtgga aaatctgtta
     4741 ataaaggact ttcagcagcc tcaagatcgg tgatggtatg cttaaaatgg cgagcaatct
     4801 cgtgaccaaa accagtcgaa ccagtcgaag gataagactt accacctgtt gtgacaatga
     4861 gtttctcaca agtgaaggtt tgatccgctg acttaaggac aaactggtca tctacttttt
     4921 taacagaaac gatttctatt tgagtagcaa cttgaccacc tagttcggtg attttctttt
     4981 ccaaagcttc gataatagtc cgagacttgt cactggctgg aaagacgcgt ccgtggtctt
     5041 cgaccttaag tttaacacca ttttctgtaa aaaagttgat gatgtcatga ttatcgaact
     5101 gggagaaaac actgtaaaga aagcgtccgt ttccaggaat tccagctagc aggttgtcta
     5161 agctaccatt gttggtcaca ttgcaacgtc ccccaccagt cccagctaat ttttttccaa
     5221 gtttccgatt tttttcgatg aggagggttt tctgtccata aaagctactg gaaatcgtag
     5281 ccatcatacc agcaggtccc ccaccgatga caatagtatc aaaatgtttc atagctctat
     5341 tgtaccacaa aaaaacaaga gatgatggtc acatcttgtc aagaatgcaa ttaatcaatt
     5401 tcatagccca tcagcaaacc gccctcttct gcatagaaac tgcagagacc agaggttggt
     5461 agaattttaa tatccgcttg tgggaaggtt tcacggattc gctctgagag ctgttgacaa
     5521 catttttcgt tattgcgttg ggccatgaca atacggccac cagcatatcc agcttttact
     5581 aactcatcat aggcagcttg aactgatttc tttgatcccc ttgctttttg tagcaattcg
     5641 agagttccag tttcactagc ttttccgacc atacgaatgt tgagaaggcc aacgaccgta
     5701 ccgataagct tgctcaaacg gccgttcttc accaagttat cgactttggc taggacaaag
     5761 agcaacttag ttttttcttg ataggcggtg atagcttcaa ccacttcttc aaaagacaag
     5821 ccttggtcaa tcaagtcatt caatttttct acgagtaggt caacttcacc accagcagat
     5881 aaactatcaa tcacatgaat cttagtgtca ggatggtctt ccagataaat attctttgct
     5941 agttgagcac tattgtgact gccagaaagg gtacctgtga tggttactag gaaaatgttt
     6001 tcggcacctt caaatgctcg caaatagtca tctgggcttg gacaagctga ttttgaagct
     6061 tctgcagttg catacatggt ttccatcatt tggtcaatat cgagactggc gtcatcaaca
     6121 aagacctgat cagctacttg aatggttaag gggacactta caaaggttgt gttaatagct
     6181 ggtgttggca gttgacgata atcacaacca gagtcagcaa taatcttcca agtcatagaa
     6241 attctccatc tttgtcagtt atacattgac aaaggttctg tcttttttta caattatatc
     6301 atgaaaactc ttgaaacaaa agcatcatcc gtctgttgtg acaagtagaa agaaaatgtt
     6361 atgtctgaac gtagaatctc tgaaaagtct cttgaaaatc tcagaaaatc aaaccaagaa
     6421 tccaatttat taaccagaga agccattgaa acagccctct tgcaactctt ggaaaaaaag
     6481 gagctgacca agattagtat ttctgaattg gtcaaacgtg caggtgtttc gcgtgcggcc
     6541 ttttatcgca attatgactc caaagaggaa attttagaga gcgtctttaa acgaactgtc
     6601 cacaatatta tggaacagct gcatcattac gatttaaaga cagaccttta tttggtttgg
     6661 gttcaccttt tccgggaggc cagaaaggaa gctagagtga ttcaattggc cttggattac
     6721 catctggaaa aaatctttgt ccaagccatg caggaatttc tagaaaaata ccatgggaaa
     6781 tcaaaaggtg tcagctctta tcttcattcc ttctggagct cagccatcgt ctctgtcctt
     6841 ctaaaatgga tcaaggatgg catgaaggta ccagctgaaa agattgcaga tttaggttta
     6901 ccatttttta aaaaatagag aaaaaggaga aaagagatga ctgaaaaaag actggcctgg
     6961 gatgagtatt ttgcagccca agctctacta attgcgaatc gttccacttg taaacgtgct
     7021 aaagtgggcg cgattctggt aaaagataat aaggttattt ccactggtta caatggttcg
     7081 gtgtcaggga ctgagcattg tattgatcac gaatgtttgg tcattgaagg ccactgcgtt
     7141 cgcacccttc acgctgaggt caatgctatc cttcaaggtg ctgagcgtgg tgttcccaaa
     7201 ggctttacag cctatgtaac ccattttcct tgtctcaact gtacaaaaca attgcttcag
     7261 gtcggctgca agcgcgtggt ttatatcaac cagtaccgaa tggacgacta cgcccaatac
     7321 ctttatcaag aaaaagggac agaattgacc catttaccac ttgagacagt acagacagct
     7381 cttaaagagg ctgatctaat gtaaaaatta tcaaaaataa atggtttaga aagattttta
     7441 aaccgttttt tggtataata agaagaataa attgaaagaa ggaattccaa aaatgggaaa
     7501 aattgaagtt attaatcacc cactgattca acacaaattg tcaattttgc gtcgtacaga
     7561 tacttctaca aaagcttttc gtgagctagt agatgagatt gcaatgttga tggggtatga
     7621 agtacttcgt gatcttccac tagaagatgt ggaaatcgaa acaccaatta caaaaacagt
     7681 tcaaaaacaa ttggcaggta agaaattggc catcgtccca atcttgcgtg caggtatcgg
     7741 gatggttgat ggtctcttga gcttggttcc agctgctaaa gttggccaca tcggtatgta
     7801 ccgtgatgaa gaaacacttc aaccagttga atacttggtg aaattgcctg aggacattga
     7861 ccaacgtcaa atttttgtag tagacccaat gttggcaaca ggtggctcag caatcttggc
     7921 tgttgattct cttaaaaaac gtggcgcatc aaatatcaaa tttgtctgcc ttgtatctgc
     7981 tccagagggt gtaaaagccc ttcaagaagc tcatccagat gtagaaatct ttacagcagc
     8041 cttggatgaa cgtttgaatg aacacggtta tatcgttcca ggtcttggag atgctggaga
     8101 ccgcttgttc ggtacaaaat aagatcgaaa agaagaatga cttggaaaag tatttctagt
     8161 cacgaaagga ggttgggttt ttgtttctgt ctaatgaaag cagagcaaaa atttgacctt
     8221 ttttgaccaa gatattataa tagtcttatc ttcagtcatt tgaccaacaa aattaaaact
     8281 caaaaggaga aatgaatgat tcctgtagtt attgaacaaa caagccgtgg agaacgttct
     8341 tacgatattt actcacgtct tctcaaagac cgcatcatta tgctgacagg tccggttgaa
     8401 gacaatatgg ctaactctgt tattgcccaa ttgcttttct tggatgccca agatagtacg
     8461 aaagatattt acctttatgt caatacacca ggtggttctg tttcagctgg tttggcaatc
     8521 gtagatacca tgaactttat caaggcagat gtccaaacca ttgttatggg aatggctgca
     8581 tctatgggga ctgtcatcgc atcaagtgga gcaaaaggca aacgtttcat gcttccaaat
     8641 gctgaataca tgattcacca accaatgggc ggtacaggtg gtggtaccca acaaactgat
     8701 atggctatcg ctgcagaaca cttgctcaaa actcgtaata ccttggaaaa aatcttggct
     8761 gaaaattcag gtcagtcaat ggaaaaagtc catgcagatg cagaacgtga taactggatg
     8821 agcgcccagg aaacacttga atatggcttt attgatgaaa ttatggccaa caattcattg
     8881 aactaatgat gatagaaggc aaactcgact gggtttgctt tttttggtat aatagggaga
     8941 gatttcttag aaagaggatt tatcatgttt gaaaaagtca atcgctctgg cttgattatc
     9001 tatctttact ataatcgtga tgccaaaaaa ctgcaggatt atggagatat tacctatcat
     9061 tccaagaaac atcgttactt acaactctat gttccaactc aagaagtgga gcaattggtc
     9121 ggacgcttga gcaaggaaaa atttattaaa aaagttaggg tttgtcatat ccaagagttg
     9181 gaaacaccct ttgtgggcaa tctttatcga taggaaaacg ttatcatcga aaaagttcaa
     9241 ggaaaacatt gacaattttc tgataattcg gtatattctt aacagactat ttaagaaata
     9301 aggagacaaa aagatgaaga aaaaatttgc cctatcgttt gtggcgcttg caagtgtagc
     9361 acttcttgca gcctgtggag aagtgaagtc tggagcagtc aacactgctg gtaactcagt
     9421 agaggaaaag acaattaaaa tcgggtttaa ctttgaagaa tcaggttctt tagctgcata
     9481 cggaacagct gaacaaaaag gtgcccaatt ggctgttgat gaaatcaatg ccgcaggtgg
     9541 tatcgatgga aaacaaatcg aagtagtcga taaagataat aagtctgaaa cagctgaggc
     9601 tgcttcagtt acaactaacc ttgtaaccca atctaaagta tcagcagtcg taggacctgc
     9661 gacatctggt gcgactgcag ctgcggtagc gaacgctaca aaagcaggtg ttcccttgat
     9721 ctcaccaagt gcgactcaag atggattgac taaaggtcaa gattacctct ttattggaac
     9781 tttccaagat agcttccaag gaaaaattat ctcaaactat gtttctgaaa aattaaatgc
     9841 taagaaagtt gttctttaca ctgacaatgc cagtgactat gctaaaggga ttgccaaatc
     9901 tttccgcgag tcatacaagg gtgaaatcgt tgcagatgaa actttcgtag caggtgacac
     9961 agactttcaa gcagccctta caaaaatgaa agggaaagac tttgatgcta tcgttgttcc
    10021 tggttactat aatgaggctg gtaagattgt aaaccaagcg cgtggcatgg gaattgacaa
    10081 accaatcgtt ggtggtgatg gattcaacgg tgaggagttt gtacaacaag caactgctga
    10141 aaaagcatca aacatctact ttatctcagg cttctcaact actgtagaag tttcagctaa
    10201 agctaaagcc ttccttgacg cttaccgtgc taagtacaat gaagagcctt caacatttgc
    10261 agccttggct tatgattcag ttcaccttgt agcaaacgca gcaaaaggtg ctaaaaattc
    10321 aggtgaaatc aaggataacc ttgctaaaac aaaagatttt gaaggtgtaa ctggtcaaac
    10381 aagcttcgat gcagaccaca acacagtcaa aactgcttac atgatgacca tgaacaatgg
    10441 taaagttgaa gcagcagaag ttgtaaaacc ataatagaaa aatgttgaaa tagggaatga
    10501 gcctttgact cactccctgt ttcgatattt aatactcttc gaaaatctct tcaaactgcg
    10561 tcaacgtcgc cttggattat atatgtgact gacttcgtca gtcttatcta caacctcaaa
    10621 gcagtgcttt gagcaacctg tggctagttt cctagtttgc tctttgattt tcattgagta
    10681 taagaaccta tcaaaaagtg agggaaaccc ctcggaatta taaatagaaa gagtgaatct
    10741 tatgctccaa caactcgtaa atggtttgat tctaggtagt gtttacgcgc tgttagccct
    10801 aggatatacc atggtttacg gaattatcaa gctcatcaac ttcgcccatg gtgatattta
    10861 tatgatggga gcctttatcg gttatttctt gatcaattct ttccaaatga atttctttgt
    10921 agcgcttatt gtagctatgc tagcgacagc tattcttggt gtcgtgattg agtttcttgc
    10981 ttaccgacct ttgcgccact ctactcgtat tgctgttttg attacggcta ttggggtttc
    11041 tttcctattg gagtatggaa tggtctatct ggttggtgcc aatacccgtg ccttccctca
    11101 agcgattcaa acagttcgat atgatttggg accaattagc ttaacaaatg tgcagttaat
    11161 gattttggcc atttccttga ttttgatgat tttgttacaa gtcattgtcc aaaagactaa
    11221 gatggggaaa gccatgcgtg cagtatcagt agatagcaac gcggcgcaat tgatggggat
    11281 caatgtaaac cgtacgatta gctttacctt cgctttgggt tctgctcttg cgggtgcggc
    11341 tggtgttctg attgctcttt attataactc tcttgagcct ttgatggggg ttactccagg
    11401 tcttaaatct ttcgttgccg cagtacttgg tggtatcgga attattcctg gtgcggctct
    11461 tggtggcttt gtgattggtc tattggaaac ctttgcgaca gcctttggga tgtcagattt
    11521 ccgtgatgcc attgtttatg gaatcttgtt gttgatcttg attgtccgcc cagctggtat
    11581 ccttggtaag aatgtgaaag agaaggtgta aacgatgaag gaaaatttaa aagttaatat
    11641 tctatggtta ctccttttgt tagctggcta tagcttgatt agtgtactgg tttcagtcgg
    11701 agtacttaat ctattctatg tacagatttt acaacaaatt ggaattaata ttattttggc
    11761 tgttggtctc aacttaatcg ttggtttttc aggacaattt tcacttggtc atgctggttt
    11821 catggcgatt ggtgcctatg cagcagctat tattggttct aaatcaccaa cctacggtgc
    11881 cttctttgga gctatgcttg taggggcttt gctttcagga gcagttgcct tacttgtcgg
    11941 cattccaacc ttgcgcttga agggggacta tcttgcggta gcaactctgg gtgtttctga
    12001 aattatccgt atctttatca tcaatggtgg aagtcttaca aatggtgcgg caggtatctt
    12061 agggattcct aactttacaa cttggcaaat ggtttacttc tttgtcgtga ttacaaccat
    12121 tgcaaccttg aacttcttgc gtagcccaat tggtcgttca accctctctg ttcgtgaaga
    12181 tgaaatcgct gctgagtcag ttggggttaa tacgactaaa attaaaatca tcgcttttgt
    12241 ctttggtgcc attactgcaa gtattgctgg gtcacttcag gcaggattta tcgggtctgt
    12301 tgtaccgaaa gattacacct tcatcaactc aatcaacgtt ttgattattg ttgtatttgg
    12361 tggactcggt tccattacag gtgcgattgt ttcggctatt gttctgggaa ttttgaatat
    12421 gcttctccaa gatgttgcta gtgtgcgtat gattatttac gctttggcct tggtattggt
    12481 aatgattttc agaccaggtg gactccttgg aacgtgggaa ctgagcctat cacgtttctt
    12541 taaaaaatct aagaaggagg aacaaaacta atggcattac ttgaagtaaa acagttaacc
    12601 aaacattttg gtggtctaac agctgttgga gatgtgactc ttgaattgaa cgaaggggaa
    12661 ctggttggat taatcggtcc aaacggagct gggaaaacca cccttttcaa ccttttgacc
    12721 ggtgtttatg aaccaagcga gggaacagta accctagatg gtcacctttt gaatgggaaa
    12781 tcaccttata agattgcctc tttgggactt ggacgtactt tccaaaatat ccgtctcttt
    12841 aaagatttaa cagttttaga taatgttttg attgcttttg gaaaccatca caaacagcat
    12901 gtttttacta gtttcttacg cttaccagct ttttacaaga gtgaaaaaga attaaaggct
    12961 aaagctttgg aattgttgaa aatctttgat ttagatggtg atgcagagac tcttgctaaa
    13021 aatctttcct acggacaaca acgtcgtttg gaaattgttc gtgcccttgc tacggaacct
    13081 aaaattctct tcttagatga accagcagca ggtatgaacc cacaggaaac agccgaattg
    13141 actgagttaa ttcgtcgtat caaagatgaa tttaagatta caatcatgtt gattgaacac
    13201 gatatgaatc tggtcatgga agtaacagaa cgtatctacg tacttgaata tggccgttta
    13261 attgctcaag gaactccaga cgaaattaag accaataaac gcgttatcga agcttatcta
    13321 ggaggtgaag cctaatgtct atgttaaaag ttgaaaatct ttctgtgcat tacggtatga
    13381 tccaagcagt ccgtgatgta agctttgaag ttaatgaagg agaagttgtt tcccttatcg
    13441 gtgccaacgg tgcaggtaag acaactattc ttcgcacctt gtcaggtttg gttcgaccaa
    13501 gttcaggaaa gattgaattt ttaggtcaag aaatccaaaa aataccagct cagaaaatcg
    13561 tggcaggtgg tctttcacaa gttccagaag gacgccacgt ctttcctggc ttgactgtta
    13621 tggaaaatct tgaaatggga gctttcttaa agaaaaatcg tgaagaaaat caagctaact
    13681 tgaagaaggt tttctcacgc tttcctcgtc ttgaagaacg taagaaccaa gatgcagcta
    13741 ctctttcagg aggggaacaa caaatgcttg ccatgggacg cgctcttatg tcaacaccaa
    13801 aacttcttct tttagatgaa ccatcaatgg gacttgcccc aatcttcatc caagagattt
    13861 ttgatatcat tcaagatatt cagaagcaag gaacaaccgt cctcttgatt gaacaaaatg
    13921 ccaataaagc acttgcaatc tctgaccgag gatatgtatt ggaaacagga aaaatcgtcc
    13981 tatcaggaac aggaaaagaa ctcgcttcat cagaagaagt cagaaaagca tatctaggtg
    14041 gctaaaacaa tccagtggat tgttttagtc ggcagatgaa gattacgaag taatcatcaa
    14101 tatagtccgg gggccctttt tagtcggtgg atgaagattg cgaagcaatc atcaaatcca
    14161 gaggattgtt ttagccggta gattgagatt gcaaacaaat ctgcatctac attgaaagct
    14221 taatttctaa taattgaaaa aatcgaatga aaagtttctt accttcattc acagagctcg
    14281 attttagagc tctttttgct agcttattca tacttttcta aattttgaaa aagaaatgta
    14341 agcgtttgat agatttgcaa aaagattgta taatagggat aagaatagaa aaggagaagt
    14401 ctcatggcag ttaaagattt tatgacccgc aaggtagttt atattagtcc agatacaaca
    14461 gtatctcatg cagcagattt gatgagagag caagaattgc atcgcttgcc tgttatcgaa
    14521 aatgatcaat tggttggttt ggtgactgag ggaaccattg cacaagcaag tccatctaaa
    14581 gcaacaagtc tttctatcta tgagatgaat tatcttctga ataagacaaa agtaaaagat
    14641 gtcatgattc gcgatgttgt cactgtctca ggctatgcta gtctagaaga tgcaacttat
    14701 ctgatgttga aaaataagat tggtattctc cctgtcgtag ataaccatca agtatacgga
    14761 gttattactg accgtgacgt tttccaagcc tttcttgaaa ttgcaggtta tggcgaagaa
    14821 gggattcgtg tacgctttgt tacagaagat gaagttggtg ttcttggaaa aattgtttct
    14881 ttgattgtag aagaaaattt gaatatctcc catacagtca atattccgcg taaggatggt
    14941 aaggtgatta tcgaagtgca aatcgatgaa tcaattgatt taccagcctt gagagaaaaa
    15001 tttgaagcaa atggtattca agtggaagaa atcgctcgca cttcagcaaa agtcttgtaa
    15061 gaagggaagt ccaaaggctt cttttttcat gaaaagggga ttagagcaaa agatggaaag
    15121 aaatgataaa atatgctata atgaaataat gtaaaaaagg agtatttatg gacatttcag
    15181 taattcgtca gaaaattgac gcaaatcgtg aaaaattagc ttctttcagg gggtctcttt
    15241 gacctcgaag ggctagagga agagattgcc atcttggaaa acaagatgac agaacctgat
    15301 ttttggaacg ataatattgc ggcccaaaaa acgtcgcaag aattgaatga attaaaaaac
    15361 acttacaata ccttccataa gatggaagag ttgcaggatg aagtcgaaat tttattggat
    15421 tttttggctg aagacgagtc agtgcatgat gaactggtag cgcaattagc cgaacttgat
    15481 aagataatga ccagctacga gatgactcta ctcttgtcag aaccttatga ccacaacaat
    15541 gccatcttgg aaatccatcc aggttctggt ggtactgagg cgcaggactg gggtgatatg
    15601 ttgcttcgta tgtatactcg ttatggtaat gctaaaggct ttaaagtgga agtgttggat
    15661 taccaagcag gtgatgaggc tggtattaag tcggtaactt tatcatttga agggcctaat
    15721 gcctatggtc tcctcaagtc agaaatgggt gttcaccgct tagtgcgaat ctcaccattt
    15781 gactctgcca aacgtcgcca tacctctttc acatctgtag aagtgatgcc agaattggat
    15841 gatactattg aagtggaaat ccgtgaagat gatatcaaga tggatacctt ccgttcaggt
    15901 ggtgccggtg gacaaaacgt caataaggtt tcaacaggtg tacgtttaac ccacattcca
    15961 actggaattg ttgtccaatc aacagtggat cgtacccagt atggaaatag agatcgtgcc
    16021 atgaagatgt tgcaggctaa gctctatcaa atggagcaag ataagaaggc tgcggaggta
    16081 gattctctca aaggtgagaa aaaggagatc acttggggaa gccaaatccg ttcttatgtc
    16141 ttcacgcctt atactatggt aaaagatcac cgaactagct ttgaggttgc tcaggtagat
    16201 aaggttatgg atggggacct agatggtttt atcgatgctt atctcaagtg gcgaattagc
    16261 taagatagaa aggaactcac atgtcaatta ttgaaatgag agatgtcgtt aaaaaatacg
    16321 acaacggaac gactgctcta cgcggtgttt cggtcagcgt tcaaccgggg gaatttgctt
    16381 acatcgtagg accttcagga gcagggaagt caacttttat tcgttctctg tatcgtgaag
    16441 taaaaatcga taaaggaagt ctatcagttg ctggttttaa tctggttaag atcaaaaaga
    16501 aagatgtccc gcttctacgt cgtagtgttg gggttgtctt ccaagattat aaattgttac
    16561 caaagaaaac tgtctatgaa aatattgctt acgctatgga agtaatcggg gaaaatcgcc
    16621 gtaatatcaa aagacgagtg atggaagttt tggacttggt tggattgaag cataaggttc
    16681 gttctttccc aaatgaactc tcaggtgggg agcaacagcg aattgcgatt gcgcgtgcaa
    16741 ttgtaaataa tcccaaagta ttgatagctg atgagccaac aggaaatctg gatccggata
    16801 attcatggga aattatgaat ctcttggaac ggattaacct acaaggaaca actattttga
    16861 tggcgactca taatagccag attgtaaata ccttgcgcca ccgtgtcatt gccattgaaa
    16921 atggccgtgt cgttcgtgac gaatcaaaag gagagtatgg atacgatgat tagtagattt
    16981 tttcgccatt tatttgaagc cttaaaaagt ttgaaacgaa atggttggat gacagtagct
    17041 gctgtcagtt cagtcatgat tactttgacc ttggtggcaa tatttgcatc tgttattttc
    17101 aatacagcga aactagctac agatattgaa aataatgtcc gtgtagtagt ttatatccga
    17161 aaggatgtgg aagataatag tcagacaatt gaaaaagaag gtcaaactgt tacaaataat
    17221 gactaccaca aggtatatga ttctttgaag aacatgtcta cggttaaaag tgttaccttt
    17281 tcaagtaaag aagaacaata tgaaaaatta accgagataa tgggagataa ctggaaaatc
    17341 tttgaaggag atgccaatcc tctctatgat gcctatattg tagaggcaaa cactccaaat
    17401 gatgtaaaaa ctatagccga agatgctaaa aaaattgaag gtgtctctga ggttcaagat
    17461 ggcggtgcca atacagaaag actcttcaag ttagcttcat ttatccgtgt ttggggacta
    17521 gggattgctg ctttgttaat ttttatcgca gtttttttga tttcaaatac cattcgtatt
    17581 accattattt cccgcagtcg cgaaattcaa atcatgcgct tggtcggagc taaaaacagt
    17641 tatatccgtg gaccgttctt gttagaagga gcctttatcg gtttattggg agctatcgca
    17701 ccatctgttt tggtctttat tgtttatcaa attgtttacc aatctgtcaa caaatcgttg
    17761 gtagggcaaa atctatccat gattagtcca gatttattta gtccgttgat gattgcccta
    17821 ctatttgtga ttggggtttt cattggttca ttgggatcag gaatatccat gcgccgattc
    17881 ttgaagattt aggtaaaata gctgctttta tgaggagatt gcaaaatctc cttttttgct
    17941 acaagagttt ttgaaaagag atgcgcagaa gaaaagagct tccaaagaag tcccccagag
    18001 aagacttctt gatggctaat ttgaacttga aatttggcgc actagaaatt ttttagaaaa
    18061 aagtgtaatt tttttataaa agcctttaca aaaaaaatta aagtggtata attaaatcat
    18121 agaaagtgca aacgttttcg taaaacgttt gcctaaataa aaataaagga gatttgaatg
    18181 atgaaagata cattcaaaaa tgtcttgtct ttcgaatttt ggcaaaaatt cggtaaggct
    18241 ttgatggtag ttatcgcggt tatgccggct gctggtttga tgatttcaat cggtaagtct
    18301 atcgtgatga ttaacccaac ctttgcacca cttgtcatca caggtggaat tcttgagcaa
    18361 atcggttggg gggttatcgg taaccttcac attttgtttg ccctagccat tggaggaagc
    18421 tgggctaaag aacgtgctgg tggtgctttc gccgctggtc ttgccttcat cttgattaac
    18481 cgtatcactg gtacaatctt tggtgtatca ggcgatatgt tgaaaaatcc agatgctatg
    18541 gtaactactt tctttggtgg ttcaatcaaa gttgctgatt actttatcag tgttcttgaa
    18601 gctccagcct tgaacatggg ggtattcgta gggattatct caggttttgt aggggcaact
    18661 gcttacaaca aatactacaa cttccgtaaa cttcctgatg cactttcatt cttcaacggg
    18721 aaacgtttcg taccatttgt agttattctt cgttcagcaa tcgctgcaat tctacttgct
    18781 gctttctggc cagtagttca aacaggtatc aataatttcg gtatctggat tgccaactca
    18841 caagaaactg ctccaattct tgcaccattc ttgtatggta ctttggaacg tttgctcttg
    18901 ccatttggtc ttcaccacat gttgactatc ccaatgaact acacagctct tggtggtact
    18961 tatgacattt taactggtgc agctaaaggt actcaagtat tcggtcaaga cccactatgg
    19021 cttgcatggg taacagacct tgtaaacctt aaaggtactg atgctagtca atatcaacac
    19081 ttgttagata cagtacatcc agctcgtttc aaagttggac aaatgatcgg ttcattcggt
    19141 atcttgatgg gtgtgattgt tgctatctac cgtaatgttg atgctgacaa gaaacataaa
    19201 tacaaaggta tgatgattgc aacagctctt gcaacattct tgacaggggt tactgaacca
    19261 atcgaataca tgttcatgtt catcgcaaca cctatgtatc ttgtttactc acttgttcaa
    19321 ggtgctgcct tcgctatggc tgacgtcgta aacctacgta tgcactcatt cggttcaatc
    19381 gagttcttga ctcgtacacc tattgcaatc agtgctggta ttggtatgga tatcgttaac
    19441 ttcgtttggg taactgttct ctttgctgta atcatgtact ttatcgcaaa cttcatgatt
    19501 caaaaattca actacgcaac tccagggcgc aacggaaact acgaaactgc tgaaggttca
    19561 gaagaaacca gcagcgaagt gaaagttgca gcaggctctc aagctgtaaa cattatcaac
    19621 cttcttggtg gacgtgtaaa catcgttgat gttgatgcat gtatgactcg tcttcgtgta
    19681 actgttaaag atgcagataa agtaggaaat gcagagcaat ggaaagcaga aggagctatg
    19741 ggtcttgtga tgaaaggaca aggggttcaa gctatctacg gtccaaaagc tgacattttg
    19801 aaatctgata tccaagatat ccttgattca ggtgaaatca ttcctgaaac tcttccaagc
    19861 caaatgactg aagcacaaca aaacactgtt cacttcaaag atcttactga ggaagtttac
    19921 tcagtagcag acggtcaagt tgttgctttg gaacaagtaa aggatccagt atttgctcaa
    19981 aaaatgatgg gtgatggatt tgcagtagaa cctgcaaatg gaaacattgt atctccagtt
    20041 tcaggtactg tgtcaagcat cttcccaaca aaacatgctt ttggtattgt gacggaagca
    20101 ggtcttgaag tattggttca cattggtttg gacacagtaa gtcttgaagg taaaccattt
    20161 acagttcatg ttgctgaagg acaaaaagtt gcagcaggag atctccttgt cacagctgac
    20221 ttggatgcta tccgtgcagc aggacgtgaa acttcaacag tagttgtctt cacaaatggt
    20281 gatgcaatta aatcagttaa gttagaaaaa acaggttctc ttgcagctaa aacagcagtt
    20341 gctaaagtag aattgtaata tacttgaggt tggaagctgt attccaacct cttattttgg
    20401 gagaaaagaa tgaaattttt aacactcaat actcacagtt ggatggagaa agaagcagag
    20461 gaaaaattcc agattttgct tgaagatatt cttgaaaagg actatgattt gatttgtttt
    20521 caagaaatca atcaggagat gacctcgtca gaggtggagg ttaatgacct ttatcaagct
    20581 ttgccagcag ctgagcctat tcaccaagac cattatgtta gactcttggt tgaaaagttg
    20641 tctgagcaag ggaaaaatta ctactggacc tgggcctata accatatcgg ctataaccgc
    20701 taccacgaag gtgtggctat cttgtctaaa acacctattg aagccagaga aattttggtt
    20761 tcagatgtgg atgatccaac agactatcat actcgccgtg ttgccctagc tgaaactgta
    20821 gtcgatggca aggagctagc agttgccagt gttcatctct cttggtggga taaaggtttc
    20881 caagaagaat gggcacgatt tgaggctgtc ttgaaaaaat tgaacaagcc acttttacta
    20941 gctggagatt tcaacaatcc ggctggacag gaaggttacc aagctatttt agctagtcca
    21001 ttaggcttac aagacgcatt tgaagttgct caagagaaaa gtggtagcta tactgttccg
    21061 cctgaaattg atggctggaa agggaacact gaaccccttc gaatcgatta tgtctttact
    21121 accaaagagt tagcggtgga aaatttacat gtcgtatttg atggtaacaa gagtccacaa
    21181 gtgagtgatc actatggctt gaatgctatg ttaaactgga aataataact gaaaagaggt
    21241 tggaactata aaattccagc cttttcttac tagagaagct actggaaata gcctaaataa
    21301 gtgagactac tgtaatggaa taaaatatgg tataattgat aagatagata gaatcgagga
    21361 tgttatgtca tttacgaaat ttcaatttaa aaactatatt agagaagcct tggaggagtt
    21421 aaaatttaca actccaacag aggtgcaaga caagttgatt cctattgttt tggcaggtcg
    21481 tgacctagta ggagaatcaa aaacaggttc aggtaagact catactttct tgttaccgat
    21541 tttccagcaa ttagatgaag ctagcgatag tgtacaagca gtgattactg caccgagtcg
    21601 tgagttggct actcaaattt accaagtagc gcgtcagatt tcagctcact cagatgtcga
    21661 agttcgtgtg gttaattatg tgggtggtac ggataaggct cgccagattg agaaattggc
    21721 aagcaatcag cctcatattg ttattggaac accaggccgt atctacgact tggttaaatc
    21781 tggtgattta gctattcata aagccaagac atttgttgtt gatgaagcag atatgacctt
    21841 ggatatggga ttcttggaaa ctgttgataa gattgctggc agtcttccaa aagacttgca
    21901 attcatggtc ttctcagcga ctatcccaca aaaactgcaa ccattcttga aaaaatactt
    21961 atccaatcct gttatggaga aaattaagac caaaacggtt atttctgaca ccattgataa
    22021 ttggttgatt tcgaccaagg gacatgataa gaatgctcaa atttaccagt tgactcagtt
    22081 gatgcagccg tatttggcaa tgatttttgt taacactaaa acgcgtgctg atgaattgca
    22141 ttcatatctg actgctcaag gcttgaaggt tgcaaaaatc catggagata ttgcccctcg
    22201 tgaacgcaag cgaatcatga atcaggtgca aaatctggat tttgagtata ttgtcgcaac
    22261 agatttggca gcgcgtggga ttgacattga aggtgtcagc catgtcatca atgatgccat
    22321 tccgcaagac ttatcttttt ttgttcatcg tgttggtcgt actggacgaa atggcctatc
    22381 aggtacagct attacccttt atcagccaag tgatgactcg gatatccgtg agttggagaa
    22441 attgggaatc aagtttagtc ctaagatggt caaagacggg gaatttcaag atacctatga
    22501 ccgtgatcgt cgtgccaacc gtgagaaaaa acaagataaa cttgatatcg aaatgattgg
    22561 tttggttaaa aagaaaaaga aaaaagtcaa accgggttat aagaagaaaa ttcaatgggc
    22621 ggttgatgaa aagcgccgta aaaccaagcg tgctgaaaat cgcgctcgcg gtcgtgcaga
    22681 tcgtaaagct aaacgccaaa cattttaata gaaattgttg gagtactgag ctccaacttt
    22741 tttatttatg agaacgaact atctaaaccg aaacactaca ttaaagactg caaattgcga
    22801 ttaaaaatgg tataatgata aagttatata gtcccgataa gatggtaggt atttattacg
    22861 aagagttttc ctatcagtac tttgtaactc tataacaata ttttttaagg ggggacattt
    22921 ttatgtcaga acgtaaatta ttcacgtctg aatctgtatc tgaggggcat ccggataaga
    22981 ttgcagacca aatttcagat gcgattttgg atgctatttt agcaaaggat ccagaggcgc
    23041 atgttgctgc tgaaacagct gtatatactg gttctgtcca cgtttttggt gaaatttcta
    23101 caaatgccta tgtggatatt aaccgtgtgg ttcgtgatac cattgcagag attggttata
    23161 ccaatacaga atatggattt tctgctgaga cggtgggagt acacccatct ttggtggaac
    23221 aatctcctga catcgctcaa ggtgttaacg aagccttgga ggttcgtgga aatgctgatc
    23281 aagatccact ggacttgatt ggagcaggtg accaagggct catgtttgga tttgcagtag
    23341 atgaaacaga agagcttatg ccattgccaa ttgcactcag tcataaattg gttcgtcgtc
    23401 tggcagaact tcgtaagtct ggagaaatta gctatctccg tccagatgca aaatcacaag
    23461 ttacagttga gtacgatgaa aatgaccgtc cggtacgtgt agatacagtc gttatttcta
    23521 ctcagcatga tccagaggcc actaatgaac aaatccatca agatgtgatt gacaaggtca
    23581 tcaaagaagt tattccatct tcttatcttg atgataagac aaaattcttt atcaatccga
    23641 caggtcgttt tgtaatcggt ggtcctcaag gggactcagg tttgactggt cgtaagatta
    23701 ttgtagatac ttatggtggc tactctcgtc atggtggtgg tgccttctct ggtaaagatg
    23761 cgactaaggt ggatcgttca gcctcttatg cggctcgcta tattgccaag aatatcgttg
    23821 cagcaggcct tgctaagaag gcagaagtgc agttggccta tgctatcggt gttgcgcaac
    23881 ctgtttctgt tcgtatcgat actttcggta caggaacagt agctgaaagt caacttgaaa
    23941 aagcggctcg tcaaatcttt gaccttcgcc ctgcagggat tatccaaatg ctggacctca
    24001 agcgtccaat ttaccgtcaa acatcggctt acggtcacat gggacgtaca gatattgatc
    24061 ttccatggga acgtttggat aaggtagatg ctttgaaaga agcagtaaaa taagatttta
    24121 agaggggaac gtcctctctt ttttatagtt tttaactata ctgggatact gttctgaaaa
    24181 tccattttgc gaaagtagag atttacatgt atagtagatt gaaactagaa tagtacacct
    24241 caacttctaa aacattgtta gcaatcaatt tgactgtcct gatcgatttc tcctgttctt
    24301 gtttcatttt actatatttc tttaaaaatg ataaaggtta agatttctcc tcgtaataga
    24361 taatcttgag gatatttcaa tccaaagttt tattcgttat cacttgacta ttgcaaggtt
    24421 ttctagagca acagagtcat ggaatggact catggttgag atttctcctt gttgcttgga
    24481 cttcattcaa aagtctgtta cccaagcctt gttcaaactt ctaatacact agctgtttcc
    24541 atagcatgac ttctgtacta gactttcttt tccaaataaa tagatagaac cacagaatct
    24601 agtaaaccta gaattaaaat tatggtataa tattagcaat aaaagaaatc tggaggatta
    24661 gaatcatggt atcaacgaaa acacaaattg ctggttttga gtttgacaat tgcttgatga
    24721 atgcagcagg tgtggcttgt atgacgatag aggagttaga agaggtcaaa aactcagcgg
    24781 caggaacctt tgttactaag acagcgacct tggacttccg tcaggggaat cctgagccac
    24841 gctaccaaga tgttccactt ggttccatca actctatggg cttgccaaat aatggcttag
    24901 actattattt ggattatctt ttagatttgc aggaaaaaga gtcgaaccga actttcttct
    24961 tatctctggt cggcatgtct ccagaggaaa cccatactat tttgaaaaaa gtccaagaga
    25021 gtgattttcg tggtctgact gagctaaatc tttcctgtcc aaatgttcca ggtaaacctc
    25081 agattgccta tgattttgag acaacagacc ggattttggc agaagtgttt gcttacttca
    25141 ccaaacctct tggaattaaa ttgccacctt attttgatat tgttcacttt gatcaagcgg
    25201 cagctatttt caacaaatat ccgctcaagt ttgtcaactg cgttaactct atcggaaacg
    25261 gcctctatat agaagacgaa tctgtcgtta ttcggcctaa gaatggtttt ggtggaattg
    25321 gtggagaata catcaaaccg actgctttag ccaatgttca cgccttttat caacgtttaa
    25381 atcctcaaat ccaaattatc ggaacaggtg gcgttctgac tggtcgagat gcctttgaac
    25441 acatcctctg tggagcaagt atggtgcagg tgggaacgac ccttcacaaa gaaggcgtca
    25501 gtgcttttga ccgcattacc aatgaactga aagcaatcat ggtggaaaaa ggctacgaga
    25561 gcttagaaga tttccgtggg aaattgcgct atattgacta aattaaatcg aaaaatctga
    25621 agaaaggaga gacgatgcta gccattgaag aaagtcagaa gttgacttta tcaaatttac
    25681 cgagcctgag cctatttaca gggacagatc agggtcagtt tgaagtgatg aagagtcaag
    25741 tgttgaaaca gattgggtat gattctgctg acctcaactt tgcctacttt gatatgaaag
    25801 aagtagttta caaggatgtg gaactggagt tggtcagcct tcctttcttt gcggatgaga
    25861 aaatcgtgat attagattat tttatggata tcacgactgc taagaaacgc tttttgacag
    25921 atgatgagct taagtcattt gaggaatacc ttgacaatcc ttctccaaca accaagttga
    25981 taatctttgc agaaggaaag ctggatagca aaagacggtt agtcaaatta cttaagcgtg
    26041 atgccaaggc cttcgatgca gtagaagtaa aagaacaaga attgcgccag tacttccaaa
    26101 agtggagtca gaaacaaggt ctgcagttta ccaatcattc ttttgaaaat ctcctcatca
    26161 agtcggggtt tcaatttagc gaaatccaga aaaatcttct ctttttacag tcctataagg
    26221 cggattctgt tatcgaggaa gaggatattg ttaacgcaat tcccaagacc ttgcaggaca
    26281 atatttttga tttaactcag tttattctga ctaaaaagat ggatcaggcg cgcgatttgg
    26341 tgagagactt gaccttgcaa ggggaagatg aaatcaaact gattgcagtc atgctgggac
    26401 aatttcggac ttttactcag gtgaagattt tggcggagtc tggccaaaca gaatcgcaga
    26461 ttgcaagtag tttaggtagt tatctgggac gtaacccaaa tccttatcaa atcaagtttg
    26521 cattaagaga ttcgagagga ctttctttga gctttctgaa gcaagctatt tcctatttga
    26581 ttgagacaga ctatcagatt aagacaggtc tttatgaaaa aggtttcctt tttgaaaagg
    26641 cactcttaca gattgctagt caggtcaatt gacatttgtt gaaactacaa cccgcgtcag
    26701 gattatcttg tcgtgggttt cttgctgatt tgcttatttt attagaaagt atgtcagtga
    26761 tttccttatc tataagcaaa aaacttgaaa aaagtgaatg tttgcgttat cattttcata
    26821 tagaaagaaa aagaggtatt acagatggct attatcttac cagaacttcc atatgcatac
    26881 gacgctttgg aaccatacat cgatgcggaa acaatgcatt tgcaccatga caaacaccat
    26941 caaacttatg tcaacaatgc caatgcagct ttagaaaaac accctgaaat cggtgaagac
    27001 cttgaagcct tgcttgctga tgtagaatct atcccagctg atatccgtca agcacttatc
    27061 aacaatggtg gcggacactt gaaccacgct cttttctggg aattgatgac tcccgagaaa
    27121 acagctcctt cagcagaact ggcagcagca atcgatgcaa catttggttc atttgaagaa
    27181 ttccaagcag ccttcactgc agcagcaaca actcgttttg gttcaggttg ggcatggttg
    27241 gttgtcaaca aagaagggaa acttgaagtg acttcaacag caaaccaaaa cacaccaatc
    27301 tcagaaggta aaaaaccaat cttgggcttg gacgtttggg aacatgctta ctacgtgaaa
    27361 taccgcaacg tgcgtcctga ctatatcaaa gctttctttt cagtaatcaa ctggaataaa
    27421 gtagatgaat tgtacgcagc tgctaaataa tgatagttgg agggaagaat tgttcttctc
    27481 tttttaggtt ataagattct ggtctgacaa aatcgtcaga cttttttcat ttttatgaga
    27541 aacgtgctaa ctgctagaaa ttatggtaga ataaagtatt aagtaatcgt ggaaaaagga
    27601 tatctatgcg aaaagaaatt gcacctgaat tatacaacta taacaagttt cctggtccgg
    27661 agttccattt acacggggac aaggtcgaaa cggaagggat agctttttcc ttggttgaaa
    27721 atatcaagga tgcctttgat gtgacgactt ttaatcagcg tttttcagaa gtcttaacca
    27781 agtttgatta tatcgtgggg gactggagca acgaacagct tcgcctacga ggtttttaca
    27841 aggatgaccg aacagaagaa aaacttgaaa aaatcagtcg tttacaagac taccttttag
    27901 agtattgtag ttatggttgt gcctattttg tcttagaaaa tgaagcccct aagcgagcat
    27961 catttgacaa gaaaatgcgt aagacggaag aagaaacacc ttctagaaaa ggaaagaaac
    28021 cgactcaaac taaacgaaag tcgaatgcag ataagaaaaa tagacgtcgt cagaaagacc
    28081 agcattctca gaaagaggac aagggacaac gtcattttgt cattcgtcag aagtgagtag
    28141 agaataagga gaagaaatga aaccctcaat tcatagtttg gcacatcaaa ccatgcagga
    28201 atgggtattg gagcagggag aaaagaaatt ccgtgcagat caaatctggg aatggctcta
    28261 ccgtaaacgt gtgcagtcat ttgaagaaat gaccaacctt tccaaggatt tgattgctaa
    28321 gctcaatgac cagtttgtgg tcaatccctt gaaacaacgt attgtgcaag agtctgctga
    28381 tggtacagtc aaatatctct ttgaattgcc tgacggtatg ttaattgaga ctgtactcat
    28441 gcgtcaacac tatggtttat ctgtctgtgt gaccactcag gtcggctgta atatcggttg
    28501 taccttctgt gcctctggtt tgattaagaa gcaacgtgac ctcaataacg gtgaaatcgt
    28561 agcgcaaatc atgctggttc agaaatactt tgctgagcgt ggtcaggatg aacgcgtcag
    28621 ccatatcgtt gtcatgggaa tcggtgagcc ctttgataat tacaacaatg tcttgaattt
    28681 ctttcgtact atcaatgatg ataaaggaat ggctatcggt gctcgtcaca tcatgatttc
    28741 aacctcaggt ttggctcata aaattcgtga ctttgctgat gaaggggttc aggtcaatct
    28801 tgccgtgtct cttcacgcac ccaacaatga acttcgttca agtatcatga aaattaaccg
    28861 tgcctttccg attgaaaaac tctttgctgc tattgaatac tatattgaga caacaaaccg
    28921 tcgtgtaacc tttgaatata tcatgcttaa tgaagtcaac gacggtgtag aacaagcctt
    28981 ggaattggct gaattgctca agaacatcaa gaaattgtct tatgtaaact tgattcctta
    29041 taacccagtt agtgagcatg accaatatag ccgtagtccc aaagagcgcg tgttggcttt
    29101 ctatgatacg cttaagaaaa aaggggtcaa ctgtgtggtt cgtcaagagc atggtacaga
    29161 tattgacgca gcttgtggac aattgcgctc taacacaatg aaacgtgacc gccagaaggc
    29221 agtcgcagcg gtaaatcctt aatgatgaag aagacttata atcatatttt ggtctgggga
    29281 gtcattttct atagcatttg cattgtctat ttttgcttta ctcctcaaga acaatctacc
    29341 gtgggagtgg gaactccagg tattcagcat cttggacgcc tggtttttct tttgactcct
    29401 ttcaattctc tctggaaact gggcgaagtg agtgacattg gacaattatg ttggattttt
    29461 ttacaaaatg tcctcaatgt cttcttattt tttcctctga ttttccaact cctttatcta
    29521 tttccaaatt tgcggaaaac aaaaaaggtc cttcttttta gttttcttgt gagtcttgga
    29581 atcgagtgta cgcaattaat cttggacttt ttctttgatt tcaatcgcgt ctttgagatt
    29641 gatgatttgt ggaccaatac tttgggtggc tatctggctt ggctccttta taaacgatta
    29701 cataaaaaca agataaggaa ttaaaatgag tattttagaa gttaaaaatc tgagtcacgg
    29761 ttttggtgac cgtgcaattt ttgaagatgt gtccttccgt ctcctcaagg gagaacatat
    29821 cggcctggtc ggtgccaatg gtgaaggaaa atcaaccttt atgagtatcg tgactggtaa
    29881 aatgctgcca gatgaaggaa aggttgagtg gtccaaatat gtgacggctg gttacttgga
    29941 tcagcactct gtccttgctg aaagacagtc ggtgcgtgat gttctccgta cggcttttga
    30001 tgagcttttc aaagctgaag ctcgtatcaa tgacctctat atgaaaatgg ctgaagacgg
    30061 cgcggatgtt gatgctctca tggaagaagt aggagaactt caagaccgtc tggagagtcg
    30121 tgatttctat accttggatg ctaagattga cgaagtagcg cgtgctcttg gtgttatgga
    30181 ctttggcatg gatacggatg taacttcttt gtcaggtggg caaagaacca aggtgctttt
    30241 ggcaaaactt ctccttgaaa agcctgatat tttgctgttg gacgagccga ccaactactt
    30301 ggatgctgag catattgatt ggctcaagcg ctatctccaa aactatgaga atgcctttgt
    30361 tctcatttcg cacgatattc cattcctcaa tgacgttatc aatattgtct atcatgtgga
    30421 aaatcaacag ctgacgcgtt actctggtga ctactaccag ttccaagaag tttatgctat
    30481 gaagaaatct cagctagagg cagcctacga acgccagcag aaagagattg cagacctcaa
    30541 ggactttgtg gctcgtaata aagcccgtgt tgcaactcgt aatatggcta tgtctcgtca
    30601 aaagaaattg gataagatgg atattatcga actccaaagt gagaaaccaa aaccatcctt
    30661 tgatttcaaa ccagctcgta caccagggcg ctttatcttc caagccaaga acttgcaaat
    30721 tggttacgac cgtcctctta ctaagccttt aaatcttacc ttcgaacgca atcaaaaggt
    30781 tgcgattatt ggtgctaatg gtattggaaa aacaactctc ttgaagagtc tcttgggcat
    30841 tatctcgcca atcgctgggg aagtggagcg tggagattat ttagaacttg gttattttga
    30901 gcaggaagta gaaggcggta atcgccaaac tcctcttgaa gctgtctgga atgcctttcc
    30961 tgcccttaat caagcagaag tccgtgcagc ccttgcccgt tgtggtttga caaccaaaca
    31021 tattgaaagc cagattcaag tattatcagg gggagagcaa gccaaggttc gtttctgtct
    31081 cttgatgaat cgtgaaaaca acgttttagt gctggacgag ccgaccaacc atttggatgt
    31141 ggatgcaaag gatgagctca aacgcgctct caaagaatat aggggatcta tccttatggt
    31201 ctgccacgag ccagactttt atgaaggctg gatagaccaa atatgggatt ttaataattt
    31261 aacttaagaa tgagagtaaa agaaatacag taccgaatgt ggatactgta tttttttggt
    31321 ttttaagatt taaaatcgta gtctttcacc acttcgatgc tgtcgattgt gatagcagta
    31381 gttggcttgt ctttttcatc tttttcggcc ttagcaatct tatccacaac atccataccg
    31441 tcaatcactt gaccaaagac tgggtgtttg ccatctagac tagggtttcc accttctttg
    31501 taggcttcga taattttctg tggatacttg cttgtaggga gtttagaaga ggtatctgta
    31561 gagttttggt tgatgaagaa ctggctgcca ttggtgtttg gttgaccagt attagccata
    31621 gcaagagcac cgcggatgtt atacaaataa ggagtaatct cgttcttgaa accagttcct
    31681 ttgtctttag tcttatcctt gtcatgccag atggactgac cacctgtacc gtcccctttt
    31741 ggatctccag tttggaccat aaagccatcg atgacacggt ggaaggtaat accgttatag
    31801 tagccttctt tggcgtgagt gaggaaattt tcaaccgcta gaggagcgag tttagggaag
    31861 agtttaatgc gaatatcacc ttggcttgtg tggagaatca cttcggcttc atcttcagca
    31921 acttccttag atagttgtgg gaaattggcg ttttcgtttg ttaaagcatc gtttaactcc
    31981 ttggcagatt gggcagctac tttggaactt tcttcagcag caagactgga atcaacataa
    32041 tcatcaccac gcagactgcg ttggacgctg ctacacccag ctagggctac agtagacagt
    32101 aaaagaaggg ttgctagttt tttcattctg atcctctcaa aaattcattt ataccattgt
    32161 accctaaaag gaagtggatt tcaaatatta gtagtttaca gaactggctt agataatagt
    32221 tgggatttca tcatcatctt gaaaatcttc aacttcttcc ccagtaaatg gtttctgaaa
    32281 agaacttagt ataaaacggg caattggttc aacaattagg aaatttagag gaagagctgc
    32341 aataaagttt acgaaccagg cgcttagata ggtattgggt gtgatagcaa tgccattgta
    32401 aaaaagtcca tagaaggaca tgaaagtgac cagctaattc ttcttctgaa aaatgctcat
    32461 gaagggcttg atccaggtcg caagatttca ttttagaaag tccagtaact cccttcttct
    32521 tcaggatatt ctttttcatg gtattattta gatggtcaag tgagtcaaaa gaagtttcga
    32581 caagagcata ccctttttct accagagttt ttagatgttt aggggcatca ataccataag
    32641 tgtactcaaa gtattttgga aaccagatct taagaaagct cgtaaagcta gccagttctc
    32701 taaacgctaa gaactagcta caacacagca tttacaacac ttcatggttc acaccatggg
    32761 gtgtttttta atgattttaa gcaaaattca cacttaattg aaagttattt aaattagatg
    32821 aaaatttatt ttttgaaaaa gtgggaaaac attgattcta agcgaatttt gaatcatatt
    32881 cgaatgggag tttttaaaat catgtttcag tggtaaaagt accaaactgg attctccata
    32941 gtaaaatgat atctcctgct agtgaatcat ctactaataa gtccatattt cgcttgggaa
    33001 cgggcttggg acttagaagc caagtatcca actctcgttc aggcgatatg aagggtttga
    33061 cttggtgttc tttataaaat ttttctaaaa tagtattcac ggatagcatc tttcaaac
//
LOCUS       DAVHSO010000020        32935 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.020, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000020 DAVHSO010000000
VERSION     DAVHSO010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32935)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32935)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32935
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.020"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            163..951
                     /gene="codY"
                     /locus_tag="VVR18_000903"
     CDS             163..951
                     /gene="codY"
                     /locus_tag="VVR18_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HEU6032457.1"
                     /translation="MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNAC
                     IINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIF
                     PVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN
                     FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITR
                     SVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY"
     gene            951..1526
                     /locus_tag="VVR18_000904"
     CDS             951..1526
                     /locus_tag="VVR18_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEU6032458.1"
                     /translation="MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFER
                     GDYIFFTIDAHEENDFFHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMD
                     KRHYSAFSGTDLDIRLRERRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS
                     IWPENHQFALGHFKNTLGAKLVDENLNELSE"
     gene            1608..1693
                     /locus_tag="VVR18_000905"
     tRNA            1608..1693
                     /locus_tag="VVR18_000905"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1642..1644,aa:Leu,seq:aag)
     gene            1976..3106
                     /gene="ugpC"
                     /locus_tag="VVR18_000906"
     CDS             1976..3106
                     /gene="ugpC"
                     /locus_tag="VVR18_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HEU6032459.1"
                     /translation="MVELNLKNIYKKYPNSEHYSVEDFNLNIKDKEFIVFVGPSGCGK
                     STTLRMIAGLEDITEGTASIDGVVVNDVAPKDRDIAMVFQNYALYPHMTVYDNMAFGL
                     KLRKYSKEDINKRVQEAAEILGLKEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD
                     EPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATKNPAGT
                     GTIGRVEQIGTPQEVYKNPVNKFVAGFIGSPAMNFINVKLVGSEIVSDGFRLKVPEGA
                     LKVLREKGYEGKELIFGIRPEDVNAEPAFLETFPDCVVKATISVSELLGSESHLYCQV
                     GKDEFVAKVDARDYLQTGATVELGFDLNKAHFFDVETEKTIY"
     gene            complement(3253..3399)
                     /locus_tag="VVR18_000907"
     CDS             complement(3253..3399)
                     /locus_tag="VVR18_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032460.1"
                     /translation="MEIKEQTRKLAVSCSKYIFEVADKTDEISNHTYGKATLTWFEEI
                     FEEY"
     gene            3607..4365
                     /locus_tag="VVR18_000908"
     CDS             3607..4365
                     /locus_tag="VVR18_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001848902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEU6032461.1"
                     /translation="MSEAGHKFLAKLGKKRLRPGGKRATDWLIAEGGFSKEKRILEVA
                     CNRGTTAIELAQRFGCKITAVDMDAQALEVAKKSAGTAGVAHLISFERANAMKLPYQD
                     ASFDIVINEAMLTMQADQAKKKCVMEYLRVLKPGGLLLTHDVLLKEAKESIRQELSQA
                     IHVNVGPLTQDGWEQVMIESGYCDVKALTGEMTLMKLSGMIYDEGLLGTLKICVNACK
                     KENRKQFLTMYKMFAKNKQKLGFIAMASYKSSKR"
     gene            4452..4964
                     /locus_tag="VVR18_000909"
     CDS             4452..4964
                     /locus_tag="VVR18_000909"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HEU6032462.1"
                     /translation="MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYA
                     TDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLT
                     MHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
                     DYDYKVLMHY"
     gene            5146..6090
                     /locus_tag="VVR18_000910"
     CDS             5146..6090
                     /locus_tag="VVR18_000910"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HEU6032463.1"
                     /translation="MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLM
                     PQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDG
                     MIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
                     DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVG
                     VSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLC
                     WSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL"
     gene            6099..6776
                     /locus_tag="VVR18_000911"
     CDS             6099..6776
                     /locus_tag="VVR18_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain-containing protein"
                     /protein_id="HEU6032464.1"
                     /translation="MTYLDAFKSGTLVLPSALLLHFKELFPSSDDFLVWQFFYLQNTT
                     GLEEMSPSQIAERIGKEISDVNQSISNLTERGLLQYRTIELNGEIELLFDASLALERL
                     DDLFGAVRSSSDQLTPQNQLKDLVETFQQELGRLLTPFEIEDLTKTLKEDGTSADLIK
                     EALREAVLNGKPNWKYIQAILRNWRYEGIKSVAQIEAKRAEREASNPQLTQVSADFIN
                     AMDLWKD"
     gene            6874..7632
                     /locus_tag="VVR18_000912"
     CDS             6874..7632
                     /locus_tag="VVR18_000912"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000087908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HEU6032465.1"
                     /translation="MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAP
                     ALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDY
                     FHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQV
                     AASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPE
                     NVASYMACPDVDGALVGGASLEAESFLALLDFVK"
     gene            7670..9174
                     /gene="lytC"
                     /locus_tag="VVR18_000913"
                     /pseudo
     CDS             7670..9174
                     /gene="lytC"
                     /locus_tag="VVR18_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078138769.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase LytC"
     gene            9670..10188
                     /locus_tag="VVR18_000914"
     CDS             9670..10188
                     /locus_tag="VVR18_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="HEU6032466.1"
                     /translation="MVELKKEAVKDVTSLTKAAPVALAKTKEVLNQAVADLYVAHVAL
                     HQVHWYMHGRGFLVWHPKMDEYMEALDGQLDEISERLITLGGSPFSTLTEFLQNSEIE
                     EEAGEYRNVEESLERVLVIYRYLSELFQKGLDVTDEEGDDVTNGIFAGAKTETDKTIW
                     MLAAELGQAPGL"
     gene            10318..10824
                     /locus_tag="VVR18_000915"
     CDS             10318..10824
                     /locus_tag="VVR18_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="HEU6032467.1"
                     /translation="MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAIL
                     MGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGG
                     KQIFQAFEAYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTI
                     QYRKRKEV"
     gene            10824..10994
                     /locus_tag="VVR18_000916"
     CDS             10824..10994
                     /locus_tag="VVR18_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000442275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032468.1"
                     /translation="MERSLFGLFTAFLCFICFLAGAQAFRKKRYGLSILLWLNAFTNL
                     VNSIHAFYMTLF"
     gene            11026..12258
                     /gene="clpX"
                     /locus_tag="VVR18_000917"
     CDS             11026..12258
                     /gene="clpX"
                     /locus_tag="VVR18_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002874765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HEU6032469.1"
                     /translation="MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQE
                     IIREELVEEVLADLSEVPKPIELLHILNHYVIGQDRAKRALAVAVYNHYKRINFHDTR
                     EESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
                     ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGT
                     VASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAI
                     DENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALVKQYQ
                     TLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLV
                     RITKETVDGTDKPILETA"
     gene            12267..12854
                     /locus_tag="VVR18_000918"
     CDS             12267..12854
                     /locus_tag="VVR18_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002915299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HEU6032470.1"
                     /translation="MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINT
                     MLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGCMIEEYL
                     TTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESA
                     IKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL"
     gene            12865..13245
                     /locus_tag="VVR18_000919"
     CDS             12865..13245
                     /locus_tag="VVR18_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HEU6032471.1"
                     /translation="MAKTIHTDKAPKAIGPYVQGKIVGNLLFASGQVPLSPETGEIVG
                     ENIQEQTEQVLKNIGAILAEAGTDFDHVVKTTCFLSDMNDFVPFNEVYQTAFKEEFPA
                     RSAVEVARLPRDVKVEIEVIAEIG"
     gene            13297..14187
                     /gene="rapZ"
                     /locus_tag="VVR18_000920"
     CDS             13297..14187
                     /gene="rapZ"
                     /locus_tag="VVR18_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HEU6032472.1"
                     /translation="MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPK
                     FLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVA
                     RYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFS
                     DQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVM
                     NHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKCLAQDLSKN
                     WSVNEGHRDKDRRKETVNRS"
     gene            14184..15161
                     /locus_tag="VVR18_000921"
     CDS             14184..15161
                     /locus_tag="VVR18_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HEU6032473.1"
                     /translation="MRKPKITVIGGGTGIPVILKSLREKDVEIAAIVTVADDGGSSGE
                     LRKNMQQLTPPGDLRNVLVAMSDMPKFYEKVFQYRFSEDAGAFAGHPLGNLIIAGLSE
                     MQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVVGESHIVDHRGIIDNV
                     YVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEI
                     AYVCNIMTQRGETEHFTDSDHVEVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYL
                     VQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMRIIQVKK"
     gene            15158..16069
                     /gene="whiA"
                     /locus_tag="VVR18_000922"
     CDS             15158..16069
                     /gene="whiA"
                     /locus_tag="VVR18_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HEU6032474.1"
                     /translation="MSFTVAVKEEILGQHHLSWHELSAIIKMSGSIGLSTSGLTLSVV
                     TENAKLARHLYESFLHFYEIKSEIRHHQRSNLRKNRVYTVFTDEKVQDLLSDLHLADS
                     FFSLETGIDEAILSDEEAGRAYLCGAFLANGSIRDPESGKYQLEISSVYLDHAQGIAS
                     LLQQFLLDAKVLERKKGAVTYLQRAEDIMDFLIVIGAMQARDDFERVKILRETRNDLN
                     RANNAETANIARTVSASMKTINNISKIKDIMGLENLPVDLQEVAQLRIQHPDYSIQQL
                     ADSLSTPLTKSGVNHRLRKINKIADEL"
     gene            complement(16103..17071)
                     /locus_tag="VVR18_000923"
     CDS             complement(16103..17071)
                     /locus_tag="VVR18_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000081018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEU6032475.1"
                     /translation="MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPA
                     ILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTS
                     KGSHLTKTVIIAMGGGAFKPRPLELEGVEGYENIHYHVSNIQQYAGKKVTILGGGDSA
                     VDWALAFEKIAPTTLVHRRDNFRALEHSVQALQESSVTIKTPFAPSQLLGNGKTLAKL
                     EITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLDLNRHKIIVNSKQESSQAGIYA
                     IGDCCYYDGKIDLIATGLGEAPTAVNNAIKYIDPEQKVQPKHSTSL"
     gene            17207..18064
                     /locus_tag="VVR18_000924"
     CDS             17207..18064
                     /locus_tag="VVR18_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001867651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HEU6032476.1"
                     /translation="MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIA
                     GTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLER
                     LGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYISTGIPLD
                     AKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIG
                     LSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERL
                     LGGWKHEKK"
     gene            18051..18830
                     /locus_tag="VVR18_000925"
     CDS             18051..18830
                     /locus_tag="VVR18_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbbR-like domain-containing protein"
                     /protein_id="HEU6032477.1"
                     /translation="MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNT
                     VTNVPIDIRYNSDKYFISGFASEVSVVLTGANRLSLASEMQESTRKFKVTADLTDAGV
                     GTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSRVQIENV
                     MVSDKEVSITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITP
                     FDTIMKVTTKPVAPSSSTSNSSTSSSSETSSSTKATSSKTN"
     gene            18854..20206
                     /locus_tag="VVR18_000926"
     CDS             18854..20206
                     /locus_tag="VVR18_000926"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HEU6032478.1"
                     /translation="MGKYFGTDGVRGEANLELTPELAFKLGRFGGYVLSQHETEAPKV
                     FVGRDTRISGEMLESALVAGLLSVGIHVYKLGVLATPAVAYLVETEGASAGVMISASH
                     NPALDNGIKFFGGDGFKLDDEKEAEIEALLDAEEDTLPRPSAEGLGILVDYPEGLRKY
                     EGYLVSTGTPLDGMKVALDTANGAASTSARQIFADLGAQLTVIGETPDGLNINLNVGS
                     THPEALQEVVKESGSAIGLAFDGDSDRLIAVDENGDIVDGDKIMYIIGKYLSEKGQLA
                     QNTIVTTVMSNLGFHKALNREGINKAVTAVGDRYVVEEMRKSGYNLGGEQSGHVILMD
                     YNTTGDGQLSAVQLTKIMKETGKSLSELAAEVTIYPQKLVNIRVENVMKEKAMEVPAI
                     KAIIEKMEEEMAGNGRILVRPSGTEPLLRVMAEAPTTEEVDYYVDTITDVVRAEIGID
                     "
     gene            20280..20654
                     /locus_tag="VVR18_000927"
     CDS             20280..20654
                     /locus_tag="VVR18_000927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1149 family protein"
                     /protein_id="HEU6032479.1"
                     /translation="MNLKREQEFVSQYHFDARNFEWENENGAPETKVDVNFQLLQHDQ
                     ENQVTSLIVILSFMIVFDKFVISGTISQVNHIDGRIVNEPSELNQEEVETLARPCLNM
                     LNRLTYEVTEIALDLPGINLEF"
     gene            20656..21504
                     /locus_tag="VVR18_000928"
     CDS             20656..21504
                     /locus_tag="VVR18_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEU6032480.1"
                     /translation="MKLAVFTDSSAYLSAETLQREDLFVLDIPVNIDGEEYVEGINLS
                     AEEFYQKMAQASELPKTSQPSIAKLDEILTSLKEQGYTHALGLFLSSGISGFYQNIQY
                     MVDDYEGLTIAFPDTLITSAPLGIMVESVFNWRDQGDDFASIQDKLAIQISRTSAFIM
                     VDDLDHLVKGGRLSNGAAILGNLLSIKPILYFNDQGMIEVYEKVRTEKKATKRLIEII
                     KETTASGQYRVIVIHGNAPEKAEELRQHLLDFGLGSDVSLATFGSVIGTHLGSGSIAL
                     GYIPVI"
     gene            21781..22548
                     /locus_tag="VVR18_000929"
     CDS             21781..22548
                     /locus_tag="VVR18_000929"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HEU6032481.1"
                     /translation="MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQ
                     GIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELK
                     EFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKT
                     AELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGL
                     TLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL"
     gene            22560..23744
                     /locus_tag="VVR18_000930"
     CDS             22560..23744
                     /locus_tag="VVR18_000930"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001138849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HEU6032482.1"
                     /translation="MPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIA
                     TSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVR
                     SLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMR
                     GFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIES
                     QAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKSWKTSR
                     QFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQ
                     SLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLRE
                     KK"
     gene            23741..25612
                     /locus_tag="VVR18_000931"
     CDS             23741..25612
                     /locus_tag="VVR18_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001279112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU6032483.1"
                     /translation="MSDFIVEKLTKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTT
                     LLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIRE
                     YELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGL
                     RRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDAL
                     STRIFELERAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQAR
                     ATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQDVSFAYENKPILQD
                     FNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTAGQVVIGETVRIAYFSQQIEGLD
                     ESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLL
                     KLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAF
                     EDGKIRPFFGHYTDYLDEKAFETDMANQVQKAEKEKVVKVREDKKRMTYQEKQEWASI
                     EGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYECYEYLSEFDS"
     gene            complement(25755..26939)
                     /gene="mntE"
                     /locus_tag="VVR18_000932"
     CDS             complement(25755..26939)
                     /gene="mntE"
                     /locus_tag="VVR18_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDF family manganese efflux transporter MntE"
                     /protein_id="HEU6032484.1"
                     /translation="MKQSISNLKLAERGAIISISTYLILSAAKLAAGHLLHSSSLVAD
                     GFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRD
                     TIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDA
                     VTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLED
                     YQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERF
                     GVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQM
                     DKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETK
                     KE"
     gene            27243..29939
                     /locus_tag="VVR18_000933"
     CDS             27243..29939
                     /locus_tag="VVR18_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HEU6032485.1"
                     /translation="MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHN
                     ELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAF
                     GVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLR
                     LIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVV
                     NTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKN
                     PLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIA
                     SDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIG
                     DPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGA
                     PDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLT
                     SEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGI
                     IDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAM
                     TGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNI
                     QKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGV
                     MNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALT
                     MAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGI
                     FHVTKLDLSQWGIVMAGSFSMIIIVEIVKFTQRKLGFDKNAI"
     gene            29952..30743
                     /gene="yghU"
                     /locus_tag="VVR18_000934"
     CDS             29952..30743
                     /gene="yghU"
                     /locus_tag="VVR18_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-dependent disulfide-bond
                     oxidoreductase"
                     /protein_id="HEU6032486.1"
                     /translation="MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQ
                     LYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPAL
                     LDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQVGAAPFLGGGFG
                     HFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLV
                     QGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK"
     gene            30859..31269
                     /locus_tag="VVR18_000935"
     CDS             30859..31269
                     /locus_tag="VVR18_000935"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEU6032487.1"
                     /translation="MEKKIVKDILFLSQVSQPASQEDLYLARDLQDTLLANRDTCVGL
                     AANMIGMQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRL
                     AYRDSKWQEQTITLTGFPAQICQHELDHLEGRII"
     gene            31281..32876
                     /locus_tag="VVR18_000936"
     CDS             31281..32876
                     /locus_tag="VVR18_000936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000822862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032488.1"
                     /translation="MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILF
                     GFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSM
                     FQAKNYANVVTVTEKDFTEFPKSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAAD
                     TYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYS
                     DSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVII
                     LDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTN
                     GYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEG
                     AVQEKSYKATFPILINLNDKPLYIMGLKDNAGLIKEYALVDAVEYQNVIVATTVEEML
                     SKYANKNDLEIDNATTESIKGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPY
                     LENGKTFEGQVGKDNYLKTFKVQ"
BASE COUNT         9720 a         6116 c         7582 g         9517 t
ORIGIN      
        1 aaaataggca acttgtcaat agaaaaggaa caatttaatt aaaaatattc tggtttttaa
       61 ttaaattgta agtcaatgca agtcaataag gaattttcag ataattattg aaaaagagac
      121 gtttttatgt tataatgata gcgattaaat tcgaggtgaa aaatggcaca tttattagaa
      181 aaaactagaa aaattacatc aattttgaaa cgctcagagg agcagttgca ggatgagctc
      241 ccttacaacg ctattacgcg tcagttagcg gatattattc attgcaatgc ctgcattatc
      301 aatagtaagg gacgtctgct tggctatttt atgcgttata aaacaaatac agatcgcgta
      361 gagcaattct tccaaactaa gattttccca gatgactacg ttcaaggggc taatatgatt
      421 tacgaaacag aagcaaactt gcctgttgag catgatatga gtattttccc tgttgagagt
      481 agagatgatt ttccagatgg cttgacgact attgcaccga ttcatgtatc ggggattcgc
      541 cttggttctt tgattatttg gcgtaatgat aaaaaattcg aagatgagga cttggttctt
      601 gttgagattg ccagtaccgt tgttgggatt cagcttctta acttccaacg tgaagaagat
      661 gagaaaaata ttcgtcgtcg tactgctgtc accatggcgg tcaataccct ttcttactcc
      721 gaactccgtg ctgtttcagc aattttaggg gaattaaatg gaaatgaagg gaagttgact
      781 gcgtcagtga ttgcagatcg tatcggaatc actcgctctg tgattgtcaa tgctcttcgt
      841 aaacttgagt ctgcggggat tattgaaagt cgctcacttg gaatgaaggg aacctatctt
      901 aaggtcttga tttcagatat ttttgaagaa gtgaagaaaa gagattacta atgacaaagg
      961 ctttaatttc gattgattat acagaagatt ttgttgctga tagtgggaag ctgacagcag
     1021 gtgctccagc tcaggcgatt tcggatgcca tcagcaaggt aactcgatta gcttttgaac
     1081 gaggagatta tatcttcttt actattgatg ctcatgaaga aaacgatttt ttccatccgg
     1141 aaagtaagtt atttcctcct cataatctga ttgggacgag tggacggaat ttatatggag
     1201 atttggggat cttttatcaa gagcatggtt cagacagtcg tgtcttttgg atggataaac
     1261 gccattactc agctttttca gggactgacc tagatattcg tttgagagag cgtagagtgt
     1321 ctaccgttat cttaacaggt gtcttgacgg atatctgtgt cctacataca gctatagatg
     1381 cctataatct aggatatgac atcgagattg ttaaaccagc tgttgcttct atctggcctg
     1441 aaaatcatca atttgcccta ggtcatttca aaaatacact cggagctaag ttagtagatg
     1501 aaaatctaaa tgaactttct gagtaacctg gttggtgaaa atgaaaaaat ttgaaaaaaa
     1561 gtgttgacaa gcatcccaaa agttgatata ctagtaaagt aatcgatgcg gggatggcgg
     1621 aattggcaga cgcgcaggac taaggatcct gtgaccgctt taggtcgtga gggttcaagt
     1681 ccctctctcc gcataggaaa agagttagct aaagctagct cttttgtatt tctctaaaaa
     1741 attagaatcc agtcaaatgt agtggagaat cagcgaaaat atgggaaaac tgatccttgt
     1801 ttctgctttt gtcatagaag aataataaag attatcttct tcaaattctc cgatattctc
     1861 taaagttttg tgcaagttgc acagaacttt tttatttttt tggtcatctt gccatagaaa
     1921 tataaagcgt tttcatctat aatataatta tcaaaagaca aaaggagttc acctcatggt
     1981 agaattgaat cttaaaaata tttacaaaaa atatccaaac agcgaacact attcagttga
     2041 agatttcaac ttgaacatca aagataaaga atttatcgtt ttcgtaggac cttcaggatg
     2101 tggtaaatca actacactcc gtatgattgc tggtcttgaa gacatcacag aaggtactgc
     2161 atctatcgat ggcgtggttg tcaacgacgt agctccaaaa gaccgtgata tcgccatggt
     2221 attccaaaac tacgctcttt acccacacat gactgtttat gacaacatgg ctttcggttt
     2281 gaaattgcgt aaatacagca aagaagacat taacaaacgt gttcaagaag cagctgaaat
     2341 acttggattg aaagaattct tggaacgtaa accagctgac ctttcaggtg gtcaacgtca
     2401 acgtgttgcc atggggcgtg cgattgtccg tgatgcgaaa gtattcttga tggacgaacc
     2461 tttgtcaaac ttggatgcca aacttcgtgt atcaatgcgt gctgaaatcg ctaaaattca
     2521 ccgtcgtatc ggagctacaa ctatctatgt aactcacgac caaacagaag cgatgacact
     2581 tgcagaccgt atcgttatta tgtcagctac taagaaccct gctggtacag gtactatcgg
     2641 acgtgtagaa caaatcggta ctcctcaaga agtttacaaa aatccagtta acaaatttgt
     2701 tgcaggattc atcggaagcc cagctatgaa tttcatcaac gtgaaattgg ttggtagcga
     2761 aattgtttct gacggtttcc gtttgaaagt gccagaagga gcattgaaag ttcttcgtga
     2821 aaaaggctac gaaggaaaag aattgatctt tggtatccgt ccagaagacg tgaatgcaga
     2881 acctgctttc cttgaaacat tcccagactg tgttgtaaaa gcgactatct ctgtatcaga
     2941 actgcttggt tcagaatctc acctttactg ccaagttggt aaagacgagt ttgttgcaaa
     3001 agttgatgct cgtgactact tgcaaacagg tgcaacagtt gagcttggat ttgacttgaa
     3061 caaagcacac ttcttcgatg tagaaactga aaaaacaatt tactaaaata aataaaattc
     3121 aaaacactac aagaaaagat atctctttat caattgtagt ggagagatat cagttaatct
     3181 agggagagaa acaaaatgct tctctccttt ttgctaggga agtcatatta tgcatctata
     3241 ttgtgatgct ctttaatact cttcgaaaat ctcttcaaac cacgtcaacg tcgccttgcc
     3301 gtacgtatga ttactgattt cgtcagtttt atctgcaacc tcaaagatgt actttgagca
     3361 gcttacggct agtttcctag tttgctcttt gatttccatt gagtattatt tgtgggtacc
     3421 atctacaagt gaagctatat gcgtaaacta cgtgagcaat tgaattcgaa ctagagaggt
     3481 aataataaat ttatgctata gttatggtga cttgtatgct tttgattcta gtttatcaaa
     3541 taatagatta gaattgtcag ataatatcat tttgtgttat aatgaagaaa aaacagaggt
     3601 gtgcaaatgt cagaagcagg tcataagttt ttagcaaaat tggggaaaaa acgcttacgt
     3661 ccaggtggaa agcgtgccac agattggtta attgcagaag gaggattttc aaaagaaaag
     3721 agaatactag aggttgcgtg taatagggga actacagcaa ttgagttggc acagcgtttt
     3781 ggttgcaaga taactgctgt tgatatggat gctcaagctt tagaagtggc taaaaaatct
     3841 gctggaacgg caggtgttgc tcatttaatc agttttgaaa gagcaaatgc aatgaaactt
     3901 ccttatcaag atgctagttt tgatattgtt ataaatgaag ctatgctgac tatgcaagcc
     3961 gatcaagcta agaaaaaatg tgtaatggaa tatctaaggg tattaaaacc tggaggtctt
     4021 ctcttgacac atgatgtact tcttaaggaa gctaaagagt ctatcagaca ggaattatca
     4081 caagcaattc atgtaaatgt aggtccttta actcaagatg gttgggaaca ggtgatgata
     4141 gaatcaggtt attgtgatgt gaaagcattg actggtgaaa tgacattaat gaaattatcg
     4201 ggtatgattt atgacgaagg tttgctagga actttgaaaa tttgtgtaaa tgcttgtaaa
     4261 aaggagaata gaaagcagtt tttaactatg tataaaatgt ttgctaagaa taaacagaaa
     4321 ttgggcttta ttgcgatggc tagttataaa tcgtcaaaac gttagataat tattgaagtt
     4381 aacttttcct tttttctttc ttaaaaaata tgctataata gagagtaaaa aactttgaaa
     4441 gaaagaaaaa gatgaattta aaagattaca ttgcaacaat tgaaaattat ccaaaggaag
     4501 gcattacctt ccgtgatatt agtcctttga tggctgatgg aaatgcttat agctacgctg
     4561 ttcgtgaaat cgttcagtat gctactgaca agaaagtcga catgatcgtg ggacctgaag
     4621 ctcgtggatt tatcgtgggt tgtccagttg cctttgagtt gggaattggt tttgcgcctg
     4681 ttcgtaagcc aggtaaattg ccacgcgaag ttatttctgc tgactatgaa aaagagtacg
     4741 gtgtcgatac cttgactatg cacgcggatg ccattaagcc aggtcaacgt gttcttattg
     4801 tagatgacct tttggcgaca ggtggaactg ttaaggcaac tatcgagatg attgaaaaac
     4861 ttggtggtgt tatggcaggt tgtgccttcc ttgttgaatt ggatgaattg aacggccgtg
     4921 aaaaaattgg tgactacgac tacaaagttc ttatgcatta ttaatgaaaa cagtccctag
     4981 ggctgttttc tctacactag gatataaaaa tagactataa ctagttagag aaaaactata
     5041 attgaaaact atatcttctt acagtataat aaaaggacta agtgtttgag atttgtcttc
     5101 aaacatatgc aattattcct gaaagagtac agttaggaga gggttatgcc gattcgaatt
     5161 gataaaaaat tgccagctgt tgagatttta cggacagaga atatctttgt catggatgat
     5221 caacgtgctg cccaccaaga tatccgtcct ttgaagattt taattttaaa tctcatgcca
     5281 cagaaaatgg tcacagagac ccagttgttg cgccacttgg ctaatacacc cctacaactg
     5341 gatattgatt ttctctatat ggagagccac cgttctaaaa caactcgttc agagcacatg
     5401 gagaccttct ataaaacttt tcctgaagtc aaggatgagt attttgatgg gatgatcatc
     5461 acgggtgctc cagttgagca tttaccattt gaggaagtgg actattggga ggaatttaga
     5521 cagatgcttg agtggtctaa gactcatgtc tattcgaccc ttcatatctg ttggggggct
     5581 caggctgggc tttatctgcg ctatggtgta gaaaaatacc agatggacag taagctatca
     5641 ggtatttatc ctcaggacac cctaaaagag ggtcaccttc tatttagagg ctttgatgat
     5701 agctatgtat cccctcattc acggcacacg gagatttcta aggaagaggt cttaaacaag
     5761 accaatctcg agattttatc agaaggacct caggttgggg tttctatttt ggccagtcgt
     5821 gatttacgag aaatttatag ttttggtcat ttggagtatg accgtgatac cttggcaaaa
     5881 gagtattttc gagatcgtga tgcaggtttc gacccacata ttccagaaaa ttactttaaa
     5941 gatgatgatg ttaatcaggt accttgtctt tgttggtctt catctgcagc cctctttttc
     6001 agtaattggg taaaccatgc ggtctatcag gagacgcctt ttgattggag aaagatagaa
     6061 gatgatgcat ctgcatatgg gtatttataa gaggaattat gacatattta gacgctttta
     6121 aatcaggtac cttggtttta ccgagtgccc tgctcttgca ttttaaggaa ctctttcctt
     6181 ctagcgacga ttttctggtt tggcaatttt tctatttgca aaatacgaca ggcttagaag
     6241 aaatgtcgcc aagccagatt gctgaaagga ttggcaagga aatttcggat gtcaaccagt
     6301 ccatttctaa tctgacggaa aggggactgc tccagtatcg tactatcgaa ttaaatggcg
     6361 aaattgaatt gctctttgat gctagtttgg ccttggaacg tttggatgac ctgtttggag
     6421 cagttcgttc aagttcagac cagctaacac ctcaaaacca gctcaaggat ttggtggaaa
     6481 ccttccagca ggagttggga cgattgttga cgccttttga gattgaggat ttgaccaaga
     6541 cactaaagga agatggaacc agtgctgact tgattaagga ggctcttcgt gaagctgttt
     6601 tgaatggaaa accaaactgg aagtacattc aggcgatttt gagaaactgg cgctatgaag
     6661 gaatcaagag tgtggctcaa attgaggcca agagagcaga aagagaagca agcaatcctc
     6721 agttgacaca ggtatctgca gatttcataa atgccatgga tctctggaag gattaatcca
     6781 tgcaagtagg cttgaaatcc gagtaagatt tgcaagctgt gtataattgt gatagaataa
     6841 atagaaaata aattgaaaaa agaggtatgt gaaatgtcac gtaaaccatt tatcgctggt
     6901 aactggaaaa tgaacaaaaa tccagaagaa gctaaagcat tcgttgaagc agttgcatca
     6961 aaacttcctt catcagatct tgttgaagca ggtatcgctg ctccagctct tgatttgaca
     7021 actgttcttg ctgttgcaaa aggctcaaac cttaaagttg ctgctcaaaa ctgctacttt
     7081 gaaaatgcag gtgctttcac tggtgaaact agcccacaag ttttgaaaga aatcggtact
     7141 gactacgttg ttatcggtca ctcagaacgc cgtgactact tccatgaaac tgatgaagat
     7201 atcaacaaaa aagcaaaagc aatctttgcg aacggtatgc ttccaatcat ctgttgtggt
     7261 gaatcacttg aaacttacga agctggtaaa gctgctgaat tcgtaggtgc tcaagtatct
     7321 gctgcattgg ctggattgac tgctgaacaa gttgctgcct cagttatcgc ttatgagcca
     7381 atctgggcta tcggtactgg taaatcagct tcacaagacg atgcacaaaa aatgtgtaaa
     7441 gttgttcgtg acgttgtagc tgctgacttt ggtcaagaag tcgcagacaa agttcgtgtt
     7501 caatacggtg gttctgttaa acctgaaaat gttgcttcat acatggcttg cccagacgtt
     7561 gacggtgccc ttgtaggtgg tgcgtcactt gaagctgaaa gcttcttggc tttgcttgac
     7621 tttgtaaaat aatcagtaag tagcaaaagc taggtggaac agcattcaga tgtctgttac
     7681 attttttata ggagagaaag attgaaaaca aaaattggat tagcaagtat ctgtttacta
     7741 ggcttggcaa ctagtcatgt cgctgcaaat gaaactgaag tagcaaaaac ttcgcaggat
     7801 acaacgacag cttcaagtag ttcagagcaa aatcagtctt ctaataaaac gcaaacgagc
     7861 gcagaagtac agactaatgc tgctgcccac tgggatgggg attattatgt aaaggatgat
     7921 ggttctaaag ctcaaagtga atggattttt gacaactact ataaggcttg gttttatatt
     7981 aattcagatg gtcgttactc gcagaatgaa tggcatggaa attactacct gaaatcaggt
     8041 ggatatatgg cccaaaacga gtggatctat gacagtaatt acaagagttg gttttatctc
     8101 aagtcagatg gggcttatgc tcatcaagaa tggcaattga ttggaaataa gtggtactac
     8161 ttcaagaagt ggggttacat ggctaaaagc caatggcaag gaagttattt cttgaatggt
     8221 caaggagcta tgatgcaaaa tgaatggctc tatgatccag cctattctgc ttatttttat
     8281 ctaaaatccg atggaactta tgctaaccaa gagtggcaaa aagtgggcgg caaatggtac
     8341 tatttcaaga agtggggcta tatggctcgg aatgagtggc aaggcaacta ctatttgact
     8401 ggaagtggtg ccatggcgac tgacgaagtg attatggatg gtactcgcta tatctttgcg
     8461 gcctctggtg agctcaaaga aaagaaagat ttgaatgtcg gctgggttca cagagatggt
     8521 aagcgctatt tctttaataa tagagaagaa caagtgggaa ccgaacatgc taagaaagtc
     8581 attgatatta gtgagcacaa tggtcgtatc aatgattgga aaaaggttat tgatgagaac
     8641 gaagtggatg gtgtcattgt tcgtctaggt tatagcggta aagaagacaa ggaattggcg
     8701 cataacatta aggagttaaa ccgtctggga attccttatg gtgtctatct ctatacctat
     8761 gctgaaaatg agaccgatgc tgagagtgac gctaaacaga ccattgaact tataaagaaa
     8821 tacaatatga acctgtctta ccctatctat tatgatgttg agaattggga atatgtaaat
     8881 aagagtaaga gagctccaag tgatacaggc acttgggtta aaatcatcaa caagtacatg
     8941 gacacgatga agcaggcggg ttatcaaaat gtgtatgtct atagctatcg tagtttatta
     9001 cagacgcgtt taaaacaccc agatatttta aaacatgtaa actgggtagc ggcctatacg
     9061 aatgctttag aatgggaaaa ccctcattat tcaggaaaaa aaggttggca atatacctct
     9121 tctgaataca tgaaaggaat ccaagggcgc gtagatgtca gcgtttggta ttaagcgatg
     9181 atttgaaaga gggatgtgat agtagcaccc tctttttctt tgttttatga tagttcatcc
     9241 tcgagtaaat tcaagatctt gctcggaaat gaagcttata tagtagattg aatatagaca
     9301 aataccttgt gattggtaaa acattttaga aattcattta cctttcctaa tcgacttggt
     9361 ttcatcttat ttcaatctat tatagtattg gggaatttct tcaaaccaca tcagcttggt
     9421 cagttctacc tgcgacctca aaacttgtgc tttggtcaag ctgggtttag tttcctagtt
     9481 tgctgatgga tttccattga ctataagcat ccaaccctct ttttgtcttc taaagaattc
     9541 ttaaattatc agtctattgc aacttttctc atataagttc tttgtcttgc tattggtttt
     9601 ccttagtagt atactaaggt agtaatcatt aagaagtggt tacaaaaaat aatgaatgag
     9661 gtaaagaaaa tggtagaatt gaaaaaagaa gcagtaaaag acgtaacatc attgacaaaa
     9721 gcagcgccag tagcattggc aaaaacaaag gaagtcttga accaagctgt tgctgatttg
     9781 tatgtagctc acgttgcttt gcaccaagtg cactggtata tgcatggtcg tggtttcctt
     9841 gtatggcatc caaaaatgga tgagtacatg gaagctcttg acggtcaatt ggatgaaatc
     9901 agcgaacgct tgattacact cggtggaagc ccattctcta cattgacaga gttccttcaa
     9961 aatagtgaaa tcgaagaaga agctggtgaa taccgtaatg ttgaagaaag cttggaacgt
    10021 gttcttgtta tctaccgtta cttgtcagaa cttttccaaa aaggtttgga tgtcactgat
    10081 gaagaaggtg acgatgtaac aaacggtatc tttgcaggcg ctaaaactga aacagataaa
    10141 acaatttgga tgcttgcagc cgaacttgga caagcacctg gtttgtaaga aataaggaaa
    10201 catagataaa tctgtaggaa atttcttaca gattttttct attttgtaag ctattccaaa
    10261 ccagtctttt tttgagtttt ttgataaaat agtactatca gtgaaaagga tggaagcatg
    10321 actaagaaaa tcgtagctat ttgggcccag gatgaagagg gtgtgattgg taaggaaaat
    10381 cgtctgcctt ggcatttgcc agcagaattg cagcacttta aagaaacaac tctgaatcat
    10441 gctatcttga tggggcgtgt gacctttgat gggatggggc gtcgcttgct tccaaaacgg
    10501 gaaaccttga ttttgacgcg taatccggaa gaaaagatag atggggttgc tacttttcag
    10561 gacgtccagt ctgttcttga ctggtatcag gctcaagaaa agaatctcta cattatcggt
    10621 gggaagcaaa tttttcaggc ttttgaagct taccttgatg aagtgattgt cactcacatt
    10681 catgctcggg tggaaggaga tacctatttc cctgaagagc ttgacttgtc tctttttgag
    10741 acagtttcaa gcaaatttta cgccaaagat gagaagaatc cttatgattt taccatccaa
    10801 taccgcaaga gaaaggaagt ttaatggaac ggagtttatt tggtctattc acggcttttc
    10861 tgtgtttcat ctgctttctg gcaggagcac aagcttttcg taaaaagcgt tacgggcttt
    10921 ctatcctcct ttggttaaat gcctttacca atctggtcaa tagtattcat gctttttaca
    10981 tgaccttatt ttagatagaa tgacagtata gaatggaagg aaatcatgtc tacaaataga
    11041 aaaaatgata tgatggttta ttgctcattt tgtggcaaaa accaagaaga agtacaaaaa
    11101 ataattgctg gcaacaatgc ttttatttgt aatgaatgcg tggagttagc tcaggaaatc
    11161 attcgagaag aattggttga ggaagtcttg gcagacttgt ctgaggtgcc aaaaccaatt
    11221 gaactcctcc atatcttgaa ccactatgta attggtcaag atcgtgccaa gcgtgccttg
    11281 gcagtggcgg tttataacca ctacaaacgc atcaatttcc acgatacacg cgaagagtca
    11341 gaagatgtgg atttgcagaa gtcaaacatt ttgatgattg gcccaactgg ttcagggaaa
    11401 actttccttg cccagacctt ggctaagagc ttgaatgtac cttttgctat tgcggatgcg
    11461 acagctctga cggaggctgg ttatgtgggt gaggatgtgg aaaatatact cctcaaactc
    11521 ttgcaggttg ctgactttaa catcgaacgt gcagagcgtg gcattatcta tgtggatgaa
    11581 attgacaaga ttgccaagaa gagtgagaat gtgtctatca cacgtgatgt ttctggtgaa
    11641 ggggtgcaac aagcccttct caagattatc gagggaactg ttgctagcgt accgcctcaa
    11701 ggtggacgca aacatccaca acaagagatg attcaagtgg atacaaaaaa tatcctcttc
    11761 atcgtgggtg gtgcttttga tggtattgaa gaaattgtca aacaacgtct gggtgaaaaa
    11821 gtcatcggat ttggtcaaaa caataaggcg attgacgaaa acagctcata catgcaagaa
    11881 atcatcgctg aagacattca aaaatttggt attatccctg agttgattgg acgcttgcct
    11941 gtttttgcgg ctcttgagca attgaccgtt gatgacttgg ttcgcatctt gaaagagcca
    12001 agaaatgcct tggtgaaaca ataccaaacc ttgctttctt atgatgatgt tgagttggaa
    12061 tttgacgacg aagcccttca agagattgct aataaagcaa tcgaacggaa gacaggggcg
    12121 cgtggacttc gctccattat cgaagaaacc atgctagatg ttatgtttga ggtgccgagt
    12181 caggaaaatg tgaaattggt tcgcatcact aaagaaactg tcgatggaac ggataaaccg
    12241 atcctagaaa cagcctagag gtgactatgg aacttaatac acacaatgct gaaatcttgc
    12301 tcagtgcagc taataagtcc cactatccgc aggatgaact gccagagatt gccctagcag
    12361 ggcgttcaaa tgttggtaaa tccagcttta tcaacactat gttgaaccgt aagaatctcg
    12421 cccgtacatc aggaaaacct ggtaaaaccc agctcctgaa cttttttaac attgatgaca
    12481 agatgcgctt tgtggatgtg cctggttatg gctatgcccg tgtttctaaa aaggaacgtg
    12541 aaaagtgggg gtgcatgatt gaggagtact taacgactcg ggaaaatctc cgtgcggttg
    12601 tcagtctagt tgaccttcgt catgacccgt cagcagatga tgtgcagatg tacgaatttc
    12661 tcaagtatta tgagattcca gtcatcattg tggcgaccaa ggcggacaag attcctcgtg
    12721 gtaaatggaa caagcatgaa tcagcaatca aaaagaaatt aaactttgac ccaagtgacg
    12781 atttcatcct cttttcatct gtcagcaagg cagggatgga tgaggcttgg gatgcaatct
    12841 tagaaaaatt gtgaggaaaa gaaaatggca aaaacaattc atacagataa ggccccaaag
    12901 gctatcggac cctatgttca aggaaaaatc gttggcaacc ttttgtttgc tagcggtcaa
    12961 gttcccctat cccctgaaac tggggaaatt gtaggagaga atatccaaga acagacagag
    13021 caagtcttga aaaacatcgg tgctattttg gcagaagcag gaacagactt tgaccatgtt
    13081 gtcaaaacaa cttgtttctt gagcgatatg aacgactttg ttccttttaa tgaggtttac
    13141 caaacggcct tcaaagagga attcccagct cgttcagctg tggaggtagc tcgtcttcct
    13201 cgtgatgtaa aagtcgaaat tgaagtcatc gcagagattg gataagctag ttgaagtttg
    13261 gtgttgccaa acttcttttg atataaggag aaaaagatga caaagaaaca acttcacttg
    13321 gtgattgtga cagggatgag tggcgcaggg aaaactgtag ccattcagtc cttcgaggat
    13381 ctaggttatt tcaccattga taatatgccg ccagctctct tgcctaagtt tttgcagctg
    13441 gttgaaatta aggaagacaa tcctaagttg gccttggtag tggatatgcg tagccgttct
    13501 ttcttttcag agattcaagc tgttttggat gagttggaaa atcaagatgg tttggatttc
    13561 aaaatcctct ttttggatgc ggctgataag gaattggtcg ctcgttacaa ggaaaccaga
    13621 cggagtcacc cactagcagc agacggtcgt attttagatg gaatcaagtt ggaacgtgaa
    13681 ctcttggcac ctttgaaaaa tatgagccaa aatgtggtgg atacgactga actcactcca
    13741 cgtgagctgc gcaaaaccct tgcagagcag ttttcagacc aagaacaagc tcagtctttc
    13801 cgtatcgaag tcatgtcttt cggatttaag tatggaatcc cgattgatgc ggacttggtc
    13861 tttgatgtcc gtttcttgcc aaatccctat tatttaccag aactgagaaa ccaaacgggt
    13921 gtggatgaac ctgtttatga ttatgtcatg aaccatcctg agtcagaaga cttttatcaa
    13981 catttattgg ccttgattga gccgattctg ccaagttacc aaaaggaagg taagtccgtt
    14041 ttgaccattg ccatgggatg tacgggtgga caacaccgta gtgtggcatt tgctaaatgc
    14101 ttggcgcagg acttatccaa gaattggtct gttaatgaag ggcatcgcga caaagaccgc
    14161 agaaaggaaa cggtaaaccg ttcatgagaa aaccaaagat aacggtgatt ggtggaggga
    14221 ctggaattcc cgtcattcta aaaagtctgc gggaaaaaga tgtggaaatc gcagctatcg
    14281 tgacggtggc agatgatggt ggttcttcag gtgaactccg aaaaaatatg caacagttga
    14341 caccgccagg tgatcttcgt aatgtccttg tggccatgtc ggatatgcct aagttttatg
    14401 agaaggtctt tcagtatcgg ttctctgagg atgccggagc ctttgctggc catccattgg
    14461 gaaatctcat cattgctggc ttgtcagaaa tgcagggttc aacctataat gccatgcagt
    14521 tattgagcaa atttttccat acaacaggga aaatttatcc ttccagtgac catcctttga
    14581 cccttcatgc agtctttcag gatgggacag aagtggttgg agagagtcat attgtagacc
    14641 atcgaggcat aattgacaat gtctatgtga ccaatgccct aaacgatgat acgcctctgg
    14701 ccagccgtcg agtagtgcag accatccttg aaagtgacat gattgtccta gggccaggtt
    14761 ccctctttac ctctattttg cccaatatcg tgattaagga aattgggcgg gctcttttgg
    14821 aaaccaaggc agaaattgcc tatgtctgca atatcatgac ccaacgtggg gagacggaac
    14881 actttacaga tagcgaccac gtggaagtct tgcatcgtca ccttggtcgc ccttttatcg
    14941 acactgtctt ggtgaatatt gaaaaagtgc ctcaggaata catgaattcc aaccgttttg
    15001 atgaatactt ggtgcaagtg gaacacgatt ttgtaggtct ttgtaagcaa gtttcgcgcg
    15061 tgatttcatc taacttcctt cgtctggaaa atggcggtgc cttccacgat ggagatttga
    15121 ttgtggacga gttgatgcgc attatacagg tgaaaaaatg agtttcacag tagcagtaaa
    15181 agaagaaatc ctgggccaac accatctgag ctggcatgaa ttatctgcca ttatcaaaat
    15241 gtctggtagc atcggtctct cgacttcggg cttgactttg tcagttgtga cagaaaatgc
    15301 caaactggcc cgtcacctct atgagtcctt tctccatttc tatgaaatca aatctgaaat
    15361 tcgtcaccac caacggagca atcttcgcaa gaatcgcgtc tataccgttt ttacagatga
    15421 aaaggtgcag gatttgttaa gtgatttgca cttggcagac tctttcttta gcctggaaac
    15481 aggtattgat gaggcgattt tatcggatga ggaagcaggt cgtgcctatc tctgtggcgc
    15541 tttcttggca aatgggagca ttcgtgaccc tgagtcaggc aagtaccagt tggaaatcag
    15601 ttctgtttat ctggaccacg cgcaaggaat tgcctccctt ctccaacagt ttttactgga
    15661 tgccaaggtg cttgagcgca agaagggggc tgtgacctat ctccagcgag cagaagacat
    15721 tatggacttc ttgatagtaa tcggagccat gcaggcacgt gatgattttg agcgggttaa
    15781 gattttgcga gaaacccgta acgacctcaa tcgggctaat aatgccgaga cagctaatat
    15841 cgctcggaca gtttctgcca gcatgaagac cattaacaat atcagtaaaa tcaaagatat
    15901 catgggctta gaaaatttgc cagtagattt gcaggaagtg gcgcaactga gaattcagca
    15961 cccagactac tctatccagc agttagcaga tagtctcagc acccctctga ccaaaagtgg
    16021 tgtcaatcac agactcagaa aaatcaataa gatagcggat gaattataaa accacgaatc
    16081 ctatgtgact cgtggttctt ttttataaac tagtagagtg ttttggttgt actttttgtt
    16141 cagggtcaat gtacttgata gcgttgttga cagcagttgg agcttctccg aggcctgtcg
    16201 caatcagatc aatttttccg tcatagtagc agcagtcacc gatagcatag atacctgctt
    16261 ggctggattc ctgtttgctg ttgacgataa tcttgtgacg gttgaggtcg agcccccagt
    16321 ttttaaggtt accgacagaa gatttgaaac catagttgac aaagaggtgg tctaggtcaa
    16381 tggtttcagt ttcatcagat ttgacttttg tgatttcaag tttagcaagt gtttttccat
    16441 ttccaaggag ttggctaggg gcgaatggtg tcttgatggt tacagatgat tcttgcaagg
    16501 cttgaacact gtgttccaag gcacggaaat tatctctgcg gtgaacaagg gtagttggtg
    16561 cgattttttc aaaagccaaa gcccaatcca cagccgagtc tcccccacca agaatcgtca
    16621 ctttcttacc agcgtattgc tgaatgttag aaacgtggta gtggatattt tcatagccct
    16681 caacaccttc aagttccagc ggacgtggtt tgaaggcacc gccacccata gcgatgatga
    16741 ctgttttagt caggtgactt cctttagaag ttgtgatggc aaattcttct tcttgtttgt
    16801 caatctcaag aaccgtttca ttgagatgaa taggggtatc aaatccattt agctgttcaa
    16861 tcaagcggtt agtcaactct tctccagtca ggtttgggaa gcctggtacg tctaggattt
    16921 ccttttcagg gtagagaata gcaggttgtc cacctagctg gggaagagag tcgatgattt
    16981 gaaccttggc ttggcgtagg tgggcataaa aggctgcaaa aagcccgaca ggaccaccac
    17041 ccacaatggt aatatcatag agttgagaca tagtttctcc tttgtttttt ctagtcagtt
    17101 tattttatca tatttttgtt caatgtaaaa tggactagga tagggaaaaa aatgccagaa
    17161 aatggtataa taggacgaaa gtgttttgat agggaggata tcagggatga attttcaaca
    17221 attatccaat ctgcaatatt ggaccagttt gtttgcaagt ccatggacga tagctatcaa
    17281 tctgattgat attttgattg ttgcttatat tttataccat tttacaaaag ctattgcagg
    17341 aaccaagatt atgattttgg tacgtggagt tttggtgttt attttagctc aaatccttgc
    17401 aaatatgatt ggtttgacta cgatttcttg gttaatcaat caaattatta cttatggggt
    17461 tattgcggcg gttgttatct tctctccaga gattcggact ggtttggaac gtttgggaag
    17521 agcgacagat ttcttttcca atgcccctat tagtgctgag gaacagatga ttcgtgcctt
    17581 tgttaagtct gttgaataca tgagtcctcg taaaatcggg gccttggttg ctattcagcg
    17641 tgtacgtacc ttgcaggagt atatttcgac aggaattccc ttggatgcta agatttctgc
    17701 agaacttctc attaacattt ttattcccaa cactccccta catgatggtg cggtgattat
    17761 caaagaagaa cgtatcgctg tgacgtctgc ctatctgccc ttgacaaaaa acacagggat
    17821 ttccaaggaa tttgggacta gacaccgggc ggctatcggt ttatcagaag tctcagatgc
    17881 cttgactttt gtcgtatcag aggaaacggg aggaatttcg ataacctata atggaaggtt
    17941 taagcacaac ctaacacttg atgaatttga aacagaatta cgtgaaatct tacttccaaa
    18001 agaggaagtg ggtcttagtt ttaaagaacg attgctagga ggatggaaac atgaaaaaaa
    18061 atagtttata tatcatatcc tcactctttt ttgcttgtgt cttatttgtc tatgctacgg
    18121 cgacgaattt tcaaaacagt accagtgcta ggcaggtaaa aacggaaacc tatactaata
    18181 cagtaacaaa tgtccctatt gacatacgct ataatagtga taagtatttt attagcggtt
    18241 ttgcttcaga agtatcagtg gtcttgactg gtgcaaatcg cctatcgcta gctagtgaaa
    18301 tgcaagaaag tacacgtaaa ttcaaggtta ctgctgacct aacagatgcc ggtgttggaa
    18361 cgattgaagt tcctttgagc attgaagatt tacccaatgg gctgaccgct gtggcgactc
    18421 cgcaaaaaat tacagtcaag attggtaaga aggctcagaa ggataaggta aagattgtac
    18481 cagagattga ccctagtcaa attgatagtc gggtacaaat tgaaaatgtc atggtgtcag
    18541 ataaagaagt gtcgattacg agtgaccaag agacattgga tagaattgat aagattatcg
    18601 ctgtcttgcc aactagcgaa cgtataacag gtaattacag tggttcagta cctttgcagg
    18661 caatcgaccg caatggtgtt gtcttaccgg cagttatcac tccgtttgat acaataatga
    18721 aggtgactac aaaaccagta gcaccaagtt caagcacatc aaattcaagt acaagcagtt
    18781 catcggagac atcttcgtca acgaaagcaa ctagttcaaa aacgaattaa aaatagaaaa
    18841 ggattttata acaatgggta aatattttgg gactgatgga gtccgtggag aagctaacct
    18901 agaactaaca ccagaattag cctttaaact aggacgtttt ggaggctatg ttcttagtca
    18961 acatgaaacg gaagcgccga aagtctttgt aggacgtgac acacgtattt caggggaaat
    19021 gctggaatcg gccttggtgg caggtctcct ttcagtaggg attcacgtat acaaacttgg
    19081 tgtccttgca acaccagcag tagcttactt ggttgaaact gaaggagcaa gtgccggtgt
    19141 catgatttct gctagccaca acccagccct tgataacgga atcaagttct ttggcggtga
    19201 tggcttcaaa ctagatgatg aaaaagaagc agaaattgaa gccttgctag atgctgagga
    19261 agacactctt cctcgtccaa gtgcagaagg cttaggaatt ttggtagatt atccagaagg
    19321 cttgcgtaag tatgaaggat accttgtttc aactggaact cctcttgatg gaatgaaggt
    19381 tgccttggat acagctaatg gagcagcttc taccagtgcc cgtcaaatct ttgcagacct
    19441 tggtgcccaa ttgacggtta tcggggaaac accagacggt cttaacatca accttaatgt
    19501 tggttcaaca catccagaag cccttcaaga agtggtcaaa gaaagtgggt cagctattgg
    19561 tttggccttt gatggagaca gtgatcgctt gattgctgtt gatgagaatg gtgacatcgt
    19621 cgatggtgac aagattatgt acatcatcgg aaaatacctt tctgaaaaag gacaattggc
    19681 tcaaaataca attgtgacaa ctgttatgtc taaccttggt ttccacaagg ccttgaatcg
    19741 cgaaggtatt aacaaggcag ttactgcagt tggtgaccgc tacgttgttg aagaaatgag
    19801 aaaatcaggc tacaaccttg gtggtgaaca gtctggtcac gttatcttga tggattacaa
    19861 taccacaggt gatggtcaat tatcagcagt tcaattgact aaaattatga aggaaactgg
    19921 taagagctta tcagagttgg cggcagaagt aacgatttat ccacaaaaat tagttaatat
    19981 ccgagtggaa aacgtcatga aggaaaaggc catggaagtg ccagctatca aggccatcat
    20041 cgagaagatg gaagaagaaa tggcggggaa cggccgtatc cttgttcgtc caagtggaac
    20101 agagcccctc ttgcgtgtta tggcagaagc gcctacaaca gaagaagtgg actactatgt
    20161 tgataccatc acagatgtag ttcgtgctga aattgggatt gactaaatcc tagaaaacta
    20221 gatgaaaata aaaaattatg gtacaatagc ttataatatt gtagccgatg gagaaagaca
    20281 tgaatcttaa acgtgaacaa gaatttgtta gtcagtatca ttttgatgcg cgtaattttg
    20341 aatgggaaaa tgaaaatgga gctcctgaaa ccaaggtgga tgtgaatttc caattgctcc
    20401 aacatgacca agaaaatcaa gtgacttcct tgattgtcat cttgagcttt atgattgtat
    20461 ttgataagtt tgtcattagt ggaacaatct cacaagtaaa ccatatcgat ggccgtattg
    20521 tcaatgaacc aagtgaattg aaccaagaag aggtggaaac cttggctcgt ccatgtttga
    20581 acatgctcaa tcgtttgact tacgaagtga ctgaaattgc attagactta ccaggaatta
    20641 atttggagtt ctaatatgaa attagctgtt ttcacagatt cctctgctta tctcagtgca
    20701 gagaccttgc aaagagaaga cttgtttgtc ttggatattc ctgtcaatat tgatggtgag
    20761 gaatatgtcg aaggcatcaa tctgtctgct gaggaatttt accaaaaaat ggctcaggct
    20821 tctgaattgc ctaagaccag tcaaccaagt attgccaagt tagatgagat cttaacttcg
    20881 ctcaaagaac aaggctatac acatgccttg gggcttttcc tatcttctgg aatttcaggt
    20941 ttttaccaaa atatccagta tatggtcgat gactatgagg gcttaaccat tgctttccca
    21001 gacactttga ttacaagtgc tcccctaggc atcatggttg aaagcgtctt taattggcgt
    21061 gatcagggcg atgattttgc cagcattcag gataagctag ccattcaaat cagccgtacg
    21121 tcagccttta tcatggtaga tgacttggat catttggtaa aaggtggacg cctttcaaat
    21181 ggggctgcca ttttgggcaa tttgcttagc attaagccaa tcctttattt taacgatcaa
    21241 ggtatgattg aagtttacga aaaagttcgt actgaaaaga aggccaccaa gcgcttaatt
    21301 gaaattatca aggaaacaac ggcttcaggt caataccggg tcattgtcat tcatgggaat
    21361 gctcctgaaa aggctgaaga attgcgtcag catttgcttg attttggctt gggttcggat
    21421 gtttcacttg ctacatttgg tagtgtcatt ggaacgcacc taggatcagg aagtattgct
    21481 ctgggttata ttccagtgat ttagttggcg cttctaggct agttaagatg ccttgtatct
    21541 tagaaattga acacggacta cctgcctctt gaaaaaagat gcctgtcttg cctttcgtgg
    21601 aaagtcagtg ccattcccta tttttcagag gcagctaagg tcctttgtat cttgataatt
    21661 gaacacgcct ggaaccctgt gtgaaaaaga tagttcttcc aagaagtaga cacttcttga
    21721 ttggaattcc tattttcact ttgtgttctt acggactttg tatcttagac aggagtagag
    21781 atgagtattc gagtaattat tgccggtttt aagggaaaga tgggccaggc tgcttgtcag
    21841 atggtattga ctgatccaga cttggacttg gtagcagttt tggatccttt tgagtctgag
    21901 tcagaatggc agggtattcc tgttttcaag gataaggctg atttagctgg ttttgaagcg
    21961 gatgtctggg tagattttac tactccagct gttgcctacg aaaatacacg ttttgctctt
    22021 gaaaatggct ttgctccagt agttggaacg actggtttca cgagtgaaga aattgcagag
    22081 ctaaaagaat tttctcgtgc ccaagacttg ggtggcctga ttgcccctaa ctttgccttg
    22141 ggtgctgtct tactcatgca atttgcgacg caggctgcca aatatttccc aaatgtggag
    22201 attattgagc tccatcatga caagaaaaag gatgctccga gtggaacagc cattaaaaca
    22261 gctgagttga tggcagaggt tcgagagtca attcagcaag gtgcagcaga tgaggaagag
    22321 ctgattgctg gtgctcgtgg tgctgacttt gatggtatgc gcatccactc agttcgtttg
    22381 ccaggcttgg tagctcatca ggaagtcatc tttggcaatc agggagaagg gttgaccctc
    22441 cgtcatgact cctatgatcg catctccttc atgacaggag tcaatttggg aattaaagaa
    22501 gttgtcaagc gtcatgagct tgtctatgga ttagaacact tattatgaga ttaacgcaaa
    22561 tgccttctga atttcagaag gctttaccag tattagaaaa aattaaagaa gcaggctttg
    22621 aggcttattt tgttgggggc tctgttcgag atgcccttct ccatagccct atccacgatg
    22681 tggatattgc gacgtcttct tatccagaag agaccaagca gatttttccg cgaacagccg
    22741 atatcggaat cgagcatgga accgtcttgg tcttagatgg ggatgaggag tatgaggtaa
    22801 caacctttcg gacagaggat gtctatgtgg actatcgcag acccagtgcg gtttcctttg
    22861 tacgatcgct agaagaagac ctcaaacgcc gtgatttcac agtcaacgcc tttgccttgg
    22921 atgagacagg agaaatcgtt gacttgttcc atggtttaga agatttggaa aagcaagtct
    22981 tgcgagcagt tggagtggct agtgagcgtt tcaacgaaga tgctttacgg attatgcgtg
    23041 gtttccgttt tcaggctagt cttggttttg cacttgagcc agaaacattt aaagctatga
    23101 agaccttgac gccgcttttg gagaaaattt ctgtagagcg taccttcgtc gagtttgata
    23161 aactcttgct ggctccattt tggagaaggg gcttggcttc catgattgag agtcaagctt
    23221 atgactatct ccctgatatg gcatctagcc aggacaagct caacagactg tttgatttgg
    23281 agactgattt tacttttgaa tcctctgaac aagcctgggc ggctttacta tgggctttgg
    23341 agattgaaaa tgcgcagtca tttttgaaat cttggaagac ctcacgccag tttgccaagc
    23401 aagttcagga tttgctgatt attttggctc tgcgtgaaaa tggagaattg agcaagcgag
    23461 attgttatcg ctttgacata gatttgcttt tacaggctga aaatcttcgt caagctcaag
    23521 gaaaagaagt caacccacaa gccatcacag aaaaatacca aagcttgact atccatgaca
    23581 agaaagagat tcagattaat ggcggtattt tgatcaagga atatggctat cagccaggcc
    23641 cagacttggg agagatttta acagagattg agtttgccat tgtcgatgga gaattggaga
    23701 ataatcgtga agccatccat gcttacctga gggagaaaaa atgagtgatt ttatcgttga
    23761 aaaactaact aaatccgttg gtgacaagac cgtttttagg gatatttcct ttattatcca
    23821 tgacttagac agaattggtc taatcggtgt caatgggact ggcaagacca cccttttgga
    23881 cgtcctttct ggtgtttctg gatttgatgg ggatgtcagt cctttttcag ctaaaaatga
    23941 ttaccagatt ggttacttga ctcaggatcc tgattttgat gatagaaaga cagttttgga
    24001 tacggttcta tctagtgaac tcaaggaaat ccagctcatt cgtgagtatg aattgattat
    24061 gctcgactat agtgaggaca agcaggcgcg tttggaacgt gtcatggcag agatggactc
    24121 tctccaagct tgggaaatcg agagtcaggt caagaccgtt cttagcaaat tgggcattca
    24181 agacttatct actcctgttg gggaattgtc aggtggtctg agaagacggg tacagttggc
    24241 acaagtctta cttggcaacc acgatctttt gcttttggat gagccgacca accatctgga
    24301 tattgcgatt attgagtggc tgaccctctt tttgaaaaat tctaagaaga ccgtcctttt
    24361 tatcactcac gatcgttatt tcttagacgc tttgtcaaca cggattttcg agttggagcg
    24421 agcaggcttg acagaatatc agggcaatta ccaggactat gttcgcctta aggcagaaca
    24481 ggacgagcgc gatgcagctc tacttcataa aaaagaacaa ctctacaaac aagaactggc
    24541 ctggatgcgc agacaaccac aggcacgtgc gaccaagcaa caagctcgta tcaatcgttt
    24601 ccatgatctg aaaaaggaag tttcaggcag tagtgctgag acagacttga ctatgaactt
    24661 tgaaaccagt cggattggga agaaagtcat cgagtttcag gatgtttcct ttgcctatga
    24721 aaataagccc attttgcaag attttaatct cttagttcag gctaaagacc gtattggaat
    24781 tgttggggac aatggtgttg gaaaatcaac cctacttaac ctgattgcag gaagtcttga
    24841 gccgacagca ggacaagttg tgattgggga aactgttcgc atcgcctatt tctctcaaca
    24901 aattgagggt ttggatgaaa gcaagcgtgt gatcaattac ctgcaggaag tggcagagga
    24961 ggtcaagacc agtggtggtt ctacgacttc catcgctgag ttgctggagc aattcctctt
    25021 cccacgttcg acgcatggga ccttgattga gaaattgtca gggggtgaga aaaaacgtct
    25081 ttatctcctc aaactgcttt tggaaaaacc aaatgttctt cttttagacg agccaaccaa
    25141 tgacctagat attgcaactt tgacagtctt agagaatttc ttgcaaggtt ttgcaggtcc
    25201 cgttttaaca gtcagtcacg accgctattt cttggataag gtagcgacca agattctcgc
    25261 ttttgaggat ggcaagattc gtcctttctt tggtcattac accgactatc ttgatgaaaa
    25321 agcttttgaa acagatatgg ccaatcaagt gcaaaaggcc gaaaaggaaa aagtggtcaa
    25381 ggttcgagaa gacaagaaac gcatgaccta ccaagaaaag caggagtggg caagtattga
    25441 aggtgatatt gaaaccttgg aaaaacgtat cgctgctatt gaagaggaaa tgcaggctaa
    25501 cggctctgac tttggtaagc tggctactct ccaaaaagaa ttggatgaga aaaatgaagc
    25561 actccttgaa aaatacgaat gctatgagta tctcagtgaa tttgatagtt aagactattc
    25621 gaaaatcaaa gtgcaaacta tgtcggcttc acattgccga ctcaagtaca gcctgtgacc
    25681 ggcttcctaa tttgcacttt gatttttatt gagtataaaa gaatagaaaa atcccgtctc
    25741 atgaaaggat ttctctattc ttttttggtt tcttgatgaa agatattttg ccaggtttcg
    25801 tggcgacgcc agatactggt atggatgata ccatctaact catagcagat gagtttggtt
    25861 ttttgactga tggaagtaat ttgaatgtcc ttgatagcag aatttaactc ttttttggtc
    25921 ttataagcct ctttatccat ctgctctcca tcttggcgaa tatagacaaa atcatcagtc
    25981 aagagttctt ctagttggtt tccttggtca atcaattgtt cacgcataag caatttttta
    26041 tagacattgt ctaaaatttc atcctcaggg ataggtgctg gttcgatatg gacatcggta
    26101 tcaaagacgc caaaacgctc ctccagcata gactcgacct gatccgcgat ttcatggctt
    26161 tcaaaaacag acaagtcagg attcatctct agtgtaatat ccaggtagat gttgctaccg
    26221 taggtgcgac ctctttgcga tttgaccttg ctgattttgg gaatttccat gatagccttt
    26281 tggtagtcct cgagcaggcg gtcgtcaaag ccatctgaaa gactaaagga agactcgatg
    26341 aagatatcat aggcagtctt caagataaag aaagtgatga taatagcaac cagtttatcc
    26401 acaatcggat aattaaaact actagctagg atggcaatgg cggttccaag tgaggtaaca
    26461 gcgtcagaaa gattgtcctt agcagctgcc ttcagcgcct tggagttgga tttcttactg
    26521 aggcgagtat tgtagagata gaccacaaac ataatcgctg cagaaatgat tcctagagtt
    26581 gcaccaagag gatcaatgac cgtttcttcc cgactgagaa tcttttgaat ggtatctctt
    26641 agaacatcga aaccgacata gaacatgatg atagaagtga tcaagcttgc caaatcttca
    26701 atcttccaat gaccaaaacg gtggtcacgg tctgcaggct ggcgcgccat ccgaatcccg
    26761 attaagaggg ccacatttcc aatgatgtcc gatacgttat taaaaccatc ggccaccaaa
    26821 ctggatgaat gaaggagatg accagctgct aatttggctg cagacaagat caaataggtc
    26881 gaaatactga taatggctcc acgctcagct aacttgagat ttgagataga ttgcttcatt
    26941 caacttcctt tctagtcaca tagcattcta ccattatact ggttttcaag gaaaaattca
    27001 aataaggcag tttttactct ttgaaaactc cccaaaattt ggtataatgg tactactcaa
    27061 gggagtagct ggcagaaacc tgtgatagtg tcgtcattcc gaattttatg ctgaaaagta
    27121 tgctttccgg ccctatctta aacagcgaga cttgttatga ttaacaggtc tctttttgtt
    27181 tgtcgtgaaa agatatgaca gaaagagagt ctgttttgca cacaatgtca aggaggagac
    27241 acatgtcaaa agaacaaaaa cgccaagcgt tttatactca gagccctgaa gaggtcttgc
    27301 aggctgtgga tgcgaccgag caaggtttgt catcaagtga ggcggaaaag cgccttgccg
    27361 aatttgggca caatgaactc gaagaaggcg agaaacgatc aatcttggtc aaattcatcg
    27421 agcaatttaa ggatttgatg attatcatcc tagttgcggc agcaatcttg tcagtcgtga
    27481 cttctggtgg ggaagatatc gcagatgcca ttatcatcct agctgtggtt atcatcaacg
    27541 ctgcctttgg tgtttaccaa gaaggaaaag ctgaagaagc tattgaagcc ctcaaatcca
    27601 tgtctagtcc agttgcccgc gttcttcgtg atggacacat ggcagagatt gactctaaag
    27661 aattggtacc aggcgatatc gttgcccttg aagcaggtga cgtggtacca gcggacctac
    27721 gtttgataga agccaactct cttaaaattg aagaagcagc cttgacaggt gaatctgtac
    27781 cagtcgaaaa agacttgtca gtcgagcttg cgacagatgc tggtattggt gaccgtgtca
    27841 acatggcctt ccaaaactca aacgtaacct atggtcgtgg gatgggtgtt gttgtcaata
    27901 caggtatgta cactgaagtt ggtcatattg ctggtatgct tcaagatgcg gatgagactg
    27961 atacaccact caaacaaaat ttgaacaacc tttctaaggt cttgacctat gctatcttgg
    28021 tcattgccct tgttactttt gtagtgggtg tcttcattca agggaaaaat ccacttggtg
    28081 agttgttgac ttctgttgcc cttgccgttg cagccattcc agaaggactt cctgctatcg
    28141 ttaccatcgt tctttctctt ggtactcaag ttttggccaa acgacattcc atcgttcgta
    28201 agttgccagc agttgaaaca cttggttcaa ctgaaatcat cgcttctgat aagactggta
    28261 cgctgactat gaacaagatg acagtcgaaa aagtcttcta cgatgcggtt ctacatgact
    28321 cagctgatga tattgaacta ggtcttgaaa tgccactact tcgttcagtt gtcttggcca
    28381 atgatacgaa aatcgatgtg gaaggtaact tgattggtga cccaaccgaa acagccttta
    28441 tccaatatgc cttggacaag ggctatgatg tcaaaggttt cttagagaaa tatcctcgtg
    28501 tagctgaatt gccatttgac tctgaccgta agctcatgtc aacagttcac ccattgccag
    28561 atggtcgttt ccttgtagca gtcaagggtg cgccagacca actcttaaaa cgttgtcttc
    28621 ttcgtgataa ggctggggat attgctccga ttgatgagaa ggttacaaat ctcattcata
    28681 caaacaattc tgaaatggct catcaagcct tgcgtgtcct tgcaggtgct tataagatta
    28741 tcgatagtat tccagaaaat ctcacttctg aagagcttga aaatgattta atttttactg
    28801 gtttgattgg gatgattgac cctgaacgtc ctgaagccgc tgaggctgtt cgtgtggcta
    28861 aggaagcggg aatccgtcca attatgatta caggtgacca ccaagacaca gcggaagcca
    28921 ttgccaaacg tttgggaatc attgacgcaa acgatacaga aggtcacgtt ttaactggtg
    28981 ctgaactcaa tgaactgtca gatgaagaat ttgaaaaagt cgttggtcaa tactctgttt
    29041 atgcccgtgt gtctccagaa cacaaggttc gtatcgtcaa ggcttggcaa aaacaaggta
    29101 aagtcgttgc catgacaggt gacggtgtca atgacgcgcc agctctgaaa acagccgata
    29161 tcggtatcgg tatgggaatc actggtacag aggtttctaa gggggcttct gatatgattc
    29221 ttgcagatga taactttgcg actattatcg tcgcagtgga agaaggacgt aaggtcttct
    29281 caaacattca aaagactatt cagtacctac tttctgctaa tactgctgaa gtattaacca
    29341 tcttcctatc aaccttgttt ggttgggatg tcttacagcc ggttcatctt ttgtggatca
    29401 acttggtaac ggataccttc ccagctatcg ctcttggtgt tgaacctgcg gaacctggtg
    29461 tcatgaatca taaaccacgt ggacgcaagg caagcttctt ctcaggtggt gttttgagtt
    29521 ctatcattta tcaaggtgta ctccaagcag ctcttgttat gagtgtttat ggccttgcga
    29581 ttgcttaccc agttcatgtg ggtgacaatc atgctattca tgcagatgcc ctaacgatgg
    29641 cctttgcaac ccttggtttg attcagctct tccatgccta caatgtcaag tctgtctacc
    29701 aatccatctt gacagttggc ccattcaagt ctaagacctt taactggtcc atcttggtat
    29761 cctttatcct tctcatggca acaatcgttg tagaaccgct tgaaggaatc ttccacgtaa
    29821 ccaaactaga cttgtcacaa tggggaattg ttatggctgg aagcttctca atgattatca
    29881 tcgtcgaaat cgttaagttt actcaacgca aactcggttt tgacaagaat gcgatttaag
    29941 ggaggtttcg gatgtcagca tatcaattac cgaccgtatg gcaggatgaa gctagtaatc
    30001 aaggagcttt tacggggcta aacagaccaa cagcaggtgc ccgtttcgaa caaaacttgc
    30061 caaaaggaga acaagctttt cagctttatt cactgggaac accaaatggt gtgaaggtta
    30121 ctatcttatt ggaagaatta ctagaagctg gttttaagga agcggcttac gacttgtata
    30181 agattgctat catggatggg gatcaattcg gctcagactt tgtgaagctc aatccaaatt
    30241 ccaagattcc agccttattg gaccagtcag gtactgaaaa cgtaagagtc tttgagtctg
    30301 ctcatattct tctttacctt gctgagaaat ttggagcctt tttaccaagt aatcctgtgg
    30361 aaaaggtaga agttttgaat tggctattct ggcaagtagg tgcagcacct tttctaggtg
    30421 ggggatttgg acatttcttc aattatgctc ctgaaaaatt ggaatatcct attaaccgtt
    30481 ttacgatgga agtgaaacgc cagttggatt tattggataa ggaattggct cagaaacctt
    30541 atattgcagg caatgactat acgattgcag atattgctat ctggtcttgg tatggacagt
    30601 tagttcaagg aaatctttac caaggttctg caaaattctt ggatgcctca agttatcaaa
    30661 atctagtaaa atgggcagaa aaaattgcca atcgtccagc tgttaagcgt ggcttggaag
    30721 taacttatac agaaattaaa tagcaaaaaa gtcatcttcg gatggctttt tgctacagtt
    30781 gagggaaagg gtttgcagtt atcggctttt gtgctataat tgctataata tagtaaaaag
    30841 caagaggagt gtgaggaagt ggaaaagaaa attgtgaagg atatcttatt tttatctcaa
    30901 gtgtctcagc cggcaagtca ggaggacctt tatcttgcca gagatttgca ggatacactc
    30961 ttagcaaatc gtgatacctg tgttggtcta gctgccaata tgattgggat gcagaagcgc
    31021 gtgattatct ttaatcttgg cttggttccc gtggtcatgt ttaacccagt gcttctgtcc
    31081 tttgaaggat cctatgaggc agaagaaggc tgtttgtcct tggtaggtgt gagatcaact
    31141 aagcgttatg aaaccataag gcttgcctat cgtgacagca agtggcagga acagaccatt
    31201 accttgacag gcttcccagc tcagatttgc cagcatgagc tggatcactt ggaaggacga
    31261 atcatttagg aggaaagcaa atgaaacgaa tagtctttga acttattttt atcgcaacga
    31321 cctggtatat ctttttaccg ccccttaacc tgaccagctg ggaatttctc ttcttcctct
    31381 gtgggcattt gttagttgtg gcaatcttat ttggctttgg caaggggata aaccttgtca
    31441 aaacggttca tgtgcgccac ggtaaggcgg aagctgcctt aaatcttgag ggtttcaaaa
    31501 tcaatcggtt agggaaaatt ctgttagctt cgattggagg aattcttctc ttggcagctt
    31561 tggtttcctt ggtaacttct agcatgtttc aggctaaaaa ttatgccaat gtagtcacgg
    31621 ttacggaaaa agactttact gaatttccta agagtgacac cagtaaggtt cctatcctag
    31681 atagaagtac tgctgaaaaa attggagacc gctacttggg ttccctaacc gataaggtgt
    31741 cgcaatacgt agcggcagat acctataccc aattgacaat tgatgggaaa ccttatcggg
    31801 tcacaccact agaatatgca gaccctatca aatggtttaa caatcaagcc aagggaatcg
    31861 gtgagtatat caaggtggac atggtaactg gaaatgcgga tttggtggac ttgaagacac
    31921 caatcaagta ttcagactcg gagtatttta accgtgatgt caaacgtcac ctgcgcttga
    31981 agtacccgac caaaatcttt aaaactccat cttttgaggt ggacgatgag ggcaatcctt
    32041 tctatgtagc aacggtttac caaaagcaat ttggacttgc ggttcctcgt cctgcttcag
    32101 tcattatctt ggatgctaca aatggagaaa ccaaggaata cagcttatca gacgttccag
    32161 aatgggtgga caggatctat ccagcagagg aaaccattga gcaaatcaac tacaacggca
    32221 agtacaagga cggtttcttg aatgccatga tttccaagaa aaacgtgacc cagactacca
    32281 atggctataa ttacttgtct atcggtaatg acatctatct ctacacaggt gtgacgtcgg
    32341 ctaatgcgga tgagagtaat cttggtttca tccttgaaaa tatgcgaaca ggagaaatca
    32401 ctaagtatag cttggcttct gcgacagaag aatcagcccg tgaatcagca gaaggtgctg
    32461 ttcaggagaa atcctacaaa gcaaccttcc caattctcat caacctcaat gacaagcctc
    32521 tctacatcat gggcttaaag gacaatgctg gcttgatcaa agagtacgcc ctggtagacg
    32581 cagtcgagta ccaaaatgtt atcgttgcta ctacagtgga agagatgctc agcaagtatg
    32641 ccaataaaaa cgaccttgaa attgacaatg caacgacaga aagcatcaag ggagtagtag
    32701 cagacctcaa atcagctgtt atcaagggag acactgtcta cttctttaaa gttgatggca
    32761 agatatacaa ggtaaaggct tcagtatccg atgaccttcc ttaccttgaa aatggtaaaa
    32821 ccttcgaagg tcaagtagga aaagacaatt atctcaagac ctttaaagta caataatact
    32881 cttcgaaaat ctctagctct atctgcaacc tcaaaacagt gttttgagca gcctg
//
LOCUS       DAVHSO010000021        32804 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.021, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000021 DAVHSO010000000
VERSION     DAVHSO010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32804)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32804)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32804
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.021"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(163..1260)
                     /locus_tag="VVR18_000937"
     CDS             complement(163..1260)
                     /locus_tag="VVR18_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HEU6032489.1"
                     /translation="MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAI
                     VDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVDILDRLGIDSLVFGTEEVRD
                     YQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYA
                     KAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQA
                     SKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRY
                     TKARVRRLLTYILVQARENVLPEAIHVLGFTEKGRQHLKYLKGQVSLVSRIGKEPWDV
                     MTQKADQIYQLGNPSIAEQNFGRVPIRIETN"
     gene            complement(1270..2016)
                     /locus_tag="VVR18_000938"
     CDS             complement(1270..2016)
                     /locus_tag="VVR18_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000605145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU6032490.1"
                     /translation="MIMATYETFAAVYDAVMDDSLYDKWTNFSLRHLPKTKEKKKLLE
                     LACGTGIQSVRLSQAGFDVTGLDLSADMLKIAEKRATSAKQKIAFIEGNMLNLSKAGK
                     YDFVTCYSDSICYMQDEVEVGDVFKDVYNALNEEGVFIFDVHSTYQTDEVFPGYSYHE
                     NAEDFAMLWDTYEDEAPHSIVHELTFFIKEADGSFSRHDEVHEERTYEILTYDILLEQ
                     AGFKSFKLYADFEDKEPTETSTRWFFVAQK"
     gene            complement(2119..2472)
                     /gene="rsfS"
                     /locus_tag="VVR18_000939"
     CDS             complement(2119..2472)
                     /gene="rsfS"
                     /locus_tag="VVR18_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HEU6032491.1"
                     /translation="MNEKELLELVVKAADEKRAEDILALDVQDLTSVTDYFVITSSMN
                     SRQLDAIAANIREKVAQAGFKGSHVEGDAAGGWVLLDLGAVVVHIFSEEMRAHYNLEK
                     LWHEANSVDISEALA"
     gene            complement(2485..2985)
                     /locus_tag="VVR18_000940"
     CDS             complement(2485..2985)
                     /locus_tag="VVR18_000940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEU6032492.1"
                     /translation="MKTAFIIIDVQNVLVETGFQTKSLLGKISYLQNQARSKNIEIIY
                     VQHIENSEAQTSEDWQLSALLNRKPAEKVFQKKYNSIFKETGLKEYLDKQGIEKLVLC
                     GMQTEYCVDTSVKVAFEYGYQLIVPEGAVTTFDGDDIPAETINEFYEDIWEEHFADVL
                     DYKHIF"
     gene            complement(2986..3579)
                     /gene="yqeK"
                     /locus_tag="VVR18_000941"
     CDS             complement(2986..3579)
                     /gene="yqeK"
                     /locus_tag="VVR18_000941"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HEU6032493.1"
                     /translation="MSYQDYINCSREVLLEKMAELLPEKRLTHCLGVERAAMELAQRF
                     GVDVEKASLAGLLHDYAKKLSDQEFLALIDRYQLDFDLKNWGNNVWHGMVGIYKIQED
                     LDLHDSEILRAIEVHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIASLSLNKA
                     VAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKEN"
     gene            complement(3579..4208)
                     /locus_tag="VVR18_000942"
     CDS             complement(3579..4208)
                     /locus_tag="VVR18_000942"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HEU6032494.1"
                     /translation="MTIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVA
                     DQVRQQLGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIDGLVIETIELERK
                     GISYTYDTMKILTEKNPDTDYYFIIGADMVDYLPKWYRIDELVDMVQFVGVQRPRYKA
                     GTSYPVIWVDVPLMDISSSMVRDFIAQGRKPNFLLPQPVLDYIEKEGLY"
     gene            complement(4260..4571)
                     /gene="yhbY"
                     /locus_tag="VVR18_000943"
     CDS             complement(4260..4571)
                     /gene="yhbY"
                     /locus_tag="VVR18_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome assembly RNA-binding protein YhbY"
                     /protein_id="HEU6032495.1"
                     /translation="MSLTSKQRAFLNSQAHTLKPIIQIGKNGLNDQIKTSVRQALDAR
                     ELIKVTLLQNTDENIHEVAEILEEEIGVDTVQKIGRILILFKQSSKKENRKISKKVKE
                     I"
     gene            complement(4785..5891)
                     /gene="yqeH"
                     /locus_tag="VVR18_000944"
     CDS             complement(4785..5891)
                     /gene="yqeH"
                     /locus_tag="VVR18_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391231.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="HEU6032496.1"
                     /translation="MEEILCIGCGATIQTTDKAGLGFTPQSALEKGLETGEVYCQRCF
                     RLRHYNEITDVQLTNDDFLKLLHEVGDSDALVVNVIDIFDFNGSVIPGLPRFVSGNDV
                     LLVGNKKDILPKSVKSGKISQWLMKRAHEEGLRPVDVVLTSAQNKHAIKEVIDKIEHY
                     RKGRDVYVVGVTNVGKSTLINAIIQEITGDQNVITTSRFPGTTLDKIEIPLDDGSYIY
                     DTPGIIHRHQMAHYLTAKNLKYVSPKKEIKPKTYQLNPEQTLFLGGLGRFDFIAGEKQ
                     GFTAFFDNELKLHRSKLEGASAFYDKHLGTLLTPPNSKEKEDFPRLVQHVFTIKDKTD
                     LVISGLGWIRVTGIAKVAVWAPEGVAVVTRKAII"
     gene            complement(5894..6484)
                     /locus_tag="VVR18_000945"
     CDS             complement(5894..6484)
                     /locus_tag="VVR18_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="HEU6032497.1"
                     /translation="MDCFILVTKENCEKKLRKGARMAIENYIPDFAVEAVYDLTVPSL
                     QAQGIKAVLVDLDNTLIAWNNPDGTPEMKQWLHDLRDAGIGIIVVSNNTKKRVQRAVE
                     KFGIDYVYWALKPFTFGIDRAMKEFHYDKKEVVMVGDQLMTDIRAAHRAGIRSILVKP
                     LVQHDSIKTQINRTRERRVMRKITEKYGPITYKKGI"
     gene            complement(6436..7344)
                     /locus_tag="VVR18_000946"
     CDS             complement(6436..7344)
                     /locus_tag="VVR18_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEU6032498.1"
                     /translation="MVLEKQLGNGCTWIDLDLGKLNKLEDLSEIYGLDKETIEYALDR
                     NERAHMDYHRESGTVTFIYNVLDVKKDKAYYETFPMTFIVEHRRLITISNTKNAYVIE
                     QMTRYLENHDTLSIYKFLFASLEIISNAYYPVIEQMDKSRDEVNDLLRQRTTKKNLFA
                     LSDLETGMVYLTAAAKQNRILLEHIQGHALYRSFDEIEREQFDDAMIEAHQLVSMTDL
                     ISQILQQLSASYNNILNNNLNDNLTTLTIISVLLAVLAVVTGFFGMNVPLPLTDEPHA
                     WLYISLASAGLWIVLSLLLRKIAKKS"
     gene            complement(7401..7961)
                     /locus_tag="VVR18_000947"
     CDS             complement(7401..7961)
                     /locus_tag="VVR18_000947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="HEU6032499.1"
                     /translation="MQKFIQAYIEKLDVTTIIENILTKVISLLLLLIVFYIAKKMLHT
                     MVQRIVKPSLKMSRHDVGRQKTISRLLENVFNYTLYFFLLYCILSILGLPVSSLLAGA
                     GIAGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNGPITVSGKVVSVGIRTTQ
                     LRSEEQVLHFVPNRNITVVSNFSRTD"
     gene            8100..9318
                     /gene="sstT"
                     /locus_tag="VVR18_000948"
                     /pseudo
     CDS             8100..9318
                     /gene="sstT"
                     /locus_tag="VVR18_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713440.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine transporter SstT"
     gene            9386..10339
                     /locus_tag="VVR18_000949"
     CDS             9386..10339
                     /locus_tag="VVR18_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEU6032500.1"
                     /translation="MSISQRTTKLILATCLACLLAYFLNLSSAVSAGIIALLSLSDTR
                     RSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLYLAFYVPLAYKMGWEIGITPS
                     TVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLK
                     DILQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMR
                     QRQSRILRNMAQQINTCHLAASESLILAQLFSKIAGQLSQTNPASDLLDEIERYLEVF
                     RNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYGQ"
     gene            complement(10665..10745)
                     /locus_tag="VVR18_000950"
                     /pseudo
     CDS             complement(10665..10745)
                     /locus_tag="VVR18_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(10800..11024)
                     /locus_tag="VVR18_000951"
     CDS             complement(10800..11024)
                     /locus_tag="VVR18_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory secretory protein Asp5"
                     /protein_id="HEU6032501.1"
                     /translation="MIDILIVLAIILSLALIVLVTIQPRQNQLFSMDATSNIGKPSYW
                     QSNTLVKVLTLLVSLALFVLLLTFMVITYK"
     gene            complement(11029..11208)
                     /gene="asp4"
                     /locus_tag="VVR18_000952"
     CDS             complement(11029..11208)
                     /gene="asp4"
                     /locus_tag="VVR18_000952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory secretory system protein Asp4"
                     /protein_id="HEU6032502.1"
                     /translation="MSEEDLFYKDVEGRMEELKQKPIKKEKETRGEKISKTFSLLLGL
                     MILIGLLFTLLGILR"
     gene            complement(11210..12547)
                     /gene="gtfB"
                     /locus_tag="VVR18_000953"
     CDS             complement(11210..12547)
                     /gene="gtfB"
                     /locus_tag="VVR18_000953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system glycosylation chaperone
                     GtfB"
                     /protein_id="HEU6032503.1"
                     /translation="MIELYDSYSQESRDLHESLVATGLSQLGVVIDADGFLPDGLLSP
                     FTYYLGYEDGKPLYFNQVPVSDFWEILGDNQSACIEDVTQERAVIHYADGMQARLVKQ
                     VDWKDLEGRVRQVDHYNRFGACFAKTTYDVLGQAIMTSYRDVDQKEVILENHVTGDIL
                     LTLPGQSMRYFANKVEFITFFLQDLEIDTSQLIFNTLATPFLVSFHYPDKSGSDVLVW
                     QEPLYDAIPGNMQLILESDNVRTKKIIIPNKATYERALELTDEKYHDQFVHLGYHYQF
                     KRDNFLRRDALILTNSDQIEQVEAIVEALPDVTFRIAAVTEMSSKLLDMLRYPNVVLY
                     QNASPQKIQELYQLSDIYLDINYSNELLQAVRQAFEHNLLILGFNQTVHNRLYIAPDH
                     LFESSEVAALVETIKLALSDVDQMRQALGRQGQHANYVDLVRYQETMQTVLGG"
     gene            complement(12540..14051)
                     /gene="gtfA"
                     /locus_tag="VVR18_000954"
     CDS             complement(12540..14051)
                     /gene="gtfA"
                     /locus_tag="VVR18_000954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system glycosyltransferase GtfA"
                     /protein_id="HEU6032504.1"
                     /translation="MTIYNINLGIGWASSGVEYAQAYRAGVFRKLNLSSKFIFTDMIL
                     ADNIQHLTANIGFDDNQVIWLYNHFTDIKIAPTSVTVDDVLAYFGGEESHREKNGKVL
                     RVFFFDQDKFVTCYLVDENKDLVQHAEYVFKGNLIRKDYFSYTRYCSEYFAPKDNVAV
                     LYQRTFYNEDGTPVYDILMNQGKEEVYHFKDKIFYGKQAFVRAFMKSLNLNKSDLVIL
                     DRETGIGQVVFEEAQTAHLAVVVHAEHYSENATNEDYILWNNYYDYQFTNADKVDFFI
                     VSTDRQNEVLQEQFAKYTQHQPKIVTIPVGSIDSLTESSQGRKPFSLITASRLAKEKH
                     IDWLVKAVIEARKEIPELTFDIYGSGGEDSLLREIIANHQAEDYIQLKGHAELSQIYS
                     QYEVYLTASTSEGFGLTLMEAIGSGLPLIGFDVPYGNQTFIEDGQNGYLIPSSSDHVE
                     DQIKQAYAAKICQLYQENRLEAMRAYSYQIAEGFLTKEILEKWKKTVEEVLHD"
     gene            complement(14063..16435)
                     /gene="secA2"
                     /locus_tag="VVR18_000955"
     CDS             complement(14063..16435)
                     /gene="secA2"
                     /locus_tag="VVR18_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system translocase SecA2"
                     /protein_id="HEU6032505.1"
                     /translation="MFRRLGQDFQLRKVKKILKQINALKGKMSSLSDQELVAKTVEFR
                     QRLSEGESLDDILVEAFAVVREADKRILGMFPYDVQVMGAIVMHYGNVAEMNTGDGKT
                     LTATMPVYLNAFSGEGVMVVTPNEYLSKRDAEEMGQVYRFLGLTIGVPFTEDPKKEMK
                     AEEKKLIYASDIIYTTNSNLGFDYLNDNLASNEEGKFLRPFNYVIIDEIDDILLDSAQ
                     TPLIIAGSPRVQSNYYAIIDTLVTTLVEGEDYIFKEEKEEVWLTTKGAKSAENFLGID
                     NLYKEEHASFARHLVYAIRAHKLFTKDKDYIIRGNEMVLVDKGTGRLMEMTKLQGGLH
                     QAIEAKEHVKLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRI
                     PTNRPRQRIDYPDNLYITLPEKVYASLEYIKQYHAKGNPLLVFVGSVEMSQLYSSLLF
                     REGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRGTDIKLGKGVAELGGLIVI
                     GTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDM
                     TQPEVLKGRKYRKLVEKAQHASDSAGRSARRQTLEYAESMNIQRDMIYKERNRLIDGS
                     RDLEDVVVDIIERYTEEVAADHYASRELLFHFIVTNISFHVKEVPDYIDVTDKTAVRS
                     FMKQVIDKELSEKKELLNQHDLYEQFLRLSLLKAIDDNWVEQVDYLQQLSMAIGGQSA
                     SQKNPIVEYYQEAYAGFEAMKEQIRADMVRNLLMGLVEVTPKGEIVTHFP"
     gene            complement(16428..16868)
                     /gene="asp3"
                     /locus_tag="VVR18_000956"
     CDS             complement(16428..16868)
                     /gene="asp3"
                     /locus_tag="VVR18_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein Asp3"
                     /protein_id="HEU6032506.1"
                     /translation="MIITQRQSIYWGEVGGTYMYGTTVSYYLDKSVRLYNPLLPSGEI
                     LKTWFSSVNYQAARTQPQLPLLKRKQEYQLSLVFDCQPENGVYTKITFFDRYGDILEK
                     KVEKAKDFIFTYPEDSYTYQVSLLSAGFESLTFYHFSIKEIRSV"
     gene            complement(16865..18400)
                     /gene="asp2"
                     /locus_tag="VVR18_000957"
     CDS             complement(16865..18400)
                     /gene="asp2"
                     /locus_tag="VVR18_000957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein Asp2"
                     /protein_id="HEU6032507.1"
                     /translation="MSKELNILQIGLANWENHYDIPENMSWYYFYPNSSEALREIIEK
                     EDINRFHAVLIEDGQYAKDLFSYVKYFEPYTLFYNQNLQINDREVVDFLKKRCAQAID
                     FLSPQQLINDLSKSLFGGGYGDKLFPPTIQVNPNFTGAISYQGLDYVSLEGEFGQDFA
                     QLAYWAYNIMVQKTLPIELWLEYEKEGNCDFRLVIRKMWSGSVDDFFEEVIVSEKDLE
                     QALFMDSRDGDYFLSISVEARGRGTIKLGNLHQRWSRKQFGKFVLGGNILHDSKRDEI
                     NYFFHPGDFKPPLTVYFAGYRPAEGFEGYFMMKTLGCPFILFSDPRLEGGAFYLGTDE
                     LEGKVKDTITHYLDYLGFDHKDLILSGLSMGTFPALYYGASFEPHAIIVGKPLANLGT
                     IASRGRLDAPGVSNLAFDCLIHHTGGTSSQDMTELDQRFWKIFKQANFSKTTFGLSYM
                     KDEEMDPQAYEQLVSYLCNTGAKILSKGTAGRHNDDTDTNISWFLHFYRMVLETGFGR
                     EKR"
     gene            complement(18384..19964)
                     /gene="asp1"
                     /locus_tag="VVR18_000958"
     CDS             complement(18384..19964)
                     /gene="asp1"
                     /locus_tag="VVR18_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein Asp1"
                     /protein_id="HEU6032508.1"
                     /translation="MYYFIPAWYGSERTWHADITPWYFSHFRLEFDDTFHQIRLFQEQ
                     DIDSRLLVLAYQPHLRYFLYRHGVLETDTYSVFDVMQDFHNLHTQVLSIRDIEWDDDC
                     EFIYSPFTIIVQKNGKKFAKVEHGVEGFISDIQYFGPNGQIHMHHIMDDRGFISSIIF
                     FEDGQAAYQEYLNPKGVWQFRERLKEGGQVEVNPILGYRFKMLTYQNMGDLVAEFFEN
                     YLQTYVKDQDIFMLPSHSHHDQLVLDRLPSTNPKLLSLFIGRNSQDTFRDLDVTFEKS
                     DLILVDREDSLRLLQELYPERMHQCYHLSSFDTRLRLGRSQTKKESIIYFQLDFEQGI
                     DNQALLQVLSFVAENKDTEVIFGAFAASQEQMNEVEGIVESFIQENIQSENLGKAIDY
                     GDAENPLEENQHQDLRLQFVNLNDELDLIKTLEFVRLIVDLNRHPHLYTQIAGISAGI
                     PQINLVETVYVEHLKNGYLLADVTEFSKAAHYYTDRLKEWNESLIYSIDKIKEHTGQQ
                     FLGKLEKWIEEVKNVKGT"
     gene            complement(19974..21191)
                     /gene="secY2"
                     /locus_tag="VVR18_000959"
     CDS             complement(19974..21191)
                     /gene="secY2"
                     /locus_tag="VVR18_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec system protein translocase subunit
                     SecY2"
                     /protein_id="HEU6032509.1"
                     /translation="MTKIYSSIAVKKGLFTLFLLFIYVLGSRITLPFVDLNTKDFLGG
                     STAYLAFSAALTGGNLRSLSIFSVGLSPWMSAMILWQMFSYSKKLGLSSTAIEIQDRR
                     RMYLTLLIAVIQSLAVSLSLPVQSSYSVILVALMNTLLLIAGTFFLVWLSDLNASMGI
                     GGSIVILLSSIVLNIPQDVIETFKLVYIPTGIVVLLVFMTIIFSYLLALMYRARYLVP
                     VNKIGLHNRFKRYSYLEIMLNPAGGMPYMYVMSFLSVPAYLFILLGFIFPNHSGLAAL
                     SKEFMVGKPLWVYVYISVLFLFSIIFAFVTMNGEEIADRMKKSGEYIYGIYPGADTSR
                     FINRLVLRFSVIGGLFNVIMAGGPMLFVLFDEKLLRLAMIPGLFMMFGGMIFTIRDEV
                     KALRLNETYRPLI"
     gene            complement(21248..22153)
                     /locus_tag="VVR18_000960"
     CDS             complement(21248..22153)
                     /locus_tag="VVR18_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001292324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU6032510.1"
                     /translation="MSELISVVVPIYNTGKYLVECVEHILKQTYQNIEIILVDDSSTD
                     NSGEICDAFMMQDNRVRVLHQENKGGAAQAKNMGISVAKGEYITIVDSDDIVKENMIE
                     TLYQQVQEKDADVVIGNYYNYDESDGNFYFYVTGQDFCVEELAIQEIMNRQAGDWKFN
                     SSAFILPTFKLIKKELFNEVHFSNGRRFDDEATMHRFYLLASKIVFINDNLYLYRRRS
                     GSIMRTEFDLSWARDIVEVFSKKISDCILAGLDVSVLRIRFVNLLKDYKQTLEYHQLT
                     DTEEYKDICFRLKLFFDAEQRNGKS"
     gene            complement(22153..23349)
                     /locus_tag="VVR18_000961"
     CDS             complement(22153..23349)
                     /locus_tag="VVR18_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 8 protein"
                     /protein_id="HEU6032511.1"
                     /translation="MRKSIVLAADNAYLIPLETTIKSVLYHNRDVDFYILNSDIAPEW
                     FKLLGRKMEVVNSTIRSVHIDKELFESYKTGPHINYASYFRFFATEVVESDRVLYLDS
                     DIIVTGELATLFEIDLKGYSIGAVDDVYAYEGRKSGFNTGMLLMDVVKWKEHSIVNSL
                     LELAAEQNQVVHLGDQSILNIYFEDNWLALDKTYNYMVGVDIYHLAQECERLDDNPPT
                     IVHYASHDKPWNTYSISRLRELWWVYRDLDWSEIAFQRSDLNYFERSNQSKKQVMLVT
                     WSADIKHLEYLVQRLPDWHFHLAAPCDCSEELTSLSQYTNVTVYQNVLHSRIDWLLDD
                     SIVYLDINTGGEVFNVVTRAQESGKKIFAFDITRKSMDDGLYDGIFSVERPDDLVDRM
                     KNIEIE"
     gene            complement(23358..24578)
                     /locus_tag="VVR18_000962"
     CDS             complement(23358..24578)
                     /locus_tag="VVR18_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase family 8"
                     /protein_id="HEU6032512.1"
                     /translation="MRNTKRAVVFAGDYAYIRQIETAMKSLCRHNSHLKIYLLNQDIP
                     QEWFSQIRIYLQEMGGDLIDCKLIGSQYTMNWSNKLPHINHMTFARYFIPDFVTEDKV
                     LYLDSDLIVTGDLTDLFELDLGENYLAAARSCFGAGVGFNAGVLLINNKKWGSETIRQ
                     KLIDLTEKEHENVEEGDQSILNMLFKDQYSSLEDQYNFQIGYDYGAAAFKHQFIFDIP
                     LEPLPLILHYISQDKPWNQFSVGRLREVWWEYSLMDWSVILNEWFSKSVKYPSKSQIF
                     KLQCVNLTNSWCVEKIDYLAEQLPEVHFHIVAYTNMANELLALTRFPNVTVYPNSLPM
                     LLEQIVIASDLYLDLNHDRKLEDAYEFVLKYKKTMIAFDNTCSENLSEISYEGIYPSS
                     IPKKMVAAIRSYMR"
     gene            complement(24609..27053)
                     /locus_tag="VVR18_000963"
     CDS             complement(24609..27053)
                     /locus_tag="VVR18_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_1767 family glycosyltransferase"
                     /protein_id="HEU6032513.1"
                     /translation="MIKTIVLAGDRNYIRQLETTIKSILYHNRDVKIYILNQDIMPDW
                     FRKPRKIARMLGSEIIDVKLPEQTVFQDWEKQDHISSITYARYFIADYIQEDTVLYLD
                     SDLIVNTSLEKLFSICLEEKSLAAVKDTDGITFNTGVLLINNKKWRQEKLKERLIEQS
                     IVTMKEVEEGRFEHFNGDQTIFNQVLQDDWLELGRAYNLQVGHDIVALYNNWQEHLAF
                     NDKPVVIHFTTYRKPWTTLIANRYRDLWWEFHDLEWSQILQHHMGEFELISPLDKEFS
                     CLTLTNSQDLEGIEELVTALPEVVFHIAAWTDMGDKLKQLAVYNNVRLHPQIVPPVLD
                     KLERSVDLYLDINYSHVVGTILEDMKILEKPIPSFDTTEHGNTGQLVFKKDEVSVMVQ
                     AIKDYRRDGRFLSCYEGSDFHCLTFTNSQELQKIDYLVKNFPMVTFHIAAWTVMGPML
                     QELAKKYKNVKLYPEVKSDQFEELKSQMDVYLDINLHNSTSEVVKEISSLNKPMLAFY
                     TSQNGNHGQHLYSSEHPERLLQAFHALIKGETLGEPEKPIKVIGIDQTLDYVIKNKSS
                     LVRFGDGEVNLMWGLPIPYQNHDLELANQLKHIVGLESDEKLVVCLPDAFDDRFVFTW
                     WATPFWKEHMNVYMDFYKELCKGSWYGSTFISRPYIDYEDKSKAKGQFEKLKSIWENR
                     DILIVEGITSRSGVGNDLFDKVKSVKRIICPSHNAYSVVDNIQEEIMKHAENRLILCM
                     LGPTAKVLSYNLCQMGYQVLDVGHIDSEYEWMKMGAKTKVKFSHKHTAEHNFDQDIEF
                     IDDETYNSQIVARILN"
     gene            complement(27063..28073)
                     /locus_tag="VVR18_000964"
     CDS             complement(27063..28073)
                     /locus_tag="VVR18_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEU6032514.1"
                     /translation="MKLHLTNLYGMAGDSTVILAQNAVQKIASQLGFREVGIYFYNIA
                     SDSPSEMNKRLDGIMASISIGDILVFQSPTWNGFEFDRLLFDKLKDMQVKIICFIHDV
                     VPLMFDSNYYLMKDYMYMYNLSDVLIVPSERMKTRLMEEGLTTKKILVQGMWDHPHDL
                     SLYTPAFKKELFFAGSLERFPDLQNWSQDTPLRVFSNKGEASSSARNLSIEGWKKDEE
                     LLLELSKGGFGLVWGTHQNEGESNQYYTLNISHKVSTYLTAGIPVIVPSSLSTAEFIV
                     DQGLGFVANSLEEVHEIVDKMNLQEYQEMTNRIKTFSYLLKEGYFTKKLLVDAIYHLG
                     VE"
     gene            complement(28102..28980)
                     /locus_tag="VVR18_000965"
     CDS             complement(28102..28980)
                     /locus_tag="VVR18_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000426741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU6032515.1"
                     /translation="MGNELISIVVPIYNVENYLRMCLDSIQNQTYQNFECLLINDGSP
                     DHSSKICEEFVEKDSRFKYFEKANGGLSSARNLGIECSGGGAYITFVDSDDWLEHDAL
                     DRLYGALKKENADISIGRYNSYDETRYVYMTYVTDPDDSLEVIEGKAIMDREGVEEVR
                     NGNWTVAVLKLFKRELLQDLPFPIGKIAEDTYWTWKVLLRASRIVYLNRCVYWYRVGL
                     SDTLSNTWSEKRMYDEIGAREEKIAILASSDYDLTNHILIYKNRLQRVIAKLEEQNMQ
                     FTEIYRRMMEKLSLLP"
     gene            complement(29020..29898)
                     /locus_tag="VVR18_000966"
     CDS             complement(29020..29898)
                     /locus_tag="VVR18_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exopolysaccharide biosynthesis protein"
                     /protein_id="HEU6032516.1"
                     /translation="MKKNHLVGDALILTVSDQIEELDYLLESLSNICFHIAAPVQFSE
                     KIRSLETNYNVRLRTITNEEQLNFLVDTCDFLLDINHFQEVDAIVSKFVQAGKSVFAF
                     DNTVHGNQGQEVFLSSTPDKLVSRVRDYLNEVRVGTNHQEKIIQDGTWNVFKIDDKAH
                     FIVGANVACRNFENFHVSSGKLILNDGVFINNSCSFNCMERIEIGAGTMMGEGVRFYD
                     HDHIYTAEKIEKWQWTTAPIRVGRDCWIGSNVTILKGVTIGDNTIIGAGCLIRNDIPS
                     NSVVYNNGNLCVKRRD"
     gene            complement(29895..31273)
                     /locus_tag="VVR18_000967"
                     /pseudo
     CDS             complement(29895..31273)
                     /locus_tag="VVR18_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854349.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
     gene            complement(31341..>32804)
                     /locus_tag="VVR18_000968"
     CDS             complement(31341..>32804)
                     /locus_tag="VVR18_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015898732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU6032517.1"
                     /translation="SASASASTSASESASTSASASASTSASASASTSASESASTSASA
                     SASTSASVSASTSASASASTSASESASTSASASASTSASASASTSASASASTSASASA
                     STSASASASTSASVSASTSASASASTSASESASTSASASASTSASESASTSASASAST
                     SASASASTSASESASTSASASASTSASASASTSASASASTSASASASTSASASASTSA
                     SALASTSASASASTSASTSASTSASASASTSASASASTSASASASTSASASASTSASE
                     SASTSASVSASTSASASASTSASESASTSASASASTSASESASTSASASASTSASASA
                     STSASASASTSASASASTSASASASTSASASASTSASASASTSASASASTSASASAST
                     SASASASTSASASASTSASESASTSASASASTSASASASESASTSASASTSAGKSRQQ
                     LPNTGTEASKSSVLLGALAAVTGLGLFAKRRKRDDEE"
BASE COUNT         9826 a         7271 c         5670 g        10037 t
ORIGIN      
        1 caagcataaa gcggattcaa agataaagat taaggttcat atactaattt tctttattga
       61 ctttttgtct tctgtattag ggagtttatc attttccaaa aactttatct tcaatttgtt
      121 atctaaaatt tctacaataa aaaagcctac ctttcagtag acttagtttg tttctattct
      181 aatcggcact ctgccaaaat tctgttctgc tatacttgga tttcccaatt ggtaaatctg
      241 gtctgccttt tgagtcatga catcccaagg ttccttgcca attctgctga ctagactgac
      301 ctgccctttc agatatttaa gatgttgcct gcctttttcg gtaaagccaa ggacatgaat
      361 ggcttctggc aagacatttt ccctagcctg caccaaaata taggtcaata ggcgtctgac
      421 acgcgccttg gtgtaacgtt tagtagtcac taactcgacc aattcttcca cagactgggc
      481 tgttttaata gcttctttaa tgcgcacagc catttcttga ttgacctgat agatggtggt
      541 taggtcggga tttgacaaga tttgatagcg gagcaaggga aaatagtctt cccagatcac
      601 cttactggcc tgctcaaata gggcaacaga aggcataaaa cgttctaaga aatcttggtc
      661 cttctgatgt tgacggaggg ctgtcgccga ggcaaagtcc acatctttat tcacagaatg
      721 gtaacctgcc ccctgacgct gaatcggatg cagcttgata tttcgtcctg caaccgcctt
      781 tgcataggcc agagcaagaa catgattggg ggtattacct gaaaaatcaa gaccagcaaa
      841 ttccttccac atagcttggg ttttctgggg ataggaaagg gaatcaggca gattttccac
      901 aaatttctcc atctcagcac ctttctctgt gtataagtca gcgattttct gataatctcg
      961 aacttcctct gtcccaaaaa ctagactatc aatgcccaag cgatccaaga tatccacagc
     1021 tccttgacca aagaaatcag ctgcctgaac actgactaaa aagggcaatt ccactaccaa
     1081 gtctgcgcca ttttccagcg ccatctgggc ccttgtccac ttatccacaa tagcaggctc
     1141 tccacgctgc atgaaattcc ctgacatggc aacaattttc agtccctctg cctgatccag
     1201 caggtattta tggccattat gaaaaggatt gaactccgcg ataatacctg tgatggtcat
     1261 gctaatctcc tacttctgcg ccacaaaaaa ccaacgggtg ctagtttctg ttggctcctt
     1321 atcctcaaag tctgcataga gtttgaagga cttgaatcca gcctgttcca gtaagatatc
     1381 ataggtcaag atctcatagg tcctctcctc atgtacttca tcgtggcgac taaaggaacc
     1441 gtcagcctcc ttgataaaga aagtcagctc atgcacgatg gagtgaggag cttcgtcctc
     1501 atatgtatcc caaagcatgg caaaatcttc cgcattttca tggtaggaat agccagggaa
     1561 tacttcatct gtctggtagg tcgagtgcac gtcaaagatg aaaactccct cttcattcag
     1621 cgcattgtac acgtccttaa agacgtcccc tacttccacc tcatcctgca tatagcagat
     1681 agagtccgaa taacacgtga caaaatcgta tttccctgcc ttggacaaat tcagcatatt
     1741 accttctata aaagcaatct tttgcttggc tgaagttgct ctcttctccg caatcttcaa
     1801 catatccgca ctcaagtcaa gtccagtcac atcaaaacca gcctgagata agcgcactga
     1861 ttgaattcct gtcccacaag ccagttccaa gagtttcttt ttctccttgg tcttaggcaa
     1921 atgacgcaga gaaaaatttg tccatttgtc gtataaacta tcgtccatga ccgcatcata
     1981 gaccgccgca aaggtttcat aagtcgccat aatcatgata ctaagagctc catggtaaac
     2041 accactagcc ctttaccttt ctatcaattt ttctaaaata agcaaagaaa cccagttgac
     2101 tacaactgag ttcatcttct aagcaagagc ttctgaaata tctactgaat tcgcctcatg
     2161 ccatagcttc tctaggttat aatgggcacg catttcttct gaaaagatat gcacgacaac
     2221 agcaccgagg tccagtaaga cccagcctcc agctgcatcg ccttcgacat ggctaccttt
     2281 aaagcccgct tgagctactt tttcacggat attagctgcg atagcgtcca actgacggct
     2341 attcattgag ctagtgatga caaagtagtc cgtcacacta gtcaaatctt gtacatcaag
     2401 tgcgaggata tcctccgcac gtttctcatc agccgctttc acgactagtt ctagtaattc
     2461 tttttcgttc atttaatcct ctttttagaa aatatgtttg taatctagga catctgcaaa
     2521 gtgctcctcc caaatgtcct cataaaattc attaatcgtt tctgctggaa tgtcatcccc
     2581 atcaaaggtt gtgacagcac cttctggaac aataagctga tagccatatt caaaggcaac
     2641 cttgacagag gtatccacac aatattctgt ctgcatacca cataaaacta atttttcaat
     2701 cccctgctta tccaagtatt cttttaagcc agtttctttg aaaatactgt tatacttctt
     2761 ctgaaagacc ttttcagcag gttttcgatt taaaagcgca gataactgcc aatcttctga
     2821 tgtttgagct tcagagttct caatatgttg aacatagata atttcaatat tcttgcttct
     2881 agcctggttt tgtaaataag aaatttttcc caatagactt tttgtctgga atccagtttc
     2941 tactaaaaca ttctgaacat caatgattat aaaagccgtc ttcatttagt tctctttcaa
     3001 atagtgcaca aaggcgttat aggtttcaag ggtttgggga tagatgggga atccctgatg
     3061 agctagatac tccacggtac gagctgtttc gtaggccacc gccttattga gcgatagact
     3121 tgcaatctca cgcgccacat ctactccagg aaaggctcga ttgtgctcga tatagtctgc
     3181 gacgtagatg accttatcta ggtctgtcat ttgaccagca ccgactgtat ggacttcaat
     3241 ggctcgcaga atttcagaat catgcaaatc caaatcttcc tgaattttgt aaattccgac
     3301 cataccatgc cagacattat taccccagtt tttgaggtcg aaatctagct gataacggtc
     3361 aatcaaggct agaaattcct gatctgacaa ctttttagca tagtcatgaa gaagacctgc
     3421 tagacttgct ttctcaacat ctacaccaaa gcgctgagct aattccatag cggcacgctc
     3481 cacacctaga caatgggtta gacgtttctc aggtagaagc tctgccattt tttccaacaa
     3541 aacctcacgg gagcagttga tatagtcttg ataggacatc agtagagccc ctccttctcg
     3601 atgtagtcta gcactggctg aggtaggaga aagttgggtt tccgaccttg ggcaatgaag
     3661 tcccgcacca tgctggacga gatatccatg agcggtacgt ccacccagat aactggatag
     3721 gaagtccctg ccttgtagcg tggacgctga acccccacaa actgaaccat gtcaaccagt
     3781 tcatcaattc ggtaccactt aggcagatag tcaaccatgt cggcgccgat gataaagtaa
     3841 taatccgtat ctggattctt ctctgtcaaa atcttcatgg tatcgtaggt gtaggaaata
     3901 cccttgcgct ccaactcaat ggtttcaatg actaggccgt caatcccctc aattgccaac
     3961 tcaagcatct tgagacgatg gtgttcaggg atggtttcct ttttatcaac gtgaggaggt
     4021 tggtattcag gcatgagaag aacttgatcc agtcccaact gttgccgtac ttgatccgca
     4081 acaatgagat gggcattgtg aacagggtta aaattccccc ctaaaatccc aacttgtttg
     4141 cgttttttct ccttgatttc tggctccaac tctaccttgg taaagggagt caatagttcg
     4201 attgtcatag gctagtcccc tttatttctc tataaaaaca gttatttgga gtttcggtct
     4261 tagatttctt tgactttctt agaaatcttg cgattttctt tcttgctaga ttgtttaaac
     4321 aaaatcaaga tgcgtcctat tttttggact gtatccacac cgatttcttc ttccaaaatt
     4381 tcagctactt cgtggatgtt ttcatctgtg ttttgtaaga gagtaacctt gattaattca
     4441 cgcgcatcaa gagcttgacg gacgctggtt ttgatttggt cgttgagtcc atttttcccg
     4501 atttggatga taggtttgag ggtgtgtgcc tggctgttga ggaaggcacg ttgttttgat
     4561 gttaatgaca taattttctt ccttgttttt tgatagttat tttaggtggt gagggacggt
     4621 cggaactaat tttccaaaga tttcatcttt gaaaaatgga tttcctgacc tcacaattga
     4681 gccttggtct caattgtgcc ccttgccaat ctacagattg gcaatcacac cacggcaata
     4741 actatcgcta tatgagctca ctttgttcgc tcagcgattt tgttttaaat aattgctttt
     4801 cgtgtgacga cggcgacgcc ttctggtgcc cagacggcga cttttgctat gcctgttaca
     4861 cgaatccagc ctaggcctga gatgactagg tctgtcttat ctttaatggt aaagacatgc
     4921 tggactagcc ttgggaaatc ttctttttcc ttgctatttg gtggtgtcag aagagttccc
     4981 aggtgcttat cgtagaaagc actagctcct tcaagcttgc tacgatggag tttgagttca
     5041 ttatcaaaga aagcagtaaa tccttgcttt tctcctgcta taaagtcaaa gcgtcccaaa
     5101 ccacctaaaa atagggtttg ctcaggatta agctgatagg tcttaggctt gatttccttt
     5161 ttaggactga catacttgag gtttttggcc gtcaagtagt gagccatctg gtggcggtgg
     5221 ataattcccg gcgtatcgta aatataagat ccgtcgtcaa gcggaatctc tattttgtcc
     5281 aaggttgtcc ctggaaagcg tgaagtagtg atgacattct gatcacccgt gatttcttgg
     5341 ataatagcat tgattagagt tgattttcca acgttggtca caccgaccac atagacatcg
     5401 cggcccttac ggtagtgttc aatcttatca atgacttcct taatggcatg tttattttgt
     5461 gctgaagtta ggaccacatc gactggacga agaccttctt catgggcacg tttcatgagc
     5521 cactggctaa tcttaccaga cttaactgac ttaggaagga tatctttttt atttcctacc
     5581 aagaggacat cattgcccga gacgaaacgt ggtaaacctg ggatgacaga tccattaaaa
     5641 tcaaagatat caatgacatt gaccactaaa gcatcactgt ctcccacctc gtgcaagagc
     5701 ttgaggaaat catcgttcgt caactggaca tctgtgattt cattgtagtg gcggagacgg
     5761 aaacagcgtt ggcaatagac ttcgccagtc tccaaacctt tttcaagtgc cgactggggg
     5821 gtaaaaccaa gaccagcctt atctgtcgtc tgaatggttg ctccacaacc aatacagaga
     5881 atttcttcca tagttaaatt ccttttttat atgtaatcgg tccgtacttt tcagtgattt
     5941 ttctcataac acgacgctca cgagttcggt taatctgcgt tttgattgag tcatgttgga
     6001 ccaagggttt gactaaaatt gaccgaatcc ctgcacggtg ggctgctcgt atatctgtca
     6061 tgagctggtc accaaccatg accacttcct ttttgtcata gtggaattcc ttcatagcac
     6121 ggtcaatacc aaatgtgaag ggcttcaagg cccagtaaac gtaatcaata ccaaatttct
     6181 caactgctcg ttgaacgcgt tttttggtgt tatttgacac tacgataatg ccaatacccg
     6241 cgtcccgaag gtcatgtagc cattgcttca tctctggcgt tccatcaggg ttgttccaag
     6301 caatgagggt attatccaaa tcgaccaaaa cagccttgat tccctgcgcc tgcaggcttg
     6361 ggactgtcag atcatagact gcttccacag caaaatctgg tatataattt tcaatcgcca
     6421 ttctggctcc ttttcttaac tttttttcgc aattttcctt agtaacaagg ataaaacaat
     6481 ccacaaacct gcactagcca aactaatata gagccaagca tggggctcat ctgttaaagg
     6541 taagggaaca ttcattccga aaaagcctgt cacgactgcc aaaacagcta gcaagactga
     6601 aataatagtc aaggttgtca aattgtcatt caaattattg tttagaatat tgttgtaaga
     6661 ggctgaaagc tgctgtaaaa tctgagagat taggtctgtc atggatacca gctgatgagc
     6721 ctcaatcatg gcatcatcaa actgttctct ctcaatctca tcaaaactac gatacaaggc
     6781 atgaccttga atatgctcta acaaaatccg attttgtttg gcagctgccg tcagataaac
     6841 cataccagtc tccaaatcag acagggcaaa gaggtttttc ttggtagttc gctggcgcaa
     6901 gaggtcattg acctcatccc tactcttgtc catctgctca atgacaggat agtaggcatt
     6961 gctgataatt tccagactgg caaagagaaa cttataaatc gaaagcgtgt catggttttc
     7021 cagataacga gtcatctgtt caatgacata ggcgttcttg gtattactaa tggtaatcag
     7081 gcgacgatgc tcgacaataa aggtcatggg aaaagtctca tagtaggcct tgtccttttt
     7141 tacgtctagg acattataga taaaggtaac cgtcccactt tcacggtggt agtccatgtg
     7201 ggcgcgctcg tttctatcca gtgcgtattc aatggtttcc ttgtccaaac cgtaaatttc
     7261 agaaaggtct tctagtttat tcaactttcc taggtctagg tctatccagg tacaaccatt
     7321 gcccaactgc ttttctaaaa ccatcttttc tccttattaa actccctcta ttgtaccaca
     7381 aattacttaa aataacaggt ctagtctgtg cgtgagaaat tgctaacaac tgtgatattt
     7441 cggttaggga caaagtgaag gacttgctcc tcgctacgaa gctgtgtcgt acgaattccc
     7501 acactgacaa ccttacccga tacagtaatc ggtccatttg tcagaacgac ctcatctccc
     7561 acatccagtt gacgttcaaa gaggatgaaa aagccattga tgacatcaga tagaaagcct
     7621 tgggctccca taccaatcgc taccccagca ataccagctc cagccagcaa actagaaact
     7681 ggcaaaccta aaatcgacaa aatgcagtag agtaaaaaga aatatagcgt ataattaaac
     7741 acattttcta gtaaacgtga gatggttttt tggcgtccaa catcatgacg agacattttt
     7801 agagaaggtt tgacaattct ctgcaccatg gtatgaagca tttttttagc aatataaaat
     7861 acaatcaaaa gcagtaaaag agaaatgacc ttggttagaa tattctcgat aatggttgtc
     7921 acatctagct tttcaatata agcctgaata aatttttgca tataaaactc ctttatttca
     7981 ttataccata ttttcatcag tctcattctc cataaatatt caaaaaatag acagaaaatt
     8041 cttgattttg tctatcattt atactataat cataatcact acacaaaaag gagattatta
     8101 tgaaaagaat cattcatgct tggaataaag caagccttgt caagcgtatc ttgattggta
     8161 tgctttatgg ggaatcctag gactgaccct tcctaatctc tcagggattg ggctactcgg
     8221 ggatttattc gttggaggtc taaaagctgt tgctcctatc ctagtctttg ccctcgttgc
     8281 caatgccctt tcccaacatc aaaagggaca agatagcaat atgaaaactg ttgttttctt
     8341 gtatatccta tgatagggac tttcgccgct gctcttgtag ctgtactagc aagtttcatc
     8401 gtccctattg aaattaccct aaatagtgcc aatactgaaa ttgcaccacc agatgggatt
     8461 gggcaggtcc tcagcaacct cttgctcaaa ctggttgaca gcccagtcaa cgccctgctt
     8521 actgctaact atattggaat cttatcttgg gcagtcattt ttggaatcgc tatgagagaa
     8581 gccagtaaaa ccagtaaaaa tagtaaagaa ttgctaaaaa ctatcgctga cgtgacttct
     8641 aaaattgtcg aatggatcat caatctggct ccatttggaa tccttggtct tgtttttaaa
     8701 accatttctg acaagggagt cggaagcctt gccaactacg gtattttatt ggttccatta
     8761 gtaacgacta tgctttttgt tgcccctgtg gtcaaccctt tgattacctt cttctttatg
     8821 agacgcaatc cttactctct agtttggaac tgcctccgtg tcagcggtgt gacagccttt
     8881 ttcactcgta gttctgcgac taacattcct gtcaacatga aactctgcca tgaccttgga
     8941 ctcaacccag atacctattc tgtttctatc ccactcggtt ctactatcaa tatggctgga
     9001 gtagcgatta ccattaacgt tttgaccctt gttacagtta acactcttgg aattcctgtt
     9061 gactttgcca cagcctttgt cctcagtgtg gtagcagcta tctcagcctg tggtgcttca
     9121 ggtattgccg gaggttccct ccttcttatc ccagttgctt gtagcctttt cggtatttct
     9181 aacgatattg ccatacaagt tgttggggtt ggttttgtga ttggtgtcat ccaagactca
     9241 tgtgaaacag cccttaactc ttctacagat gtcctcttta ccgccgttgc cgaatacgca
     9301 gcaacccgta aaaaataact catcaaggca agcctgctca tgtcttgtct tttacgcttt
     9361 tattctaact tattaggaaa ttcttatgtc tattagccaa cgtacgacca agctcatctt
     9421 agctacctgt cttgcctgcc tgcttgctta ttttctcaat ctttcgtcag cagtttcagc
     9481 tggaattatc gctctcttga gcctatctga tacgcgtaga agtactttaa aactggctcg
     9541 caatcgtctt ttttctatgc ttctagctct ggctatcggt gttctagctt ttcacttgag
     9601 cggatttcat atctggagtc tcggcctcta tctggccttc tacgttcctt tagcctacaa
     9661 gatgggctgg gaaattggca tcacaccaag cacggttttg gttagtcatc tcttggttca
     9721 agagtcaacc tctccagacc ttctagtcaa tgaattcctt ctctttgcta ttggtacagg
     9781 atttgccttg cttgttaatc tctatatgcc ttcacgagaa gaggaaatcc agcactacca
     9841 cacgctggtg gaagaaaagt taaaagatat cctccagcgc ttcaaatact atttatccag
     9901 aggagacgga cgcaaccgag cacagctggt agcagaatta gacacgcttt tgaaagaagc
     9961 cctcagactg gtctatttgg atcactctga ccacctcttt caccagaccg actaccatat
    10021 ccactacttt gagatgagac aacgacaaag tcgtatcctg agaaacatgg cccaacagat
    10081 taacacttgt caccttgccg ccagtgaaag cctgatttta gcgcagctct tttcaaaaat
    10141 tgctggtcaa ctgagccaga ccaatcctgc ctctgatttg ctagatgaaa ttgaacgtta
    10201 tctggaagtc ttccggaacc gcagtctgcc caagacaaga gaagaatttg aaacccgcgc
    10261 cacccttctc caactcctac gtgaagccaa aaccttcatc caagtaaaag ttgactttta
    10321 tcaaaaatat ggacagtaat actcttcaaa ctacgtcagc ttcaccttgc tgtatatatg
    10381 ttactgactt cgtcagttct atccacaacc tcaaaacagt gttttgagct gacttcgtca
    10441 gttctatcca caacctcaaa acagtgtttt gaactgactt cgtcagttct atccacaacc
    10501 tcaaaacagt gttttgagct gacttcgtca gttctatcca caacctcaaa accgtgtttt
    10561 gagctgactt cgtcagttct atctacaact tcaaaacggt gttttgagct gacttcgtca
    10621 gttctatcta caacctcaaa acggtgtttt gagctgactt cgtcagttct atccacaacc
    10681 tcaaaacagt gttttgagca gcctgcggct agcttcctag tttgctcttt gattttcatt
    10741 gagtataaaa aagaaaactt cagaccaatc cacaaaaggt gaatatctga agttttcttt
    10801 tatttataag taatcaccat aaaggttaat agtagaacaa ataaagccaa actcaccaat
    10861 aaagtgagca ccttgaccaa ggtgttgctc tgccagtagc ttggtttacc aatattacta
    10921 gtggcatcca tggaaaatag ttgattttga cggggttgta tagttaccaa tacaatcaaa
    10981 gcaagagata ggataatagc taaaacaatt agtatgtcaa tcatagatct acctcaaaat
    11041 tcccagcaaa gtaaagagca aaccaatcag aatcatcaaa cccagtaaaa gtgaaaaagt
    11101 cttactaatc ttttcccctc gggtttcttt ttccttcttg atgggttttt gtttcaactc
    11161 ttccatgcgg ccttcaacgt ctttgtaaaa taaatcttcc tctgacatgt tagcctccta
    11221 aaacagtttg catggtttcc tgatatctca ccaagtcaac ataatttgca tgttggcctt
    11281 gtctgccaag tgcctgacgc atttgatcaa catctgaaag ggccaattta atggtctcaa
    11341 ccaaagcagc aacttcacta ctttcaaata gatggtctgg agcgatataa agtctattgt
    11401 gaaccgtttg attaaatcca agaatcaaga gattgtgctc aaaggcctga cgaactgcct
    11461 gcaataactc attgctatag ttgatatcca agtaaatatc cgacagttga tacaactcct
    11521 gaatcttctg tggactagca ttctggtaaa gaaccacatt aggatagcga agcatgtcta
    11581 agagcttaga agacatctct gtcaccgctg cgatacggaa ggtaacatca ggcaaggctt
    11641 ctacgattgc ttctacttgc tcaatctgat ctgaattggt caagattaag gcgtctcgtc
    11701 ttaggaaatt atcacgtttg aactggtaat gataacccaa gtgcacaaac tgatcatggt
    11761 atttctcgtc agttaactct aaagcgcgct cataagtcgc cttatttgga ataatgatct
    11821 tcttagtacg cacattatca ctttccaaaa tcaactgcat attacctgga atggcatcat
    11881 aaagaggttc ctgccatacc aagacatccg agccagattt atctggataa tgaaaggaaa
    11941 ccaagaaagg agtcgctaga gtattaaaga taagctgact ggtgtctatt tccaaatctt
    12001 gcaaaaagaa ggtgataaat tcaactttat ttgcaaagta acgcatggac tgaccaggca
    12061 aagtcaataa gatatcaccc gtcacatggt tttccaaaat aacttccttt tgatctacgt
    12121 cccgatagga agtcataata gcttgcccca aaacatcata agtggtttta gcaaagcaag
    12181 caccaaagcg attgtagtgg tcaacctgac gtactcgacc ttctaggtct ttccagtcta
    12241 cctgtttaac caagcgagcc tgcattccat cagcataatg aatgacagcc ctctcctgcg
    12301 tcacatcttc aatacaagca gactgattat ctcctaaaat ttcccaaaaa tctgaaacgg
    12361 gaacttggtt aaaatagaga ggttttccat cctcgtaacc tagataatag gtaaaaggag
    12421 aaagcagacc atcaggcaga aaaccatctg catcgatgac cactccaagt tgagaaagac
    12481 cagtagcgac tagactttca tgtaaatctc gactttcttg actgtaacta tcataaagtt
    12541 caatcatgga gcacctcctc tactgttttc ttccactttt ctaaaatttc tttggtcaag
    12601 aagccttctg caatttggta agaataggca cgcatagctt ccaaacgatt ttcttgatac
    12661 aattgacaaa tcttagcggc ataagcttgc ttgatttggt cttctacatg gtcagatgaa
    12721 cttggaatca aataaccatt ttgcccatcc tctataaagg tctgattacc ataaggtaca
    12781 tcaaaaccaa ttagaggtag acctgaacca atagcttcca tcaaggtcag accaaatcct
    12841 tcgctggtag aagccgttaa gtagacctca tactggctat aaatctgcga aagttccgca
    12901 tgccccttga gttggatata gtcctctgcc tgatgatttg caataatttc tctaagcaga
    12961 gaatcttctc ctccactacc ataaatatca aaggttaatt cagggatttc cttacgagcc
    13021 tcaatcacag ccttaaccaa ccaatcaatg tgtttttctt tggccagacg tgaagcggta
    13081 attaaagaaa atggcttacg tccctgactt gactccgtca aggaatcaat actacctaca
    13141 ggaatggtaa caatctttgg ctgatgctga gtatatttgg caaattgctc ttgtagaact
    13201 tcattttgtc tatcagtaga cacgataaag aagtcaacct tatctgcatt ggtaaactga
    13261 tagtcataat agttattcca aaggatgtag tcctcatttg tagcattttc actataatgc
    13321 tccgcatgaa caactaccgc taaatgtgct gtctgtgctt cctcaaacac aacctgacca
    13381 atgcctgtct ccctatcgag aatgaccaaa tcagacttat tcaaattcaa agatttcata
    13441 aaggcacgca caaaagcttg ctttccatag aaaatcttat ccttgaaatg ataaacttct
    13501 tccttccctt gattcatcaa gatatcatag actggagtcc cgtcttcatt gtaaaaagtt
    13561 cgttggtata agactgcaac attgtccttg ggagcaaaat actcgctaca ataacgcgta
    13621 taagaaaagt aatccttccg aatcaggttt cccttaaaaa catactcggc atgttgaacc
    13681 aagtccttgt tctcatcaac caaataacag gttacaaact tatcttggtc aaaaaagaag
    13741 acacgtaaaa ccttgccatt tttttctctg tgactttctt caccaccaaa gtaagccaag
    13801 acatcatcca ctgtcacgct agtaggcgca attttgatat ctgtgaaatg attataaagc
    13861 cagataacct gattatcatc aaaaccaata ttggctgtta agtgctgaat attatcggct
    13921 aaaatcatat ctgtaaagat aaacttagag gacagattta atttccgaaa aacaccagca
    13981 cgataggctt gagcgtattc aacaccgcta ctagcccaac caattcctaa atttatattg
    14041 taaattgtca tattttctcc tcttatggaa aatgagtcac gatttcacct tttggagtga
    14101 cctcaaccag ccccatcagg agattacgca ccatatccgc acggatttgt tctttcatag
    14161 cttcaaagcc cgcgtaggct tcttgatagt actctacgat tggatttttc tgactagcag
    14221 attgaccacc gatagccatg gatagctgtt gtagatagtc tacctgctct acccagttgt
    14281 catcaatggc tttaagcagt gaaagtcgta aaaactgttc atataagtca tgttgattaa
    14341 gtaattcttt cttttcagaa agttctttat caatcacctg cttcataaaa ctacgaactg
    14401 cagttttgtc agttacatct atataatctg gaacctcttt aacatgaaaa ctaatattgg
    14461 tcacaataaa gtgaaacagt aattcacgac tagcatagtg atcagccgct acctcttctg
    14521 tatatctctc aatgatatcc acaacaacat cctctaagtc acgagaacca tctattagac
    14581 gattacgctc cttgtaaatc atatcccgtt gaatattcat actttcagca tattctagag
    14641 tctgacgacg tgccgaacgg ccagcactat cactggcatg ctgagccttt tcgactagtt
    14701 tccggtattt acgacctttc aatacttccg gttgagtcat atcttgaacc tgatagtctt
    14761 tgtacttttt atgcacccaa gatggaccaa atttcttgat aacatcatcc tctaaggata
    14821 caaaaaattt actcatacca ggatctccct gacgaccaga acggccacga atttgtaggt
    14881 cgatccgctg actttccatc cgctcagtcc caataacaat caagccccca agctctgcga
    14941 ctcctttacc aagcttgata tccgtaccac gtcctgccat agaggtagcc actgtcacag
    15001 cccccatctg acctgactcg gagataatct gagcctcacg cgccgcatta ttagcattta
    15061 ggacattatg ggcaatccct tcacgaaaca agagagacga atagagttga gacatttcaa
    15121 ctgagcctac aaaaacgagt aagggatttc ccttagcatg gtattgcttg atgtactcca
    15181 aggatgcata cactttttca ggtaaagtga tatatagatt atctggatag tcaatccgtt
    15241 gtctcggacg attggttgga atgcgtacta cagacatatt gtaagtttca ataaactctt
    15301 tttccgcgac cttacctgtc cctgtcatac cagatatctt attaaacatc ttaaaaagac
    15361 tctgataggt gatcgaggcc atagcccgcg tctcaggaga taatttgaca tgttccttgg
    15421 cttcaatagc ctgatggaga cctccttgaa gtttagtcat ttccattaga cgccctgttc
    15481 ccttatcaac cagtaccatc tcatttccac gaatgatata gtccttatct ttagtaaaga
    15541 gcttatgagc tcgaatcgca taaaccaaat gacgagcaaa agacgcatgc tcttccttgt
    15601 ataaattatc aatccctagg aaattctcag cagacttggc ccccttagta gtgagccaaa
    15661 cctcctcttt ctcctcttta aagatataat cctctccttc gaccaaggtt gttacaagtg
    15721 tatcaatgat cgcatagtaa ttagactgaa cacgaggaga acccgcaata atcagaggag
    15781 tttgtgcact atcaagcaag atatcatcaa tttcatcaat aatcacatag ttaaacggtc
    15841 gtaaaaactt accttcttca ttcgaggcta ggttatcatt tagataatca aaacctaaat
    15901 tactattggt tgtgtagatg atatccgaag catagataag cttcttttct tcagctttca
    15961 tttccttctt tggatcttcc gtaaatggta caccaatggt caatcctaga aaacgataaa
    16021 cttggcccat ttcctcggca tcacgctttg ataaatactc attaggagtc acaaccatca
    16081 ctccttctcc tgaaaaagcg ttcaaataga caggcatggt agctgtcaag gtcttaccgt
    16141 cccccgtatt catctcagca acatttccat agtgcatgac aatagctccc atgacttgaa
    16201 catcataggg gaacatccct aaaatccgct tatctgcttc acgcaccaca gcaaaagctt
    16261 caaccaaaat atcgtctaga ctttctccct cggaaagacg ctgacgaaac tctactgttt
    16321 tagctactaa ttcttgatcc gaaagagagg acatcttgcc tttcagggca ttaatctgct
    16381 ttaaaatctt tttcactttc ctaagctgga aatcttgacc taaacgtcta aacacttctg
    16441 atctccttga tagaaaaatg ataaaaagtt aaggactcaa atccagcact taaaagagaa
    16501 acttgataag tataactatc ttctggataa gtaaatatga aatctttcgc tttttctacc
    16561 tttttttcta aaatatcacc atagcggtca aaaaaagtta tcttggtata aactccattt
    16621 tcaggctgac aatcaaaaac cagtgatagt tgatactcct gctttctttt taataaggga
    16681 agctgaggtt gggttcgtgc agcctggtaa ttgacactag aaaaccaagt ctttagaatc
    16741 tcaccagatg gcaatagagg attatacaga cgaacacttt tgtcaaggta ataagataca
    16801 gttgttccat acatataagt cccaccaact tctccccaat aaatagactg tctctgtgta
    16861 ataatcatct tttctccctt ccaaaaccag tctctaagac cattctataa aagtgcaaaa
    16921 accaagaaat attggtatct gtatcatcat tgtgtcgtcc agcagttcct ttagataaaa
    16981 tcttcgcacc tgtattacac agataagaca ctaattgttc ataggcttgt ggatccattt
    17041 cttcatcttt catataggat aaaccaaagg ttgtctttga aaaatttgct tgtttaaaaa
    17101 ttttccaaaa acgctgatcc aactccgtca tatcttgaga acttgtccca cctgtatgat
    17161 gaattaaaca atcaaaagct aagttagaga cacccggtgc gtccaaacgt ccacgactag
    17221 ctatagttcc taaattagcc aagggcttac caactatgat ggcatggggt tcaaaagaag
    17281 caccataata gagagccgga aacgttccca tagaaagacc tgataaaatc aaatccttat
    17341 gatcaaagcc taaataatca agatagtgag tgatcgtatc ctttactttt ccctctagct
    17401 catccgttcc gagataaaaa gctcccccct ctaaacgtgg atcagaaaat aaaatgaagg
    17461 gacatccaag agttttcatc ataaagtaac cctcgaatcc ttctgcaggt cgataacctg
    17521 caaaatagac agtcaaaggc ggtttaaaat cacctggatg gaagaaatag tttatttcat
    17581 cacgcttgga atcatgtagg atatttccac caagtacaaa cttaccaaat tgttttcgac
    17641 tccatcgttg gtgaagatta cctagtttga tagttccacg acctcttgct tcaacagata
    17701 tcgagagaaa gtagtctccg tctcgactat ccataaaaag tgcttgctcc aagtcttttt
    17761 cagatactat tacttcttca aagaaatcat caacagaccc actccacatt ttacggatta
    17821 ctaaacgaaa gtcacaattg ccttccttct catattcaag ccacaactca atagggagtg
    17881 ttttttgcac cataatatta taagcccaat aggcaagctg ggcaaaatct tgcccaaact
    17941 caccttccaa actgacataa tccaatcctt gataagaaat agctcctgta aaatttggat
    18001 tgacttgtat cgtcggagga aagagtttat caccataccc accgccaaaa agagatttac
    18061 ttaaatcatt gattagttgt tggggactta aaaaatcaat tgcttgtgca catcgttttt
    18121 ttagaaaatc cacaacctct ctatcattta tttgtagatt ctggttataa aataaagtat
    18181 aaggttcaaa atattttaca taggaaaata agtctttagc atactgacca tcttctatta
    18241 aaactgcatg aaaacggtta atatcctctt tttcaattat ttcacgaaga gcttctgatg
    18301 agtttgggta aaaataatac caactcatat tttcaggtat gtcatagtga ttttcccaat
    18361 tggcaagtcc tatctgtaaa atattaagtt cctttgacat ttttaacctc ctctatccat
    18421 ttctctaatt ttccaagaaa ttgttgtcct gtgtgctcct taatcttatc aattgaatat
    18481 atcaaggact cattccactc cttcaaccta tctgtgtaat aatgtgcagc cttagaaaat
    18541 tctgtaacat ctgctaacaa ataaccattt tttaaatgtt caacatagac ggtttcaact
    18601 aggttgattt gaggaattcc tgcactaatc ccagcaatct gtgtgtagag atgaggatgt
    18661 ctatttaaat ccacaatcaa acggacaaat tctagtgttt ttatcaaatc taactcatca
    18721 ttcaagttaa caaactgtaa gcgtaagtcc tggtgttgat tttcttccag aggattttct
    18781 gcatcaccat aatcaatcgc ctttcccaga ttttcggatt gaatgttttc ttggatgaaa
    18841 gactcaacaa tcccttcaac ctcattcatt tgctcctgac tagcagcaaa ggctccaaaa
    18901 atcacctcag tatccttatt ttcagcgaca aaggacaaga cttgaagcag agcttgatta
    18961 tcaatcccct gctcaaaatc cagttgaaaa taaatgatgg attctttctt agtttggctt
    19021 cgtcccaatc gtaatcgggt gtcaaaagat gataaatgat aacattgatg cattcgttca
    19081 ggatacaact cctgcaacaa tcgtaaacta tcctctctat ccaccaaaat caaatccgat
    19141 ttttcaaaag ttacatctaa atccctaaag gtatcttgag aattacgtcc aatgaacaga
    19201 ctcaacagtt taggattagt actaggtaaa cgatctagta ccaactggtc atgatgagaa
    19261 tgagaaggaa gcataaaaat atcctgatcc ttcacatacg tttgcagata attctcaaaa
    19321 aattctgcca ccaaatctcc catattttga taggtaagca ttttaaagcg ataacccaaa
    19381 attggattga cttctacctg tcctccttct tttaaacgct ctctaaattg ccaaactccc
    19441 ttaggattca aatattcttg ataggctgct tgcccatctt caaaaaaaat aatactcgat
    19501 ataaaccctc gatcatccat gatatggtgc atatgtattt gaccattcgg tccaaaatac
    19561 tgtatatcac tgatgaaacc ttcaactcca tgttcaacct tagcaaattt cttcccattt
    19621 ttttgaacga taatcgtaaa gggactataa ataaattcac agtcatcatc ccactcaata
    19681 tctctaatgc ttaaaacttg ggtatggaga ttatgaaaat cttgcataac atcaaaaacg
    19741 gaataagtat ccgtttctaa cacaccatgt ctatataaaa aataacgtag atgaggctgg
    19801 taagctaata ctaatagacg agaatctata tcttgctctt gaaagagccg aatctggtga
    19861 aaggtatcat caaactctag acgaaaatga gaaaaatacc atggagtgat atctgcatgc
    19921 catgttcttt ctgacccata ccaagctgga ataaaataat acataaaagt ctcctaaatc
    19981 aaaggtctat aggtctcatt tagccttaaa gccttgacct cgtctctaat cgtaaaaatc
    20041 atgcccccga acatcataaa taagcctgga atcattgcca atcgtaataa cttttcatca
    20101 aacaaaacaa aaagcatggg accacctgcc ataatcacat taaagagacc acctatgact
    20161 gagaaacgaa ggaccaatcg attaataaat cgactagtat ccgcacctgg ataaatacca
    20221 taaatgtatt ctccagattt tttcatacgg tctgcaatct cttctccatt catcgtaaca
    20281 aaagcaaaaa tgatactaaa taaaaataag accgaaatat aaacatagac ccacaaaggc
    20341 ttcccaacca taaattcctt tgataaagcc gctagccctg aatgattagg gaaaataaat
    20401 cccaacaaga tgaacaaata agctggtaca ctaagaaaac tcatcacata catataaggc
    20461 atcccacctg caggattcaa catgatttcg agataagaat agcgtttaaa tcgattgtgt
    20521 aagccaattt tattaacagg aaccaaatag cgagctcgat acataagggc aagcaagtaa
    20581 gaaaatataa tggtcataaa aacaagcaag acaacaatcc ctgtagggat ataaaccagt
    20641 ttaaaagttt caataacatc ctgagggata tttaaaacaa tgctggatag gaggattaca
    20701 atagaacccc caattcccat gctcgcattt aaatctgaca accaaacaag aaaaaacgtt
    20761 cctgctatga gtaacaaggt attcattaga gcaaccaaaa ttaccgagta ggaggattgt
    20821 actggcaagc tcaagctaac tgccaaggat tgaatcacag caattagcaa ggtcagatac
    20881 attcttcgac gatcttgaat ttcaatcgct gtagaactta gccccaattt tttagaatat
    20941 gaaaacatct gccacaaaat catagctgac atccaagggg ataatccaac agaaaaaatt
    21001 gacaaacttc ttagatttcc acctgttagg gcggctgaga aggctagata ggctgttgaa
    21061 cctcctaaaa aatctttagt atttaggtca acaaaaggga gagtaatacg acttcccaat
    21121 acatagataa acagtagaaa taaggtaaat agtccttttt ttactgctat tgacgaataa
    21181 atcttagtca taaaacactc ccctcacctt cattgtttgt gatatggtaa ataacaattc
    21241 ttttatttca acttttacca tttctttgtt ctgcatcaaa aaacaacttt aatctgaaac
    21301 aaatatcttt atattcctca gtatctgtta attgatggta ttctaaagtt tgcttataat
    21361 cttttaaaag attgacaaat cgaatacgca gaacggagac atccaaacca gccaagatac
    21421 aatccgatat tttcttagaa aacacttcaa caatatctct tgcccaggaa agatcaaatt
    21481 ccgttctcat gatgcttcct gaacgtcttc tatacagata gagattatcg tttataaaga
    21541 cgattttaga ggctaaaaga taaaagcgat gcatagttgc ttcatcatca aagcggcgac
    21601 catttgaaaa gtgaacttca ttgaataatt cttttttaat caacttaaat gtcggcaata
    21661 taaaggccga gctattgaat ttccaatctc ctgcttgacg gttcataatt tcttgtatag
    21721 ctaattcttc gacgcaaaaa tcttgccctg ttacataaaa ataaaaattc ccgtcacttt
    21781 cgtcataatt atagtaattc cctataacaa catccgcatc cttttcttgg acttgctgat
    21841 aaagagtttc aatcatattt tcttttacga tatcatctga atcaacaatc gtgatgtact
    21901 ctcccttagc tacactaatc cccatatttt tagcttgtgc tgcccccccc ttattttctt
    21961 gatgcaatac tcgcacacga ttatcttgca tcataaaagc atcacaaatt tccccagaat
    22021 tatccgtaga actgtcatca actaaaataa tttctatatt ttgataggtt tgcttcagaa
    22081 tatgctcgac acactccact aaatattttc ccgtattgta tatcggtacc acaacactaa
    22141 ttaattcact cattactcta tctctatatt cttcattcta tccactaaat catctggtct
    22201 ctccacagaa aaaataccgt catagagtcc atcatccata cttttacgtg tgatatcaaa
    22261 agcgaagatt ttcttgccac tttcttgtgc ccttgtaact acattaaaaa cctctccacc
    22321 tgtattaata tctaaataaa ctatagaatc gtctaatagc caatcaattc tactatgtaa
    22381 tacattttga tatactgtta cattcgtata ctgtgataga gaggtcagct cctcagaaca
    22441 atcacacggt gcagccaaat gaaaatgcca atcaggtaac cgttgtacta aatactctaa
    22501 atgttttata tctgcactcc atgtcacaag catcacttgt tttttagact gattgcttct
    22561 ttcaaaataa tttaaatcgg aacgttgaaa agcaatctct gaccaatcca aatctctata
    22621 aacccaccat aattcacgta gtctagatat actatatgta ttccaaggtt tatcatgact
    22681 agcatagtga acaattgtag gtggattgtc atctagacgt tcacattctt gagcaaggtg
    22741 ataaatatca acacccacca tataattata tgttttatct aaggctagcc aattatcctc
    22801 aaaataaata tttaaaatac tctgatcccc aagatgaaca acttgattct gctcggccgc
    22861 taattccaat aaactattga ctatagaatg ttctttccat tttacaacat ccattagtaa
    22921 cataccagta ttaaatccag attttcgtcc ttcataggca tagacatcat caacagcacc
    22981 aattgaatat cctttgagat ctatctcaaa caaagtagct agttccccag ttacaatgat
    23041 atcggaatcc agatacaata ccctatcaga ttcaaccact tctgtcgcaa aaaatctaaa
    23101 gtaagaagca taatttatat gaggtcctgt tttgtagctt tcaaaaagtt ctttatcaat
    23161 gtgtacactg cgaattgtag aattcacaac ttccattttt ctccccaata atttaaacca
    23221 ttcaggagct atatcactgt tgagaatata aaaatcaaca tctctattgt gatacaatac
    23281 agactttata gtcgtctcta aaggaataag ataggcatta tctgccgcta atactattga
    23341 ttttctcata ctgttctcta cctcatgtaa gatctgattg ctgcaaccat ttttttcgga
    23401 atggagcttg gatagatacc ttcatatgaa atctcagaaa gattttcaga gcaagtattg
    23461 tcgaaagcta tcattgtttt tttgtactta agcacaaact catatgcatc ttctaatttt
    23521 cgatcatgat tcaaatccaa atacaaatct gaagctatta ctatttgttc caataacatt
    23581 ggtaaggaat ttggatatac ggtaacatta ggaaaacgcg ttaaagctag tagttcattt
    23641 gccatatttg tataagcaac aatatgaaaa tgaacttctg gcaattgctc cgccaaataa
    23701 tcgattttct cgacacacca agaattcgtt aaattaacac attgcaactt aaatatttgt
    23761 gatttactag gatacttcac actctttgaa aaccattcat ttaaaataac agaccaatcc
    23821 atcaaagagt attcccacca aacttctctt agacgtccaa cagaaaattg attccaaggc
    23881 ttatcctgag aaatatagtg taaaattagt ggcagtggtt cgagcggaat atcaaaaatg
    23941 aattgatgtt taaaggctgc cgccccataa tcatatccta tttgaaaatt atattgatct
    24001 tcaagggaac tatattgatc tttaaacaac atattcaaaa ttgactggtc tccttcttcc
    24061 acattctcat gttctttttc tgttaagtca atcaattttt gtcgaatagt ttcagatccc
    24121 cattttttgt tgttaatcaa gagaacacca gcattgaagc cgactcctgc tccaaagcaa
    24181 gaacgagctg ctgccaaata attttcacct aagtctaatt caaacaaatc ggtcaaatca
    24241 ccagtcacaa tcaaatcact atctagatag agaactttat cttctgttac aaaatctgga
    24301 ataaaatagc gtgcaaaggt catatgattg atatgaggca gtttattaga ccagttcatt
    24361 gtatactgtg agccaatcaa cttgcaatca atcaagtcgc cccccatctc ttgtaaatat
    24421 attcttattt gactaaacca ttcctgggga atgtcctgat tgagcaaata aattttcaaa
    24481 tgactattgt gtctacagag tgacttcatt gccgtttcga tttgtcgaat ataagcgtaa
    24541 tcacctgcaa atactacagc gcgtttggta tttctcattt taaatcctta tcatttattt
    24601 taaatagtct agtttaatat tcgtgcaaca atctgactgt tataggtttc atcatcaata
    24661 aattcaatat cttggtcgaa attatgttct gcagtatgtt tatgagaaaa tttaacctta
    24721 gttttagctc ccattttcat ccattcatac tctgagtcaa tatggcctac atccaaaact
    24781 tgatagccca tctggcatag attataactc agaacttttg ctgtaggacc cagcatacat
    24841 aaaataaggc gattttcagc atgtttcata atttcctctt gaatgttatc gacaacggaa
    24901 taagcattat gagatggaca aataatcctt ttcacagatt tgaccttatc aaataaatca
    24961 tttccaaccc cagagcgaga tgtaatcccc tctacaatca gaatatccct attctcccaa
    25021 atactcttta gcttttcaaa ttgtcctttt gccttactct tatcttcata atcaatgtat
    25081 ggacgcgaga taaaggtaga gccataccat gaacccttac acaactcttt ataaaaatcc
    25141 atataaacat tcatatgttc tttccagaat ggtgtagccc accaagtaaa gacaaaacga
    25201 tcgtcaaaag catcaggtaa acaaaccact aatttctcgt cactctcaag acccacaata
    25261 tgttttaatt ggttagctaa ctctagatca tgattttgat aaggtatagg caaaccccac
    25321 atcaaattga cttctccgtc tccaaaacga actaatgagg acttattttt gataacataa
    25381 tccagagtct gatcaattcc gataaccttg attggcttct ctggttctcc caaagtctct
    25441 ccttttatca atgcatgaaa tgcttgaaga agcctttctg gatgctcact tgaatataaa
    25501 tgttgaccat gatttccatt ttgtgaagta taaaatgcca gcattggttt attcaatgat
    25561 gatatctcct tgacaacctc actagtagaa ttgtgtaggt taatatccaa ataaacatcc
    25621 atttgagatt tgagttcttc aaattgatcg cttttcactt caggatatag cttaacattt
    25681 ttatattttt ttgctagttc ttgtaacatt ggtcccataa ctgtccaagc tgcgatatgg
    25741 aatgttacca taggaaaatt cttaacaaga taatctatct tttgcaattc ttgagaattt
    25801 gtaaatgtta ggcaatggaa atcactacct tcataacaac ttaggaatct tccatctctt
    25861 ctgtaatctt taatcgcttg aaccatgact gaaacttcat cttttttgaa tactagttgg
    25921 ccagtattcc catgttcagt cgtatcaaat gatggaattg gcttttctaa gatcttcata
    25981 tcctctaaaa tagtacctac cacatgactg tagttaatgt ccagatataa atctacactt
    26041 ctctccagct tatctaatac aggaggaaca atttgtggat gcaatctcac attattatat
    26101 acagctaatt gttttaattt atctcccata tccgtccaag ctgcgatatg aaataccacc
    26161 tcaggtagag ctgtaactag ctcttctatt ccttctaaat cttgggaatt cgttaaggtt
    26221 aagcaagaaa attccttatc tagaggcgat attagttcaa attctcccat atggtgttgt
    26281 aaaatctgac tccactccaa atcatggaat tcccaccata aatcacgata acgattggct
    26341 atcaaggtgg tccagggttt tctgtaggtc gtaaaatgaa tcaccactgg tttatcgtta
    26401 aaagccagat gttcctgcca attattatac aaagccacaa tatcatgccc tacttgtaaa
    26461 ttataagctc gacctagctc taaccaatca tcttgcaaga cttgattgaa aatcgtttga
    26521 tcaccattaa aatgctcgaa acggccttct tcaacttcct tcattgtaac aatgctctgt
    26581 tcaattagtc gttcttttaa tttctcttga cgccattttt tattgttgat taatagaaca
    26641 cctgtattaa atgtaattcc atctgtatct ttaactgctg cgagtgattt ttcttctaaa
    26701 caaatactaa ataatttctc taaagaagta tttacaatca aatcactgtc taaatataaa
    26761 accgtatctt cttggatata atctgcaata aaatatctag cataggtaat gctactaatg
    26821 tgatcttgct tttcccaatc ttgaaacaca gtttgttcag gtagtttaac atcgataatc
    26881 tcactaccta acatgcgagc tatttttcgt ggtttgcgaa accaatctgg cataatatct
    26941 tgatttaaaa tataaatctt aacatctcga ttgtggtata aaatagattt tatggttgtt
    27001 tctaactgcc tgatgtaatt acgatcacca gctaatacaa ttgttttaat catcttgttc
    27061 tcttattcaa ctcccaaatg gtaaattgca tctaccaata attttttagt aaaataacct
    27121 tcttttagca aataactaaa ggtttttatc cgattcgtca tttcttgata ttcttgtaga
    27181 ttcattttat caactatctc atgaacttcc tctagactat tcgccacaaa gcctaagcct
    27241 tgatctacta taaattcagc agttgacaag ctacttggta caatgactgg gatgcccgct
    27301 gtcagatagg tactcacctt atgagatata ttcaaggtat agtattggtt actttctccc
    27361 tcattttgat gggttcccca gacaaggcca aatccaccct ttgataattc tagcaacaat
    27421 tcctcatctt ttttccatcc ttcgatgctg agatttctag cactagaact agcttcccct
    27481 ttatttgaaa atactctcaa aggcgtatct tgagaccaat tttgtaagtc tggaaaacgc
    27541 tctaaacttc cagcaaaaaa aagttctttt ttaaaagcag gggtgtataa ggataaatca
    27601 tgaggatgat cccacatccc ttgaacaaga atcttcttag tcgtcaatcc ttcttccatc
    27661 aggcgtgttt tcattctctc tgatggcact atcaaaacat ctgatagatt atacatgtac
    27721 atatagtctt tcatgagata atagttacta tcaaacatga ggggaacaac atcatggata
    27781 aagcaaataa ttttcacctg catatccttt agcttgtcaa acaagagacg atcaaattca
    27841 aagccattcc aggttggaga ctgaaagact aaaatatccc caatagagat actggccata
    27901 ataccatcca gacgcttatt catttcagaa ggactatctg aagcaatgtt gtaaaaataa
    27961 ataccaacct ctctaaatcc cagttgacta gctatctttt gaacagcatt ttgagctaag
    28021 ataaccgtac tatcaccagc catgccgtat aaatttgtta aatgtaattt catattacgc
    28081 tatctcattt tttattacta tctacggaag taaagacaat ttttccatca ttcttctata
    28141 aatctctgtg aactgcatat tttgttcttc taattttgct atcactcttt gtaatctatt
    28201 tttataaatc aaaatatgat tggtcaagtc atagtctgaa cttgctaaaa tagctatctt
    28261 ttcttcccta gccccaattt catcatacat acgcttttca ctccatgtat tcgataaagt
    28321 atcagataaa ccaacacggt accagtaaac acaacgattc aaatagacta tcctcgaagc
    28381 tcttagaagt accttccatg tccagtaagt atcctctgca atttttccta taggaaatgg
    28441 taaatcttgt agtaactctc tcttgaataa cttcaagaca gctacagtcc agttcccatt
    28501 tctgacttct tcgacacctt ccctatccat gattgcttta ccttctatca cttccagaga
    28561 atcatctgga tccgtaacat aagtcatata cacatagcgt gtttcatcat aagaattata
    28621 acgcccgata ctaatatctg cgttttcctt tttcaaagca ccatataatc ggtctaaagc
    28681 atcatgttcc aaccaatcat cagagtctac aaaagtaatg tacgcccccc cccccgaaca
    28741 ttcaatacct aggttacgag ctgatgaaag accgccgttt gctttctcaa aatatttgaa
    28801 acgagaatct ttctctacaa attcttcaca tattttggat gaatgatctg gagagccatc
    28861 attgattaat aaacactcaa aattttgata cgtctgattc tgaatgctat ccaaacacat
    28921 tcgcaaataa ttctcaacat tgtagattgg aactacaata ctaattaatt catttcccat
    28981 atactaactt tcctagactt gatttattct atttccctct taatctcttc tttttacaca
    29041 aagattgcca ttattataaa ctacactgtt tgatggaata tcattgcgta tgagacaacc
    29101 tgctccaata atggtattat ctccaatcgt cactcctttt aaaatcgtga cattacttcc
    29161 tatccagcag tctctgccaa ctctaatcgg cgctgtagtc cactgccact tttcaatctt
    29221 ttcagcggta taaatatggt cgtgatcata aaaacgaaca ccctctccca tcatggtacc
    29281 agctccgatt tcaattcttt ccatacagtt aaaactacaa gagttgttga taaaaacacc
    29341 atcattcagg attaacttac cagaagagac atgaaaattt tcaaaatttc tacaggcgac
    29401 attggctcct acaatgaagt gagccttatc atcgatttta aagacattcc aagtcccatc
    29461 ttgaatgatt ttctcttgat gattggtgcc tactctgact tcattcagat agtctctcac
    29521 tctagaaacc aatttgtctg gtgtacttga tagaaaaact tcctgcccct gatttccatg
    29581 gactgtattg tcaaatgcaa agacagattt tccagcctgt acaaacttgg agacaatagc
    29641 atctacttct tgaaagtgat tgatatctag taaaaagtca caggtatcga ctaaaaagtt
    29701 tagctgttct tcatttgtaa tcgttcggag acggacatta tagttcgttt ctaagctacg
    29761 gattttctcg gaaaattgaa caggtgctgc aatatgaaaa cagatatttg acaaggattc
    29821 aaggagataa tccaactctt caatctgatc actaaccgtc aaaatcagag catctcctac
    29881 taaatgattt ttcttcattt gcttatttct ctcaatttct caatcattgc ttgaacttgg
    29941 tcaacagcat atgcctcctg acctacttca taggttttag tattttcaaa ggataagata
    30001 ggcttgccaa gattagcaaa ttgatcgaga atttcttctg tcttttcgcc atgattaata
    30061 tctaaaagta cttgactggt ttctaccaat tcattatcga catctaccaa atagtgaatt
    30121 ccgttaaata tagtcacgtt tggataaatt gtcatctgag ccaatcgatc actaactatt
    30181 actctagctg ctatcttaaa ctgaatatca gaccatattg aaccaatgtc tcaatttgtt
    30241 caatatggtc tgaggcagta tagattagac aagtgaaagg ttcctttatt ggatagatgt
    30301 gagatctttg taatggatgt aaatgatggt tttgtcccaa ttctgtccat tcaagcccat
    30361 gatagtacca ccaaacttca cgataagttt gggccgccaa atctttccac ggttttctat
    30421 gggaaagata gtgaataata gcaggataat cctgaccctc aggcaattga taatcagcaa
    30481 actgtttatg aatgacaata tgattataat caaaatccaa ttccagccat ttatgttcaa
    30541 aaagcatatt caagatgctc tgatctgcct gatccacctt atcatgccat tcattggtta
    30601 aatcaattaa tttttgggtc atattctctt ttttccaaaa agcattgttt accaagagaa
    30661 caccggcatt aaagatttct tgaccaaaat aagctctgcc cccaaaatct ctaacagcag
    30721 ccaaaggata atcttgtaag tctgtagcaa acaagtcatc cagatttttc gttacagcta
    30781 gatcacagtc caagtagagg gccttgtctt cttgcacgaa atcagctatg aaatagcgta
    30841 aaaagactgt gtaactaata tccgatttat aacatgaaat ttgctcagaa gttacccgac
    30901 aattaataat ttctgagtca aacttctcta atcgcttatt taattgtttg atccattcat
    30961 ttggaaaatc gctatgaatc aaataaaaac gaagcgagcg attgtggtaa cagatagacc
    31021 tgattgtcgt taaaacttgg tctacatagg cataattcgc cgctaggaca atggctttct
    31081 tttcacttga ttcttgtacc gttaactgat ttaaaagtct ttttttcatt tcaaactctt
    31141 tatacgttgc tgtgtcagat aaaccactag cttgaccgtt ggcgagactg aattccaaca
    31201 tttgacgata aatcgccaaa tgcttttcta aagggtaacc catattagct agtagcgtaa
    31261 tgcgttcgga catggcatca accaatgcat gcatccactt ttctgtccaa actcttgata
    31321 aactaccttt tctaatccga ttattcttca tcatcacgtt tacggcgttt cgcaaacaaa
    31381 cccaagccag tcacagctgc caaagctcca aggagtacag atgacttgga agcttctgta
    31441 cctgtatttg gcaattgctg tcttgactta cctgctgaag ttgacgcgct tgcgcttgtt
    31501 gatgccgatt cagacgctga agctgaggca cttgtacttg ctgaagctga tgcactcgtt
    31561 gacgctgact cagaagctga tgtgcttgct gaagccgagg cactggtgct tgctgaagct
    31621 gacgcactgg ttgatgctga agctgaggcg ctggttgacg ctgaagctga ggcgcttgtc
    31681 gatgctgaag ccgacgcact cgttgatgct gaagctgagg cactcgttga cgctgaagct
    31741 gaggcgctgg ttgacgctga agctgaggcg cttgtcgatg ctgaagccga ggcactcgtt
    31801 gatgctgaag ctgaggcact cgttgatgct gaagctgacg cactcgttga tgctgactca
    31861 gacgcacttg tgcttgctga ggctgacgca ctcgttgatg ctgactcaga cgcactcgtt
    31921 gacgctgaag ctgacgcact cgttgacgct gaaactgagg cgcttgtcga tgcagattca
    31981 gacgctgagg tgcttgctga ggctgaagca cttgttgacg ctgaggccga ggcgcttgtc
    32041 gatgctgaag ccgacgcact cgttgatgct gaagctgagg cactcgttga cgctgacgta
    32101 cttgcactcg ttgatgctga agctgaggca ctcgttgatg ctaaggctga agcacttgtc
    32161 gacgctgaag ctgacgcact cgttgacgct gaagctgagg cactcgttga tgctgaagct
    32221 gaggcgctgg ttgacgctga agctgaggcg cttgtcgatg ctgatgctga tgcgcttgtt
    32281 gatgcagatt cagaggcgct tgtcgatgct gaagctgagg cactcgttga ggctgaagct
    32341 gaggcactcg ttgatgcaga ttcagaggcg cttgtcgacg ctgaagccga cgcactcgtt
    32401 gatgctgact cagacgcact tgtacttgct gaagccgacg cactcgttga tgctgagact
    32461 gatgcgctgg tacttgctga ggctgacgca ctggttgacg ctgaagctga tgcgcttgtc
    32521 gatgctgaag ccgacgcact cgttgaggct gaagctgagg cactcgttga ggctgaagct
    32581 gacgcactcg ttgatgctga ctcagacgca cttgtacttg ctgaagccga cgcactcgtt
    32641 gatgctgaga ctgatgcgct ggtacttgct gaggctgacg cactggttga cgctgattca
    32701 gatgctgatg tgcttgctga ggctgacgca ctggtacttg ctgaagccga cgcactcgtt
    32761 gaggccgatt cagacgctga ggtacttgct gaagctgacg cact
//
LOCUS       DAVHSO010000022        32635 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.022, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000022 DAVHSO010000000
VERSION     DAVHSO010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32635)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32635)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32635
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.022"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            24..2003
                     /locus_tag="VVR18_000969"
     CDS             24..2003
                     /locus_tag="VVR18_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEU6032518.1"
                     /translation="MNVLNIKEKDILQFLIKNKERFVTSKELAEYLSCSDRTVRNVLK
                     LIEKTMIIQGVRLISKQGQGYQIFFENQGAYQEFRQTYELEEDYTKTAVSKGDDRLVF
                     ILNKLLFEQVPVLFDDLADELYVSRSTLSHDFRKIRVMLSEYNLSIESRANKGVYVSG
                     EERDKRRFIINYFLENQFFKTIHCYVKFNFFDQTVPLEEFARIVLDECQEANLKLSDF
                     VLQNLVVHIALSVIRLKSGFEIKNIDCQMTDDAIERKVAQRILSKVREVTNQEFPVQE
                     IDYITLHLLAKSQQCQKNQKNISEEVLKKSLFKTFQNLGLDDMYNFSLDFQLIEGLIT
                     HLMTLQVRLESRITLNNPLVDEIKQNYSDIFFMTREILANMDKFLEWTISDDEVAYVS
                     LHFLAAMERSKESTKFNILAICATGFGAAQMLRNRLETEFGKRVEVVDVIGYYELNQE
                     KLKGIDFIVSAVDLSNLYFQIPVFKVSVFLKSDEMEMIRKAMDQMQVSSYVQSSKINK
                     FENNSFRQYFSKENFLICTESDKVNLLEKMVEGLSVGESNEFEQSLLYGIKQREELSS
                     VVFSEKIAVPHPIQPFGTEGKVSVAICKDSLLWDNQSSHVQLVFLLSPSIYGNEGLAT
                     VTKKIVSLTENDELQNQLISCNNFEDFINIFEKIK"
     gene            2013..2327
                     /locus_tag="VVR18_000970"
     CDS             2013..2327
                     /locus_tag="VVR18_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIA"
                     /protein_id="HEU6032519.1"
                     /translation="MNQEELQVAAFEIILHSGNARSEIHEAFAKMREGSFDDAESKLN
                     QSNEIILEAHHAQTKLLQEYASGVEIKIEIIMVHAQDHLMTTMTLLEVAKEMLALYKK
                     VN"
     gene            2358..2864
                     /locus_tag="VVR18_000971"
     CDS             2358..2864
                     /locus_tag="VVR18_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032520.1"
                     /translation="MDKKERQKIEQQRREMALTNTFFNRYLLLRYSIALFFFGNIYWL
                     LNQFISPSPIIIFPIMLIVFSILATIEQFKLYGNRKEKLGITLMFVRIQMLISIGLLV
                     LTWTSWFKNLFPIFENNQVARLFVFVVLLLGLVLSLLDIRRIKKIYKRTDKAYQQFVQ
                     LEKNSLSL"
     gene            2944..4290
                     /gene="celB"
                     /locus_tag="VVR18_000972"
     CDS             2944..4290
                     /gene="celB"
                     /locus_tag="VVR18_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIC"
                     /protein_id="HEU6032521.1"
                     /translation="MDQQNGLFGFLENHVMGPMGKLAQFKVVRAITVAGMAAVPFTIV
                     GSMFLVFSILPQAFSFWPIVADIFSASFDKFTSLYMVANYATMGSLSLYFVLSLAYEL
                     TKIYAEEEELNMNPLNGALLALMAFVMTVPQIIFDGGMMKTVTSLKEGAVIADGWAMG
                     NGVARFGTTGIFTAIIMAIVTVLIYRMCVKHNWVIKMPEAVPEGVSRGFTALVPGFVV
                     AFVVIFINGLLVAMGTDIFKVIAIPFGFVSNLTNSWIGLMIIYLLTQLLWIVGIHGAN
                     IVFAFVSPIALANMAENAAGGHFAVAGEFSNMFVIAGGSGATLGLCLYIAFASKSEQL
                     KAIGRASVVPALFNINEPLIFGLPIIYNPALAIPFILAPMVTATIYYVANSLNFIKPI
                     IAQVPWPTPVGIGAFLGTADLRAVLVALVCAFAAFLVYLPFIRVYDQKLVKEEQGI"
     gene            4670..4846
                     /locus_tag="VVR18_000973"
     CDS             4670..4846
                     /locus_tag="VVR18_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032522.1"
                     /translation="MSLDIDKEKMTIMGIAFENRSVFKSVWYALSTNMIEGWRPTVSD
                     VEKLRDEALALGMT"
     gene            5248..7461
                     /locus_tag="VVR18_000974"
     CDS             5248..7461
                     /locus_tag="VVR18_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 31 protein"
                     /protein_id="HEU6032523.1"
                     /translation="MKIFKGEFYRISVLTDKLVRLEYSQTGSFEDRTTQLIYNRDFGQ
                     ISLDYIETSNVLDIMTDYFHLHFNKGEFNAENLFIELKGNFAVYGSRWYFGESIETLK
                     GTARTLDKADGAISLEDGIISRNGIALLDDSQGFIWDEQSGYIERENQIDLYFFAYGH
                     DYRGAIRDFYHLTGSTPLLPRYALGNWWSRYWPYTSDEYLDLIDRFETEKIPLSIGVL
                     DMDWHITDIPARFGSGWTGYSWNRNLIPNPEQLLQQLHDRKLKLSLNVHPADGIRAYE
                     EAYPQIAKRLGLNVELEEPAIFDFFNPSFRKAYFKDVHYELEKQGVDFWWIDWQQGTQ
                     GMLDPLWLLNHYHYQDSCKNAEGGLILSRYAGPGSHRYPVGFSGDTIISWNSLRFQPY
                     FTATASNIGYSWWSHDIGGHMLGDYDEELQTRWLQFGVFSPITRLHSSRSPFNSKEPW
                     FFSETTSKIMKKYLRLRHQMIPYLYTMNVKTHEEGAPLISPIYYFYPENDESYNVPNQ
                     YFFGTELMVAPIVEKMDLTFQSAKVDVWFPEGEWYDFFSDKKYTGGVKLSVYRDISTT
                     PVFAKSGAIIPLVGSEIGMGVDLPEVVDWYVFPGKQHSFEMLEDQNGQRYKTRLSIDW
                     EMGMVELALQGDSSIVPSNRKHRIHFKGTNVSIIELPNKNDTAKFEWKDNKRTSLNDE
                     VFRLLKTASLPYELKDRLLNQFINAKNSHDLMNILHHQDKELRGRLLEMIFTSQN"
     gene            complement(7683..8159)
                     /locus_tag="VVR18_000975"
     CDS             complement(7683..8159)
                     /locus_tag="VVR18_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione peroxidase"
                     /protein_id="HEU6032524.1"
                     /translation="MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQG
                     LQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKE
                     ADPLYVWLQDQKSGPLGKRIEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL"
     gene            8382..11585
                     /locus_tag="VVR18_000976"
     CDS             8382..11585
                     /locus_tag="VVR18_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored hyaluronate lyase"
                     /protein_id="HEU6032525.1"
                     /translation="MQTKTKKLIVSLSSLVLSGFLLNHYMTVGAEETTTNTIQQSQKE
                     VQYQQRDTKNLVENGDFGQTEDGSSPWTGSKAQRWSAWVDQKNSSADASTRVIEAKDG
                     AITISSPEKLRAAVHRMVPIEAKKKYKLRFKIKTDHKVGIAKVRIIEESGKDKRLWNS
                     ATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQLSEDSQT
                     DKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKE
                     VKKIPLKILASVKDAYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSI
                     SSQADRTYLWEKFSNYKMSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSME
                     WMHKHVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDP
                     EHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGF
                     YQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAP
                     LLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQ
                     SDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRTSYLSAFNKMDKTAMYNAEKGFGF
                     GLSLFSSRTLNYEHMNKENKHGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTE
                     TDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFL
                     GSNIQNTSTDTAATTIDQRKLESSNPYKVYVNDKEASLTEQEKDYPETQSVFLESSDS
                     KKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNGDSYGYM
                     LIPNVGRATFNQMIKELESSLIENNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVL
                     KRGVYTIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQAAQPQVQNSKEKEKSEEEKN
                     HSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN"
     gene            11964..12349
                     /gene="tnpA"
                     /locus_tag="VVR18_000977"
                     /pseudo
     CDS             11964..12349
                     /gene="tnpA"
                     /locus_tag="VVR18_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005816675.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
     gene            complement(12728..13357)
                     /locus_tag="VVR18_000978"
     CDS             complement(12728..13357)
                     /locus_tag="VVR18_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="HEU6032526.1"
                     /translation="MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEI
                     AYTNQYAGQIIKELVDLYQDDQSVCIGAGTVLDAVTARDAILAGANYVVSPSFHAETA
                     KMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSTLSPAYISAVKAPIPQVSVMV
                     TGGVGLNNIPQWFAAGADAVGIGGELNKLASQGNFDRISEIAQQYVTLR"
     gene            complement(13367..14368)
                     /locus_tag="VVR18_000979"
     CDS             complement(13367..14368)
                     /locus_tag="VVR18_000979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HEU6032527.1"
                     /translation="MTKILLFGEPLIRISPLDATSIGDHVASSTYFGGSEINIACNLQ
                     ALGISTKVFTALPANEIGDRFLTFLKQHQIDTSSICRLGDRIGLYYLENGFGCRQSEV
                     FYDRKHTSISQIRPNMLDMDSLFQGISHFHFSGITIAIGQEVRAILLLLLEEAKRRGI
                     VVSMDLNLRTKMISALEAKYEFSKFARFTDYCFGIDPLMIDDQNLEMFPRDSASLEEV
                     ENRMRLLKETYGFKAIFHTLRSSDEQDKNVYQAYALEERFEESVQLKTAVYQRIGSGD
                     AFISGALYQLLHHSSLKTTIDFAVASATLKCTLPGDHLSTSATSIENLLANAQDIIR"
     gene            complement(14399..15040)
                     /locus_tag="VVR18_000980"
     CDS             complement(14399..15040)
                     /locus_tag="VVR18_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="HEU6032528.1"
                     /translation="MKIALINENSQASKNHIIYDSLKEATDKKDYQLFNYGMRGEEGE
                     SQLTYVQNGLMAAILLNTKAVDFVVTGCGTGVGAMLALNSFPGVVCGLAVDPTDAYLY
                     SQINGGNALSIPYAKGFGWGAELTLKLMFERLFAEEMGGGYPRERVIPEQRNARILNE
                     VKQITHNDLMTILKTIDQDFLKDTISGKYFQEYFFENCQDDEVAAYLKEVLAK"
     gene            complement(15059..15874)
                     /locus_tag="VVR18_000981"
     CDS             complement(15059..15874)
                     /locus_tag="VVR18_000981"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="HEU6032529.1"
                     /translation="MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVF
                     NDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGI
                     IRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRET
                     VSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFD
                     QFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE"
     gene            16145..16579
                     /locus_tag="VVR18_000982"
     CDS             16145..16579
                     /locus_tag="VVR18_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6032530.1"
                     /translation="MKIVLVGHGHFATGIYSSLQLIAGNQENVEAIDFVEGMSADELK
                     QKILLAISNEEEVLILSDLLGGSPFKVSSTIMGENPAKTMNVLSGLNLAMLMEAVFAR
                     MAHSFDEVVNKSVVAAQGGVVNGKELFSTDAEEEEEDFESGI"
     gene            16591..17781
                     /locus_tag="VVR18_000983"
     CDS             16591..17781
                     /locus_tag="VVR18_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003074342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="HEU6032531.1"
                     /translation="MIKKVTIEKIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDY
                     FKEDFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYEYSQQDAFKNIAHKNVLSFLDR
                     VNKRVELAHHDLGFLYTPSCMAEYKINGDGEAREAALKAADKLIERYQEKGGFIQAWG
                     DLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHT
                     FYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNY
                     FLNRLPKDHVSYWDLIFNDGSDQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAM
                     HAMLRSLIEHYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDW
                     NLYW"
     gene            17792..18283
                     /locus_tag="VVR18_000984"
     CDS             17792..18283
                     /locus_tag="VVR18_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000178618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEU6032532.1"
                     /translation="MTMPNIMMTRIDERLIHGQGQLWVKYLGCNTVIVANDEVSTDKM
                     QQTLMKTVVPDSVAMRFFPLQKVIDIIHKANPAQTIFIVVKDVKDALTLVEGGVPIKE
                     INIGNIHNATGKEQVTRSIFLGEEDKAALKELNQTHQVTFNTKTTPTGNDGAVQVNIM
                     DYI"
     gene            18298..19077
                     /locus_tag="VVR18_000985"
     CDS             18298..19077
                     /locus_tag="VVR18_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEU6032533.1"
                     /translation="MSINVFQAILIGLWTAFCFSGMLLGIYTNRCIVLSFGVGIILGD
                     LPTALAMGAIGELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVSPEAALALST
                     PIAVAIQFLQTFAYTVRAGAPETAMKHLKNHNLKKFKFTLNATIWLFAFIGFTLGCLG
                     ALSMDTLLKLVDYIPPVLLTGLTVAGKMLPAIGFAMILSVMAKKELIPFVLLGYVCAA
                     YLNIPTIGIAIVGTIFALIEFYNKPKTADHVVEEEAHDDWI"
     gene            19064..19882
                     /locus_tag="VVR18_000986"
     CDS             19064..19882
                     /locus_tag="VVR18_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU6032534.1"
                     /translation="MTGSNKLTKRDYLKTSLRAFFCQNGFNYSNYQGLGYANVMYPAL
                     KKHYGEDQEGFYQALEENCEFYNTNPHFLPFITSLHLVMLENGRPAKETRSIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASFAQEGLVVGPILFFLAMNTILTAIKLSTGLYGYK
                     LGTTVIDKLSEQMATISRIANIIGVTVIAGLAATSVKIMVPITFAAGEVKADAKQSIV
                     SIQGMLDKVAPALLPALFTLLVYYLIKEKKWTTYKLVILTVIIGIIGSWLKIIA"
     gene            19882..20175
                     /locus_tag="VVR18_000987"
     CDS             19882..20175
                     /locus_tag="VVR18_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000381741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEU6032535.1"
                     /translation="MDTTLFYGIVIVLAVSPLLLSSFHSIRQQKLLRKQMEQRQEYLA
                     SLTSGDEVLLLSGIHGKIISIQDDLVSLQIAKGVVIYVEKESVMGKTKELLFK"
     gene            20197..22098
                     /locus_tag="VVR18_000988"
     CDS             20197..22098
                     /locus_tag="VVR18_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="HEU6032536.1"
                     /translation="MKEERRQFFERIDGNQCRDYILSHCSKDYEKVKSSLERLMDNRF
                     MFDSPWDMEPCSKIHQIQPMVWDQVFEDDPEWAYMLNRQEYLLQFMIGYVVEGDKDYI
                     QKCKFFLFDWIEQVREFSPQSLMTRTLDTGIRSFTWLKLLLLLLKFDLLEEKELEKIL
                     VSLEKQIDFMKSYYRAKYTLSNWGILQTIPMLAIYHFFSDKMDLEEAYHFASEELKQQ
                     IETQILGDGSQFEQSILYHVEVYKALLDLCLLLPDLQDSYQELLEKMATYIQMMTGLD
                     GRTLAFGDSDSTETTEMLSLSAVVLNKEDLLNGLDVKVDLLSLLFLGREKVKRLQEFE
                     RRAWQPKSMIFEDSGHVCIKDEHRYLFFKNGPLGSAHSHSDENSFCLQYQGQPIFIDA
                     GRYSYREIYERYLLKSAWSHSTCIVDGKAPERITGSWEYEYYPHSLFCHHKEREGVHY
                     IEGAYWSAEPDLPYLHKRKILMLVEDVWLLVDDIRCQGQHEALIQFILDKDVTYQDGK
                     INQLRLWSEVDFDLEDTIISPKYNELERSSKLTKRQFFENQMLDYTIIAHESFEIIRH
                     SVYQTDDREVENALAFEVKNDETDKLILLLSEDIGVGEKLCLVDGTKMRGKCLVYDKI
                     NERMIRLQC"
     gene            22158..23159
                     /locus_tag="VVR18_000989"
     CDS             22158..23159
                     /locus_tag="VVR18_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU6032537.1"
                     /translation="MEKKLTIKDIAEMAQTSKTTVSFYLNGKYEKMSQETREKIEKVI
                     HETNYKPSIVARSLNSKRTKLIGVLIGDITNSFSNQIVKGIEDIASQNGYQVMIGNSN
                     YSQESEDRYIESMLLLGVDGFIIQPTSNFRKYSRIIDEKKKKMVFFDSQLYEHRTSWV
                     KTNNYDAVYDMTQSCIEKGYEHFLLITADTSRLSTRIERASGFVDALTDANMRHASLT
                     IEDKHTNLEQIKEFLQKEIDPDEKTLVFIPNCWALPLVFTVIKELNYNLPQVGLIGFD
                     NTEWTCFSSPSVSTLVQPSFEEGQQATKILIDQIEGRNQEERQQVLDCSVNWKESTF"
     gene            complement(23269..23604)
                     /locus_tag="VVR18_000990"
     CDS             complement(23269..23604)
                     /locus_tag="VVR18_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000838135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032538.1"
                     /translation="MKSLARLLIIHVFISIFLFFALISGAVSHTVLLLLLLFLPALNK
                     GLEKIQSKRIPVLNAALFFLLISFPQLLTNPVQWKFSIFLVVTIISSLAYFYNFYQVV
                     KEVDQKQLI"
     gene            complement(23615..23857)
                     /locus_tag="VVR18_000991"
     CDS             complement(23615..23857)
                     /locus_tag="VVR18_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032539.1"
                     /translation="MKKEKRQLRYPGLKAGSIYGTVIFFIIPLIDTLTSENPNFISSL
                     LNTKHIFKTILGAFFFGVMIHIVDSLRIARAKKDQD"
     gene            complement(23868..24410)
                     /locus_tag="VVR18_000992"
     CDS             complement(23868..24410)
                     /locus_tag="VVR18_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3278 domain-containing protein"
                     /protein_id="HEU6032540.1"
                     /translation="MKKETFTEKLIKRTYGISGPLDEYKRREADSIGNQVFIVLFYLM
                     IFGNIIPLLLAYKYPQEVALIYPPLILVIALIASGYVTYQMKKTGITVIEPDMLNEKE
                     SKQLHYPGLKAGLFFGLWMFFITPLLSILIDEGQDYFHSLLTIRNGVSSILGSIFFGA
                     SIQFLISRRIAKTKKNQDED"
     gene            complement(24426..24620)
                     /locus_tag="VVR18_000993"
     CDS             complement(24426..24620)
                     /locus_tag="VVR18_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032541.1"
                     /translation="MNRVKEFRKELGISQLELAKDIGVSRQTINMIENDKYNPTLELC
                     LNLARSLQTDLNSLFWEEDF"
     gene            24786..25736
                     /gene="rsmH"
                     /locus_tag="VVR18_000994"
     CDS             24786..25736
                     /gene="rsmH"
                     /locus_tag="VVR18_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HEU6032542.1"
                     /translation="MTKEFHHVTVLLHETIDMLDVKPDGIYVDATLGGAGHSEYLLSK
                     LSEKGHLYAFDQDQNAIDNAQKRLAPYIEKGMVTFIKDNFRHLQARLREAGVQEIDGI
                     CYDLGVSSPQLDQRERGFSYKKDAPLDMRMNQDASLTAYEVVNNYDYHDLVRIFFKYG
                     EDKFSKQIARKIEQAREVKPIETTTELAEIIKLVKPAKELKKKGHPAKQIFQAIRIEV
                     NDELGAADESIQQAMDMLALDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPD
                     DLKPKMELVSRKPILPSAEELEANNRSHSAKLRVARKIHK"
     gene            25748..26065
                     /gene="ftsL"
                     /locus_tag="VVR18_000995"
     CDS             25748..26065
                     /gene="ftsL"
                     /locus_tag="VVR18_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsL"
                     /protein_id="HEU6032543.1"
                     /translation="MAEKMEKTGQILQMQLKRFSRVEKAFYFSIAVTTLIVAISIIFM
                     QTKLLQVQNDLTKINAQIEEKKTELDDAKQEVNELLRAERLKEIANSHDLQLNNENIR
                     IAE"
     gene            26069..28321
                     /gene="pbpX"
                     /locus_tag="VVR18_000996"
     CDS             26069..28321
                     /gene="pbpX"
                     /locus_tag="VVR18_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2X"
                     /protein_id="HEU6032544.1"
                     /translation="MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNF
                     AVIIGTGTRFGTDLAKEAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDE
                     NYKSATGKILYVEKTQFNKVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITY
                     ANMMSIKKELEAAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSG
                     MESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQ
                     MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITEDFVWRDILYQSNYE
                     PGSTMKVMMLAAAIDNNTFPGGEVFNSSELKIADATIRDWDVNEGLTGGRMMTFSQGF
                     AHSSNVGMTLLEQKMGDATWLDYLNRFKFGVPTRFGLTDEYAGQLPADNIVNIAQSSF
                     GQGISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARKSQKEIVGNPVSKDAA
                     SLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQIADEKNGGYLVGLT
                     DYIFSAVSMSPAENPDFILYVTVQQPEHYSGVQLGEFANPILERASAMKDSLNLQTTA
                     KALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQPIVVGTGTKIKNSSAEEGKNLAP
                     NQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEFQGSGSTVQKQDVRANTAIKD
                     IKKITLTLGD"
     gene            28323..29303
                     /locus_tag="VVR18_000997"
     CDS             28323..29303
                     /locus_tag="VVR18_000997"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HEU6032545.1"
                     /translation="MFISISAGIVTFLLTLVGIPAFIQFYRKAQITGQQMHEDVKQHQ
                     AKAGTPTMGGLVFLITSVLVAFFFALFSSQFSNNMGMILFILVLYGLVGFLDDFLKVF
                     RKINEGLNPKQKLALQLLGGVIFYLFYERGGDMLSVFGYQVHLGIFYIVFALFWLVGF
                     SNAVNLTDGVDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLSFFIFNHKP
                     AKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKR
                     IFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLM"
     gene            29912..32017
                     /locus_tag="VVR18_000998"
     CDS             29912..32017
                     /locus_tag="VVR18_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEU6032546.1"
                     /translation="MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEAF
                     AHYRATGQLPGNAETDVQMPQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEI
                     QETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
                     EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQ
                     HHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREI
                     ETEKDKQEKAVEAEDFEAALNYKTRIAELERKIENHTEDMKVTASVNDVAESVERMTG
                     IPVSQMGASDIERLKDMAHRLQDKVIGQDKAVEVVARAIRRNRAGFDEGNRPIGSFLF
                     VGATGVGKTELAKQLALDMFGTQDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSN
                     TLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVIIATS
                     NAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLA
                     EVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLD
                     AKHLEADMEDGVLVIREKA"
     gene            32469..32635
                     /locus_tag="VVR18_000999"
                     /pseudo
     CDS             32469..32635
                     /locus_tag="VVR18_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
BASE COUNT        10201 a         5537 c         7123 g         9774 t
ORIGIN      
        1 gaaaacatac gttttaggag ggaatgaatg tgttaaacat taaagagaaa gatatccttc
       61 aatttttaat aaaaaataag gaacgttttg ttacaagcaa agaactggca gaatatttat
      121 cctgttcaga tagaactgtc cgtaatgtac tgaaattaat tgagaagaca atgattattc
      181 aaggagtccg gttgatttca aaacaaggtc aagggtatca aatatttttt gagaatcaag
      241 gcgcttacca ggagtttaga caaacttatg aactggaaga agactatacg aaaactgcgg
      301 tttcaaaagg tgatgatcgt ttagtattta tcttaaataa attattattt gagcaagttc
      361 cagttctttt tgatgattta gctgatgaac tttacgttag tcgttcaaca ttatctcatg
      421 atttcagaaa gatacgagtg atgttatcag agtataattt gtccattgag agtagggcga
      481 ataaaggagt ttatgtctca ggcgaggaac gtgataaacg acgttttatc ataaattatt
      541 tcctagagaa tcaatttttt aaaacaatac attgctatgt aaaatttaac ttttttgatc
      601 aaactgttcc attagaagaa tttgctagaa ttgttttgga tgaatgccaa gaggccaacc
      661 taaaactatc tgattttgta ctacagaatt tagtagttca catagcattg tctgtgattc
      721 gtttaaaatc cggatttgaa ataaaaaata tagactgtca gatgactgat gatgcaatag
      781 agagaaaggt tgcccaaaga attctttcta aagtaagaga agtaacaaat caggaatttc
      841 cagttcagga aatagactac attactttgc atttgttagc taagagtcaa caatgtcaaa
      901 aaaatcagaa gaatatttct gaagaagttt taaaaaaatc tttatttaaa acatttcaga
      961 atttaggatt agatgatatg tataactttt ctttagattt ccaactaatt gaaggattga
     1021 taactcatct aatgacacta caagtacgtt tagaaagccg gattacctta aataaccctt
     1081 tggtagatga aattaaacag aattatagtg atatattctt tatgactaga gaaattcttg
     1141 caaatatgga caagttcttg gagtggacaa tatcagatga tgaagtagca tatgtaagtc
     1201 ttcacttttt agctgctatg gaacgtagca aagagagtac taagtttaat attcttgcta
     1261 tttgtgcaac aggatttggt gcagcccaaa tgttaagaaa tcgtttggaa acggagtttg
     1321 ggaagcgagt agaagttgtt gatgtaatag gctattatga attgaatcaa gaaaaactta
     1381 aaggaataga ttttatagtg tcagctgttg atttatcaaa tctatatttt caaatcccag
     1441 tttttaaagt tagtgtgttt cttaagagtg atgagatgga aatgattaga aaagctatgg
     1501 atcagatgca agtttctagt tatgtacaat catcaaagat taacaaattt gaaaacaaca
     1561 gctttagaca gtattttagt aaagaaaatt ttttaatatg tactgaatca gacaaggtaa
     1621 atttacttga aaagatggtt gagggtttat ctgttggtga atcaaatgag tttgaacaat
     1681 ctttacttta tggaattaaa cagcgcgaag aattaagttc agttgttttt tctgaaaaaa
     1741 ttgcagttcc gcatcctatt cagccctttg gtacagaggg aaaggtttcg gttgcaatct
     1801 gtaaagattc gttactctgg gataatcaaa gttcacatgt ccagctagta tttcttctat
     1861 ctccatcaat atatgggaac gaaggtttgg caactgtgac taaaaagata gtctctctga
     1921 cagagaatga tgagttgcaa aatcagctaa tatcttgcaa taactttgaa gattttatta
     1981 acatatttga gaagataaaa taggaggttc atatgaatca agaggaactg caggttgcag
     2041 catttgaaat tatcctgcat tcgggaaatg caaggtcaga aatacatgaa gcatttgcaa
     2101 aaatgagaga aggtagtttt gatgatgcag aaagtaaatt aaatcaatca aatgagataa
     2161 ttcttgaagc gcatcatgca caaaccaaac tcttgcaaga atacgcaagt ggagtggaaa
     2221 ttaaaattga aattatcatg gtacatgctc aagatcattt aatgaccact atgacattat
     2281 tagaagtagc aaaggaaatg ttagctcttt ataagaaagt taactaaata tgtgttgtta
     2341 tataaggagg aaatgatatg gataaaaaag aacgacaaaa gattgaacaa caacgtcgag
     2401 agatggctct aactaatact ttttttaatc gatatcttct tctacgttat tcaatagcac
     2461 tcttcttttt tgggaatatt tattggcttt tgaatcagtt tattagtccc tcgcctatta
     2521 ttattttccc cattatgctc atagtatttt ctattttagc aactattgaa caatttaaac
     2581 tttatggaaa taggaaagaa aagttgggaa taacactaat gtttgttaga atacaaatgc
     2641 ttatttcaat aggattactt gttttaactt ggacaagttg gtttaagaat ctttttccga
     2701 tttttgaaaa taaccaagta gcacgtttat ttgtttttgt agttcttcta ttaggtttag
     2761 ttctgagttt gttagacatt agaagaatta aaaaaattta taaacgaaca gataaggctt
     2821 atcaacaatt tgtccaattg gaaaagaact cacttagttt ataatcctga actagtataa
     2881 tttgtatttg aaactagtct ttaaaaagta aaaattatta tgttttatta aggaggtcta
     2941 tttatggatc aacaaaacgg gttgtttggt tttcttgaaa accatgttat gggaccaatg
     3001 ggcaaacttg ctcagtttaa agtagtacgt gctatcacgg ttgcaggtat ggctgctgta
     3061 ccatttacta ttgtaggatc aatgtttttg gtattcagta ttttgccaca agctttctca
     3121 ttttggccaa ttgtggcaga tattttctct gcttcatttg ataaattcac atcactttac
     3181 atggttgcaa actatgcgac tatgggttct ctatctcttt atttcgttct atcacttgca
     3241 tatgaattga caaaaattta tgcagaggaa gaagaactca atatgaatcc tcttaatggt
     3301 gccttgcttg ccttgatggc ttttgtcatg acagtaccgc aaatcatttt tgatggtgga
     3361 atgatgaaga ctgtgacaag tctaaaagaa ggtgcagtaa ttgcagatgg atgggcaatg
     3421 ggaaatggag tcgcacgttt tgggacaaca gggattttta ccgcaatcat tatggcaatt
     3481 gtgactgttc ttatttatcg tatgtgtgtt aaacataatt gggttattaa aatgcctgaa
     3541 gctgttccag aaggagtttc tcgtggattt accgctttgg ttccgggatt tgttgttgca
     3601 tttgttgtta tctttatcaa cggtcttctt gtagcaatgg gaacagatat ttttaaagtc
     3661 attgcaattc catttggttt tgtatccaat ctgactaatt cgtggattgg tttaatgatt
     3721 atttatctat tgactcaact actttggatt gtaggtatcc acggtgcgaa cattgttttt
     3781 gcatttgtta gtccaattgc tcttgctaac atggctgaaa atgctgctgg cgggcacttc
     3841 gctgttgcag gtgaattttc taatatgttt gtaattgcag gtggttctgg tgcaacttta
     3901 ggactatgtt tatatattgc ttttgcctct aaatctgaac agcttaaagc aataggacga
     3961 gcatctgtag ttccagcctt atttaatatt aatgaaccat taatttttgg attacctatt
     4021 atctataatc cagccttggc tataccattt attttagcac caatggttac tgctactatt
     4081 tattacgtag cgaattctct aaactttatt aagccaatta tcgcacaggt tccatggcca
     4141 actccagtag ggattggagc tttcttaggg acagcagatc ttcgagctgt attagttgct
     4201 ctagtatgtg catttgcagc attcctagtc tatcttccat tcatccgtgt atatgatcaa
     4261 aaattggtga aagaagagca aggtatctaa taagtaaaaa agtatactcg atgatagaat
     4321 ccatatagtt taaataatga gcgttaacat tagcagtgaa gaggtctttt taagatattc
     4381 ttctctgctt tttcatattt tttcgttatg tagggtatga agcaaaatag aaagtagttc
     4441 gaatagttga taaacaggga attgctgtta tttaaaaaaa acaataaagt aaagtatgtt
     4501 atcgtagaat acgatacaat agtaaaaaag caaaaagaat gcgttttata tttgggtttg
     4561 aggcttataa aataggataa gcgtgctgaa aacttagata tgacaaacaa aataaaattt
     4621 ttaaaagcta cagagaaaca tggtataatg catctaaagg aggtagcata tgtccttaga
     4681 tatagataaa gaaaagatga caatcatggg aatagctttt gaaaaccgat ccgtttttaa
     4741 gagtgtttgg tatgctttaa gtacaaatat gattgaagga tggcgaccta cggttagtga
     4801 tgttgaaaaa ttacgagatg aagctcttgc tctggggatg acttaatgaa gcgcaactgt
     4861 tatgagtctt atgactatgt tgatccggat aatttatata ccgatccggg ttcttcagtt
     4921 ctaagaaata agcaggaagg aaaaaagcac gcgagcttga atatcgtatg attgctagta
     4981 agagtttgaa attatttatc aatcctatct tagttaatag tttaaaagta gtttgtttca
     5041 caactgcata agcttagaaa agttgaaaag tgataactct ttaataaact cttggtttgt
     5101 taaaagatat tttgtccact acattttttt caattgacta ttgtttgtca tagatataac
     5161 agatagaaca ttgcattcag aataatgaaa aacgcatcaa aaatggtgcg ttctgttttt
     5221 atgctaccat aaaaggagga aaacaaattg aaaattttta agggagagtt ttatcgaatc
     5281 tctgtattaa cagacaagct agtaaggtta gaatactctc aaactggaag ttttgaggat
     5341 agaacgacac aacttatcta taatagagat tttggccaaa tttcgttaga ttatatcgag
     5401 acatcaaacg tactagatat tatgacggac tattttcatc tgcactttaa taaaggagaa
     5461 tttaacgccg aaaatttatt tatagaatta aaaggaaatt ttgccgtata tggtagtcgc
     5521 tggtattttg gtgaatctat tgaaacgtta aaaggaacag ctcggactct ggataaggca
     5581 gatggagcaa tctcgttaga agatggaatt attagccgaa atggtatagc cttattggat
     5641 gattctcaag gatttatttg ggatgaacaa tctggttata ttgagagaga aaatcaaatt
     5701 gacctgtatt tctttgccta tgggcatgat tatagaggag caatcagaga tttttaccat
     5761 ttgactggtt caacaccctt gttgccaaga tatgctttag gcaattggtg gagtagatat
     5821 tggccttata cgtcggatga atacttggat ttaatagaca gatttgaaac agagaaaatt
     5881 ccattatcta tcggtgtgtt agatatggat tggcatataa ctgacattcc agctcgcttt
     5941 ggaagtggct ggacaggata tagttggaat agaaacttaa taccaaatcc agaacagtta
     6001 ttgcaacaac ttcatgatag aaagctaaaa ctctccttaa atgtccatcc tgctgatggg
     6061 atacgggctt atgaagaagc ttatcctcaa atcgcaaaac ggttggggtt aaatgtagaa
     6121 ctagaagaac ctgctatttt tgattttttt aatccctctt ttaggaaagc ctactttaaa
     6181 gatgttcatt atgaactaga aaagcaggga gtagattttt ggtggattga ctggcaacaa
     6241 gggacacaag gtatgctaga tccactttgg cttttaaacc attatcacta tcaggatagt
     6301 tgtaaaaatg cagaaggtgg tttgatttta tcaagatatg caggtcctgg tagtcaccgc
     6361 taccctgttg gtttttcagg ggatactatt attagttgga attccttaag atttcaaccc
     6421 tattttacag cgacagcatc taatatcggt tatagttggt ggagtcatga tatcggtgga
     6481 catatgttgg gggattatga cgaagagcta caaactagat ggctacagtt tggtgttttt
     6541 agtccgatta ctcgattaca tagttctaga agtcctttta atagtaaaga accttggttt
     6601 ttttcagaaa caacatctaa gattatgaag aaataccttc gtttgagaca tcagatgatt
     6661 ccctatctat ataccatgaa tgtaaagaca catgaggaag gtgccccatt aatcagtcca
     6721 atctattatt tctatccaga gaatgatgag agctataatg ttccaaacca atactttttt
     6781 ggaacagaac tgatggtggc tcccattgta gaaaagatgg atttgacatt ccaatctgca
     6841 aaagtagatg tatggttccc tgaaggtgaa tggtatgact ttttttcaga taaaaaatac
     6901 acaggtggtg tgaagttaag tgtttatagg gacatctcga ctacgcctgt gtttgcaaaa
     6961 agtggtgcaa tcattccctt ggttggttct gagataggta tgggtgttga tttacctgag
     7021 gttgtagatt ggtatgtatt cccagggaaa caacattctt ttgaaatgct tgaagatcaa
     7081 aatggtcaaa gatataaaac aagattatca atcgattggg aaatgggaat ggtagagtta
     7141 gcattacaag gagattctag tatcgttcca agcaatagaa aacatagaat tcattttaaa
     7201 ggaacgaatg tgtctataat tgaattgcca aataagaatg atacagctaa atttgaatgg
     7261 aaagataata aaaggacatc tttaaatgac gaagttttta gactactaaa gacagcttct
     7321 cttccatatg aattaaaaga tagattgtta aatcaattca tcaatgcgaa aaactctcat
     7381 gacttaatga atatcttgca tcatcaggat aaggaattga gagggcgttt gttggaaatg
     7441 atatttacta gccaaaacta attgatataa ttagaaagtc atttgtttag tgtatatgaa
     7501 gattctgtat ggtattcgtt atcactggtc acattgaaaa tgtgaaataa gcacctacaa
     7561 catagacttt acaacacttc atgtttcata tcatggggtg tttttctatt taagtcaaag
     7621 ccaatcaaaa actctcacta ttcatcaggt taaaggaaac ctaatcatag tgagattgtg
     7681 aattatagta gagtttgtat cgcctcttca atttgttttg ggtctgtttt tgaagaaaag
     7741 cgttcaaaga cttgcccatc tcgaccgatg agaaacttag cgaaattcca ttcgattcgt
     7801 tttcctagtg ggccagattt ctggtcttgt aaccagacat agagagggtc tgcttcctta
     7861 ccgttgacct taatcttggc aaaacgtggg aaggtggttt gaaaatgtag gctacagaag
     7921 gcgttgattt cctctgcgct gccgggtgct tgtcccataa actgattgca agggaaatcc
     7981 aatatttcga agccttgatc ttgatagcgt tcatagagtt cttgaagtcc ctggtactgg
     8041 ggcgttaaac cacatccagt agcagtgttg acaatcaaga gaactttgcc acgatagcta
     8101 tccaagggag ttgcttggtt gttttggttc aaaacggaaa aatcataaag tgaagtcatg
     8161 agggcctctt ttctttttct acattgtaac agtttttact tttttcgtcg agtcggatgg
     8221 aagatattgt tgaagaataa gccttcaata tgatagaaac cgtttacaaa taactttaaa
     8281 aatggtatga tttaattaaa ccggtttact tagttgctat aaatctctaa tttgagattt
     8341 agttcctatt gattttacaa tatgtttatt ggagtgtata catgcaaaca aaaacaaaga
     8401 agctcattgt gagtttgtct tcacttgttt tatcaggatt tttattaaac cattatatga
     8461 cagttggagc ggaagaaacg actacgaata ccattcagca aagccagaag gaagttcagt
     8521 atcagcaaag ggatacaaaa aatttagttg aaaatggtga ttttggtcag acggaggacg
     8581 gaagcagtcc gtggacagga agcaaagctc agaggtggtc agcttgggta gaccagaaga
     8641 atagttctgc agatgcctca actcgagtca ttgaggctaa ggatggggct atcactatct
     8701 caagccctga gaaattaagg gcagcggttc accgtatggt tcctattgaa gctaagaaaa
     8761 agtataaact gcgtttcaag attaaaacag atcataaagt cgggattgcc aaagttcgta
     8821 tcattgagga aagtggtaag gacaagcgat tgtggaattc tgcaacgacg tcaggaacaa
     8881 aggactggca gaccattgaa gcagactata gcccgacttt agatgttgat aaaatcaagc
     8941 tggagttatt ctatgaaaca ggaactggga ctgtttcctt taaggatatt gagctggtag
     9001 aggtagcaga ccagctttct gaggattctc aaacagataa acagcttgag gaaaagattg
     9061 atttaccaat tggaaaaaaa catgtttttt ctcttgcgga ctatacttat aaggtagaaa
     9121 atcctgacgt tgcttcagtc aaaaatggaa ttttagaacc tcttaaggaa gggacaacca
     9181 atgtcattgt cagtaaagat ggcaaggaag tgaaaaagat tcctttgaag attctagcct
     9241 ctgttaagga tgcatacaca gaccgtttgg atgactggaa tggcatcatt gctgggaatc
     9301 aatactatga ttctaaaaat gaacagatgg ccaaattaaa ccaggaattg gaaggaaagg
     9361 tagctgatag cctatctagt atttcaagtc aggcggaccg cacctatttg tgggaaaaat
     9421 tttcaaatta taaaatgtct gcaaatctga ctgccactta tcggaaattg gaggagatgg
     9481 ccaagcaagt gaccaatcct tcttctcgtt attatcaaga tgaaactgtc gttcgaacag
     9541 tcagggattc catggaatgg atgcataaac atgtctacaa tagtgaaaag agcattgttg
     9601 ggaactggtg ggattatgaa atcggtacac ctcgtgccat caacaatacc ttgtctctga
     9661 tgaaagaata cttctctgat gaggaaatta aaaaatatac agatgtgatt gaaaaatttg
     9721 taccagatcc cgaacatttc cgaaagacga ctgataaccc attcaaggct ctaggtggaa
     9781 acttagttga tatgggaagg gtaaaagtaa tagctggttt actgcgtaag gatgatcaag
     9841 aaatttcttc taccattcgc tcgattgagc aagtgttcaa gttggtagac caaggtgaag
     9901 gtttttatca agatggatcc tatatcgacc ataccaatgt tgcctatacg ggtgcttatg
     9961 ggaatgtttt gattgatggc ctgtctcaac tgttgccagt cattcaaaag accaagaatc
    10021 caatcgataa agataaaatg caaaccatgt accactggat tgataaatcg tttgctcctt
    10081 tgctggtgaa tggagagctg atggatatga gtcgtggacg ctcgatcagt cgtgcaaata
    10141 gcgaggggca cgtggccgca gtagaagtac taagagggat tcaccgaata gcggatatgt
    10201 ctgaaggaga aaccaaacaa cgtttgcaga gtcttgtgaa gaccattgtt caatcggata
    10261 gttattatga tgtctttaag aatttgaaga cttataagga tatcagtttg atgcaatcct
    10321 tgttaagtga tgcaggagtc gcaagtgttc caagaacaag ttacctatct gcctttaaca
    10381 agatggataa aacagccatg tacaatgcag agaaagggtt tggatttggc ttgtcactct
    10441 tttccagtcg taccttgaat tacgaacaca tgaacaagga aaataaacat ggttggtata
    10501 cgagtgatgg gatgttctat ctttacaatg gcgatttgag tcactatagc gatggctact
    10561 ggccaacagt taatccatat aagatgcctg gtacaacaga gacggatgct aagagagcgg
    10621 atagcgatac aggtaaagtt ctaccgtctg ctttcgttgg aacgagcaaa ctagatgatg
    10681 ccaatgcgac agcaaccatg gatttcacca actggaatca aacattgact gctcataaga
    10741 gctggtttat gctgaaggat aagatcgcct ttttaggaag caatatccaa aacacttcaa
    10801 cagatactgc tgcaactaca attgaccaga gaaaactgga atcaagtaat ccatataaag
    10861 tctatgtcaa tgataaagaa gcctccctta cagaacaaga aaaggattat cctgaaaccc
    10921 aaagtgtctt tttagaatcg tccgattcga aaaagaatat tggttacttt ttctttaaga
    10981 agagttcaat cagtatgagt aaggctttgc aaaagggagc ctggaaggat atcaatgaag
    11041 gacagtcaga caaggaagtt gaaaatgaat ttcttacgat tagtcaggct cataagcaaa
    11101 atggagattc ttatggctat atgctcatcc ctaacgtggg tcgtgccacc ttcaatcaaa
    11161 tgataaaaga gttagaaagt agcctcatcg aaaataacga aacccttcag tctgtttatg
    11221 atgccaaaca aggagtttgg ggcattgtga aatatgatga ttctgtctct actatttcca
    11281 accaattcca agttttgaaa cgtggagtct ataccattcg aaaagaaggg gatgaatata
    11341 agattgccta ctataatcct gaaacccagg aatcagctcc agatcaggaa gtctttaaaa
    11401 agctagagca agcagctcag ccacaagtac agaattcaaa agaaaaggaa aaatctgaag
    11461 aggaaaagaa ccattcggat caaaagaatc tccctcagac aggagaaggt cagtcaatct
    11521 tggcaagtct agggttcttg ctacttgggg cgttttattt attccgtaga ggaaagaaca
    11581 actaatttgt tcatcatcta gatgaattac atgaaactgt ggaaaataga aaaaatccga
    11641 agaaggccaa atatcttcgg atttttcttt taaaaaagat aagttgatac ttatcttttt
    11701 tacttcatta tgtgactata gcgttttgaa actagaatag gacgtcataa ctgctaaaag
    11761 atttctataa attcatttga ttttcctaat caatttgttc gtatcctatt tcactccact
    11821 atattagtcc gtctcgctcc gtgaggtgcg agacaaaaca accacccgct atgcgggtgc
    11881 gcgtcgaagg ttataccaaa aaaactccaa acgcgataca ataaaggtgt tcaatccact
    11941 tgtaaagcga aaggagaaaa aatatggcac aaaaggctca tagtttatct cacacaaagt
    12001 ggaggtgttc tatcacattg tgttcacccc taagtataga cgaaaagtca tctataatca
    12061 atatagaagt agtttaggcg aaatatttca tcgcttgtgt agttataaag gtgttgaaat
    12121 gatcgagggt cacttaatgc cagaccatgt acacatgtta gtcagtattc cactaaggct
    12181 aagtgtttcg agtttcatgg gttatttaaa aggcaaaagt gcactcatga tgtttgacaa
    12241 acacgccaat ctcaagtaca agtttgggaa tcggcatttc tgggcggaag gttattatgt
    12301 aagtccagta gggcttaatg aagccacaat taagaaatat agtcaagatt aaagaaatta
    12361 tccagtggat gatttcttca cgagtatgaa aatttgagaa ctagtaaagt atgatatata
    12421 gtaaaatgaa ataagaacag gacaaaatcg atcaggacag tcaaatcgat ttttaacaat
    12481 gttttagaag tagaggtgta ctattccagt ttcaatctac tatagcacta gataaattga
    12541 gtgtaaaaga atatgaggat ccctttaggg atagtggtaa gtaataccaa agtctcttaa
    12601 agaggcaagt gacgagtcaa gagcaataag gcttgaacaa cgtgaaagcc agcgtcttta
    12661 ggcgctggct gatgatttgg gcttatagct ctgagataaa ccacccgtta gacgggtagt
    12721 tatgatttta tctgagtgta acatactgtt gggcaatctc gctgatgcgg tcaaagttgc
    12781 cttgggaagc gagtttattg agttcgccac caattccaac ggcatctgca ccagcagcga
    12841 accattgagg gatgttgttt aggccgactc ctccggttac cattacggaa acttgtggga
    12901 tcggtgcctt gactgcagag atatatgctg gactgagagt actacctggg aagagtttga
    12961 tgatttcact accggcttca agtgcagtcg tgatctctgt gagggtaata cagcctggaa
    13021 tgtacggtgt gctgtagaga ttgcacattt tcgcagtttc agcatggaaa gatggagaaa
    13081 caacgtaatt tgctccagct agaatggcat ctctagcagt tacggcatca agcacagtac
    13141 ctgcaccgat acaaacactc tgatcgtcct gatacaagtc tacaagttcc ttgatgattt
    13201 gtcctgcata ctgattggta taggcgattt caatagcttt gataccgccc ttgatacaag
    13261 caatcgaggc ttgtagtcct tcttcctttg tatttcctcg aatgacagcg acaattttct
    13321 gtttttttag ttcaataatc gtatctgatt tggtcatgta attctcctaa cgaatgatat
    13381 cttgtgcatt tgccagtaaa ttttcaatac tagttgcgga agtggagaga tggtctcctg
    13441 gaagagtgca tttgagagtt gcgctcgcaa ctgcaaagtc aatggtagtt tttagggagg
    13501 aatgatggag tagttggtaa agggcaccag atataaaggc atccccgcta ccaattcgtt
    13561 gatagactgc agtttttagt tggacagact cttcaaatcg ttcttccaga gcataggctt
    13621 gatagacatt tttgtcttgc tcatcactag atcggagggt atggaaaata gccttgaaac
    13681 cataggtttc ttttaaaagt cgcatgcgat tttccacctc ttctaggcta gcactgtctc
    13741 ttggaaacat ctctagattt tggtcatcaa tcatgagagg atcaataccg aagcaatagt
    13801 cagtaaaacg tgcaaactta gaaaattcat acttggcttc tagggctgaa atcatctttg
    13861 ttctcagatt gagatccatt gaaacgacaa ttcctcggcg cttggcttct tccaagagta
    13921 ggagaaggat cgcacggacc tcttgaccga tagctatggt gattccacta aaatgaaaat
    13981 ggctaatccc ctgaaagaga gaatccatat ctagcatgtt tggccgaatc tggctgatac
    14041 tcgtatgctt acgatcgtag aaaacttcac tttgacgaca accaaagccg ttctccaaat
    14101 agtagaggcc gattcgatcg ccaagccgac agattgaact ggtatcgatt tggtgctgtt
    14161 tcaagaatgt gagaaaacga tctccaatct cgttggcagg gagtgcggta aagactttcg
    14221 ttgagatacc cagggcttgc aaattacaag cgatgttaat ttctgatccg ccaaaataag
    14281 tcgaactggc aacatgatcg ccgatactgg tggcatctaa tggtgagatt cgaattaatg
    14341 gttcgccaaa cagtaatatt ttcgtcatcc attagttcct ttctggttta gaatagcttt
    14401 acttggctaa tacttctttc aaataagcag cgacttcatc atcttggcag ttttcaaaga
    14461 agtattcttg gaagtatttg ccagagatgg tgtctttgag gaagtcttgg tcgattgttt
    14521 taaggatggt catcaaatca ttgtgggtga tttgtttcac ctcgtttaag atacgagcgt
    14581 tgcgttgttc agggattaca cgttctcttg ggtagccacc gcccatttct tcagcaaata
    14641 agcgttcaaa catcaatttg agggtcagtt ctgcccccca gccaaatcct ttggcataag
    14701 ggatagacaa ggcgttacca ccattgattt gagaataaag gtaagcgtca gttgggtcca
    14761 ctgctagacc acagacaaca ccagggaagc tgtttaaagc aagcatagcc cctacacccg
    14821 taccacagcc ggtaacaaca aagtcaactg cctttgtatt taaaaggatg gcagccatta
    14881 gtccgttctg cacataagtt aattgacttt ctccttcttc tccacgcata ccatagttaa
    14941 ataattggta gtctttttta tctgtcgctt cttttagact atcgtaaata atgtgattct
    15001 tgctagcttg actattttca ttgattaatg cgattttcat aagatcttct ttctattttt
    15061 actcaggttg ttttccgatg taggctaaga taccgccatc tacatatagg atgtggccat
    15121 tgacaaaatt gctggcatca ctagcgagaa agacagcagg gcccatcaaa tcttcaggat
    15181 ttccccaacg tgcagcaggt gtttttgcaa tgatgaactg gtcaaatggg tggcgagaac
    15241 catcttcttg caactcacga agaggtgctg tttgaggagt ggcaatataa cctggtccaa
    15301 ttccgttaca ttggatattg gctccaccgt attcagacgc aatgttgcgg gtcaacattt
    15361 tcaagccccc tttagcagca gcataagcgc taactgtttc acgtcccagt tcgctcatca
    15421 tcgaacaaat attgataatc tttccatgcc ctttctttat catagaagga ataactgcct
    15481 ttgaaacgat aaatggtgcg tttaagtcaa tatcgatgac cttacggaaa tcagcggcgc
    15541 tcatttcgca cattggaact cggcggataa taccagcgtt attaacgagg atgtcaatga
    15601 caccaacctc ttgttcgatt tgcttgacca tggcttggat accgtcctcg tctgtcacgt
    15661 cacagacata tccatgggct tcgatgccaa cttcacgata agcttcaatc cctttattga
    15721 ccagatcttg attgatatcg ttaaagacaa tagtagcgcc ggcttcagcg taggatttgg
    15781 caatagcaaa tccaattcca taagaagcgc cggtgatgag agcaattttt ccttttaaag
    15841 aaaactgctc aattgagaat gatgtatttg tcatttgata cttcctttca aatttgttaa
    15901 gacttctcta taatcaaatt atattctagt aaaccggttt tgtcaataaa taaatatttt
    15961 tatttataaa aagatttatt ttccttaaaa atggaatatt ttgaaatttc tgtctattaa
    16021 aatgattaaa aagataatga aagcgctaat atttttttaa aaaaactatt gacaagataa
    16081 aaataaagga ttacaatggg gaatataaag taaaccggta aacctaaaca agaaaggaga
    16141 aaagatgaaa attgtacttg tagggcatgg acattttgct acagggattt atagttcttt
    16201 acaattgatt gcaggcaatc aagaaaatgt ggaggcgatt gactttgtgg aaggaatgtc
    16261 agcagatgaa ctcaagcaaa aaatcttact tgcaatttca aatgaagaag aagttttaat
    16321 cctaagtgat ctcttgggag gatcgccatt caaggtttct tctaccataa tgggagaaaa
    16381 tccagccaaa acaatgaatg ttctctcggg tttgaactta gccatgttaa tggaagcagt
    16441 ctttgctaga atggctcata gctttgatga ggttgttaat aaatcagtag tggcggccca
    16501 gggcggagtc gtaaatggta aagaattgtt ttcaacggat gcagaggaag aggaagaaga
    16561 tttcgaatcg ggtatttaaa gggtaaaaga atgataaaaa aggttacgat tgaaaaaata
    16621 aaatcgcctg agcgcttctt agaagtacca cttctgacga aagaagaagt cggccaggca
    16681 atcgataagg ttattcggca gttagaactc aaccttgact atttcaagga agatttcccg
    16741 acgccagcta cctttgataa tgtctatcca atcatggata acacggaatg gaccaatggt
    16801 ttctggacag gagaactgtg gttggcttat gaatacagtc aacaggatgc atttaaaaac
    16861 atcgctcata aaaatgttct ttctttcctg gatcgtgtca ataagagagt agaattggct
    16921 caccatgatc tcggcttctt gtacacaccg tcttgtatgg ctgaatataa gataaatgga
    16981 gatggagagg ctagagaagc agccttgaaa gctgcagata agttgattga acgctatcaa
    17041 gaaaaaggtg gttttattca agcttgggga gacttgggca agaaagagca ttaccgtttg
    17101 attatcgatt gcttgctcaa tatccaactc ttattctttg cttatcaaga aacaggcgat
    17161 caaaaatact acgatattgc agaaagccat ttctatgctt cagctaataa tgtaatccgt
    17221 gatgacgctt cgtccttcca caccttctat tttgatcctg agacaggtca accctttaaa
    17281 ggtgtaacga gacaagggta tagtgatgat tcatgctggg cacgtggtca gtcatgggga
    17341 gtttatggta ttcctttgac ttatcgtcac ttaaaagacg agtcctgctt tgacttgttt
    17401 aagggtgtga ccaattattt cttgaatcgt ctaccaaaag atcatgtgtc ctattgggat
    17461 ttgattttta atgatggtag tgatcaatca cgagattctt cagcaacagc tatcgccgtc
    17521 tgtgggattc atgaaatgct aaaacatctc ccagaggtgg atgctgacaa agatatttat
    17581 aaacatgcta tgcatgccat gcttcgttcc ttgatcgaac attatgcaaa tgatcaattt
    17641 acccctggtg ggacaagtct cctccacggt gtgtactcat ggcattcagg taaaggagtg
    17701 gatgaaggca atatctgggg tgactactat tacctagaag cccttatccg tttctacaaa
    17761 gactggaacc tatattggta ggaggagaaa tatgacaatg ccaaatatta tgatgacccg
    17821 tatcgatgaa cggttgattc atggacaagg acaactttgg gtaaaatacc taggttgtaa
    17881 tacggtcatt gttgccaatg acgaagtaag cacggacaag atgcaacaaa ctctgatgaa
    17941 aacagttgtg ccagactcag ttgccatgcg tttcttccct ttgcaaaagg tgattgatat
    18001 cattcacaag gctaatcctg ctcaaacgat ctttatcgtt gtaaaggatg tgaaggacgc
    18061 tttaaccttg gtagaaggtg gtgtccctat caaagaaatc aatattggga acattcacaa
    18121 tgctactggt aaagagcaag tgacacgctc catcttcctg ggtgaagagg acaaggcggc
    18181 cctcaaggaa ttgaaccaaa ctcatcaagt aacatttaat acgaaaacaa ctccaacagg
    18241 aaatgatgga gctgttcaag tcaacattat ggactatatt taaaagagga gatcgttatg
    18301 tcgattaatg tatttcaagc gattttaatt ggattatgga cagctttctg ttttagtgga
    18361 atgctgttag gaatttacac caatagatgt attgttctgt catttggtgt cggaattatt
    18421 ctaggtgatc tgcctactgc tcttgcaatg ggagctattg gtgaattggc ttatatggga
    18481 ttcggtgttg gtgctggagg tactgttcca ccaaacccaa tcggacctgg tatctttggt
    18541 accttgatgg ctatcactag tgctggtaaa gtcagtccag aagcggctct tgccctctct
    18601 actccgattg ctgtggcgat tcaattctta caaactttcg cctacactgt acgtgctggt
    18661 gcgcctgaaa cggcgatgaa gcacttgaaa aaccataatt tgaagaaatt caagttcact
    18721 ctaaatgcaa caatttggtt gtttgccttt attggattta ccttgggttg cttgggtgcc
    18781 ctttcaatgg ataccttgtt gaaactcgta gactacattc caccggtatt gcttacaggt
    18841 ttgacagttg ctggtaaaat gctcccagct atcggttttg cgatgatctt gtcagtgatg
    18901 gctaagaaag agttgattcc ctttgtcttg ttgggatatg tttgtgcagc ttatctaaac
    18961 atcccaacaa ttggtattgc aattgtaggt actatctttg ctttgattga attttataac
    19021 aagccaaaaa cagcggatca tgtggtagag gaggaagcac acgatgactg gatctaacaa
    19081 attaacaaaa cgtgattatc ttaaaacgtc tttgcgggca ttcttttgtc aaaatggatt
    19141 taactatagt aactatcaag ggttgggata tgccaatgtg atgtatcctg ctttgaaaaa
    19201 acactatgga gaggatcagg aaggtttcta ccaagccttg gaagaaaact gtgaattcta
    19261 taataccaac ccacacttcc tgccttttat taccagcttg catcttgtaa tgttggaaaa
    19321 tggccgtccg gcaaaagaaa cacgtagtat caagatggcc ttgatgggac cattggcagg
    19381 tattggggat tctctttctc aattctgttt agctccattg ttctcaacca tcgcagcttc
    19441 gtttgctcaa gaaggcttgg ttgtcggtcc aatcttgttc ttccttgcga tgaatacgat
    19501 tttaacagcg attaaattgt caactggtct gtatggatac aaactaggaa caactgtgat
    19561 tgataaacta agcgaacaga tggcaacgat ttctcgtatt gccaatatta tcggtgtaac
    19621 cgtaattgct ggtttggcag cgacatctgt taagattatg gtgccgatta cctttgctgc
    19681 aggggaagtt aaagcagacg ctaaacaaag tatcgtaagt attcagggaa tgcttgataa
    19741 ggttgctcca gctcttctac cagccctatt tacactttta gtttactact tgatcaaaga
    19801 aaagaaatgg acaacatata aactcgttat tttaacagtt atcatcggaa ttatcggaag
    19861 ctggcttaag attatagctt aatggataca acattgtttt atggaatagt gattgtcttg
    19921 gcagtgagtc cccttttact gtcaagcttt cattctattc gtcagcaaaa gttgcttcgc
    19981 aaacagatgg agcaacgaca agagtattta gcttctttaa catctggtga tgaagtgttg
    20041 ttattgtctg gaattcatgg aaaaatcatt tctatccaag atgacttggt ctccttgcag
    20101 attgcaaaag gtgtggtcat ctatgtagaa aaggaaagtg taatgggaaa gacaaaagaa
    20161 ctgcttttta agtagttctt tttctggtaa tagataatga aagaagaaag aagacaattt
    20221 tttgaaagaa tcgatggaaa ccaatgtcgt gattatatct tgtcgcactg ttcaaaagac
    20281 tatgagaaag tcaagagttc ccttgaacgc ttgatggaca atcgttttat gtttgatagt
    20341 ccttgggata tggagccttg ttcaaaaatc catcaaatcc agccgatggt atgggatcaa
    20401 gtatttgaag atgatccaga atgggcttat atgctcaatc gacaagaata tctcttgcag
    20461 tttatgatag ggtatgtggt agaaggagat aaggactata ttcaaaagtg caagttcttt
    20521 ctatttgatt ggattgagca ggtgagagaa ttttctcctc aatccttgat gactagaacc
    20581 ttggatacgg gtattcgttc ctttacttgg ttgaaactac tcttgcttct cttgaaattt
    20641 gacttgctag aggagaaaga actagagaaa attttggtca gtctagaaaa gcagattgac
    20701 tttatgaaaa gctactatcg cgccaagtac acccttagta actgggggat tttacaaaca
    20761 attccgatgc ttgctatcta tcatttcttt tcagataaga tggacctaga agaagcttac
    20821 cattttgctt cagaggagtt gaaacagcaa attgagacac agattttagg agatggaagc
    20881 cagtttgaac agtcgattct ctatcatgta gaggtttata aagccttgct ggatttgtgt
    20941 ctcttgcttc cagacttgca agatagttac caagagttgc tggaaaagat ggcgacctat
    21001 attcaaatga tgacaggctt agatggacgg actttggctt ttggtgatag cgattctaca
    21061 gaaacgacag aaatgttgag cctgtctgct gtggttttga acaaggaaga ccttcttaac
    21121 ggtctggatg ttaaagttga tttgcttagc ctcttgttcc tggggcgaga aaaggtcaag
    21181 cgactgcagg aatttgaaag gagagcttgg cagcctaagt ccatgatctt tgaagactct
    21241 ggacatgtct gcattaagga tgaacatcgt tatctatttt tcaaaaatgg tccgctagga
    21301 agtgcccata gccatagtga cgagaatagt ttttgcttac agtatcaagg ccaacctatt
    21361 ttcatagatg ctgggcgtta ttcttatcgg gagatatatg aacgttatct cttaaagagt
    21421 gcttggagtc attcgacctg cattgtagat gggaaagctc cggaaagaat cacgggatcc
    21481 tgggaatatg aatactatcc tcactccctg ttttgtcacc ataaagaaag ggagggagtg
    21541 cattatattg agggggctta ttggtcagca gaacctgatt tgccttatct tcacaagaga
    21601 aaaatcctca tgttggtaga ggatgtctgg ctcttggtag atgacatcag gtgtcaaggt
    21661 cagcatgagg cgttgattca gtttatcctt gacaaggatg tgacctatca agatgggaaa
    21721 atcaatcagt tgagactatg gagtgaagtt gattttgatt tggaagatac catcatttct
    21781 cctaaataca atgagcttga aagaagtagc aaactcacca agcgccaatt ctttgagaat
    21841 cagatgctgg attataccat cattgcgcat gagagttttg aaatcatccg tcattctgtc
    21901 taccagacag atgatcgtga agtggaaaat gctctggctt ttgaagtgaa aaatgacgaa
    21961 acagacaagc tgattctgtt attaagcgag gatattggtg taggtgaaaa attgtgcctc
    22021 gttgacggaa caaaaatgcg tggaaaatgt ctagtatatg ataaaataaa tgagagaatg
    22081 attcgcttgc agtgctagaa ataggcattt tgaatagtga acatgttata ataagtatta
    22141 gtaggaggtg ttttagattg gagaagaaac tgaccataaa agacattgcg gaaatggctc
    22201 agacctcgaa aacaaccgtg tcattttacc taaacgggaa atatgaaaaa atgtcccaag
    22261 agacacgtga aaagattgaa aaagttattc atgaaacaaa ttacaaaccg agcattgttg
    22321 cgcgtagctt aaactccaaa cgaacaaaat taatcggtgt tttgatcggt gatattacca
    22381 acagtttctc aaaccaaatt gttaagggaa ttgaggatat cgccagccag aatggctacc
    22441 aggtaatgat aggaaatagt aattacagcc aagagagtga ggaccggtat attgaaagca
    22501 tgcttctctt gggagtagac ggctttatta ttcagccgac ctctaatttc cgaaaatatt
    22561 ctcgtatcat cgatgagaaa aagaagaaaa tggtcttttt tgatagtcag ctctatgaac
    22621 accggactag ctgggttaaa accaataact atgatgccgt ttatgacatg acccagtcct
    22681 gtatcgaaaa aggttatgag cattttctct tgattacagc ggatacgagt cgtttgagta
    22741 ctcggattga gcgggcaagt ggttttgtgg atgctttaac agatgctaat atgcgtcacg
    22801 ccagtctaac cattgaagat aagcatacga atttggaaca aattaaagaa tttttacaaa
    22861 aagaaatcga tcccgatgaa aaaactctgg tatttatccc taactgttgg gccctacctc
    22921 tagtctttac cgttatcaaa gagttgaatt ataacttgcc gcaagttggg ttgattggtt
    22981 ttgacaatac ggagtggact tgcttttctt ctccaagtgt ttcgacgctg gttcagccct
    23041 cctttgagga aggacaacag gctacaaaga ttttgattga ccagattgaa ggccgcaatc
    23101 aagaagaaag gcaacaagtc ttggattgta gtgtgaattg gaaagagtcg actttctaaa
    23161 atgaaggaaa atgacttgca atctctgtta agaaataaaa taatcccacc tagaacaagc
    23221 taggtgggat tatttgccta tgaaatgaga aattatggga gcaagctcct aaatcaactg
    23281 tttttgatct acttctttaa ctacttgata aaagttatag aagtaggcca aacttgaaat
    23341 gatggttacg actaggaata ttgaaaattt ccattggaca gggttggtta aaagttgtgg
    23401 aaaggatatg aggagaaaga agagggctgc gttgaggaca ggtatccgtt ttgattgtat
    23461 tttctcaagt cctttattga gcgcaggaag aaagaggagt aggagtagta aaactgtatg
    23521 agaaacagct cctgaaataa gggcaaagaa aaggaaaata ctgataaaaa catgaatgat
    23581 cagtagtcta gctagtgatt tcataaggta cctcctaatc ctggtctttt ttagctcttg
    23641 caatacgaag tgagtcgaca atatgtatca tcactccgaa aaagaaagct cccagtatag
    23701 ttttaaaaat atgttttgta tttagaagag aactgataaa atttggattt tcacttgtta
    23761 gggtatcaat gagtggaatt ataaaaaata tcactgttcc ataaatcgaa cctgctttca
    23821 gaccaggata acgtaactgt ctcttttctt ttttcatgag tttcctccta atcctcatct
    23881 tgatttttct tagtttttgc aatgcgacgg gagatgagga actgtatgct cgctccgaag
    23941 aaaatagaac cgagaatgct tgatacacca tttcttatag tgagaagaga atgaaaatag
    24001 tcctgacctt catctatgag tatactgaga agaggagtta taaaaaacat ccatagacca
    24061 aagaacaaac ctgctttcag acctgggtag tgtagttgct tgctttcttt ctcattcagc
    24121 atatctggtt caatgactgt gatgcctgtt tttttcattt ggtaggtgac atagccagaa
    24181 gcgatgaggg caatcactaa aatcagaggg ggatagatta gagccacttc ttgagggtat
    24241 ttataggcta gaaggagtgg aataatattt ccgaaaatca tcagataaaa gaggacgata
    24301 aagacttggt tcccaatact atcggcctca cgccgtttgt attcgtcaag gggaccagaa
    24361 ataccgtatg tgcgtttgat cagtttttca gtgaaggttt cttttttcat gagtttgctc
    24421 cttttttaaa aatcttcctc ccaaaagaga ctgttgaggt cagtttggag gctgcgggcg
    24481 agattgagac agagttccaa ggttggattg tacttgtcgt tttcaatcat attgatagtc
    24541 tgtctcgaga caccgatatc cttggcgagt tcgagctggg aaatacccaa ttccttgcga
    24601 aattctttca cacgattcat ctggtctcct ttctgattta tgtcgtatat atttgactat
    24661 attatagtct tttaaacata aagtgtcaag tatttttgac atattttttg aagaaatagt
    24721 agtctccttg tcctatttgt ctgacaagtg caagctggtc ggatttgtgg taaaatagat
    24781 aagatatgac aaaagaattt catcatgtaa cggtcttact ccacgaaacg attgatatgc
    24841 ttgacgtaaa acctgacggt atctacgttg atgcgacttt gggtggagca ggccatagcg
    24901 agtatttatt aagtaaatta agtgaaaaag gccatctcta tgcctttgac caggatcaga
    24961 atgccattga caatgcgcaa aaacgcttgg caccttacat tgagaaggga atggtgacct
    25021 ttatcaagga caacttccgt catttacagg cacgtttgcg cgaagctggt gttcaggaaa
    25081 ttgatggaat ttgttatgac ttgggagtgt ctagtcctca attggaccag cgtgagcgtg
    25141 gtttttctta taaaaaggat gcgccactgg acatgcggat gaatcaggat gctagtctga
    25201 cagcctatga agtggtgaac aattatgact atcatgactt ggttcgtatt ttcttcaagt
    25261 atggagagga taaattctct aaacagattg cgcgtaagat tgagcaagcg cgtgaagtga
    25321 agccgattga gacaacgact gagttagcag agattatcaa gttggtcaaa cctgccaagg
    25381 aactcaagaa gaagggtcat cctgctaagc agattttcca ggctattcga attgaagtca
    25441 atgatgaact gggggcggca gatgagtcca tccagcaggc tatggatatg ttggctctgg
    25501 atggtagaat ttcagtgatt acctttcatt ccttagaaga ccgcttgacc aagcaattgt
    25561 tcaaggaagc ttcaacagtt gaagttccaa aaggcttgcc tttcatccca gatgatctca
    25621 agcccaagat ggaattggtg tcccgtaagc caatcttgcc aagtgcggaa gagttagaag
    25681 ccaataaccg ctcgcactca gccaagttgc gcgtggccag aaaaattcac aagtaagagg
    25741 gaaaaagatg gcagaaaaaa tggaaaaaac aggtcaaata ctacagatgc aacttaaacg
    25801 gttttcgcgt gtggaaaaag ctttttactt ttccattgct gtaaccactc ttattgtagc
    25861 cattagtatt atttttatgc agaccaagct cttgcaagtg cagaatgatt tgacaaaaat
    25921 caatgcgcag atagaggaaa agaaaaccga attggacgat gccaagcaag aggtcaatga
    25981 actattacgt gcagaacgtt tgaaagaaat tgccaattca cacgatttgc aattaaacaa
    26041 tgaaaatatt agaatagcgg agtaagatat gaagtggaca aaaagagtaa tccgttatgc
    26101 gaccaaaaat cggaaatcgc cggctgaaaa cagacgcaga gttggaaaaa gtctgagttt
    26161 attatctgtc tttgtttttg ccattttttt agtcaatttt gcggtcatta ttgggacagg
    26221 cactcgcttt ggaacggatt tagcgaagga agctaagaag gttcatcaaa ctacccgtac
    26281 agttcctgcc aaacgtggga ctatttatga ccgaaatgga gtcccgattg ctgaggatgc
    26341 aacctcctat aatgtctatg cggtcattga tgagaactat aagtcagcaa cgggtaagat
    26401 tctttacgta gaaaaaacac aatttaacaa ggttgcagag gtctttcata agtatctgga
    26461 catggaagaa tcctatgtaa gagagcaact ctcgcaacct aatctcaagc aagtttcctt
    26521 tggagcaaag ggaaatggga ttacctatgc caatatgatg tctatcaaaa aagaattgga
    26581 agctgcagag gtcaagggga ttgattttac aaccagtccc aatcgtagtt acccaaacgg
    26641 acaatttgct tctagtttta tcggcctagc tcagctccat gaaaatgaag atggaagcaa
    26701 gagcttgctg ggaacctctg gaatggagag ttccttgaac agtattcttg cagggacaga
    26761 cggcattatt acctatgaaa aggatcgtct gggtaatatt gtacccggaa cagaacaagt
    26821 ttcccaacga acgatggacg gtaaggatgt ttatacaacc atttccagcc ccctccagtc
    26881 ctttatggaa acccagatgg atgcttttca agagaaggta aaaggaaagt acatgacagc
    26941 gactttggtc agtgctaaaa caggggaaat tctggcaaca acgcaacggc cgacctttga
    27001 tgcagataca aaagaaggca ttacagagga ctttgtttgg cgtgatatcc tttaccaaag
    27061 taactatgag ccaggttcca ctatgaaagt gatgatgttg gctgctgcta ttgataataa
    27121 tacctttcca ggaggagaag tctttaatag tagtgagtta aaaattgcag atgccacgat
    27181 tcgagattgg gacgttaatg aaggattgac tggtggcaga atgatgactt tttctcaagg
    27241 ttttgcacac tcaagtaacg ttgggatgac cctccttgag caaaagatgg gagatgctac
    27301 ctggcttgat tatcttaatc gttttaaatt tggagttccg acccgtttcg gtttgacgga
    27361 tgagtatgct ggtcagcttc ctgcggataa tattgtcaac attgcgcaaa gctcatttgg
    27421 acaagggatt tcagtgaccc agacgcaaat gattcgtgcc tttacagcta ttgctaatga
    27481 cggtgtcatg ctggagccta aatttattag tgccatttat gatccaaatg atcaaactgc
    27541 tcggaaatct caaaaagaaa ttgtgggaaa tcctgtttct aaagatgcag ctagtctaac
    27601 tcggactaac atggttttgg tagggacgga tccggtttat ggaaccatgt ataaccacag
    27661 cacaggcaag ccaactgtaa ctgttcctgg gcaaaatgta gccctcaagt ctggtacggc
    27721 tcagattgct gacgagaaaa atggtggtta tctagtcggg ttaaccgact atattttctc
    27781 ggctgtatcg atgagtccgg ctgaaaatcc tgattttatc ttgtatgtga cggtccaaca
    27841 acctgaacat tattcaggtg ttcagttggg agaatttgcc aatcctatct tggagcgggc
    27901 ttcagctatg aaagactctc tcaatcttca aacaacagct aaggctttgg agcaagtaag
    27961 tcaacaaagt ccttatccta tgcccagtgt caaggatatt tcacctggtg atttagcaga
    28021 agaattgcgt cgcaatcttg tacaacccat cgttgtggga acaggaacga agattaaaaa
    28081 cagttctgct gaagaaggga agaatcttgc cccgaatcag caagtcctca tcttatctga
    28141 taaagcagag gaggttccag atatgtatgg ttggacaaag gagactgctg agacccttgc
    28201 taagtggctc aatatagaac ttgaatttca aggctcgggc tctactgtgc agaagcaaga
    28261 tgttcgtgct aacacagcta tcaaggacat taaaaaaatt acattaactt taggagacta
    28321 atatgtttat ttccatcagt gctggaattg tgacattttt actaacttta gtaggaattc
    28381 cggcctttat ccaattttat agaaaggcgc aaattacagg ccagcagatg catgaggatg
    28441 tcaaacagca tcaggcaaaa gctgggactc ctacaatggg aggtttggtt ttcttgatta
    28501 cttctgtttt ggttgctttc tttttcgccc tatttagtag ccaattcagc aataatatgg
    28561 gaatgatttt gttcatcttg gtcttgtatg gcttggtcgg atttttagat gactttctca
    28621 aggtctttcg taaaatcaat gaggggctta atcctaagca aaaattagct cttcagcttc
    28681 taggtggagt tatcttctat cttttctatg agcgcggtgg cgatatgctt tctgtctttg
    28741 gttatcaagt gcatctaggg attttctata ttgtcttcgc tcttttctgg ctagtcggtt
    28801 tttcaaacgc agtaaacttg acagacggtg ttgacggttt agctagtatt tccgttgtga
    28861 ttagtttgtc tgcctatgga gttattgcct atgtgcaagg tcagatggat attcttctag
    28921 tgattcttgc catgattggt ggtttgctca gttttttcat ctttaaccat aagcctgcta
    28981 aggtctttat gggtgatgtg ggaagtttgg ccctaggtgg gatgctggca gctatctcta
    29041 tggctctcca ccaagaatgg actctcttga ttatcggaat tgtatatgtt tttgaaacaa
    29101 cttctgttat gatgcaagtc agttatttca aactgacagg tggtaaacgt attttccgta
    29161 tgacgcctgt acatcaccat tttgagcttg ggggattgtc tggtaaagga aatccttgga
    29221 gcgagtggaa ggttgacttc ttcttttggg gagttgggct tctagcaagt ctcctgaccc
    29281 ttgcaatttt gtatttgatg taagaatggc accctgatgt ttcagggtgt ttttgtgttt
    29341 aaatacacaa tgaaaatcaa agaacaaact agaaagctaa ctttaggctg ctcaaaatat
    29401 agtagattga aactagaata gtacacctct acttctaaaa catttttaga aatcgatttg
    29461 actgtcctga ttgatttgtc ctgttcttat ttcattttat tatacagttt tgagatggtt
    29521 gatagaactg acgaagtcag ctcaaaacac ggttttgagg ttgtagataa ggagaagctg
    29581 atgtagtttg aagaggtttt cgaagagtgt aaaaaaatat tggtcagtta aagtcaaaac
    29641 ccttgacctt ttctgaccaa tgtagtatat tatgaacgta aggtaaatga aagccttact
    29701 agaacactta tttaaagtaa aatagaaaga ggtgggtcta tgtttcatct agaaatcttc
    29761 agaagtaaag atagtctact cctgcttgaa aaagaaaaac cagaaatagt acgtagggta
    29821 gcgatctagc tagtctaaat tttttaaaac aatggtcaaa gatagtcaat atcagtaatc
    29881 ataactaagt aaacaaaaag aggtaaagaa tatgaataac aactttaata attttaataa
    29941 catggatgat ttatttaacc aattgatggg tggtatgcga ggatacagtt ctgaaaatcg
    30001 ccgttactta attaatggac gcgaagtcac acctgaggca tttgctcact atcgtgcgac
    30061 tggtcaatta ccaggaaatg cagaaactga tgtgcaaatg ccccaacagg catcaggtat
    30121 gaaacaagac ggtgtccttg caaaactagg tcgaaactta acagcagaag cgcgtgaggg
    30181 caagttggat cctgttatcg gacgaaacaa ggaaattcaa gaaacatctg aaatcctctc
    30241 acgccgcacc aagaacaatc ctgttttggt cggagatgca ggtgttggta agacagcagt
    30301 tgtcgaaggt ctagcgcaag ccattgtgaa cggagatgtt cctgctgcta tcaagaacaa
    30361 ggaaattatt tctattgata tctcaggtct tgaggctggt actcaatacc gtggtagctt
    30421 tgaagaaaat gtccaaaact tagtcaatga agtgaaagaa gcagggaata ttatcctctt
    30481 ctttgatgaa attcaccaaa ttcttggtgc tggtagcact ggtggagaca gtggttctaa
    30541 aggacttgcg gatattctca agccagctct ctctcgtgga gaattgacag tgattggggc
    30601 aacaactcaa gacgaatacc gtaacaccat cttgaagaat gctgctcttg ctcgtcgttt
    30661 caacgaagtg aaggtcaatg ctccttcagc agagaatact tttaaaattc ttcaaggcat
    30721 tcgtgacctc tatcaacaac accacaatgt catcttgcca gacgaagtct tgaaagcagc
    30781 ggtggattat tctgttcaat acattcctca acgtagcttg ccagataagg ctattgacct
    30841 tgtcgatgta acggctgctc acttggcggc tcaacatcca gtaacagatg tgcatgctgt
    30901 tgaacgagaa atcgaaacgg aaaaagacaa gcaagaaaaa gcagttgaag cagaagattt
    30961 tgaagcagct ctaaactata aaacacgcat tgcagaattg gaaaggaaaa tcgaaaacca
    31021 cacagaagat atgaaagtga ctgcaagtgt caatgatgtg gctgaatctg tggaacgaat
    31081 gacaggtatc ccagtatcgc aaatgggagc ttcagatatc gaacgtttga aagatatggc
    31141 tcatcgcttg caagacaagg tgattggtca agataaggcc gtagaagttg tagctcgtgc
    31201 tatccgtcgt aaccgtgctg gttttgatga aggaaatcgc ccaataggca gcttcctctt
    31261 tgtaggggct actggggttg gtaagacgga gcttgctaag caattggcac tcgatatgtt
    31321 tggaacccag gatgcgatta tccgtttgga tatgtctgaa tacagtgacc gcacagctgt
    31381 ttctaagcta attggtacaa cagcaggcta tgtgggttat gatgacaata gcaatacctt
    31441 aacagaacgt gttcgtcgca atccatactc tatcattctc ttggatgaaa ttgaaaaggc
    31501 tgatcctcaa gttattaccc ttctcctcca agttctagat gatggtcgtt tgacagatgg
    31561 tcaaggaaat acagtaaact tcaagaacac tgtcattatt gcgacctcaa atgctggatt
    31621 tggctatgaa gccaacttga cagaagatgc ggataaacca gaattgatgg accgtttgaa
    31681 acccttcttc cgtccagaat tcctcaaccg ctttaatgca gtcatcgagt tctcgcactt
    31741 gactaaggaa gacctttcta agattgtaga tttgatgttg gctgaagtta accaaacctt
    31801 ggctaagaaa gacattgact tggtagttag tcaagcggct aaagattata tcacagaaga
    31861 aggttacgac gaagtcatgg gggttcgtcc tctccgtcgc gtggttgaac aagaaattcg
    31921 tgataaggtg acagacttcc acttagatca tttagatgct aaacatctgg aagcagatat
    31981 ggaagatggc gttttggtta ttcgtgagaa agcctaagat agaattttga ggataaaaaa
    32041 gaaggagcca gctgaaaaaa actggttcct tttgaggtac gacgggcatg tcgtacagtg
    32101 ggttgaaact agaatagtac acatctactt ctaaaatatt gttagaaatc gatttgactg
    32161 tcctgattga tttgtcctgt tcttatttca ttttactata tatctgaggt gtaagtcctc
    32221 ggtgggtacc tgctaccggt gctcccaata gtgattccca agcctgacta tcgtgaggta
    32281 gcggattaaa acggtctggg gatagaccgt tttaagtctg acgctggaaa taagaatcgt
    32341 cagaggaagg gatagcgaaa tcgtggctct acgaatagga acgtgataat aaggcgtata
    32401 tagcggataa ggggcctcaa actctaaagt tcaaaaaggt agtcgtagcc tatatgtgta
    32461 aatcacgaga gcaactgaat ttgtctgttc gaggatggat aaactatttc tcattgggaa
    32521 atatgaaaag tatagtcact agcatagatg agcgcttgca tactcgccta cgagtgatta
    32581 tctggaagca atggaagaaa aaatcgagac gattatgggg attgcttaag ttagg
//
LOCUS       DAVHSO010000023        29718 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.023, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000023 DAVHSO010000000
VERSION     DAVHSO010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 29718)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29718)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29718
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.023"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..4768)
                     /locus_tag="VVR18_001000"
     CDS             complement(<1..4768)
                     /locus_tag="VVR18_001000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEU6032547.1"
                     /translation="MIYLTEGNTPLNEAYNDEIVHLGNNTYQLTFRFPTSDPKWELLK
                     EETFLTADDLHGEQDFYIFEVEKQQGYIQVYANQVISLLNNYIVSSIEVDRVSGTRVL
                     SAFAGSITRANPFSFFSDIDDRHTLNIKDKNAMEVLAKGKHSILGQWGGDMVRNGYNL
                     RLLKNGGSENESLFMYKKNLSSYQHKTSTKSLKTRITFKTTVKGEGENAVDHDYMVVI
                     DSPLLGNYSQIYEDVVEVNDQDVTDEASLIEYGKQYFRTSMCDMLEDNLEISVVGQSD
                     VAVQMFDVVSFYHEWYGLDVRKKITKYTYSPMAKLLKSIGFGTFQSSLANAIGGIVND
                     AVLNESRNLHQIFEERLKKEIANADRAFDAEFSKREKTITDAIELAKAKAEEVKQELS
                     DTINQRFNSFDNGPLKEAKRKAEEALRNAGASSSLAQESKRIGLDSVARLEAFKSQTT
                     SAQTALSGDLDALKRTIANDIRPKQAQAEAEIAKQVEALSRTKNELDGASTLLAQEAK
                     RIELDSVARLEAFKSQTTSAQTALSGDLDVLKRTIANDIRPKQAQAETEIAKQVEALS
                     RTKNELAGVKSAQATYEETTTRRLSELTNLANGKASKSELTQTAEELASRIASVQAGS
                     SRNYFRNSRSRTFTTGGQAVYDYRTFIVPDFWKNSDRFKRDYVRISFDVTFPVALVND
                     MPAMVHFSAHPWYAYRNLIFKGGTVERQHFEFTIDLSSSSEDYQTNNVFIRFGTNYGF
                     PAGLQVVIENAMLSVGNYFPAYQPAYEDQEDRVSVVESTFKQRADSLAAGVNRLTEGL
                     RTKADISALNVTAENIRQSVKSLETDTQNKLNQKLSQAEFEVRAGSIRQEILNATKDK
                     ASKSELTQTAEELASKIASVHLGRRNLLKGTKELARYKPVSEYNGFKVIRTVAGATRY
                     QDSYVERTVIPTAGTEYIAIFYARASENDYPVRCHFYNPNTVVSSENSSGYKSRSSDG
                     LSIIRLSTDWQLCWVKWTQTATDQAKTVIIGRHGPQVGGKEGVWVEICAPAIFEGNLA
                     GDWSPAYEDQEDRVSAVESNFKQRADSLEAGVSRLTEGLRTKADISSLNVTAENIRQS
                     VKSLETDTQNKLNQKLSQAEFEVRAGSIRQEILNATKDKASKSELTQTAEELSSKIAS
                     VQVGGRNYIRGTKRMMLARGLWASGTFRPSGAGTAKTIDVSDSPVTGFDKAIRLTSSN
                     ARDQIGIAQDGFYISQGTYTMSCWVKGRRGQKVKLQTYWQANDNSGISPIFTLKDENW
                     TKLSFTSARNRAGVASIGYVYLVNAEVGEYLDVLAPQLEDGSLATSSKEAPEDIEGQI
                     STVESTFKQRANSLDAGVRSLTEGLRTKADISSLNVTAENIRQSVKSLETDTQNKLNQ
                     KLSQAEFEVRAGSIRQEILNATKDKANKSELTQTAEELASKIASVQASGRNLFLNSLF
                     KQDIPKTGIWTTSTYTATIDSESKYLGHKALKIIGLNPSGRDGGNPKVTYPALGQFGK
                     VIPGSTTNQDVTISFYAKANKNGIMLRSRLGNIGYKTGNVTLSTEIKRYVVHIPKGWT
                     NESKQTTNEWLFNFNQEGTIWIWMPKFEISDVDTSYS"
     gene            complement(4765..5463)
                     /locus_tag="VVR18_001001"
     CDS             complement(4765..5463)
                     /locus_tag="VVR18_001001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEU6032548.1"
                     /translation="MFYMIINGFNTSTIPHCVVTDFGQVEAAKPRVVEDANLYGANGS
                     YRVLDGGYESYERTFSFYIPKLLDVSTIVEKFQPKDNVLEFSYQLGSVFYADFIGATY
                     SPHGMHAWKLEIKLNMQPFRYQKNVAPLIFTASGNINNPGSVYSEPVIEIEGDGDISL
                     TIGRTTMHLTVRRKVTIDCRHKKQNIYNADGAVQNTLRKRGGFFELAVGNNSLVFTGS
                     VRKVTVRPNWRYIL"
     gene            complement(5463..7928)
                     /locus_tag="VVR18_001002"
     CDS             complement(5463..7928)
                     /locus_tag="VVR18_001002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PblA"
                     /protein_id="HEU6032549.1"
                     /translation="MATELGKAYVQIIPSAKGISGMIQKEMGGEVASAGVSAGESLGS
                     KMMGAVSGVIAAAGIGKAIGASINEGAALQQSLGGVETLFKDSADKVKGFANEAYKTT
                     GLSANAYMENVTGFSASLLQSLGGDTDKAAETANMAMIDMSDNANKMGTSMESIQLAY
                     QGFAKQNYTMLDNLKLGYGGTKQEMQRLLADAEKLTGVKYDINNLSDVYSAIHTIQEN
                     LDITGTTAREAATTFTGSFESMKSAAQNVLGKLSLGEDIQPALQALMETTSTFLFGNL
                     IPMIGNILKQIPILILGGIKGVFSGIFGEGLGSIMGSIVTALGSAFLAFKAFSTVSGL
                     LSGIPAVLTTIKTAVTGLFTVMSANPIGIAIAAIAGLTAGLVYFFTQTETGRQIWSSF
                     VAWIKQAWQGIADFFVNLWSGISEGASTLWDGVVTAWNAVVTFFSDLWVRIQEAASVA
                     WTAITTAVMAIVQPFIDGFMNIWNNISDGLTQIWEGIKMIFQGVWEFIKSIFLGAILI
                     IINLVIGNFNQLGADLSLIWKGIKNSISMIWEGIKTYFSGVVDVIVGYGIAIFENFST
                     TLSTIWKGLSAAGKAIFDSFAQILSNIWNTIKSVASSAWEGLKSTVLGLIDGLVQGAK
                     NAWESMKQGVRDLVSNVTSIFDGIRNIDLWSAGKAILDGFLGGLKSAWGAVTDFVGGI
                     ASWIRDHKGPIEYDRKLLIPAGNAIMQGLDRGLQDRFKDVKKSVSGMAGEISNAFSND
                     DFGLSGTPTIAKNIEASLAMPSAQIEAKDSQTVSEIAILRASMEKILTAILEKPSDTY
                     LDADKISMSVYQRQGAIYAREGM"
     gene            complement(7928..8314)
                     /locus_tag="VVR18_001003"
     CDS             complement(7928..8314)
                     /locus_tag="VVR18_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5361 domain-containing protein"
                     /protein_id="HEU6032550.1"
                     /translation="MIALDEDALICDLAETYQIYDYKQLPLNQVAVFAYGLRDDSRIK
                     QMMSDQIVPLETTLLASIVDRLSLSLWLKTKDGQKGVNRPASIAELLTKNNKEEGDKR
                     DYLVFESGEDFENYRKALLAKTGGED"
     gene            complement(8326..8601)
                     /locus_tag="VVR18_001004"
     CDS             complement(8326..8601)
                     /locus_tag="VVR18_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032551.1"
                     /translation="MEAILKGKTESGFEYKIPKKRLRNFYLMREASKMEKGDFEAAEK
                     LLNLLFGKKQAEEFLSHLDDGDDFIDTEVLFADIKSIFESNKDLKKS"
     gene            complement(8607..9215)
                     /locus_tag="VVR18_001005"
     CDS             complement(8607..9215)
                     /locus_tag="VVR18_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000205999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HEU6032552.1"
                     /translation="MTTEARRQNTESTGGKNMTTASASNVTAAKPKIGGAVSTAPAGT
                     TLPTNAKTDLDAAFKTLGYISDDGLTNANSPESKAIKAWGGQTVLSSQTEKKDTFKYK
                     LIEGLNIEVLKEVYGPDNVSGTLETGITVKANGKELPEHCLVIDTLLKNGYVKRVVIP
                     RGKVSEIGEISYKDGEPIGYELTITALPDNSENTHYEYIQGA"
     gene            complement(9231..9566)
                     /locus_tag="VVR18_001006"
     CDS             complement(9231..9566)
                     /locus_tag="VVR18_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032553.1"
                     /translation="MIELVIKKFLDGQLDVPSFFEHKPNMPESYVILEKTGSGGSDYV
                     HSATFAFQSYAPSLQKAAELNEKVKKVVEDLITVNEVSGVHHNSDYNFTDTETKQYRY
                     QAVYDINYF"
     gene            complement(9563..9799)
                     /locus_tag="VVR18_001007"
     CDS             complement(9563..9799)
                     /locus_tag="VVR18_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032554.1"
                     /translation="MSNMKFQLNSAGVSALLRSSEMQGILREKGQGIAERAGEGFELT
                     VSPGQKRANAKISTTDIKSMARNKKHNILLKAMR"
     gene            complement(9792..10130)
                     /locus_tag="VVR18_001008"
     CDS             complement(9792..10130)
                     /locus_tag="VVR18_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032555.1"
                     /translation="MTYLKGIPVILVDKVEIGNDDFGHPIHRDVEIEVQNVLVAPTSS
                     EDVINQMNLTGKKAEYTLGIPKGDTNKWENREVKFFGRKWRTIGIPQEGIESMIPLSW
                     NRKVMVEVYE"
     gene            complement(10075..10515)
                     /locus_tag="VVR18_001009"
     CDS             complement(10075..10515)
                     /locus_tag="VVR18_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000536419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage Gp19/Gp15/Gp42 family protein"
                     /protein_id="HEU6032556.1"
                     /translation="MGNFAKIEDLELLWRSLKFDERARAEALLEVVSNSLRVEAEKVG
                     KDLDDMVAESVSFASVAKSVTVDIVARTLMTSTDHEPMTQVSESALGYSFSGSYLVPG
                     GGLFIKDTELKRLGLKKKQRYGAIEIYDLPKRNPCHFSGQGGNW"
     gene            complement(10519..10731)
                     /locus_tag="VVR18_001010"
     CDS             complement(10519..10731)
                     /locus_tag="VVR18_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001240369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032557.1"
                     /translation="MALYRDTKTGVIISAESILGGDWVPVEDTAPSGADLTVAELKSS
                     LDELGIDYDKSSKKSDLVALYEENKG"
     gene            complement(10737..11633)
                     /locus_tag="VVR18_001011"
     CDS             complement(10737..11633)
                     /locus_tag="VVR18_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage major capsid protein"
                     /protein_id="HEU6032558.1"
                     /translation="MADNAMKAGTLFKPELVTELISKVQGKSVLAKLSAQTPIPFNGV
                     EQFIFNLEGNAQIVGEGEQKLGNKAKLTSKIIKPLKFVYQARITDEFQYASEEKRMNF
                     LSAYMDGFAKKIAEAFDLAALHGLEPKTMTDASFRATNSFDGVISGSTVTYDEAKIDE
                     NIEDAVQQVIARGCEVTGIALSPTAGQALAKVKVKDVVQYPEFRFGQNPDSFYGMKSD
                     INKNLTVTGGSAETDHAIVGDFQNRFKWGYAENIPMEIIEYGDPDGAGRDLKAYNEIC
                     LRAEAFIGWGILDEDAFARVKA"
     gene            complement(11639..12103)
                     /locus_tag="VVR18_001012"
     CDS             complement(11639..12103)
                     /locus_tag="VVR18_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4355 domain-containing protein"
                     /protein_id="HEU6032559.1"
                     /translation="MSEFKTIETQEELDNIVKERIRREREKFGDYDELKKRVSELESE
                     NSALKSTVEDDKQTRAGLDAQITELQGQVSNYETASLRTRIALQNGLPYDLADRLQGA
                     DEEALKADAERLAGFMRPATPPAPLRDTEPAIGDDKTTQMKQMLRELQPKGE"
     gene            complement(12186..13598)
                     /locus_tag="VVR18_001013"
     CDS             complement(12186..13598)
                     /locus_tag="VVR18_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000101482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase"
                     /protein_id="HEU6032560.1"
                     /translation="MARKKLGNQNPTQSVILKYVKKNSKAKEAVEIYERTGLSCYAWQ
                     VNLLTSIMAVDKNGLWVHQKFGYSIPRRNGKSELLYLFELWGLHNGLNILHTAHRIST
                     SHSSFEKVKCYLEKMGYVDGEDFSSIRAKGQERIELFDGGGIVQFRTRTSNGGLGEGF
                     DLLVIDEAQEYTTEQESALKYTVTDSSNPITIMCGTPPTPVSNGTVFTNYRKNCLFGK
                     GKYSGWAEWSVSEEKEIDDVDAWYNSNPSMGYHLNERKIEAELGDDKLDHNVQRLGYW
                     PEYNQKSAISETEWNELCVDSMPDLSGKLFVGVKYGQDGANVALSIAVRTVDERIFVE
                     TIDCQSVRNGNDWILDFVKRADVATIVVDGASGQKILDEELKKERMKSVILPTVKEII
                     VANSMWEQGIYQKTLCHAGQPSLKKITTNCEKRNIGSNGGFGYRSHFADMDISLMDSA
                     LLAHWACVTTKPKKKQKISY"
     gene            complement(13649..13879)
                     /locus_tag="VVR18_001014"
     CDS             complement(13649..13879)
                     /locus_tag="VVR18_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000528509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032561.1"
                     /translation="MGNTIYFLEKKSSLERGASVKEILEENLEASHDYTSVLVVSLDK
                     DGEINLGYSWDSSLQALGMLDVAKNYILNVIN"
     gene            complement(13932..14171)
                     /locus_tag="VVR18_001015"
     CDS             complement(13932..14171)
                     /locus_tag="VVR18_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000834150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032562.1"
                     /translation="MKSDYEEVNWSEYCYKENDDDKTWWVDTSWYAKGLMLITFDKKK
                     FYNLFEDYPQNMTSEEIEIFDKENPFWEDFFSDRK"
     gene            complement(14161..15552)
                     /locus_tag="VVR18_001016"
     CDS             complement(14161..15552)
                     /locus_tag="VVR18_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032563.1"
                     /translation="MVEDIVPSLLKKIKSEFEGARLDSEVLKDLLSKLQHSKASYLDA
                     NQYAIEIGEILSKALGASLTNETLPDGKMYYNIAQRVLTDVLGRNYELVSDYTEQVQK
                     NLNSEAKIGLTAQVPELNQDRIDGLVNRLASEESFDDVRWLLEEPVVNFTQSIIDDSI
                     QKNAEFQHKSGLQPEIVRKSAYHCCEWCQEVQGTYKYPRVPKDIYRRHQRCRCTVDYD
                     PKSGKVQNVWSKAWSKSDKSDKIEARKNIGIQSEVSQVRKLALQIGITSNPITKSLKK
                     LTEEEIIQAISGGDKTKGSCSSLAFAYIGNKAGYTVLDFRGGKSCVFFGSIDKINMIG
                     SLPGVKMHVAKNTNDFKAVKELLEKAENGKEYYLATGRHAAIIRKNDNLVEYLELQSK
                     FVNGFKPFDDTVLKKRFKAKKSHAVRGHKYDVDSYLIDANSLKDNPEFHNILSFLNTA
                     ESKQMKGITGYEK"
     gene            complement(15545..17008)
                     /locus_tag="VVR18_001017"
     CDS             complement(15545..17008)
                     /locus_tag="VVR18_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000172768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032564.1"
                     /translation="MTLKGMGYLRKKLANYKMGVDTRYKQYAMQYNDIDVGITIPPQI
                     RQQYRAVLGWAAKGVDSLADRLVFREFANDEFGANEIFAQNNPDVFFDSAILSALIGS
                     CCFVYISQGDDDDAPRLQVIEASNATGVLDPITGLLTEGYAVLKRDDNGYAVLEAYFT
                     SDVTWFYPKDGKPFAIGNPTGVPLLVPVIHRPDAVRPFGRSRITRAGMYYQRYAKRTL
                     ERSDVTAEFYSFPQKYVLGLSQDAEAIDTWKATVSSLLTFTKDDEGDKPNVGQFTTSS
                     MSPFTEQLRTAAAGFAGEMGLTLDDLGFVSDNPSSVEAIKASHENLRLAGRKAQRSLG
                     SGLLNVAYVATCLRDEFPYLRKQFNKTVVKWEPLFEADANMLTLIGDGVIKLNQAVPG
                     YMDAETIRDLTGIKGDMNATPKIEEVEQKSTNSEDKQKNRIISTYEITSLLSNYQKGV
                     LSKENGILLLTSTGMSKQEAEAMINKTELIVKEAADG"
     gene            complement(17146..17490)
                     /locus_tag="VVR18_001018"
     CDS             complement(17146..17490)
                     /locus_tag="VVR18_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HNH endonuclease"
                     /protein_id="HEU6032565.1"
                     /translation="MNTNPLRADRSGPHRVAFEKNKKIILKTRNTCGICGQPVDKDLR
                     YPHPLSPVIDHIVPVNKNGHPSDIANLQLAHWQCNRQKSDKLYADEKTNGTKVIGNRN
                     LPQSTDWFKYKG"
     gene            complement(17724..18290)
                     /locus_tag="VVR18_001019"
     CDS             complement(17724..18290)
                     /locus_tag="VVR18_001019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEU6032566.1"
                     /translation="MKKVEPIRDLDDIERIKDYLKNKSDRNYVLFMFGIYSGLRVSDI
                     VPLQVKQVIADRIELKEKKTGKIRYFPISPPLRKEINRYIKDNQLAEYDYLFPSKKKK
                     RTDGVRITHIGRVAVYQILQDAAKYVGLNHIGTHSMRKTFGYHHYKKNSNVAILQKIF
                     NHSTPDITLGYIGYSQDELDQSILSFDY"
     gene            complement(18579..19007)
                     /locus_tag="VVR18_001020"
     CDS             complement(18579..19007)
                     /locus_tag="VVR18_001020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001165370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEU6032567.1"
                     /translation="MQIELLDIIDEKKTRKEAIKVLKKYSRLRRIAGEEYAPKITISY
                     SLEPRSSSGQTSKQVESMVLRRVSAQQDLELIAKAINNLSDMEYTRILIERYCRKKRR
                     EDYSIYSELGYSSSEYYRILNKALLEFAESYQASNLLVYK"
     gene            complement(19079..19309)
                     /locus_tag="VVR18_001021"
     CDS             complement(19079..19309)
                     /locus_tag="VVR18_001021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000998323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032568.1"
                     /translation="MKDKLNPRQASRFAFLLKQKRKERKLSQEKLAAKLGYSRYLIAQ
                     WEKGESVPNIYNVEDICTYFAFPADIILGSRA"
     gene            complement(19299..19478)
                     /locus_tag="VVR18_001022"
     CDS             complement(19299..19478)
                     /locus_tag="VVR18_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032569.1"
                     /translation="MSEYALYEGDTFITMGTLAEISKETGIAERMLKYYTFASTQRRN
                     PNGRAVVKIEVDDEG"
     gene            complement(19471..19563)
                     /locus_tag="VVR18_001023"
     CDS             complement(19471..19563)
                     /locus_tag="VVR18_001023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032570.1"
                     /translation="MLRFQKKNGLEDLKKARKNLDWLIEEMEHE"
     gene            complement(19651..19839)
                     /locus_tag="VVR18_001024"
     CDS             complement(19651..19839)
                     /locus_tag="VVR18_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="topoisomerase"
                     /protein_id="HEU6032571.1"
                     /translation="MSCGENLKKEKELTAAISNFKIEVLQNDDKLSSLSLSNIKRQAR
                     DLYECLVWLQYNAEESGR"
     gene            complement(19839..20126)
                     /locus_tag="VVR18_001025"
     CDS             complement(19839..20126)
                     /locus_tag="VVR18_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000194862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032572.1"
                     /translation="MTQTLEEGMKNQSKCIKVPREIRPFDIGYRIVNKYGQALALRNG
                     ASIFDLPFLAEKAIEKEFGKNDPDFDIGKHSVEEVAIVNLSKFHSYFEGVE"
     gene            complement(20126..20725)
                     /locus_tag="VVR18_001026"
     CDS             complement(20126..20725)
                     /locus_tag="VVR18_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1642 domain-containing protein"
                     /protein_id="HEU6032573.1"
                     /translation="MNKDLIETPRFNFFIGDEVLLKGKIVGFDVDENKCVENVVRLEY
                     GQTLNVPNNNIYITDDIVDKSKIKVVVPQFVADWIEVCKEHLTTSLYTAMTPNFMKEN
                     NQSFDLILWIKKASNQDLFARAWLDGYEVEKEKRYLVKIKGNIKENMLVYGELLERYF
                     FTKSFSLDDAIYSHTRKELENAKIGWVFDCEGFEIEEVE"
     gene            complement(20718..21227)
                     /locus_tag="VVR18_001027"
     CDS             complement(20718..21227)
                     /locus_tag="VVR18_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1642 domain-containing protein"
                     /protein_id="HEU6032574.1"
                     /translation="MNKQELIEKYKKLEGVWNAEGAELARQIFLQDLEQLDKPKPVKV
                     PQCVAEYIEFKKKNNFHVYGAMRVIEDHYDKKVPEWFYENNIEKFCLAWLDGYEVEKE
                     KRYFVKIKGNIKENMLVYGELLKRYFFTKSFSLDDVIYSHTRKELEDANFGWVFDCEG
                     IDIEEVENE"
     gene            complement(21229..21546)
                     /locus_tag="VVR18_001028"
     CDS             complement(21229..21546)
                     /locus_tag="VVR18_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032575.1"
                     /translation="MMEELKKKVNAVYNWTVEDGKPQPPQQDLPQAVKDRADYFWEMA
                     EDGMTFMGAMECIFADEKPTDYDLGATKGWLPKSKEFDDWVGYSPGMSQVVIAVYLIY
                     GGN"
     gene            complement(21518..21727)
                     /locus_tag="VVR18_001029"
     CDS             complement(21518..21727)
                     /locus_tag="VVR18_001029"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032576.1"
                     /translation="MNYDKRTVIDGLKRTIEQNEEKIIEYSKPCDARKRRIRALERDL
                     LKKKNKELRRKAEELEDDGRVKEKS"
     gene            complement(21717..21881)
                     /locus_tag="VVR18_001030"
     CDS             complement(21717..21881)
                     /locus_tag="VVR18_001030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000233204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032577.1"
                     /translation="MVGVTYQEIHLFVEFLKEQYGQGRPDYIEALNDLDGLVEVSYRE
                     AIERFLEDEL"
     gene            complement(22008..22235)
                     /locus_tag="VVR18_001031"
     CDS             complement(22008..22235)
                     /locus_tag="VVR18_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032578.1"
                     /translation="MLELYFVYNGHCKFYLGTFDNVDDLIEQMEDHQWVFSAITHPRF
                     QKHIGQRTTRFDYGSKDCYYLATFSGGEKND"
     gene            complement(22235..22429)
                     /locus_tag="VVR18_001032"
     CDS             complement(22235..22429)
                     /locus_tag="VVR18_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032579.1"
                     /translation="MFILRHGTREDKPFLRSVVIGVTGLDISCSEEKKAMRFVSRGAA
                     VQVGKALRGSFGNFYPVEVE"
     gene            complement(22444..23214)
                     /locus_tag="VVR18_001033"
     CDS             complement(22444..23214)
                     /locus_tag="VVR18_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6032580.1"
                     /translation="MVDNVFDEIALSYHRNTEQQKELCDKHNIPLIKILRTESVVCRM
                     CESERIHEENQARVNELADAENERERKYYLEKFSLYDEVLKNATLDNFETPTEKEAEK
                     LVFAKRICREWSEGARNNIVLQGEAGTGKSHLAFAMVKALSEYTKEIAIFINVTDLLM
                     KIKADFSQEEFLVNKIASAKFLVLDDLGMEKDSEWSFTILYNILNKRSNTIITTNLTS
                     ADIQKRYGRPFMSRLMKGVDKDHLMVFNDLTNKRKQYF"
     gene            complement(23208..23366)
                     /locus_tag="VVR18_001034"
     CDS             complement(23208..23366)
                     /locus_tag="VVR18_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000511765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032581.1"
                     /translation="MGILELIEQFEIDYYPLSYEKKTLLANQPIHQVVACLSEMASWH
                     ECGGRLSW"
     gene            complement(23354..24142)
                     /locus_tag="VVR18_001035"
     CDS             complement(23354..24142)
                     /locus_tag="VVR18_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
                     /protein_id="HEU6032582.1"
                     /translation="MALKNKRYFWIQLAQDFFKSKEMKLLRKIAGGDTHTIIYLKMML
                     ISLEDGGHIYYDGLADNLAEEIALVIDENVEDIKITLIFLESKGLLTRNSNRDYFLEQ
                     VPEMVGSETASTRRSRKHRELQKLHCNTIATTCNGDIDIDKEIEKDKNNKVMISSSLS
                     ENLKHSGIRINDKQHQQLLEYVGIDGMNFDMLNRAIEITSEIHQPSFKYLRGILENWK
                     KKGFTSIEQVDENDQKYKEGKNYSRPGQQNDKTSEQEVRDEWGF"
     gene            complement(24133..24432)
                     /locus_tag="VVR18_001036"
     CDS             complement(24133..24432)
                     /locus_tag="VVR18_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032583.1"
                     /translation="MEELIESLDNLIMIVKGLEGRESTSRHFITIWENDYKNLLLVKE
                     YLTDYEKLAKDYRDVELKNKLLKIEKMELEGRYIYEDMRMKYRANRRKWGGRLWR"
     gene            complement(24448..24768)
                     /locus_tag="VVR18_001037"
     CDS             complement(24448..24768)
                     /locus_tag="VVR18_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032584.1"
                     /translation="MFEPPILDQLMGVGALLLGFAGACRHIKLQEQRKEEERREEQEF
                     ASMIIQVRNHAYERGREDKWQEIRKNIRREFKGFTYDNEPPVGLRPELLALPEPKQSA
                     IRFL"
     gene            complement(24854..25111)
                     /locus_tag="VVR18_001038"
     CDS             complement(24854..25111)
                     /locus_tag="VVR18_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU6032585.1"
                     /translation="MDNVLLSLSEWIKSIIKDTITRLVEIEKDSDHYPELMDVNTTCE
                     FLGIKYATFSDNYRYLKGFPKELPGKKWSKRAIKEWLSNQI"
     gene            complement(25123..25836)
                     /locus_tag="VVR18_001039"
     CDS             complement(25123..25836)
                     /locus_tag="VVR18_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HEU6032586.1"
                     /translation="MNEIFNFHGQEVRTLTIDDEPWFVGKDVADILGYAKPLDAISRH
                     VDEDDSVKYGLTDNLGRTQNTIIINESGLYSLILSSKLPQAKEFKRWVTSEVLPAIRK
                     QGGFIREDLDEDAFIALFTGQKKLREQQATMLEDIDYLKSEQPIHPSYAQSLLKKRKA
                     RVVACLGGIDSPAYADKTFAQSVFRQAEIDFKDHFNISRYDLLPKKHADAALAYWMTW
                     EPSTNTKMKIMKLNSFDEV"
     gene            complement(25979..26182)
                     /locus_tag="VVR18_001040"
     CDS             complement(25979..26182)
                     /locus_tag="VVR18_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032587.1"
                     /translation="MSKELKIIKAKIKTRLIELDMTQAELAKQVPVTSSVISELLKYG
                     KGSESVKEKVADVLGIENPWRNH"
     gene            complement(26175..26321)
                     /locus_tag="VVR18_001041"
     CDS             complement(26175..26321)
                     /locus_tag="VVR18_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001001334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032588.1"
                     /translation="MNEEDLKELLELLATDYGRGYLDGVVGGLSMLLKISKEAEKYRK
                     EKYE"
     gene            26607..26972
                     /locus_tag="VVR18_001042"
     CDS             26607..26972
                     /locus_tag="VVR18_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000484469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032589.1"
                     /translation="MFPTYEKIKELAKKQGLSINALEEKLGYSRNTLYSLKKQKASTE
                     RMQEIADYFNVSLDYLLGRTDNPAIAGNSKEYTWQGKTLNVEEMASNVMMFGGRELTD
                     EKKKIIQSIIEGYLKEAGD"
     gene            26985..27368
                     /locus_tag="VVR18_001043"
     CDS             26985..27368
                     /locus_tag="VVR18_001043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="HEU6032590.1"
                     /translation="MTEKEIISHFQVRIVDFDGELIPDELGFYEKETNTAFLSNKLSK
                     KERVKVLLHELGHKDHTRSEYQNARLRCENEADRNMIHHLVKDALESLDDPTEFDYLK
                     FMSYYNLKTVTNEIMVKEEYKSLVG"
     gene            27380..28294
                     /locus_tag="VVR18_001044"
     CDS             27380..28294
                     /locus_tag="VVR18_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIRAN domain-containing protein"
                     /protein_id="HEU6032591.1"
                     /translation="MKIGMRKPSLTRSLKARTTSKWKRQAKKAIIPGYGKKGMGWVKN
                     PKKAMYNKVYHKTTFGLSDLFKSSKKRKKKVVNNKQQSILASNGKKQHTPKEYKEAGL
                     VFMFLGAIFLFLFPPLGFFLFITGFITYIIGRLTAKREKKKKVENYSPQIDTIVFRDD
                     FLLMGTNYHQEEAEIAADFLSKGVHYFGKDNKSLKSYMLETYKPVYKYNKLKTVDVQL
                     LPEPSNPHDKNAVKVLVNNIFVGYLPAMIATQVSSYISNPNYRYDAILTGRGGPYKTL
                     NIETERVVSRKSDLTYYLDLTVWRLAKK"
     gene            28466..29614
                     /locus_tag="VVR18_001045"
     CDS             28466..29614
                     /locus_tag="VVR18_001045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000876726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEU6032592.1"
                     /translation="MKYNKTKYPNIYYYETAKGKRYYVRRSFFFRGKKREKSKSGLTT
                     LPQARAALVELEQQIQEQELGINTNLTLDQYWDIYSEKRLSTGRWNDTSYYLNDNLYK
                     NHIKAKFGSTLLKNLDRNEYELFIAEKLQNHTRYTVQTLNSSFMALLNDAVKNGNLLS
                     NRLKGVFIGQSDIPAANKKVTLKEFKTWIAKAEEIMPKQFYALTYLTIFGLRRGEVFG
                     LRPMDITQNDSGRAILHLRDSRSNQTLKGKGGLKTKDSERYVCLDDIGTDLIYYLIAE
                     ASKIKRKLGIIKEQHKDYITINEKGGLINPNQLNRNFNLVNEATGLHVTPHMMRHFFT
                     TQSIIAGVPLEQLSQALGHTKVYMTDRYNQVEDELAEATTDLFLSHIR"
BASE COUNT         8326 a         7006 c         5087 g         9299 t
ORIGIN      
        1 ctgaataaga agtatctaca tcgcttattt caaacttcgg catccaaatc caaatggttc
       61 cttcttggtt gaaattgaac aaccattcat ttgtggtctg cttggattcg tttgtccaac
      121 cttttggaat atggacaaca tatcgtttaa tttctgtcga caatgtcaca tttccagttt
      181 tatatccgat attccctaat cgagatctta gcattattcc atttttattt gccttagcat
      241 aaaaactaat ggttacatct tgattagtcg tacttccggg aattactttc ccgaattgac
      301 ccagagctgg ataagtaacc ttgggattac ctccatcacg gccagatgga ttcagaccta
      361 taattttaag agccttgtgt ccaagatact tactttcgct atcgatagta gccgtatatg
      421 tactcgttgt ccaaattcct gtttttggaa tatcctgctt gaatagtgag ttcaagaata
      481 gatttcgacc ggatgcctgc acactcgcta tcttactagc cagctcctca gctgtctgcg
      541 tgagttctga cttgttggct ttatccttgg ttgcgttcag gatttcctga cggatagagc
      601 cggctcgcac ctcaaattca gcctgactca acttctgatt tagtttgttc tgcgtgtctg
      661 tctcaagact cttcacagat tgccggatat tctcagcagt cacattgagt gagctgatat
      721 ccgctttggt tctaaggcct tcagtcaagc ttctcacacc agcgtcgagc gagttggctc
      781 gttgtttaaa ggtcgattca actgttgaaa tctgaccttc tatatcttca ggagcttctt
      841 ttgagcttgt tgccaaactt ccgtcttcca gctggggcgc aagaacatct aaatattctc
      901 cgacctcagc atttacgaga tacacatagc caattgatgc gactccagcc ctatttctag
      961 cgctagtaaa cgatagcttt gtccaatttt catcctttaa tgtaaagatg ggcgaaatac
     1021 ccgaattatc attggcttgc caataagttt gtagcttgac cttttgacct cttctgcctt
     1081 tgacccaaca agacatcgtg tatgtgcctt gcgagatata aaatccatct tgagcaatac
     1141 ctatttggtc tctagcattg cttgaggtca atcgtatcgc tttatcaaag ccagttactg
     1201 gactgtctga tacatcaatc gtctttgccg tcccagcgcc tgacggtcta aaagtacctg
     1261 atgcccacaa tcctctggct agcatcatgc gctttgtacc ccggatataa ttcctacccc
     1321 cgacctgcac actcgctatc ttactagaga gctcctcagc tgtctgcgtg agttctgact
     1381 tgctggcttt atccttggtt gcattcagga tttcctgacg gatagagccg gctcgcacct
     1441 caaattcagc ctgactcaac ttctgattta gcttgttctg cgtgtctgtc tcaaggctct
     1501 tcacagattg ccggatattt tcagcagtca cattgagtga gctgatatcg gctttggttc
     1561 taaggccttc agtcagacgg cttacaccag cttcgagtga atcagcacgc tgtttaaagt
     1621 tggattcgac cgctgagaca cggtcttctt ggtcttcgta tgctggtgac cagtcacctg
     1681 caagatttcc ctcaaaaatg gcaggggcgc agatttcaac ccataccccc tctttaccgc
     1741 ctacttgagg gccatggcgg ccaatgatga ccgtcttggc ttgatctgtt gcggtttggg
     1801 tccatttaac ccagcacaac tgccagtctg tcgagagacg gataatagac aagccatctg
     1861 acgaccttga cttatatccg ctgctgtttt ctgatgatac aaccgtgtta ggattgtaaa
     1921 aatgacagcg cacaggatag tcattttcac tggctcgtgc ataaaagata gctatatact
     1981 ctgtcccagc cgttggtata acggttcttt ccacatagct atcctgatat ctagttgctc
     2041 ctgcgactgt tctgataact ttaaaaccat tatattcact aaccggcttg tatctcgcaa
     2101 gctcttttgt gcctttcagc aaatttctgc gccctaagtg cacactcgct atcttactag
     2161 ctagctcctc agctgtctgc gtgagttctg acttgctggc tttatccttg gttgcgttca
     2221 ggatttcctg acggatagag ccagctcgca cctcaaattc agcctgactc aacttctgat
     2281 ttagcttgtt ctgcgtgtct gtctcaaggc tcttcacaga ttgccggata ttttcagcag
     2341 tcacattgag tgcgctgata tcggctttag ttctaaggcc ttcagtcaga cgattcacac
     2401 cagcggcgag tgaatcagca cgctgtttga aggtcgattc gactactgag acacggtctt
     2461 cttggtcttc atacgctggt tgataggctg gaaaataatt accaaccgat aacatagcgt
     2521 tctcaatgac gacctgcaga ccagcaggaa atccataatt agtaccaaaa cgaatgaaca
     2581 cattattagt ctgatagtcc tcagaagaac tagacaagtc aatcgtaaac tcaaaatgtt
     2641 ggcgttcgac agtgccacct ttaaaaatta agtttctgta ggcataccat ggatgagcac
     2701 taaaatgcac catagcaggc atgtcattta ctagggcgac agggaaagtc acatcaaaag
     2761 atatgcgaac ataatcacgc ttgaacctgt cactgttctt ccagaaatca ggaactatga
     2821 atgttcgata gtcgtatacc gcttgacctc ctgttgtgaa cgttcttgaa cgtgaattcc
     2881 tgaagtaatt ccgtgaacta cctgcctgca cactcgctat ccgactagcc agctcctcag
     2941 ctgtctgcgt gagttctgac ttgctggctt taccattggc caagttggtc agttctgaca
     3001 gtctacgagt cgtcgtctcc tcatacgtcg cttgcgctga cttcacgcca gccagttcat
     3061 ttttagtccg gctaagtgct tcaacttgct tggcaatctc agtttcagcc tgtgcttgct
     3121 tcggtcgaat atcattcgcg atagttcgtt ttagaacatc caagtcaccc gacagagccg
     3181 tttgtgcgct cgtagtctgc gacttaaacg cttcaagtct agcaacagaa tccagctcaa
     3241 tccgcttagc ttcctgtgca agcagggtac ttgcgccatc cagttcattt ttagtccggc
     3301 taagtgcttc aacttgcttg gcaatctcag cttcagcctg tgcttgcttc ggtcgaatat
     3361 cattcgcgat agtccgtttc agagcgtcca agtcacccga cagagccgtt tgtgcgctcg
     3421 tagtctgcga cttaaacgct tcaagtctag caacagaatc cagcccaatc cgcttggatt
     3481 cctgagcaag agaactactt gcgccagcat ttcgcaaagc ttcctcagcc ttgcgcttag
     3541 cttctttcaa tggcccgttg tcaaagctat taaagcgctg attgatagtg tcagacagtt
     3601 cttgcttgac ttcttccgct ttggccttgg caagttcgat ggcatccgtg atggttttct
     3661 cacgcttgga aaattcagcg tcaaaggcac ggtcagcgtt ggcgatttcc tttttcaaac
     3721 gttcttcaaa aatctgatgc agatttcggc tttcattcaa aacggcatca tttacaatcc
     3781 caccgatcgc atttgcaaga ctggactgga aggttccaaa acctattgat tttaggagtt
     3841 ttgccattgg cgaataggta tatttggtga ttttcttacg aacatcaaga ccgtaccact
     3901 catggtagaa actgaccaca tcaaacatct gcaccgcaac atcactctga ccgacaaccg
     3961 agatttcaag gttatcttct agcatgtcgc acatacttgt ccgaaaatac tgcttaccgt
     4021 attcaatcaa gctagcctca tctgtcacgt cttggtcatt gacttccacc acatcttcgt
     4081 agatttggct gtagttccca agtaaggggc tgtcaatcac caccatataa tcatggtcaa
     4141 ccgcattttc tccctcgccc ttaacagtcg ttttaaaggt tatccgagtt tttaaagact
     4201 tcgttgaggt cttatgctgg tagctggaca agtttttctt gtacataaaa agcgattcat
     4261 tttcagaacc gccattcttc aacaagcgta aattgtagcc gtttcgcacc atatctccgc
     4321 cccactgacc aaggatagaa tgcttgcctt tggccaagac ctccatggca ttcttatcct
     4381 tgatattgag cgtatgccta tcatcaatat cagagaagaa agaaaaagga ttggctctgg
     4441 taatactacc agcaaaagca ctcaacaccc ttgtcccact gacacggtca acctcgatag
     4501 agctgacgat gtagttattt aacaggctga taacctgatt ggcatagact tgaatatatc
     4561 cttgttgctt ttcaacctca aaaatataaa aatcctgctc accatgcagg tcatctgcag
     4621 tcagaaaagt ttcctctttc agtaattccc acttgggatc cgatgtagga aaacgaaagg
     4681 tcagttgata ggtattgttc cccaaatgga caatttcatc attgtaggcc tcatttaaag
     4741 gtgtattgcc ttcagtaaga taaatcataa gatatacctc caattcggcc gaaccgtgac
     4801 cttgcgaacc gaaccagtaa agaccagact gttattacca actgccaact caaagaagcc
     4861 tccacgttta cgtaaagtat tttgaaccgc gccatctgca ttatagatat tctgtttctt
     4921 atgcctacaa tcaatggtca cttttcgtct aacggtcaag tgcatagttg tccttccgat
     4981 agtcaaagaa atatcaccgt ctccctcaat ctcaatcaca ggctcgctat agacagagcc
     5041 tggattgttg atatttccac ttgcggtaaa gataagagga gcaacatttt tctgataacg
     5101 gaacggttgc atgttcaact tgatttctag tttccaggca tgcatcccat gagggctata
     5161 ggttgcacca ataaaatccg cataaaatac agaccccaac tggtagctaa actctagcac
     5221 attgtcctta ggctgaaatt tctccacgat agtagaaaca tccagtaact taggaatata
     5281 gaacgaaaaa gtccgttcat aactctcata gccaccatcc agcactcgat aacttccgtt
     5341 ggctccgtag aggttagcat cttcaaccac cctaggttta gctgcctcca cctgaccaaa
     5401 atccgtcacc acgcagtgag ggatagttga tgtattaaac ccattgataa tcatataaaa
     5461 cattacattc cctccctagc ataaatcgca ccttgacgtt ggtagacgct cattgaaatt
     5521 ttatcagcgt ctaggtaagt atctgacggc ttttcaagga tagcagtaag gattttctcc
     5581 atacttgctc tcagaatcgc tatctcagac acggtttgac tgtctttcgc ctcgatttga
     5641 gcgcttggca tggccaaact tgcttcaata tttttggcaa tagtcggtgt tccactcaag
     5701 ccaaaatcat cgtttgaaaa tgcgtttgaa atttcgccag ccattccact gacagatttc
     5761 ttaacatctt tgaaacggtc ctgcaaccct ctatccaaac cttgcataat cgcattacca
     5821 gcaggaatca agagcttgcg gtcatactca atcggacctt tgtggtcacg aatccagcta
     5881 gcaataccac caacgaagtc agttactgct ccccaagcag acttcaaacc gcctaggaat
     5941 ccatcaagga tagccttacc tgctgaccat aggtcaatgt ttcgaatgcc atcaaagata
     6001 ctcgtaacat tacttacaag gtcacgaaca ccttgtttca tgctttccca tgcattttta
     6061 gctccttgga caagtccgtc aatcagacct aagacggttg atttcaaccc ttcccaagca
     6121 ctgcttgcta cagatttgat tgtattccag atgttagata atatctgagc aaaactatca
     6181 aagatagctt tacctgcagc agacaaccct ttccaaattg tactaagagt ggtagaaaag
     6241 ttttcaaaaa tagcaatacc ataacctacg ataacatcca cgactccaga gaagtatgtt
     6301 ttaatccctt cccaaatcat agagatacta tttttaatcc ctttccagat tagagaaaga
     6361 tcagccccca gctggttaaa gttccctatc acaaggttga tgatgatgag aatagcaccc
     6421 aagaaaatag acttgatgaa ttcccaaacg ccttggaaaa tcatcttaat cccttcccaa
     6481 atttgggtaa gaccatctga aatattgttc caaatattca tgaatccatc aatgaacggt
     6541 tgaacaatag ccatcactgc tgttgtgata gctgtccatg ccacagatgc agcttcttga
     6601 atccttaccc acaagtcaga aaagaatgtt acaacagcat tccaggctgt aacaactcca
     6661 tcccacaatg tgctagcacc ttcagagatg ccagaccaaa ggtttacaaa gaaatcagca
     6721 atcccctgcc aagcctgttt gatccaagct acaaaagatg accagatttg tctacctgtt
     6781 tcagtttgag tgaagaaata aaccaaacct gcagttagtc ctgcaatcgc tgcgatggca
     6841 attccaatag gattggcact cattacagta aatagacccg tgactgctgt tttaattgtc
     6901 gttaagacag caggtattcc agatagcaat cccgagactg tcgaaaatgc tttaaacgct
     6961 aaaaatgcag aaccaagagc ggtaacgata ctacccatga tacttcctag accttcacca
     7021 aagattccac tgaaaacacc ctttatccct cccaaaataa ggataggaat ttgtttcaga
     7081 atatttccaa tcattggaat taggtttccg aaaagaaatg ttgatgtcgt ttccatcaaa
     7141 gcttgtagtg caggttgaat atcttcacct aaagacaact ttccaagcac attctgagca
     7201 gctgatttca tcgattcaaa tgaacctgta aatgtagttg ctgcctctct agctgtcgta
     7261 ccagtgatgt ccaaattctc ttgtatagtg tgaatggcgc tataaacgtc tgatagatta
     7321 ttgatgtcat atttaacacc tgtcaatttt tcagcatccg ccaaaagtcg ttgcatttct
     7381 tgcttcgtac caccataacc caatttaagg ttgtctagca tcgtataatt ttgcttggca
     7441 aaaccttgat aagccagttg aatactttcc atagatgtcc ccatcttatt ggcattatcc
     7501 gacatatcaa tcatggccat gttagctgtt tctgctgctt tatctgtatc tccaccaaga
     7561 gattgtagca agcttgctga gaaacctgta acattttcca tataggcatt ggctgagaga
     7621 cctgttgtct tgtaagcctc gttcgcaaat cctttgacct tatcagctga gtctttaaat
     7681 aaggtttcaa cccctccaag agattgttga agtgctgccc cttcgtttat cgatgctccg
     7741 attgctttac caattccagc tgcagcaata actcctgaaa cagcccccat cattttagat
     7801 ccgagggatt cgcctgcgct aacgccagct gaggcaactt caccacccat ttccttttga
     7861 atcatgccac taatgccttt agcagatgga atgatttgta cataggcttt tcctaattcg
     7921 gtcgccacta atcctcacct cctgtttttg caagcaaagc cttgcgatag ttttcaaagt
     7981 cctcaccaga ttcaaagacg agataatccc ttttatctcc ctcttctttg ttattctttg
     8041 taagtaattc agcaattgat gcaggacgat taacaccctt ttgcccatct tttgttttca
     8101 accacaaaga aagagacagt ctgtctacga tacttgcaag taacgtcgtt tcaagaggga
     8161 cgatttggtc agacatcatc tgctttatcc gcgaatcatc acgcaaccca tacgcaaaaa
     8221 cagccacctg atttaaaggt agctgtttat agtcgtatat ttggtaggtt tccgctaaat
     8281 cacagataag agcatcctcg tctaaggcaa tcatctgagc aaggactaag atttttttag
     8341 gtctttgttg gactcaaaga tactcttgat atctgcgaac agtacctcag tatcgatgaa
     8401 gtcgtctcca tcatctaaat gagataaaaa ctcttccgct tgttttttac caaagagaag
     8461 attcagcaat ttttcagcag cttcaaaatc ccccttctcc attttggacg cttcgcgcat
     8521 gagataaaag tttctcaatc gttttttagg gattttgtac tcaaaccctg actctgtttt
     8581 tccttttaag attgcttcca tttattttac gctccttgaa tgtattcgta gtgagtgttt
     8641 tcactgttgt ctggtaatgc agtgatcgtc aattcatagc cgataggttc gccgtcttta
     8701 tagctgattt cgccaatttc gctaacctta ccacgaggaa tgacaacgcg tttcacatag
     8761 ccatttttca gcaaagtatc aataaccaag caatgttctg gcaactcttt accgttggct
     8821 tttacagtga tacctgtttc aagcgttcct gagacgttat ctggtccata gacttctttc
     8881 aagacttcaa tgttcagacc ttcaattaat ttgtatttga aggtatcttt cttttcagtt
     8941 tgagaagaca agactgtttg tccaccccac gctttgattg ctttgctttc tggcgagttc
     9001 gcattggtca atccatcatc tgaaatgtac cctagcgttt taaatgctgc atccaaatct
     9061 gttttggcat tcgttggaag agttgttcca gctggagcag tagaaactgc ccctccaatt
     9121 ttcggcttag cagccgttac atttgatgct gatgcagtcg tcatattctt tcctcctgtt
     9181 gattctgtat tttgtcttct tgcttctgtc gtcaaaacta cacctccttt ttaaaaataa
     9241 ttaatgtcat ataccgcttg atagcgatat tgcttcgttt ccgtgtctgt aaagttgtag
     9301 tcactattgt gatgcacacc gctgacttcg ttgaccgtga tgagatcctc aactactttc
     9361 ttgactttct cattcagctc agcagccttt tgaagtgatg gtgcataact ttgaaaagcg
     9421 aatgtagcgg aatgaacgta gtcgcttcca ccacttccag tcttttctaa aatgacataa
     9481 ctctcaggca tattcggttt atgttcaaaa aaagacggta catctaactg tccgtccaaa
     9541 aatttcttta taactaattc gatcatctca tagccttcag taaaatatta tgttttttat
     9601 ttctagccat gctcttgata tcagtcgtac taatctttgc attggcacgc ttttgccctg
     9661 gcgatacagt caattcaaac ccctcaccag ctctttcagc aatcccttgc cctttctccc
     9721 tcaaaatacc ctgcatttcg gaagaacgta gcaaggcaga caccccagcc gagttcaatt
     9781 gaaatttcat attactcata aacttcaacc atgacctttc tattccaaga taatggaatc
     9841 attgactcaa tcccctcttg agggatgcca atcgtccgcc atttacgacc aaaaaacttg
     9901 acctcacggt tctcccactt attagtgtct cctttaggaa taccaagtgt atattccgcc
     9961 tttttcccag tcaaattcat ttgattgatg acgtcctctg atgaagttgg ggcaaccaat
    10021 acattttgaa cctcaatctc aacatcacga tgaattggat gaccgaaatc gtcattacca
    10081 atttccacct tgtccactaa aatgacaggg attcctttta ggtaggtcat aaatctcaat
    10141 cgctccatat cgttgttttt tcttcaaacc aagcctttta agttcggtat ctttgataaa
    10201 gagaccccct ccaggcacaa ggtaagaacc actaaacgaa taacccaagg cactttcaga
    10261 aacctgagtc atcggttcat ggtctgttga ggtcatgagg gttcgtgcta cgatatcaac
    10321 cgtgacagac ttagcaacac tagcgaatga cacgctctca gctaccatat catcaaggtc
    10381 tttaccgact ttttcagcct ccactcgcaa agaattagat acaacttcca acagagcctc
    10441 agcccttgca cgctcatcaa atttcaacga gcgccacaac aattccaagt cttcaatctt
    10501 tgcaaaattt cccatagctt aacccttgtt ttcctcgtac aaggctacca aatcggattt
    10561 ttttgaactc ttatcgtaat caatgcctaa ttcatccaaa ctagacttca attccgctac
    10621 ggtcaaatcc gctccgcttg gtgccgtatc ttccacaggc acccaatctc cgccaagaat
    10681 gctctcagca gagataatca cgcccgtttt tgtatcacgg tataaagcca taaaacttac
    10741 gctttcacac gcgcaaaggc atcttcatca aggatacccc aaccaataaa ggcttccgca
    10801 cgcaaacaga tttcattgta ggctttaagg tcacgaccag caccgtctgg atcaccgtat
    10861 tcaatgattt ccattggaat attttcagca taaccccact tgaagcggtt ttggaaatcc
    10921 ccgacaatag catggtctgt ctcggcacta ccaccagtta cagtaaggtt cttgttgata
    10981 tctgatttca ttccgtagaa cgaatctgga ttttgaccaa aacggaactc aggatattga
    11041 acgacatcct ttactttaac tttcgccaat gcttgacctg cagttggtga caaggcaata
    11101 cctgttacct cgcaaccacg ggcaataacc tgttgtactg catcttcaat attttcatca
    11161 atttttgctt catcatacgt cacggtactt ccgctaatca caccatcaaa tgagtttgtt
    11221 gcacggaaag aggcatccgt cattgttttt ggttccaaac catgaagagc agcaaggtca
    11281 aaggcttctg caatcttctt agcaaaaccg tccatataag ctgacaagaa gttcattcgt
    11341 ttttcttctg aagcgtattg aaactcatct gtaatacggg cttgataaac aaatttaagc
    11401 ggtttgataa ttttcgaagt caacttcgct ttatttccaa gtttttgctc accctcacca
    11461 acgatttgcg cattaccttc aaggttgaag atgaattgct ccaccccatt aaatggaatt
    11521 ggggtttgtg ccgacaattt agccagtaca gatttcccct gtaccttgct aatcaattct
    11581 gttactagtt ctggtttaaa aagtgttcca gctttcattg cattatctgc cataaattct
    11641 attctccttt tggttgtaat tcacgaagca tctgcttcat ttgcgtagtt ttgtcatcac
    11701 cgatagcagg ctccgtatct cttagtggcg ctggaggtgt tgctggacgc ataaagccag
    11761 ctagacgctc agcgtcagcc tttaatgcct cttcgtcagc gccttgaaga cggtcagcca
    11821 agtcataagg caagccattt tgtaaagcga tacgagttcg caagctagca gtttcataat
    11881 tgctcacttg cccctgcaat tcagtgattt gagcatctaa tcctgctctg gtttgcttgt
    11941 catcttcaac agtagacttc aaagcactgt tttcagattc cagttctgaa acacgtttct
    12001 tgagttcatc ataatcaccg aatttttcac gctcacgtct gatacgttcc ttcacgatgt
    12061 tatctagctc ttcctgtgtt tcaatcgttt taaattcaga catcttcatg tctcctttct
    12121 cctgctttcc cggcagttcg gtaatttttt aggcatcaaa aaaagcagtc tctcaaccgc
    12181 tcctcttaat aactgatttt ttgctttttc ttaggcttag ttgtcacaca agcccaatgc
    12241 gcaagcaagg cgctatccat caaagaaata tccatatccg caaaatgcga gcgatagcca
    12301 aacccaccat ttgaaccgat gttccgcttc tcgcagttgg ttgtgatttt cttcaaagac
    12361 ggttgaccag catggcacaa ggtcttttga taaatccctt gttcccacat cgagttagcc
    12421 acgatgattt ccttaaccgt aggcaatatc acgctcttca tgcgttcctt tttcaactct
    12481 tcatcaagga ttttctgacc gcttgctcca tcgactacga tagtagccac atcggcacgc
    12541 ttgacaaaat ccaagatcca gtcattcccg ttacggactg actgacagtc aattgtctca
    12601 acgaaaatcc gttcatctac agtacgaaca gcaatactta atgccacgtt tgcgccatct
    12661 tgaccatatt tgactccgac aaacaactta cctgataaat caggcataga gtcaacacac
    12721 aactcattcc attccgtttc cgaaatagca gatttctggt tgtattcagg ccaataaccc
    12781 aaacgctgaa cattatggtc tagcttatca tcaccaagct cagcttctat cttccgctca
    12841 ttcaaatggt aacccataga gggattggaa ttataccagg catcgacatc atcgatttct
    12901 ttttcctcag aaaccgacca ttctgcccaa ccagagtatt ttcctttccc aaaaaggcaa
    12961 ttcttacggt aatttgtgaa taccgtccca tttgaaacag gtgtaggagg tgtcccacac
    13021 atgattgtaa ttggattgct actatccgtt accgtatatt tcaaagccga ttcctgctca
    13081 gtcgtatatt cctgagcctc atcgataacg agaaggtcaa aaccttcccc caaaccacca
    13141 ttggatgttc tggtacgaaa ttgtacaatc ccaccgccgt caaacagttc aatccgctct
    13201 tgtcccttgg ctcgtataga gctaaagtcc tcaccgtcca catatcccat tttttcaagg
    13261 taacatttca ccttttcaaa agaggaatga gaggtggata ttctatgagc cgtgtgtagg
    13321 atgtttagtc cattatgcag gccccaaagt tcaaaaagat acaagagttc ggacttccca
    13381 ttacgacgag gaatagagta gccaaatttt tgatgcaccc acaaaccatt cttgtcaacc
    13441 gccatgatag aggtcaacaa gttgacttgc caagcgtagc aagaaagacc cgtccgctcg
    13501 tagatttcta ccgcttcttt cgccttagaa tttttcttga cgtactttaa aattaccgat
    13561 tgagtaggat tctgattgcc aagtttcttt ctagccatcc actgctcctt tcaatcgtac
    13621 cgcatgataa ccctatcgct gggatgattt aattgattac gtttaaaata tagtttttag
    13681 caacatctag cattcccaat gcctgcaaac tactatccca gctatagcca agatttatct
    13741 caccatcttt atccaaagaa actaccaaca ccgaagtgta gtcatgacta gcctcaagat
    13801 tttcctccaa aatttctttc acggaagcac cgcgctccag actagacttt ttctctaaaa
    13861 aataaatcgt gtttcccatt gttactcctt tctaagcata agaaaagcac ccttgcgagt
    13921 gctctaacat attattttct atctgaaaag aaatcttccc aaaatggatt ttctttatca
    13981 aagatttcaa tctcctcaga agtcatgttt tgaggataat cttcaaaaag gttatagaac
    14041 ttctttttat caaatgtgat aagcatcaat cctttggcat accatgaagt atcaacccac
    14101 caagttttat catcatcgtt ttccttgtaa caatactctg accaattcac ttcttcgtaa
    14161 tcacttttca tatcctgtaa tacctttcat ttgtttagat tcagctgtgt taaggaaact
    14221 caatatgtta tgaaattcag ggttgtcttt taatgaattt gcatcaataa gatagctatc
    14281 tacatcatat ttatgtcccc ttacagcatg agatttctta gccttaaatc tttttttcaa
    14341 aacagtgtca tcaaatggct taaacccatt tacaaatttt gattgaagct ccaaatattc
    14401 aactagatta tcatttttcc taatgattgc agcatgtcta cctgttgcca aatagtattc
    14461 tttgccattt tctgcctttt ccaacaattc tttgaccgct ttgaagtcat ttgtgttttt
    14521 ggctacatgc atcttaacac ctggaaggct tccaatcata ttgattttat caatactacc
    14581 aaaaaaaacg caactctttc cacctctaaa atctagaact gtatatcccg ctttatttcc
    14641 tatgtaagca aatgctaagg atgaacaaga ccctttcgtc ttatctccac cactaatcgc
    14701 ttgaataatt tcttcttcgg ttaatttttt aaggcttttc gttatagggt ttgaagttat
    14761 acctatttga agagcaagct ttctaacctg actgacttca gattgtattc cgatgttctt
    14821 tcttgcttct attttatcac ttttatcact tttactccac gccttactcc aaacattttg
    14881 gacctttcca cttttaggat cataatcaac agtgcatcta caacgttgat gtcttcgata
    14941 aatatccttt ggaactcttg ggtatttgta agtaccttga acctcctgac accattcaca
    15001 acagtgataa gctgattttc ttacaatctc aggttgcaat ccagatttat gttgaaactc
    15061 cgcatttttc tggatgctat catcaattat tgattgagta aaattcacaa caggttcttc
    15121 taatagccaa cgaacatcat caaaactttc ctcactggct aaacgattaa ccagaccatc
    15181 aattcggtct tgattcaatt caggaacctg agcagttaac ccaattttag cctcagagtt
    15241 caaattcttc tgaacttgct cagtataatc actcacaagc tcgtaatttc gccccagaac
    15301 gtccgtcagc acacgttgag cgatattgta atacatttta ccgtctggta gcgtttcgtt
    15361 cgttagagag gctcccagag ccttagaaag tatctcccca atttcaatag catattgatt
    15421 agcgtccaaa taacttgcct tgctgtgttg tagtttagac agcaagtctt tcaagacctc
    15481 gctgtctagc ctagcacctt caaactcaga cttgattttc ttgagcaggc tcggaacgat
    15541 atcctcaacc atctgcagcc tccttcacaa ttaattcagt cttattaatc atagcttccg
    15601 cttcttgctt actcattcca gttgaggtta gtaagagtat tccgttttct tttgaaagta
    15661 cccctttttg atagttactc agtagagagg taatctcata tgtagaaatg attctatttt
    15721 tttgcttatc ctctgagtta gtactttttt gttctacttc ctcaattttc ggagtagcgt
    15781 tcatatcgcc tttgattcca gtcaagtcac ggatggtctc agcatccata tatccaggca
    15841 ccgcttgatt cagtttgata acaccatcac caatcaaggt caacatgtta gcgtccgcct
    15901 caaacaaagg ctcccacttc acgaccgttt tattgaactg tttcctcaaa tacggaaact
    15961 catcacgtaa acaagtagcc acataagcca cattcagcaa accagagccc aaagagcgct
    16021 gagccttccg accagctaac cgcaagttct catgactagc cttgatagct tcaacagatg
    16081 acggattgtc agaaacaaaa ccaagatcat ccaaggtcaa acccatctcc ccagcaaaac
    16141 cagcggctgc agtccgtaac tgctcagtaa aaggagacat gctggatgtg gtgaattgcc
    16201 ccacattcgg cttgtcccct tcatcatctt tggtaaaagt cagcaagcta gatacagtcg
    16261 ctttccaagt atcaatcgcc tcagcatctt gactcaatcc caacacatac ttctgaggga
    16321 atgaatagaa ctcagcagtc acatctgagc gctcaagcgt tcgtttagca tatctctgat
    16381 agtacatccc agctctagta attcgtgacc gaccaaacgg acggacagca tcaggtctat
    16441 gaatgactgg caccagcaaa ggaacacccg ttggatttcc gattgcaaac ggctttccat
    16501 ctttaggata gaaccaagtc acatcactag taaaataagc ctcaagcacg gcataaccat
    16561 tgtcatccct tttcaaaacg gcatagccct ctgtcagcaa gccagtgata ggatccagaa
    16621 caccagttgc attgcttgcc tcaataacct gcaaccgagg agcgtcatca tcgtcccctt
    16681 gcgagatgta gacaaaacaa cacgacccaa tcaatgctga aaggatcgcg ctatcaaaga
    16741 atacatcagg attgttctga gcaaagattt cattcgctcc aaattcgtca ttggcaaact
    16801 cacgaaatac caaacgatct gctagactgt caacaccctt agcagcccaa cctaagaccg
    16861 cccgatattg ttgcctgatt tgaggtggta tcgtaatacc aacatctatg tcattgtatt
    16921 gcatagcata ctgtttgtat ctagtatcta cacccatttt gtaattggct agcttcttcc
    16981 tgagatagcc catacctttc aatgtcattt tatacaacta cctttcattt cccgcgagaa
    17041 aaaatgtaca gtgacggtgt gaagccctaa agcaccgagg gggagggggt catcccccca
    17101 ccttggcagg aacactcgtc ctttttttta atcacgttta tttttttaac ccttatactt
    17161 aaaccaatct gtactttgtg gtaagttcct attaccaatg acctttgttc cgtttgtctt
    17221 ctcatcagca tatagcttgt cagacttctg tctattgcat tgccaatgcg ccaactgcaa
    17281 gttagcaatg tcagatggat gtccgttctt atttactgga acgatgtggt caatgactgg
    17341 acttaatgga tgaggatatc tcaggtcttt gtctacaggc tggccacata tcccacaagt
    17401 gtttcttgtc tttaagataa tcttcttatt cttctcaaag gctactctat ggggtccact
    17461 acggtccgct cggagggggt tggtattcat ctagggaggg agtcctttct ttttaatgga
    17521 gggggttggt attctcaaat gtacccctcg gtatctttca aagtaggggt gtttttagtg
    17581 cacccacccc ctcttgtatt taacatatct tatattctgt taaataaaat taaacaactt
    17641 caaagtcaag agtatcaagg cttctaccat atttttctaa aaactaattt acattttctc
    17701 attatgtaaa atagataggc tatttagtaa tcaaatgata gtatactctg gtcaagttcg
    17761 tcttgactat aaccgatata tcctagtgtg atgtctggtg tggaatgatt gaatatcttt
    17821 tgtaggatag ctacattact attctttttg taatgatgat atccaaatgt cttcctcatc
    17881 gaatgagttc ctatatgatt caaacctaca tatttagctg catcttgaag tatttgatag
    17941 actgctactc ttccaatgtg tgtgatacga acaccatctg ttctcttttt ctttttactt
    18001 ggaaagagat agtcgtactc tgctaactga ttatctttaa tgtatcgatt gatttctttt
    18061 ctgagagggg ggctgattgg aaaatacctt atcttaccag tcttcttctc ttttagttca
    18121 atcctatcag caatcacttg cttaacttga agaggtacta tgtcgctcac tcttaaacca
    18181 gagtaaattc caaacatgaa taaaacatag tttctatcac ttttgttttt caagtaatct
    18241 ttgattcgtt cgatatcgtc taaatcacga attggttcta ctttcttcat gtacctctcc
    18301 tttcctacat aaaaagccac tggtcgtggc attgaatatg acagtagctg gaattgaacc
    18361 agctggtcta gcagtaaaac gtacgcttgg taaaagtttc aaggagaccc aaacaacctg
    18421 ctaacctgtc cttactgtct aagaggccga agcctctata tttttaggag tcctcatgac
    18481 tgttcgctgc caatcattgg ataatactat tttagcacct ttttccgttc caattctccc
    18541 aagattttcc cagatttttc ccaagatttt cccagaaatc acttatagac taaaaggttg
    18601 cttgcttgat aggactctgc aaactctaat agagctttgt tcaatatccg ataatactca
    18661 ctagatgagt agcctagttc tgaataaata ctgtagtctt ccctcctctt tttcctgcaa
    18721 tatcgttcga ttaggatacg tgtgtattcc atatcggaaa gattgttgat tgctttagcg
    18781 attagttcta ggtcctgctg agctgatact ctacgcaaga ccatgctttc tacctgcttg
    18841 cttgtctgac cacttgatga ccttggctca agtgagtagg atattgttat tttgggggcg
    18901 tattcttctc cagctatccg tctcagacga ctgtattttt ttagtacttt gatagcttcc
    18961 tttctggttt tcttttcgtc gatgatatcc aataactcta tttgcacacg aactcctcct
    19021 catgatataa tagttatgcg aaactataac acgagaagtc agctgtgctg gctttttttc
    19081 atgccctact cccgagaata atatcagcag gaaaagcaaa gtaagtacag atatcttcta
    19141 cattatagat attcggtaca ctttccccct tctcccattg agcaatcaag tagcgactat
    19201 agcctagttt agctgctaac ttttcttgtg acaacttcct ttccttacgt ttttgcttta
    19261 gcaagaaagc aaacctactt gcttgtcttg gatttaattt atccttcatc atccacctca
    19321 atctttacga cagctctacc atttggattg cgtctttggg tggatgcaaa agtgtaatac
    19381 ttcaacatcc tttcagcaat tcctgtttct ttgctgattt ccgcaagcgt ccccatggta
    19441 ataaaggtgt cgccttcata caatgcgtat tcactcatgc tccatctcct caatcaacca
    19501 atcaaggttc ttgcgtgctt tcttcaggtc ttccagaccg tttttctttt gaaaccgtaa
    19561 catatacttg attcggagaa ctatatttag gttcagcaat acaaatataa tctccactct
    19621 ctattttcgc taagatttcc aaatcataac tcatctacct gattcctccg cattatactg
    19681 caaccatact aagcattcat atagatccct tgcttgcctt ttgatgttgc ttaatgatag
    19741 actgctcaat ttatcatcat tttgtaagac ttctatcttg aaatttgaaa tagcagcagt
    19801 caattctttt tcttttttta aattttcacc acatgacatc actccacccc ctcaaagtaa
    19861 ctatgaaatt tacttaaatt gacaatagcg acctcttcaa cagaatgctt tccgatgtca
    19921 aagtctggat cattcttccc aaattctttt tctatagctt tttcagccag aaaaggcaaa
    19981 tcgaatatac ttgccccatt tcttaaagcg agcgcttgac cgtatttgtt cactattcga
    20041 taccctatat caaacggtct gatttccctt gggactttta tgcatttact ttgattcttc
    20101 attccttctt caagtgtttg tgtcatcact ccacctcctc aatctcaaac ccttcacaat
    20161 caaacaccca gccgattttt gcattttcta gttctttacg ggtgtgggaa tatatagcat
    20221 cgtctaaact aaagcttttt gtaaagaagt acctttccaa aagttctcca taaaccaaca
    20281 tattttcttt aatattccct ttaatcttta ccagataccg cttctctttt tcgacctcat
    20341 agccgtcaag ccatgcgcga gcgaagaggt cttggttgct cgccttttta atccataata
    20401 taagatcgaa actttggttg ttttctttca taaagtttgg agtcatagca gtatatagac
    20461 tagttgttaa atgttcttta caaacctcaa tccaatccgc cacaaactgc ggtactacga
    20521 ctttaatttt ggatttatca acgatgtcgt ctgtaatata aatattattg ttgggtacat
    20581 tgagagtttg cccgtattcc aatctaacaa cattttcaac gcacttgttc tcatccacat
    20641 caaaaccgac tattttccct ttcaagagaa cttcatcccc tataaaaaag ttaaagcgtg
    20701 gtgtttcaat tagatcttta ttcattttcc acctcctcta tatcaattcc ttcacaatca
    20761 aacacccagc cgaagtttgc gtcttctagt tctttacggg tgtgggaata tataacatcg
    20821 tctaaactaa agctttttgt aaagaaatac cttttcaaaa gttctccata aaccaacata
    20881 ttttctttaa tattcccttt aatcttaaca aaataccgct tctctttttc aacctcgtag
    20941 ccgtcaagcc aagcaagaca gaatttttcg atgttatttt cgtaaaacca ctcaggaact
    21001 ttcttatcat aatgatcttc aattactctc attgcaccgt aaacatgaaa attgtttttc
    21061 tttttaaatt ctatatattc cgccacacac tgcggaactt tgactggttt tggtttatct
    21121 agttgttcca agtcttgcag aaaaatttga cgagctagtt ctgctccttc agcattccat
    21181 acaccctcaa gttttttata tttctcaatc aattcctgct tattcatctt agtttcctcc
    21241 ataaatcaaa taaactgcaa taactacctg agacattcct ggcgaatagc caacccaatc
    21301 atcaaactcc ttagattttg gcaaccaacc cttagtagct cccaaatcat agtctgtagg
    21361 cttttcatca gcgaagatgc attccatcgc tcccataaac gtcataccat cttctgccat
    21421 ttcccaaaaa tagtccgccc ggtctttcac tgcttgtggt aaatcttgct ggggaggttg
    21481 cggcttcccg tcttctaccg tccagttgta tactgcatta acttttttct ttaactcttc
    21541 catcatcttc caactcctcc gctttccgtc ttaattcttt attctttttc ttcaacaaat
    21601 cgcgctccag cgctctaatc cgtctcttgc gtgcatcaca cggcttcgaa tactcgatta
    21661 tcttctcttc gttttgctcg attgtgcgtt tcagtccatc aatgactgtt cgtttatcat
    21721 aattcatctt ctaaaaatct ttcaatagct tctctgtagg agacttccac cagaccgtct
    21781 aagtcgttca gggcttcaat atagtctgga cgcccttgtc catactgctc tttcaaaaat
    21841 tcaacaaaga gatgaatttc ctgataggtt actccaacca tatttcttac ctcccactaa
    21901 aaatgtaacg ttattgatca tctttctttt cctttcttgc tgcacgttcc ccgactaaat
    21961 agccgagaaa taaccacaga atagccattc caaattcttt aataagttca atcatttttt
    22021 tctcctcctg aaaaagtcgc taaatagtaa caatccttcg aaccgtagtc aaaccgtgtc
    22081 gtccgctgac caatgtgctt ctgaaatctt ggatgagtga tagccgagaa aacccactga
    22141 tgatcttcca tctgttcaat gagatcatcg acattgtcaa acgttccaag gtaaaacttg
    22201 cagtgcccgt tgtagacgaa gtaaagctct aacatcactc cacctcaacg ggataaaaat
    22261 tcccaaagga acccctcaaa gccttaccaa cctgtacggc tgccccacga gaaacaaacc
    22321 gcatggcttt cttctcctct gaacatgaaa tgtccaagcc agtcacacca ataactacgg
    22381 acctcagaaa cggcttatcc tctcttgtcc catgtcttaa aataaacatc agccacctcc
    22441 attctaaaaa tattgcttcc gcttgtttgt caagtcgttg aaaaccatta aatggtcttt
    22501 atccacaccc ttcatcagtc tggacataaa gggtctgcca tatcttttct gaatatcagc
    22561 agaagtcaaa ttggtggtaa tgattgtatt tgaacgctta ttcaggatat tgtagagaat
    22621 agtaaacgac cattcgctat ccttttccat tcccaaatca tccaaaacca agaacttagc
    22681 actggcaatt ttattgacca gaaactcctc ctgactaaaa tcagctttaa tcttcatcaa
    22741 caagtccgtc acgttgatga agatagcaat ctctttcgtg tactcagata gagccttaac
    22801 catcgcaaag gccaaatggc tcttacctgt tccagcttct ccttgtaaca cgatgttgtt
    22861 cctagcaccc tcagaccact cacgacaaat cctctttgca aaaactagct tttctgcttc
    22921 tttttcagtt ggtgtttcaa aattgtccaa agtcgcattt ttcaaaacct catcataaag
    22981 agaaaacttc tcaagatagt atttcctctc tcgctcattc tcagcgtcgg ccaattcatt
    23041 cactcttgct tgattttcct catgaatccg ctcagattca cacatgcggc atacaacact
    23101 ctcagtccgc aatattttta tcaaaggaat attatgcttg tcgcaaagct ctttctgttg
    23161 ttctgtattc ctgtgataag ataaggcaat ttcatcaaac acattgtcta ccatgacaga
    23221 cgacctccgc attcatgcca gctagccatt tcagacaagc aagcaaccac ttgatgaatt
    23281 ggctggttgg ctaaaagagt tttcttctcg tagcttaacg gataatagtc aatctcgaat
    23341 tgctcaatta gttctaaaat ccccattcgt cccttacctc ctgttccgat gttttatcgt
    23401 tttgttgtcc tggacgactg taattctttc cctctttata tttttggtca ttctcatcta
    23461 cctgttcaat cgatgtaaaa cctttctttt tccaattctc aagaatgcct cttagatact
    23521 taaaactagg ttgatgaatc tccgaagtta tctcaattgc acggtttaac atatcaaaat
    23581 tcattccatc aattcctaca tattcaagca actgttgatg ttgtttatcg ttgattcgaa
    23641 taccactatg tttcaaattt tcagagaggc tggaactaat catcacctta ttatttttat
    23701 ctttctctat ctctttatct atatctatat ctccgttgca agttgttgcg atagtgttgc
    23761 aatgcaactt ttgtaattct ctgtgcttac gacttctacg agtactcgct gtttcactcc
    23821 caaccatctc aggaacctgt tctaagaaat aatcacggtt agagtttcta gtcagcaatc
    23881 ctttgctttc taaaaaaatc aatgtaattt taatatcttc aacattttcg tcaatgacaa
    23941 gagcgatttc ttcggctaga ttgtcagcaa gtccatcata gtaaatatgc cctccgtctt
    24001 ccaagctaat taacatcatt ttgagataaa tgatggtatg tgtatctccg ccagcaatct
    24061 tacgaagtag tttcatctcc tttgacttaa agaagtcctg agcaagctgg atccagaaat
    24121 accgcttgtt ttttaacgcc ataatctccc cccccacttc ctacggttag cgcggtactt
    24181 catccgcata tcctcataga tgtacctgcc ttccagctcc attttttcaa tctttagcag
    24241 cttattttta agctccacat cacgatagtc cttagctagt ttttcatagt ctgttaggta
    24301 ttctttgact agtaatagat ttttataatc gttttcccat atcgtaataa aatgtcttga
    24361 agttgattcc cttccttcca gtcctttaac aatcataatc aggttatcca gcgattcaat
    24421 caattcttcc atttcctgac ctcctcatta caaaaatctg attgcagact gtttaggttc
    24481 tggcaaagct aacagctcag ggcgcaatcc tacaggcggt tcgttgtcat atgtgaatcc
    24541 tttgaactct ctgcgaatat tcttgcgaat ttcttgccat ttgtcctctc taccacgttc
    24601 atatgcatga ttacgcactt ggataatcat agacgcaaat tcttgctctt ctcgtctttc
    24661 ttcttccttg cgttgttcct gcaatttgat atgacggcaa gcccctgcaa atccaagcag
    24721 taaggctcca acccccatca gctggtctaa aatcggtggt tcaaacattt ttatctcctt
    24781 atcctctttt tgtgctataa tatagtcaaa taattttgct aagaccttgt ccagaagcct
    24841 tttagtaaag ttattatatt tgattagaga gccattcttt gatggctctt tttgaccatt
    24901 tcttaccagg taattccttt ggaaatccct ttaagtaacg ataattatct gaaaaggtgg
    24961 catacttaat tcctagaaat tcgcaggtag tgttcacatc catcaactct ggatagtgat
    25021 cactatcttt ctctatttcg actagccttg tgattgtgtc cttgataata gatttaatcc
    25081 attcagacag tgaaagtaga acattgtcca tctttttccc tcctacactt cgtcaaatga
    25141 gttcaatttc atgattttca tcttagtatt ggtgcttggc tcccaagtca tccagtaagc
    25201 tagagcggca tccgcatgct tcttgggtag caaatcatag cgactaatgt tgaagtggtc
    25261 tttgaaatca atctcagctt gtctaaagac tgactgagcg aaagtcttat ccgcataagc
    25321 tggactatca ataccaccta agcaagccac gaccctagcc ttgcgcttct tcaatagcga
    25381 ctgagcatag cttggatgaa tcggttgctc actctttaga tagtcgatat cttccagcat
    25441 ggtagcctgt tgctcacgca atttcttctg gccagtgaat agagcaataa aggcatcctc
    25501 gtccaagtcc tcgcgaatga aaccgccctg cttgcgaata gctggcaaga cctctgatgt
    25561 cacccaacgt ttaaattctt tcgcttgtgg aagcttactt gaaagaatga gagagtagag
    25621 accagattcg ttgatgatga tagtgttttg tgttcgacct aaattgtcgg tgagtccgta
    25681 tttcacggag tcatcttcat caacgtgccg agaaattgcg tccagtggtt tagcatatcc
    25741 taagatatct gcaacatctt tcccaacgaa ccacggctca tcatcaattg tcaaagtacg
    25801 gacttcctgc ccgtgaaaat taaaaatttc gttcataata ttcctcttct tacttttcct
    25861 agtgttaaaa tagtttccca aacatctagt ccctcaagac tatcgatcat catctgacta
    25921 agttggtgat ttttcttctg ccaattcagt attattttcg cttgcatgta tggacctctc
    25981 agtgatttct ccaagggttt tcaataccca aaacatctgc aactttttcc ttaacagact
    26041 cactaccttt gccatacttc agcaactctg aaataactga tgatgttaca ggtacttgtt
    26101 ttgccaattc agcttgagtc atatccaact caatcaaacg agttttgatt ttagccttga
    26161 ttatctttag ttctttactc atatttttcc tttctatatt tctctgcttc ttttgaaatt
    26221 ttcaaaagca ttgaaagtcc cccaactact ccatctagat accctcgccc ataatctgtc
    26281 gctaagagtt ccaataattc tttcaggtct tcttcgttca tccctgacct ccttttaaaa
    26341 aattatctaa aaagttagcg aatttcttga catttttaaa taaatgattt aaaatcaaac
    26401 catagagaaa agacctacta aaagtaaggt tctacctaga aaaaacggac gccaatcagt
    26461 ttcattaggc tttatttttt agttgtctta ttcgctaact ctttagctta cgaatataat
    26521 tttaaattat ttatttaatt ttgtcaacaa ctttaattaa ataatttaat tattttttcg
    26581 taatgcttag aaaggttgat aaatcaatgt ttccaacata cgaaaaaatc aaagaacttg
    26641 caaaaaaaca gggactttct ataaatgctt tggaagaaaa gcttggatat agcagaaaca
    26701 cactatattc cctaaaaaaa caaaaagcta gtacagaaag aatgcaagaa atcgctgatt
    26761 actttaatgt atccttagac tacctgctcg gacgtacaga taatccagct atcgctggta
    26821 attcaaaaga gtacacatgg caagggaaga cactgaatgt tgaagaaatg gcatctaatg
    26881 tcatgatgtt tggtggccga gaattaacag atgaaaagaa gaaaatcatc cagtctatca
    26941 ttgaaggtta tctcaaagaa gctggtgatt agaggtactg cttagtgacc gaaaaagaaa
    27001 ttataagtca ttttcaggtt cgcattgtcg attttgacgg tgagctaata cctgatgaac
    27061 tcgggtttta cgaaaaagaa accaacacag ctttcttgtc taataaactc agtaaaaaag
    27121 agagagttaa ggtactactg catgaactcg gacacaaaga ccacacacgc tcagagtacc
    27181 agaacgctcg cttacgctgt gaaaacgaag ctgataggaa tatgatccat catctcgtaa
    27241 aagacgcact agaaagctta gatgacccca cagagtttga ttacctcaaa ttcatgtcct
    27301 attacaatct aaaaaccgtg acaaatgaaa tcatggtaaa agaagaatat aagtcactag
    27361 ttggataaag gagaaagtta tgaaaatagg aatgagaaaa ccaagtctga ccagaagttt
    27421 aaaagctaga actactagta aatggaaaag acaggctaaa aaagctatta tccctggcta
    27481 tggtaagaaa gggatgggat gggttaaaaa tccaaagaaa gctatgtata acaaggttta
    27541 tcataagaca acctttggac tttcggattt gtttaaatca tctaaaaagc gaaaaaagaa
    27601 agtagtcaac aacaaacagc aatctattct tgcctcgaac ggcaaaaagc aacacactcc
    27661 aaaagaatat aaagaagctg ggcttgtctt tatgttttta ggtgctatat tcctattttt
    27721 atttccacct ctcggcttct ttttgtttat tactggtttt ataacttaca ttattggtcg
    27781 tttaactgca aagcgagaga aaaagaagaa agttgaaaat tacagtccac agattgatac
    27841 aattgttttc cgagatgatt tcttattaat gggaacaaat tatcatcaag aagaagctga
    27901 gattgcagct gattttcttt ccaagggtgt ccattatttt gggaaagata ataagagttt
    27961 gaaatcttat atgcttgaaa catataaacc tgtttacaaa tacaataaat tgaaaacagt
    28021 agacgttcaa ctattaccag aaccttcaaa tccgcatgat aaaaatgctg tcaaagtttt
    28081 agtgaataat atctttgtcg gatacttacc agctatgatt gcaacacaag tttcatccta
    28141 catttctaat ccaaattaca gatatgatgc aatccttaca ggtagaggag gaccatataa
    28201 aaccctaaat atcgaaactg agagagtcgt ttctcgtaaa agtgacttaa cttactattt
    28261 agatttaaca gtatggcgtc ttgctaaaaa ataaaaaaaa cccacaatct ccctcgccaa
    28321 ggtttgattg tgaagctcac ccttataaaa aatcagccat taaaaaggcc tcttttctat
    28381 accctatttt acaccatgaa aggggtgatg tcaatattct caatgtttag accttgtcca
    28441 gaagctgata aacaaggaga atacaatgaa atataataaa acaaaatacc caaatatcta
    28501 ttactatgaa actgccaaag gcaagcgata ctatgtcaga cgttcttttt tcttccgagg
    28561 taaaaaaaga gaaaaaagta aaagtggtct cacaaccctt ccacaagctc gtgcagcctt
    28621 agtagagctt gagcaacaaa tccaagaaca agaattaggt atcaatacga atctgacact
    28681 tgatcaatat tgggatattt attctgaaaa gagattgtca acagggcgct ggaatgacac
    28741 ttcctactac ctcaatgata atctctacaa gaaccatatc aaggcaaagt ttggttctac
    28801 cctgcttaaa aatttggata gaaatgagta tgaactcttt atcgctgaaa agttgcagaa
    28861 ccataccaga tacactgttc aaaccctcaa ttccagcttc atggcattgc tgaatgatgc
    28921 cgtcaaaaat ggaaatctgc tctcaaatcg cttgaaaggt gttttcatcg gccagagtga
    28981 tatccctgct gcaaacaaga aagtgactct caaagagttc aagacttgga tagcaaaggc
    29041 agaagagatt atgccaaaac aattctacgc tctgacctat ctgacaattt ttggattgag
    29101 aagaggagaa gtctttggat tgcgtccaat ggacatcact cagaacgaca gcggacgggc
    29161 tatactgcat cttagagaca gtcgaagcaa ccagacctta aaagggaaag gagggcttaa
    29221 aacgaaggat tcagagcgat atgtctgcct tgatgatatc ggaacagacc tgatctatta
    29281 tctgatagct gaagcttcta agattaagcg aaagttagga attatcaagg aacagcacaa
    29341 ggattatata actatcaacg agaaaggtgg tctcatcaat ccaaatcagc taaatagaaa
    29401 cttcaatcta gtgaatgaag caacaggatt gcatgtaaca cctcacatga tgcgccactt
    29461 cttcacgact caaagcatta ttgcaggggt tccgcttgaa caattaagcc aggcgctggg
    29521 gcatacaaag gtttatatga cggatcgtta caatcaagta gaggacgaac ttgctgaagc
    29581 gacaacagac ctatttctta gtcatattcg ctaaaaaagt ccccgccaat tccccgacca
    29641 aaatccgaaa aataccgaaa aatatcgaaa aattattttt agaatagtcc ccaaaagcct
    29701 gaaataaagc taaaaaac
//
LOCUS       DAVHSO010000024        28959 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.024, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000024 DAVHSO010000000
VERSION     DAVHSO010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 28959)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 28959)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..28959
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.024"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..551
                     /locus_tag="VVR18_001046"
     CDS             <1..551
                     /locus_tag="VVR18_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU6032593.1"
                     /translation="KCDGKKAENLIQGQFEGSKTMEKCYTDVTEFAIPASTQKLYLSP
                     VLDGFNSEIIAYNLSTSPNLEQVQTMLEQAFTEKHYENTILHSDQGWQYRHDSYHRFL
                     ESKGIQASMSRKGNSQDNGRMESFFGILKSEMFYGYEKSFQSLKQLEQAIVDYIDYYN
                     NKRIKVKLKGLSPVQYRTKSFE"
     gene            complement(679..1701)
                     /gene="cbpF"
                     /locus_tag="VVR18_001047"
                     /pseudo
     CDS             complement(679..1701)
                     /gene="cbpF"
                     /locus_tag="VVR18_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771060.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpF"
     gene            complement(1720..2545)
                     /gene="cbpG"
                     /locus_tag="VVR18_001048"
                     /pseudo
     CDS             complement(1720..2545)
                     /gene="cbpG"
                     /locus_tag="VVR18_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001100143.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpG"
     gene            complement(2626..2865)
                     /locus_tag="VVR18_001049"
     CDS             complement(2626..2865)
                     /locus_tag="VVR18_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032594.1"
                     /translation="MKKTVYKKLGISIIASTLLASQLSTVSALSVISSTGEEYEVSET
                     LEKGPESNDSSLSEISPTYGSYYQKQSEVLSVMMI"
     gene            complement(3015..3281)
                     /locus_tag="VVR18_001050"
                     /pseudo
     CDS             complement(3015..3281)
                     /locus_tag="VVR18_001050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060522.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            complement(3306..3617)
                     /locus_tag="VVR18_001051"
     CDS             complement(3306..3617)
                     /locus_tag="VVR18_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002877158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HEU6032595.1"
                     /translation="MDWDFADTCWEKEPRKYQYVAANYLKAMQSYLKETDLPKLEQLV
                     VTKSWWDTVDILDRVVGSLVYKHPELEEIILIFFENLFKPRQLYLQPQNSVLSNLRLA
                     S"
     gene            complement(3542..3773)
                     /locus_tag="VVR18_001052"
                     /pseudo
     CDS             complement(3542..3773)
                     /locus_tag="VVR18_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812384.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            complement(3774..4406)
                     /locus_tag="VVR18_001053"
     CDS             complement(3774..4406)
                     /locus_tag="VVR18_001053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032596.1"
                     /translation="MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALE
                     LRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIVTSYLDNEKIMPVLDAGAKGYML
                     KTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
                     ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF"
     gene            complement(4420..5415)
                     /locus_tag="VVR18_001054"
     CDS             complement(4420..5415)
                     /locus_tag="VVR18_001054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU6032597.1"
                     /translation="MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEK
                     FVFLLLVFSMSLTCLLALFWRGIEELSLRKMQANLKRLLAGQEVVQVVDPDLDASFKS
                     LSGKLNLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
                     QALKLDREKMQIQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELED
                     KSDLRVSLKQNMTKLPKKIEEHIFRILQELISNTLRHAQASCLDVYLYQTDVELQLKV
                     VDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLAVDIRIPLLDKE"
     gene            complement(5412..6110)
                     /locus_tag="VVR18_001055"
     CDS             complement(5412..6110)
                     /locus_tag="VVR18_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-active antibiotics response protein"
                     /protein_id="HEU6032598.1"
                     /translation="MRKFKIFLFIEACLLTGALILMVSEHFSRFLLILFLFLLLIRYY
                     TGKEGNNLLLVAVTILFFFIVMLNPFVILAIFVAVIYSLFLLYPMMNQEKEQTNLVFE
                     EIVTVKKEKNRWFGNLHHFSSYQTCQFDDINLFRFMGKDTIHLERVILTNHDNVIILR
                     KMVGTTKIIVPVDVEVSLSVNCLYGDLTFFNQPKRALRNEHYHQETKDYLKSNKSVKI
                     FLTTMIGDVEVVRG"
     gene            complement(6188..7198)
                     /locus_tag="VVR18_001056"
     CDS             complement(6188..7198)
                     /locus_tag="VVR18_001056"
                     /EC_number="5.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="HEU6032599.1"
                     /translation="MTTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLS
                     TEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAESCGILFVTGSYSAALKNPTDDS
                     FSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRS
                     WQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRR
                     SGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRT
                     VLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEANDQMK
                     KA"
     gene            complement(7182..8189)
                     /locus_tag="VVR18_001057"
     CDS             complement(7182..8189)
                     /locus_tag="VVR18_001057"
                     /EC_number="2.7.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000562378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomevalonate kinase"
                     /protein_id="HEU6032600.1"
                     /translation="MIAVKTCGKLYLAGEYAILEPGQLALIKDIPIYMRAEIAFSDSY
                     RIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLEICGKMEREGKKF
                     GLGSSGSVVVLVVKALLALYNLSVDQNLLFKLTSAVLLKRGDNGSMGDLACIVAEDLV
                     LYQSFDRQKVAAWLEEENLATVLERDWGFFISQVKPTLECDFLVGWTKEVAVSSHMVQ
                     QIKQNINQNFLTSSKETVVSLVEALEQGKAEKVIEQVEVASKLLEGLSTDVYTPLLRQ
                     LKEASQDLQTVAKSSGAGGGDCGIALSFDAQSTETLKNRWADLGIELLYQERIGHDDK
                     S"
     gene            complement(8176..9129)
                     /gene="mvaD"
                     /locus_tag="VVR18_001058"
     CDS             complement(8176..9129)
                     /gene="mvaD"
                     /locus_tag="VVR18_001058"
                     /EC_number="4.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000373478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="HEU6032601.1"
                     /translation="MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYT
                     ETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAA
                     GLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
                     YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLK
                     ENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMD
                     AGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC"
     gene            complement(9111..9989)
                     /gene="mvk"
                     /locus_tag="VVR18_001059"
     CDS             complement(9111..9989)
                     /gene="mvk"
                     /locus_tag="VVR18_001059"
                     /EC_number="2.7.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mevalonate kinase"
                     /protein_id="HEU6032602.1"
                     /translation="MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVP
                     AESPWRLYEEDTLSMAVYASLEYLDITEACIRCEIDSAIPEKRGMGSSAAISIAAIRA
                     VFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
                     SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQI
                     LSQAHLHLKEIGVSSPEADFLVETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELA
                     ERLEEKGAVQTWIESL"
     gene            complement(10111..10440)
                     /locus_tag="VVR18_001060"
     CDS             complement(10111..10440)
                     /locus_tag="VVR18_001060"
                     /inference="COORDINATES: protein motif:HMM:NF024736.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6032603.1"
                     /translation="MTRKAYDTDLNDQEWAKIEPYFSKHRTYKWPKRVLVNETLYVTK
                     TGCQWRMIPHDFPLYLTVWSFFRRSMTTGWFQVNGRWYYAYSSGALAVNTTVDGYFVN
                     YNGEWVQ"
     gene            11103..11441
                     /locus_tag="VVR18_001061"
     CDS             11103..11441
                     /locus_tag="VVR18_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic-modifying protein"
                     /protein_id="HEU6032604.1"
                     /translation="MTIRTTHTYEYQYSLLFGDAGYLWLLLHLFSISKNQYYLQLANV
                     TAKKLIENYDTLEEIDFALGKSGVLLSLIKYYQFTNDNTLKTFIHNSIWGNLSLFPTK
                     RYSQRKHFRL"
     gene            11341..11811
                     /locus_tag="VVR18_001062"
     CDS             11341..11811
                     /locus_tag="VVR18_001062"
                     /inference="COORDINATES: protein motif:HMM:NF017000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032605.1"
                     /translation="MTILLKLSSTIVYGEIYHYFLQRDTAKESILDYSFAHGYCEIAY
                     ALFAYSKVLEPSMFYNDLHTFHAELKKLLEKVTSNTENLGNLQLSWCEGISGIILYLC
                     MYDCDGNKDIISKYQEFVFNHHLKMMTGYCHGITSLLQTTVYNQNKLLMKKSNR"
     gene            11970..13202
                     /locus_tag="VVR18_001063"
     CDS             11970..13202
                     /locus_tag="VVR18_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6032606.1"
                     /translation="MKLFWTNNIYRQLLLNSCFSSFGDSIFYLAIINYVAQYNFAPLA
                     ILLISISEMVPLLSQLFLGILGDFQENRVKHALWIAKIKILLYAILTVFLVLSPFSLV
                     SVIMIVIINLISDTLSYLSAYMMNALYISVIKDDLHDAMGFRQSLMRVVHIVANLAGA
                     FLINVMSIQTISLINTLTFVIAFLGLYVIRHTLYEVEKRIEMSHTALSFKKYFQHLKQ
                     SLAVLLRLKDTVILLFLTTSMIAILDVSPRLIALRFIQQTLAQLSIGQLLALLSIIMS
                     CGAILGNMTSSNLFKNIRFTHLLVFCEISLLTLITSILCQAYIVIFMTSFISSTIIGI
                     LSPRLQAAVFAHIPSDKMGTVGSALSTVDILAPSLLSLLALSIASGVSVQLASIFLYL
                     ILIALIFCQWLVKFNTHN"
     gene            complement(13320..14276)
                     /gene="cbpC"
                     /locus_tag="VVR18_001064"
     CDS             complement(13320..14276)
                     /gene="cbpC"
                     /locus_tag="VVR18_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpC"
                     /protein_id="HEU6032607.1"
                     /translation="MKLLKKMMQVLLAVFFFGLLATNTVFANTTGGRFVDKDNRKYYV
                     KDDHKAIYWHKIDGKTYYFGDIGEMVVGWQYLEIPGTGYRDDLFDNRPVFEIGLQEKW
                     YYFGQDGALLEQTDKQVLEAKTSENTGKVYGEQYPLSAEKRTYYFDNNYAVKTGWIYE
                     EGHWYYLNKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDASGKML
                     TDWQKVNGKWYYFGSSGSMATGWKYVRGKWYYLDNKNGDMKTGWYQDGSTWYYLNTSN
                     GDMKTGWFQVNGNWYYAYSSGALAVNTTVDGYYVNYNGEWVR"
     gene            complement(14374..15063)
                     /locus_tag="VVR18_001065"
     CDS             complement(14374..15063)
                     /locus_tag="VVR18_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000518023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032608.1"
                     /translation="MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQ
                     TDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMILDHWEDLQEELEVVQRFAVSYIY
                     KPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
                     REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIK
                     TVRGVGYTMQE"
     gene            complement(15075..16499)
                     /gene="gndA"
                     /locus_tag="VVR18_001066"
     CDS             complement(15075..16499)
                     /gene="gndA"
                     /locus_tag="VVR18_001066"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="HEU6032609.1"
                     /translation="MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIA
                     CHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGN
                     TFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEIS
                     AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAE
                     IFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDL
                     GVPLSLITESVFARYISTYKEERVYASKVLPKPAAFNFEGDKAELIEKIRQALYFSKI
                     ISYAQGFAQLRVASKENNWNLPFAYIASIWRDGCIIRSRFLQKITDAYNRDADLANLL
                     LDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRD
                     YFGAHTYQRKDKEGTFHYSWYDEK"
     gene            complement(16575..17969)
                     /gene="mapZ"
                     /locus_tag="VVR18_001067"
     CDS             complement(16575..17969)
                     /gene="mapZ"
                     /locus_tag="VVR18_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mid-cell-anchored protein MapZ"
                     /protein_id="HEU6032610.1"
                     /translation="MSKKRRNRQKKEGQEPQFDFDEAKELTVGQAIRKNEEVEAGVLP
                     EDSILDKYVKQHRDEIEADKFATRQYKKEEFVETQSLDDLIQEMREAVEKSEASSEEV
                     PSSEDILLPLPLDDEEQGLDPLLLDDENPTEMTEEVEEEQNLSRLDQEDSEKKSKKGF
                     ILTVLALVSVIICVSAYYVYRQVARSTKEIETSQSTTANQSDVDDFNTLYDAFYTDSN
                     KTALKNSQFDKLNQLKTLLDKLEGSREHTLAKSKYDSLATQIKAIQDVNAQFEKSAIV
                     DGVLDTNAKAKSDAKFTDIKTGNTELDKVLDKAISLGKSQQTSTSSSSLSQTSSSSSS
                     QASSNTTSEPKPSSSNETRSSRSEVNMGLSSAGVAVQRSASRVAYNQSAIDDSNNSAW
                     DFADGVLEQILATSRSRGYITGDQYILERVNIVNGNGYYNLYKPDGTYLFTLNCKTGY
                     FVGNGAGHADDLDY"
     gene            complement(17981..19138)
                     /locus_tag="VVR18_001068"
     CDS             complement(17981..19138)
                     /locus_tag="VVR18_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HEU6032611.1"
                     /translation="MKKEFNLIATVAAGLEAVVGREVRELGYDCQVENGRVRFQGDVR
                     AIIETNLWLRAADRIKIIVGTFPAKTFEELFQGVFALDWENYLPLGARFPISKAKCVK
                     SKLHNEPSVQAISKKAVVKKLQKHYARPEGVPLMENGPEFKIEVSILKDVATVMIDTT
                     GSSLFKRGYRTEKGGAPIKENMAAAILQLSNWYPDKPLIDPTCGSGTFCIEAVMIARK
                     MAPGLRRSFAFEEWNWISDRLIQEVRTEAAKKVDRELELDIMGCDIDARMVEIAKANA
                     QVAGVAGDITFKQMRVQDLRSDKINGVIISNPPYGERLSDDAGVTKLYAEMGQVFAPL
                     KTWSKFILTSDEAFESKYGSQADKKRKLYNGTLKVDLYQYFGQRVKRQEVK"
     gene            complement(19223..19603)
                     /gene="rnpB"
                     /locus_tag="VVR18_001069"
     ncRNA           complement(19223..19603)
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="VVR18_001069"
                     /product="RNase P RNA component class B"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00011"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00011"
     gene            complement(19624..19953)
                     /gene="gpsB"
                     /locus_tag="VVR18_001070"
     CDS             complement(19624..19953)
                     /gene="gpsB"
                     /locus_tag="VVR18_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division regulator GpsB"
                     /protein_id="HEU6032612.1"
                     /translation="MASIIFSAKDIFEQEFGREVRGYNKVEVDEFLDDVIKDYETYAA
                     LVKSLRQEIADLKEELTRKPKPSPVQAEPLEAAITSSMTNFDILKRLNRLEKEVFGKQ
                     ILDNSDF"
     gene            complement(20023..20550)
                     /locus_tag="VVR18_001071"
     CDS             complement(20023..20550)
                     /locus_tag="VVR18_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1273 domain-containing protein"
                     /protein_id="HEU6032613.1"
                     /translation="MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVS
                     WLVFTGSLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEGNQMKLSRFKQVDF
                     VKYAYPRYEHKGQLRDYQQFLLENTTSSYLFYDEENETKLAYFYQKMKNQEDYFIKRL
                     TFDQLNELAENFSEN"
     gene            20616..21212
                     /gene="recU"
                     /locus_tag="VVR18_001072"
     CDS             20616..21212
                     /gene="recU"
                     /locus_tag="VVR18_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RecU"
                     /protein_id="HEU6032614.1"
                     /translation="MVNYPHKVSSQKRQTSLSQPKNFANRGMSFEKMINATNDYYLSQ
                     GLAVIHKKPTPIQIVQVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEVKETKQ
                     KRAIPMKNFHPHQIQHMEQVLAQQGICFVLLHFSSQQETYLLPAFDLIRFYHQDKGQK
                     SMPLEYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR"
     gene            21209..23368
                     /locus_tag="VVR18_001073"
     CDS             21209..23368
                     /locus_tag="VVR18_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001040003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 1A"
                     /protein_id="HEU6032615.1"
                     /translation="MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSE
                     SKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGID
                     TIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQK
                     ATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDP
                     YSHPEAAQDRRNLVLSEMKNQGYISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYL
                     KEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIV
                     DVSNGKVIAQLGARHQSSNVSFGINQAVETNRDWGSTMKPITDYAPALEYGIYDSTAT
                     IVHDEPYNYPGTNTPVYNWDRGYFGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLN
                     GLGIDYPSIHYSNAISSNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFS
                     DGSEKEFSNVGTRAMKETTAYMMTDMMKTVLTYGTGRNAYLAWLPQAGKTGTSNYTDE
                     EIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAKVYRSMMTY
                     LSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWNSPAPQQPPSTESSSSSSDSSTSQSS
                     STTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP"
     gene            complement(23535..28838)
                     /locus_tag="VVR18_001074"
     CDS             complement(23535..28838)
                     /locus_tag="VVR18_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032503.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEU6032616.1"
                     /translation="MNKGLFEKRCKYSIRKFSLGVASVMIGAAFFGTSPVLADSVQSG
                     STANLPADLATALATAKENDGRDFEAPKVEEDQGSPEVTDGPKTEEELLALEKEKPAE
                     EKPKEDKPAAAKPETPKTVTPEWQTVEKKEQKGTVTIREEKGVRYNQLSSTAQNDNAG
                     KPALFEKKGLTVDANGNATVDLTFKDDSEKGKSRFGVFLKFKDTNNNVFVGYDKDGWF
                     WEYKSPTTSTWYRGSRVVAPETGSTNRLSITLKSDGQLNASNNDVNLFDTVTLPAAVN
                     DHLKNEKKILLKAGSYGNDRTVVSVKTDNQEGVKADDTPAQKETGPVVDDSKVTYDTI
                     QSKVLKAVIDQAFPRVKEYTLNGHTLPGQVQQFNQVFINNHRITPEVTYKKINETTAE
                     YLMKIRDDAHLINAEMTVRLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERKLLSSISF
                     LGNALVSVSSDQTGAKFDGATMSNNTHVSGDDHIDVTNPMKDLAKGYMYGFVSTDKLA
                     AGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKE
                     LPSAKVVITEDANADKKVDWQDGAIAYRSIMNNPQGWEKVKDITAYRIAMNFGSQAQN
                     PFLMTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIE
                     KAKKYGAHLGIHVNASETYPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDAAYDLA
                     HGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGDNGAWATHVLAKEINKQGWRFAIEWG
                     HGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLL
                     GGYSMKDFEGWQGRSDYNGYVTNLFAHDVMTKYFQHFTVSKWENGTPVTMTDNGSTYK
                     WTPEMRVELVDADNNKVVVTRKSNDVNSPQYRERTVTLNGRVIQDGSAYLTPWNWDAN
                     GKKLPTDKEKMYYFNTQTGATTWTLPSDWAKSKVYLYKLTDQGKTEEQELTVKDGKIT
                     LDLLANQPYVLYRSKQTNPEMSWSEGMHIYDQGFNSGTLKHWTISGDASKAEIVKSQG
                     ANDMLRIQGNKEKVSLTQKLTGLKPNTKYAVYVGVDNRSNAKASITVNTGEKEVTTYT
                     NKSLALNYVKAYAHNTRRDNATVDDTSYFQNMYAFFTTGSDVSNVTLTLSREAGDQAT
                     YFDEIRTFENNSSMYGDKHDTGKGTFKQDFENVAQGIFPFVVGGVEGVEDNRTHLSEK
                     HDPYTQRGWNGKKVDDVIEGNWSLKTNGLVSRRNLVYQTIPQNFRFEAGKTYRVTFEY
                     EAGSDNTYAFVVGKGEFQSGRRGTQASNLEMHELPNTWTDSKKAKKATFLVTGAETGD
                     TWVGIYSTGNASNTRGDSGGNANFRGYNDFMMDNLQIEEITLTGKMLTENALKNYLPT
                     VAMTNYTKESMDALKEAVFNLSQADDDISVEEARAEIAKIEALKNALVQKKTALVADD
                     FASLTAPAQAQEGLANAFDGNVSSLWHTSWNGGDVGKPATMVLKEPTEITGLRYVPRG
                     SGSNGNLRDVKLVVTDESGKEHTFTATDWPDNNKPKDIDFGKTIKAKKIVLTGTKTYG
                     DGGDKYQSAAELIFTRPQVAETPLDLSGYEAALAKAQKLTDKDNQEEVASVQASMKYA
                     TDNHLLTERMVEYFADYLNQLKDSATKPDAPTVEKPEFKLSSLASEQGKTPDYKQEIA
                     RPETPEQILPATGESQSDTALFLAGVSLALSALFVVKTKKD"
BASE COUNT         8358 a         6608 c         5192 g         8801 t
ORIGIN      
        1 taaaatgtga cggcaagaag gcagagaatc tcattcaagg ccaatttgaa ggctctaaaa
       61 caatggaaaa gtgctacaca gatgtgacag aatttgccat tccagcaagt actcaaaagc
      121 tttacttatc accagtttta gatggcttta atagcgaaat tatcgcctat aatctttcaa
      181 cttcacccaa cttagaacaa gtacaaacaa tgttggaaca ggcattcaca gaaaagcact
      241 atgagaatac gattctccat agtgaccaag gctggcaata ccgacacgat tcttatcatc
      301 ggttcctaga gagtaaggga attcaagcat ctatgtcacg caagggaaac agccaagaca
      361 acggtaggat ggaatctttc tttgggattc tgaaatcgga aatgttttac ggttatgaga
      421 agtcgtttca gtcgcttaag caattggaac aagctattgt agactatatt gattactaca
      481 acaacaagag aattaaggta aaactaaaag gacttagtcc tgtgcagtac agaactaaat
      541 cctttgaata aattatttgt ctaacttttt gggggcagta cattgttaac ttgatactat
      601 gcgttttttg attgtgaaga cttttatcca cctattatac aaagtcaagt atccatcaca
      661 gtttacaatt agccttcatt acttaaccca ttcaccatta tagtttaagt agtaaccacc
      721 tactgtggta ttaacagcta aagcacctga atcataggca tagtaccagt taccattgac
      781 ttggaaccag cctgttttca tatctccatt acttgcattt agatagtacc aagtcgaacc
      841 ttcctgatac caaccagttg ccatagctcc tgatgaacgg agatagtacc atttgttccc
      901 aaggttttgc caaccagttt tcatatcgcc attttcagca tctaaatagt accaagttga
      961 accatcttga taccagccag ttgccatagc tcctgatgaa cggagatagt accatttatt
     1021 accaagatgt tgccaacctg tttgcatgat gccagttgct ggatctaggt agtaccatgg
     1081 agcaggtttg agcttctctt catcataggt aagagggtaa tccttaaccc aaccacgtgc
     1141 tagctctcca accgtcaatc tgttgatgcg agaatcaaag ccaccatcct tctgcaaata
     1201 ataccagtcc ccatcatcat aaacccaacc agtttttaaa gtatgataac tacgctgatc
     1261 ttcaaaataa tagattcgtt tctctgctgg gctatcatat tcttccccat gatgtttgtt
     1321 ggtatttgta gcagtttttg cttctaaaac ttgcttgcca acaaattatt gtaatacacc
     1381 atcttgacca aaataaaacc aatctggtct aagagcaatc tctattcttg gagaaggacc
     1441 aatcgtaacc cccttgtgtg gagcaggtat atattgccag ccgacaacca tctctccgga
     1501 taaaggatca aaataatagt atttcccatc tatcactctc cagtaggttt cttttagatc
     1561 cccctttttg tagtaggttc taccattttc ttggacaaac tgccatcctt cagaatcatc
     1621 tgcaaatact gtactggtcc ctagcaaacc gaagaaaaat gtggctagta cgacttgcat
     1681 cattttttta aaaagcttca ttttatatat cctccaacat caaatccact caccagatga
     1741 agcgaagtta taaactttac catcgatagt ttggctacct gtaaccattg ctctatttga
     1801 attgagataa taccattttc catttacttt ttgccaatct gtaagcatct taccggaact
     1861 gtctaaataa taccaagtat catttatctc ctgccaaccc gtttgtttat catgttgtct
     1921 ataatagtac caactaccat ttattttctt ccatccttca agagagtaac ctttaagaac
     1981 cgaataaata aataaatggc aaatttcgtt catttaattt aactgcactg ttaatttgat
     2041 tagctccatc tcctaaagta tgcactccta ctacgcggtg actagcatca taaactgcag
     2101 atccactaga cccctctaaa gtatcaactt ggtaatccaa gaacatgcca tcatcactta
     2161 aaacttgttt tttatctgta tacatttgat gaattttaaa attatatgat agatagcctg
     2221 tgatagtcac agttattcct gtcaaatttt tttgactagt aggaagaccc aaagtcccta
     2281 attttgcacc aatgggctct tctagaatta ataaagccaa gtcatattcc cttgcattct
     2341 tagaatttaa atttctaaat tccttcaaat aacgaacttc ctttactttg atctttccaa
     2401 atagttcttg acttggacta acagccggaa gaacataaat atcatccgct tctttcccat
     2461 agtcatgtct gtagtagttg tgagccgctg taattaacac attatcttta ataaaattcg
     2521 cacttcccct cccttctaca ttcattccat cggctactcc ataatactta gataaaacca
     2581 tagctgaagt cgaatacgga tactgtaaag tattatcaat tttaatcaaa tcatcattac
     2641 cgataatact tctgattgct tttggtagta tgaaccatac gttggtgaaa tctcagataa
     2701 tgaagaatca ttagactctg gacctttttc tagtgtctca cttacctcat attcttcacc
     2761 tgtactagaa ataacactca aagcagatac tgtcgataac tggctagcca ataaagtact
     2821 cgcaataatt gaaataccca attttttata aacagttttc ttcattatcg tatcctccta
     2881 atgtaattat agcgtactat tctaaatttc tcaatctact atagaatcaa gaaatctacc
     2941 accttcttta aataccctcc attatcacat aaacaggtaa acttttcaat taatgactgc
     3001 gcttttcaat cacgctagag gtacttgctt gcttctttga tactaagttc agccattctt
     3061 tccttgtttt tctcaataaa gcatgttacc caagtgggat tcgttttgga gtagtctcgc
     3121 agagtccagc caatggcttt attgataaaa aattctgttt ggttcaagtt atgaaggaga
     3181 atcttttcca ttaattgagt attggtcttc tcttttctta acaactggtg gtcaatagcg
     3241 acacgtctca gccagatatt atctgatagg ctccatttta tactcaatga aaatcaaaga
     3301 gcaaactagg aagctagccg cagattgctc aaaacactgt tttgaggttg cagatagagc
     3361 tgacgtggtt tgaagagatt ttcgaagaat attaagatta tttcttctag ttcagggtgt
     3421 ttatacacca aactccctac tactcgatct aggatatcta ccgtgtccca ccaggatttt
     3481 gtcacgacta actgctctag cttaggcaaa tcggtttcct ttagataaga ctgcattgct
     3541 ttcaaatagt tagcagccac atattggtat tttctaggct ccttttccca gcaagtgtct
     3601 gcaaaatccc aatcgataat ctttgttttt ttcgcttctg gaaaatattt ttatagagtt
     3661 tatttctttc aacctagaaa agaaaattga tggcgcatat aggcttccat gggccttgct
     3721 tttttagagt cttttgctgc ttctagctcc tcaagtaaat ctgctaaacc catctaaaac
     3781 tcctcttgcc ccaccaaatg gtgctgaaag gcgtagacag ccgcctgggt acgatcactg
     3841 acttcaagtt tggcaagaat gttggacacg tgggtcttga ccgtcttgag agagataaag
     3901 aggtcatctg cgatgcgctg attttcgtag cccttggcga tgagttggag aacatctcgc
     3961 tcacgcgcag tcaattcttc atgaagttcc atatgattgc ggtggtattc aaccttcttg
     4021 ctaacctctt gctcaatggc cagctcgcca gcagctacct tactgacggc atgaagcaat
     4081 tcatctgcac tagaagtctt gagcatatag cctttggcac cagcatctaa gactggcatg
     4141 attttttcat tgtccagata agaggtcaca atcaaaatct tggcttcagg ccattcttta
     4201 aggattgcta aggtcgcgtc aatcccattc atctcaggca tgacaatatc catgacaatg
     4261 acatctggac gcagttccaa ggccaagtca atcccttgag acccgttgga cgcctcaccc
     4321 acaacttcta catcgtcttg gaggtcaaag tagcttttca agcccaatcg gaccatttca
     4381 tggtcatcta ctagtaaaat tttcatcttt actcctttat cattccttat ctaacagggg
     4441 aatacggata tcaaccgcca gcccttgctt gggagctgtc aagagttgaa ctgttccagc
     4501 catatcttca acccgctcct tgatatttcg cagtccataa ctcaagtcgt ctaagctccc
     4561 taactggaaa ccaatcccat tgtccaccac cttcagttgc aattcaacat ctgtctgata
     4621 gaggtagaca tctaggcaag atgcctgggc atggcggagc gtattgctaa tcaactcttg
     4681 caggatacgg aagatatgct cctcgatttt cttaggcaat ttcgtcatat tctgcttgag
     4741 actaacccta agatcactct tgtcctcaag ctcttttaag agaatttgaa tcccttctat
     4801 caagctcttc tgctccagtt caactggtcg caaatgcaag agcaaaaccc gcaaatcctt
     4861 ctgggcagtt tctaaaatag ctgtgacact ctgcaactgg atctgcatct tttctctatc
     4921 taatttcaaa gcctgctgac tgatacccga taaaatcatg tgggccgcaa acaactcctg
     4981 actgactgta tcgtgcaaat cccgagcaat tcgcttccgt tctttctcga tgatttcctc
     5041 ttcctgagca aggctatgat tttcagcttt ttgaagagct tctgtcaaaa ggttaagttt
     5101 acctgataag gacttgaaac tggcatccaa atctggatct acaacctgaa ctacttcttg
     5161 ccctgccaat aaacgcttga gattggcctg catttttctt agagaaagct cttcgatccc
     5221 tcgccaaaac agggctaaga gacaggtcag ggacatgctg aaaaccaaca ataaaaagac
     5281 aaatttttct gttttttcga catcgtgcaa aaagatagac cagtcaaaat caagtatttc
     5341 cagcaagcta tgggagaaaa aaaagacaaa caggaaggag gtgagagcga taatgacata
     5401 ggcttgtttt ttcatcctct aaccacctcc acatcaccaa tcatagtggt caagaaaatc
     5461 ttgacactct tgttactctt gagatagtct tttgtttctt gatgatagtg ttcattgcgg
     5521 agggctcgct tgggctggtt gaaaaaagtc aaatccccat agagacagtt aacgctgaga
     5581 ctgacttcca catctacagg tacgatgatt ttggtcgttc ctaccatctt tctgaggata
     5641 atgacattgt catgattggt taagatgacc ctctccagat gaatagtgtc cttgcccatg
     5701 aagcgaaaga gattgatatc atcgaattgg caagtctggt agcttgaaaa atgatgaaga
     5761 tttccaaacc aacgattttt ctccttctta accgtcacga tctcttcaaa aaccaaattg
     5821 gtctgctctt tttcctggtt catcatcggg taaagaagaa agaggctata gataaccgca
     5881 acaaaaatag ctagaatcac aaaaggattg agcataacga tgaaaaagaa gagaatggtt
     5941 accgctacta aaagaagatt atttccctct ttaccagtgt agtagcgaat caaaagcaaa
     6001 aagaggaata gtatcagcag aaaacgcgaa aaatgctctg ataccatcaa aatcagagct
     6061 cctgtcagaa gacaggcttc gataaataaa aagattttaa attttctcat aggttcatcc
     6121 tctcccttct attttatcac aattcaaaaa agtcacctca gtctgaggat ggaaaaaaag
     6181 gcgctggtta cgcctttttc atctgatcat ttgcttcttt taattttcca taaagaagat
     6241 agtctacttt ttgtagatct gctatggtgg cacagttaag ggaacacata atcaagcgta
     6301 gatctgcttt ccagccttga acaatgccaa tcacttcttc aactgtgtag gtttcaacca
     6361 attccagaac ggttcgtgac aatcccacag ccttagcacc aaaaaccaag cacttaatca
     6421 tatccagcgg attccgaacc cctccactaa ccaagagttc gaccttatct ttccattctt
     6481 gggcattgag aagggcctgc atggtagact gaccccattg attgaggtaa tcacgctggc
     6541 cactacgacg gttttcgata taggcaaagc tggtgccacc acgacccgat aggtccactg
     6601 tacgaacacc gaattcatag gctctttcga ttgtcttggc atccattcca aagcccactt
     6661 ccttgaggac aataggaacg ggaatttgct tgctataatc tgctagatgc gattgccagc
     6721 ttctaaactt cctttctccc tcgggcatga gtaattcctg catgacattg acatgcactt
     6781 gcaatagaac aggattcatc tcttctacag tctgaagccc taactcgaca ggcttgtcca
     6841 atccaatatt ggttccaagg aggagattgg gatgactaga cttgacagaa aaagaatcat
     6901 ccgttggatt tttgagggct gcgctataag aacccgttac aaataaaata ccacaggatt
     6961 ccgccacctg agccagcttt tgattgattt ctcttccctt attacttcca ccagtcatgg
     7021 cattgatata aaaaggaaag tcccactttc gaccagcaaa ctctgtcgaa agatcgattt
     7081 catccagatt gtaaagaggc aaggaagaat gaatcagctc cacctcatca aagctattat
     7141 aggaactttt ctgctcaagg gcatagagga tatgctcgtc cttacgattt gtcgtcatgt
     7201 cctatccttt cttgatataa gagctcaatc cccagatcgg cccaacgatt ttttaaggtt
     7261 tcggttgatt gcgcatcaaa actcagggcg atgccacagt caccaccacc agcaccacta
     7321 ctcttggcaa cggtctgcaa atcttgactg gcttctttca actgtctaag caaaggcgtg
     7381 taaacatctg tactcaagcc ttctaaaagc ttgctggcta cttctacttg ctcgataact
     7441 ttttcggctt tcccctgctc caaggcttcg accaaagaaa ccaccgtttc ttttgaggaa
     7501 gttaaaaaat tttgattgat attttgcttg atttgctgga ccatgtgact cgatacagcc
     7561 acttccttgg tccatcccac taagaaatca cattctaaag ttggtttcac ttgtgagata
     7621 aaaaatcccc aatcacgctc cagaactgtc gccaagtttt cttcttctaa ccaagcagcc
     7681 accttctggc gatcaaatga ctggtagaga accaaatcct ctgccacaat acaggcaagg
     7741 tcgcccatgg aaccattgtc tcctcgcttg agcaagacag cgctagtcag cttgaacaag
     7801 agattctgat caaccgaaag attatagaga gccagtaaag ccttgacaac caagacaacg
     7861 acgctgccac tagaacctag accaaacttt ttcccttctc gttccatttt gccacagatt
     7921 tctagagaaa aaggtcttaa attctgacca cgaacagcga ggaagtctcc catcaaagca
     7981 atcgtttctt gaatcaagct atagtcagga ttgggcctta agtccactgc gaaatcaaac
     8041 atatctgaat agatacggta gctatcagaa aaagcaatct cagccctcat atagatggga
     8101 atatccttta tcaaagctaa ctgccctggc tctaaaatag catattcacc tgccaaatag
     8161 agttttccgc aagttttaac agcaatcatc ttgactcaaa tcctttgttt ttgacacaat
     8221 caagcgataa cgctgaccga aaatttctga taaatgctcc aagtctttct cctgacagaa
     8281 gaccttaaca ttgggaccag catccatggt aaagtagcag gcctctcctt tctcacgaag
     8341 ctggcgaaca aagtccatag cctcataaga ggcatccgtc agataagaaa aggctggact
     8401 agcagtcttt gtcgtagcat gcatagccag ggcatttttc tccgttaatt ctccaatctt
     8461 ggcaaaatca ttttccttga gataaatcag catatcctga tagtccttct cagactgacg
     8521 aacccagtcg tcaaaagtcg tcgaggtttc cacacaaagt ttcatcccgt cacggctaga
     8581 gattggtttt ttcttgtcct ctagcaccaa cataatcata gctagtttca agtctgtctc
     8641 tacagggtaa atttctccac tatccttatc ccaggctcct agtggtccat aaaaactccg
     8701 agaagaagag cctgaggcaa atttggcttc ctgtgccaac tgacttctat ccaatccaag
     8761 cttgaaataa gcattacaag ccttgaccag ggcggacaaa ccactagaac ttgaggacag
     8821 gcccgctgca gtaggcatat tgttttgagt atcgatacgg acaaagccct caccagctgg
     8881 acgataacgg tcaataatct tactcatctt agcatgctcg acctcatttt gtagctgacc
     8941 attgatgtaa aattcgtcag ctgttacatt ggctggtaaa ggcgacaagg tcgtctctgt
     9001 atacatattt tccaaagtta gagaaatact gctagtagca ggcaccatct ctttttcttt
     9061 tttctttccc caatatttga taatagcaat atttgcgtag gaacgtactg ttacaggctc
     9121 tctatccatg tctgaacagc tcctttctct tctaatcttt ctgctagttc ttgtgcgtgt
     9181 gtcaaattgg ttaccaaggc tatgatacaa cctcctagcc caccaccgct catcttggca
     9241 cccagagcac catggctaag agtcgtttca accaaaaagt ctgcctcagg gctactgact
     9301 ccaatttctt ttaaatgtaa atgcgcttga ctgaggattt gtcccagtcc ttcagcatct
     9361 ttttgtgaaa tcgcaacttc tgcttgctgg gttaattctc ccaaggcatg caaaaacggt
     9421 agggcatcct tgcccttatt ttgaaccact tggatggctt cacgagtatg accataaaca
     9481 cccgtatcgg caatcaccaa ataggcggat aaatccatct caagttctgt aaatcctacg
     9541 ttcttgataa agcgaatagg ttggtcactg agacaggtct tagcatccaa accactagga
     9601 ttcatatggg caatcatttc agctcgattg accaagattt ctagtacatc atgaggcaga
     9661 tcagcctgat agtagtcaaa taccgcacga atggccgcta tgctgatagc cgctgacgaa
     9721 cccatccccc gtttctcagg gatagccgag tcaatctcac aacgaatgca ggcttctgtg
     9781 atatccaaat actccagtga ggcataaacc gccatggaca aggtatcctc ctcataaagg
     9841 cgccaaggac tctctgcagg aactacctta caggtcacct ccacctccaa aagaggcagg
     9901 gaaatggcag gataaccgta aacgaccgca tgttccccta ttaaaattat cttactatgt
     9961 gcctgaccga caccaacttt ttttgtcatt ttttcctttt actagacgaa aaaacgtctt
    10021 atttttcata caagtattaa ttctttccta tctattttat tatattttca caaaaaaagc
    10081 gattgtttcc attcacaatc gcttctttca ttattgaacc cattcgccat tataattgac
    10141 aaaatagcca tctacggtcg tattcactgc caaggcacct gagctataag cgtagtacca
    10201 tctgccattg acctggaacc aacctgtcgt catagaacga cgaaagaaac tccataccgt
    10261 taagtaaaga ggaaagtcgt gagggatcat gcgccattga caacctgttt tagtgacgta
    10321 caaagtctca ttaacaagta ctcgtttcgg ccatttatag gtgcggtgtt tggagaaata
    10381 gggttcaatc ttagcccatt cttgatcgtt taaatcagta tcatatgctt tgcgtgtcat
    10441 aactctagtt taacattttt tgtgaataca agttctaaat aatcgaccac gaaaatttct
    10501 taagtggaaa acgccttatg aagtatgcta cgggaaactt atgcacttaa tttgacaatt
    10561 caagatgtaa aaatatatac tatagtagat tgaaactaga atagtacacc tctacttcta
    10621 aaacattttt agaaatcgat ttgactgtcc tgatcgattt gtcctgttat tatttcattt
    10681 tactataata tttgataagt tatcctaaaa gtgttattat gttgttgtgt tatagattga
    10741 ttgaatctaa ctaaaggatc ctattcaatt actagaacta tcacatactc aaggtcagct
    10801 cacagatgag caactatttt ggttacaatg tctactaaat ttaagtcaaa caaataattt
    10861 agtcaaaatt aaaaaaaata gaggaacata aatatgatta caaaacagaa tgtaatagtg
    10921 ttctacgatt tttactagat aaaactgtaa attctgaagg aaggatcact tcttcaacag
    10981 aatttggaaa tttcgtaagt aatttatcat tccaacacgg aatagctgga ctactgtttc
    11041 ctctaaataa attgtacccc ccagaactgg attctaaaat actctctatc atcaagaagg
    11101 cagtgacaat tagaacgaca cacacatatg aatatcaata ctcactgcta tttggtgatg
    11161 caggctatct atggttactc ctacatttat tttctatcag taaaaatcaa tactatctac
    11221 aattagcaaa cgtcaccgct aagaaattaa tagagaatta tgatactcta gaggaaatag
    11281 actttgcatt gggaaaatct ggtgtcctat tatcattaat aaaatactat caatttacca
    11341 atgacaatac tcttaaaact ttcatccaca atagtatatg gggaaattta tcattatttc
    11401 ctacaaagag atacagccaa agaaagcatt ttagactata gctttgctca tggatattgt
    11461 gaaattgcat atgctttatt tgcctattct aaagtcttag aaccttctat gttctataat
    11521 gatctccata cattccatgc tgaattaaaa aaattattag aaaaagttac ttctaatact
    11581 gaaaatttag gaaatttaca actttcttgg tgcgaaggaa tttccggaat aatcttatat
    11641 ctttgtatgt acgattgtga cggaaacaaa gatattatta gtaaatatca agaatttgtt
    11701 tttaaccatc atctaaaaat gatgacagga tattgccacg gaataactag cttactacaa
    11761 accactgtct acaatcaaaa caaattactg atgaaaaaat ccaacaggta attttagcat
    11821 gttctgaacg agatgatcac gatttactga tgtttcaagg agatagtggt aaaacagatt
    11881 tgtttgactt cggaatagga agcagggggt atattggtgt ctattaaata ataaattccc
    11941 attcgatgtg cagacataag gagaaaagta tgaaattatt ttggacaaac aacatatata
    12001 gacagttgct gctaaacagc tgtttttcat cattcggcga cagtattttc tacctcgcca
    12061 ttatcaatta tgtggctcag tacaatttcg ctccgctagc gattttactg atttccattt
    12121 cagagatggt tcccctacta tcgcaactct ttctcgggat tctaggagat tttcaagaaa
    12181 atagagtcaa acacgcactc tggattgcca aaatcaaaat cctgctctac gctattttga
    12241 cagtatttct cgtcttgtcg cccttttcat tagtttcagt cattatgatt gtcatcatca
    12301 acctcatctc tgacaccttg agctacctgt ctgcctacat gatgaacgcc ctctacatca
    12361 gtgtaattaa ggacgacctg catgatgcca tggggttcag gcagtctctg atgagggttg
    12421 tccacattgt cgccaatctg gctggcgcat tccttatcaa tgttatgagt attcaaacta
    12481 tttcccttat caacactctg acttttgtca ttgccttttt gggtctgtat gttattagac
    12541 ataccttgta tgaggttgaa aaaaggattg aaatgtcaca tacagcactg agttttaaga
    12601 aatattttca acatcttaaa cagtcgctgg ctgtgctcct gaggttaaaa gataccgtca
    12661 tactactgtt tctgacgacc agtatgattg ccatcttgga tgtgtcccct cggctgattg
    12721 ccctccgctt catccaacag acactagcac aactgagcat tgggcaactc ctcgccctgc
    12781 tctccatcat catgtcttgt ggagctatcc ttggcaatat gaccagcagt aatctattta
    12841 aaaatatccg tttcacgcac ctcttggttt tctgtgagat ttccctattg actctaataa
    12901 ctagtatcct ttgtcaagcc tatatcgtaa ttttcatgac cagtttcatc agttctacga
    12961 ttatcggcat tctcagccct cgcctacaag cagctgtctt tgcccatatc cccagtgaca
    13021 agatggggac ggtgggctct gctctgagca cagtggacat tctcgccccg tccctgctct
    13081 ccctattagc cctatccata gcatcgggcg tttcggtgca gttagcatcg atatttttgt
    13141 atcttatttt aattgctctt atcttttgtc aatggttagt caagttcaac actcataact
    13201 aacgaaaaag catgtgtaga tttcacatgc ttttaatctc cccaatagtc aggtcaagta
    13261 caacaaagtc acttctttga ttaagcgagt gttctaatat aattataagc gccctgtcat
    13321 taccgaaccc attcgccatt atagttgacg tagtagccat ctacggtcgt attcactgcc
    13381 aaagcacctg agctataagc atagtaccag ttgccattga cctggaacca acctgtcttc
    13441 atatctccat tacttgtatt taggtagtac caagttgaac catcttgata ccagccagtc
    13501 ttcatatcac catttttatt atctaagtaa taccatttgc ctcgtacata tttccaacct
    13561 gttgccatag aaccagagga gccaaaataa taccattttc cgtttacttt ttgccaatct
    13621 gtaagcatct tacctgaagc atctaggtag taccatggag caggtttgct tctatcaatg
    13681 tcaatagtaa catgaaaatc ttgagtccaa cccttagcaa cttcaccaat tggtagtgga
    13741 ttgtaagaat catcgccaaa atttcctagc ttatttaaat aataccaatg accctcttca
    13801 taaatccagc ctgtctttac agcataatta ttatcaaaat aataagttct cttttcagca
    13861 gatagaggat attgttcacc gtatactttt cctgtatttt cagacgtttt tgcctctagt
    13921 acttgtttat ctgtttgttc tagcaaagca ccatcttgtc caaaatagta ccacttctcc
    13981 tgaaggccaa tttcgaagac tggacgatta tcaaataaat catcacgata acctgttcca
    14041 ggaatttcta agtattgcca accgacaacc atctctccaa tatcaccaaa atagtaagtt
    14101 ttaccgtcta ttttatgcca atagattgct ttatgatcat cttttacata atattttcta
    14161 ttatccttat caacaaatcg gccacctgtg gtattcgcaa ataccgtatt tgtagctagc
    14221 aaaccaaaga aaaagactgc tagtagaact tgcatcattt ttttcaaaag tttcatttat
    14281 atatcctcct aaaacgattg tagcaaagac ccgactgcat gtcaatatat aaaaactcct
    14341 caaaaaagca gttacacaac tgcaactgct tttctattct tgcatggtgt aaccaacacc
    14401 acgcacggtt ttaatgtagc ttttttgtcc tttaacatca agcttgctcc gtagatagcg
    14461 gatatagaca tctacgatat ttgtctcggt cgcactttca tacttccaaa cactttccaa
    14521 caattgctca cgagtcaata ctttcttgct tcccataagt gtcgccaaaa ggtcatactc
    14581 acggcgggtc agagcaatca tctcttcacc acgataaacc gtgtgatgtt caacatctat
    14641 cctaagattg cggtaggtcc ttggaacttt catcagactg cagtgttgat caatgaagtc
    14701 ccgacctcgg aagatcgccg aaatacgcgc taccagattt tcgataagga ctggcttata
    14761 gatgtatgaa actgcaaaac gctgaacaac ttccagctct tcttgcaagt cttcccaatg
    14821 atctaaaatc atgatgactg aggcaggttt agttcggctc aatttttctg caaaatcctg
    14881 agccatcata tctcccagat taacgttcaa taaaatcaaa tcatagtctg tctgaagagc
    14941 catggagagg gctttttgcc cctcctctac cagatcaacc cgatactgct ctttctggag
    15001 ttccaaactt aaaaaatgag ctagatttcg ttctttctca agtaataaaa tccgtttccc
    15061 catggctgac ctacttattt ttcgtcatac caagagtagt ggaaggttcc ttctttgtct
    15121 ttacgttggt aagtgtgagc accaaagtag tcacgttgtg cttggatcaa gttagctgga
    15181 aggtcagctg aacggtagct atcaaagtaa gtaatagctg ctgagaaagt tggcactggc
    15241 acaccagctt gaaccgcaag agctacgata tcacgcactg cttgttgata cttagcagta
    15301 acatccaaga agtactcgtc caaaagaagg ttggcaagat ctgcatcgcg gttgtaagca
    15361 tctgtaatct tttgcaaaaa acgagaacgg atgatacagc catcacgcca gatagatgcg
    15421 atatatgcaa atggcaagtt ccagttgttt tctttagagg ctacacgcaa ttgagcaaat
    15481 ccttgtgcgt atgaaatgat ttttgagaag taaagggctt gacggatctt ttcaatcaat
    15541 tcagccttgt ctccttcaaa gttgaaggca gctggttttg gaagcacctt gctagcatat
    15601 acacgttctt ctttgtaagt tgaaatgtag cgtgcaaaca ctgactcagt aatcagtgac
    15661 aatggtacac caaggtcaag agatgattgg ctagtccatt taccagttcc cttgttacct
    15721 gcagcatcaa ggatgtagtc tacgattggt ccatcttggc cttcatcgtc tttacggctc
    15781 aagatatcag ctgtgatttc gatcaagtag ctatccaatt cacccttgtt ccactcagta
    15841 aagatttcag ccatatcctc tgcagaaaga cctagcaagt gttgcatcaa gtcataactt
    15901 tctgcgatca attgcatatc accgtactcg ataccgttgt gaaccatttt cacatagtga
    15961 ccagctccat caggaccgat ataagtcaca catggtttgc catcttctgg tgctttagct
    16021 gagatttctt caagaacatc cgcaaccaat tcgtaggcct ctttttgtcc accaggcatg
    16081 atagaaggac cttcaagagc acctttttca ccaccagaaa ctccagtacc gataaagttg
    16141 atacctgagt ttgccaattc ttcattacga cggatggtat ctttgtagaa agtatttcca
    16201 ccgtcaatca agatatcacc cttgtcaagg tgtggaagaa gggcttggat agtagcatct
    16261 gtaccaggtc cagcttgaac catcagcatg atacgacgag gtttttcgat tgagtttaca
    16321 aaactttcaa cgtcatagct tggtacaaaa ttcttttcag gatggcaagc aatcacatct
    16381 tccgtttttt ctttactacg gttgtagata gcaactgtgt aaccacgtga ttcaatatta
    16441 agggcaaggt tacgacccat tacggccata cctacgacac caaagttagc ttttgtcatt
    16501 tgacactcct cttgtttcat ttgttttatt ttatcatttt tacttttgaa aagaaagaat
    16561 tttgtaacga ctgcttagta gtccaagtca tccgcatgac cagcgccatt tccgacaaag
    16621 tagcctgtct tacagttaag ggtaaagaga taggttccat ctggcttata gaggttgtaa
    16681 taaccattgc cgttaacgat attgacacgt tcaaggatat attggtctcc agtgatatag
    16741 ccacgtgaac gtgaagtcgc tagaatttgt tccaagacac catccgcaaa atcccaggca
    16801 gagttattac tatcatcaat agcagactga ttataggcaa cacgactggc acttctttga
    16861 acagcaaccc ctgcactcga gagacccata ttgacttcac tgcgactact tctagtctca
    16921 tttgaactac ttggttttgg ctcactagtc gtatttgaac ttgcttgact tgaacttgag
    16981 ctgctagttt gacttaaact tgagctagaa gtacttgttt gctggctctt accaagactg
    17041 atagccttat ctagcacttt atcaagctcc gtatttccag ttttaatatc tgtaaattta
    17101 gcatccgatt tggctttggc attggtatcc aacacaccat ccacaatagc tgatttttca
    17161 aattgtgcat tgacatcttg aatagccttg atttgcgttg ctagactatc atatttagat
    17221 ttggcaagcg tatgttcacg actaccttcc agcttatcaa gtaaagtctt gagttgattc
    17281 agtttatcaa actggctatt tttcaaagcc gttttattgc tatctgtgta aaaggcgtca
    17341 taaagtgtat taaaatcatc cacatccgat tgattggctg tagttgattg agaagtttca
    17401 atttccttgg tcgaacgagc cacttgacgg tagacataat aagcactgac acaaataatt
    17461 actgatacaa gcgccaaaac ggtcaaaata aagccttttt tacttttctt ttctgagtcc
    17521 tcttgatcca gacgagaaag gttttgctcc tcttccactt cttcagtcat ttctgttgga
    17581 ttttcatcat ctagcaatag aggatccaag ccttgctcct catcgtccag aggcaagggt
    17641 agtaagatgt cttcagaaga tggaacttcc tccgaagaag cttctgactt ctctacagcc
    17701 tcacgcatct cttgaattaa atcatccaga ctctgagttt caacgaactc ctcttttttg
    17761 tattgacgag tcgcaaactt atccgcctca atttcatctc tgtgttgctt aacatacttg
    17821 tccaaaatgg aatcctcagg caagactcct gcttccactt cttcattttt acgaatagct
    17881 tgaccaactg ttagctcttt tgcttcatca aaatcaaatt gcggttcttg accttctttt
    17941 ttttgacgat ttcgtctttt tttactcatg agtatccttt ctattttacc tcttgccgtt
    18001 tgacacgctg accaaaatat tgatatagat ccactttcaa ggttccgttg tataacttac
    18061 gcttcttatc tgcttggcta ccatacttgc tttcaaaagc ttcatcacta gtcaggataa
    18121 atttgctcca agttttcagc ggtgcaaata cttgccccat ctcagcatag agcttggtca
    18181 cccctgcatc atctgacaaa cgttcaccat aaggcggatt ggaaatgatt actccattga
    18241 ttttatcgga acgtaaatcc tgcacgcgca tctgcttaaa agtaatgtct cctgcaacac
    18301 cagctacctg agcattggcc ttagcaattt ccaccatgcg agcatcaata tcacagccca
    18361 tgatatccag ctcaagctca cggtctactt ttttagccgc ttctgtgcgc acttcttgaa
    18421 tcaagcgatc gctgatccag ttccattcct caaatgcaaa agagcgacga agacctggcg
    18481 ccatctttct agcaatcata actgcctcaa tacagaaagt ccccgaacca caggtcggat
    18541 caatcaaagg cttgtctgga taccagttag aaagttgtaa aatggctgct gccatatttt
    18601 ccttgatagg agcgccacct ttttcggtac gataaccacg tttaaagagg ctagacccgg
    18661 tcgtatcaat catgacagtt gccacatctt tgagaataga gacctcaatc ttaaactctg
    18721 ggccattctc catcagagga accccttctg ggcgagcata gtgtttctgc aatttcttga
    18781 caacagcttt cttagaaata gcctgaacac tgggctcatt gtgaagtttg gacttaacac
    18841 atttagcttt tgaaatcggg aaccgagctc caagtggtaa ataattttcc caatccaaag
    18901 cgaaaactcc ctgaaatagc tcttcaaaag tcttagctgg gaacgttcct acgataattt
    18961 tgatacgatc tgctgcccga agccaaaggt tggtttcgat aatagctctc acgtctcctt
    19021 gaaaacgaac acgtccattt tcaacctgac aatcgtagcc caactctcgc acttcacgac
    19081 caacgacagc ctcaagccct gctgccacag ttgcaattaa attaaattct tttttcatgt
    19141 tacagtcttg caagaccttt ctatatgtcc actttaaaaa atgaggttga gaaaatttct
    19201 cagccccaac ctatatgcaa ttttctataa gccatgtttt gttccagaag tgactaggac
    19261 cacttccttc gataatcatc tgtctaccac taacagctct agctgatagc agtcagaata
    19321 ctacgttcgt ttccgcgtac tccatgcccc gaccaaaatt tgggttgcta gcttgagggg
    19381 tttaccgcgt tccactctct ctgtttccag aaagactccg tcactgtggc actttcaagc
    19441 ctactctggc ctatccaagg acttagccat ttcaactgcc gtaacgattt ctcgtcccta
    19501 ggcttatggt ttcgcctagc acaaacacta caggcatcac agcctgtgct agcatggact
    19561 ttcctcatga gaagcaattc tcctcacgcg attatccaaa aattgcacat ctcaaataac
    19621 tacttaaaaa tctgagttat ctaaaatttg tttaccaaaa acttcttttt ccaatctatt
    19681 caggcgtttc aaaatatcaa aattcgtcat agaacttgta attgccgctt caaggggttc
    19741 tgcttgaact ggtgaaggtt tcggtttacg agttaattct tccttcaaat ccgcaatttc
    19801 ctgacgaagt gacttgacca aggcagcata ggtttcatag tccttgatga catcgtctaa
    19861 aaactcgtca acttctactt tattatagcc acggacttca cgtccaaact cttgttcaaa
    19921 aatatctttc gctgaaaaaa taatacttgc catgtctctc tccattctcg cttgctagta
    19981 ttattatata aaaaaaggca aacaaaaatc aaggtcaaag cttcaatttt cggaaaaatt
    20041 ttcagcaagt tcatttaatt gatcaaatgt taatctcttt ataaaatagt cctcttgatt
    20101 tttcatcttt tggtaaaaat aagctagttt tgtttcattt tcttcatcat aaaaaagata
    20161 ggaactagtc gtgttttcca gcaaaaactg ctggtaatct cttaactgcc ccttgtgttc
    20221 atagcgagga taggcatatt tgacaaagtc tacctgctta aagcgactca gtttcatctg
    20281 attgccttca ttccaatttt ccccatgggt ttcaaaagca aaaatggtgg ccaactggaa
    20341 accgtattcg gttttcatct cctgagcaac ctctaaaacc caatattcaa aacccaaact
    20401 ccctgtaaac acaagccaag acaccccatc tgctgccata gcctctaaat ctttacgtat
    20461 cgctttttta atcaatttaa gacgaggatc cttatcagaa aataaaccca aatcaaaagc
    20521 agaatagcct aaaaccaaag ctgtagccat ttttaaccct ttctgtgcaa attatggtat
    20581 aataaagtga tgttattgta ccaataagga gaattatggt caactatcca cataaagttt
    20641 catcacaaaa aagacaaaca tctctttctc aacccaaaaa tttcgcaaat cgaggaatgt
    20701 cttttgaaaa gatgatcaat gctaccaacg actactattt gtctcagggc ttggctgtta
    20761 tacataagaa accaactcct attcaaatcg tacaagtgga ctatccacaa cgaagtcgtg
    20821 ccaagattgt tgaagcctat tttcgacaag cttcaacgac ggactattct ggcgtttata
    20881 atggatatta catcgacttt gaagtcaagg aaacaaaaca aaaacgtgcg attccgatga
    20941 aaaattttca tccacatcag attcagcata tggaacaagt ccttgcccaa caaggaatct
    21001 gctttgtcct tcttcacttt tcttctcagc aagaaaccta cttattgccg gcattcgatt
    21061 tgattcgctt ctatcatcaa gataagggac aaaaatcaat gccacttgaa tatattcgag
    21121 aatatggata tgaaatcaag gctggtgcct tccctcaaat tccttatctc aatgttatca
    21181 aagaacattt attaggtggt aaaacaagat gaacaaacca acgattctgc gcctaatcaa
    21241 gtatctgagc attagcttct taagcttggt tatcgcagcc attgtcttag gcggaggagt
    21301 ttttttctac tacgttagca aggctcctag cctatccgag agtaaactag ttgcaacaac
    21361 ttctagtaaa atctacgaca ataaaaatca actcattgct gacttgggtt ctgaacgccg
    21421 cgtcaatgcc caagctaatg atattcccac agatttggtt aaagcaatcg tttctatcga
    21481 agaccatcgc ttcttcgacc acagggggat tgataccatc cgtatcctgg gagctttctt
    21541 gcgcaatctg caaagcaatt ccctccaagg tggatcaact ctcactcaac agttgattaa
    21601 gttgacttac ttttcaactt cgacttccga ccagactatt tctcgtaagg ctcaggaagc
    21661 ttggttagcg attcagttag aacaaaaagc aaccaagcaa gaaatcttga cctactatat
    21721 aaataaggtc tacatgtcta atgggaacta tggaatgcag acagcagctc aaaactacta
    21781 tggtaaagac ctcaataatt taagtttacc tcagttagcc ttgctggctg gaatgcctca
    21841 ggcaccaaac caatatgacc cctattcaca tccagaagca gcccaagacc gccgaaactt
    21901 ggtcttatct gaaatgaaaa atcaaggcta catctctgct gaacagtatg agaaagcagt
    21961 caatacacca attactgatg gactacaaag tctcaaatca gcaagtaatt accctgctta
    22021 catggataat tacctcaagg aagtcatcaa tcaagttgaa gaagaaacag gctataacct
    22081 gctcacaact gggatggatg tctacacaaa tgtagaccaa gaagctcaaa aacatctgtg
    22141 ggatatttac aatacagacg aatacgttgc ctatccagac gatgaattgc aagtcgcttc
    22201 taccatcgtt gatgtttcta acggtaaagt cattgcccag ctaggagcac gccatcagtc
    22261 aagtaatgtt tccttcggaa ttaaccaagc agtagaaaca aaccgcgact ggggatcaac
    22321 tatgaaaccg atcacagact atgctcctgc cttggagtac ggtatctacg attcaactgc
    22381 tactatcgtt cacgatgagc cctataacta ccctgggaca aatacccctg tttataactg
    22441 ggataggggc tactttggca acatcacctt gcaatacgcc ctgcaacaat cgcgaaacgt
    22501 cccagccgtg gaaactctaa acaaggtcgg actcaaccgc gccaagactt tcctaaatgg
    22561 tctcggaatc gactacccaa gtattcacta ctcaaatgcc atttcaagta acacaaccga
    22621 atcagacaaa aaatatggag caagtagtga aaagatggct gctgcttacg ctgcctttgc
    22681 aaatggtgga acttactata aaccaatgta tatccataaa gtcgtcttta gtgatgggag
    22741 tgaaaaagag ttctctaatg tcggaactcg tgccatgaag gaaacgacag cctatatgat
    22801 gaccgacatg atgaaaacag tcttgactta tggaactgga cgaaatgcct atcttgcttg
    22861 gctccctcag gctggtaaaa caggaacctc taactataca gacgaggaaa ttgaaaacca
    22921 catcaagacc tctcaatttg tagcacctga tgaactattt gctggctata cgcgtaaata
    22981 ttcaatggct gtatggacag gctattctaa ccgtctgaca ccacttgtag gcaatggcct
    23041 tacggtcgct gccaaagttt accgctctat gatgacctat ctgtctgaag gaagcaatcc
    23101 agaggattgg aatataccag aggggctcta cagaaatgga gaattcgtat ttaaaaatgg
    23161 tgctcgttct acgtggaact cacctgctcc acaacaaccc ccatcaactg aaagttcaag
    23221 ctcatcatca gatagttcaa cttcacagtc tagctcaacc actccaagca caaataatag
    23281 tacgactacc aatcctaaca ataatacgca acaatcaaat acaacccctg atcaacaaaa
    23341 tcagaatcct caaccagcac aaccataaca tttatcaccc agatttttct gggtgatttt
    23401 gtcatagcac tattgtattt atgtgcttaa caaaagcctg agaagacatc ttctcaggct
    23461 ttttctgtac tataaacctc attggaaaag atagagactg cttccgtaat cttgttaaga
    23521 ggttttacta aatactagtc tttcttcgtt tttactacaa agagagcaga tagggctagg
    23581 ctaacacctg ctaggaagag ggctgtgtca gattgactct cacctgttgc tggcaagatt
    23641 tgttcaggtg tttctggtct agctatttct tgcttataat ctggcgtctt accttgctcg
    23701 gaagctaaag agctaagttt aaactcaggt ttctctacag ttggagcatc tggtttcgta
    23761 gcagaatctt ttaattggtt gagataatct gcaaagtatt ccaccattct ttccgtcaag
    23821 agatggttat ccgtcgcata tttcatgctt gcctgaacgc tagctacttc ctcttgattg
    23881 tctttgtctg ttaatttctg agccttagcc aaagctgctt catagcctga caagtcaaga
    23941 ggtgtttctg ctacctgtgg acgagtaaag ataagttccg ctgcagattg gtatttatcg
    24001 ccaccatctc cgtaagtctt agtacctgta aggacaattt tcttagcctt aattgtctta
    24061 ccaaaatcaa tgtcttttgg cttattgtta tctggccaat cagttgcagt aaaggtatgc
    24121 tccttgccag actcatctgt cacaacaagt ttcacatcac gcaagttacc atttgaaccc
    24181 gatccacgtg gaacgtaacg aagtccagtg atttcagttg gttctttcaa gaccatggtt
    24241 gcaggcttgc ctacatctcc accattccaa gatgtatgcc atagactaga cacattgcca
    24301 tcaaaagcat ttgcaagacc ttcttgagcc tgagcaggag ctgtaagact tgcaaaatca
    24361 tctgctacca aagccgtttt cttctgaacc aaagcattct tcaaggcttc aatcttggca
    24421 atctctgcac gcgcttcttc cacactgata tcatcatcgg cctgactgag gttaaagacc
    24481 gcctctttca aagcatccat agactctttg gtgtagttag tcatggcaac cgttggcaag
    24541 tagttcttca gagcattttc tgtcaacatc ttacctgtta gggtaatttc ttcgatttga
    24601 agattatcca tcatgaagtc gttataacca cggaagttgg catttccacc agaatcacca
    24661 cgagtattac ttgcattgcc agttgagtag atacctaccc aagtatcccc tgtttctgca
    24721 cctgtcacaa ggaaggttgc cttcttggct ttcttagaat ctgtccaagt atttggcaat
    24781 tcatgcattt ccaagttgct tgcttgagtg ccacgacgac ctgactggaa ttctccctta
    24841 ccgactacaa aagcataggt attgtctgaa cctgcttcgt attcaaaggt tacacggtag
    24901 gtcttacctg cttcaaaacg gaagttttgc ggaatagttt ggtaaaccaa gttacgacgg
    24961 ctcactagtc catttgtctt gagtgaccaa tttccttcga taacatcatc gactttctta
    25021 ccattccaac cacgttgtgt atatggatcg tgtttttcag acaagtgagt gcggttatct
    25081 tcaacacctt caacaccacc cactacaaat gggaagatac cctgagcaac attttcaaag
    25141 tcttgcttga aggtgccttt acctgtatca tgcttgtctc cgtacatgct tgaattgttt
    25201 tcaaaggtac gaatttcatc aaagtaagtt gcttgatcac cagcttcacg actcaatgtc
    25261 agagtaacat ttgagacgtc cgatccagtt gtaaagaagg cgtacatgtt ttggaagtaa
    25321 cttgtatcgt caactgtagc attgtcacga cgtgtattgt gggcgtaggc ttttacatag
    25381 ttgagggcga gagacttatt ggtataagta gtcacttctt tttcaccagt attcacagtg
    25441 atacttgcct tggcattact acggttatcg acaccgacat aaacggcata cttggtattt
    25501 ggtttcaagc cagttaattt ctgagtgaga ctaacttttt ctttgtttcc ttgaatacga
    25561 agcatatcgt ttgccccttg agacttgaca atttctgcct tagaagcatc gcctgaaatg
    25621 gtccaatgtt tcaaggtacc gctattaaat ccttggtcat agatgtgcat gccttcactc
    25681 catgacattt caggattggt ttgtttcgaa cgatagagaa cgtatggttg atttgctaga
    25741 agatctaggg taattttacc atcttttaca gttagttcct gctcttctgt cttaccttgg
    25801 tcagttagct tgtaaaggta aaccttgctc tttgcccaat cgcttggaag ggtccaagtt
    25861 gttgcaccag tctgcgtatt gaagtagtac atcttttcct tatcagtagg aagtttctta
    25921 ccattcgcat cccagttcca aggagtcaag taagctgaac catcttggat gacacgtccg
    25981 ttgagagtta ctgtacgttc gcgatattgt gggctattga catcatttga cttacgagtt
    26041 acaactactt tattattgtc agcatctacc aattccactc gcatttctgg agtccattta
    26101 taggtgctac cgttatcggt catagtcacc ggtgtaccat tttcccattt acttacagtg
    26161 aagtgttgga agtacttagt catgacgtca tgggcaaata agttggttac atagccattg
    26221 tagtcacttc ttccttgcca gccttcaaag tctttcatgc tgtagccacc tagcagtgga
    26281 tagttggctg caccaccata acttctgtag tcccctaccc aagcatcttt ttggtggtta
    26341 cggataaagc gggtgatggc actgttgata cctttattgg tgtagccacc gtaggtcaag
    26401 tcagctgccc agtgatggaa ggtagagtcg tactcaccac catggcccca ctcgatcgca
    26461 aagcgccagc cttgtttgtt aatttcttta gcaagaacgt gggtagccca ggcaccgtta
    26521 tcacctgatt gaccattacc ccaaacgtcc acatagataa agtcgagacc gtcaccaagt
    26581 tttttcttca aatcttccca acgtgccaaa cgaccatgag ctaggtcata ggcagcatca
    26641 atgttgatac cttgatctag ccagttccaa ccatagctat aacttccatc tggattctta
    26701 cggagaattt tttcattgaa gtatttagac tcaggataag tttctgaagc gttaacgtgg
    26761 atacctagat gagctccata tttcttagcc ttctcaatta gggtcttgaa gtcttcgaca
    26821 ccaccgatac gcttaccaat atcagcatag ttcaagtgac cagagtcgtg accttcacta
    26881 ccatatcctt taaggagaac accttgccca agaccatctg tgtggagatt gattttcttg
    26941 ataccatcca aggtcataag gaatgggttt tgtgcttgag aaccaaagtt catcgcgata
    27001 cggtaagctg tgatatcctt aactttttcc caaccttgag ggttgttcat aatgctacga
    27061 taagcaatgg caccatcttg ccaatcgact ttcttgtctg cattggcatc ttcagtgata
    27121 acaaccttag cacttggaag ttccttcgtg tattctggga aaacaatgcc cttataagct
    27181 ttttcccatt gccattcaga gctgtggatt cctacatagt tggcatttcc gactgtttct
    27241 ttataagctg tcaaacgagt ccagtcattc gaaccaccac catagctatt ttgagagtta
    27301 ctccaaacac cagcagcaag cttatctgta gaaacaaatc catacatgta acccttagcc
    27361 aaatccttca ttggattggt tacatcgata tgatcatctc cgctgacatg cgtattgttt
    27421 gacatggttg ccccatcaaa cttagcacca gtttgatcac tagaaacaga gactaaagca
    27481 ttgccgagga aactaataga agaaagtagt tttctttcgt catcaatctt ttgacctgga
    27541 gtgacttgat tgtggttgac aatcttggtc acatcaaagt gcaattgatt gtccacaact
    27601 tgcaagcgta ctgtcatttc cgcattgatt aagtgagcat catcgcgaat cttcatcaag
    27661 tactctgctg ttgtctcatt gattttctta taagtgactt caggggtgat tcggtggtta
    27721 ttgataaaga cttggttgaa ctgttgcacc tgtcctggca aagtatgtcc attcaaggtg
    27781 tattccttga cacgagggaa ggcttggtca attactgcct taagtacctt agactggatc
    27841 gtatcataag tcaccttgct atcgtcaaca accggacctg tttctttctg ggcaggagta
    27901 tcatccgctt ttacgccttc ttgattgtct gttttaacgc tgacaaccgt acggtcattg
    27961 ccataagagc ccgccttgag aagaatcttc ttctcatttt taagatggtc attgaccgca
    28021 gctggtagag tcactgtgtc aaagagattg acatcgttat tgctggcatt tagctgaccg
    28081 tctgacttga gagtgataga gagacggttt gttgatcctg tttcaggagc aacaacacga
    28141 ctacctctat accaagtgct agttgttgga gatttatact cccagaacca gccatccttg
    28201 tcataaccga caaaaacatt attattggta tctttaaatt tcaggaagac accaaagcgt
    28261 gatttgccct tttcagaatc atctttgaag gttaaatcaa cagttgcatt tccattggca
    28321 tcaacggtca agcccttctt ttcaaacagg gctggtttac ctgcgttatc attttgagca
    28381 gttgaggata gttggttgta gcggacacct ttttcttctc ggatagtgac tgttcccttt
    28441 tgttcttttt tctctaccgt ttgccattca ggggttaccg tcttaggtgt ttcaggttta
    28501 gcagctgcag gtttatcctc ttttggtttt tcttcagccg gtttttcttt ttcaagtgct
    28561 aatagttctt cttctgtctt aggtccatct gtaacttctg gagaaccttg gtcttcttcc
    28621 accttaggcg cttcaaaatc acgcccatca ttctcttttg ctgttgcaag agcagtagct
    28681 aaatcagctg gtaagttcgc cgtggaacca gactgcacgc tatctgcaag aaccggactt
    28741 gtcccaaaga atgcagctcc aatcataaca gaagcaacac ctaatgaaaa tttccgaata
    28801 ctatatttac aacgtttttc aaataatcct ttattcataa acttctaaat cctttcattt
    28861 ttgggcaaac gtttacattt cctttttaaa aaatactcct tcctctgaaa gtgcaatgct
    28921 taaccctgat aaataaaaaa taattatact tttaatata
//
LOCUS       DAVHSO010000025        28931 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.025, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000025 DAVHSO010000000
VERSION     DAVHSO010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 28931)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 28931)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..28931
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.025"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..244)
                     /locus_tag="VVR18_001075"
     CDS             complement(<1..244)
                     /locus_tag="VVR18_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6032617.1"
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKE
                     RISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTD"
     gene            complement(410..556)
                     /gene="pheS"
                     /locus_tag="VVR18_001076"
                     /pseudo
     CDS             complement(410..556)
                     /gene="pheS"
                     /locus_tag="VVR18_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646750.1"
                     /note="catalyzes a two-step reaction, first charging a
                     phenylalanine molecule by linking its carboxyl group to
                     the alpha-phosphate of ATP, followed by transfer of the
                     aminoacyl-adenylate to its tRNA; forms a heterotetramer of
                     alpha(2)beta(2); binds two magnesium ions per tetramer;
                     type 1 subfamily; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
     gene            complement(850..2574)
                     /locus_tag="VVR18_001077"
     CDS             complement(850..2574)
                     /locus_tag="VVR18_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 3 protein"
                     /protein_id="HEU6032618.1"
                     /translation="MPRLVDLRKKPYYLNDDQIVWVESTLENLTDEEKIGQLFVNLFF
                     FGGDAFSGNNLSNQELINRYHIGGARYMNGSPEQVQGLINDLQSYSKVPLLVAANCDS
                     GGDGAVKGGTYISSGAQSEASRDSRIPYLAGLVSAREETALGVNVNFDPCVDIVQNWR
                     NTIVNTRAYGTNADDVIAYTSAYLEGLTAERDVIQCIKHFPGDGTEERDQHLVLGVNE
                     LSPEEWDDSFGRVYHHHIEAGVEMVMAGHIALLYYQQKLNPSLKDEDILPATLAPELI
                     QDLLKEKLEFNGLVITDASHMLGMTAAMRREDYVPAAIAAGCDMFLFFNNLEEDFEFM
                     LNGYRNGVITKERLHDALRRILGLKAKLNLHVKQAEGTLLKSADELAIIGCEEHLAWQ
                     REAADKAITLLKDTQHNLPISPETHRRIRLYYLEGEKEGIMAASTEVVDNLKSALEAR
                     GYEVTVNDGTTRIKGKTLQYREEVDLALTVANVIGYGAQNNYRIQWKTAMSNEVPWYV
                     HEVSTIFVSLNYTTHLHDVTMVKTAINAYHHNKNTIESLLDKLEGKDEFYGIPNENVW
                     ANKWQAKL"
     gene            complement(2585..4375)
                     /locus_tag="VVR18_001078"
     CDS             complement(2585..4375)
                     /locus_tag="VVR18_001078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-hexosaminidase"
                     /protein_id="HEU6032619.1"
                     /translation="MTHLVDLRKKPYNLDEEAISWVENTIAQMTLDEKIGHLFVNMGI
                     QRTEKYLTGVLEDYKIAAVRYNPGPAADIWEQNYILQTKSKIPLLIAANTESGGNGAV
                     TDGTKIGDEIKIAATADSRHAYEMGKVAGIEAAAVGCNASFAPIMDLSRNWRNPIIAN
                     RTWGADVDQVIELSKEYMRGIMEHGIVPFAKHFPGDGIDERDHHLSFASNPMTKSEWM
                     ETFGRIYGEMADAGLPGIMAGHIHLPNVEKEMHPERELDDMLPASLNKTLLDELLRGE
                     LGYNGAIVTDASHMIGMTASMPRRELLPTAIEAGCDLFLFFNDPEEDLQWMKEGLKNG
                     LLTEERLHDALRRTLGLKAKLGLHLFEGRRQEIMLPKEEALALIGKDEAKNLAKEVAD
                     KAITLVKSKQEGIFPVNPDRYKRILLVEVDGYKGGFGAMINAGKKRAADTLKELLEAR
                     GHEVSIWENTEARIAKLPEEERPAAIANVYASKRPIAEITDNYDLIINLVDVNSGGTT
                     QRIIWPAAKGTPDQPFYVHEIPTIVVSVQHPFALADMPQVATYINAYDGLPVTLETLV
                     TKLAGESSFTGVSPVDAYCGLVDTHIWRGN"
     gene            complement(4422..5219)
                     /locus_tag="VVR18_001079"
     CDS             complement(4422..5219)
                     /locus_tag="VVR18_001079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014637816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEU6032620.1"
                     /translation="MKTDYVFCVDSDGCAMDTMTYKHKLFFGPLAADVFGVQDREAFL
                     TEWNRVNLYSRTRGINRFVGLVKGLEFAGVTGIEQLKNWVATTDSLSNASLEKLIAEQ
                     PSKDLELALEWSKQVNQAIKNYTGPVLAFIGVHKGLEKLSQLGKVYVVSSANKEAVDE
                     EWSEQGLLDFVTELYCQDRGKKEDVIKLLIDKGYNPDNIIMIGDSPGDLKAAELNNVH
                     FYPILVGREMRSWADLTETIADDFVNQTFAGEKETNLIQAFWKNLDD"
     gene            complement(5222..6061)
                     /locus_tag="VVR18_001080"
     CDS             complement(5222..6061)
                     /locus_tag="VVR18_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000047575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HEU6032621.1"
                     /translation="MTRVIEFKDKVVVITGAGGVLCGYLAKEFAKAGAKVALLDLNEV
                     AAQVFVDEIESVGGVAKTYKSNVLSKENLEEVRQQVLADFGPVDILVNGAGGNNPKAT
                     TDNEFHEIGLPVDTKTFFDLDEAGINFVFNLNYLGTLLPTQVFAQDMIGRSGANIINI
                     SSMNAFTPLTKIPAYSGAKAAISNFTQWLAVHFSKVGIRCNAIAPGFFLTNQNRGLLF
                     DESGQPTARANKILTNTPMGRFGEAEELVGGVFFLADENLASFVNGVVLPIDGGFSAY
                     SGV"
     gene            complement(6064..7164)
                     /locus_tag="VVR18_001081"
     CDS             complement(6064..7164)
                     /locus_tag="VVR18_001081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannonate dehydratase"
                     /protein_id="HEU6032622.1"
                     /translation="MKMSFRWYGKKDPVTLEEIKAIPGMQGIVTAVYDVPVGQAWPLE
                     NILELKQMVEEAGLEITVIESIPVHEDIKQGKPNRDELIENYKTSIRNVGAAGIPVVC
                     YNFMPVFDWTRSDLHHPLPDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKN
                     VIENYRQNISEEDLWANLEYFIKAIMPTAEEAGVKMAIHPDDPPYGIFGLPRIITGQE
                     AVERFLNLYDSEHNGITMCVGSYASDPKNDVLAMTEYALKRNRINFMHTRNVTAGAWG
                     FQETAHLSQSGDIDMNGVVKLLVDYDWQGALRPDHGRRIWGDQTKTPGYGLYDRALGA
                     TYFNGLYEANMRAAGKTPDFGIKVKTVGNKEG"
     gene            complement(7178..8578)
                     /gene="uxaC"
                     /locus_tag="VVR18_001082"
     CDS             complement(7178..8578)
                     /gene="uxaC"
                     /locus_tag="VVR18_001082"
                     /EC_number="5.3.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucuronate isomerase"
                     /protein_id="HEU6032623.1"
                     /translation="MSFNDKNFMLKNEPAKELYVKIAELPIYDFHCHLDPKEIFEDKV
                     YEDIVDLWLGGDHYKWRLMRANGISEEEITGFASKLDKFKAWARTLERAFGNPLYHWS
                     HLELRQVFGIEELLTEENAERLYHQLNTYLQEHQISPRKLIADARVAFIGTTDHPLDN
                     LEWHKRLAEDSPIDTVVAPTFRPDEAFIEHRNFNLFIKRLEEVTEVAVRDFASFVEAL
                     GQRVSYFAQHGCRASDISFTAITYEEATLEELNDILLARMVGKEVGQSGINKWQTAIF
                     RELCRMYKKHGFVTQVHFGALRNNHTGLFEKLGADVGVDSIGDQTCLTGNLNRLLDNL
                     VKENALPKMIWYNLNPGYNIALANTLANFQANEEGRRSQLQFGAGWWFNDTKLGMIDQ
                     MNAYAEQGMLANFVGMLTDSRSFLSYQRHDYFRRILATYVGQWIVDEEVPEDYDRLGQ
                     FVEAISYYNAKEFFEQ"
     gene            complement(8580..9200)
                     /gene="eda"
                     /locus_tag="VVR18_001083"
     CDS             complement(8580..9200)
                     /gene="eda"
                     /locus_tag="VVR18_001083"
                     /EC_number="4.1.2.14"
                     /EC_number="4.1.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002938042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="HEU6032624.1"
                     /translation="MLRQLKENYFFAVIRGKDEQDAKEIARHAVLGGIRNIEITFSTP
                     NAATVIKELQEEFSDDSSVVIGAGTVMNLNLAQEAIGAGASFLVSPHFDKKIQELAQE
                     TGVLYFPGCATATEIVTASQAGCSIIKLFPGGVLGHGFIKDIHGPVPEVDLMPSGGVS
                     VDNVADWKKAGACAVGIGSALASRVQAEGYDSVTLIARSFVAALEG"
     gene            complement(9323..10039)
                     /locus_tag="VVR18_001084"
     CDS             complement(9323..10039)
                     /locus_tag="VVR18_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HEU6032625.1"
                     /translation="MAKPLVEKASERLLELILERGYEVGDKLPNEYELAQDLEVGRST
                     VREAVRSLATRNILEVRQGSGTYISSKKGVSEDPLGFSLVRDRVKLTTDLFEVRYLLE
                     PRIAERVAQFASDEDVAKLEEIVLAIEEAVAAGDTKHLELDVKFHCMLAEMSGNLAMT
                     SLMPVINQSIHLINENYSNRQMKSNSLQAHRNILMAIKQRHPVAAYDSMLAHIISVRQ
                     VVLSEWFDKDMTLHGLNDHK"
     gene            complement(10085..11884)
                     /gene="uidA"
                     /locus_tag="VVR18_001085"
     CDS             complement(10085..11884)
                     /gene="uidA"
                     /locus_tag="VVR18_001085"
                     /EC_number="3.2.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-glucuronidase"
                     /protein_id="HEU6032626.1"
                     /translation="MLYPIQTKTRSVYSLNGIWAFKQGNNDVQSLLDTDEVMVVPSSF
                     NDIVVDKEKRRFVGDNWYELMVAIPAVSDDEELVVRFGSVTHQAMVYADGQLIGKHKG
                     GFTPFECLVPSELYGLDQFRLTVCANNELNYTTLPVGNYSEEVDENGQIVKTVKENFD
                     FFNYAGIQRNVHLYKRPKNRVDDIVIRTELNNELTQAVVHVEVATVGQYDSIRIHIFN
                     QEGQELGLLENGRIVIDNPRLWEVLDAYLYTAKVELFDGESLLDTYCEQFGLRSVAVE
                     NGQFFINGKPFYFKGFGKHEDTFINGRGFNEAANLMDLNLLKDIGANSFRTSHYPYSE
                     EMMRLADRLGIVVIDEVPAVGLFQLFNAALNLTGDSDEVKNTWEVMQTKDAHELVIDE
                     LIARDKNHPSVVMWVVANEPAGHEKGARAYFEPLIQRMRDRDPSNRPVTLVNIMTATP
                     DKDEVMDLVDVVCLNRYYGWYAAHGDLKMAEKGLRKELETWQELYPDKPILITEYGAD
                     TLPGLHSMWDIPYTEEFQVDYYDMNHRVFDSISNVVGEQVWNFADFETTVGLIRIQGN
                     HKGLFSRNRQPKQIVREIKKRWTAIPNYHYKRK"
     gene            complement(11899..12927)
                     /locus_tag="VVR18_001086"
     CDS             complement(11899..12927)
                     /locus_tag="VVR18_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002939788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HEU6032627.1"
                     /translation="MKKILAFGEVLLRLSPPHYQTLTQARSLECQFGGSELNVLASLA
                     QLGHSVELVTALPRNEVGKMAEHFLFARQIGQKYLIRKEGRLGLYYYQKGFSLRPSQV
                     TYDRDYSAFSLSREEDYDLEGIFEDVDWFHVSGITVALNPVIRQLAFRLMEMAKEQGI
                     KVSFDLNYRESLWSSFEEAREKLSPFVGLADICFGLEPIQLLNESGKDMKDELGLKRS
                     YENREILLSVVKALAETYSLQSIAFTQREMTYNNEYLLKAYLYQDGVLYETEKESIQV
                     LDRVGTGDAFTAGIILGYLQEKSPQEVVDLGMASFQFKHTIEGDVNVISQSDIDLLLK
                     KGSREIKR"
     gene            complement(13003..14556)
                     /locus_tag="VVR18_001087"
     CDS             complement(13003..14556)
                     /locus_tag="VVR18_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6032628.1"
                     /translation="MEKHVEQRVEDVTYNKAKLWQIILFAMNNSSTNIYLVAFTFVTY
                     LSTGVLGLAALFVSQLMGYIRIFDGFIDPTIGVIIDKTDTKFGKYRPILVLGNIITAS
                     SLFMMLGLSGVSENLRLPLFILVLIIHKIGYSLQQTITKAGQVALTNDPKQRPIFNIV
                     DGIATTVLMTGSQVVVSGTLVPKHGGFTPSFFQELFLGVVIISAILGILAIIGIWEKD
                     NKKYFGLGEKTQETKLKDYWKVIKGNKPLQVLSISAAFVKFVAQLFGDSVIGVMLYGI
                     IFGDYALSGKMSMLLILPGILVTVGAAQLARRKGLRFAYITALQLGIAGLVALAAMLF
                     SAKPGMLDLTNWNLYTIGFFVVYIIARYASGAPSGLVLTMGADITDYETSVSGRYLSG
                     MIGTIFSLTDSIASSFAPMVVGFVLAGIGFGKEYPTVETAFSTDLRMALIVLLTVIPA
                     AVLSVSLFLMKFYKLDREEMARIQEKIHVMKAAKDEERVRAIAKNVPLSDMDYVDVTQ
                     YKVEQYEDK"
     gene            complement(14743..15027)
                     /locus_tag="VVR18_001088"
                     /pseudo
     CDS             complement(14743..15027)
                     /locus_tag="VVR18_001088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014735752.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-entry nuclease"
     gene            complement(15133..15678)
                     /locus_tag="VVR18_001089"
                     /pseudo
     CDS             complement(15133..15678)
                     /locus_tag="VVR18_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014735752.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA/RNA non-specific endonuclease"
     gene            complement(15708..15899)
                     /locus_tag="VVR18_001090"
     CDS             complement(15708..15899)
                     /locus_tag="VVR18_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEU6032629.1"
                     /translation="MDKENLSYVGKNLLLVVIVLLIAALVFVLGLVLGYGVIGDGDNV
                     FAVLSPAKWQELIGKFTGK"
     gene            complement(15942..17171)
                     /locus_tag="VVR18_001091"
     CDS             complement(15942..17171)
                     /locus_tag="VVR18_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter"
                     /protein_id="HEU6032630.1"
                     /translation="MKLLFRNPAYRILTLSRFFNAFGASIFNLVFIVYASTLSQASFA
                     VAMANIVMILPTLFTVFVGIRADYTRDKVKWMVYSGLFQAVLFFLAALVVQQASLFAF
                     SSLCLINVISDIISDFAGGLRMPLIKEKVAENDLMEAYSFSQFITYISAIGGQAFGVW
                     LLGLSVNNFSLVAGINACFFLVSAVILFLGKSKLSLSMSSADGEKLKNEKLSIKDQFL
                     TIYRNLRLVFLKSGQKNFGFMLFAVLLINSLGGALGGIYNIFFLSHSLLNFSYTEALF
                     INQFCVLVAVIISSLTGNDYFGKQSLPRLMMWETVGLSLVGLANLFNQVVLGLLFLFF
                     TLYVSGKVQPKISAMLMKNLAPEVLARTSNFFGLLFTLSIPVGTACFSLVAVWNMQLT
                     WMLFVGFSLLAIFFDNS"
     gene            complement(17362..18213)
                     /gene="rgg"
                     /locus_tag="VVR18_001092"
     CDS             complement(17362..18213)
                     /gene="rgg"
                     /locus_tag="VVR18_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434947.1"
                     /note="Rgg, as the term is used in Streptococcus
                     pneumoniae, is the lone quorum-sensing system
                     transcriptional regulator related to proteins Rgg1, Rgg2,
                     Rgg3, and Rgg4 of Streptococcus pyogenes; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg"
                     /protein_id="HEU6032631.1"
                     /translation="MEQIGKVFRQLRESRNISLRQATGGQFSPSMLSRFETGQSELSV
                     EKFLFALENISASVEEILFLARGFQYDTDSELRKEITDVLEPKNIAPLEDLYRREYQK
                     HAHSHNKQKHILNAIIIKSYMKSIDERVELTAEEGKVLHDYLFSTEIWGIYELNLFSV
                     SFPFLSVSLFTRYVREMVHKSDFLMEMSGNRNLFHTILLNGFLASIECEEFTNAYYFK
                     RVIEEHFYKGNETYFRIVYLWAEGLLDSKQGRVKEGQKKMEDAVRIFEMLGCNKSAEY
                     YRNTTEC"
     gene            18337..18678
                     /locus_tag="VVR18_001093"
     CDS             18337..18678
                     /locus_tag="VVR18_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003080443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEU6032632.1"
                     /translation="MRDDIKINDRALALQDQIIEKLEKVFDTDVELDVYNLGLIYEIN
                     LDETGLCKIVMTFTDTACDCAESLPIEIVAGLKQIEGIKDIKVEVTWSPAWKITRISR
                     YGRIALGLPPR"
     gene            18736..18816
                     /locus_tag="VVR18_001094"
                     /pseudo
     CDS             18736..18816
                     /locus_tag="VVR18_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(18977..20680)
                     /gene="ilvD"
                     /locus_tag="VVR18_001095"
     CDS             complement(18977..20680)
                     /gene="ilvD"
                     /locus_tag="VVR18_001095"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HEU6032633.1"
                     /translation="MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVIS
                     TWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDI
                     IADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
                     IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLP
                     GSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNA
                     TLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLL
                     ANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDG
                     AVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEML
                     SLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQ
                     DTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGK
                     K"
     gene            complement(20913..21845)
                     /locus_tag="VVR18_001096"
     CDS             complement(20913..21845)
                     /locus_tag="VVR18_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HEU6032634.1"
                     /translation="MMRSTKELRHVYRDFLLEANQSDSDIVVLEADLSSSMATHNLEK
                     DFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFGPFASRRVFDQLFISLGYAQLDA
                     TVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
                     YIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSV
                     GVIDLFRIKPIPEQIKTMLSGKTIFTVENHNQIGGIGSALCELFSDDGITKIHRMGVQ
                     ERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR"
     gene            complement(21842..22699)
                     /locus_tag="VVR18_001097"
     CDS             complement(21842..22699)
                     /locus_tag="VVR18_001097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEU6032635.1"
                     /translation="MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVL
                     AVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNKNGTK
                     LPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
                     EAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIR
                     EIYEGIVQLKQSNNSSPKCIVLDTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVER
                     LSQELEETE"
     gene            complement(22703..24049)
                     /locus_tag="VVR18_001098"
     CDS             complement(22703..24049)
                     /locus_tag="VVR18_001098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000975284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEU6032636.1"
                     /translation="MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVG
                     FLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATALIMFAGM
                     VFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSIS
                     PAFVQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRD
                     STVSITLSMAVIYIIVAIFAGSEYIEKEISSGTSGLVYALQLAGQFAAGVFVILAGVR
                     LILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFVGGLVSMAIMIA
                     SGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGL
                     GFQGSTFSDADFGLSGIILGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSAKEE"
     gene            complement(24062..24346)
                     /locus_tag="VVR18_001099"
     CDS             complement(24062..24346)
                     /locus_tag="VVR18_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008089859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU6032637.1"
                     /translation="MLKIGTACGSGLGSSFMVQMNIESVLSDLNVSDVEVEHYDLGGA
                     DPNAADIWIVGRDLADSASHLGDVRILNSIIDMDELRELITKLCEEKGLI"
     gene            complement(24350..26380)
                     /locus_tag="VVR18_001100"
     CDS             complement(24350..26380)
                     /locus_tag="VVR18_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000460919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEU6032638.1"
                     /translation="MFDYRALVILMTLMDHCEVSLYELSVKVSLPIKEVKEGIDYLVP
                     YLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFIS
                     NNHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMV
                     SELLESSIGIWGLDYVLSSWGYSLTYDLIDQVVKDYYEKLQLVPIVNQLKVYLFGLVF
                     ILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSS
                     CFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLP
                     SSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLP
                     QKCYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIK
                     VETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELE
                     LRLALKNYLYQKNDRKEIVPVLEQLITKETYQVSSQKLGWKEAIRLAAKPLLDQDKIT
                     ENYPEAMIQKVEEFGPFINLGKGVAIPHARPDEGVNEIGMSMLVLEEPIYLLDNPEQE
                     VRLLICIAAIDNESHLKALSHLTTILRDKNHVQTLISSKNYDDIKMIIKQED"
     gene            26572..27579
                     /locus_tag="VVR18_001101"
     CDS             26572..27579
                     /locus_tag="VVR18_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEU6032639.1"
                     /translation="MTEKLINSKPNGVFALILIELTLVLGIFIFIMGVGSENIFGIII
                     GPLLIVIAGLAHAGLKVVKPQEALVLTLFGNYTGTIKEPGFYFVNPFSVAVNPANHTR
                     LGQSGDVSTKSPFLGAKSSNDNDVNLEIGKKHISLKVMTLSNSRQKINDCLGNPVEIG
                     IAVTWRVVDTAKAVFNVDNYKEYLSLQCDSALRNIVRIYPYDVSPNVDTTGDGQADEG
                     SLRGSSEIVANRIREEIQSRVEDAGLEILEARITYLAYAPEIAAVMLQRQQASAIIDA
                     RKMIVDGAVGMVEMALERLNEGELVELDEERKAAMVSNLLVVLCGNHDAQPIVNTGSL
                     Y"
     gene            27582..27782
                     /locus_tag="VVR18_001102"
     CDS             27582..27782
                     /locus_tag="VVR18_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEU6032640.1"
                     /translation="MAEAKKKQIPLRLSTKLYAALASWAEDDFRSVNGQIEYLLTECV
                     KQRKKDGKYVSETIDEPFEIDI"
     gene            27934..28116
                     /gene="rpmF"
                     /locus_tag="VVR18_001103"
     CDS             27934..28116
                     /gene="rpmF"
                     /locus_tag="VVR18_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HEU6032641.1"
                     /translation="MAVPARRTSKAKKNKRRTHYKVTAPSVNFDETTGDYSRSHRVSL
                     KGYYKGRKIAKAASAE"
     gene            28132..28281
                     /gene="rpmG"
                     /locus_tag="VVR18_001104"
     CDS             28132..28281
                     /gene="rpmG"
                     /locus_tag="VVR18_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001265622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEU6032642.1"
                     /translation="MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVV
                     FTEVK"
     gene            complement(28761..>28931)
                     /locus_tag="VVR18_001105"
     CDS             complement(28761..>28931)
                     /locus_tag="VVR18_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000753868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032643.1"
                     /translation="VKDKGLWYYLNESGSMATGWFTVSGKWYYTYNSGDLLVNTTTPD
                     GYRVNANGEWVG"
BASE COUNT         8957 a         6491 c         4954 g         8529 t
ORIGIN      
        1 agtccgttcc atagcctgtt aacagttgaa agaggaactg gacaaggata tctgaatccg
       61 aataacgaca gtagcggcgt tggtcattcg ttactaaata cttagaaatc cgctctttta
      121 gtttcaactg ggaaaaaagt tcctgaaaaa agataagacc accatactgg gttaaatgac
      181 ctccatcgaa agatagttgg taaaaagact tgttttggaa gtgatgattt ggtaaactgt
      241 tcatgtgagt ttcctttctt tttgtgtttt tttctacact tattccataa aggggaaact
      301 cttttttgtc tagtaaaaaa cacccattgg gtgaaaaaag aaaccatcca ggatctaagc
      361 taaggcaagg attctggatg gtttttagat ttggggtgaa taattggggt tttaataagt
      421 ctgtcaacga gccttttttc cccaagacag agacacgtag gtcttgcaat tctttctcac
      481 cttcatggtg aatttctttt agtctatcaa gcgtgctttg acgcaactca gccaactgtt
      541 gttcaatgtt tgacataatt cctccaataa aaaaaacgca tgacaccatt cgtatcggag
      601 cgttgtcacg cggcaccatc cgttttcatc tgctaggcag acctttattc taagtcctta
      661 tatgagtgaa ttcgaccaac tttcactgat tgagctttca gtcacggctc aactccctgg
      721 acagtttcca taggtgtact agtctcacaa acttctattc aattaagaat attctatcaa
      781 aatgcaggtc atttggcaag aaatcttgct aaaaaactcc ttctatctac gatagaaagg
      841 agcttacatt tatagtttcg cttgccactt attggcccaa acattttcat ttggaatacc
      901 atagaactca tctttacctt ccaatttatc aaggagggat tcaatggtat ttttgttgtg
      961 gtgataggcg ttgatagctg ttttcaccat ggtaacatcg tgaagatggg tagtgtaatt
     1021 gagagaaaca aagatggttg atacttcatg aacataccaa ggaacttcat tggacatggc
     1081 tgttttccat tggatacggt aattattctg cgcaccgtat ccgatgacat tggcaaccgt
     1141 caatgctaaa tctacttctt ctcgatattg tagagttttt cctttaatcc gagtagtacc
     1201 atcattgaca gtcacttcat agccacgcgc ttccaaggcg gatttgagat tatctactac
     1261 ttctgtactt gccgccataa tcccctcttt ttccccttct aagtaatata agcggatcct
     1321 tcgatgagtt tcagggctga ttggaagatt gtgttgggta tctttcaaaa gagtaatcgc
     1381 cttatctgcc gcctcacgtt gccaagccaa atgttcttca catccaataa ttgccaactc
     1441 atcagcggat ttcaacagag tcccttctgc ttgtttgaca tgaagattga gtttggcttt
     1501 caatcctaaa atgcggcgaa gagcatcatg aagacgttct ttggtaatca cgccatttct
     1561 gtaaccgttc agcataaact caaaatcttc ttccaggtta ttgaaaaaca agaacatatc
     1621 acaacccgct gcaatggcag ctggtacata gtcttcgcga cgcatagccg ctgtcatccc
     1681 cagcatgtga ctggcatcgg taataaccaa gccattgaat tccagttttt ctttcaataa
     1741 atcttgaatc aattcgggag ctagtgttgc tggtaagata tcctcatcct ttaaactagg
     1801 gttcaatttt tgttgataat atagcaaggc gatatgacca gccataacca tctctacacc
     1861 agcttcaata tggtggtgat agacacgacc aaaactatcg tcccactctt ctggtgatag
     1921 ctcattgaca ccgagaacta ggtgctgatc tcgctcttct gtcccatcac ctggaaaatg
     1981 ttttatgcat tgaataacat ctctttcggc agtcaaaccc tctaaatagg cgctggtata
     2041 agcaataaca tcgtcagcat tggtcccata agctctggta ttcacaatgg tattgcgcca
     2101 gttttgaacg atgtctacgc atgggtcaaa attgacattg acacccaatg cagtttcctc
     2161 cctcgcagat acaagacctg caagatatgg aatgcgagaa tcacgactgg cttcagactg
     2221 ggcacctgaa gaaatgtaag ttccaccttt cacagctcca tctccaccgg aatcacagtt
     2281 agctgcaaca aggagaggaa cttttgaata tgactgtaag tcattgataa gcccctgtac
     2341 ttgctcagga ctaccattca tataacgagc accgccaatg tggtatcgat taatcagctc
     2401 ctgattgctc agattattcc cgctaaaggc atcaccgcca aagaagaaga ggttgacaaa
     2461 aagttggcca attttttctt catctgtcag attttcaagg gtactctcta cccagacaat
     2521 ctgatcatca ttcaagtaat atggtttctt tcttaaatca actagtctag gcattgctgt
     2581 ctccttaatt cccacgccaa atatgtgtat ctaccaagcc acagtaagca tcaacagggg
     2641 acactcctgt aaacgatgat tctcctgcta gtttggtaac taaggtttcc aaagttactg
     2701 gtaaaccatc ataggcattg atataggttg ctacttgtgg catatctgcc agagcaaagg
     2761 gatgctgaac agaaacaacg atggttggta tttcatgaac atagaacggc tgatctggtg
     2821 ttcccttggc agcaggccaa ataattcgtt gagttgttcc acctgaattg acatcaacca
     2881 aattgataat caaatcatag ttatctgtga tttctgcaat aggacgctta gatgcataga
     2941 cattagcaat cgcagctggt ctttcttctt ctggtaattt ggcaatcctt gcttctgtat
     3001 tttcccagat agacacttcg tgacctcgtg cttctaacaa ttcttttagc gtatcagccg
     3061 ccctcttctt tcctgcatta atcatggcac caaagccacc tttgtagccg tcgacttcaa
     3121 ccaataaaat ccgtttatag cgatctggat tgactgggaa aatgccttct tgcttggatt
     3181 ttaccaaggt aatagccttg tcagctactt cttttgcaag atttttagcc tcatcttttc
     3241 caattaaagc cagcgcttct tcttttggca acataatttc ctgacgacga ccttcaaaaa
     3301 ggtggaggcc gagtttagct ttcaagccca aggtccgacg aagagcatca tggagccgct
     3361 cctcagtgag aagtccattt ttcaacccct ctttcatcca ttgcaaatct tcttcaggat
     3421 cattgaaaaa gaggaagaga tcgcagcccg cttcaatagc tgtcggtaag agctcacgac
     3481 gtggcataga tgctgtcata ccaatcatgt gactagcatc cgtcacaatt gcgccgttgt
     3541 agcctaactc cccacgcaac aattcatcca agagggtttt attcaacgaa gctggcaaca
     3601 tatcatccaa ttcacgttct ggatgcattt ctttctcaac atttggcaaa tgaatgtgcc
     3661 ccgccatgat acctggaaga cctgcatcag ccatttcacc gtaaatccgt ccaaaggttt
     3721 ccatccattc agattttgtc attggattag aagcaaaaga gaggtggtga tcgcgttcat
     3781 caataccatc gccaggaaaa tgcttcgcaa aaggcacaat gccatgttcc ataatcccac
     3841 gcatgtattc tttagacagt tcaatcactt ggtcaacatc tgctccccaa gtacgattgg
     3901 cgataattgg atttcgccag ttgcggctaa gatccataat cggtgcaaag gaagcgttac
     3961 agcctactgc tgctgcttca atccctgcaa ctttccccat ctcataagca tggcgagaat
     4021 cagctgttgc tgcaattttg atttcatcgc caatttttgt tccatctgta acagcaccat
     4081 ttccaccaga ttctgtgttt gctgctatta agagaggaat tttggactta gtttgcaaaa
     4141 tatagttttg ttcccaaata tctgccgctg gccctggatt ataccgaaca gcagcaatct
     4201 tgtaatcttc caatactcct gtcagatatt tctccgtccg ctggataccc atgttgacaa
     4261 agagatgtcc tattttttca tccaatgtca tctgagcaat cgtattttca acccatgaaa
     4321 tagcttcttc atcaaggtta taaggtttct tccgtaagtc taccaaatgt gtcatcgttg
     4381 cctccaaaaa agctagaggg catgtagcct ctagccctta tctagtcgtc taaatttttc
     4441 caaaatgctt gtatcaagtt tgtttctttc tcacctgcaa atgtttgatt aacaaagtca
     4501 tctgcaatcg tttctgttaa atctgcccaa gatcgcatct cccgtcctac taaaatagga
     4561 tagaagtgga cattattcag ttctgcagcc ttcaaatcac caggagaatc accaatcatt
     4621 atgatgttat cagggttata acccttatca atcaataact ttatcacatc ctccttcttg
     4681 cctcgatctt gacaataaag ttcagtaaca aaatccagta atccttgctc ggaccactct
     4741 tcgtcgaccg cttctttatt ggctgaagaa acgacatata cttttcccaa ctggctcaat
     4801 ttttccaagc ctttgtgaac gccgatgaat gctaaaacag gaccagtata gttcttaata
     4861 gcttgattga cttgtttgga ccattctaaa gctaattcta aatctttcga tggttgctcc
     4921 gctatcagct tttccagaga agcatttgac aaagaatctg tggtcgcaac ccaatttttc
     4981 aactgttcaa taccagtcac acctgcaaat tctaaacctt taaccaaccc gacaaaacgg
     5041 ttaatgccac gtgttcgtga atagagattg actcgattcc attccgttaa gaaagcctcc
     5101 ctatcttgaa ctccaaagac atctgctgcc aaggggccaa agaagagctt atgtttgtag
     5161 gtcatggtgt ccattgcaca gccatcagag tccacacaaa atacataatc tgtcttcatg
     5221 attagactcc tgaataggct gaaaatccac cgtcaatcgg taaaacaacg ccatttacaa
     5281 aacttgccag attctcatct gctaagaaga agacacctcc aactagctct tctgcttcgc
     5341 caaaccgtcc catcggtgta ttggtcaaaa tcttgttggc acgtgctgtc ggttgacctg
     5401 actcatcaaa taacaagccg cggttctgat tggttaaaaa gaaacctggt gcaatggcat
     5461 tgcaacggat tccaactttt gaaaaatgca ctgctaacca ctgagtaaaa ttgctgatgg
     5521 cagctttggc ccctgaatat gctggaattt tagtcaatgg tgtgaaggcg ttcatgctag
     5581 aaatattaat aatatttgct ccgctacggc caatcatatc ctgcgcaaat acctgagttg
     5641 gcaagagagt acctaaataa ttcaaattga atacaaagtt gattcccgcc tcgtccaaat
     5701 caaagaaagt tttggtgtcc acaggaagtc caatttcatg aaactcattg tccgtcgttg
     5761 ctttcggatt gttgcctccg gcaccgttaa ccaagatatc aactggacca aaatctgcta
     5821 agacttgttg gcgaacttct tccaaatttt ccttagaaag aacgttagat ttataggtct
     5881 ttgcaactcc acctactgac tcaatttcat caacaaacac ttgagcagct acctcattta
     5941 agtccaaaag agctacttta gcaccagcct tcgcaaattc ttttgccaaa taaccacaaa
     6001 gaacgcctcc agctccggta ataacaacaa ccttgtcttt aaattcaata acacgtgtca
     6061 taactagccc tccttattcc caactgtttt tactttaatt ccaaaatctg gtgtcttacc
     6121 tgccgctcgc atattcgctt cgtagagacc gttaaaatag gtcgcaccga gtgcacggtc
     6181 atacaaacca tagccaggtg tcttagtttg gtctccccag atacgtcgac catggtctgg
     6241 tcgcaaagct ccttgccaat catagtccac caagagttta actactccat tcatatcaat
     6301 atcgccagac tgtgacaagt gtgcagtttc ttggaagccc caagcccctg ccgtcacatt
     6361 acgagtgtgc ataaaattga tacggttgcg tttgagagca tattctgtca tggcgaggac
     6421 atcatttttc ggatcagaag cataggaacc gacacacatg gtaattccat tatgttctga
     6481 gtcatagaga ttcaaaaagc gttcaacagc ttcttgacca gtaatgatac gtggcaatcc
     6541 aaaaattcca tacggaggat catctgggtg aatcgccatt ttcactcctg cttcctcagc
     6601 cgttggcata atcgccttga tgaaatactc caagtttgcc cataaatctt cctcagaaat
     6661 attctgacga taattttcaa taacgttctt catttcttcc ttggaataag atgaatccca
     6721 acccggcaag ttcaagtcat ctgccacagg atcaacacca gctaaatcag atttcagaaa
     6781 ggctagggaa gttgaaccat ctggaagagg atgatgcaag tccgaacgtg tccagtcaaa
     6841 tacaggcatg aagttgtagc atacaactgg aattcctgcc gctccgacat tacgaataga
     6901 tgttttatag ttttcaatca gctcatcacg gtttggtttg ccttgtttga tatcttcatg
     6961 gacaggaatg gactcaataa ctgtaatctc taaacctgcc tcttccacca tttgtttcaa
     7021 ctcaagaata ttttccaaag gccaagcctg acctactggc acatcgtaga cagctgtcac
     7081 aattccctgc atgccaggaa ttgctttaat ctcttcaagt gtcacagggt ctttttttcc
     7141 ataccatcga aatgacattt tcatgattta ctctccttta ttgttcaaaa aactctttgg
     7201 cattgtagta agatattgct tctacaaact gacctaggcg atcatagtcc tcaggcactt
     7261 cctcatccac aatccattgg ccaacatagg tcgccaaaat tcgtctgaaa taatcatggc
     7321 gttggtagga caagaagcta cgcgaatctg tcaacatccc tacaaaatta gcaagcatac
     7381 cttgctcggc ataggcattc atctggtcaa tcatgcctag cttggtatcg ttaaaccacc
     7441 aacccgcacc aaactgcaac tgactacgac gcccttcctc attggcttgg aaatttgcta
     7501 aggtgttggc tagggcaata ttgtagcctg gattaaggtt gtaccaaatc atttttggaa
     7561 gggcattttc cttgaccaag ttgtccaaca aacgattcaa gttccccgtc aagcacgtct
     7621 ggtctccaat cgaatctaca cctacatctg ctccaagttt ttcaaacagt cctgtatggt
     7681 tgtttcgtaa ggcaccaaaa tgaacttgtg tgacaaatcc atgtttcttg tacatacgac
     7741 agagttctct aaaaatagct gtctgccact tattgatccc agattgtccg acctctttcc
     7801 ctaccatcct agcaagtaaa atatcattca gttcttcaag tgtagcttct tcataggtaa
     7861 tagctgtaaa actaatatcg cttgctcggc aaccatgttg agcaaaatag gaaactcgtt
     7921 ggcccaaagc ctctacaaaa ctggcaaagt ctcttactgc tacctccgtc acttcttcca
     7981 agcgtttaat aaataaattg aaatttctgt gttctataaa ggcttcatct ggacggaagg
     8041 ttggcgctac tacagtgtca atgggtgaat cttctgccaa acgcttatgc cattctaggt
     8101 tatcaagagg atggtcagtt gtcccgataa aggccactct ggcatcagcg atcagcttac
     8161 gtggactaat ttgatgttct tgcaaatagg tattgagctg atgatagaga cgctctgcat
     8221 tttcttccgt cagcaattcc tcgataccaa aaacttgtcg taattccaaa tgactccaat
     8281 ggtagagagg atttccaaaa gcacgttcca aagttcttgc ccaggcttta aatttatcta
     8341 acttacttgc aaatcctgtg atctcttctt ctgaaattcc attagcccgc atcaagcgcc
     8401 acttatagtg atctccacct agccacaaat caacaatatc ttcatagacc ttgtcttcaa
     8461 aaatttcctt aggatccaag tgacaatgaa aatcatagat aggtagctct gctattttca
     8521 cgtaaagctc cttagcaggt tcatttttta gcataaagtt tttatcgtta aaactcatct
     8581 tatccctcca aagctgctac aaaactacga gcaatcaacg ttacactgtc atagccctca
     8641 gcctgcaccc gactcgccaa tgccgaacca attccaacag cacaagcacc ggcctttttc
     8701 caatccgcaa cattgtcaac agatactcca ccagatggca tcaagtccac ttcagggacg
     8761 ggaccgtgaa tatctttgat aaacccatgt cccaatacac caccagggaa aagcttgata
     8821 atagaacacc cagcctgact agctgtaaca atttccgttg cagttgcaca accaggaaaa
     8881 tagagaaccc ctgtctcttg cgctaactct tggattttct tatcaaaatg aggactaaca
     8941 agaaaactag cccctgcacc aatcgcctcc tgtgcgagat taagattcat tactgtgcct
     9001 gcaccgatga ctacagacga atcatctgag aactcttctt gtaattcttt gatgactgtc
     9061 gcagcattag gcgtcgaaaa tgtaatctcg atatttcgaa taccacctaa aaccgcatga
     9121 cgagcaattt cttttgcatc ttgttcatct tttccgcgaa tcactgcgaa aaagtaattt
     9181 tcttttaatt gtcttaacat cttaacctcc aattagaaag cgttgctatt tatagttata
     9241 gtatataatt catcagatga tttgtcaagg aaaaagcaaa aaaataccca gaagactctt
     9301 ctgggcagtt cgttttatat ttctatttat gatcatttag accatgcaag gtcatgtctt
     9361 tatcgaacca ttcgcttaaa acaacctgtc ttaccgatat aatatgcgct aacatactat
     9421 cataagctgc aacagggtgg cgttgtttga ttgccattaa gatatttctg tgcgcctgta
     9481 aactatttga tttcatctga cgatttgagt aattttcatt gatcagatga atggactgat
     9541 taatgacagg catcaggcta gtcattgcca gattcccact catctcagcc agcatacaat
     9601 gaaatttcac atccaactcc aaatgcttcg tgtctccagc agctacagcc tcttcaattg
     9661 caaggacaat ttcctctaat ttagcaacat cttcatccga agcaaattga gctacacgct
     9721 ccgcaattct cggttcaagt aagtaccgca cttcaaacaa atccgttgtc aacttcacac
     9781 ggtctcttac caaagaaaaa cctagagggt cttccgatac tcctttttta gagctgatgt
     9841 atgtccctga cccttggcgc acctccagaa tattgcgagt agccaaactc cgaacagctt
     9901 cacgaacagt cgaacgtcca acttctaaat cttgggctaa ttcatactca tttggaagct
     9961 tgtctccaac ctcatatcct ctttccaaaa tcaattccaa taagcgttct gatgcttttt
    10021 ctaccaaggg tttcgccatg tgcttggtcc tccaatacaa ctttctattt gctactatta
    10081 tagcctattt ccttttataa tggtagtttg gaatggcagt ccaacgtttc tttatttctc
    10141 taacaatttg cttgggttga cgattccgtg agaataaacc cttatgattt ccttgaatcc
    10201 gaatgagacc aactgtggtt tcaaaatcag caaaattcca gacttgttca ccaaccacat
    10261 ttgaaataga atcaaaaacc ctgtgattca tatcatagta atccacttga aattcttccg
    10321 tataaggaat atcccacatt gaatgcaagc ctgggagagt atctgcacca tattctgtaa
    10381 tcaaaatagg cttgtctgga tatagttctt gccatgtctc tagttccttt cgaagtcctt
    10441 tttctgccat cttcaagtcg ccatgagcag cataccaacc ataataacga ttgagacaga
    10501 caacatcaac caagtccata acttcatctt tatcaggtgt tgccgtcata atattaacca
    10561 aggttacagg acggttagaa ggatctctat ctctcattcg ctgaatcaga ggttcaaagt
    10621 aagcacgtgc acctttttca tgccctgccg gttcattggc tacaacccac atcactacgg
    10681 atggatggtt cttatcacgc gctatcaatt catcaatcac tagttcatga gcatccttgg
    10741 tttgcatgac ttcccaggta ttttttacct catcagaatc ccctgtcaaa ttcaaggctg
    10801 cattgaaaag ctggaacagc ccgactgctg gcacctcgtc aatgactaca attcccaatc
    10861 gatctgccag tcgcatcatt tcttcagaat atggataatg ggacgttcta aatgaattag
    10921 ctccaatatc tttgagtaag ttcaaatcca tcagattagc tgcttcgttg aagccgcggc
    10981 cattgataaa ggtgtcttca tgtttaccaa atcccttgaa atagaacggt tttccgttga
    11041 tgaaaaattg tccattctca actgcaacac tacgaagacc aaactgttcg cagtaagtat
    11101 ctaataagct ctcaccatca aataattcga cttttgcagt atagagatag gcatctaaaa
    11161 cttcccaaag gcggggatta tcaatgacta tccgtccatt ttcaagaaga cctagttcct
    11221 gtccttcttg attaaaaatg tgaatacgaa tagaatcata ctgcccaact gtcgccacct
    11281 caacatgaac aacagcttga gtcaattcat tattcagttc agtccgaata acaatatcat
    11341 caaccctatt tttcggacgt ttatagagat gaacattccg ctgaatacca gcatagttga
    11401 aaaagtcaaa attttccttg accgtcttca caatttgacc gttttcatct acctcttcac
    11461 tgtaattccc tactggaagg gttgtataat tcagctcatt attggcacaa actgtcaggc
    11521 ggaattgatc caaaccatat aattccgacg gaaccaggca ttcaaaaggg gtaaagcccc
    11581 ccttatgctt cccgattaac tgaccatccg catagaccat agcctgatgc gtcacggagc
    11641 caaagcgcac cactaattct tcatcatcag acacagcagg gatagccacc atcagttcat
    11701 accaattatc tccgacaaaa cggcgtttct ctttgtcaac aacaatatca ttgaaggaac
    11761 ttggtacaac cattacctca tccgtatcta acaaagattg aacatcattg tttccttgct
    11821 taaaggccca tattccgttt aaagaataaa ctgagcgtgt tttcgtttga attggataca
    11881 acatattttt cctactttct atcgttttat ttcacgagac ccttttttca ataacaaatc
    11941 aatatctgat tgactgatga cattgacatc cccttcaatg gtatgtttga attgaaaact
    12001 agccattcct aagtctacta cttcctgcgg cgatttttcc tgtaaatagc ccaaaataat
    12061 tcctgccgta aaggcatcac ctgtcccaac tcggtctaaa acttgaatgg attccttttc
    12121 tgtttcgtat agaacaccat cttgatacaa ataagctttc agcaagtatt cattattgta
    12181 ggtcatttct cgctgggtaa aagcaatgct ttgcagagaa taggtttctg ctaaagcttt
    12241 aacgactgac aataggattt ctctattttc ataagatcgc ttcaagccca gttcatcctt
    12301 catatctttt ccagattcat ttaggagttg gataggctct agaccaaagc aaatatctgc
    12361 caagcctaca aaaggagata acttctccct agcttcctca aaagaagacc acaaactttc
    12421 ccgataattc aggtcaaagg aaaccttaat accttgctcc tttgccatct ccatcaaacg
    12481 aaaggccagt tgacgaataa ctggattcag ggcaactgta ataccactca catggaacca
    12541 atcaacatct tcaaatatgc cttccaaatc gtaatcttct tcccttgata ggctaaaagc
    12601 agaataatca cggtcgtagg tcacctgact gggtctaaga gaaaaacctt tttgataata
    12661 ataaagtccc agtcttccct cttttcgaat caaatatttc tgtccaatct gacgtgcaaa
    12721 gagaaaatgt tctgccattt tgcctacttc attcctaggg agtgccgtca ccaactcgac
    12781 tgaatgaccg agctgagcca aactagccaa aacatttaac tccgaaccac caaattgaca
    12841 ctccaagctc ctagcctgtg tcaaagtctg ataatgtggg ggagatagtc gcaataaaac
    12901 ttctccaaat gctaaaattt tcttcatacc gcctcctagt tgaaagaccc agctggaagc
    12961 ctccaactag gtcaatcatt gtactattta cattcaaaaa tcttatttat cttcgtattg
    13021 ttcaacctta tactgagtta catcaacgta gtccatatca gatagtggaa catttttcgc
    13081 aatagcacgc actcgttctt catcttttgc cgctttcatg acatggattt tctcttgaat
    13141 acgagccatt tcttcacggt ctagtttgta gaatttcatc aagaacaagg atacgctcaa
    13201 taccgctgct ggaattactg ttaacaagac aattagtgcc attctcaaat cagttgagaa
    13261 agctgtttca acagttggat attctttacc aaatccaata cctgctaaca caaaaccaac
    13321 aaccattgga gcaaatgaag acgcaattga gtctgtcaat gagaagatag taccaatcat
    13381 acctgacaag taacgaccag atactgatgt ttcatagtct gtaatatctg cacccattgt
    13441 caataccaaa ccggatggag cgccagatgc ataacgtgca atgatataaa caacaaagaa
    13501 accgattgtg tagagattcc aatttgttaa atccaacata ccaggttttg ctgaaaacag
    13561 catcgctgcc aaggcaacaa gaccagcaat acccaactga agcgctgtaa tataggcaaa
    13621 gcgtaaacct ttacgacgag ccaactgtgc cgcaccaact gttacgagga taccaggcaa
    13681 aatcaagagc attgacattt ttccagaaag agcatagtca ccgaagataa taccataaag
    13741 cataaccccg ataactgaat caccgaacaa ctgagcaaca aattttacaa aggctgcaga
    13801 gattgaaagt acctgcaaag gtttatttcc tttgataact ttccagtagt ctttcaactt
    13861 agtttcttgc gttttttcgc caagaccaaa gtatttctta ttgtcttttt cccaaatacc
    13921 gataatagca aggataccca gaatagctga aataatcaca acaccaagga acaattcttg
    13981 gaagaaactt ggtgtgaagc caccatgttt aggaaccaat gttcctgata caacaacctg
    14041 actaccagtc atcaatactg ttgttgcaat accgtcaaca atattgaaga ttggacgttg
    14101 tttcggatca ttggtaagag caacctgtcc cgctttcgta atagtctgtt gcaatgaata
    14161 accaatttta tggataatca aaacaagtat aaacaaggga agacggagat tctcactaac
    14221 tccacttaag cccaacatca tgaaaaggga actagccgta atgatattcc ccaaaaccaa
    14281 gataggacga tatttaccaa acttagtatc tgttttatca ataataacac caattgttgg
    14341 atcaatgaaa ccatcaaaga tacgaatata gcccatcagt tggctaacaa acagcgctgc
    14401 cagaccaagc acacccgtcg ataaataagt cacaaaagta aaggcaacca agtaaatatt
    14461 cgtcgacgaa ttattcatcg caaataagat gatttgccat aacttcgctt tgttataagt
    14521 aacgtcttcg acacgttgct caacatgttt ttccatcgga aattcctcct aaatgttttc
    14581 tacgacaaag tcgtaagcgt tttctttaac tatattctac tattcgtcag atgatttgtc
    14641 aacagttttt gtaaatattt ttaattatac gcaaaaaaag acgattttac gtaaaaatca
    14701 tctgatatat tttatttaaa cacagccaat tcgtctgact atttattgat ttactgtaat
    14761 ttccccacta tggtagttga tactgagacc gctctgcaca ttgggaacaa aaacattgaa
    14821 ctctaggctt ccatctgccg cttttgcttc tagctgactc cctacaggaa ccaggtcatc
    14881 tgcctctgca tagaccaagg ttacacgata gcggacacgc ttatttttat ccaaagcgcg
    14941 tcttatttgg ctctcagaaa aattttgacc cgcagagctt tggtcattag cttggttaga
    15001 ccaagctgtt tgaacagcaa tgtttttata gtaaagtgaa ataagaatag gacaaatcaa
    15061 tcaggacagt caaatcgatt tctaacaatg ttttagaagt agatgtgtac tattctagtt
    15121 tcaatctact ataggattgc tggtcgaagc atcaaaacct gaaagtccac caatcaaggc
    15181 atagcccaga aggtgacctc ggtccactgc atggtcatat tctccagtta agtcatggac
    15241 ctgatgccaa ccagcaggtg tccaagaagt ccgaccattt ctagtttctt cacgatcctt
    15301 atactgacgt gtagattttg ctaaaagcgc attggctact gtcggaatag tttctccctg
    15361 caccgttttt gtcttgttgt ctccgtaagg aacacttgca acagaggcat ttaaatccgt
    15421 ctgattatcg ttaataataa aggctccagc accattccat tcaatagaat tccccagttg
    15481 ctttttgact tcttctgtca ataccgaact agctagttcc tgactaggag tcccttcact
    15541 cgccttagac tgattgacat aataggaata attggcagga gtgctactct ggctatcact
    15601 taaaagataa ccacccgcta ctgcaattat agtcaccagt aagctcattg cctgtttttt
    15661 caaatttttc ttcgccattt tctctccatc aaaaaagcag gaccagccta ctttcctgta
    15721 aatttaccga ttaattcctg ccacttagca ggtgacaata ccgcaaatac attgtcacca
    15781 tcacctatga caccataacc aagcactaat cctaacacaa ataccaaagc agcaattaac
    15841 aaaacaatta ccaccaagag caagtttttg ccaacatagc tgagattttc cttatccatt
    15901 ttcaacttct ccactcacgc gttcaaatat catttttgag attaagaatt gtcaaaaaaa
    15961 atagctagca aggaaaaacc aacaaatagc atccaagtca actgcatgtt ccatacggct
    16021 actagtgaaa aacaagctgt tcccacaggt atggataagg taaacaatag accgaaaaaa
    16081 ttactagtac gagctagaac ctctggagct agatttttca tgagcatggc actaatcttt
    16141 ggttgaactt taccagacac atacagagta aagaagagaa atagcaaacc aagcacgact
    16201 tgattgaata aattagccaa accaactaga ctaagtccta cggtctccca catcatcaat
    16261 ctaggcaagg actgcttccc aaaataatca ttgcccgtaa ggctactgat gataactgct
    16321 actaaaacac agaattgatt gataaatagt gcctctgtat aagaaaaatt caagagagaa
    16381 tggctcaaaa agaagatatt ataaattcca cccaaagcgc cacccaagga attaataagc
    16441 aagacagcaa agagcataaa accaaagttt ttctgtccac ttttaagaaa aacgagacgt
    16501 aaatttcggt aaattgttag gaactggtct ttgatagaaa gcttctcatt ttttagtttt
    16561 tcaccatcag cagatgacat tgacaggctc aatttgcttt ttcctaaaaa gaggatgacg
    16621 gctgatacta ggaagaaaca ggcattgatt cccgcaacga gggaaaaatt gttgaccgat
    16681 agacctaaga gccagactcc aaaagcttga ccaccaatag ctgaaatata ggtgataaac
    16741 tgggaaaaag aataagcctc catcaaatca ttttcagcta ctttttcctt aataagaggc
    16801 atgcgcaggc cacctgcaaa atcactgatg atatcactaa tgacattgat caaacacagg
    16861 ctagaaaagg caaagagact agcttgctga acaactaggg ctgctagaaa aaatagaacc
    16921 gcctgaaaca aaccgctata gaccatccat ttgaccttgt ccctcgtgta atctgcccga
    16981 atccctacaa aaactgtaaa gagggtcgga agaatcatga caatattcgc catagcaaca
    17041 gcaaaagatg cttgtgacaa ggtcgatgca tagacgataa agaccaggtt gaaaatcgaa
    17101 gcaccaaaag cattgaagaa gcgtgataaa gtcaaaattc tataagctgg atttctaaac
    17161 aatagtttca tagataatct cccttcttgt tctaagttct acatcaagaa tagctttagt
    17221 atagcactta tgaatttgcg aaacgattct tttgaatata tgcaacaaac aaaatgagca
    17281 aaaaaacgat agaacttttg taatgacctg agagagggca acagttctat cgcttcaaat
    17341 tttttcttgg tttgcagata ctcaacattc ggtcgtattt ctatagtatt cggcagattt
    17401 attacagcca agcatctcaa aaatacggac agcatcctcc atctttttct gaccttcctt
    17461 gactctacct tgcttgctat caaggagacc ttctgcccac agataaacaa ttcggaaata
    17521 ggtctcattt cccttgtaga aatgctcttc gataacacgt ttaaaataat aggcattggt
    17581 aaattcttca cactcaatac tagctaaaaa gccattcaat agtatagtat gaaaaaggtt
    17641 tcgattgcca gacatttcca ttagaaaatc agatttatgt accatttctc gtacatatct
    17701 agtaaaaaga gaaacagata aaaatggaaa actgactgaa aataaattga gttcatagat
    17761 tccccagatc tcggtagaaa acaaataatc atgaaggact tttccttcct ctgctgttaa
    17821 ctctaccctt tcatctatgc tcttcatata agacttgata ataatggcat ttagaatatg
    17881 tttctgtttg ttgtgagaat gggcatgctt ttgatactcc ctgcgatata agtcctcaag
    17941 aggtgctata ttctttggtt ccaagacatc tgtaatttct tttctcaact cagaatctgt
    18001 atcatactgg aaacctctcg ccagaaagag gatctcctcc acactggcag atatattttc
    18061 cagagcaaat agaaactttt ccaccgaaag ctcactctga cctgtttcaa aacgggacaa
    18121 catagacggc gaaaattgtc ctccggttgc ttgtctcagt gagatatttc ttgactctcg
    18181 taattgtcta aagacttttc caatctgctc catagacttc cccttgattc cgtattttct
    18241 tcattttatc atatttttca gaaaattcat caaaaacttg ccaaattgtc agaattatga
    18301 gaaaatagag gatatttatc acgtggaggg actgctatga gagacgatat caaaatcaat
    18361 gaccgtgctt tggccttgca agaccaaatt atcgaaaaac tagagaaagt ttttgataca
    18421 gatgtggaat tggatgttta caatctaggt ctgatttatg aaatcaatct ggatgaaacg
    18481 gggctctgca agattgtcat gaccttcacc gatactgcct gtgattgcgc cgaaagcctg
    18541 cctattgaaa ttgtggcagg tctgaaacaa atcgagggta tcaaagatat caaggttgaa
    18601 gttacctggt cgcctgcttg gaaaatcaca cgaatcagtc gctatggccg tattgccctt
    18661 ggactaccac ctcgttaagc aggccaatca cttttaaaga tgaaaaaagc aagccgaaaa
    18721 tggcttgctt tttgatactc aatgaaaatc aaagggcaaa ctagaaaact agccgcaggt
    18781 tgctcaaaac actgttttga agttgtggat agaactgacg aagtcagctc aaaacactgt
    18841 tttgaggttg tggatagaac tgacgaagtc agctcaaaac actgttttga ggttgtagat
    18901 agaactgacg aagtcagtaa ccatacctac ggcaaggcga cgttgacgtg atttgaagag
    18961 attttcgagt atgagtttat tttttacctg acttgtccat attccagaag tctgtcacgg
    19021 ctccgcgtga agcagatgat acgatgtggg catatttacc gaggacacca cggctgtaaa
    19081 gtggtggcaa ggttgtttct gccttgcgtt tttcaagttc ttcttcggat acggccatgg
    19141 aaatttcttt ggtatcttgg tcaaccgtaa cgatatcgcc ggtacggaga taggcaattg
    19201 gtccaccatc ctgagcttca ggagcgatat gtccaacaac cagaccataa gtaccaccag
    19261 agaaacgtcc gtccgtcaag agggccacct tatctccctg acctttacca acaatcattg
    19321 atgaaagtga cagcatctca ggcataccag gaccaccttt aggtccaaca aaacgaacaa
    19381 cgactacatc gccatcaacg atttcatctg tcagaacggc ctgaatcgca tcttcttctg
    19441 agtcaaagac cttagctggc ccaacgtgac gacgcacttt aacacctgat accttggcaa
    19501 ctgcaccgtc aggagcaagg ttcccgttca agatgataag cggaccatcc gcacgttttg
    19561 gattttcaag tggcatgata actttttggc ctggagtcaa gtctgcaaag tcagccaagt
    19621 tttcagctac agtcttacca gtacatgtga tgcgatctcc gtgaaggaaa ccatttgcca
    19681 acaagtactt cataaccgca gggacaccac cgacttcgta gaggtcttgg aagacatact
    19741 gaccagatgg tttcaagtcg gccaagtgag gcacacgttc ttgaatcgta ttgaagtcct
    19801 caagtgacaa gtcaacattt gcggcatggg caatggcgag caagtgaaga gtggcgtttg
    19861 tagaaccacc gagagccatc gttacagtga tagcatcttc aaaggcttca cgagtcaaga
    19921 tatctgatgg tttgagacca agttccaaca tcttaacaac agcacgtcct gctgcttcga
    19981 tatcttcttt cttatcagct gattcagctg ggtgagagga tgaccctggc aaactcatcc
    20041 ctagaacttc gatagcagtt gccatggtat tagcagtata cataccacca caaccaccag
    20101 ggccagggca ggcattacat tcaagacgtt tcacgtcctc agctgtcatg tcaccgtggt
    20161 tccattttcc gataccttca aagacagaaa ccaagtcgat atctttacca tcaagatttc
    20221 ccggtgcaat agttccacca taggcgaaaa tagctgggat atccatatta gcaatagcaa
    20281 tcatagatcc aggcatgttc ttgtcacagc caccgatagc gacgaaggca tccacgttgt
    20341 gaccactcat agccgcctcg atggagtccg cgatgatgtc acgagatgtt agagagaaac
    20401 gcataccagg cgttcccata gcgatcccgt ccgctacggt aatggttcca aactgtacag
    20461 gccaagcgcc tgcagatttg acaccttctt tagccagttt cccgaaatca tgcaagtgaa
    20521 tgttacatgg tgtattttcc gcccaagtcg aaatcactcc cacaatcgat gtttcaaagt
    20581 ccttatctgt cataccagtc gcacgaagca tagcacggtt aggtgattta accatgctgt
    20641 catagatgct actgcggtga cgtttatcta attcagtcat cttatccctc ccatttcagt
    20701 ttttactatt atagcacaat ttaaaggcaa tgaacagaat aaaattcttg aattttcaga
    20761 aaattctata cgcatgtgaa atatttaaaa ttaaaaacaa caaagcggat tagtgcactt
    20821 tctgatgacc agaatatgct ttttaatccg ctttctttaa ataacgtaat gtaattttta
    20881 cagaaattct ttcagataag tgtatttaac atctatcttg cattataaat ttctagaacc
    20941 ttctctttta tattcgattc actcaaacca tactcattaa gaagataatc cattttccct
    21001 acttgaccaa atctttcttg aacacccatc cgatgaattt ttgttattcc atcatcagag
    21061 aataattcac ataaagcact gccaattcca cctatctgat tgtggttttc tacagtaaat
    21121 atagtttttc cacttaacat tgtttttatc tgttctggta tcggtttgat tctaaataaa
    21181 tctatcacac ctactgaata acctaattta gacagttcat ctgcaactcg aatacttgga
    21241 gcaaccatta taccagaagc aacgattaca agatcttcac catgccttaa ctcaatgtag
    21301 cctttagaaa aatcttctcc accttgatac acaggaactg gagcttttct aattgttcga
    21361 atatatttta atccttttaa gtctaatgtc tggttcaata tttcacgaaa ttggatatca
    21421 tcagttgctt caaaaatgat cgatttagga attaaacgta acaatccaat ttcttcaaat
    21481 ggcatatgtg tcccgccatt catttctgca gttactcctg catctgatcc aatcacagtg
    21541 gcatccaatt gtgcgtatcc aagagaaata aataattgat caaatactct tcgtgaagca
    21601 aaaggaccaa atgtatgaag ataaggtcta aacccctgaa tagacaagcc tgctgcaagg
    21661 ccgaccattt ctgcttccat aatcccaaca ttcacataac ggtctccaaa gtccttttca
    21721 agattatgag tagccatcga acttgacaaa tcggcttcta agactactat atcagaatca
    21781 ctttgattag cctctaaaag gaagtctcta tatacatgcc gtaattcttt cgtacttctc
    21841 atcattctgt ttcctccaat tcctgactta atctttctac aactgaagtt aacatttgtc
    21901 tctcctctac agtagggcga agatgatggt tggatttcat ttcttccagc tcttgaaccc
    21961 cttgaccttt aatagtatct aatacaatgc acttaggtga tgaattattt gactgtttta
    22021 attggacaat cccttcataa atttctctaa tatctgaacc cttgacccta atggattcaa
    22081 atccaaatgc tgaaaatttt tctacgaaat cacctggatt acaaatatcc tttgtaaaac
    22141 catctaattg ttttttgtta tcatcaacaa atacaattaa gttggataac tgttgatgag
    22201 aagcaaactg tatagcctcc caacattgtc cctcatttaa ctcaccatct ccaacaatag
    22261 cataagtata aaagggactc tttcttattc tctgaccata tgcaagtcca gttgcaacac
    22321 taattccttg tcctaaagag cccgttgtca tatctatgcc tggcgttaga tttctatcag
    22381 gatgagacgg taatttggtt ccatttttat ttaaagaata taagaattct ttgtcaaaga
    22441 aaccattcaa atagagtgta ctgtatagag ctggtcctcc atgacctttt gataatatga
    22501 aataatctct atctcgtgct gcaaatattt ctggagtcat tggcattatt tcaccataaa
    22561 gcactgctaa aacttctacg atagacaaac ttcctccgta atgtccgaat ccaagatgat
    22621 tcaatgttct aagagtattt aatcggatgt tagtcgcaaa ttttcttaac tcatcttctc
    22681 tatttttact taaaatcatc ccttattcct cctttgcaga tggcttttta ataaaggata
    22741 ctccaaacat aactgctaaa ataagaacaa gaccaatcac aatgcctgct tgtgagccaa
    22801 attgatttaa cattcctaaa ataattcctg atagaccaaa atctgcatct gagaaagttg
    22861 atccttggaa accgagtcct cccaaaactg gcattaaaaa gactgggaga aaactgatta
    22921 aaataccttg taaaaatgct ccaatagtgg ctccacgaac accaccagat gcattcccaa
    22981 tgacacctgc agtcgctcca cagaagaaat gaggtacaac gcctggtaag ataacaaccg
    23041 ttcctgaagc aatcataatt gccatactta ctaaaccacc aacaaaacta gagataaatc
    23101 caattagaac tgcattgggt gcataagtat aaacaatcgg acaatccaaa gcaggttttg
    23161 aattaggtac aagacgctct gaaatacctt taaaggctgg aacaatttcg cccaaaataa
    23221 ggcgaacacc tgctaaaata acaaataccc ctgctgcaaa ttgacctgct aattgtaaag
    23281 cataaactag accacttgta ccactactga tttctttttc tatatattct gaccctgcaa
    23341 agatagctac aataatgtaa ataactgcca tagataaagt gatactaaca gtactatcac
    23401 gtaaaaaagc taaactcttt ggaaatttaa tgtcctctgt tgattttgat ttgtcaccga
    23461 taaggctacc agtaaaacca ctcaaccaat atcccaaaga actgaaatga cctaaagcca
    23521 ccttgtcatt tccagttaat tgaaccatat atttttgcac aaatgctggg gaaatactca
    23581 taataatacc gagtgctaat cctcctagta agataagagg caagctagta aagccagcaa
    23641 ctgataaaat gaccgcaatc atacatgcca tatatagagt gtggtgccct gttaaaaaaa
    23701 tatatttaaa tcgagtaaaa cgagcgatta agatattgaa caccatgcct gcaaacataa
    23761 tcagtgcagt agctgagcca tatgttgtta aagctacagc tacaattgct tcattattcg
    23821 gcacaacgcc agataaatga aaagcatgct caaacatggt accaaatgga tttaaagaat
    23881 tttgtacaat tcctgcacca ccagatacaa ctaagaaacc aacaaaggtc ttaattccac
    23941 ctttaataat atcaggtaat ttcttcttct gaagaactaa tcctaaaatt gcaattaaag
    24001 ctactaaaat agctggtgta ctaacaatat ccaatatgaa cttcatcata acgctagcct
    24061 cctatataag tcctttttct tcacaaagtt tagtaattaa ttctcgtagt tcatccatat
    24121 caataatact atttaagata cgaacatctc caagatgact agctgaatca gctagatcac
    24181 gaccaacaat ccaaatatca gctgcatttg gatctgctcc acctaaatca taatgttcaa
    24241 cttctacatc cgaaacattc aaatcactca atacagattc aatattcatc tgtaccataa
    24301 aacttgaacc taatcctgaa ccacaagctg taccaatttt taacattatc taatcctcct
    24361 gtttaattat cattttaatg tcatcatagt tttttgatga tattaaagtt tgaacatgat
    24421 ttttatctct taaaattgtt gttaaatgtg acaaagcctt taaatgactc tcattatcaa
    24481 tggctgcaat acaaatcaac aatcttacct cttgttctgg attatccaat aaataaatcg
    24541 gttcttccaa aactaacatt gacattccta tttcattcac accttcatct ggccgagcgt
    24601 gaggaattgc tactcccttc cctaaattaa taaaaggccc aaactcttct actttttgaa
    24661 tcattgcctc agggtagttc tcagttatct tatcttgatc caaaagcggt ttagctgcta
    24721 aacgaatcgc ctccttccat cctaattttt gcgaactaac ctgataggtt tctttggtaa
    24781 tgagttgttc tagcactggt acaatttcct ttctatcatt tttttggtaa agataattct
    24841 ttaacgccaa tcttaattcc aattcttgtg taataattcc atatcttttg acaatattca
    24901 ggatttgttc aatctcaaaa tccccatact ctaaattcgg aaaatctttt aacactagtt
    24961 ctactagttg tattgcttgc tcttcagtca tcataaccga aactagataa tttggctttt
    25021 ctgtctccac ctttatggta gaaaaaacca tatcatagtc actactagct ttcacctgta
    25081 aatcatcaat ctttgaggtt cctataaact caatttgagg aaataatgct aatagattct
    25141 cttttaacat caatgaagaa ctaacaccat taggacaaat gattgctgct ttatagcatt
    25201 tttgaggcaa agtatctgct ttctttaaat aacctccgaa atggataaca aaatatgctg
    25261 tttcactatc aggtatggga ttgtcaatag cgtccatcaa gggcatcaaa gaatctttga
    25321 ctaattcaaa taaatcagga taatgttctt taacatgcaa tacatattca tttgaactag
    25381 gtaggccgaa ctttaatcta tagtaagccg gtataaggtg gcggcgaaga ttttctctca
    25441 atccttccct ttgtttaaaa tgtaacaaag aaatatcttc cattctactt ataatagcct
    25501 ctgttaattg attaaagtaa accggagcaa catctacttc accttcaaag caacttgata
    25561 ataaaacggt gatatagcga taatcatcct cagaaaacac cgtatctata attcccaaat
    25621 caaccactgt atccaataaa atagtcgtta tatcttgaat aacaggagat actaatgtct
    25681 ctgaaagaca tactctttca acatcccttt gatacctaca cagaatgaat actaaaccga
    25741 aaaggtaaac ttttaattga ttaacaatag gtactagctg tagcttctca taataatctt
    25801 taactacctg atcaatcaaa tcataagtta atgaataccc ccaactggat aaaacataat
    25861 ccaaacccca aatccctatg gaggattcca gcaactcact aaccatttga aaagctaaac
    25921 ggtgcttatt ccactctgaa ccgtgtaaag tataaccttt tgctctactg taccctagct
    25981 ccaaatcatt atctaacata atctttctta atgattgaat atcagataag gttgtattct
    26041 tacttacttt caaaaagtct tggtaatgat tattcgatat aaaatctaat cggcaaaaag
    26101 tgtaaagata gattaaagct aagcgagtcg actttggtaa aaccaattca tccgacttaa
    26161 taatatctgt caaagactgc ttcgtacgat ttgataaact atagcgacct tgctttttat
    26221 ccagcactat ccctttatta gctaaataag gcactaaata atctattcct tctttgactt
    26281 cctttatagg taagctcacc ttaacagata actcatataa tgatacctca caatgatcca
    26341 tcaaagtcat caaaataact agtgctctat aatcaaacat ttctcttcct ttctaactac
    26401 aattatagtg taaaagttat aagaataaaa gagtatttga gcacaatata atctcacctt
    26461 ttaaaagaaa ttattgggct gaaagttttt agtgattatt tttcaacttt ctattgactt
    26521 ttaaaaacaa agtgatatca tttagatatc aaataatggg aggtcattct tatgactgaa
    26581 aaactaatca attcaaaacc aaatggtgta ttcgcattga ttctcattga attgacgctc
    26641 gtacttggta tctttatatt tataatgggt gttggttcgg aaaacatttt tggaattatt
    26701 atcggacctt tactaatcgt aattgcaggt ctagctcatg ctggtttaaa agttgtcaaa
    26761 cctcaggaag ctctggttct gacactcttt ggtaattata caggtaccat caaagaacct
    26821 ggtttttact ttgtcaatcc cttcagcgta gcagtcaacc ctgcaaacca cactcgactt
    26881 ggacaaagtg gtgatgttag cacaaaatct ccttttttag gtgctaaatc atcaaatgac
    26941 aatgatgtaa atcttgaaat tggcaagaaa cacatttccc tcaaagtcat gaccttgagc
    27001 aattctcgtc aaaaaatcaa tgattgctta ggaaaccctg tagaaatcgg tatcgcggta
    27061 acttggagag ttgtcgatac cgctaaggca gtcttcaacg ttgataacta caaagaatat
    27121 ctttcattgc aatgtgatag cgccctccgt aatattgtcc gcatctatcc ttacgatgtg
    27181 tctcctaatg tggatactac gggtgacggg caagcagatg aaggtagtct ccgtggctct
    27241 agcgaaattg ttgctaaccg tattcgtgaa gaaatccaaa gtcgtgttga ggatgctggc
    27301 ttggaaatcc ttgaagcacg tatcacttac ctagcttatg ctccagaaat tgctgccgtt
    27361 atgcttcaac gccaacaagc atctgccatt attgatgcac ggaagatgat tgtagatggt
    27421 gctgtaggaa tggttgaaat ggcactagaa cggctcaatg aaggggaatt ggtagaactt
    27481 gacgaagaac gaaaagctgc catggtttca aatctccttg tcgttctttg tggcaatcat
    27541 gatgcacaac caattgtcaa cacaggaagt ctttactaaa gatggctgaa gctaaaaaaa
    27601 agcagatccc ccttcgactc tcaacaaagt tatacgctgc actcgcatca tgggcagaag
    27661 acgactttcg ttcagtcaat gggcaaatcg aatatctcct cacagagtgt gtcaagcaac
    27721 ggaagaaaga cggaaaatac gtatcagaaa ccattgacga accatttgag attgatattt
    27781 aacaccttct cctgtctgcc gtgtcggata ggagaatttt ttcatctttt tttgtcaagt
    27841 aactttactt tacaaaaaaa atgtgttatc ctaatatggt tgatgaaaat cagtagattg
    27901 aatcgaatat aaatacctaa aggagaaatc aaaatggcag tacctgcacg tcgcacttca
    27961 aaagcgaaga aaaacaaacg tcgtacacac tacaaagtaa cagctccatc tgtaaacttt
    28021 gacgaaacta ctggagatta ctcacgttct caccgtgtat cacttaaagg atactacaaa
    28081 ggacgtaaaa tcgctaaagc tgcatcagct gaataataga agggagatac catgcgcgta
    28141 aatattacac ttgaacacaa agaatctggt gaacgcttgt accttacttc taaaaacaaa
    28201 cgtaacactc cagaccgcct tcaattgaag aaatactcac caaaacttcg caaacacgtt
    28261 gtgtttacag aagtgaagta agcattcaat acgaatcaat acagaagaaa aacgcttgat
    28321 cagcgttttt tctttttgtt aatttcacta tattgcaagg gaaatcattc gaatgactac
    28381 cttttttgaa ataagaatac ggattcggac aattaaaagc aagaggaact caaatgtaag
    28441 ttggggttcc ttttttgtat atttttcaaa taacgcctct acactatttg tagcaaattc
    28501 accaactaca gttgtatctt agttaaaata agttagaata tgtaagtgag taccagatat
    28561 accaagacat cgtcaccatc taaggtatat tcaaaataca aaagttgacc aactagattt
    28621 ctgaatatcc ttatatatcc attcttaaaa ttggtttaaa tagcgtagtc ttttaaacta
    28681 gttttaagaa tccaaaaaat cttcctacat atgtaagaag attttttagt tcagaatgat
    28741 tagatttagc taatggatac ctatcctacc cactcaccgt tagcattgac tcgatagcca
    28801 tcgggtgtag tcgtgtttac taataaatct cctgaattat aggtatagta ccatttacca
    28861 gaaactgtaa accaaccagt agccattgaa cctgattcgt ttaagtaata ccataagcct
    28921 ttgtctttaa c
//
LOCUS       DAVHSO010000026        26488 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.026, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000026 DAVHSO010000000
VERSION     DAVHSO010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 26488)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26488)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26488
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.026"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            354..1307
                     /locus_tag="VVR18_001106"
     CDS             354..1307
                     /locus_tag="VVR18_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30-like element ISSpn8 family transposase"
                     /protein_id="HEU6032644.1"
                     /translation="MQEHYTPKGKHLTIDNRRLIKRWKNENKSNREIAGLLGKAPQTI
                     HNEVKRGTTLQQVRKGLYKKVYSADYAQTVYQFNRKRSVKKLILTKEIREKILHYHKQ
                     KFSPEMMVNKKQVKVGISTIYYWFHNGHLGLTKADMLYPRKRKGVKKQASPNFKPAGK
                     SIEERPDVINLRLENGHYEIDTVLLTKIKNYCLLVLTDRRSRHQIIRLIPNKTAESVN
                     QALTLLLGEHRILSITADNGSEFKRLSEVFPEEHIYYAHAYSSWERGSNENHNRLIRG
                     WLPKGTKKTTPKEVAFIENWINNYPKKCLDYKSPSEFLLGG"
     gene            1628..1762
                     /locus_tag="VVR18_001107"
                     /pseudo
     CDS             1628..1762
                     /locus_tag="VVR18_001107"
                     /inference="COORDINATES: protein motif:HMM:NF012870.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(2000..3261)
                     /locus_tag="VVR18_001108"
                     /pseudo
     CDS             complement(2000..3261)
                     /locus_tag="VVR18_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886556.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(3268..3729)
                     /locus_tag="VVR18_001109"
                     /pseudo
     CDS             complement(3268..3729)
                     /locus_tag="VVR18_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003093536.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
     gene            complement(3732..4334)
                     /locus_tag="VVR18_001110"
     CDS             complement(3732..4334)
                     /locus_tag="VVR18_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003094863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032645.1"
                     /translation="MSNIKAKINSKIDNLPDGAVFISNDFLELADYETIRKNLNRFVN
                     EGTIQRIVNGVYYKPRFIELIGEYESPSINEVAIAIARKYNWTIAPSGNTALNLLGLS
                     TQVPAQWTYISDGRYVNFIIGNTKLVFKRTTNSTISNMSQLTALVIQAIKAIGKDNIS
                     EEQILYLKNRLTISDKEKLLEEGKATSAWIYKVLKKIGES"
     gene            complement(4402..7203)
                     /locus_tag="VVR18_001111"
     CDS             complement(4402..7203)
                     /locus_tag="VVR18_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000656693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEU6032646.1"
                     /translation="MKEDKKLVKQARQNFRSNLKSARMHYRKEVRTLKQTVPKKGRFR
                     KPAQNSLFQDKKTELKQNLLGSQKEAEEKFLKEITYVSPRLLRVKEIKNYRLPQAQER
                     LRTAKKQLSEVKLDEKQKAVNPKFLFQKENPSSKSHFQFHQEKSFDRLSAEKEVRSAK
                     REVKQLKKVRKSKKNSTKVKGGLGLAISESLDLVAQDDDLDGLRTIKDTSLKARRYGR
                     FTYQAGKVAVKSGQTSVRFTKTKVAHGKERFHNFKKGKGFTRQKPLKSRRRYQTFLKH
                     ARKHSLAGIKGIAQAIKGSLTFFSAIAGNPLTWIVSGILLILLLMMSFFMSVSGSSVI
                     QQDEMELTKAYTHMTWEDAEHTRTNEKGITYYTKVDDVMVYMNHQYQDYKLDDVKETG
                     GAIYKAFLSQVWTDLNGGDSIKSMSDLYKEPSYKLSDEDQEELKELTEEGNYLALQEL
                     DNPFQGQTDEDSLNMSYRYGYEVIDEKPTLHHHIILEAKEDQVIVAPMDGKVSLDGEN
                     VILTSGKGVNRTKLTLFGIHSGRVSENQQVLAGDIIGQNKDGTGLKVTYQKVDDDTDK
                     LVYVNPAFYFPKVIQVQTTILPTIGQFGGDEFERAKAIYDYLKSEGATNQAIAAILGN
                     WSVESSINPKRAEGDYLSPPIGATDSSWDDEGWLSLNGPTIYNGRYPNILKRGLGLGQ
                     WTDTADGSRRHTLLLEYAKGKHQKWYDLGLQLDFMLHGDSPYYSNWLKDFFKNSGSPA
                     SLAQLFLIYWEGNSGDKLIERQTRATEWFYQIEKGFSQPNGGTAQSDPKSLEAVRGDL
                     FENSIPRGGDGMGYAYGQCTWGVAARINQLGLKLKGKNGEKIPIISTMGNGQDWVRTA
                     ASLGGETGTIPQAGAILSFAGGGHGTPTEYGHVAFIEKVYPDGSFLISETNYNGNPNY
                     TFRKLSGVDSSLSFAYTTK"
     gene            complement(7205..9530)
                     /locus_tag="VVR18_001112"
                     /pseudo
     CDS             complement(7205..9530)
                     /locus_tag="VVR18_001112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000734154.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
     gene            complement(9487..9840)
                     /locus_tag="VVR18_001113"
     CDS             complement(9487..9840)
                     /locus_tag="VVR18_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrgI family protein"
                     /protein_id="HEU6032647.1"
                     /translation="MNTRVFKDISKVQHRAWLGFTTRQVVFVFPAVAITIMVLGLNLF
                     YWQFGDWFVYGFVFSFTIPLMLFGVYRPNDLPFETYLKYRFHYELTVPDRTFTGRKGD
                     QREKIKPLNETKDLF"
     gene            complement(9902..10756)
                     /locus_tag="VVR18_001114"
     CDS             complement(9902..10756)
                     /locus_tag="VVR18_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003065166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TrbL"
                     /protein_id="HEU6032648.1"
                     /translation="MMMNFTSPFVFLASEKVSSDSLFEGFQVDLETTANLVKSLADFN
                     PTVWSYMTAITKGIMQPLGVAILAVVLVLEFSKMAKKIANSGGAMTFEAIAPMIVSYI
                     MVAVVITNTTVIVEAIIALASYVIEQVAGLVTNGGASYDTISGIKGSGIVGKMIIGFF
                     AILIWLVRMVSIMVVNILITIRFIQLYLMIPFAPVTIPTFLSDDWRSVGIGYLKNIMV
                     YAVQGILIFLIVSLVPLFESAGKIAVSNGAGVMESLAIMFGGLVQAILLIIALVGSQR
                     TARSILGM"
     gene            complement(10775..11017)
                     /locus_tag="VVR18_001115"
     CDS             complement(10775..11017)
                     /locus_tag="VVR18_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012678629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032649.1"
                     /translation="MNQKLTGFVYGVDASPMFSQAMSLLQKGLIAVGAFLVVMGIINL
                     STNIKDGGPGVRNAILEIVGGVMVGAAGAFVTQITI"
     gene            complement(11035..12816)
                     /locus_tag="VVR18_001116"
     CDS             complement(11035..12816)
                     /locus_tag="VVR18_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretory system conjugative DNA
                     transfer family protein"
                     /protein_id="HEU6032650.1"
                     /translation="MGLAFGYFCHRLTLLYDSLTNAPPMERFAYLLGEGLNQVFNPLW
                     LFSFTRKSLLAFILGVITMSLVYLYVSTGQKVYREGEEYGSARFGTSKEKRFFYSKNP
                     FNDTILTRDVRLTLLEKKKPQFDRNKNLIVIGGSGAGKTFRFVKPNLIQLNCSNIVVD
                     PKDHLAEKTGKLFLENGYQVKVLDLVNMTNSDGFNPFRYVETENDLNRMLTVYFNNTK
                     GNGSRSDPFWDEASMTLVRAIASYLVDFYNPPGSSKQEQEARRKRGRYPAFSEIGKLI
                     KLLSKGDNQDKSVLEVLFEDYAKKYGHENFTMRNWADFQNYKDKTLDSVIAVTTAKFA
                     LFNIQSVIDLTQRDTMDLKTWGTQKTMVYLVIPDNDTTFRFLSALFFSTVFSTLTRQA
                     DVDFKGQLPIHVRSYLDEFANVGEIPDFAEQTSTVRSRNMSLVPILQNIAQLQGLYKE
                     KEAWKTILGNCDSLLYLGGNDEETFKFMSGLLGKQTIDVRSTSRSFGQTGSSSTSHQK
                     IARDLMTADEVGNMKRDECLVRIAGVLVFRTKKYFPLKHKNWKWLADKESDERWWHYH
                     INPLITEEEIDLSGHTIRDLSTEMSIY"
     gene            complement(12852..13340)
                     /locus_tag="VVR18_001117"
     CDS             complement(12852..13340)
                     /locus_tag="VVR18_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032651.1"
                     /translation="MSSEQQERQAMQYVERSSLFTVRTLLKLLEWSARQALAQDSAYK
                     IGVQKLEELLQSPYAIEAIDVSKDILDKPIDVEKFKELMESEKLPIAISWQKDYLYFY
                     AKDKTLLDHHLDELLKKLMSNPEKLEGLTFDKSLDQEIELAKEKIKVTEPSVVRTKEV
                     TL"
     gene            complement(13417..14001)
                     /locus_tag="VVR18_001118"
     CDS             complement(13417..14001)
                     /locus_tag="VVR18_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6032652.1"
                     /translation="MIRIVLFYLAIQLNGLLVSLYLHDYMTIKVLILLQTLLLGVACL
                     EITHHKTVQAKNITLQNRLRWLLLGFACMVSFAVLISFLFPVQTRNQSVLVEVGKQVP
                     HVIFLLFLVNASVLEEIVYRQLLWEKLTFPFVQIGVTSFLFSLAHGSNQLGSWLMYSC
                     LGVTLAVVRLKTDCMTAMTLHLLWNSLVYVLTFL"
     gene            complement(14004..14237)
                     /locus_tag="VVR18_001119"
     CDS             complement(14004..14237)
                     /locus_tag="VVR18_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003065178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEU6032653.1"
                     /translation="MNERFWDNLEIILAEKELTWAELARKVFKGQYVYPSEFNRLYQK
                     LRHYKSNRLMPQTRWVERIVLVLDIDYEDLFKR"
     gene            complement(14246..14629)
                     /locus_tag="VVR18_001120"
     CDS             complement(14246..14629)
                     /locus_tag="VVR18_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017770591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032654.1"
                     /translation="MLEVYLGNNDNTNRDLLTILTTYGVTYRCTKACDVNREIILSLF
                     AKTMDCFELLSPRFLRFKRQYTISLNEMIQLILQKPDQNLRLPLIVCQNHVYPAIGLD
                     EVRTFLPRQVKEELFQASLMTQVTG"
     gene            complement(14640..15068)
                     /locus_tag="VVR18_001121"
     CDS             complement(14640..15068)
                     /locus_tag="VVR18_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032655.1"
                     /translation="MNLLHKKSILECTELEERIHQVEINQLLQKILSLPNFDCDFEVT
                     FEDDYHKEMNDPLFYESNLHRISDFLETRDIKNGVDTLLTKDNHLAFRAFGQNYTARG
                     KDGILTTLVTVKCSGEGRMPVDMSHYFSTPEPTVENSLTL"
     gene            complement(15052..16407)
                     /gene="dcm"
                     /locus_tag="VVR18_001122"
     CDS             complement(15052..16407)
                     /gene="dcm"
                     /locus_tag="VVR18_001122"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000670032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HEU6032656.1"
                     /translation="MKFLDLFAGIGGFRLGMEAQGHECLGFCEIDKFARTSYKAMFKT
                     EEEIEYHDIKEVTDHDIRQFRGQVDVICGGFPCQAFSLAGRRLGFEDTRGTLFFEIVR
                     CAKQIQPRFLFLENVKGLLNHDEGRTFATILSTLDELGYDVEWQVLNSKDFQVPQNRE
                     RVFIIGHSRRYRSRFLFPLRRENSPAHLERLGNINPSKRGLNGEVYLTTGLAPTLTRG
                     KGEGAKIAIPVLTPDRLEKRQHGRRFKDNQDPMFTLTSQDRHGVVVAGNLPTSFDQTG
                     RVFDIAGLSPTLTTMQGGDKVPKILLREELPFLKIKEATKRGYAKATLGDSVNLAYPD
                     STKRRGRVGKGISNTLTTSDNMGVVVAAMEYRQDKWYEVTGIVLDGKLYRLRIRRLTP
                     RECFRLQGFPDWAYERAESVSSKSQLYKQAGNSVTVTVIEAIAREFRRMEEEEKHEPT
                     T"
     gene            complement(16565..17374)
                     /locus_tag="VVR18_001123"
     CDS             complement(16565..17374)
                     /locus_tag="VVR18_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="HEU6032657.1"
                     /translation="MKRITANQYQTSERYYKLPKILFESERYKDMKLEVKVAYAVLKD
                     RLELSLSKGWIDEDGAIYLIYSNSNLMALLGCSKSKLLSIKKTLREYGLIDEVQQSSS
                     EKGRMANKIYLGELEHESIPVLDSDGASVKKTLGGAQKKTGPVLNSAPSETEGNETEY
                     SETEGSDFLIEDEEERQLVDDKQEENFSSKVDAVTKYDRDYIWDLVHDQLRQTGLSQS
                     ASDYAMIYFSERYQYALEHMRFARSAEVIAEYVFNGVLSEWTKQLRRQEVR"
     gene            complement(17371..17544)
                     /locus_tag="VVR18_001124"
     CDS             complement(17371..17544)
                     /locus_tag="VVR18_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032658.1"
                     /translation="MQKYEQSSRQLVMCQLMAIMGVDIVKATQLIDEMEQVGLIQFDE
                     FGNVGILVLEGQS"
     gene            complement(17622..19556)
                     /locus_tag="VVR18_001125"
     CDS             complement(17622..19556)
                     /locus_tag="VVR18_001125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000794686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HEU6032659.1"
                     /translation="MKKEVKVIKGDTTLKRTASGCVERSIKRVAAYCRVSTDTEDQIN
                     SYNSQVEHYTEFIQKNNEWTLAGIYADEAITGTQVDRRIDFQRLINDCMNGDIDMIIT
                     KSISRFARNTLDTLKYVRKLKEFNVAVFFEEENINTLTMDGELLLTILSSVAQQEVEN
                     ISANVKKGLRMKMERGEMVGFQGCLGYDYDPETKSISINEKEAEIVRYIFRRYIEGVG
                     GMVISRELEEQGYLSPRGNKRWTETTVLGIIKNEKYKGDLMMGKTYTVDPISKRRLDN
                     FGEQDKFYIENHHEPIISEEDFEKAQGIRLRRSKNRNTVANNGGKREKYSRKYAFSSM
                     LECGFCGHNLSRRNWHSSSEYTKVIWQCVNATKNGKKYCPHSKGIEEEAIEKAFMESY
                     RQVCHNNVEITNEFLKTVEEELKDNSLAKDLKKITNQLDRILKKEKDLVELRLNESIS
                     MDIYQDKYNEIAISKEKLLAEKRTLEVTLTDEKALKKRLEGFKKLLESNKYLEEFDRA
                     VFESIVDKIIIGGTNDEGEIDPAMITIIYKTGKKDSQDGRLFKSRRKNAKEVNEKADS
                     KLYPQSSDEVNNLCSYPMDNTRGVRSIATTKKRVKILYFKHFFKHFVFIEKSDFDIKK
                     VQKKYIDVNVCLDVDCVDKK"
     gene            complement(20221..20631)
                     /locus_tag="VVR18_001126"
     CDS             complement(20221..20631)
                     /locus_tag="VVR18_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004634151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU6032660.1"
                     /translation="MPKEYYLYVNGQRVKVSEQIYKVYWREREHEKYLEQVDRKNHLL
                     FFSSLDHDGHFVDNIVDESVDVEKIVETQMMIEAVRNAISRLNAEERDIIERLYFNDE
                     TVRSVAKLKSITHPALIKRRNKILEKLKKFIEEL"
     gene            complement(20975..22333)
                     /locus_tag="VVR18_001127"
     CDS             complement(20975..22333)
                     /locus_tag="VVR18_001127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEU6032661.1"
                     /translation="MGKQDMKTQLLTKSPKDLLFQLAIPGIIGMVVIGLYPFMDGIFA
                     GWIIGDYAMSAISISMSLTIINGGISALIGVGSASILSRAIGKGDKETTDKIFGNFCY
                     WVILFSIVITVLGLVFAPNFLDLVGAKGNIKELGVRYLRVVFFGSIFVNFAQAGNMTM
                     RGEGALKQSMMIMGVGALLNIILDPIFMKLMGEYAIEGAAIATVISQIVQAILTFHYF
                     SKKSAFVGIHKIQKSKAIYSEMFSIGSSAMMMQILFAVQQTFLFKQAFAYGGDNWGIL
                     MSATMRLYMFSFIPLWGMSQGLQPVIGANFGAKQYQRVKDTMKIFMYGATILAAISWI
                     PSMFFSEKLLSLFNVRSEIIEAGVMNFKLFYSTFILYGIMIMTLTFFQSIGDGKKASM
                     IVMLRQLILFIPAILLLPKVFGGLAVWWAEPIVDFSMILLGLFLMLSRLRKIGKEEAI
                     NC"
     gene            complement(22369..24102)
                     /locus_tag="VVR18_001128"
     CDS             complement(22369..24102)
                     /locus_tag="VVR18_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006269672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032662.1"
                     /translation="MLSALKKILDFSGDEKKNIYHSIWVSFLFAIFHMLQISAIYFIV
                     KAVSEKDMSMTPAWIALILLVVSIVGRSIANYYSQLQQCHASYFMVANKRISIGEMFK
                     KIPMGFFNGNNGGEVVGISTTVLEDVENTAAMVMVNTLSGFINTIIFTLMILIFEWRI
                     GFIVTVGSLLYLVILSKMEKKSREVLPKRQMASAKLVDTVLEQIGGMSVIKSFNLTGK
                     GDEKVRGAIENTRKTNLDCEKLFTPYTIVQNILLDLFSILIIGAGIFFYQRGELSFLN
                     TVMTIIISFLAFSQIKLAGSATTALRVVSGSIEQTKKLEEFPQMDIEGKDIKPANFNI
                     SFENVEFAYSGKKILDDISVDIPQNQMTAIVGPSGAGKTTFCNLIARFWDIDNGKISI
                     GGHNIKEYSLESLMKQISMVFQNVYLFQDTIENNIKFAKPNATHEEVVDAAKKACCHD
                     FIMNLPEQYQTVIGEGGASLSGGEKQRISIARAMIKNAPIIIFDEATANVDPENEDKL
                     QLAMEELTRNKTVIMIAHRLKTIKNANQILVLANGKIMQKGTHEELIQTDGIYRNFVE
                     ARQVATKWQLS"
     gene            complement(24096..25841)
                     /locus_tag="VVR18_001129"
     CDS             complement(24096..25841)
                     /locus_tag="VVR18_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003033264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032663.1"
                     /translation="MKEKSPTAILWELAHDEHPKLKTSVFIASIGVLAGIVPYIAASR
                     ILVYLVNGIEDSKVYLMWLGIGLLSYALKSILYSLALSVSHKATFSVLKDIRLRMLDK
                     LPKMPLGEIINIPSGNLKQIIVDQVESMEKPLAHLLPEMTSNILGSLSIFIYLLFLDW
                     RMALLSLVSIPLGMFFMGLVMKNYAAQYEGSVKVSREMNSAIVEYVNGIEVIKTFNQD
                     KRSYAKYKDKVIANAKYFYEWMRSCQLPVSLSKNISPTTMITILPVGWYFYINGSLSI
                     ETFIVVIILSLGIAGPLLETMNFVDGLAKIGTIANSINSILEGKEQIHSNVDVKINKY
                     DIALQDVKFGYEEGKEILHGVSLNIEEGTTIAFVGPSGSGKSTLAKLIAGYWDINTGS
                     IKIGGYNLQEIPLKQLYSLVAFVSQDNFLFNESIRENIRMGNPSASDKEVENIAKKSG
                     CHDFIMNMEKGYDTVVGSSGSHISGGERQRISIARAMLKKSPIVILDEATSYIDPENE
                     VIIKEALSKLIQNKTVIVIAHRLSTITDVQQIFFVENGELISHGKHNELMEDCELYKK
                     MWNAHIGVKDGEIKC"
     gene            complement(25875..>26488)
                     /locus_tag="VVR18_001130"
     CDS             complement(25875..>26488)
                     /locus_tag="VVR18_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002844950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6032664.1"
                     /translation="KNTPSNFVNESITCLHFKKTYDKNTIFDFSVSFNTGINFIIGQN
                     GVGKSTFINLLMGTIKGKGEVFYKGEKLKKRYENIFAVMQDVNYQLFTESVWQEIGTV
                     TKQDNLKNEALRKVHLFNKKEMHPSSLSGGEKQRLLLAMSMVSQKPIIVFDEPTSGLC
                     KMQMDILIGFLNQMVEQGKTIIIITHDFEFIKQCDGAIYEFLK"
BASE COUNT         7808 a         5617 c         4338 g         8725 t
ORIGIN      
        1 gaacaagtct agtataattt taccacaaag taacatgatt tgcaagcgat ttcaataata
       61 aagatatatg attatcctca ggaataaata aatttgaaag ttctataatg aagttagcca
      121 ccttacctta gtcaagaatt agatgtttca ctatgtttga gtaagttgat gatttcattt
      181 gataacaggt ttgaaactgt taggctaggt ggccaaggct aatcatagcc ttggtttagc
      241 tgaaaaaaca ggttcaaggg ttcctgttgt caaatgaaat gtgatttaag gtataagaaa
      301 acacctctgt gctatacttg ttgttcacca caaacacaag gaaaggcaca gagatgcaag
      361 aacattatac cccaaaaggg aaacatttga caatagataa ccgtcgcttg attaagcggt
      421 ggaagaatga aaataagtcc aatcgtgaaa ttgcaggctt gttaggaaag gcgcctcaaa
      481 cgattcataa tgaagtcaaa agaggtacaa ctttacaaca agtgagaaaa gggctataca
      541 aaaaggtcta ttctgccgat tacgcacaaa ctgtttacca attcaatcga aaacggtcgg
      601 tgaaaaagtt aattttaaca aaggaaatca gagagaagat cttacactat cataagcaaa
      661 aattttcgcc tgaaatgatg gttaacaaga agcaagtgaa agttggtatt tcaaccatct
      721 actactggtt tcataatggt catttaggat tgacgaaggc cgacatgctt tatcccagaa
      781 aaaggaaagg tgtcaagaag caagctagtc cgaactttaa gccggcaggt aaatctatcg
      841 aagaacgtcc tgacgttatt aatcttcgct tggaaaatgg tcattatgaa attgataccg
      901 tcctactgac taagataaaa aattattgcc tgttagtctt aaccgaccgg cggagcagac
      961 accaaattat aaggttaatt ccaaataaaa ctgctgaatc tgtcaatcag gcgcttacgt
     1021 tactattagg ggagcatcgt attctgtcca ttactgcaga taatggttcg gagttcaaac
     1081 gattgtctga ggtatttcct gaggaacata tctactacgc acatgcttac tcttcatggg
     1141 agagaggttc aaatgaaaat cataatcgat taattcgggg atggttacct aaaggaacca
     1201 agaaaacgac tccgaaagaa gtagctttta tcgaaaattg gattaacaac taccctaaaa
     1261 aatgcttgga ctacaagtcg ccaagtgaat ttcttttggg tggctaactt caacttgaaa
     1321 tttgggcttt gtctctatgc taaaggaatc cgctataaat acaagtacta tagccgtcgg
     1381 cattcctcat taacacgacc caatttgatt aatcagtgtt ttcaaacaaa aggtaaaaat
     1441 gaaatctggc tgggggattt aacttatatt ccgacaaaag caggtactct ttatttatca
     1501 ttatatatat gtttatagca gaaaaattgt tggttaggca atgggaaatc gaatgcaaga
     1561 taagttggta acgaatgttt tcaatcaagc ttatcataga gaaaatctca aataagaact
     1621 agtcggccat accgatcaag gatctcaata tactggagct agatttcaag aactccttaa
     1681 acagaaaaga tgcaagtcta gcctgagtcg aaaaggcaat ccatatgata atgcacccat
     1741 ggaatccttt tacaaaacat aaaaagagaa cttgtcaatg atgccaattt cgcaactatt
     1801 gaacgaaatc tttaaatata ttgaaatcta ttacaatcct aaatatctcc attcggcatt
     1861 agggtaccaa taactaatag agtttgaaaa aaatagtcac taatcatcga gtccactgaa
     1921 aaagtaagct ctacagttca actaaaatga aaaaagaggg atctatctcc tgcttggata
     1981 gattcctctt tgcttttcct tatttttggt ttattagagt tataatcctc ttcatattaa
     2041 ccacaaatat ggttgtggcg gcttgtaact ccatgtttaa aagacctggt gctctagcta
     2101 cattaagacc atgtctgttt tcaagttccg catttttggc ttctatcttg tagcgatgtt
     2161 tggccttttc tttaaaatag ggcgcttcct gaaacctctt ctggaaaata tgttcatcgc
     2221 tcttaagggg tatcaaataa gtcttagact tagccccttc tttataacag cccacttttg
     2281 aagggcatat ttgacagtgc ttgatgtcaa aatagtgggt ttcctgagcc gtccttcttc
     2341 ctgtctttgc cttctttagt gccatatgcc cttctggaca aacaaagaga cctgcgtcct
     2401 tgttatagaa aaactcatct tccttcctac gaaagccttt tgaaatagtt ggatatggcc
     2461 tagcgactca atgcacacgt tctttcttgg taaattgcat attatccttc ccagagtagg
     2521 ccctatctcc aacaatagct tcaatcgtca cgccattatc cttagatttg tgatagagtt
     2581 cttctaaaac aggaccatca cttttttcac ccgatgtcac cacacaggca gtaataatcc
     2641 gttcatcggt catggcaaaa tgctctttgt acccgtaaaa ggaactatcg gctgacttat
     2701 gtccaattct tgcttcttct ttgacagagg attccaagtg ctctaagtca tcctctacag
     2761 cttctttaag gtaattgaat tttgtgagat agctggtatt ccagtcaatt cgtcatgctt
     2821 ctcaaggact gatattaatt cttgtgtata tcttaattca gctactagag tatcttcctg
     2881 aggcttacta ggaaattctg ccttgatata ttccgaatac tgataaatcg ttttacgcaa
     2941 ggcttttgag cgttctcgga ggacttcttg aggtttcttg tgattgtaat gaactttggt
     3001 atgagtcgca tccacaatga gaatgttact tttaatcaga ccgagctcta tcgcaatctg
     3061 aacagattta gcgatgagca aatcaagtaa tcgttcatct ttgttccgaa gttttcggaa
     3121 tttagtcaat gaggacggtt caataacagg agctagacca aggaagtatt tgaaggtcat
     3181 accagaaaag gagcgctcca ccacatccac atcggacaac ttatagatgt cttttaataa
     3241 gagatacttg aacatcatga taaggagaga ggttggatat tcaaaaagta ctgtttgtgg
     3301 gtcattttca tcaacactaa tttgaaaatc atcttcaatt aaattcgcaa aatctatcct
     3361 catctgcgga attaatgcat tcacaagaaa gtcttctgct tttaaatttg attccttatt
     3421 gaacttatct tgttgcgtat tagaacgaga ttgccatggt tcgtctttac catatccaat
     3481 tacctgccaa tccaagatta aatcaatatc ttctgaaaat cgcttaatta aatcatagca
     3541 cttagaaaga cttgtgcccc ctttaaatgt aaatgcatcc ttccattcac tctttgtaaa
     3601 gagatagttg agtacaaaac aaacccaata gtctttctca acaatcactt cattgatacc
     3661 aagtctttcc gaagcatttc taataatggc ttgaaggtct tctttggaaa tttttttaaa
     3721 ttctagcatc tttaggattc tcctattttt ttcaagactt tataaatcca ggcactggta
     3781 gccttgcctt cctcaagaag tttttcttta tcacttatag ttaacctatt cttaagatat
     3841 aaaatctgtt cttctgaaat attatctttt ccaatagctt tgatggcttg aataactagc
     3901 gcagttaatt gcgacatatt tgaaatggta ctatttgttg ttcgcttgaa cacaagtttc
     3961 gtatttccaa ttataaaatt tacataccgt ccatcagaaa tataagtcca ttgagctgga
     4021 acttgtgtcg acaaccctaa taaatttaga gctgtgttac ctgaaggtgc aattgtccaa
     4081 ttatattttc tagcaatggc aatagccact tcatttattg aaggagactc atattctcca
     4141 atcaactcaa taaaccttgg tttgtaatat acaccgttta caattcgttg aatcgttcct
     4201 tcgttaacaa atcgattcaa gttttttcta atggtctcat aatcagcaag ctctagaaaa
     4261 tcatttgaaa taaagactgc gccatctggt agattatcaa tcttactatt tattttagct
     4321 tttatgttac tcaattcctc accaccttgt cccaaatatt atacaacatt tgggacaaaa
     4381 tgacaactat ctttctgtct attatttcgt cgtatacgca aaactcaagc tgctatccac
     4441 tccagataat ttacggaagg tatagttggg attgccattg taattggttt cggagataag
     4501 gaatgagcca tctgggtaaa ctttctcgat aaaagccaca tgtccgtatt ctgtcggtgt
     4561 gccatgtcct cctcccgcaa aagagagaat agctcctgct tgtggaattg tgcctgtttc
     4621 accaccaagg cttgcggctg tacgcaccca atcctggcca ttacccatgg tactgataat
     4681 cggaatcttc tcaccatttt tacctttgag ttttaaaccc agttggttga tacgggctgc
     4741 gactccccaa gtacattggc cgtaagcata acccataccg tcaccacctc ttggaataga
     4801 gttctcaaag aggtctccac gtacagcttc aagagatttt ggatcgcttt gtgccgtccc
     4861 accatttggc tggctaaagc ctttttcaat ttgatagaac cactcggtcg ctcttgtttg
     4921 tcgctctatg agtttatctc ctgaattgcc ttcccagtaa atcagaaaga gttgggcaag
     4981 actggctgga ctacctgaat ttttgaagaa gtcctttaac caattggaat aataaggact
     5041 atccccatgc aacatgaagt ccagttgtaa ccccaaatca taccactttt gatgttttcc
     5101 tttggcatat tccagcaaca aggtatgtct gcgtgaccca tctgcggtat ccgtccattg
     5161 tcctaagccc aaaccacgtt tgagaatatt tgggtaacgt ccattgtata tagttggacc
     5221 attaagtgag agccatccct catcatccca cgagctgtct gtcgcaccaa tagggggaga
     5281 tagatagtcg ccctccgcac gttttggatt aattgaggat tctaccgacc aatttcctaa
     5341 gatagctgcg atagcttgat tggtcgcacc ctcacttttg agatagtcat aaatcgcctt
     5401 ggctctctca aactcatcac caccaaactg accgatagtt ggaagaatgg tggtctgaac
     5461 ctggatcact tttggaaagt agaaagctgg attaacatag accaacttat ccgtgtcatc
     5521 atcaaccttc tgataggtga cttttaggcc cgttccatcc ttgttttgac caataatgtc
     5581 tcctgccaag acttgttgat tttcacttac tctacctgaa tgaatgccaa acaaggttag
     5641 tttagtccta ttcactccct taccagatgt cagaataacg ttctctccat caagagatac
     5701 cttaccatcc atcggagcca caatgacttg gtcttctttt gcttctaaga taatatggtg
     5761 atgaagtgtt ggtttctcat caatgacctc ataaccatat cggtaggaca tgtttaagct
     5821 atcctcatcc gtctgtccct gaaagggatt gtccaattct tgaagggcta aatagttgcc
     5881 ttcttcggtc aactccttta gttcttcctg gtcctcatca gacagcttgt agctaggttc
     5941 tttatacagg tcagacatgg atttaataga atcaccacca tttaagtctg tccacacttg
     6001 actgagaaat gctttgtaaa tcgcaccacc tgtttcctta acatcatcta acttgtaatc
     6061 ttgatattga tgattcatat agaccataac gtcatcaacc ttggtgtaat aggtaatccc
     6121 tttttcgttg gttcttgtat gctccgcatc ttcccacgtc atgtgggtat aggccttggt
     6181 caactccatc tcatcttgtt gaatgacact gcttcctgaa acactcatga aaaagctcat
     6241 catcaaaagg agtatcaaga gaatgcctga gacaatccaa gtcaaaggat ttcccgcaat
     6301 tgcagaaaag aaggtcagac ttcctttaat ggcttgggca atccccttaa ttcctgctag
     6361 actgtgcttt ctggcatgct ttaaaaaggt ttggtagcgt cttcttgatt taagcggttt
     6421 ctggcgtgtg aatccttttc cctttttgaa gttgtggaat cgttcctttc catgagcgac
     6481 tttggtcttt gtaaaacgca cactagtctg tccacttttc accgccactt taccagcttg
     6541 ataggtaaat ctgccatagc gtctggcttt caaactagta tcctttatgg ttcttagacc
     6601 atctagatca tcatcctgtg ctaccaggtc aagcgattca gatatagcta agcctaatcc
     6661 acctttaacc ttggtagagt ttttcttaga ctttcggact ttcttgagtt gtttgacctc
     6721 acgtttggca gacctcactt ctttttcagc acttagtcga tcaaatgatt tttcttggtg
     6781 aaattgaaaa tgagacttcg aggaagggtt ttctttttgg aagagaaact tgggattgac
     6841 cgccttttgt ttctcatcta gcttcacttc tgacaattgt ttttttgccg tccgcaaacg
     6901 ctcttgggct tggggaagtc gataattctt aatttccttt acccttaaca gtctaggaga
     6961 cacataggta atttccttta gaaacttctc ttctgcttcc ttttggctac ctagcaaatt
     7021 ttgttttaac tctgttttct tatcttgaaa cagagaattt tgggctggtt ttcgaaatcg
     7081 tcctttttta ggaacagtct gttttaaggt cctaacttct ttccgataat gcatacgagc
     7141 tgattttaag ttgcttcgaa agttttgcct agcttgtttg actagctttt tatcctcttt
     7201 catctcatgt cctcattttt tcagggtctg tactcatgat gtcaaagagc ttggtgtgtt
     7261 gtggaatctt attcttaaac gggacaacgg tggaaccggc cttgattagg ccagcacctt
     7321 tttcaggatt gaccaagtat ttctctagtt ccttggaaag tccaagcaaa tgcaccaact
     7381 cttcgcgatc gctcttagcc tgttttaata gaatcatgaa ctcgctattg gcaataatac
     7441 gtctgccatt ggcatccaaa agaagtgtct ccacattctg agtaatgcca gttggtatcg
     7501 ccccatactt acggacacga ctccagagtt taaagaagaa atcagaggca tatttgtcca
     7561 ataagagaag ctgcatttca tcaaagtaaa tccaggtctt cttccctagt ttttggtttt
     7621 tcaccacacg attccaaatc tggtcaaaga taaccatgag ggcaatttgt tttaattcat
     7681 cgcctagctt tttgacattg taaatcagaa aatgactatc tgtcttgata ttggtccgat
     7741 gcgagaaaat atctagcgat ccttccacat agagttccat atacagtgcc aagttcttag
     7801 cttcctgttc aggttgttga gataagacaa agacccattc gaccaaagat ggtgtatcaa
     7861 aatgcttata ggtaagtcgt gtcacacggt caatcagcga cttttcgcga ccatccattt
     7921 tgcggtccaa gagctttcca atccaagaca agaggaattc ggatttaacc ttgactggat
     7981 cctcatccat attctcatcg gatagttcta aaacatttaa gaaggtagtg gaatctggtg
     8041 caatatcaat actttctcca ccaaaggctt gaccgataat gctgtactca ttttctgggt
     8101 caacaataat aatttcggta tcgctatctg cttccttgag cttagtagag atgatttcat
     8161 gttttgtcgc catccctttt ccagctccag aagtccctaa aatcaaacct gacggagtat
     8221 ttaacttgcc acggtcaata ctgatgatat tacttgagat ttgattgatg ccataaaatt
     8281 tcccaccctt gtcctgaata tcaacggaag tccaaggtgc attcacggca atgtttgaag
     8341 tcaatagaga acgagaaact ccttcgagat agttcttccc aaatggcaag agactattaa
     8401 aagcagcttc ttgcatgtag gtcaagttgt caataatcat atcatttgac cccgccactt
     8461 gcttgataat atcaagggct tgtttgagtt ggtcttcagt atccgccagc acgccaatta
     8521 gaaatacggt gtcaaacagt ttatctcctg tttgggtcat ggtttgaaga agagcttctg
     8581 cttcatcgat attgttttca agaacatggc cgaccttctc caaatagatg ccagtccgag
     8641 ccatcttttg ttgttcccca atcttttgcg attccatcaa ggttttcttg gttcgtaact
     8701 tagtcatagc ttcagactta gttgagcctt tggcgtgtag gctaatcatc acttccaaat
     8761 ctatccccta gctccatacc gtaatcacga acatagacaa tctgtaataa tctatcgtcc
     8821 aattcaatat gattcttgtg tttaaaggaa aggtaggttg gcgcaataaa gtgtttggtg
     8881 gattgacctg acagggttaa atccttgtaa gagaatggta aatgattttc acctcgtaac
     8941 atatccgcaa ggacattcac tcgctcctct ccatcaagta aaccaagaga tacatcaatc
     9001 tctgaaaagc cactcttgaa atattcccca atctgtgaca gggaacgaaa agctagtttt
     9061 ggtgtttggt cgctcttgcc aaatgaaagc aacttgacag ctgaaaagtt attctcaccc
     9121 gcttctaagt tggcatccat catgcgattc aattcatcac ggtagccatc aaacccatct
     9181 tcctgtaagg gatagagaat actcttacga aatttttcca gattgacttt ttgattgaaa
     9241 atagtcagtt ggaaattggt cttatcgtcc agtgaattga ttaaatcaga atatttctcc
     9301 acaatagctc ccttatcgtc taagccaact gtttggtaat tgacatctcc taagagatag
     9361 gtttgtgaaa aatggcttgg gctgacctgc atgagtccat tttgaaagag accttgatag
     9421 gctaacgtat ttagggtaga aggtctgatc tcctgcttct gtgttttcgt cttttgctta
     9481 ttgtcattag aagaggtctt ttgtttcatt aagtggttta attttttcac gttggtctcc
     9541 ttttcttcca gtaaatgtgc ggtctggcac cgttagttca taatgaaaac gatacttgag
     9601 ataggtttca aatggtaaat cattgggtcg atagacccca aataacatga gtggaatggt
     9661 aaagctaaaa acaaaaccat agacaaacca atccccaaat tgccagtaaa ataggttcaa
     9721 gcccaatacc ataatagtta ttgcaacggc tggaaataca aaaacaacct gtcttgtggt
     9781 aaatcccaac catgcacggt gttgaacctt agaaatgtcc ttaaagacac gagtgttcat
     9841 aaatgttctc caatctagat aagctataaa aagaggaggc gggcaattta ctcccatcct
     9901 cctacatccc caaaatactt cgggcggttc gttgactgcc aactaaggca atgattaaca
     9961 agatggcctg taccaaacca ccaaacataa tggcgagtga ttccatgact ccagctccat
    10021 ttgatacggc aatctttcca gcagattcaa acaagggaac aagagataca atcagaaaaa
    10081 tcaaaattcc ttgtacggca tagaccataa tgtttttgag gtagccaatc ccaacacttc
    10141 tccagtcatc actaaggaag gtcggaatgg taacaggggc aaaaggaatc attagataga
    10201 gttggataaa gcgaatggta atcaagatat tgacaaccat gatactaacc attcgcacca
    10261 accaaatgag aatcgcaaaa aagccaataa tcatttttcc tacaattcca gaacccttga
    10321 tgcctgagat agtatcgtaa ctagcaccac catttgtgac aagccctgcc acttgttcaa
    10381 taacataaga ggcaagggca ataatggctt ccacaataac cgtcgtattg gtaatcacga
    10441 ccgcgaccat aatgtagctg acaatcatag gtgctatggc ttcaaaggtc atcgcaccac
    10501 ctgagttggc gattttcttg gccatttttg agaattcgag tacgagaaca accgcaagaa
    10561 tagctactcc caagggctgc ataatcccct tggtaatggc tgtcatgtaa gaccacactg
    10621 tcggattaaa gtccgctagt gacttaacca agttggcagt tgtttctaaa tcaacttgaa
    10681 acccttcaaa aaggctatcg ctagatactt tttcagaggc tagaaataca aaaggtgacg
    10741 taaaattcat catcatgtca tgtgctgtcc tcctctatat ggtaatctgt gtcacaaaag
    10801 caccagcggc acctaccatg acaccaccaa caatttctaa aatggcattt cggacacctg
    10861 gtccaccatc tttaatgttg gttgacaggt tgataatgcc cataacaaca agaaaggccc
    10921 ctactgcaat taagcctttt tgtaatagag acatagcttg ggagaacatg gggctggcgt
    10981 ccactccgta aacaaagcct gttagttttt gattcatatt tttcctcatt tctattaata
    11041 tattgacatt tctgtgctta aatcccttat tgtatggcct gacaaatcta tctcttcctc
    11101 agtgattagg ggattgatgt ggtagtgcca ccagcgttca tcagattcct tatctgcaag
    11161 ccatttccaa ttcttatgtt tgagcggaaa atatttcttg gttcgaaaga caagcactcc
    11221 tgcaattcgt acgaggcatt catctcgttt catattccct acttcatctg ccgtcattaa
    11281 gtcacgggca attttctggt gagaggtgga acttgagccc gtctgaccaa atgaacgact
    11341 ggtacttctg acatcgatag tttgtttgcc tagaagtcca ctcatgaact taaaggtttc
    11401 ctcatcattc ccacccaaat ataagagact gtcgcagttc cctaatatgg ttttccaagc
    11461 ctctttttcc ttatacagtc cttggagttg ggcaatattt tgcaagattg gtactagact
    11521 catattccta gagcgaactg ttgaggtttg ttcagcaaag tctggaattt ctccgacatt
    11581 cgcaaactca tccagatagc ttcgaacatg aatcggcaat tgccctttaa agtccacatc
    11641 agcctgtctg gtcaaagtag agaaaaccgt agagaaaaat aaagcagata ggaaacgaaa
    11701 agtcgtatca ttgtctggaa ttacaagata gaccatggtc ttttgagtgc cccacgtttt
    11761 caaatccata gtgtctcttt gcgtcaaatc aatcactgat tggatattaa aaagggcaaa
    11821 tttagctgtt gtaaccgcaa tcaccgaatc caacgtctta tccttatagt tttggaaatc
    11881 cgcccaattt cgcatggtaa agttttcgtg gccatatttc ttagcatagt cttcaaacaa
    11941 gacttcaagg acacttttgt cctgattgtc tccctttgat aagagtttga tgagtttccc
    12001 aatctcagaa aaggctggat aacggccacg cttacgtctt gcttcctgct cttgcttgga
    12061 acttcctgga ggattgtaaa aatccaccaa ataagaggca atagctcgca ccaaggtcat
    12121 agaagcctca tcccaaaagg gatcactgcg agaaccattt cctttggtat tattaaaata
    12181 gaccgttaac atgcggttca aatcattttc agtttctaca tagcgaaagg gattaaaacc
    12241 atctgaattg gtcatattaa ccaagtctaa aaccttgact tgataaccgt tttctaaaaa
    12301 gagcttgcct gttttttcag ccaaatggtc cttaggatct accacaatat tggaacagtt
    12361 aagttggata aggttaggct tcacaaagcg aaaggtcttt cctgcaccag aacccccaat
    12421 gacaattaga tttttatttc ggtcaaactg gggtttcttc ttttccaaca aggttagacg
    12481 aacatcacga gtcaaaatcg tgtcattgaa aggattctta ctgtaaaaga atcgcttttc
    12541 cttactggtt ccaaagcgtg cagaaccgta ttcttcccct tctcgataga ccttctgtcc
    12601 tgtcgataca taaagataga ctagcgacat cgttataact ccaaggataa aggcaagaag
    12661 ggattttcga gtaaagctaa atagccataa aggattgaaa acctgattta acccctctcc
    12721 taagaggtag gcaaaacgtt ccataggtgg tgcattggtt aaactatcat agagtagggt
    12781 taggcggtga cagaaataac caaaggcaag tcccaagaat ccaaagacta atgcttttca
    12841 tctgaaatac attacaaggt aacctccttg gttctaacta ccgaaggttc tgtcactttt
    12901 attttctctt tggccaattc aatctcttgg tccaagcttt tatcaaaagt tagcccttct
    12961 aacttttctg gattagacat cagtttcttt aataattcat ctaagtgatg gtccagcaag
    13021 gtcttatctt tggcataaaa gtagagatag tctttttgcc aactaatagc aatcggtagt
    13081 ttttctgact ccatcaactc cttgaatttc tccacatcga ttggcttatc cagaatgtct
    13141 ttactgacat caatcgcttc aatggcgtaa gggctttgaa ggagttcttc cagtttttga
    13201 acaccaatct tataagctga atcttgggct aaggcttgcc tagccgacca ttctaagagc
    13261 tttaagaggg ttctaacagt aaataaacta cttctttcca cgtattgcat cgcttgacgt
    13321 tcttgttgtt cagatgacat gatgacttcc tcttctttga attccctatc aaacataagg
    13381 tgcttccata atacagaagc actcttgatt ttggtatcac aaaaaggtca agacataaac
    13441 caaactattc caaagtaaat gtaaggtcat tgccgtcata caatctgttt tcaaacgaac
    13501 aacagccaag gtcaccccaa gacagctata catgagccaa ctccctaact gatttgatcc
    13561 atgggctaaa gaaaagagaa aactggtcac tcctatttgt acaaaaggga atgtcaattt
    13621 ttcccacagc aattgcctat aaacaatctc ttcaaggaca cttgcattga ccagaaacaa
    13681 taaaaagata acatgtggaa cctgctttcc tacttcaact agtaccgatt gattcctagt
    13741 ctgaactgga aaaagaaaac taattaagac tgcaaaagaa accatacacg caaagccaag
    13801 aagcaaccat cttaggcgat tttgtaaggt aatatttttt gcttgaacag ttttgtgatg
    13861 agtaatctct agacaagcta cacctaaaag aagcgtttgt agcaggatta agaccttaat
    13921 cgtcatatag tcatgcaggt ataaactcac aagaagaccg ttaagctgta tggctagata
    13981 aaacaacact atccttatca ttgtcacctc ttgaataaat cttcataatc aatatctaag
    14041 actagaacga ttcgctcaac ccatcttgtc tgtggcatta aacgattgga tttgtaatgc
    14101 cgtaattttt gatagaggcg attaaactca cttggataaa catattgacc tttgaatact
    14161 ttgcgagcta gttctgccca agtgagttct ttttctgcca gaatgatttc taaattgtcc
    14221 caaaatcgtt cattcatctt cacacctacc ctgtcacttg tgtcatcagg ctggcctgaa
    14281 acagctcttc ttttacctgt ctgggaagaa aggttcgcac ttcatctaac ccaatagctg
    14341 gatagacatg attctggcag acaatgagag gcaaacgaag gttttggtct ggcttttgga
    14401 gaatgagctg gatcatctcg tttaaactga tggtgtattg acgcttaaag cgaagaaatc
    14461 gtggcgacag caactcaaaa caatccatgg ttttggcaaa gagtgacagt atgatttcac
    14521 ggtttacatc acatgctttt gtacaacggt aagtcacacc ataggtcgtc aaaatggtta
    14581 gtaagtctcg atttgtattg tcattatttc ctagatatac ctcaagcata ggctcctcct
    14641 tatagggtta ggctattttc aactgttggt tctggagttg agaaatagtg actcatatca
    14701 acgggcatcc gtccttcacc ggagcactta accgtcacca gagtcgttaa aataccatcc
    14761 tttcccctag cagtataatt ttgaccaaag gcacgaaagg ccaagtgatt gtctttcgtc
    14821 aatagtgtat ctactccatt tttaatatcc ctagtttcca aaaaatccga aatccgatga
    14881 agattggatt cgtagaatag gggatcattc atctctttgt ggtaatcatc ttcaaaagtc
    14941 acctcaaagt cacaatcaaa attggggagc gacaatatct tttggagtag ctgattgatt
    15001 tcaacttgat gaatacgttc ctctaattca gtacactcaa ggatactttt cttatgtagt
    15061 aggttcatgt ttttcttcct cttccattct tctaaattct cttgcaatgg cttcaataac
    15121 tgtgacagtc acactattac cagcctgttt gtatagttgg ctcttactag aaacactttc
    15181 tgctctttca taagcccaat caggaaaacc ttgaagtctg aaacactctc ttggtgtcag
    15241 tcgtctaatt ctcaggcgat agagttttcc gtctaagaca atccctgtga cttcatacca
    15301 cttatcctgt cgatattcca tagcagcaac tactactccc atattgtctg aagtcgtcag
    15361 agtattggat attcccttac ccactcgccc tctccgtttg gttgagtctg gatatgccag
    15421 attgacagag tctccaagag ttgcctttgc gtaccctctt tttgtggctt ccttgatttt
    15481 cagaaatggc aactcctctc tcagcaaaat ctttggcacc ttatctccac cctgcatggt
    15541 ggtcaaggtc ggtgacaaac cagctatgtc aaatactcta ccggtctggt caaagctagt
    15601 cggcagattt cctgcgacga caacaccatg tctatcttga ctagtcaaag taaacatagg
    15661 gtcttgatta tccttaaagc gacgcccatg ttggcgtttt tcaagtctat ctggtgttaa
    15721 gactggaatg gcgatttttg ccccctctcc tttacctctc gttagtgtag gagcaagtcc
    15781 agtcgtcaga tagacttcac cattcaaacc acgtttagag ggattgatat ttcctagcct
    15841 ttcaagatga gctgggctgt tttctcttct gagaggaaat aagaatctgg aacggtatct
    15901 tctagaatgt ccgataataa agacccgttc tctgttttgc gggacttgga agtccttact
    15961 gttaagcacc tgccattcga catcataccc caattcatcc agcgtggaga ggattgtggc
    16021 gaacgtccgt ccctcgtcgt gattgagtag gcctttgacg ttttccaaaa atagaaaacg
    16081 tggttggatt tgtttggcgc atctaacaat ttcaaaaaag agagtccctc gagtatcttc
    16141 aaatcccaat cgtcttcctg cgagtgaaaa agcttggcaa ggaaatcccc cgcagataac
    16201 atccacttgc cctctaaatt gtctaatgtc atggtctgtg acctctttaa tgtcatggta
    16261 ttctatttct tcttctgtct taaacatggc tttgtaggaa gttctagcga atttatcaat
    16321 ttcacaaaag cccaagcact catggccctg tgcttccatt cccagcctaa aaccgcctat
    16381 cccagcaaat aaatctaaaa atttcatttt tcctctcttt ccaaataaaa aagagcctta
    16441 cacttgtaaa actcttgcct atatatgatc atccatttct ggtgcacgga tgatttcaac
    16501 gatcaaaatg atgagcgaaa tcagatagat cccacctagt atccaccaaa tcatcttaat
    16561 cacctcacct tacttcttgt cgtctcagtt gcttggtcca ctctgacagc acaccattaa
    16621 acacgtattc agctatcact tccgctgacc gagcaaatct catatgttcc aatgcgtact
    16681 gataacgttc actaaaatag atcatggcat agtcactagc cgactgtgat agacctgtct
    16741 gtcttaactg gtcatgaacc aaatcccaga tatagtctcg atcgtacttt gtcacggcat
    16801 cgacttttga agaaaagttt tcttcttgtt tgtcatctac tagctgcctc tcctcctcgt
    16861 cctcaataag gaaatcactc ccttcagttt cactatattc agtctcattt ccttcagtct
    16921 cactaggggc tgaatttaag actggccccg tctttttttg agccccccct agtgtttttt
    16981 taacactagc cccgtctgaa tctaagactg ggatagattc atgttctaat tcccccaagt
    17041 aaattttatt tgccattcga cctttttcac tagaggactg ttggacttca tcaattaagc
    17101 catattcacg taaggttttc ttgatagaga gtaattttga ctttgaacag cctaaaagtg
    17161 ccatcagatt tgaattggaa taaatcaagt aaattgcccc atcttcatca atccaacctt
    17221 tactcaaaga caactccaaa cgatctttta aaaccgcgta ggctacctta acctccagtt
    17281 tcatatcctt ataccgttca ctctcaaaca aaattttagg gagtttataa taacgctctg
    17341 atgtctgata ttgatttgcg gttatacgtt tcatgattgt ccctccaaga ctaatattcc
    17401 aacatttcca aattcatcaa attggattaa tcctacttgt tccatttcat caatgagctg
    17461 agttgctttt acaatatcaa ctcccatgat agccatgagc tgacacatca cgagttgacg
    17521 tgatgattgt tcatactttt gcatcatttc ctcctgaaaa taaaaaaagc gagaacactt
    17581 ataaaaatgt tctcgctgaa ccaatatatt ttctgacgta tctatttttt gtctacgcag
    17641 tcgacatcca aacaaacgtt cacatcaatg tacttttttt gaaccttttt tatgtcaaaa
    17701 tcactctttt caataaagac aaaatgcttg aaaaagtgct taaaataaag gatttttaca
    17761 cgtttcttcg ttgtagcaat actacgcact ccacgtgtgt tgtccatagg ataggaacac
    17821 aaattattaa cctcgtcgct tgattgagga tacaatttac tgtcagcttt ctcattgact
    17881 tccttagcat tttttcttct gctcttaaat aatctcccgt cctgagaatc ttttttcccg
    17941 gtcttgtata tgatagtaat cattgcagga tcaatttcgc cttcatcgtt agttccacca
    18001 atgatgattt tatccactat actttcaaat acagctctat caaattcctc aagatattta
    18061 ttggattcaa gtaatttttt aaatccctca agccttttct tcaatgcttt ttcatcggta
    18121 agtgttacct ctaaagtcct cttttctgca agtagtttct ctttactaat agctatttca
    18181 ttatacttgt cctgatatat atccatgctg attgactcat tcagtcttaa ctcaacaaga
    18241 tccttttctt tctttagtat cctatcaagt tgatttgtta tcttcttcag gtctttagct
    18301 aaactgttgt ctttcaattc ttcttccaca gttttaagga attcattggt aatttccaca
    18361 ttattatggc atacctgacg atagctttcc ataaatgctt tttctattgc ttcttcttca
    18421 atccctttac tatgtggaca atacttcttt ccgtttttag tggcattgac acactgccat
    18481 ataacttttg tatattctga actcgaatgc caatttcttc ttgaaagatt atgaccgcaa
    18541 aatccacatt caagcatact gctaaaagca tattttcttg aatacttttc tcttttacca
    18601 ccattattgg caacagtatt tctgtttttt gaccttctta atctaatacc ttgagctttt
    18661 tcaaaatctt cttctgaaat gattggctcg tgatggtttt ctatataaaa cttatcctgt
    18721 tctccgaaat tatccaatct tctctttgaa ataggatcaa ccgtataggt ctttcccatc
    18781 ataagatccc ctttatattt ttcgtttttt atgattccta aaacagttgt ttcagtccat
    18841 cttttatttc ctcttggcga taaatatcct tgttcttcca gttctctgga aattaccata
    18901 ccgccaacac cttcaatgta tcttctaaaa atatatctta caatctcagc ttctttttca
    18961 ttgatagaaa tgcttttagt ttccggatca tagtcatagc ctaaacaccc ttgaaagccg
    19021 accatttctc ctctttccat cttcattctc aaaccttttt tgacattggc tgaaatgttc
    19081 tctacttcct gttgagcaac tgaacttaaa attgttaaaa gcaactcacc gtccattgtt
    19141 aaggtgttta tgttttcttc ttcaaaaaaa actgcaacat taaattcttt cagctttctt
    19201 acatacttta aggtatctaa tgtatttctc gcaaatcttg atatagactt tgtaattatc
    19261 atatctatat cgccattcat acagtcattt atcaaccttt gaaagtcaat tcttcgatca
    19321 acctgtgttc ctgttatcgc ttcgtcagca tatattccgg caagagtcca ctcgttattc
    19381 ttctgtataa attctgtgta gtgttctacc tgagaattat agctgttaat ctgatcttcg
    19441 gtatccgtac taactctgca ataagctgcc actctcttta ttgagcgttc aacacagcct
    19501 gatgcagttc ttttcagtgt ggtatcacct ttaataactt ttacttcttt cttcactgca
    19561 tccgcctcct tttttgtatc tttctatgca gtcttattat accacacttg caaaacatta
    19621 ttaatataat tctgttgaaa tgttgtactt tttcatcagt tttaacttta tcttcctgta
    19681 ttcaatatca tttagtaaat gtttggacag caagatagat agcatagata attggaggct
    19741 atattttagt aattcgttat tcattctaaa ccctcctcgt taaaaatcat ttttaagttt
    19801 tatgacattg gtaggtgctt ggcagcaaca taggaatctc acctccgccc cttattaaga
    19861 cgagccggct taaactattg aagtatcatt atcactactt gtatcaccga acagattgcc
    19921 acctctgttt tttatgtatt cttatttatc gctcgctttc ttatatcctt ggctaaccag
    19981 tattcataaa accgaaaact ttcagcagaa aggtcatggc gtaagtcata attctccaca
    20041 agtagataaa gtcctacctt ggtctattca gttgtcaaag atcaatattt gaaagggatt
    20101 gttttcttta cattttccta tttgccataa gcaggctatc tcttattcaa gaaagtaaag
    20161 gaggtcaaac tccccttcac tttacataag gaaaatttga cccctttggt taccgaattt
    20221 ctaaagttct tcgatgaatt ttttcagctt ttcaagaatt ttgtttcttc ttttgattaa
    20281 agccggatgt gtaatacttt tgagctttgc cactgagcga accgtttcat cattgaaata
    20341 caagcgttca ataatatctc tttcttcagc attaagcctt gatatagcat ttctaactgc
    20401 ttcaatcatc atctgtgttt caacaatctt ttctacatca acactttcat caacaatatt
    20461 atctacaaag tgtccgtcat gatccaatga tgaaaaaaag agcaagtggt tttttctgtc
    20521 cacctgctcc aaatactttt cgtgttctcg ttctcgccag tagactttgt atatctgctc
    20581 gctgacttta accctttgtc cgttgacata aaggtaatat tcttttggca tatatgtttc
    20641 ctccattctt tttttgtctg cttgttttca ggcaaaaaaa ggaggactcc tgcatcttgg
    20701 catgagaagt cctctaaaac gaaagaaact tgttctttta taaacactat ttaatttttc
    20761 aatataattt gtagattcat tatcttctat aaagcaaacc gaaaaaaggg aagaaaatgt
    20821 tcttactatt ttttattatt gaatataaag atttcttcat aatttcctcc ctcattctta
    20881 tatcgaacta atattcatat atccttatat ctaactaata ttcatatatc aaacctttct
    20941 aatagtttat tttcaccttt ggataataag atacttaaca atttatcgct tcttcttttc
    21001 caatttttct aagtctgcta agcattaaaa acaagccgag caaaatcata ctaaaatcta
    21061 caataggttc agcccaccaa actgctaatc ctccaaatac ctttggcaat agcaatatcg
    21121 ccggaataaa taaaatcagt tgtctaagca ttacaatcat gcttgctttt ttcccatctc
    21181 caatagattg gaaaaatgta agagtcataa tcataattcc atacaggata aaggtagaat
    21241 agaacaattt aaagttcata actccagctt caattatttc acttctcaca ttaaacaatg
    21301 acaataattt ttcggagaaa aacatggatg gtatccaaga aatagcagca agtattgttg
    21361 ccccatacat gaaaatcttc atagtatctt ttactctttg atattgtttt gctccaaaat
    21421 tggctcctat aacaggctgt aacccttgac tcattcccca caatggaata aatgagaaca
    21481 tataaagtct cattgttgca gacattagaa ttccccaatt atctccacca taagcgaaag
    21541 cctgtttgaa caaaaatgtt tgttgtactg caaataaaat ttgcatcatc atagccgaac
    21601 ttcctatact aaacatttca ctgtagattg ccttgctctt ttgaatttta tggataccaa
    21661 caaaagcact tttctttgaa aaatagtgaa atgttaatat cgcctgtaca atttgagata
    21721 ttacagttgc aatggctgca ccttcaattg catactctcc catcaacttc ataaaaatag
    21781 gatctaaaat aatatttaat aaagcaccta ctcccataat catcatagat tgcttcaatg
    21841 caccttcacc acgcattgtc atattgcctg cttgagcaaa attcacaaat attgaaccaa
    21901 agaaaactac tcttaaatat ctaactccca gttctttaat atttcctttt gctcctacca
    21961 aatccagaaa attaggtgca aataccaagc ctaatactgt gattactata gagaataaaa
    22021 ttacccaata acaaaaattt ccaaatattt tatccgttgt ttctttatct ccctttccaa
    22081 tagcccttga caaaatcgac gcactaccaa ctccaataag tgctgatata ccaccattta
    22141 ttattgttaa agacatcgat atactaatgg cagacatagc ataatcccct ataatccacc
    22201 cagcaaatat tccatccata aatggataaa gtcctataac aaccattcct ataattcctg
    22261 gaatagctaa ttgaaacaat aaatctttag gactttttgt taaaagttgt gttttcatat
    22321 cttgttttcc catatgactt cctcctattg tttttaatat ttttcagctt atgataactg
    22381 ccacttggtt gctacttgtc ttgcttcaac aaaatttctg taaataccat ctgtttgaat
    22441 tagttcttcg tgtgttcctt tttgcattat ctttccatta gccaatacaa gaatttgatt
    22501 tgcatttttt atagttttta gcctatgtgc aatcataatc acagttttat ttctcgtaag
    22561 ttcctccatt gcaagctgta atttatcctc attttcagga tcaacatttg ctgtggcttc
    22621 atcaaaaata ataattgggg cattttttat catagctctt gctattgaaa ttctttgttt
    22681 ttcaccacct gataaacttg caccaccttc tcctataaca gtttggtatt gttcaggaag
    22741 gttcataata aaatcatgac agcaagcctt tttagcagca tctactactt cttcatgggt
    22801 agcattaggc ttagcaaact ttatattatt ttctatagta tcttggaaca aatacacatt
    22861 ttggaaaacc atactgattt gtttcatcaa tgactctaag gaatattcct ttatattatg
    22921 tcctcctata ctaatcttcc cgttatctat atcccaaaac cttgcaatca agttacaaaa
    22981 tgtggttttt ccagctcctg aaggtccgac tattgcagtc atttggtttt gtggtatatc
    23041 aacagatata tcatcaagaa ttttctttcc tgaatatgca aattctacat tttcaaaaga
    23101 aatattaaaa ttagcaggtt ttatatcttt tccttcaata tccatttgtg gaaattcttc
    23161 taatttcttg gtttgttcaa tagagccact aacaacccta agggcagttg tcgcacttcc
    23221 tgccaattta atttgtgaaa aagcaagaaa tgaaattatg attgtcataa ctgtattcag
    23281 aaacgaaagt tctcctcttt ggtagaagaa aatacctgca cctatgatta aaatgctgaa
    23341 caaatctaaa agaatatttt gaacaatcgt gtaaggtgta aacaactttt cacaatcaag
    23401 atttgttttt ctggtatttt caatagcacc tctaactttc tcatcacctt taccggttaa
    23461 attaaaggat tttataacag acattcctcc aatctgttct aaaacagtat ctactaattt
    23521 tgctgaagcc atttgtcgtt taggaagaac ctctcttgac ttcttttcca tttttgacaa
    23581 aataaccaaa tataatagac ttccgacagt tacaataaaa cctattctcc attcaaatat
    23641 taaaatcatc aaagtaaaga ttatagtatt tataaatccc gacaaggtat ttaccataac
    23701 catcgcagcc gtattttcca catcttctaa aacggttgta gaaataccaa cgacttctcc
    23761 cccattgttt ccattaaaaa atcccatagg aatttttttg aacatttccc ctattgaaat
    23821 tcttttattt gcaaccataa aatagcttgc atggcattgt tgtaactgtg aataataatt
    23881 tgcaatactt ctgcctacta tgcttacaac aagaagtatc aaagcaatcc acgcaggtgt
    23941 catactcata tctttttcag aaacagcttt aactataaaa taaattgcac tgatttgaag
    24001 catgtgaaaa attgcaaaca agaaacttac ccatatagaa tggtatatat ttttcttctc
    24061 atcacctgag aaatctaaaa ttttttttaa agcacttagc attttatttc accatccttt
    24121 actccaatat gagcattcca cattttttta tatagctcac aatcttccat taactcgtta
    24181 tgtttaccat gtgaaataag ctctccattc tcaacaaaaa agatttgttg aacatctgtt
    24241 attgttgata acctgtgtgc aataacgata acagttttat tttgtatcaa ttttgataga
    24301 gcttctttga taatcacctc attctccgga tcaatatatg aagttgcttc atccaatatc
    24361 actatcgggg attttttaag cattgctctt gctattgaga ttctttgtct ttctcctccg
    24421 gaaatatggc taccactgct tccgacaact gtgtcatagc ctttttccat attcataata
    24481 aaatcatggc agcctgactt ctttgcaata ttttcaactt ctttatcact tgcacttgga
    24541 tttcccattc gtatgttttc cctaatgctt tcattaaaaa ggaaattgtc ttgagaaaca
    24601 aatgctacta agctatataa ctgtttaaga ggaatctctt ggagattata tccaccaatt
    24661 tttatgcttc ctgtatttat gtcccaatat cctgctatca gttttgccaa agttgacttt
    24721 ccactaccgc tcggtccaac aaaagctatc gttgtccctt cttctatgtt taacgacact
    24781 ccatgaagaa tttcctttcc ttcttcatat ccaaacttca catcttgcag agcaatatca
    24841 tatttgttta ttttcacatc aacattggaa tgaatttgct cttttccttc taaaattgaa
    24901 ttaatagaat ttgcaatagt tcctatcttt gcaagaccat caacaaaatt catcgtttca
    24961 agtaaaggtc ctgcaattcc taacgacaaa ataataacta ctataaatgt ttctatactc
    25021 aaacttccat tgatgtaaaa ataccagcca accggaagga ttgttatcat tgtagtaggc
    25081 gatatatttt ttgataaaga cacaggaagt tgacagcttc tcatccattc atagaaatac
    25141 tttgcatttg caataacctt atctttatat tttgcatatg accttttatc ctgattgaag
    25201 gttttgatca cttctattcc gttaacatac tccacaattg ccgagttcat ttcacgacta
    25261 acttttacag atccttcata ctgagcagcg tagtttttca tcacaagtcc catgaaaaac
    25321 attcctaaag gaatagaaac taatgacaat aacgccattc tccagtcaag aaataacaaa
    25381 tatatgaata tactcaaaga gcctaatata ttggatgtca tttcaggtaa taagtgtgca
    25441 agaggtttct ccatactttc gacctgatcg actataattt gctttaaatt accgcttgga
    25501 atatttatta tttctcccaa tggcatcttt ggaagtttat caagcattct taaacgaata
    25561 tcttttagta cactaaaagt cgctttatga gatactgata atgctaaaga atataaaatt
    25621 gatttcaaag catatgatag caagcctatg ccaagccaca taagataaac cttgctgtct
    25681 tcaattccat tcactaaata aactaaaatg cgacttgccg caatgtatgg aacaatcccc
    25741 gctaaaacac caatactcgc tataaatact gatgtcttta attttggatg ttcatcatgt
    25801 gcaagctccc acaatattgc agtaggactt ttttctttca tttcaacacc tccatagttc
    25861 tatctattta catttcattt caaaaattca tatattgcac catcgcattg ttttataaat
    25921 tcaaaatcat gcgtgattat aataatagtt tttccttgct ctaccatttg atttaaaaat
    25981 ccaatcaaaa tatccatttg cattttgcaa agtccactcg ttggctcatc aaacactatg
    26041 attggttttt gacttaccat agacatagca agcaacaatc tctgtttttc accacctgat
    26101 aacgaacttg ggtgcatttc ttttttatta aataaatgta cctttcttaa ggcttcattt
    26161 ttcaaattat cctgttttgt aactgttcca atttcctgcc atacagattc tgtgaaaagt
    26221 tgataattaa catcttgcat gactgcaaag atattctcgt accgtttttt gagcttttct
    26281 cccttataaa aaacttctcc cttgcctttt atagttccca taagtaaatt gataaaagta
    26341 cttttcccaa caccgttttg tccaataatg aaatttatcc cggtattaaa agaaacacta
    26401 aaatcaaaaa ttgtattctt atcgtatgtt tttttgaaat gtagacatgt tattgattca
    26461 ttaacaaagt ttgatggagt attttttt
//
LOCUS       DAVHSO010000027        26474 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.027, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000027 DAVHSO010000000
VERSION     DAVHSO010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 26474)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26474)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26474
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.027"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            176..1546
                     /locus_tag="VVR18_001131"
     CDS             176..1546
                     /locus_tag="VVR18_001131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEU6032665.1"
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVG
                     RFLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWIL
                     GALLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLR
                     SIGDSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRK
                     SVPELLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQ
                     TAARRIMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIF
                     LFFASPALVFFLASSTDGYLIENGSLYLQISSAFYPILSLLLIYRNCLQGLGQKILPL
                     VSSFIELIGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAIL
                     ATKVQS"
     gene            1922..2878
                     /gene="lytA"
                     /locus_tag="VVR18_001132"
     CDS             1922..2878
                     /gene="lytA"
                     /locus_tag="VVR18_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HEU6032666.1"
                     /translation="MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWR
                     KDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
                     REQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLAD
                     RWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK"
     gene            3237..3398
                     /locus_tag="VVR18_001133"
     CDS             3237..3398
                     /locus_tag="VVR18_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032667.1"
                     /translation="MYVINVCDVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKG
                     ERNITNGFK"
     gene            3385..3591
                     /locus_tag="VVR18_001134"
     CDS             3385..3591
                     /locus_tag="VVR18_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000366086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032668.1"
                     /translation="MDLSNKAPNLRKKLGADGESPIDIFKLVQKIENLTLVFYGLGKN
                     ISGVCYKGTQFSLIAVNSDMSLGR"
     gene            3637..3996
                     /locus_tag="VVR18_001135"
     CDS             3637..3996
                     /locus_tag="VVR18_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032669.1"
                     /translation="MKKSSVSLILIGEGDETERKADQFASYFLIFPSSLYRMVEEIRE
                     NANRTHLEVEDIIKLGQFYGISHKAMLYRLRNDGYLDAEEIKNMDISVIETASRLGYD
                     TSLYRPLSESKKETVLG"
     gene            4125..4550
                     /locus_tag="VVR18_001136"
     CDS             4125..4550
                     /locus_tag="VVR18_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000204059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032670.1"
                     /translation="MTSRVFIDADCISVFLWVGTEHLLEKLYSGKIVIPQEVYDEINI
                     PTIPHLKSRIDQLVTKGSAEIVSIDIGTEEYALYRDLTRNHDSNKIIGKGEATSIFLA
                     KKHNGILGSNNLRDVKPYVEEFSLEHMTTGDILIEAFKA"
     gene            4958..5542
                     /locus_tag="VVR18_001137"
     CDS             4958..5542
                     /locus_tag="VVR18_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032671.1"
                     /translation="MNVKKIMSIFQSFYVDVSIEELTLTLPISFVKRFEYTQMTFHKE
                     SFLLIKEKRRGSLSSFVTQARTMGDKANMDVVLVFSKLSDGEKKQLLQARVPFVDFKG
                     NLFFPTLGLVLNANDTEVPKELTPSEQLTWIAFLLPDGDIKQIKSVSNLLYGGAYALS
                     HSTFLAETDENTSYVIWQRKFNQLSLPLSQHVLK"
     gene            5546..5743
                     /locus_tag="VVR18_001138"
     CDS             5546..5743
                     /locus_tag="VVR18_001138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032672.1"
                     /translation="MLEIWKYRPFVSEFWNDFKNNHDKQFVDPISLYLTLKDDDDPRI
                     EEKSEALENMILQYLGEDDAS"
     gene            5733..6284
                     /locus_tag="VVR18_001139"
     CDS             5733..6284
                     /locus_tag="VVR18_001139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001111259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032673.1"
                     /translation="MPANTKVIFQEMFADFQNYYVLIGGTATSIVLDSQGFKSRTTKD
                     YDMVIIDEVKNKEFYTTLNHFLELGEYQGSQKDEKAQLFRFTTTNPEFPSMIELFSIL
                     PEYPLKKDGREIPLHFDQDASLSALLLNEDYYNILVHEKETIQGYSVLSNCGLYSSKI
                     SSNHVSFHLQPQNSVLSSLRLAS"
     gene            6343..6603
                     /locus_tag="VVR18_001140"
     CDS             6343..6603
                     /locus_tag="VVR18_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032674.1"
                     /translation="MRERSATGAQGLSKSIKKHLNDITRLTASLLGDEKLSAITSSSA
                     VKADMHRFVIELEPVKSTILQNDDISLDQNEIFEILKNFLDG"
     gene            complement(7329..7725)
                     /locus_tag="VVR18_001141"
                     /pseudo
     CDS             complement(7329..7725)
                     /locus_tag="VVR18_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            7850..8308
                     /locus_tag="VVR18_001142"
     CDS             7850..8308
                     /locus_tag="VVR18_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000186958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4231 domain-containing protein"
                     /protein_id="HEU6032675.1"
                     /translation="MTPEEMYLTERLDVQIAHFLKKSVQHRRRYKVLKITEIVAGFLI
                     AVFCAIPMPGDRYRLISVALSSLGLLCEGIINLYNAKENWISYQKTAQLLEKEKFLYQ
                     CQTEKYAGKTKAFALFVKTCEGLISEEINQWESIQSKEVAASADAPVKKE"
     gene            8321..8929
                     /locus_tag="VVR18_001143"
     CDS             8321..8929
                     /locus_tag="VVR18_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032676.1"
                     /translation="MSQSSYLSPLLWLKKEADKEKMSATQCQIFFFYYQMFELLFARE
                     SDMKDLCLGTKGFYFSQLEKNLLSGVSRFLKNLEGKVTLKANQEVSARKALFLALTTS
                     QSDWQELAPVFDFYQTIGRLENPSLLSSQDRQHLMWIYQSALEKDYIVKVIGDKHFVL
                     KRQDATKLTARQTQTLEILSQSEDLVNPVYVTLGEKGVLLLD"
     gene            9000..9332
                     /locus_tag="VVR18_001144"
     CDS             9000..9332
                     /locus_tag="VVR18_001144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032677.1"
                     /translation="MYICIDNSMTKNKELVKNQTFKPALLTRRLVKNFMIEEPDLARN
                     PFTRPTLIDLDKVFMLDNTVIPTSYLARRRRNVSEELYEEILDYLVQPRLISLNKSEF
                     MQLNPGTY"
     gene            9343..10758
                     /gene="ply"
                     /locus_tag="VVR18_001145"
     CDS             9343..10758
                     /gene="ply"
                     /locus_tag="VVR18_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cholesterol-dependent cytolysin pneumolysin"
                     /protein_id="HEU6032678.1"
                     /translation="MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFV
                     VIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSID
                     LPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQ
                     LKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTV
                     TVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQT
                     EWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTS
                     FLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVL
                     TPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRK
                     RTISIWGTTLYPQVEDKVEND"
     gene            11639..12355
                     /locus_tag="VVR18_001146"
     CDS             11639..12355
                     /locus_tag="VVR18_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU6032679.1"
                     /translation="MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESN
                     SALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSN
                     VNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDD
                     VEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKL
                     YSVLEDDEDVQKIYTNVDGF"
     gene            12479..12928
                     /locus_tag="VVR18_001147"
                     /pseudo
     CDS             12479..12928
                     /locus_tag="VVR18_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809294.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
     gene            12967..13788
                     /locus_tag="VVR18_001148"
     CDS             12967..13788
                     /locus_tag="VVR18_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032680.1"
                     /translation="MILLAILFTCFSVYLELEVPTYISKITDLLGSQETNLDELWQPA
                     SMMMGMSFLAFLSVVAVGFFASRVAASYTSRLRSDIFNRVLDYSQTEIKKFSIPSLLT
                     RTTNDITQVQMLITMGLQVVTRGSIMAIWAIGKILGHSEYWLWAVLVVVIVNVLMTTV
                     LMTLAFPKQSLIQGLTDKLNSITRESLTGIRVVRAYNAEDYQNEKFAAVNDELTRLNL
                     FVNRLMAILNPIMMGISSGLSVAIYWIGAYVINDAAPIARLPLFSDMIIFMSYAM"
     gene            13795..14826
                     /locus_tag="VVR18_001149"
     CDS             13795..14826
                     /locus_tag="VVR18_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000506433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6032681.1"
                     /translation="MGFLLMGALFIVLPRTMVSAKRINQVLDLHSSIQNPVQVQLTDE
                     NFKGQVEFKDVTFRYAANSEAVIEHVSFKAETGQTVAFIGSTGSGKSTLVNLIPRFYD
                     VSAGEILVDGVNVQDYDFSATAHAGQKVAIVGPTGTGKTTIVNLLMKFYEIDKGSIHI
                     DGVDTKAMTRSEVHDAFSMVLQDTWLFEGTIRDNLIYNQIGISDERMMEASKAVGIHH
                     FIMTLPDGYDTILDDTVTLSVGQKQLLTIARTLLKDAPLLILDEATSSVDTRTEELIQ
                     KAMDRLMEGRTSFVIAHRLSTIRNADLILVMKDGNIIEQGNYEELMAQGGFYADLYNS
                     QFTEDEAEE"
     gene            14892..15254
                     /locus_tag="VVR18_001150"
     CDS             14892..15254
                     /locus_tag="VVR18_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2200 domain-containing protein"
                     /protein_id="HEU6032682.1"
                     /translation="MSQKLYNMKFAAVYLALIAKVERKGGKAESVHQVTSWLTGYEVS
                     DVLACLDRDVTYGDFFRQAPYYVPERIAITGKICGVRIEEIDDPLMQEIRRLDKLVDW
                     LAKGKTSQQVLEKYEKHK"
     gene            15251..15754
                     /locus_tag="VVR18_001151"
     CDS             15251..15754
                     /locus_tag="VVR18_001151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEU6032683.1"
                     /translation="MKNYQEWYRNISSRLTSRPILLFLLRSFNRLMTVAMPLVYLILL
                     VTTYLQLGLGQQVGVYVLIPASGFVALSLFRKKINHPRPYETWNTCPLLDKDSSGRSM
                     PSRHVFSATIISMACLHASLPIGLVCLNFSALLGLVRVLGGVHYPKDVLVGYACGLVW
                     GFLFFLF"
     gene            15868..16314
                     /locus_tag="VVR18_001152"
     CDS             15868..16314
                     /locus_tag="VVR18_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032684.1"
                     /translation="MKLRIEIDGNLEETEIVIKTPTLTDEIADLQRLLQESKSPRLIF
                     YKGTGEYYLDLSEILFFETEGSKIYAHTQKNAYEVRLKLYELEAILPRYFSRVSKSTI
                     VNIRQIYSVDKSFSGTGTISFYQTHKEVHVSRHYQSLLKENLRNMR"
     gene            16319..16993
                     /locus_tag="VVR18_001153"
     CDS             16319..16993
                     /locus_tag="VVR18_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032685.1"
                     /translation="MKKKAFGIVLLVLAALILVQGNFGIPSLGGHIWPLIGIAFFAYQ
                     SVGALLRRHLTSASFTALVALMIANHFYGILPIPNQTLIWAGVLIVLGVNMLTHSNRT
                     WNGKKWWYDGEKNILIDKEVAFGTGTFYKQDQELVEDQVEVGFGNAKIYYDNAEMLGD
                     FATLNIEVAFGNATVYVPQHWRVDLKVETSFGAAKADAPVAPTSKTLIIRGDVAFGKL
                     EIVYAK"
     gene            17154..17345
                     /locus_tag="VVR18_001154"
     CDS             17154..17345
                     /locus_tag="VVR18_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein"
                     /protein_id="HEU6032686.1"
                     /translation="MYYSVDDVVSNAFKKRMILDSFFAFNCSGTMKVSTWVYDKGEWY
                     YVSSSGSMIANDWVKDNGK"
     gene            17630..17929
                     /locus_tag="VVR18_001155"
     CDS             17630..17929
                     /locus_tag="VVR18_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4651 domain-containing protein"
                     /protein_id="HEU6032687.1"
                     /translation="MNGMKAKKMWMAGLALLGIGSLALATKKVADDRKLMKTQEELTE
                     IVRDHFSDMGEIATLYVQVYESSLESLVGGVIFEDGRHYTFVYENEDLVYEEEVL"
     gene            17926..18243
                     /locus_tag="VVR18_001156"
     CDS             17926..18243
                     /locus_tag="VVR18_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HEU6032688.1"
                     /translation="MIQPASLEELASLVEKAGKKVFLFVADWCGDCRYIYPALPEIEE
                     TNPEFTFIRMDRDQYMDLAKLWDVYGIPSLVVLEKDKEIGRFVNRDRKSKEQINDFLA
                     GLK"
     gene            18259..18885
                     /locus_tag="VVR18_001157"
     CDS             18259..18885
                     /locus_tag="VVR18_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4479 and tRNA-binding domain-containing
                     protein"
                     /protein_id="HEU6032689.1"
                     /translation="MIFTYNKEHVGDVLMVIVKNSGDAKLNVERKGKVARVFLKENGE
                     TVAWNIFEVSSLFEIAERGQVFLSDEQVARLNQELQAEGFTEEIVNDKEPKFVVGEIV
                     EMVAHPDSDHLNICQVAVASDKIVQIVAGAPNARVGLKTIVALPGAMMPKGNFIFPGE
                     LRGEKSFGMMCSPRELHLPNAPQKRGVLELSEDQVVGTPFDPAKHWTA"
     gene            18918..19679
                     /locus_tag="VVR18_001158"
     CDS             18918..19679
                     /locus_tag="VVR18_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HEU6032690.1"
                     /translation="MAKNVVITGATSGIGEAIARAYLEQGDDVVLTGRRIDRLEILKS
                     EFAVSFPNQTVWTFPLDVTDMVMVKTVCSDILETIGRIDILVNNAGLALDLAPYQDYE
                     ELDMLTMLDTNVKGLMAVTHCFLPAMIKVNQGHIINMGSTAGIYAYAGAAVYSATKAA
                     VKTFSDGLRIDTIATDIKVTTIQPGIVETDFSTVRFHGDKERAASVYQGIEALQAQDI
                     ADTVVYVTSQPRRVQITDMTIMANQQATGFMIHKK"
     gene            19757..20152
                     /locus_tag="VVR18_001159"
     CDS             19757..20152
                     /locus_tag="VVR18_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEU6032691.1"
                     /translation="MYNKVIMIGRLTSTPELHKTNNDKSVARATIAVNRRYKDQNGER
                     EADFVNMVLWGRLAETLASYATKGSLISVDGELRTRRFEKNGQMNYVTEVLVTGFQLL
                     ESRAQRAMRENNAGQDLADLVLEEEELPF"
     gene            20422..20706
                     /gene="groES"
                     /locus_tag="VVR18_001160"
     CDS             20422..20706
                     /gene="groES"
                     /locus_tag="VVR18_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HEU6032692.1"
                     /translation="MLKPLGDRVVLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQG
                     VRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE"
     gene            20722..22344
                     /gene="groL"
                     /locus_tag="VVR18_001161"
     CDS             20722..22344
                     /gene="groL"
                     /locus_tag="VVR18_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166362.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HEU6032693.1"
                     /translation="MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFG
                     SPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREG
                     IKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYI
                     SEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYI
                     LITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKA
                     PGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGA
                     GNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKL
                     RIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQ
                     IAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVA
                     SLILTTEAVVANKPEPVAPAPAMDPSMMGGMM"
     gene            22482..23237
                     /locus_tag="VVR18_001162"
                     /pseudo
     CDS             22482..23237
                     /locus_tag="VVR18_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000567550.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase QueH"
     gene            complement(23677..24210)
                     /locus_tag="VVR18_001163"
     CDS             complement(23677..24210)
                     /locus_tag="VVR18_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF402 domain-containing protein"
                     /protein_id="HEU6032694.1"
                     /translation="MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDH
                     TLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYI
                     DYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFS
                     EAYVNIWYKRYVELKNR"
     gene            complement(24299..25075)
                     /gene="recX"
                     /locus_tag="VVR18_001164"
     CDS             complement(24299..25075)
                     /gene="recX"
                     /locus_tag="VVR18_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000705102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HEU6032695.1"
                     /translation="MKITKLEKKKRLYLMELDNGDKCYITEDTIVRFMLSRDKVISEE
                     ELKEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDENIVSQVIANLKEDKW
                     INDGQYAYAIINTNQLSGDKGPYVLTQKLAQKGISKSTIEENLKEFDFSEVAQRVANK
                     LLKKYEGKLPARALQDKIIQNLTNKGFSYSDAKIAFDDLDSQVEQETTQELIFKELDK
                     QYTKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL"
     gene            25113..26468
                     /gene="rlmD"
                     /locus_tag="VVR18_001165"
     CDS             25113..26468
                     /gene="rlmD"
                     /locus_tag="VVR18_001165"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEU6032696.1"
                     /translation="MNLKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYC
                     QITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQ
                     ALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELK
                     DCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNR
                     QLNLTQLVKELVKGFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLDYEFSL
                     SPRAFYQLNPEQTEVLYSEVVKALDVSKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDI
                     IPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLL
                     DTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKK
                     V"
BASE COUNT         8085 a         4636 c         5741 g         8012 t
ORIGIN      
        1 agcagctaca gcgtactatt ccaaactcaa ccaactataa tagatcgaaa ctagaatagt
       61 acacatctac ttctaaaaca ttgttaaaaa tcgatttgac tttccttatt tcattccgct
      121 atatataagt ttgctgtttc ttgtcgctcc tctaggaagc tgatataata gctttatgaa
      181 taaaaaacga acagtggacc tgatacatgg tccgattctt ccctcgctct taagcttcac
      241 ctttccaatc ttgctatcaa atatttttca acagctctat aacactgctg atgtcttgat
      301 tgttggacga tttcttggtc aagaatcctt ggctgcagta ggagcgacga cagcgatttt
      361 tgacctgatt gtaggtttta cacttggtgt tggcaatggc atggggattg tcattgctcg
      421 ttattatgga gctcggaatt tcactaaaat caaggaagca gtagcagcca cttggatttt
      481 aggtgctctt ttgagcattc tagttatgtt gctgggcttt cttggtttgt atcctctctt
      541 gcaatactta gatactcctg cagaaattct tcctcaatct tatcaatata tttctatgat
      601 tgtgacctgt gtaggtgtca gctttgctta taatcttttt gcaggcttgt tgcggtctat
      661 tggtgacagt ctagcagccc tgggatttct gattttctct gccttggtta atgtggttct
      721 ggatctctat tttattacgc aattgcatct gggagttcaa tccgcaggac ttgctaccat
      781 tatttcgcaa ggtttatcag cggttctctg cttttattat attcgtaaaa gtgtgccaga
      841 actcttgcca cagtttaaac atttcaaatg ggacaaaagc ttgtacgcgg atctcttgga
      901 gcaaggtttg gctatgggct tgatgagttc aattgtatct atcggcagtg tgattttaca
      961 gttttctgtt aatacatttg gtgcagtgat tattagtgcc cagacggcag ctcgacgcat
     1021 tatgaccttt gcccttcttc ctatgaccgc tatttctgca tcaatgacga cctttgcttc
     1081 tcagaatcta ggagctaagc gacctgaccg cattgttcaa ggtcttcgaa tcggcagtcg
     1141 tttaagtata tcctgggcag tttttgtttg tattttcctc ttttttgcca gtccagcttt
     1201 ggttttcttc ttggctagtt cgacagatgg ttacttgata gaaaatggaa gtctctatct
     1261 gcaaatcagt tcagcctttt atcccatttt gagcctcttg ttgatttatc gcaattgctt
     1321 gcagggcttg gggcagaaga tccttcctct agtttctagc tttattgaac taatcggaaa
     1381 aatcgttttt gtggttttga ttattccttg ggcaggatat aagggtgtta tcctttgtga
     1441 acctcttatc tgggttgcca tgacagttca actgtacttc tcactattcc gtcatccctt
     1501 gataaaagaa ggaaaggcaa ttttggcaac caaagtgcaa tcctagttgg atttactgaa
     1561 taaaatccat ttcctctagt gaacatcgaa aaaacttgtg ttctcttctt tagtttggtg
     1621 ttgaaaatag tttaacagac ttttgacttc ttttatatga tataataaag tatagtattt
     1681 atgaaaagga catatagaga ctgtaaaaat atacttttga aaagcttttt agtctggggt
     1741 gttattgtag atagaatgca gaccttgtca gtcctattta cagtgtcaaa atagtgcgtt
     1801 ttgaggttct atctacaagc ctaatcgtga ctaagattgt cttctttgta aggtagaaat
     1861 aaaggagttt ctggttctgg attgtaaaaa atgagttgtt ttaattgata aggagtagaa
     1921 tatggaaatt aatgtgagta aattaagaac agatttgcct caagtcggcg tgcaaccata
     1981 taggcaagta cacgcacact caactgggaa tccgcattca accgtacaga atgaagcgga
     2041 ttatcactgg cggaaagacc cagaattagg ttttttctcg cacattgttg ggaacggttg
     2101 catcatgcag gtaggacctg ttgataatgg tgcctgggac gttgggggcg gttggaatgc
     2161 tgagacctat gcagcggttg aactgattga aagccattca actaaagaag agttcatgac
     2221 ggactaccgc ctttatatcg aactcttacg caatctagca gatgaagcag gtttgccgaa
     2281 aacgcttgat acagggagtt tagctggaat taaaacgcac gagtattgca cgaataacca
     2341 accaaacaac cactcagacc acgttgaccc ttatccatat cttgctaaat ggggcattag
     2401 ccgtgagcag tttaagcatg atattgagaa cggcttgacg attgaaacag gctggcagaa
     2461 gaatgacact ggctactggt acgtacattc agacggctct tatccaaaag acaagtttga
     2521 gaaaatcaat ggcacttggt actactttga cagttcaggc tatatgcttg cagaccgctg
     2581 gaggaagcac acagacggca actggtactg gttcgacaac tcaggcgaaa tggctacagg
     2641 ctggaagaaa attgctgata agtggtacta tttcaacgaa gaaggtgcca tgaagacagg
     2701 ctgggtcaag tacaaggaca cttggtacta cttagacgct aaagaaggcg ccatggtatc
     2761 aaatgccttt atccagtcag cggacggaac aggctggtac tacctcaaac cagacggaac
     2821 actggcagac aagccagaat tcacagtaga gccagatggc ttgattacag taaaataata
     2881 atggaatgtc tttcaaatca gaacagcgca tattattagg tcttgaaaaa gcttaatagt
     2941 atgcgttttt ttgtggagat atttccttca atgtttgcta ctatattaaa caaaaatcag
     3001 aaagcaaact agaaagttat gctcaaataa aatctaaatt tgacaatgta aaccgagtcg
     3061 gatagcttta agtactgttt tgaggttgaa gatacgattt ttgataggaa ctcatcaatt
     3121 ttagattttt aagcagcatc aataaattgc ttccttgttt tgtcataatt tttttattta
     3181 aaaaattatg acaagagtgt gctattcttt ttatgagagg tgtatgaata tgataaatgt
     3241 atgtgataaa tgtatgtgat gttggaaaaa gaataaaaga acttagaata tcttcaaatc
     3301 ttactcaaga taagattgct gagtatttgt ctttgaatca aagcatgatt gccaaaatgg
     3361 aaaaaggtga aaggaatatc acgaatggat ttaagtaata aagctccaaa tcttagaaaa
     3421 aagttgggag ctgatggtga atcgccgata gatattttta aattggtaca aaagatagaa
     3481 aatttgacgc tggtatttta tggactcgga aagaatatta gcggagtctg ttataaagga
     3541 actcagttca gtctcattgc agtcaattca gacatgtcat taggaaggta aagattttct
     3601 ttagcacatg aactgtatca tctttattat gatgaggtga agaagagttc agtcagtctt
     3661 atcttgattg gtgaaggaga tgaaactgaa agaaaagcgg atcagtttgc ttcttatttt
     3721 ttaattttcc catcttcact gtataggatg gttgaggaaa tcagagaaaa tgccaataga
     3781 actcatcttg aagtagaaga tattataaaa ttgggtcagt tttatggtat cagtcataaa
     3841 gctatgttat atagattgag gaatgatgga taccttgatg cagaagaaat taaaaatatg
     3901 gatattagtg ttatagagac agcttcaaga ttaggctatg atacaagttt atatcgtcct
     3961 ttgtcagaaa gtaaaaagga aacggtatta ggataatata ttaattcaac tgaacaactt
     4021 ttagaaaata acagaatttc gcaagggaag tatgaggaac tgttactaga tgctttcaga
     4081 tatgatattg tatatgggct atatgaagag gggggagttg tcgtttgact agtcgtgtat
     4141 ttattgatgc agattgtatt tcagtatttt tatgggttgg tactgaacat cttttagaaa
     4201 agctctattc gggtaaaatt gttattccac aagaggtgta cgatgaaatc aatataccta
     4261 caattcccca tttaaaatct aggatagacc agttggtaac taagggttca gctgagattg
     4321 tgagcataga cattggaact gaagaatacg cattatatag agatttaaca agaaatcatg
     4381 atagtaacaa gattattggt aagggagaag cgacttctat tttcttagcg aaaaagcata
     4441 atgggatatt aggaagtaat aacctaagag atgttaaacc atatgtagaa gaattttctt
     4501 tagaacatat gacaacagga gatatactga ttgaagcgtt taaagcgtaa tttattactg
     4561 aacaagaggg caatcatatc tggaataata tgcttaaaaa gagaaggaaa attggtgcaa
     4621 attcattttc agactatctt cgtggaagta ttcatcaaaa tagacaaaaa taaatttgga
     4681 taaatcgaac tcactattca ggaggcatat gagcaattcg aaaaagaaaa gtgtcaaatt
     4741 gagcctatag gagtagaagt gaaatagtaa gtcctgcata gtggatgaga gaaaagttct
     4801 ccttgaagtt ttcctgaact atcagtcgca tgtcaaacga tatgtagggt agtgtgagag
     4861 gggataggga gtagtttttg gttattttat caaaaaactt atattttatt ataccgaatg
     4921 ataaaatata ataaaaatga tagaataagg aaaaaacatg aatgtcaaaa agataatgtc
     4981 aatttttcaa tccttttatg ttgatgtcag tattgaggaa ctgactttga ctttaccaat
     5041 cagttttgta aaaaggtttg agtatactca aatgactttt cataaggaat catttttatt
     5101 gattaaagaa aagagaaggg ggagtttgag ttcatttgtt actcaagctc gcactatggg
     5161 tgataaagcc aatatggatg ttgttttggt gttttcgaag ttatcagacg gtgaaaaaaa
     5221 gcaattactt caagctagag ttccgtttgt agactttaag ggaaacctct tcttccctac
     5281 attgggacta gtactgaatg cgaatgatac tgaagtccct aaggaattaa cacctagcga
     5341 acaattaacg tggattgcct ttttattgcc agatggcgat ataaagcaga taaaatctgt
     5401 ttctaacctt ctatatggtg gtgcttatgc tttgtcgcat tcaacttttt tagctgaaac
     5461 ggatgaaaat actagctatg tcatatggca gagaaaattc aatcagttat ccttgccact
     5521 ttctcagcat gttttaaaat gaaagatgct agagatatgg aaatatcgtc cttttgtatc
     5581 tgagttttgg aatgatttta aaaataatca tgataaacaa tttgtagatc cgatttctct
     5641 ttatttgacc ttaaaagatg atgatgaccc acgtatagag gaaaagagtg aagcactaga
     5701 aaatatgata ttacagtatc tgggagaaga tgatgccagc taatacgaaa gttatttttc
     5761 aagaaatgtt tgcggatttt cagaactatt atgttctgat tgggggaact gctacctcta
     5821 tcgtattgga ttcgcaagga tttaaaagtc gcacaacaaa agattatgat atggtcatca
     5881 ttgatgaagt aaaaaataag gaattttata ctaccttgaa tcatttttta gaattgggag
     5941 agtatcaagg aagtcagaaa gatgagaaag cgcagctttt tcgatttaca acaactaatc
     6001 ctgagtttcc ttctatgatt gaactattta gtatcttacc agaatatcca ttaaagaagg
     6061 acggtcgaga aattccctta cattttgacc aagatgctag tttatcagcc ttattattga
     6121 atgaagatta ttataatata ttggtgcatg aaaaagaaac cattcagggg tattcggtat
     6181 tgagtaattg tggtctatac tcttcgaaaa tctcttcaaa ccacgtcagc ttccatctac
     6241 aacctcaaaa cagtgttttg agcagcctgc ggctagcttc ctagtttgct ctttgatttt
     6301 cattgagtat taattatttt taaggctaaa gcttggctgg atatgaggga acgctctgct
     6361 acaggtgctc aaggtttaag taagtccatt aaaaagcatt tgaatgacat tacccgtttg
     6421 acagcttcct tgctaggaga tgaaaagtta tcggctataa catcaagtag tgcggtaaaa
     6481 gcagacatgc accgctttgt gatagaatta gagcctgtga agtcaactat tcttcaaaat
     6541 gatgacattt cattggatca aaatgaaatt tttgaaattc tgaaaaattt tctcgatggt
     6601 taaaataatt gtagcgagat ggctatattg aattcgttta tatctggaaa ctagaaaaaa
     6661 cttcaatttc aggagaaaat gaagtcaatc ttcccacaat caaacgtata gtatcaaggt
     6721 ttttcaagac ctgatattat gcgttttttg cttttcaaaa ctttttgccc agtctttgtt
     6781 tttatcctct agtcacttga tttgtttcag gtggtttttt agtatagtaa aatgaaacga
     6841 gaacaggaca aattgttcag gacagtcaaa tcgatttcta acaatgtttt agaagcagag
     6901 gtgtactatt ctagtttcaa tctacggtca agtctactgg ttaatctatg attgtaatac
     6961 tcttccaaaa tctcatcaac cacgtcagtc ttgccttgca gtctgtatct tactgaccaa
     7021 gctagtgatg gacttagaat aggtgatttg gagcgtccta ttggctagga aatgctgatc
     7081 atagtccttt gctgaggcta gggtgtttca acattcaaca ctcaactggt tgatctagtt
     7141 gataggaagg gaattactat aaaatactca ggcttccatc atattttttg aaacgattgt
     7201 gtaatcaaaa tgtaccaata ttgtagtatt ggtacagaag atgttgtgaa tggataaata
     7261 tatcataact gctgtctcaa aaagatttca tatgtctgtg catatataat agacttcctg
     7321 cgaaaccaaa atcctagttc atgattgata ataccagcaa tcaaatttat tcgtaatccg
     7381 aagcgtttac gatgatttcg ataggttgtt gaaaacattt taaacgtttt tactttggca
     7441 aagatgttct caaccttgct tctctcctta gatagcgcat ggttacaggc tttatcttca
     7501 attgttagcg gcttgagttt gctggattta cgtggagttt gtgcttgagg atatatcttc
     7561 atgagccctt gataaccact gtcagccaag attttaccag cttgtctgac ttttttgata
     7621 agctgttttt aatacagcta acatctcttc aaaagtggta cgctgaacac caacaagacg
     7681 cttaaatcgt gcatcagtta gttgtttact tgcttcataa ttcatagaac tactatacca
     7741 tattttgttt cgcaggaagt ctaataagtt atagtccagt ttttactata ctttgatatt
     7801 caaatatgtt atactatggt tatcaaagta aatgaaagga gttacgaata tgacgccaga
     7861 agaaatgtac ctgacagagc gattagacgt acagatagct cattttttaa agaaaagcgt
     7921 tcaacatcgt aggcgctata aggtattaaa aataacagaa atcgtggcag gtttcctcat
     7981 agctgtcttt tgtgctattc ctatgccagg tgatcgctac cgtttgattt cggttgcctt
     8041 atccagtctc ggcttgctgt gtgaggggat tatcaatttg tataatgcaa aggaaaattg
     8101 gatttcttac caaaaaactg cgcaactcct ggagaaagaa aaattcctct atcaatgcca
     8161 aacggaaaaa tatgcaggaa agaccaaggc ttttgcccta tttgtcaaga catgcgaagg
     8221 tcttatctca gaggagatta accagtggga aagtatccag tcaaaagaag tggcagctag
     8281 tgcagatgct ccagttaaaa aagagtagga ggtagaggaa atgtctcaat ccagctacct
     8341 gtcgcccttg ctctggttaa aaaaagaagc cgataaggaa aagatgagcg cgacccagtg
     8401 ccagatattt ttcttttact atcaaatgtt tgagctctta tttgctagag aaagcgacat
     8461 gaaagactta tgtctgggaa cgaaaggttt ttatttctcg cagttagaga aaaatttgct
     8521 ttctggagtt tcccgatttc taaaaaactt ggaggggaaa gtaactctca aggctaacca
     8581 agaagtatca gctcgcaaag ccctttttct agccttgaca actagccaat cagattggca
     8641 ggagttagct cctgtttttg atttttatca gactatcggg aggcttgaaa atccttctct
     8701 cttgagttct caggacagac aacatctgat gtggatttac cagtcagctt tggagaagga
     8761 ttatattgtc aaggttattg gcgacaagca ttttgtattg aagagacaag atgctactaa
     8821 attgacagcg cgccaaactc aaactttgga aattctgagt caatcagaag acttggtcaa
     8881 tcctgtctat gttacattag gagaaaaggg ggtgctcttg cttgattaag agaggagatg
     8941 ttgtagctct ttatttgcct tttccgacta ttagtagcga tttggctgtg aagaatcata
     9001 tgtatatctg tattgacaac agcatgacta aaaacaaaga gttggttaaa aatcagacct
     9061 tcaaaccagc tctcttgacc agacgtttgg tcaagaactt tatgatagaa gagccagatc
     9121 tagctcgtaa tccttttaca agaccaacct tgattgactt agataaggta tttatgttgg
     9181 ataatacggt cattccgact tcttatctag ccagacggcg acgcaatgtc tcagaagaat
     9241 tgtacgagga aattttggat tacttagtcc aaccacggct gatttcgctg aacaagtctg
     9301 agtttatgca actcaatcca ggaacttatt aggaggtaga agatggcaaa taaagcagta
     9361 aatgacttta tactagctat gaattacgat aaaaagaaac tcttgaccca tcagggagaa
     9421 agtattgaaa atcgtttcat caaagagggt aatcagctac ccgatgagtt tgttgttatc
     9481 gaaagaaaga agcggagctt gtcgacaaat acaagtgata tttctgtaac agctaccaac
     9541 gacagtcgcc tctatcctgg agcacttctc gtagtggatg agaccttgtt agagaataat
     9601 cccactcttc ttgcggtcga tcgtgctccg atgacttata gtattgattt gcctggtttg
     9661 gcaagtagcg atagctttct ccaagtggaa gaccccagca attcaagtgt tcgcggagcg
     9721 gtaaacgatt tgttggctaa gtggcatcag gattatggtc aggtcaataa tgtcccagct
     9781 agaatgcagt atgaaaaaat cacggctcac agcatggaac aactcaaggt caagtttggt
     9841 tctgactttg aaaagacagg gaattctctt gatattgatt ttaactctgt ccattcaggc
     9901 gaaaagcaga ttcagattgt taattttaag cagatttatt atacagtcag cgtagacgct
     9961 gttaaaaatc caggagatgt gtttcaagat actgtaacgg tagaggattt aaaacagaga
    10021 ggaatttctg cagagcgtcc tttggtctat atttcgagtg ttgcttatgg gcgccaagtc
    10081 tatctcaagt tggaaaccac gagtaagagt gatgaagtag aggctgcttt tgaagctttg
    10141 ataaaaggag tcaaggtagc tcctcagaca gagtggaagc agattttaga caatacagaa
    10201 gtgaaggcgg ttattttagg gggcgaccca agttcgggtg cccgagttgt aacaggcaag
    10261 gtggatatgg tagaggactt gattcaagaa ggtagtcgct ttacagcaga tcatccaggc
    10321 ttgccgattt cctatacaac ttctttttta cgtgacaatg tagttgcgac ctttcaaaat
    10381 agtacagact atgttgagac taaggttaca gcttacagaa acggagattt actgctggat
    10441 catagtggtg cctatgttgc ccaatattat attacttgga atgaattatc ctatgatcat
    10501 caaggtaagg aagtcttgac tcctaaggct tgggacagaa atgggcagga tttaacggct
    10561 cactttacca ctagtattcc tttaaaaggg aatgttcgta atctctctgt caaaattaga
    10621 gagtgtaccg ggcttgcctg ggaatggtgg cgtacggttt atgaaaaaac cgatttgcca
    10681 ctagtgcgta agcggacgat ttctatttgg ggaacaactc tctatcctca ggtagaagat
    10741 aaggtagaaa atgactagga gaggagaatg cttgcgacaa aaagatgcga tgatctctct
    10801 gcggatatct gaaagtttat ctcttgccta gcgatttcca ttggagtatg ctcgtgatgt
    10861 taaaatgaat ctatcaaaca gaatgtgtaa aaaagtaaaa agggtagcca attccttgat
    10921 atacagggga ttgattatcc tttacttgtt ttagatgatt ggaaattcaa gaacgacacg
    10981 tatcggaaat attttgctgt ttatatctaa tacccattta tggaaaaaat gaaattaaat
    11041 atgaacaaat caattgctag caatggttta gaagtgccag tgtactagtc taacttctcc
    11101 atcttgggaa cacgtaaatt atactcttcg aaaatctctt caaaccaggt cagccctatc
    11161 cgcaacctca aaacagtgtt ttgagcaacc tgcggctagc tttctagttt gctctttgat
    11221 ttttattgag tattagaggt ttgcttagaa actcgtctat taatttctta gaatacaata
    11281 gcgcctataa gaactgttgg attgcaaagt atttactgga actatgatat gtctggagta
    11341 gactgtcaac aaaaggtgca gtatgattgt ttttgtcgct tatatctaca aacttcaaac
    11401 agtaatttga gctgactttg tcaaacttgg ctgaaacttt ctatttgcag ataatggtct
    11461 agtttgtttt ttgaatgtgg atgagtgtct gttgataaag atagaaaggt aagaccatct
    11521 tagcaggtaa agtgctatcc tagcttgatt tgctaataaa atccatttcc tctagtgaaa
    11581 atcaaaaaaa cttgtgttat aataataaag attaaaatgt gaaaaaagga gattcctaat
    11641 gggacgtaaa tgggccaata tcgtagccaa gaaaacggct aaagatggag ctaactctaa
    11701 ggtatatgca aaatttggtg tagaaatcta tgtagcagct aaaaaaggtg atccagatcc
    11761 agaatcaaac tcagctttga aattcgttat cgaccgtgct aaacaagccc aagtgccaaa
    11821 acacattatc gataaagcga ttgataaagc caaaggaaac acagacgaaa cctttacaga
    11881 aggacgttac gaaggttttg ggccaaatgg ctctatgcta attgtggata ctttgacttc
    11941 taacgtcaac cgtacagcag ccaatgtccg tgcagccttt ggtaaaaacg gcggaaacat
    12001 gggcgcttca ggttctgttt cttacctctt tgacaacaaa ggtgttattg tatttggagg
    12061 tgaagatgca gacgcagtct ttgagcaatt gctcgaagcg gatgtggatg tggatgacgt
    12121 agaagcacaa gaaggtacaa tcacagttta cacagcgcca actgaccttc acaaggctat
    12181 cgttgccctc cgtgagtctg gtattgaaga attccaagtg actgaattgg aaatgattcc
    12241 tcagtcagaa gtggaattgt caggcgaaga ccttgaaacc tttgaaaaac tttacagcgt
    12301 tcttgaagac gacgaagacg tccaaaagat ttatacgaac gtagatgggt tttaatttaa
    12361 cctatagaac atgatcctaa gtgagaaaat cacttgggat ttttttaatc aagaaaatag
    12421 ttctcataga aatttaatta ttctccagag aactattttt atttagaagg gggagattat
    12481 gggtaaaccg atgttagtct ttaagcgttt tggtcatcaa attcacctga tggtgcaaaa
    12541 ggaagccaaa cgttgcggca ttgaatttat gggtgggccg caaggttagg ttgtgcgttt
    12601 tttggataat cgcgagaaaa accaagattt ggtcttgatt aaagatatcg atcaggaact
    12661 caatattacc aagtctgttg ctagtaatct ggttaagcgt atagtgcaaa atggtttggt
    12721 ggaattggag gcgagtcctg ttgataagcg ggctaagttt gttcgtctga cggacaaagc
    12781 acgttctcag atgcaacagg ttaaggcttt ttttgaacgc atagacaagc agttgatgga
    12841 agacattgat gaagatgaat tactgatttt tgagaaggtt ctcggtcaac tacaggcaaa
    12901 atatcaaggg aataggagga gagaataaag aaattagcca aaagaattag tagaaaagaa
    12961 tgggggatga ttttactagc cattctcttt acttgctttt cggtctatct agagttggaa
    13021 gtgccgacct atatctcgaa aattacggat ttgctaggta gtcaagaaac taatttagat
    13081 gagttgtggc agccggcaag catgatgatg ggaatgtcct ttcttgcctt cttgtccgta
    13141 gttgcagttg gattttttgc atcccgagtg gcggcttctt atactagtag gctgagaagt
    13201 gatattttta accgagtttt ggattactcg cagacagaga ttaagaaatt ttcaattcct
    13261 agcctcttga cgcgtactac caatgacatt actcaagttc aaatgttgat tactatgggc
    13321 ttgcaagtgg taacgcgtgg ttcaattatg gctatctggg ctattgggaa gattttaggt
    13381 cattcagaat actggctctg ggccgtactt gtggtagtga ttgtcaacgt cctgatgacg
    13441 accgttttga tgacgctagc ctttccaaaa cagtccttga ttcaggggtt gacagataaa
    13501 ctgaacagta tcactcgtga gagtttaaca ggtattcgtg tcgttcgtgc ctacaatgca
    13561 gaggattatc aaaatgaaaa atttgcagca gtaaatgatg aattgacccg tttgaatttg
    13621 tttgtcaacc gtcttatggc tattttgaat cctatcatga tggggatttc aagtggtttg
    13681 agtgtagcga tttactggat tggggcctat gtgattaacg acgctgctcc gatagcgcgt
    13741 ctgcctctct ttagtgacat gattattttc atgtcttatg ccatgtaggt tgtcatgggc
    13801 ttccttctca tgggagcact cttcatcgtt cttccccgaa ctatggtctc tgctaagcgg
    13861 attaatcaag ttttagattt gcattcttct atccaaaacc ctgttcaagt acagctgact
    13921 gatgaaaact tcaaaggtca ggtcgagttt aaggatgtga ccttccgcta tgcggcaaat
    13981 tcggaggcag ttattgaaca tgttagcttt aaagcagaaa ctggtcaaac agtggccttt
    14041 attgggtcaa caggttctgg taaatcaact ctggtcaatc tgattccacg tttctacgac
    14101 gtgtcagcag gagaaattct ggtggacggt gtcaatgttc aagactatga cttctctgcg
    14161 acagctcatg ctggtcaaaa ggttgccatt gttgggccga ctgggactgg taagacaacc
    14221 attgtcaatc ttttgatgaa attctatgag attgataagg gaagtattca cattgatggt
    14281 gtggatacca aggctatgac gcgttcagaa gtgcatgatg ccttttcaat ggtcttgcag
    14341 gatacctggc tctttgaagg aactattcga gacaatctca tctataatca aatagggatt
    14401 agtgatgaac gaatgatgga agctagtaag gctgtgggaa ttcaccactt tattatgacc
    14461 ttgccagatg gctatgatac catcttggat gacaccgtga ccttgtctgt aggacaaaaa
    14521 caactattga ctattgctcg tacccttctt aaggatgcac cgcttttgat tttggatgag
    14581 gcgacttctt ctgttgacac acggacagag gaattgatcc aaaaagccat ggaccgtttg
    14641 atggaaggac gcacatcctt tgtcattgcc caccgcttgt caaccatccg aaatgcagac
    14701 ttgatcttgg tcatgaaaga tggaaatatc atcgagcaag gcaactatga ggaactgatg
    14761 gcgcaaggtg gcttctacgc tgacttgtac aatagtcaat ttacagaaga tgaagcagaa
    14821 gaataaatca aaagaaggct tgacggcctt ctttttctta tttatactag tacacataga
    14881 aagagagaag tatgagtcag aaattataca atatgaaatt tgctgctgtc tacttagcct
    14941 tgattgcaaa agttgagcga aagggtggaa aggcagagtc agttcaccaa gtgaccagtt
    15001 ggttgacagg gtatgaagtg agtgatgttc ttgcttgtct ggatagggat gttacttacg
    15061 gagatttttt tagacaagca ccatattatg tccctgaacg aattgcaatt acagggaaga
    15121 tttgcggtgt ccgtattgag gaaattgatg atcctctgat gcaggaaata cgtcgcttgg
    15181 acaagctagt ggattggctt gccaagggga aaacatctca acaagttcta gaaaagtatg
    15241 agaagcataa atgaaaaatt atcaagaatg gtatcgaaat atcagctcca gactaactag
    15301 tcgtccaatt cttttattcc tattacgcag tttcaatcgt ttgatgacag tcgccatgcc
    15361 cctggtctat ctgatcttgc tagtcaccac ttacctgcaa ctaggacttg gtcagcaagt
    15421 tggggtttat gtgcttattc ctgcatcagg ttttgtggcc ttgtccctgt ttcgtaagaa
    15481 aatcaatcac ccgagacctt atgaaacttg gaatacctgt ccccttcttg ataaggatag
    15541 ttcgggacgg tcgatgccca gtcgccatgt cttttcggca actatcatct ccatggcctg
    15601 tctgcatgct agtctaccta ttggcttagt atgcttgaac ttttcagctt tgctggggtt
    15661 ggtgagggtt ttagggggtg ttcattatcc caaggatgtc ttggttggct atgcttgtgg
    15721 tctggtgtgg ggattccttt tcttcttatt ctgacatgta agttaagcta gtcctacaac
    15781 cacttactgc ttcaaattga ccacttgctt ttttgccctt gtattcctaa cttagctttg
    15841 atatagtaga gtcagaaagg agatgtgatg aagttacgaa ttgagattga cggcaattta
    15901 gaggagactg aaattgtcat caagaccccc actttgacag atgaaattgc agacttgcaa
    15961 cggctcttgc aagaatccaa gtctcctagg ttgatttttt acaaggggac gggtgaatat
    16021 tatctggact tgtcggaaat tctcttcttt gagacagaag gtagcaagat ttatgcccat
    16081 acccagaaaa atgcctacga agttcggctc aaactctatg agttagaggc tatccttcct
    16141 cgctatttta gtcgagtatc caagtcaacg atcgttaata ttcggcaaat ctattcggtg
    16201 gacaagtcct tttcaggaac gggcaccatt tccttttatc aaacccacaa ggaggttcat
    16261 gtgtcacggc attaccaatc cctcctaaaa gaaaatctaa gaaatatgag gtaagaacat
    16321 gaaaaagaaa gcatttggta ttgtgttgct tgtactagca gctttaatat tagtacaagg
    16381 aaattttgga atcccttctc taggagggca catttggccc ttgattggta ttgctttttt
    16441 tgcctaccaa tcagttggag ctttgttgcg tcgccactta acttcagcct cttttacagc
    16501 tctagtagcc ttaatgattg ctaaccactt ttatggcatt ttaccgattc caaaccagac
    16561 actaatctgg gcaggagttc taatcgttct cggagtaaat atgttgactc attctaacag
    16621 aacttggaat gggaaaaaat ggtggtatga tggtgaaaaa aacattctta tagataagga
    16681 agttgctttt gggacaggga ctttctacaa gcaagaccaa gaattggtag aagaccaagt
    16741 agaagttggt tttggcaatg caaaaatcta ctatgacaat gcagagatgt taggtgattt
    16801 tgcaacttta aatattgaag tagcttttgg taatgcaact gtctatgttc cgcaacactg
    16861 gcgtgtcgat ttgaaagtag aaacatcctt tggtgcagcc aaggcggacg ctcctgtagc
    16921 cccaaccagc aaaaccttga ttatccgtgg agatgtggct tttgggaagt tggaaattgt
    16981 ctacgctaaa taaaaaaatc ttcacttcaa ccatcaaaat aggcgtacta agagtaggaa
    17041 attgatgcct tgctctgatt tcagttctat ggttgttaga ctttaaaaaa tgaaatgctg
    17101 cctttaaaag ttgtatattt ttcgatattt tggcttttac gtttgatgta tctatgtact
    17161 acagcgtaga tgatgtagtg tcgaatgctt ttaaaaaacg aatgatattg gacagttttt
    17221 ttgcctttaa ttgctcagga accatgaaag tcagtacttg ggtttatgac aagggagaat
    17281 ggtattatgt aagttcttct ggttccatga ttgcgaatga ttgggtcaaa gacaatggca
    17341 agtagtatta tctggcttca tcaggtaaga tgcttcgcaa tacctacaca cctgatggtt
    17401 actacgttgg caacttaggt gcctggcaat aagaataata ctctttgaaa atctcttcaa
    17461 accacgtcaa cgtcgcctta tctacaacct caaaaccgtg ttttgagcag cctgcggcta
    17521 gctttctagt ttgctcttag tataagaagt ccttttcctt aaaggaagag gctttttact
    17581 tgcttttctg ctgcttcctc atttgtcctg aagccttttt tgtgttaaaa tgaatggtat
    17641 gaaagctaaa aaaatgtgga tggcaggctt ggctctgcta ggtatcggaa gccttgctct
    17701 tgctacgaaa aaagttgcag atgaccgtaa gctcatgaag actcaggaag agttgacaga
    17761 gattgtgcga gaccattttt ccgacatggg ggaaattgcg accctttatg ttcaagttta
    17821 cgaaagcagt ctggagagct tggttggtgg cgtcattttt gaggatggcc gtcattatac
    17881 ctttgtctat gaaaatgaag acctagtcta tgaggaggaa gtcttatgat acagccagca
    17941 agtttagaag aattagcatc tttagtggaa aaagcgggca agaaggtctt cctttttgtg
    18001 gcagactggt gtggcgattg tcgttatatt tatcctgcct taccagagat tgaagagacc
    18061 aatccagagt tcacctttat tcgaatggac cgagatcagt atatggattt ggccaaactc
    18121 tgggatgttt acggaattcc tagccttgtt gttctagaaa aggacaagga aatcggtcgt
    18181 tttgtcaatc gcgaccgtaa aagtaaggag caaattaacg attttttagc aggattgaaa
    18241 taggagaaaa aggaaacaat gatttttacg tataacaaag aacatgtcgg tgatgtcctt
    18301 atggtcatcg tgaaaaatag cggagatgcc aaactgaatg tggaacgcaa aggcaaggta
    18361 gcccgtgttt tcctcaaaga aaatggggaa acagtagctt ggaacatttt tgaggtttcg
    18421 agcttgtttg aaattgcaga gcgcggtcaa gtctttttat cagatgagca agtcgctcgt
    18481 ttgaaccaag aattacaggc ggaaggtttt acagaagaaa ttgttaatga taaggaacct
    18541 aagtttgttg ttggtgaaat tgtcgagatg gtagctcatc cagacagtga ccacctcaac
    18601 atctgccaag ttgcagtcgc aagtgacaag atagtgcaaa tcgttgcagg agcacctaat
    18661 gcgcgtgttg ggttgaaaac cattgtggct cttcctggtg ccatgatgcc aaaagggaat
    18721 ttcattttcc caggcgaact tcgtggtgaa aagagttttg ggatgatgtg tagtcctcgt
    18781 gaattgcatt tgccaaatgc tccgcaaaaa cgtggggtgc ttgaattatc agaagaccaa
    18841 gttgtcggaa caccgttcga cccagcgaaa cactggactg cctaggaact tgtcagcatc
    18901 tgatagaagg aaataagatg gcaaaaaatg tagtgattac gggagcaacc tcaggaatcg
    18961 gtgaagcgat tgcgcgtgct tatctggagc agggtgatga tgtcgttcta acaggacgac
    19021 ggatagacag attagaaatc ctcaagtcgg agtttgcagt aagctttcca aatcaaaccg
    19081 tctggacttt tccactagat gtgacggata tggtcatggt gaagactgtt tgctctgata
    19141 ttctagaaac gatagggagg attgatatct tggtcaacaa cgccggactg gctcttgact
    19201 tggctcccta tcaagactat gaggagttgg atatgttgac catgttggat accaatgtta
    19261 aaggtctgat ggcggttact cactgtttct tgccagcaat gataaaagtc aatcaaggtc
    19321 atattatcaa tatggggtca accgcaggaa tctacgccta tgctggtgcc gctgtttact
    19381 cagctaccaa ggcagcggtt aagacctttt cggatggact gcgaattgat accatcgcaa
    19441 cggatatcaa ggtgacaacc attcagcctg ggattgtcga aacagatttc tcaactgttc
    19501 gttttcatgg tgataaagaa cgagctgcgt ccgtttacca aggaatagaa gccttgcaag
    19561 ctcaggatat tgcagacaca gtagtctatg tgaccagtca gcctcgccgt gttcagatta
    19621 cagatatgac cattatggcc aatcaacagg cgacaggttt catgattcat aaaaaataag
    19681 aaatttcctc gaaaagttac aaatttctgt aacttttttt gatttcctac gaatagataa
    19741 gtaggaggaa gaaaatatgt ataataaagt tatcatgatt gggcgtttaa cgtctacacc
    19801 agaattgcac aaaaccaaca atgacaagtc ggtagcgcga gcaactatcg ctgtcaaccg
    19861 tcgttacaaa gaccaaaacg gtgaacgtga agctgatttt gttaatatgg ttctatgggg
    19921 cagactagca gaaactttgg caagctacgc aaccaaaggt agtctcattt ccgttgatgg
    19981 agaattgcgt acccgtcgct ttgagaaaaa tggtcagatg aattatgtaa ccgaagtcct
    20041 tgtgacagga ttccaactct tggaaagtcg tgcccaacgt gctatgcgtg aaaataatgc
    20101 aggccaagat ttggcagatt tggtcttgga agaggaagaa ttgccatttt aatactcttc
    20161 gaaaatctct tcaaaccacg ttagctttat ccacaacatc aaagcaatgc tttgagcagc
    20221 ttgcggctag cttcctagtt tgctctttga ttttcattga gtataaacat taaaaagtct
    20281 gagttggtct caggcttttt atcttgagaa agtcagactt ttttcttgat tatttctgac
    20341 taagtgatac aatagaacta tgaattagca ctcaggtata aagagtgcta ataatatcta
    20401 tctcattatg gaggaaatca gatgttgaaa ccattagggg accgtgtggt cttaaaaata
    20461 gaagaaaaag aacaaaccgt tgggggcttt gttctcgcag gttcagccca agaaaaaacc
    20521 aaaacagccc aagttgtggc tactggacaa ggtgttcgta ccttgaacgg tgacttggtt
    20581 gctccaagtg ttaaaactgg agaccgtgtc ttagttgaag cccacgcagg tcttgatgtc
    20641 aaagatggcg atgaaaagta catcatcgta ggcgaagcta acatcttggc aatcattgaa
    20701 gaatagaagg agaaagtaag tatgtcaaaa gaaattaaat tttcatcaga tgcccgttca
    20761 gctatggtcc gtggtgtcga tatccttgca gacactgtta aagtaacctt gggaccaaaa
    20821 ggtcgcaatg tcgttcttga aaaatcattt ggctcaccat tgattaccaa tgacggtgtg
    20881 actattgcca aagaaattga attagaagac cattttgaaa atatgggtgc caaattggta
    20941 tcagaagtgg cttcaaaaac caatgatatc gcaggtgatg gaactacaac tgcaactgtt
    21001 ttgacccaag caatcgtccg tgaaggaatc aaaaacgtca cagcaggtgc aaatccaatc
    21061 ggtattcgtc gtgggattga aacagcagtt gccgcagcag ttgaagcttt gaaaaacaac
    21121 gccatccctg ttgccaataa agaagctatc gctcaagttg cagccgtatc ttctcgttct
    21181 gaaaaagttg gtgagtacat ctctgaagca atggaaaaag ttggcaaaga cggtgtcatc
    21241 accatcgaag agtcacgtgg tatggaaaca gagcttgaag tcgtagaagg aatgcagttt
    21301 gaccgtggtt acctttcaca gtacatggtg actgatagcg aaaaaatggt ggctgacctt
    21361 gaaaatccgt acattttgat tacagacaag aaaatttcca atatccaaga aatcttgcca
    21421 cttttggaaa gcattctcca aagcaatcgt ccactcttga ttattgcgga tgatgtggat
    21481 ggcgaggctc ttccaactct tgttttgaac aagattcgtg gaaccttcaa cgtagtagca
    21541 gtcaaggcac ctggttttgg tgaccgtcgc aaagccatgc ttgaagatat cgccatctta
    21601 acaggcggaa cagttatcac agaagacctt ggtcttgagt tgaaagatgc gacaattgaa
    21661 gctcttggtc aagcagcgag agtgaccgtg gacaaagata gcacggttat tgtagaaggt
    21721 gcaggaaatc ctgaagcgat ttctcaccgt gttgcggtta tcaagtctca aatcgaaact
    21781 acaacttctg aatttgaccg tgaaaaattg caagaacgct tggccaaatt gtcaggtggt
    21841 gtagcggtta ttaaggtcgg agccgcaact gaaactgagt tgaaagaaat gaaactccgc
    21901 attgaagatg ccctcaacgc tactcgtgca gctgttgaag aaggtattgt tgcaggtggt
    21961 ggaacagctc ttgccaatgt gattccagct gttgctacct tggaattgac aggagatgaa
    22021 gcaacaggac gtaatattgt tctccgtgct ttggaagaac ccgttcgtca aattgctcac
    22081 aatgcaggat ttgaaggatc tatcgttatc gatcgtttga aaaatgctga gcttggtata
    22141 ggattcaacg cagcaactgg cgagtgggtt aacatgattg atcaaggtat cattgatcca
    22201 gttaaagtga gtcgttcagc cctacaaaat gcagcatctg tagccagctt gattttgaca
    22261 acagaagcag tcgtagccaa taaaccagaa ccagtagccc cagctccagc aatggatcca
    22321 agtatgatgg gcgggatgat gtaagctttc tatagaaaac aacttataaa aaacacaaaa
    22381 ggagggaatg actaaccctt ctttttataa tattcacttc taaattgatt tgagctcttc
    22441 taacttatat gataaaataa gactagaaaa aggagaagaa catgatcgat gtagaagaaa
    22501 ttctgtgcaa gatgcccccc aatcagaaga ttaattatga ccgtgtcatg cagaaaatgg
    22561 tacaagcatg ggagaaaaat gagcagcggc caaccattct cgtgcatgtt tgctgtgccc
    22621 cttgtagtac ctatacacta gaatatttga ccaagtatgc agatgtgacc atctattttg
    22681 ccaattctaa tatccatccc aaagtagaat accataagcg ggtctatgtc atcaagaaat
    22741 ttgttagtga ttttaatgat cggacaggaa atacggttca gtacctagaa gctccctacg
    22801 aacccaatta ataccgaaaa ctagttaggg gactagagga ggagcccgaa ggtggcgacc
    22861 gttgcaaggt ttgttttgac taccgactgg ataaaacagc gcaagtggct atggacttgg
    22921 gctttgacta ctttggttca gccttgacca tcagtcctca taagaattct caaaccatca
    22981 atagcatcgg aatcgatgtg caaaaaattt acacgaccca ctatcttccc aacgatttca
    23041 agaaaaatca aggctacaaa cgttcagtag agatgtgtga ggagtatgat atctatcgtc
    23101 aatgttattg tggctgcgtc tatgcagccc aagcccagaa tattgacctg gttcaagtta
    23161 agaaggacgc cacagcatgc ttgttggata aggatgttga gaaagactat tctcatatca
    23221 aatttatagt agattgaaac tagaatagta cacctctact tctaaaacat tgttagaaat
    23281 cgatttgact gtccttattt cattttacta tactgttacg aaattagata tataaatgaa
    23341 aacttgcctc aaggtaggtt ttttgctagt agaaaagcga tagacagaaa ttgttggact
    23401 cttaaaaaaa tgaagttttg ctcaaaagag cttcttaaat taaaacgagc aattatcagt
    23461 tcaaatctgt ttcaaaagaa gaacggataa attaatcgat gctttgtttt tgagttagga
    23521 agttaagcat gccaaactga gtcgtaggaa taaatttctt tatagaaatg tgttgtaact
    23581 ctgctataat ggatttattc ctttttgtgt ttacacaatt tattttatac taccaaaaaa
    23641 acaaggtcag gattttgttc ctgacctttg acaactttac cgattcttta gttctacata
    23701 gcgcttgtac caaatgttta cataggcttc tgagaaagga ccacgtccat tgttaatcca
    23761 atcaacaaga attttgacat gttcttttaa aatatagtcc aagtcatcag aataattcat
    23821 tttgcgtttg tgacgctcgt actcttcaac gtccaagaga cgtttttccc catctgtaaa
    23881 aattttaaca tccaaatcgt aatcaatata cttcagtgct tcttcatcca gatagtaggg
    23941 gctagccata ttgcaatagt aagaagttcc attatcacga atcatggcaa tgatattaaa
    24001 ccaatatttc ttgtgaaagt aaacaatagc cggttctcga gtgacccaac gacgaccatc
    24061 actttcggta acaagtgtat gatcgttgac accaataatg gcgttttctg ttgtttttag
    24121 taccatggtg tcccgccaag ttcggtggag actcccatca tgcttataac tttgaattgt
    24181 aataaagtcg ccttcttttg gaagcttcat aactaaccaa ctttctacaa tttataagtt
    24241 tatcatttac tattgtacca taaaattacc taaaatctgt gaatttcact tggaaatatt
    24301 aaagatattc tctaagagcg cttgctatat ccgaaaaatc gtagcccttt cgtgctaaaa
    24361 cttgagttaa acgctgcttc agttcgtatc cttcatactt tcgagcatac ttagtatatt
    24421 gcttatcaag ttccttgaag atgagttctt gagtcgtttc ttgctcaact tggctatcta
    24481 agtcgtcaaa ggcaatttta gcatcagaat aagagaagcc cttgttagtc aagttctgga
    24541 taattttatc ttgcagggca cgagctggaa gttttccctc atattttttc aatagtttat
    24601 tagctacacg ttgagcaact tcagaaaaat caaattcttt caagttctct tctatagtag
    24661 attttgaaat ccctttttga gctagtttct gagtcagcac ataaggaccc ttgtctcctg
    24721 aaagttgatt ggtattgatg atagcataag cgtactgacc atcattaatc cacttatctt
    24781 ctttaagatt agcaataact tgagaaacga tgttttcatc aatatcgtat tttttcagat
    24841 attctctgac ttctttttca gtgcgtgctt taaaggataa gtggtagagg gccagattct
    24901 taccataaga aaattgagca aagtcttgaa tctctttcaa ttcctcttcg cttatcacct
    24961 tatctctcga taacataaaa cgaacaattg tatcttcggt gatatagcat ttgtcgccat
    25021 tatcaagctc catcagatag agtctttttt tcttttcaag ttttgtgatt ttcatagctc
    25081 tattataact caaaatgtga taagataggg gtatgaatct gaaagtgaaa caaaaaatac
    25141 cattaaaaat caaacgcatg ggaattaatg gtgagggaat cggcttttac caaaaaacat
    25201 tagtctttgt acctggagct ctcaaaggcg aagatatcta ttgtcagatt acttctatta
    25261 gacgcaactt tgttgaagca aaattactga aggtcaacaa gaagtctaaa tttcgaattg
    25321 tgccatcttg tactatttat aatgaatgcg gaggctgcca aatcatgcac ctgcattatg
    25381 ataagcagct ggagttcaag acggacttac ttcatcaagc gctgaaaaaa tttgctcctg
    25441 caggatatga aaattatgaa attcgtccaa ctattggaat gcaggaacca aaatattaca
    25501 gagctaagtt acaatttcag actcgaaaat ttaaaaatca ggtcaaggcg ggcttatatg
    25561 cacaaaactc tcactattta gtagagttga aagactgcct ggtacaagat aaggaaaccc
    25621 aagtgattgc taatcgctta gcagaattac ttacttatca ccagattcca atcacggatg
    25681 agagaaaagt tctaggtgtc cgtactatta tggtccgacg cgcgagaaag accggacagg
    25741 ttcagattat tattgttaca aaccgccagc ttaatttaac ccaactggta aaagagttgg
    25801 ttaaaggttt tccagaagtt gtgacagtag ctgttaatac aaatacagct aaaaccagtg
    25861 agatatatgg tgaaaagaca gagattatct ggggacaaga gagtattcaa gaaggtgtac
    25921 tcgattatga attttcacta tcccctcgag ctttctatca actaaatcct gaacaaacag
    25981 aagtccttta tagcgaggta gtaaaagcgc tggatgttag taaagaagac catttgattg
    26041 acgcttattg tggagttgga acaattggtt ttgcctttgc aaagaaagta aaaacactca
    26101 gaggtatgga tattattcca gaagctattg aagatgccaa gcgaaatgct aaaagaatgg
    26161 gatttgacaa tactcattat gaagctggaa cggcagaaga gattattcct cgttggtaca
    26221 aggaaggcta ccgagcagat gctttgattg ttgacccacc acgtacaggt ctggatgata
    26281 agttattaga tactattctt acttatgtac cagaaaaaat ggtttatatt tcttgtaatg
    26341 tttcgacctt ggctcgtgat ttggtacgct tagtagaagt ctatgatctt cattatatcc
    26401 agtcggtcga tatgttccca catacagctc gaactgaagc tgttgtaaaa ttaataaaaa
    26461 aagtttaaaa aagg
//
LOCUS       DAVHSO010000028        25349 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.028, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000028 DAVHSO010000000
VERSION     DAVHSO010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 25349)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25349)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25349
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.028"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(188..385)
                     /gene="blpI"
                     /locus_tag="VVR18_001166"
     CDS             complement(188..385)
                     /gene="blpI"
                     /locus_tag="VVR18_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpI"
                     /protein_id="HEU6032697.1"
                     /translation="MNTKMMEQFSVMDNEELEIVSGGRGNLGSAIGGCIGAVLLAAAT
                     GPITGGAATLICVGSGIMSSL"
     gene            667..1254
                     /locus_tag="VVR18_001167"
     CDS             667..1254
                     /locus_tag="VVR18_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase C39"
                     /protein_id="HEU6032698.1"
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKT
                     NKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQ
                     TKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
                     SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG"
     gene            1181..2824
                     /locus_tag="VVR18_001168"
     CDS             1181..2824
                     /locus_tag="VVR18_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="HEU6032699.1"
                     /translation="MVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVI
                     TYILQQVMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDA
                     NSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMFIIFSFMKPFE
                     KMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYS
                     ILQTSLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQT
                     KLQSAKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDTLTDIN
                     LTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHINY
                     LPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAG
                     LSGGQKQRIALARALLTKSPVLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRL
                     SIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK"
     gene            2835..4196
                     /locus_tag="VVR18_001169"
     CDS             2835..4196
                     /locus_tag="VVR18_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="HEU6032700.1"
                     /translation="MNSNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKE
                     ITVTSQGEIAPTSVIASIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTAL
                     ATQLQRLEKQKEGLGILKQSLEKATDLFSGEDEFSYHNTFMNFTKQSHDIELGISKTN
                     TEVSNQANLANSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTGNPHQSILNRY
                     LVASQGQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVL
                     RTQFLQTASQQQLTVENQLTELKVQLDQATQRLENNTLTAPSKGIVHLNSEFEGKNRI
                     PTGTEIAQIFPIITDTREILITYYVASDYLPLLDKGQTVRLKLEKIGNHGITIIGQLQ
                     TIDQTPTRTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTAKKTYFDYFKDKILT
                     HSD"
     gene            4253..4408
                     /gene="blpC"
                     /locus_tag="VVR18_001170"
     CDS             4253..4408
                     /gene="blpC"
                     /locus_tag="VVR18_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="HEU6032701.1"
                     /translation="MDKKQNLTSFQELTTTELNQITGGGWWEELLHETILSKFKITKA
                     LELPIQL"
     gene            complement(4450..5790)
                     /locus_tag="VVR18_001171"
     CDS             complement(4450..5790)
                     /locus_tag="VVR18_001171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU6032702.1"
                     /translation="MNIAWILLYALVINGLEIVIFFKVDGIGLTFDRIFKAFLLKFLL
                     GIIFTTFQFLAVSKYLSYFIEPLFGIGLSFLLLRGLPKKILIFYGLFPMILVELFYRG
                     VSYFVLPFLGQGIVDGDGNPIFLLIMIFVCFIVLVFLKWLDYDFTRLRREFLDTGFQK
                     SLTKINWAMGAYYLVMQSLSYLEYEQGIQSTTVRHLILVFYLLFFMGGIKKLDTYLKE
                     KLQEELNQEQTLRYRDMERYSRHIEELYKEIRSFRHDYTNLLTSLRLGIEEEDMEQIK
                     EIYDSVLRDSSQKLQDNKYDLGRLVNIRDRALKSLLAGKFIKAREKNIVFNVEVPEEI
                     QVEGMSLLDFLTIVSILCDNAIEASAEASQPHVSIAFLKNGAQETFIIENSIKEEGID
                     ISEIFSFGASSKGEERGVGLYTVMKIVESHPNTNLNTTCQNQVFRQVLTVIHAE"
     gene            complement(5804..6541)
                     /locus_tag="VVR18_001172"
     CDS             complement(5804..6541)
                     /locus_tag="VVR18_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032703.1"
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLL
                     AEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQDPYALIVFVTTHSEFMPLSFRYQ
                     VSALDYIDKALSTEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
                     LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKL
                     LFFPNGGSCLIARYKVREVSEAINNLH"
     gene            complement(6546..6884)
                     /locus_tag="VVR18_001173"
     CDS             complement(6546..6884)
                     /locus_tag="VVR18_001173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032704.1"
                     /translation="MKYMIIQTQKTVYKVNIDDIYYIQTHPTKAHTVQIVTEEASFNM
                     LQNLSNLENQCGETLMRCHRNCLVNLDKLKSIDFQERILFLGEEGQYAVKYARRRYRE
                     IRQKWLKQGE"
     gene            7160..7489
                     /locus_tag="VVR18_001174"
     CDS             7160..7489
                     /locus_tag="VVR18_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HEU6032705.1"
                     /translation="MTDTDPIKRAHTLITDLNKAYQACKQASADDVRFQEQLNSILGF
                     LAKAETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLIL
                     NENQRAN"
     gene            complement(7657..8706)
                     /locus_tag="VVR18_001175"
     CDS             complement(7657..8706)
                     /locus_tag="VVR18_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032706.1"
                     /translation="MKDLFLKRKQAFRKECLGYLRYVLNDHFVLFLLVLLGFLAYQYS
                     QLLQHFPENHWPILLFVGITSVLLLLWGGIATYMEAPDKLFLLVGEEEIKLHLKRQTG
                     ISLVFWLFVQTLFLLLFAPLFLAMGYGLPVFLLYVLLLGVGKYFHFRQKASKFFTETG
                     LDWDYLISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKAVQKVPGKIWQNL
                     YLRSYLRNGDLFALSLRLLLLSVLAQVFIEQAWIATAVVVLFNYLLLFQLLALYHAFD
                     YQYLTQLFPLDKGQKEKGLQEVVRGLTSFVLLVELVVGLITFQEKLALLALLGAGLVL
                     LVLYLPYQVKRQMQD"
     gene            complement(8703..9434)
                     /locus_tag="VVR18_001176"
     CDS             complement(8703..9434)
                     /locus_tag="VVR18_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032707.1"
                     /translation="MLEIKNLTGGYVHVPVLKDVSFTVESGQLVGLIGLNGAGKSTTI
                     NEIIGLLAPYSGSININGLTLQGDATSYRKQIGYIPETPSLYEELTLREHIETVAMAY
                     GIEQKVAFERVESLLKMFRLDQKLDWFPVHFSKGMKQKVMIICAFVVDPSLFIVDEPF
                     LGLDPLAISDLIQLLEVEKQKGKSILMSTHVLDSAEKMCDAFVILHKGEVRAKGNLLQ
                     LREAFDMPEASLNDIYLALTKEEDL"
     gene            9502..9912
                     /locus_tag="VVR18_001177"
     CDS             9502..9912
                     /locus_tag="VVR18_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEU6032708.1"
                     /translation="MSDCIFCKIIAGEIPASKVYEDEQVLAFLDISQVTLGHTLVVPK
                     EHYRNLLEMDATSASQLFAQVPKVAQKVMKVTKAAGMNIISNCEEVAGQTVFHTHVHL
                     VPRYSADDDLKIDFIAHEPDFDKLAQVAETIKNA"
     gene            9922..10209
                     /locus_tag="VVR18_001178"
     CDS             9922..10209
                     /locus_tag="VVR18_001178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032709.1"
                     /translation="MKLSNLLLFAGAAAGSYLVTKNRQTITDEVLNTTDRVQAIKDDV
                     DIIQNSLQIINQQKELIKEYQEDLTYKFKVLEKDIQTRLAVIKEMQGTEDK"
     gene            10371..10610
                     /locus_tag="VVR18_001179"
     CDS             10371..10610
                     /locus_tag="VVR18_001179"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032710.1"
                     /translation="MHHNLGNSYSIKIKKQTRKLGTDCSKHRFKVVDRTDEVSSKHCF
                     EVVDRTDEVSNHTHGKPTLTWFEEIFEEYYSPFHN"
     gene            complement(10944..12080)
                     /gene="dnaJ"
                     /locus_tag="VVR18_001180"
     CDS             complement(10944..12080)
                     /gene="dnaJ"
                     /locus_tag="VVR18_001180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HEU6032711.1"
                     /translation="MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAED
                     KYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGAGGFGGFNGAGGFGGFEDIFSSF
                     FGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
                     SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAH
                     SVHVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLN
                     LNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVN
                     VVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE"
     gene            complement(12424..12828)
                     /locus_tag="VVR18_001181"
     CDS             complement(12424..12828)
                     /locus_tag="VVR18_001181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanine-N7)-methyltransferase"
                     /protein_id="HEU6032712.1"
                     /translation="MDEEYLKNTRKVYNDFCNQADNYRTSKDFIDNIPIEYLARYREI
                     ILAEHDSCIKNDEAVRNFVTSVLLSAFVSALVSAMISLEIQTYKFVIPFIIGMIWTVV
                     VFLMINWNYIANTKKRQKYINISVLIGYLKSK"
     gene            complement(12839..14662)
                     /gene="dnaK"
                     /locus_tag="VVR18_001182"
     CDS             complement(12839..14662)
                     /gene="dnaK"
                     /locus_tag="VVR18_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HEU6032713.1"
                     /translation="MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKN
                     GEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAE
                     DYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDK
                     EEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKEN
                     GIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFD
                     DLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKS
                     VNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK
                     SQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
                     NGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNE
                     VDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQ
                     GLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK"
     gene            complement(15131..15655)
                     /gene="grpE"
                     /locus_tag="VVR18_001183"
     CDS             complement(15131..15655)
                     /gene="grpE"
                     /locus_tag="VVR18_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000046028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HEU6032714.1"
                     /translation="MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFEN
                     KYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKG
                     LGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKL
                     HDRILRPAMVVVYN"
     gene            complement(15682..16716)
                     /gene="hrcA"
                     /locus_tag="VVR18_001184"
     CDS             complement(15682..16716)
                     /gene="hrcA"
                     /locus_tag="VVR18_001184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcriptional repressor HrcA"
                     /protein_id="HEU6032715.1"
                     /translation="MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDM
                     AELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLE
                     DILQESANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
                     FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFE
                     HIFKEMFNENIVMAGKVNLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRVADG
                     QESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQVNVVNRVLTMKLTDFYR
                     YLSSNHYEVH"
     gene            complement(16880..17389)
                     /locus_tag="VVR18_001185"
     CDS             complement(16880..17389)
                     /locus_tag="VVR18_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001088691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HEU6032716.1"
                     /translation="MNSRVEFRIFTIVDLDKEEEYLHEMHLKGWRYRTSCFGLFYFEQ
                     GQPDDVIYRIYDSRFLKKYKHELQDFRDRGWELIGAGSCSILRKSSSDLLPEDQVYMS
                     KGLKWEVMRSRLRSCTATFLGGLVVCMSLFREDLSMSFFLIFVLYAFLISYLIYGYFR
                     LKRKYRVDE"
     gene            17996..20329
                     /locus_tag="VVR18_001186"
     CDS             17996..20329
                     /locus_tag="VVR18_001186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEU6032717.1"
                     /translation="MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTD
                     GRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDV
                     PFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY
                     TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLA
                     KRVLFLADRNILVDQTMAEDFRPFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGE
                     DGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKVIDYFSSATQIGMTATPKETKN
                     ASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIED
                     RYYGRKDFDKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVK
                     ENLDLVQEDYRYVMQVTGDNAEGKAQLDNFMDVNSNFPAIVTTSKLLTTGVNAKTCRL
                     IVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGEPVKVLE
                     TGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRK
                     NILGSYATLNDFITVWHTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLK
                     LAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILLNKYMDKGIGELESIETLKLP
                     EFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA"
     gene            20342..21805
                     /locus_tag="VVR18_001187"
     CDS             20342..21805
                     /locus_tag="VVR18_001187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEU6032718.1"
                     /translation="MSITSFVKRIQDITRNDAGVNGDAQRIEQMSWLLFLKIYDSREM
                     VWELEEDEYESIIPEELKWRNWAHAQNGERVLTGDELLDFVNNKLFKELKELEITSIM
                     PIRKTIVKSAFEDANNYMKNGVLLRQVINVIDEVDFNSPEDRHSFNDIYEKILKDIQN
                     AGNSGEFYTPRAATDFIAEVLNPKLGESMADLACGTGGFLTSTLNRLSSQRKTSEDTK
                     KYNTAVFGIEKKAFPHLLAVTNLFLHEIDDPKIVHGNTLEKNVREYTDDEKFDIIMMN
                     PPFGGSELETIKNNFPAELRSSETADLFMAVIMYRLKENGRVGVILPDGFLFGEGVKT
                     RLKQKLVDEFNLHTIIRLPHSVFAPYTGIHTNILFFDKTKKTEETWFYRLDMPDGYKN
                     FSKTKPMKSEHFNPVRDWWENREEILEGKFYKSKSFTPSELAELNYNLDQCGFPKEEE
                     EILNPFELIQNYQAERATLNHKIDNVLADILQLLEDK"
     gene            21805..23373
                     /locus_tag="VVR18_001188"
     CDS             21805..23373
                     /locus_tag="VVR18_001188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU6032719.1"
                     /translation="MTPEQLKASILQRAMEGKLVPQNPNDEPASELLKRIKAEKEKLI
                     SEGKIKRDKKETEIFRGDDGKHYGKFADGSTQEIDVPYDIPDTWEWVRFSTLVEIVRG
                     GSPRPIKDYLTSEVDGINWIKIGDTEKGEKYINNVKEKIKKSGLNKTRFVKKGTFLLT
                     NSMSFGRPYILNVDGAIHDGWLAISNYENSLNKDYLFYILSSNVVYSQFLSLISGAVV
                     KNLNSDKVASILIPLPPLSEQQRIIEAIESALEKVDEYAESYNRLEQLDKEFPDKLKK
                     SILQYAMQGKLVEQDPNDESVEVLLEKIRAEKQKLFEEGKIKKKDLDISIVSQGDDNS
                     YYGNKDETTSYPIYEIPEAWRYIKFASLVNFRIGKTPPRSEATFWGTEIPWVSISDMP
                     ISGYVTNTRESISKLALKSKKIDISPKGTLLMSFKLSIGKVAILDIPATHNEAIISIF
                     PYANKENIIRDYLMIFLPLISTLGDSKDAIKGKTLNSTSISELLIPISNHEEMKRIIS
                     KVDLLFQKVSQLFE"
     gene            complement(23321..23926)
                     /locus_tag="VVR18_001189"
     CDS             complement(23321..23926)
                     /locus_tag="VVR18_001189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012291636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU6032720.1"
                     /translation="MVKLTTCYFCDYGSYYGNIPMNWVVIKIKDIFSMNTGLSYKKGD
                     LSINNKGVRIIRGGNIKPLEFSLLDNDYYIDTQFISSEQVYLKHNQLITPVSTSLEHI
                     GKFARIDKDYDGVVAGGFIFQLTPFESSEIISKFLLFNLSSPLFYKQLKAITKLSGQA
                     LYNIPKTTLSELLIPLAPFEEQELITQKVEKLFEKVNQLWK"
     gene            complement(23937..24734)
                     /gene="psrA"
                     /locus_tag="VVR18_001190"
     CDS             complement(23937..24734)
                     /gene="psrA"
                     /locus_tag="VVR18_001190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type DNA invertase PsrA"
                     /protein_id="HEU6032721.1"
                     /translation="MKDFELHLKKAGLAENTVRSYLYGVRFFLENYELKMEDLFEYKG
                     YLLDNFKPKTVNLRLQGVNKYLAFIGHDDLKLKFVKVQQKPFLEDVISHADYLFLKRS
                     LKKDGILKWHFVVWFLGATGARVSELIKLKVEHVEIGYFDIYSKGGKIRRLYIPKKLR
                     NSCLSWLESENRRSGYLFLNKFNEPITARGVAQQLKNYADKYKMNPKVIYPHSFRHLF
                     AKNFLAKYNDIALLADLMGHESIETTRIYLRKTATEQQNIVDKIVNW"
     gene            complement(24791..>25349)
                     /locus_tag="VVR18_001191"
     CDS             complement(24791..>25349)
                     /locus_tag="VVR18_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU6032722.1"
                     /translation="EVPCEIPESWEWVRLNDITSYIQRGKSPKYSNIPIYPVIAQKCN
                     QWSGFSIDLARFIDPETVHSYQKERLLRDGDLMWNSTGLGTLGRLAIYHENKNPYAWA
                     VADSHVTVIRVLSGVINCHFIYNFLSSPIVQSVIEEKASGSTKQKELLTKTIKEYLIP
                     LPPLPEQSRIVDKIEQFFAHIDALI"
BASE COUNT         8166 a         5024 c         4554 g         7605 t
ORIGIN      
        1 ttttttattc ctaccaatcc atcaactaag taaagcatca acgattacat aaacgattga
       61 taatataatt aaaattttgc taactatctt attctcatca ttcttagata actttgatat
      121 tttgtaagta agtaaataag acagtaaatt aatagcgata ataatactat atttaagaat
      181 cataatctta caaagaggac ataattcctg aacctacaca aataagtgtt gctgctcccc
      241 cagttatcgg accagtcgca gcagctaata gtactgctcc aatacaacca ccgattgcag
      301 atcctaaatt gcctcttcct ccactaacta tttcgagttc ttcattatcc ataacagaaa
      361 attgttccat catttttgta ttcatgacaa atactccttt tttctttttt tatttttgtc
      421 ttgttgtaac tttgataagt ttagtatatc atcgtttttt aaaatttttc atccagatct
      481 tgaattgtca tcgaaacgtc ttgaattagc ttttttattt caagccacct ctaaatgttt
      541 aaaaaaaata atttctaatc acttttttac cattcaggaa gttttaatga ctattcaaga
      601 tttcataaaa tatgaactta gttttatgac ataatagacc tatccactat atgaaaggaa
      661 ttgccaatga cttcttataa acgtacattt gttcctcaaa tagatgcgag agactgtggt
      721 gtcgctgcct tagcctcgat tgctaaattc tatggttcag atttttctct agctcacttg
      781 agagaacttg caaagaccaa taaagaaggg acgactgctc ttggcattgt aaaagccgct
      841 gatgaaatgg gctttgaaac aagacctgtt caagcagata aaacgctctt tgacatgagt
      901 gatgtcccct atccatttat cgttcacgtt aacaaagaag gaaaactcca acattactat
      961 gttgtctatc aaacaaagaa agactatctg attattggtg atcctgaccc ttctgtaaaa
     1021 atcactaaaa tgtcaaaaga acgctttttc tatgaatgga ctggagtagc tatttttcta
     1081 gctaccaaac ccagctatca accccataaa gataaaaaga atggtctact aagcaagctt
     1141 ccttcctctg attttcaaac aaaaatctct cattgcttac attgttctct caagcttatt
     1201 ggtcactatt atcaatatag gtggttctta ctatctccaa ggaatcttgg atgaatacat
     1261 tccaaatcag atgaaatcaa ctttaggaat catctcagtt ggtctggtta tcacctatat
     1321 cctccaacaa gtcatgagct tttccagaga ttatctccta accgttctga gccagagatt
     1381 aagcattgat gtgattttat cctatattcg ccatattttt gaacttccca tgtctttctt
     1441 tgcgacacgt cgtacaggag aaatcatttc acggttcaca gatgctaact ctattataga
     1501 tgccttggct tctaccattc tttctctttt tctggatgtt tctattctga ttcttgtagg
     1561 gggcgtctta ctggcacaaa accctaatct cttcctcctt tctcttcttt ccattcctat
     1621 atacatgttc atcatctttt cttttatgaa accttttgaa aaaatgaacc atgatgtcat
     1681 gcaaagtaat tctatggtta gctctgccat tatcgaagat atcaacggga ttgaaactat
     1741 aaagtcgctc acgagtgaag aaaatcgcta tcaaaatata gacagcgaat ttgtagatta
     1801 tttggaaaaa tcctttaagc tcagtaaata ttctatttta caaacgagtt taaagcaggg
     1861 aacaaaatta gttctgaata tccttatcct atggtttggc gctcaattag tcatgtcgag
     1921 taaaatttct atcggtcagc tgattacctt taacacactt ttttcttact ttacaactcc
     1981 tatggaaaat attatcaacc tccaaaccaa actccaatct gcgaaggtcg ctaataaccg
     2041 tttgaacgaa gtctatctag tcgaatctga atttcaagtt caagaaaacc ctgtccattc
     2101 acattttttg atgggcgata ttgaatttga tgacctttct tataagtatg gttttggacg
     2161 agatacctta acagatatta atctcacgat taaacaagga gataaggtta gcctagttgg
     2221 agttagtggt tctggtaaaa caactttagc caaaatgatt gtcaatttct ttgaacccta
     2281 caaagggcat atttccatca atcatcagga tattaaaaac attgataaaa aagtcttgcg
     2341 ccgtcatatt aattacctac cccaacaagc ctatatcttt aatggctcta tcttggaaaa
     2401 tttaaccttg ggcggtaatc atatgattag ccaagaagat attctaagag cttgtgaatt
     2461 agctgaaatc cgtcaagaca ttgaaagaat gcctatgggc tatcaaactc agctctctga
     2521 tggagctggt ctatcaggag gacagaagca acgaatagcc ctcgctcgtg ctcttttaac
     2581 taaatctcct gttttaatac tagatgaagc tactagcggt cttgatgtct tgactgagaa
     2641 aaaagttata gataatctta tgtccctaac tgataaaacc attctctttg tagcccatcg
     2701 tctcagtata gccgaacgaa ccaaccgtgt cattgttctt gaccagggga aaatcattga
     2761 agttggtagc caccaagagt taatgcaggc gcaaggcttc taccatcatc tattcaataa
     2821 ataaggagaa tgtcatgaat tctaatcttt ttagaagcgt cgagttttat cagagacgtt
     2881 accataacta tgcgacagtg ttaattatac ctctttcatt actgtttact ttcatcttga
     2941 ttttctccct tgttgccaca aaagaaatta ctgttacttc ccaaggagaa atcgccccta
     3001 caagtgtcat tgcatccatt cagtcaacca gtgataatcc tatcctagct aatcatttag
     3061 tggcaaatca agtagttgag aaaggtgact tactcatcaa atactctgaa acaatggaag
     3121 agagtcagaa aactgcctta gcaactcaat tacaaagact tgagaagcaa aaagaaggac
     3181 ttggaatttt gaaacaaagc ttagaaaaag cgactgatct tttttctggc gaggatgagt
     3241 ttagctacca taataccttt atgaatttta ctaaacaatc ccatgatatt gaactcggta
     3301 tctcaaagac taacactgaa gtttcaaatc aagccaatct tgccaatagc agttcatcag
     3361 ccatcgaaca agaaattaca aaagttcaac aacaaattgg agaatatcaa gagctgagag
     3421 atgctatcat aaataacaga gctcgcttac caactggcaa tccgcaccag tcaattttaa
     3481 atcgttatct tgtagcctca caaggacaaa cacaaggaac ggcagaggag ccatttttat
     3541 ctcaaattaa tcaaagtatt gcaggtcttg aatcatctat cgcaagcctc aaaattcagc
     3601 aagctggtat cggaagtgta gcaacttatg ataatagttt agcaaccaaa attgaagtac
     3661 tccgcactca atttttacaa acagcttctc agcaacaact aaccgtggag aaccaattaa
     3721 cagaattaaa agtacaacta gatcaagcga cacagcgctt agaaaacaat accttaaccg
     3781 ctccaagtaa aggtatcgtt catctgaaca gcgaatttga aggtaaaaat agaattccaa
     3841 ctggtacaga aattgctcaa atattcccta tcatcacaga tacaagagaa atactaatca
     3901 cttactacgt agcttctgac tatctacctc tactagataa aggacaaact gtaagattaa
     3961 aactggagaa gattggaaat cacggcatta ccatcatcgg ccaacttcag acaattgatc
     4021 aaactcctac cagaacagag caaggcaatc tctttaaatt aaccgctctt gcaaaactat
     4081 ctaatgagga tagtaaactc atccaatatg gcttacaagg tcgcgtcact agtgtaactg
     4141 caaagaaaac atattttgat tatttcaaag ataaaatttt aacccattct gattaatttt
     4201 cagataacac tctataacta tttattatct tatcaaaaag gagaatcata acatggataa
     4261 gaaacaaaac ctaacttcat ttcaagaact aacaactacc gaactcaacc aaattacagg
     4321 tggaggatgg tgggaagaac tcttacatga aacaatttta agtaaattta aaatcacaaa
     4381 agcacttgag ctacctattc agctataaaa acaagaccga gaaacaagaa ctctcggtct
     4441 tgttttttat cattctgcat gtatcacagt aagtacctga cgaaagactt gattttggca
     4501 ggtagtattt agattggtat tgggatgact ttccacaatt ttcataacgg tatagagacc
     4561 aactcctctc tcctcccctt tagaacttgc tccaaaggag aagatttcag aaatatcgat
     4621 gccctcttct ttgatggagt tttcaatgat aaaagtctcc tgtgctccat tttttaaaaa
     4681 ggcgattgaa acatgaggtt gactggcctc tgcactagct tcaatagcat tgtcacaaag
     4741 gatagacaca atggttagaa aatcaagtag gctcatcccc tcaacctgaa tctcctcagg
     4801 aacttcaaca ttaaagacaa tgttcttttc tctagctttt ataaattttc cagctaggag
     4861 actcttgagg gcacggtcac gaatattcac caatctgccc aggtcatatt tattgtcctg
     4921 caatttctga ctggaatccc ttaagaccga gtcgtagatc tcttttatct gctccatatc
     4981 ctcctcttca atgcccaaac gtaagctggt taagaggtta gtgtagtcat ggcgaaaact
     5041 ccgaatttcc ttgtaaagtt cctctatatg ccgactatag cgttccatat ctctgtagcg
     5101 caaggtctgc tcttggttca gttcctcctg aagtttttcc ttcaaatagg tatccaattt
     5161 cttgataccc cccataaaaa agagtaggta aaacactagg atgagatggc gaacagtcgt
     5221 tgattgaata ccttgttcat attcaaggta agatagactt tgcatcacta gataataagc
     5281 ccccattgcc cagttaatct tagtaagaga cttttgaaaa cctgtatcta gaaactccct
     5341 tctcaatcta gtgaaatcat agtctaacca tttcaaaaag actaaaacta tgaagcaaac
     5401 gaatatcata atcaataaaa agataggatt gccatcccca tctacaattc cttgccccaa
     5461 aaatggaagc acaaaatagg aaacacctct gtaaaagagc tctactaata tcattgggaa
     5521 gagaccataa aaaataagga tttttttagg aagccctctt aacaataaga aagatagacc
     5581 tataccgaac aaaggttcta taaaatagga caaatattta cttacagcca aaaattgaaa
     5641 agtcgtaaaa atgatcccta gaagaaattt cagaagaaag gccttaaaaa ttctatcgaa
     5701 agtgagacca attccatcta ctttaaagaa aatgacaatt tctagtccat taataacaag
     5761 tgcatacaac aatatccaag caatgttcat aaactctcct agctcagtgt aagttattaa
     5821 tagcctcaga cacttccctg accttataac gcgcgatcag acaacttcca ccattgggaa
     5881 agaaaaggag tttttctttc ttatccaaat gcaccacatt tgcaggattg atgagaaaag
     5941 agcgatggca ctgcaagaga cggggttcct gcttgaaaac ctcctctaaa ctcgctgtaa
     6001 attccagcct gtctgtcttg gtatagagaa taacacgatg gggtcttggg gatgtttcga
     6061 gatagtaaac ctctttaaaa ggatactgaa attgggcaaa ttttgattta aagtaaaagc
     6121 aatcttccgc cagactttta ctatcttgac tattggcata gaggagggct gtctcgattc
     6181 gagattcaaa ctcctctgtc gaaagggcct tatcaatata gtccagagca gacacttggt
     6241 agcgaaagga caggggcata aactccgagt gagtcgtcac aaagacaatc agggcatagg
     6301 ggtcttgttc ccgaatcttt ctagccactt ccagcccctt catctcctca tttcgaatct
     6361 caatatccaa aaagaatagc tgatgggccc ccttctcatg cacctctgcc agcagttggt
     6421 ctggcttgcc aaatacctca aaagagctgg gagtgatatg atgttccttc aagagtttct
     6481 caatcgtcgt ttcaatccta gtctgttggg aaaaatcatc ctctaaaaca aatattctca
     6541 tctttttact ctccttgttt taaccatttt tgacgaattt ctctatagcg acgtctggca
     6601 tacttgacag cgtattgacc ttcttctccg agaaaaagga ttctttcttg aaaatcaatc
     6661 gattttaatt tatcaagatt aaccaaacaa tttcgatgac atctcatcaa ggtttcccca
     6721 cattggttct caagattact taaattttga agcatattaa aactagcttc ttctgtaaca
     6781 atctgtacgg tatgggcttt agttggatgt gtttggatat agtaaatatc gtcgatgttt
     6841 actttataga ctgttttctg cgtctgaata atcatatatt tcattggatt ctcctcctaa
     6901 gaaaagaata acagaaaagg tctagcccaa gcacacccaa tcctaaacag tctttgaaaa
     6961 ctcctaaaag gattattttc tacaacatca tgatgagctt acaactattt tatcataaaa
     7021 ttcactcagc gcaattcaag acatttcaat gacaattaaa gatttgaata aaaaaaaaga
     7081 attaaaagtg ataaactaac agtatcaaaa cacagttgcc agaagtaaga ctggcaccca
     7141 gattaaagga ggcattccca tgacagatac agaccccatc aaaagagctc atactttgat
     7201 tactgactta aacaaagcct accaagcatg caaacaggca agcgctgacg acgtccgctt
     7261 tcaggagcaa ttaaactcta ttcttggttt tctagccaag gctgaaacag tggataatcg
     7321 attcttgatt gaactagaaa aattttacca gacttccagt cttctcatgg gactcagcgc
     7381 tcttgatcca gatgctccaa ctcgcgccgc ttggcgggcc tatgaccgct tccactttga
     7441 ccaagtcaag accaagttaa tactcaatga aaatcaaaga gcaaactagg aagctagccg
     7501 caagctgtac ttgagtacgg taagacgacg ctgacgtggt ttgaagatat tttcgaagag
     7561 tataagtctc tacggaccaa ccattatcct gtagtaacaa aaaagaagct gagacaaact
     7621 gaactcaact tcttttttag tgtcgtatca gcaatgttag tcctgcatct gacgttttac
     7681 ctgataaggc aaatacaaga ctagtaaaac caaaccagct cctagtaagg ctagaagggc
     7741 tagtttttct tggaaggtaa tcaacccaac aactaattcc acaagtaaaa caaaactggt
     7801 caatcctcga actacctcct gtaagccttt ttccttttgc cccttgtcca gcggaaagag
     7861 ttgggtcaaa tactggtagt caaaggcatg atagagggcc agcaactgga agagcaagag
     7921 gtagttaaag agaactacca ctgctgtcgc aatccaagct tgctcgataa aaacctgcgc
     7981 cagtacggaa agtaagagaa gacgaagact gagagcaaag aggtcgccat ttcgcagata
     8041 agaacgcaga tagagatttt gccaaatctt cccaggcacc ttctgaacag cctttaagat
     8101 aaagtccaga taggcacgac gcttgacact gtttgaaatt cccttgacct gcgtaaagag
     8161 ggcaaagaaa cgaagcaaga cttgcttacg cttgctttct tgagaaataa gatagtccca
     8221 gtccagtcca gtttcagtaa aaaatttgct ggccttttga cgaaagtgga aatattttcc
     8281 tacccccaat aaaagcacat atagcagaaa aactggcaag ccataaccca ttgctaaaaa
     8341 taaaggcgca aataacagca agaaaagggt ctgtacaaag agccaaaaga ctagggaaat
     8401 gccagtttga cgcttgagat ggagcttgat ttcctcttct ccaactaaga gaaagagctt
     8461 gtctggagcc tccatatagg tggcaattcc tccccaaagt aagagtaaaa cagacgtaat
     8521 tcctacaaac aaaaggatag gccaatgatt ttcaggaaaa tgttgtaaga gttgactgta
     8581 ctggtaggct agaaagccca acaggacaag caggaataag acaaagtggt cattgagcac
     8641 atagcgcaga taaccaagac actccttacg aaaggcctgc tttctcttta aaaacaagtc
     8701 tttcatagat cctcctcttt ggtcagagcc aagtaaatat cattcaaact agcctcaggc
     8761 atatcaaagg cttcacgtag ttgcaggaga ttgcctttgg cacgcacctc tcccttgtga
     8821 agaatgacaa aggcatcaca catcttctcc gccgaatcca gcacgtgggt actcatgaga
     8881 atagacttgc ccttttgctt ctccacttcc aaaagctgaa tcaaatcaga aatagccagc
     8941 ggatcaagac caaggaaagg ctcatccacg atgaaaagac ttggatccac cacaaaagca
     9001 cagataatca tgaccttctg cttcatccct tttgaaaaat gaacagggaa ccagtctaat
     9061 ttctggtcca gacggaacat ctttaacaag gactctactc gttcgaaagc cactttttgc
     9121 tcaataccgt aagccatagc aaccgtttcg atatgctctc tgagggtcaa ttcctcatac
     9181 agactaggcg tctcaggaat gtagccaatc tgcttgcggt agctagtcgc atctccttgc
     9241 agagtcaggc cattgatatt gatggagcca ctataaggtg ccaacagacc gataatctca
     9301 ttgatcgtcg ttgatttccc agcaccattg agaccaatca aaccgaccaa ctgcccactt
     9361 tcaacagtaa aggacacatc tttcaaaaca ggaacatgaa catagccacc tgtcaggttt
     9421 ttaatttcta acatattttc tccaaatctg gtataatgta gctatattat atcaaaattc
     9481 agtacagtag aggtagattt tatgtcagat tgcatttttt gtaaaatcat cgcaggggaa
     9541 attcctgctt caaaagtata tgaagatgag caggtccttg cctttcttga tatctctcaa
     9601 gtaacactag gacacacctt ggtcgtgcca aaagaacact atcgcaatct tttggagatg
     9661 gatgctacga gcgccagcca actctttgcc caagtaccaa aagtagctca aaaagtcatg
     9721 aaagtcacta aggctgctgg tatgaatatc atttccaact gtgaagaagt cgctggtcaa
     9781 acagtttttc atactcacgt tcaccttgtg cctcgctaca gtgctgacga tgacctcaag
     9841 attgatttta tcgcccacga accagacttt gacaaacttg ctcaagtcgc tgaaaccatc
     9901 aaaaacgctt aaggagttgc tatgaaatta tccaacctac tgctatttgc aggagctgca
     9961 gccggaagtt atctggttac aaaaaatcgc caaaccatca cagatgaagt cttgaatacc
    10021 actgaccgcg ttcaagctat caaggacgat gtggatatta tccaaaacag cctgcaaatc
    10081 attaaccagc aaaaagaact tatcaaggaa taccaagaag acttgactta caagtttaag
    10141 gtcttggaaa aggatatcca gactagacta gctgtgataa aagaaatgca gggaactgaa
    10201 gataagtaaa aagagccccc cggctctttt ttaaaacgta aacaagttat agtgaattga
    10261 atttagaata gcacaccata gtttctaaag cattgttaga gattacttta aaatcctctt
    10321 atcaatttgt tcatattcta tttcaatcta ttatatatat cccatcaact atgcatcata
    10381 atttaggtaa ctcatactca ataaaaatca aaaagcaaac tagaaagcta ggcacagact
    10441 gctcaaaaca ccgttttaag gttgtggata gaactgacga agtcagctca aaacactgtt
    10501 ttgaggttgt ggatagaact gacgaagtca gtaaccatac ccatggcaag ccgacgctga
    10561 cgtggtttga agagattttc gaagagtatt attcaccatt tcacaactaa atcgaagact
    10621 ttctgccgta atgaaaacac ctgaaacagc ttggtttcag ctgtccggaa actttaaaac
    10681 ttaggttcaa agtttaggta tggaacttcg aaggaggtca ctaccgtccg tcattactta
    10741 ggaaagtctt aaaaaatcta taaagtaaaa agagcccgac agctcttttt gtttatactc
    10801 aatgaaaatc aaaaagcaaa ctaggaaact agccacgggc tgctcaaaac actgttttga
    10861 ggttgtagat acgactgacg aagtcagtca catatatacg acaagccgac gctgacgtgg
    10921 tttgaagaga ttttcaaaga gtattattct ccatcaaagg catctttaat atggtcaaag
    10981 aagccttttt tctttggatt tactttcaag tcaccagcag ccgcgaattc tttcaaggct
    11041 actttttggc ggtcgttcaa gcctgtcggt gttacgacat taacagtaac gtattggtca
    11101 ccaactgcac cgccacgaag gctcggtgcc cccttactac gtaggcggaa tttcttacca
    11161 gtctgagttc cctctggaat aaccaattca acatcaccgt gaacagttgg aatatctact
    11221 gtatcaccaa gagccgcttg gacaaagttg aggttgagat tgtagaagat agtcgttcct
    11281 tcacgttcaa acttgtcgct agcttctaca gaaactacta catacaagtc cccataaggt
    11341 ccaccgttaa agcctgcttc gccttgacca gcgaggcgaa tttgttgacc tgtttccaca
    11401 ccagcaggga ttttcacatg tacgctatga gcttgtttct catgacctgt tccatgacag
    11461 gttgtacatg gatatttgat ttcttttcct cgaccgtgac agacatcaca ggttacttgg
    11521 cgacgcatca taccaagagg agtctgcgta tcgacgttaa tgacaccagc gccatgacag
    11581 cgtccacaag tgactggact tgtccctggc ttagcaccag agccattaca tgtacgacag
    11641 ccagcttcac gatgatactt aacttccttc tcagttccga agatagcttc ttcaaaggtc
    11701 aaattgacac gatactggag atcatctcct tggcgaggag cgtttggatt gcgcgaagaa
    11761 ccgcctccgc cgaagaaact tgagaaaata tcctcaaaac caccgaagcc acctgcccca
    11821 ttgaaaccac cgaaaccacc agctccacca aaaccaccat tggcgcctgc agcaccatac
    11881 tggtcatagg cagcacgttt ttggtcgtca ctcaaagtct cataggcttc ttgaacttcc
    11941 ttgtacttgt cctcagcacc aggctccttg ttgatatctg ggtgatattt tttggaaagc
    12001 ttacgataag cctttttgat ttcgtctgcc gaagcgtttt tggatacccc cagacgatca
    12061 taaaattcag tattgttcat aattcaagat acaaagggcg tcaaacggac acagccatct
    12121 aggagttttg acgacggacg cttacgtcct agaaaaaact atctttttgg cacagtccgt
    12181 agcccgtgtt cagttacgaa cacccttatt cctttctatt gatgttctga atcgaaccac
    12241 catttaggtc ggattcaatt cctttctttt atatttagta agaaattctg aaacccgtgt
    12301 tcagttacga acactctttg ttcctttcta ttgatgagac aaaacccaaa caaataagat
    12361 tccgtccctt tttatcgaaa aacagaggct gggttgcaac ctctgcaaat aagtaaatta
    12421 actttatttt gattttaaat atcctataag tacagaaata tttatatatt tttgtctctt
    12481 cttagtattt gctatataat tccaattgat cataagaaat acaactactg tccaaatcat
    12541 accaattatg aacggtatta caaatttata tgtttgtatt tctaatgata tcatagctga
    12601 taccagcgcc gatacaaatg cagacaacaa tactgaggta acaaaattcc ttaccgcttc
    12661 atcatttttg atacaactat catgttcagc taatataatt tctctatatc tagctaaata
    12721 ttctattgga atattatcaa taaaatcttt tgatgttcta tagttatcag cttgattaca
    12781 aaaatcatta taaacttttc gtgtattttt tagatactct tcatccaata cactcgtctt
    12841 acttttccgt aaactctccg tctacgacgt catcgcctgc gtttcctgtt gcttgtgcgc
    12901 cttctgctcc ttcttgagct tgttgcgctg ctgcggcttg ttcgtagagt ttaacagcaa
    12961 gtccttgagc tttttcgttc aatgcttcaa gtttcgcttt catgtcgtcc aagttgttgt
    13021 cttcttgagc tttcttaagg tcatcaaggg cagcttgggc agcgtcacgt tctgcgtcga
    13081 agcctttacc ttcagtttcc ttgattgtct tttcagtcgc aaagattgct tggtctactt
    13141 cattacgaag gtctacttct tctttacgtt tcttatcggc ttcagcgttt gcttctgcat
    13201 ctttcatcat gcggtcgatt tcttcgtcag tcaaacctga gttcgattgg atgacaatag
    13261 tttgttcttt ttgagttcca aggtctttgg ccttaacaga cacgataccg ttcttgtcga
    13321 tgtcaaatgt tacttcgatt tgaggaattc cacgaggtgc agctgggata tcagtcaatt
    13381 ggaagcgtcc aagagtcttg ttatctgctg ccattgggcg ttcaccttga agaacgtgga
    13441 tatcaacggc tggttggttg tctgctgctg ttgagaagac ttgtgattta gatgttggga
    13501 ttgtagtgtt gcgatcgata agttttgtaa atactccacc cattgtttcg ataccaagtg
    13561 acaatggcgt tacatccaga aggacaacgt ccttgacatc accagtaatc acaccacctt
    13621 ggatagccgc acccatagca actacttcat cagggtttac tgatttgttt ggttctttac
    13681 cagtttcagc tttaacagct tcaacaacgg cagggatacg agttgaacca ccaacaagga
    13741 taacttcgtc gatttctgac aagctcaaac ctgcatctga aagggcttga cgaactggaa
    13801 cttttgtacg ttcaacaagg tcacgagtca aatcgtcaaa tttcgcacga gtcaaagtca
    13861 tttccaagtg aagaggtcca gcctcacctg cagtgataaa tggcaagctg atttgtgttg
    13921 aagttacacc agaaaggtct ttcttcgctt tttcagccgc atctttcaaa cgttgcattg
    13981 ccatcttgtc agtagacaag tcgataccgt tttctttctt gaattctgct accaagtggt
    14041 caatgatttt ttggtcaaag tcgtcaccac caagtttgtt gtcccctgca gttgacaata
    14101 cgtcgaagac accgtcaccc aattcaagga tagagacgtc gaatgtacca ccaccaaggt
    14161 caaataccaa gattttttct tctttgtcag tcttgtccaa accataagca agagctgctg
    14221 cagttggttc gttaacaata cgttctactt caagaccagc aattttacca gcgtcttttg
    14281 ttgcttgacg ttgagcgtcg ttgaagtaag ccggaactgt gataacagct ttggttactt
    14341 tctcaccaag gtagtcttca gcgtagcctt tcaagtattg aaggatcata gctgagattt
    14401 cttgtggagt gtattctttt ccatttgcag aaactttttc agaagttccc atcttagatt
    14461 tgatagagat aactgtatct gggtttgtga ctgcttgacg ttttgcagca tcaccaacga
    14521 tgatttctcc gtttttgaat gagactacag atggagttgt gcggtttcct tctgggtttg
    14581 cgatgatttt gctttcagtt ccttcaagaa ctgcaactgc tgagtttgtt gtacctaagt
    14641 caataccgat aattttagac atgtgttttt ctccttgtta gttaattttc tatttttctt
    14701 tttgatactc ttcttaagtg gcgacgccgt cagagcttga cttcgtcaat ctctttgact
    14761 aaactttgag cctaaggtct caaaatttgc gcaaatagcg ccacggcgaa gagtatcgtc
    14821 tttggttcgc ttcgctcact attacaaagc caaacatatt ttatctttct tcatagttta
    14881 ttgtcgtttc ggacaagttt tctattatgt aaattgcgac acgaggagtc gaaatcgatt
    14941 ttatttcgac gacgagttag taaggaagct agacaaacgc catagcgatt gccgttttct
    15001 gacgagttgc tttagctacc gtcagaattg ccgaatcgaa cacgccctaa gctctgagta
    15061 aaaaagatag attttcttgt gttcatcgaa cacttcgtca atctcctatt tttactgcgg
    15121 gctttgtatc ttagttatac accactacca ttgctgggcg taggatgcgg tcatggagtt
    15181 tgtagccttt ttgaaagact tgggcgatgg tatctactgg gtgttcatcg tctgctggga
    15241 gagtttggat ggccatatgg tagttatggt caaattcgcc atctgctgcg atttcttcaa
    15301 ttccttcttc tttcaaagcg tgaatcaagc tttcttgcac catccccaag cccttcttca
    15361 catcatctgt caaaccttca actgcaagtg cacgctcaag gttgtcaaga gatggtaaga
    15421 ttgcttttgc caagtcctgg ctacgataac gttgcaagtt ttgacgttct tcattggcac
    15481 ggcgttggat attttgcatt tctgcatgag cgcgaagata tttgttttcg aactcatctg
    15541 cacgttcatt tgccaagtcc aactcagact tttcaggagt tgtttcttca gctgtttcca
    15601 caacttcctc ttcttgaact tcttctactt cttcattttt tatatcttgg gccatgttcg
    15661 cctcctttaa tgatttcaat cttaatgtac ttcgtaatga ttactgctga ggtagcggta
    15721 aaaatctgtc aacttcatgg tcaaaacacg gttgaccaca ttgacttgat tgattagctg
    15781 ttggtaatcc agattaactg gaccgataat ggctagaatt ccaactcccc gataaggaat
    15841 gaggaactta ctactaatca ccgctaggtc agctaaacag gactcttgac cgtctgcaac
    15901 acgaacattt tgcatctgat cctcacgcaa cccctcacga atctccaagg ccaccttttg
    15961 cggttggtca aagaactgat aggctgctag attggcaaaa ttcaagagat tgaccttgcc
    16021 cgccatcaca atgttttcgt tgaacatttc cttaaagatg tgttcaaaga gatcgatgac
    16081 attatccgtt gttgtaaagt aacgctggat aatctgcgga atctccgtcc gaatcttgta
    16141 gtgaatatct aaaacggtgt gaccgaggaa acgttcctga atgatgctct tcagtttcag
    16201 caaatcctcc tgcaagaagt tccttggaat cagaaactga ctagtaaccg ttcgcgactc
    16261 gtctagggta aataccgcca aggctgtatg ttgccccaaa acaacgatat caaaggctgt
    16321 caaacgttgc ctgctcggct caacatccag tgccactacc gtacagccac tcaggtctgt
    16381 tagcaagtta gcagactctt gcagaatatc ctccaatttg aagaattcct gatcaaaggc
    16441 tttgacaatc tcatatacct cattttcagc cagtcggtca aaatccagtg agtgtttcac
    16501 atagtactga aaaccagcaa cacttggcat ccgaccgctt gaagtatgag ccttctcaag
    16561 caacccttgt ttttctagtt ccgccatgtc attacgaatg gttgcactgc tagagttaat
    16621 agactcttgc aaggcttttg atccgacagg ttcgtgcgtt ttggtaaaga tgtcaataat
    16681 cagatttaaa atatcctgct gacgctctgt aaccatctca tcactcctct ctgtctgatc
    16741 aattagcact caatgcatcc aagtgctaac tcatgattct attatacacc cttagaagag
    16801 aatgtcaaga caaaaactca aaaaattagc actcttttat caagagtgct aaaaatcaat
    16861 ctgaagacct agaaccttgc tattcatcta ctcggtattt cctttttagt ctgaaataac
    16921 cataaattag ataagaaatc agaaaagcat ataaaacaaa aataagaaag aaagacatag
    16981 aaagatcctc tctaaacaaa ctcatacaaa caacaagacc acctaagaaa gtagctgtac
    17041 aggaacgaag tctagatcgc ataacttccc atttgagccc cttactcata tagacttgat
    17101 cctctggaag taaatcagaa gacgatttac gaagaatcga acaagaacct gctcctatca
    17161 attcccaacc tctatctcta aaatcttgca gttcatgctt atatttttta agaaatctag
    17221 aatcatagat acggtagatg acatcgtctg gttgaccttg ctcaaaatag aacaaaccaa
    17281 aacaactcgt tctatacctc caacctttca aatgcatctc atgtaaatat tcttcttcct
    17341 tgtccaaatc aacaatggtg aaaatccgaa attctactct gctattcatt gtcttacccc
    17401 aaaattagaa aacatgcctg gcgttattta ttagataatt ctttccactt ttgactcaat
    17461 ctccaaaaaa tataagaaat ctgaatcgca aaaactatca ataaaaccca atctattatg
    17521 aaaatcaaaa atactcccca actgaaagaa ctacctccag tgacaaactt tgagaaaacc
    17581 ggtagtagag ctaaaaagag aagcaaaata ggaagcatcc gcattgttaa aatccgtttg
    17641 gcataaaaaa tctttattta aacgaaaata ttatggcaaa atttacgcca gtttttgaac
    17701 ggctgatgta gatattttat actttcaaaa tgtttaaatg tgattattta tttttgaaaa
    17761 atagctcacc agcccgactg aaagtgctta tagaatgata ataagtcgcc tgccgaaaac
    17821 agcgaaaaat agcggtgtta tgcggagata atctgacgcg atgcgaaagt atattgcata
    17881 cttattttca acaatttagc agagtatttt tataagtgtg atataataga agtataattt
    17941 gttctgatag tttattttat ggagaagtag atttttagaa tgcggagggt tcaatatggt
    18001 tgagtttata aagtctaaga aagaaatgag tgaggaggat attaaagcaa atttcatcac
    18061 tcctgctatt gtatccaaag gatggaaaaa tggtgagcat atcgcttacg aagaatactt
    18121 cactgatggt cgaattgaag ttagaggaga taaggctcgt cgtaaagaag gaaaaaaatc
    18181 agactattca ctgtattacc aatttggaac tcgaattgca attgttgagg caaaggataa
    18241 taaacacagc gttcgagcag gattacaaca agctattgaa tatggagaga ttttagatgt
    18301 tccatttgtt tattcttcga atggtgatgg ctttattgaa cacgaccgta tcacgagaga
    18361 agaacgtgag ctggagttag acgaattccc tactcgtgaa gaattatttt ctcgtatgac
    18421 gaaggaaaaa ggattgacgt acgaaattac agaagctatc tcaactccat actatacaga
    18481 cgccttctca atgaaaacgc cacgctatta tcagcaaata gctatcaacc gtactattga
    18541 aacagttgcc agaggacaaa aacgagtaat gtttgtgatg gcaacaggaa cggggaaaac
    18601 gttcatggct tttcaaatta ttcatcgcct tcgaaaagct ggtttggcta aacgagtttt
    18661 attcttagca gatagaaaca tcttagtaga ccaaacgatg gctgaagact ttaggccatt
    18721 cgaaaaggta atgacgaaaa ttacaccaaa acttttgact gctcctgaaa aattaaattc
    18781 ttttgaaatt tatctagggc tttatcagca actaactggt gaagatggaa ctgaaacaca
    18841 ttatcaaaaa tttgacaaag acttctttga tttaatcgta attgatgaag cacaccgtgg
    18901 ttcagctaag gaaaacagta actggcgtaa ggtaattgat tatttcagtt ctgcgacaca
    18961 gattgggatg accgctactc ctaaagaaac caagaatgct tccaatacgg aatactttgg
    19021 tgagccaatc tatacttata gtttaaaaca gggaatcgag gatggttttt tggctccata
    19081 tcgtgttatg agggttaatt tagatgtgga tgtggatggt tatcgtccag aaactggaaa
    19141 agttgatgct aacggacaat taatagaaga taggtactac ggcaggaaag attttgataa
    19201 aaccattgtc attgatgata gaacgcaaag agttgccaag tttgtttctg attatatgaa
    19261 gcaaaacaat gcacgatttg ataaaacaat tgttttttgt gttgatattg accatgccga
    19321 gcgaatgcgt gctgcacttg taaaagagaa tctagactta gtccaagaag actatcgtta
    19381 tgtcatgcaa gtaactggtg acaacgctga aggaaaagct caactggata actttatgga
    19441 tgtcaattct aattttcccg ctattgtaac aacgtctaaa ttattaacga caggagttaa
    19501 tgctaaaaca tgtcgtttga ttgttttaga ctctaatatc caatccatga ctgaatttaa
    19561 acaaattatt ggtcgtggca cacgtcttta tcctcaaaag gggaaagaat tttttacgat
    19621 tattgatttt cgaaatgtta ccaatttgtt tgctgaccct gattttgatg gtgagccagt
    19681 gaaggtgctg gaaacaggtg cgaaaacagt cagtggttct acgcccggtt tcgtagatga
    19741 ggaaggtgac ccagtagaaa aatatatcgt tacagacaag caggttacca ttcttaattc
    19801 tactgttcaa gtattggatg aaaacgggaa actgattacc gaaagcctga ccgactacac
    19861 tcggaagaat atcttaggta gctacgccac tttgaacgat tttatcacag tttggcatac
    19921 ggcggataaa aagaagctta tcttagacga actttataaa aaaggagttt atctagatgc
    19981 tattcgagag tcggagggaa tatcagaaca agaaatcgat gattttgatt tactcctaaa
    20041 acttgcctat ggtcaaaaag aattaaccaa aacggaacgt atcaataaac tcaaacaaag
    20101 cggatattta tataaatata gtgaggaagc gcgtgctgtt ttggaaattt tactgaacaa
    20161 atacatggat aaaggtattg gagaactcga aagcattgaa acattaaaac ttccagaatt
    20221 tcagatatat ggtggaacct tcaaaatcat caatacttat tttggagata aaaaacgata
    20281 tttacaagca attaaagaat tggagcaaga gctatttaca gtagcttaat gaaaggaaag
    20341 tatgtcaatt acatcatttg taaaaagaat tcaagatatc actcgaaacg atgctggtgt
    20401 taatggtgat gctcaacgta ttgagcaaat gtcttggtta ttattcttaa aaatttatga
    20461 tagccgtgaa atggtttggg aattagaaga agacgagtat gagtcaatta tcccagagga
    20521 attaaaatgg cgaaattggg ctcatgctca aaatggggaa cgggtattga caggcgatga
    20581 attacttgat tttgtcaata acaagttatt caaagagttg aaagagcttg aaataacttc
    20641 aattatgcct attcgaaaaa cgattgttaa atcagctttt gaagatgcga acaactatat
    20701 gaaaaatggc gtcttgttac gccaagtcat caatgttatt gatgaagttg atttcaatag
    20761 ccctgaagat cgtcattcgt ttaatgatat ttacgaaaaa attcttaaag atattcaaaa
    20821 tgctgggaac tcaggagaat tttatacgcc acgtgcagcg actgatttta ttgccgaagt
    20881 tcttaaccca aaacttggag aatcaatggc agaccttgct tgcggaacag gaggcttctt
    20941 gacttcgact ctgaaccgtt taagtagtca acgtaaaact agtgaagata ccaaaaaata
    21001 taatacagct gtttttggta ttgaaaagaa agcatttcct catcttttag cagttacaaa
    21061 tctgtttctt cacgaaattg atgaccctaa aattgttcat ggaaatactt tagagaaaaa
    21121 tgttcgtgaa tatacggatg atgaaaaatt tgacattatt atgatgaatc caccttttgg
    21181 agggtcagaa ttagaaacaa taaaaaataa ctttccagca gaattacgga gttctgaaac
    21241 agctgattta tttatggctg tcattatgta tcgtttgaaa gaaaatggtc gtgttggagt
    21301 tattttacct gatggttttc tatttggtga aggtgtaaaa actcgcttga aacaaaaact
    21361 ggtagatgag ttcaacttgc atacgattat taggttgcct catagtgtct ttgcaccgta
    21421 tacaggaatc catacgaaca ttcttttctt tgataaaaca aagaaaacag aagaaacttg
    21481 gttttatcgt ttagatatgc cagatggtta taaaaatttc tcgaaaacta agccgatgaa
    21541 gtcagaacac ttcaatcctg ttcgtgactg gtgggaaaat cgtgaagaga ttctggaagg
    21601 taagttctac aaatctaaat catttacacc tagtgaattg gctgagttga attataattt
    21661 agaccagtgt ggttttccaa aagaggaaga ggaaatctta aatccctttg agttgattca
    21721 gaattatcaa gcggaaagag caactttaaa tcataagatt gataatgtat tagctgatat
    21781 tttgcagttg ttggaggaca aataatgaca ccagaacaac ttaaggcaag tattctccaa
    21841 agagcgatgg aagggaaatt agtgccgcaa aatcccaatg acgaacctgc aagtgaatta
    21901 ttaaagagaa ttaaagctga aaaagaaaaa cttatcagtg aaggaaaaat caaacgagat
    21961 aaaaaggaaa ctgagatatt tcgtggtgat gatgggaaac attatgggaa gtttgctgat
    22021 ggaagtactc aagaaattga tgttccttat gatattcctg atacttggga gtgggtgagg
    22081 ttttctacat tggttgaaat tgtcagaggt ggctctccac gaccaatcaa agattatctt
    22141 acttctgaag tagatggaat aaattggata aaaataggtg atactgaaaa gggtgaaaag
    22201 tatataaata atgttaaaga aaaaatcaaa aaatcagggc ttaacaaaac tagatttgta
    22261 aaaaaaggta catttttgtt aactaattct atgagttttg gtagacctta tattttgaat
    22321 gttgatggtg caatacacga tggatggttg gctatttcga actatgaaaa ctcattaaat
    22381 aaagattacc tattctatat tctttcatca aatgtagttt attctcaatt tctatctcta
    22441 attagtggag ctgttgtgaa aaacttgaat agtgataaag ttgcttctat tcttatccct
    22501 ctccccccac tatccgaaca acaacgcata atagaagcaa tcgaatcagc tttagaaaaa
    22561 gtagatgaat atgctgaaag ttataataga ctagaacagc tagataaaga atttccagat
    22621 aaactaaaaa aatctattct tcaatatgct atgcaaggaa aattagttga acaagaccca
    22681 aatgatgaat cagtcgaagt tttacttgaa aaaatacgag cagaaaaaca aaaactcttt
    22741 gaagaaggca agattaaaaa gaaagatttg gacatttcta ttgtttccca aggagatgat
    22801 aactcttatt atgggaataa agacgaaaca acctcttatc ctatatatga aatcccagaa
    22861 gcatggagat atattaaatt tgctagccta gttaacttca gaataggaaa aactcctcca
    22921 cgcagtgaag ctactttttg gggaactgaa ataccttggg tatctatatc agatatgcct
    22981 atatctggtt atgtaactaa tacgagagaa tctatttcta aattagcatt aaaatcaaag
    23041 aaaatagaca tttcacctaa aggaacttta ttaatgagtt ttaaattatc tattggaaaa
    23101 gttgccatat tggatattcc tgccactcat aatgaagcca ttatatcgat attcccctat
    23161 gctaataaag aaaatattat cagagattac ttaatgatat ttttgccact tatctctact
    23221 ttaggtgatt caaaagatgc tatcaaaggg aaaacattaa atagtaccag tatctccgaa
    23281 ttattaatcc ctatttctaa tcatgaagag atgaaaagaa tcatttccaa agttgattta
    23341 ctttttcaaa aagtttctca actttttgag taataagttc ctgttcctca aaaggagcta
    23401 acggaattaa tagctcgctt agtgtagttt taggaatatt atataaagct tgacctgata
    23461 gtttagttat tgctttcaat tgtttataaa ataacggaga ggacaagtta aataatagaa
    23521 attttgaaat aatctctgaa ctttcgaatg gtgttaattg gaaaataaat ccaccagcca
    23581 caacaccatc atagtcttta tcgattcttg caaactttcc aatatgttct aaagaggttg
    23641 atacaggtgt tattagctga ttatgtttta aataaacttg ctcagaggag atgaattgtg
    23701 tatcaatgta gtaatcatta tccaacagag aaaattctaa aggcttaata ttaccaccac
    23761 gtataattct aacaccttta ttattaatgc ttaaatcgcc cttcttgtaa gaaagacctg
    23821 tattcattga aaaaatatct tttattttta taacaaccca attcataggt atattcccat
    23881 aataagagcc ataatcacaa aaatagcagg tagtcagttt gaccacctgt tattttttac
    23941 caattaacaa ttttatctac aatattttgt tgttcagtag ctgttttcct tagataaatt
    24001 cgagtagttt ctatactttc gtgtcccatc aaatctgcaa gcaaggcaat atcattatac
    24061 ttcgctaaaa aattcttagc aaataaatgc ctaaaagaat gagggtaaat tactttagga
    24121 ttcattttgt atttatcagc ataatttttt aactgttgag caactcctct tgctgtaatt
    24181 ggttcgttaa atttattcaa aaataaataa ccacttcgac gattttctga ttctaaccaa
    24241 ctaagacaac tatttcttaa ttttttagga atgtacagtc tacgaatttt accacctttt
    24301 gagtaaatgt caaaataacc gatttctaca tgctctactt ttagtttaat aagttcactt
    24361 acacgagccc cagttgcacc taaaaaccaa acgacaaaat gccattttaa aataccatct
    24421 tttttcaaac tacgtttaag aaaaaggtaa tcagcatggc taatgacatc ttctaaaaac
    24481 ggtttttgct gtactttgac aaattttaat ttcaaatcat catgaccaat aaaagccaga
    24541 tatttattta ctccttgtag tcgcaaattg acagttttag gtttaaaatt gtctaataaa
    24601 tatcctttgt attcaaataa atcttccatt ttgagttcgt aattctccaa gaaaaatcga
    24661 acaccataaa ggtacgaacg cacagtattt tcagctaaac cagctttctt caaatgtaat
    24721 tcaaaatctt tcaacgtaaa actcctatct tatgtttgat agaaattcca ccgcacgtaa
    24781 aactattata ctaaattagt gcgtcaatat gggcgaaaaa ttgttcgatt ttatcaacga
    24841 ttctggattg ttcaggaagg ggtgggaggg ggattaaata ttcttttata gttttcgtta
    24901 ataattcttt ttgttttgta ctacccgacg ctttttcttc aataactgac tgaacaatag
    24961 gagaggaaag aaaattatag atgaaatggc aattaataac ccccgataag actcttataa
    25021 ctgtaacatg gctatctgca acagcccagg cataaggatt tttattttca tggtaaatag
    25081 ctaatcgtcc taacgtacct agacctgttg aattccacat taaatcacca tctcttagta
    25141 atctttcttt ctggtaacta tgaactgttt cgggatcaat aaatcttgct aagtcaatag
    25201 aaaagccaga ccattgatta catttctgag caatcacagg gtatatagga atatttgaat
    25261 attttggaga cttccctctt tgaatgtagg aggttatatc gtttaacctc acccattccc
    25321 aactttctgg tatttcacaa ggtacttcc
//
LOCUS       DAVHSO010000029        24233 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.029, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000029 DAVHSO010000000
VERSION     DAVHSO010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 24233)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24233)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24233
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.029"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            59..1022
                     /locus_tag="VVR18_001192"
                     /pseudo
     CDS             59..1022
                     /locus_tag="VVR18_001192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000974692.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
     gene            1087..1323
                     /locus_tag="VVR18_001193"
     CDS             1087..1323
                     /locus_tag="VVR18_001193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032723.1"
                     /translation="MKIINGICRYIFDSKGFATIEVEIFLDSGDTGIGAAPRGSTTGH
                     YDIQYNEYYPRGNNFSPIPDGNIEFFRLYNICSG"
     gene            1421..1543
                     /locus_tag="VVR18_001194"
                     /pseudo
     CDS             1421..1543
                     /locus_tag="VVR18_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            1806..2234
                     /locus_tag="VVR18_001195"
     CDS             1806..2234
                     /locus_tag="VVR18_001195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032724.1"
                     /translation="MDGITKDFIKTAKLMKQLWPQLTDKEAIDEVKKYTNGKNTAIFT
                     EVEGDTIVGLALCSLRFDYVEGCKYSPVGFLEGIIVDEEYRLKDIAKNLCTKCEEWAK
                     NKGCKEFASDCTLTNTDSIRFHLNIGFQEANRIIHFKKKL"
     gene            2313..2900
                     /locus_tag="VVR18_001196"
     CDS             2313..2900
                     /locus_tag="VVR18_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Type 1 glutamine amidotransferase-like
                     domain-containing protein"
                     /protein_id="HEU6032725.1"
                     /translation="MGGNPPMKKYSIVDKIVLSTKIKRIIIFTVFRENWEPYMKKYTE
                     VFQSQFPNLNIDYFLLDTEQIDLDSYLDADIIIIGGGNTEKYIATYVNQEFKSYIDHM
                     LNKEAKIIGFSAGALLLGEKVYVSPNDNSDHQIKIKNGLGLFSQFLISVHYDSWNDKA
                     NKDRAEELVNVPIIPLNDHSCLVLDKLGNIIEKID"
     gene            3182..3434
                     /locus_tag="VVR18_001197"
                     /pseudo
     CDS             3182..3434
                     /locus_tag="VVR18_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335280.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside phosphotransferase"
     gene            3610..3863
                     /locus_tag="VVR18_001198"
                     /pseudo
     CDS             3610..3863
                     /locus_tag="VVR18_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558195.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            3991..5220
                     /locus_tag="VVR18_001199"
     CDS             3991..5220
                     /locus_tag="VVR18_001199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEU6032726.1"
                     /translation="MKISKRHLLNYSILIPYLLLSILGLIVVYSTTSAILIEEGKSAL
                     QLVRNQGIFWIVSLILIALIYKLRLDFLRNERLIILVILIEMLLLFLARFIGISVNGA
                     YGWISVAGVTIQPAEYLKIIIIWYLAHRFSKQQEEIATYDFQVLTQNQWLPRAFNDWR
                     FVLLVLIGSLGIFPDLGNATILVLVSLIMYTVSGIAYRWFSTILALVSATSVFVLTTI
                     SLIGVETFSKIPVFGYVAKRFSAFFNPFADRADAGHQLANSYFAMVNGGWFGLGLGNS
                     IEKRGYLPEAHTDFVFSIVIEEFGFVGASLILALLFFMILRIILVGIRAENPFNAMVA
                     LGVGGMMLVQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAVAFVLNIDASEKR
                     AKLYRELENQPMNLLLK"
     gene            5240..7936
                     /gene="ppc"
                     /locus_tag="VVR18_001200"
     CDS             5240..7936
                     /gene="ppc"
                     /locus_tag="VVR18_001200"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HEU6032727.1"
                     /translation="MSLQKLENYSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQ
                     LKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNID
                     QDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRK
                     YRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVP
                     HLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAETLKQSALTQCEVIMNY
                     YDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQAT
                     KTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYL
                     ASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAE
                     KSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTER
                     ARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYL
                     SSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIR
                     LTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITQKKSDTNTPNRYEAIMDQVVDRS
                     YDVYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWS
                     QSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNI
                     AFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYF
                     NILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG"
     misc_binding    8019..8236
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            8349..9353
                     /locus_tag="VVR18_001201"
     CDS             8349..9353
                     /locus_tag="VVR18_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU6032728.1"
                     /translation="MKNKRLIGIIAALAVLVAGSLIYSSMNKSEAQNNKDEKKITKIG
                     VLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGND
                     LVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNITGVSDHNPAQQQ
                     VELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTV
                     TVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHD
                     LGVATGKMIVQVLKGAKPADTPVNVFSTGKSVINKKIAQELGITIPESVLKEAGQVIE
                     "
     gene            9422..10288
                     /locus_tag="VVR18_001202"
     CDS             9422..10288
                     /locus_tag="VVR18_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032729.1"
                     /translation="MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVA
                     VTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGKIPTLLSGILVMTSCHSIMLLIM
                     GRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDN
                     PDMARSFGIHTGRMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLII
                     GEVIFKSLSLAERLVTIVVGSIAYQFLVWAVIALGFNTSYLRLYSALILAVCLMIPTF
                     KQTILKGAKLSK"
     gene            10285..11043
                     /locus_tag="VVR18_001203"
     CDS             10285..11043
                     /locus_tag="VVR18_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032730.1"
                     /translation="MTAIVELKNATKIVKNGFDEEKIILNDVSLEIFERDFITILGGN
                     GAGKSTLFNTIAGTLSLTSGTIRILGEDLTKFSPEKRAKYLSRVFQDPKMGTAPRMTV
                     AENLLIAKFRGEKRGLLPRRLTSYKDEFQVTIEKVGNGLEKHLNTPIEFLSGGQRQAL
                     SLLMATLKRPELLLLDEHTAALDPKTSVALMELTDEFVKKDQLTALMITHHMEDALKY
                     GNRLIVMKEGRIIQDLNQEEKAKMKISDYYQLFE"
     gene            11133..12893
                     /gene="dnaG"
                     /locus_tag="VVR18_001204"
     CDS             11133..12893
                     /gene="dnaG"
                     /locus_tag="VVR18_001204"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HEU6032731.1"
                     /translation="MVDKQVIEEIKNNANIVEVIGDVISLQKAGRNYLGLCPFHGEKT
                     PSFNVVEDKQFYHCFGCGRSGDVFKFIEEYQGVPFMEAVQILGQRVGIEVEKPLYSEQ
                     KPASPYQDLYDMHEDAAKFYHAILMTTTMGEEARNYLYQRGLTDEVLKHFWIGLAPSE
                     RNYLYQRLSDQYREEDLLDSGLFYLSDDNQFVDTFHNRIMFPLTNDQGKVIAFSGRIW
                     QKTDSQTSKYKNSRSTAIFNKSYELYHMDRAKKSSGKTSEIYLMEGFMDVIAAYRAGI
                     ENAVASMGTALSREHVEHLKRLTKKLVLVYDGDKAGQAAILKALDEIGDMPVQIVSMP
                     DNLDPDEYLQKNGPEDLAYLLTKTRISPIEFYIHQYKPENSENLQAQIEFIEKIAPLI
                     VQEKSIAAQNSYIHILADSLASFDYTQIEQIVNESRQVQRQNRMERISRPTPITMPVT
                     KQLSAIMRAEAHLLYRMMESPLVLNDYRLREDFAFATPEFQVLYDLLGQYGNLPPEVL
                     AEQTEEVERAWYQVLAQDLPAEISPQELSEVEMTRNKALLNQDNMRIKKKVQEASHVG
                     DTDTALEELERLISQKRRME"
     gene            12896..14005
                     /gene="rpoD"
                     /locus_tag="VVR18_001205"
     CDS             12896..14005
                     /gene="rpoD"
                     /locus_tag="VVR18_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HEU6032732.1"
                     /translation="MATKQKEVTTFDVQVAEFIRNHKQKGTATDDEINASLVIPFTLD
                     ADGIEDLLQRIQDAGISITDNEGNPSARVLSNEEEPELSDEDLIGSTSAKVNDPVRMY
                     LKEIGVVPLLTNEEEKELALAVEAGDIEAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRIVLREQLDEILDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRQPSRSKPLRDFIED"
     gene            14019..14348
                     /locus_tag="VVR18_001206"
     CDS             14019..14348
                     /locus_tag="VVR18_001206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEU6032733.1"
                     /translation="MAYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDG
                     DTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEVPEVTDTEVKLVWYPAWTVEKMSRYA
                     RIALGIK"
     gene            14463..15506
                     /gene="cpoA"
                     /locus_tag="VVR18_001207"
     CDS             14463..15506
                     /gene="cpoA"
                     /locus_tag="VVR18_001207"
                     /EC_number="2.4.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosylglucosyldiacylglycerol synthase"
                     /protein_id="HEU6032734.1"
                     /translation="MEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVT
                     ENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVK
                     RYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLR
                     TDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYK
                     KIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRD
                     LDLYKVILEGNYRATAGREEMKEAILEYQANPAALKDLKEKAKNISREYSEEHLLQIW
                     LDFYEKQAALGRK"
     gene            15522..16847
                     /locus_tag="VVR18_001208"
     CDS             15522..16847
                     /locus_tag="VVR18_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEU6032735.1"
                     /translation="MRIGLFTDTYFPQVSGVATSIRTLKTELEKQGHAVFIFTTTDKD
                     VNRYEDWQIIRIPSVPFFAFKDRRFAYRGFSKALEIAKQYQLDIIHTQTEFSLGLLGI
                     WIARELKIPVIHTYHTQYEDYVHYIAKGMLIRPSMVKYLVRGFLHDVDGVICPSEIVR
                     DLLSDYKVKVEKRVIPTGIELAKFERPEIKQENLKELRSKLGIQDGEKTLLSLSRISY
                     EKNIQAVLAAFADVLKEEDKVKLVVAGDGPYLNDLKEQAQNLEIQDSVIFTGMIAPSE
                     TSLYYKAADFFISASTSETQGLTYLESLASGTPVIAHGNPYLNNLISDKMFGTLYYGE
                     HDLAGAILEALIATPDMNEHTLSEKLYEISAENFGKRVHEFYLDAIISNNFQKDLAKD
                     DTVSQRIFKTVLYLQQQVVAVPVKGSRRMLKASKTQLISMRDYWKDHEE"
     gene            16878..17054
                     /locus_tag="VVR18_001209"
     CDS             16878..17054
                     /locus_tag="VVR18_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEU6032736.1"
                     /translation="MRSGRDKKIAGVCAGVAHYLDMDPTIVQVIWGVLTCCYGAGIVA
                     YIILWIIAPVATDY"
     gene            17113..17247
                     /locus_tag="VVR18_001210"
     CDS             17113..17247
                     /locus_tag="VVR18_001210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HEU6032737.1"
                     /translation="MAFGDNGNRKKTMFEKITLFIVIIMLVASLLGIFATAIGALSNL
                     "
     gene            17311..18621
                     /gene="obgE"
                     /locus_tag="VVR18_001211"
     CDS             17311..18621
                     /gene="obgE"
                     /locus_tag="VVR18_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HEU6032738.1"
                     /translation="MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGG
                     NVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAET
                     GKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
                     ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGL
                     IEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLME
                     RPQIIVANKMDMPESQENLEEFKKKLAENYDEFEELPAIFPISGLTKQGLATLLDATA
                     ELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNF
                     DRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD"
     gene            18631..18789
                     /locus_tag="VVR18_001212"
     CDS             18631..18789
                     /locus_tag="VVR18_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032739.1"
                     /translation="MGDKPISFRDADGNFVSAADVWNEKKLEELFNRLNPNRALRLAR
                     TKKENPSQ"
     gene            19876..21135
                     /locus_tag="VVR18_001213"
     CDS             19876..21135
                     /locus_tag="VVR18_001213"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEU6032740.1"
                     /translation="MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCV
                     PDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLL
                     GRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
                     DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIID
                     GVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMT
                     VSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVN
                     HVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITN
                     IEFILRGYSDIIEKLRNLGADIRLVED"
     gene            21151..21702
                     /locus_tag="VVR18_001214"
     CDS             21151..21702
                     /locus_tag="VVR18_001214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032741.1"
                     /translation="MNIWTKLAMFSFFETDRLYLRPFFFSDSQDFREIASNPENLQFI
                     FPTQASLEESQYALANYFMKSPLGVWAICDQKNQQMIGSIKFEKLDEIKKEAELGYFL
                     RKDAWAQGFMTEVVRKICQLSFEEFGLKQLSIITHLENEASQRVALKSGFSLFRQFKG
                     SDRYTRKMRDYLEFRYVKGEFNE"
     gene            21695..22972
                     /locus_tag="VVR18_001215"
     CDS             21695..22972
                     /locus_tag="VVR18_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEU6032742.1"
                     /translation="MSKHQEILSYLEELPVGKRVSVRSISNHLGVSDGTAYRAIKEAE
                     NRGIVETRPRSGTIRVKSQKVAIERLTFAEIAEVTSSEVLAGQEGLEREFSKFSIGAM
                     TEQNILSYLHDGGLLIVGDRTRIQLLALENENAVLVTGGFQVHDDVLKLANQKGIPVL
                     RSKHDTFTVATTINKALSNVQIKTDILTVEKLYRPSHEYGFLRETDTVKDYLDLVRKN
                     RSSRFPVINQHQVVVGVVTMRDAGDKSPSTTIDKVMSRSLFLVGLSTNIANVSQRMIA
                     EDFEMVPVVRSNQTLLGVVTRRDVMEKMSRSQVSALPTFSEQIGQKLSYHHDEVVITV
                     EPFMLEKNGVLANGVLAEILTHMTQDLVVNSGRNLIIEQMLIYFLQAVQIDDILRIQA
                     RIIHHTRRSAIIDYDIYHGHQIVSKANVTVKIN"
     gene            22988..23848
                     /locus_tag="VVR18_001216"
     CDS             22988..23848
                     /locus_tag="VVR18_001216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HEU6032743.1"
                     /translation="MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYV
                     RRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLG
                     GPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
                     MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAG
                     RGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVI
                     LTSQGEEGTY"
BASE COUNT         7610 a         4008 c         5387 g         7228 t
ORIGIN      
        1 tttgagataa ctattgcttc attttattca ataagattct aataaggagg ttaagtgaat
       61 ggctattatt aaaaaaattg ttgtactata tggtggcctt agcgaagaga gaggtgtcag
      121 aaaattctgc aaagtagatt agtaaaagtc tattaacatt ggggtacgat gtgatttcta
      181 tagatttatc tcaagactgt tcgtacgaga taggagaaat tgaaaaaagt gagcgcggat
      241 taaataaaca aaaagttgag attggttcgg gtattattga tgtttgtaga aaggttgata
      301 tagttttctt agcaactcat ggcggaatag gtgagaatgg gaaactacag gctatttttg
      361 atgtagaaaa aatagactat acaggaaatt cgtttcttag tacagctatt agcatggata
      421 aaaaattatc aaaaatagtg gctagttctg ttggaataaa atgtgcttcg aacttgatgg
      481 ttgatagaat tcaggcaaat gattttccta ttgttataaa gccaattaga agtggttcaa
      541 gtaaaggtat taagatactt caaaataaaa aacaatttga catttattat aaagagcatc
      601 ctgaacttgg ttcattcttt gtagaaaagt atattaaggg gagagaattt tcggtaggta
      661 ttttaggtga aactgtttta ccggttattg aaataaaagt aaaaaatggt ttttatgatt
      721 ataataacaa gtacactgtt ggtgcagctg aagaagtcgt tcccgcaaaa atatctgaaa
      781 agttaactca taccttacaa aaatccgcat ataaaataca taaggctctt ggatttaatg
      841 tttattcacg tactgatttt attgtagatg agaaggggga tgtatatttt attgaatcaa
      901 atagtttacc aggtatgact aaaacaagtt tattaccaca ggaagcgaaa gcagctggta
      961 tagatttccc aaacctatgt gaacgtatta ttgagctgag tagggaaatt agatctcaat
     1021 agaaaataaa atcgacgaca tttataaaaa agtaattttc aatgataaaa aagaaagtgg
     1081 aagcctatga aaataattaa tggtatttgc agatatatct ttgattcaaa agggttcgca
     1141 acaattgaag tagagatttt tcttgatagt ggagatactg gaattggtgc tgctccacga
     1201 gggtctacaa ctgggcatta tgatattcaa tataacgagt attatcctag aggaaacaac
     1261 tttagtccaa taccagatgg aaatatagaa tttttcaggc tctataatat ttgtagtggg
     1321 taaatcccct atggatatta tggagcctat tttgggtaga aaaaaagtcc cataagatct
     1381 ataatgaaaa gcgacaaaac aactcattag aaagaatcat atggaacaat tacattttat
     1441 cacaaaatta ctagacatta aagaccctaa tatccagatt ttagacatca tcaataagga
     1501 tacacacaag gaaatcatcg ccaaactgga ctacgacgca ccatgttgag gcagtatcac
     1561 tgcttgtaca agctgaggca tcagcgaagt agaagtaaat gatctcccat acgataggac
     1621 tcgtagaatg aggagggaaa ccgacgaaat gataaggtaa gtccgaaccg ctgagtgcgt
     1681 ggctctgctc ttccgatctg agacagtcga aaagtagaag gggatggtat tggtatcaat
     1741 caatgagtaa caaagtatca gcatgattcg aaacatttac ttgtaatttg cggaggaaca
     1801 tcaatatgga tggaataaca aaagatttta taaaaacggc taaactaatg aaacaattat
     1861 ggccccaatt gaccgataaa gaagctattg atgaagtaaa aaaatatacg aatggcaaaa
     1921 atactgcaat ctttactgaa gttgaaggtg acacaattgt aggtctagca ctatgttcac
     1981 tcagatttga ttatgttgaa ggttgtaaat atagtcctgt tggattctta gaagggatta
     2041 ttgttgacga ggaatatcgt ttaaaggata ttgctaaaaa tctctgtaca aaatgtgagg
     2101 aatgggcgaa aaataaagga tgtaaggaat ttgcaagtga ctgtacttta acgaatacgg
     2161 attctataag atttcatctc aatattggat ttcaggaggc aaatagaatt attcatttta
     2221 agaaaaaatt ataatttaga aacgtgaata aacttgttta aactttatgt atctttagaa
     2281 agtgtgttaa cttgaaagaa caaatttttt tgatgggtgg gaatccccca atgaagaaat
     2341 atagtattgt tgataaaatt gtattatcaa ccaagattaa aagaattatc atttttacag
     2401 tttttcgaga aaattgggaa ccgtacatga aaaagtacac ggaagttttt caaagtcaat
     2461 ttcctaatct aaacattgat tactttctcc tggacactga gcagattgat cttgatagct
     2521 atctagatgc tgacataatt atcatcggtg gtggaaatac ggaaaaatat attgctactt
     2581 atgttaatca ggagttcaaa agttatatcg atcatatgct taataaagag gcaaaaatta
     2641 taggattttc tgcaggagcc ctactattag gagaaaaagt ctatgtctca cctaatgata
     2701 attcagatca tcagataaag ataaaaaatg gattaggact ctttagtcag tttttaatta
     2761 gtgtccatta tgattcctgg aatgataaag caaataagga tagagctgaa gaactcgtta
     2821 atgttcccat aattccacta aatgatcatt cttgtcttgt attggataaa cttggaaaca
     2881 tcatagagaa aattgactaa ctttcataat gtaaaaatgg atctaggaaa taaaagtgta
     2941 gacgaactgg ataggttact agtgaaaact gcaaaaagtg ttgtaaagtg aatcggagtg
     3001 tgcttgatgg attttagtag taagatagcc ataaataaag gctggtcaga tgataaaaaa
     3061 tattgtgtga cagatcaaaa tcagtaaaaa tatttcttgc gtgtttctga taagtcgaag
     3121 ttagattata aaaaaatttg aatttgatat gatggagaaa gtagcttctc ttggagttcc
     3181 gatgtgtaaa ccaattagca ttgaactctg cgatgacgaa gtacattctt tacacgaatg
     3241 gatggataga cggaagagat gcaatagata gcattttaac ttattcagaa aaccaacaat
     3301 acacatatgg tgtagaagca ggaaagatac ttagaaagat tcatacaatt cctgctacag
     3361 aagtttgtga agattgggaa atctttttta atctaaaaat tgatgataaa atctccaacg
     3421 aaatgatatg gtaagtccga aacgctcagt gtgtaagctt gttgctaaaa gcgtaaaaac
     3481 cttggaacga aaggaataat agacttcctg cgaaacaaaa atacaataca ataaaactat
     3541 ggatgatgaa gcaagtaaac aattaagcga tagccgtttc aagagccttg taggtgttca
     3601 gcgcacgaga tgttagctgt gttaaaaaca gcttatcaac gcaacgtaaa cgcgcaaaag
     3661 gtggacgaaa aaccaaatta agcctagacg atctcctcat ggtaactatt caatacatgc
     3721 gagaatagcc cacttatgaa caaattgcgg ctgattttgg cattcacgaa agcaacataa
     3781 ttagtcggag ccaatgggtt gaagtaactc ttgttcaaaa tggttttacg atttcaaatt
     3841 ctgccctaat tatgaaaaac agtaaaattc gaaggattgt aaggtaagag tttttttctt
     3901 tctgaaaaaa tggtataata gcaatcaaaa ctagaaaata aaacggaatt tggaacagat
     3961 ttgtctgtat cctagtagag tggtgatact atgaagatta gtaagaggca cttattaaat
     4021 tattccatct tgattcccta cttgctttta tctattttgg gcttgattgt ggtctattcg
     4081 accaccagtg ctattttaat tgaagaaggc aagagcgcct tgcagttggt tcgaaaccaa
     4141 ggaatctttt ggattgttag tttgatactg attgccttaa tttataaatt gagactagat
     4201 tttttgagaa atgagcgact aatcatttta gttatattaa tagaaatgct tttattgttc
     4261 ttggctcgtt ttattggtat ttccgtaaac ggggcatacg gttggatttc ggttgcagga
     4321 gtaactattc agccagctga gtacttaaaa atcattatta tttggtattt agctcaccga
     4381 ttctccaaac agcaagaaga aatagctact tatgattttc aagttttgac tcaaaatcaa
     4441 tggcttcccc gtgcttttaa tgattggcga ttcgttctcc tagttctgat tggaagtttg
     4501 ggaattttcc ctgatttagg aaatgcgact attttagtct tggtttcctt gattatgtat
     4561 acagttagtg gaatcgctta tcgctggttt tcaaccattc tggcgctcgt atctgccact
     4621 tctgtctttg tcttgaccac tatcagccta atcggtgttg agaccttttc aaaaattcca
     4681 gtatttggct atgtagccaa gcgctttagt gcctttttta atccttttgc cgatcgtgct
     4741 gatgcaggtc accagttagc taattcttat tttgccatgg tcaatggtgg ttggtttggt
     4801 ctaggtcttg gaaactcgat tgaaaaacga ggttatttgc cagaagctca tacagacttt
     4861 gtcttttcta tcgtgattga agaatttggc tttgttggtg ccagtcttat tttagctctc
     4921 ttgtttttca tgattttgcg gattatcttg gtcggtatcc gagcggagaa tcctttcaat
     4981 gccatggttg cactcggtgt cggagggatg atgttggttc aggtatttgt caatatcgga
     5041 gggatttcgg gcttgattcc atctacagga gtgactttcc ctttcttatc ccagggtgga
     5101 aatagtcttc tagtcttatc agtggcagta gcctttgtct taaatattga tgccagtgaa
     5161 aaacgcgcta agttgtaccg agaattggaa aatcaaccaa tgaaccttct gttgaagtag
     5221 gataaagaaa ggatagttta tgtctcttca aaaattagaa aattatagta ataaaagtgt
     5281 tgtgcaagaa gaagtcttga ttctaacaga attactggaa gatattacta aaaatatgct
     5341 tgccccagag acctttgaaa aaataataca gttgaaagaa ttatcaacgc aggaagatta
     5401 tcaaggtcta aaccgtctag tgactagctt atcaaatgat gaaatggtct atatttcacg
     5461 ctatttctct atcttacctc ttttgattaa tatttcagag gatgtggatt tagcttatga
     5521 aatcaatcat caaaataata ttgatcagga ctatttaggt aaattatcta caacgattaa
     5581 attggtagca gaaaaggaaa atgccgttga gatcctagaa cacttgaatg ttgtccctgt
     5641 tttgacagcc catccaacac aagtgcaacg caaaagtatg ttggatttaa caaatcatat
     5701 tcatagtctt ttgcgtaaat accgtgatgt taagttgggg ttgatcaata aagataaatg
     5761 gtacaatgat ttgcgtcgtt acatcgaaat tatcatgcag acagacatga ttcgtgagaa
     5821 aaaattaaaa gtgactaacg aaatcacgaa tgctatggaa tattataaca gctccttttt
     5881 gaaagctgta cctcatttga cgacggagta taagcgctta gcgcaagcgc atggtctgaa
     5941 tttaaaacag gctaaaccaa tcaccatggg tatgtggata ggtggtgacc gtgatggaaa
     6001 tccatttgtt acagcagaga ccttgaagca gtctgcactc actcaatgtg aagtcatcat
     6061 gaactattat gataaaaaga tttaccaact ttatcgtgaa ttttctcttt caactagcat
     6121 tgtcaacgtc agcaagcaag tcagagaaat ggctcgtcaa tccaaggata actcgattta
     6181 ccgcgaaaaa gagctttacc gtcgtgcctt gtttgatatt caatcaaaaa ttcaggcaac
     6241 taaaacctat ctgattgagg atgaagaagt tgggactcgt tatgaaaccg ccaatgattt
     6301 ctacaaggat ttgattgcca ttcgagattc tctactagaa aataagggcg agtccttgat
     6361 ttcaggtgat tttgtggaat tattgcaggc agtagagata tttggttttt acctagcatc
     6421 aattgatatg cgacaagact ctagcgtcta tgaagcctgt gtggcagaac tcttgaaatc
     6481 agcaggaatt cattctcgtt atagcgagtt gagcgaagaa gaaaagtgtg accttctctt
     6541 gaaagaatta gaagaagatc cccgaattct ttctgcgact cacgcagaaa aatcagaatt
     6601 attagcaaaa gaactagcta tttttaagac ggctcgtgtt ttgaaagata agttgggaga
     6661 tgatgtcatc cgtcagacca tcatttcaca tgcaaccagc ctttctgata tgctagaatt
     6721 agctattctg ttaaaagaag taggactggt ggatacggaa agggcgcgtg ttcagattgt
     6781 tccccttttt gaaacaattg aagacttgga tcattcagag gaaacaatga gaaaatatct
     6841 ttctcttagc cttgccaaaa aatggattga ctcacgaaat aactaccaag aaatcatgct
     6901 tggctactct gacagtaata aagatggcgg ttacttgtca tcatgttgga ccctctacaa
     6961 ggctcaacaa caattgactg ctattggaga tgaatttggc gttaaggtta ccttcttcca
     7021 tggtcgtggt ggtactgtcg gtcgtggtgg tgggccaacc tatgaagcca ttacatctca
     7081 accgctcaag tctatcaagg atcgtatccg cttgacggag cagggtgaag taattgggaa
     7141 taaatacggt aacaaagacg ccgcttacta taaccttgaa atgctagtat cggcagctat
     7201 taaccgtatg attactcaga agaagagcga taccaatacc ccaaatcgtt atgaagccat
     7261 tatggatcaa gtagtggacc gtagttacga cgtctaccgt gatttggtct ttggtaatga
     7321 gcatttctat gattatttct tcgagtcaag tccaatcaag gctatttcaa gttttaatat
     7381 tggttctcgt ccagccgctc gtaagactat tactgaaatc ggtggattgc gtgccatccc
     7441 ttgggtattc tcatggtcac agagtcgtgt tatgttccct ggatggtacg gggttggttc
     7501 aagcttcaag gaatttatca ataaaaatcc agagaatatt gctatcttac gagatatgta
     7561 ccaaaattgg cctttcttcc aatcgcttct ttcaaatgtt gatatggttt tgtcaaaatc
     7621 aaatatgaat attgcttttg aatatgctaa actttgtgaa gacgagcaag ttaaggccat
     7681 ctatgagact attttaaatg aatggcaagt tactaagaac gttatcttgg ctattgaagg
     7741 acatgacgaa ctcttagctg acaatccata tctaaaagct agtctggatt accgtatgcc
     7801 ttactttaat attctcaact atattcagtt ggagttgatt aaacgccaac gtcgtggaga
     7861 attgtctagt gatcaagaac gattgattca tatcaccatc aacggaattg cgacaggatt
     7921 gcgtaattca ggttgataat tttcaagagt gaatgctaaa agtgaatatc aaaaaaattc
     7981 taatagacta ttgacaagta gtttaaaaat gatataattt aaccattcag aaaagtaatc
     8041 atacaaactt tttagagagt ctgtggtagc tgaaaacaga taagtggcga tgatgaaaat
     8101 tgggctgaat gctatttaga atttgaaatt ataaaaattc ggtaagcaca ccttacagtg
     8161 catctcgtta ttgcgagact gagcgatagg gaaattccct ataattgagg tggtaccgcg
     8221 catcgacgtc ctcacacaag ttttttgtgt gaggattttt ttgatggagg ttagtatgga
     8281 aagaaaacga tggcgtcgct tgtttagata agtgaaatat gttaaaggaa ataaaaagga
     8341 gaaacagaat gaaaaataaa cgtttaattg gaattattgc tgcattagca gtcttagtag
     8401 caggaagctt gatttattct tcaatgaata aatcagaagc tcagaataat aaggatgaga
     8461 agaaaataac taagattggt gtgcttcaat ttgtgagcca tccatccctt gatttgattt
     8521 ataaagggat ccaagatgga cttgcagaag aaggatataa agatgatcaa gttaaaattg
     8581 attttatgaa ctcagaaggt gaccaaagta aggttgcgac aatgagtaaa caattggttg
     8641 caaatgggaa tgaccttgtg gttggtatcg caacaccagc agcccaaggg ttggctagtg
     8701 caacaaaaga cctaccggtt atcatggccg ctattacaga cccaattggt gctaacttgg
     8761 ttaaagattt gaaaaaacca ggtggcaaca ttacaggggt atctgaccac aatccagctc
     8821 aacaacaagt tgaactcatc aaggctctga caccgaatgt gaaaacaatc ggagctcttt
     8881 actcaagtag cgaagacaat tcaaaaacac aggtcgaaga atttaaggct tatgctgaaa
     8941 aagcaggtct gacagtggaa acatttgcag ttccttcaac aaatgaaatt gcctcaactg
     9001 tcactgttat gactagcaag gtagatgcta tttgggttcc aattgataac accattgcat
     9061 caggatttcc aacggttgtc tctagcaatc aaagttctaa gaaaccaatt tatcccagtg
     9121 cgacagctat ggtagaagta ggtggtttgg catcagttgt aattgaccaa catgaccttg
     9181 gtgtggcaac aggtaaaatg attgtgcaag tcttgaaagg tgcaaaacca gccgataccc
     9241 cagtcaatgt cttttcaact ggtaagtcag tcatcaataa aaaaatagca caagaactag
     9301 gtattactat tcctgagtct gttctcaaag aagcaggaca agtcatcgaa taaataaggt
     9361 agggaggagg agactcttcc cattttttaa aaagatgaat atagaaagga ttaaataaaa
     9421 tatgattgtt tccattattt ctcaaggatt tgtctgggct attctaggtc tgggaatctt
     9481 tatgacattt aggattttaa actttccaga tatgacgaca gaaggttcct tccctcttgg
     9541 gggagctgtt gctgtcactt tgataaccaa aggcgtgaac ccatttttag cgacacttgt
     9601 tgctgtaggg gcaggttgtt tggctggaat ggcagcaggc cttctttata caaaagggaa
     9661 gatcccaacc ttgctctcag ggattttggt gatgacttct tgtcactcaa tcatgctctt
     9721 gattatggga cgtgcgaatt taggcctgct tggaaccaag caaattcagg atgttttgcc
     9781 ttttgattcg gatttgaatc aactcttgac aggtctcatc tttgtgagta ttgttattgc
     9841 tctcatgctc tttttcttgg acactaaact cggacaagcc tatattgcta caggggataa
     9901 tcctgatatg gctagaagtt tcgggattca tactggacgc atggagctca tgggcttggt
     9961 cttatcaaat ggtgtgattg cccttgcagg tgccctcatt gctcagcaag aaggttatgc
    10021 cgatgtgtct cgagggatcg gggttatcgt tgtggggctt gcaagtttga ttattggaga
    10081 agttattttc aagagtttga gcttggcaga gcgtttggtt actatcgttg taggttctat
    10141 cgcttatcaa tttttagtgt gggcagttat cgcacttggc tttaatacaa gttaccttcg
    10201 tttatacagt gccttgattt tagcagtctg cctcatgatt ccaacattta agcaaacaat
    10261 cttgaaagga gccaagttaa gcaaatgaca gcaattgtag aattaaaaaa tgcaaccaaa
    10321 atcgttaaaa atggctttga tgaagaaaag attattttaa atgatgtttc cttagaaatt
    10381 tttgaacggg actttatcac gattttgggc ggaaatggtg ctggaaaatc aaccctcttt
    10441 aacactatag cagggacctt atcactaact agtggaacta tccgtatttt aggtgaagat
    10501 ctcactaagt tttcacccga gaagcgtgcc aagtacctgt ctcgtgtctt ccaagatcca
    10561 aagatgggga cagctccccg tatgacggtc gctgaaaatc ttttaatcgc caagtttcgt
    10621 ggtgaaaagc gtggattgtt accacgacgc ttgactagct ataaggatga atttcaggta
    10681 accattgaaa aagtaggaaa tggtcttgag aaacacttga atacaccgat tgagttctta
    10741 tcaggtggac aaagacaggc tttgagtctc ttgatggcaa ccttgaagcg acctgaatta
    10801 ctcctgttag atgagcatac tgctgccctg gatccaaaga ctagtgttgc tttgatggaa
    10861 ttgacagatg aatttgttaa gaaagatcag ctaacagccc ttatgattac tcatcatatg
    10921 gaagatgctc tcaaatacgg caatcgcttg attgtcatga aagaaggacg gattatccaa
    10981 gatttaaacc aagaagaaaa agcaaaaatg aaaatctctg attattatca actctttgaa
    11041 taaagtaggg aaaatgagtg aaatggttta ctttttttct gaaataaagt atactatata
    11101 aagtaaacta tgataacatg gaggtattgt gtatggttga caaacaagtc attgaagaaa
    11161 tcaaaaacaa tgccaacatt gtggaagtca taggagatgt gatttcttta caaaaggcag
    11221 gacggaacta tctagggctc tgtccttttc atggtgaaaa aacaccttct ttcaacgttg
    11281 tagaggacaa gcagttttac cactgttttg gttgtggtcg ctcaggtgat gtctttaaat
    11341 tcatcgagga gtaccaaggg gttcccttta tggaggctgt ccaaatctta ggtcagcgtg
    11401 tcgggattga ggttgaaaaa ccgctttata gtgaacagaa gccagcctcg ccttaccaag
    11461 atctttatga tatgcacgaa gatgcggcta aattttacca tgctattctc atgacaacga
    11521 ctatgggcga agaggccaga aattaccttt atcagcgggg tttgacagat gaagtgctta
    11581 aacatttttg gattggttta gcaccttcag aacgaaacta tctctatcaa cgtttgtctg
    11641 atcagtatcg tgaagaggat ttactggatt caggcctgtt ttatctctcg gatgacaatc
    11701 aatttgtaga cacctttcac aatcgcatta tgtttcccct gacaaatgac caaggaaagg
    11761 tcattgcctt ctcaggtcgt atctggcaaa aaacggattc acaaacttct aagtataaaa
    11821 acagccgatc gactgcaatt tttaacaaaa gttacgaatt atatcatatg gatagggcaa
    11881 aaaaatcttc tggaaaaact agtgagattt acctgatgga aggattcatg gatgttattg
    11941 cagcctatcg ggctggaatc gaaaatgctg tggcgtcgat gggaacggcc ttgagtcgag
    12001 agcatgttga gcatctgaaa aggttaacca agaaattggt tcttgtttac gatggagata
    12061 aggctgggca agccgcgata ttgaaagcat tggatgaaat tggtgatatg cctgtgcaaa
    12121 tcgttagtat gcctgataac ttggatcctg atgagtatct acaaaaaaat ggtccagaag
    12181 acttggccta tctattaaca aaaactcgta ttagtccgat tgagttctac attcatcagt
    12241 acaaacctga aaacagtgaa aatctgcagg ctcagattga gtttattgaa aaaatagctc
    12301 ccttgattgt tcaagaaaag tccatcgctg ctcaaaacag ctatattcat attttagctg
    12361 acagtctggc gtcctttgat tatacccaga ttgagcagat tgttaatgag agtcgtcagg
    12421 tgcaaaggca gaatcgcatg gaaagaattt ccagaccgac gccaatcacc atgcctgtca
    12481 ccaagcagtt atcggctatt atgagggcag aagcccatct actctatcgg atgatggaat
    12541 cccctcttgt tttgaacgat taccgtttgc gagaagactt tgcatttgct acacctgaat
    12601 ttcaggtctt atatgacttg cttggccagt atggaaatct tcctccagaa gttttagcag
    12661 agcagacaga ggaagttgaa agagcttggt accaagtttt agctcaggat ttgcctgctg
    12721 agatatcgcc gcaggaactt agtgaagtag agatgactcg aaacaaggct ctcttgaatc
    12781 aggacaatat gagaatcaaa aagaaggtgc aggaagctag ccatgtagga gatacagata
    12841 cagccctaga agaattggaa cgtttaattt cccaaaagag aagaatggag taataatggc
    12901 aacaaaacaa aaagaagtaa caacatttga cgtacaggta gcagaattta tccgtaatca
    12961 taagcaaaaa gggacagcaa cagatgatga aatcaatgca agtctggtta ttccttttac
    13021 cttggacgct gatgggattg aagatctctt gcaacggatt caggatgcag gcatttctat
    13081 cacagataac gaaggaaatc caagtgcgcg tgttcttagc aatgaagaag aaccagaact
    13141 cagcgatgag gacttgattg ggtcaacttc tgctaaggtc aatgaccctg tccgtatgta
    13201 cttgaaagaa ataggggtcg ttcctctctt gaccaatgaa gaggagaaag agttggcact
    13261 ggctgttgaa gctggtgata tcgaagccaa acaacgtctt gcggaagcca atcttcgttt
    13321 ggttgtttcc attgccaaac gctatgtcgg tcgtggcatg cagttccttg acttgattca
    13381 agaaggaaat atgggcttga tgaaggcggt tgacaagttt gactattcta aagggttcaa
    13441 gttttcaact tatgcaactt ggtggattcg tcaggctatc actcgtgcta ttgcggacca
    13501 agctcgtacc atccgtatcc cagttcacat ggttgaaact atcaataaat tggttcgtga
    13561 acagcggaat ctccttcaag aattggggca agatccgaca ccagaacaga ttgctgaacg
    13621 aatggatatg acacctgata aggttcgtga aatcttgaag attgcccaag aaccagtatc
    13681 tcttgaaact cctatcggtg aagaggacga tagccacctt ggagacttta tcgaagatga
    13741 agtgattgaa aatccagtgg attatacgac tcgtatcgtc ttgcgtgagc aattggatga
    13801 aatcttagat actcttacag accgtgaaga aaatgttctg cgtctacgtt ttggactaga
    13861 tgatggaaaa atgcgcacac ttgaagatgt ggggaaagtc tttaacgtaa ctcgtgagcg
    13921 tatccgtcag attgaagcaa aggctttgag aaaactacgc caaccaagtc gtagcaaacc
    13981 gcttcgtgat tttattgaag actaagagtg aggaaaatat ggcttataca gaagagcaaa
    14041 ttgaaaacat caaaacacgg attttaacag ccttggaaga agtcatcgac cctgagttgg
    14101 gaatcgatat tgtcaatctt ggtttgatct atgagattcg ttttgacggt gacacagggc
    14161 aaacagagat tgacatgact ttgacaacta tgggttgtcc cttagcagac cttttgacag
    14221 accagattta tgatgctatg atagaggttc cagaagtaac ggatactgag gttaaattag
    14281 tctggtatcc agcctggaca gttgaaaaaa tgagtcgcta tgcccgcatt gccctaggca
    14341 ttaagtaaac atataaaagc atgtgagaga ctgttggaaa agcgaggaaa tttcccctct
    14401 tttcctctag tctctccttt cttttgctga ttttattcaa agaaaatgat ataatagtag
    14461 ttatggagaa aaagaaatta cgcatcaata tgttgagttc aagtgagaaa gtagcaggac
    14521 agggagtttc aggtgcttac cgtgaattag ttcgtcttct tcaccgtgct gccaaggacc
    14581 aattgattgt tacagaaaat cttccaatcg aggcagatgt gactcacttt catacgattg
    14641 attttcccta ttatttatca accttccaaa agaaacgctc agggagaaag attggctatg
    14701 tgcatttctt gccagctaca cttgagggaa gtttgaaaat tccatttttc ttaaagggaa
    14761 ttgtgaaacg ctatgtattt tctttttaca accggatgga gcacttggtt gtggtcaatc
    14821 ctatgtttat tgaggatttg gtagcagctg gtattccacg tgaaaaagtg acctatattc
    14881 ctaactttgt caacaaggaa aaatggcatc ctctaccaca agaagaggta gtcagactgc
    14941 gcacagatct tggtcttagt gacaatcagt ttatcgtagt aggtgctggg caagttcaga
    15001 aacgtaaagg gattgatgac tttatccgtc tggctgagga attgcctcag attaccttta
    15061 tctgggctgg tggcttctct tttggtggta tgacagatgg ttatgaacac tataagaaaa
    15121 ttatggaaaa tccccctaaa aatttgattt ttccaggcat tgtatcgcca gagcggatgc
    15181 gcgaattgta tgctctagcg gatcttttct tgttgcctag ttacaatgag ctctttccta
    15241 tgactatttt agaagctgcg agttgtgagg ctcctattat gttgcgtgat ttagatctct
    15301 ataaggtgat tttggaggga aattatcggg cgacagcggg tagagaagag atgaaagagg
    15361 ctattttgga atatcaagca aatcctgctg ccttaaaaga tctcaaagaa aaggctaaga
    15421 atatttccag agagtattct gaagagcatc tgttacaaat ctggttggac ttttatgaga
    15481 aacaagccgc tttagggaga aagtaaaaag tgaggtaatc tatgcgaatt ggtttattta
    15541 cagataccta ttttcctcaa gtttctggtg ttgcgaccag tattcgaacc ttgaaaacag
    15601 aacttgaaaa gcagggacat gctgttttta tctttacgac gacagataag gatgtcaatc
    15661 gctacgaaga ttggcaaatt atccgcattc caagtgttcc tttctttgct tttaaggatc
    15721 gtcgctttgc ctaccgaggt tttagcaagg cacttgaaat tgctaaacag tatcagctag
    15781 atattatcca tactcagaca gaattttctc ttggcctgtt ggggatttgg attgcgcgtg
    15841 aattgaaaat tccagtcatc catacctatc acacccagta tgaagactat gtccattata
    15901 ttgctaaggg gatgttgatc cggccgagta tggtcaagta tctggttaga ggtttcctgc
    15961 atgatgtgga tggggttatt tgtcctagtg agattgtccg tgacttgcta tctgattata
    16021 aggtcaaggt tgaaaaacgg gtcattccta ctgggattga attagccaag tttgagcgtc
    16081 cggaaatcaa gcaggaaaat ttgaaagaac tgcgtagtaa actagggatt caagatggtg
    16141 aaaagacgtt gcttagtctt tcgagaatct cctatgaaaa aaatattcaa gcagttttag
    16201 cagcctttgc tgatgttctg aaagaggaag acaaggttaa actggtagta gctggggatg
    16261 gcccttatct gaatgacctc aaagagcaag cccagaacct agagattcaa gactcagtca
    16321 tctttacagg gatgattgct cctagtgaga cgtctcttta ctataaagcg gcggatttct
    16381 tcatttcggc atcgacaagc gaaacgcaag gtttgaccta cttggaaagc ttagccagtg
    16441 gaacacctgt cattgctcac ggaaatcctt atttgaacaa cctcatcagt gataaaatgt
    16501 ttggaacctt gtactatgga gaacatgatt tggctggtgc tattttggaa gccctgattg
    16561 caacaccaga catgaacgag cataccttat cagagaaatt gtatgagatt tcagctgaga
    16621 actttgggaa acgagtgcat gagttttatc tggatgccat tatttcaaat aacttccaga
    16681 aagatttggc taaagatgat acggtcagtc agcgtatctt taagacagtt ttgtatcttc
    16741 agcaacaggt ggttgctgta cctgtaaaag gatctagacg catgttgaag gcttcaaaaa
    16801 cacagttgat cagtatgaga gactattgga aagaccatga agaatagaaa gaggaacagc
    16861 tatgaaaaaa acaattaatg agaagcggtc gtgataaaaa gattgcgggt gtttgtgctg
    16921 gggtggccca ttatctggat atggatccga ctatcgttca agtcatttgg ggtgttctta
    16981 cttgctgtta cggagctgga attgtagctt acattatttt atggattatc gcaccagtag
    17041 caactgacta ttgaaaacta gctcaattca tgctaagata atagaaaata gaatgtaacg
    17101 aaggagagaa aaatggcatt tggagataat ggaaatcgta aaaaaactat gtttgagaaa
    17161 ataaccttgt ttatcgtgat tatcatgcta gtagcaagtt tattgggaat ttttgcaact
    17221 gcaattggtg ccctcagtaa tctataaaat agattcaaga aaatttagtg actgggattt
    17281 cccagccctt ttttaaagtg agaagaaata atgagtatgt ttttagatac agctaagatt
    17341 aaggtcaagg ctggtaatgg tggcgatggt atggttgcct ttcgtcgtga aaaatatgtc
    17401 cctaatggag gcccttgggg tggtgatggt ggtcgtggag gcaatgtggt cttcgttgta
    17461 gacgaaggac tacgtacctt gatggatttc cgctacaatc gtcatttcaa ggctgattct
    17521 ggtgaaaaag ggatgaccaa agggatgcat ggtcgtggtg ctgaggacct tagagttcga
    17581 gtaccacaag gtacgactgt tcgtgatgcg gagactggca aggttttaac agatttgatt
    17641 gaacatgggc aagaatttat cgttgcccac ggtggtcgtg gtggacgtgg aaatattcgt
    17701 ttcgcgacac caaaaaatcc tgcaccggaa atctctgaaa atggagaacc aggtcaggaa
    17761 cgtgagttac aattggaact aaaaatcttg gcagatgtcg gtttagtagg attcccatct
    17821 gtagggaagt caacactttt aagtgttatt acctcagcta agcctaaaat tggtgcctac
    17881 cactttacca ctattgtacc aaatttaggt atggttcgca cccaatcagg tgaatccttt
    17941 gcagtagccg acttgccagg tttgattgaa ggggctagtc aaggtgttgg tttgggaact
    18001 cagttcctcc gtcacatcga gcgtacacgt gttatccttc acatcattga tatgtcagct
    18061 agcgaaggcc gtgatccata tgaggattac ctagctatca ataaagagct ggagtcttac
    18121 aatcttcgcc tcatggagcg tccacagatt attgtagcta ataagatgga catgcctgag
    18181 agtcaggaaa atcttgaaga atttaagaaa aaattggctg aaaattatga tgaatttgaa
    18241 gagttaccag ctatcttccc aatttctgga ttgaccaagc aaggtctggc aacactttta
    18301 gatgctacag ctgaattgtt agataagaca ccagaatttt tgctctacga cgagtccgat
    18361 atggaagaag aagcttacta tggatttgac gaagaagaaa aagcctttga aattagtcgt
    18421 gatgacgatg cgacatgggt actttctggt gaaaaactca tgaaactctt taatatgacc
    18481 aactttgatc gtgatgaatc tgtcatgaaa tttgcccgtc agcttcgtgg tatgggggtt
    18541 gatgaagccc ttcgtgcgcg tggagctaaa gatggggatt tggtccgcat tggtaaattt
    18601 gagtttgaat ttgtagacta ggagactggt atgggagata aaccgatatc tttccgagat
    18661 gcggatggta attttgtttc cgccgcagac gtttggaatg aaaagaaatt ggaagaacta
    18721 tttaatcgtc taaatccaaa tcgtgccttg agattggcac gaactaaaaa ggaaaatcca
    18781 tctcagtaaa gaagctaaaa aatcccgtgc ctcatcagac acgggatttt gtggtacgac
    18841 gggcatgtat agcgaactga atctggaata gcacagcata tcttctaaaa tattgttata
    18901 aattgatttg aatttcaaaa ttaaattgtt tgattcttat ttcaatttgt tatagtatat
    18961 ctgatgtcaa agttctcggc gagtcaaata gcgattccca agcctgacta tcgtgaggta
    19021 gcggattaaa atggtctggg gatagaccgt tttaagtctg acgctggaaa taagaattgt
    19081 cagaagaagg gatagcgaaa tcgtggctct acgaacagga acgtgataat aaggcgtata
    19141 tagcggataa gagggcctca aactctaaag tccaaaaagg tagtcgtaac ctatatgcgt
    19201 aaatcacgag agtaattgaa ttcgtactaa gattttctat tttcactgta accttttaac
    19261 gtcctcatat cttgtataca cgaggaaaga tgtacgactt atcccgtgag gtctatcact
    19321 ataaagagaa aacgacagat agaagtgatc ctgagtcacg gttatcttta aaatagattg
    19381 tctgatagga tgctagcctg aaaacgtctt gttcatgaaa tataggacgg tatgtataaa
    19441 acgcttctgt gaactgagag aagggggaga ggttcttgct aaaatttagt tgaacagccg
    19501 tattccgata tttagataag agatctagtc ttagctccta ctcggtttca ggggataaaa
    19561 aaggggcaat agcgattcga gaaagattat actcttcgaa aatctcttca aatcacgtca
    19621 atatcgcctt gccgtacgtg taggatactg actacgtcag ttccatctac aacctcaaaa
    19681 cagtgttttg agcaacctgc ggctagtttc ctagtttgat ctttgatttt tattgagtat
    19741 tagtaattca gttactaact cgtcaactct gatttatcca ataaaattga aaaggatgga
    19801 aaaaaggata aatttatgat atactttatt ttgaagacct tattagaaat cttgaaagag
    19861 tattgaaaac ttagaatgag aaaaattgtt atcaatggtg gattaccact gcaaggtgaa
    19921 attactatta gtggtgctaa aaatagtgtt gtggccttaa ttccagctat tatattggct
    19981 gatgatgtgg tgactttgga ttgtgttcca gatatttcgg atgtagccag tcttgtcgaa
    20041 atcatggaat tgatgggagc tactgttaag cgttatgacg atgtcttgga gattgatcca
    20101 agaggtgttc aaaatattcc aatgccttat ggtaaaatta acagtcttcg tgcatcttat
    20161 tatttttatg ggagcctctt aggccgtttt ggtgaagcga cagttggtct accgggagga
    20221 tgtgatcttg gtcctcgtcc gattgactta caccttaagg cgtttgaagc tatgggtgcc
    20281 actgctagct acgagggaga taacatgaag ttatctgcta aagatacagg acttcatggt
    20341 gcaagtattt acatggatac ggttagtgtg ggagcaacga ttaatacgat gattgctgcg
    20401 gttaaagcaa atggtcgtac tattattgaa aatgcagccc gtgaacctga gattattgat
    20461 gtagctactc tcttgaataa tatgggtgcc catatccgtg gggcaggaac taatatcatc
    20521 attattgatg gtgttgaaag attacatggg acacgtcatc aggtgattcc agaccgcatt
    20581 gaagctggaa catatatatc tttagctgct gcagttggta aaggaattcg tataaataat
    20641 gttctttacg aacacctgga agggtttatt gctaagttgg aagaaatggg agtgagaatg
    20701 actgtatctg aagacagcat ttttgtcgag gaacagtcta atttgaaagc aatcaatatt
    20761 aagacagctc cttacccagg ctttgcaact gatttgcaac aaccgcttac ccctctttta
    20821 ctaagagcga atggtcgtgg tacaattgtc gatacgattt acgaaaaacg tgtaaatcat
    20881 gtttttgaac tagcaaagat ggatgcggat atttcgacaa caaatggtca tattttgtac
    20941 acgggtggac gtgatttacg tggggccagt gttaaagcga ccgacttaag agctggggct
    21001 gcactagtca ttgctgggct tatggctgaa ggtaaaactg aaattaccaa tatcgagttt
    21061 atcttacgtg gttattctga tattatcgaa aaattacgta atttaggagc ggatattaga
    21121 cttgttgagg attaaaccgt agaggtgttt atgaatattt ggaccaaatt agcaatgttt
    21181 tctttttttg aaacggatcg cttgtatttg cgtcctttct tttttagtga tagtcaggac
    21241 ttccgcgaga tagcttcaaa tccagaaaat cttcaattta ttttcccaac gcaggcaagt
    21301 ctggaagaaa gtcaatatgc actggccaat tactttatga agtccccttt gggagtgtgg
    21361 gcaatttgtg accagaaaaa tcaacaaatg attggttcta ttaaatttga gaagttagat
    21421 gaaatcaaaa aagaagctga gcttggctat tttttgagaa aagatgcttg ggcgcaagga
    21481 tttatgacag aggttgttag aaaaatttgt cagctttctt ttgaggaatt tggcttaaaa
    21541 caattatcta tcattaccca ccttgaaaat gaagctagcc aaagagttgc tcttaagtct
    21601 ggatttagtt tgttccgtca gtttaaggga agtgatcgtt acacaagaaa aatgcgggat
    21661 tatcttgaat ttcggtatgt aaaaggagag ttcaatgagt aagcatcagg aaattctaag
    21721 ctatttggag gaattaccag taggtaaaag ggtcagtgtt cgtagcattt cgaatcatct
    21781 aggagttagt gatggaacag cctatcgggc tattaaagaa gctgaaaacc gtggaattgt
    21841 ggagacccgt cctagaagtg gaacaattcg tgttaaatcc cagaaagttg ctatagagag
    21901 attaacgttt gctgaaattg cagaagtgac ttcttctgag gttctggctg ggcaagaagg
    21961 tttagagaga gaatttagca agttttcaat tggtgccatg actgaacaaa atatcttgtc
    22021 ttaccttcat gatggggggc tcttgattgt cggagaccga acccgtattc agttgctagc
    22081 cttggaaaat gaaaatgcag ttctggttac agggggattt caggttcatg atgatgtgct
    22141 taaactggcc aatcaaaaag ggattcctgt tctaagaagt aagcatgata cctttaccgt
    22201 cgcgaccacg atcaataaag ccttgtcaaa tgtccaaatc aagactgata ttctgacagt
    22261 tgagaaactt tatcgcccta gtcatgagta tggttttctg agagagacag atacagttaa
    22321 agattatttg gacttggttc gtaagaatcg tagcagccgt ttccctgtta tcaatcaaca
    22381 tcaggtcgtt gttggcgttg taaccatgag agacgctggt gataaatcac caagcacgac
    22441 aattgataag gttatgtctc gtagtctatt tttggttgga ttatcgacaa atattgccaa
    22501 tgtgagtcaa cggatgatcg cagaagactt tgaaatggta ccagttgttc gaagcaatca
    22561 aactttgctt ggcgttgtga cgcgacgaga tgtcatggag aagatgagcc gttcccaagt
    22621 ttcggctcta ccaacttttt ctgagcagat tggacaaaag ctctcttatc accatgatga
    22681 agtagtcatt acagtggaac cctttatgct agaaaaaaat ggagttttgg ctaatggtgt
    22741 attggcagaa attctgaccc acatgaccca agatttagtt gttaatagtg gtcgcaatct
    22801 cattatcgag cagatgctga tctacttttt gcaggctgtt cagatagatg atatattgcg
    22861 cattcaggca cggattattc atcatacgag acggtcagct ataattgatt acgatattta
    22921 tcatggtcac cagattgttt caaaagcaaa tgtgactgtt aaaattaatt agaaactagg
    22981 agaaaagatg ataacattaa aatcagctcg tgaaatcgaa gctatggaca aggctggtga
    23041 ttttctagca agtattcata taggcttacg tgatttgatt aaaccaggcg tagatatgtg
    23101 ggaagttgaa gaatatgtcc gccgtcgttg taaagaagaa aatttccttc cacttcagat
    23161 tggggttgac ggtgccatga tggactatcc ttatgctacc tgttgctctc ttaacgatga
    23221 agtggctcac gctttccctc gtcattatat cttgaaagat ggtgatttgc tcaaagttga
    23281 tatggttttg ggaggtccca ttgctaaatc cgacctgaat gtctcaaaat taaacttcaa
    23341 caatgttgaa caaatgaaaa aatacactca gagctattct ggtggtttag cagactcatg
    23401 ttgggcttat gctgttggta caccgtccga agaagtcaaa aacttgatgg atgtaaccaa
    23461 agaagctatg tacaagggta ttgagcaagc tgttgttgga aatcgtatcg gtgatatcgg
    23521 tgcggctatt caagaatacg ctgaaagtcg tggttacggt gtagtgcgtg atttggttgg
    23581 tcatggtgtt ggcccaacta tgcacgaaga accaatggtt cctaactatg gtattgcagg
    23641 tcgtggactc cgtcttcgtg aaggaatggt cttaaccatt gaaccaatga tcaatacagg
    23701 cgattgggaa attgatacag atatgaaaac tggttgggcg cataagacca ttgacggtgg
    23761 attgtcatgt cagtatgaac accaatttgt cattacgaaa gatggacctg ttatcttgac
    23821 tagccaaggt gaagaaggaa cttattaata aaaagtgaaa agactactgg aagtttattt
    23881 tgataaaaaa tccagtagat cttttcataa taaaatgcat tgtatcaagt gttaggggct
    23941 gatatcatgc gtttttctgc ttttaagatt ttttccaact ctgtttgtaa gcgcatcata
    24001 acaaagggtc taggattcag ggctctcctc ctatatacta ttagtaaagt aaaactaagg
    24061 gaggatattt tagtgtcgca gtctattgtt cctgtagaga ttccacaata ttgtcgtttt
    24121 gattctaaaa agagaaatgg aattctattt aacgttcgta ttgccaatct taaatttact
    24181 tttttatatt atacttcctg cgaaacaaaa tatggtatag tagttctatg aat
//
LOCUS       DAVHSO010000030        24010 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.030, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000030 DAVHSO010000000
VERSION     DAVHSO010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 24010)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24010)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24010
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.030"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            337..2490
                     /locus_tag="VVR18_001217"
     CDS             337..2490
                     /locus_tag="VVR18_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="HEU6032744.1"
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKT
                     TMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTG
                     QDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
                     LVKQRGLIANIVLATLLVTGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIL
                     QQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSII
                     DALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNR
                     DTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQK
                     ALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQT
                     AQVANNRLNEVYLVASEFEEKKTVEDLSLMKGEMTFKQVHYKYGYGRDVLSDINLTVP
                     QGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLDGVNLNQIDKKALRQYINYLPQQ
                     PYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISG
                     GQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAE
                     RTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS"
     gene            2503..3852
                     /locus_tag="VVR18_001218"
     CDS             2503..3852
                     /locus_tag="VVR18_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyD family secretion protein"
                     /protein_id="HEU6032745.1"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKE
                     MSLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESY
                     ASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
                     ETIASQNAAASQTQSEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYK
                     SQGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQ
                     HLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEG
                     ALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSID
                     ATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            4023..4730
                     /locus_tag="VVR18_001219"
     CDS             4023..4730
                     /locus_tag="VVR18_001219"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HEU6032746.1"
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAG
                     KGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSK
                     RFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINEL
                     LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLG
                     ELTDVYEIVWEKLQELK"
     gene            4932..8657
                     /locus_tag="VVR18_001220"
     CDS             4932..8657
                     /locus_tag="VVR18_001220"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HEU6032747.1"
                     /translation="MDKRIFVEKKADFQVKSESLVRELQHNLGLSSLKSIRIVQVYDV
                     FDLAEDLFAPAEKHIFSEQVTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQE
                     ALLLLGSSSDVTVNTAQLYLVNKDIDATELKAVKNYLLNLVDSRFKDITTGIAKQEFS
                     ESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVL
                     DTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMA
                     TIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
                     GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGY
                     SSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGK
                     TGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDF
                     GAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDTFVA
                     ECNKENIDAVVVATVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVDAKVVDKDVKL
                     PEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEA
                     SVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEATARLVAAGANWSKARF
                     SYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLV
                     AFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEASQADHKVT
                     SASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGGFVFTSPEEIAGVEKIG
                     QTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKE
                     KVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDK
                     TNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVK
                     SGLLPYGNFEDANSTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVS
                     HGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQI
                     IGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK"
     gene            8750..10192
                     /locus_tag="VVR18_001221"
     CDS             8750..10192
                     /locus_tag="VVR18_001221"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HEU6032748.1"
                     /translation="MTYEVKSLNEECGVFGIWGHPDAAKLTYFGLHSLQHRGQEGAGI
                     LSNDQGQLKRHRDMGLLSEVFRNPANLDKLTGAGAIGHVRYATAGEASVDNIQPFLFR
                     FHDMQFGLAHNGNLTNAASLKKELEQRGAIFSATSDSEILAHLIRRSHNPSLMGKIKE
                     ALSLVKGGFAYILLFEDKLIAALDPNGFRPLSIGKMANGAVVVSSETCAFEVIGAEWI
                     RDLKPGEIVIIDDEGIQYDSYTDDTQLAICSMEYIYFARPDSNIHGVNVHTARKRMGA
                     QLAREFKHEADIVVGVPNSSLSAAMGFAEESGLPNEMGLIKNQYTQRTFIQPTQELRE
                     QGVRMKLSAVSGVVKGKRVVMVDDSIVRGTTSRRIVQLLKEAGATEVHVAIGSPALAY
                     PCFYGIDIQTRQELIAANHTVEETRQIIGADSLTYLSIDSLIESIGIETDAPNGGLCV
                     AYFDGDYPTPLYDYEEDYRRSLEEKTSFYK"
     gene            10229..11251
                     /locus_tag="VVR18_001222"
     CDS             10229..11251
                     /locus_tag="VVR18_001222"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HEU6032749.1"
                     /translation="MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFG
                     GMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGADPL
                     YFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
                     GVAEKSQIIDGSKVVEGDVLLGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLK
                     EVLLEPTRIYVKAVLPLIKEELVNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVL
                     PIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLDEAVYEIGRIVKKEN
                     ESVIIK"
     gene            11248..11793
                     /gene="purN"
                     /locus_tag="VVR18_001223"
     CDS             11248..11793
                     /gene="purN"
                     /locus_tag="VVR18_001223"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HEU6032750.1"
                     /translation="MKKIAVFASGNGSNFQVIAEEFPVEFVFSDHRDAYVLERAKQLG
                     VLSYAFELKEFESKTDYEAALVELLEEHQIDLVCLAGYMKIVGPTLLSAYEGRIVNIH
                     PAYLPEFPGAHGIEDAWNAGVGQSGVTIHWVDSGVDTGQVIKQVRVPRLADDTIDRFE
                     ARIHEAEYRLYPEVVKALFTD"
     gene            11877..12386
                     /locus_tag="VVR18_001224"
     CDS             11877..12386
                     /locus_tag="VVR18_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000894002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HEU6032751.1"
                     /translation="MLESKKTTRYVFYVYLMLLTWGILFKFETNPEFIAFFLAPRYIN
                     WIPFSEPLIVDGKIVFAEMLFNLISFIPLGVCFPLIKTNLSSLRIVGTGFLISLLFEC
                     LQYILAIGITDITDLTLNTLGVCVGLLIYQIFIRVFKSQTRKWINILGMLSLGFAYLV
                     LLLLHLIGV"
     gene            12411..13958
                     /gene="purH"
                     /locus_tag="VVR18_001225"
     CDS             12411..13958
                     /gene="purH"
                     /locus_tag="VVR18_001225"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HEU6032752.1"
                     /translation="MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGV
                     DTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNL
                     YPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAAN
                     GETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENP
                     QQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHM
                     NPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSY
                     TDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQV
                     VTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQA
                     KDRLNGAVLASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFT
                     GVRHFRH"
     gene            14080..15342
                     /gene="purD"
                     /locus_tag="VVR18_001226"
     CDS             14080..15342
                     /gene="purD"
                     /locus_tag="VVR18_001226"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HEU6032753.1"
                     /translation="MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLEL
                     VNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKAFGPTRAAAELEW
                     SKDFAKEIMVKYGVSTAAYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVAETV
                     EQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFVNGDKFYIMPTAQDHKRAY
                     DGDKGPNTGGMGAYAPVPHLPQSVVDTAVDTIVKPVLEGMIKEGRPYLGVIYAGLILT
                     ADGPKVIEFNSRFGDPETQIILPRLTSDFAQNITDILDSKEPNIMWTDKGVTLGVVVA
                     SKGYPLDYERGVELPAKTEGDVITYYAGAKFAENSRALLSNGGRVYMLVTTVATVKEA
                     QASIYQELSQQKIEGLFYRTDIGSKAIK"
     gene            15745..16233
                     /gene="purE"
                     /locus_tag="VVR18_001227"
     CDS             15745..16233
                     /gene="purE"
                     /locus_tag="VVR18_001227"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000805607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HEU6032754.1"
                     /translation="MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPD
                     LMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYSI
                     VQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
                     LI"
     gene            16220..17311
                     /gene="purK"
                     /locus_tag="VVR18_001228"
     CDS             16220..17311
                     /gene="purK"
                     /locus_tag="VVR18_001228"
                     /EC_number="6.3.4.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide
                     synthase"
                     /protein_id="HEU6032755.1"
                     /translation="MSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPASRV
                     AEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNR
                     IFEKDFLSNKAQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEAD
                     LEAAYALADSADCVLEEFVNFDLEISVIVSGNGNEVTFFPVQENIHRNNILSKTIVPA
                     RISESLADKAKAMAVRIAEQLNLSGTLCVEMFATDDDVIVNEIAPRPHNSGHYSIEAC
                     DFSQFDTHILGVLGAPLPVIKLHAPAVMLNVLGQHVEAAEQYVTENSSAHLHMYGKIE
                     AKHNRKMGHVTLFSDVPDSVDELGEGIDF"
     gene            17321..17548
                     /locus_tag="VVR18_001229"
     CDS             17321..17548
                     /locus_tag="VVR18_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HEU6032756.1"
                     /translation="MIQIIVNTFIEKDKTGAVVEVLYASADQDKVQAKYEELAAQYPE
                     NYLAIYDVPLDTDLNTLDHYPSVFIGKEEFE"
     gene            17611..18909
                     /gene="purB"
                     /locus_tag="VVR18_001230"
     CDS             17611..18909
                     /gene="purB"
                     /locus_tag="VVR18_001230"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HEU6032757.1"
                     /translation="MINRYSRPEMANIWSEENKYRAWLEVEILSDEAWAELGEIPKED
                     VALIRKKADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAY
                     GYLYKQANDIIRRDLENFTNIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSE
                     MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRAQEISTQVLPRDL
                     HAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSEN
                     MTGLARVIRGHMITAYENVALWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNL
                     TVFPENMIRNMNSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAYSWDNQVDFKPL
                     LEADSEVTSRLTQEEIDEIFNPVYYTKRVDDIFERLGLGD"
     gene            complement(18964..22926)
                     /gene="strH"
                     /locus_tag="VVR18_001231"
     CDS             complement(18964..22926)
                     /gene="strH"
                     /locus_tag="VVR18_001231"
                     /EC_number="3.2.1.52"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HEU6032758.1"
                     /translation="MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTEN
                     QPTIHTVSDSPQSSENRTEETPKAELQPEAPKTVETEAPKTVETETPATDKVASLPKT
                     EEKPQEEVSSTPSDKAEVVTPTSAEKETANKKEEEASPKKEEAKEVDSKESNTDKTDK
                     DKPAKKDEAKAEADKPETETGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDK
                     AKHYGYTDLHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNH
                     LTESQMTDLINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKKSARTV
                     DLDNEQAVAFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNE
                     GYPVKGYEKFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGG
                     WGGYDVASSKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVP
                     KTEGADIPIIGGMVAAWADTPSARYSPSRLFKLMRHFANANAEYFAADYESAEQALNE
                     VPKDLNRYTAESVAAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEA
                     QKEEEAKREVEKLAKNKVISIDAGRKYFTLNQLKRIVDKASELGYSDVHLLLGNDGLR
                     FLLDDMTITANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIG
                     LIPAINSPGHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMD
                     FFAGKTKIFNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMA
                     FNDGFYYEDKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYILG
                     QKPEDGGGFLKKAIENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEI
                     FELMTAFADHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRN
                     KQAELDTLVANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKK
                     ENPNLPAGQENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGSPV
                     THKGDESGLAPTTEVKPRLDIQEEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFY
                     SVSTSADGKEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQ
                     PAPSTAPAEESKALPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED
                     "
     gene            complement(23241..23957)
                     /locus_tag="VVR18_001232"
     CDS             complement(23241..23957)
                     /locus_tag="VVR18_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU6032759.1"
                     /translation="MAIPKYQYIKDELKNKIISGQFSSGDKFYTEAELISMYDVSSIT
                     VVRALNDLAKDGYIVRQQGKGTFVSRARKHKLVEFSDIELFNAKDDKVTVLSIERGNK
                     LVYLEKLGLRGDQFYYKIERIRESNGVVYIYHTSYIPEQYINANYPNLEYYSSIYNRF
                     KLDYHIHMNDEHFEEINEIVFPTPEHAASVLGVDEQFPTVLQTKITKLESTGQVLEYS
                     ETYKRSDYYKIKFISCDRDH"
BASE COUNT         6502 a         4781 c         5724 g         7003 t
ORIGIN      
        1 atttcggttt tgttaacttg taattcttat attttctagg tagaacgttt gttctgccta
       61 tttttttatc caaaaagtgc agttgggagg gagataggct catttgggaa ggaagtccag
      121 tttttgttta gtgattgggg taagatagtt gttatcagat gagtttatac tcttcgaaaa
      181 tcaaattcaa accacgtcaa cgtcgccttg ccgtatatat gtgactgact tcgtcagtcc
      241 tatctacaac ctcaaaacag tgttttgagc agcctgcggc tagtttccta gtttgctctt
      301 tgattttcat tgagtattag ggaaaaggag atgaatatga aatttgggaa acgtcactat
      361 cgtccgcaag tggatcagat ggactgcggt gtagcttcat tagccatggt ttttggctac
      421 tatggtagtt attatttttt ggctcacttg cgagaattgg ctaagacgac catggatggg
      481 acgacggctt tgggcttggt caaggtggca gaggagattg gttttgagac gcgagccatt
      541 aaggcggata tgacgctttt tgacttgccg gatttgactt ttccttttgt tgcccatgtg
      601 cttaaggaag ggaaattgct ccactactat gtggtgactg ggcaggataa ggatagcatt
      661 catattgccg atccagatcc cggggtgaag ttgactaaac tgccacgtga gcgttttgag
      721 gaagaatgga caggagtgac tctttttatg gcacctagtc cagactataa gccttataag
      781 gaacaaaaaa atggtctgct ctcttttatc cctatattag tgaagcagcg tggcttgatt
      841 gccaatatcg ttttggcaac actcttggta accgggatta acattgtggg ttcttattat
      901 ctgcagtcta tcattgatac ctatgtgcca gatcagatgc gttcgacact agggattatt
      961 tctattgggc tagtcatcgt ctacatcctc cagcaaatct tgtcttacgc tcaggagtat
     1021 ctcttgcttg ttttggggca acgcttgtcg attgacgtga ttttgtccta tatcaagcat
     1081 gtttttcacc tccctatgtc cttctttgcg acacgcagga caggggagat cgtgtctcgt
     1141 tttacagatg ctaacagtat catcgatgcg ctggcttcga ccatcctttc gattttccta
     1201 gatgtgtcaa cggttgtcat tatttccctt gttctatttt cacaaaatac caatctcttt
     1261 ttcatgactt tattggcgct tcctatctac acagtgatta tctttgcctt tatgaagccg
     1321 tttgaaaaga tgaatcggga taccatggaa gccaatgcgg ttctgtcttc ttctatcatt
     1381 gaggacatca acggtattga gactatcaag tccttgacca gtgaaagtca gcgttaccaa
     1441 aaaattgaca aggaatttgt ggattatctg aagaaatcct ttacctatag tcgagcagag
     1501 agtcagcaaa aggctctgaa aaaggttgcc catctcttgc ttaatgtcgg cattctctgg
     1561 atgggggctg ttctggtcat ggatggcaag atgagtttgg ggcagttgat tacctataat
     1621 accttgctgg tttactttac caatcctttg gaaaatatca tcaatctgca aaccaagctt
     1681 cagacagcgc aggttgccaa taaccgtcta aatgaagtgt atctagtagc ttctgagttt
     1741 gaggagaaga aaacagttga ggatttgagc ttgatgaagg gagagatgac cttcaagcag
     1801 gttcattaca agtatggcta tggtcgagac gtcttgtcgg atatcaattt aaccgttccc
     1861 caagggtcta aggtggcttt tgtggggatt tcagggtcag gtaagacgac tttggccaag
     1921 atgatggtta atttttacga cccaagtcaa ggggagatta gtctggatgg tgtcaatctc
     1981 aatcagattg ataaaaaagc cctgcgccag tacatcaact atctgcctca acagccctat
     2041 gtctttaacg gaacgatttt ggagaatctt cttttgggag ccaaggaggg gacgacacag
     2101 gaagatatct tacgggcggt cgaattggca gagattcgag aggatatcga gcgcatgcca
     2161 ctgaattatc agacagaatt gacttcggat ggggcaggga tttcaggtgg tcaacgtcag
     2221 agaatcgctt tggcgcgtgc tctcttgaca gatgcgccgg tcttgatttt ggatgaggcg
     2281 actagcagtt tggatatttt gacagagaag cggattgtcg ataatctcat ggctttggac
     2341 aagaccttga ttttcattgc tcaccgcttg actattgctg agcggacaga gaaggtggtt
     2401 gtcttggatc agggcaagat tgtcgaagaa ggaaagcatg ctgatttgct tgcacagggt
     2461 ggcttttacg cccatttggt caatagctag aaagaggaga ggatgaaacc agaattttta
     2521 gaaagtgcgg agttttataa tcgtcgttac cataattttt ccagtagtgt gattgtaccc
     2581 atggcccttc tgctcgtgtt tttacttggc tttgcaactg ttgcagaaaa ggagatgagt
     2641 ttgtccacta gagctactgt cgaacctagt cgtatccttg caaatatcca gtcaactagc
     2701 aacaatcgta ttcttgtcaa tcatttggaa gaaaataagc tggttaagaa gggagatctt
     2761 ttggttcaat accaagaagg ggcagagggt gtccaagcgg agtcctatgc cagtcagttg
     2821 gacatgctaa aggatcaaaa aaagcaattg gagtatctgc aaaagagcct gcaagaaggg
     2881 gagaaccact ttccagagga ggataagttt ggctaccaag ccacctttcg cgactacatc
     2941 agtcaagcag gcagtcttag ggctagtaca tcgcaacaaa atgagaccat cgcgtcccag
     3001 aatgcagcag ctagccaaac ccaatccgaa atcggcaacc tcatcagtca aacagaggct
     3061 aaaattcgcg attaccagac agctaagtca gctattgaaa caggtgcttc cttggccggt
     3121 cagaatctag cctactctct ttaccagtcc tacaagtctc agggcgagga aaatccccaa
     3181 actaaggttc aggcagttgc acaggttgaa gcacagattt ctcagttaga atctagtctt
     3241 gctacttacc gtgtccagta tgcaggttca ggtacccagc aagcctatgc gtcagggtta
     3301 agcagtcaat tggaatccct taaatcccaa cacttggcaa aggttggtca ggaattgacc
     3361 cttctagccc agaaaatctt ggaggcagag tcaggtaaga aggtacaggg aaatctttta
     3421 gacaagggga aaattacggc gagtgaggat ggggtgcttc atcttaatcc tgagaccagt
     3481 gattctagca tggttgcaga aggtgcccta ctagctcaac tttatccatc tttggaaaga
     3541 gaagggaaag ccaaactcac agcttatcta agttcaaaag atgtagcaag aatcaaggtc
     3601 ggtgattctg ttcgctatac tacgactcat gatgccggga atcaactttt cctagattct
     3661 actattacaa gtattgatgc gacagctact aagactgaga aagggaattt ctttaaaatc
     3721 gaggcggaga ctaatctaac ttcggagcag gctgaaaaac ttaggtacgg ggtggaaggc
     3781 cgcttgcaga tgattacggg caagaaaagt tacctacgtt attatttgga tcaatttttg
     3841 aacaaagagt aatgttcgtg tttttagagt taaataattt ttaaactgtg agaaagattc
     3901 ttcttgcagt ttttttcttt acaatttttg aaaaatatct gctatttatt cggttaaatt
     3961 cttgtgtttt ttggtttttt gtggtaaaat gtgctcaagt aatacgaaag gcgaacttta
     4021 aaatgtcaaa acaattgatc tattcgggaa aagctaaaga tatctataca actgaggatg
     4081 aaaatcttat tatttcaact tacaaggacc aggcgactgc tttcaacggt gtcaagaagg
     4141 agcagattgc aggtaaggga gtcttgaata atcagatctc atcttttatt tttgagaaat
     4201 taaatgcggc tggtgtggcg actcactttg tggagaaact ttcagacacg gaacaactca
     4261 ataaaaaggt taagattatt cctttggaag tcgtgctccg caactatact gctggttcct
     4321 tttcaaaacg ttttggtgtg gatgagggaa tcgccttgga gactccgatt gtcgaatttt
     4381 actacaaaaa tgatgatttg gatgatccat ttatcaatga tgagcatgtg aaattcctac
     4441 agattgcggg tgaccagcag attgcctact tgaaggaaga aacgcgtcgt atcaatgaac
     4501 tattgaaagt ctggtttgct gagattgggc ttaaattgat tgactttaag ctagagttcg
     4561 gttttgacaa ggatggcaag attatcttgg cagacgaatt ttcaccagat aactgccgct
     4621 tgtgggacgc tgatggcaac cacatggata aggatgtttt ccgtagagga ttgggagaac
     4681 taaccgacgt ttatgagatt gtttgggaaa agttgcagga attgaaataa tctgtttgca
     4741 acggaaaacc ttcgtctctc aactaaaagg actcaggctg aaaaggtccc ccagaccttt
     4801 tcactctgta gagaactagg tgaactaaca gatgtttacg aaattgtctg ggaaaagttg
     4861 cagggtttaa aataacaacc tcaaggctgt ttgggaatat tgcaagagct gaaataaagg
     4921 aataagaatt gatggataaa cgtatttttg ttgaaaaaaa ggctgatttt caggtcaagt
     4981 cagagagttt ggttagagag ctccagcaca acttgggact gtcaagcttg aaaagtattc
     5041 gtattgtgca agtatatgat gtatttgact tggctgagga cttgtttgca cctgcagaga
     5101 agcacatttt ctctgagcag gtaaccgacc atgttttaga tgaagtatct gtgcaggcgg
     5161 atcttgctaa ctatgctttc tttgccattg aaagtctgcc agggcagttt gaccagcgtg
     5221 cagcttcgtc acaggaagcc ttgcttttgt tgggaagttc gagtgacgtg acagtcaaca
     5281 cagcccaact ttacttggtg aataaagata ttgatgcgac tgagttgaaa gctgtcaaaa
     5341 actacctgct caatctagtt gattctcgtt tcaaggatat cacgacaggg attgccaagc
     5401 aggagttttc agagtcagac aagaccattc caaaattgac tttctttgaa agctatacag
     5461 cagaagattt tgctcgctac aaggccgaac aagggatggc catggaagtg gatgatttgc
     5521 tctttatcca agactacttt aagtcaatcg ggcgcgtgcc aactgagact gaacttaagg
     5581 ttttggacac ttactggtct gaccactgcc gtcatacgac ttttgagaca gagttgaaac
     5641 acatcgactt ttcagcttct aaatttcaaa agcaattgca gtcaacctat gacaagtata
     5701 ttgccatgcg cgaggaatta ggtcggtctg aaaaaccaca aaccttgatg gatatggcga
     5761 ctattttcgg tcgttatgag cgtgctaatg gacgattgga tgatatggaa gtctctgacg
     5821 aaatcaatgc ctgctcagtt gaaattgaag tggacgttga tggtgtcaag gaaccttggc
     5881 tcctcatgtt taaaaacgaa acccacaacc atccaacaga aattgagcca tttggtggag
     5941 cggctacctg tattggtgga gctattcgtg atccgttgtc aggccgttcc tatgtttacc
     6001 aagccatgcg tatttcaggt gctggtgata ttacagcacc gatttcggaa actcgcgctg
     6061 ggaaattgcc acaacaagtc atttctaaaa cagcagctca tggttattct tcatatggta
     6121 accagattgg gcttgccaca acctacgttc gtgaatactt ccacccaggc tttgtagcta
     6181 aacgtatgga acttggtgcc gttgttggtg cggctcccaa gggcaatgtt gtccgtgaaa
     6241 aacctgaagc aggtgatgtg atcatccttc tcggaggtaa aacaggtcgt gatggtgtcg
     6301 gtggtgcgac gggctcttct aaggttcaaa cagttgagtc tgtagagact gctggtgctg
     6361 aggttcaaaa aggaaatgcc atcgaagaac gcaagattca gcgcctcttc cgtaatggca
     6421 atgtcactcg tctgatcaag aagtccaatg actttggggc aggcggtgtc tgtgtggcta
     6481 tcggtgaatt ggcagacggt cttgaaatcg acctcaacaa ggtgcctctt aaataccagg
     6541 gcttgaatgg tacagaaatt gccatctctg aatcacaaga acggatggcg gtcgtggttc
     6601 gtcctgaaga tgtggatacc ttcgttgccg aatgtaacaa agaaaatatt gatgctgttg
     6661 tggtggcgac agtaactgaa aaaccaaatc ttgtcatgca ctggaatggt gagacaatcg
     6721 ttgacttgga gcgtcgtttc cttgacacca atggtgtgcg cgtggttgtc gatgccaaag
     6781 ttgtggacaa ggatgtcaaa ctcccagaag agcgtcaaac atctgctgaa acactggaat
     6841 cagataccct tacggttcta tctgacctca accatgcaag tcaaaaagga ttacagacta
     6901 tctttgactg ctctgttgga cgctcaacgg ttaatcaccc acttggtggt cgttaccaac
     6961 tcacaccaac tgaggcatct gtgcagaaat tgccagttca acacggtgtg actcatactg
     7021 cgtcggtcat tgctcaaggt ttcaacccat atgtagctga atggtctcca taccacggtg
     7081 ctgcttatgc ggttatcgaa gcaactgctc gtttggtggc tgctggtgcc aactggtcta
     7141 aggctcgttt ctcttaccaa gaatatttcg agcggatgga caagcaagca gagcgtttcg
     7201 gtcagccagt agctgctctt ctaggttcta ttgaagcaca aattcagctt ggcttgccat
     7261 ctatcggtgg taaggactcc atgtctggta cctttgaaga attgaccgtt ccgccaacct
     7321 tggttgcctt tggggtgacg acggcagata gccgtaaggt gctctctcca gaatttaaag
     7381 ctgttgggga aaatatctac tacatcccag gtcaagccct ctctgcagag attgattttg
     7441 acttgattaa gaaaaatttt gctcagtttg aagcaagcca agctgaccat aaagtgacgt
     7501 ctgcatcagc tgtcaaatac ggtggtgtag ttgaaagttt ggctcttgct acctttggaa
     7561 actatattgg tgcagaggtg accttgcctg aacttaaaac agctttgaca gctcaattag
     7621 gcggctttgt cttcacatct cctgaagaaa ttgctggagt agagaagatt ggacaaacga
     7681 aagcagactt tacactgact gtcaacggtg tgaagctaga tggacacaag cttgacagtg
     7741 catttcaagg gacattggaa gaagtttacc caacagaatt tacccaagcg aaagaactag
     7801 aagaagtacc agctgtggca tcagatgttg tgattaaagc caaagaaaag gttgaaaaac
     7861 ctgtggttta catcccagtc tttccaggaa ccaactcaga atatgattca gctaaggcct
     7921 tcgaaaaaga aggtgcagag gtcaatttgg tgccattcgt gaccttgaat gaagaagcta
     7981 ttgtcaagtc agttgaaact atggttgaca atatcgacaa gactaatatt ctcttctttg
     8041 ccggtggatt ctcggctgcg gatgaaccag atggttcagc taagtttatc gtcaatatcc
     8101 tgcttaatga aaaagtgcgt gtggctattg atagctttat cgcccgtggt ggcttgatta
     8161 tcggtatttg taatggattc caagccttag tcaaatcggg tctcctacca tacggaaact
     8221 ttgaagatgc taacagtact agtccaaccc tcttctacaa tgatgccaac caacacgtgg
     8281 ccaagatggt ggaaactcgc attgccaata ccaactcacc atggttggct ggtgtgcaag
     8341 tgggcgatat ccacgctatt cctgtttcgc acggtgaagg gaagtttgtc gtgacggctg
     8401 aggaatttgc agagctccgt gacaatggac aaattttcag ccaatacgtt gactttaacg
     8461 gtaaaccaag tatggattct aagtacaatc cgaatggttc tgtccatgcc atcgaaggaa
     8521 ttaccagcaa gaatggtcaa atcatcggta agatgggcca ctcagaacgt tatgaggatg
     8581 gtcttttcca aaatatccca ggcaataaag accaacacct gttcgcatca gcggttaaac
     8641 atttcactgg aaaataagac ttacagattt tctaatagat agtatcagta atgtaaaagt
     8701 catgtaaatc tagctcttga tgattacaaa tgaaaattag gtataaaaaa tgacatacga
     8761 agtaaaatct cttaatgaag aatgtggtgt tttcggtatt tggggacatc cagatgctgc
     8821 taagttgacc tattttggac tccacagtct tcaacaccgt ggtcaggagg gggcaggaat
     8881 cctctccaac gatcaaggac aactgaagcg ccatcgtgac atggggcttt tatcagaagt
     8941 tttcagaaat ccagctaatt tggataaatt gacaggagct ggtgcgattg ggcatgtgcg
     9001 ttatgcgact gctggcgaag cttctgtaga taacatccag cccttcctct tccgttttca
     9061 cgatatgcag tttggcttgg ctcataatgg aaatctgacc aatgcagcct ctctcaagaa
     9121 agaactggaa caaagaggag caattttcag cgcgacttcg gactctgaaa tcttggctca
     9181 cctcattcgt cgcagtcata atcctagcct gatgggcaaa atcaaggaag cgctcagcct
     9241 tgtcaaaggt ggttttgcct atatcttgct gtttgaggac aagttgattg cggctcttga
     9301 ccctaatggc tttcgtccgc tttctatcgg gaaaatggcc aacggagcgg tggttgtttc
     9361 ctctgaaacc tgtgcttttg aggtcattgg tgccgagtgg attcgtgatt tgaagccagg
     9421 tgagattgtg atcattgatg acgagggcat tcagtatgac agctatacag atgataccca
     9481 gttggcgatt tgttctatgg agtatatcta ctttgctcgc cctgattcta atatccacgg
     9541 tgtcaatgtc catacggcac gtaagagaat gggagcgcaa ttggcgcgag aatttaagca
     9601 tgaggcagat attgtagttg gtgtgcccaa ttcttcccta agcgcggcta tgggatttgc
     9661 ggaagaatca ggcttaccaa atgaaatggg tctgatcaaa aaccaataca cccagcgaac
     9721 ttttatccaa ccgactcaag aattgcggga gcaaggagtg cggatgaaac tgtctgctgt
     9781 ttcgggtgtt gtcaaaggca aacgtgtggt catggtggat gattccattg tacgtggaac
     9841 aacctctcgt cgtatcgttc agctcttgaa agaagcgggt gcgactgagg ttcacgttgc
     9901 cattggaagt cctgcactag cgtatccatg tttctacggg attgatatcc agacccgtca
     9961 ggagctgatt gcagccaatc atacggtcga agaaactcgc caaatcattg gtgcggacag
    10021 tctgacttat ctttcaattg atagcttgat tgagtcgatt ggtatcgaaa cagatgcgcc
    10081 gaacggtggt ctctgtgtcg cttactttga cggtgactac ccaacgcctc tctatgacta
    10141 cgaagaagac tatcgtagaa gtttggaaga aaagaccagt ttttacaagt aggcgacaga
    10201 ttctccatta aagaaaagga aaaaacaaat gacaaataaa aatgcatatg cccagtcggg
    10261 tgtggatgtt gaagcgggtt atgaagttgt tgaacggatt aaaaagcacg tggcccgtac
    10321 ggagcgtgca ggtgtcatgg gagctcttgg tggctttggt ggtatgtttg acctttccaa
    10381 gactggggtt aaagaacccg tcttgatttc agggactgac ggtgtcggaa ccaagctcat
    10441 gttggctatc aagtacgaca agcacgatac catcgggcag gactgtgtgg ccatgtgtgt
    10501 caacgacatc attgctgcag gtgcggaccc cctctatttt ctcgactacg tagcgacagg
    10561 gaagaatgaa ccagctaagc tagaacaagt ggttgctggt gtggcagaag gttgtgtgca
    10621 ggctggtgct gccctcatcg gtggggaaac ggctgaaatg ccgggcatgt acggcgaaga
    10681 cgactatgac ttggctggtt ttgcggtcgg tgtggctgaa aaatctcaaa tcattgacgg
    10741 ttcaaaggtg gtagagggag atgttcttct cggacttgct tcaagtggga ttcactcaaa
    10801 tggttactct ttggttcgtc gtgtctttgc ggattacaca ggtgaggaag tcctaccaga
    10861 attggaaggc aagaaactta aggaagttct acttgagccg actcgtatct atgtcaaggc
    10921 tgtcttgccg ctcatcaaag aagagttggt caacggcatt gcccacatca caggtggtgg
    10981 ctttatcgaa aatgtccctc gtatgtttgc agatgaccta gctgctgaaa ttgatgaaag
    11041 caaagttcca gtgcttccaa ttttcaaagc ccttgaaaaa tatggtcaga ttaaacacga
    11101 agaaatgttt gaaatcttca atatgggtgt gggacttatg ttggcggtca gccctgaaaa
    11161 tgtagagcgt gtaaaagaat tgttggatga agcagtctat gaaattggtc gcatcgtcaa
    11221 gaaagaaaac gaaagtgtca ttatcaaatg aaaaaaatag cggtttttgc ctctggtaat
    11281 ggctcaaatt ttcaggtgat tgccgaagaa tttccagtgg agtttgtctt ttcagaccat
    11341 cgtgatgcct atgtgcttga gcgtgcaaag cagctcggcg ttctgtccta tgcttttgaa
    11401 ctcaaggagt ttgagagcaa gacagactac gaagcagccc ttgtcgaact cttggaagaa
    11461 caccagattg acttggtttg cctagcaggc tacatgaaaa tcgttggacc aaccttattg
    11521 tcggcttatg aaggtcggat tgtcaacatt catccagcct acttgccaga atttccagga
    11581 gctcatggga ttgaggatgc ttggaatgct ggcgtgggtc agtctggtgt gaccattcac
    11641 tgggtggatt cgggtgtgga tacaggccag gtcatcaaac aggttcgtgt gccacgacta
    11701 gctgatgata ccattgacag atttgaagct cgcatccatg aagcagagta caggttgtat
    11761 ccggaagtag tgaaggctct atttacagat tgactttttg atgattcata tgatatcttt
    11821 gattttaaat tggagtcagt gtttgttgaa gacggcttca aacggaggta tttgtaatgt
    11881 tagaatctaa aaaaacaact cgatatgtat tttatgtcta tctgatgtta ttaacttggg
    11941 gaatcttatt taagtttgaa acaaatcctg aatttatagc atttttctta gctccaaggt
    12001 atatcaattg gattccattt tcagaaccac taatagtcga tggaaaaatt gtttttgctg
    12061 aaatgttatt taatctgatt tcctttattc cattaggtgt ttgtttccct ttgataaaaa
    12121 ctaatttatc tagtttaaga atagtcggga caggtttctt gattagttta ttgtttgagt
    12181 gcttacagta tattttagca ataggtataa cagatataac ggatttgact ttaaatacgc
    12241 taggtgtctg tgtaggctta ctgatttatc aaatttttat aagagtgttc aaatcacaga
    12301 ctagaaaatg gatcaatatc ttaggtatgc ttagccttgg ttttgcttat cttgttttac
    12361 tgttactgca tttaattggt gtttaactaa tgattaaaaa ggagaatata atgactaaac
    12421 gcgtcttaat cagcgtctca gacaaagcgg gcattgttga atttgcccaa gaactcaaaa
    12481 aacttggttg ggagattatc tcaacaggtg gaactaaggt tgcccttgat aatgctgggg
    12541 tggataccat tgctatcgat gatgtgactg gtttcccaga aatgatggac ggtcgtgtga
    12601 agaccctcca cccaaatatc cacggagggc ttctcgctcg tcgtgacttg gatagccact
    12661 tggaagcggc taaggacaac aagattgagc tcattgacct tgtggtggtc aacctttacc
    12721 catttaagga aactatcctt aaaccagatg tgacttatgc tgatgcagtt gaaaatatcg
    12781 atattggtgg gccgtctatg cttcgttcag cagcgaaaaa tcatgccagt gttacagttg
    12841 tggtagatcc tgctgactac gctgtggttt tggacgaatt ggcagcaaac ggcgaaacct
    12901 cttatgaaac tcgccaacgt ttagcagcca aagtatttcg tcacacagcg gcttatgacg
    12961 ccttgattgc agaatacttc acagctcaag tgggtgaaag caagcctgaa aaactcactt
    13021 tgacttatga cctcaagcaa ccaatgcgtt acggtgagaa tcctcaacaa gacgcggact
    13081 tttaccagaa agctttgcct acagattact ctattgcttc agccaaacag ctcaacggga
    13141 aagaattgtc atttaataat atccgtgatg cagatgctgc tatccgtatc atccgtgact
    13201 tcaaagatag tccaaccgtt gtggctctca aacacatgaa tccatgtgga attggtcaag
    13261 ctgatgacat cgagactgct tgggactacg cttatgagtc tgacccagta tctatctttg
    13321 gtgggattgt cgtcctcaac cgtgaggtgg atgctgcgac agctgagaag atgcacggcg
    13381 ttttcctcga aatcatcatt gcaccaagct atacggatga agcgctagct attttgatca
    13441 ataaaaagaa aaacttgcgt atccttgcct tgccatttaa tgctcaagag gctagcgaag
    13501 tggaagcaga atacacaggt gtagtcggtg gacttctcgt gcaaaatcaa gacgtggtca
    13561 aggaaagccc agctgactgg caagtggtga ccaaacgtca gccaactgag acagaagcga
    13621 ctgctcttga gttcgcttgg aaggctatca agtacgtcaa atcaaatggt attatcgtga
    13681 ccaacgacca catgacactt ggtgttggtc caggtcaaac caaccgtgtg gcttctgttc
    13741 gccttgccat tgaccaagcc aaagatcgtc tgaacggggc ggtccttgct tcagatgcct
    13801 tcttcccatt tgcggataac gtggaagaaa tcgccaaagc aggaattaag gccatcatcc
    13861 agcccggtgg ctctgtccgt gaccaagaat ccatcgaagc agcggataaa tacggcttga
    13921 ctatggtctt tacaggtgtg agacatttta gacattaaga agataaaagg gaagaaaaca
    13981 gtttctttcc ttttttggct taaaatgcta actgaaacaa gattaaaacg aacttttttg
    14041 atataatgtt ggtaaataat tcgcaaaaga ggttgaggaa tgaaactgct tgttgtcggt
    14101 tctggtggtc gtgagcatgc gattgctaaa aagttacttg aatcaaaaga cgtggaaaaa
    14161 gtctttgtag ctcctgggaa tgatgggatg actctggatg gtttggaatt ggtaaatatc
    14221 tctatttccg aacattctaa attgattgac ttcgcaaaga ccaatgatgt tgcttggacc
    14281 tttatcggtc cagatgatgc ccttgctgct ggtatcgtgg atgattttaa ccaagctggg
    14341 cttaaggcct ttggtccgac tagggctgca gcggagctgg agtggtccaa ggattttgcc
    14401 aaggaaatca tggtcaaata tggtgtttcg acagcagcct atggcacatt ttcagatttc
    14461 gaggaagcca aggcctatat cgaaaagcat ggtgcgccta tcgtagtcaa ggcggatggc
    14521 ttggcgcttg ggaagggtgt cgtcgttgct gagacggttg agcaagcggt cgaagccgct
    14581 catgagatgc ttttggacaa taaatttggt gactcaggtg cgcgcgtggt tattgaggaa
    14641 ttccttgaag gagaggaatt ttcactcttt gcctttgtca atggtgataa gttctacatc
    14701 atgccaacgg ctcaggacca caaacgtgcc tacgatggcg acaaagggcc taacacgggt
    14761 ggtatgggtg cctatgcgcc agttccacac ttaccacaga gtgtagttga tacagcggtt
    14821 gacaccattg tcaagccagt tctagaaggg atgattaaag aaggtcgccc ttatctaggt
    14881 gtcatttacg cagggcttat cttgacagca gacgggccga aggtcatcga gttcaactct
    14941 cgatttggag atcctgaaac tcagattata ttgcctcgtt tgacctctga ctttgctcaa
    15001 aatatcacag atatcctgga tagcaaggag ccaaatatca tgtggacgga caagggtgtg
    15061 actctgggtg tggttgtcgc atccaagggc tacccgctag actatgaaag gggcgttgag
    15121 ttgccagcca agacagaagg cgatgtcatc acctactatg caggggctaa gtttgcggaa
    15181 aatagcagag cactgctctc aaacggcgga cgagtttata tgctggttac cacagtagcc
    15241 accgtcaaag aagcccaagc cagcatctac caagaactat cccaacaaaa aatagaagga
    15301 ctcttctacc gaacagatat cggaagcaag gcaattaagt aaagatataa gaataacgcg
    15361 ccgtagtcgc caaacacgat aatggtcgtc gtggtgaaaa gaccagaaca gtgaatgttc
    15421 tggtcagggg gaaacttgga gaccgtaggc tcaaagttta ggaatgaaac cgaaggtttg
    15481 cttccgcctc catcacctaa gaccattatc aaaaagaaaa ataaaaattc acaaaatacg
    15541 ttaatgatcg tatggtttgc gagcgttagc gagctaatat agaacaatca ccgccgttgt
    15601 gaaagaacga ttggatgata atccaatcgt tcagggaaat tggaagacct tgggtttcca
    15661 atttaggcat gagacacctt tggtggctgc tgccgtccct cacaagctaa ggtgattgtt
    15721 gaaaaagagg aaaaaggaga agaaatgaaa ccagtaattt ccatcatcat gggctcaaaa
    15781 tccgactggg caaccatgca aaaaacagca gaagtcctag accgcttcgg tgtagcctac
    15841 gaaaagaaag ttgtttccgc acaccgtaca ccagacctca tgttcaaaca tgcagaagaa
    15901 gcccgtagtc gtggcatcaa gatcatcatc gcaggtgctg gtggcgcagc gcatttgcca
    15961 ggcatggtag ctgccaaaac aacccttcca gtcattggtg tgccagtcaa gtctcgtgct
    16021 cttagtggag tggattcact ctattctatc gttcagatgc cgggtggggt gcctgttgcg
    16081 accatggcta tcggtgaagc tggagcgact aacgcagctc tctttgccct ccgtctcctc
    16141 tctgtagaag ataagtccat tgcggatgca cttgccaact ttgctgaaga acaaggaaaa
    16201 atcgcagagg agtcgtcaaa tgagctcatc taaaacaatc ggaattatcg gtggcggtca
    16261 actgggtcag atgatggcca tttctgctat ctacatgggc cacaaggtta tcgcgctgga
    16321 tcctgcggcg gattgcccgg cctctcgcgt ggcggaaatc attgtggcac cttataacga
    16381 tgtggacgcc ctccgtcagt tggcagaccg ttgcgatgtc ctcacttacg agtttgaaaa
    16441 tgtcgacgct gacggtttgg atgccgttat caaggatgga caactccctc aaggaacaga
    16501 tctgctccgc atttcgcaaa atcgtatttt tgaaaaggac tttttgtcaa acaaggctca
    16561 agtcactgtg gcaccctaca aggtcgtgac ttctagccta gacttggcag atatcgactt
    16621 gtcgaaaaac tatgtcctca agactgcgac tggtggctac gatggtcatg gacaaaaggt
    16681 tattcgttca gaagcagact tggaagcagc ctatgcgcta gcagactcag cagactgcgt
    16741 cttggaagaa tttgtcaact ttgaccttga gatttctgtc atcgtgtcag gaaatggcaa
    16801 tgaggtgacg tttttcccag ttcaggaaaa tatccaccgc aacaatatcc tatctaagac
    16861 catcgtacca gcccgcattt ctgaaagtct agcagacaag gctaaagcta tggcagtgcg
    16921 aatcgcagaa caactcaact tgtctggaac tctctgtgtg gaaatgtttg cgactgatga
    16981 tgacgttatt gtcaatgaaa tcgccccacg accacataac tctgggcact attctattga
    17041 agcctgtgat ttctctcagt ttgacaccca tattctgggt gttctcggag caccattacc
    17101 agtcatcaaa ctccatgcgc cagccgttat gcttaatgtc ctcggtcagc atgtcgaggc
    17161 tgctgagcaa tatgtgacag aaaattcaag cgcccacctc cacatgtatg gtaaaataga
    17221 agcaaagcat aatcgtaaga tgggacatgt gactttgttt agtgatgtgc cggatagtgt
    17281 ggatgagctt ggggaaggga ttgattttta ggacaagtct atgatacaaa ttatcgttaa
    17341 tacatttatt gaaaaggata agactggagc agttgttgaa gtgttgtatg ccagtgctga
    17401 ccaagataag gtacaagcta aatatgaaga actagctgca caataccccg aaaattattt
    17461 agctatctat gatgtaccgc tggatacgga tttgaataca ctagatcatt acccgtctgt
    17521 gtttattgga aaagaggagt ttgagtagaa atcttggttt acctagatag cttattccca
    17581 acagcttaag aagaaaggaa aaattaacac atgatcaacc gttactctcg ccctgagatg
    17641 gcgaatattt ggagtgaaga aaataaatac cgtgcttggc ttgaggtgga aatcctctct
    17701 gacgaggcat gggctgagtt gggggaaatc cctaaggaag atgtggcttt gattcgcaag
    17761 aaggcggact ttgacatcga ccgtattttg gaaattgagc aggagacgcg ccacgatgtg
    17821 gtggctttca cgcgtgcggt ttctgagact cttggtgaag agcgcaagtg ggttcactat
    17881 gggttaactt ctactgacgt ggtggatact gcttatggtt acctctacaa gcaggccaac
    17941 gacatcatcc gtcgtgacct tgaaaacttc actaatatca tcgctgacaa ggccaaggag
    18001 cacaagttca ccatcatgat ggggcgtact catggtgtgc acgctgagcc gacaaccttt
    18061 ggtcttaaat tagcaacttg gtacagcgaa atgaaacgca atatcgagcg cttcgagcat
    18121 gcggctgctg gtgtagaagc tggtaagatt tctggtgcgg ttgggaactt tgccaatatc
    18181 ccaccatttg tagaggagta tgtctgcgat aaacttggca tccgtgccca agaaatctct
    18241 acacaagtcc ttcctcgtga ccttcacgct gagtactttg cggttcttgc cagcattgcg
    18301 acttcaatcg aacgtatggc gactgagatt cgtggtctac aaaaatctga gcaacgcgaa
    18361 gtagaagagt tctttgctaa agggcaaaaa gggtcttcag caatgcctca caaacgcaac
    18421 ccaatcggtt ctgaaaatat gactggtctg gcgcgtgtca ttcgtggtca catgattacg
    18481 gcttatgaaa acgtcgctct ctggcacgaa cgcgatattt ctcactcatc agctgagcgt
    18541 atcatcacac cagatacgac cattttgatt gactacatgc tcaaccgttt tggaaatatc
    18601 gtcaagaact tgacagtctt cccagaaaat atgatccgaa acatgaactc gacttttggt
    18661 cttatcttta gccaacgggc tatgttgaca ttgattgaaa aaggcatgac ccgtgagcaa
    18721 gcctatgact tggtgcaacc aaaaacagcc tactcttggg acaaccaagt agactttaaa
    18781 ccacttcttg aggcagattc agaagtaaca tcacgtctca ctcaagaaga aatcgatgaa
    18841 atcttcaacc cagtttatta caccaaacga gtggatgata tctttgaacg tcttggacta
    18901 ggtgattaat taaaaaataa acagcgagct tcaatctcgc tgtttatttt ttatcgaaaa
    18961 gacttagtct tcttttcttt tagtgagtcc ataggctgct agtgtggaca tgagtcctgc
    19021 gactactagt cctgcagaat cgtgagttcc tgtttcagga agttttttct ctgttaccac
    19081 aggagctgga tcttgaggaa gagctttgct ttcctcagca ggagcagttg atggagctgg
    19141 ttggcttggg atttctagtt ttggtttttc ttcagcaata gcggcttgtc cgttttcatc
    19201 gcctacatgt gttaccatag ttccgacttc gactatttga gtaacggctt cctgtgctac
    19261 gacactattt acaagtgttt tcacttcctt accatcggca gaagtgctca cagagtagaa
    19321 gttgctacga tgtccattga cgcccttagt aatgacttgt gtttttcctt tgagtaagag
    19381 tggattttca cgagtcactg tggtaaatgg aatttcttct tcttggatat ccagtctagg
    19441 ttttacctca gtagttggtg caagaccact ttcatcaccc ttgtgagtta caggagagcc
    19501 aacttcaacc acttggttta taacttcttt ggttacctgg ctatcaagga ctgtttctgt
    19561 tgtttttcca ttttcagtga gtacagagat gtaatgagtt cgttcacctt tgactcctgc
    19621 tgtgataata ttttcctgac cagctgggag gttaggattt tctttcttga taacttcaaa
    19681 tggaatttct tcagttcttg tgatgagttc tggtctggtt tcaacattgg cagccacttc
    19741 attttcatct aggcttcctg aatgagttgc agctggtttg aggccttgaa gagcggcttt
    19801 taggttggct acaagtgtgt caagctcagc ttgtttatta cggttgaggt tgtaatttag
    19861 agctgtttta gctgcgtcaa gggcctcaag actttcttta ctatatcctt ctaagtttgt
    19921 aggaatttta gctaattctt cgcggagagc attataatta gcacggaagt agtctttgtt
    19981 gtggtctgca aaggcagtca tgagttcaaa gatttcctct tccttgtact cagcgcttgg
    20041 tctatctgcc cagattgaaa gcatacttcc gactgttgga agatctactt caggatattt
    20101 ggtagaagct agttgattga atggtgtttt tccagtattc tcaatagctt tcttgaggaa
    20161 accaccacca tcttctggtt tttgaccaag aatgtagtac cagtcaccgt tggtattcaa
    20221 gaatttatag cctttgcttg ctaggtattg aggtgatgcg aggttatatc cccaccagcc
    20281 tttagaccag taagaaatca agacatcttt gtcaaactga acatcgtcct tgtcttcata
    20341 gtagaagcca tcgttgaagg ccattggttg aagccctctt tctttggcca tagctgcgag
    20401 ggtgttggca tattcggcaa atttgccata gagttgatac cacttgaggt agtaccagcc
    20461 ttgggcacta gtcgcatcgt tggcgtattc gtcagtacca aagttgaaaa tctttgtttt
    20521 acctgcaaag aagtccatgt atttaccgat gagggctttt acaaagttca tcgcttcttc
    20581 gtttttcaag tccatagttg tttttgaaac tttatcaaag tgggcttgag gatttttaat
    20641 acctaatttt tccatggcaa ccagcatagc atccatgtga cctggactgt taatagctgg
    20701 gatgagaccg atgtccttag atttagcgta ttcaattagc tctgtcactt ctgcctgtgt
    20761 tagtgcagta ccgtttggat cgtcgtagta agctttagtt ccttcgataa tagctttttt
    20821 aacgtcatca ctagcatagg tttttccgtt ggcagtaatg gtcatatcat cgagtagaaa
    20881 gcgaagtccg tcatttccta gaaggagatg gacatcagaa tatccgagct cactggcctt
    20941 gtctacgatg cgtttgagct ggttcagagt aaagtatttg cgtccagcat cgattgagat
    21001 taccttgttt ttggcaagtt tttcaacctc acgtttagct tcttcttctt tttgagcttc
    21061 aggcgtgagg gtcaagttgt tgacagtttc ttgaagttta gcaatggctt gatcaatcgt
    21121 atcttgttgg gcacggctaa ggttgctatc gagagagcga atagcttttt cagcttcttt
    21181 tacggccgcg acgctttctg cagtataacg gttcaggtct tttggtacct cgttaagtgc
    21241 ttgctctgca gattcataat cagctgcgaa gtattcagcg ttggcatttg caaaatgacg
    21301 catgagtttg aagaggcgtg atggtgaata acgtgcagat ggagtgtcag cccaagcagc
    21361 taccatacca ccgatgattg ggatatcagc tccttctgtt tttggtacag aagtgattgg
    21421 tgtgttttta ataccattga gcccctgatc gagattgtac cagccttggc catcagcgtt
    21481 tcgtccaaga acgtagtacc aagcatcatt ggtattaagg atttggtgac ctttttcagc
    21541 tagtagttta gaagaagcga catcgtagcc tccccaacca ccagtccaca tagaaacgat
    21601 gatgtctttg tcaaaactac caaagcttgt gtcgctattg tagtagatac cgtcgttaaa
    21661 ggccattggt ttgagaccgt gcgattttac aatacgagcg aggtcattgg cgtaggcaat
    21721 aaatttttca tagcctttta cagggtagcc ttcgtttgga tagtatttat cagcttgaag
    21781 cacactccaa cctttagcat ctgtcgcatc attggcatat tcatcaagtc cgatgttgaa
    21841 gatttcagtc tttttcgcga aataagcagc atacttgtcg ataagggctt ttgtaaaagc
    21901 gacagcttgt tcgttgtcaa gatcgacagt acgggctgat ttcttcccaa aatagctaaa
    21961 gttagggttt tggattccca attctttcat ggcattgaga atcgcatcca tgtgtccagg
    22021 actatttact gtcggaatga gaccgatacc tttatctttg gcatagttaa tcagatctgt
    22081 catttgactt tctgttaagt gattgccgtt tggatcgttg taataatcat ttgtaccttt
    22141 ttcaatggcg cgtttgacat cgtcactggc ataggtcttg ccgttagctg tgatgctcat
    22201 atcgtccaac atgaaacgga gtccatcatt tccgactaat aggtgtaaat cagtgtagcc
    22261 ataatgtttc gctttatcga tgatttcctt gagctgttct ggtgagaaat atttacgtcc
    22321 agcatcaata gaaacaattt tctttttcgc tagtttttca tttacagttg cagcacgttc
    22381 ctttcctgtc tctgtttccg gtttgtcagc ctctgctttc gcttcatctt ttttagctgg
    22441 tttatccttg tcagtcttgt ctgtatttga ctctttagaa tcaacctctt tcgcttcttc
    22501 ctttttaggg ctagcttctt cttccttttt attagcagtt tctttttcag cagaagttgg
    22561 agttaccacc tctgctttat cactaggagt tgaactaact tcctcttgtg gtttttcttc
    22621 tgtttttgga agactagcta ccttatcagt agctggagtt tctgtttcta cagtttttgg
    22681 agcttctgtt tctacagttt ttggagcttc tggttgaagc tctgctttag gtgtttcctc
    22741 agtccgattt tcggatgatt gaggggaatc agaaaccgta tggatggtcg gttggttttc
    22801 tgtagtagta ggagtaactc catcggctgc aacagtctgt gcttggaagg caaatccaat
    22861 tagaacagaa gctgctccta cagcgtattt acgaatagaa aaacgctgtt gtttttcatg
    22921 tttcattgca aaacctcctg attgcattgt tatattgata gcgattatat aaatcaacgc
    22981 ctttatttta tttcttatat taacgagagt caagaggaga tgacaaaaaa ctataataag
    23041 tataaaaaaa tataaaattt aaacttaaga tttcagattg gtcgaaaaaa tacatatata
    23101 tatctagtat aatttttggt tctatttcta taaaatattc cacaaattat agaatcttcc
    23161 aaaaataggt aagcgctacc tttttggtgt ggtataataa gcatagaaaa agcccgagcg
    23221 attaggctca ggctttcttc ttagtgatca cggtcacatg agatgaattt aatcttgtag
    23281 taatcagatc gtttgtaagt ttcactgtat tctaaaactt ggccagttga ttcgagtttg
    23341 gtgattttag tttgtaggac agtagggaat tgttcatcga ctccgaggac tgaagccgca
    23401 tgttctggag ttggaaagac tatttcgttg atttcttcaa agtgttcatc attcatgtga
    23461 atgtggtagt ctaacttgaa acgattatag atagaactat agtattcaag gtttggataa
    23521 tttgcgttga tatattgttc tgggatgtag gatgtatggt agatataaac gacaccgttt
    23581 gattcgcgga tacgttcaat cttgtagtag aattgatcgc cgcgtagacc caatttttcc
    23641 aagtaaacaa gcttgtttcc gcgttcaatt gaaagaacag ttaccttatc atctttagca
    23701 ttgaagagtt caatatctga aaactctaca agcttgtgtt tgcgtgcacg tgaaacgaag
    23761 gttccttttc cttgttggcg gacaatatag ccatctttgg caaggtcgtt taaggcgcga
    23821 acaactgtga tagagctgac atcgtacatt gaaatgagtt ctgcttcagt gtaaaattta
    23881 tctccactgc taaactgccc agagatgatt ttatttttta attcgtcttt tatgtattga
    23941 tatttgggaa ttgccatatt tttacctcta ttttccttct ccatagaaaa ttttaccata
    24001 aaagcgaaaa
//
LOCUS       DAVHSO010000031        23877 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.031, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000031 DAVHSO010000000
VERSION     DAVHSO010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23877)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23877)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23877
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.031"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(105..2363)
                     /locus_tag="VVR18_001233"
     CDS             complement(105..2363)
                     /locus_tag="VVR18_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEU6032760.1"
                     /translation="MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSL
                     FKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPPTQSGGGYGGNGGYGSQNRGSAQ
                     TPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
                     GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEI
                     RKREDIILFIDEIHEIVGAGSASDGNMDAGNILKPALARGELQLVGATTLNEYRIIEK
                     DAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAAIEAAATLSNRYIQD
                     RFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRD
                     QIAKYKEMQKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKS
                     HVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSA
                     DSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDEVEKAHP
                     DVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSV
                     LGELGNFFSPEFMNRFDGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKV
                     KEKLVDLGYDPKMGARPLRRTIQDCIEDTITDYYLENPSEKDLKAVMTSKGNIQIKSA
                     KKTEVKSSEKEK"
     gene            complement(2592..2822)
                     /locus_tag="VVR18_001234"
     CDS             complement(2592..2822)
                     /locus_tag="VVR18_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005592360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkuJ family protein"
                     /protein_id="HEU6032761.1"
                     /translation="MESHLVRIINRLEAMANDGGNLKRNFEREGVVVAEVAYSHDEEN
                     GPIFTLRDVEDRETYTFDSIDLIAMEIYELLY"
     gene            3013..3696
                     /locus_tag="VVR18_001235"
     CDS             3013..3696
                     /locus_tag="VVR18_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001011621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6032762.1"
                     /translation="MNFSFLPKYLPYFNYGAVVTILISICVIFLGTILGVVLAFGQRS
                     KFKPLVWLANLYVWIFRGTPMMVQIMIAFALMHINAPTIQIGILGVDFSRLIPGILII
                     SMNSGAYVSETVRAGINAVPKGQLEAAYSLGIRPKNAMRYVILPQAVKNILPALGNEF
                     ITIIKDSSLLSAIGVMELWNGATTVSTTTYLPLTPLLFAAFYYLIMTSILTVALKAFE
                     KHMGQGDKK"
     gene            3696..4430
                     /locus_tag="VVR18_001236"
     CDS             3696..4430
                     /locus_tag="VVR18_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU6032763.1"
                     /translation="MTETLIKIENLHKSFGKNEVLKGINLEIKRGEVVVIIGPSGSGK
                     STLLRSMNLLEEATKGKLIFEGVDITDKKNDLFAMREKMGMVFQQFNLFPNMTVMENI
                     TLSPIKTKGESREVAEKRSQELLEKVGLPDKADAYPQSLSGGQQQRIAIARGLAMEPD
                     VLLFDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAREVADRVIFMADGVV
                     VEDGTPEQIFEQTQEQRTKDFLSKVL"
     gene            4584..5441
                     /locus_tag="VVR18_001237"
     CDS             4584..5441
                     /locus_tag="VVR18_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000192112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="HEU6032764.1"
                     /translation="MTQIIDGKALAAKLQGQLAEKTAKLKEETTLVPGLVVILVGDNP
                     ASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPK
                     HIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKN
                     AVVIGRSNIVGKPMAQLLLAKNATVTLAHSRTHNLAKVAAKADILVVAIGRAKFVTAD
                     FVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQ
                     AALRTLDRK"
     gene            5583..6455
                     /locus_tag="VVR18_001238"
     CDS             5583..6455
                     /locus_tag="VVR18_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000864675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-hydrate dehydratase"
                     /protein_id="HEU6032765.1"
                     /translation="MKVINQTLLEKVIIERSRSSHKGDYGRLLLLGGTYPYGGAIIMA
                     ALAAVKSGAGLVTVGTDRENIPALHSHLPEPMAFSLQDQQLLKEQLEKAEVVLLGPGL
                     RDDASGENLVKQVFVNLSQNQILIVDGGALTILARTSLSFPSSQLILTPHQKEWEKLS
                     GITIEKQKEDATASVLPSFPQGTILVEKGPATRIWEVGQSDYYQLQVGGPYQATGGMG
                     DTLAGMIAGFVGQFRQASLYERVAVATHLHSAIAQELSQENYVVLPTEISRYLPKIMK
                     IICQQERVSKDKLV"
     gene            6737..7420
                     /gene="rpiA"
                     /locus_tag="VVR18_001239"
     CDS             6737..7420
                     /gene="rpiA"
                     /locus_tag="VVR18_001239"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="HEU6032766.1"
                     /translation="MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEE
                     GLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALL
                     MEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREK
                     DGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGV
                     QISTSKKGK"
     gene            7434..8645
                     /locus_tag="VVR18_001240"
     CDS             7434..8645
                     /locus_tag="VVR18_001240"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HEU6032767.1"
                     /translation="MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISK
                     TVGLNVPNMAKIGLGNIPRETPLKTVAAESNPTGYATKLEEVSLGKDTMTGHWEIMGL
                     NITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIDDFGPRQMETGELII
                     YTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRT
                     ANRRDLAVSPFSPTVLDKLNEAGIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTL
                     LKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMRENDLL
                     LITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETA
                     MIGESFLDKLV"
     gene            8647..9175
                     /locus_tag="VVR18_001241"
                     /pseudo
     CDS             8647..9175
                     /locus_tag="VVR18_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398095.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
     gene            9191..10000
                     /locus_tag="VVR18_001242"
     CDS             9191..10000
                     /locus_tag="VVR18_001242"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEU6032768.1"
                     /translation="MTFLNKIHETATFLKEKGIAAPEFGLILGSGLGELAEEIENPVV
                     VDYAEIPNWGRSTVVGHAGKLVYGELAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKV
                     LGCEGVIVTNAAGGIRFGPGTLMAISDHINMTGQNPLMGENLDDFGPRFPDMSRAYTP
                     EYRATAHEVAKKLNIKLDEGVYIGVTGPTYETPAEIRSYKTLGADAVGMSTVPEVIVA
                     AHSDLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGDFKGLLKAILAEL"
     gene            10476..11456
                     /locus_tag="VVR18_001243"
                     /pseudo
     CDS             10476..11456
                     /locus_tag="VVR18_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855254.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
     gene            11481..11993
                     /locus_tag="VVR18_001244"
     CDS             11481..11993
                     /locus_tag="VVR18_001244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001275913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin"
                     /protein_id="HEU6032769.1"
                     /translation="MSAQITINHKKARYVRIELEGYNALSLAEVEVFRFIATNAETAT
                     QVSKPVQPISQTPVKDKTLTIQHSGAYIARYSITWEEVPVDKDGNQVVRSHSWEGNGR
                     NQTAGFVLNLPIKENMRNLRVKIEKKTGLLWNRWQTIYENRPILAQPHRKITHWGTTL
                     NSKVSDDDVL"
     gene            12651..13361
                     /gene="deoD"
                     /locus_tag="VVR18_001245"
     CDS             12651..13361
                     /gene="deoD"
                     /locus_tag="VVR18_001245"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEU6032770.1"
                     /translation="MSIHIAAQQGEIADKILLPGDPLRAKFIAENFLGDAVCFNEVRN
                     MFGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNEEVHVRE
                     LVLAQAAATNSNIVRNDWPQYDFPQIASFDLLDKAYHIAKELGMTTHVGNVLSSDVFY
                     SNYFEKNIELGKWGVKAVEMEAAALYYLAAQYHVDALAIMTISDSLVNPDEDTTAEER
                     QNTFTDMMKVGLETLIAE"
     gene            complement(13384..13908)
                     /locus_tag="VVR18_001246"
     CDS             complement(13384..13908)
                     /locus_tag="VVR18_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topology modulation protein"
                     /protein_id="HEU6032771.1"
                     /translation="MKITIIGYSGSGKSTLAEKLSNYYSIPKLHMDTLQFQPGWQDSD
                     HEWMLTEIKNFLTKHKAWVIDGNYSWCYYQERMQEADQIIFLNFSPLTCLFRAFKRYL
                     KYRGKVRESMAADCPERFDWEFIRWILWDGRSKTQKENYQKLCQEYSHKATILRNQRE
                     LDQFLDKKRKSYNS"
     gene            complement(13961..14197)
                     /locus_tag="VVR18_001247"
     CDS             complement(13961..14197)
                     /locus_tag="VVR18_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HEU6032772.1"
                     /translation="MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELF
                     RAASSAIDKAETKGLIHKNKASRDKARLSAKLAK"
     gene            complement(14265..15185)
                     /locus_tag="VVR18_001248"
     CDS             complement(14265..15185)
                     /locus_tag="VVR18_001248"
                     /EC_number="2.7.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pantothenate kinase"
                     /protein_id="HEU6032773.1"
                     /translation="MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISL
                     QDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSR
                     LLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYNMEALLNFLDRIK
                     NGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIY
                     VDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNL
                     QNYIEPTRNRAEVILHKSKNHEIDEIYLKK"
     gene            15375..15742
                     /locus_tag="VVR18_001249"
                     /pseudo
     CDS             15375..15742
                     /locus_tag="VVR18_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698118.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            15958..16539
                     /locus_tag="VVR18_001250"
     CDS             15958..16539
                     /locus_tag="VVR18_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU6032774.1"
                     /translation="MYYAENPDAAHDIHELRVELLGQKMTFLTDAGVFSKKIVDFGSQ
                     LLLKCLEVNQGETVLDVGCGYGPLGLSLAKAYGVQATMVDINTRALDLARRNAEKNNA
                     KATIFQSNIYEQVEGHFDHVISNPPIRAGKQVVHEIIEKSKDFLETGGNLTIVIQKKQ
                     GAPSAKSKMEDVFGNCEILKKDKGYYILRSVKE"
     gene            16536..17813
                     /locus_tag="VVR18_001251"
     CDS             16536..17813
                     /locus_tag="VVR18_001251"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001202959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HEU6032775.1"
                     /translation="MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMA
                     VYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASF
                     GVPVAKMSGRGLGHTGGTIDKLESIRGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
                     DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELA
                     QTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELA
                     QIMLGLANVNKTVEEVHQHLENGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQ
                     ETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYT
                     NEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS"
     gene            17831..18493
                     /gene="deoC"
                     /locus_tag="VVR18_001252"
     CDS             17831..18493
                     /gene="deoC"
                     /locus_tag="VVR18_001252"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HEU6032776.1"
                     /translation="MKLNKYIDHTLLKQDAKKKQIDSLLSEAREYGFASVCVNPTWVE
                     HAKKGLEGTDVKVCTVVGFPLGATTSAVKAFETKEAIQNGADEIDMVINVGALKSGNL
                     ALVESDIRAVVEASGDKLVKVIIEACLLTDQEKVVVCQLAQKAGADFVKTSTGFSTGG
                     ATIADVTLMRETVGSDMGVKAAGGARSYADALAFVEAGATRIGTSAGVAILKGELADG
                     DY"
     gene            18480..18869
                     /locus_tag="VVR18_001253"
     CDS             18480..18869
                     /locus_tag="VVR18_001253"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEU6032777.1"
                     /translation="MATTELIELAIETSKHAYVPYSHFPIGAVLVAKDGNVYTGVNIE
                     NASYPLTNCGERTAIFKAISEGQREFSELIVYGQTEKPISPCGACRQVMVEFFEQDLK
                     VTLVAKDKSTVEMTVGELLPYSFTDLN"
     gene            18960..20012
                     /locus_tag="VVR18_001254"
     CDS             18960..20012
                     /locus_tag="VVR18_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family protein"
                     /protein_id="HEU6032778.1"
                     /translation="MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVT
                     DTGGVDDKSFNQSAWEGLQAWGKEHNLSKDNGFTYFQSTSEADYANNLQQAAGSYNLI
                     FGVGFALHNAVEEAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLAGVAAAKTT
                     KTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQY
                     AAGADIVYQVAGGTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKES
                     NFVLVSTLKQVGTTVKDISNKAEKGEFPGGQVIVYSLKDKGVDLAVTNLSEEGKKAVE
                     DAKAKILDGSVKVPEK"
     gene            20156..21691
                     /locus_tag="VVR18_001255"
     CDS             20156..21691
                     /locus_tag="VVR18_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032779.1"
                     /translation="MAHENVIEMRDITKVFGGFVANDKINLHLRKGEIHALLGENGAG
                     KSTLMNMLAGLLEPTSGEIAVNGQVVNLDSPSKAASLGIGMVHQHFMLVEAFTVAENI
                     ILGSELTKNGVLDIAGASKEIKALSERYGLAVDPSAKVADISVGAQQRVEILKTLYRG
                     ADILIFDEPTAVLTPSEIDELMAIMKNLVKEGKSIILITHKLDEIRAVSDRVTVIRRG
                     KSIETVEIAGATNADLAEMMVGRSVSFKTEKQASKPKEVVLSIKDLVVNENRGVPAVK
                     NLSLDVRAGEIVGIAGIDGNGQSELIQAITGLRKVESGSIELKGDSIVGLHPRQITEL
                     SIGHVPEDRHRDGLILEMMISENIALQTYYKEPHSKNGILNYSNITSYAKKLMEEFDV
                     RAASELVPAAALSGGNQQKAIIAREIDRDPDLLIVSQPTRGLDVGAIEYIHKRLIEER
                     DNGKAVLVVSFELDEILNVSDRIAVIHDGKIQGIVSPETTNKQELGVLMAGGNLGKEK
                     SDV"
     gene            21684..22742
                     /locus_tag="VVR18_001256"
     CDS             21684..22742
                     /locus_tag="VVR18_001256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032780.1"
                     /translation="MSKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTA
                     FGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGLPGQALAGWILSGWFALSHPDM
                     PRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFP
                     KDFMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGF
                     EIRAVGLNPHASEYAGISAKRTIILSMIISGALAGLGGAVEGLGTFQNVYVQGSSLAI
                     GFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSIVTASIIFFVSV
                     HYLIERFVKPKKQVKGGK"
     gene            22745..23701
                     /locus_tag="VVR18_001257"
     CDS             22745..23701
                     /locus_tag="VVR18_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032781.1"
                     /translation="MSIITLLPLLVSSMLIYSAPLIFTSIGGVFSERGGVVNVGLEGI
                     MVMGAFSGVVFNLEFAEQFGAATPWLSLLVAGLVGSVFSIIHAAATVHFRADHVVSGT
                     VLNLMAPALAVFLVKVLYNKGQTDNLSQTFGRFDFPVLANIPVIGDIFFKSTSLLGYL
                     AIAFSFLAWFILFKTQFGLRLRSVGEHPQAADTLGINVYKMRYLGIIISGFLGGIGGA
                     IYAQSISVNFSVTTIVGPGFIALAAMIFGKWNPIGAMLSSLFFGLSQSLAVIGSQLPF
                     LQGVPAVYLQIAPYVLTILVLAAFFGKAVAPKADGINYIKSK"
     gene            23786..>23877
                     /locus_tag="VVR18_001258"
     CDS             23786..>23877
                     /locus_tag="VVR18_001258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6032782.1"
                     /translation="MKLTYDDKVQIYELRKQGYSLEKLSNKFGI"
BASE COUNT         6962 a         4306 c         5422 g         7187 t
ORIGIN      
        1 actatatatc ataatggaca aagggcaagc tgtcaagaaa ttacagttat tttagtaaaa
       61 aaagaagcag aaaaatttca ttttctactc cttttctata ggatttattt ttctttttca
      121 gaacttttaa cttcagtttt tttggcagat ttaatctgaa tgtttccctt gctagtcata
      181 actgctttga gatctttttc gcttggattt tcaaggtagt agtcagtgat tgtgtcctca
      241 atacagtctt gaatagtccg acgaagtggg cgtgctccca tttttggatc ataacctagg
      301 tcaaccaact tttccttgac cttatcagtt acatccaaac gaatgttgtt gctagagagg
      361 cgcttgttaa catctgctag catgagctcg acaatctgaa ggaggttatc cttgctgaga
      421 gccttaaatt cgataatgcc atcaaaacgg ttcataaact ctgggctaaa gaagttaccg
      481 agttcaccga ggacagaatt ggtacgtcct tctctagcag caccaaatcc aacgctagct
      541 tcggtctttc ctgtacctgc atttgaggtc atgataatga tagcatcctt gaagctaacg
      601 gtgcgtcctt gcccgtctgt caaacgacca tcgtccaaga cttgaagaaa catgtgcata
      661 acatctgggt gagctttttc cacttcatcg agaaggatga gagaatatgg attgtggcga
      721 actttttcag ttaattgacc agcctcatca tagccaacat aacctggagg agcgccgacc
      781 aacttagcca cactatgttt ttccatgtat tcactcatat caaagcgaat catactatca
      841 gcagaaccaa aaagttcgat agccagttgt ttggaaagtt ctgtcttacc gacaccagtt
      901 ggcccaacga agaggaagct tccgattggg cggttagggg taccaagtcc gacacgatta
      961 cggcgaatag ccttggcaat cttatcgact gcatcatctt gaccaataac atgagacttg
     1021 agatcttcgg ctagatggat gagttgagat tgttctttct ctttcaaatc accaacaggg
     1081 atattggttt tctgctcgat aatgtgctca atagttttct cgctgatgat aggagtatcc
     1141 tggtctgtga tctttttctt ttgcatttcc ttatacttgg caatctggtc gcggaagtag
     1201 gccgccttct caaaatcttc ttctcgtgta gcttgagact tgagattttc agcctcaatc
     1261 aagcgctgat caattacttt aggatccaca aaattcaagg tcaagttcat cttagaacca
     1321 gcttcatcta ggaggtcaat ggccttgtca ggcaagaagc gatcttggat gtagcgattg
     1381 gaaagagttg cagctgcttc aatcgcagca tcggtatatt gaacgtggtg gtaatcttcg
     1441 tatttctttt gaatcccttt gagaatagtg attgtttcgt ctaccgttgg ttcatcgact
     1501 ttaacaggct gcatacgacg ctcgagggca gcatcctttt caatgatacg gtattcattg
     1561 agggtagtag caccgactag ttgcagttct ccacgagcaa gggctggctt gaggatattt
     1621 cctgcgtcca tattaccatc actcgcagaa ccagcaccaa caatttcatg gatttcatcg
     1681 ataaagagga tgatgtcttc acgtttgcga atttcttcca tgagtttttg catgcgttct
     1741 tcaaattgtc ctcgaatccc cgttccttga actaagctaa ccacatccag acggatgact
     1801 tgtttacctt ggagtttatg tggcacatcg ccatcgacaa ttttctgagc tagaccttcg
     1861 acaacggccg tttttccgac accaggttca ccgataagga caggattatt cttggttcta
     1921 cgattgagaa tctcgatgac acggataatc tcatcgtcgc gcccaataac gggatcaatg
     1981 tctccacgac gggcaatttc agttacatta ataccaaatt cttccagcag gcctttttct
     2041 tggctaggtg gcggagtttg agcagatcca cgattttggg aaccataacc gccgtttcca
     2101 ccgtaacctc cacctgattg ggttggggga ataggaggag tattgctaga aggtctgaaa
     2161 ttgtttagat cattgaagaa atcaccaaag ggatcgaagt cacgattgtt cagatccgtc
     2221 atacctttga agaggctatt gttaggatct gttttgataa tcttatagca gttttgacag
     2281 aggtcaattt gtttttgttt tccattgaga ttggtgtaaa gatgaattgt tgagtcgtta
     2341 attttacagt tttgacaaag catacatcta cctcatttct ttctttagcc tgacttgttt
     2401 aaaggtcaaa aatagtcaaa ttctatactc tcattataac aggattgggg tgtaaagcaa
     2461 gtaaaaagat tgaagctttg agaagttgtt acaatgaaaa tttttgtgaa tttggactat
     2521 aaaaaaatcc tatttgtgag acaaaaagga ttttacttag acatgcaggg acaatcccag
     2581 cttgttttag attagtagag aagttcgtaa atttccattg cgattaagtc aatgctatca
     2641 aacgtatacg tttcgcgatc ttctacgtca cgaagggtaa agattgggcc gttttcttcg
     2701 tcgtggctgt acgcaacttc tgcaacaaca actccttcgc gttcaaaatt acgttttaaa
     2761 tttccgccat cgtttgccat tgcttcaagg cggttgatga ttctaaccaa atgtgattcc
     2821 attttgattc tccttcattt cttatcgtta ctattttacc ataaaggagg ccaacttgac
     2881 tagaaaaaaa ctaagatttc tcgctaattc tgctagttta aagattttta aataaattgg
     2941 ataaaaaatt taaattttaa ttcaaaacat gttataatca tacagtattc tattttagaa
     3001 agcagtgtga ctatgaattt ttctttttta cctaagtatt taccttattt taactatggg
     3061 gctgttgtga cgattcttat ttctatctgt gttatctttt tgggaactat tttgggtgtt
     3121 gtcttggctt ttgggcaacg ttcaaagttt aaaccgcttg tttggttggc caacttgtac
     3181 gtttggattt tccgtgggac accgatgatg gttcaaatta tgattgcctt tgctcttatg
     3241 catatcaatg ctccgactat tcagattgga attttaggtg ttgatttttc gcgtctgatt
     3301 ccagggattt tgattatctc tatgaatagt ggtgcttatg tttcggagac tgttcgtgcc
     3361 ggaatcaatg cggttccaaa aggtcagcta gaggcggctt attcgctagg gattcgtcct
     3421 aaaaatgcga tgcgttatgt gattttgcca caagcagtca aaaatatctt gccagcattg
     3481 gggaacgaat ttatcaccat tatcaaggac agctccctct tatcagctat tggggtcatg
     3541 gagttgtgga atggggctac aacagtttct acaacaacct atctaccttt aacaccactt
     3601 ttatttgcag cattttacta cttgattatg acctctattc tgacagtagc cttgaaagct
     3661 tttgaaaaac atatgggaca aggagataag aaataatgac agaaaccttg ataaaaattg
     3721 aaaatttaca taaatctttt ggaaagaatg aagtattgaa gggcatcaac ctcgagatta
     3781 aaagaggaga agttgtcgtt atcatcggtc cttcagggag tgggaaatct accttgcttc
     3841 gctctatgaa tttgttggag gaagcaacca aggggaagct tatctttgag ggagtcgata
     3901 ttacggacaa gaagaatgac ctgtttgcca tgcgtgagaa gatgggcatg gttttccaac
     3961 aatttaacct ctttcctaat atgactgtga tggaaaatat taccttgtca cctatcaaga
     4021 ctaaaggtga aagcagggaa gttgctgaga agagatccca agagcttttg gaaaaagtgg
     4081 gtttgccaga taaggcagac gcttatccac agagtctgtc gggtgggcaa caacaacgga
     4141 ttgccatcgc gcgtgggttg gctatggaac cagatgtttt gctctttgac gaaccaactt
     4201 cagccttgga tcctgaaatg gtaggtgagg tattggctgt tatgcaagac cttgccaagt
     4261 cagggatgac tatggttatc gtaacacatg agatgggatt tgcccgtgag gtggcagatc
     4321 gtgttatctt tatggcagac ggtgtggttg ttgaagatgg gacacctgag cagatttttg
     4381 aacaaaccca agaacaacgg actaaagatt tcttgagtaa ggttttataa tctattttaa
     4441 aatttcaaga caagattagt gaaaagttca accagagctt tttcttatag tttgaaacta
     4501 taggataacc taggaaagaa gtgttagagg gcactagcag tttttggtat aatggaagat
     4561 atttgaaaga aaagagaagt gatatgacac agattattga tgggaaagct ttagcggcca
     4621 aattgcaggg gcagttggct gaaaagactg caaaattaaa ggaagaaaca actctagtgc
     4681 ctggtttggt agtgattttg gttggggata atccagccag ccaagtctac gttcgcaaca
     4741 aggagaggtc agctcttgcg gctggttccc gtagcgaagt agtgcgagtt ccagagacca
     4801 ttactcaaga ggaattgtta gacctgattg ctaaatataa tcaggatcca gcttggcatg
     4861 ggattttggt ccagttgcca ttaccaaaac atatcgatga agaggcggtt ttattagcca
     4921 ttgacccaga aaaggatgtg gatggtttcc atcccctaaa catgggacgt ctttggtctg
     4981 gacatccagt catgattccc tcgacacctg caggaattat ggaaatgttt catgaatatg
     5041 ggattgactt ggaaggtaaa aatgcggtcg taatcggtcg ttcaaatatc gttggaaaac
     5101 ctatggctca gcttcttttg gctaaaaatg cgacagtaac cttggcccac tcacgaactc
     5161 ataatcttgc caaggtggct gctaaagcag atattcttgt agtcgcaatc ggccgcgcca
     5221 agtttgtgac tgctgacttt gtcaaaccag gtgcggttgt cattgacgtt gggatgaatc
     5281 gagatgaaaa tgggaagctc tgtggagatg ttgattatga ggcagttgca ccacttgcta
     5341 gccatatcac gccagtccct ggaggtgtcg gtcctatgac cattaccatg ctgatggagc
     5401 aaacttatca agcagcactt cggacattgg atagaaaata agagaaacat tcgattaata
     5461 gagtgtattt tctatagcta tatctaaaat ggcagaaatg aatattaaat tttagatata
     5521 agattacaaa aggaggtctg cgtctccttt ttattgtata ataaaagtga gaggaaaaaa
     5581 gaatgaaagt gattaatcaa accttattag aaaaagttat tattgaacgt tctcgttcaa
     5641 gtcataaagg agattatggt cgtctgctgc tgcttggtgg tacttatcct tatggaggtg
     5701 ccatcatcat ggctgcttta gcagctgtaa aaagcggtgc aggattggtg accgttggaa
     5761 cggacaggga aaatatcccg gctctgcaca gccatttacc tgagcctatg gccttttctc
     5821 ttcaagacca gcaattgtta aaagagcaat tggagaaggc agaagttgtc ttgctggggc
     5881 ctggtttacg agacgatgct tctggagaaa atctagtaaa acaggtcttt gttaatttaa
     5941 gccaaaatca gattttgatt gtagatggag gtgccttgac cattcttgct aggacaagtt
     6001 tgtcatttcc ctcaagccag cttatcctaa ctcctcacca aaaagaatgg gaaaaattat
     6061 ctggaattac gattgaaaag caaaaggaag atgcaacggc tagtgttctg ccttctttcc
     6121 ctcaaggaac aattttggtg gagaaaggcc cagctactcg tatttgggaa gttggccaat
     6181 ctgattatta ccagttacag gttggtggtc cttatcaggc gactggggga atgggagata
     6241 ctctggctgg gatgatcgca ggatttgtag gccaattccg acaggccagt ctctacgagc
     6301 gtgtggcagt agcgacccat cttcattcag ccatagccca agaactatct caagaaaatt
     6361 atgtggtctt accgacggaa atcagcaggt atcttcccaa aataatgaaa attatttgtc
     6421 aacaagagag ggtaagcaaa gataaacttg tttaaaatag acagataaat ctatttcctt
     6481 ctcttaattt atgattcttg aaatgcgcct gctttaaggc taaactagac gtatcaaagt
     6541 taagattttg tttttgtaac tggaaagaga tgaacaaatc aaatacataa aagataaact
     6601 catttttatt cgtttggtga aaagaaaata catattttta aagaaagatt gatgaaaaat
     6661 gtagatttga tgtttttact tgaataaaaa gcggtttcat agtaaaataa gaactgagaa
     6721 tgatggaggt aaatcggtgg aaaatctgaa gaaaatggca ggtatcaagg ctgctgagtt
     6781 cgtgagcgat ggaatggtcg ttggacttgg aacaggctcg actgcctatt attttgtcga
     6841 agaaatcggt cgtcgtatca aggaagaagg attgcagatt acagctgtaa caacttctag
     6901 tgtgaccact aaacaggcag aaggccttaa tatcccgctc aagtctattg accaagtaga
     6961 ctttgtcgat gtgacggttg atggcgcgga tgaagtggat agtcagttta atggaatcaa
     7021 aggcggtggt ggtgcccttc tcatggaaaa ggtggtcgca acaccatcaa aagaatacat
     7081 ttgggtggtg gatgaaagca agctggtcga aaaactaggt gcttttaaat tgccagtaga
     7141 agtggttcag tatggtgcag agcaggtctt tcgtcatttt gaacgagctg gctacaaacc
     7201 aagtttccgt gaaaaagacg gccaacgttt tgtgacggat atgcagaatt ttatcattga
     7261 cctcgccttg gatgtcattg aaaatccaat tgcttttgga caagaattgg accatgtcgt
     7321 tggtgttgtg gagcatggtt tattcaacca aatggtggat aaggtcatcg ttgctggacg
     7381 agatggagtt cagatttcaa cttcaaaaaa aggaaaatag aagggggcat aagatgtcta
     7441 aatttaatcg tattcatttg gtggtactgg attctgtagg aatcggtgca gcaccagatg
     7501 ctaataactt tgtcaatgca ggggttccag atggagcttc tgacacactg ggacacattt
     7561 caaaaacagt tggtttgaat gtcccaaaca tggctaaaat aggtcttgga aatattcctc
     7621 gtgaaactcc tcttaagact gtagcagctg aaagcaatcc aactggatat gcaacaaaat
     7681 tagaggaagt atctcttggt aaggatacta tgactggaca ctgggaaatc atgggactca
     7741 acattactga gcctttcgat actttctgga acggatttcc agaagaaatc ctgacaaaaa
     7801 tcgaagaatt ctcaggacgc aaggttattc gtgaagccaa caaaccttat tcaggaacgg
     7861 ctgttatcga tgattttgga ccacgtcaga tggaaactgg agagttgatt atctatactt
     7921 cagctgaccc tgttttgcag attgctgccc acgaagatat tattcctttg gatgaattgt
     7981 accgtatctg tgaatacgct cgttcgatta cccttgagcg tcctgccctt cttggtcgca
     8041 tcattgctcg cccttatgta ggtgaaccag gtaacttcac tcgtacggca aaccgtcgtg
     8101 acttggctgt atctccattt tccccaactg ttttggataa attgaatgag gctggtatcg
     8161 atacttatgc tgtgggtaaa atcaacgata tctttaacgg tgctggtatc aaccatgaca
     8221 tgggtcacaa caagtcaaat agtcatggaa ttgatacact attgaagact atgggacttg
     8281 ctgagtttga aaaaggattc tcattcacaa acctagttga ctttgatgcc ctttacggcc
     8341 atcgtcgtaa tgctcacggt taccgtgatt gcttgcatga gtttgatgaa cgcttacctg
     8401 aaattatcgc agctatgaga gagaatgacc ttctcttgat tactgcggac catggaaatg
     8461 acccaacgta tgcaggaacg gatcacactc gggaatatat tccattgttg gcctatagcc
     8521 ctgcctttaa aggaaatggt ctcattccag taggacattt tgcagatatt tcagcgactg
     8581 ttgccgataa ctttggtgtg gaaactgcta tgattgggga aagtttctta gataaattgg
     8641 tataagatga cgcgctatgc tttgctggtg agaggtatca atgttggtgg taagaataag
     8701 gtcgtcatgg cggagcttcg tcaagaattg acaaacttgg gactggaaaa ggttgagagc
     8761 tacatcaaca gtggcaatat tttctttact tcgatagatt ccaaagccca attggttgaa
     8821 aagctagaga ctttctttgc agtccattat ccatttattc agagcttttc tttactgagt
     8881 ctagaggact ttgaggcgga acttgaaaat ctaccagctt ggtggagcag agacttggca
     8941 cgaaaagatt ttctctttta cactgagggt ttggatgtgg accaagtcat cgcgacagtt
     9001 gaaagtttag agctgaaaga tgaagtgctt tattttggaa aacttgggat tttctgaaga
     9061 atcctattct aagactgcct atcataagta cttgctgaag gtgcctttct accgccacat
     9121 tactattcgt aatgctaaaa cctttgacaa aattggtcaa atgctaaaaa aataataaag
     9181 gagacacaca atgacatttt taaacaaaat ccatgaaact gctactttcc tgaaagaaaa
     9241 gggaattgca gcccctgagt tcggtctaat ccttggatca ggacttggag aattggcaga
     9301 agaaatcgaa aatccagttg tagtagacta tgctgagatt ccaaactggg gccgttcaac
     9361 agtagtcggt catgctggta aattggtata tggtgaactg gcaggtcgca aggtcttggc
     9421 tcttcaaggt cgtttccatt tctatgaagg gaatcctctg gaagtggtga ctttcccagt
     9481 tcgtgtgatg aaagttcttg gatgtgaagg tgttattgta accaatgcag ctggcggtat
     9541 cagatttggt cctggtacct tgatggctat ctcagaccat atcaacatga cggggcaaaa
     9601 tccattgatg ggtgaaaact tggatgactt tggcccacgt ttcccagata tgtctagggc
     9661 ctacacacca gaataccgtg ccactgccca tgaagtggct aaaaaactta atatcaagct
     9721 tgatgaaggt gtctatatcg gagttactgg tccgacttat gaaacaccag cagaaattcg
     9781 ttcctataag acactgggag cagatgcagt tggtatgtct acggttcctg aagttatcgt
     9841 ggcagcccac tctgacttga aagttctggg aatttcatgt atcactaact ttgcggctgg
     9901 tttccaagaa gaactcaatc acgaagaagt tgtagaagtg actgaacgtg ttaaaggtga
     9961 tttcaaaggc ttgcttaaag cgattcttgc tgaattgtaa gaaaaaagat ttaaaagggg
    10021 tagtgcctct gtcttttcag gattgactgc ctatccggat taaagaagaa acagaggaat
    10081 actatgagct tcttcctgct cttataactg aaagaagcgg aagaataggt atgtctgatc
    10141 tgatagccag cattgtgaaa gacaagattc taggatacta gcattagctt cctagccaag
    10201 cagactagta tgataaggag agatgagaat gaattgactt tctgaatttc tcagtcttat
    10261 catatatagc acaatgagat ttcgcttgag tctgcttgta aataaacgaa aagaaagata
    10321 agaaataatg aaaattggtc aacgaattat gcgctttggc ataaaaaatt aagtatcgga
    10381 gttgtatctg ttgtagtcgg ctttgatttc tagctccagc tggaatttca gccaatgaag
    10441 taaagcaaga tgtaacatct gaagtggtaa taggtgtgct agattctaag gaggaattga
    10501 aagagtcaga aaatgatgct ccaaaactag aaactcctct tagagaggag ccaagactag
    10561 ctcctcaaac gcttccggaa gcaagtgaag ttcttgaaaa caaaagggaa gagtcaaaag
    10621 tagagataac ataaccagct caagcggatg atatccgcaa ggttgttggg gaattagcca
    10681 aggatataag tattactaag ttgtatatga caggtcattc tcttggatgt tacctagctc
    10741 agattgcagc ggttgaagct taccaaaaat atcctgattt ttataaccat gtattgagga
    10801 aagtgacaac tttcagtgct cctaaagtga ttacttccag aactgtttgg aatgctaaga
    10861 atggtttctg ggatgttggt ttggaaagtc gtaaattagc tgttagtgga aaaattaagc
    10921 attatgtggt tgataatgac aatgttgtga ctcccttgat tcataataat cgtgatattg
    10981 ttacatttac aggtaattca cgctttaaac accgttctcg tggctatttt gaaagtccaa
    11041 tgaatgatat tcctaacttt aatattggta aacaagctac cttggataaa catggttatc
    11101 gtgatccgaa attggataaa gtgcgattct ttaagaaaca ggctctacct caatcttcta
    11161 gtcaaccaag cgctgaacca atggaaaata ttgccttagg aaaacaggtt actcaaagtt
    11221 cgacagcttt cggaggagat gctagaagag ctgtggatgg caaagtcgat ggtaactatg
    11281 gtcacaattc tgtcactcat acaaacttcc aatctaagcc ttggtggcaa gtagatttgg
    11341 ctaaagaaga aaccattcgc caaatcaata tttacaaccg aacagacact gcccaggata
    11401 gattggcaaa ctttgatgtc attcttttag acagttctgg taaagaaatt gagtgaaaac
    11461 gcataatatc tcctaaagat gtgtcagcac aaattacgat taaccataaa aaagcgcgct
    11521 atgttcggat tgagctagaa ggctataatg ccctcagtct tgcagaagtt gaagttttcc
    11581 gctttatagc tacgaatgct gaaacggcga cacaagtttc taagccagtt caaccaatca
    11641 gtcagactcc tgtgaaagat aaaacattga caattcaaca cagcggagct tacattgccc
    11701 gctactccat aacttgggaa gaagttccag tagataaaga tggaaaccaa gttgttcgta
    11761 gtcattcttg ggaaggaaac ggtcgcaacc agactgcagg ttttgtcctc aacctcccaa
    11821 tcaaagaaaa tatgagaaat ctgcgagtta agattgagaa aaagacaggt ctactatgga
    11881 atagatggca aacaatctat gaaaacagac caattttagc tcaaccccac cgtaaaatta
    11941 cccattgggg tacgacattg aattccaagg tgagtgacga tgatgtcttg taatctgatg
    12001 gtagaatgac agttagtttg tctagtttat aagaaagtac tacctgagct tgaatagaac
    12061 tcaggtagct ctctatgaaa gaacaaaatt aatactcaat gaaaatcaaa gagcaaacta
    12121 ggaaactagc cgcaggttgc tcaaagcact gctttgaggt tgtagataag actgacgaag
    12181 tcagtcacat atataatcca aggcgacgtt gacgtggttt gaagagattt tcgaagagta
    12241 taaacagaaa ggtagagcgc gtgttctaat ttgaacacga gtagaaaact tttctaaaaa
    12301 caaaaacgaa aggatgggta aactgtattc gctgaactga atacgggcga ctctcctcta
    12361 aatcaaaatt aagaaagaaa ggaattgaac ccaccctaaa agcagtggga aaaagatagt
    12421 tggtctagcg agcatcgctc actgcgccca actcctattt tcccttcgct ttttgacggg
    12481 tttggtatct ttctcaatat aaaatataaa ataaagaaag gtagagcgtg tgttttgatt
    12541 tgaacacgag cggaaaactc ggaaaataga taatctgact gaaaaatcag gatttctcgt
    12601 cagcttccta attttcagtc gttttcttct cgctctttgt atcataaatt atgtctatcc
    12661 atattgctgc tcagcagggt gaaattgctg ataaaattct tcttcctggg gatcctcttc
    12721 gtgctaagtt tattgcggag aatttccttg gtgatgctgt ttgttttaac gaagtgcgta
    12781 acatgtttgg ttacactggt acttacaagg gtcaccgtgt atctgtcatg ggaactggga
    12841 tgggaatgcc atctatttcg atttatgcgc gtgagttaat cgtagactac ggtgtgaaga
    12901 aattgattcg tgtgggaact gcaggttctt tgaatgaaga ggttcatgtt cgtgaattag
    12961 ttttggcgca ggcggctgca accaactcaa acatcgttcg taatgactgg ccacagtacg
    13021 attttccaca aattgctagc tttgatttgc ttgataaagc ctaccatatt gccaaagaac
    13081 ttggtatgac tactcacgtt gggaacgttt tgtcatctga tgtcttttac tcaaattact
    13141 ttgaaaagaa tatcgagctt ggtaaatggg gagtcaaggc tgtggaaatg gaagcagcag
    13201 ctctttacta tcttgctgcc caataccatg ttgatgcgct agctatcatg accatctctg
    13261 atagcttggt caatccagac gaagacacaa ctgcagaaga acgtcaaaat accttcactg
    13321 atatgatgaa ggttggtttg gaaaccttga ttgcagaata attatagcca aaaaggaagc
    13381 cctttatgaa ttgtaggact tccttttctt atccagaaat tgatctagct ctctctgatt
    13441 tcgaagaata gtggctttat gtgaatattc ttggcaaagt ttttggtaat tttctttttg
    13501 agttttgcta cgtccatccc aaagaatcca tctgataaac tcccagtcaa agcgttcagg
    13561 gcaatctgcc gccatacttt ctctgacttt tccacggtat ttaagataac gcttaaaggc
    13621 tctaaagaga caggtcaatg gcgaaaaatt gagaaagatg atttggtcag cttcttgcat
    13681 tcgttcttgg tagtagcacc aagaataatt accatcgatg acccaagctt tatgcttggt
    13741 gagaaagttt tttatctcgg ttaacatcca ttcgtggtca ctgtcttgcc aaccaggttg
    13801 aaattggagt gtgtccatgt gcagttttgg aatggagtag tagttagata acttttctgc
    13861 tagagttgac ttaccagaac cagaatatcc gataattgtg attttcattt tctacctttt
    13921 cctatttgga gacaaaaaaa cagcctctat ggactgtttc ttatttagca agtttagctg
    13981 aaagacgagc tttatcgcgg cttgctttgt ttttgtgaat caaaccttta gtttctgctt
    14041 tatcgatagc tgagctagca gcacggaaaa gttcttcaga tgggtttgct tcgaaagctt
    14101 ttatagcagt acgcatagct gatttttgag ctgagttctt ttcgttttgt ttaacgttca
    14161 attcagcgcg tttgatagct gatttaatgt ttgccaatgt tcttacctcc atatttacta
    14221 actataccat tatatatgaa aacttacgtt ttgacaaggg aaaattattt ttttaagtaa
    14281 atttcatcga tttcatggtt cttgctttta tgaagaatca cttctgcacg atttctggtt
    14341 ggttcaatat aattttgtag atttgtgaga ttgatactgg tccagacctg atgggcaaag
    14401 gcttccactt ccccaatcgg catctgagta aaacgataat agtagctatc agggtcgttt
    14461 tgggctagac tcagcatttt caagaaacgg tccagatacc aactttcaat atcatccact
    14521 ccagcatcta catagatgga aaagtcaaag aagtcagtga tatagagacg atcgttttgt
    14581 ggattttgaa agacattgat tccctcaaca attacaaaat cagcagcttt gacactttgt
    14641 ttctcttcgg gtacgatgtc gtaaacttca tgagaataga caggaatatc tacatcttgt
    14701 ccatttttga tgcgatccaa gaagttgaga agagcttcca tattatagct ttcaggaaat
    14761 cctttacgat ttaaaatccc ctgctcaatc aaggtttgat tgggatagag aaaaccatca
    14821 gttgtaacca actcaaccgt agcatctgta aacgtacggg acagtaggat ttgaagtagg
    14881 cgactggttg tggattttcc aacggcaaca ctcccagaaa ccccaataat aaaaggttga
    14941 gatttacttt cacgttggag gaaaattcct tttgaaaagg ctaaatcttc cttagttcgc
    15001 ttgtaaatct gaatcagatg agccaagggg agatagatat ctgtaacgtc ttggagactg
    15061 atttggtcat taaaactctt gatagattcc aattcttctt ctgtcaaagg aggtgttgtc
    15121 tttcgatgta aagattgcca agtctggcgg ctgatttttt caaaatgtaa aaattcgttg
    15181 gtcatttgtt ttcccctaga tattttgtct atcataccat aaaaagctaa aaaaataaag
    15241 cggtttcttg aatgtggtaa gtcaatggta tatagtataa gtgatcaatt tattgatgaa
    15301 ataggagata gattctactg atttataagc ttataaaggg gactttttag ttcacaactt
    15361 ataggaggtg tactatgaaa atcttaaaac gttacatatt ggaactctgt tttattttaa
    15421 gttttgcttt accttttata aaaggagcca atgcagataa tggtagatgc tttgtggaaa
    15481 cctattacgg ttttactttt ttgatggaac atgctattgt aacagctgtc tttatctgtt
    15541 cgttcttaat tgctgtctta ctaaaaaacg atgggcgaaa tggattgcga cagagggtta
    15601 tttcttccgc atgtcactag aagatttgat acgactttgg acaagtttgg aaatcctgac
    15661 acaaacgtat cagttgggct tttatctaaa cattttgttg ggaattttgt tgataataaa
    15721 gtattttaag gttaagcaat agaaataata atctgcctga ttatagatga taaacttttt
    15781 gtttttatct ggactgtgat atttatagtt ctaaatggtt tattatttat aagtgttgaa
    15841 agagattgaa gaaaatggct tcgtgactcg ctttcttcgg tctttttcgt tttattatca
    15901 atttgtaaac gatttacaat ttgagtcaaa ttatggtaaa atagtgtcat gagtaaaatg
    15961 tattatgcag aaaatcctga cgctgctcat gacattcatg agttgagagt agagttgttg
    16021 ggacaaaaaa tgaccttttt aacggatgcg ggtgttttta gcaagaaaat agttgacttt
    16081 ggaagtcaac tattgctcaa gtgtcttgag gtcaaccaag gagaaactgt ccttgatgta
    16141 ggctgtggtt acggaccttt gggtttgtcc ttagctaagg cttatggagt tcaggctact
    16201 atggttgata tcaacactcg tgccttggat ttagctcgga gaaatgctga aaaaaataat
    16261 gcaaaagcga cgattttcca gtccaacatc tatgaacaag ttgaaggaca ttttgatcat
    16321 gtcatttcca atcctcctat ccgtgcgggc aagcaagtcg ttcatgaaat cattgagaaa
    16381 agtaaagatt tcttggaaac tggtgggaat ttgacaatcg tcatccagaa aaaacaaggg
    16441 gctccaagtg ctaagtccaa gatggaggat gtgtttggta attgtgaaat ccttaaaaaa
    16501 gacaaaggat actatatcct tagaagtgtg aaagaatgag agcagttgat ttaatacaaa
    16561 aaaaacgaga cggtcaagaa ctgacttcaa gtgaaattga atggctggta gaaggctatg
    16621 tgtcaggaac tgttcctgat tatcagatgt ctgcctttgc tatggctgtt tattttaaag
    16681 gaatgacgac tcgtgaaatt tctgatttaa cgatgaatat ggttaagact gggcaagagt
    16741 ttgacctgtc agccattgat ggtgtgaaag ttgacaagca ttctactggt ggtgtcggcg
    16801 ataaggtaac cttgatttta gctcctcttg ttgctagctt cggtgtgcct gtagcaaaaa
    16861 tgagtggtcg tggtcttggc catacaggcg gaacaattga taaattggag tccattaggg
    16921 gctatcaagt agaacgtagt caagaggatt ttattcgtca ggttcaggat attggagtat
    16981 ctgtcattgg gcaatcagac cagctggtca aagcagataa gcttctctat gctcttcgtg
    17041 atgtgaccgc aactgtcgac acgattcctt tgattgcgag ttcggtgatg agcaagaaaa
    17101 ttgcggcagg ggcggatgct attttgctag acgtgactgt cggtgagggt gccttcatga
    17161 agacggttga tgaggcgcgt gagttggctc aaactatggt agatcttggt aaggttgttg
    17221 gacggaagac agtagcagtg attacggata tgagccagcc tttgggacga gcgattggaa
    17281 atcgtctgga aatacttgaa gcattggaga ttttgcaagg tcaaggacgt caggatatta
    17341 cccactttat ttgtgaattg gctcaaatta tgcttggttt ggcaaatgtt aacaagactg
    17401 ttgaagaagt tcaccaacat cttgagaatg gtcaagcact ggctaagttt gaggaaatgg
    17461 tgcaagccca aggtggagac ttggaagacc tctatcgtcc tgtaaatgta gctcatgtgg
    17521 tggaaatccc tgctcaggaa acgggtgtca tttcagctct tccagctatg gactttggtc
    17581 tttatgccat gaggctgggt gctggtcgtg cagttaagtc tgatgccttg gactatgaaa
    17641 caggaattgt ttttgaaaag aagattggag actccgttca aaagggtgaa attgttgcaa
    17701 aagtatacac aaatgaaaaa attccacctc aactagttac agatttccaa aaatgtgtta
    17761 aaataagtga tgaagtgaaa aaaatccgtg aaattgtaga aatcatctcc taaatggagg
    17821 gaaaaccgaa atgaaattaa ataaatatat agatcatacg cttttaaaac aagatgcaaa
    17881 gaaaaaacaa attgatagtt tgttgtctga ggctagagag tatggctttg ccagtgtttg
    17941 cgttaatcca acctgggttg aacatgctaa aaaagggctt gaaggcacag atgttaaggt
    18001 ttgcacggta gtaggtttcc ctttgggagc aacaacttca gccgtgaaag catttgagac
    18061 aaaagaagct atccaaaatg gtgcagatga gattgatatg gtgatcaatg ttggagctct
    18121 caaatcaggt aatttagcct tggttgagtc agatattcgc gcagtagtgg aagcaagtgg
    18181 tgataagtta gtgaaagtca ttattgaagc ttgccttctg acagaccaag aaaaagttgt
    18241 tgtttgccaa ttggcccaaa aagctggggc tgactttgtc aaaacatcta ctggcttttc
    18301 aactggtggt gctacgatag cagatgttac attaatgcgt gaaacagttg gatctgatat
    18361 gggagtcaag gctgctggtg gagctcgttc ttatgcagat gctcttgcct ttgtcgaagc
    18421 aggtgcgacc cgtatcggaa cgtcagctgg ggtagctatt ttaaaaggag aattggcaga
    18481 tggcgactac tgagttgatt gaactggcaa ttgaaaccag caaacatgcc tatgtcccct
    18541 attctcactt tcctatcgga gcagttttag tagccaaaga cggaaatgtt tacacgggag
    18601 tgaatatcga aaatgctagc tatcctttga ccaattgcgg tgagagaaca gctattttta
    18661 aggctatatc tgaaggccaa agagaatttt cagaattgat tgtctatggt caaactgaaa
    18721 aaccgatttc accatgtggt gcttgtcgcc aagtaatggt cgaatttttt gaacaagatt
    18781 taaaagtgac cttagtcgca aaagataaat cgacggtcga gatgacggtc ggggagttac
    18841 ttccatattc ttttacagac ttaaattagt ctgagtcgct ctttgagtgg caagggtctt
    18901 tgtgaccaat caatccatac ttgcaacatc gttgcacatc ttatttagga ggttcagtaa
    18961 tgaacaagaa acaatggcta ggtcttggcc tagttgcagt ggcagcagtt ggacttgctg
    19021 catgtggtaa ccgctcttct cgtaacgcag cttcatcttc tgatgtgaag acaaaagcag
    19081 caatcgtcac tgatactggt ggtgttgatg acaaatcatt caaccaatca gcttgggaag
    19141 gtttgcaggc ttggggtaaa gaacacaatc tttcaaaaga taacggtttc acttacttcc
    19201 aatcaacaag tgaagctgac tacgctaaca acttgcaaca agcggctgga agttacaacc
    19261 taatctttgg tgttggtttt gcccttcaca atgcagttga agaagcagct aaagaacaca
    19321 ctgacttgaa ctatgtcttg attgatgatg tgattaaaga ccaaaagaat gttgcgagcg
    19381 taactttcgc tgataatgag tcaggttacc ttgcaggtgt ggctgcagca aaaacaacta
    19441 agacaaaaca agttggtttt gtaggtggta tcgaatctga agttatctct cgttttgaag
    19501 caggattcaa ggctggtgtt gcgtcagtag acccatctat caaagtccaa gttgactacg
    19561 ctggttcatt tggtgatgcg gctaaaggta aaacaattgc agccgcacaa tacgcagccg
    19621 gtgcagatat tgtttaccaa gtagctggtg gtacaggtgc aggtgtcttt gcagaggcaa
    19681 aatctctcaa cgaaagccgt cctgaaaatg aaaaagtttg ggttatcggt gttgaccgtg
    19741 accaagaagc agaaggtaaa tacacttcta aagatggcaa agaatcaaac tttgttcttg
    19801 tatctacttt gaaacaagtt ggtacaactg taaaagatat ttctaacaag gcagaaaaag
    19861 gagaattccc tggcggtcaa gtgatcgttt actcattgaa ggataaaggg gttgacttgg
    19921 cagtaacaaa cctttcagaa gaaggtaaaa aagctgtcga agatgcaaaa gctaaaatcc
    19981 ttgatggaag cgtaaaagtt cctgaaaaat aatggatgga agtcatttct taggaagcgg
    20041 ccaagggccg cttttttaag agttgagaca aagtcatttt gtctcagtaa agcttgctac
    20101 tagacaaact agcaagtttt attgaaataa aataagactc tgaaaggaag agcacatggc
    20161 acacgaaaat gtcattgaga tgcgtgatat taccaaggtg tttggtggat ttgttgccaa
    20221 cgacaaaatc aacttgcacc tacgaaaagg tgaaattcat gcacttttag gagaaaatgg
    20281 ggctggtaag tccacgctaa tgaacatgtt agcaggcctt cttgaaccaa ctagtggtga
    20341 aatcgcggtc aacggtcaag ttgtcaatct cgactcccca tctaaagcag ctagcttggg
    20401 aatcgggatg gttcaccagc actttatgtt ggttgaagcc ttcacagtgg ctgaaaacat
    20461 cattttaggt agtgaattga ctaaaaatgg tgtgctagat atcgctggag ctagcaaaga
    20521 aatcaaggct ctttctgaac gttatggctt agctgttgac ccttctgcca aggtagcaga
    20581 tatctcagtt ggagcccaac aacgtgtaga aattttaaaa acactttata ggggggctga
    20641 tatccttatc tttgacgaac caacggctgt tttgactcca tcagaaattg atgagttgat
    20701 ggctattatg aaaaatcttg tcaaagaagg aaaatcaatt atcttgatta cccacaaatt
    20761 ggatgaaatt cgcgcagttt ctgaccgtgt tacagttatc cgtcgtggga aatcaattga
    20821 aaccgttgaa attgcagggg ctaccaatgc tgatttggcg gaaatgatgg taggacgttc
    20881 tgtttccttt aaaacagaga agcaagcctc taaaccaaaa gaagtggttt tgtctatcaa
    20941 agatttggtg gtcaatgaaa accgtggtgt tccagctgtt aaaaatctgt ccttggatgt
    21001 tcgtgctgga gagattgttg gtattgcggg gattgatgga aatggtcagt ctgaactgat
    21061 tcaagccatt acaggtcttc gtaaggttga atctggtagc attgagctaa aaggagattc
    21121 aattgtaggc ttgcacccac gtcagattac agaactaagt attgggcacg ttccagaaga
    21181 ccgtcaccgt gatggcttga ttttggaaat gatgatatct gaaaatattg cccttcaaac
    21241 ctactataaa gaaccacata gtaaaaatgg aattttgaat tattcaaata ttacttctta
    21301 tgctaaaaag ctgatggaag agtttgatgt tcgcgctgcc agtgaattag ttcctgcagc
    21361 tgcactctca ggaggaaatc aacaaaaagc aattattgct cgtgaaattg atcgagatcc
    21421 tgatctcctt atcgttagcc agccaactcg tgggttggat gtcggtgcca ttgagtatat
    21481 ccacaaacgc ttgattgaag agcgtgataa tggcaaggct gtccttgttg tcagctttga
    21541 attggatgag attttaaacg tctcagaccg tattgccgtt atccacgatg gtaagattca
    21601 aggtattgta tcaccagaaa caaccaataa acaagaactt ggtgtcttga tggctggtgg
    21661 aaacttggga aaggagaaga gtgatgtcta aaaaattaca acaaatttcg gttcccttga
    21721 tttctgtatt tctaggaatt ttactcggag ccattgtcat gtggatcttc ggttatgatg
    21781 ctatttgggg ctacgaagaa ttgttctata cagcctttgg cagtctgcgt gggattggag
    21841 aaatcttccg tgctatgggt cctctggtct tgattggtct tggttttgcg gttgccagtc
    21901 gagctggttt ctttaacgtc ggacttcctg gtcaggcttt ggcaggttgg attctcagtg
    21961 gttggtttgc cctgtcgcat ccagatatgc cccgtccctt gatgattcta gcaaccatcg
    22021 tgattgcctt gattgctggt gggattgtcg gagcgattcc aggtattctt agggcctatc
    22081 tagggacgtc agaggttatt gtaaccatca tgatgaacta cattgtcttg tatgtaggga
    22141 atgcctttat ccatgctttc cctaaagact tcatgcaaag tacagattcg accattcgtg
    22201 ttggggctaa tgcaacctat cagacacctt ggttggctga gttgactggt aactcacgga
    22261 tgaatattgg tattttcttt gccatcattg ccgttgcagt tatttggttc atgctcaaga
    22321 aaacaactct tggttttgaa atccgtgcag ttggtcttaa tccacatgct tcagaatatg
    22381 ctggtatttc tgccaagcgg actattatcc tatctatgat tatttcaggt gccttggcag
    22441 gtcttggtgg agctgttgaa ggtttgggaa ccttccagaa cgtctatgtt caaggttcgt
    22501 cattagctat cggatttaac ggaatggcgg ttagtttgct tgcggccaac tcaccaattg
    22561 gtatactctt tgcagccttc ctatttggcg ttctccaagt tggggctcct ggtatgaatg
    22621 cggcgcaggt accatctgag cttgtcagca ttgtaacagc gtctattatc ttctttgtca
    22681 gtgttcatta ccttatcgaa cgctttgtca aaccgaaaaa acaagttaaa ggaggtaagt
    22741 aaagatgtct attataacct tgctccccct cttggtgtct tctatgctga tttactcagc
    22801 acctctcatc tttacaagta tcggtggtgt tttctctgaa cgtggtggtg tggtaaacgt
    22861 tggccttgaa ggaattatgg ttatgggtgc cttttctgga gttgtcttta accttgaatt
    22921 tgcagaacaa tttggagcag caactccatg gctatccttg cttgtagcag gattggttgg
    22981 tagtgttttc tctatcatcc acgcagcagc gacggttcat ttccgtgcag accatgttgt
    23041 cagcggtacg gtattgaact tgatggcgcc tgccttggct gttttcttag ttaaagttct
    23101 ttataacaaa ggacaaaccg acaacctaag tcaaactttt ggacgctttg atttcccagt
    23161 cttggcaaat atcccagtga ttggtgatat cttcttcaag tcaactagtc tacttggtta
    23221 tctggcgatt gccttctcat tccttgcttg gtttattctc tttaagactc aatttggtct
    23281 tcgtctccgc tctgtcggtg aacatcctca agcagcggat accttgggaa tcaacgtcta
    23341 caagatgaga tatttaggga ttattatttc aggttttcta ggtggaattg gcggagcgat
    23401 ttatgcgcaa tcaatctcag ttaacttctc agtgacaact attgttggac ctggatttat
    23461 cgcccttgct gcgatgatct ttgggaaatg gaatccaatc ggtgctatgc tttctagtct
    23521 cttctttgga ctttcacaaa gtttggctgt tatcggttct caattgccgt ttctacaagg
    23581 agtgccagcg gtttatcttc aaattgcacc ttatgttttg acaattcttg tcttagcagc
    23641 cttctttgga aaagcagtcg caccaaaagc agatggtatc aactacatca aatcaaaata
    23701 agcatacaaa aaaacgtcag tccaatgact gaactacccc ccaaaagtta gacagaaaaa
    23761 atctaacttt tggggtgttt ttattatgaa actaacttat gatgataaag ttcagatcta
    23821 tgaacttaga aaacaaggat atagcttaga gaaactttca aataaatttg ggataaa
//
LOCUS       DAVHSO010000032        23203 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.032, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000032 DAVHSO010000000
VERSION     DAVHSO010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23203)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23203)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23203
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.032"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            465..710
                     /locus_tag="VVR18_001259"
     CDS             465..710
                     /locus_tag="VVR18_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000513491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032783.1"
                     /translation="MDIYGRKTIAMKHFFAGIGEIHFLLFLLYLSMSTSPIIGLVIGY
                     TKINLINSIIIALGMILALILVLSRVYRKYFYRDDDD"
     gene            867..1925
                     /locus_tag="VVR18_001260"
     CDS             867..1925
                     /locus_tag="VVR18_001260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032784.1"
                     /translation="MKDDQKYLLAGLYSLLVAIFYFPLIDSKGIFVSILMAVLLLYLI
                     YFIATVIHIVIIKFIRKKSFKYLVLYPFTYDGSWRFQPINLLYFPEMVRDVIPINLVQ
                     EYCQGQPYGLLKKMLKRIRLSREIALLLATIIVYFFTHRILPLSVFTFMFSYILLFVQ
                     SYLGSNTAWIGNRRLIIDDEFEKILLSKSYVKEISSARYSEYLTCEYKNLTPIILIAI
                     FENLLDSYLLQNQSEVDLDIFYKVLPLLYKEKYTMGFNYFVSLNYLLYKVGFLGIIYD
                     NEALRDLSKQYLNKNISELQDGSFEGGIQDAVASKQIVVINEFIACLNSRCMPSQYDR
                     FFYKDRPYIFSRKSPIKG"
     gene            2240..3217
                     /locus_tag="VVR18_001261"
     CDS             2240..3217
                     /locus_tag="VVR18_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032785.1"
                     /translation="MKNKRYFFDTILIILLLISTIFCVSPVFIKLDILGTPSHAILTF
                     VLAIPLFYILSQCLHTLLLLVSSIFCKLRPIYFYFIFVIIIGARKYYRILFHQLMGFS
                     PGIAVFYKESQTTKNLFKFYYFLYFTTLISYYFFFTFVYDKPLLLPLISFSIIIALVQ
                     KLYRIENQQLFLLKSKVLTILESKKNCEFNLQDYHEIWKLQSKSELPCVALSYISLIK
                     PYLSESVREQIDLLEVKRFKKINNPISLYGMLDVIKLNLYLRHYNEKNKYESMLKKIL
                     EVRPDFVLIEQNIDDSLNSSQPLSLSLAISEIQLLLEVYIGIKHVSIRR"
     gene            3594..3968
                     /locus_tag="VVR18_001262"
     CDS             3594..3968
                     /locus_tag="VVR18_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPH_0224 family bacteriocin-like peptide"
                     /protein_id="HEU6032786.1"
                     /translation="MELVLPNNYVVLEQEEMMYLDGGFSIPRWPVATAINIAFNGVLG
                     GGAISLVRNYIRNYGLRRVTSAIAGAAARYVGVRVANRVAGFALPAINGFAAWMSIGD
                     AITTIWANNDVNRRDPNLNALW"
     gene            4176..5078
                     /locus_tag="VVR18_001263"
     CDS             4176..5078
                     /locus_tag="VVR18_001263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032787.1"
                     /translation="MIRKLIVFLLMLPLFVLWLELHVLVNNLLLNLESPLDFVISMSL
                     AFCSLILSKIVLDILYALKDLYKKEGLIKIFPFIFIRRKKVNVRFSPYFSFHRKSLSP
                     DDLRSRIIWSFILEIAIILVFILKIPFAIIMLTTIFFWTIMDINHLVFNKTEFLFNQN
                     KWQKEDSFESDLTKTLKDKIQKSELSYSDLMSLQLYDAMNQSTFLTDSELFEAILGKI
                     VDSESTLLCIGLVELLLYEISISNNNNWSNKVDKIRIHLIRINQLDFFYYTSWLRQNF
                     DFCMNREYHKMKSRKLLLSNKKIV"
     gene            5134..5487
                     /locus_tag="VVR18_001264"
     CDS             5134..5487
                     /locus_tag="VVR18_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HEU6032788.1"
                     /translation="MELVLPNNYVVIDEEEMMYLDGGTYLSKRACQGICVALAMSPGT
                     FIALAGAAVLTKKLINYIKVGSFGGWLIGAAAGVLATAAGKIAYCIGYGALNRGCDIS
                     GNPYPWNGFISVTVR"
     gene            5484..6212
                     /locus_tag="VVR18_001265"
     CDS             5484..6212
                     /locus_tag="VVR18_001265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032789.1"
                     /translation="MNNVDKIRKIHIIVYWVYIFLSFRAIINDTEYFLLIFLAFIYSI
                     VSLPLYSVKNKIVSICLAINSILLMSFPILINKFFPESFLTYTVLISVFITELIIFHL
                     IGKDFATKLTNEYKKISQFRSKVSQSPWIKYLEISSFILTIFPSILYGTVDNRVLALI
                     FLIKICVDTTIKFLFIRLFDTSTLMKRRIFFLFALDVIAYLFLGYLLVIQKAGYLFSV
                     LLLFSNFSVPFIKEKEYELFKNSK"
     gene            7339..7842
                     /locus_tag="VVR18_001266"
     CDS             7339..7842
                     /locus_tag="VVR18_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032790.1"
                     /translation="MKLLDCILDYQERFNRKTCQVSTNYKYLETFKVNFCLTDLHHLF
                     GLHKITRDFASHTISVIQTGVFILEDFRNILLYNDVIERISLYEFIGDIFYSKLTSCC
                     IVAKDLSKNTMKLDVIFFEDKNKISAVLGLRRDKSGVFKPVTLYFTSAKKYAKVRKTD
                     VKEMKWL"
     gene            8128..10044
                     /gene="pspA"
                     /locus_tag="VVR18_001267"
     CDS             8128..10044
                     /gene="pspA"
                     /locus_tag="VVR18_001267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein A"
                     /protein_id="HEU6032791.1"
                     /translation="MNKKKMILTSLASVAILGAGFVTSQPTFVRAEEAPVANQSKAEK
                     DYDAAKRDAENAKKALEDAKRAQKKYKDDQKITEEKAEEEKKASQEQQKANLDYQQKL
                     RKYINEKDSKKRSMLQKEMEEAERKDKEKQAEFKKIREKVIPSAEELTETRRKAEEAE
                     AKEPELTKKVKEAEEKVTEAKQKLDAERAKEVALQAKIAELENEVHRLETKLKEIDES
                     DSEDYVKEGLRAPLQSELDAKQAKLSKLEELSDKIDELDAEIAKLEKDVEDFKNSDGE
                     YSALYLEAAEKDLAAKKAELEKTEADLKKAVNEPEKPAPAPETPAPEAPAEQPKPAPA
                     PQPAPAPKPEKPAEQPKPEKTDDQQAEEDYARRSEEEYNRLTQQQPPKAEKPAPAPQP
                     EQPAPAPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNSNGAMATGWLQNNGSW
                     YYLNANGAMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGDMATGWLQNNG
                     SWYYLNANGAMATGWAKVNSSWYYLNANGAMATGWAKVNSSWYYLNANGAMATGWAKV
                     NGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNT
                     TVDGYEVNANGEWV"
     gene            10445..11566
                     /gene="mnmA"
                     /locus_tag="VVR18_001268"
     CDS             10445..11566
                     /gene="mnmA"
                     /locus_tag="VVR18_001268"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HEU6032792.1"
                     /translation="MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDT
                     DENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVM
                     CNKEIKFKAFLDYAMTLGADYVATGHYARVVRDEDGTVHMLRGVDNGKDQTYFLSQLS
                     QEQLQKTMFPLGHLEKPEVRKLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQ
                     PGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQ
                     GFYHDSLMSTSLEASQVHFTRDMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFA
                     EPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI"
     gene            11707..12105
                     /locus_tag="VVR18_001269"
     CDS             11707..12105
                     /locus_tag="VVR18_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU6032793.1"
                     /translation="MTQQDFRTKVDNTVFGVRATALIVQNHKLLVTKDKGKYYTIGGA
                     IQVNESTEDAVVREVKEELGVKAQAGQLAFVVENRFEQDGVSYHNIEFHYLVDLLEDA
                     PLTMQEDEKRQPCEWIDLDKLEDIQLVPAF"
     gene            12172..14085
                     /gene="mnmG"
                     /locus_tag="VVR18_001270"
     CDS             12172..14085
                     /gene="mnmG"
                     /locus_tag="VVR18_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HEU6032794.1"
                     /translation="MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEML
                     AFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTA
                     LRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTE
                     IQPGDEAPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVG
                     PRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGL
                     ENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGI
                     NAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMR
                     LTEMGREIGLVDDERWARFEIKKNQFENEMKRLDSIKLKPVKETNAKVEEMGFKPLTD
                     AVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMK
                     RMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEG
                     KNRSISKTLQKSK"
     gene            complement(14464..16143)
                     /locus_tag="VVR18_001271"
     CDS             complement(14464..16143)
                     /locus_tag="VVR18_001271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEU6032795.1"
                     /translation="MAYTLKPEEVGVFAIGGLGEIGKNTYGIEYQDEIIIVDAGIKFP
                     EDDLLGIDYVIPDYSYIVDNIDRVKAVLITHGHEDHIGGIPFLLKQANVPIYAGPLAL
                     ALIRGKLEEHGLLRNAKLYEINHNTELTFKNLKATFFRTTHSIPEPLGIVIHTPQGKI
                     VCTGDFKFDFTPVGEPADLHRMAALGEEGVLCLLSDSTNAEVPTFTNSEKVVGQSIMK
                     IIQGIEGRIIFASFASNIFRLQQATEAAVKTGRKIAVFGRSMEKAIVNGIDLGYIKAP
                     KGTFIEPNEIKDYPAGEVLILCTGSQGEPMAALSRIANGTHRQVQLQPGDTVIFSSSP
                     IPGNTTSVNKLINIISEAGVEVIHGKVNNIHTSGHGGQQEQKLMLCLIKPKYFMPVHG
                     EYRMQKVHAGLAVDTGVEKDNIFIMSNGDVLALTADSARIAGHFNAQDIYVDGNRIGE
                     IGAAVLKDRRDLSEDGVVLAVATVDFKSQMILSGPDILSRGFVYMRESGDLIRQSQRI
                     LFNAIRIALKNKDASVQSVNGAIVNAIRPFLYENTEREPIIIPMILTPDEE"
     gene            complement(16145..16378)
                     /locus_tag="VVR18_001272"
     CDS             complement(16145..16378)
                     /locus_tag="VVR18_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002947111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-dependent RNA polymerase auxiliary subunit
                     epsilon family protein"
                     /protein_id="HEU6032796.1"
                     /translation="MIYKVFYQETKERSPRRETTRTLYLDIDASSELEGRITARQLVE
                     ENRPEYNIEYIELLSDKLLDYEKETGAFEITEF"
     gene            16762..16980
                     /locus_tag="VVR18_001273"
                     /pseudo
     CDS             16762..16980
                     /locus_tag="VVR18_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000184674.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(17196..17348)
                     /gene="cibB"
                     /locus_tag="VVR18_001274"
     CDS             complement(17196..17348)
                     /gene="cibB"
                     /locus_tag="VVR18_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibB"
                     /protein_id="HEU6032797.1"
                     /translation="MMKDLNNYREISNKELQEIKGGFGVGVGIALFMAGYTIGKDLRK
                     KFGKSC"
     gene            complement(17350..17535)
                     /gene="cibA"
                     /locus_tag="VVR18_001275"
     CDS             complement(17350..17535)
                     /gene="cibA"
                     /locus_tag="VVR18_001275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000180803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibA"
                     /protein_id="HEU6032798.1"
                     /translation="MTNFDILDNQFLSLSENELSDIDGGLAPLVIFGVAVSWKAIAGG
                     TALIGSGLAAGYFLGGD"
     gene            17713..18396
                     /gene="tsaB"
                     /locus_tag="VVR18_001276"
     CDS             17713..18396
                     /gene="tsaB"
                     /locus_tag="VVR18_001276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HEU6032799.1"
                     /translation="MKVLAFDTSSKALSLAILEDKQILAEMTINIKKNHSITLMPAID
                     FLMASLDWTPKDLDRIVVAEGPGSYTGLRIAVATAKTLVHTLNIELVGMSSLLALVPY
                     QQEGLFVSLMDARRNNVYAGFYENAKPVMPEAHLPFERVIELIKGASQVTFVGEVGPF
                     VEQIQKHLPRTNFKETLPNAANLALWAWDKEADSLHDFVPNYLKRVEAEENWLKNHTE
                     SGESYIKRL"
     gene            18393..18830
                     /gene="rimI"
                     /locus_tag="VVR18_001277"
     CDS             18393..18830
                     /gene="rimI"
                     /locus_tag="VVR18_001277"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HEU6032800.1"
                     /translation="MIEIKRIQQQPALAQDIYAVMAAVYPVSPWTLEQIQADLSQDQT
                     WYALAYDGAEVIGFLAVQETLFEAEVLQIAVKGAYQGQGIASALFAQLPTDKEIFLEV
                     RKSNQRGQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG"
     gene            18820..19830
                     /gene="tsaD"
                     /locus_tag="VVR18_001278"
     CDS             18820..19830
                     /gene="tsaD"
                     /locus_tag="VVR18_001278"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HEU6032801.1"
                     /translation="MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGG
                     VVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFA
                     WAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDELAHQGQDIYDFPRAMIKEDNLEFSFSGLKSA
                     FINLHHNAEQKGESLSTEDLCASFQAAVLDILMAKTKKALEKYPVKTLVVAGGVAANK
                     GLRERLAAEITDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFAGWDLNAKPSLAFDT
                     ME"
     gene            complement(19870..21176)
                     /locus_tag="VVR18_001279"
                     /pseudo
     CDS             complement(19870..21176)
                     /locus_tag="VVR18_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011680908.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(21451..21824)
                     /locus_tag="VVR18_001280"
                     /pseudo
     CDS             complement(21451..21824)
                     /locus_tag="VVR18_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(21931..22224)
                     /locus_tag="VVR18_001281"
                     /pseudo
     CDS             complement(21931..22224)
                     /locus_tag="VVR18_001281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            22467..23147
                     /locus_tag="VVR18_001282"
                     /pseudo
     CDS             22467..23147
                     /locus_tag="VVR18_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200043.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
BASE COUNT         7236 a         3940 c         4906 g         7121 t
ORIGIN      
        1 catatcaact aggtcattag attttattga agatataaat taaaaacgag gttgggaaaa
       61 aactcaattt gaaagtgaga ttgagtaaat ctttctatct atataacgta tatcatcaat
      121 atttttgaac acctgataat atgcattttt cttattttaa agattttttg cctttcttca
      181 tttcttgaat gaattggaga gatgacttta tttaggtgtt tgacattact atagatagga
      241 tttagcagta ctaatatgaa ctcatattat aggtgcagac ttaaattttg gaagcaagct
      301 aaaggatatc ttatctaggt aactaagtgc tataacaaga tatattggtg gagttagtat
      361 ggcaactatt actaatgctc ttaatattgc ggctactgtt gctgaagtct tctcattagg
      421 aggagccatt gcatatggtt tagatatcgt agacggtaaa tttgatggat atttatgggc
      481 gtaaaactat agctatgaaa catttttttg caggaattgg tgaaattcat tttttgttat
      541 ttttattata tctaagcatg tctaccagtc caattattgg actagtgatt ggatatacta
      601 aaataaatct aataaattct attattatag ctcttggtat gatattggca ttaattttgg
      661 tattatcaag agtgtataga aaatattttt atagagacga tgatgactaa agtttttatc
      721 aataatttgg gctccttgtc aactgtagtg ggttgaataa aagctaacgt ctggggaagg
      781 gtttaaagct ttactttatc aaatattgac ttacagagtt gctctattgt attgatgtat
      841 tcttagtaaa taatatggtg ttttgaatga aagatgatca gaaatattta ttagcgggac
      901 tttattcgct tctagttgca atattttatt ttccattgat tgattccaag gggatttttg
      961 taagtatatt gatggcggtt ttacttttat atttaatata cttcattgca acagtcattc
     1021 atattgtgat aattaagttt ataagaaaaa aatcttttaa gtatttggtt ctatatccat
     1081 ttacttatga tgggagctgg agatttcaac ctataaactt actctacttt ccagaaatgg
     1141 tgagagatgt cattccgatt aatttagttc aagaatattg ccaaggacaa ccttacggac
     1201 tgttaaaaaa gatgctgaaa agaattcgat tgtcacgaga gatagcttta ctcctggcta
     1261 ccattatcgt ctattttttt acgcatagaa ttctacctct ttcagtattt acgttcatgt
     1321 tctcttacat attgctattt gtacaatctt atttgggtag caataccgct tggattggaa
     1381 atagaagatt aataatagat gatgaatttg aaaaaatctt gctttcaaaa agttatgtaa
     1441 aagaaatatc atctgcacga tactcagaat acttgacatg tgaatacaaa aaccttacac
     1501 caatcatatt gatagctatt tttgaaaatt tgcttgactc ctacttgctt cagaatcaga
     1561 gtgaggttga cttagatatt ttttataaag ttttaccttt gctttataaa gaaaaatata
     1621 ctatgggatt caattacttt gtaagtttaa attatttact atataaggtt ggatttttgg
     1681 gaatcattta cgataatgaa gcattaagag atttgtcaaa acaatattta aacaaaaata
     1741 tttcggaatt acaagatggt tctttcgagg gcggtataca agatgctgtt gcctctaaac
     1801 aaatagtagt tataaatgaa tttatagctt gtttaaattc cagatgcatg ccatcccaat
     1861 atgatagatt tttttataaa gatagacctt atattttttc cagaaagagt cctattaagg
     1921 ggtgaaaatt tgttacattt ggattaacaa gtgtcctagg gattagaaat aactctagta
     1981 tagctagata tttttgagta actagaaata tcattaggct actcatatga ttgccagaaa
     2041 agatggctga tgaatcttat ttatactgtt gcagtaggcg ttgtctagga taaataagct
     2101 atcttgatgg gggagattgg aataatttta gtagaaacat taaaggatta tgggcaagta
     2161 gcataggatt aggtgatgca atgtgctaag ttggcttggt gttagcagta gtattattta
     2221 acaatggaaa gtagactaaa tgaaaaataa gcgttatttt tttgacacaa ttttaataat
     2281 tttactgctt ataagcacga tattttgtgt cagcccagta tttataaaat tggacatctt
     2341 aggaactccc tctcatgcca tcttaacctt tgtattggcg ataccgttat tctatatttt
     2401 gtctcaatgc ttacatactt tgctattact agtttcctca atcttttgta aattaagacc
     2461 aatttatttt tattttatat ttgtgatcat tataggagct aggaaatact atcgaattct
     2521 ctttcaccaa ctaatgggat ttagtccagg aatagcagtg ttttataagg agagtcaaac
     2581 aactaagaat ctgtttaaat tttactactt cttgtacttt acaacactaa tttcatacta
     2641 ttttttcttt acttttgtgt atgacaaacc gttgcttttg cctcttattt cattttctat
     2701 tatcatagca ttagtacaaa aactttatag aattgagaat caacaattat ttctgttaaa
     2761 atcaaaggta ctaacaatac tggaatctaa gaagaattgt gagtttaatc ttcaggatta
     2821 tcatgaaatt tggaaattgc aatcaaaatc tgagttgcca tgcgtggctt tatcttatat
     2881 cagtttaatc aagccatatc tttcagagag tgtgcgtgaa caaattgatt tattagaagt
     2941 taagcgattt aaaaaaataa ataatccaat atcactttat ggtatgttgg atgttataaa
     3001 attaaatcta tatttacggc attataatga aaaaaataaa tatgaatcaa tgttaaagaa
     3061 aattttagag gtaagaccag actttgtttt aatcgagcag aatattgatg atagtttaaa
     3121 tagctcgcaa ccattatctt tatctttagc catttcagaa atccaacttt tgcttgaagt
     3181 gtatataggg atcaaacatg tttcaattag gagataaaac tagaataata tttgccatta
     3241 taggggcaag ttgcatatta gtcagtatgt atcttattcc acttattaaa actgagaata
     3301 aattttggga aatactttta tttatattag gtgtattgct aattggaatt gcgttactaa
     3361 gtcaaaaaaa ataaattttg aaatagtatt agtgagttcg caatcattta ttgctagtgg
     3421 tttagaactg ttaagtttca aacaataatt gattttaaac cttaggtaac ctataaaaac
     3481 aaataaggta gagaaaggat atcttatcta ggtagctaag tgataaaaac acagtcgtct
     3541 atcacttgtt aggaaactat cctaactatg cttaataaaa aaggagaaaa taaatggaac
     3601 tcgtattacc aaataattat gttgttcttg agcaagaaga gatgatgtat cttgatgggg
     3661 gattttctat tccgagatgg cctgttgcaa cagccattaa tatagctttt aatggtgttt
     3721 taggtggagg agcaatcagt ctagttagaa attatattcg taattatggt ttgcggcgag
     3781 ttacaagcgc aattgctgga gcagctgcaa gatatgttgg ggtacgagtt gcaaatagag
     3841 tggcaggatt tgcactgcct gctattaatg gatttgcagc ttggatgtca attggcgatg
     3901 ctattacaac aatctgggcc aataatgatg taaataggag agacccaaat ttaaacgcct
     3961 tgtggtaact agatatgggt attaaaatgg aaaaaatttt tgttattatt ttttttgtat
     4021 gtctatttat atcatccata acttttttag cctatgattt tgttagcgaa gaaataaaaa
     4081 agttgattat ttggattaat gtcgtttttt tgattttaat catagcaatg atgatttatc
     4141 caaaattaag aaaatgataa ggacactgta aaattatgat acgtaaacta attgttttct
     4201 tactaatgct ccctcttttt gtcttgtggc tagagttgca tgtcctagtg aataacttac
     4261 tattgaatct agaatctccc cttgattttg tgattagtat gagtcttgct ttctgtagtt
     4321 tgattttatc aaaaatagtt ttagacatac tatacgcatt gaaagattta tacaagaaag
     4381 aaggtcttat taagattttt ccctttattt ttataagaag gaaaaaagtg aatgtgagat
     4441 tctcgcccta tttttcattc catcgtaaaa gtttgtcgcc tgatgattta agatctagga
     4501 ttatatggag ttttattctt gaaattgcta ttatcctagt atttatttta aaaattcctt
     4561 ttgcaatcat catgcttact acaatatttt tctggactat aatggatatc aatcatctag
     4621 tttttaataa gacggaattt ctttttaatc aaaacaaatg gcaaaaagaa gattcgtttg
     4681 aaagtgattt gacgaaaacg ttaaaggata aaatacaaaa gtcagagcta agttattctg
     4741 acttaatgtc tctacagctg tatgatgcga tgaaccaatc caccttttta acggatagtg
     4801 aactctttga ggctattctg ggaaaaattg tagattctga gagcactctt ctttgtatag
     4861 gacttgtaga gttgctgcta tatgaaattt ctattagtaa caataacaac tggtccaaca
     4921 aggttgataa aattaggata cacctcatca gaatcaatca attagatttt ttctattata
     4981 caagttggtt aaggcaaaat tttgatttct gtatgaatag agagtatcat aaaatgaaat
     5041 ctcggaaatt attactgagt aataaaaaga tagtttaagt tcgtcctatt tgtaaaacaa
     5101 atgaaacaat ttcaactaag gaggagaaaa caaatggaac ttgtattacc aaataattat
     5161 gttgtgattg atgaagaaga aatgatgtat cttgatgggg gaacttattt aagcaagcgt
     5221 gcttgtcaag gaatttgcgt agctttagct atgagtccag gaacttttat agcattagct
     5281 ggagctgcag ttttaaccaa aaaactaata aactatatta aggttggaag ctttggaggc
     5341 tggcttattg gtgcagcagc aggtgtattg gctacagcag caggaaaaat agcttactgt
     5401 attggatatg gtgctcttaa tagaggttgt gatattagcg ggaaccctta tccttggaat
     5461 ggattcatat ctgtgacagt aagatgaata atgtagataa gattcgaaaa atacacatca
     5521 tcgtgtattg ggtgtatata tttttatcat tcagggcgat tataaatgat acggagtatt
     5581 ttttgcttat ttttttagct tttatctact caatagtatc actacctcta tattctgtga
     5641 aaaataaaat agtatctatc tgtctagcca taaattcgat tctgttaatg agtttcccca
     5701 ttttaatcaa taagtttttc ccagaaagtt ttttgactta taccgtatta ataagtgttt
     5761 ttattacaga gttgataatt tttcatttaa ttgggaaaga ttttgctact aaattgacta
     5821 acgaatataa gaaaattagt cagtttagaa gcaaggtgtc tcaatctcct tggataaaat
     5881 atttagagat ttctagtttt atattaacta tatttccatc tattctttat ggtacagttg
     5941 ataatcgtgt attggctctt atctttttga taaaaatttg tgtagatact acgataaaat
     6001 ttttattcat cagattattt gacacaagta ctttaatgaa gaggaggata ttttttcttt
     6061 tcgcattgga tgttatagct tacttatttt taggatatct tttagtgatt caaaaagcag
     6121 gctatttgtt ttcggtttta cttctttttt ctaatttttc agttccattt atcaaagaaa
     6181 aggaatacga attatttaaa aatagcaagt aatagaaaca taggttaaat cttagaacgg
     6241 cttaaaatca gatatgataa agggaaatag tcttatctag gtaactaagt gctacaaaca
     6301 cagtcgagga tcacttgtta ggattacatt ttaatcatgc ttaataagaa tggagaattc
     6361 ctatggggat tgtattactc tgaagtttcg aataccttag ttctcgtgat tttgagctat
     6421 tctagcttta gaatccttca gaacgtaaaa ttttaagcag tcaaagactt agaatagccc
     6481 gaaaacattt attttataac aattctaagc ttagaattgc tcatatatat gtatttgagc
     6541 tgctcgatag ttaggacagc tttattctga gaaatctgag ctatcaatgc ttcagaatag
     6601 tatttcgcca atggttttta ttgaagaggt gattgtttta tgatagtcta aaataaaact
     6661 gatttaatgg agaatcgtta catgaaacat ttttttgcag gaattggtga gataaaactt
     6721 gttggctact tattgtatat atgtgtagga ctagcccctc tttttcatat atatgtcata
     6781 ggttcggaac tgagttttgt gaaaatagtg ttatctattt tgggaattat atttgtaagt
     6841 atgttaacta ttgctcgaat ttataggatt tttttctata aagaatagtt tggacttgaa
     6901 ctgtatctaa aaacagagat tggtcgatta tcagcctctt tcttgtcgtt gaaaagagtg
     6961 agatatattg acttttgaaa aaaagatgtc ataattgagt tgggataaac ctaaaaataa
     7021 tatagtagat tgaatctgga atagtccgtt atgaccgtta aaatatttct agaaattaat
     7081 ttgactttcc taatcgattt gttcacatct tgtttcaatc tactatactt tctcgttaaa
     7141 ccgttcggca attcatggtg acatggacac atagtagtaa gcacactatg tggcttggca
     7201 gagctaaaaa ctgttccctt gcgataagcc taataagcac aacataggga gttagagaag
     7261 ccgactctaa tcaaacactt tgggcagtag tgagaactgc cccgtgcttt ttattttgag
     7321 aaaatatgga gtttgtcgtt gaaattactt gattgtattt tggattatca agaaagattc
     7381 aatagaaaaa catgtcaagt atcaacgaat tataagtatt tagagacttt caaagtgaat
     7441 ttttgcctga ctgatttaca tcatttattt ggcttacaca aaatcacacg agattttgct
     7501 agtcatacga tatctgttat tcaaactggt gtttttattt tagaagattt tagaaatatc
     7561 ctattgtaca atgatgtaat cgaaaggata tctttatatg agtttatcgg cgatatcttc
     7621 tattctaagc taacaagttg ttgcatcgta gctaaggatt tatctaaaaa tactatgaaa
     7681 ttggacgtca tattttttga ggataaaaat aaaatatccg cagttttagg tttacgaaga
     7741 gacaaaagcg gagtatttaa accagttact ctatatttta caagcgctaa gaaatatgct
     7801 aaagttcgta aaacagatgt gaaagaaatg aaatggctat aaagattgtc cgcaggctta
     7861 agcttgcgtt ttttgttgtt taacgaaatt aaaaaataag ctctctcatt ggaaatgttt
     7921 ttataggaat gaaggaagat gatgctatgt ttaaaaagag aatcgaaaag ggcaaaagta
     7981 gtgtctttat ctttttggag tagaagctta tgatatagaa atttgtaata aaaatgtaat
     8041 ataaaacatt tgacaaatat ttacgggggg agtatactta atataagtat agtctaaaaa
     8101 tgactatcag aaaagaggta aatttagatg aataagaaaa aaatgatttt aacaagtcta
     8161 gccagcgtcg ctatcttagg ggctggtttt gttacgtctc agcctacttt tgtaagagca
     8221 gaagaagctc ctgtagctaa ccagtctaaa gctgagaaag actatgatgc agcgaagaga
     8281 gatgctgaga atgcgaaaaa agctttagag gacgcaaaac gtgcgcagaa aaaatataag
     8341 gatgatcaga agataactga ggagaaagcg gaagaagaaa aaaaagcttc tcaagagcaa
     8401 caaaaagcaa atctggacta tcaacaaaag ttgaggaaat atattaacga aaaagactcc
     8461 aaaaaaagat ctatgcttca gaaagaaatg gaggaagctg agagaaaaga taaggaaaaa
     8521 caagcagaat ttaagaagat tagagaaaag gtgattccta gcgcggaaga gttaacagag
     8581 actagacgaa aagcagaaga ggctgaagca aaagaaccag agcttactaa aaaagtaaaa
     8641 gaagctgagg aaaaagttac tgaagccaaa caaaaattgg atgctgaacg tgctaaagaa
     8701 gttgctcttc aagccaaaat cgctgagttg gaaaatgaag ttcatagact agaaacaaaa
     8761 ctcaaagaga ttgatgaatc tgactcagaa gattatgtta aagaaggtct ccgtgctcct
     8821 cttcaatctg aattggatgc taagcaagct aaactatcaa aacttgaaga gttgagtgat
     8881 aagattgatg agttagacgc tgaaattgca aaacttgaaa aagatgtaga agatttcaaa
     8941 aactcagacg gtgaatattc tgcattatat cttgaagctg cagaaaaaga tttagctgct
     9001 aaaaaagctg aattagaaaa aactgaagct gacctcaaga aagcagttaa tgagccagaa
     9061 aaaccagctc cagctccaga aactccagcc ccagaagcac cagctgaaca accaaaacca
     9121 gcgccggctc ctcaaccagc tcccgcacca aaaccagaga agccagctga acaaccaaaa
     9181 ccagaaaaaa cagatgatca acaagctgaa gaagactatg ctcgtagatc agaagaagaa
     9241 tataaccgct tgactcaaca gcaaccgcca aaagcagaaa aaccagctcc tgcaccacaa
     9301 ccagagcaac cagctcctgc accaaaaaca ggctggaaac aagaaaacgg tatgtggtac
     9361 ttctacaata ctgatggttc aatggcgaca ggatggctcc aaaacaacgg ttcatggtac
     9421 tacctcaaca gcaatggtgc tatggcaaca ggttggctcc aaaacaatgg atcatggtat
     9481 tacctaaatg ctaacggtgc tatggcaaca ggatggctcc aaaacaatgg atcatggtac
     9541 tacctcaaca gcaatggcgc tatggcgaca ggatggctcc aatacaatgg ttcatggtac
     9601 tacctcaacg ctaatggtga tatggcgaca ggatggctcc aaaacaacgg ttcatggtac
     9661 tacctaaacg ctaacggtgc tatggcaaca ggttgggcta aagtcaacag ttcatggtat
     9721 tacctcaacg ctaacggtgc tatggcaaca ggttgggcta aagtcaacag ttcatggtat
     9781 tacctcaacg ctaacggtgc tatggcaaca ggttgggcta aagtcaacgg atcatggtac
     9841 tacctcaacg ctaacggttc aatggcaaca ggttgggtga aagatggaga tacctggtac
     9901 tatcttgaag catcaggtgc tatgaaagca agccaatggt tcaaagtatc agataaatgg
     9961 tactatgtca atggcttagg tgcccttgca gtcaacacaa ctgtagatgg ctatgaagtc
    10021 aatgccaatg gtgaatgggt ttaagccgat taaattaaat catgttaaga acatttgaca
    10081 ttttaatttt gaaacaaaga taaggttcga ttgaatagat ttatgttcgt attctttagg
    10141 tacctatctt atgatttcag gaaatgtcat taaaaaaacg actccttttc tctaacttga
    10201 aaaatagatt agagaaaagg ggttgtttta tttattatag ttatttgaat gaagataaga
    10261 agaaggtata ctcacgtcat tcacatgatc tgtatattga ctataagttt taaaaaacaa
    10321 tttttaagct cttccttgtc ttctctaacc aagcgtgtta taatgaatac tgctcaagcg
    10381 accttcaatc gtgaagcaca cacgaccttc aatcgtgaat aaacgaatag atgggagact
    10441 taccatgagt gataactcta aaacacgtgt tgtcgtgggg atgagtggtg gtgttgattc
    10501 gtcggtgacg gctcttcttc tcaaggagca gggctacgat gtgatcggta tcttcatgaa
    10561 gaactgggat gacacagatg aaaacggcgt ctgtacggcg accgaagatt acaaggatgt
    10621 ggttgcggtg gcagaccaga ttggcattcc ctactactct gtcaattttg aaaaagagta
    10681 ctgggaccgc gtttttgagt atttcctagc ggaataccgt gcgggacgca cgccaaatcc
    10741 ggacgttatg tgcaacaagg aaatcaagtt caaggccttt ttggactatg ccatgacctt
    10801 gggggcagac tatgtagcga ctgggcatta tgctcgagtg gtgcgtgatg aggatggtac
    10861 cgttcacatg cttcgtggcg tggacaatgg caaggatcag acctatttcc tcagccaact
    10921 ttcgcaagaa caacttcaaa aaaccatgtt cccactagga catttggaaa agcctgaagt
    10981 tcgaaaacta gcagaagaag caggcctttc gactgctaag aagaaagact cgacagggat
    11041 ttgctttatc ggagaaaaga actttaaaaa ctttctcagc aactacctgc cagctcagcc
    11101 tggtcgtatg atgactgtgg atggtcgcga tatgggcgag catgcaggtc ttatgtacta
    11161 tacaatcggt cagcgtggcg gactcggtat cggtgggcaa cacggtggtg acaatgcccc
    11221 ttggttcgtt gtcggaaaag atctaagcaa gaatattctc tatgtaggcc aaggtttcta
    11281 ccatgattcg ctcatgtcaa ccagcctaga ggctagccaa gtccacttta ctcgtgatat
    11341 gcccgaggag tttacgctag aatgtacggc taaattccgt taccgtcagc ctgactctaa
    11401 ggtgaccgtc catgtcaaag gagacaaggc agaagttatc tttgcggaac cacaacgcgc
    11461 gattacacca ggacaggcag ttgtctttta cgatggcgaa gagtgtctag gtggtggttt
    11521 gattgacaat gcttaccgcg atggacaagt ttgtcagtac atttagattg acaaattttc
    11581 tcaatttgct acaataataa cagcaataga aatgatggtc aaagctcatg gatgttgcag
    11641 gcttttttgt cctgcacttc tttgtagttt tgactgtttt tgtgtcgttt aagggaaagg
    11701 acaagaatga ctcaacaaga ctttcggaca aaagtagaca atacggtttt tggtgttcgg
    11761 gctacagcct tgattgtcca aaatcacaag cttctagtta ccaaagacaa gggcaagtat
    11821 tacactattg gaggtgcgat tcaagtcaat gaaagcacgg aagacgcggt agtccgtgaa
    11881 gtgaaggaag aactgggtgt caaagctcaa gctgggcagc tagcttttgt ggttgaaaat
    11941 cgttttgaac aagacggcgt ttcctatcac aatatcgagt ttcattatct ggtggatttg
    12001 cttgaagatg ccccgttgac catgcaggaa gatgagaaaa ggcagccctg tgagtggatt
    12061 gacttggata agcttgagga tatccagcta gttccagcct tttaaaaaac ggccctacca
    12121 gattgggaag gccaactaag acacatccat cttgagaaat aggagagaaa tatgacatat
    12181 cattttactg aagaatacga tattattgta attggtgcgg gacacgctgg ggttgaggct
    12241 tccttggccg ctagccgtat gggctgtaag gtcctgcttg cgaccatcaa tattgaaatg
    12301 ctggctttca tgccttgtaa tccctctatc ggtggttctg ccaaggggat tgtcgtgcgt
    12361 gaagtcgatg ccctcggtgg cgagatggcc aagactattg acaagactta catccagatg
    12421 aagatgctca acacagggaa ggggccagct gtccgtgctc ttcgtgcgca ggctgataag
    12481 gaactttact ctaaggaaat gcgcaagaca gttgaaaacc aagaaaatct gacccttcgt
    12541 caaaccatga ttgatgagat tttggtggaa gatggcaagg ttgtcggtgt gcgtacagcc
    12601 acccatcaag aatatgctgc taaggctgtt attgtgacga cagggactgc tctccgtggg
    12661 gaaattatca tcggagacct caagtactca tcaggtccta accacagctt ggcttctatt
    12721 aacctagctg acaatctcaa ggaactgggc ctcgaaatcg gtcgtttcaa gacaggaacc
    12781 cctccacgtg tcaaggcttc ttctatcaat tacgatgtga cagaaatcca accaggagat
    12841 gaagcgccta atcacttctc atacacttca cgtgatgagg attatgtcaa ggaccaagtg
    12901 ccatgctggt tgacctacac caatggtacc agtcatgaga ttatccaaaa caacctccac
    12961 cgtgcgccta tgtttacagg tgtggtcaag ggagtggggc ctcgttactg tccgtcgatt
    13021 gaggacaaga ttgtgcgctt tgcggacaag gaacgccacc aactcttcct tgagccagaa
    13081 gggcgcaata ctgaggaagt ctatgtgcaa ggactttcaa ccagtctgcc tgaggatgtc
    13141 cagcgtgact tggttcattc catcaaaggt ttggaaaatg cagagatgat gcggacaggt
    13201 tatgctattg agtatgatat ggtcttacct catcagttgc gtgcaacttt ggaaaccaag
    13261 aaaatctcag gtctcttcac tgctggtcag acaaatggaa cgtcaggtta cgaagaggca
    13321 gcaggccaag ggattatcgc gggtatcaat gcggctctga aaatccaagg caagcctgag
    13381 ttgattttga agcgcagtga tggttatata ggggtgatga ttgatgactt ggtgaccaag
    13441 ggaaccattg aaccctaccg tctcttgact agtcgtgctg aataccgtct cattcttcgt
    13501 catgacaatg ctgatatgcg cttgactgag atgggacgcg agattggcct tgtggatgat
    13561 gaacgctggg ctcgttttga aatcaagaaa aatcaatttg aaaatgagat gaagcgccta
    13621 gatagcatca aactcaagcc agtcaaggaa accaatgcta aggttgagga aatgggcttc
    13681 aagccgttga cagatgcggt gacagccaag gaattccttc gccgtccaga agtttcttac
    13741 caagatgtgg tggccttcat cggaccagct gctgaggact tggatgacaa gattatcgaa
    13801 ttgattgaaa cagaaatcaa gtatgaaggc tatatttcca aagccatgga ccaagttgcc
    13861 aagatgaaac gcatggaaga aaaacgcatt ccagccaata ttgactggga tgacattgac
    13921 tctatcgcaa ccgaagctcg tcagaagttc aaactcatca atccagaaac tatcggccaa
    13981 gccagccgta tttcgggagt aaacccagca gatatttcta ttttgatggt gtatctggaa
    14041 ggtaaaaatc gtagtatttc taaaactctt caaaaatcaa aatgatacgt cgtcggctgc
    14101 ttacgaatga gttcaaagct tggctttgat tcatctccaa cctcccatag ttccccgaac
    14161 tatgggagct aactcaagtt atgcattttc ctagccttct ggtctgattt tcattgagtt
    14221 ttaatctcaa aagaaagcat agagaaaaac agctccgaag acggggctgt tttgttgact
    14281 tgtactcaat gaaaatcaaa gagcaaacta ggaagctagc cgtaggttgc tcaaagcact
    14341 gatttgaggt tgtagataga actgacgaag tcagctcaaa acacagtttt gaggttgtgg
    14401 atagaattga cgaagtcagt aacatatata cggcaaggcg aagctgacgt ggtttgaaga
    14461 gtattattct tcatctggtg tgaggatcat cgggatgatg atcggttcac gttcggtatt
    14521 ttcatagagg aaggggcgaa tagcgttgac aatggcacca ttgacagatt gcacgctagc
    14581 atccttattt ttcagtgcga tacgaatggc attgaagagg atacgctggc tttggcgaat
    14641 caagtcgcca gactctctca tgtagacaaa gcctcggctg aggatgtctg gaccagatag
    14701 aatcatctgc gatttgaagt caacagttgc aactgccaga acgacaccgt cttcagatag
    14761 atcgcgacga tctttgagga cagctgcgcc aatttcaccg atacgatttc catcgacata
    14821 gatatcttgg gcgttgaaat gacctgcgat acgagctgag tcagcagtaa gggcaagcac
    14881 atcgccattg ctcatgataa agatattgtc cttctcaaca ccagtatcca ctgctagtcc
    14941 agcgtggact ttttgcatgc ggtattcacc gtggacaggc atgaagtatt ttggcttaat
    15001 caagcagagc atgagttttt gctcttgctg accaccgtgt ccagatgtat ggatattgtt
    15061 cactttaccg tggataactt cgacaccagc ttcagaaatg atgttaatca gcttgttgac
    15121 gctagtagtg tttccaggga tgggactaga agagaagata acggtatcac ctggttgtaa
    15181 ttgtacttga cggtgggttc cgttggcgat acgagagagg gctgccatag gctcaccctg
    15241 actacctgta cagaggataa gaacttctcc tgcaggataa tctttgattt catttggctc
    15301 gataaaggtt cccttaggag ctttgatgta gccaagatcg attccgttga caatggcctt
    15361 ttccatagaa cgaccaaaga ccgcaatctt gcgtccagtc ttaacagcag cttctgttgc
    15421 ctgctggaga cggaagatat ttgaggcaaa ggatgcaaag atgatacgtc cttcaatacc
    15481 ttggataatc ttcataatgg actgaccaac gactttttca gagttggtaa aggttggtac
    15541 ttccgcattt gtcgagtcag acaggagaca gagcacgcct tcttcaccaa gcgcagccat
    15601 acgatgcaag tccgcaggtt ctccaactgg agtaaagtcg aacttaaagt cacccgtaca
    15661 gacgattttc ccttgaggag tatgaatgac aatccccaaa ggctctggaa tagagtgagt
    15721 cgttctaaag aaagttgcct tgagattttt aaaggtcaac tcggtgttgt ggttgatttc
    15781 gtaaagtttg gcgttgcgca agaggccgtg ttcttcgagt ttcccacgga tcaaagccaa
    15841 ggcaagcggt ccagcgtaga tagggacatt tgcttgcttg agtaggaacg gaatcccacc
    15901 aatgtggtcc tcgtgtccgt gtgtgattaa aacagccttg acgcggtcga tattgtccac
    15961 gatgtaagag tagtcaggaa tgacatagtc gataccaagc aagtcatctt ctgggaattt
    16021 aatcccagca tcgacgatga taatctcgtc ttggtattca attccgtaag tgtttttccc
    16081 gatttctcct agaccaccga tggcaaaaac gccgacttct tcaggtttaa gagtgtaggc
    16141 catattagaa ctccgtaatt tcgaaggcgc cagtttcttt ttcgtaatcg agcaatttgt
    16201 cagacaagag ttcgatatac tcgatattgt actctgggcg attttcttcg acaagttggc
    16261 gagcagtgat acggccctca agttctgagc tggcatcgat gtctaggtaa agcgtgcgtg
    16321 ttgtttcacg gcgtgggcta cgttcttttg tttcttgata aaaaactttg taaatcatat
    16381 agttcctttc tatttacagg tcagcttatt ccaaactttt agcagatatt tgcttgattt
    16441 cattccattt tgtgtctaga ttgaccttga ttcgttacaa ttatttcaat tataccacaa
    16501 aatgaaaaat tagtaaaaga cggaaacgag aaagttaggg gacgatttct ttggtaagcg
    16561 tttgcaaaaa taaagaaaat gtattatgtt gataacggaa gtgaaattta ttgcttgtca
    16621 taattccata tagattttaa gtcaaggagg ttgccctatg tataacttat ttgcttttgc
    16681 tatcggagct cgcttggtag cttttattgt ttttgttgct tgcgtttatg cggggaatct
    16741 tctatttgcc aaactggaac gatgacaaac caagttcttg tggaaaatga cctttgtgac
    16801 tctctactcg ctttttctcc tcctcatgac ctatgtcgtt tggtttgtat tttactttgg
    16861 attaaatgct tagatgccct gcttatgctg gggttttttg tttggggatg tagagatagt
    16921 agatttacga cacgaaaatt ctaccccatc tatcaagatg aggtggtttt tgtatttttt
    16981 agaaatgaca tgataatggt attttcagag cttattagtt ttatggtaat cattcttctg
    17041 ctcaaaaata gagttgaagc ataaaaataa aacaatacaa acagataaat cgaatggtaa
    17101 agggatagta gtaatgttca aatcattgag aatgctgagc aaactgtaag agatgaagac
    17161 aataaaattt atccttctaa aaatgtgttt cttatctagc atgatttacc aaacttttta
    17221 cgaaggtctt ttccaatggt ataacctgcc ataaataaag cgataccaac acctacacca
    17281 aagccaccct tgatttcttg caattcctta ttagaaattt cacgatagtt gttcaaatct
    17341 ttcatcatat taatctcctc ctaaaaaata accagctgcc aaaccagaac ctataagtgc
    17401 tgttccacct gcaatagcct tccaagatac tgctactcca aagataacca agggagcgag
    17461 accgccatca atatctgata attcattttc agataaggat aaaaattgat tgtcaagaat
    17521 gtcaaaattt gtcattgaat tttcctcctt ttttcttgtt cacttttata ttcggaaaag
    17581 aaaaggaaaa gtgagcattt ttttaaatta tttttagtta agtgagggca ctcttgtctg
    17641 ggggcaaaga aaattcccat gtgccagctt ttgtagtata atagtaagca gacaaaaaga
    17701 taggaatgtg ttatgaaagt attagctttt gatacgtcca gcaaggctct ttctctcgct
    17761 attttagagg acaagcagat tcttgccgag atgacgatta atattaagaa aaatcacagt
    17821 attaccctca tgcctgccat cgattttttg atggcaagtt tggactggac acccaaggat
    17881 ttggaccgaa tcgtggtggc tgaagggcca ggtagctaca caggcttgcg aattgcggta
    17941 gccactgcca agactttggt tcatactctg aacatcgagt tagttggtat gtctagcctc
    18001 ttggctctgg taccctacca acaagaaggc ttgttcgtct ctttgatgga tgcgcgtcgc
    18061 aacaatgttt atgcaggatt ttatgaaaat gctaaacccg tcatgccaga agctcactta
    18121 ccctttgagc gagtgattga gttaatcaag ggtgctagtc aggttacctt tgtcggagaa
    18181 gttggcccct ttgttgagca gattcaaaaa cacttgccaa ggactaattt caaagaaacc
    18241 ttgcccaatg cagctaatct agctctatgg gcctgggaca aggaagcaga ctccttgcat
    18301 gattttgtgc cgaactacct caagcgtgtc gaagctgagg aaaactggct caagaatcac
    18361 accgagtctg gcgagtctta cattaaacgc ttatgataga aatcaaacga atccaacagc
    18421 aacctgcctt ggctcaagat atctacgctg tcatggcagc tgtttaccca gtcagtcctt
    18481 ggacactaga acaaatccaa gcagatctgt cccaagacca gacttggtat gcattggctt
    18541 atgatggggc agaagtgatt ggatttctag ctgttcagga gactctcttt gaagcagaag
    18601 tcctgcaaat cgctgtcaaa ggagcctatc agggtcaggg aattgcgtca gccttgtttg
    18661 ctcaattgcc gacagataag gagattttcc tcgaagtcag aaagtcaaat caacgagggc
    18721 aagcatttta caagaaagaa aagatggcag ttatcgctga gcgaaaggcc tactaccatg
    18781 acccagtcga ggacgccatt atcatgaaga gagaaataga tgaaggatag atatatttta
    18841 gcatttgaga catcctgtga tgagaccagt gtcgccgtct tgaaaaacga cgatgagctc
    18901 ttgtccaatg tcattgctag tcaaattgag agtcacaaac gttttggtgg cgtagtgccc
    18961 gaagtagcca gtcgtcacca tgtcgaggtc attacagcct gtatcgagga ggcattggca
    19021 gaagcaggga ttaccgaaga ggacgtgaca gctgttgcgg ttacctacgg accaggcttg
    19081 gtcggagcct tgctagttgg tttgtcagct gccaaggcct ttgcttgggc tcacggactt
    19141 ccactgattc ctgttaatca catggctggg cacctcatgg cagctcagag tgtggagcct
    19201 ttggagtttc ccttgctagc ccttttagtc agtggtgggc acacagagtt ggtctatgtt
    19261 tctgaggctg gcgattacaa gattgttggg gagacacgag acgatgcagt tggggaggct
    19321 tatgacaagg tcggtcgtgt catgggcttg acctatcctg caggtcgtga gattgacgag
    19381 ctggctcatc aggggcagga tatttatgat ttcccccgtg ccatgattaa ggaagataat
    19441 ctggagttct ccttctcagg tttgaaatct gcctttatca atcttcatca caatgccgag
    19501 caaaagggag aaagcctgtc tacagaagat ttgtgtgctt ccttccaagc agctgtcttg
    19561 gatattctca tggctaaaac caagaaggct ttggagaaat atcctgttaa aaccctagtt
    19621 gtggcaggtg gtgtggcagc caataaaggt ctcagagaac gcctagcagc cgaaatcaca
    19681 gatgtcaagg ttatcatccc ccctctgcga ctctgcggag acaatgcagg tatgattgcc
    19741 tatgccagcg tcagcgagtg gaacaaagaa aacttcgcag gctgggacct caatgccaaa
    19801 ccaagtcttg cctttgatac catggaataa ggagtggctc tttgtcaagt gtagtgggta
    19861 ggcgaaaagc tacaatctgg agagtacgaa attcgtactc tcttttttga tgttcaaagt
    19921 catcaaaatc cgttttttaa aattgttaaa gttccggaaa ccaaaggctt tgcgcttgat
    19981 aaccttaatc aaattattgg tcgcttcaag tttagcgttg gaataaggca gcttaagtgc
    20041 gttgataatc ttatctctat cccttaaaaa agtccaaaag accgtttgaa aaagcggatg
    20101 aaccgttggc agttcttgct caatcaatcc aaagaaatgg tcggcattct tctcttgaaa
    20161 atgaaagagc aggagttgat agagttcgta gtgaacctgt aatccctcag agtaagaaag
    20221 cagcttatct cgtacttccc gatgggttaa gtgcattcga aacgtgggct gatagaatcg
    20281 tttctgacag agcttgaagc tatcctggtg tagtaaatca gtccagtgga ctgatttagc
    20341 ccgagcctag aaacgaaaaa gcgagggttc caaaagcgct tgagcgcccg atactccaag
    20401 gattttcggt caaattggtt catgatttgg attcgtactc ggttcatagc tcggctcaga
    20461 tgttggacaa tgtggaagcg gtcaagaaca atcttcgcct ttggaaagag ttgcttagcg
    20521 agccgataat aagggctgta catgtccatg gtgatgacct cgaccagctc ccgaacctct
    20581 ctctgatagc gttggaaatg gtttcgaatc accgcatgag ttcgcccgtc taaaattgcg
    20641 aggatggatt tggactcaaa atcttgggca atgaagctca ttttgctctt tttgaagcta
    20701 tactcatccc aactcataac ttttggcaac ttggtccaat cggtttcaaa cttaaattcc
    20761 ctcagttttc ggatgacggt ggaagttgag accgccaatc tgtgggcaat ctcagtcata
    20821 gactgctttt caaggaggag ctgagcgatt ttttgtctca ccatgttgga aatctggcaa
    20881 tttttcttga caatggatgt ttgagaaacg accaccttaa ggcaattctt gcactgaaag
    20941 cggcgctttt tgagatgcag taccgtgggt aaaccctgac agtcgagaag cggaatttta
    21001 gaggctttct ggaagtcgta tttgatcatc ttcccttgac aatgaggaca aggaggagcg
    21061 ggggaatcca actttgcctg aacgactaga tgggtttggt atttcagaac agacaagatt
    21121 ttgatatttt tgtcttccaa tccgagcaaa tctgtggtat tcttaagttg ttccatatgg
    21181 accctttcta atgagttggt tagacgcttt tcattatagg tcatatgggg ctttttttct
    21241 acaagaaacg accctataat tcctggggtg ggattaccca ctacagaaat tatagagccc
    21301 aaacattcca aagtcttgtc tgactctgga atgttttctg ttcacagttg ttttgtaact
    21361 gcctaataag taaccgcgct ataacgaggt atctaccgag attgtcaatt ctccagtata
    21421 ctgttataaa aaacaaaact ggaggatttt ttatgtcccc ccatcgtccc atcgactgtt
    21481 ccgtagctgc ccaataacgg agtatagtcg gctgaaacaa gaataggaca aaagtgcctc
    21541 aagaaaagca tcgtaatttg acaatattat tctgagatgt ttttgatgta agcccatatt
    21601 ttctcaatgg gattatactc gggtgaatag gtaggaagtg gtaacagtct atgccctgct
    21661 ccttacacat gttcattctg tgaaaccttg cattgtccat aatgataagg gatggtgtat
    21721 ctaatgataa gggatggtgt atctaaagta ggtagtaaga atttttggaa gcaagcttcg
    21781 aaaaagtcac tcgtcatcgt atctttatag gtcatcggag ccatagtata ttgaaacaaa
    21841 aaagggcatt agtacttcta taacagtatc gcaatctctg gtgtgcgttg tctcgatctt
    21901 aattcaaata attatatctt cttccagaga gactaactgc ctgctcaagg ctcgatcata
    21961 ttcgagataa aaataggtct taacccctgt ctcataaata taaataggag tcaggtagct
    22021 taagtgattc aattctttaa ggaaccgatt tactttttct gggtcttgtt cgcagtaggt
    22081 acagctcttt tttagactat atcccatagc ctttagagcg taatgaatag ttgttggagg
    22141 acagttgaat tcagcagcta tttcagtcaa ataagcatcg ggatgagttt caatatagat
    22201 ctttaattta tctctatcaa ctttttcaat taatagtgga agttttctta aagttagtgt
    22261 attgaaacgt ttttatacag tgctaaaatt tgaagtgtag tgcagatata tttgtaatag
    22321 tattatagca attctttgaa gaaggtcgag acaagagaaa ataggtatct ttgagatata
    22381 agcatgattt actataaaat tattgagtta ttcataaaaa tttctctatc aaatatcata
    22441 atgcgtcgtt taaggagatg gttacaatgc aatatagttg tggaaaaata aatattaata
    22501 tccctgatgg atatggagac attaaggata tagtgttttc ggctcatatt atagttaggt
    22561 ataataatgg acattgtgga ggtatagatc cgcatataat tggactttgt aaaaagcaga
    22621 tcagaaggat gtctctatat cctattttga taatcgtatc tagagattca aaggttattg
    22681 atgattataa aaatttagat attgcctatg ttgattgtac tcaatgttca aataattttg
    22741 aaactgcctt acacgttaaa aatattttaa aattattaaa aatccaactt atacactgtc
    22801 atggctactc aactaattat tttttatata tgttaaaaaa acttgacaag aatggatttg
    22861 gaaaggttaa gacagtgata acatgccatg gatgggttga atataactta aaaaagaaat
    22921 tcttgactta ttttgatttt tggacatatt ctatgggaga tgcttttatt tgtgtatctg
    22981 aaactatgaa aaaaagattg gagagtataa taaaaaataa gaagatagtt gcaataaata
    23041 acggaattaa tgtatcaaat agcgatttag atgtagtagg tgttcaagac tttaaaaaag
    23101 aattttgtat tccaaataac aaaaaaatca tttgttatgt tggaaggcaa gagaagaaaa
    23161 aatttttaac gaatttcttt ttttgaaata catgttatta tat
//
LOCUS       DAVHSO010000033        21652 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.033, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000033 DAVHSO010000000
VERSION     DAVHSO010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21652)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21652)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21652
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.033"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(6..524)
                     /locus_tag="VVR18_001283"
     CDS             complement(6..524)
                     /locus_tag="VVR18_001283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ClbS/DfsB family four-helix bundle protein"
                     /protein_id="HEU6032802.1"
                     /translation="MRTYENKEELKAEIEKTFEKYILEFDNIPENLKDKRADEVDRTP
                     AENLAYQVGWTNLVLKWEEDERKGLQVKTPSDKFKWNQLGELYQWFTDTYAHLSLQEL
                     KAKLNENIHSISAMIDSLSEEELFEPHMRKWADEATKTATWEVYKFIHVNTVAPFGTF
                     RTKIRKWKKIVL"
     gene            complement(751..1620)
                     /gene="rsmI"
                     /locus_tag="VVR18_001284"
     CDS             complement(751..1620)
                     /gene="rsmI"
                     /locus_tag="VVR18_001284"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HEU6032803.1"
                     /translation="MQIQKSFKGQSPYGKLYLVATPIGNLDDMTFRAIQTLKEVDWIA
                     AEDTRNTGLLLKHFDISTKQISFHEHNAKEKIPDLIGFLKAGQSIAQVSDAGLPSISD
                     PGHDLVKAAIEEEIAVVTVPGASAGISALIASGLAPQPHIFYGFLPRKSGQQKQFFDS
                     KKDYPETQIFYESPHRVADTLENMLEVYGDRSVVLVRELTKIYEEYQRGTISELLESI
                     AETSLKGECLLIVEGASQDVEEKDEEDLFLEIQARIQQGMKKNQAIKEVAKIYQWNKS
                     QLYAAYHDWEEKQ"
     gene            complement(1623..1940)
                     /gene="yabA"
                     /locus_tag="VVR18_001285"
     CDS             complement(1623..1940)
                     /gene="yabA"
                     /locus_tag="VVR18_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication initiation control protein YabA"
                     /protein_id="HEU6032804.1"
                     /translation="MDKKELFDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRLE
                     NSKLRERLGEVEADAPVKAKHVRESVRRIYRDGFHVCNDFYGQRREQDEECMFCDELL
                     YRE"
     gene            complement(1980..2870)
                     /locus_tag="VVR18_001286"
     CDS             complement(1980..2870)
                     /locus_tag="VVR18_001286"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HEU6032805.1"
                     /translation="MKQDQLKAWQPAQFDRFVRILEQDQLNHAYLFSGFFGSLEIAQF
                     LAKSLFCTDKVGVLPCEKCRSCKLIEQEEFPDVTLIKPVNQVIKTERIRELVGQFSQA
                     GIESQQQVFIIEQADKMHPNAANSLLKVIEEPQSEVYIFFLTSDEEKMLPTIRSRTQI
                     FHFKKQEEKLILLLEQMGLVKKKATLLAKFSQSRAEAEKLANQASFWTLVDESERLLT
                     WLVAKKKESYLQVAKLANLADDKEKQDQVLRILEVLCGQDLLQVRVRVILQDLLEARK
                     MWQANVSFQNAMEYLVLKEI"
     gene            complement(2867..3505)
                     /locus_tag="VVR18_001287"
     CDS             complement(2867..3505)
                     /locus_tag="VVR18_001287"
                     /EC_number="2.7.4.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTMP kinase"
                     /protein_id="HEU6032806.1"
                     /translation="MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGV
                     LIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSS
                     VAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDL
                     EGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK"
     gene            complement(3725..4522)
                     /gene="proC"
                     /locus_tag="VVR18_001288"
     CDS             complement(3725..4522)
                     /gene="proC"
                     /locus_tag="VVR18_001288"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HEU6032807.1"
                     /translation="MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIAD
                     FGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKL
                     ASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
                     LINAATGLAGCGPAFVYLFIEALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQH
                     PGVLKDQVCSPGGSTIAGVASLEAHAFRGTVMEAVHQAYKRTQELGK"
     gene            complement(4526..5788)
                     /locus_tag="VVR18_001289"
     CDS             complement(4526..5788)
                     /locus_tag="VVR18_001289"
                     /EC_number="1.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-5-semialdehyde dehydrogenase"
                     /protein_id="HEU6032808.1"
                     /translation="MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEI
                     LAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLEN
                     GLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
                     KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPV
                     IETGTGIVHVYVDKDADEDKALSIINNAKTSRPSVCNAMEILLVHENKAASILPRLDQ
                     MLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVA
                     HIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQ
                     KLHARGPMGLKELTSYKYVVAGDGQIRE"
     gene            complement(5798..6928)
                     /locus_tag="VVR18_001290"
     CDS             complement(5798..6928)
                     /locus_tag="VVR18_001290"
                     /EC_number="2.7.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004240022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 5-kinase"
                     /protein_id="HEU6032809.1"
                     /translation="MNNRSETMKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAML
                     HEAGHELILVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQI
                     VSAQILLTQDDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDELKVGDNDTLSA
                     QVAAMVQADLLVFLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTG
                     GMLTKIKAATIATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLA
                     FYAQSQGSIWVDKGAAEALSQHGKSLLLSGIVEAEGAFSYGDIVTVFDKESGKSLGKG
                     RVQFGASALEDMLRSQKAKGVLIYRDDWISITPEIQLLFTEF"
     gene            complement(7008..8891)
                     /gene="cbpE"
                     /locus_tag="VVR18_001291"
                     /gene_synonym="pce"
     CDS             complement(7008..8891)
                     /gene="cbpE"
                     /locus_tag="VVR18_001291"
                     /gene_synonym="pce"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine esterase CbpE"
                     /protein_id="HEU6032810.1"
                     /translation="MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSD
                     AIILESNGHFAMVDTGEDYDFPDGSDSRYPWREGIETSYKHVLTDRVFRHLKELGVQK
                     LDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGYDKVLQT
                     AAEKGVSVIQNITQGDAHFQFGDMDIELYNYENETDSSGELKKIWDDNSNSLISVVKV
                     NGKKIYLGGDLDNVHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQ
                     TSDSLPWKNGVDSEYVNWLKERGIERINAASKDYDATVFDIRKDGFVNISTSYKPIPS
                     FQAGWHKSSYGNWWYQAPDSTGEYAVGWNEIKGEWYYFNQTGILLQNQWKKWNNHWFY
                     LTDSGVAAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYKGQW
                     YYFAPSGEMKTGWVKDKEAWYYMDSTGIMKTGEIEVAGHHYYLEESGAMKQGWLKKAN
                     DWYFYKTDGSRAIGWIKEKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVPIEKS
                     ATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNSSTSQDLTSSTSQSSETSVNKSE
                     SEQ"
     gene            complement(8894..9781)
                     /locus_tag="VVR18_001292"
     CDS             complement(8894..9781)
                     /locus_tag="VVR18_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEU6032811.1"
                     /translation="MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKK
                     AKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTS
                     GTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLALAQELKDKKS
                     LRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLV
                     ELQLETGRTHQIRVHMAYIGHPVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTL
                     EFKADIPEIFKETLERLRK"
     gene            complement(9771..10232)
                     /locus_tag="VVR18_001293"
     CDS             complement(9771..10232)
                     /locus_tag="VVR18_001293"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HEU6032812.1"
                     /translation="MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSL
                     TYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLG
                     NFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAILKEEINGN"
     gene            complement(10229..11137)
                     /locus_tag="VVR18_001294"
     CDS             complement(10229..11137)
                     /locus_tag="VVR18_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEU6032813.1"
                     /translation="MNIQQLRYVVAIANSGTFREAAEKMYVSQPSLSISVRDLEKELG
                     FKIFRRTSSGTFLTRRGMEFYEKAQELVKGFDIFQNQYANPEEEKDEFSVASQHYDFL
                     PPTITAFSERYPDYKNFRIFESTTVQILDEVAQGHSEIGIIYLNNQNKKGIMQRVEKL
                     GLEVIELIPFHTHIYLCEGHPLAQKEELVMEDLADLPTVRFTQEKDEYLYYSENFVDT
                     SASSQMFNVTDRATLNGILERTDAYATGSGFLDSDSVNGITVIRLKDNLDNRMVYVKR
                     EEVELSQAGTLFVEVMQEYFDQKRKS"
     gene            11130..11327
                     /locus_tag="VVR18_001295"
     CDS             11130..11327
                     /locus_tag="VVR18_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6032814.1"
                     /translation="MFIFYPQLLYLFIIPYFRSFPKRKKEHPILLNYLHYLPFSRQSY
                     FQNQFKKISGYTPLQYRKEKR"
     gene            complement(11379..12050)
                     /locus_tag="VVR18_001296"
     CDS             complement(11379..12050)
                     /locus_tag="VVR18_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6032815.1"
                     /translation="MKKRAIQILLALSLIFYKSTWFWRVFNHLAKPYLPASREFFQIL
                     LLMESGVLFLAVIYLLVFAGKKIFHFKWQLRYFIYLLLGYIISYMSDFLFSYFISLSS
                     NQISLNETVEMMGRQEFPYFLLIVCFIAPIAEELIYRGVLMTTFFKNSPWYGDVLLSA
                     IIFGYIHINFALTPLAFFIYASGGLILALLYRMTKNLYYPILVHILINITAFWDVWLL
                     LFSGS"
     gene            complement(12104..12325)
                     /locus_tag="VVR18_001297"
     CDS             complement(12104..12325)
                     /locus_tag="VVR18_001297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000602450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0924 family bacteriocin-like peptide"
                     /protein_id="HEU6032816.1"
                     /translation="MILMTKNINLTNEELELIQGGADSYGKNPNGRYDWEIEPVLTLP
                     VHGFCPRGTYDLGYIGGGNHLCKGSAARF"
     gene            12597..13406
                     /locus_tag="VVR18_001298"
     CDS             12597..13406
                     /locus_tag="VVR18_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU6032817.1"
                     /translation="MIKLLALDMDGTLLNEAKEIPQAHITAIHKAIEKGVKLVLCTGR
                     PLFGVLPYYKKLELDLQNEYIIVNNGCSTHQTSDWGLVDWQELSPADIEYLYDLAEKS
                     DVQLTLFDESHYFVLGGKPNQVIENDAKLVFSDLTEISLEEATSGKFRMFQGMFLGTK
                     EQTDDFEQRFAEELCQRFSGVRSQPVIYEAMPLGTTKATALSRLAEILKIDSSEIMAM
                     GDANNDIEMLQFAGLGIAMGNASDYVKSLADAVTSSNEEDGVARAIEKYIL"
     gene            complement(13587..14462)
                     /gene="aguB"
                     /locus_tag="VVR18_001299"
     CDS             complement(13587..14462)
                     /gene="aguB"
                     /locus_tag="VVR18_001299"
                     /EC_number="3.5.1.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-carbamoylputrescine amidase"
                     /protein_id="HEU6032818.1"
                     /translation="MRNVRVATIQMQCAKDVATNIQTAERLVRQAAEQGAQIILLPEL
                     FEHPYFCQERQYDYYQYAQSVAENTAIQHFKVIAKELQVVLPISFYEKDGNVLYNSIA
                     VIDADGEVLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVWNTRYAKIGIGICWDQWFPE
                     TARCLALNGAELLFYPTAIGSEPILDTDSCGHWQRTMQGHAAANIVPVIAANRYGLEE
                     VTPSEENGGQSSSLDFYGSSFMTDETGAILERAERQEEAVLLATYDLDKGASERLNWG
                     LFRDRRPEMYRQITD"
     gene            complement(14472..15557)
                     /gene="aguA"
                     /locus_tag="VVR18_001300"
     CDS             complement(14472..15557)
                     /gene="aguA"
                     /locus_tag="VVR18_001300"
                     /EC_number="3.5.3.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatine deiminase"
                     /protein_id="HEU6032819.1"
                     /translation="MMDSPKKLGYHMPAEYEPHHGTLMIWPTRPGSWPFQGKAAKRAF
                     TQIIETIAEGERVYLLVEQAYLSEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKG
                     KKLAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEALERPVYDAKPFVLEGGAIHSDG
                     QGTILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVA
                     AFVGPAELVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTE
                     EDLPGYIYEEGEEKRYAGERLAASYVNFYIANKAVLVPQFEDVNDQVALDILSKCFPD
                     RKVVGIPARDILLGGGNIHCITQQIPE"
     gene            complement(15554..16681)
                     /gene="nspC"
                     /locus_tag="VVR18_001301"
     CDS             complement(15554..16681)
                     /gene="nspC"
                     /locus_tag="VVR18_001301"
                     /EC_number="4.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxynorspermidine decarboxylase"
                     /protein_id="HEU6032820.1"
                     /translation="MKLEQVPTPAYVIDLAKLEANCRILQYVQEEVGCKVLLAQKAYS
                     LYKTYPLISQYLSGTTASGLYEAKLAREEFPGEVHVFAPAFKDADLEELLGITDHIVF
                     NSERQLRKHGARCREAGVSVGLRLNPQCSTQGDHALYDPCAPGSRFGVTIDKIPSDLL
                     DLVDGLHFHTLCEQGADDLQTTLKAVEEQFGPYLHEVKWLNMGGGHHITREGYDVDLL
                     ISEIKRIRKTYNLEIYIEPGEAIALNAGYLATEVLDIVENGMEILVLDASATCHMPDV
                     LEMPYRPPLRNGFEAQEKAHTYRLSSNTCLTGDVIGDYSFENPVQIGDRLYFQDMAIY
                     SFVKNNTFNGIGLPSLYLMDEQGDCSLLKAFGYQDFKGRLS"
     gene            complement(16681..17940)
                     /locus_tag="VVR18_001302"
     CDS             complement(16681..17940)
                     /locus_tag="VVR18_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000088792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="saccharopine dehydrogenase family protein"
                     /protein_id="HEU6032821.1"
                     /translation="MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLK
                     AKLEGKTSTKIETAALDADKVEEVIALIESYKPEAVLNVALPYQDLTIMDACLATGVH
                     YIDTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSG
                     FDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYW
                     EDGKWVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSY
                     LTHMKCLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGV
                     KDGVKKTIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEE
                     LDPDPFMEALNEYGLPWVVVENPQMVD"
     gene            complement(17937..18797)
                     /gene="speE"
                     /locus_tag="VVR18_001303"
     CDS             complement(17937..18797)
                     /gene="speE"
                     /locus_tag="VVR18_001303"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HEU6032822.1"
                     /translation="MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKI
                     LILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQI
                     DIVEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEDDYDIIINDATDPF
                     GHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQSFPISRVY
                     QAHIPTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGSFMLPKYVE
                     DILEEEEGKK"
     gene            19177..19767
                     /locus_tag="VVR18_001304"
     CDS             19177..19767
                     /locus_tag="VVR18_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6032823.1"
                     /translation="MSLRQLNQDCLIALEDTGHYAFNLLNFLHEQGYKVYTYNPLLIK
                     KFAKSLLLRKTKTDKKDAHGIALKLLSDPNREQFQHDNRQVELKILARHIHRLKKKQS
                     DWKVQYTRCLDIIFPELDKIVGKHSEYTYQLLTCYPNPQKRIEAGFDKLIEIKRLTAS
                     NSRAFCRALKSSPNHQIEIRNSLDKTIDFSYSLSFS"
     gene            complement(19733..21208)
                     /locus_tag="VVR18_001305"
     CDS             complement(19733..21208)
                     /locus_tag="VVR18_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000661022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HEU6032824.1"
                     /translation="MKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELL
                     GEKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGSSHAFLMIGGTTSSVQTMILA
                     TCKAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDH
                     PDAKAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMDAG
                     ADMAAVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRN
                     LALRGKESFEEVIELSEYARHEINAIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIG
                     LTGIEVYDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGK
                     DLIAGEYIQPELVLSPQEAFYSERKSLTLDESVGQVCGEFVMCYPPGIPILAPGERIT
                     REIVDYIQFAKERGCSLQGTEDPEVNHINVIKRKTNYKKSQ"
BASE COUNT         6294 a         5004 c         3904 g         6450 t
ORIGIN      
        1 ataatttata atactatctt cttccatttt ctgattttag ttctgaaagt tccaaaaggt
       61 gcaaccgtat ttacatgaat aaacttatac acttcccaag tcgctgtttt agtcgcttca
      121 tcagcccact ttctcatatg cggttcaaat aattcttcct cactcaacga atcaatcatt
      181 gcagagatag aatgaatatt ttcatttaat tttgctttca actcttgcag agataaatga
      241 gcgtaggtat ctgtgaacca ctgatataat tcaccaagtt gattccattt aaatttatcc
      301 gatggtgttt ttacttgaag cccctttctt tcatcttctt cccatttaag aaccaagttg
      361 gtccaaccaa cctgataagc aaggttttct gctggagttc tgtcaacttc atcagctctc
      421 ttatctttta aattttctgg aatattatca aattctaaaa tatatttctc aaatgttttc
      481 tctatctcag cttttagttc ttctttattt tcgtatgttc gcaaaaaatc accttctttc
      541 tgatttatca atcctttgat ttaaaatgac cttatttttc tatttatacc ttctaagaac
      601 gctataactg ctgctccaac catcggtatt ccgtatgggc ttaataaaaa acttaatacc
      661 aaagcttcta taccaagtga tacatcttta tattatcatc actaattaag ttaaacagaa
      721 acagacagaa ttattacatc ctgtctccct ttattgtttt tcttcccagt cgtggtaggc
      781 agcgtagagt tgactcttat tccactggta aatcttagct acttccttaa tagcttgatt
      841 tttcttcata ccttgctgga tacgagcttg gatttctaag aacaagtctt cctcgtcttt
      901 ttcttccaca tcctgactgg caccttcaac aatcagaaga cattcaccct tgagagacgt
      961 ttcagcaatg ctttccagca attcagaaat tgtacctctt tggtattctt catagatttt
     1021 ggtcaattcc ctgaccaaga caacggagcg gtcaccgtag acttctagca tattttccaa
     1081 tgtatctgcc acacgatggg gcgattcata aaaaatctga gtttcaggat agtctttttt
     1141 cgagtcgaaa aattgctttt gctggcctga ttttctcggt aaaaagccgt aaaagatatg
     1201 tggctgcggc gctaaaccac tggcaatcaa ggcggaaatt cctgcagagg cacctggaac
     1261 tgtaacaact gcaatttctt cctcaatagc tgccttaacc aaatcatgac cagggtctga
     1321 aatgctaggc aaaccggcat cagagacctg agcaatactt tgccctgctt tcaagaaacc
     1381 aatcaaatca ggaatttttt ccttggcatt gtgctcatga aaactgatct gcttggtgga
     1441 aatgtcaaaa tgcttgagca aaagacctgt attgcgcgta tcctcagcag caatccagtc
     1501 cacttctttc aaggtctgga tagcacgaaa agtcatatca tctagattgc caatcggcgt
     1561 tgccactaga tacagcttgc catagggaga ctgcccctta aaactttttt gaatttgcat
     1621 gcctactccc tgtataacaa ctcatcacag aacatacatt cttcgtcctg ctctcgacgt
     1681 tgtccataaa aatcattaca tacgtgaaat ccatcacggt aaatgcgacg gacactttca
     1741 cgaacatgct tggccttgac aggagcatct gcttccacct cacccaagcg ttctcgcaac
     1801 ttagaatttt ccaaacgaag agctgtattt tcctctacca ggctcttgag atttttcttg
     1861 atggcttcca catcggccaa ggttaccaat aactgttggg aaaaatcatc cagcgcgtca
     1921 aataattctt ttttgtccat aaaacagccc tttcctttct ttatcattca tttttgagtt
     1981 tatatttctt tcaagaccag atattccatg gcattttgaa agctgacatt agcttgccac
     2041 atttttctag cttctagtaa atcttgtaga atcactctta ctcttacctg caagaggtcc
     2101 tgcccacaga gaacttcaag aatccgtaaa acctgatcct gtttttcctt atcatctgcc
     2161 aagttggcta atttggcaac ctgtagataa ctttcttttt tcttagctac taaccaagtc
     2221 agcaggcgtt cactttcatc gaccaaggtc caaaaacttg cctgattagc caacttttct
     2281 gcttcagctc gcgattgact aaacttagct aaaagagtcg cttttttctt aacaagtccc
     2341 atttgttcta agagtaagat aagtttttct tcttgctttt taaagtggaa gatctgagtc
     2401 cgacttcgga ttgtcggtaa catcttttcc tcatcgctag tcaagaagaa aatataaact
     2461 tcactctggg gttcttcgat gaccttgagc agagaattgg ctgcgttggg atgcatttta
     2521 tccgcttgct cgatgataaa gacctgttgc tggctttcaa tccctgcttg agaaaactgt
     2581 cccaccaatt cccgaatgcg ttctgtcttg atgacctgat tgactggctt aatcaaggtg
     2641 acatctggaa actcttcctg ttcaatcagc ttgcaacttc ggcatttctc acatggtaag
     2701 acgccaactt tatccgtaca aaagaggctc ttagctaaaa attgcgctat ttccaagctt
     2761 ccaaagaaac ctgaaaagag ataggcgtga ttgagctggt cttgttctaa gatacggaca
     2821 aaacggtcaa actgagctgg ttgccaagcc tttagttgat cttgtttcat ttggccaagc
     2881 ccattccgtc aaacaagaca gccttggtag tttccacaac ttgctccaaa gggagactag
     2941 catcaatctt gacaatgcga tttccctctt tatccagaag agaaaggtag ccttgacgaa
     3001 cttttttatg caagtccaac ccttccaaat ccaaacgatt aacctcgcgg tcactattag
     3061 cagcaatacg agccagtcct tcttccacct cgatgtcaaa atagagtgtc aaatcgggtt
     3121 tgaggccatc tgtcgcaaac tgattgagcc agtcaatggc ttcaatatct aagccacgac
     3181 caaatccctg ataggcaaca gaactatcga taaaacgatc catgatgacc aacttgccag
     3241 cttcaagggc tggaagaact ttttccacca aatgctgtct gcgactggca atatagagaa
     3301 gtagctctgt tttagcatcc atctgagtat gacttggatc caaaatcact tcccgaatct
     3361 tctccccaat caagactccg ccaggttcac gggtcgtcag cacctctact cctttttcct
     3421 ctaaaattgg tagcagagcc tctaaaacac tggtcttgcc tgctccctct ggtccctcaa
     3481 gagagactaa aaatcctttt gacatgtcta actcatttct tttttactac ttctattcta
     3541 tcaaaaaaat aggggtttgt gacaatcttt ttgtcttctc atttcatact caatgaaaat
     3601 caaagagcaa actaggaagc tagccgcagg ctgtacttga gtacggcaag gtgaagctga
     3661 cgcagtttga atttgatttt cgaagagtat caaccaccat aaaagaggca gataaaacta
     3721 cctcttattt acctagttct tgtgttcgtt tataggcttg atgaactgcc tccatgactg
     3781 tgcctcgaaa agcatgcgct tctaggcttg ctacgccagc aatagtcgaa ccgcctggac
     3841 tacaaacttg atctttcaaa actccaggat gttgctggct ttctaggacc aattgcccag
     3901 ctcctaccac agtttgggct gccattttca aggctgtttc tcgtgataat cccgtctgaa
     3961 cacctgcatc tgccaaggct tcaataaaga gatagacaaa ggctggtcca cagcctgcaa
     4021 gacctgtcgc tgcattgatt aagctttctc ctaattcaac caagagacca gccttggata
     4081 aaagctgaca aaagagctca ctgtcctcag ccctgcaatt aggagacaag gcataactaa
     4141 tcactccttg cccgatagaa gcaggggtat taggcatcat acgaataatt cggtgttgac
     4201 ttgggataag acttgctagt ttttctaagg tcaatccagc tgccatcgaa atcaaaagaa
     4261 gactttctct tttttcaagg atggtctggt attgagaaag cagttcagaa aactgagcag
     4321 gcttaactcc tagaaaaatc acatctgctt ctgcaaacat ttcttcattg ctggaagcct
     4381 gaccaccaaa gtctgcaatg aaagcatcta ccttagcttg actacgattg gcaaggagaa
     4441 tctcatctga cgtcctagtc tgcaagacag attttgccaa gctagcaccc atattcccca
     4501 aaccgataaa tccaatcttc atctcttact cccttatctg cccatcacca gcaaccacat
     4561 acttgtagct ggtcaactct ttcaagccca ttggaccacg cgcgtgcaat ttctgagtag
     4621 aaatccccat ttcacaacca agaccaaatt gtcctccatc tgtgaaacga gttgaggcat
     4681 taacatacac cgctgcagag tccacttgat ctgtaaagta tgctgcagct tcagcatttt
     4741 ccgtcacaat agcatccgaa tgatgggtgc tgtgggattc aatgtgcgca accgcttctt
     4801 ctaaactgct cacaacctta acagcaagga catagtctaa aaactcggtg tcaaagtctt
     4861 gggtctcagc tgcttgacct gaaacaaact ggcttgcttt gctatccaag cggaattgaa
     4921 ttggttccag tccagcttcc ttacgctctg caaccagcat ttgatccaag cgaggaagga
     4981 tgcttgctgc cttgttttca tgaaccagca gaatctccat ggcattacaa acagaaggac
     5041 gactggtttt agcattgttg atgatagaca gcgccttgtc ttcgtctgca tccttatcca
     5101 catagacatg gacaatccca gtccctgtct cgataacagg tacaatcgca ttctcaacca
     5161 ctgcattgat caagccagct cctccacgag gaatgagaag gtctagatag cccttggcct
     5221 tcatcatagc ataactactt tcacggctag tatcctccac cagttgaatc acatttggat
     5281 gaatagtagt cgtctccaag cccttcttca aggctgtgac aatggcatgg gttgtttgat
     5341 aggcatcctt accactacga agaacaaccg catttccact cttaagagtc aaagcagccg
     5401 catcagacgt cacatttgga cggctttcat agataatacc gatgacaccc atagctacac
     5461 gtttttttgt gataaccaaa ccattttcaa gctgacttgt ttctaaaact tcaccgattg
     5521 gatctggtaa ggcaaccact tcacgaattc ctcttgccat cgcttctata cgatctgcat
     5581 ccaaataaag acgatccaac atcacatctg agattttccc cttagccgct gccatatcga
     5641 gggcattagc cgctaaaatt tcctcagtag cagccactaa gtgatcagcc atggctagca
     5701 aggcttggtt tttcacttct tcactagctg tgttaatcga ttttttaaca gcctgtacct
     5761 gttcaaattg ttcttgtcta ctcaccatag tttacctcta aaattctgta aaaagtagtt
     5821 ggatttcagg agtaatggaa atccagtcgt cacggtaaat caagacaccc ttggcttttt
     5881 gagaacgcaa catatcctcc aaagcagatg ctccaaattg cacgcgtcct tttccaagtg
     5941 attttccact ttccttgtca aatactgtca cgatatcacc gtaagaaaag gctccttctg
     6001 cttcaacgat accagataag agaagactct ttccatgttg agagagagct tccgcagccc
     6061 ctttatcaac ccaaatagaa ccttgactct gagcatagaa ggcaagccat tgtttctggg
     6121 tacgaagccc cttctcttga gcaacaaagt aagaaccatc ctcggtctcc tctgccgcct
     6181 caatcatgga atctgatttc aaggatgagc agatataaac aggaactcct gattccgtcg
     6241 cgatagttgc agccttgatt ttggttaaca tacccccagt tccgtttgac gaacctgctc
     6301 caccagccat atcaataatc tcacgattga tggtctcgat tctctccaag cgtttggctc
     6361 ttggatctga attaggattt ccagtataga gaccgtccac atctgtcaag aaaactaaaa
     6421 ggtctgcttg gaccatcgcc gctacttgag cacttagagt gtcattgtcc ccaaccttga
     6481 gctcatcaat aacgacacta tcattctcat tgatgatagg aattgcccca cggttgagca
     6541 aaaccgacaa agcctgatgg gcatttttat aacgacgctt atccacaaag tcatcttggg
     6601 tcagcaagat ttgtgcagaa acgatttgac gcaagagaag attggtcgta tattcttcca
     6661 acaaaagtcc ctgccctacc gctgctgaag cctgtttatc agcaatttta gtcggacgct
     6721 ttttaaatcc taaggctcca aaaccagccg caatggcacc tgaagacacc aaaatcaact
     6781 catgaccagc ctcgtgcagc atagccaact gctgggtaat atcctttacc ttactacgtg
     6841 ataaacttcc atcctcattt gtcagagaag aagtacccac cttaaagaca atccgtttgt
     6901 atttcatagt ctcactccga ttattcatat ttatccatta taacatgaat aacaggaaat
     6961 agaaaagagt tgataggaaa aagaaggccc taaaaccttc ttttctacta ctgttctgat
     7021 tccgatttgt ttacactcgt ttcagagctt tgtgaagttg aggatgtcaa atcttgacta
     7081 gttgaagaat ttgtaacact ttcatgttga ctcgtttctt tattttcaag atcctttttc
     7141 actacttctt tggattcttt tatttctgaa tgacttgtag ttttaattgt agcagatttc
     7201 tcgatcggaa catccactaa ccaggcacca cttgaatcca cagtatagcc ttctggtgtc
     7261 ttaccattca caagtaattg accattttct ttcaagaagt accatttatc cttctcttta
     7321 atccaaccta tagctcgtga accatctgtc ttgtagaaat accaatcatt tgccttttta
     7381 agccagcctt gcttcatagc tcctgattct tctagatagt aatgatgtcc agcaacttct
     7441 atctcacctg tcttcatgat accagtagaa tccatatagt accaggcttc tttatctttt
     7501 acccagcccg ttttcatttc ccctgatgga gcaaagtaat accattgccc cttatattga
     7561 agccaacctg tcttcataga gccatcaaca tccaaataat accactgctc tttatcttga
     7621 atccaaccaa tttccatctg gttttctttg ttaaaataat accagattcc agcgattttc
     7681 ttccaatttt tagcagcaac accagagtct gtcaaataga accaatgatt gttccatttt
     7741 ttccattgat tctgtaataa gatacccgtt tggttaaagt aataccattc acccttaatt
     7801 tcattccaac cgacagcata ttctcctgta gaatcaggcg cttgatacca ccagtttcca
     7861 tatgaactct tatgccaacc agcttgaaaa cttggaatag gcttgtagga tgttgaaata
     7921 ttgacaaaac cgtcttttcg aatatcaaaa actgtcgcat catagtcttt gctggctgcg
     7981 ttgattctct caattcctcg ttctttgagc caattaacat actcactatc aacaccattt
     8041 ttccaaggta gactatccga agtttgaaca atcaaactcg gactcaaatt tttaatgaaa
     8101 tccttggtat ttgatttatt ggtatcatgg tgatgattaa acttcatcaa atcaactttt
     8161 ccaatgagag gaccatactt gtcttctgct ccatgaacat tatctaaatc gcccccaagg
     8221 taaattttct tgccattgac tttcaccacg ctaatcaagg aattggaatt gtcatcccaa
     8281 attttcttta attcacccga tgaatcagtt tcattttcat aattatagag ctcaatatcc
     8341 atatccccaa actgaaaatg agcatcccct tgtgtgatat tttgaataac tgaaacacct
     8401 ttttctgcag cagtctgtaa aaccttatca tagccataca gattatccca tagacgttca
     8461 gaattagtaa tacgactatc actatatttc ttaagataga ctcggtcaac tggataggta
     8521 gacagtaatt catcaacatt tccaatatga tcactgtggg tatgggtcac caaaataaaa
     8581 tcaagttttt ggacacccaa ttccttcaaa tgacgaaaga cacggtctgt cagaacatgc
     8641 ttataagacg tttcaattcc ttctctccat ggatagcgag aatcacttcc atctgggaaa
     8701 tcataatctt ctcctgtatc caccatggca aaatgtccat tgctttcaag aataatcgca
     8761 tcactgccac cttcttgaac attgataaag tggattttat ttcctgaact ttcttgagcc
     8821 tgaacattcc cataccatga caaacctaaa aaagcgccta caagtgctaa actagttaat
     8881 ttctttttca ttcttacttt ctcaatctct ccaaggtttc cttaaaaatc tctgggatat
     8941 ctgctttaaa ttccaaggtc ttacctgttc tcggatgagt aaaacctaaa gtcttggcat
     9001 gaagaaattg tccatgtcct ttcaaagtct ttcgaggacc atagacctca tcaccagcga
     9061 ctggatggcc gatataagcc atgtggacac ggatttgatg agtgcgccct gtctccagtt
     9121 gcaactctac taagctataa tcgccaaagc gttccaagac gtgaaaacgc gtcactgcag
     9181 gcttcccttt agcagttaca gcctgtttct tacggtcttt ttcactccgg ccaatcggcg
     9241 cttcaattac accacgatca ttaggcagat ttccatgaac aatcgcccaa tatttgcgga
     9301 gagacttttt atccttgagt tcttgggcaa gtgctagatg cgcatcatcg tttttagcaa
     9361 tcatgagaag acctgacgta tccttatcaa tacggtgaac aatccctgga cgcagaaccc
     9421 cattgatacc cgacaagtcc ttaatatgat acatgagggc atttactagg gttccactgg
     9481 tatgaccagc actcgggtgc acaaccattc cctgaggttt gttaacgaca gccacatcct
     9541 catcttggta gactatttct agcggaagat cctcagccac atactctaat acctctggtt
     9601 ctggcacatg gtaagtgacg acatcaccct cttggactgt gtatttagct ttcttgactt
     9661 gaccattgac caagacctgg cctgatttaa tttgttcatt cgcgagacta cgtgataatt
     9721 ctgacaaatc tgacaaagcc ttatccaaac gcagaccacc agtttcaatt ttaatttcca
     9781 tttatttcct cttttagtat tgcaatcaat aaaataatca ctccaaccgt cagatagcta
     9841 tctgccacat tgaaaattgc aaagttgata aagtcaaggt ggaacatatc cacaacaaag
     9901 ccctgactga ccctgtcaat aaagtttcca agaccacccg cgattattag agtcaaaccc
     9961 aagaccatcc agaatgagtc ctccatgtgt ttatgtaaat accaaatggc acctatcacg
    10021 acaaccagag taatgacggc gaataacaac tgctgatctt gtaagataga aaaggctgca
    10081 cctcgatttt gcaggtaggt caagctaacg aaattgggga tccaggagcg cacttcaccc
    10141 agtggaatct gctggacgat ataggatttg accaactgat ccagcccaat caaaagcagt
    10201 acaatgactg ccactattgc tctttttttc atgatttcct cttttgatca aaatattctt
    10261 gcatgacttc tacgaagaga gtcccagctt gactaagctc cacttcttca cgtttaacat
    10321 agaccatgcg gttatctagg ttatccttga gacgaataac tgtaatgcca ttaacactgt
    10381 cactatctaa aaatccagaa cctgtcgcat aggcgtccgt ccgctccaaa ataccattca
    10441 aggtggcacg gtctgtcaca ttaaacatct gtgagctagc gctggtatca acaaagttct
    10501 ctgaataata aaggtactcg tctttctctt gagtgaaacg aaccgttggt aaatccgcta
    10561 aatcctccat gactaattcc tctttctggg ctaaaggatg accctcacag agataaatat
    10621 gggtatggaa aggaatcaat tcgatgacct ccagacctaa cttttcaacc cgttgcataa
    10681 tccccttttt attttgattg ttgaggtaga taatcccaat ctcactatgc ccttgcgcca
    10741 cttcatctaa tatttgaaca gtagttgatt caaaaatacg gaagttctta tagtcaggat
    10801 agcgctctga aaaggccgta atagttggtg gtaagaagtc atagtgctgg ctagcaacgg
    10861 aaaattcatc tttttcttct tcaggattgg catactgatt ttgaaaaata tcaaatcctt
    10921 taaccaattc ttgcgctttt tcataaaatt ccatcccacg acgggtcaag aaagtccctg
    10981 agctggtccg acggaaaatc ttaaagccca actctttttc caaatcacga acagaaatag
    11041 acagactcgg ctgactaaca tacatctttt cagcagcttc acgaaaagta ccactattgg
    11101 caatagccac aacatagcgt aattgttgaa tgttcatctt ctacccccaa cttctttatc
    11161 ttttcattat accatatttt agaagttttc caaaaaggaa aaaagaacat cctattcttc
    11221 ttaactatct tcactatctg cctttctcac gccaatctta ttttcaaaat caattcaaaa
    11281 aaataagtgg ctacacacca cttcagtatc ggaaagaaaa acgttgacta tttgtgaaaa
    11341 aagaaaatgc cggaaaattc cgacattttt ttagtaagct aacttcctga aaataggagt
    11401 aaccaaacat cccagaaggc agtgatattg atgagaatat gaactagtat tggatagtag
    11461 agatttttag tcatgcgata caatagagct aaaataagac ctccactagc ataaatgaaa
    11521 aaagcaagag gagttaaagc aaaattgata tgaatataac cgaaaataat agcagaaagc
    11581 aaaacatctc cgtaccaagg tgagtttttg aaaaaggttg tcataagcac acctcgataa
    11641 atcaattcct cagcaatagg ggcgatgaag caaacgatga gcaagaaata agggaactcc
    11701 tgtctcccca tcatttctac cgtttcattc aaagaaatct gatttgaaga cagggatatg
    11761 aaatacgaaa agaggaagtc agacatatat gaaatgatgt agcccagtaa aaggtagatg
    11821 aagtacctca gctgccactt gaaatgaaaa attttctttc ctgcaaaaac cagtagatag
    11881 atgaccgcta agaaaagaac tccgctctcc atcaaaagca gaatctgaaa aaattcacga
    11941 cttgctggta gatagggctt tgcgaggtga ttgaaaactc tccaaaacca agttgatttg
    12001 taaaaaatta aggacaatgc tagtaaaatt tgaatagccc gttttttcat attaaattct
    12061 ctgctttctc cccttgtttc ttcatattac taataaattt tacttaaaat ctcgcagcac
    12121 ttcctttgca aagatgattg cctcctccaa tatatcctaa atcataggtg cctctgggac
    12181 aaaatccatg aaccggcaga gttaatactg gttctatttc ccaatcgtac ctaccattag
    12241 gatttttacc atatgaatct gctccacctt gtatcagctc taattcttca tttgttagat
    12301 ttatattttt tgtcattaaa atcatgatat atttcctcca ttattcttca gattagttga
    12361 gtaatctgat actcatacct acttacaaaa aaactattat attaagttgg ttttttaatt
    12421 tgtctagttg caacattgac aaacatagta tagcatatct ttgcgaaata tcctcttcaa
    12481 atcatgaatt gtcatcaaaa catcttaaac tataaaatca attagtctca agctttctat
    12541 caatttcttc tccaaaatat gctataataa tagcaaaaga taaagaagga agacctatga
    12601 ttaaactact agccttggat atggacggca ccctcctcaa tgaagccaag gaaatcccac
    12661 aagctcacat tactgctatt cacaaagcca ttgaaaaagg tgtcaaactg gttctctgta
    12721 cgggtcgccc ccttttcggt gtcctcccct actacaaaaa actggagctt gacctccaga
    12781 acgaatatat tattgttaac aacggttgtt caactcacca gactagcgac tggggcttgg
    12841 ttgactggca agaactgagt ccagctgaca tcgaatacct ctatgacctt gctgaaaaga
    12901 gtgatgttca gttgacactt tttgacgagt cacattattt tgttctcggt ggcaaaccca
    12961 atcaagttat tgaaaatgat gctaaactag tattttcaga cctgactgaa atttctcttg
    13021 aagaagcgac tagtggaaag ttccggatgt tccaaggtat gtttttagga acaaaagaac
    13081 aaacagacga ttttgagcag cgttttgctg aagagctttg ccaacgattc agtggagttc
    13141 gttcgcagcc tgtcatttat gaagcaatgc cgcttggaac gacaaaggct actgctcttt
    13201 cacgactagc tgagattttg aagattgatt cctcagagat tatggccatg ggcgatgcta
    13261 ataacgatat cgaaatgctc cagtttgcag ggcttgggat tgcaatggga aatgccagcg
    13321 attatgtcaa atctcttgcg gatgccgtta catcaagcaa cgaagaagac ggcgttgcgc
    13381 gtgctattga gaaatatatt ctataaaaaa gaaaagcaaa tagacagaag ttactgctat
    13441 ttgctttttt gctaatattt taaaatacgg actaatcaat agacaagaat agcgaatcat
    13501 aaaaatcgat ttactagatg ccatagtatc ttatagttgc taataagaag ttagtctagc
    13561 agaatgaatc tctcatttct cccacactaa tctgtaattt gtctatacat ttctggtctt
    13621 ctatctcgaa acaagcccca gtttaggcgt tcacttgctc ccttgtctag gtcataagta
    13681 gctaacagaa cagcttcttc ttgtctttca gctcgttcta gaatagctcc tgtttcatcc
    13741 gtcataaagg aggaaccgta gaagtcaaga ctggaactct gtccgccatt ttcctcacta
    13801 ggagtaacct cctctaaacc ataacgattg gctgcgatga ctggaacaat attcgctgct
    13861 gcgtgccctt gcatagtacg ttgccagtga ccacaactat ctgtatccaa aattggctct
    13921 gaaccgatag ctgtaggata aaagagcaat tcagcaccat tcaatgcaag acagcgcgct
    13981 gtttcaggga accattgatc ccaacagata ccgataccaa tcttagcata gcgagtattc
    14041 cagaccttga aaccagtgtt accaggcgtg aaatagaatt tttcttgata ataatggtca
    14101 tctggtatat gggtctttcg ataaacgccc agcacttccc catctgcatc aatgacggca
    14161 atagagttat acaagacatt accatctttt tcatagaaac tgattggtaa aacaacttgt
    14221 agttccttag caatcacctt aaaatgctga atggcagtat tttccgctac agattgggca
    14281 tactggtagt agtcatactg acgttcctga cagaaatagg gatgttcaaa caactcgggc
    14341 aagagaataa tttgggctcc ttgctcagca gcctgacgta ctaaacgctc tgcggtttgg
    14401 atatttgttg ccacatcctt agcgcattgc atctgaatgg ttgcaactct tacatttctc
    14461 atctttttct cctattctgg aatttgttgg gtgatacagt ggatattgcc accacctaag
    14521 agaatatctc tggctggtat tccgacaact ttacggtctg ggaaacactt gctgaggata
    14581 tctaaggcca cttggtcgtt tacatcctca aactgtggaa ccaagacagc cttgttggcg
    14641 atataaaagt ttacgtagga agctgctagt cgttcacctg cgtatcgctt ttcttctcct
    14701 tcttcataga tgtagcctgg caaatcttct tctgtcacaa cttgtcgaac tgcagggata
    14761 ggcaatttat gaatggtgaa gtgacaacct tttgcatctg tttcctgttc taagagttcg
    14821 agatctgctt ttgacatggc atactgggga tcattttcgt catctgtcca agccaaaaca
    14881 agctcagcag gaccaacaaa ggcagcaaca ttatcgacgt gttcattggt ttcatcctga
    14941 taaataccat aaggaagcca aataactttt tcagcaccaa gactttctaa taatgtgttt
    15001 tcaatctcct ctttagtcag gttaggattg cgaccaggac taagcaagca actttcagtt
    15061 acgagaatag ttccttgacc atcgctatgg attgcgcctc cttccagtac aaaaggttta
    15121 gcatcataga caggcctttc caaggcctca gcaaaacgac tggctacttg gtcatcctct
    15181 tcataatctt gataaagacc atcataggtg cctccccaag cattaaaggc ccaatccacg
    15241 gctaatttct tacctttatc attgacgaga atggttgggc cagtatcacg cgcccaggca
    15301 tcattggtgg gaatgtctaa ataaacaacc ttgtctccaa gataggattg ggcttcagat
    15361 agataggcct gctccaccaa aagatagact ctttcccctt ctgctatggt ctcgatgatc
    15421 tgagtaaatg ctcttttagc agcctttcct tgaaaaggcc atgatcctgg tcgagtcggc
    15481 catatcatga gggtaccatg atggggttcg tactctgctg gcatgtgata gcctaatttt
    15541 tttggactgt ccatcatgat aatctccctt taaagtcttg atagccaaaa gctttgagta
    15601 agctacagtc tccctgttcg tccatgagat agagacttgg taatccaata ccattaaagg
    15661 tattattttt gacaaaagaa taaatggcca tgtcttgaaa ataaagtctg tctccgattt
    15721 ggactggatt ttcaaaacta taatcaccaa tcacatcgcc agtcagacaa gtattagaag
    15781 aaagtctgta ggtatgggct ttttcctgtg cctcaaagcc atttctcaaa ggtggacgat
    15841 agggcatctc aagtacatca ggcatatggc aggtcgcaga ggcgtctaaa accaagattt
    15901 ccataccgtt ttctacaata tctaatacct cagttgctaa ataacccgca ttaagcgcaa
    15961 tggcttcacc aggctcgata tatatttcaa gattgtaagt ttttcggata cgcttgattt
    16021 ctgaaatcag caaatccaca tcgtaacctt ctcttgtaat atgatgacca ccacccatat
    16081 tgagccattt tacctcatgt aagtagggac caaactgttc ttctactgct ttcaaagttg
    16141 tttgtaaatc atctgctccc tgctcgcaaa gggtatgaaa atgaagtccg tcaaccaaat
    16201 ctagcaaatc actcggaatc ttgtctatag taactccaaa gcgagaacct ggtgcacaag
    16261 ggtcatagag cgcgtgatct ccttgagttg aacactgagg gttgaggcgc aaaccaacac
    16321 tgacaccagc ctctcgacaa cgagccccat gcttacgcaa ctgtctctct gagttaaaga
    16381 cgatatggtc tgttatccca agcaattcct ccaagtctgc atccttgaaa gcaggcgcaa
    16441 atacatggac ttcaccagga aattcttccc ttgccaattt ggcctcatag agtccactag
    16501 ctgtcgtacc tgatagatac tggctaatca agggataagt tttgtagagg gaatatgcct
    16561 tctgggcaag caagaccttg caaccgacct cttcttgtac atattgtaga atgcggcaat
    16621 tagcttctaa cttggccaag tcaataacat aggctggtgt tggtacttgt tctaacttca
    16681 ttagtccacc atttgtggat tttcaaccac aacccatggc aaaccatact cattcaaagc
    16741 ttccatgaat ggatctggat ctaactcctc aaggttatac actccagctt gtttccaagt
    16801 tccgttcatg actaattttg tcccaatcat ggctggaact cctgtcgtat aagaaatagc
    16861 ttgcgaacca acctctgcgt aacattcctg atggtcgcag acattgtaga tatagatagt
    16921 ctttttgaca ccgtctttga cacctgtaaa gatacatcca atattggttt ttccgactgt
    16981 acgtggccca agactggcag gatctggaag caaggctttc aaaaattgaa ttggaacaat
    17041 ttcttggccg ttaaagttaa tggtatccgt acgaaggagt ccaacatttt caagacattt
    17101 catgtgcgtc aagtaagatt gaccaaaagt cataaagaaa cgaatgcgtt tgacacctgg
    17161 aatgttcttg gccaatgatt cgatttcttc atggtgaagg agatacatat ctttttgtcc
    17221 aacttgaggg aaatcatact cacgcttgat agacatagct tcgacttcga cccatttccc
    17281 atcttcccag taagaacctg gcgcagaaac ctcacggaga ttaatttctg gattaaagtt
    17341 ggttgcaaat ggataaccgt ggtcaccgcc attacagtct aaaatgtcga tataatggat
    17401 ttcatcaaaa tagtgtttga gggcataagc tgaaaagaca ctagttacac ctgggtcaaa
    17461 accagaacca agaagagcag tcaagcctgc ttctttgaat ttctcttgat aagcccactg
    17521 ccatgagtag tcaaagtagg ctgtaaaacc aagttcctta caacgttttt cgtagatagc
    17581 acgccactca gggtcttctg tgtcttctgc ttcgtagttg gctgtatcga tatagtgaac
    17641 acctgttgcc aaacaagcat ccataatggt taaatcttga taaggcagag ctacattcaa
    17701 aacagcttct ggtttgtagc tttcaatcag ggcaatcact tcttcaacct tgtcagcatc
    17761 aagtgctgca gtttcaattt tagtacttgt tttgccttct agcttcgctt tcaagtcatc
    17821 gcattttgac ttggtacggc tagcaatcat aatctctgta aatgtttcgc tatcttgaca
    17881 aatctttgaa atagcaactt gggcaacgcc cccacaacca ataactagta aacgactcat
    17941 ttttttcctt cctcttcttc taaaatgtcc tcaacatact tgggcaacat aaaggatccc
    18001 acgtgtaagt ttgcagtgta gtattctgtg aaaagctggc gttttttcca accttccttg
    18061 tcaaaatctt tgacagggtg gtattttttc gatgcaaatc caaacaacca atagccagct
    18121 gggctagttg gaatatgggc ctgataaacc cgactgattg gaaaggattg attgaccttg
    18181 cggtgcatgc ttcggcaggc cgactcatcc tcgtcaaaga agggactccc atgctggtaa
    18241 atcatgatgc cgtcttcctt cagagctcga taactattgc cgtagaattc cttggtaaag
    18301 agtccttccg tatggccaaa tggatctgtc gcatcgttga tgataatatc gtaatcatct
    18361 tcgcagtttc gcaaaaagcg tagcccattt tggtagtaaa tggtaacacg aggatcatct
    18421 agccctgcag caaagtctgg gaaatactca cgacagacct cgaccaacat ctcatccggt
    18481 tccacgatat cgatttgttc cagttcagga tagagtgtta atacttgggc aacaccgccg
    18541 tcaccacccc caataaccaa tactttcttt ggatttgggt ggacagccat gggaacgtga
    18601 acggtcattt cattgtagac gaaatcatcc gcatctgaga acaagacatg gccatttaaa
    18661 atcagtattt tcccaaaagc tggcgtatcc aagacttcga tatcctgcca ttcacttttt
    18721 ccagcgtaaa gttgcttggc tgttctcaga gacaatttga catctggagt atgaacttca
    18781 gaaaaccata aatccatcta tttctcctta tattatattt agcgcagtta gctactgcca
    18841 aagcccaagt ggtatacttg gaataagcca ctgtggatta gtttattccc tccaatcgct
    18901 tgacgatttc cgaaaggctc taaccacagc ttttgtttca attggtaatg agtttgataa
    18961 cgcatagacg ttttatctcg tctaaggtaa caaggcaaaa agttcgtgga taaccaagta
    19021 gacttgaaat actatatctg gaggtactcc catgctttat gtgggcattg atgtcgctaa
    19081 aaataaacac gatgttacag ccttgaatgt tccaggaaaa ctgttcttaa accactcact
    19141 ttttcaaata ataaagctgg ttttgaactc ttagatctgt ctcttcgaca gctcaaccaa
    19201 gactgtctca tcgctcttga agatactgga cattatgcct ttaatctact gaacttcctg
    19261 catgaacaag gatataaagt ttacacctac aatcctttgc tcatcaagaa atttgccaaa
    19321 tcattattac ttcgcaagac taaaacggat aagaaagacg ctcatggcat cgctcttaaa
    19381 cttctttctg atcccaatcg tgaacaattt caacacgata atcggcaagt agaactaaaa
    19441 atactggcta gacatattca tcgtctcaag aaaaaacagt ctgattggaa agtgcaatac
    19501 actcgttgtc ttgatatcat ctttcctgag ttggataaaa tcgttggaaa gcattcagaa
    19561 tatacctacc aactcttgac atgctaccct aatcctcaga aaaggattga ggcaggattt
    19621 gataagctga tagaaattaa gcgattgacc gcttctaatt caagggcttt ttgccgtgct
    19681 ctaaaatcat cgccaaatca tcaaattgaa ataagaaata gtttagataa aactattgac
    19741 ttttcttata gtttgtcttt ctcttaataa cgttgatatg attgacctct ggatcttccg
    19801 tcccttggag ggagcaacca cgttccttgg cgaattggat atagtctaca atttctcgtg
    19861 taatgcgttc accaggagcc aagataggaa tccctggagg atagcacatg acaaattctc
    19921 cacagacctg tccaacagac tcatctaagg tcaaactttt tctctctgaa tagaaggctt
    19981 cttgtggaga cagcaccaac tcgggctgaa tatattctcc agctattaag tccttcccat
    20041 ctcgtgaata gagtctctta atatcagcca gagcaccaac caagcgctcg atgtcttgga
    20101 tgcggtcgcc gatggaaata taggccaaga tattgccgat atcaccaaac tcgatctgaa
    20161 tgtcgtattc gtctcgcaag aggtcataaa cctcgatacc tgttaagcct attccctgag
    20221 tgtaaactga caacttggtt acatcaaaat cacagaccga cacaccatct attaactctt
    20281 ttgagtaagc atagtaaccg ccaatggcat tgatttcatg acgagcgtac tcggatagct
    20341 caatgacttc ctcaaacgac tctttaccac gaagggccaa gttgcgacgt gaaatatcca
    20401 aactagccat caataagtaa gaggcagatg tagactgggt caggtttata atctgacgaa
    20461 cgtactcggg attcatctgc tccccgatta aaagaagcga actttgtgtc aaactcccac
    20521 cagacttatg catggaaact gctgccatat cagctcctgc atccatagca gaaattggaa
    20581 gtttaccagt gaaatgcaaa tgcgctccgt gggcttcatc tactaaaacc atcatgccag
    20641 cttcatgagc catttctgtc aaccccttta ggtctgaaca gatgccgtag taagtaggat
    20701 tgttgattag gatagcctta gcatctggat ggtcctttat ggcctgtgct actcggtcat
    20761 tttcaagacc taaagcgata ccaatcttag gatctacact catctcgata tagatgggaa
    20821 tggcaccaca tagaaccaac gcattgatag cagatttatg gacatttcgt ggcagaataa
    20881 tcttatctcc tgccttgcag gttgccagaa tcatagtctg caccgatgaa gttgttccac
    20941 caatcattag aaaggcatgg ctagatccaa aagcatctgc agccagctcc tctgcatcac
    21001 gaataatcga aataggatgg cctaaattat ccaagggttt catcgaattg acatcaatgc
    21061 ctacacattt ttctcctaag agttcgacaa gttctggatt tccccgtcca cgcttgtgac
    21121 ctggaacatc aaagggaaca atccttttct tgcgtaactt caccaaggcc tcataaattg
    21181 gggcttggtt ttgatctaac tctttcaaaa catactcctt tcaatatttt taggacctta
    21241 tgaaaactaa ggaactaaag gttgactcat gaaaaaagag caggttttca cctgctctgc
    21301 aatcttctga cgtgtttatt ttggtttctg ttgagtatgt ctgttcccga tgtttcctaa
    21361 ctctctagta gcaaatatta cgtactttat tgatcgtttc acaagatgac gtgtgctttc
    21421 accacactaa aaatttatga attagaacaa gtgtcctaac atcaacttat aaaagtaggc
    21481 ttttaaccct atcaataatg tggcttttca accacgcttc ggcattcaac cctgcctgtc
    21541 cgtaggcatt ttttactcgg gtttatattt gctagaaaac atcatctcat tttctaagct
    21601 ttattactat atcatgtttt taagaacttg taaagtattt tttgataaaa aa
//
LOCUS       DAVHSO010000034        21357 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.034, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000034 DAVHSO010000000
VERSION     DAVHSO010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21357)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21357)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21357
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.034"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            173..649
                     /locus_tag="VVR18_001306"
     CDS             173..649
                     /locus_tag="VVR18_001306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6032825.1"
                     /translation="MVLDYFFDKNLVFCLEADNQEQLFDQVATLLEEREIVTPTYREA
                     LITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDK
                     EVEVSLLFFIINNSSSSQTNILAQLMDFFTGNGHLEDLSKISEPEKLYAYIAEATA"
     gene            687..989
                     /locus_tag="VVR18_001307"
     CDS             687..989
                     /locus_tag="VVR18_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU6032826.1"
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFCIPAMSVPVFDNIRLPAKQNMV"
     gene            997..1782
                     /locus_tag="VVR18_001308"
                     /pseudo
     CDS             997..1782
                     /locus_tag="VVR18_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            1831..2295
                     /locus_tag="VVR18_001309"
     CDS             1831..2295
                     /locus_tag="VVR18_001309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase"
                     /protein_id="HEU6032827.1"
                     /translation="MGGHPGFNCPLLDDEVYEDYYLEFEKEEICSVPRPFPETGMLDF
                     QDRSPCLEGQKEIDLSYDLFSTDAVTLDELQSRTIALRSLKHDKGLKVHFAEFPNLII
                     WSTLNKGPFITFEPWSGLSTSLEEGDHLEDKKNVCLLEANQVEELGFEIEVL"
     gene            2452..2877
                     /gene="lacA"
                     /locus_tag="VVR18_001310"
     CDS             2452..2877
                     /gene="lacA"
                     /locus_tag="VVR18_001310"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HEU6032828.1"
                     /translation="MSIVIGADAAGLRLKEVVKNFLEKENFHLVDVTAEGQDFVDVTL
                     AVAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMIT
                     MGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     gene            2908..3423
                     /gene="lacB"
                     /locus_tag="VVR18_001311"
     CDS             2908..3423
                     /gene="lacB"
                     /locus_tag="VVR18_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HEU6032829.1"
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPI
                     FGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNAN
                     VIGFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHLESHNAQQTDANFFTEF
                     LEKWDRGEYHD"
     gene            3434..4363
                     /locus_tag="VVR18_001312"
     CDS             3434..4363
                     /locus_tag="VVR18_001312"
                     /EC_number="2.7.1.144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="HEU6032830.1"
                     /translation="MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTR
                     VLSEFGDSVLATGLVGGKLGEFLVEHIDNQVKKDFFSIQGETRNCIAILHGDNQTEVL
                     EKGPEVLEQEGQDFLEHFKKLLESVEVVAISGSLPTGLPVDYYASLVELANQAGKPVV
                     LDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWI
                     IVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKA
                     NVLGMLNAQEKMTGHVNMANYQALYDQLIVKEV"
     gene            4365..5345
                     /gene="lacD"
                     /locus_tag="VVR18_001313"
     CDS             4365..5345
                     /gene="lacD"
                     /locus_tag="VVR18_001313"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HEU6032831.1"
                     /translation="MALTEQKRVRLEKLSDENGIISALAFDQRGALKRLMAQHQTEEP
                     TVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTK
                     RLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPF
                     FLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGF
                     AEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLC
                     GRATWAGSVEAYIKDGEAAAREWLRTTGFENIDELNKVLQTTATSWKERV"
     gene            5579..6415
                     /locus_tag="VVR18_001314"
     CDS             5579..6415
                     /locus_tag="VVR18_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEU6032832.1"
                     /translation="MYRILNPMNHNVSLVRNDKGEEVIVIGKGIAFGKKKGDLITENQ
                     VEKIFRMKTEESRENFMALLKDVPLDFITVTYEIIDKLSKKYHYPIQEYLYVTLTDHI
                     YCSYQALTQGRYKDSNLPDISAKYPVAFQIANEAFEIYRQKLADHFPEDEIIRIAYHF
                     INAEGENEVELVESIDKRKEILRNVEEVLTDYAIQRTKKNNHFYDRFMIHLNYFLDYL
                     DRSRDDNQSLLDMEDHIKQSYPKAFEIGSKIYDVITQHTGLDLYKSERVYLVLHIQRL
                     LS"
     gene            6451..6768
                     /locus_tag="VVR18_001315"
     CDS             6451..6768
                     /locus_tag="VVR18_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU6032833.1"
                     /translation="MNREEVTLLGFEIVAYAGDARSKLLEALKAAEVGDFEKADALVE
                     EAGSCIAEAHHAQTSLLTKEASGEDLAYSVTMMHGQDHLMTTILLKDLMHHLIELYKR
                     GVK"
     gene            6768..8459
                     /locus_tag="VVR18_001316"
     CDS             6768..8459
                     /locus_tag="VVR18_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEU6032834.1"
                     /translation="MNKLIAFIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIF
                     ILIAFVPNSWGFKWSDEVVAFLMKPYSYSMGILALLVAGTTAKSLTDSVNRSMEKTNQ
                     INYMSTLLAAIVGLLMLAADPIENGLATGFLGTKGLLSAFLAAFVTVAIYKVCVKNNV
                     TIRMPDEVPPNISQVFKDVIPFTLSVVSLYALDLLARHFVGSSVAESIGKFFAPLFSA
                     ADGYLGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILT
                     SGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLV
                     LNPIFFIPFIFAPIANVWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQVLSFI
                     LAALLIVVDVVIYYPFLKVYDEQILEEERSGKSNDELKEKVAANFNTAKADAILEKAG
                     VDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPE
                     FDLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQEQFD"
     gene            8674..10080
                     /gene="lacG"
                     /locus_tag="VVR18_001317"
     CDS             8674..10080
                     /gene="lacG"
                     /locus_tag="VVR18_001317"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEU6032835.1"
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWY
                     TAEPASDFYNRYPVDLKLAEEYGVNGIRISIAWSRIFPTGYGQVNAKGVEFYHNLFAE
                     CHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVDYAAFCFEEFPEVNYWTTFNE
                     IGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLYKEKGYKGEIGVVHAL
                     PTKYPLDPENPADVRAAELEDIIHNKFILDATYLGRYSAETMEGVNHILSVNGGSLDL
                     REEDFTALEAAKDLNDFLGINYYMSDWMEAFDGETEIIHNGKGEKGSSKYQIKGVGRR
                     VAPDYVPRTDWDWIIYPQGLYDQIMRVKKDYPNYKKIYITENGLGYKDEFVDNTVYDD
                     GRIDYVKQHLEILSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERY
                     PKKSAHWYKKVAETQIID"
     gene            10170..10382
                     /locus_tag="VVR18_001318"
     CDS             10170..10382
                     /locus_tag="VVR18_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3884 family protein"
                     /protein_id="HEU6032836.1"
                     /translation="MNFEKCSQIPCLTSEELKSLGKWYVSTGKEWICHSDDELEEFKN
                     LFLNFINPEEWDTISFDSDFMPFQQS"
     gene            complement(10661..11422)
                     /locus_tag="VVR18_001319"
     CDS             complement(10661..11422)
                     /locus_tag="VVR18_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000917571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU6032837.1"
                     /translation="MLKQEKLTKILEIVNSKGTITVKQIMDEIAVSDMTARRYLQELA
                     DKDLLIRVHGGAEKLRTNSLLTDERSNIEKQALQTAEKQEIAHFAGSLVEERETIFIG
                     PGTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTL
                     QNLSNLQFSKAFVSCNGIQNGALATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDF
                     YTFYNISNLDTIVSDSKLSDSILFKLSKHIKVIKP"
     gene            complement(11604..12566)
                     /gene="nrdF"
                     /locus_tag="VVR18_001320"
     CDS             complement(11604..12566)
                     /gene="nrdF"
                     /locus_tag="VVR18_001320"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HEU6032838.1"
                     /translation="METYYKAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDW
                     RKLSNKEKDLVGKVFGGLTLLDTMQSETGVQALRADIRTPHEEAVFNNIQFMESVHAK
                     SYSSIFSTLNTKAEIEEIFEWTNTNPYLQKKAEIVNEIYLNGSPLEKKVASVFLETFL
                     FYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEEEQEKLK
                     EWMYDLLYTLYENEEGYTESLYDGVGWTEEVKTFLRYNANKALMNMGQDPLFPDSAED
                     VNPIVMNGISTGTSNHDFFSQVGNGYLLGEVEAMQDDDYNYGLD"
     gene            complement(12754..14913)
                     /gene="nrdE"
                     /locus_tag="VVR18_001321"
     CDS             complement(12754..14913)
                     /gene="nrdE"
                     /locus_tag="VVR18_001321"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000523276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HEU6032839.1"
                     /translation="MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVV
                     PNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLEELAQFIKDQNFQFKSFMAAYKF
                     YNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLN
                     AGRARRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGY
                     EGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVR
                     VKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYIDITEKYDELVANPNI
                     RKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPVDGKIIMSNLCSEILQVQEPS
                     LINDAQEFLQMGTDVSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPT
                     IDHGNSQAHTFGLGAMGLHSYLAQQLIEYGSPESVEFTSIYFMLMNYWTLVESNNIAR
                     ERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELFKNVFIPGVADWAELRDKVQ
                     EDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETI
                     PYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFMRSDIPKGLYEWKRENKQTTRDLS
                     ILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI"
     gene            complement(14994..15212)
                     /gene="nrdH"
                     /locus_tag="VVR18_001322"
     CDS             complement(14994..15212)
                     /gene="nrdH"
                     /locus_tag="VVR18_001322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin-like protein NrdH"
                     /protein_id="HEU6032840.1"
                     /translation="MVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKE
                     LGFSAAPVIQTPTEVFSGFQPGKLKQLA"
     gene            15563..15826
                     /locus_tag="VVR18_001323"
     CDS             15563..15826
                     /locus_tag="VVR18_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019775469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocarrier protein HPr"
                     /protein_id="HEU6032841.1"
                     /translation="MASKDFHVVAETGIHARPATLLVQTASKFASDITLEYKGKSVNL
                     KSIMGVMSLGVGQGADVTISAEGADADDAIAAISETMEKEGLA"
     gene            15832..17565
                     /gene="ptsP"
                     /locus_tag="VVR18_001324"
     CDS             15832..17565
                     /gene="ptsP"
                     /locus_tag="VVR18_001324"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HEU6032842.1"
                     /translation="MTEMLKGIAASDGVAVAKAYLLVQPDLSFETITVEDTNAEEARL
                     DAALQASQDELSVIREKAVGTLGEEAAQVFDAHLMVLADPEMISQIKETIRAKKVNAE
                     AGLKEVTDMFITIFEGMEDNPYMQERAADIRDVTKRVLANLLGKKLPNPASINEEVIV
                     IAHDLTPSDTAQLDKNFVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNNITEIVKDGD
                     ILAVNGITGEVIINPTDEQAAEFKAAGEAYAKQKAEWALLKDAQTVTADGKHFELAAN
                     IGTPKDVEGVNNNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVR
                     TMDIGGDKELPYFDMPHEMNPFLGFRALRISISETGDAMFRTQIRALLRASVHGQLRI
                     MFPMVALLKEFRAAKAVFDEEKANLLAEGVAVADNIQVGIMIEIPAAAMLADQFAKEV
                     DFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLINNVIKAAHAEGKWAGMCGE
                     MAGDQQAVPLLVGMGLDEFSMSATSVLRTRSLMKKLDTAKMEEYANRALTECSTMEEV
                     LELQKEYVNFD"
     gene            17820..20273
                     /gene="phtA"
                     /locus_tag="VVR18_001325"
     CDS             17820..20273
                     /gene="phtA"
                     /locus_tag="VVR18_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtA"
                     /protein_id="HEU6032843.1"
                     /translation="MKINKKYLVGSAAALILSVCSYELGLYQARTVKENNRVSYIDGK
                     QATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIFSEE
                     LLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHS
                     QHREGGTPRNDGAVALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN
                     ELSASELAAAEAFLSGRGNLSNSRTYRLQNSDNTPRTNWVPSVSNPGTTNTNTSNNSN
                     TNSQASQSNEDVDSLLKQLYALPLSQRHVESDGLVFDPAQITSRTARGVAVPHGDHYH
                     FIPYSQMSELEERIARIIPLRYRSNHWVPDSRPEQPSPQQTPEPSPGPQPAPNLKIDS
                     NSSLVSQLVRKVGEGYVFEEKGISRYVFAKDLPSETVKNLESKLSKQESVSHTLTAKK
                     ENVAPRDQEFYDKAYNLLTEAHKALFENKGRNSDFQALDKLLERLNDESTNKEKLVDD
                     LLAFLAPITHPERLGKPNSQIEYTEDEVRIAQLADKYTTSDGYIFDEHDIISDEGDAY
                     VTPHMGHSHWIGKDSLSDKEKVAAQAYTKEKGILPPSPDADVKANPTGDSAAAIYNRV
                     KGEKRIPLVRLPYMVEHTVEVKNGNLIIPHKDHYHNIKFAWFDDHTYKAPNGYTLEDL
                     FATIKYYVEHPDERPHSNDGWGNASEHVLGKKDHSEDPNKNFKADEEPVEETPAEPEV
                     PQVETEKVEAQLKEAEVLLAKVTDSSLKANATETLAGLRNNLTLQIMDNNSIMAEAEK
                     LLALLKGSNPSSVSKEKIN"
     gene            20431..>21357
                     /locus_tag="VVR18_001326"
     CDS             20431..>21357
                     /locus_tag="VVR18_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HEU6032844.1"
                     /translation="MKINKKYLAGSVATLVLSVCAYELGLHQAQTVKENNRVSYIDGK
                     QATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISEE
                     LLMKDPNYQLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNVRTKEEINRQKQEHS
                     QHREGGTSANDGAVALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN
                     ELSASELAAAEAFLSGRENLSNLRTYRRQNSDNTPRTNWVPSVSNPGTTNTNTSNNSN
                     TNSQASQSNDIDSLLKQLYKLPLSQRHVESDGL"
BASE COUNT         6830 a         3886 c         4388 g         6253 t
ORIGIN      
        1 agaacagaaa aaatgcttgg agtatttgtt tgtgtgttta tttttatata acaaactata
       61 aacaaaacaa aaatataaaa aaagagacaa aaaagaacag aaagtaattg acaacggttt
      121 catatagtgt tatacttatg gcataaagtt aatggaaaga agggaaaaac ttatggtatt
      181 agattatttc tttgacaaaa accttgtgtt ttgcttagaa gcggataatc aagaacaact
      241 ctttgatcag gttgcaactt tattggaaga acgagaaatt gtcactccaa cttatcgtga
      301 agccttgatc acgcgtgaaa agtcatttcc aactggttta gatatggaat ttctaggaaa
      361 ggacttgcca aatgtagcga ttcctcatac agatattgtt cataatctag ctgagaaagt
      421 ggtggttgtt cgattagaaa aaccagtaac ttttcacaat atgatagctc ctgataagga
      481 agtagaagta tccctactct tctttattat taacaattca agttcaagtc aaacaaatat
      541 tctggctcag ttgatggact ttttcacagg aaatggacat cttgaagatt tatcaaaaat
      601 ttccgaacca gaaaaacttt atgcttacat tgctgaagca accgcttaat cttgtctatt
      661 aaaaaataaa atcggaggaa atccaaatga ttaaaattct tgctgcctgc ggtgcaggtg
      721 ttaactcaag tcaccaaatt aaaagtgctc tagaagaaga actttcaaac cgtggttatg
      781 atgttcactg tgatgcagtc atggtgaaag atgtaaacga agaccttatg aaaggttacg
      841 atatctttac accaatcgct gcaacagacc ttggttttga accaggtatc ccagttatcg
      901 aagctgggcc aatcttattc tgtatcccag caatgagcgt tccagtattt gacaatatta
      961 gacttcctgc gaaacaaaat atggtatagt agttctatga atgatgaagc aagtaaacaa
     1021 ctaaccaatg cacaatttaa gcgtcttgtt ggtgttcagc gcacgacttt tgaagagatg
     1081 ttagctgtat taaaaacagc ttatcaactt aaacacgcaa aaggtggacg aaaacctaaa
     1141 ttaagtctag aagaccttct tatggccact cttcaatatg tgcgagaata ccgcacttat
     1201 gaagaaattg cggctgtttt tggtattcac gaaagcaact ttatccgtcg gagccaatgg
     1261 gttgaagtaa ctcttgttca aagtggtgtt acgatttcaa gaactcctct cagctctgag
     1321 gacacggtaa tgattgatgc gacggaagta aaaatcaatc gccctaaaaa aacaattagc
     1381 gaatcattct ggtaaaaaga aatgccacgc tatgaaggct cgagcgattg tcacaagtca
     1441 agggagaatt gtttctattg tcatgatatg aagttgttca aaatgagtcg cagaaatatc
     1501 ggacaagctg gtaaaatctt ggttgacagt ggttatcaag ggctcatgaa gatatatcct
     1561 caagtacaaa ctccacgtaa atccagcaaa ctcaagtcgc taatagctga agataaagcc
     1621 tataaccatg cgctatctaa ggaaagaagc aaggttgaga acatctttgc caaagtaaaa
     1681 acgtttaaaa tgttttcaac aacctatcga aatcatcgta aacgcttcgg attacgaatg
     1741 aatttgagtg ctggtattat caatcatgaa ctaggattct agttttgcag gaagtctaat
     1801 aaagaaacta gcaaggtcag gccttacttt attggtggac atccaggatt taattgtcct
     1861 ctacttgatg atgaagtcta tgaagattat tatctagagt ttgagaaaga agagatttgc
     1921 tctgttccac gtcctttccc agaaacaggt atgttggatt tccaagatag aagtccatgt
     1981 ctagagggac aaaaagaaat agatcttagt tatgatcttt tcagcacaga tgcagtgact
     2041 ttggatgaat tgcaatctcg aacaattgcc cttcgttctc ttaaacatga taagggattg
     2101 aaagtgcatt ttgcagaatt tccaaacctc atcatctggt caactttgaa caagggacct
     2161 ttcattacct ttgaaccatg gtctggcttg tcaacatccc ttgaagaagg agatcattta
     2221 gaagataaga agaatgtttg tctcttagaa gccaatcagg ttgaagaatt agggtttgag
     2281 atagaagttt tataaaaaag taaaaaataa ataacaaaaa caaacaaaag ctgttgactt
     2341 cttcaaacaa tagtagtata ttatgtttgt gaggactaat tgactgtttt ttaaagacag
     2401 tcaatacact gctggaatcc agcatagaaa aaataaaaag gagtatacaa tatgtctatt
     2461 gttatcggtg cagatgctgc aggtttgaga ttgaaagaag ttgtgaaaaa cttcttagaa
     2521 aaagaaaact tccaccttgt ggatgttaca gctgaaggtc aagactttgt tgatgtgact
     2581 ctcgctgttg ctgcagaagt aaacaaagaa gaacaaaacc ttggtatcgt gattgatgct
     2641 tatggagctg gtccatttat ggttgcaact aagatcaaag gaatggttgc tgcagaagta
     2701 tctgacgaac gttcagctta tatgactcgt ggccacaaca actcacgtat gatcactatg
     2761 ggtgcacaac ttgttggtga tgaattggct aaaaacatcg ctaaaggatt tgttaacggt
     2821 aaatacgatg gtggacgtca tcaaatccgg gtcgacatgt tgaacaaaat gggctaatta
     2881 gattacagta agaaaggtaa gttaaaaatg agaattgcaa ttggatgcga ccacatcgta
     2941 acagatgaaa aaatggcggt ttcagaattt ttgaaatcaa aaggatatga agtcattgac
     3001 tttggtacat atgaccatac acggactcac tacccaatct ttggtaaaaa agtaggggaa
     3061 gctgtaacta gcggccaagc tgatcttggg gtatgtatct gtggtactgg tgttggtatc
     3121 aacaacgctg taaataaagt tccaggtgtt cgttctgcct tggttcgtga tatgacaaca
     3181 gccctttatg ctaaagaaca attgaacgct aacgttatcg gctttggtgg taagattact
     3241 ggtgaattgc ttatgtgtga tatcatcgaa gctttcattc atgctgaata caaaccatct
     3301 gaagaaaaca agaaattgat tgcgaaaatt gaacaccttg aaagtcacaa tgctcaacaa
     3361 acagacgcaa acttctttac agaattcctt gaaaaatggg atcgcggaga ataccacgac
     3421 taagaggtga cctatgattt taacagtcac aatgaaccca tccattgata tttcctatcc
     3481 cttggatgag ttgaagattg atactgtcaa tcgtgtggtg gatgtaacca aaacggctgg
     3541 tggtaaggga ctcaatgtta cccgagtact ttcagaattt ggcgattctg ttcttgctac
     3601 tggtttagtg ggtggcaaac ttggtgagtt tttggttgaa catatcgata atcaagtaaa
     3661 gaaagatttc ttctcaattc agggagaaac tcgtaactgt atcgctattc tccacggaga
     3721 caaccaaaca gaagttcttg aaaaaggtcc tgaagtattg gaacaggaag gtcaagactt
     3781 tttggaacat ttcaaaaaac tcttggagtc agttgaagta gtagccatct caggtagtct
     3841 gccaactggc cttccagttg attactatgc gagcttggta gaacttgcta atcaagctgg
     3901 caagcctgta gtcttggact gctcaggtgc agcacttcag gctgttcttg aatcacccca
     3961 taaaccaaca gtcatcaaac caaataatga agaattgtct cagcttcttg gaagagaagt
     4021 ttctgaggat ttggatgaat taaaagaagt acttcaagaa cctttgtttg cagggattga
     4081 atggattatc gtttcacttg gtgccaacgg tacttttgcc aaacatggtg acactttcta
     4141 caaggtagat attcctagaa ttcaggtggt aaatcctgtt ggatctggag actctactgt
     4201 ggcaggaatt tcttcaggac ttcttcacaa agaatcggat gcagaattac tcatcaaggc
     4261 aaatgtcctt ggtatgctca atgctcaaga aaaaatgact ggtcatgtca acatggccaa
     4321 ctatcaagct ctatatgatc aattaatagt aaaagaggta taaaatggct ttaacagaac
     4381 aaaaacgtgt acgcttagaa aaactttctg atgaaaatgg tatcatctca gctcttgcat
     4441 ttgaccaacg tggtgctttg aaacgcctca tggctcaaca ccaaacagaa gaaccaactg
     4501 tggcccaaat ggaagaactt aaagtcttgg tagcagatga attgactaaa tacgcttcat
     4561 ctatgcttct tgaccctgag tatggacttc cagcaactaa agctcttgat gaaaaagctg
     4621 gtcttctcct tgcttatgaa aaaacaggtt atgacacaac aagcacaaaa cgcttgccag
     4681 actgcttgga tgtctggtct gcaaaacgta ttaaagaaga aggtgcagat gcagttaaat
     4741 tcttgcttta ctatgatgta gatagctcag acgaactcaa tcaagaaaaa caagcctaca
     4801 tcgaacgcat cggttctgag tgtgtggctg aagatatccc attcttcctt gaaatccttg
     4861 cttacgatga aaaaattgcg gatgcaggtt ctgtagaata cgcgaaagta aaaccacaca
     4921 aagttatcgg cgctatgaaa gtcttttcag acccacgctt taacattgat gtcttgaaag
     4981 ttgaagttcc tgttaacatt aaatatgttg aaggcttcgc tgaaggtgaa gtagtttata
     5041 cacgtgaaga agcagcagcc ttcttcaaag cgcaagatga agcaacgaac ttgccataca
     5101 tctacttgag tgctggtgta tcagctaaac tcttccaaga tactcttgta tttgctcatg
     5161 aatcaggtgc aaactttaac ggagttcttt gtggccgtgc tacatgggca ggatcagttg
     5221 aagcttacat caaagatggt gaagcagcag ctcgcgaatg gcttcgcaca actggatttg
     5281 aaaacattga tgagctcaat aaagttcttc aaacaacagc gacttcatgg aaagaacgtg
     5341 tgtaagaaag tcctcctagt ttaggaacat gaatctaaaa aaatttaaaa aaagttgtat
     5401 gtaaaggttt acaaaataac ttacttgtgc tatacttaaa tcacaagtta atacaaggtg
     5461 agtgttacta agtaatatta ggcatgatca caggtgaatt agaaatcagc tgattttcta
     5521 gttcatttgt ggtcattttt tgtactcata tacctttaag atataaaagg aggttgacat
     5581 gtatcgaatt ctaaatccaa tgaatcacaa tgtctcgctt gtcagaaatg ataagggaga
     5641 agaggtgatt gtaattggta aggggattgc attcggaaag aagaaggggg atttgattac
     5701 tgaaaatcag gttgagaaaa tctttcggat gaagaccgaa gagtccagag aaaactttat
     5761 ggctcttctc aaagatgttc cgcttgattt tatcacagtg acctatgaaa tcattgataa
     5821 gctatcaaag aaatatcatt atccgattca agagtatctc tatgtaacct tgacagatca
     5881 tatttactgt tcttatcaag ctctaactca aggaaggtac aaggatagta atctgccaga
     5941 tatttccgct aagtatcctg tcgcttttca aatcgcaaat gaagcttttg aaatttaccg
     6001 tcagaagcta gcagatcatt ttcctgagga cgaaattatt cggattgctt atcatttcat
     6061 taatgctgaa ggtgaaaatg aagtggaact tgtggagtcg attgataaga ggaaagaaat
     6121 tctcaggaat gttgaagaag ttttaacgga ctatgcaatt caacgaacta aaaagaataa
     6181 ccatttctat gatcgcttta tgatccattt gaattatttc ttggattatt tagacagatc
     6241 tagagatgat aaccaatcac ttctagatat ggaagatcat attaaacaat cctatccaaa
     6301 agccttcgag attggttcca agatctatga tgtgattacg caacatacgg gtcttgattt
     6361 gtataaaagt gaacgagttt atctagttct acatatccaa cgtttattgt cataaaaatt
     6421 tatttaaaac tatataagga gaattctatc atgaatagag aagaagtaac attgttaggt
     6481 tttgaaatcg tagcctatgc tggcgatgct cgttcaaaac tattggaagc cttgaaggct
     6541 gctgaagttg gtgattttga aaaagcggac gctctggtag aggaagctgg tagctgtatt
     6601 gcagaggctc accacgcgca aacaagtcta ttgactaagg aagcttctgg tgaggactta
     6661 gcgtatagtg tgaccatgat gcatggccaa gaccacttga tgacaactat cttgttaaag
     6721 gatttgatgc accatttgat cgaactttac aagagaggag ttaaataatg aacaaactaa
     6781 ttgcatttat cgagaaagga aagcctttct ttgagaaact atctcgtaat atctatcttc
     6841 gtgctattcg tgatggtttc attgcaggta tgcctgttat tctcttctca agtatcttta
     6901 tcttgattgc ctttgtacca aactcatggg gctttaaatg gtctgatgaa gttgtagcct
     6961 ttctgatgaa accttatagc tattctatgg gtattctggc tctcttggta gctggtacaa
     7021 cagctaagtc attgaccgac tcagtaaacc gtagcatgga gaaaaccaat caaatcaact
     7081 atatgtcaac gctgttagca gcgattgttg gtttgttgat gttggcagct gatcctatcg
     7141 aaaatggtct agctactgga ttcttgggga caaaaggttt gctttcagcc ttccttgctg
     7201 cctttgttac tgtagccatc tataaggttt gtgttaagaa caacgtcact attcgtatgc
     7261 ctgacgaagt tccaccaaat atctcacaag tctttaaaga tgtgattcca ttcactctat
     7321 ctgttgtttc tctttatgct cttgacttat tagcacgtca ttttgttggt tctagtgtgg
     7381 cagaatcaat cggtaaattc ttcgcaccac tcttctcagc agcagacgga taccttggta
     7441 ttaccattat ctttggtgcc tttgccttct tctggtttgt tgggattcat ggtccatcta
     7501 tcgttgaacc agctatcgca gctattacct atgccaatgc cgaagtcaac ttgaaccttc
     7561 tccaacaagg tatgcacgct gacaagattc ttacttctgg tacacaaatg tttatcgtta
     7621 ccatgggtgg tactggtgcg acactggttg ttccattcat gttcatgtgg ttaacaaaat
     7681 caaaacgtaa ccgtgcaatc ggacgtgctt cagtagttcc taccttcttc ggtgtaaatg
     7741 agccaatctt gtttggtgca cctcttgttt tgaatccaat cttcttcatt ccatttatct
     7801 ttgctccaat tgcaaacgta tggattttca aattctttat tgaaactctt ggaatgaact
     7861 cattcactgc taatctacca tggacaactc cagctccact aggtctagtt cttggaacta
     7921 acttccaagt gctatcattc attcttgctg cccttctaat cgtggttgac gttgtcattt
     7981 actatccatt ccttaaggtc tatgatgaac aaattcttga agaagaacgt tcaggtaagt
     8041 ctaatgatga attgaaagaa aaagttgctg caaacttcaa cactgcaaaa gcggatgcta
     8101 ttcttgaaaa agcgggtgtc gatgcagcac aaaataccat cactgaagaa acaaatgtcc
     8161 tcgttctctg tgctggtgga ggtacaagtg gactccttgc aaatgctttg aataaggcag
     8221 cagcagaata caatgtccct gtgaaagcag cagcaggcgg ctatggtgct caccgtgaaa
     8281 tgttgccaga gtttgatttg gttatccttg ctcctcaagt tgcttcaaac tttgaagata
     8341 tgaaggcaga aacagataag ctcggtatta aacttgctaa gacagaaggc gctcaataca
     8401 tcaaattaac tcgtgatgga aaaggtgccc tagcattcgt acaagagcaa ttcgattaag
     8461 gctaggaact gtgaaacagt ctcccatcgt tacggaaatc gctatggcga atttcctaat
     8521 cgccttatta attcttcggt aaaaagatat cgtttttacc tcctcatgtc acaattcagt
     8581 gacttggtac aagaagtgag atggagaagc atggctcact gactcctctc ctctcacttt
     8641 tactttattt aaatcaagaa ataggtgaaa aaaatgacaa aaacacttcc aaaagacttt
     8701 attttcggtg gcgcaacagc tgcttatcaa gcagaaggtg ctacacatac tgatggaaaa
     8761 ggaccagttg cttgggataa atatcttgag gataactact ggtacactgc cgaaccagct
     8821 agtgattttt acaatcgata tccagttgac ctcaagctag cagaagagta tggtgtcaat
     8881 ggtattcgaa tttctattgc ttggtcacgt attttcccga ctggttacgg ccaagtaaat
     8941 gctaaaggtg ttgagtttta tcataattta tttgcagagt gtcacaaacg tcatgttgag
     9001 ccttttgtaa ctcttcatca ctttgacacg ccagaagctc tccactcaaa tggagacttc
     9061 ttaaaccgtg aaaatatcga acattttgta gactacgctg ccttctgttt tgaagaattt
     9121 ccagaagtaa actattggac aacctttaat gaaattggac caatcggtga tggtcaatat
     9181 ttggttggga aattccctcc aggtatccag tacgaccttg ccaaagtctt tcaatcacac
     9241 cacaatatga tggtgtctca tgcacgcgcg gtaaaattgt acaaagagaa aggctataaa
     9301 ggagaaattg gtgttgttca cgccctgcct actaaatatc ctctagatcc tgaaaatcca
     9361 gcagatgttc gtgcagctga gttggaagat atcatccaca ataaattcat cttagacgca
     9421 acttatctag gtcgctattc agctgaaacc atggaaggtg tcaaccatat cttatcagtc
     9481 aatggtggta gtttggatct tcgtgaagaa gattttacag cattagaagc tgcaaaagac
     9541 ttgaatgatt tcctaggaat caactactat atgagtgact ggatggaagc ctttgatgga
     9601 gaaactgaaa ttatccataa tggtaaaggt gaaaaaggaa gctctaagta tcaaatcaaa
     9661 ggtgttggtc gtcgtgtagc tcctgactat gtaccacgca cggattggga ttggattatc
     9721 taccctcaag gtttgtatga ccaaatcatg cgtgtgaaga aagattatcc taactacaag
     9781 aagatttaca tcactgaaaa tggtctcggc tataaagatg agttcgttga taacactgtt
     9841 tacgatgatg gtcgtattga ttacgtgaaa caacacttgg agatcttgtc tgatgcgatt
     9901 gcagatggag ctaatgtaaa aggttacttc atttggtcat taatggatgt cttctcatgg
     9961 tcaaacggtt atgagaaacg ttatggtctc ttctacgtag attttgaaac tcaagaacgt
    10021 tatcctaaga aatcagctca ctggtacaag aaagtagcgg aaactcagat tatagactag
    10081 tagaattagt cattagatat agaattttag tgagtcaaaa agatgttcaa agattttatc
    10141 caatctattt atgaaaaaaa gtttatatta taaatttcga aaaatgctct caaataccgt
    10201 gtttgacgag tgaagaattg aaaagtcttg gaaaatggta tgtctcgact ggtaaagaat
    10261 ggatttgtca ttcagatgat gagctggaag aatttaaaaa tctattttta aattttatca
    10321 atcctgaaga atgggatact atctcctttg attcagattt tatgccgttt caacaatcgt
    10381 aaccaatttc tcaaaaaagt taaatcttat atttagtact ctgtaaaact cttatctaat
    10441 cacgttgctt atactcaatg aaaatcaaag agcaacttta aactaggaag cgagtcgcag
    10501 atttctcaat gcatagcttt gaggaattgg gcaaaaagtc tttgatatag aaaaaagcat
    10561 agtatcaggt gttgaaacac ctgatactat gctttttatt gtgggaagat ttactttttt
    10621 tcttctgaaa ttgagttgtt acccaggctc tttcagttta ttaaggcttg atgactttaa
    10681 tgtgtttaga tagcttaaaa aggattgaat cacttagttt agaatctgaa acaatagtat
    10741 caagatttga tatattataa aaagtataaa aatcaaactt attgaactta ctatgatctg
    10801 cgagtaaata ttttttatta gaattattta aagcgatgcg ttgagcctct ccctcttcct
    10861 cgctaaaagt agctagagct ccgttttgaa taccattaca gctaacgaaa gctttagaaa
    10921 attggagatt agagagattt tgtagggtca atgtgccaac aaaagcacct gtaatatcgc
    10981 gataatttcc acctattaaa atcaaatctg ttaattttcg ttcgcttaaa atcagaaaaa
    11041 caggtagact gttggttacg acgcggatat tgtcaatagg caactcacgc gcaaaaaact
    11101 ctaatgttgt tcctggtcca atgaaaatag tttctctttc ttctactaga ctgcctgcaa
    11161 aatgggctat ttcttgtttt tctgccgttt ggagggcttg tttttcaata tttgatcgct
    11221 catcagtcaa aagggagttg gttcgaagtt tttcagctcc accatgcaca cgaatcagca
    11281 aatctttatc agctaattcc tgtaaatagc gccttgcagt catatctgaa acggctattt
    11341 cgtccataat ctgtttaacc gttatggttc ctttgctatt tactatctct aaaattttgg
    11401 ttaatttttc ttgtttgagc atattatcac ctcgtttcct actactatct taccataaac
    11461 aaactcatca ttcaaataca aaaacaacaa aatgaaacaa aaacaaaaat atcgaagttt
    11521 gttttcaaaa ctttcgatat ttttgttggg ttataacttt gatgtttcta gtttactttt
    11581 tgatgattga gagtggtgga gaattagtct aaaccgtagt tatagtcatc gtcttgcatg
    11641 gcttcaactt cgccaagaag gtaaccattt ccgacttgag agaagaagtc gtggttggaa
    11701 gttcctgttg aaataccgtt cataacgatt gggttgacat cttcagctga atctgggaaa
    11761 agtggatctt gtcccatgtt catgagagct ttattggcat tgtagcgaag gaaggtttta
    11821 acctcttcag tccaaccaac accgtcataa agactctctg tgtagccttc ttcattttca
    11881 taaagagtat agagtaggtc gtacatccat tctttgagtt tttcttgctc ttcttcaggc
    11941 aattcattga aaccaagttg gaatttgtaa ccaatgtagg ttccgtgaac agactcgtca
    12001 cgaataatca atttaatgat ttctgcaacg ttggcaagtt tgttgttacc gagatagtag
    12061 aggggagtga agaaaccaga gtagaagagg aaggtttcga ggaagacgct ggcaactttc
    12121 ttttcaagtg ggctgccgtt taggtagatt tcgttgacaa tctcagcctt cttttgtagg
    12181 taaggattgg tattggtcca ttcgaaaatt tcttcaatct cagccttagt attcaaggta
    12241 gaaaagattg atgagtaaga tttagcgtgg acagattcca taaattggat gttattgaaa
    12301 acagcttcct catgtggtgt acggatgtct gcgcgaaggg cttgaacccc agtttcagat
    12361 tgcatagtgt caagaagggt taaaccacca aaaacttttc cgaccaagtc tttctctttg
    12421 ttagatagct ttctccagtc atccaagtcg tttgataagg gaatacgtgt atcgagccaa
    12481 aattgctccg tcagtttttc ccaagttgat ttgtcgatga catcttcgat ggcattccag
    12541 ttaatggctt tgtagtaagt ttccatttaa aatctctttc tgtgtttagt attgcgaact
    12601 cacaattatt tctactttac cataattcta taggagtatc gcacaaaaag tcggaagccc
    12661 gacttttaaa atgttacata aattatgtta tgacatagta gatttgattt tatcagtgct
    12721 gcttagggaa aaatagtgtt tctatgctag aaactaaatc acacagcttt cacattggtt
    12781 ggcgccgact tctccaccgt catctgtaaa ggtacggacg tagtagatag acttgattcc
    12841 cttgttaaag gcatagttac gaaggatgga caagtcacgt gtcgtttgtt tattttccct
    12901 cttccattcg taaaggcctt ttggaatgtc actacgcatg aagagggtga gtgaaagtcc
    12961 ttgatccacg tgttcagtcg cagcagcgta aacatcgatg actttacgca tatccatatc
    13021 gtaggcagaa gtgtagtaag gaatggtttc tgtagacaag ccagcagcag ggtagtagat
    13081 tttaccaatt ttcttttcct gacgttcttc aatacgttgc gtaatcgggt ggatagaagc
    13141 agaaacatcg ttgatgtagc tgatagaacc atttggcgct acagcaaggc gattttggtg
    13201 gtaaagacca tcttcttgaa ccttgtcgcg aagttcagcc caatcagcaa caccagggat
    13261 aaaaacattt ttgaagagtt ctttaacacg gtctgatgtt ggaacaaatt caccagttac
    13321 atacttgtca aagtaacttc cgttagcata gtctgatttt tcaaagttgt ggaaggtaat
    13381 accacgttca cgcgcaatat tgtttgactc taccaaggtc cagtagttca taagcataaa
    13441 gtagatgctt gtaaattcaa cagactcagg tgaaccatat tcaatgagtt gttgggcaag
    13501 gtagctgtgc agtcccatgg caccgagacc aaaggtgtgg gcttggctat ttccatggtc
    13561 aatcgttggt acagctacga tatgtgaact atctgtaacg aaagtaaggg cacgaaccat
    13621 agcacggata gaacgaccaa aatcaggtga agtcatcatg ttaaccacgt tggttgaacc
    13681 caggttacat gaaacatctg ttcccatttg aaggaattct tgagcatcgt tgatcaagct
    13741 tggttcttga acttgaagaa tctcagaaca caagttactc atgataatct ttccatcgac
    13801 aggatttgca cggttagccg tatcgatgtt gactacataa ggatagccag actcttgttg
    13861 caatttagag atttcagttt ccaaatcccg cgccttgatt tttgtcttgc gaatatttgg
    13921 atttgcgacc aattcatcgt atttttcagt aatgtcgatg taattgaatg gcacaccgta
    13981 ttctttttct acagagtaag ggctgaagag gtacatttct tcatttttac gagccaattc
    14041 gtagaattta tcaggtacta caacaccaag tgatagagtc ttgacacgta ctttttcatc
    14101 agcgttttct ttcttagttg aaaggaaagc gatgatatct gggtgaaaga cgttgaggta
    14161 gacaacaccg gcaccttgac gttgccccaa ttggttggag taagagaagc tgtcttcaaa
    14221 aagcttcata acaggaacga cacctgaagc agctccttca tagcctttga taggtgcacc
    14281 agcttcacga aggttgctga gggtaattcc cacaccacca ccaatacgtg aaagttgaag
    14341 agctgagttg atagaacgtc cgatagagtt catatcatcc gtcacttgga ttaggaaaca
    14401 agataccaac tccccacgac gagcacgtcc agcattcaag aaggaaggag tagcaggttg
    14461 gtagcgttgg tggatgattt cattggcaat atcgattgca acagcttcat tcccatcagc
    14521 gaaataaagg gcgttgaaga agacacggtc ttccatattt tcaagatagt attcaccgtc
    14581 attagtcttt aaggcatatt gattgtaaaa tttataagct gccatgaatg acttgaattg
    14641 gaagttttgg tctttgataa attgagccaa ttcttccaag aactctggac ggtatttctt
    14701 gataaaggct gtttcgatgt agttgtgttc aatgaggtaa ttgattttgt ctttgattga
    14761 atcaaaaacc atagtgtttg gaactacatt ttctttaaag aaagcatcca aggcttcctt
    14821 atctttatga agcatgattt gtccattaac aggacggtta atttcgttat taagacggaa
    14881 gtaagtcacg tcttcaagat gttttaatcc cataaaattt cccttatcta attacaaaag
    14941 aaaggcttct aagttagccc taaaagcagt ttcttctgga tgatgtacta agattatgct
    15001 aattgtttca gttttcctgg ttggaaacct gaaaagactt cagttggtgt ttggataaca
    15061 ggagctgcgc taaaaccgag ctctttaact tgatcgacgt actcaggttg ctcatcaaga
    15121 ttgatttcac gataagagac attattactg tccaagaaac gcttggtcat tttacattgg
    15181 acacaattgt ttttagaata aacggttacc attgtgtaac tcctcttcaa aatttaatac
    15241 tatcttagta tatcagaaaa taaaattttg tcaatgattt aaactaaata tagtggtgtt
    15301 cttttgttgt ttttatatat aaacacaata tatagtgttt gtattgtgaa atagcaatga
    15361 ttatcctata aattgttttt gaagaaacta tatcctgtgt tttgttatct aggatagaag
    15421 attttcagca agttatctga aaggaaattg aaggaaaatc cagaaaatgc ttgaaaaaaa
    15481 tcctagaaga tggtataata ctaaattgta agggttatca catataactc aaaaaaagaa
    15541 agaacaaaag gagagtcaaa ctatggcttc taaagatttc cacgtagtgg cagaaacagg
    15601 tattcacgca cgtccagcaa cattgttggt acaaactgct agcaaatttg cttcagatat
    15661 cactcttgag tacaaaggta aatcagttaa ccttaaatca attatgggtg ttatgagtct
    15721 tggtgttggt caaggtgctg acgtaactat ctcagctgaa ggtgcagatg cagatgacgc
    15781 tatcgctgca atctcagaaa caatggaaaa agaaggattg gcataaggga aatgacagaa
    15841 atgcttaaag gaatcgcagc atctgacggt gttgcagttg caaaagcata tctactcgtt
    15901 cagccggatt tgtcatttga gactattaca gtcgaagata caaacgcaga agaagctcgc
    15961 cttgatgccg ctctacaggc atcacaagac gagctttctg ttattcgcga gaaagcagta
    16021 ggtacgctcg gtgaagaagc agctcaagtt tttgatgctc acttaatggt tcttgctgac
    16081 ccagaaatga tcagccaaat caaggaaact atccgtgcga agaaagtgaa tgcagaagca
    16141 ggtctgaaag aagttacaga tatgtttatc actatctttg aaggcatgga agacaaccca
    16201 tacatgcaag aacgcgcagc ggatatccgc gacgtgacaa aacgtgtatt ggcaaacctt
    16261 cttggtaaaa aattgccaaa cccagcttct atcaatgaag aagtgattgt gattgcgcat
    16321 gacttgactc cttcagatac agctcaattg gacaaaaact ttgtaaaagc ttttgtaacc
    16381 aacatcggtg gacgtacaag ccactcagct atcatggcac gtacacttga aattgctgct
    16441 gtattaggta caaacaacat cactgaaatc gttaaagacg gtgacatcct tgctgttaac
    16501 gggatcactg gagaagtgat tatcaaccca acagatgaac aagcggcaga atttaaagca
    16561 gctggtgaag cctatgcgaa acaaaaagct gaatgggcac ttttgaaaga tgctcaaaca
    16621 gtgactgctg acggtaaaca cttcgagttg gctgccaata ttggtactcc aaaagacgtt
    16681 gaaggtgtta acaacaacgg tgcagaagct gttggacttt accgtacaga gttcttgtac
    16741 atggattctc aagacttccc aactgaagat gagcagtatg aagcatacaa ggctgttctt
    16801 gaaggaatga acggtaaacc tgttgtcgtt cgtacaatgg atatcggtgg agataaggaa
    16861 cttccttact tcgatatgcc tcacgaaatg aacccattcc ttggattccg tgctcttcgt
    16921 atctctatct ctgagactgg agatgctatg ttccgcacac aaatccgtgc tcttcttcgt
    16981 gcgtctgttc acggtcaatt gcgtatcatg ttcccaatgg ttgcgctctt gaaagaattc
    17041 cgtgcagcga aagcagtctt tgatgaagaa aaagcaaacc ttcttgctga aggtgttgca
    17101 gttgcggata acattcaagt tggtatcatg atcgagattc ctgcagcggc tatgcttgca
    17161 gaccaatttg ctaaagaagt tgacttcttc tcaattggta caaatgactt gatccaatat
    17221 acaatggcag cagaccgtat gaacgaacaa gtttcatacc tttaccaacc atacaaccca
    17281 tcaatcctac gcttgattaa caatgtgatc aaagcagctc acgctgaagg taaatgggct
    17341 ggtatgtgtg gtgagatggc tggtgaccaa caagctgttc cacttcttgt cggaatgggc
    17401 ttggatgagt tctctatgtc agcaacatct gtacttcgta cacgcagctt gatgaagaaa
    17461 ctcgacacag ctaagatgga agagtacgca aaccgtgccc ttacagaatg ctcaacaatg
    17521 gaagaagttc ttgaacttca aaaagaatac gttaattttg attaatcgaa aagtccctgc
    17581 aactcagtta cagggacttt ttttgatatt ttaaaaagaa ttttcaagaa aatctttctt
    17641 ataaaaagtc caaccttgaa aaagtagtgg tcagaacaaa aaatacttaa atggttcata
    17701 aaattcttga caagttggag atttaggagt aaactattaa ccagttaagt aatagagagg
    17761 agtttctgca atttagaaat gaattgcaac tagaaatatc aaatagaaag agagtttcga
    17821 tgaaaattaa taagaaatac cttgttggtt ctgcggcagc tttgatttta agtgtttgtt
    17881 cttacgagtt gggactgtat caagctagaa cggttaagga aaataatcgt gtttcctata
    17941 tagatggaaa acaagcgacg caaaaaacgg agaatttgac tcctgatgag gttagcaagc
    18001 gtgaaggaat caatgctgag caaatcgtca tcaagataac agaccaaggc tatgtcactt
    18061 cacatggcga ccactatcat tattacaatg gtaaggttcc ttatgatgcg attttcagtg
    18121 aagaattact catgaaagat ccaaactata agctaaaaga tgaggatatt gttaatgagg
    18181 tcaagggtgg atatgttatc aaggtagatg gaaaatacta tgtttacctt aaggatgctg
    18241 cccacgcgga taacgtccgt acaaaagagg aaatcaatcg acaaaaacaa gagcatagtc
    18301 aacatcgtga aggtgggact ccaagaaacg atggtgctgt tgccttggca cgttcgcaag
    18361 gacgctatac tacagatgat ggttatatct ttaatgcttc tgatatcata gaggatactg
    18421 gtgatgctta tatcgttcct catggagatc attaccatta cattcctaag aatgagttat
    18481 cagctagcga gttggctgct gcagaagcct tcctatctgg tcggggaaat ctgtcaaatt
    18541 caagaaccta tcgcctacaa aatagcgata acactccaag aacaaactgg gtaccttctg
    18601 taagcaatcc aggaactaca aatactaaca caagcaacaa cagcaacact aacagtcaag
    18661 caagtcaaag taatgaggat gttgatagcc ttctgaaaca actttatgcc ttgccactca
    18721 gccaacgaca cgtagaatct gatggccttg tctttgatcc agcacaaatc acaagtcgaa
    18781 cagctagagg tgttgcagtg ccacacggag atcattacca cttcatccct tactctcaaa
    18841 tgtctgaatt ggaagaacga atcgctcgta ttattcccct tcgttatcgt tcaaaccatt
    18901 gggtaccgga ttcaaggccg gaacaaccaa gtccacaaca gactccggaa cctagtccag
    18961 gcccgcaacc tgcaccaaat cttaaaatag actcaaattc ttctttggtt agtcagctgg
    19021 tacgaaaagt tggggaagga tatgtattcg aagaaaaggg catctctcgt tatgtttttg
    19081 cgaaagattt accatctgaa actgttaaaa atcttgaaag caagttatca aaacaagaga
    19141 gtgtttcaca cactttaact gctaaaaaag aaaatgttgc tcctcgtgac caagaatttt
    19201 atgataaagc atataatctg ttaactgagg ctcataaagc cttgtttgaa aataagggtc
    19261 gtaattctga tttccaagcc ttagacaaat tattagaacg cttgaatgat gaatcgacta
    19321 ataaagaaaa attggtagat gatttattgg cattcctagc accaattacc catccagagc
    19381 gacttggcaa gccaaattct caaattgagt atactgaaga cgaagttcgt attgctcaat
    19441 tagctgataa gtatacaacg tcagatggtt acatttttga tgaacatgat ataatcagtg
    19501 atgaaggaga tgcatatgta acgcctcata tgggccatag tcactggatt ggaaaagaca
    19561 gcctttctga taaggaaaaa gttgcagctc aagcctatac taaagaaaaa ggtatcctac
    19621 ctccatctcc agacgcagat gttaaagcaa atccaactgg agatagtgca gcagctattt
    19681 acaatcgtgt gaaaggggaa aaacgaattc cactcgttcg acttccatat atggttgagc
    19741 atacagttga ggttaaaaac ggtaatttga ttattcctca taaggatcat taccataata
    19801 ttaaatttgc ttggtttgat gatcacacat acaaagctcc aaatggctat accttggaag
    19861 atttgtttgc gacgattaag tactacgtag aacaccctga cgaacgtcca cattctaatg
    19921 atggatgggg caatgccagt gagcatgtgt taggcaagaa agaccacagt gaagatccaa
    19981 ataagaactt caaagcggat gaagagccag tagaggaaac acctgctgag ccagaagtcc
    20041 ctcaagtaga gactgaaaaa gtagaagccc aactcaaaga agcagaagtt ttgcttgcga
    20101 aagtaacgga ttctagtctg aaagccaatg caacagaaac tctagctggt ttacgaaata
    20161 atttgactct tcaaattatg gataacaata gtatcatggc agaagcagaa aaattacttg
    20221 cgttgttaaa aggaagtaat ccttcatctg taagtaagga aaaaataaac taatgaaaaa
    20281 tgaaagtctc gataaagagg ctttcatttt tattatgtat atatgtaaaa ttcttgacaa
    20341 gcaatattaa aaagagtaaa ctattaacta gttaattaac cggtttatta ctttatagtg
    20401 aatcaaatat acttaagaaa agaggaaaga atgaaaatca ataaaaaata tctagctggg
    20461 tcagtagcta cacttgtttt aagtgtctgt gcttatgaac taggtttgca tcaagctcaa
    20521 actgtaaaag aaaataatcg tgtttcctat atagatggaa aacaagcgac gcaaaaaacg
    20581 gagaatttga ctcctgatga ggttagcaag cgtgaaggaa tcaacgccga acaaatcgtc
    20641 atcaagatta cggatcaagg ttatgtgacc tctcatggag accattatca ttactataat
    20701 ggcaaggtcc cttatgatgc catcatcagt gaagagctcc tcatgaaaga tccgaattat
    20761 cagttgaagg attcagacat tgtcaatgaa atcaagggtg gttatgtcat taaggtaaac
    20821 ggtaaatact atgtttacct taaggatgca gctcatgcgg ataatgtccg tacaaaagaa
    20881 gaaatcaatc ggcaaaaaca agaacatagt cagcatcgtg aaggagggac ttcagcaaac
    20941 gatggtgcgg tagccttggc acgttcacag ggacgctaca ccacagatga tggttatatc
    21001 ttcaatgcat ctgatatcat cgaagatacg ggcgatgcct atatcgttcc tcatggagat
    21061 cattaccatt acattcctaa gaatgagtta tcagctagcg agttggctgc tgcagaagcc
    21121 ttcctatctg gtcgggaaaa tctgtcaaat ttaagaacct atcgccgaca aaatagcgat
    21181 aacactccaa gaacaaactg ggtaccttct gtaagcaatc caggaactac aaatactaac
    21241 acaagcaaca acagcaacac taacagtcaa gcaagtcaaa gtaatgacat tgatagtctc
    21301 ttgaaacagc tctacaaact gcctttgagt caacgacatg tagaatctga tggcctt
//
LOCUS       DAVHSO010000035        21172 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.035, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000035 DAVHSO010000000
VERSION     DAVHSO010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21172)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21172)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21172
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.035"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            130..606
                     /locus_tag="VVR18_001327"
     CDS             130..606
                     /locus_tag="VVR18_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032845.1"
                     /translation="MKLSLYSEVEHYHFLSSYSLNDITYTDTPKNIIEKSKKDKYRYP
                     IVILNKDHKVIGFFCLHLNTGPKEYGYYQNDYALIRGFSIHDNFRNQGYGSNALNEIF
                     EFIDSTLKLEINHIILAVNEKNILAQKAYRNSGFSVVKKDLEGKRGKLIIMEKSRN"
     gene            complement(1261..1674)
                     /locus_tag="VVR18_001328"
     CDS             complement(1261..1674)
                     /locus_tag="VVR18_001328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEU6032846.1"
                     /translation="MWKKKKVKAGVLLYAVTIAAIFSLLLQFYLNRQIAHYQDYALNK
                     EKLVAFAMAKRTKDKAEQESGEQVFNLGQVSYQNKKTSLVTTVRTDKSQYEFLFPSVK
                     IKEEKRDKKEEVATDSSEKAEKKKSEEKPEKKENS"
     gene            complement(1652..2113)
                     /locus_tag="VVR18_001329"
     CDS             complement(1652..2113)
                     /locus_tag="VVR18_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000250539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEU6032847.1"
                     /translation="MVQNSCWQSKSHKVKAFTLLESLIALIVISGGLLLFQAMSQLLI
                     SEVRYQQQSEQKEWLLFVDQLEAELDRSQFEKVEGNRLYMKQDGKEIAMGKSKADDFR
                     KTNARGRGYQPMVYGLKSAQITEDNQLVHFRFQFQKGLEREFIYRVEKEES"
     gene            complement(2076..2336)
                     /locus_tag="VVR18_001330"
     CDS             complement(2076..2336)
                     /locus_tag="VVR18_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032848.1"
                     /translation="MILLEAVVALAIFASIATLLLGQIQKNRQEEAKILQKEEVLRVA
                     KMALQTGQNQVSINGVEIQVFSSEKGLEVYHGSEQLLAIKEP"
     gene            complement(2341..2820)
                     /locus_tag="VVR18_001331"
     CDS             complement(2341..2820)
                     /locus_tag="VVR18_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HEU6032849.1"
                     /translation="MDASRKNRLKPIKNTMINKILVKSLKIKAFTMLESLLVLGLVSI
                     LALGLSGSVQSTFAAVEEQIFFMEFEELYRETQKRSVASQQKTSLNLDGQMISNGSQK
                     LPVPKGIQAPSGQSITFDRAGGNSSLAKVEFQTSKGAIRYQLYLGNGKIKRIKETKN"
     gene            complement(2738..3061)
                     /gene="comGC"
                     /locus_tag="VVR18_001332"
     CDS             complement(2738..3061)
                     /gene="comGC"
                     /locus_tag="VVR18_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="comG operon protein ComGC"
                     /protein_id="HEU6032850.1"
                     /translation="MKKMMTFLKKAKVKAFTLVEMLVVLLIISVLFLLFVPNLTKQKE
                     AVNDKGKAAVVKVVESQAELYSLEKNEDASLRKLQDDGRITEEQAKAYKEYHDKQNTS
                     QIVKD"
     gene            complement(3063..4079)
                     /locus_tag="VVR18_001333"
     CDS             complement(3063..4079)
                     /locus_tag="VVR18_001333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000355375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HEU6032851.1"
                     /translation="MDISQVFRLRRKKLATAKQKNIITLFNNFFSSGFHLVETISFLD
                     RSALLDKQCVTRMRVGLSQGKSFSEMMESLGCSSAIVTQLSLAEVHGNLHLSLGKIEE
                     YLDNLAKVKKKLIEVATYPLILLFFLLLIMLGLRNYLLPQLDSSNIATRIIGNLPQIF
                     LGMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQ
                     GMELTQIFQMMQEQGSQLFKEIGQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGE
                     VKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIVLLYAAMLMPMYQNM
                     EVNF"
     gene            complement(4027..4968)
                     /locus_tag="VVR18_001334"
     CDS             complement(4027..4968)
                     /locus_tag="VVR18_001334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000249584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HEU6032852.1"
                     /translation="MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIG
                     SYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESL
                     VIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
                     VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVV
                     RASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFAN
                     RDYQEHQAVKWNEQIDQLLKDGHITSLQAETEKISYS"
     gene            complement(5044..5409)
                     /locus_tag="VVR18_001335"
     CDS             complement(5044..5409)
                     /locus_tag="VVR18_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1033 family protein"
                     /protein_id="HEU6032853.1"
                     /translation="MYRVIEMYGDFEPWWFLEGWEEDIVASRKFDQYYDALKYYKTCW
                     FRLEQESPLYKSRSDLMTIFWDPEDQRWCDECDEYLQQYHSLALLQDEQVIPDEKLRS
                     GYEKQTSQERNRSCRMKLK"
     gene            complement(5560..6618)
                     /locus_tag="VVR18_001336"
     CDS             complement(5560..6618)
                     /locus_tag="VVR18_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="HEU6032854.1"
                     /translation="MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHI
                     IKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYA
                     HCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
                     LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLDTALSFGATHKVN
                     SSDPEKAIKEIYDLTDGRGVDVAIEAVGIPETFDFCQKIIGVDGTVANCGVHGKPVEF
                     DLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSK
                     AADHHAIKVIIENDISEA"
     gene            complement(6781..7932)
                     /gene="nagA"
                     /locus_tag="VVR18_001337"
     CDS             complement(6781..7932)
                     /gene="nagA"
                     /locus_tag="VVR18_001337"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HEU6032855.1"
                     /translation="MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVID
                     YTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQ
                     LLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
                     NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYN
                     GMRGLTHRELGMVGAMYQLPHTYAELICDGHHVDPKACEILIKQKGTENIALITDCMT
                     AGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVM
                     MASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA"
     gene            complement(8085..9902)
                     /locus_tag="VVR18_001338"
     CDS             complement(8085..9902)
                     /locus_tag="VVR18_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyltransferase"
                     /protein_id="HEU6032856.1"
                     /translation="MRIKWFSLVRITGLLLVLLYHFFQTIFPGGFFGVDVFFTFSGFL
                     ITALLIEEFSKNNEIDLIGFFRRRFYRIVPPVVLMVLVTMPFTFLVRQDYVAGIGGQI
                     AGVLGFMTNFYELLTGGSYESQFIPHLFVHNWSLAVEVHYYILWGLAVWFLSKQAKSN
                     GQLKGMVFLLSAAAFLISFFSMFIGSFLVTSYSSVYFSSLTHVYPFFLGSMLATIVGV
                     RQTTSLVKQLDKIWDLRKTLVVFGGGFGFLVLLTFFVKFTYLFAYLIGFLLASLAALA
                     MILAARVLHEKTHHIQEPKIISFLADTSYAVYLFHWPFYIIFSQLTSNLLAVLLTLIC
                     SYGFASLSFYVLEPWIAGKNTPILQTLRPLPYIHAILAAGTGILTFIVCMVTLLAPQV
                     GAFETDLTVNGLKQAATNIGQTKVMAERADANSLGIADGTMLIGDSVALRANTALQTA
                     LPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDWDSIVKNLP
                     KGHRMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITIADWNQVAKEHPEIWAG
                     TDQVHFGSESSTIEAGAKLYADTIATALQTAQDKPVKSK"
     gene            complement(10003..11145)
                     /gene="tgt"
                     /locus_tag="VVR18_001339"
     CDS             complement(10003..11145)
                     /gene="tgt"
                     /locus_tag="VVR18_001339"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004298827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HEU6032857.1"
                     /translation="MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQAT
                     VKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQV
                     YSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYD
                     YVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSI
                     GGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTR
                     IARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIR
                     LTSYHNLYFLLNLMKQVRQAIMDDNLLEFRKYFVEKYGYNKSGRNF"
     gene            11275..12132
                     /locus_tag="VVR18_001340"
     CDS             11275..12132
                     /locus_tag="VVR18_001340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HEU6032858.1"
                     /translation="MNYPKIDLKTIRQESKHFQADTPRLFLLYILPSMLVILSGFLNP
                     LSRIHGTVLEQPFFSILGQILQAYLFPLLVSFIGTILLTSSVYATLTLMKDSKTEPSV
                     KNSLALFDEERFSQTFLTLLLKRFYLFLWSIPNLLGIYLLFYSSFLAKKFVTLHPEFP
                     NLDLSSVETERFLMVFGLYFLASLILIIVGNILYIPQYYAYSQVEFLLCYSLDLGQVP
                     PRRILKTSRSFMKGYKFQRFVLDLQLLPWYFLNWITFGIASFSLLPYIQCTKIMFYRA
                     VLARKRPKA"
     gene            complement(12160..12803)
                     /gene="pcp"
                     /locus_tag="VVR18_001341"
                     /pseudo
     CDS             complement(12160..12803)
                     /gene="pcp"
                     /locus_tag="VVR18_001341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
     gene            complement(12910..13269)
                     /locus_tag="VVR18_001342"
     CDS             complement(12910..13269)
                     /locus_tag="VVR18_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1304 domain-containing protein"
                     /protein_id="HEU6032859.1"
                     /translation="MSIILTTIVALEHFYIFYLESIATQSDATSRVFNMEKEELAHPS
                     VSLLLKNQGIYKALLGVFLLYGIYFSQNLEIVTIFVLFVIGAATYGSLTADKKIILKQ
                     GGSAILALISILLFKYT"
     gene            complement(13280..13705)
                     /locus_tag="VVR18_001343"
     CDS             complement(13280..13705)
                     /locus_tag="VVR18_001343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HEU6032860.1"
                     /translation="MLEIQDLLYQLRLSEQASTQLFEKRLGISLTRYQILLFLLEHSP
                     CNQMAVQERLKIDQAALTRHFKILETEGLVERHRNPENQREVLVEAAKYAKEQLVVNP
                     PLQHIRVKEEIESILTEFERTELSRLLNKLVLGIENIEI"
     gene            complement(14028..15140)
                     /locus_tag="VVR18_001344"
     CDS             complement(14028..15140)
                     /locus_tag="VVR18_001344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEU6032861.1"
                     /translation="MKKRMLLASTVALSFAPVLATQAEEVLWTARSVEQIQNDLTKTD
                     NKTSYTVQYGDTLSTIAEALGVDVTVLANLNKITNMDLIFPETVLTTTVNEAEEVTEV
                     EIQTPQADSSEEVTTATADLTTNQVTVDDQTVQVADLSQPIAEVTKTVIASEEVAPST
                     GTSVPEEQTTETTRPVEEATPQETTPAEKQETQASPQAASAVEVTTTSSEAKEVASSN
                     GATAAVSTYQPEETKIISTTYEAPAAPDYAGLAVAKSENAGLQPQTAAFKEEIANLFG
                     ITSFSGYRPGDSGDHGKGLAIDFMVPERSELGDKIAEYAIQNMASRGISYIIWKQRFY
                     APFDSKYGPANTWNPMPDRGSVTENHYDHVHVSMNG"
     gene            complement(15306..15939)
                     /locus_tag="VVR18_001345"
                     /pseudo
     CDS             complement(15306..15939)
                     /locus_tag="VVR18_001345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001172828.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
     gene            complement(15943..17223)
                     /locus_tag="VVR18_001346"
     CDS             complement(15943..17223)
                     /locus_tag="VVR18_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEU6032862.1"
                     /translation="MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGV
                     SVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFL
                     SIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
                     SFLSNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDK
                     ELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATA
                     TVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVE
                     ASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVL
                     GWGLPGIWAGSLLDNGFRWLFLRYRYQRYMSLKG"
     gene            complement(17284..18768)
                     /locus_tag="VVR18_001347"
     CDS             complement(17284..18768)
                     /locus_tag="VVR18_001347"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HEU6032863.1"
                     /translation="MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLNF
                     DKLKDASYQEVAKLVLSAFLDDFTVEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLE
                     LFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFANVPGT
                     EIIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTT
                     NKLQFSSANSMNIGRLVPQIVYYVYAYAQLVKTGEIVAGEKVNFTVPTGNFGNILAAF
                     YAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSMDILVSSNLERLIF
                     HLLGNNAEKTTELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDS
                     YIEDPHTAVASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEAL
                     AQLHEISGVAVPPAVDGLEIAPIRHKTTVAAADMQAAVEAYLGL"
     gene            complement(18844..20121)
                     /locus_tag="VVR18_001348"
     CDS             complement(18844..20121)
                     /locus_tag="VVR18_001348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamylcysteine synthetase"
                     /protein_id="HEU6032864.1"
                     /translation="MSCSIDLLKHRYLKNIKENPELFVGIELEYPVASLEGDATDVEV
                     MKDLFHYLVSTLDLTVAKVDDFGNLIQLVDPISQDAILFEVSYTTIEFAFGKAETIQE
                     VENRFNNYMNVIQRKLAESNHAIVGCGIHPNWDKNENCPVAYPRYQMLMDYLNLSRNI
                     IKSDLHHFPEYGTFICGSQVQLDISKTNYLRVINAFTQIEAAKAYLFANSEFSGADWD
                     TKISRDIFWEESMHGIYPENVGVNARLLNDEADFFDYLNHSAIFTAERDGQTYYFYPI
                     QAGDYLATSEIQAFALNGDEVIIYPQEKDFETHRSYQYQDLTTRGTVEFRSVCTQPLD
                     RTFASAAFHLGLLVNLDKLEAYLETAPFFKVFGYDYKSLRRQFSKKNLTDEEETTIIE
                     FSKDLLLLAEEGLVVRNKEEMTYLQPLREELSL"
     gene            complement(20228..20311)
                     /locus_tag="VVR18_001349"
     tRNA            complement(20228..20311)
                     /locus_tag="VVR18_001349"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20275..20277),aa:Leu,seq:caa)
     gene            complement(20321..20392)
                     /locus_tag="VVR18_001350"
     tRNA            complement(20321..20392)
                     /locus_tag="VVR18_001350"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20358..20360),aa:Gln,seq:ttg)
     gene            complement(20403..20475)
                     /locus_tag="VVR18_001351"
     tRNA            complement(20403..20475)
                     /locus_tag="VVR18_001351"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20440..20442),aa:His,seq:gtg)
     gene            complement(20490..20560)
                     /locus_tag="VVR18_001352"
     tRNA            complement(20490..20560)
                     /locus_tag="VVR18_001352"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20526..20528),aa:Trp,seq:cca)
     gene            complement(20565..20645)
                     /locus_tag="VVR18_001353"
     tRNA            complement(20565..20645)
                     /locus_tag="VVR18_001353"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20609..20611),aa:Tyr,seq:gta)
     gene            complement(20658..20730)
                     /locus_tag="VVR18_001354"
     tRNA            complement(20658..20730)
                     /locus_tag="VVR18_001354"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20695..20697),aa:Phe,seq:gaa)
     gene            complement(20734..20807)
                     /locus_tag="VVR18_001355"
     tRNA            complement(20734..20807)
                     /locus_tag="VVR18_001355"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20771..20773),aa:Met,seq:cat)
     gene            complement(20818..20907)
                     /locus_tag="VVR18_001356"
     tRNA            complement(20818..20907)
                     /locus_tag="VVR18_001356"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(20869..20871),aa:Ser,seq:tga)
     gene            complement(20990..21063)
                     /locus_tag="VVR18_001357"
     tRNA            complement(20990..21063)
                     /locus_tag="VVR18_001357"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(21027..21029),aa:Ile,seq:gat)
     gene            complement(21098..21168)
                     /locus_tag="VVR18_001358"
     tRNA            complement(21098..21168)
                     /locus_tag="VVR18_001358"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(21134..21136),aa:Gly,seq:tcc)
BASE COUNT         6324 a         4843 c         3746 g         6259 t
ORIGIN      
        1 gaaaataaag gactaaagca ataactctaa atacatctga tttttatagg atatttcata
       61 aaaaaaatct acatacctag agtcctattt agttatgtat cttacataaa gagaaaggaa
      121 ttaattatca tgaaattatc tttgtatagt gaagttgaac attaccattt tttaagttct
      181 tattctttaa atgatattac atatactgat accccaaaaa atattattga aaagtctaaa
      241 aaagataagt atagataccc aatagtaata cttaataaag accataaagt aattggattt
      301 ttttgcctac acctaaacac tggtcctaaa gagtatggct attatcaaaa tgattatgcg
      361 cttattagag gattttctat tcatgataat ttcagaaatc aaggatatgg ttctaatgct
      421 ctgaatgaaa tatttgaatt catagactca actttaaaat tagaaattaa ccatattata
      481 ttggctgtaa atgaaaaaaa tatattggct caaaaagcat atagaaattc cggtttttct
      541 gttgtgaaaa aagatttaga aggaaaaagg gggaaattaa ttattatgga gaaaagcaga
      601 aactagtaat gatactagtt tctgcttttc tctaagtctg ctataaattt ataacatgtt
      661 gaaataagat gtgaataaat tgattgcaga attcaaacca atttctaaca atgttttaga
      721 aaactcggcg gactattcca gattcaatcc actatattct atcttatttg catattttga
      781 gagaaataat ctatatacta aacttttatg tttataattc attcctttcg tttcactcaa
      841 ggcacaagac agaatgaaaa agtggtgtgc tctttatttt gttttataat aatagtgaga
      901 aaacctatca ctactacaaa tcacggggag gtgaataagt gagtggtata gccactacct
      961 cgcattttta taggtgtcat tctttccatc aagcacaaga actgtgacta ggagcacgta
     1021 aacttataat tgaataagcg actcgtttgt gaaaggaaag aatagtcaag ggataggcag
     1081 actcaaattt ggtgaaggga aacccctcat gttaaaagcc aaacttcaat tttaaaaatt
     1141 ttaaaatttg tttcgtattc actactcctt gcctttatat tggattgatt aagagaacct
     1201 ttcgcgtttc tagaaactac agtggactat tctggattca acacattata gttgaattga
     1261 ctaggaattc tctttctttt caggcttctc ttctgatttt ttcttctccg ctttttcgct
     1321 tgaatcagtc gctacctctt cctttttatc tcttttctct tctttgattt tgactgaagg
     1381 aaacagaaac tcatattgac tcttatccgt acgaacagtc gtcaccaagc ttgttttctt
     1441 gttttgatag cttacctgac ctagattaaa gacctgttcc ccactttctt gctcggcttt
     1501 atccttggtt cgcttggcca tggcaaaagc aaccaacttt tctttattta aagcatagtc
     1561 ttgatagtgg gcgatttgtc ggttcaagta aaattgtaac aaaagactaa agatggctgc
     1621 tatggtgact gcgtagagga gaacacctgc cttaactttc ttctttttcc acacgataga
     1681 tgaactccct ttctaagcct ttttgaaact ggaaacgaaa atgaaccagt tgattgtcct
     1741 ctgtaatctg agctgatttg aggccataaa ccataggctg ataacctcga ccacgagcat
     1801 tcgttttacg gaaatcatct gccttagact tacccatagc aatctccttg ccatcttgct
     1861 tcatgtatag gcgattgcct tctacttttt cgaactgcga acggtctaat tctgcctcaa
     1921 gttggtccac aaacaagagc cactcctttt gctcgctttg ttgctggtag cgaacttctg
     1981 aaatgaggag ctgactcata gcttgaaaaa ggagtaatcc cccactgatg acaatcaggg
     2041 caatcaggga ttctaacaag gtaaaagcct tgaccttatg gctctttgat tgccaacaac
     2101 tgttctgaac catggtagac ctccaatcct ttttcactag aaaatacctg aatctcaact
     2161 ccgttgatgc ttacctgatt ttgccccgtc tgcaaggcca tcttagctac cctcaagact
     2221 tcttcctttt gcaagatttt tgcttcctct tgcctatttt tttgaatttg tcccaaaagg
     2281 agggtcgcaa tgctggcaaa gatagctaga gcgactactg cttccagtaa aatcactgcc
     2341 ctaatttttt gtttccttaa tgcgtttaat ttttccattt cctagatata attgatagcg
     2401 aatcgctcct ttactggtct gaaattcaac cttagccagg gacgaattgc ccccagcacg
     2461 gtcaaatgta atactttggc ctgatggggc ctgaattcct ttagggactg gcaacttttg
     2521 actgccattg ctaatcatct gcccatccaa gttcagacta gtcttttgtt gactagctac
     2581 actgcgtttt tgggtttccc gatagagttc ttcaaactcc ataaagaaaa tctgttcctc
     2641 taccgctgca aaagtggact ggacagagcc ggacaagccc aaggcaagga tactcacaag
     2701 tcccaaaacc aagagacttt ccagcatggt aaaggcctta atctttaacg atttgactag
     2761 tattttgttt atcatggtat tctttatagg ctttagcctg ttcttccgtg atgcgtccat
     2821 cgtcttgtaa ctttcttagg ctagcatctt cattcttttc caagctataa agttctgcct
     2881 ggctttccac caccttaaca acagctgctt ttcctttgtc attgactgct tctttttgct
     2941 tggtcagatt aggtacaaag agcaagaaaa gcacgctgat aatcagcaag accaccaaca
     3001 tttccaccaa tgtaaaagct ttaaccttag cttttttcaa gaatgtcatc atttttttca
     3061 ttttaaaaat ttacctccat attttgatac atgggcatga gcattgccgc ataaagtaaa
     3121 acgataatca gtgccacaaa aataaaaacc agtggctgca ccaaattcat ggtgcggttg
     3181 actcgggtaa aaaaggcttc ccaagttttt tcagcataga tttccaactc actacccagc
     3241 ttggacttaa cttccccata ctctatgatg agactcaatt ccttcctaaa gaaaggatag
     3301 gttcctatcg tctgagaaaa ttcacggcca tttttcaggg tttgagccag atcttgaccg
     3361 atttctttaa agagctggga accttgttcc tgcatcattt gaaaaatctg cgtcagctcc
     3421 attccctgtg aaatcatatt cccccattca cgtgcataat aggctgtcaa gtaggtctgc
     3481 acaaatattc caataaaggg aaggcgtgct aagatagaaa agacactcat cttagaactt
     3541 cttttataaa aagttagtgc taaaagggca agcacggaaa caagccctac catgcctaga
     3601 aaaatttgtg gcagattacc gataattcgg gtggcaatat tgctactatc cagttgtggg
     3661 agcaggtaat tccgtagccc cagcatgatt aagagaagaa aaaacagcaa aatcaaggga
     3721 taggtcgcta cttcaatcaa ttttttcttg accttggcca gattgtccag atattcttct
     3781 atctttccca aactcaggtg gagattgcca tgaacttcag ctagggataa ctgagtgaca
     3841 atagcacttg aacatcccaa actttccatc atttctgaga atgatttccc ctgagacaag
     3901 cccacacgca tccgggtcac acactgcttg tccaacaaag cactcctatc taaaaaggag
     3961 atggtctcca ccagatgaaa accgctagaa aagaaattgt taaatagggt gatgatattt
     4021 ttttgcttag ctgtagctaa ttttttccgt ctcagcctga agacttgtga tatgtccatc
     4081 tttaagaagc tggtcaattt gctcattcca cttgactgct tggtgttctt gataatctct
     4141 gtttgcaaag tcaacgattc ctcctccccc gattaatctc tggtagcaga ctccttgcag
     4201 aacaactgcc aattcttctt cactcacacc caactccagc agacgctcat aaacacctcg
     4261 gatactcttg gcgtgaatgg ttgaaaagac tgtcgcacct gtcaaactag ctctgaccac
     4321 tgcacgcgcc gtctcgctgt cacgaatttc tccgataatc aagagatctg gtcgatgacg
     4381 caaggaaagt ttgattagat tttcataggt taggccgatt gcttcgttca actgcaactg
     4441 aagcatgtcg tcctgcttga tttcgacagg atcttcgatg gacataactt gctgtccttt
     4501 aaagagtgac ttggacaatt catgcatcaa ggtcgtctta ccactcccaa ccggaccagc
     4561 aaaaagatag agtccccgtt gcctgtactg cttgcctaat tcttcaatat cctgaaacca
     4621 aaaatgcaag tcctgctcct catcgtgcaa caaacggata accaaactct catgcccccg
     4681 ataatcgcct acagtagata aacgtagaga cgccatcttc tggtcatagg cataatcaca
     4741 ggaacccagt tgactacgtc ttttttctcc cacattcata cccgccacaa acttaaagtg
     4801 actgataacg gctgcaaact tttcaaaatc atagctacca attttacagc gctcgtctcc
     4861 taccctcata tgaagctcat aggcatctaa cttagggaca aaataaatat cctgcgtccc
     4921 ttttttccga gctgaacgaa tgatttcttg tgcaatttct tgaaccatac ttacctcctc
     4981 acctatacta ttcgcaaaga gttagaaaaa taaaaaaagc aactccaaaa aagttacttt
     5041 tctctatttt aatttcatac ggcaagaacg attcctttcc tgactggttt gtttttcata
     5101 gcctgagcgt agtttttcgt ctgggataac ctgctcatcc tgcaaaagag ccaaagaatg
     5161 gtattgttgt aaatactcat cacattcatc acaccagcgt tggtcttccg ggtcccaaaa
     5221 aatggtcatc aagtcgcttc tacttttata aagaggcgat tcttgttcca atctaaacca
     5281 gcaagttttg tagtatttga gagcatcata atactggtca aattttctac ttgctacaat
     5341 atcttcttcc caaccttcta agaaccacca cggttcaaaa tctccgtaca tttctataac
     5401 acgatacata ttcattcatt cctttgtacc gtatattata accaattccg ccagacaagg
     5461 aaagaaatat gctcatttct taattttttg ataaaaaatc caaccatctg atggatgact
     5521 gaatttctat ttacttatgt acaaaaatat ttttactact taggcttctg agatatcgtt
     5581 ttcgataatg accttaatgg catggtggtc tgctgcctta ctgaagactt cgtaggcttt
     5641 ttcaatttca ctgagtttga aatagtgagt taccaatttt tctggttcaa tcttatgact
     5701 ttcaagtgct ttcaacaatt gtggagtcgt atttgtagat accaaaccag ttgttacatt
     5761 gatgttgcga atccaaagtt tatctaaatc gaattcaact ggtttaccat gcacaccaca
     5821 gttggcaacc gttccgtcta caccgataat cttttgacag aaatcaaatg tttcaggaat
     5881 ccctacagct tcaatagcga catctacacc gcgaccatct gtcaaatcat aaatttcttt
     5941 tatcgctttt tcagggtctg aagagtttac cttatgagta gcaccgaatg atagggcagt
     6001 atccaaacgg ttatcatcca agtccaccat aatcaattta gctggtgaat agaattgggc
     6061 tgttaaaaga gcagccaatc caactggacc tgaaccaata atggctacgc tgcaaccagg
     6121 ttctactttc ccttttaaga caccaatttc atatccagta ggcagaatgt ctgacagcat
     6181 aaccaaagct tcatctgaca agtcttctgg agtatggtaa agagtattat ctgcatgagg
     6241 gacacgtaga tattcagcct gcataccatc aatcaagtga ccgaaaatcc agcccccttc
     6301 gtcttcacag tgggcataaa ttcctttttt acagtagtag catttaccac aggcacagac
     6361 gcaagaaatc aagaccttgt cacctttttt gaagttggaa actccttccc caacttcttc
     6421 aacaatccca attccttcgt ggccaagaat ggtaccactt tggcaagtag gaacatcccc
     6481 tttgataata tggaggtctg ttccacaaat agtggttttt acaatacgca caatagcatc
     6541 tgttggcttg cgaataactg gtttgtctac atcaacaaaa gaagcaagtc ctggtttaac
     6601 ataagtatag gctttcataa agcactcctc cgttttttta tttgtaatat ttatagttca
     6661 attgtaagcc tttttctttg tttcttcaag ctttttttgt gattttttta actttttatt
     6721 taccagtaaa gtaccctgta taaaaaagca gaagctagtc tctaacttct gccttctctc
     6781 ttatgcttga taacgtttca caccatctag gtaggttgct accaattcca aatctttatc
     6841 taatacgatg aagtcagcgt cgtagccttc acggatttgg ccacagacgt catcgatgtg
     6901 aacggattta gctgggttga agctggccat catgactgct tcatgcggat tcgcaattcc
     6961 ccattcgacc acattcttca aaccatcttt gagtttgagg atagaacctg ccaagttacc
     7021 tgtcgatttg aggcgtgcag ttccatttgc aacgacaact gggaattctc ccaacatata
     7081 atctccgtct tccaatcccc cagctgtcat acagtctgtg ataagagcga tgttttctgt
     7141 tcctttttgt ttgataagaa tttcgcaagc ctttggatct acgtggtgac catcacagat
     7201 caactctgca taggtatgtg gcaattggta catggctcca accataccca attcacggtg
     7261 agtcaaccca cgcattccat tgtaggcatg cacccaaaca ctcgctccag catcgactgc
     7321 ttttttggct tcatcaaaag tcgcgtttga atgtccaaga gcaaccgtca caccttcgcc
     7381 cgtaactgta cgaacaaagt cttccacccc atcacgttct ggtgcaaggg caattttatt
     7441 aagcaagcca tttgccgctt tttgccaaga atgaaactcc tcaacacccg ggtctctcat
     7501 ataagttgga ttttgtgccc ccttaaaagt ttctgtgaaa tatggacctt cataataaat
     7561 cccacgaatc ttagcacctg ttgcttcttt ataatggttt ccaagatttt cagtgactgc
     7621 aagcaattgc tcataagtgg ctgttaaagt tgtgggtaag aaactggtaa caccggtact
     7681 aagaagtcct tcactcatag tatgcaatgt accttcaatg ttgttgtcca tcacatctac
     7741 acctgcatat ccatgaatat gagtatccac aagacctggg gcaatgctat aacctgtata
     7801 gtcaatcacc tcagcccctt caggaatctg ctctacatgt tttccaaact tgccgtccac
     7861 aagttccaag taaccacctc gacgaactcc gtgtgggtag aaaaactgat ccgctttaat
     7921 atagttaggc ataatgttaa cctccttaaa agattgattc tacaatttat tatgtcaatt
     7981 acattataaa cctttctttt ttatttgtaa atggtataga cctatttttt ggagatattt
     8041 taaaagagct ggatttctcc aactcttctc ttttttaata caagttattt tgatttaacc
     8101 ggcttatctt gagctgtctg caaagctgtg gcaatcgtat ctgcatacaa ttttgctcct
     8161 gcttcgatag tgctactctc actcccgaaa tgaacctggt ctgttccagc ccaaatttct
     8221 ggatgctctt tcgcaacttg attccaatct gctatcgtaa tgtaaggtgt cttctctgcc
     8281 aattctctca tataggcagc agccttctca acgatggcat aggtctcttt tgtcttatct
     8341 ccctcataag gagtcaccaa aatcatacgg tgtcccttag gaagattttt cacgatactg
     8401 tcccagtcat ccttgtaatt ctcaggatta tttaccccag tcgcaatgac caccgtctta
     8461 ggtaaaaatt tattctggct attatttagc atgatttcat ttgcagtctt ggttgttacg
     8521 ctgacctgcg cgttaatctg tgctccagga agagctgtct gtagtgctgt atttgccctt
     8581 aaagccactg agtcaccaat taacatagtg ccatcagcaa ttcccaaact gtttgcatct
     8641 gcccgttctg ccatcacctt ggtctggcca atatttgttg cagcttgctt caagccatta
     8701 acagtcaagt ctgtctcaaa cgctcccact tgtggtgcca acaaggtcac catgcagaca
     8761 atgaaggtca agattcctgt acctgctgca agaattgcgt gaatataagg caggggacga
     8821 agagtttgta aaataggtgt gttcttgcct gcaatccaag gttccaatac atagaatgac
     8881 agactggcaa agccataaga acaaatcaga gtcagtaata cagcaagaag atttgatgtc
     8941 aactgtgaga aaatgatata gaaaggccaa tggaaaagat aaaccgcata gctagtatcc
     9001 gctaaaaagc tgataatctt cggctcctgt atatgatgtg tcttttcatg taagacacgc
     9061 gccgccagaa tcatggcaag agctgcaaga ctggcaagca agaagccgat aagataggca
     9121 aaaagataag tgaatttgac aaagaaagtc aaaagaacta ggaaaccaaa gcctcctcca
     9181 aaaactacca aagtctttcg taaatcccag attttatcca actgcttgac gagggaagtc
     9241 gtctgacgaa cgcctacaat agttgctaac atacttccca aaaagaatgg atagacatga
     9301 gttaaactgg agaaataaac agaggaataa gaggtcacta gaaaactacc aataaacatg
     9361 gagaagaaac tgatcaagaa ggcagcagca gataagagaa agaccatccc cttcaactga
     9421 ccatttgatt tagcttgttt ggataagaac caaactgcca atccccaaag aatatagtag
     9481 tgaacctcaa ctgccaaact ccaattatga acaaacaaat gaggaatgaa ctgagattca
     9541 taactcccac ctgttaggag ttcatagaag ttggtcataa agcctaagac gcccgcaatc
     9601 tggccaccaa ttccagcaac atagtcttgg cgaaccaaga aagtaaaagg catggtcacc
     9661 aagaccatca aaaccacagg tggcacaatc cgataaaagc gtcttctaaa aaatcctatc
     9721 aaatcaatct cattgttctt agaaaattct tcaatgagta gagctgtaat caggaaacct
     9781 gaaaatgtga aaaagacatc taccccgaag aatcctccag gaaagatcgt ctgaaagaag
     9841 tgatacaaga gtaccaaaag taaacctgta atcctaacca aggaaaacca tttaatgcgc
     9901 atacgagttt attcttcctt tcattgtaca ctttattcta tcaaaaaaag aagaaaaatc
     9961 ctaagagaaa acttaggatt tttagcttat atcaattcca ttttagaaat tacgtcctga
    10021 cttattatag ccatattttt ccacaaaata cttacggaat tccaagagat tgtcatccat
    10081 gatggcttgt cgcacttgct tcatcaggtt aagcaagaag taaagattgt ggtagctagt
    10141 caagcggata ccaaaggttt catcagcctt gagcaggtga cgaaggtaag cgcgtgtata
    10201 gttattacat gtgtagcaat cacactcagg atccagtggc gtaaagtcct cagcaaactg
    10261 ggcatttttc acaaccaaac gtccttgact ggtcatacaa gtcccgttac gagcaattcg
    10321 agtcggtaag acacagtcaa acatatccac cccacgaatg accccatcga tcaagctatc
    10381 tggcgctccc acacccatca gataacgagg tttattttca ggcagcagtt gagttgtaaa
    10441 gtccaagacc gcattcatct cttcatgggt ttctcccact gccaaaccac cgatagagta
    10501 gcctgagaaa tccatgctga caagatcatg agctgattgg cggcgaaggt cttcaaatcc
    10561 tgcaccttgc acaattccaa acaaaccttg gtcatgtgga cgacggtgag ccttcaaacc
    10621 acgctcagcc caacggctgg tacgctcgat cgatttctta acgtagtcat aaggttgata
    10681 aaactgagga cattcatcaa aggacatcat gatgtctgaa cccagattat tctgaataga
    10741 gatggctttt tctggggata ggaacatctt agaaccattt agatgatttt taaaggttac
    10801 tccttcttct gtgatattac ggctatctgc taaagaataa acctgaaaac caccactatc
    10861 tgtcaagata ggctggtccc aattcatgaa cttgtggaga ccaccagcgc gtgcaatgag
    10921 ttcatctcca gggcgaagcc agagatgata ggtgtttgat aggataattc ccgaacccat
    10981 ctccttcaat tcttcaggtg actgagtttt gacagtggct tgtgtcccaa ctggcataaa
    11041 cataggtgtc ggaaaggtac cgtggggagt gatgatttct cctagacgag ctcctgtgtg
    11101 tttttctttc ttaatcaaac gatatttgat tggtgaatct gacatttttt acctccgaag
    11161 ctgggaaaga cagtcccagt tcatacagtg tgcccaagga cacactgtat gattttatca
    11221 aaaaaagtag gaactgtcac gaactatgta taagaactat ggtataataa gagaatgaac
    11281 tatccaaaaa ttgatttaaa aacaattcgt caggagtcaa aacattttca ggctgacacc
    11341 ccccgtctct ttctcctcta tatccttccc agtatgctgg tcatcttatc tggttttctt
    11401 aatcccttat ctcggatcca cgggactgtt ttagaacagc catttttcag catacttggc
    11461 caaatacttc aagcctacct ctttcctcta ctagtctcct ttatcgggac tattcttttg
    11521 accagttccg tctatgcaac actgacactc atgaaagatt ctaaaacgga gccatctgta
    11581 aaaaacagcc tagctctctt tgatgaggag cgcttttctc aaaccttttt gaccctactt
    11641 ctcaaacgtt tctatctctt tttatggagt atccctaatt tacttgggat ttacctcctc
    11701 ttttatagta gctttttagc caaaaaattc gtcaccctac atcctgagtt tccaaatcta
    11761 gatctctcat cagttgaaac cgagcgtttc ctcatggtct ttggactcta ctttcttgca
    11821 agtctcatct tgatcattgt aggaaatatc ctctatattc cacagtatta tgcctattca
    11881 caggtggaat ttcttctctg ttatagttta gacctaggac aggtcccacc aagacgaatc
    11941 ctaaaaacta gccgttcctt tatgaagggc tacaagttcc agcgctttgt cctagattta
    12001 cagcttcttc cttggtactt cctcaattgg attacctttg gcattgctag tttttcactc
    12061 ctaccttata tccaatgcac taaaattatg ttttaccgag cagtattggc tcgaaaacgt
    12121 ccaaaagctt gaaggttttt cccctcaagc ttttttctat caatgagttt ctccgcctac
    12181 caacttgagt tcctgatctc catgttctat catagcgccg attgctgctt ctatccctcg
    12241 ccgaatatcc actaaactca tagttggagt agtcggtctg ttcaccacct gttccatcat
    12301 ataaggaata tgcataaaac ctgccttaac atatggaaat ttcttttcta ccaaatagag
    12361 agcctgatac atcaaatggc tgcagacaaa agtccctgcc gtattggaaa cagaggccgg
    12421 taatccttct tttttatagc ttgaaccatc gctttaatcg gcaaactact aaagtaggcc
    12481 gaagcaccat ctgggcgaat gggacggtca atcggttgat tatcttcgtt atcagaaatg
    12541 cgtgcatcgt cttgattaat gaccactcgt tcaggtgtca aactagttct tccaccagct
    12601 tgcccaatac aaaggacaaa gtcaggttga taacgattca tctcttcttc caatacttga
    12661 gcagatttgt gaaaaactgt cggcacctct agccaacgga cctcagcacc atggatttca
    12721 gctggtaaac ctttaatggc ctccaaagct ggattgccct tttcccctcc aaagggctca
    12781 aaacctgtca ctaatacttt catttctaac tcctcaaaac caattcaatg agactttttt
    12841 cttaaaaaca agtataacat atttccctta ttctggattg aaaaggatta gcgagattag
    12901 aatcgacctt caagtgtatt taaagagtaa aatactaatc aaggccaaaa tagctgatcc
    12961 accttgcttc aaaataattt ttttatccgc tgttaaagag ccgtaagtcg cagcaccaat
    13021 cacaaataag acaaaaatag tcacaatttc taaattctgt gagaaataaa tgccatacaa
    13081 gagaaagact cctagcagag ccttataaat cccttgattt tttaacaata aacttactga
    13141 cggatgagcc aattcttcct tttccatatt aaatacacga ctagtcgcat ctgattgcgt
    13201 ggcaatactt tccaaataaa aaatgtaaaa atgctccaaa gcaacgatcg ttgttaaaat
    13261 aattgacatc tatttctcct taaatttcta tattttcaat acccaaaacc aatttattta
    13321 ataaacggct gagttctgtt ctctcaaact ctgttaagat actttctatc tcttccttaa
    13381 ccctgatatg ttgcagaggg ggattcacca ctaactgctc cttggcatac ttcgcagcct
    13441 ctaccaacac ttcccgctga ttttcaggat tacgatgacg ctccaccaaa ccttccgttt
    13501 ccaaaatttt gaaatgccgt gtcaaagcag cctgatcaat tttcaaacgc tcctgaaccg
    13561 ccatttggtt acaaggagaa tgctccagca aaaacagtaa aatctgatac cgtgtcaaac
    13621 taatcccaag ccttttttca aacaattgcg tactcgcttg ctcagacaag cggagttgat
    13681 acagtaaatc ttgaatctct agcatttctt cccctctctt tttattgatt tatcaatatt
    13741 tgactaatta attgtgatat aaagtaaaat agattgcaag aatgttgctt aactcattac
    13801 aagatgataa ctttccattt tccattcaaa ttgatactca atgaaaatca aaaagcaaac
    13861 taggaagcta gtcgcaggtt gctcaaagca cagctttgaa gtttcagata aaactgacgt
    13921 ggtttgaaga gattttcgaa gagtatgaca aagaaaaaac gaacgagaat cgctttccat
    13981 cacgaaagct agatctcatt cgtcaaaatg atgttatcaa gtcgggttta tccattcatt
    14041 gaaacgtgaa cgtgatcata gtgattttct gtcacactac cacggtctgg cattgggttc
    14101 caagtgttag ctggcccata tttgctatcg aatggagcat agaaacgttg tttccagatg
    14161 atgtaactaa tgccacggct ggccatattt tgaatagcat attccgcaat cttatcccct
    14221 aattctgaac gttctggtac cataaagtcg atagccaaac cttttccgtg atctccactg
    14281 tctcctggac gataaccact aaaggatgta atgccaaaca agttagcaat ttcttcttta
    14341 aaggcagctg tttgtggttg aagacctgca ttttcagatt ttgctactgc aagtccagca
    14401 taatcgggcg cagctggagc ctcgtaagtt gttgaaatta ttttcgtctc ttctggttga
    14461 taagtagaaa ctgctgctgt agctccattt gatgatgcta cttcttttgc ttctgaactt
    14521 gttgtagtta cttccactgc tgatgcagct tgagggcttg cttgtgtttc ctgcttctca
    14581 gctggagtcg tttcctgagg agttgcttct tcaactgggc gagttgtttc ggtcgtttgc
    14641 tcctctggga cagaagtgcc cgtagatggt gccacttctt cagaagcaat cactgtcttt
    14701 gtaacttctg caattggttg agaaaggtct gcaacctgaa cagtttgatc atcaacggtc
    14761 acttgattag tggtcaaatc tgctgtcgca gttgtcactt cttcactaga gtctgcttga
    14821 ggtgtttgga tttcaacttc tgttacttct tctgcttcat tgacagtcgt tgtcaaaaca
    14881 gtttctggga aaatcaagtc catattagtg attttgttca gattcgcaag cactgtgaca
    14941 tctacaccca aggcttctgc aatggtgctc aaagtatcac catactgtac ggtataactt
    15001 gttttgttgt ccgttttagt caaatcgttt tggatttgct caacactacg tgcagtccaa
    15061 agaacttctt ctgcttgagt tgccaatact ggggcaaatg acaaggctac tgttgacgct
    15121 aataacattc ttttcttcat tctttcaaat tcctttcaaa tgagtacctg tctatcataa
    15181 cacaaaaaat gtagaaaaaa agccctctcg ggcctattta acagaactgt ctattccttg
    15241 taacaaacta ggttacttga aatagtttgt taggtctctg tcacaaaact gacacaatct
    15301 ttttatcact tagtctcaaa aatacgggaa atatctgcta acgcttgaat cctgtgattc
    15361 ccttcataag tagactctaa aaagttgatg ctttgaatcc cactattctg ggcaaattcc
    15421 acatccagag tccgatcccc tatataataa gtattatcag aattcaactg atacttatct
    15481 agcagatagg tagccgcttc tggacttggc ttctggactt ggcttccgca caaagccact
    15541 ctgactggtt aaaatctctt taaaatagga ttccaccccc aagtccttga gaatggtaaa
    15601 agcgttgttc cccttatgag tatatataaa ctgctgaatt cctgattcgt ctgcccaagc
    15661 tagcacctca cgcgcacctg gcatcaaaac tacctgagca ttcttctcag ccagactctg
    15721 ggcacgcacc tgatttagca cctcaacatc cagatttcta tcttctgcca cccgcacaag
    15781 caaatcttgc accgaatact tgaagataaa ctctctcacc ttctccttat cataaggaat
    15841 agaaaactga gcaaaagtct cctcaatccc tgataaaatc gcttcgtaag agtccaataa
    15901 agtcccgtct aaatcccaaa taaaagctgt tttttgcatt tcctatcctt tcaagctcat
    15961 atagcgctgg taacgatagc gtagaaataa ccagcgaaaa ccattatcca agagagaccc
    16021 tgcccaaata ccaggcaagc cccaaccaag cacaatcccc atcagatatc ctgtcccaat
    16081 gcggatacac cacattccta tacttgtcgc ataaaaaggg aggcgtgcat ttcctaatcc
    16141 ctgccagact gccgtataga tgactgttcc tgtcgtcata ggggtcccaa gtagtgaaaa
    16201 cagtgtcact agaacactag cctccaccgc tagagaatca gtcgtataga gatgagttaa
    16261 tggtacaccc aagacatata tactaaagga caggggcaac atgaggaaca gagaaagcca
    16321 aaaggtttgt ttactcaaac tagcaactct tttccaatca tcctctccaa ctgctcgggc
    16381 caacagcatg accgttgccg tagcgacgcc aaaggcaggc atatagttaa actgggtcaa
    16441 gacttctccg attgcattcc cagcaactgc ctccgtccca aaagaaacga ccaaggcaat
    16501 gatcactaca tctccagccc tcatcataag tcgctctcca gctgctggta aagccaaggt
    16561 caacagttcc ttatctaaac caaaagttgg cttcccataa ggcagtttta attgtgacca
    16621 caaaatcaca agaccaacca aacgagacac aattgtcccc caagcaacac cagctatccc
    16681 catatccaga acaaaaatag ctagacttga aaaaagaata ttcaaggcat tggataaaaa
    16741 actaacatag agaggcagac gtggattatg cgttgcacga atcaaggctc ctagactagt
    16801 cattaaacct aagagaacaa tcgatccgcc taccaaagat agatacagtc caccactctc
    16861 agctacatcc ctctccgtcc ccaaaagtcc tatcatctct ttcccagcga agatggacaa
    16921 aaatcctaaa aggaaactta atagtaaggt aatcttcaac gcctcagtca catgataggc
    16981 caacttcgac tggtctttct gccctatgct ttttgaaata acactggaaa tagcagctcc
    17041 cagagcgatg aaaatcgcct gataaatggt gataatatta ccagctactg aaacccctga
    17101 aatagctatc aatcctaaat gagcaaccaa ataactgtcc accattccca ttagcatctg
    17161 caaaaagttt tcacccatag ctggcaatgc aatattaaga atgtctttat ttttcttaaa
    17221 caatctctcc tcctgatgaa aagaaactca gttggtttcc caaccgagtt tgctccctct
    17281 gtcttaaagt cctaaataag cctcaaccgc tgcttgcatg tcagcagctg ccactgttgt
    17341 cttgtgacga attggagcta tttcaagccc atcaactgct ggtggcactg caacgcctga
    17401 gatttcatgt aattgagcca aggcttcaaa gtctgttaaa cctgcttttc cagttacagc
    17461 ttctactgca actactggga acttgtatgg actagctgtt gaagcaatca ctgtcttagt
    17521 tacatctcca gtggccgatt ggtatttttt ataaactgct gaagcaacag ctgtatgagg
    17581 gtcctcgata taagaatcta actcacaaac acgcttgatc tctgctgccg tttcttcctc
    17641 agtcgcatat tcagctgcaa agaggtccaa aatctctgca tcaaagtctg tcaacttata
    17701 ttgtccttgc gtgttcaagg cattcataag ttcagttgtc ttttcagcat tatttcccaa
    17761 aagatggaaa atcaagcgct ccaagtttga agataccaag atatccatag atgggctggt
    17821 tgttacctta aactcacgtt ttttgtcata gacacgtgtt ttaaagaagt ctgtcaaaac
    17881 attgttgtca tttgaagcac agattaattt accaactggc aaaccaattt gtttggcata
    17941 aaaggcagcc aagatatttc caaagtttcc tgttggtact gtgaagttaa ccttttcacc
    18001 agctacaatt tcaccagtct taaccaattg agcgtaagca taaacataat aaacaatttg
    18061 tggcaccaga cgaccaatgt tcatagagtt agctgatgaa aattgcaact tgttggtagt
    18121 caatttttca cgaagagcca cgtcgttaaa catgtgcttc acatttgttt gcgcatcgtc
    18181 aaagttacca tcaatagcaa taacatgagt attgtcgcca gtctgagtgg tcatttgtaa
    18241 ctcttgaatc ttgctgacac catcctttgg ataaaagacg ataatctcag taccaggcac
    18301 attcgcaaac cccgccatag cagctttccc cgtgtcacca gatgtcgctg tcaagataac
    18361 aatcttgttc tccaaaccat gtttcttagc agcagtcgtc ataaagtatg gcaaaataga
    18421 caaggccata tccttaaagg caatcgttga accatggaaa agttccaaat tgtattgccc
    18481 atctaatttc actaatggtg caatagctgg agtatcaaat ttgctatcgt aggcattgtt
    18541 gatacagtag tccaactcct caactgtaaa gtcatctaaa aatgctgaca aaactagctt
    18601 agcaacttcc tggtaagaag catctttcaa tttgtcaaag ttcaaatcta cctttggata
    18661 agtaaccggt gtaaacaaac cgccgtccgt cgccaaacct tgcaaaattg cttggctggc
    18721 agttactgta ttgttggcat cacgcgttga ttgataaact aatgtcatta ctctctatcc
    18781 tttatctata gtctcgtcca ttatatcatg atttttcaga aaattctccc tttataagag
    18841 aaattatagg ctcaattctt ctctcaaagg ctgtaaatag gtcatttctt ccttatttct
    18901 caccactagt ccctcctcag ctagtaggag taagtctttg gaaaattcaa taatcgtagt
    18961 ttcttcctca tctgtaagat ttttcttaga aaattgtctc cttaaagact tgtaatcata
    19021 accaaatact ttaaagaaag gtgctgtttc taagtaagct tctaacttgt ctaaattaac
    19081 caataatccc aagtgaaaag ctgcagaagc aaaagtccta tcaagtggct gtgtacacac
    19141 actacgaaac tcaactgttc ctcgagtcgt taaatcttgg tactggtaac tacgatgagt
    19201 ttcaaaatcc ttctcttggg ggtaaataat aacctcatcc ccattcagag caaatgcttg
    19261 gatttcggac gtagccaaat agtccccagc ctgaatagga taaaaataat aggtctgccc
    19321 atcacgttcc gcagtaaaaa tcgcagaatg atttagatag tcaaaaaaat cagcttcatc
    19381 attaaggagt ctagcattga ccccaacatt ctctggatag ataccatgca tagattcttc
    19441 ccagaaaata tcccttgaaa ttttcgtatc ccaatccgca cccgaaaatt cagagtttgc
    19501 aaataaataa gccttagccg cttcaatttg agtaaaagca ttaatcaccc gtaagtagtt
    19561 ggtttttgaa atatccagct gaacctggct cccacagata aaagtaccat attcagggaa
    19621 atgatgtaaa tctgatttaa taatatttct actcaaattc aaataatcca tcaacatctg
    19681 atagcgtgga taagccactg gacaattctc atttttatcc cagttgggat ggataccaca
    19741 gccaacaata gcatgatttg attcagctaa ctttctctga attacattca tataattatt
    19801 gaaacgattt tcgacctctt gaatcgtttc agccttacca aatgcaaact caatcgttgt
    19861 ataggaaact tcaaataaaa tagcatcctg acttatcgga tctactaact ggatcagatt
    19921 gccaaaatca tctacctttg ctacggtgag atccaaagta gaaactaaat aatgaaatag
    19981 atccttcata acttcaacat ctgtagcatc cccttctaaa cttgcaacag gatactccaa
    20041 ctcaattccg acaaacaatt caggattttc tttaatattt ttcaaatacc gatgttttaa
    20101 taaatcgata gaacaagaca tactccccta cactttctta atctaaataa aatttgaata
    20161 actataatta taccaaaaat aatataaaaa aggaacgaag aataacaacg ttcctaacac
    20221 tatactatac cggcggccgg ggtcgaaccg gcacgtcctt gcggacactg gattttgagt
    20281 ccagcgcgtc tgccaattcc gccacgccgg caaatagtaa ctggggtagc tggattcgaa
    20341 ccaacgcatg agggagtcaa agtcccttgc cttaccgctt ggctataccc caatataaaa
    20401 taggcgagtg atggggatcg aacccacgca tgccagagcc acaatctggt gtgttaacca
    20461 cttcaccaca cccgccataa ttctattaac acgggcagta ggaattgaac ccacactgaa
    20521 ggttttggag accttagttc tacctttaaa ctatgcccgt aaaatggaag gggagggatt
    20581 cgaacccccg aacccgaagg agcggattta cagtccgccg cgtttagcct cttcgctacc
    20641 cttccaaaat atataaatgg cgcgagacgg aatcgaaccg ccgacacatg gagcttcaat
    20701 ccattgctct accaactgag ctaccgagcc ttattgcggg agcaggattt gaacctacga
    20761 ccttcgggtt atgagcccga cgagctaccg agctgctcca tcccgcgtta atataaaagg
    20821 aggatgtggg attcgaaccc acgcacgctt ttacacgcct gacggttttc aagaccgttc
    20881 ccttcagccg gacttgggta atcctccaaa atagtttata cgggaacaag cccgtgtcct
    20941 cttagtgaac agataatatt ccaatcccct agtaatggac taaacactat gggcacgagt
    21001 ggactcgaac caccgacctc acgcttatca ggcgtgcgct ctaaccacct gagctacgcg
    21061 cccaagtcaa aaacttggta caaagaacaa agttcaaagc gggtgacgag aatcgaactc
    21121 gcgacaacag cttggaaggc tgtagtttta ccactaaact acacccgcta aa
//
LOCUS       DAVHSO010000036        21077 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.036, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000036 DAVHSO010000000
VERSION     DAVHSO010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21077)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21077)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21077
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.036"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(376..2103)
                     /gene="ezrA"
                     /locus_tag="VVR18_001359"
     CDS             complement(376..2103)
                     /gene="ezrA"
                     /locus_tag="VVR18_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation ring formation regulator EzrA"
                     /protein_id="HEU6032865.1"
                     /translation="MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEE
                     LYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSF
                     RFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
                     AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIV
                     DRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENI
                     RQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLG
                     EDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDL
                     QTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTF
                     LKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQ
                     LLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSY
                     EKTRETIRF"
     gene            complement(2185..4131)
                     /gene="gyrB"
                     /locus_tag="VVR18_001360"
     CDS             complement(2185..4131)
                     /gene="gyrB"
                     /locus_tag="VVR18_001360"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HEU6032866.1"
                     /translation="MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLH
                     HLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVF
                     TVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVAD
                     LEVVGDTDRTGTTVHFTPDPEIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQG
                     LEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVM
                     SFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISV
                     KHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARV
                     AAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQ
                     AILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDAD
                     VDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQ
                     EALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDM
                     LMGDRVEPRREFIEENAVYSTLDV"
     gene            complement(4146..4709)
                     /locus_tag="VVR18_001361"
     CDS             complement(4146..4709)
                     /locus_tag="VVR18_001361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEU6032867.1"
                     /translation="MKYHDYIWDLGGTLLDNYETSTAAFVETLALYGITQDHDSVYQA
                     LKVSTPFAIETFAPNLENFLEKYKENEARELEHPILFEGVSDLLEDILNQGGRHFLVS
                     HRNDQVLEILEKTSIAAYFTEVVTSSSGFKRKPNPESMLYLREKYQISSGLVIGDRPI
                     DIEAGQAAGLDTHLFTSIVNLRQVLDI"
     gene            complement(4794..5348)
                     /locus_tag="VVR18_001362"
     CDS             complement(4794..5348)
                     /locus_tag="VVR18_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1/PfpI family protein"
                     /protein_id="HEU6032868.1"
                     /translation="MVKVAVMLAQGFEEIEALTVVDVLRRANITCDMVGFEEQVTGSH
                     AIQVRADHVFDGDLSDYDMIVLPGGMPGSAHLRDNQTLIQELQSFEQEGKKLAAICAA
                     PIALNQAEILKNKRYTCYDGVQEQILDGHYVKETVVVDGQLTTSRGPSTALAFAYELV
                     EQLGGDAESLRTGMLYRDVFGKNQ"
     gene            complement(5359..6582)
                     /locus_tag="VVR18_001363"
     CDS             complement(5359..6582)
                     /locus_tag="VVR18_001363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEU6032869.1"
                     /translation="MKRSLDSRVDYSLLLPVFFLLVIGVVAIYIAVSHDYPNNILPIL
                     GQQVAWIALGLVIGFVVMLFNTEFLWKVTPFLYILGLGLMILPIVFYNPSLVASTGAK
                     NWVSINGITLFQPSEFMKISYILMLARVIVQFTKKHKEWRRTVSLDFLLIFWMILFTI
                     PVLVLLALQSDLGTALVFVAIFSGIVLLSGVSWKIIIPVFVTAVTGVAGFLAIFISKD
                     GRAFLHQIGMPTYQINRILAWLNPFEFAQTTTYQQAQGQIAIGSGGLFGQGFNASNLL
                     IPVRESDMIFTVIAEDFGFIGSVLVIALYLMLIYRMLKITLKSNNQFYTYISTGLIMM
                     LLFHIFENIGAVTGLLPLTGIPLPFISQGGSAIISNLIGVGLLLSMSYQTNLAEEKSG
                     KVPFKRKKVVLKQIK"
     gene            complement(6619..9069)
                     /locus_tag="VVR18_001364"
     CDS             complement(6619..9069)
                     /locus_tag="VVR18_001364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional DnaQ family
                     exonuclease/ATP-dependent helicase"
                     /protein_id="HEU6032870.1"
                     /translation="MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTD
                     VNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIFDLVEDGIFVAHNVQFDANLLAE
                     NLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE
                     LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYF
                     KKTAASLELRKLSQDFSKNISLLNLEVREEQESFAKEVGLLLKDEPVFLIQAPTGIGK
                     TYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKL
                     DAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLS
                     SQSLFVTEDFWKRSQERAETCKLLVTNHAYFVTRLEDNPEFVSDRLLIIDEVQKILLA
                     LENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNIL
                     DSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSGRTLLSSL
                     LPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTET
                     SLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKK
                     RFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKN
                     AFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIVASLAEEATVK
                     TISRSEVDEAIDRFFNEL"
     gene            complement(9269..10198)
                     /locus_tag="VVR18_001365"
     CDS             complement(9269..10198)
                     /locus_tag="VVR18_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006154193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEU6032871.1"
                     /translation="MEKIVITATAESIEQVEQLLEAGVDRIYVGEKDFGLRLPTTFSY
                     DQLREIAKLVHDAGKELLVAVNALMHQDMMDRIKPFLDFLEEIKTDYITIGDAGVFYV
                     VNRDGYSFKTIYDASTMVTSSRQINFWGQKAGASEAVLAREIPSAELFKMPEILEIPA
                     EVLVYGASVIHHSKRPLLQNYYNFTHIDDEKTHKRDLFLAEPSDPESHYSIFEDNHGT
                     HIFANNDLDLMIKLTELVEHGFTRWKLEGLYTPGQNFVEIAKLFIQARNLIQEGNFSH
                     DQAFLLDEEVRKLHPKNRFLDTGFYDYDPDMVR"
     gene            10338..10625
                     /locus_tag="VVR18_001366"
     CDS             10338..10625
                     /locus_tag="VVR18_001366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3270 domain-containing protein"
                     /protein_id="HEU6032872.1"
                     /translation="MPVRKLQSYEVDYQEELNQQLPHYQAYTPEAQSDANLKEILFFI
                     NIAVFCICIAIFSFIFLALKLSTALAFAVAIGFSLLVLKVQRSIIKRKRRR"
     gene            complement(10659..11993)
                     /gene="ciaH"
                     /locus_tag="VVR18_001367"
     CDS             complement(10659..11993)
                     /gene="ciaH"
                     /locus_tag="VVR18_001367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000491790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     CiaH"
                     /protein_id="HEU6032873.1"
                     /translation="MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLY
                     TSVDDKLHGLSENPQAVIQLAINRATEEIKDLENARADASKVEIKPNVSSNTEVILFD
                     KDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
                     IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQ
                     SFVENASHELRTPLAVLQNRLETLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLN
                     LARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRIHRTIVTDQLLLKQL
                     MTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKA
                     RTRQKGGFGLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK"
     gene            complement(11983..12657)
                     /gene="ciaR"
                     /locus_tag="VVR18_001368"
     CDS             complement(11983..12657)
                     /gene="ciaR"
                     /locus_tag="VVR18_001368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CiaR"
                     /protein_id="HEU6032874.1"
                     /translation="MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGV
                     YDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKP
                     FYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
                     FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGY
                     LLKDVQ"
     gene            complement(12766..15312)
                     /locus_tag="VVR18_001369"
     CDS             complement(12766..15312)
                     /locus_tag="VVR18_001369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001149089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HEU6032875.1"
                     /translation="MQAVEHFIKQFVPEHYDLFLDLSRETKTFSGKVTITGQAQSDRI
                     SLHQKDLEITSVEVAGQARPFTVDHDNEALHIELAEAGQVELVLAFSGKITDNMTGIY
                     PSYYTVDGVKKEVLSTQFESHFAREAFPCVDEPEAKATFDLSLRFDQAEGELALSNMP
                     EIDVENRKETGIWKFETTPRMSSYLLAFVAGDLQGVTAKTKNGTLVGVYSTKAHPLSN
                     LDFSLDIAVRSIEFYEDYYGVKYPIPQSLHIALPDFSAGAMENWGLVTYREVYLVVDE
                     NSTFASRQQVALVVAHELAHQWFGNLVTMKWWDDLWLNESFANMMEYVCVDTIEPSWN
                     IFEDFQTGGVPLALERDATDGVQSVHVEVKHPDEINTLFDGAIVYAKGSRLMHMLRRW
                     LGDADFAKGLHAYFEKHQYSNTIGSDLWDALGQASGRDVAAFMDSWLEQPGYPVLTVK
                     VENDVLKISQKQFFIGENEDKNRLWVVPLNSNWKGLPDTLETESIEIPGYAALLAENE
                     GALRLNTENTAHYITDYQGDLLEAVLAELETLDNTSKLQIVQERRLLAEAGHISYADL
                     LPVLDKLAKEESYLVVSAVSQVISALERFIDEGTDAETAFKGLVAKLARHNYDRLGFE
                     AKDGESDEDELVRQLAVSMMIRSNDAEASQVASQIFATHKENLAGLPAAIRSQVLINE
                     MKHHETKDLLALYLDTYTHATDAVFKRQLAAALAYSTDADNIQNLITSWKDKFVVKPQ
                     DLSAWYYQFLAHQATQKTAWSWARENWAWIKAALGGDMSFDSFVILPAHVFKTQQRLA
                     EYKEFFEPQLSDLALSRNIGMGIKEIAARVDLISREKAAVEAVVLQYGNA"
     gene            complement(15435..15875)
                     /locus_tag="VVR18_001370"
     CDS             complement(15435..15875)
                     /locus_tag="VVR18_001370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ASCH domain-containing protein"
                     /protein_id="HEU6032876.1"
                     /translation="MTPQEMWNKYKQINPLIGDEIDAWAFGVEPDLLADLVFKGEKTA
                     TASAYDLYVLEDEPLPQVGTFDVILDSQNQAVCIVEITKVSVELFNQVSAQHAFKEGE
                     GDKSLAYWRQVHEDFFTDCLGEVGLTFTPESKVVLEEFRKVYPL"
     gene            complement(15850..16497)
                     /locus_tag="VVR18_001371"
     CDS             complement(15850..16497)
                     /locus_tag="VVR18_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PEP-utilizing enzyme, TIM barrel domain protein"
                     /protein_id="HEU6032877.1"
                     /translation="MKNQLALSGEKILEKIYPLFGYRGTRRLLACLDEFQAEAHVITE
                     VYQTNPNLSVIFPFVNDADQLKQAITVLRQYGFTGKVGTMIELPSAYFDLSSILETGI
                     SKIVVGMNDLTSFVFATMRNSQWHDMESPIMLDMLRDMQDKARKNKINFAVAGYLNTS
                     FIQKMNQLGIKCIIHYSSIPEIFDLEIDHPDHLKHIKEESKKLQRSTHDTARNVE"
     gene            complement(16539..17267)
                     /locus_tag="VVR18_001372"
     CDS             complement(16539..17267)
                     /locus_tag="VVR18_001372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032878.1"
                     /translation="MELFKTWKKNMVLYGLKSQIGTVYRNNDRTTSFYDVGNFLYLAG
                     ELDSRFWEDFVRKYGLDYKIIISENTNWQDFLHRKVGLNSFTRYSFKDKANFQVEFLN
                     NLVTHLEEGYNIVPIDNHIYNCFSTEEWSQDLQGDFESYQDFVLKGGFGFVILKNNEL
                     IAGISSGLVYRKAVEVEVATRPNEQGNGFAKKLGAAMILESLNRDMFPLWDAHNEASK
                     KVAEFLGYELSEPYEAFELEEILI"
     gene            complement(17275..17754)
                     /locus_tag="VVR18_001373"
     CDS             complement(17275..17754)
                     /locus_tag="VVR18_001373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU6032879.1"
                     /translation="MEIKNHFGVYCVCFENGKLLCIEKTRGPYQHRYDLPGGSQQLGE
                     GLTETLTREVMEETGFTVRSYSNPRIYDVFVREELKNFMVHHVMALYDVEMNESAPQV
                     TISEAVSDGANDSLGYIWMDIQEITEENASPLVFKVKSELLGFPELDKTSYMNWKVK"
     gene            complement(17765..18463)
                     /locus_tag="VVR18_001374"
     CDS             complement(17765..18463)
                     /locus_tag="VVR18_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HEU6032880.1"
                     /translation="MTKRVLITGVSSGIGLAQARLFLEKGYQVYGVDQGEKPLLEGDF
                     RFLQRDLTLDLEPIFDWCPQVDVLCNTAGVLDDYKPLLEQTAQDIQEIFEINYIIPVE
                     LTRYYLTQMLENKKGIIINMCSIASSLAGGGGHAYTSSKHALAGFTKQLALDYAEAGI
                     QVFGIAPGAVKTAMTAADFEPGGLADWVASETPIKRWIEPEEVAEVSLFLASGKASAM
                     QGQILTIDGGWSLK"
     gene            complement(18456..18722)
                     /locus_tag="VVR18_001375"
     CDS             complement(18456..18722)
                     /locus_tag="VVR18_001375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2829 domain-containing protein"
                     /protein_id="HEU6032881.1"
                     /translation="MKNVELKEKNMTFEEILPGLKAKRKYVRTGWGGAENYVQLFDTI
                     EQNGLALEMTPYFLINVSGEGEGFSMWSPTVCDVLATDWVEVHD"
     gene            complement(18788..19714)
                     /locus_tag="VVR18_001376"
     CDS             complement(18788..19714)
                     /locus_tag="VVR18_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase family oxidoreductase"
                     /protein_id="HEU6032882.1"
                     /translation="MRYITLGQDDKELSEIVLGMMRIKDKSVKEVEELVETALSVGIN
                     AFDLADIYGRGRCEELLGLVLKNRPDLREKMWIQSKCGIRIEEFTYFDFSKDYIIKSV
                     DGILQRLKIDHLDSLLLHRPDALMESDQVAEAFNLLYKQGKVRDFGVSNQNPMMMELL
                     KKDVKQPLAVNQLQLSAAFTPGFESAFHVNMEDSQAAMRDGSIFEYCQLHDVVIQAWS
                     VLQFGYFKGNFVGNEKFQALNQVLDRLAIKYGVTSSTIAISWILRYPAKMQAVVGTTN
                     PKHLREVSRAANFSLTRKEWYEIYLAAGNNLP"
     gene            complement(19789..20604)
                     /locus_tag="VVR18_001377"
     CDS             complement(19789..20604)
                     /locus_tag="VVR18_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032883.1"
                     /translation="MKKMKYYEETSALLHEFSEENQKYFEELWESFNLAGFLYDEDYL
                     REQIYLMMLDFSEAERDGMSAEDYLGKNPKKIMKEILKGAPRSSIKESLLTPILVLAV
                     LRYYQLLSDFSKGPLLTVNLLTFLGQLLIFLIGFGLVATILRRSLVQDSPKMKIGTYI
                     VVGTIVLLVVLGYVGMASFIQEGAFYIPAPWDSLSIFTISLVIGIWNWKEAVFRPFVS
                     MIIAHLVVGSLLRYYEWMGISNVFLTKVIPLAVLFIGIFVLFRGFKKIKWSEV"
     gene            complement(20608..20928)
                     /locus_tag="VVR18_001378"
     CDS             complement(20608..20928)
                     /locus_tag="VVR18_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEU6032884.1"
                     /translation="MKETQLLKGVLEGCVLDMIGQKERYGYELVQTLREAGFDTIVPG
                     TIYPLLQKLEKNQWIRGDMRPSPDGPDRKYFSLMKEGEERVSVFWQQWDDLSQKVEGI
                     KNGG"
BASE COUNT         6379 a         4625 c         3688 g         6385 t
ORIGIN      
        1 taagaaatct ccagattagg aactatccgt gagttctcta gtctggagat ttttcaatag
       61 acttcgttat tggacggtta ccaagttact caaagtacag atttgaagct gcagataaga
      121 ctgacgaaat cactttaata ctaaatgaaa atcaaaaagc aaactaagaa gctagcctca
      181 ggctgtactt gagtacggta aggcgacgct gacgtgattt gaagagattt tcgaagagta
      241 taaaacactg ttttgaggtg gtggataaat cggctgagta aaaactcaat ctcaggagaa
      301 aatgaagtaa atctccccac aactatagaa aaagatttga ttctgctcct cacacaataa
      361 aatctttttc ttttattaaa aacgaatcgt ttcacgtgtt ttctcatatg aggtaacaaa
      421 gcgattggtt acaccaggct ctgccacttc caatgcttga gaaatcttgt caaatgaagc
      481 gtgataatca aattcttttt caaaaatatc taaagcttcg ttaaatgctt cttgaatgcg
      541 ttcatcaaat gagcgatagc ggttagaata ttgcaagagt tgctctgtca aagttgcata
      601 ttgtacaata ttataagttt ccgtttctaa agcttccata tcattcgttg caatttcaag
      661 aactcgggta acagattcaa tgttaatcat tttttgttct aactcaacca ttaaatcctc
      721 ggtattattg cttgccgtaa agaataactt caagaaagtt tgtggaatac ctggcagatt
      781 gcgtttttcc atgtatcgct tgatagtatg gagacgattg acataaacat tggccttttg
      841 acgtgcatta atatcatctt tctcaatttg tgtcaggcgc tcactaactg aaatttgctc
      901 atcttcaata tcttttagtt gagtttgtaa atcctcaaga ttttcttcaa gaactgaata
      961 agcttgggtt ggttcttctt gatttgaagt tacctcaaca atagctgcct caaaactctc
     1021 taattctgtc tgaatacgac gaacatggct tgcagctgtc tcaggaagta aataggtctt
     1081 gttcaaacgt gcaatatctt ctcccaataa agtattattc tctttcatat gttgaaggta
     1141 agttggaaga gttgcaagta gattttccac tactttctga gcagcaattt ctcgagtaaa
     1201 aatatcatac aaggcattga tttcctcttg tgcctgtcca ttctcatatt cggcattatc
     1261 caattccaac tgacgaatat tctcttggtt tttcttgaat gcttcataaa gcaagtggaa
     1321 acgcgcttca atatccgttt caacaaaatg ataattagca tcaattagtt tacgataacc
     1381 ggcttccaaa tcctgtaatt gatctggcaa ttctgtagaa agcgtcgtaa ccaaggctgg
     1441 aacacgatcc acaatatgac ttaaggccaa aatgtgattt tctgtattat ccaaaatcac
     1501 tgcggcttcc acagggtcac ccgatgaatt caaggttaca aattgtgaaa attcagattg
     1561 gatattttct aattgttttt caatttcatc caaggcttga ccatactgtt ctgaattttc
     1621 agcaactcta tgctgaagtt cctcaaataa atccaaagca tgaagaacac gaccactatt
     1681 tttagattct tgcttctcta agtctgccaa agcattgcga attgccgcaa tatcttcttc
     1741 aatcaaagta atttgactct caatttggtc aatttgatga ctggccttga gaaaacgaaa
     1801 tgaatggtta tagccttctg cttcaaagag attattttca atatcggcaa aagagttgag
     1861 agataaatcg acccattttt gattccattc acggaaagcc acttgacttt gtccaatcaa
     1921 gtgcatattt tttacagctt ctacttcatc atttactgga agattgtata gttcttcttt
     1981 tctttcttct agcgcctcta atctcccctc gtttcgctta cgtagaaaga ttgccactac
     2041 ataagccaga actaaaatga ctgcaattgc aaccattaaa taaattagtt gtccattaga
     2101 catatcaaac tcctttttta cttgaaacaa tcgtaacgat tatatcatat tttttagacc
     2161 aagggaacta cttctcccta ttttttagac atcaagtgta ctatagacag cattttcttc
     2221 gataaactca cgacgaggct ctactcgatc ccccatcaac atatcaaaga ttttatctgc
     2281 ttctgcagca tcatctacag aaactctagc catcaagcga tgttcgggat ccatggttgt
     2341 ttcccacagc tgatgatcgt ccatttcacc tagcccctta taacgctgaa tagtcggttt
     2401 ggtacgacct tcactataac gggctaaagc ttcttggagt ttgatttctt gatctgcacc
     2461 cggctggata tattctttaa tctcgcttcc aaccttgaca ccatagattg gtggttgggc
     2521 aatataaaca taaccagctt ctaggattgg tttcatataa cgataaatca aggttaaaag
     2581 aagggtacga atatgggctc catcgacatc ggcatcggtc atcaaaacga gtttttggta
     2641 acgggctttc gaaacatcaa attctgcgcc aaatcctgtt cccatggctg tgaaaagact
     2701 acgaatttct tcgttagcta gaatcttatc catacttgct ttttcaacgt tcaaaatctt
     2761 accgcgaatt ggaaggatag cctgaaactc acggttacga ccagatttgg ctgatccacc
     2821 agctgagtct ccttcgacga tgaagagttc tgtttcagca gggttattag aagaacagtc
     2881 tgctagtttc cctggaaggt tggaaatttc caaaccagat tttttacgtg tgacttcacg
     2941 cgcacgcttg gcagccacac gagccttggc agctaaaatc cctttttcca cgatacgttt
     3001 ggcaatctgt ggattttcca tgaggaaatc ggagaaggct tcactgaaga ggcgattggt
     3061 aatcttgacc acttcgctat ttcccaattt ggtcttggtt tgtccttcaa actgtggatt
     3121 tgggtgttta actgagataa ctgcagttaa tccttcgcga acatcttccc ctgttaaatt
     3181 atcttcattg tctttcagta acttattctt acgagcataa tcattgataa cacgagtcag
     3241 tgccgtacgg aaaccttgtt catgcgttcc accttcatgg gtatgaatat tattggcgaa
     3301 actcatgaca ttttcatggt aacctgttgt gtactgcatg gctacctcaa ctgtaatatc
     3361 atccatctca ccgtctgtat agattggtgt atcaaagatt acatccttgt tctcgttgat
     3421 atattcaacg taactagcaa tcccaccttc ataatgataa tgcttggttt gttccaaacc
     3481 ttggcgctta tcagtgatag aaatttgaag accgcgattt agaaaggcca actcttgaat
     3541 ccgtttattt aatttatcaa aatcaaagat tgttgtttca gtgaaaattt ctgggtccgg
     3601 tgtgaagtga accgttgttc cagttctatc tgtatcccca accacctcaa ggtctgcaac
     3661 aacatgacca cgacggtatt cttggtaatg aatcttaccg tttttatgga catgaacgtc
     3721 taattgagtg gaaagggcat taactactga cgaccccacc ccgtgaagac cacctgaaac
     3781 cttgtatcca ccaccgccga actttcctcc agcatgaagg actgtaaaga cggtctcaac
     3841 agcaggacgg cctgtttttt cctgaatatc gactgggata ccacgcccat catccacaac
     3901 agtaatcgaa tcatctggct caataaaaac ttgaatatgg ctggcaaatc ctgccaaggc
     3961 ctcgtcaatt gagttatcaa caatttccca gactagatgg tgaagacctt cttttgaggt
     4021 tgatccaatg tacatccctg gacgcatacg aacagcctct aagccctcta aaacttgaat
     4081 ttgactggca tcataatcct gtgcctgcag atttttgatt tcttctgtca tcttattcct
     4141 ttttcttata tgtctaatac ttgtcttaaa ttcacgatac tggtaaacaa gtgggtatca
     4201 agtcctgcag cttgacctgc ttcgatatca atcggccgat caccaatgac aagaccagag
     4261 ctaatctgat acttttctct taaataaagc atggattcgg gatttggctt tctcttaaag
     4321 cctgagctag aagtcaccac ttctgtaaaa taagctgcta tagaggtttt ttctaaaatt
     4381 tccaaaacct gatcatttcg atgagagacc aaaaaatgac ggccaccttg atttaaaatg
     4441 tcttccaata ggtcagaaac tccttcaaat aaaatcgggt gttcaagctc tctggcttca
     4501 ttttccttgt acttttctaa aaaattctct aaattgggag cgaatgtctc aatcgcaaaa
     4561 ggagtagaaa cctttaaagc ttgatagaca ctgtcatggt cttgtgtgat accatacagt
     4621 gccaatgttt caacaaatgc agctgttgaa gtttcataat tatccagtaa agttccacct
     4681 aaatcccaga tgtaatcgtg atatttcata cccttcatta tagcattttt ttatgaaaaa
     4741 agcgatgatt tccctgagtt ttccacataa aaaacgagag aataactccc gttttactga
     4801 tttttaccaa agacatctcg atagagcatt cctgttcgta aactctctgc gtcccctcct
     4861 agttgctcca ccaactcgta ggcaaaggca agggctgttg aaggaccccg actggttgtc
     4921 aactgaccat ctaccactac tgtttccttg acgtagtgac catcaaggat ttgctcttga
     4981 acgccgtcat aacaagtgta tcgcttattt ttcaatatct ctgcttgatt gagggcaatt
     5041 ggtgccgcac aaatggctgc tagtttcttc ccttcttgct caaagctttg caattcttga
     5101 atcaaggtct gattatcacg taaatgtgca gaaccaggca tacctccagg aagaacaatc
     5161 atatcatagt ctgataaatc tccatcaaag acatgatctg ctcttacttg gattgcatgc
     5221 gaacccgtta cttgctcttc aaaaccaacc atatcacatg tgatattggc tcgacgcaag
     5281 acatctacaa ctgtcaaggc ttcaatttct tcaaagccct gagctaacat aactgctact
     5341 tttaccatga ttttctcctt atttaatttg ttttaataca acctttttcc gtttgaatgg
     5401 gacttttccg ctcttttctt cagctagatt agtctggtaa ctcatcgata aaagcaaacc
     5461 aacaccaatc agattactga taatagctga tcccccttgc gaaatgaaag gcaagggaat
     5521 ccccgtcaaa ggaagtagtc cagtcacagc accgatattc tcaaagatgt ggaagagcaa
     5581 catcataatc aaacctgtgg aaatataagt gtagaactgg ttatttgatt taagagtaat
     5641 cttcaacata cggtaaatca acatgagata gagggcaata accaggacag agccaataaa
     5701 gccaaaatct tctgcaataa ccgtaaaaat catatctgac tctcgaactg ggataagcag
     5761 attcgaagca ttaaatccct gaccaaataa gccaccactc ccaatggcaa tctgcccttg
     5821 agcctgctgg taagtcgttg tttgggcaaa ctcaaaggga ttgagccaag ccaaaatccg
     5881 attgatttgg taggtcggca ttccaatctg gtgaagaaaa gctcgtccgt ccttgctaat
     5941 aaagatagct aagaaaccag caactcctgt tacagcagtc acaaatactg ggataataat
     6001 tttccaagaa acccctgata ataaaacgat tcctgagaaa atggctacaa aaaccaaagc
     6061 cgtccccaag tcactttgaa gtgctaaaag aactaggact ggaatggtaa agagaatcat
     6121 ccagaaaatt aacaaaaagt ccagcgaaac cgtgcgtctc cattccttat gtttctttgt
     6181 aaattggaca atgacacgag ccaacatgag gatataggat atcttcataa attctgacgg
     6241 ttgaaatagg gtaattccat ttattgatac ccagtttttg gcacccgttg atgcaactaa
     6301 gcttggatta taaaatacaa tcggcaagat cataagtccc aagcctaaaa tatatagaaa
     6361 gggggtcacc ttccaaagaa attctgtatt aaagagcatg accacaaaac caatcacaag
     6421 ccccaaggca atccaggcga cctgctgccc taaaatgggc agaatattat tgggataatc
     6481 atgactaacg gctatataga tagccaccac accgatgacc agtagaaaaa atactggcaa
     6541 gagcaaactg taatcgactc ttgagtcgag agaacgtttc atatatacta accttatact
     6601 ttcatacaat actatttatc aaagttcatt aaaaaatcta tcaatagcct cgtcaacttc
     6661 ggatcgagag atggttttaa cagtcgcttc ttctgctaga gatgctacta tttgtttgcc
     6721 gtatcgtttt ccgacgattc tcctatccaa aataagagtt aaggaacgtt ggtattcacg
     6781 tctcatactt cttcccaaag cctgttttaa acgaataatg gccattggca attgataatc
     6841 ataaaaggca tttttccctt cttgattcag ttcttgatta atctttttcg tcaagggttc
     6901 ttgaggattt tggaaaggaa gcctcggtac aacttgaatc acaaaaggat ggcttgaaaa
     6961 atcaactccc tcccagaaac ttgctgcacc aagcaagatt tgttgttcac ctttttcaaa
     7021 gcgtttcttt agctgatgaa catccccatt tttatactgg gccaagtggc taactgtaag
     7081 taaatccgat actgctagaa gcatgtcttt agcggtaaag agaaccaaaa tcggttgctg
     7141 gaaagcttga atttccacta gtaaagcagc tacctctctg gcatagactt ctaaggaggt
     7201 ttctgttacc agagggaaat ctttgaccat aaccacttct tgttcctgtt ttccccgaga
     7261 ttcaatcttg acaaatttag cttcaggata gcctaaaagg tctgccaaag aaaccctctg
     7321 actaatctca agagtagccg atactcccag gacttggcaa ctctcaggaa gtaaagagga
     7381 cagaagagta cggcctgatt ttgtagaaga aatctgaatt ttcttttgac tcgtttcagt
     7441 tacttcaagc cagtaatcac cttcagctgt aaaatagcga accagctcat caaagccttc
     7501 tacttctaat tctgaaaaat actgatggag attgtccaga gaatctaaga tatttttcct
     7561 agatttacca gactgaaatt gttctatcaa gtagagacac tcaaagcgaa tactttctag
     7621 tatccgttgt tgaaccctgt tttcttctcc tactaaagcc ttatcaatta aatcgataat
     7681 agattgtata tcgtaggtct cttgaagcag attttctaga gctaacaaaa tcttttggac
     7741 ttcatcaata atcagtaaac ggtcactgac aaattcagga ttatcttcaa gtctggtcac
     7801 gaaataggca tgattagtca ctaaaagctt gcaagtctct gccctttctt gactacgttt
     7861 ccaaaaatct tccgtcacaa ataagctctg ggatgataaa ttcccatcat gacgaaggtc
     7921 tgctagaaaa tgttggtaac ggtagagttg cccgatttca tccaaatctc ctgtctctgt
     7981 ctcagtaagc cagaccaaga cttgcatttt aaagcgtcta aataagcgat tttcatcatt
     8041 ttcctgcaag gaatgataaa aggcatccaa cttcagataa ttttgtggtc cctttaagct
     8101 atgaatatct gtatggaaca cttccttgag acgtttacct tcttcttcca tgatttgatt
     8161 ttgaagaatc tttgtcggaa cactaagaac aatttgtcgc tctttggatt gagataaagc
     8221 gggtaagaga tagccatagg ttttcccaat ccctgtcggc gcttgaatca gaaagacagg
     8281 ttcatctttc aatagcaagc caacctcttt agcaaaactt tcttgttcct ccctcacttc
     8341 aaggttcaac agagaaatat ttttagaaaa gtcttgagat agttttcgta gctccagaga
     8401 agctgccgtt ttcttaaaat acagaccttg aacttggacc aagtctggag aactcaggat
     8461 agattggttg cgataagttt cctcaataac caggtaggac tcatatagga gagcgtcagc
     8521 catttccagc aagcgttcca agagaccttt aggaagctgg gtcatctttt cccgtaaaaa
     8581 aagaagtaat tctgctgtag cttgggcatc tgaaagggct gtgtgtgcgt gtttaagagg
     8641 aattcctaat tctcgacaca aaatcggcaa gctatatttt tccagttcag ggaaaaagac
     8701 ctgggccaat tcgaccgtat caacacgagg gtttcttagc tcatagcctt caaaaaataa
     8761 attttccgcc aagagattag catcaaactg aacattatgg gctacaaaaa tcccatcctc
     8821 caccaagtca aatatttttc tggcaacttg cgaaaaatca ggtgcttgcg ccagacgttg
     8881 gtctgtcaat cctgtcagtt ctttgatatg agcatccaag ggttcatgtg gattgacatc
     8941 cgtcgtatag tgatcgacga tttctccgtc ctcaatcacg acaattccca cttggataat
     9001 tttagcctta ctacctgtgc tagttgcctc taaatccacc acaacatagc gattaccaat
     9061 cgttttcatt ataaaaaatt ataccaaaaa aagggccatt tggcacctgc aaacatagga
     9121 taattttcaa actcaagaac actacttttc ttaaaaatcc catcgaatag agcattctag
     9181 cctgctgatt tttgtaaaat agtgaagaaa tacgaaaaat tgagagaaga aatgtttgca
     9241 tcttccttct ctcaacgaat catgtatttt atctaaccat gtcaggatcg tagtcataaa
     9301 atcctgtatc aaggaaacgg tttttagggt gaagtttacg aacttcttca tccagcaaga
     9361 aggcttgatc atggctaaag ttgccctctt gaatcaaatt acgcgcttgg ataaagagtt
     9421 ttgcaatctc aacaaagttc tgaccaggag tgtagagccc ttctagtttc cagcgagtaa
     9481 agccatgctc caccaattct gttaatttga tcatcaaatc aaggtcattg ttggcaaaga
     9541 tatgggtccc atgattatct tcaaaaatgg aatagtggct ctctggatca cttggctcag
     9601 ccaagaagag gtcacgttta tgcgtctttt catcatcgat atgtgtaaag ttatagtagt
     9661 tttgcaagag tggacgttta gaatgatgga tgacgctagc accgtaaacc aaaacttcag
     9721 caggaatttc caaaatctct ggcattttga aaagttcagc tgatggaatt tcacgcgcca
     9781 aaacagcctc agatgcgcca gccttttgtc cccagaagtt aatctgacga ctgctagtta
     9841 ccatggttga agcatcgtag atggtcttaa atgaataacc atcgcggtta actacgtaaa
     9901 agacgcctgc atccccaatc gtaatatagt ctgtcttgat ttcttccaag aagtctaaga
     9961 aaggcttgat acggtccatc atatcttggt gcatgagagc attgaccgca acgagcaatt
    10021 ccttaccagc atcatgaacc aacttagcga tttcacgtaa ttggtcataa ctaaaggtcg
    10081 ttggcagacg aaggccaaaa tctttctcac cgacatagat acggtctacg ccagcttcga
    10141 gtagttgttc aacttgttca atactttcag cagttgctgt aatgacaatc ttttccataa
    10201 gaaaaattat accacatttc tccaaaatca tccatgcttt gaaaatgaaa agggacttta
    10261 ttctttttgt aacctttctg taataattct ctgccgaaaa aatgataaaa taggtatgta
    10321 ctgttaagga gagaattatg cccgtaagaa aattacaatc ctatgaggta gactatcaag
    10381 aagaattaaa ccagcagctt cctcattacc aagcttatac acctgaagcg caatctgatg
    10441 ccaatctcaa ggaaatccta ttttttatta atatcgctgt tttttgtatc tgtattgcta
    10501 tctttagttt tatcttttta gcattaaaat tatcaactgc tcttgccttt gccgtagcaa
    10561 tcggattcag cttacttgtt ttaaaagttc aacggtctat tatcaaacga aaacgtagaa
    10621 gataaatcca aaatatcgcc ccaattggag cgatattttt attttttctt tttagatggt
    10681 gtctgaatgg caatcttcac ttcaaagatt gttcccttgg gtttattatc tttgacagta
    10741 acagttcctt ttagagcatc tacaatttgc ttggctaggg ataatcctaa accaaaacca
    10801 cctttttgcc gggttctagc cttgtctact cgataaaaac ggtcaaaaat tttcttttta
    10861 tcttctgtcg aaataccgat tccattatca gaaacaagta aataaagatt gcgatcggtc
    10921 gccgagataa gaaaatcaat ttcaccatcc tcctcagtat acttgacggc attatcgaaa
    10981 agaatggtca tcagttgttt cagaagaagc tgatctgtga caattgttcg atggatacga
    11041 ttttcaaaac ggaagacacg attattttcc gaagcaatca tctcatagtt tgtgaaagtt
    11101 gtattaaaaa agctagttgg aacttctgca agctccggct taatcccatc atctctccga
    11161 gctaagttca gcaagcttgt cgttaaaaaa cgcatatttc ggacttcttc caaactcgat
    11221 gcaatgcttt cgctcacatc cataatggta gcttctggct tacgaaaaag ggtctctaag
    11281 cgattttgca aaactgcgag tggagttcgt aactcatgac tggcattttc cacaaaagac
    11341 tgttgcttct gcatactctc aagcaggggc ctaacactga ccctagctag atagagactg
    11401 gcaagtaaag acaaaatcca gaaactagcc atcacgacca caatcaattg ctcatgcttt
    11461 tgactagcct gctccaactg actggtatta atcaagacag cagcatactt gatattggtt
    11521 gaaaccgaac taatattggt ctccatcaaa atcacacgat agatttcttc ctgcccatag
    11581 ctattaaaaa cctgaatctg gtagatatgt cctagttctt tcttttctaa cttaatctta
    11641 tccaagccca aaaatcgatt tccagaaaga agttgagtaa agtctttatc aaagagaatg
    11701 acttccgtat tggaactgac attaggtttt atttctactt tactagcgtc cgccctagca
    11761 ttttctaaat ctttaatctc ttctgttgcc ctatttatag ccagctgaat aactgcttga
    11821 ggattttcac tcagtccatg aagcttatcg tccaccgaag tataaagact cgaatgcatg
    11881 acttgtaaaa taatcagagt cattgtagaa aaaatcaggg tgaagacacc gaagttgcgg
    11941 ataaaataac taaagtcatc cgcataccat gtttttttaa gtttactgaa catcttttaa
    12001 aagataccca acactacgca aagtttgcaa attctctgca aaagtggttc cctttaattt
    12061 cttacggact tttgaaacat agacttcgac aaccgaaatc gttgtatcac tatcaaatcc
    12121 ccatagacgg tcaaaaatct gcgtcttagg caaaatcaca ttttgatttt gaaggaaata
    12181 aactagtaaa tcgaactctt tccccagcaa ttcgacagga gtatcttcaa ctttaacggt
    12241 attggttgat aaattaacca cgatattccc ataagtcaag gtgttttcat taaacttccc
    12301 tgaacgttta agaagggcct gaatccgcat tttaagttct tctaggtaga aaggtttggt
    12361 cagataatca tccgctccca gttcaaatcc atgtcccttg tcatccaaac tttccttggc
    12421 agtcataatc agaactggtg tcgtaattcc cttttcacgc aattctttta agacttggaa
    12481 accatttttt tctggcaaca tcaaatccag caaaatcaag tcatagacac cactctcagc
    12541 ttcgtagaga ccttcttctc catcaaatac ctgcataaca tccgcaaaat cgtctaaaaa
    12601 gtcaaatact gaatttgaca gacctaggtc atcctcaacc aataagattt ttatcatgag
    12661 aaactcctcc ttattaaaac tattatacca aatttgcctt aaaaaaaact caactctctg
    12721 cattttacat gagatagctg agttttcttt ttattttagg cttatttatg catttccgta
    12781 ttgaagaaca actgcttcga ctgcagcttt ttcacggcta atcaagtcaa cacgtgctgc
    12841 aatttccttg attcccatac cgatgttacg gctaagagca aggtcagaaa gttgcggctc
    12901 aaagaactcc ttgtattccg ccaagcgttg ctgagtctta aatacatgag caggaaggat
    12961 aacaaagcta tcaaagctca tatctcctcc aagggctgcc ttaatccaag cccagttttc
    13021 acgcgcccaa gaccaagctg ttttctgagt tgcttgatga gctaggaatt ggtaatacca
    13081 agcagacaag tcctgtggtt tgaccacaaa tttgtccttc caagaagtaa tcaagttttg
    13141 gatattatcc gcatctgtac tgtatgcaag agctgctgcc aactggcgtt taaagacagc
    13201 atctgttgcg tgagtataag tatcaagata aagtgctaac aagtctttag tctcatgatg
    13261 tttcatctca ttaatcagaa cttgtgaacg aatagctgct gggagtcctg caagattctc
    13321 cttgtgtgtt gcgaagattt ggctagcgac ttgactagct tctgcatcat ttgagcgaat
    13381 catcatcgaa acagccagct gacgaaccaa ttcatcctca tctgattctc cgtctttagc
    13441 ttcaaaacca agacggtcat agttatgacg agccaattta gcaaccagtc ctttgaaggc
    13501 tgtttcagca tccgttcctt catcaataaa gcgctcaagg gctgaaatca cttgagaaac
    13561 agctgaaacc accagataag actcttcctt agcaagttta tcaagaactg gaagcaagtc
    13621 tgcataagaa atgtgccctg cctcagccaa caaacgacgt tcttgaacaa tttgcagttt
    13681 gcttgtgtta tcaagtgtct ctagctcagc aagaacagct tctaacaagt ctccttgata
    13741 gtcggtaata tagtgggcag tattttcagt gttgagacga agagctcctt cattttcagc
    13801 aagaagagct gcgtagccag ggatttcgat actttcagtt tcgagtgtat caggcaagcc
    13861 tttccagttg ctattgaggg gcaccaccca gagacggttc ttgtcttcgt tctcaccgat
    13921 gaagaattgt ttttgtgaaa tcttcaagac atcattttca actttgacag taagaactgg
    13981 gtaaccaggc tgttccaacc aagaatccat gaaggctgcg acatcacgtc ctgacgcttg
    14041 accaagggca tcccaaaggt cactaccaat ggtgttgctg tattggtgtt tttcaaagta
    14101 ggcgtgcaaa cctttagcaa aatcagcatc tcctagccaa cggcgaagca tgtgcatgag
    14161 acggcttcct ttggcataga cgatagcgcc gtcaaagagt gtattgattt catctggatg
    14221 tttaacttcg acgtggacag actgaacgcc atcagtagcg tcacgttcaa gagcaagagg
    14281 tactccacct gtttggaaat cttcaaagat attccagctt ggttcgatgg tatccacaca
    14341 gacgtattcc atcatattag cgaaactttc attgagccaa aggtcatccc accatttcat
    14401 agtcacgagg ttcccaaacc attggtgagc caattcatgg gccacaacaa gggcaacttg
    14461 ttgacggcta gcaaatgtag agttctcatc gacaaccaag taaacttcac ggtaggtcac
    14521 aagaccccag ttttccatag caccagctga gaagtcagga agggcgatgt ggagagattg
    14581 aggaattggg tacttaactc catagtaatc ttcgtaaaac tcgatagagc gaacagcgat
    14641 atccagtgag aaatcaagat ttgaaagtgg atgtgctttg gttgagtaga cacctaccag
    14701 ggtaccattt ttagttttag cggtcacccc ttgcaaatca ccagcaacaa aggccaacaa
    14761 gtaagaagac atgcgaggtg ttgtctcaaa cttccagata cctgtttcct tacggttttc
    14821 aacatcgatt tctggcatgt ttgacaaggc caattcacct tctgcttggt caaagcgaag
    14881 agagaggtca aaagttgctt tggcttcagg ctcatccaca cacgggaaag cttcacgcgc
    14941 aaaatggctc tcgaactgag tagacaagac ctccttcttg actccatcaa ctgtataata
    15001 agaagggtaa atccctgtca tgttgtctgt aattttacca gaaaaggcaa gaaccaattc
    15061 aacttgacca gcctcagcca attcgatatg aagggcttca ttgtcatggt caactgtaaa
    15121 tggacgagct tgacctgcaa cttctacaga ggtgatttcc aagtcttttt ggtggaggga
    15181 gatgcggtca ctctgtgctt gaccagtgat ggtcactttc ccagaaaaag tcttggtctc
    15241 acgactcaaa tctaaaaata aatcataatg ttcaggaaca aattgcttaa taaaatgttc
    15301 aactgcttgc atagttttct cctattctaa gtttaagagc tgctgctctt cttcaaacaa
    15361 acttattata tcatattttg cttgagaaaa aaggattgga cagcgatttc caaaactttc
    15421 ttccttctaa tagtctacag tgggtagacc ttgcgaaatt cttctaaaac aaccttgctt
    15481 tcaggtgtaa aagtcagccc tacttcaccc aaacagtctg tgaaaaagtc ctcatgaacc
    15541 tggcgccaat aggcaagtga tttgtctccc tcaccttcct taaaggcatg ttgcgcagaa
    15601 acttgattga agagttcaac agaaaccttt gtaatttcga caatgcagac agcctgattt
    15661 tgactatcta aaatgacatc gaaggtccct acttggggaa gtggttcgtc ttctagtaca
    15721 tagaggtcat aggctgatgc tgttgctgtc ttttctcctt taaacaccaa atccgctaaa
    15781 aggtctggtt caactccaaa agcccaagca tcgatttcat ctccgatcaa aggattgatt
    15841 tgcttgtatt tattccacat ttcttgcggt gtcatgggta ctcctttgta attttttact
    15901 ttcttctttt atgtgtttaa gatgatctgg atggtcaatc tctaaatcaa aaatctctgg
    15961 aatagaactg tagtggataa tgcacttgat acccaactga ttcatttttt gtatgaaaga
    16021 agtattcaga tagcctgcta cagcaaaatt aatcttgttc tttcttgctt tatcctgcat
    16081 atctcttagc atatctaaca ttattggact ttccatatca tgccattgac tgtttctcat
    16141 agtcgcaaaa acaaaggaag tcaaatcatt cattccaact acaatctttg aaatgcccgt
    16201 ttccagtata ctagataagt caaaatacgc tgacggtaat tcaatcatcg ttccgacttt
    16261 cccagtaaag ccatactgac gcaatactgt aatagcttgt tttaattggt cggcatcatt
    16321 gacaaaagga aagataacag atagattggg gttggtttga taaacttctg taatgacatg
    16381 tgcttcagcc tgaaattcat ccaaacacgc cagtaaacgc ctagttcctc tatagccaaa
    16441 cagaggataa attttttcaa gaattttttc gccactaagg gcaagttgat ttttcatagc
    16501 cattcacctc gtcttaaaag atacaatatc atatataatt atatcaaaat ttcctctagt
    16561 tcaaaagctt cataaggttc agataactca tatcctaaaa attctgctac ttttttggaa
    16621 gcctcattat gagcatccca aagtggaaac atatctctat ttaaactctc tagaatcatt
    16681 gcagcaccaa gctttttagc aaatccattt ccttgttcgt ttggtctagt tgcaacttcc
    16741 acttcaactg ctttacggta aactaaccct gaggaaatcc cagcaatcag ttcattattt
    16801 ttaagaatca caaagccaaa tccacctttt aaaacaaaat cctgatagga ctcaaaatcc
    16861 ccctgtaaat cctgtgacca ttcttccgta gaaaagcagt tataaatatg attatcaata
    16921 ggcacaatat tgtaaccttc ctctaaatga gtaactagat tatttaaaaa ttcaacttga
    16981 aaatttgcct tatctttaaa agaatagcga gtaaaagaat ttagccccac ttttcgatgc
    17041 agaaaatctt gccaattagt attttctgaa ataataatct tataatctaa accatatttt
    17101 ctaacaaaat cttcccaaaa tctggaatcc aactcccctg ctaggtatag aaaattccca
    17161 acatcataaa agcttgttgt cctatcattg tttcggtaga cagttccaat ttgagattta
    17221 agaccataga gaaccatatt tttcttccat gttttaaata gttccattat ccctctactt
    17281 caccttccaa ttcatgtaag aagtcttgtc cagttctgga aatcctaata attcagactt
    17341 aaccttaaag actaatggcg atgcattttc ttctgtaatc tcttgaatat ccatccaaat
    17401 atatccaagt gaatcattcg caccatcaga cacagcttcc gaaatcgtaa cttgaggtgc
    17461 actctcattc atttcaacat catacaaggc catgacatgg tgaaccataa aattttttaa
    17521 ctcttctctg acgaaaacat cgtagattcg aggattagag tagcttctaa cagtaaatcc
    17581 cgtctcttcc ataacttctc tagtcagcgt ttccgtcagt ccttcaccaa gttgctgact
    17641 gcctccaggt agatcatacc gatgttgata aggacctctc gttttttcaa tgcagagtaa
    17701 ctttccattt tcaaagcaaa cacagtagac cccaaagtga tttttgattt ccatccaact
    17761 cctcctactt caaagaccag ccaccatcta ttgtcagaat ttgtccctgc atggcagatg
    17821 cctttccact ggccaaaaag agactgactt ctgccacttc ctctggttca atccagcgct
    17881 tgattggtgt ttcactagcc acccagtcag ctaagccacc tggctcaaaa tccgcagcgg
    17941 tcatagctgt cttgactgct cctggagcga taccaaagac ctgaatccca gcttcagcat
    18001 agtctagagc caactgcttg gtgaagccag ccaaggcatg cttggatgaa gtataggcgt
    18061 gaccacctcc acctgctagg ctagaagcaa tggaacacat attgatgatg attccctttt
    18121 tattttccag catttgtgtc aaataatacc gagtcaactc tactggaata atgtagttga
    18181 tttcaaaaat ctcttgaatg tcctgcgccg tttgttccaa cagtggtttg taatcatcca
    18241 aaactccagc agtattacac aaaacatcca cctgagggca ccagtcaaaa ataggttcca
    18301 agtccaaggt caaatctctc tgtaaaaagc gaaaatcacc ctctaagagt ggcttttcac
    18361 cttggtcaac tccataaact tgatagccct tctctaaaaa gaggcgagct tgagccaatc
    18421 cgatccctga actcactcct gtaatgagta cacgtttagt catgcacttc tacccaatcc
    18481 gttgccaaaa catcacaaac tgtcgggctc cacatggaaa aaccttctcc ttcgccagaa
    18541 acgttgatta ggaaataagg tgtcatttca agtgcaagcc cattttgctc gatggtatca
    18601 aagagttgga catagttttc cgcacctccc caaccagttc gtacatattt tctcttagcc
    18661 tttaacccag gcaggatctc ttcaaatgtc atgtttttct cctttaattc tacattcttc
    18721 atttaattat agcaaaaaac cgctttatac ggctttttaa atgtgagtta ttcaaacctg
    18781 ctactactta cggcaaatta ttccctgcag caagataaat ttcataccat tcttttcttg
    18841 ttaagctaaa gtttgccgct cggctaactt ctctcaagtg cttaggattt gttgtaccta
    18901 cgactgcctg catttttgct ggataacgca atatccaaga aatggcaata gttgaagagg
    18961 ttactccata tttaatagct aaacgatcaa gtacttgatt taaagcttga aatttctcat
    19021 ttccaacaaa attcccttta aaatacccga attgtaagac agaccatgct tgaatgacca
    19081 catcgtgtaa ttggcaatat tcaaaaatgc tgccatctcg catagctgct tgactatctt
    19141 ccatattaac atgaaaagct gattcaaatc ctggagtaaa agccgcactc aattgtagct
    19201 gattaacagc taacggctgc ttgacatctt ttttaagcaa ctccatcatc ataggatttt
    19261 gattagaaac tccaaaatct cgaactttac cttgtttata aaggagatta aaggcttctg
    19321 ctacttggtc agattccatc aaagcatctg gtcgatgaag gagcaagcta tctagatgat
    19381 caatcttcaa tctttgcaaa ataccgtcta ctgattttat aatatagtcc ttagaaaaat
    19441 caaaataggt aaattcttca atgcgaatgc cacatttgga ctgaatccac atcttttctc
    19501 ttaaatctgg acgatttttt aggacaagac ctaacagttc ttcacaacga ccacgaccat
    19561 aaatatcagc caagtcgaag gcattgattc caacagaaag tgctgtttct acaagctctt
    19621 caacttcttt tacagattta tcttttattc tcatcattcc gagaacaatt tctgataatt
    19681 ctttgtcatc ttgaccaaga gttatgtatc tcatcaaatt tttctccttt aatttctaac
    19741 attcttccct tcattataac aaaaaaccgc tttgcaacga ctttttgact atacttcact
    19801 ccattttatc ttcttaaacc cacggaacaa gacaaagatt ccaataaaga ggacagctaa
    19861 aggaataact tttgtaagga aaacatttga aattcccatc cactcataat aacggagcag
    19921 agaacccacc acaagatggg caataatcat actgacaaat ggacgaaaga ccgcttcttt
    19981 ccaattccaa ataccgataa ctagcgaaat cgtaaagata gacaaactat cccagggagc
    20041 cggaatataa aaggctcctt cttgtatgaa gcttgccatt cctacatatc ctaaaacaac
    20101 tagaagaact atagtcccaa caacaatgta agtgccaatt ttcattttag gagaatcttg
    20161 gactaaactt cttcgtaaaa ttgtggccac aagtccaaat ccaatcagaa aaataagaag
    20221 ttgccctaaa aatgtgagca aattgactgt taagagagga cctttagaaa aatcacttag
    20281 tagttgataa taacgtaata ccgccaggac aagaattggc gtcaaaaggg actctttgat
    20341 agaactgcga ggtgctccct tgagaatctc tttcattatt tttttaggat tcttacctag
    20401 ataatcctct gcactcatgc catctcgttc tgcttctgag aaatctagca tcatcaaata
    20461 gatctgctct ctgagatagt cttcatcata gagaaatcca gcaagattaa aactttccca
    20521 caactcctca aaatactttt gattctcctc agaaaactca tgtagcaaag cgcttgtttc
    20581 ttcgtaatac ttcattttct tcatggttta acccccattc ttaatccctt ctactttttg
    20641 actcaaatcg tcccattgtt gccaaaagac tgagacacgc tcttctcctt ctttcattaa
    20701 tgaaaaatac ttccgatctg gaccatctgg cgacgggcgc atgtcgcctc ttatccattg
    20761 atttttttct aacttttgca acaaaggata aatagttcct ggaacgatag tatcaaatcc
    20821 agcctctcgc aaagtctgaa ccaactcata accataccgc tctttttgac caatcatatc
    20881 caagacacaa ccttcaagaa caccttttaa tagctgagtt tctttcatca cttctccctt
    20941 ctaatctatt ttgtaatacc tactagtaac ttcacctata gtatattact tctacactag
    21001 tttgtaaagc ataatagtta atactcttcg aaaatctctt caaaccacgt cagcgtcgcc
    21061 ctaccgtatg tatggtt
//
LOCUS       DAVHSO010000037        20858 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.037, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000037 DAVHSO010000000
VERSION     DAVHSO010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20858)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20858)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20858
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.037"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(200..1120)
                     /gene="cysK"
                     /locus_tag="VVR18_001379"
     CDS             complement(200..1120)
                     /gene="cysK"
                     /locus_tag="VVR18_001379"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HEU6032885.1"
                     /translation="MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVK
                     DRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVER
                     RKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
                     ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPH
                     KIQGISAGFIPDTLDTKAYDGIVRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIE
                     VAKKLGTGKKVLALAPDNGERYLSTALYEL"
     gene            complement(1405..2040)
                     /locus_tag="VVR18_001380"
     CDS             complement(1405..2040)
                     /locus_tag="VVR18_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HEU6032886.1"
                     /translation="MEFRTIKEDDQVQEEIKKSRFICHAKRVYSEEEARDFITAIKKE
                     HYKATHNCSAFIIGERSEIKRTSDDGEPSGTAGVPMLGVLENHNLTNVCVVVTRYFGG
                     IKLGAGGLIRAYAGSVALAVKEIGIIEIKEQAGIAIQMSYAQYQEYSNFLKEHDLMEL
                     DTNFTDQVDTMIYVDKEEKETIKAALVEFFNGKVTLTDQGLREVEVPVNLV"
     gene            2096..3394
                     /locus_tag="VVR18_001381"
     CDS             2096..3394
                     /locus_tag="VVR18_001381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU6032887.1"
                     /translation="MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCN
                     STILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKV
                     SEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKR
                     LQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPTL
                     YHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLNLPRRFHGNPLIIPKPIWLSD
                     FNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLEEILQEQFPNEKIGFVS
                     SVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGG
                     RVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL"
     gene            3391..4053
                     /locus_tag="VVR18_001382"
     CDS             3391..4053
                     /locus_tag="VVR18_001382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HEU6032888.1"
                     /translation="MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEEN
                     CPNCMKTELSTKCQDCQLWCKEGVEVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFA
                     SFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
                     KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSL
                     VR"
     gene            4132..4680
                     /gene="raiA"
                     /locus_tag="VVR18_001383"
     CDS             4132..4680
                     /gene="raiA"
                     /locus_tag="VVR18_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000599099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HEU6032889.1"
                     /translation="MIKYSIRGENLEVTEAIRDYVVSKLEKIEKYFQPEQELDARINL
                     KVYREKTAKVEVTIPLGSITLRAEDVSQDMYGSIDLVTDKIERQIRKNKTKIERKNKN
                     KVATGQLFTDALVEDSNVVQSKVVRLKQIDLKPMDLEEAILQMDLLGHDFFIYVDVED
                     QITNVIYRREDGEIGLLEVKES"
     gene            4816..6789
                     /locus_tag="VVR18_001384"
     CDS             4816..6789
                     /locus_tag="VVR18_001384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HEU6032890.1"
                     /translation="MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVG
                     GYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTSLLEQMPVGVMKLNLSSGEVEWFNP
                     YAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR
                     EQAITDELVTSRPVIGIVSVDNYDDLEDATSESDISQINSFVANFISEFSEKYMMFSR
                     RVSMDRFYLFTDYTVLEGLMNDKFSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIG
                     KVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRTRTRTRAMMTAISDKI
                     RSVDQVFVVGHKNLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFIEK
                     EGVTKLLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQTIVIDHHRRDQDFP
                     DNAVITYIESGASSASELVTELIQFQNSKKNRLSRMQASVLMAGMMLDTKNFTSRVTS
                     RTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGCKLGSDVLIAEAKDTKCY
                     DTVVISKAADAMLAMSGIEASFVLAKNTQGFISISARSRSKLNVQRIMEELGGGGHFN
                     LAAAQIKDVTLSEAGEKLIEIVLNEIKEKEKEE"
     gene            6786..7238
                     /gene="rplI"
                     /locus_tag="VVR18_001385"
     CDS             6786..7238
                     /gene="rplI"
                     /locus_tag="VVR18_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HEU6032891.1"
                     /translation="MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATAQAV
                     GELRGKQKSEEKAHAEMIAEGKAIKAQLEAEETVVEFVEKVGPDGRTFGSITNKKIAE
                     ELQKQFGIKIDKRHIQVQAPIRAVGLIDVPVKIYQDITSVINLRVKEG"
     gene            7281..8633
                     /gene="dnaB"
                     /locus_tag="VVR18_001386"
     CDS             7281..8633
                     /gene="dnaB"
                     /locus_tag="VVR18_001386"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HEU6032892.1"
                     /translation="MAEVEELRVQPQDILAEQSVLGAIFIDESKLVFVREYIESRDFF
                     KYAHRLIFQAMVDLSDRGDAIDATTVRTILDNQGDLQNIGGLSYLVEIVNSVPTSANA
                     EYYAKIVAEKAMLRRLIAKLTESVNQAYEASQPADEIIAQAEKGLIDVSENANRSGFK
                     NIRDVLNLNFGNLEARSQQTTDITGIATGYRDLDHMTTGLHEEELIILAARPAVGKTA
                     FALNIAQNIGTKLDKTVAIFSLEMGAESLVDRMLAAEGLVESHSIRTGQLTDEEWQKY
                     TIAQGNLANASIYIDDTPGIRITEIRSRSRKLAQETGNLGLILIDYLQLITGTGRENR
                     QQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIV
                     AFLYRDDYYERGGEEEEGIPNNKVEVIIEKNRSGARGTVELIFQKEYNKFSSISKREA
                     "
     gene            8635..8901
                     /locus_tag="VVR18_001387"
     CDS             8635..8901
                     /locus_tag="VVR18_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001278167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032893.1"
                     /translation="MSDAFTDVAKMKKIKEEIKAHEGQVVEMTLENGRKRQKNRLGKL
                     IEVYPSLFIVEFGDVEGDKQVNVYVESFTYSDILTEKNLIHYLD"
     gene            8990..10108
                     /gene="cbpD"
                     /locus_tag="VVR18_001388"
     CDS             8990..10108
                     /gene="cbpD"
                     /locus_tag="VVR18_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase CbpD"
                     /protein_id="HEU6032894.1"
                     /translation="MKILPFIARGTSYYLKMSVKKLVPFLVVGLMLAAGDSVYAYSRG
                     NGSIARGDDYPAYYKNGSQEIDQWRMYSRQCTSFVAFRLSNVNGFEMPAAYGNANEWG
                     HRARREGYRVDNTPTIGSITWSTAGTYGHVAWVSNVMGDQIEIEEYNYGYTESYNKRV
                     VKANTMTGFIHFKDLDGGSVGNSQSSASTGGTHYFKTKSAIKTEPLVSATVIDYYYPG
                     EKVHYDQILEKDGYKWLSYTAYNGSRRYIQLEGVTSSQNYQNQSGNISSYGSHSSSTV
                     GWKKINGSWYHFKSNGSKSTGWLKDGSSWYYLKLSGEMQTGWLKENGSWYYLGSSGAM
                     KTGWYQVSGKWYYSYSSGALAVNTTVDGYRVNSDGERV"
     regulatory      10191..10293
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            10364..10654
                     /locus_tag="VVR18_001389"
     CDS             10364..10654
                     /locus_tag="VVR18_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine-binding protein"
                     /protein_id="HEU6032895.1"
                     /translation="MKASIALQVLPLVQGIDRIAVIDQVIAYLQTQEVTMVVTPFETV
                     LEGEFDELMRILKEALEVAGQEADNVFANVKINVGEILSIDEKLEKYTETTH"
     gene            10617..11375
                     /locus_tag="VVR18_001390"
     CDS             10617..11375
                     /locus_tag="VVR18_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009013602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6032896.1"
                     /translation="MRNLRSILRRHISLLGFLGVLSIWQLAGFLKLLPKFILPTPLEI
                     LQPFVRDREFLWHHSWATLRVALLGLILGVLIACLMAVLMDSLTWLNDLIYPMMVVIQ
                     TIPTIAIAPILVLWLGYGILPKIVLIILTTTFPIIVSILDGFRHCDKDMLTLFSLMRA
                     NPWQILWHFKIPVSLPYFYAGLRVSVSYAFITTVVSEWLGGFEGLGVYMIQSKKLFQY
                     DTMFAIIILVSIISLLGMKLVDISEKYVIKWKRT"
     gene            11413..12420
                     /locus_tag="VVR18_001391"
     CDS             11413..12420
                     /locus_tag="VVR18_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU6032897.1"
                     /translation="MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFIL
                     DWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLPPEESSSDLVINGKAPFAVYFQDYMAK
                     KLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAMLKTLVE
                     SQGGDFEKVEKVPNNDSNSITPIANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYV
                     KEFDYYSPVIIANNDYLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKE
                     KRDFVIESQKYLSKEYASDKEKWGQFDAARWNAFYKWDKENGILKEDLTDKGFTNEFV
                     K"
     gene            12420..13148
                     /locus_tag="VVR18_001392"
     CDS             12420..13148
                     /locus_tag="VVR18_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032898.1"
                     /translation="MTEIRLEHVSYAYGQERILEDINLQVTSGEVVSILGPSGVGKTT
                     LFNLIAGILEVQSGRIVLDGEENPKGRVSYMLQKDLLLEHKTVLGNIILPLLIQKVDK
                     AEAISRADKILATFQLTAVRDKYPHELSGGMRQRVALLRTYLFGHKLFLLDEAFSALD
                     EMTKMELHAWYLEIHKQLQLTTLIITHSIEEALNLSDRIYILKNRPGQIVSEIKLDWS
                     EDEDKEVQKIAYKRQILAELGLDK"
     gene            13267..13725
                     /locus_tag="VVR18_001393"
     CDS             13267..13725
                     /locus_tag="VVR18_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HEU6032899.1"
                     /translation="MRFKNTSDHIEAYIKAILDQSGIVELQRSQLADTFQVVPSQINY
                     VIKTRFTESRGYLVESKRGGGGYIRIGRIEFSSHHEMLRELLYSIGERVSQEIYEDIL
                     QLLVEQELMTKQEMNLLESVALDRVLGEEAPVVRANMLRQVIQEVDRKGK"
     gene            13727..16159
                     /locus_tag="VVR18_001394"
     CDS             13727..16159
                     /locus_tag="VVR18_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001109706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEU6032900.1"
                     /translation="MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAG
                     ATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQVLFDEAEYVASVVHAKV
                     LGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
                     LRQRHRTVADKQNSMAHMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRM
                     IQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAG
                     TRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARG
                     TLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQ
                     ITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKANHVKADDSDLSPADKAL
                     MDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEA
                     ELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVL
                     FDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVE
                     KAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDI
                     RFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAE
                     KGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSTLKI
                     GVKAGQLKFDIA"
     gene            16801..17454
                     /gene="rr06"
                     /locus_tag="VVR18_001395"
     CDS             16801..17454
                     /gene="rr06"
                     /locus_tag="VVR18_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001024075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RR06"
                     /protein_id="HEU6032901.1"
                     /translation="MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLP
                     IHLMILDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDETTQSQVFDLYADDHVTKPF
                     SLVLLVKRIKALIRRYYVIEDIWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLI
                     QHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL"
     gene            17451..18782
                     /gene="hk06"
                     /locus_tag="VVR18_001396"
     CDS             17451..18782
                     /gene="hk06"
                     /locus_tag="VVR18_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     HK06"
                     /protein_id="HEU6032902.1"
                     /translation="MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGE
                     KFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDG
                     KLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFS
                     YFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIHE
                     LESRNEQIVKLQNQKVSFVRGASHELKIPLASLRIILENMQHNIGDYKDHPKYIAKSI
                     NKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIENQLT
                     DATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEH
                     LFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISL"
     gene            18865..19392
                     /locus_tag="VVR18_001397"
     CDS             18865..19392
                     /locus_tag="VVR18_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenylcysteine carboxyl methyltransferase
                     family protein"
                     /protein_id="HEU6032903.1"
                     /translation="MVLAIILVTFFIRLIFLKRSIENEKRILSNGGKEFGVENTKRLT
                     MAHIVFYLSCLVEAMVHKTIFDGMGMVGLVLLIFSMLMLMLVIHLLGDIWTVKLMLVN
                     NHKYVDHILFRTVKHPNYFLNILPELIGLTLLSHAYVTFVLVFPVYAVILYRRIAEEE
                     KLLHEVIIPNGSIKR"
     gene            19471..>20858
                     /locus_tag="VVR18_001398"
     CDS             19471..>20858
                     /locus_tag="VVR18_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RICH domain-containing protein"
                     /protein_id="HEU6032904.1"
                     /translation="MFASKNERKVHYSIRKFSIGVASVAVASLFMGSVVHATENEGTT
                     QVATSSNKANKSQTEHMKAAKQVDEYIKKMLQLDRRKHTQNVGLLTKLGAIKTEYLHG
                     LSVSKEKSEAELPSKIKAELDAAFENFKKDTLKPGEKVAEAKKKVEEAELELVKEEAK
                     EPRDEEKIKQAKEKVESKKAEATRLENIKTDRKKAEEEAKRKADAKLKEANVATSDQG
                     NPKGRGKRGVPGELATPDKKENDAKSSDSSVGEETLPSSSLKSGKKVTEAEKKVEEAE
                     KKAKDQKEEDRRNYPTNTYKTLDLEIAESDVKVKEAELELVKEEAKEPRDEEKIKQAK
                     EKVESKKAEATRLEKIKTDRKKAEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPK
                     PEKPAEQPKAEKTDDQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKTGWKQEN
                     GMWYFYNTDGSMA"
BASE COUNT         6598 a         3420 c         4743 g         6097 t
ORIGIN      
        1 taaatagtaa gaaatatcta tcctatcttc tagaatgtct tccaaacgag gaaactctcg
       61 taaacaaaga ggttttagag gcctatttac catggactaa agttgtacaa gaaaagtgca
      121 aataagaaat ctccagatta ggaactatcc gtgagttctc tagtctggag atttttcaat
      181 atacttcgtt attggatggt tacaattcat aaagtgctgt agagagataa cgttcaccgt
      241 tatctggtgc tagggcaagg acttttttac ctgtacctaa ttttttggca acctcgatgg
      301 ctccgtagat agctgcagct gaggaaatcc ctacaaggaa gccttctttt ccaccaattt
      361 cacgtccgag tgcaagagcg tcatctgatg ttacacgaac gataccatca taggctttag
      421 tatcaagtgt atcaggaata aatccagctg agataccttg aattttgtga ggaccaggtt
      481 tttcaccaga tagaatagca gattcatctg cttctactgc aaaaacttga atgttagaat
      541 tttctgattt gagtgcatga gaaacaccag aaatcgttcc accggtacct actccagcaa
      601 caaaggcatc taatccatct ttaccgaaag cagctagtat ctcagctcct gttgttcttt
      661 cgtgtacttc tggattagct ggattgtcaa attgaagagg aaggaaacca tcacgttcag
      721 cagcgatttc ttgagcctta gcaatagcac ctttcattcc ctcgctacca ggagttagga
      781 cgagttcagc accataagct tggataattt tacgtcgttc tacactcata gtttcaggca
      841 taacgatgac gactttatac cctttagcag cacctaccca tgaaagtcca ataccagtgt
      901 ttccacttgt tgcttcaaca atagtagaac caggtttcag aataccatct tgttcagctt
      961 tttcaatcat gctaagggca atacggtctt ttacagatga accaggatta aatgcttcaa
     1021 gctttatata gacgtctgca gcaccttctg gcacgatgtt gttaagttta acaatcggtg
     1081 tttgaccgat taattcagta atgttgttat aaatagacat acgaatacct ctttgtataa
     1141 gatatcttta gtataacgct atccatacca tttgtaaaat atagaaatcc tatcgaagcg
     1201 ataggatttc tatatatcat agatcaaagt cattaatttt caagtgattg cgttcagcta
     1261 attctagtaa ataggtgtga aggaaaacga tatcaggttt cgtttgaatt gcttcatttt
     1321 ctagtatatt ttggtacgca tctttttatt ttgctcgcta aagtagttgt gagaatgtca
     1381 acgaaacgct gtattattca ttgtttacac taagtttaca ggaacttcaa cctctcgtaa
     1441 accttggtca gttaaagtga cttttccatt aaaaaactcc acaagtgcag ctttaatagt
     1501 ttctttttct tctttatcaa cataaatcat cgtatcgact tgatctgtaa agtttgtatc
     1561 cagctccatg agatcatgtt ctttaaggaa gttactgtac tcttggtact gagcataaga
     1621 catttgaata gcaatgccag cctgttcttt tatttcaata ataccaattt ctttgacagc
     1681 taaggcgaca ctgccggcgt aagcacgaat tagtcctcca gcgcctagtt taataccacc
     1741 aaagtagcgt gtcacgacca cacagacatt ggtgagattg tgattttcta gtaccccaag
     1801 catgggaaca ccagcagtac cactaggctc accatcatca cttgtacgtt taatttcact
     1861 acgttctcca ataataaagg cagagcagtt atgtgtcgct ttgtagtgtt cttttttgat
     1921 ggcagtaatg aagtcacgag cctcttcttc gctataaaca cgcttggcat ggcagataaa
     1981 gcgagatttt ttgatttctt cttggacttg gtcgtcctct ttaattgttc taaattccat
     2041 gatttaattg tactaaaaaa tcatctaaag tgctagtttt tacgaataaa gaagtatgaa
     2101 agtaaattta gattatctcg gtcgtttatt tactgagaat gaattaacag aagaagaacg
     2161 tcagttggcg gagaaacttc cagcaatgag aaaggagaag gggaaacttt tctgtcaacg
     2221 ttgtaatagt actattctag aagaatggta tttgcccatc ggtgcttact attgtcgaga
     2281 gtgcttgctg atgaagcgag tcagaagtga tcaaacttta tactattttc cgcaggagga
     2341 ttttccgaag caagatgttc tcaaatggcg cggccaatta actccttttc aagagaaggt
     2401 gtcagaggga ctgcttcaag cagtagacaa gcaaaagcca accttagttc atgcggtaac
     2461 aggagctgga aagacagaaa tgatttatca agtagtggct aaagtgatca atgcgggtgg
     2521 tgcagtgtgt ttggctagtc ctcgcataga tgtttgtttg gagctgtata agcgcctgca
     2581 acaggatttt tcttgcggga tagctttgct acatggagaa tcggaacctt attttcgaac
     2641 accactagtt gttgcaacaa cccatcagtt attgaagttt tatcaagctt ttgatttgct
     2701 gatagtggat gaagtagatg cttttcctta tgttgataat cccacgcttt accatgctgt
     2761 caagaatagt gtaaaggaga atggattgag aatcttttta acagcgactt cgaccaatga
     2821 gttagataaa aaggtccgtt taggagaact aaaaagactg aatttaccga gacggtttca
     2881 tggaaatccg ttgattattc caaaaccaat ttggttatcg gattttaatc gctacttaga
     2941 caagaatcgt ttgtcaccaa agttaaagtc ctatattgag aagcagagaa agacagctta
     3001 tccgttactc atttttgctt cagaaattaa gaaaggggag cagttagaag aaatcttaca
     3061 ggagcaattt ccaaatgaga aaattggctt tgtatcttct gtaacagagg atcgattaga
     3121 gcaagtacaa gcttttcgag atggagaact gacaatactt atcagtacga caatcttgga
     3181 gcgtggagtt accttccctt gtgtggatgt tttcgtagta gaggccaatc atcgtttgtt
     3241 taccaagtct agtttgattc agattggtgg acgagttgga cgaagcatgg atagaccgac
     3301 aggagatttg cttttcttcc atgatgggtt aaatgcttca atcaagaagg cgattaagga
     3361 aattcagatg atgaataagg aggctggtct atgaagtgct tgttatgtgg gcagactatg
     3421 aagactgttt taacttttag tagtctctta cttctgagga atgatgactc ttgtctttgt
     3481 tcagactgtg attctacttt tgaaagaatt ggggaagaga actgtccaaa ttgtatgaaa
     3541 acagagttgt caacaaagtg tcaagattgt caactttggt gtaaagaggg agttgaagtc
     3601 agtcatagag cgatttttac ttacaatcaa gctatgaagg attttttcag tcggtataag
     3661 tttgatggag acttcctgtt aagaaaagtt ttcgcttcat ttttaagtga ggagttgaaa
     3721 aagtacaaag agtatcaatt tgttgtaatt cccctaagtc ctgatagata tgctaataga
     3781 ggatttaatc aggttgaggg cttggtagag gcagcaggct ttgagtatct ggatttatta
     3841 gagaaaagag aagagagagc cagttcttct aaaaatcgtt cagagcgctt ggggacagaa
     3901 cttcctttct ttattaaaag tggagtcact attcctaaaa aaatcctact tatagatgat
     3961 atctatacta caggagcaac tataaatcgt gttaagaaac tgttggaaga agctggtgct
     4021 aaggatgtaa aaacattttc ccttgtaaga tgaggaaaaa tttgcaaaaa tagaatgaaa
     4081 gcgttataat aaaatcataa aaacaaaaat gtttagaaag aaggtactca tatgattaaa
     4141 tatagtatcc gtggtgaaaa cctagaagta acagaagcaa ttcgtgatta tgtagtttct
     4201 aaactcgaaa agatcgaaaa gtacttccaa ccagaacaag agttggatgc ccgaattaac
     4261 ttaaaagttt atcgtgaaaa aacggctaaa gtggaagtaa cgattccgct tggatctatt
     4321 actctccgcg cagaagatgt atctcaagat atgtatggtt caattgacct tgtaactgat
     4381 aaaattgaac gtcagattcg taaaaataaa acaaaaatcg agcgtaaaaa taaaaataag
     4441 gtagcaactg gtcaattatt tacagatgct ttggtggaag attcaaatgt tgtccagtct
     4501 aaagttgttc gtttaaaaca aattgattta aaaccaatgg atttggaaga agcaattcta
     4561 caaatggatt tattggggca tgatttcttt atctatgtgg atgttgaaga tcagataacc
     4621 aatgtgattt atcgtcgtga ggatggcgaa attggtttgt tagaggttaa agaatcttaa
     4681 tttcaatatg tgtaaaggta ggtttactga attgtaaact acctttttct tataattgat
     4741 agaattactg attacacttt taaaaagtcg ctttttgagg ggtattatgg tataatgggt
     4801 gccaagaggt tttgaatgaa aaaattttat gtaagtccaa tttttcctat tctagtagga
     4861 ttgattgcgt ttggagtctt atccactttc attatttttg ttaataataa tctgttgacg
     4921 gttttaattt tgtttctttt tgtaggaggc tatgtttttt tatttaagaa actgagagtg
     4981 cattatacaa ggagtgatgt agaacagata cagtatgtaa accaccaagc ggaagaaagt
     5041 ttgacatctc tattggaaca aatgcctgta ggtgttatga aattgaattt atcttctgga
     5101 gaggttgagt ggtttaatcc ctatgctgaa ttgattttga ccaaggaaga tggtgatttt
     5161 gatttagaag ctgttcaaac gattatcaag gcttcagtag gaaatccgtc tacttatgcc
     5221 aagcttggtg agaagcgtta tgctgttcat atggatgctt cttccggtgt tttgtatttt
     5281 gtagatgtat ccagggaaca agccataaca gatgaattgg taacaagtcg accagtgatt
     5341 gggattgtct ctgtggataa ttatgatgat ttggaggatg caacttctga gtcagatatt
     5401 agtcaaatca atagttttgt agctaatttt atatcagagt tttcagaaaa atacatgatg
     5461 ttttctcgtc gggtaagtat ggatcgattt tatctattta ctgactacac ggtgcttgag
     5521 ggcttgatga atgataaatt ttctgttatt gatgctttca gagaagagtc gaaacagaga
     5581 cagttgccct tgaccttaag tatgggattt tcttatggcg atggaaatca tgatgagata
     5641 gggaaagttg ctttgctcaa tttgaacttg gctgaagtac gtggtggcga ccaggtggtt
     5701 gttaaggaaa acgacgaaac gaaaaatcca gtttattttg gtggtgggtc tgctgcttca
     5761 atcaagcgta cacggactcg tacgcgcgct atgatgacag ctatttcaga taagattcgg
     5821 agtgtagatc aggtttttgt agtcggtcac aaaaatttag acatggatgc tttgggctct
     5881 gctgtaggta tgcagttgtt cgccagcaat gtgattgaaa atagctatgc tctttatgat
     5941 gaagaacaaa tgtctccaga tattgaacga gctgtttcat tcatagaaaa agaaggagtt
     6001 acgaagttgt tgtctgttaa ggatgcaatg gggatggtga ccaatcgttc tttgttgatt
     6061 cttgtagacc attcaaagac agccttaaca ttatcaaaag aattttatga tttatttacc
     6121 caaaccattg ttattgacca ccatagaagg gatcaggatt ttccagataa tgcggttatt
     6181 acttatatcg aaagtggtgc aagtagtgcc agtgagttgg taacggaatt gattcagttc
     6241 cagaattcta agaaaaatcg tttgagtcgt atgcaagcaa gtgttttgat ggctggtatg
     6301 atgttggata ctaaaaattt cacctcgcga gtaactagtc ggacatttga tgttgctagc
     6361 tatctcagaa cgcgcggaag tgatagtatt gctatccagg aaatcgctgc gacagatttt
     6421 gaagaatatc gtgaggtcaa tgaacttatt ttacaggggt gtaaattagg ttcagatgta
     6481 ctaatagcag aggctaagga cacgaaatgc tatgatacag ttgttattag taaggcagca
     6541 gatgccatgt tagccatgtc aggtattgaa gcgagttttg ttcttgcgaa gaatacacaa
     6601 ggatttatct ctatctcagc tcgaagtcgt agtaaactga atgtacaacg gattatggaa
     6661 gagttaggcg gtggaggcca ctttaatttg gcagcagctc aaattaaaga tgtaaccttg
     6721 tcagaagcag gtgaaaaact gatagaaatt gtattaaatg aaataaagga aaaggagaaa
     6781 gaagaatgaa agtaatcttt ttagcagatg ttaaaggaaa aggtaaaaaa ggcgaaatta
     6841 aggaagtacc aacagggtat gcgcaaaact ttcttatcaa aaagaatcta gccaaagaag
     6901 cgactgctca agctgtaggt gaacttcgtg gtaaacaaaa atcggaagaa aaagctcacg
     6961 ctgagatgat tgcagaagga aaagcaatta aagcacaact tgaagcagaa gaaactgttg
     7021 tagaatttgt tgaaaaagtt ggtccagatg gtcgtacctt tggttctatt accaataaga
     7081 agattgcaga agaattgcaa aagcaatttg gaattaagat tgataaacgt catattcaag
     7141 tacaagctcc gattcgagcg gttggtttga ttgatgtgcc agtgaaaatc tatcaagata
     7201 tcacaagtgt aatcaatctt cgtgtgaaag aaggataagt ttacactttc ttgacaagat
     7261 tgtaaaagaa gggaagtctg atggcagaag tagaagagtt acgagtacaa cctcaagata
     7321 tcttagctga gcaatccgtt ttaggggcta tctttattga tgagagtaaa cttgtttttg
     7381 tgcgagaata cattgagtct cgggactttt ttaagtatgc ccatcgtttg attttccaag
     7441 ccatggtcga tttatccgat cgtggtgatg ccatagatgc aacaacggtt cgtactatcc
     7501 ttgataatca aggtgattta cagaatattg gtggcttgtc ttacttggtt gagattgtta
     7561 attctgtgcc aacttctgct aatgcggagt attatgctaa gattgttgca gaaaaagcaa
     7621 tgctacgtcg tttaattgcc aagttgacag agtctgtcaa ccaagcttac gaagcgtcac
     7681 aaccagctga tgaaattatt gctcaggcag aaaaagggtt gattgatgtc agtgaaaatg
     7741 caaatcgaag cgggtttaag aacattcgag atgtgttgaa tctcaacttt ggaaatctgg
     7801 aagctcgctc gcaacaaacg accgatatta caggtattgc gacaggttat cgtgatttgg
     7861 atcatatgac aacaggactt catgaggagg agttgattat cttagcagct cgtccagcag
     7921 ttggtaagac agcatttgcc ttgaatatcg ctcagaacat tgggactaag ttggacaaaa
     7981 cggttgctat tttttcactc gaaatgggtg cggaaagctt ggtagatcgt atgttagctg
     8041 cagaaggctt ggtggagtca cattctatcc gtacagggca attgacagat gaggagtggc
     8101 aaaaatatac tattgctcag ggtaatctag ctaacgccag tatctatatc gatgatacgc
     8161 caggtattcg gattacagag attcgttctc gttctcgtaa attggctcaa gaaactggaa
     8221 atcttggttt gattttgata gactatttgc aacttatcac gggaactggt cgagaaaatc
     8281 gtcaacaaga agtttctgaa atttctcgtc agttgaaaat actagccaag gaattgaagg
     8341 ttccagtaat cgctctgagt cagctttctc gtggtgtaga acaacgtcag gacaagagac
     8401 cagtcttgtc tgatattcgt gaatctgggt ctattgagca ggacgctgat atcgtagctt
     8461 ttctctatcg cgatgactac tatgaacgtg gtggtgaaga agaggagggt atcccaaata
     8521 ataaggtgga agttattatc gagaaaaacc gtagtggagc tcgtggaaca gtggaattga
     8581 ttttccaaaa agaatacaat aaattttcaa gtatctcaaa gagggaggca taagatgtca
     8641 gatgcattta cagatgtagc caagatgaaa aaaatcaaag aagaaatcaa ggcacatgag
     8701 ggacaagtcg tagaaatgac tttggagaat ggtcgtaagc gccaaaaaaa tagattgggt
     8761 aagctaattg aagtttatcc atctctattt attgtggagt ttggggatgt ggaaggagat
     8821 aaacaagtta atgtttacgt tgaatccttt acttactcag atattcttac agaaaagaat
     8881 ttgattcatt atcttgacta aagtgagaaa ttttctcact ttttcttttt tctccgaata
     8941 atttaggtga aggcaatcat cgctttatat tatttttcaa ggaggaagaa tgaaaatttt
     9001 accgtttata gcaagaggaa caagttatta cttgaagatg tcagttaaaa agcttgttcc
     9061 ttttttagta gtaggattga tgctagcagc tggtgatagt gtctatgcct attccagagg
     9121 aaatggatcg attgcgcgtg gggatgatta tcctgcttat tataaaaatg ggagccagga
     9181 gattgatcag tggcgcatgt attctcgtca gtgtacttct tttgtagcct ttcgtttgag
     9241 taatgtcaat ggttttgaaa tgccggcagc ttatggaaat gcgaatgaat ggggacatcg
     9301 tgctcgtcgg gaaggttatc gtgtagataa tacaccgacg attggttcca ttacttggtc
     9361 tactgcagga acttatggtc atgttgcctg ggtgtcaaat gtaatgggag atcagattga
     9421 gattgaggaa tataactatg gttatacaga atcctataat aaacgagttg taaaagcaaa
     9481 cacgatgaca ggatttattc attttaaaga tttggatggt ggcagtgttg ggaatagtca
     9541 atcctcagct tcaacaggcg gaactcatta ttttaagacc aagtctgcta tcaaaactga
     9601 acccctagtt agtgcaactg tgattgatta ctattatcct ggggagaagg ttcattatga
     9661 tcagatactt gaaaaagacg gctacaagtg gttgagttat acggcttata acggaagtcg
     9721 tcgctatata cagctagagg gagtgacttc ttcacaaaat tatcagaatc aatcaggaaa
     9781 catctctagc tatggatccc atagtagttc aactgtcggt tggaagaaaa taaatggtag
     9841 ttggtatcat ttcaaatcaa atggttctaa atcaacagga tggctgaaag acggttctag
     9901 ctggtattat ttgaaattat ctggtgaaat gcagacagga tggttaaagg agaatggctc
     9961 gtggtattat ctgggtagtt caggggcaat gaaaacaggc tggtaccagg tctctggtaa
    10021 gtggtattat tcttactctt caggcgcctt agctgttaat acgacggtgg atggctacag
    10081 agtaaacagt gatggagaac gagtatagaa aattggagta ggagaaattt cctgctcttt
    10141 tctgtaagca gtttccttga catttttctt attttgcgct atcatatata catataatat
    10201 atgggagtct gtgtacagtc tgagaggaag tgttaaactt cgaccgcacc tgatctgggt
    10261 aatgccagcg gagggaacga tacttagtct aattttgcac cttttccatg tatggtaaag
    10321 gtttttcttt ttttaaaaag gaaaacgaga agaggaggtt cttatgaaag caagcattgc
    10381 cttgcaagtt ttacccctag tacaggggat tgatcggata gctgttattg atcaggtcat
    10441 tgcttatctg caaactcaag aagtgacgat ggtagtgaca ccatttgaaa cggtcttgga
    10501 aggggagttt gatgagctta tgcgcattct aaaagaagcg ctggaagtgg cagggcagga
    10561 ggcagacaat gtctttgcca atgtcaaaat aaatgtagga gagattttaa gtattgatga
    10621 gaaacttgag aagtatactg agacgacaca ttagtctatt gggctttctc ggagtattgt
    10681 caatctggca gttagcaggt tttcttaaac ttctccccaa gtttatcctg ccgacacctc
    10741 ttgaaattct ccagcccttt gttcgtgaca gagaatttct ctggcaccat agctgggcga
    10801 ccttgagagt ggctttactg gggctgattt tgggagtttt gattgcctgt cttatggctg
    10861 tgctcatgga tagtttgact tggctcaatg acctgattta ccctatgatg gtggtcattc
    10921 agaccattcc gaccattgcc atagctccta tcctggtctt gtggctaggt tatgggattt
    10981 tgcccaagat tgtcttgatt atcttaacaa caacctttcc catcatcgtt agtattttgg
    11041 acggttttag gcattgtgac aaggatatgc tgactttgtt tagtctgatg cgagcaaacc
    11101 cttggcaaat cctgtggcat tttaaaatcc cggttagcct gccttacttt tatgcaggtc
    11161 tgagggtcag tgtctcctac gcctttatca caactgtggt atctgagtgg ttgggaggtt
    11221 ttgaaggtct tggtgtttat atgattcagt ctaaaaaact gtttcagtat gataccatgt
    11281 ttgccattat tattctggtg tcgattatca gtcttttggg tatgaagctg gtcgatatca
    11341 gtgaaaaata tgtgattaaa tggaaacgta cttaaaatag agcgtttttg aaaaagaaaa
    11401 gaggaaatca aaatgaagaa aacatggaaa gtgtttttaa cgcttgtaac agctcttgta
    11461 gctgttgtgc ttgtggcctg tggtcaagga actgcttcta aagacaacaa agaggcagaa
    11521 cttaagaagg ttgactttat cctagactgg acaccaaata ccaaccacac agggctttat
    11581 gttgccaagg aaaaaggtta tttcaaagaa gctggagtgg atgttgattt gaaattgcca
    11641 ccagaagaaa gttcttctga cttggttatc aacggaaagg caccatttgc agtgtatttc
    11701 caagactaca tggctaagaa attggaaaaa ggagcaggaa tcactgccgt tgcagctatt
    11761 gttgaacaca atacatcagg aatcatctct cgtaaatctg ataatgtaag cagtccaaaa
    11821 gacttggttg gtaagaaata tgggacatgg aatgacccaa ctgaacttgc tatgttgaaa
    11881 accttggtag aatctcaagg tggagacttt gagaaggttg aaaaagtacc aaataacgac
    11941 tcaaactcaa tcacaccgat tgccaatggc gtctttgata ctgcttggat ttactacggt
    12001 tgggatggta tccttgctaa atctcaaggt gtagatgcta acttcatgta cttgaaagac
    12061 tatgtcaagg agtttgacta ctattcacca gttatcatcg caaacaacga ctatctgaaa
    12121 gataacaaag aagaagctcg caaagtcatc caagccatca aaaaaggcta ccaatatgcc
    12181 atggaacatc cagaagaagc tgcagatatt ctcatcaaga atgcacctga actcaaggaa
    12241 aaacgtgact ttgtcatcga atctcaaaaa tacttgtcaa aagaatacgc aagcgacaag
    12301 gaaaaatggg gtcaatttga cgcagctcgc tggaatgctt tctataaatg ggataaagaa
    12361 aatggtatcc ttaaagaaga cttgacagac aaaggcttca ccaacgaatt tgtgaaataa
    12421 tgacagaaat tagactagag cacgtcagtt atgcctatgg tcaggagagg attttagagg
    12481 atatcaacct acaggtgact tcaggcgaag tggtttccat cctaggccca agtggtgttg
    12541 gaaagaccac cctctttaat ctaatcgctg ggattttaga agttcagtca gggagaattg
    12601 tccttgatgg tgaagaaaat cccaaggggc gcgtgagtta tatgttgcaa aaggatctgc
    12661 tcttggagca caagacggtg cttggaaata tcattctgcc cctcttgatt caaaaggtgg
    12721 ataaggcaga agctatttcc cgagcggata aaattcttgc gaccttccag ctgacagctg
    12781 taagagacaa gtatcctcat gaacttagcg gtgggatgcg ccagcgtgta gccttactcc
    12841 ggacctacct ttttgggcac aagctctttc tcttagatga ggcctttagc gccttggatg
    12901 agatgacaaa gatggaactc cacgcttggt atcttgagat tcacaaacag ttgcagctaa
    12961 caaccctgat catcacgcat agtattgagg aggccctcaa tctcagcgac cgtatctata
    13021 tcttgaaaaa tcgccctggg cagattgttt cagaaattaa actagattgg tctgaagatg
    13081 aggacaagga agtccaaaag attgcctaca aacgtcaaat cttggcagaa ttaggcttag
    13141 ataagtagaa aaatagggag ttggtgaaga ttatccttta ccagcgccct ttttctttta
    13201 aaaatgagaa aatttcggta taatagtcaa acaaggtcaa ggtttaaaga gagaggtggg
    13261 tttgttatga gatttaaaaa tacatcggat catattgagg cctacatcaa ggcgatttta
    13321 gatcaatctg gtatcgtgga gttgcaacgg agtcagttgg cagatacctt tcaggttgtt
    13381 cctagtcaga ttaactacgt gatcaagaca cgctttacgg aaagtagagg ctacttggtt
    13441 gaaagtaagc gtggtggcgg aggctacatt cgtataggac ggattgagtt ttctagtcat
    13501 catgaaatgc tccgggagct gctttactcg attggtgagc gagtcagtca agaaatttat
    13561 gaggatattc tccagctttt ggttgagcag gaattgatga ccaagcagga gatgaatttg
    13621 ctagaatcag tagctttgga tcgcgtttta ggagaagaag ctccagttgt tcgagcaaac
    13681 atgctacgtc aggtcataca agaggtagat agaaaaggga agtaagatga actattcaaa
    13741 agcattgaat gaatgtatcg aaagtgccta catggttgct ggacattttg gagctcgtta
    13801 tctagagtcg tggcacttgt tgattgccat gtctaatcac agttatagtg tagcaggggc
    13861 aactttaaat gattatccgt atgagatgga ccgtttagaa gaggtggctt tggaactgac
    13921 tgaaacggac tatagccagg atgaaacctt tacggaattg ccgttctccc gtcgtttgca
    13981 ggttcttttt gacgaagcag agtatgtagc gtcagtggtc catgctaagg tgctagggac
    14041 agagcacgtc ctctatgcga ttttgcatga tggcaatgcc ttggcaactc gtatcttgga
    14101 gagggctggt ttttcttatg aagacaagaa agatcaggtc aagattgctg ctcttcgtcg
    14161 aaatttagaa gaacgggcag gctggactcg tgaagatctc aaggctttac gccaacgcca
    14221 tcgtacagta gctgacaagc aaaattctat ggcccatatg atgggcatgc cgcagactcc
    14281 tagtggtggt ctcgaggact atacgcatga tttgacagag caagcgcgtt ctggcaagtt
    14341 agaaccagtc atcggtcggg acaaggaaat ctcacgtatg attcaaatct tgagccgtaa
    14401 gactaagaac aaccctgtct tggttgggga tgctggtgtc gggaaaacag ctctggcgct
    14461 tggtcttgcc cagcgtattg ccagtggtga cgtgcctgcg gaaatggcta agatgcgcgt
    14521 gttagaactt gatttgatga atgtcgttgc agggacacgc ttccgtggtg actttgaaga
    14581 acgcatgaat aatatcatca aggatattga agaagatggc caagtcatcc tctttatcga
    14641 tgaactccac accatcatgg gttctggtag cgggattgat tcgactctgg atgcggccaa
    14701 tatcttgaaa ccagccttgg cgcgtggaac tttgagaacg gttggtgcca ccactcagga
    14761 agaatatcaa aaacatatcg aaaaagatgc ggcactttct cgtcgtttcg ctaaagtgac
    14821 gattgaagaa ccaagtgtgg cagatagtat gactatttta caaggtttga aggcgactta
    14881 tgagaaacat caccgtgtac aaatcacaga tgaagcggtt gaaacagcgg ttaagatggc
    14941 tcatcgttat ttaaccagtc gtcacttgcc agactctgct atcgacctct tggacgaagc
    15001 agcagcaaca gtgcaaaata aggcaaatca tgtaaaagca gacgattcag atttgagtcc
    15061 agctgacaag gccctgatgg atggcaagtg gaaacaggca gcccagctaa tcgcaaaaga
    15121 agaggaagta cctgtctaca aagacttggt gacagagtct gatattttga ccaccttgag
    15181 tcgcttgtca ggaatcccag ttcaaaaact gactcaaacg gatgctaaga agtatttaaa
    15241 tcttgaagca gaactccata aacgtgtcat cggtcaagat caagctgttt caagtattag
    15301 tcgtgccatt cgccgtaatc agtcaggaat tcgcagtcat aagcgtccga ttggttcctt
    15361 tatgttccta ggacctacag gtgtcgggaa aactgaatta gccaaggctc tggcagaagt
    15421 tctttttgac gacgaatcag cccttatccg ctttgatatg agtgagtata tggagaaatt
    15481 tgcagctagt cgtctcaacg gagctcctcc aggctatgta ggatatgaag aaggtgggga
    15541 gttgacagag aaggttcgca ataaacccta ttccgttctc ctctttgatg aggtagagaa
    15601 ggcccaccca gatatcttta atgttctctt gcaggttctg gatgacggtg tcttgacaga
    15661 tagcaaggga cgcaaggtcg atttttcaaa taccattatc attatgacat cgaatctagg
    15721 tgcgactgcc cttcgtgatg ataagactgt tggttttggg gctaaggata ttcgttttga
    15781 ccaggaaaat atggaaaaac gcatgtttga agaactgaaa aaagcttata gaccggaatt
    15841 catcaaccgt attgatgaga aggtggtctt ccatagccta tctagtgacc atatgcagga
    15901 agtggtgaag attatggtca agcctttagt ggcaagtttg gctgaaaaag gcattgactt
    15961 gaaattacaa gcttcagctc tgaaattgtt agcaaatcaa ggatatgacc cagagatggg
    16021 agctcgccca cttcgcagaa ccctgcaaac agaagtggag gacaagttgg cagaacttct
    16081 tcttaaggga gatttagtgg caggcagcac acttaagatt ggtgtcaaag caggccagtt
    16141 aaaatttgat attgcataaa agaataaaag tatcagcatc tgaccataag tcacagtgga
    16201 gtgaaactca atgaaaatca aagagcaaac taggcagcta gccgcaggtt gctcaaaaca
    16261 ctggtttgag gttgcagata gagctgacgt ggtttgaaga gattttcgaa gagtatgaaa
    16321 ctaaaaccta tagcttctaa acgatccgtg gttttcacca ttcaacacaa aattcatatg
    16381 tttattaccc tccgtcgtat ttgtcttaga gcgtgtgtag tagaaaaaga gcagtcttat
    16441 ctgaaatttt tattctttca aaagagacct gtttcttttt tgcatgtcaa atccgttcta
    16501 gctggtattt gaaaaatcaa actaatattc aataaaaatc aaagaacaaa ctaggaagct
    16561 agccgcaggt tgctcaaaac actgttttga ggttgtagat agagctgacg tagtttgaag
    16621 agattttcga agagtataag ctgcaagatg aatgattttc ttgtattgac gttgttgttg
    16681 acaaaaagta gcggataaat gaaatccatt ccattatcat agatgatagg ctggtaggaa
    16741 attttcaaat agcatacagg aaatagatgt atggagttct ggtagtagaa agggagagag
    16801 atgaacattt tagttgcaga tgacgaggaa atgattagag aaggaattgc agcatttctg
    16861 acagaagagg gttatcatgt cattatggct aaggatggac aagaggtctt ggaaaaattt
    16921 caagatctcc ctatccatct catgatattg gatttaatga tgcctaggaa gagtggtttt
    16981 gaagtgttaa aagaaatcaa tcaaaagcac gatattcctg tcatcgtctt gagtgctctg
    17041 ggagatgaaa ctactcagtc acaggtattt gatctctatg ctgatgatca tgtgacaaaa
    17101 cctttttctt tggtactgct tgtcaagcgt attaaggcgc ttatcagacg ttactacgtc
    17161 atagaggata tttggcgata tcaggatgta acagtggatt ttacctctta caaagcacat
    17221 tataaaaatg aagaaattga tctcaaacca aaggaattac tggtactaaa gtgtttgatt
    17281 cagcataaaa atcaagtttt aagtagagag cagatattgg aagaaatttc aaaagatgta
    17341 gctgatttac cttgtgatag ggtcgttgat gtctatattc gtactcttcg caaaaaatta
    17401 gctttagatt gtatcgtgac tgtgaaaaat gttggatata agattagctt atgataaaaa
    17461 atcctaaatt attaaccaag tcttttttaa gaagttttgc aattctaggt ggtgttggtc
    17521 tagtcattca tatagctatt tatttgacct ttccttttta ttatattcaa ctggaggggg
    17581 aaaagtttaa tgagagcgca agagtgttta cggagtattt aaagactaag acatctgatg
    17641 aaattccaag cttactccag tcttattcaa agtccttgac catatctgct caccttaaaa
    17701 gagatattgt agataagcgg ctccctcttg tgcatgactt ggatattaaa gatggaaagc
    17761 tatcaaatta tatcgtgatg ttagatatgt ctgttagtac agcagatggt aaacaggtaa
    17821 cagtgcaatt tgttcacggg gtggatgtct acaaagaagc aaagaatatt ttgcttttgt
    17881 atctcccata tacatttttg gttacaattg ctttttcctt tgttttttct tatttttata
    17941 ctaaacgctt gctcaatcct cttttttaca tttcagaagt gactagtaaa atgcaagatt
    18001 tggatgacaa tattcgtttt gatgaaagta ggaaagatga agttggtgaa gttggaaaac
    18061 agattaatgg tatgtatgag cacttgttga aggttattca tgagttggaa agtcgtaatg
    18121 agcaaattgt aaaattgcaa aatcaaaagg tttcctttgt ccgcggagca tcacatgagt
    18181 tgaaaatccc tttagccagt cttagaatta tcctagagaa tatgcagcat aatattggag
    18241 attacaaaga tcatccaaaa tatattgcaa agagtataaa taagattgac cagatgagcc
    18301 acttattgga agaagtactg gagtcttcta aattccaaga gtggacagag tgtcgtgaga
    18361 ccttgactgt taagccagtt ttagtagata ttttatcacg ttatcaagaa ttagctcatt
    18421 caataggtgt tacaattgaa aatcaattga cagatgctac cagggtcgtc atgagtctta
    18481 gggcattgga taaggttttg acaaacctga ttagtaatgc aattaaatat tcagataaaa
    18541 atgggcgcgt aatcatatcc gagcaagatg gctatctctc tatcaaaaat acatgtgcgc
    18601 ctctaagtga ccaagaacta gaacatttat ttgatatatt ctatcattct caaatcgtga
    18661 cagataagga tgaaagttcc ggtttgggtc tttacattgt gaataatatt ttagaaagct
    18721 atcaaatgga ttatagtttt ctcccttatg aacacggtat ggaatttaag attagcttgt
    18781 agacagatta gttttttatt aaagttcata tagggttaac ataagtgtgt tattctttgt
    18841 atagataaaa gaaaggatac taatatggta ttagcgatta ttttagtaac attctttatt
    18901 cgattgattt ttttaaagcg ttcgatagag aatgagaaac gaatccttag caatggcggg
    18961 aaagaatttg gagttgagaa tacaaaacga ttaactatgg ctcatattgt tttttatctc
    19021 tcttgcttgg ttgaggcaat ggtgcacaag acaatttttg atggcatggg tatggttggt
    19081 ttagtcttgc ttattttttc tatgctgatg ttaatgttgg tgattcactt gttgggagat
    19141 atttggacag tgaagcttat gcttgtcaat aatcacaaat atgtagatca tatcttgttt
    19201 aggacagtaa aacatcctaa ttacttttta aatattcttc ctgagttgat tggcttgacc
    19261 ttgttgagtc atgcttatgt gacttttgtt ttagtttttc cagtttatgc agttattttg
    19321 tatcgacgaa tagctgaaga ggaaaagcta ttacatgaag ttataatccc aaatggaagc
    19381 ataaagagat aaatacaaaa ttcgatttat atacagttca tattgaagtg atatagtaag
    19441 gttaaagaaa aaatatagaa ggaaataaac atgtttgcat caaaaaacga aagaaaagta
    19501 cattattcaa ttcgtaaatt tagtattgga gtagctagtg tagctgttgc cagtcttttt
    19561 atgggaagtg tggttcatgc gacagagaac gagggaacta cccaagtagc cacttcttct
    19621 aataaggcaa ataaaagtca gacagaacat atgaaagctg ctaaacaagt cgatgaatat
    19681 ataaaaaaaa tgctccaatt agatagaaga aaacataccc aaaatgtcgg cttactcaca
    19741 aagttgggcg caattaaaac ggagtatttg catggattaa gtgtttcaaa agagaagtcg
    19801 gaagctgagt tgccgtcaaa aataaaagca gagttagacg cagcttttga gaactttaaa
    19861 aaagatacat tgaaaccagg agaaaaggta gcagaagcta agaagaaggt tgaagaagcg
    19921 gagcttgaac tagtaaaaga ggaagctaag gaacctcgag acgaggaaaa aattaagcaa
    19981 gcaaaagaga aagttgagag taaaaaagct gaggctacaa ggctagaaaa catcaagaca
    20041 gatcgtaaaa aagcagaaga agaagctaaa cgaaaagcag atgctaagtt gaaggaagct
    20101 aatgtagcga cttcagatca aggtaaccca aaggggcggg gaaaacgagg agttcctgga
    20161 gagctagcaa cacctgataa aaaagaaaat gatgcgaagt cttcagattc tagcgtaggt
    20221 gaagaaactc ttccaagctc atccctgaaa tcaggaaaaa aggtaacaga agctgagaag
    20281 aaggttgaag aagctgagaa aaaagccaag gatcaaaaag aagaagatcg ccgtaactac
    20341 ccaaccaata cttacaaaac gcttgacctt gaaattgctg agtccgatgt gaaagttaaa
    20401 gaagcggagc ttgaactagt aaaagaggaa gctaaggaac ctcgagacga ggaaaaaatt
    20461 aagcaagcaa aagagaaagt tgagagtaaa aaagctgagg ctacaaggtt agaaaaaatc
    20521 aagacagatc gtaaaaaagc agaagaagct aaacgaaaag cagcagaaga agataaagtt
    20581 aaagaaaaac cagctgaaca accacaacca gcgccggctc ctcaaccaga aaaaccagct
    20641 ccaaaaccag agaagccagc tgaacaacca aaagcagaaa aaacagatga tcaacaagct
    20701 gaagaagact atgctcgtag atcagaagaa gaatataatc gcttgactca acagcaaccg
    20761 ccaaaaactg aaaaaccagc acaaccatct actccaaaaa caggctggaa acaagaaaac
    20821 ggtatgtggt acttctacaa tactgatggt tcaatggc
//
LOCUS       DAVHSO010000038        20650 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.038, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000038 DAVHSO010000000
VERSION     DAVHSO010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20650)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20650)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20650
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.038"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(358..1965)
                     /locus_tag="VVR18_001399"
     CDS             complement(358..1965)
                     /locus_tag="VVR18_001399"
                     /EC_number="6.3.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CTP synthase"
                     /protein_id="HEU6032905.1"
                     /translation="MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPY
                     INIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRK
                     ERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
                     QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPA
                     GQGIKNKLAQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMT
                     EWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVNDVEVKINWVNAND
                     VTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEF
                     ARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAA
                     YHNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQY
                     HPELSSRPNRPEELYTAFVTAAVENSN"
     gene            complement(2355..2942)
                     /locus_tag="VVR18_001400"
     CDS             complement(2355..2942)
                     /locus_tag="VVR18_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="HEU6032906.1"
                     /translation="MELEVFAGQEKSELSMIEVARAILELRGRDHEMHFSDLVNEIQN
                     YLGTSNSDIREALPLFYTELNFDGSFISLGDNKWGLRSWYGVDEIDEEIIALEENDDD
                     EVAPKAKKKRVNAFMDGDSDAIDYNADDPEDEDAYEADPALSYDDENPDDEKNEVEAY
                     DAEINEIAPDDLGEDVDLNEDDDEFSDDDAETSEE"
     gene            complement(3070..3519)
                     /locus_tag="VVR18_001401"
     CDS             complement(3070..3519)
                     /locus_tag="VVR18_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6032907.1"
                     /translation="MCFVPYYKVNHCEEAFAWYQDVNLVYLVDGVKLPYSQATLEAMY
                     SYLDWHGELFWIEVKEKGEWFPIGDITLSQDNLPIVIGNSAYQHRGLGKKILSALIEL
                     ARVKGWKELRVKEIYTYNHASRRCFKSLGFVENGATEKGRSFILELV"
     gene            complement(3524..3912)
                     /locus_tag="VVR18_001402"
                     /pseudo
     CDS             complement(3524..3912)
                     /locus_tag="VVR18_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867286.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome partitioning protein ParB"
     gene            complement(3939..4565)
                     /locus_tag="VVR18_001403"
     CDS             complement(3939..4565)
                     /locus_tag="VVR18_001403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEU6032908.1"
                     /translation="MKGSFALLLFVILGYMVKFYPEMLVNFDQSIQTAIRGDLPDYLT
                     ILFRALTRLIDIPVIITWVVITAFVFYRKRWKIESFFMLGNLALAGLLIVTFKNIYQR
                     PRPAILHLVEEKGFSFPSGHSLAVTLMVGTLIVILSQRIKDQVWRKIVQIVLGLYLVS
                     VLVSRVYLGVHYPSDVLASLCVGLGVLFIEFPFYDKLRFQWRFKGKQK"
     gene            complement(4579..5142)
                     /locus_tag="VVR18_001404"
     CDS             complement(4579..5142)
                     /locus_tag="VVR18_001404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU6032909.1"
                     /translation="MTNTRRLSTIAILSAISFVLMYFDFPLLPAASFLKIEFSILPVL
                     VGLVVMDLPAALGVLLLRSLLKLLLNSQGVNTYIGLPMNIVALGVFVIVFALIWKKER
                     TTLRFLLGSLAGTIGLTLAMLVLNYVYAVPLYAKFANFDIGKILGLSNYLMTMVLPFN
                     LIEGVIFSVSFWLLYVLLKPTLKHYER"
     regulatory      complement(5307..5541)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            complement(5595..6098)
                     /locus_tag="VVR18_001405"
     CDS             complement(5595..6098)
                     /locus_tag="VVR18_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (cytidine(34)-2'-O)-methyltransferase"
                     /protein_id="HEU6032910.1"
                     /translation="MTNHIVLFEPQIPQNTGNIARTCAATNSPLHIIKPMGFPIDDRK
                     MKRAGLDYWDKLEIYFYESLEDFISQMKGKLYLISKFAEKVYSEVDLSTDEDHYFLFG
                     REDKGLPEDFMREHPEKALRIPMNDEHVRSLNVSNTVCMIVYEALRQQNFAGLELVHT
                     YEVDKLK"
     gene            complement(6291..7121)
                     /locus_tag="VVR18_001406"
     CDS             complement(6291..7121)
                     /locus_tag="VVR18_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU6032911.1"
                     /translation="MQAKLIGYQHRDTVIHRLSGAGKLLFFILVSLAAMISYDTRMLL
                     LIAIFSVFLLYLSEIRFKDVSFVAVFATVFAVLNVLMVYLFSPEYGVGLYGERSVIWQ
                     GIGVYTLTSQELFYLLNLAIKYLCTIPLAIIFLMTTHPSQFASSLNQIGVPYKIAYSV
                     SLTLRYIPDLQEEFFTIKMSQEARGMELSKKASLMQRIKGNLLIITPLIFSSLERIDT
                     IATAMELRRFGKEKKRTWYSYQALKKGDYITLLLATLFLVVSLLLILQNQGRFYNPWK
                     "
     gene            complement(7106..8788)
                     /locus_tag="VVR18_001407"
     CDS             complement(7106..8788)
                     /locus_tag="VVR18_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000656554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6032912.1"
                     /translation="MKEAIIEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGS
                     GKSTLGQCLNGIIPNIYKGQTYGEFLIKGQVAFDMSIYDKSHLVSTVLQDTDGQFIGL
                     SVAEDLAFALENDVTALDEMKGRVYKWAEKLDLLPLLDQRPQDLSGGQKQRVSLAGVL
                     IDESPILLFDEPLANLDPKSGQDIIELIDQIHKEEGTTTLIIEHRLEDVLHRPVDRIV
                     LINDGRILFNGSPDQLLATDLLTQNGIREPLYLTTLRQLGVDLVKEEQLANLDNMSIS
                     KGQVQLQNELAKETPELQSLFKLEDVSFSYDDRPILKSLHLDIKKGEKIAIVGKNGAG
                     KSTLAKALSSFIQTEGRYLWEGQDIKGDSVAERAERVGYVLQNPNQMISTNMIFDEVA
                     LGLRLRGVDEQEIETRVYETLKICGLYEFRNWPISALSFGQKKRVTIASILVLGAEII
                     LLDEPTAGQDQKNYTEIMEFLEELHQQGHTIVMITHDMQLMLDYSDRVLVMVDGELIA
                     DTVPASLLSDPELLVKANLKETSIFNLAKKLDVDPLDLTAFYKERREGCKLN"
     gene            complement(8890..9192)
                     /locus_tag="VVR18_001408"
     CDS             complement(8890..9192)
                     /locus_tag="VVR18_001408"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032913.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEIVDRTDEVSSKHGFEVVDETDEVS
                     SKHGFEVVDETDEVSNHTYGKAKLTWFEEIFEEYKMMGKAGQLVFFDVYRLVRQVS"
     gene            complement(9199..9747)
                     /locus_tag="VVR18_001409"
     CDS             complement(9199..9747)
                     /locus_tag="VVR18_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF-type riboflavin transporter
                     substrate-binding protein"
                     /protein_id="HEU6032914.1"
                     /translation="MEIKFTIKQVVAVGIGAALFVVIGMINIPTPVPNTSIQLQYAVQ
                     ALLSIIFGPIIGLLVGLIGHAIKDSLVGYGLWWTWIIASGLFGLVVGLFRKYVRVINS
                     VFDWKDILIFNLIQLLANALVWGVLAPLGDVVIYQEAAEKVFAQGIVAGIANGVSVAI
                     AGTLLLLAYAGTQTRAGSLKKD"
     gene            complement(9762..10610)
                     /locus_tag="VVR18_001410"
     CDS             complement(9762..10610)
                     /locus_tag="VVR18_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosyl-l-methionine hydroxide
                     adenosyltransferase family protein"
                     /protein_id="HEU6032915.1"
                     /translation="MNNNLLVLQSDFGLVDGAVSAMIGVALEESPTLKIHHLTHDITP
                     YNIFEGSYRLFQTVDYWPEGTTFVSVVDPGVGSKRKSVVAKTAKNQYIVTPDNGTLSF
                     IKKHVGIVAIREISEVANRRQNTEHSYTFHGRDVYAYTGAKLASGHITFEEVGPELSV
                     EQIVELPVVATIIEDHLVKGAIDILDVRFGSLWTSITREEFYKLEPEFGDRFEVTIYH
                     ADMLVYQNQVVYGKSFADVRIGQPILYINSLYRLGLAINQGSFAKAYNVGVGSSWTIE
                     IKKIEG"
     gene            10799..12148
                     /gene="trkA"
                     /locus_tag="VVR18_001411"
     CDS             10799..12148
                     /gene="trkA"
                     /locus_tag="VVR18_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk system potassium transporter TrkA"
                     /protein_id="HEU6032916.1"
                     /translation="MKIILVGGGKVGFALCRSLVAEKHDVLLIEQDEAVLNHIVSRFD
                     IIGILGNGADFAILEQASVQDCDIFIALTEHDEVNMIAAVLAKKMGAKETIVRVRNPE
                     YSNSYFKEKNILGFSLIVNPELLAARAIANIIDFPNALSVERFAGGRVSLMEFVVKST
                     SGLCQMPISDFRKKFGNVIVCAIERDHQIIIPSGDMTVQDKDRIFVTGNRVDMILFHN
                     YFKSRAVKSLLIVGAGRIAYYLLGILKDSRIDTKVIEINPEIASFFSEKFPNLYIVQG
                     DGTAKDILLEESAQHYDAVATLTGVDEENLITSMFLDRVGVQKNITKVNRTSLLEIIN
                     APDFSSIITPKSIAVDTIMHFIRGRVNAQYSDLQAMHHLANGQIETLQFHIKEANKMT
                     AKPLSQLKLKKEVLIAAIIRKGKTIFPTGEDMLEVGDKLLVTTLLPNITKIYDLIAR"
     gene            12152..13591
                     /locus_tag="VVR18_001412"
     CDS             12152..13591
                     /locus_tag="VVR18_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEU6032917.1"
                     /translation="MNKSMIRYLLSKLLLIEAVLLLVPVAIAVYYRESSQVFTALFST
                     IGILVLLGGSGSLQKPKNQRIYAKEGVLIVALCWILWSFFGGLPFVFSGQIPSLIDAF
                     FEISSGFTTTGASILNDVSVLSRSLLFWRSFTHLIGGMGVLVFALAIMDNAKNSHLEV
                     MKAEVPGPVFGKVVSKLKNTAQILYLLYLALFSLFVIIYYLAGMPLYDSFVIAMGTAG
                     TGGFTVYNDGIAHYGSSLITYLVSIGVLVFGVNFNLYYYLMLRRIKAFFGDEELRAYL
                     VIVLVSTGLISLNTLYLYPGFSKSFEMTFFQVSNIITTTGFGYGDITNWPLFSQFILL
                     FLMAIGGSAGSTAGGLKIIRGLILSKIAKNQILSILSPHRVLTLHVNQTVIDKDTQHK
                     ILKYFVIYAMILLALIFIVSLDSNDFLVVTSAVFSCFNNIGPILGTTSSFSIFSPISK
                     ILLSFAMIAGRLEIYPILLLFMKRTWSKR"
     gene            complement(13717..15396)
                     /locus_tag="VVR18_001413"
     CDS             complement(13717..15396)
                     /locus_tag="VVR18_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEU6032918.1"
                     /translation="MDKLVAAIEKQQGKFEKISTNNYMMAIKDGFIATMPLIMFSSFL
                     MIIIMIPKNFGVELPSPAIAWMRKVYMLTMGVLGVIVSGTVAKSLAGNVNRKMPPGKV
                     INDTSAMLAAICGYLVLTVTLVVDEKTGSTSLSTNYLGSQGLITSFVSAFITVNVYRF
                     CIKRDITIHLPKEVPGAISQAFRDIFPFSFVLLISGLLDIVSRFSLDVPFAQVFQQLL
                     TPIFKGAESYPAMMLIWFMCALLWFVGIHGPSIVLPAVTALQLSNMEENAQLLANGQF
                     PYHSLTPNFGNYIAAIGGTGATFVVPFILIFFMRSKQLKSVGKATITPVLFAVNEPLL
                     FGMPVILNPYLFVPFLMTPPVNVFLGKVFIDFFGMNGFYIQLPWAFPGPLGLLIGTNF
                     QSISFVFLSLILVVDILIYLPFCRAYDRQLLMKEDVASSNDIILEEETSEIMPGELDE
                     IKSKELKVLVLCAGSGTSAQLANAINEGAQLAEVRVIANSGAYGAHYDIMGVYDLIIL
                     APQVRSYYREMKVDAERLGIQIVATRGMEYIHLTKSPSKSLQFVLEHYQAV"
     gene            complement(15466..16878)
                     /gene="lacG"
                     /locus_tag="VVR18_001414"
     CDS             complement(15466..16878)
                     /gene="lacG"
                     /locus_tag="VVR18_001414"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEU6032919.1"
                     /translation="MENLQFKALPKEFLLGAATAAYQVEGATRVDGKGINMWDVYLQE
                     NSPFLPDPASDFYYRYEEDIALAAEHGLQALRLSISWVRIFPDIDGEPNILAVRYYHR
                     VFQSCLKHNVIPFVSLHHFDSPQKMLETGDWLNRENIDRFIRYARFCFQEFTEVKHWF
                     TINELMSLAAGQYIGGQFPPNHHFQLSEAIQANHNMLLAHALAVLEFHQLGIEGEIGC
                     IHALKPGYPIDGQKENILAAKRYDVYNNKFLLDGTFLGYYSDDTLFHLNQILEANNSS
                     FIIEDGDLEIMKRAAPLNTMFGMNYYRSEFIREYKGENRQEFNSTGIKGQSSFKLNAL
                     GEFVKKPGIPTTDWDWNIYPQGLFDMLLRIKEEYPQHPVIYLTENGTALKEVKPEGEN
                     DIIDDSKRIRYIEQHLHKVLEARDRGVNIQGYFIWSLQDQFSWANGYNKRYGLFFVDY
                     ETQKRYIKKSALWVKGLKRN"
     gene            complement(16888..17232)
                     /locus_tag="VVR18_001415"
     CDS             complement(16888..17232)
                     /locus_tag="VVR18_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU6032920.1"
                     /translation="MKSKEEINMLGFTIVAYAGDARSDLMDALAFARDGYFEQARELV
                     ESANDSIVSAHREQTNLLAEEAYGDNFEVSFIMIHGQDTLMTTMLLYDQVKFFIDEYE
                     RIRKIEEHIGLQ"
     gene            complement(17400..19286)
                     /locus_tag="VVR18_001416"
     CDS             complement(17400..19286)
                     /locus_tag="VVR18_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000236922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4838 domain-containing protein"
                     /protein_id="HEU6032921.1"
                     /translation="MVIRVFDKQKNTYSSFALEELSYYINRVFKTDIELVEEKEADIF
                     VGLVNKEDRRDHVLISLDKGKGRIESNTIVGLLIGIYRMFHEFGVVYTRPGHRHDFVP
                     ELRFEDFLDKQLSIDETASYYHRGVCIEGADSFENILDFIDWLPKIGMNSFFIQFENP
                     YSFLKRWYEHEFNPYLNKEKFSNELVQELSDRLDKELQKRGLIHHRVGHGWTGEVLGY
                     SSKFGWESGLSISEEKKPYVAEINGKRELFNTAPILTSLDFSNPDVADKMVEIIKDYA
                     KKRPDVNYLHVWLSDARNNICECENCRQELVSDQYIRILNQLDRALTSEGLDTKICFL
                     LYHELLWAPQKEKLDNPERFTMMFAPITRTFEMSYADVDFDNSIPTPKPYLRNKIILP
                     NSLEENLSYLFEWQKTFKGDSFVYDYPLGRAHYGDLGYMKISQTIYRDVSYLSNLHLN
                     GYISCQELRAGFPHNFPNYVMGEMLWKKTRSYEELIEEYFSALYGSNWQSVVEYLEKL
                     SSYSSCDYFNAIGSRQNDVLANHYYIAYNLADNFLPIIEENISKLLNSQKDEWKQLSY
                     HREYVVKMAKALYLQATGKTRQAQDEWRNVLNYIRGHELLFQSNLDVYRVIEVAKNYA
                     GFHL"
     gene            complement(19288..20610)
                     /locus_tag="VVR18_001417"
     CDS             complement(19288..20610)
                     /locus_tag="VVR18_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEU6032922.1"
                     /translation="MNNILTFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSL
                     FLILISWPQEDFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPS
                     AGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAE
                     IYRMFIQRGITIKMPSGVPDVVSKSFSALLPGFTTFVLWALVLKGLEAAGVAGGLNGL
                     LGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEA
                     VAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFN
                     INTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIG
                     GFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK"
BASE COUNT         6382 a         4611 c         3550 g         6107 t
ORIGIN      
        1 tggattaaat taaaaaagta taatgtattg aatctataac agtacatctt gactgctaaa
       61 atatttctat aaattaattt gacttttctg atagagatgt tcacatctta tttcaattca
      121 ctatacaatc cagttcctaa aactttgcta gaaattgatt tggctttccg aattaatttg
      181 ttcagatttt atttcatttc aatatactga taaatccatt cactagcaca gggcaagagg
      241 gagtcgctat taatttcaac ggtagcaggt acatacagag gactcctacc tcagatatac
      301 tgcaatatca ttgtatgcaa aaaacctctg agatttttct caaaggttct gattttgcta
      361 attgctgttc tcaaccgctg cagtaacaaa ggcagtgtag agttcttctg gtcggtttgg
      421 acggcttgac agttcagggt gatactgaca agctacaaag aatttatttt caggaatttc
      481 cacgatttct accaaacgat tgtctggaga aactcctgaa aagacaaaac ctgctgcctc
      541 aaactgctca cggaaggcat tattaaactc ataacggtga cggtgacggc gttgcaccac
      601 ttcttgattg tgataagcag cagcagcctt agagccacgt ttcaacttag acggataaag
      661 tcccaaacga agggttccac ccatatcctc aatatcaatc tgatcacgca tgatatcaat
      721 gatagggtat tttgtttctg gtgcaagctc tgcagaattg gcaccttcaa gacctaaaac
      781 gtgacgagca aactcgatac atgtcaactg cattcccaag cagactccca acattggaac
      841 atcattttca cgcgcatagc ggatggcttg gattttccct tctgtaccac gttgaccaaa
      901 accacctggt acgatgatcc cgtccgcatc agacaagagt tctgctacat tctctgctgt
      961 cacatcattg gcattgaccc aattgatttt aacttctaca tcattgacat agccagagtg
     1021 tttcaaggct tcgaccactg agatataggc atcttgcaac tccacatact taccaacaag
     1081 ggaaatctta acttgtttct tgaggttcat gaccttgtcc accatggctg accattctgt
     1141 catatccgct gctggtgcgt ctaatttcaa atgatcacaa acaatttggt ccatcccttg
     1201 tgcctgcaag ttcagtggaa tttggtaaag gtgttcaaca tccaacgatt cgataacggc
     1261 ttctggtgcc acatcacaga actgggccag tttattttta attccttgac cagctggctc
     1321 ttctgtacga ataaccaaca tatttggttg gattcccaag ccacgcaatt ctttgacaga
     1381 gtgttgggtt ggtttggttt tcatttcacc agcagccttg aggtaaggaa gcaaggttgt
     1441 atggatatac atgacattat ccgcacccac atctgccttc atctgacgaa gagcctctag
     1501 gaatggcaag gactcgatat ctcctactgt tccaccaacc tctgtgataa tgacatcaga
     1561 gtcggtcgtt agagcggcac gcttgatttt ttctttcaaa gcatctgtga tatgaggaat
     1621 gacttgaaca gttgccccaa ggtattctcc acggcgttct ttacgaagaa cttcactgta
     1681 aattttccca gttgtcacgt tggaatattt gttgagattg atatcgatga aacgttcata
     1741 gtgacccaag tccaaatctg tctcagctcc gtcatctgtc acaaaaactt ccccgtgctg
     1801 gtaaggactc atggttcccg gatcaatatt gatataaggg tcaaactttt gaatggttac
     1861 tttgagacca cgatttttca agagacggcc tagactcgct gccacaatcc ctttcccaat
     1921 agacgatacc acaccaccag ttacaaaaat atatttcgta gacatagatt cctctttcta
     1981 aaatgctcaa ggtcttgtta actacgaggg gatatagaaa acaagaccct actaataaga
     2041 ataatctggg acgactgcac cagattcaca actaatactc ttcgaaaatc tcttcaaacc
     2101 gcgtcaacgt cgccttgccg tagatatgtg ttcctgactt tgtcagtctt atctacaacc
     2161 tcaaaacagt gttttgagca gcctacggct agtttcctag cttgctcttt gattttcatt
     2221 gagtataaaa tacaagaaga taacttcttg aaaaaacaaa aatagctccc taagaactag
     2281 ggagccccga cctctaaaag aggtgcccaa acaatatgat acctaaaaat aggataattg
     2341 tcaatagcta actcttattc ctcgctggtt tcagcgtcgt catctgaaaa ctcgtcgtcg
     2401 tcttcgttga gatccacatc ttctcccaag tcatctggag cgatttcgtt gatttctgca
     2461 tcataagctt ccacttcatt tttttcatca tctggatttt catcatcgta tgaaagagct
     2521 ggatctgctt cgtatgcatc ttcgtcttct ggatcatctg cattgtagtc aatggcatct
     2581 gaatcaccat ccataaaggc attgacacgt tttttcttag cttttggtgc tacttcatcg
     2641 tcgtcatttt cttcaagagc gatgatttct tcgtcgattt cgtccacacc ataccatgaa
     2701 cgaagacccc atttgttgtc cccaagtgag atgaagctac cgtcaaagtt caactctgtg
     2761 tagaacaaag gcaaagcttc gcggatatcg ctgtttgatg ttccaaggta gttttgaatt
     2821 tcgtttacaa gatcgctaaa atgcatctca tgatcgcgac cacgaagttc taagatagca
     2881 cgcgctacct caatcataga tagttcactt ttttcttgcc cagcaaatac ttctaattcc
     2941 aaagcgtttc tcctcattta tactactatc gtcagagcga acagactctg acctcatttt
     3001 atcatttact ctttatttta cgataatttt gcggaatagt caaaggttaa gggggagaaa
     3061 gtggcaggat tagactaatt ccaatataaa actccttcct ttttctgttg ctccattttc
     3121 cacaaatcca agcgacttga aacacctcct agaagcatga ttgtaggtgt agatttcctt
     3181 gactctcaat tctttccatc cttttactcg agccaattca atcaaagcac ttagaatctt
     3241 ttttccaagt cctcgatgtt ggtaagcgga attcccaatc acaatgggga gattatcctg
     3301 agatagtgta atatccccaa ttggaaacca ttctcccttc tccttgactt caatccaaaa
     3361 aagctcacca tgccaatcca aataggaata catggcttcc aaggtcgctt gactgtaagg
     3421 aagcttcacc ccatctacga ggtaaaccaa gttcacatcc tgataccaag caaaagcttc
     3481 ctcacaatga ttgaccttat aataaggaac aaaacacaat gcactacctt ttcaacaaaa
     3541 gagttgctgc ttgattaaaa ccatcacacc agttatacca tttgcttcat acccatcttg
     3601 agctaggata cgatctttta aatcaaaaac agagtaaatc tttctttcct cgcaagcttg
     3661 cgcatagaga tgatatagtt catcaccacc atctctatcc cactcagcag aaatcgtatc
     3721 ccgacctgcc aataaaacct gataagccct gtgatgccca tctgtaatca gcaaacaatc
     3781 tccaaaggca agaatactga ttcgatcgac ttggattgtt tctgccgact ggtaaagcat
     3841 ctgaatatct tgcaacttct tttctgataa atatagttga gtcggatgaa gatctgctat
     3901 attgactttc atttctttct ctcaagggaa ttcgatactc acttctgttt gcctttaaat
     3961 cgccattgga agcggagctt gtcataaaag ggaaactcga taaacaggac tcccaagccc
     4021 acacagagac tggcaaggac gtctgatggg taatgaactc ccagatagac tcttgatacc
     4081 agcacactga ctaggtagag gccaaggacg atttgtacga tttttctcca gacctgatct
     4141 ttaatccgct gactaagaat aacaatcaaa gtccctacca tcagcgttac agctagagaa
     4201 tgcccacttg ggaaggaaaa tcccttctcc tccaccagat gtaaaatagc tggtcgtggg
     4261 cgctggtaga tatttttaaa ggtcacgatt aaaagacctg ccaaagccag atttcccagc
     4321 atgaagaaac tttctatctt ccatcgctta cgataaaaga caaaagctgt aatgacaacc
     4381 caagtgataa tcactgggat atcaatcaga cgtgtgaggg ctcgaaaaag aatagtcaaa
     4441 taatctggta agtctcctcg aatggcagtc tgaatcgatt ggtcaaaatt gaccaacatt
     4501 tcagggtaaa atttgaccat atagccaaga ataacgaaaa gtaaaagggc aaaactgccc
     4561 ttcattaaaa atgtttgttt atctttcata gtgttttaag gttggtttca aaaggacgta
     4621 caacaaccag aatgaaacgg aaaagattac accctcaatc aagttaaaag gtaataccat
     4681 ggtcattagg tagttggaaa gtcccaaaat ttttccaata tcaaagttag caaacttagc
     4741 gtacaaagga acagcataaa catagttgag aaccaacatg gccaaggtta aaccaatagt
     4801 tccagctaga gagcctagta ggaaacgaag ggttgtccgt tcctttttcc aaatcaaagc
     4861 aaatacgatg acaaaaactc ccaaagctac gatattcatc ggcaaaccaa tgtaagtatt
     4921 cactccttgg ctgttaagaa gcaatttcaa tagtgagcga agcaagagca ctcctagagc
     4981 agcaggcaaa tccatgacca ccagacccac aaggactggc aagatactaa attcgatctt
     5041 gaggaaagat gccgctggta aaagcggaaa gtcaaagtac atcagcacaa atgagatggc
     5101 tgataaaatt gcaatggtcg aaagtcgacg tgtgtttgtc ataacaggtt cctccaattt
     5161 tctataaaat cagaagaagt tggaaaggat tcctctatct attctcactt tttatatccc
     5221 aaaagttccc tcttactcta ttaaagaaaa acaaagcaag tggttacaat ccggctataa
     5281 atctatcaaa acagacaaag ctattctttc gtcttctccc atccagacta tactgtcggt
     5341 tgtggaatct caccacatca gcttgcgctc gcggacttct ttaaagagaa ggaaatagag
     5401 atttttcttt tagactaggc gacaagctgt aggcataact tctggttagg caaagcttgt
     5461 caacaaagta taaaaggaaa agatcatttc ctagttaaag tcaccgccgg tcgggaatca
     5521 caccctgccc tgaagactct tttatcataa caaaaaacgc ttgcaagcgc aagcattttg
     5581 ttcattttca ttttttattt caatttatcc acttcatagg tatggacgag ctcaagacct
     5641 gcaaagttct gctggcgaag agcctcatag acaatcatgc agacggtatt agacacattg
     5701 agactgcgga catgttcatc attcatggga atacggagag ccttctcagg atgttctcgc
     5761 ataaaatctt caggtaagcc cttgtcttca cgtccaaaga gaaaataatg gtcctcgtca
     5821 gtcgataaat ccacctcaga atagactttt tccgcgaatt tcgaaatcag atagagtttt
     5881 cccttcatct gagatatgaa atcttccaaa ctctcgtaaa aataaatctc tagcttatcc
     5941 cagtaatcca atccagcccg cttcatcttg cggtcatcaa taggaaagcc cataggcttg
     6001 atgatgtgga ggggagaatt ggtcgcagcg caagtacgcg cgatattgcc cgtattttgt
     6061 ggaatttgag gttcaaataa tacaatgtga tttgtcatga cttgcttcct ttcaccattg
     6121 caaaaaaata gccacactgc ccggagtcaa gctcagcaaa cagcgtggtt aaggcatcgt
     6181 taacttacct cacaacaggt ttgaagtaaa tcagcgaaac tactttctta gtataacact
     6241 ttcagaatca ttgtcaatag aaatgacttg attttttcaa ttttttcaag ctatttccaa
     6301 gggttgtaaa atcgtccctg attctgcaag ataagtagta aactaactac taaaaacaag
     6361 gttgccaaga gcaaggtaat atagtctcct tttttcaagg cctgataact ataccatgtg
     6421 cgttttttct ctttcccaaa gcggcgaagc tccatggcag tcgcaatggt atcaatgcgt
     6481 tctagcgagc taaaaatcaa gggcgtaata atgagcagat tgcctttgat tcgttgcata
     6541 agagaagctt tcttggataa ttccatccca cgcgcctcct gagacatctt gatagtaaag
     6601 aattcttcct gcaaatctgg aatatagcgc aaggtcaggc tgacagaata agcaatctta
     6661 tagggcacac caatttgatt taaactggaa gcaaactgac taggatgggt tgtcatcaaa
     6721 aagataatag ccagaggaat ggtgcaaaga tacttaatgg ccaaatttag cagataaaag
     6781 agctcctggc tggttagagt gtagacaccg attccctgcc aaatcacact tctctctcca
     6841 taaagtccaa ccccatactc gggagaaaag agatagacca tcaaaacgtt taaaacggca
     6901 aataccgtcg caaaaacggc tacaaaggaa acatctttaa agcgaatttc tgataaatag
     6961 aggagaaaga ctgaaaagat ggcaatcagc aagagcattc tggtatcata gctaatcatg
     7021 gccgccaatg ataccagaat gaaaaagaga agtttcccag ctcctgacaa gcgatgaatc
     7081 acagtatctc tatgctggta accgattaat ttagcttgca tccctctctc ctttctttgt
     7141 aaaatgccgt taaatccagt ggatccacat ctagtttctt agccaagtta aagatggagg
     7201 tttcttttag attggctttt actaacagct caggatcgct caacagactg gctggaacag
     7261 tatcggcaat caattctcca tccaccatga caaggactcg atctgaataa tccagcatca
     7321 attgcatatc atgggtaatc atgacaatgg tatgcccttg ttgatgcagt tcttcgagaa
     7381 attccataat ctcagtatag ttcttctggt cttgacccgc agtcggttca tctaggagga
     7441 taatttcagc gcctaagacc aaaattgagg caatagtcac acgttttttc tgaccaaatg
     7501 acagggcaga aatgggccaa ttacggaatt catagagacc acagattttc aaggtttcat
     7561 agactctcgt ttcaatttcc tgctcgtcca cacctcgcaa acggagtccc agagccacct
     7621 catcaaaaat catattggtt gaaatcattt gattgggatt ttgcagcaca tagcctactc
     7681 gttccgcccg ctctgcaaca gaatctcctt ttatatcctg tccttcccaa agatagcggc
     7741 cttcagtctg gataaagcta ctcaaggcct tggctagagt tgacttccct gctccatttt
     7801 ttccgacaat agcaatcttt tcaccctttt taatatctaa atgtagggat tttaaaatcg
     7861 gtctatcatc ataagagaaa gacacgtcct ctaatttaaa gagtgactgc aattctggag
     7921 tttcttttgc cagttcattc tgcagctgaa cctgaccttt tgagatagac atgttatcca
     7981 gattcgctaa ctgttcttcc ttgactaagt ccacacctaa ttgacggaga gtcgttagat
     8041 aaaggggttc tcgaattcca ttttgagtca ataaatcagt cgcaagcaac tggtcagggc
     8101 tcccattaaa aaggatacga ccatcgttta tcaagacaat ccgatccaca gggcgatgca
     8161 gaacatcctc caaacggtgc tcgataatca gagtcgtcgt cccctcttcc ttatgaatct
     8221 ggtcaatcaa ttcgataata tcctgacctg atttgggatc tagattggcg agtggctcat
     8281 caaacaagag aatcggactt tcatcaatca agacaccagc cagactgact cgctgctttt
     8341 gtccacctga caaatcctga ggacgctgat ccagtaaagg aagaaggtcc agcttttcag
     8401 cccatttata aacacgacct ttcatctcat ctagggctgt cacatcattt tccagagcaa
     8461 acgccaaatc ttctgccaca gacaagccaa taaactgccc atctgtatcc tgcaaaactg
     8521 tgctaaccag atgagactta tcatagatgc tcatatcaaa ggctacttga ccctttatca
     8581 aaaattctcc atatgtctga cccttgtaaa tattgggaat aatcccattc aaacactgac
     8641 ccaaggtaga tttacctgac ccagatggtc caacaattaa gactttctct cccttgtaaa
     8701 tggtcaagtc tatcccttgc aaggtcggtt cttgttgtgt ttcataccgg aaagagaaat
     8761 ccttccactc aattatagct tctttcatct tactctcttc attcgcttct tagacttcta
     8821 ttttatcata aatcaagccc ttcttgcagt ctcttctctt aaaatcttag cgccaaaaag
     8881 attcctatcc tagcttactt gcctaactaa tctataaaca tcgaaaaaga ctagttgccc
     8941 agccttcccc atcattttat actcttcgaa aatctcttca aaccacgtca gcttcgcctt
     9001 gccgtaggta tggttactga cttcgtcagt ttcatctaca acctcaaaac catgttttga
     9061 gctgacttcg tcagtttcat ctacaacctc aaaaccatgt tttgagctga cttcgtcagt
     9121 tctatccaca atctcaaaac actgttttga gcaacctgcg gctaacttcc tagtttgctc
     9181 tttgattttc attgagtatt agtccttttt caaacttcct gcacgagttt gggttcctgc
     9241 ataggcaagt aagagaagag ttcctgcaat agctacagat acaccattgg caattcccgc
     9301 aacaatccct tgtgcaaata ctttttctgc cgcttcttga taaatcacaa catctccaag
     9361 tggtgccaag acaccccaaa caagggcatt tgcaagtagt tgaatgagat taaaaataag
     9421 aatatctttc cagtcaaaaa cactattgat cacgcgaacg tactttctaa aaagtcccac
     9481 aactaaacca aagagtccgc tagcgataat ccaagtccac catagaccat aaccaacaag
     9541 agagtccttg attgcatgac caatcaaccc gacaagcaaa ccgataatcg gtccaaaaat
     9601 aatagaaagt agcgcttgta ccgcatactg aagctggatg cttgtatttg gaacaggggt
     9661 tggaatgttg atcatcccga tgacgacaaa gagggcagcg ccaattccga cagcaacaac
     9721 ttgtttaatt gtaaatttga tttccatact attctcctat tttatccttc tattttcttt
     9781 atttcaatgg tccaagatga accgacacct acattatagg ccttggcaaa ggaaccttgg
     9841 ttgatagcca aacctaaacg atagagagag ttgatgtaaa ggatgggttg cccaattctc
     9901 acatctgcaa atgatttgcc atagacaacc tgattttgat agaccagcat atcagcatga
     9961 tagatggtca cttcaaaacg atcaccaaat tctggttcca gcttgtaaaa ttcttcccgt
    10021 gtgatagagg tccaaagcga accgaaacgc acatccagaa tatcaatggc tcccttcacc
    10081 agatgatctt ctatgatggt cgctacgact ggaagctcta caatctgttc cacactgagc
    10141 tctggcccta cttcctcaaa agtaatgtga ccactggcca gtttagcacc agtataggca
    10201 tagacatcac gaccgtggaa ggtataagaa tgctctgtgt tttgacgcct attggccacc
    10261 tcagaaatct cacgaatggc tacaatgcca acgtgtttct tgataaagga aagcgtccca
    10321 ttatctggcg tgacaatgta ttgatttttt gcagtcttgg caactacact cttacgtttc
    10381 gaaccgacac ctggatcgac aaccgataca aacgtcgttc cctcaggcca gtaatccacc
    10441 gtctgaaaga gacgatagct cccctcaaaa atattataag gcgtgatatc gtgcgtcaag
    10501 tgatggattt ttaaggttgg agactcttct aaagccactc caatcatagc cgataccgca
    10561 ccatcaacca gaccaaagtc tgattgtaat accagtaaat tattattcat tttatctcct
    10621 tgtatatcct ttatcatacc atatttcaga gaaagtcgct aatagctatt tcaattggtt
    10681 agggtatagt tttaacttat agcaaatttc ctactaaaag ctcttgttat tagctagtag
    10741 gtgcattttt tcttgaaaaa gggtatgata gttacatcat gaaaaagtag gttttattat
    10801 gaaaattatc cttgtcggag ggggaaaagt tggttttgcc ctctgtcgct ccttggttgc
    10861 agaaaagcat gatgttttgc tgattgagca agacgaagct gttctcaatc atattgtcag
    10921 tcgctttgat atcattggta tccttggtaa cggggccgat tttgccattc ttgagcaagc
    10981 cagcgtccaa gattgtgata tctttatcgc cctgactgag cacgatgaag tcaacatgat
    11041 tgcagcagtt ctagccaaga aaatgggagc taaagaaact atcgttcggg tgcggaaccc
    11101 tgaatattct aactcttatt tcaaggaaaa gaatattctc ggtttttctc ttatcgttaa
    11161 tcctgagctc ttggctgccc gcgctatcgc gaatatcatt gacttcccca acgccctgtc
    11221 tgtcgaacgc tttgctggtg gacgcgttag cctcatggaa tttgtcgtca agtccaccag
    11281 cggtctttgc caaatgccca tttctgattt tcgtaaaaaa tttggtaatg tcattgtctg
    11341 tgcgatagag agggatcatc aaattatcat tccaagcggt gacatgactg tacaggataa
    11401 agatagaatc tttgtcactg gtaaccgtgt cgatatgata ctcttccata attattttaa
    11461 atcacgcgcc gtgaagagcc ttctcatcgt tggggcaggt agaattgcct attatctact
    11521 tggtattctc aaagatagtc gtatcgatac aaaagtcatt gaaatcaatc ctgaaatcgc
    11581 cagcttcttt agcgagaaat tcccaaatct ctacatcgtt caaggagatg gaaccgcaaa
    11641 agatatcctg ctggaagaaa gtgctcaaca ctatgatgcc gttgcgactc taacaggagt
    11701 cgatgaggaa aatctgatta catctatgtt ccttgacagg gtaggtgtac agaaaaatat
    11761 tactaaggtc aatcgtacca gtctcctcga gattatcaat gcgcctgatt tttcaagtat
    11821 catcacacct aaaagcatcg ctgtagatac gattatgcac tttattcgtg gtcgagttaa
    11881 tgcccagtat tcagaccttc aagccatgca ccatctagcc aatggccaaa tcgaaaccct
    11941 gcaattccat atcaaggaag ccaataaaat gactgccaaa cctctttctc aactgaaatt
    12001 gaaaaaagag gttcttattg cagccattat tcgaaagggc aagactattt tcccaactgg
    12061 ggaggatatg ttggaagttg gagacaagct cctagtaaca accttgttgc caaacatcac
    12121 caagatttat gacttgattg cgaggtaaga aatgaataaa agtatgattc gttacctcct
    12181 ttcaaagtta cttttgattg aagctgttct cctcttggtt cctgtggcta tcgctgtcta
    12241 ttaccgtgaa tcgagccaag tctttacagc cctcttttcg accataggga ttctcgtatt
    12301 gttaggcggt tcagggagtt tacagaagcc aaaaaatcaa cggatttatg ccaaggaggg
    12361 agtcttgatc gttgccctct gttggatcct ttggtctttc tttggtggtc tcccctttgt
    12421 cttttctggg caaatcccca gccttattga tgcctttttt gaaattagtt ctgggtttac
    12481 aactactgga gcaagtattt tgaacgacgt ttcggttctc agccgttccc tcctcttctg
    12541 gcgaagtttt acccacttga ttggagggat gggagtgctt gtttttgcac ttgctattat
    12601 ggacaatgcc aaaaatagcc acctagaggt gatgaaggct gaggttccag gtcctgtttt
    12661 tggcaaggtt gtatccaaac taaaaaacac tgcccagatt ctctatctcc tttatctagc
    12721 tctcttctcc ctctttgtca tcatctatta tctagctggt atgcctctct acgatagttt
    12781 tgtcattgct atggggacag cgggaactgg aggctttacc gtctataacg acggaattgc
    12841 ccactatggc agctcactga ttacctatct ggtcagtatc ggagttctgg tttttggggt
    12901 aaatttcaac ctctactact acctcatgct ccgtcgcatc aaggccttct ttggtgacga
    12961 agaacttcgg gcttacttgg tcattgtact ggtttctaca ggcttgatta gcctcaacac
    13021 cctctacctc tacccagggt tttcaaagag ctttgaaatg accttcttcc aggtttccaa
    13081 catcattaca acaactggtt ttggatatgg agatattacc aactggcccc tcttctccca
    13141 gtttatcctc cttttcctca tggcaatcgg tggctctgct ggatcaactg caggtggact
    13201 caagattatt cgaggcctca tcctttcaaa aattgccaaa aaccaaattt tgtcaatcct
    13261 atcgccccac cgtgttttga ccctccatgt gaatcaaacg gtgattgata aagataccca
    13321 gcataagatt ctcaagtact ttgtcatcta tgctatgatt ttgctagcgc ttatctttat
    13381 tgtcagccta gatagcaatg attttctggt cgtgaccagc gctgtcttta gctgtttcaa
    13441 taatatcggg cctattctag gaaccacttc tagtttctca atctttagtc ccatctcaaa
    13501 aattctccta tcctttgcaa tgattgcagg gcgcttggag atttacccaa tcctccttct
    13561 ctttatgaag agaacttggt ctaagagata aaatacaaaa tccctctttt tacaattgtg
    13621 aaagagggat tcttatatta aaaaaggggg aacgttttta aatccaagcc tatctgtaag
    13681 caaaatcctt actcaaataa aagatggaaa aacttactac acagcttggt aatgctccaa
    13741 tacaaattgt aaggatttac ttggactctt tgttaaatga atatattcca ttcctctggt
    13801 agcaactatc tgaataccta atctttctgc atccaccttc atctctctat aataactccg
    13861 aacttgtgga gccagaataa ttaaatcata aacacccata atatcataat gagctccgta
    13921 cgctcctgaa ttcgcaatca ctctaacttc tgctaattga gcgccctcgt taattgcatt
    13981 ggctaattgc gcacttgttc cagaccctgc acaaagaacc agtactttca actccttact
    14041 ttttatttca tctaactcac caggcattat ttcacttgtc tcctcctcta aaataatatc
    14101 atttgagctt gcaacatctt ctttcatcag taactgtcta tcatacgctc tacagaatgg
    14161 caaataaatc aatatgtcga caactaaaat caaagataaa aatacaaagg agatagattg
    14221 aaaattcgtt ccaattaaca atcccaaggg accaggaaag gcccaaggta actggatata
    14281 aaatccattc attccaaaga aatcaataaa gacctttcct agaaatacat tcactggtgg
    14341 agtcatcaaa aaaggtacaa aaagataggg attcaaaata actggcatac caaatagaag
    14401 aggttcattc accgcaaata aaacaggagt aattgtagct ttacctaccg attttaattg
    14461 tttagaccgc ataaagaaaa tcaaaataaa tggtacaaca aaggtagccc ccgttcctcc
    14521 gatagcagcg atataatttc cgaaattagg cgttaaagaa tgataaggaa actgcccatt
    14581 tgcaagaagt tgagcattct cttccatatt gctcagttgt aaagctgtaa cagcaggtaa
    14641 gacaatagat ggtccatgaa ttccaacaaa ccaaagcaaa gcgcacataa accaaatcaa
    14701 catcatagca ggatatgatt ctgccccctt aaaaatagga gtcaatagtt gttgaaatac
    14761 ttgggcaaaa ggaacatcta aactaaaccg agatacaata tctaacaaac cactaataag
    14821 taaaacaaaa gaaaaaggaa aaatatctct aaaagcttgt gatatagccc caggaacttc
    14881 cttaggtaaa tgaatagtaa tgtctcgctt aatacagaat cggtaaacat ttacagtaat
    14941 aaaggcactg acaaacgaag ttatcaatcc ttgagatcct aaatagtttg tcgacaaact
    15001 tgtagatccc gttttctcat caactacaag cgttacagtt aatacaagat agccacatat
    15061 ggccgccaac attgcagaag tatcatttat tacctttcca ggaggcattt ttctattaac
    15121 atttccagcc aatgactttg caactgtccc tgaaacaata acacccaaaa ctcccatggt
    15181 tagcatatac actttcctca tccaggcaat agctggactc ggtaactcta ctccgaaatt
    15241 tttaggaatc ataataataa tcatcaaaaa gcttgaaaac ataattaaag gcatagtagc
    15301 aataaatcca tctttaatag ccatcatata attattagta gaaatttttt caaatttccc
    15361 ttgttgcttt tcaatggcag cgactaactt atccataaaa actcctcctg taaaaaattt
    15421 aagctcatag ttaaaatata ttaaacatca gtcaaatcgc taaccttaat tccgttttaa
    15481 tccttttacc caaagagcac ttttcttaat atatctcttc tgtgtttcat aatcaacaaa
    15541 gaaaagacca tatcgcttat tgtagccatt cgcccaagaa aattgatctt gcaaagacca
    15601 tataaaatag ccttgaatat tgactcccct atctcgagcc tctaaaactt tgtgtaaatg
    15661 ttgctcaata taacggattc ttttactgtc atcaataata tcattctcgc cctctggctt
    15721 aacctcttta agggctgtac cattttcagt taaataaatg accggatgtt gaggatattc
    15781 ttctttgata cgaagcaaca tatcaaataa cccttgagga taaatattcc aatcccaatc
    15841 tgttgtcgga ataccaggct tttttacaaa ttcacctaga gcatttaatt taaaagaaga
    15901 ctgtcctttt attcctgttg aattaaattc ttgtctattt tcacctttgt attcacgaat
    15961 aaattctgaa cgataataat tcatcccaaa catcgtatta agaggtgcag ctcttttcat
    16021 aatttctaaa tcaccatctt caataataaa gctagaatta ttagcttcca atatttgatt
    16081 caagtgaaaa agcgtgtcat cactgtagta gcccaaaaaa gttccatcta atagaaattt
    16141 attattataa acatcatacc gtttagctgc taaaatattt tctttttgcc catcaatagg
    16201 atagcctggc tttaaagcat gaatacaacc tatctctccc tcaattccta attgatgaaa
    16261 ttcgaggact gcaagagcat gcgccaacaa catattatga ttcgcttgaa ttgcttcaga
    16321 taattgaaaa tgatgatttg gaggaaactg acctcctata tattgacctg cagcaagaga
    16381 catcagttca ttgattgtaa accaatgctt gacttctgta aattcttgga aacaaaagcg
    16441 agcatatcgt atgaaacgat caatattctc tctattcaac caatcccctg tttctaacat
    16501 tttctgaggc gaatcaaaat gatgtaaaga aacaaacgga atcacattat gttttaagca
    16561 agactgaaag actctatggt aataacgaac agctaatata ttcggctccc catctatatc
    16621 aggaaatata cgaacccaag aaatagataa acgcaaagcc tgcaaaccat gttctgccgc
    16681 caaagctata tcctcttcgt aacgataata aaaatcacta gctggatctg gtaagaacgg
    16741 actattttct tgcaaataaa catcccacat atttattcct ttgccatcta ccctagttgc
    16801 accctctact tgataagcag cggtagcagc tcctaataaa aactccttcg gtaaggcttt
    16861 aaactgtaaa ttttccatga ctaatcctca ttgcaaacca atatgttctt caatctttcg
    16921 aattcgttca tattcatcaa taaaaaactt tacctgatca tacaatagca tcgttgtcat
    16981 caaagtatct tgaccatgaa tcataataaa gctcacttca aaattatctc catatgcctc
    17041 ctccgctaat aaattagtct gttctcgatg ggcagacact attgagtcgt ttgcagactc
    17101 aaccaattct cttgcctgtt caaaatatcc atctctcgca aacgccaaag catccatcaa
    17161 atctgacctt gcatctcctg cgtaagcgac aattgtaaaa ccaagcatat ttatttcttc
    17221 ttttgatttc atctttcttc ctcctcaatc ttgatccatc ttttacacat cattattaaa
    17281 atgacttcgc tacgatataa atagaaagtc gaccctaaat atcttaaaaa tccttaaatt
    17341 tcataatatt taggatcaat cttctctgaa taccttggtt cattttctat acttatgatt
    17401 tataagtgga aaccagcgta attttttgct acttcaatta cacgataaac atccaaatta
    17461 gattggaata gcagttcgtg cccacggata taattcaaca catttctcca ttcatcttga
    17521 gcttgccttg tttttccggt tgcttgaaga tataaagcct tcgccatctt aacaacatat
    17581 tcacgatgat aactgagctg tttccattca tccttttgac tatttaataa cttagaaata
    17641 ttttcctcaa taattggcaa aaaattatca gctagattgt aagctatata ataatgattc
    17701 gctaaaacat cattttgacg actgccaatt gcattaaaat aatcacatga ggaataactg
    17761 gataattttt ctaaatattc aacaacagac tgccaatttg acccatacaa agcagaaaag
    17821 tattcttcaa tcaattcttc ataacttctt gtcttcttcc agagcatttc ccccataaca
    17881 taattaggaa aattatgagg gaatccggca cgtaattctt gacacgaaat gtaaccgttc
    17941 aaatgtaggt tagaaagata agatacatct ctgtaaatgg tttgactaat tttcatatag
    18001 cctaaatcgc cataatgagc acgccctaaa ggatagtcat atacgaaact atctccttta
    18061 aatgtttttt gccactcaaa aagataagat aaattttcct caagagaatt cggaagtata
    18121 attttattac gcagataagg tttaggcgta ggtatggaat tgtcaaaatc tacatctgca
    18181 taactcattt caaatgttct tgtaatcggt gcaaacatca tggtaaagcg ttcaggatta
    18241 tctaattttt ctttctgagg cgcccatagc aactcatggt aaagcagaaa acaaatcttt
    18301 gtatctaatc cctcactcgt taaagcccta tccaattgat tgagaatacg aatatactga
    18361 tccgaaacca attcttgtct acagttttcg cattcacaaa tattattacg agcatccgac
    18421 aaccatacat gtaagtagtt aacatcaggt cttttcttgg cataatcctt gataatttct
    18481 accatcttat ccgccacatc tggatttgaa aaatccagac tggttaaaat cggagccgta
    18541 ttaaataatt ctcgtttccc gtttatttca gcgacatacg gtttcttctc ctctgaaata
    18601 ctaagacctg attcccagcc aaattttgaa gagtaaccta aaacctcacc tgtccatcca
    18661 tgaccaacac gatgatgaat aagacctctt ttttgcaatt ctttatccaa cctatcactc
    18721 aattcttgta ctaattcatt tgagaatttt tctttattta ggtatggatt aaactcatgt
    18781 tcataccaac gtttcaaaaa agagtaggga ttttcaaact ggatgaaaaa actgttcatc
    18841 ccaatcttag gtagccaatc aatgaaatct agtatatttt caaatgaatc cgctccctct
    18901 atacatactc ccctatgata gtaactggct gtttcatcta tagatagctg tttatctaaa
    18961 aaatcttcaa atcgtaactc tggaacaaag tcatgtctgt gccctggtct agtatacaca
    19021 accccaaatt catgaaacat tcggtaaatt ccaataagta aacctacaat tgtattagac
    19081 tcaattctcc ccttaccctt gtctaatgag ataagaacat ggtctcttct atcctcttta
    19141 ttgactaatc ctacaaaaat atccgcttcc ttctcctcga caagttctat gtcagtctta
    19201 aagacccgat ttatatagta acttaattcc tctaaggcaa agctagaata agtatttttc
    19261 tgcttatcaa atactctgat aaccatctta tttccctcca acagtagctt tttctttttc
    19321 aagattgcgt ttatctgcaa ttttgaagaa tggataataa attgctacag aaaccaaaat
    19381 caaaacaact tgtaatagag ctcctcgcca actagctcct gtcgcaagga agcctcctat
    19441 gatcggtggc attgtccacg gaaggattac acctgttgta tagggtacta atcctacagc
    19501 cattgataca taggtaatta aggcattgat tgtaggagta gcaataaacg gaatcagcat
    19561 aatcggattt aaaactgttg gaaacgtaaa tagaatagct gtattgatat taaaaataga
    19621 cggtataata gctagcttac ctaatgtttt attcgcacga ctcttactaa ataggaagag
    19681 acaaatcgca agaccaatag tcgctccacc gccaccaata aatacaaata aatctttaaa
    19741 cggtaatgta ataatgtgtt ggagtgtttg tcctgcagcc acagcttctt ggttttctgt
    19801 agtaaattgt aaccaaactg gatctacaaa agcatttaaa acttgtcccc cattaactcc
    19861 acagaaccaa aagaatgagt ttacaataac acatagaatc atacctggaa gcgttcctgc
    19921 aattaactta agcggtgttc caacaattgc acctaggagt ccgttgagac ctcctgcaac
    19981 tcctgccgct tcaagacctt ttaagaccag agcccacaaa acaaaagtag taaagccagg
    20041 taaaagagct gaaaatgatt tacttaccac atctgggaca ccacttggca tttttatcgt
    20101 aattccgcgc tggataaaca tacgataaat ctctgctgta accaatccaa tagtaatcgc
    20161 cataaacaaa gaagatgcat tcaggctaga aaatggtatt gcgccgccaa ataactgctt
    20221 gacctgctcc ccatttttat cataaaccat actcgaaaaa cgaggtgcca tcaatacaaa
    20281 actggataag gctatgatcc ctgccgacgg accatctgta ccatatcctt ccgacaacct
    20341 gtaggcaata ccgaaacaag cgaccaagga gataatcgct actgttgact gattcatagt
    20401 tgtcaagata cttagcaatc caacactatt cagccaattt gtaaaatcct cttgaggcca
    20461 actgattaga ataagaaata aagagccgac taaaatcaaa ggcattgcca tcataaatcc
    20521 ttcacgaata gctttcaaat gccgttggtt gccaactttt tcaccaaacg gagcgacttt
    20581 tgtttctaaa aacgttaaaa tattgttcat caccggaact ccttttttta ttttttataa
    20641 attaaatata
//
LOCUS       DAVHSO010000039        20127 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.039, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000039 DAVHSO010000000
VERSION     DAVHSO010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20127)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20127)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20127
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.039"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            389..616
                     /locus_tag="VVR18_001418"
     CDS             389..616
                     /locus_tag="VVR18_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032923.1"
                     /translation="MIFKAFKTKKQRKRQVELLLTVFFDSFLIDLFLHLFGIVPFKLD
                     KILIVSLIIFPIISTSIYAYEKLFEKVFDKD"
     gene            904..3801
                     /gene="nanA"
                     /locus_tag="VVR18_001419"
     CDS             904..3801
                     /gene="nanA"
                     /locus_tag="VVR18_001419"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored neuraminidase NanA"
                     /protein_id="HEU6032924.1"
                     /translation="MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASE
                     QPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLEN
                     VETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSS
                     ATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAE
                     LPNGRVRLYVNGVLSRTSLKSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTV
                     YNRALTPEEVQKRSQLFKRSDLEKKLPEGAVLTEKTDIFESGRNGKPNKDGIKSYRIP
                     ALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASD
                     PSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILY
                     REGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGDQLLGNIYFTTN
                     KTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPH
                     KGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMN
                     NERAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQ
                     MSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSL
                     QELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSKDLISPTEAKVKRTREMGKGEMG
                     KGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKG
                     SIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLV
                     TLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ"
     gene            4817..5269
                     /locus_tag="VVR18_001420"
     CDS             4817..5269
                     /locus_tag="VVR18_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEU6032925.1"
                     /translation="MIITKISRLGTYVGVNPHFATLIDFLEKTGLENLTEGSIAIDGN
                     RLFGNCFIYLADGQAGAFFETHQKYLDIHLVLENEEAMAVTSPENVSVTQEYDEEKDI
                     ELYTGKVEQLVHLRAGECLITFPEDLHQPKVRINDEPVKKVVFKVAIS"
     gene            5288..6625
                     /locus_tag="VVR18_001421"
     CDS             5288..6625
                     /locus_tag="VVR18_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HEU6032926.1"
                     /translation="MKKMRKFLCLAGIALAAVALVACSGKKEATTSTEPPTELSGEIT
                     MWHSFTQGPRLESIQKSADAFMQKHPKTKIKIETFSWNDFYTKWTTGLANGNVPDIST
                     ALPNQVMEMVNSDALVPLNDSIKRIGQDKFNETALNEAKIGDDYYSVPLYSHAQVMWV
                     RTDLLKEHNIEVPKTWDQLYEASKKLKEAGVYGLSVPFGTNDLMATRFLNFYVRSGGG
                     SLLTKDLKADLTSQLAQDGIKYWVKLYKEISPQDSLNFNVLQQATLFYQGKTAFDFNS
                     GFHIGGINANSPQLIDSIDAYPIPKIKESDKDQGIETSNIPMVVWKNSKHPEVAKAFL
                     EALYNEEDYVKFLDSTPVGMLPTIKGISDSAAYKENETRKKFKHAEEVITEAVKKGTA
                     IGYENGPSVQAGMLTNQHIIEQMFQDIITNGTDPMKAAKEAEKQLNDLFEAVQ"
     gene            6704..7588
                     /locus_tag="VVR18_001422"
     CDS             6704..7588
                     /locus_tag="VVR18_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6032927.1"
                     /translation="MVKERNLTRWIFVLPAMIIVGLLFVYPFFSSIFYSFTNKHLIMP
                     NYKFVGLANYKAVLSDPNFFNAFFNSIKWTVFSLVGQVLVGFVLALALHRVRHFKKLY
                     RTLLIVPWAFPTIVIAFSWQWILNGVYGYLPNLIVKLGLMEHTPAFLTDSTWAFLCLV
                     FINIWFGAPMIMVNVLSALQTVPEEQFEAAKIDGASSWQVFKFIVFPHIKVVVGLLVV
                     LRTVWIFNNFDIIYLITGGGPANATTTLPIFAYNLGWGTKLLGRASAVTVLLFIFLVA
                     ICFIYFAIISKWEKEGRK"
     gene            7588..8421
                     /locus_tag="VVR18_001423"
     CDS             7588..8421
                     /locus_tag="VVR18_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU6032928.1"
                     /translation="MKKKSGIYLDILSHVLLVGATIVAVFPLVWIIISSVKGKGELTQ
                     YPTRFWPEQFTLDYFTHVINDLHFIDNIRNSLIIALATTLIAIIISAMAAYGIVRFFP
                     KLGAIMSRLLVITYIFPPILLAIPYSIAIAKVGLTNSLFGLMMVYLSFSVPYAVWLLV
                     GFFQTVPIGIEEAARIDGANKFVTFYKVVLPIVAPGIVATAIYTFINAWNEFLYALIL
                     INNTGKMTVAVALRSLNGSEILDWGDMMAASVIVVLPSIIFFSIIQNKIASGLSEGSV
                     K"
     gene            8440..10533
                     /gene="nanB"
                     /locus_tag="VVR18_001424"
     CDS             8440..10533
                     /gene="nanB"
                     /locus_tag="VVR18_001424"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="neuraminidase NanB"
                     /protein_id="HEU6032929.1"
                     /translation="MNKRGLYSKLGISVVGISLLMGVPTLIHANELNYGQLSISPIFQ
                     GGSYQLNNKSIDISSLLLDKLSGESQTVVMKFKADEPNSLQALFGLSNSKAGFKNNYF
                     SIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGKHKGQAVENTLVFVSDSKDKTYTMY
                     VNGIEVFSETVDTFLPISNINGIDKATLGAVNREGKEHYLAKGSIDEISLFNKAISDQ
                     EVSNIPLSNPFQLIFQSGDSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKIN
                     IATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDK
                     KSGKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVRENGVVY
                     DETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLREKHNGKQVPMNVFYKDSL
                     FKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHNGTYLCPGQGLALKSSNRLIFAT
                     YTSGELTYLISDDSGQTWKKSSASIPFKNATAEAQMVELRDGVIRTFFRTTTGKIAYM
                     TSRDSGETWSEVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQL
                     VVGLVNKEDDSIDWKYHYDIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLS
                     NVVQYIDLEINDLTK"
     gene            10545..11648
                     /locus_tag="VVR18_001425"
     CDS             10545..11648
                     /locus_tag="VVR18_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEU6032930.1"
                     /translation="MVKYGVVGAGYFGAELARYMQKNDGAEITLLYDPDNAEAIAEEL
                     GAKVASSLDELVSSDEVDCVIVATPNNLHKEPVIKAAQHGKNVFCEKPIALSYQDCRE
                     MVDVCKENNVTFMAGHIMNFFNGVHHAKELINQGVIGDVLYCHTARNGWEEQQPSVSW
                     KKIREKSGGHLYHHIHELDCVQFLMGGMPETVTMTGGNVAHEGEHFGDEDDMIFVNME
                     FSNKRFALLEWGSAYRWGEHYVLIQGSKGAIRLDLFNCKGTLKLDGQESYFLIHESQE
                     EDDDRTRIYHSTEMDGAIAYGKPGKRTPLWLSSVIDKEMRYLHEIMEGAPVSEEFAKL
                     LTGEAALEAIATADACTQSMFEDRKVRLSEIVK"
     gene            11822..12520
                     /locus_tag="VVR18_001426"
     CDS             11822..12520
                     /locus_tag="VVR18_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HEU6032931.1"
                     /translation="MPQISKEALIEQIKDGIIVSCQALPHEPLYTEVGGVIPLLVKAA
                     EQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIE
                     VIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTL
                     SGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAIT
                     RPKEITERFVASLK"
     gene            12539..14056
                     /locus_tag="VVR18_001427"
     CDS             12539..14056
                     /locus_tag="VVR18_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEU6032932.1"
                     /translation="MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPIL
                     DNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKRDKGTAALAGVTGYLVMTATI
                     KALVKLFMAEGSAIDTGVIGALVVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTS
                     FSSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPM
                     FWYTELGGVETVAGQTVVGAQKIFFAQLADLAHSGLFTEGTRFFAGRFSTMMFGLPAA
                     CLAMYHSVPKNRRKKYAGLFLGVALTSFITGITEPIEFMFLFVSPVLYVVHAFLDGVS
                     FFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPFGLIWSVLYYIIFRWFI
                     TQFNVLTPGRGEEVDSKEISESADSTSNTADYLKQDSLQIIRSLGGSNNIEDVDACVT
                     RLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQAIYGAKAILYKNSINEILGVDD"
     gene            14181..15509
                     /locus_tag="VVR18_001428"
     CDS             14181..15509
                     /locus_tag="VVR18_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6032933.1"
                     /translation="MKFRKLACTVLAGAAVLGLAACGNSGGSKDAAKSGGDGAKTEIT
                     WWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDIKVKLETIDFKSGPEKITTAIEAGT
                     APDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPISS
                     APFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGT
                     RAFISNLYSGSVTDEKVSKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNF
                     ANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSDEGKPALEYLVNGFAVFNNKD
                     DKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP
                     YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQ"
     gene            15761..16627
                     /locus_tag="VVR18_001429"
     CDS             15761..16627
                     /locus_tag="VVR18_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6032934.1"
                     /translation="MRETVISYAFLAPVLFFFVIFVLAPMVMGFITSFFNYSMTKFEF
                     VGLDNYIRMFKDPVFTKSLINTVILVIGSVPVVVLFSLFVASQTYHQNVIARSFYRFV
                     FFLPVVTGSVAVTVVWKWIYDPLSGILNFVLKSSHIISQNISWLGDKNWALMAIMIIL
                     LTTSVGQPIILYIAAMGNIDNSLVEAARVDGATEFQVFWKIKWPSLLPTTLYIAIITT
                     INSFQCFALIQLLTSGGPNYSTSTLMYYLYEKAFQLTEYGYANTIGVFLAVMIAIVSF
                     VQFKVLGNDVEY"
     gene            16643..17482
                     /locus_tag="VVR18_001430"
     CDS             16643..17482
                     /locus_tag="VVR18_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU6032935.1"
                     /translation="MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPD
                     TIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAK
                     KRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM
                     KQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLV
                     MLTSRNNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGA
                     VKG"
     gene            17755..18207
                     /locus_tag="VVR18_001431"
     CDS             17755..18207
                     /locus_tag="VVR18_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEU6032936.1"
                     /translation="MIFDDLKNITFYKGIHPNLDKAIDYLYQHRKDSFELGKYEIDGD
                     KVFLVVQENVLNQVENNQFEHHKNYADLHLLIEGHEYSSYGSRIKDEAVAFDEASDIG
                     FVHCHEHYPLLLGYHNFAIFFPGEPHQPNGYAGMEEKVRKYLFKILID"
     gene            18304..18648
                     /locus_tag="VVR18_001432"
     CDS             18304..18648
                     /locus_tag="VVR18_001432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032937.1"
                     /translation="MVSSKYAARASFLDGQGITVDEMSWIIRGIVNGLIGRYIKLGTY
                     AAKYGISMARSILSRAAATAAARVRLLTKIFGWILRIAVLAADVYGNFANNIAAAWDA
                     HDKIPNNGRINF"
     gene            18935..19579
                     /locus_tag="VVR18_001433"
     CDS             18935..19579
                     /locus_tag="VVR18_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000057467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEU6032938.1"
                     /translation="MAQKGVSLIKAAFDTDNFLMRFSEKVLDIVTANLLFVVSCLPIV
                     TIGVAKISLYETMFEVKKSRRVPVFKIYLRSFKQNLKLGLQLGLLELGIVSLSLLDLY
                     LFWGQTALPFQLLKAICLGILIFLTIVMLASYPIAARYDLTWKEILQKGLMLASFNFP
                     WFFLMLAILVLIVMVLYLSAFSLLLGGSVFLLFGFGLLVFIQTGLMEKIFAKYQ"
     gene            19748..>20127
                     /locus_tag="VVR18_001434"
     CDS             19748..>20127
                     /locus_tag="VVR18_001434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HEU6032939.1"
                     /translation="MSDLKKYEGVIPAFYACYDEQGEVSPERTRALVQYFIDKGVQGL
                     YVNGSSGECIYQSVEDRKLILEEVMAVAKGKLTIIAHVACNNTKDSMELARHAESLGV
                     DAIATIPPIYFRLPEYSVAKYWND"
BASE COUNT         6526 a         3320 c         4182 g         6099 t
ORIGIN      
        1 gtgttttgag ctgacttcgt cagtcttatc taccacctca aaacagtgtt ttgagcatca
       61 tgcggctagc ttcttagttt gctctttgat tttcattgag tataaaaaca gatgagtttc
      121 tgttttcttt ttatggacta taaatgttca gctgaaacta ctttcaagga cattattata
      181 taaaagaatt ttttgaaact aaaatctact atattacact atattgaaag cgttttaaaa
      241 atgaggtata ataaatttac taacacttat aaaaagtgat agaatctatc tttatgtata
      301 tttaaagata gattgctgta aaaatagtag tagctatgcg aaataacaga tagagagaag
      361 ggattgaagc ttagaaaagg ggaataatat gatatttaag gcattcaaga caaaaaagca
      421 gagaaaaaga caagttgaac tacttttgac agtttttttc gacagttttc tgattgattt
      481 atttcttcac ttatttggga ttgttccctt taagctggat aagattctga ttgtgagctt
      541 gattatattt cccattattt ctacaagtat ttatgcttat gaaaagctat ttgaaaaagt
      601 gttcgataag gattgagcag gaagtatggt gtaaatagca taggctgatg tccatcattt
      661 gcttataaag agatatttta gtttaattgc agcggtgtcc tggtagataa actagattgg
      721 caggagtctg attggagaaa ggagagggga aatttggcac caatttgaga tagtttgttt
      781 agttcatttt tgtcatttaa atgaactgta gtaaaagaaa gttaataaaa gacaaactaa
      841 gtgcattttc tggagtaaat gtcttatttc agaaatcggg atatagatat agagaggatc
      901 agtatgaatc ggagtgttca agaacgtaag tgtcgttata gcattaggaa actatcggta
      961 ggagcggttt ctatgattgt aggagcagtg gtatttggaa cgtctcctgt tttagctcaa
     1021 gaaggggcaa gtgagcaacc tctggcaaat gaaactcaac tttcggggga gagctcaacc
     1081 ctaactgata cagaaaagag ccagccttct tcagagactg aactttctgg caataagcaa
     1141 gaacaagaaa ggaaagataa gcaagaagaa aaaattccaa gagattacta tgcacgagat
     1201 ttggaaaatg tcgaaacagt gatagaaaaa gaagatgttg aaaccaatgc ttcaaatggt
     1261 cagagagttg atttatcaag tgaactagat aaactaaaga aacttgaaaa cgcaacagtt
     1321 cacatggagt ttaagccaga tgccaaggct ccagcattct ataatctctt ttctgtgtca
     1381 agtgctacta aaaaagatga gtacttcact atggcagttt acaataatac tgctactcta
     1441 gaggggcgtg gttcggatgg gaaacagttt tacaataatt acaacgatgc acccttaaaa
     1501 gttaaaccag gtcagtggaa ttctgtgact ttcacagttg aaaaaccgac agcagaattg
     1561 ccaaatggtc gagttcgcct ctacgtaaac ggggtattat ctcgaacaag tctgaaatct
     1621 ggcaatttca ttaaagatat gccagatgta acgcatgtgc aaatcggagc aaccaagcgt
     1681 gccaacaata cggtttgggg gtcaaatcta cagattcgga atctcactgt gtataatcgt
     1741 gctttaacac cagaagaggt acaaaaacgt agtcaacttt ttaaacgctc agatttagaa
     1801 aaaaaactac ctgaaggagc ggttttaaca gagaaaacgg acatattcga aagcgggcgt
     1861 aacggtaaac caaataaaga tggaatcaag agttatcgta ttccagcact tctcaagaca
     1921 gataaaggaa ctttgatcgc aggtgcagat gaacgccgtc tccattcgag tgactggggt
     1981 gatatcggta tggtcatcag acgtagtgaa gataatggta aaacttgggg tgaccgagta
     2041 accattacca acttacgtga caatccaaaa gcttctgacc catcgatcgg ttcaccagtg
     2101 aatatcgata tggtgttggt tcaagatcct gaaaccaaac gaatcttttc tatctatgac
     2161 atgttcccag aagggaaggg aatctttgga atgtcttcac aaaaagaaga agcctacaaa
     2221 aaaatcgatg gaaaaaccta tcaaatcctc tatcgtgaag gagaaaaggg agcttatacc
     2281 attcgagaaa atggtactgt ctatacacca gatggtaagg cgacagacta tcgcgttgtt
     2341 gtagatcctg ttaaaccagc ctatagcgac aagggtgatc tatacaaggg tgaccaatta
     2401 ctaggaaata tctacttcac aacaaacaaa acttctccat ttagaattgc caaggatagc
     2461 tatctatgga tgtcctacag tgatgacgac gggaagacat ggtcagcgcc tcaagatatt
     2521 actccgatgg tcaaagccga ttggatgaaa ttcttgggtg taggtcctgg aacaggaatt
     2581 gtacttcgga atgggcctca caagggacgg attttgatac cggtttatac gactaataat
     2641 gtatctcact taaatggctc gcaatcttct cgtgtcatct attcagatga tcatggaaaa
     2701 acttggcatg ctggagaagc ggtcaacgat aaccgtcagg tagacggtca aaagatccac
     2761 tcttctacga tgaacaatga acgtgcgcaa aatacagaat caacggtggt acaactaaac
     2821 aatggagatg ttaaactctt tatgcgtggt ttgactggag atcttcaggt tgctacaagt
     2881 aaagacggag gagtgacttg ggagaaggat atcaaacgtt atccacaggt taaagatgtc
     2941 tatgttcaaa tgtctgctat ccatacgatg cacgaaggaa aagaatacat catcctcagt
     3001 aatgcaggtg gaccgaaacg tgaaaatggg atggtccact tggcacgtgt cgaagaaaat
     3061 ggtgagttga cttggctcaa acacaatcca attcaaaaag gagagtttgc ctataattcg
     3121 ctccaagaat taggaaatgg ggagtatggc atcttgtatg aacatactga aaaaggacaa
     3181 aatgcctata ccctatcatt tagaaaattt aattgggaat ttttgagcaa agatctgatt
     3241 tctcctaccg aagcgaaagt gaagcgaact agagagatgg gcaaaggaga gatgggcaaa
     3301 ggagttattg gcttggagtt cgactcagaa gtattggtca acaaggctcc aacccttcaa
     3361 ttggcaaatg gtaaaacagc gactttccta acccagtatg atagcaagac cttgttgttt
     3421 gcagtagata aggaagatat cggacaggaa attattggta tagctaaagg aagcatcgaa
     3481 agtatgcata atcttcctgt aaatctagca ggtgccagag ttcctggcgg agtaaatggt
     3541 agcaaagcag cggtgcatga agttccagaa tttacagggg gagttaatgg tacagagcca
     3601 gctgttcatg aaatcgcaga gtataaggga tctgattcgc ttgtaactct tactacaaaa
     3661 gaagattata cttacaaagc tcctcttgct cagcaggcac ttcctgaaac aggaaacaag
     3721 gagagtgacc tcctagcttc actaggacta acagctttct tccttggtct gtttacgcta
     3781 gggaaaaaga gagaacaata agagaagaat tctaaacatt tgattttgta aaaatagaag
     3841 gagatagcag gttttcaagc ctgctatctt tttttgatga cattcaagct gatacgaaat
     3901 cataagaggt ctgaaactac tttcagagta gtctgttcta taaaatatag tagattgaaa
     3961 taagatgtga acaactctat caggaaagtc aaattaattt atagaaaaat tttagcagtc
     4021 aaggtgtact gttatagatt caatatatta tgcgactatt aaccttgtct tctcctaaaa
     4081 ttgactttct tgttttctta tcttgtccac tcgaaacaag tattgtaaga atttgattat
     4141 ttttgaaagt acttttaata tacttgatat agttaaaaaa gatttgaaac taaattccaa
     4201 attagaaaaa gacttgaaat actaaaaaaa aaaaagtata ctctaattga aaacggtaac
     4261 aaaactaatt tagagaatga aatatagagt atttctctct taaaagtttt tggtgaaacg
     4321 agatgtagaa aggagattta gccaaagagt ctattagtgc tagaataata gattagaatt
     4381 attttagaaa aacgaagtga gcagcttata aattcaagtc cccaaataga ttcatactag
     4441 tatcttttgc aaaaaataaa gggcgacttc cttcatgaat atcaatttca tctataagga
     4501 aggtagctaa ttgaactaac ttatttattc tgtttgtcgc tagaaaaatc agacctcctt
     4561 gtgaagattg aggagatact gaatgaaaat caaagaagaa actagcaagc tagtagcaga
     4621 ttgcccaaaa caccgctttg aggttgtaga taagactgac ctatataatc caaggtgaag
     4681 cgactgtggt ttgaagagat tttcaaagag tataggctag agagtagtgt ttttatgtcc
     4741 ttctagtaga aaatgctaga cagaagaatg gggaacttgg ataggaaaaa tagattgaga
     4801 aaggaggtta gaagagatga ttattacaaa aattagccgt ttaggaactt atgtgggagt
     4861 caatccacat tttgcaacat taatagattt tctagaaaaa acaggactag aaaatttaac
     4921 agaaggttcg attgctatcg atggtaatcg attgtttggg aattgcttta tttatctagc
     4981 agatggtcaa gcaggggctt tctttgaaac acaccaaaaa tatttggata ttcatttagt
     5041 tttggaaaac gaagaagcca tggctgttac atcgccggaa aatgtaagcg ttacccaaga
     5101 atatgatgaa gagaaagata ttgaattata cacagggaaa gtggaacagt tggttcattt
     5161 gagagctggt gaatgcctca tcacttttcc agaagattta catcaaccca aggttcgtat
     5221 aaatgatgaa cctgtgaaaa aagttgtctt taaagttgcg atttcttaat gtagaaagag
     5281 aagaacgatg aaaaaaatga gaaagttttt atgtctagct ggaattgcgc tagcggctgt
     5341 tgccttggta gcttgttcag gaaaaaaaga agctacaact agtactgaac caccaacaga
     5401 attatctggt gagattacaa tgtggcactc ctttactcaa ggaccccgtt tagaaagtat
     5461 tcaaaaatca gcagatgctt tcatgcaaaa gcatccaaaa acgaaaatca agattgaaac
     5521 attttcttgg aatgacttct atactaaatg gactacaggt ttagcaaatg gaaatgtgcc
     5581 agatatcagt acagctcttc ctaaccaagt aatggaaatg gtcaactcag atgctttggt
     5641 tccgctaaat gattctatca agcgtattgg acaagataaa tttaacgaaa ctgccttaaa
     5701 tgaagcaaaa atcggagatg attactactc tgttcctctt tattcacatg cacaagtcat
     5761 gtgggttaga acagatttgt taaaagaaca taatattgag gttcctaaaa cttgggatca
     5821 actctatgaa gcttctaaaa aattgaaaga agctggagtt tatggcttgt ctgttccgtt
     5881 tggaacaaat gacttaatgg caacacgttt cttgaacttc tacgtacgta gtggtggagg
     5941 aagcctctta acaaaagatc ttaaagcaga cttgacaagc caacttgctc aagatggtat
     6001 taaatactgg gttaaattgt ataaagaaat ctcacctcaa gattctttga attttaatgt
     6061 ccttcaacaa gctaccttgt tctatcaagg aaaaacagca tttgacttta actctggctt
     6121 ccatatcgga ggaattaatg ccaacagtcc tcaattgatt gattcgattg atgcttatcc
     6181 tattccaaaa atcaaagagt ctgataaaga ccaaggaatt gaaacctcaa acattccaat
     6241 ggttgtttgg aaaaattcaa aacatccaga agttgctaaa gcattcttag aagcacttta
     6301 taatgaagaa gactacgtta aattccttga ttcaactcca gtaggtatgt tgccaactat
     6361 taaggggatt agcgattctg cagcctataa agaaaatgaa actcgtaaga agtttaaaca
     6421 tgctgaagaa gtaattactg aagctgttaa aaaaggtact gctattggtt atgaaaatgg
     6481 accaagtgta caagctggta tgttgactaa ccaacacatt attgaacaaa tgttccaaga
     6541 tatcattaca aatggaacag atcctatgaa agcagcaaaa gaagcagaaa aacaattaaa
     6601 cgatttattt gaggctgttc agtagatgta aaagactaga aaataggtgg gctagtgatc
     6661 tgaaaagctc tagcccaatt ttgtaaaaga agggagaagg agaatggtta aagaacgtaa
     6721 tttaactcgc tggatatttg ttttgccagc tatgattatc gtaggattac tctttgttta
     6781 tccgtttttc tcgagtattt tttatagctt taccaataag catttgatta tgcctaatta
     6841 taaatttgtt ggtttggcta actataaagc tgtgctatca gatcccaact tctttaatgc
     6901 gttctttaat tcaattaagt ggaccgtttt ctcattagtt ggtcaagttt tagtagggtt
     6961 tgtgttggct ttagctcttc acagagtacg ccacttcaag aaattatata ggaccttatt
     7021 gattgttcct tgggcatttc ctaccatcgt tattgccttc tcttggcagt ggattctaaa
     7081 cggggtttat ggctacttac ctaatctaat cgtaaaatta ggtttaatgg aacatacacc
     7141 tgcatttttg acagatagta catgggcatt cctatgtttg gtgtttatca acatttggtt
     7201 tggagcacca atgattatgg ttaatgtgct ttcagctttg caaacagtac cagaagaaca
     7261 atttgaggct gctaagatag atggtgcttc aagttggcag gtgttcaagt ttatcgtctt
     7321 tccacatatt aaagtggttg taggacttct agttgttttg agaactgtat ggatctttaa
     7381 taactttgac attatctacc tcattactgg tggtggacca gccaatgcta caacgacgct
     7441 tccaattttt gcttacaacc tgggttgggg aactaaattg ttgggtcgtg cttcagcagt
     7501 tacagtattg ctctttatct tcttggtggc gatttgcttt atctactttg ctatcatcag
     7561 taagtgggaa aaggagggta gaaaataatg aagaagaaat ccggtattta tttagatatt
     7621 ctctcacatg tacttttagt tggtgcgacc atcgttgcag ttttcccatt ggtatggatt
     7681 atcatatctt ctgtcaaagg gaaaggggaa ttaactcagt atccaacacg attttggcct
     7741 gaacagttta cattagatta tttcactcat gttatcaacg atttgcactt cattgataac
     7801 attcgaaaca gtttaatcat tgccttggct acaaccctta ttgcgattat tatttctgct
     7861 atggcagcct atggtattgt tcgattcttt cctaaattgg gagcaatcat gtcgagacta
     7921 ctcgtcatta cctatatttt cccaccaatt ttgttagcaa ttccctattc aattgccatt
     7981 gctaaagttg ggttaacaaa tagtttattt ggcttgatga tggtttatct atcttttagt
     8041 gttccatatg cagtttggct cttagttgga tttttccaaa cagttccaat tggaattgaa
     8101 gaagcggcta gaattgatgg tgcaaataaa tttgttacgt tttataaagt tgtgctaccg
     8161 attgtagcac caggtattgt agcaacagct atttatacat ttatcaatgc ttggaatgaa
     8221 ttcctgtatg ccttgatttt gattaacaat acaggaaaga tgacagtagc agtagccctt
     8281 cgttcactta atggttcaga aatactagac tggggagata tgatggcagc gtctgttatt
     8341 gtagttcttc catcaattat tttcttctct atcatccaaa ataagattgc aagtggatta
     8401 tcagaaggat ctgtgaagta gacgaaagaa ggaaaaaaaa tgaataaaag aggtctttat
     8461 tcaaaactag gaatttctgt tgtaggcatt agtcttttaa tgggagttcc cactttgatt
     8521 catgcgaatg aattaaacta tggtcaactg tccatatctc ctatttttca aggaggttca
     8581 tatcaactga acaataagag tatagatatc agctctttgt tattagataa attgtctgga
     8641 gagagtcaga cagtagtaat gaaatttaaa gcagatgaac caaactctct tcaagctttg
     8701 tttggcctat ctaatagtaa agcaggcttt aaaaataatt acttttcaat tttcatgaga
     8761 gattctggtg agataggtgt agaaataaga gacgcccaaa agggaataaa ttatttattt
     8821 tctagaccag cttcattatg gggaaagcat aaaggacagg cagttgaaaa tacactagta
     8881 tttgtatctg attctaaaga taaaacatac acaatgtatg ttaatggaat agaagtgttc
     8941 tctgaaacag ttgatacatt tttgccaatt tcaaatataa atggtataga taaggcaaca
     9001 ctaggagctg ttaatcgtga aggtaaggaa cattacctcg caaaaggaag tattgatgaa
     9061 atcagtctat ttaacaaagc aattagtgat caggaagttt caaatattcc cttgtcaaat
     9121 ccatttcagt taattttcca atcaggagat tctactcaag ctaactattt tagaataccg
     9181 acactatata cattaagtag tggaagagtt ctatcaagta ttgatgcacg ttatggtggg
     9241 actcatgatt ctaaaagtaa gattaatatt gccacttctt atagtgatga taatgggaaa
     9301 acgtggagtg agccaatttt tgctatgaag tttaatgact atgaggagca gttagtttac
     9361 tggccacgag ataataaatt aaagaatagt caaattagtg gaagtgcttc attcatagat
     9421 tcatccattg ttgaagataa aaaatctggg aaaacgatat tactagctga tgttatgcct
     9481 gcgggtattg gaaataataa tgcaaataaa gccgactcag gttttaaaga aataaatggt
     9541 cattattatt taaaactaaa gaagaatgga gataacgatt tccgttatac agttagagaa
     9601 aatggtgtcg tttatgatga aacaactaat aaacctacaa attatactat aaatgataag
     9661 tatgaagttt tggagggagg aaagtcttta acagtcgaac aatattcggt tgattttgat
     9721 agtggctctt taagagaaaa acataatgga aaacaggttc ctatgaatgt tttctacaaa
     9781 gattcgttat ttaaagtgac tcctactaat tatatagcaa tgacaactag tcagaataga
     9841 ggagagagtt gggaacaatt taagttgttg cctccgttct taggagaaaa acataatgga
     9901 acttacttgt gtcctggaca aggtttagca ttaaaatcaa gtaacagatt gatttttgca
     9961 acatatacta gtggagaact aacctatctc atttctgatg atagtggtca aacatggaag
    10021 aaatcctcag cttcaattcc gtttaaaaat gcaacagcag aagcacaaat ggttgaactg
    10081 agagatggtg tgattagaac attctttaga accactacag gtaagatagc ttatatgact
    10141 agtagagatt ctggagaaac atggtcggaa gtttcgtata ttgatggaat ccaacaaact
    10201 tcatatggca cacaagtatc tgcaattaaa tactctcaat taattgatgg aaaagaagca
    10261 gtcattttga gtacaccaaa ttctagaagt ggccgtaagg gaggtcaatt agttgtcggt
    10321 ttagtcaata aagaagatga tagtattgat tggaaatacc actatgatat tgatttgcct
    10381 tcgtatggtt atgcctattc tgcgattaca gaattgccaa atcatcacat aggtgtactg
    10441 tttgaaaaat atgattcgtg gtcgagaaat gaattgcatt taagcaatgt agttcagtat
    10501 atagatttgg aaattaatga tttaacaaaa taaaggagaa aaacatggtt aaatacggtg
    10561 ttgttggagc agggtatttt ggagctgaat tggctcgcta catgcaaaaa aatgatggag
    10621 cagagattac tcttctctat gatccagata atgcagaggc gattgcagaa gaattgggag
    10681 caaaagtagc aagttcctta gatgagttgg tttctagcga tgaagtagac tgtgttatcg
    10741 tcgcaactcc aaataatctt cataaggaac cggttattaa ggctgcacag catggtaaaa
    10801 atgttttctg tgaaaaacca attgcgcttt cttatcaaga ttgtcgcgag atggtagatg
    10861 tgtgtaaaga aaacaatgta acctttatgg caggacatat tatgaatttc tttaatggtg
    10921 ttcatcatgc aaaagaactc attaatcaag gagttatcgg agacgttcta tattgtcata
    10981 cagctcgtaa tggttgggaa gaacaacaac cgtcagtatc atggaaaaaa attcgtgaaa
    11041 aatcaggtgg tcacttgtat caccacatcc atgaattgga ttgcgttcaa ttccttatgg
    11101 ggggcatgcc tgaaactgta accatgacag gtggaaatgt ggcccatgaa ggtgaacatt
    11161 tcggtgatga agatgatatg atttttgtca atatggaatt ttctaataag cgttttgctt
    11221 tgttagaatg gggttcagct tatcgttggg gtgaacatta tgtcttaatc caaggaagca
    11281 aaggtgccat ccgcttagac ttattcaact gtaaaggaac tcttaagcta gatgggcaag
    11341 aaagctattt cttgattcac gaatcgcaag aagaagatga tgatcggact cgtatctatc
    11401 atagtacaga gatggatgga gcaattgctt atggtaaacc aggtaaacgt actccattat
    11461 ggctatcatc tgtcattgat aaagaaatgc gctatctgca tgagattatg gaaggagctc
    11521 cagtatcaga agaatttgca aaacttttga caggtgaagc tgccctagaa gcaattgcta
    11581 ctgcagatgc ttgtacccag tctatgtttg aagatcgcaa agtaagattg tcagaaattg
    11641 taaaataaat tttggtattc tcctatctat aggtcgactt gctcctctga aagtactttt
    11701 agaggagctg tttgactttg ctagtttttg aaactgaaat ctattatact acaaactatt
    11761 gaaagcgttt taattttaag gtataataat ctcatagaaa taaagaaaag gaggaaagag
    11821 gatgccacag attagcaaag aagccttgat tgagcaaatc aaagatggaa tcatcgtttc
    11881 ttgtcaggct cttcctcatg aaccgcttta tacagaagtg ggaggggtga ttcccttgct
    11941 ggtcaaagcg gctgagcaag gtggagcagt cggtatccga gcaaacagtg ttcgcgatat
    12001 caaggaaatt aaggaagtca ctaaacttcc aatcattggg attatcaaac gtgattatcc
    12061 acctcaggaa ccctttatca cggctactat gaaagaagtt gatgaattgg cagaactgga
    12121 catcgaggtg attgctctgg attgtaccaa gcgtgaacgc tacgatggtt tggaaattca
    12181 agagttcatt cgtcaggtta aggagaaata tcctaatcag cttttgatgg ctgatactag
    12241 tatcttcgaa gaagggctag cagctgtaga agcaggaatt gactttgtcg gaacaacctt
    12301 atcaggctac acatcctaca gtccaaaagt agacggtcca gattttgaat tgattaagaa
    12361 actctgtgat gccggtgtag atgtcattgc agaaggaaaa attcatacac cagaacaagc
    12421 caaacaaatc cttgaatatg gagtgcgagg catcgttgtt ggtggcgcca ttactagacc
    12481 aaaagagatt acagaacgct tcgttgctag tcttaaataa gatgtgaggg ggagttttat
    12541 gtttaaagtt ttacaaaaag ttggaaaagc ttttatgtta cctatagcta tacttcctgc
    12601 agcaggtcta cttttgggga ttggtggtgc actttcaaac ccaaccacga tagcaactta
    12661 tccaatacta gacaatagta tttttcaatc aatattccaa gtaatgagct ctgcaggaga
    12721 ggttgtattc agtaatttgt cactacttct ctgtgtggga ttatgtattg gcttagcgaa
    12781 acgagataaa ggaaccgctg cgttagcagg agtaactggt tacttagtta tgactgcaac
    12841 gatcaaagct ttagtaaaac tttttatggc agaaggatct gcaattgata ctggagttat
    12901 tggagcatta gttgtcggaa tagttgccgt atatttgcac aaccgatata acaatattca
    12961 attaccttcc gctttaggat tctttggagg ttcacgcttc gttcctattg ttacatcgtt
    13021 ctcttctatc ttgattggct ttgtcttctt tgttatttgg ccacctttcc aacaacttct
    13081 tgtttctaca ggtggatata tttctcaggc gggtccaatt ggaacttttc tatatggatt
    13141 tttaatgaga ctttctggag cagtaggctt acatcatata atttacccta tgttttggta
    13201 tactgaactt ggtggtgttg aaactgttgc aggacaaaca gtggttggag ctcaaaaaat
    13261 attttttgct caattagccg atctggccca ttctggatta tttacagaag gaacaaggtt
    13321 ttttgcaggt cgtttctcaa caatgatgtt cggtttaccg gctgcctgtt tagcgatgta
    13381 ccatagtgtt cctaaaaatc gtcgtaaaaa atacgcgggt ttgtttttgg gagttgcttt
    13441 aacatctttt attaccggta ttacagaacc aattgaattt atgtttctat tcgtcagtcc
    13501 ggttctatat gttgttcacg cattccttga tggtgttagc ttctttattg cagacgtctt
    13561 aaatatttca ataggaaaca cattttcagg aggtgtaatc gatttcacat tatttggaat
    13621 tttgcagggg aacgctaaga cgaattgggt tcttcagatt ccatttggac ttatttggag
    13681 tgttttgtat tatattattt ttagatggtt cattactcaa ttcaacgttc taacgccagg
    13741 gcgaggagaa gaagtagatt ctaaagaaat ttctgaatcc gcagattcaa cttcaaatac
    13801 tgcagattat ttaaaacagg atagcctaca aattatcaga tccttgggtg gatcaaataa
    13861 tatagaagat gtagatgctt gtgtgacacg tttacgtgta gctgtaaaag aagttaatca
    13921 agttgataaa gcacttttaa aacaaattgg tgcagttgat gtcttagaag tgaagggtgg
    13981 cattcaagca atctatggag caaaagcaat cttatataaa aatagtatta atgaaatttt
    14041 aggtgtagat gattaagtac ttactgactt aataaaaaac agaggagagt gatggatgag
    14101 taggatgaaa tgaaatcgca tacaagaaat aaagaactca ttatccaagt tggatacgct
    14161 tattacatag gagaatacaa atgaaattta gaaaattagc ttgtacagta cttgcgggtg
    14221 ctgcggttct tggtcttgct gcttgtggca attctggcgg aagtaaagat gctgccaaat
    14281 caggtggtga cggtgccaaa acagaaatca cttggtgggc attcccagta tttacccaag
    14341 aaaaaactgg tgacggtgtt ggaacttatg aaaaatcaat catcgaagcg tttgaaaaag
    14401 caaacccaga tataaaagtg aaattggaaa ccatcgactt caagtcaggt cctgaaaaaa
    14461 tcacaacagc catcgaagca ggaacagctc cagacgtact ctttgatgca ccaggacgta
    14521 tcatccaata cggtaaaaac ggtaaattgg ctgagttgaa cgacctcttc acagatgaat
    14581 ttgttaaaga tgtcaacaat gaaaacatcg tacaagcaag taaagctgga gacaaggctt
    14641 atatgtatcc gattagttct gccccattct acatggcaat gaacaagaaa atgttagaag
    14701 atgctggagt agcaaacctt gtaaaagaag gttggacaac tgatgatttt gaaaaagtat
    14761 tgaaagcact taaagacaag ggttacacac caggttcatt gttcagttct ggtcaagggg
    14821 gagaccaagg aacacgtgcc tttatctcta acctttatag cggttctgta acagatgaaa
    14881 aagttagcaa atatacaact gatgatccta aattcgtcaa aggtcttgaa aaagcaacta
    14941 gctggattaa agacaatttg atcaataatg gttcacaatt tgacggtggg gctgatatcc
    15001 aaaactttgc caacggtcaa acatcttaca caatcctttg ggcaccagct caaaatggta
    15061 tccaagctaa acttttagaa gcaagtaagg tagaagtggt agaagtacca ttcccatcag
    15121 acgaaggtaa gccagctctt gaataccttg taaacgggtt tgcagtattc aacaataaag
    15181 acgacaagaa agtcgctgca tctaagaaat tcatccagtt tatcgcagat gacaaggagt
    15241 ggggacctaa agacgtagtt cgtacaggtg ctttcccagt ccgtacttca tttggaaaac
    15301 tttatgaaga caaacgcatg gaaacaatca gcggctggac tcaatactac tcaccatact
    15361 acaacactat tgatggattt gctgaaatga gaacactttg gttcccaatg ttgcaatctg
    15421 tatcaaatgg tgacgaaaaa ccagcagatg ctttgaaagc cttcactgaa aaagcgaacg
    15481 aaacaatcaa aaaagctatg aaacaatagt ccttagttat tctataaaaa gtagtttttt
    15541 aaagaaccta agagtgtata cccccttttc cctctacaca gatagtgtaa gaaaaggggg
    15601 cttttgttta aaatgtaaga aactgtcacg aaattaaaat gaagttctta cataagcgaa
    15661 tcataaaaaa tttcattttg attttaaaac agttcaagaa agtcaaaaaa ttattctatt
    15721 tgaaagagag gtgccgactg tgaaagtcaa taaaatccgt atgcgggaaa cagtgatttc
    15781 ctacgctttc ctagcaccag tattattctt ctttgtcatc tttgtgttgg ctccgatggt
    15841 gatgggcttc attacaagtt tctttaacta ctcaatgact aaatttgagt ttgtaggctt
    15901 ggataactat atccgtatgt ttaaagatcc tgtctttaca aaatctctga ttaacacagt
    15961 tattttggtt attggatctg taccagttgt tgttctattc tcactctttg tagcatctca
    16021 gacctatcat caaaatgtca ttgccagatc cttctaccgt ttcgtcttct tccttcctgt
    16081 tgtaacgggt agtgttgccg tgacagttgt ttggaaatgg atttatgacc cactatcagg
    16141 gattctaaac tttgtcctta agtcaagcca catcatcagc caaaacattt cttggttggg
    16201 agataaaaac tgggcattga tggcgattat gattattctc ttgaccactt cagttggtca
    16261 gcccatcatc ctttatatcg ctgccatggg gaatatcgac aattcactgg ttgaagcggc
    16321 gcgtgttgat ggtgcaactg agtttcaagt tttttggaag attaaatggc caagccttct
    16381 tccaacaact ctttatattg caatcatcac aacaattaac tcattccagt gtttcgcctt
    16441 gattcagctt ttgacatctg gtggtccaaa ctactcaaca agtaccttga tgtactacct
    16501 ttacgaaaaa gccttccaat tgacagaata cggctatgcc aacacaattg gtgtcttctt
    16561 ggcagtcatg attgctatcg taagctttgt tcaatttaaa gtacttggaa acgacgtaga
    16621 atactaaaga aaggagacag ctatgcaatc tacagaaaaa aaaccattaa cagcctttac
    16681 tgttatttca acaatcattt tgctcttgtt gactgtgctg ttcatctttc cattctactg
    16741 gattttgaca ggggcattca aatcacaacc tgatacaatt gttattcctc ctcagtggtt
    16801 ccctaaaatg ccaaccatgg aaaacttcca acaactcatg gtgcagaacc ctgccttgca
    16861 atggatgtgg aactcagtat ttatctcatt ggtaaccatg ttcttagttt gtgcaacctc
    16921 atctctagca ggttatgtat tggctaaaaa acgtttctat ggtcaacgca ttctatttgc
    16981 tatctttatc gctgctatgg cgcttccaaa acaagttgtc cttgtaccat tggtacgtat
    17041 cgtcaacttc atgggaatcc acgatactct ctgggcagtt atcttgcctt tgattggatg
    17101 gccattcggt gtcttcctca tgaaacaatt tagtgaaaat attcctacag agttgcttga
    17161 atcagctaaa atcgacggtt gtggtgagat tcgtaccttc tggagtgtag ccttcccgat
    17221 tgtgaaacca gggtttgcag cccttgcaat ctttaccttc atcaatactt ggaatgacta
    17281 cttcatgcaa ttggtaatgt tgacttcacg taacaatttg accatctcac ttggggttgc
    17341 gaccatgcag gctgaaatgg caaccaacta tggtttgatt atggcaggag ctgcccttgc
    17401 tgctgttcca atcgtcacag tcttccttgt cttccaaaaa tcctttacac agggtattac
    17461 tatgggagcg gtcaaaggat aatactctgc gaaaatcgaa tgcaaactac gtcagcttca
    17521 ccttgccata cttaagtatt gcttgcggtt agcttcctag tttgttcttc aattttcatt
    17581 gagtatagga aaatcaatct atcaagatac agaagtatat tttatagatt tagagaatat
    17641 ataagttata agtgtctaca aaatggaggg tatgcagtta ctttatgaag ttttgtcaga
    17701 cacttataaa cttaagaatg gttttagtta actatcagaa acgaaggaaa gagtatgatt
    17761 tttgacgatt tgaaaaacat caccttttac aaagggattc atcccaattt agacaaggct
    17821 atcgactacc tctaccaaca tcgtaaagat tcattcgaat taggaaagta tgagattgat
    17881 ggagataaag tctttctagt tgttcaggaa aatgtcctca atcaagttga gaataatcaa
    17941 tttgaacacc ataagaacta tgcagatttg catttgctga tagaagggca tgaatattcg
    18001 agctacggtt cacgtatcaa agacgaggca gtagcattcg acgaagcgag tgacattggc
    18061 tttgttcatt gtcatgaaca ctacccgctc ttgttgggtt atcacaattt tgcgattttc
    18121 ttcccaggtg agccacatca gccaaatggt tatgcaggca tggaagaaaa ggttcgaaaa
    18181 tatctcttta aaatcttgat tgattaaaaa taggatgaat tgtttttttg taaagctttg
    18241 ataatactct accatgaaat tgatctttgt gaggtagaga aatgagaata aaatatttaa
    18301 aaattggtat cttctaagta tgctgcaaga gctagtttct tagatggaca ggggattaca
    18361 gttgatgaga tgtcctggat aattaggggc attgtgaatg gattgattgg tagatacata
    18421 aaattaggta cttatgcagc taagtatggt attagtatgg cgcgctcgat cttaagtagg
    18481 gcagctgcaa ctgcggcagc aagagtaaga ttattgacta agatttttgg atggatttta
    18541 cgaatagctg tgctcgcagc tgatgtatat ggtaattttg ccaacaatat tgctgcagct
    18601 tgggatgcac atgataaaat ccctaacaat ggtcgtataa acttttaaaa tgcgagaatg
    18661 aaagcacttt gtattttttt attgtatatg ttagcttgga cagtgcttgc aatgataatc
    18721 cgtggagggc tagatggatt tgatgaacac acttggcgta atattttagc tagtgcgttg
    18781 tcctcgctat acatacatta tatatccata gataaaaata gaaaaaagtc caaaagaaaa
    18841 aagaaaaaat agatttgttc atggtaggga cttatgaaag ctttactgac aaaaaagaaa
    18901 acagtttaca aagaaaaatg atggaggagc aaacatggca caaaaaggag taagccttat
    18961 caaggcagca tttgatacag ataactttct catgcgtttt agtgagaagg tcttggacat
    19021 cgtgacagcc aatcttcttt ttgtcgtctc ttgtttgccc atcgtgacga ttggagtggc
    19081 taaaatcagc ctctacgaga ccatgttcga agttaagaag agcagacggg tgcctgtttt
    19141 taaaatctat ctaagatctt tcaagcaaaa tctgaaacta ggtcttcagt taggtctgct
    19201 tgagttgggc attgtttcat taagcctcct agatctttat ctcttttggg gtcaaacagc
    19261 tctgcccttt caattgctga aagctatttg tctaggcatt ctgattttcc ttacgattgt
    19321 gatgttggct agctatccaa tcgcggcacg ttatgattta acttggaaag aaattcttca
    19381 aaaaggattg atgttggcta gttttaactt tccttggttc ttcctcatgt tagccattct
    19441 tgtcctcatt gtgatggttc tttatctgtc tgccttcagt ctactcttag gtggctcagt
    19501 cttcctgctt tttgggtttg gactattggt ctttatccag actggattga tggagaaaat
    19561 tttcgcaaaa taccaatagg agccttattt ctgaaactac tttcaaaggc tccaaacgct
    19621 attctataag cgagaaacta aaatctaagt gtctataaga tattgaaagc cttttcggta
    19681 aagtgtatac taaagaagta aagaaaaatc tgctttagca gaaaataaaa ataataggag
    19741 aaaatctatg tcagatttga aaaaatacga aggtgtcatt ccagccttct acgcatgtta
    19801 tgatgagcaa ggagaagtaa gtccagagcg tacgcgtgcc ttggttcaat acttcattga
    19861 taaaggtgtt caaggtcttt atgtcaatgg ttcttctggt gaatgtatct accaaagcgt
    19921 tgaagatcgc aagttgattt tggaagaagt catggcggta gccaaaggta aattgaccat
    19981 tattgcccat gttgcttgca ataatactaa agatagtatg gaacttgctc gccatgctga
    20041 aagcttggga gtagatgcta ttgcaacgat tccaccaatt tacttccgct tgccagaata
    20101 ctcagttgcc aaatactgga acgatat
//
LOCUS       DAVHSO010000040        19941 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.040, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000040 DAVHSO010000000
VERSION     DAVHSO010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19941)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19941)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19941
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.040"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            356..1309
                     /locus_tag="VVR18_001435"
     CDS             356..1309
                     /locus_tag="VVR18_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU6032940.1"
                     /translation="MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGET
                     ELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIV
                     EELFTEEEITILEMGSGMGILGATFLTSLAKKVDYLGMEMDDLLIDLAASMADVIGLQ
                     AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGL
                     KYLKSDGYAIFLAPSDLLTSPQSDLLKEWLKEEASLVAMISLPENLFANANQSKTIFI
                     LQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI"
     gene            1360..2550
                     /locus_tag="VVR18_001436"
     CDS             1360..2550
                     /locus_tag="VVR18_001436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HEU6032941.1"
                     /translation="MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTV
                     KFDGRSEQQILDIENHTQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTV
                     VEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRY
                     PLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKA
                     GKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISHVLNRESGLLG
                     VSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKYIGQYLAVLNGADAIVFTAGVGE
                     NAENFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVE
                     RLKK"
     gene            2699..3070
                     /gene="rnpA"
                     /locus_tag="VVR18_001437"
     CDS             2699..3070
                     /gene="rnpA"
                     /locus_tag="VVR18_001437"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HEU6032942.1"
                     /translation="MKKNFRVKREKDFKAIFKEGTSFANRKFVVYQLENQKKHFRVGL
                     SVSKKLGNAVTRNQIKRRIRHIIQNAKGSLVEDVDFVVIARKGVETLGYAEMEKNLLH
                     VLKLSKIYREGNGSEKETKVD"
     gene            3045..3869
                     /locus_tag="VVR18_001438"
     CDS             3045..3869
                     /locus_tag="VVR18_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEU6032943.1"
                     /translation="MKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKSVYF
                     FAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYP
                     GRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFL
                     WINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAP
                     GGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK"
     gene            3888..4874
                     /locus_tag="VVR18_001439"
     CDS             3888..4874
                     /locus_tag="VVR18_001439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HEU6032944.1"
                     /translation="MVVFTGSTVEEAIQKGLKELDIPRMKAHIKVISREKKGFLGLFG
                     KKPAQVDIEAISETTVVKANQQVVKGVPKKINDLNEPVKTVSEETVDLGHVVNVIKKI
                     EEEGQGISDEVKAEILKHERHASTILEETGHIEILNELQIEEAMREEAGADDLETEQD
                     QTENQDLKEMGLKVEQSYDIAQVATDVTAYVQAIVDDMDVEATLSNDYNRRSINLQID
                     TNEPGRIIGYHGKVLKALQLLAQNYLYNRYSKTFYVTINVNDYVEHRAEVLQTYAQKL
                     AIRVLEEGRSHQTDPMSNSERKIIHRIISRMDGVTSYSEGDEPNRYVVVDTE"
     gene            4925..5548
                     /locus_tag="VVR18_001440"
     CDS             4925..5548
                     /locus_tag="VVR18_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P"
                     /protein_id="HEU6032945.1"
                     /translation="MLNKIRDYLDFSGLQYRSPDKAGAEREKMLAFRHKGQEARKAFT
                     ELVKAFQASHPEWQLQQTSQWMNQAQRLRPHFWVYLQRDGQVTEPMMALRLYGTSTDF
                     GISLEVSFIERKKDEQTLGKQANILDIPTVKGIYYLTYSNGQSQRWEANEEKRRTLRE
                     KVRSQEVRKVLVKVDVPMTENSSEEEIVEGLLKSYSKILPYYLATRK"
     gene            5679..7136
                     /locus_tag="VVR18_001441"
     CDS             5679..7136
                     /locus_tag="VVR18_001441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEU6032946.1"
                     /translation="MEVVSSVLNWFSSNILQNPAFFVGLLVLIGYALLKKPAHDVFSG
                     FVKATVGYMLLNVGAGGLVTTFRPILAALNYKFQIGAAVIDPYFGLAAANNKIAAEFP
                     DFVGTATTALLIGFGINILLVALRKITKVRTLFITGHIMVQQAATVSLMVLFLVPQLR
                     NAYGTAAIGIICGLYWAVSSNMTVEATQRLTGGGGFAIGHQQQFAIWFVDKVAGRFGK
                     KEESLDNLKLPKFLSIFHDTVVASATLMLVFFGAILLILGPDIMSNKEVITSGTLFNP
                     AKQDFFMYIIQTAFTFSVYLFVLMQGVRMFVSELTNAFQGISNKLLPGSFPAVDVAAS
                     YGFGSPNAVLSGFTFGLIGQLITIVLLIVFKNPILIITGFVPVFFDNAAIAVYADKRG
                     GWKAAVILSFISGVLQVALGALCVALLDLASYGGYHGNIDFEFPWLGFGYIFKYLGIV
                     GYVLVCLFLLVIPQLQFAKAKDKEKYYNGEVQEEA"
     gene            7159..7440
                     /locus_tag="VVR18_001442"
     CDS             7159..7440
                     /locus_tag="VVR18_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU6032947.1"
                     /translation="MVKVLAACGNGMGSSMVIKMKVENALRKLNQTDFTVNSCSVGEA
                     KGLAVGYDIVIASLHLIQELEGRTNGKLIGLDNLMDDKEITEKLSQALQ"
     gene            7518..8003
                     /locus_tag="VVR18_001443"
     CDS             7518..8003
                     /locus_tag="VVR18_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6032948.1"
                     /translation="MNLKQALIDNDSIRLGLEANDWKEAVKVAVDPLIESGAILPEYY
                     DAIIESTEEYGPYYILMPGMAMPHARPEAGVQSDAFSLITLQNPVVFSDGKEVSVLLA
                     LAATSSKIHTSVAIPQIIALFELEDSIARLQACQTKEDVLAMIEESKDSPYLEGLDLE
                     S"
     gene            8020..8685
                     /locus_tag="VVR18_001444"
     CDS             8020..8685
                     /locus_tag="VVR18_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-keto-L-gulonate-6-phosphate decarboxylase
                     UlaD"
                     /protein_id="HEU6032949.1"
                     /translation="MTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQV
                     GSELAEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALK
                     AIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNK
                     VKKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRGITEAADPAGAARAFKDEIRR
                     IWG"
     gene            8689..9552
                     /locus_tag="VVR18_001445"
     CDS             8689..9552
                     /locus_tag="VVR18_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000252119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 3-epimerase"
                     /protein_id="HEU6032950.1"
                     /translation="MVRPIGIYEKATPTHFTWLERLNFAKELGFDFVEMSIDERDERL
                     ARLDWSKEERLEVVKAIYETGVRIPSICFSGHRRYPLGSKDPVLEEKSLELMKKCIEL
                     AQDLGVRTIQLAGYDVYYEEKSPQTRQRFIKNLRKACDWAEEAQVVLAIEIMDDPFIN
                     SIEKYLAIEKELDSPFLFVYPDIGNVSAWHNDIYSEFYLGHHAIAALHLKDTYAVTES
                     SKGQFRDVPFGQGCVKWEEAFDILKETNYNGPFLIEMWSENCETVEETRAAIQEAQAF
                     LYPLIKKAGLM"
     gene            9554..10258
                     /locus_tag="VVR18_001446"
     CDS             9554..10258
                     /locus_tag="VVR18_001446"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HEU6032951.1"
                     /translation="MNQVINAMRKRVCDANQSLPKHGLVKFTWGNVSEVNRELGVIVI
                     KPSGVDYDELTPENMVVTDLDGKILEGDLRPSSDLPTHVQLYKAWSEIGSVVHTHSTE
                     AVGWAQAGRDIPFYGTTHADYFYGSIPCARSLTKDEVEVAYEKDTGLVIVEEFEHRGL
                     NPVEVPGIVVRNHGPFTWGKNPENAVYHSVVLEEVSKMNRFTEQINPRVEPAPQYILE
                     KHYQRKHGPNAYYGQK"
     gene            10435..12108
                     /locus_tag="VVR18_001447"
                     /pseudo
     CDS             10435..12108
                     /locus_tag="VVR18_001447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398040.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
     gene            12220..13311
                     /gene="ulaG"
                     /locus_tag="VVR18_001448"
     CDS             12220..13311
                     /gene="ulaG"
                     /locus_tag="VVR18_001448"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ascorbate 6-phosphate lactonase"
                     /protein_id="HEU6032952.1"
                     /translation="MPNVKEITRESWILATFPEWGTWLNEEIEEEVVPEGNFAMWWLG
                     NCGTWIKTPAGANVVMDLWSNRGKSTKKVKDMVRGHQMANMAGVRKLQPNLRVQPMVI
                     DPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKE
                     RIIVVKPGDTIELKDMKIHAVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKA
                     VNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNNYGENPVGIQDKMTSIDLLR
                     MAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQ
                     DQHLVEYHHPRGFDDCFEQDSNIQFKALL"
     gene            13425..15407
                     /gene="tkt"
                     /locus_tag="VVR18_001449"
     CDS             13425..15407
                     /gene="tkt"
                     /locus_tag="VVR18_001449"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000067869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEU6032953.1"
                     /translation="MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLH
                     INPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMDEIKSFRQWGSKTPGHPEF
                     GHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEG
                     VSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGT
                     DLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALG
                     WDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEAHPELAAEVEAIIDGRDP
                     VEVTPADFPALENGFSQATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQ
                     DDTNRLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGL
                     PVTYVFTHDSIAVGEDGPTHEPVEHLAGLRAMPNLNVFRPADARETQAAWYLAVTSEK
                     TPTALVLTRQNLTVEDGTDFDKVAKGAYVVYENAADFDTILIATGSEVNLAVAAAKEL
                     ASKGEKVRVVSMPSTDVFDKQDAAYKEEILPNAVRRRVAVEMGASQNWYKYVGLDGAV
                     LGIDTFGASAPAPKVLAEYGFTVENLVKVVRNLKQS"
     gene            15518..15817
                     /gene="yajC"
                     /locus_tag="VVR18_001450"
     CDS             15518..15817
                     /gene="yajC"
                     /locus_tag="VVR18_001450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEU6032954.1"
                     /translation="MNPNITFLIMLVGMMALMFFMQRSQKKQAQKRMESLNKLQKGYE
                     VITIGGLYGTVDEVDTEKGTIVLDVDGVYLTFELAAIKTVLPLKETASLEGAIEK"
     gene            15864..16292
                     /locus_tag="VVR18_001451"
     CDS             15864..16292
                     /locus_tag="VVR18_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase"
                     /protein_id="HEU6032955.1"
                     /translation="MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNP
                     IHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYIIGMDASNVSDLRQMCPVDCQDK
                     IYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES"
     gene            16294..16704
                     /locus_tag="VVR18_001452"
     CDS             16294..16704
                     /locus_tag="VVR18_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032956.1"
                     /translation="MENLTNFYEKYRVYLTRPRLELLAVVTIVFCAVLVFFLNIPGKG
                     VLKLDNGTIVYDGSLVRGKMNGQGTITFQNGDQYTGGFNNGAFNGKGTFQSKEGWTYE
                     GDFVNGQAEGKGKLTTEQEVVYEGTFKQGVFQQK"
     gene            17004..19655
                     /gene="adhE"
                     /locus_tag="VVR18_001453"
                     /gene_synonym="adhC"
     CDS             17004..19655
                     /gene="adhE"
                     /locus_tag="VVR18_001453"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HEU6032957.1"
                     /translation="MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDY
                     IVAKASVAALDAHGELALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEE
                     DDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHA
                     ARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGK
                     PALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAE
                     FKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKPATWIAEQAGFTVPE
                     GTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIH
                     TADEELTKEFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVS
                     AINLLNIKKVGRRRNNMQWMKLPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGF
                     LDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGGGSPMDA
                     AKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFA
                     VISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMA
                     SDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNASTIAGMAFANAFLGISHSMAH
                     KIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPA
                     STPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANP
                     RLPMVDHMQEIIEDAYYGYKERPGRRK"
BASE COUNT         6265 a         3582 c         4319 g         5775 t
ORIGIN      
        1 cttcataaat tttattgtat catatttttg tttcacagga agtctaataa ataaaaattc
       61 tttaaaattt tgttgggaaa atgggaaaag atataaatgg aaacttagta taacacttgg
      121 aaaactctgt aaaaatagta agtcaattca tgtcccgttt tttctctagg gaagttgggc
      181 ggctatattt atatgaccat ttgtcgtaat aaacatccct accaagggtc aatagaaata
      241 aattcaacga aacttttgct gtcagattta gatgcccaat ttgtcattta tactctttca
      301 tataggactt tctataagga tggaaaaaag aagggaaatt tgataagata ggaatatgga
      361 ttttgaaaaa attgaacaag cctataccta tttactagag aatgtccaag tcatccaaag
      421 tgatttggcg accaactttt atgacgcctt ggtggagcaa aacagcatct atctggatgg
      481 tgaaactgag ctaaaccagg tcaaagacaa caatcaggcc cttaagcgtt tagcactacg
      541 caaagaagaa tggctcaaga cctaccagtt tctcttgatg aaggctggac aaacagaacc
      601 cttgcaggcc aatcaccagt ttacgccaga tgctattgcc ttacttttgg tatttattgt
      661 ggaagagttg tttacagagg aggaaatcac tatccttgaa atgggttctg ggatgggaat
      721 tctaggcgct actttcttaa cctcgcttgc taaaaaagtg gattacttgg gaatggaaat
      781 ggatgatttg ctgattgatt tggcagctag tatggcagat gtaattggtt tgcaggctgg
      841 ctttgtccaa ggagatgccg ttcgtccaca aatgctcaaa gaaagcgatg tggtcatcag
      901 tgacttgcct gttggctatt atcctgatga tgccgttgcg tcgcgccatc aagttgcttc
      961 tagccaagaa catacttacg cccatcactt gctcatggaa caagggctta agtacctcaa
     1021 gtcagacgga tacgctattt ttctagctcc gagtgatttg ttgaccagtc ctcaaagtga
     1081 tttgttaaaa gaatggctga aagaagaggc gagtctggtt gctatgatta gtctgcctga
     1141 aaatctcttt gctaatgcca accaatctaa gactattttt atcctacaga agaaaaatga
     1201 aatagcagta gagccttttg tttatccact tgctagcttg caagatgcaa gtgttttaat
     1261 gaaatttaaa gaaaattttc aaaaatggac tcaaggtact gaaatataaa atagattttg
     1321 ttataatagt tgaaaacgct taaaaagggg tatcatgtta tgacaaaaac aattgcaatc
     1381 aatgcaggaa gttcaagttt gaaatggcaa ttatacttaa tgccagaaga aaaagtattg
     1441 gcgaaaggtt tgattgaacg tatcggtttg aaagattcaa tttcaactgt aaaatttgac
     1501 ggccgttctg aacaacaaat tttggatatc gaaaatcata cacaagctgt taaaatttta
     1561 ttggatgact tgattcgttt cgatattatc aaggcttatg acgagattac aggtgttggc
     1621 caccgtgttg tagcaggtgg agaatatttc aaagaatcaa cagttgttga gggagatgtt
     1681 ttagaaaaag ttgaagagtt gagtttgttg gctcctctac acaacccggc caatgcagca
     1741 ggtgttcgtg ccttcaagga attgttgcca gacattacca gtgtagttgt ttttgatact
     1801 tccttccaca caagtatgcc agagaaagct tatcgctacc ctctaccaac aaaatattac
     1861 acagaaaaca aggttcgtaa atacggtgct catggtacaa gtcaccagtt tgtagcagga
     1921 gaagctgcaa aactcttggg acgtccatta gaagacttga agttaattac ctgtcatatt
     1981 ggtaacggag gctcaattac agctgtgaaa gccggcaaat ctgtagacac ttctatgggg
     2041 ttcactcctc ttggtggtat tatgatggga acgcgtacag gggatattga tccagctatc
     2101 attccttatt taatgcaata tacagaggat tttaacacac cagaagatat cagtcatgtt
     2161 cttaaccgtg aatcaggtct tttgggagtt tctgctaatt ctagcgatat gcgcgatata
     2221 gaagcagctg tagcagaagg gaatcacgag gctagcttgg cttatgaaat gtatgttgac
     2281 cgtatccaaa aatatatcgg tcagtacctt gcagtgctaa atggagcaga tgccattgtt
     2341 ttcacagcag gtgtcggtga aaatgcagag aatttccgtc gtgatgtaat ctcagggatt
     2401 tcgtggtttg gttgtgatgt tgatgatgaa aagaatgtct ttggcgttac aggagacatc
     2461 tcaacagagg cagctaaaat ccgtgtcttg gttattccaa cagatgaaga attagtcatt
     2521 gcccgtgacg ttgaacgctt gaaaaaataa gtgaaactaa aaaaatattc aatacaagga
     2581 gttgggaaag ttatttttcc agcttctttt tctgatgaaa ttgtccaaaa ccttgctatg
     2641 attggctttt ttgaaaaata tggtataata gtagtaattt aatagatgga gttgagtttt
     2701 gaagaaaaac tttcgtgtaa aaagagagaa agattttaag gcgattttca aggaggggac
     2761 aagttttgct aatcgcaaat ttgtggtcta ccaattagaa aaccagaaaa aacattttcg
     2821 agtaggtcta tcagttagca aaaaactggg gaatgccgtc actagaaatc aaattaagcg
     2881 acggattcgg catattatcc agaatgcaaa agggagtctg gtagaagatg tcgactttgt
     2941 tgtcattgct cgaaaaggag tcgaaacctt gggatacgca gagatggaga aaaatctact
     3001 ccatgtatta aaattatcaa agatttaccg ggaaggaaat gggagtgaaa aagaaactaa
     3061 agttgactag tttgctagga ctgtctctgt taatcatgac agcctgtgcg actaatgggg
     3121 taactagcga tattacagcc gaatcggctg atttttggag taaatcggtt tacttctttg
     3181 cggaaatcat tcgcttttta tcgtttgata ttagtatcgg agtggggatt attctcttta
     3241 cggtcttgat tcgtacagtc ctcttgccag tctttcaggt gcaaatggtg gcttctagga
     3301 aaatgcagga agctcagcca cgcattaagg cgcttcgaga acaatatcca ggtcgagata
     3361 tggaaagcag aaccaaacta gagcaggaaa tgcgtaaagt atttaaagaa atgggtgtca
     3421 gacagtcaga ctctctttgg ccgattttga ttcagatgcc ggttattttg gccctgttcc
     3481 aagccctatc aagagttgac tttttaaaga caggtcattt cttatggatt aaccttggta
     3541 gtgtggatac aacccttgtt cttccgattt tagcagcagt attcaccttt ttaagtactt
     3601 ggttgtccaa caaagctttg tctgagcgaa atggcgctac gactgcgatg atgtatggga
     3661 ttccagtctt gatttttatc tttgcagttt atgcgccagg tggagtcgcc ctatactgga
     3721 cagtgtctaa tgcttatcaa gtcttgcaaa cctatttctt gaataatcca ttcaagatta
     3781 tcgcagagcg cgaggccgta gtacaggcac aaaaagattt ggaaaataga aaaagaaaag
     3841 ccaagaaaaa ggctcagaaa acgaaataaa taaggaggaa tctggtaatg gtagtattta
     3901 caggttcaac tgttgaagaa gcaatccaga aaggattgaa agaattagat attccaagaa
     3961 tgaaggctca tatcaaagtc atttctaggg agaaaaaagg ctttcttggt ctatttggta
     4021 aaaaaccagc ccaagtggat attgaagcga ttagtgaaac gactgttgtc aaagcaaatc
     4081 aacaggtagt aaaaggcgtt ccgaaaaaaa tcaatgattt gaacgagcct gtgaagacgg
     4141 ttagtgaaga aaccgttgac cttggtcatg tggttaatgt tattaaaaaa atagaggaag
     4201 aaggtcaagg tatttctgat gaagtcaagg ctgaaatctt aaaacatgaa agacatgcca
     4261 gcactatctt agaagaaact ggtcacattg agattttaaa tgaacttcaa atcgaggaag
     4321 cgatgaggga agaagcaggc gctgatgacc ttgaaactga gcaagatcaa actgaaaatc
     4381 aagacttgaa agagatgggc ttgaaggtcg agcaaagtta tgatattgcc caggtggcta
     4441 cggatgtgac tgcctatgtt caagcgattg tggatgacat ggatgttgaa gctacacttt
     4501 caaatgatta taaccgtcgt agcatcaatc tacaaattga caccaacgaa ccaggtcgta
     4561 ttatcggcta ccatggtaaa gtcttgaagg ccttgcaact gttggctcaa aattatcttt
     4621 acaaccgcta ttccaaaacc ttctacgtta caatcaatgt caatgattat gttgaacacc
     4681 gtgcagaagt cttgcagacc tatgcgcaaa aattggcgat tcgtgtttta gaagaaggac
     4741 gtagtcatca aacagatcca atgtcgaata gtgaacgcaa gattatccac cgtattattt
     4801 cacgtatgga tggcgtgacc agttactctg aaggtgatga gccaaatcgc tatgtcgttg
     4861 tagatacaga ataagtaaaa tcagggttga cctgattttt tgctagctag aggaggttaa
     4921 actgatgttg aataagataa gagactatct agacttttct ggtttgcagt accgtagtcc
     4981 tgataaagcg ggagcagagc gagagaagat gctggcgttc cgccacaaag gacaagaggc
     5041 ccgaaaggct tttacagaac tggtcaaagc ctttcaagca agccatccag aatggcaact
     5101 ccaacagact agtcagtgga tgaatcaggc ccagcgtttg agaccacatt tttgggttta
     5161 tctacagaga gacggacaag tgacagaacc tatgatggcc ttacgtttgt atgggacatc
     5221 tactgacttt ggaatttctt tggaagtcag tttcatcgaa cgtaagaagg atgagcaaac
     5281 actgggcaag caggccaata ttttagacat tccaaccgtt aaagggattt attatctaac
     5341 ctactctaat ggtcaaagtc aacggtggga ggcgaatgaa gaaaagcgtc gtactttacg
     5401 cgagaaggtg agaagtcaag aagttcgaaa agttttagtg aaggtagatg ttcctatgac
     5461 agaaaattcg tctgaagaag aaatcgtaga aggcttattg aagtcttatt ctaaaattct
     5521 tccctattat ctagctacga gaaaataaga taatttgtaa aacatcataa atcatacagt
     5581 ccaagagtga acagtccgct gtgtaattct tggtcttttt gtttgcgctt tcgcattata
     5641 taataaactt acaaaaacaa ttcaaaagga gaacaattat ggaagtcgtt tcaagtgttc
     5701 taaattggtt ttctagcaat attttgcaga atcccgcatt tttcgtaggt ttattggtgt
     5761 tgataggata tgcacttttg aaaaaacctg cccatgacgt tttttcaggg tttgttaaag
     5821 caacagtagg gtatatgttg cttaacgtgg gtgctggtgg tttggttaca acctttcgtc
     5881 caatcttagc agctcttaac tacaaattcc aaattggtgc agcggttatc gacccttact
     5941 ttggacttgc tgcagcaaac aacaaaattg cagcagagtt tccagatttt gttggaactg
     6001 caactacagc tctattgatt ggtttcggaa taaatatctt gctcgtagct cttcgaaaga
     6061 ttacgaaggt aagaaccctc tttattactg gtcacatcat ggtacaacaa gctgcaacag
     6121 tatctcttat ggttctattc ttagtaccac aattgcgcaa tgcttacggt acagcagcga
     6181 ttggtatcat ctgtggactt tactgggcag ttagttcaaa tatgactgtt gaggcaactc
     6241 aacgcttgac tggtggtggc ggatttgcga ttggtcacca acagcaattt gcaatctggt
     6301 ttgtagataa agtagcagga cgctttggta agaaagaaga aagtttagac aatcttaaat
     6361 tacctaagtt cctctcaatc ttccacgata cagttgttgc atctgctacc ttgatgctcg
     6421 tattcttcgg ggccattctt ttaatcttgg gtccagacat tatgtctaat aaagaagtca
     6481 tcacttcagg aactctattc aatcctgcta aacaagattt ctttatgtac attatccaaa
     6541 cagcctttac cttctcagtt tacttgttcg ttttgatgca aggtgtccga atgttcgtat
     6601 ctgagttaac aaacgctttc caaggtattt caaacaaatt gttgccaggt tcattcccag
     6661 cggttgacgt tgcagcttct tatggatttg gttctccaaa tgctgtcttg tcaggattta
     6721 cctttggttt gattggtcaa ttgattacaa ttgtcttgct catcgtcttt aaaaatccga
     6781 ttcttattat tacaggattt gtaccagtgt tctttgacaa tgcagccatt gcggtctacg
     6841 ctgataaacg cggcggatgg aaagcggctg ttatcctttc ctttatatca ggtgtccttc
     6901 aagttgctct aggagctctt tgtgtggccc ttctcgattt ggcatcttat ggtggctacc
     6961 atggaaatat cgactttgaa ttcccatggc ttggatttgg atatatcttc aaataccttg
     7021 gtattgttgg ttatgtactt gtgtgtctct tcttgcttgt tattcctcaa cttcaatttg
     7081 ccaaagcaaa agataaagag aaatattaca acggtgaagt tcaagaagaa gcttagtatc
     7141 tagaaaagga gaaataaaat ggttaaagta ttagcagcgt gcggaaatgg aatgggttca
     7201 tcaatggtta tcaagatgaa ggttgaaaat gctctccgta agcttaatca aacagatttt
     7261 acagtcaatt catgcagtgt cggtgaagct aaaggtttag cagtaggata tgacatcgta
     7321 atcgcttctc ttcatttgat tcaagaattg gaagggcgaa ctaatgggaa gttaattggg
     7381 cttgataact tgatggatga taaagaaatc accgaaaaac tcagtcaagc actacagtaa
     7441 aaggttggag gggggctgga cagaaactga gagttatcgt ttctgtcctt ctccctcttt
     7501 aaataaagga ggcagatatg aatttaaaac aagctttaat tgacaacgac tcgatccgac
     7561 taggtttaga ggctaacgat tggaaagaag cagtcaaggt agcagtagat cccttgattg
     7621 aaagtggggc aattttgcca gagtattacg atgctatcat tgaatcgact gaagagtatg
     7681 ggccttacta tatcttgatg ccaggtatgg ctatgcccca cgctagacct gaagcaggtg
     7741 tgcaaagtga tgccttttca ttgattacct tacaaaatcc tgttgtattt tcagatggga
     7801 aagaggtatc tgttttgttg gcactagcag caacaagttc aaaaattcac acaagtgtag
     7861 ccattccaca aattattgcc ctatttgaat tagaagattc tattgcacgt ttacaggctt
     7921 gccagactaa agaagatgtc ttggctatga ttgaagaatc taaggatagc ccttatctcg
     7981 aaggattgga tttggaaagt tagaaagagg aataaagaaa tgacaaaaag aatacctaat
     8041 ttacaagttg cattagacca ttcagacttg caaggagcga ttaaagcagc tgtttctgtt
     8101 ggtcaggaag tagatattat cgaagctgga actgtttgct tgcttcaagt tggaagtgaa
     8161 ctggctgaag tcttgcgtag ccttttccca gataagatta ttgtggcaga cacaaaatgt
     8221 gctgatgctg gtggaacagt tgctaaaaat aatgcggttc gtggagcaga ctggatgact
     8281 tgtatctgtt gtgcaaccat ccctactatg gaagcagctc taaaggctat caagactgaa
     8341 cgaggagaac gaggcgaaat ccagatcgag ctttatggcg attggacttt tgaacaagct
     8401 cagctttggc tagatgcagg tatctcacaa gctatttatc accaatctcg tgatgctctt
     8461 cttgctggtg aaacttgggg tgaaaaagac cttaataagg ttaaaaaact cattgacatg
     8521 ggcttccgtg tatctgtaac aggtggtcta gatgtagata ctctcaaact ctttgaaggt
     8581 gttgatgtct ttacctttat cgcaggtcgt ggaattacag aggctgcgga tccagcagga
     8641 gcagcgcgtg ccttcaagga tgaaatcaga cgaatttggg ggtaaatcat ggtacgtcca
     8701 attggaattt atgaaaaggc aaccccaaca cactttactt ggctagaacg tttaaatttt
     8761 gccaaggagt taggctttga ttttgtcgag atgtctattg acgaacgtga cgagcgttta
     8821 gcaagacttg actggagtaa ggaagaacgc ttggaagttg tcaaagcaat ctatgaaact
     8881 ggtgttcgta ttccttctat ctgtttttca ggccatcgtc gctacccatt gggttcaaaa
     8941 gatccagttc tagaggaaaa atctctagaa ctcatgaaaa aatgtatcga attagctcaa
     9001 gacttgggag ttcgtacgat tcaattagct ggttacgatg tttactatga ggaaaagtca
     9061 ccccagacac gccaacgttt tatcaaaaat ttgagaaaag cctgtgactg ggctgaagaa
     9121 gctcaggtgg tacttgctat tgaaattatg gatgatcctt tcatcaatag catcgaaaaa
     9181 tatttggcta tagaaaaaga gcttgactct cccttcctct ttgtatatcc agatattggt
     9241 aatgtgtctg catggcataa tgatatctat agtgagtttt atcttggtca tcatgccatc
     9301 gcagctctcc atctcaagga tacttatgca gtgacagaaa gttcaaaggg ccagttccga
     9361 gatgtacctt ttgggcaagg ttgtgtcaaa tgggaagaag ctttcgatat tttaaaggaa
     9421 accaattata atggaccttt cctaatcgaa atgtggtctg aaaattgtga aacagtagaa
     9481 gaaacacgcg cagccattca agaggcgcaa gctttcctct atccactcat taagaaagca
     9541 ggtttgatgt aagatgaatc aagtaatcaa tgctatgcgt aaacgagtct gtgatgccaa
     9601 tcaatcattg ccaaaacatg gacttgtcaa atttacctgg ggcaatgtat cggaagtcaa
     9661 tcgcgaactc ggtgtcattg ttatcaaacc atcaggcgtg gattatgacg aattgacacc
     9721 tgaaaacatg gtagtgactg atctagatgg taagatccta gaaggggatt taagaccatc
     9781 ttccgacctc ccaactcatg tgcaattata taaggcttgg tcagaaattg gtagtgtggt
     9841 tcacacccat tcgacagaag ctgttggttg ggctcaggca ggtcgtgata ttcctttcta
     9901 cggaacaacc catgcagatt atttctacgg ttcaatccct tgcgcccgta gtttgaccaa
     9961 ggatgaagta gaagtggcct atgaaaaaga tactggcctg gttatcgtag aagagtttga
    10021 acatcgcgga cttaacccgg ttgaagtacc aggaattgtt gtacgcaatc acggtccatt
    10081 cacctggggc aaaaatccag agaatgctgt ttatcactct gtcgtactag aggaagtatc
    10141 aaagatgaat cgctttacag aacaaatcaa tccaagagtt gaacctgctc cccagtacat
    10201 actagaaaaa cactaccaac gtaaacatgg accaaatgct tattatggtc aaaagtaaga
    10261 acgacgaagg aggagaaaaa gataaattta gctcctcttt ttacatttga tttttattga
    10321 gagtaaagtt ggagttgaag taattttgaa agatttttta gaaatagcgc ttgatatata
    10381 tggtaaaata aaaagaattg ctgtgatatc aatagatttg ggggattttt taatatggta
    10441 ctggataagg caagttgtga tttgcttcaa tatttgatgg atcaagaaac gtccaaaacg
    10501 attatggcga tttcgaaaga tttgaaagag tcaagaagga aaatttatta tcacattgac
    10561 aaaatcaatg ctgctctggg tgacgaggcg cttcacatca ttagtattcc acgaattggt
    10621 attcacttaa cggaagagca gagagatgct tgttgtaaac tattatcgga agtagattcg
    10681 tacgattata tcatgagtgc gcatgaacgt atgatgataa tgttactatg gataggtatt
    10741 tctaaagaac gtattacgat tgaaaaattg atagagttaa cagaggtatc taggaatact
    10801 gttctcaatg atttgaatag tattcgttat caactaactt tggaacaata tcaggtgacc
    10861 ttgcaagtga gcaagtcaca gggatagcac cttcatgccc accctcttaa taaaattcag
    10921 tatcttcaat cgcttctata tcatattttt atggaagaaa atgccacttt tgtatctatt
    10981 ttagaagata agatgaaaga gaggttagat gatgagtgtt tgctttctgt tgaaatgaac
    11041 caatttttta aggaacaggt tcctttagtt gaacaagatt tagggaagaa aataaaccat
    11101 catgaaataa cttttatgtt gcaggttcta ccttatttgc tgttaagctg tcataatgtt
    11161 gaacagtatc aagaaagaca tcaggatata gagaaagaat tttctttgat aagaaaaaga
    11221 atagagtatc aggtgtctaa gaaattagga gaacggttgt ttcaaaagtt tgaaatttct
    11281 ttgtcaggac ttgaagtttc tcttgtagct gttctcctcc tctcctatcg taaagatttg
    11341 gatattcatg cagaaagtga tgattttcgg caattaaaac ttgctttaga agaatttatc
    11401 tggtattttg aatcacaaat ccgaatggag attgagaaca aggatgattt gttacgaaat
    11461 ttgatgatcc actgtaaagc cttgttattt agaaagactt acggtatttt ttctaaaaat
    11521 cctctaacaa aacaaattcg atccaagtat ggagaattat ttttagtcac tagaaaatct
    11581 gcggaaattt tagaaggagc atggtttatt cggctaacag acgatgatat tgcctatttg
    11641 acgattcata ttggaggatt tttaaaatat acaccatcgt ctcaaaaaaa tatgaaaaaa
    11701 gtttatctcg tttgtgatga aggtgttgcg gtttcgagac ttttgctgaa acaatgcaaa
    11761 ctttattttc caaatgagca aattgacact gtatttacaa cagaacaatt taagagtgtg
    11821 gaagatattg cacaagttga tgtagtgatt actactaatg atgatttgga tagcagattt
    11881 ccgattttaa gggttaatcc tatccttgaa gcagaagata ttttgaaaat gctagactat
    11941 cttaaacaca atatatttcg taataagagc aaaagtttca gtgaaaatct ttctagtctt
    12001 atttcgtctt atattgtaga cagcaagttg gctagtaagt tccaagaaga ggttcaaaca
    12061 cttataaatc aagaaatagt agttcaagct tttttggaag atatttgaag gacagtccaa
    12121 tgatgaacac aaacctgtgt ttttcttggt cttttttagt gttttgaagg gtggtatact
    12181 aatctcaaag ataacaatta tatccaaagg aggcaacata tgccaaacgt caaagaaatt
    12241 acaagagagt catggatttt agccactttc ccagagtggg gaacatggtt gaacgaagaa
    12301 atcgaagaag aagtcgtacc tgaaggcaac tttgccatgt ggtggctagg caactgtggt
    12361 acttggatta agacaccagc tggtgctaac gttgtcatgg acctttggtc aaaccgtgga
    12421 aaatcaacca aaaaagtgaa agatatggtt cgtgggcacc aaatggcaaa tatggcaggt
    12481 gttcgtaagt tgcaaccaaa cttgcgtgtt cagccaatgg ttatcgatcc atttgctatc
    12541 aacgaactag actattactt agtttcacac ttccacagtg atcatatcga cccatacaca
    12601 gctgcagcaa ttctcaacaa tcctaagtta gagcatgtta agtttatcgg tccttaccac
    12661 tgtggacgaa tctgggaagg atggggggtt ccaaaagaac gtatcatcgt tgttaaacca
    12721 ggtgacacta tcgaattaaa agatatgaag attcatgcag tagaatcatt tgaccgtact
    12781 tgcttggtaa ctctcccagt gaacggtgct gatgagacag gcggtgaact tgctggcttg
    12841 gctgttacag atgaagaaat ggctcaaaag gctgttaact atatctttga aacaccaggt
    12901 ggaaccatct atcatggtgc agattctcac ttctcaaact attttgcaaa acatggtaaa
    12961 gactttaaaa ttgatgttgc tttgaataac tatggtgaaa atccggtagg tatccaagac
    13021 aaaatgacat ctatcgacct tcttcgtatg gcagaaaatc tgcgtaccaa agtcattatc
    13081 ccagttcact atgatatctg gtctaacttc atggcttcta ctaatgagat tctagaactt
    13141 tggaaaatgc gaaaagatcg cttgcaatac gatttccatc catttatctg ggaagttggc
    13201 ggtaagtaca cttatcctca agatcaacac ttagtagaat accatcatcc acgtggtttt
    13261 gatgattgtt ttgaacaaga ctctaacatt caatttaaag ctttgctata atataaaaat
    13321 attctttgga ggttatccgt atgttgcatg atacggataa ttttcatata atagtaaaat
    13381 agaatgtgtg attcaataat cacctcaaat agaaaggaaa ttctatgtca aatctatctg
    13441 ttaatgcaat tcgttttcta ggtattgacg ccattaataa agccaactca ggtcatccag
    13501 gtgtggttat gggagcggct ccgatggctt acagcctctt tacaaaacaa cttcatatca
    13561 atccagctca accaaactgg attaaccgcg accgctttat tctttcagca ggtcatggtt
    13621 caatgctcct ttatgctctt cttcaccttt ctggttttga agatgtcagc atggatgaga
    13681 ttaagagttt ccgtcaatgg ggttcaaaaa caccaggtca cccagaattt ggtcatacgg
    13741 cagggattga tgctacgaca ggtcctctag ggcaagggat ttcaactgct actggttttg
    13801 cccaagcaga acgtttcttg gcagccaaat ataaccgtga aggctacaat atctttgacc
    13861 actatactta cgttatctgt ggagacggag acttgatgga aggtgtctca agcgaggcag
    13921 cttcatacgc aggtttgcaa aaacttgata agttggttgt tctttatgat tcaaatgata
    13981 tcaacttgga tggtgagaca aaggattcct ttacagaaag tgttcgtgac cgttacaatg
    14041 cctacggttg gcatactgcc ttggttgaaa atggaacaga cttggaagcc atccatgctg
    14101 ctatcgaaac agcaaaagct tcaggcaagc catctttgat tgaagtgaag acggttattg
    14161 gatacggttc tccaaacaaa caaggaacta atgctgtaca cggcgcccct cttggagcag
    14221 atgaaactgc atcaactcgc caagccctcg gttgggacta cgaaccattt gaaattccag
    14281 aacaagtata tgctgatttc aaagaacatg ttgcagaccg tggcgcatca gcttatcaag
    14341 cttggactaa attagttgca gattataaag aagctcatcc agaactggct gcagaagtag
    14401 aagccatcat cgacggacgt gatccagtcg aagtgactcc agcagacttc ccagctttag
    14461 aaaatggttt ttctcaagca actcgtaatt caagtcaaga tgccttgaat gttgtggcag
    14521 ctaaattacc aaccttccta ggtggatcag ctgaccttgc tcactcaaac atgacttata
    14581 tcaagacgga tggacttcaa gacgatacca atcgcttgaa tcgtaacatt cagtttggtg
    14641 ttcgtgaatt tgcaatggga acaatcttga acgggatggc ccttcatggt ggacttcgtg
    14701 tatacggtgg aactttcttc gtcttctctg actatgtgaa ggcagctgtc cgcttgtcag
    14761 ccttacaagg acttcctgtg acttatgtct ttacccatga ttcaatcgca gttggggaag
    14821 atggtccgac tcacgaacca gttgagcatt tagcaggtct tcgtgctatg ccaaatctaa
    14881 atgttttccg tccagcagat gcgcgtgaaa cgcaagcagc ttggtacctt gcagtgacaa
    14941 gtgagaaaac accaactgcc cttgtcttga cacgtcaaaa cttgactgtt gaagatggaa
    15001 cagacttcga caaggttgct aaaggtgctt atgttgtata tgaaaatgca gccgactttg
    15061 ataccatctt gattgcgaca ggttcagagg tcaatctagc tgtcgcagct gccaaagaat
    15121 tagctagtaa aggcgaaaaa gtccgcgtag ttagcatgcc atctacagat gtctttgata
    15181 aacaagatgc agcttacaag gaagagattc ttccaaatgc agtccgccgt cgtgttgcag
    15241 tcgaaatggg tgcaagtcaa aactggtaca aatatgttgg tctcgatggt gccgttctag
    15301 gtattgatac cttcggagcc tctgccccag caccaaaagt attggcagaa tatggcttta
    15361 ctgtagaaaa tcttgtaaaa gttgttcgaa acttgaaaca atcctaaaaa tcagggcgta
    15421 agctctggtt tttcttacca gaaaagtaag gtacaatctt gtaaaagtag ctgaaatttg
    15481 atatagtagt cctatgtaaa agacaaagga gaaaacaatg aatccaaata ttactttttt
    15541 aatcatgctt gtaggtatga tggccttgat gttctttatg caacgctctc aaaagaaaca
    15601 agcacaaaaa cgtatggaaa gcttaaataa actacaaaaa ggctatgaag tgattacaat
    15661 cggtggactt tatggaacag tcgatgaagt agatacggag aagggaacaa tagttcttga
    15721 cgtagatgga gtttacttga cttttgaact agctgctatc aagacagtat taccgctgaa
    15781 agaaacagct tcactagaag gcgcaattga aaaataagaa gggatcacga actcccgttt
    15841 ttctataaaa gaaaggaaat gggatgaaaa aattagtctt tgtctgtctg ggaaatattt
    15901 gccgtagccc tatggccgag tttgttatga aatcaatgac agataactac gaaatccaaa
    15961 gtcgagcaac ttcctcttgg gaacatggca atccgattca taaggggact cagggaattt
    16021 ttcaagagta tgagattcct tatgacaaga acaagacatc gcttcagatt agtaaggaag
    16081 attttgaagc ctttgattat attatcggaa tggacgcttc aaatgtttcc gacttacgtc
    16141 agatgtgtcc agtagactgt caagataaga tttactcatt ttcatctgaa agtgttccag
    16201 acccttggta tacaggagat tttgaagaaa cctatcgacg tgttcaagag ggctgtcaag
    16261 cttggttaga acgtttagaa aaggagagtt aaggtggaaa atcttacgaa tttttacgaa
    16321 aagtatcgtg tctatctgac tcgtccacgt ttagagcttt tggcagtagt taccattgtt
    16381 ttctgtgctg tactcgtctt ttttctaaat attccaggaa aaggtgtctt aaaactcgat
    16441 aatggaacga ttgtttatga tggcagtctt gtccgtggta aaatgaatgg ccaaggtacc
    16501 attaccttcc aaaatggaga ccaatataca ggtggcttca acaatggagc cttcaacgga
    16561 aaaggtacct ttcaatctaa agaaggctgg acctacgaag gtgattttgt aaatggtcag
    16621 gctgaaggaa aagggaaact aacaacagaa caagaagtcg tttatgaagg aacttttaaa
    16681 caaggcgttt ttcaacaaaa ataaagcctc cttatcaaag gaggtattat tagaattaca
    16741 aggtaagcgc ttacctgtaa atccctttct ttccaaatcc ctcttccaag caagtttgtg
    16801 aaataaaaaa tatttgaaat aaatttcaca aacttcaaag ataaaacctg ataagaaaag
    16861 aaaatgagaa aagtttcaca agagtttaaa aattctttgt gaaatgttta tgaaactgtt
    16921 tacaaagttg aaataatgcg ttataataaa cttgtgaaaa aattaacaaa ggatatcgtt
    16981 ccttgaaagc tatggaggaa aatatggctg ataaaaaaac tgtgacacca gaggaaaaga
    17041 aactcgttgc tgaaaaacac gtagatgagt tggttcaaaa agctctagtt gcccttgaag
    17101 aaatgcgtaa attggatcaa gagcaagttg actacatcgt tgccaaagca tcagtagcag
    17161 ctttggatgc ccacggagaa ttggctttac atgcctttga agaaacagga cgtggtgtat
    17221 ttgaagataa agcaactaag aacttgtttg cctgtgaaca cgtagtaaac aacatgcgcc
    17281 acactaagac agttggcgtt atcgaagaag acgatgtaac aggattgact cttattgctg
    17341 aaccagttgg tgttgtttgt ggtattactc caacaacaaa cccaacatca acagcaatct
    17401 tcaaatcatt gatttcattg aagacacgta acccaatcgt ctttgccttc catccatcag
    17461 cacaagaatc atctgctcat gcagctcgta tcgtccgcga tgcagctatc gcagctggtg
    17521 ctcctgaaaa ctgtgtgcaa tggattactc aaccatctat ggaagcaaca agtgccctta
    17581 tgaaccacga aggtgttgcg acaatccttg caacaggtgg taatgccatg gttaaggcag
    17641 cttattcatg tggtaaacca gctcttgggg taggtgccgg aaacgttcca gcttatgttg
    17701 aaaaatcagc aaacattcgt caagcagcac acgatatcgt catgtctaaa tcatttgata
    17761 acggtatggt ctgtgcatct gaacaagcag ttatcattga taaagaaatt tacgatgaat
    17821 ttgtagcaga gttcaaatct taccacactt actttgtaaa caaaaaagaa aaggctcttc
    17881 ttgaagagtt ctgcttcggc gtcaaagcaa acagcaaaaa ctgtgctggt gcaaaattga
    17941 acgctgacat cgttggtaaa ccagcaactt ggattgcaga acaagcagga tttacagttc
    18001 cagaaggaac aaacattctt gctgcagaat gtaaagaagt tggcgaaaat gagccattga
    18061 ctcgtgaaaa attgtcacca gttattgcag ttttgaaatc tgaaagccgt gaagatggta
    18121 ttactaaggc tcgtcaaatg gttgaattta acggtcttgg acactcagca gctatccaca
    18181 cagctgacga agaattgact aaagaatttg gtaaagctgt taaagctatt cgtgttatct
    18241 gtaactcacc ttctactttt ggtggtatcg gggacgttta caatgccttc ttgccatcat
    18301 tgacacttgg atgtggttct tacggacgca actcagttgg ggataacgtt agtgccatta
    18361 acctcttgaa tatcaaaaaa gtcggaagac ggagaaataa catgcaatgg atgaaacttc
    18421 cttcaaaaac atactttgaa cgtgattcaa ttcaatacct tcaaaaatgt cgtgacgttg
    18481 aacgtgtcat gatcgttact gaccatgcca tggtagagct tggtttcctt gatcgtatca
    18541 tcgaacaact ggaccttcgt cgcaataagg ttgtttacca aatctttgcg gatgtagaac
    18601 cggatccaga tatcacaact gtaaaccgtg gtactgagat tatgcgtgcc ttcaaaccag
    18661 ataccatcat cgcactcggt ggtgggtctc caatggatgc tgccaaagta atgtggctct
    18721 tctacgagca accagaagtg gacttccgtg accttgtcca aaaattcatg gatatccgta
    18781 aacgtgcctt caagttccca ttgcttggta agaagactaa attcatcgcg attccaacta
    18841 catctggtac aggatctgaa gtaacaccat ttgccgttat ctctgataaa gcaaacaacc
    18901 gtaaataccc aatcgctgac tactcattga caccaactgt ggcaatcgta gatcctgctt
    18961 tggtattgac agttccagga tttgttgctg ctgatactgg tatggacgta ttgactcacg
    19021 cgacagaagc atacgtatca caaatggcta gtgactacac tgatggttta gcacttcaag
    19081 ccattaaatt ggtctttgaa aatctcgaaa gctcagttaa gaatgctgac ttccactcac
    19141 gtgagaaaat gcataacgct tcaacaatcg ctggtatggc ctttgccaat gccttcctag
    19201 gtatttctca ctcaatggcc cataagattg gtgcgcaatt ccacacaatc cacggtcgta
    19261 caaatgctat cttgcttcca tacgttatcc gttacaacgg tacacgtcca gctaagacag
    19321 caacatggcc taagtacaac tactaccgtg cagatgaaaa ataccaagat atcgcacgca
    19381 tgcttggact tccagcttct actccagaag aaggggttga atcttacgca aaagctgtct
    19441 acgaactcgg tgaacgtatt gggatccaaa tgaattttag agaccaagga attgacgaaa
    19501 aagaatggaa agaacattct cgtgaattag ccttcctggc ttatgaagac caatgttcac
    19561 cagctaaccc acgtcttcca atggtagatc atatgcaaga aatcatcgaa gatgcatact
    19621 atggctacaa agaaagacca ggacgccgta aataattgtt tatcagtcta gaagcaagac
    19681 aaaaactcaa tttgagggaa agatccagta atttttctat gataaaaggc atcctatcaa
    19741 ggtttttgaa cacctgatag gatgcctttt tatgatattg aggccttttt gccctttttg
    19801 aaaaactaga atagaaacaa aatatataat agattgaaac tagaatagta cacatctgct
    19861 tctaaaacat tgttagaatt cgatttgact gtcctgatcg atttgtcctg ttcttatttc
    19921 attttaatat ataaaaaata t
//
LOCUS       DAVHSO010000041        19745 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.041, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000041 DAVHSO010000000
VERSION     DAVHSO010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19745)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19745)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19745
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.041"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            178..1659
                     /locus_tag="VVR18_001454"
     CDS             178..1659
                     /locus_tag="VVR18_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6032958.1"
                     /translation="MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKD
                     DLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQ
                     AESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSE
                     KYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFME
                     VDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESL
                     FMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEF
                     ILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHL
                     VINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSP
                     YDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE"
     gene            2021..3016
                     /locus_tag="VVR18_001455"
     CDS             2021..3016
                     /locus_tag="VVR18_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU6032959.1"
                     /translation="MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLRKVQR
                     AIKTLDYIPDNYARGMKKNRTETIALIIPSIWHPFFSEFAYHVEKELLKYNYKLFICN
                     ADSDSQNEIEYIEMLKQNKVDGIIGITYSDIDKYILSDLPFVSIDRHFSENVCYVTSA
                     NYKGGQTAAEELVRRDNKHLAFIGSINMYENETILRSKGFREKAKELGVDVYNFEMKE
                     PLINPEDQIRIFLQSHKEIDGIFTINDMMALRVISVMKELGKIAPDDYQIIGFDGLKT
                     SVDQSYLVSTIVQDIGMMAKESVAMILKMIKREEILEKRIVIPTYFWGDKTTKKI"
     gene            3143..4453
                     /locus_tag="VVR18_001456"
     CDS             3143..4453
                     /locus_tag="VVR18_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HEU6032960.1"
                     /translation="MRKGTMLSVVAGLSLAILAGCSGGTNSKQASSSNDIKVWVQFSD
                     ETNEGKAWQKVVDNFNQSGKSKYKVVTEYIPRSGSGGGYEDKVNAAITTNSLPDVITL
                     DGPNTAAYAKSKVITPLDDYLKDNNMDDVLDSIKQQGTYNGKFYAFGFSESNVGVYYN
                     KKMFKEAGIAESELPTLEKPWTWDEFNTIAKKLKDHYNKPAIDFRINSNDEMLPYAYM
                     PLIWSNNGSVVNEDGTKAEGYFNSKESVEAVQFIQNLVKEGYTTVSPVEKGFETGEYP
                     MLLSGSWTIADMNTNYKDIDFGILPYPVSSKTKKLVSPSGSWQLAVTTKSDKKEAASE
                     FVKFATNTESSEIISLGNSVLPIRKSTIENIKDKVSEPMRFLMEQNSKTAHARPVVVA
                     YPQVSRAFQQAMQDISYYEENPNVQKVLDTRTKEMQTAIDQSLK"
     gene            4549..5451
                     /locus_tag="VVR18_001457"
     CDS             4549..5451
                     /locus_tag="VVR18_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6032961.1"
                     /translation="MSKETVVYTKRREKIKDNILGYSFLAPALILLGIFLVIPVGMVI
                     YYTFTDYYLLTPDERKFVGFENFIRLTKDPIFLKSFLNTLKFVVWIIPVQLGAALGMA
                     LIVNKKRKGNMFFKVAFFAPVVMSLVVISILWLYLLNPNSGLLNAILNKVGIASQPFL
                     TSPKQAMYAIVFVSAWQGAGYQMLLFLGGMQNIPQDVYEAAELDGFSKWAQFRYITMP
                     LLKPTALFVLLTTLISAFKLIVQPMVMTQGGPLNSTITMVYYIYQQGFTDRLVGYSSS
                     IALVFTTLIGMISLVQRRVLKEDD"
     gene            5453..6298
                     /locus_tag="VVR18_001458"
     CDS             5453..6298
                     /locus_tag="VVR18_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU6032962.1"
                     /translation="MKRFKPTTILEYILLTLLAGLFLFPMVWMVVSAMKPEADVYKNL
                     TSWQAFLPSLNPADWFKPYQEVFERFSIFTYLGNSIFYAGTFAIGSIIVNALAGFAFA
                     KVNFSGKKILFGFLLALLIIPVETVLIPQFTIINSLGLVNNRFAVIIPGLASVFNIYL
                     FRNFFIAIPEEILESAKMDGASIVRIFFRIMLPMSKPAVATVGVLSFISSWNDYIWPL
                     MVLTDSSKFSMQVAITTINTTQPVYINQVMAVLTISTIPLILVYVVAQKYIVQGLGGS
                     GTGIK"
     gene            6308..7627
                     /locus_tag="VVR18_001459"
     CDS             6308..7627
                     /locus_tag="VVR18_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEU6032963.1"
                     /translation="MINKTFTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNG
                     FVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSG
                     SAIVKDDRLWLMYTGHIEEKTGVRQVQNMAFSDDGIHFEKISQNPVATGSDLPDELIA
                     ADFRDPKLFEKDGRYYSVVAAKHKNNVGCIVLLGSDNLVEWQFESIFLKGVEHQGFMW
                     ECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWGEKRFIPESVQEIDH
                     GQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQ
                     FPVKKGQYQIQIDKDCHYHLGNDTDYLEFGYDSNVQQVYIDRSHLIQKILGEEEQDTS
                     RRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID"
     gene            complement(7837..7909)
                     /locus_tag="VVR18_001460"
     tRNA            complement(7837..7909)
                     /locus_tag="VVR18_001460"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(7874..7876),aa:Lys,seq:ctt)
     gene            complement(8174..9445)
                     /locus_tag="VVR18_001461"
     CDS             complement(8174..9445)
                     /locus_tag="VVR18_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001113185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HEU6032964.1"
                     /translation="MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMIL
                     YGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHR
                     LDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQ
                     IALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDKGIRHITL
                     DIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYTARLIEAGDLPSLAR
                     RLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYV
                     AMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKI
                     RNHHYFQAEDTGKYERALAQRKEAIDRLRKI"
     gene            9715..9954
                     /locus_tag="VVR18_001462"
     CDS             9715..9954
                     /locus_tag="VVR18_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000818079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032965.1"
                     /translation="MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFRE
                     DTPKEILDLYENIKSKLDFAYQEVHSNNGLKKYEK"
     gene            10119..10298
                     /locus_tag="VVR18_001463"
     CDS             10119..10298
                     /locus_tag="VVR18_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032966.1"
                     /translation="MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDY
                     TDDELLDKEAVFTTH"
     gene            10435..10614
                     /locus_tag="VVR18_001464"
     CDS             10435..10614
                     /locus_tag="VVR18_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicA family
                     toxin"
                     /protein_id="HEU6032967.1"
                     /translation="MPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGE
                     LNKYTERGIRKQAGL"
     gene            10651..11103
                     /locus_tag="VVR18_001465"
     CDS             10651..11103
                     /locus_tag="VVR18_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000961815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="HEU6032968.1"
                     /translation="MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAM
                     GSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSV
                     DVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA"
     gene            11394..11864
                     /locus_tag="VVR18_001466"
     CDS             11394..11864
                     /locus_tag="VVR18_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3013 family protein"
                     /protein_id="HEU6032969.1"
                     /translation="MATYGFLDVLEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNA
                     AGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYF
                     ALFLKDTAEVGLDVLMDFLEDPEAEEFIMEWNQEVFEEGKEGLEEGEFYPYPRY"
     gene            11883..12950
                     /locus_tag="VVR18_001467"
     CDS             11883..12950
                     /locus_tag="VVR18_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HEU6032970.1"
                     /translation="MKKIGTYLVYVLAVVFIMLAFACGTIAFAELGYSAVLAFTFGYA
                     FALLSMYLIFILHELGHAFCGYLTGYRLVAFGLGHFILTKKSGRFHLSRTAILKNVGA
                     QYIGLKEDESDQRIILMLSGGLMVHLGLILLAIVFGFLTRSWYFAGTWIFLNLSFFLN
                     NILPVDITDGAKIWELLQHPENTKYAYLVLRHSAQTLLAPQEYDLKDFVQAVPEDARG
                     SFADGVLGMQGEVSILEGKEEVAKQQFQALLERTTTPMMQTVAQLSLLHIALLEGDFE
                     QAEQYASIRQVKSFLSLKLSNLQVIQAWYQFKVRKDVVQTHKAMKIARQKMDSSRMLR
                     DEKRYYENLLAELEKELAEGV"
     gene            12952..13380
                     /locus_tag="VVR18_001468"
     CDS             12952..13380
                     /locus_tag="VVR18_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU6032971.1"
                     /translation="MEIEISGFTGCKIALFCGDKLLTILRDDKDDIPCPNMWELPGGG
                     REGDESPFECAAREVYEELGIHLTEDCLLWSKVYPSMLFADKQSVFLVGQLTQNQFDS
                     IVFGDEGQGYQLMNVEEFFSSSQVVPQLQERLKDYLKVSD"
     gene            13518..14468
                     /locus_tag="VVR18_001469"
     CDS             13518..14468
                     /locus_tag="VVR18_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000451122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HEU6032972.1"
                     /translation="METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYMGNVD
                     RFGEIFPEVEQQEEIVVTAYYPDTVDVTVVEADLQARISELTDFMDLGELKIGTTALA
                     EEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMS
                     LFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNPG
                     MENIHVAAGDLLKGVEIEADVIVANILADILIHLTEDAYRLVKDEGYLIMSGIIKDKW
                     DMVRELAESAGFFLETHMVQGEWNTCVFKKTKDISGVIGG"
     gene            14470..15213
                     /locus_tag="VVR18_001470"
     CDS             14470..15213
                     /locus_tag="VVR18_001470"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001188214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HEU6032973.1"
                     /translation="MQQYFVKGSAISPVTIEDKETSKHMFQVMRLKEEDEVTLVFDDG
                     IKRLARVLDMENRQFELVQELNDNVELPVQVTIASGFPKGDKLEFIAQKVTELGASQI
                     WAFPADWSVAKWDGKKLGKKVEKLEKIALGAAEQSKRNIVPSIHLFENKADFLAQLDQ
                     FDRILVAYEEAAKEGEAAALIKAVTGLEKGAKLLFIFGPEGGLSPAEIENFEAKGAVL
                     AGLGPRILRAETAPLYALSALSVLLELEK"
     gene            15224..17020
                     /gene="pepF"
                     /locus_tag="VVR18_001471"
     CDS             15224..17020
                     /gene="pepF"
                     /locus_tag="VVR18_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEU6032974.1"
                     /translation="MEQKHRSEFPEKELWDLTALYQDREDFLRAIEKAREDINQFSRD
                     YKGNLHTFEDFEKAFAELEQIYIQMSHIGNYGFMPQTTDYSNDEFANIAQAGMEFETD
                     ASVALTFFDDALVAADEEVLDRLGKLPHLTAAIRQAKIKKAHYLGADVEKTLTNLGEV
                     FYSPQDIYTKMRAGDFEMADFEAHGKTYKNSFVTYENFYQNHEDAEVREKSFRSFSEG
                     LRKHQNTAAAAYLAQVKSEKLLADMKGYDSVFDYLLAEQEVDRVMFDRQIDLIMKDFA
                     PVAQRYLKHVAKVNGLEKMTFADWKLDLDSALNPEVTIDDAYDLVMKSVEPLGQEYCQ
                     EVARYQEERWVDFAANSGKDSGGYAADPYRVHPYVLMSWTGRLSDVYTLIHEIGHSGQ
                     FIFSDNHQSYFNAHMSTYYVEAPSTFNELLLSDYLENQSNDPRQKRFALAHRLTDTYF
                     HNFITHLLEAAFQRKVYTLIEEGETFGASKLNSIMKEVLTDFWGDAIEIDDDAALTWM
                     RQAHYYMGLYSYTYSAGLVISTAGYLHLKNSETGAEDWLNLLKSGGSKTPLESAMIIG
                     ADISTDKPLRDTIQFLSDTVDQIIAYSAELGE"
     gene            17267..18058
                     /locus_tag="VVR18_001472"
     CDS             17267..18058
                     /locus_tag="VVR18_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2785 domain-containing protein"
                     /protein_id="HEU6032975.1"
                     /translation="MYQDLLRKIAEEKPNYNQEEIQWLLDHLGDPSPEIRDDLVFTSF
                     ARGIQEELFTQEQFHFIAEGVSSDGGLDKEIDKIGLPTLERSFRALIYATLLSDDANQ
                     QSIFYQRLKAEIRNVLLNQGLHYLSKEEDTTGFSSQYGWVHSFAHGADLLTEVVCHPD
                     FPKNRVHEVFDILGQLFKRMSIRFTDDEDWRLARVIYEPILQGKLAQEQVASWIKTVD
                     FPIEEREDFYKFSNFRTCLLEVYVQLDQRNSLQDDLKEAIQSFQY"
     gene            18169..18837
                     /locus_tag="VVR18_001473"
     CDS             18169..18837
                     /locus_tag="VVR18_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin"
                     /protein_id="HEU6032976.1"
                     /translation="MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAI
                     VVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLGN
                     SGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
                     LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFL
                     GTEE"
     gene            complement(19091..19624)
                     /gene="queF"
                     /locus_tag="VVR18_001474"
     CDS             complement(19091..19624)
                     /gene="queF"
                     /locus_tag="VVR18_001474"
                     /EC_number="1.7.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent 7-cyano-7-deazaguanine reductase
                     QueF"
                     /protein_id="HEU6032977.1"
                     /translation="MKRQSALVVFSGGQDSTTCLFWAMQHYETVEAVTFAYGQRHHLE
                     IQITREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFSY
                     RNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNYGKQGTKYEGLA
                     EQRLFQHDLYPEKIDNR"
BASE COUNT         6043 a         3331 c         4298 g         6073 t
ORIGIN      
        1 tgtattcacg ccctcaatag acggtaaaat aagaaaattg tttatatatt gtctccgtag
       61 tgttattata cgaaataaaa gattttagga aaagtcgtta tatcatgcta tacctattct
      121 ttgtggtata attgcaagag gtttaatccg ataatttata aagagagaaa gatattcatg
      181 agagatttat tatctaaaaa aagtcatagg caattagaat tattagaatt attatttgaa
      241 cataaacgtt ggtttcatcg ttctgaacta gcagagttat taaattgtac agaacgtgca
      301 gtcaaagatg atctatccca tgttaaatct gcttttcctg acttgatttt tcattcttct
      361 actaatggta tacgcattat taataccgat gatagtgata ttgaaatggt ttaccatcat
      421 ttctttaaac attcaactca tttttcgatt ttagaattca tcttctttaa tgaaggttgt
      481 caagctgaga gtatttgtaa agaattttat atcagttcat cttcgctcta tcgtattatt
      541 agccaaatca ataaagtgat taaaaggcaa tttcaatttg aagtcagtct gacccctgtt
      601 caaatcattg gaaatgagag agacattcgt tacttttttg cacaatattt ttcagaaaaa
      661 tattatttcc tagaatggcc atttgaaaat ttttcatcag agccactatc tcaattgtta
      721 gaattggttt ataaggaaac aagctttcca atgaatttgt caacgcatag aatgctaaag
      781 ttgctcctag ttacgaacct atatagaata aagtttggtc attttatgga agtagataaa
      841 gattctttta acgaccaaag tttggatttt ttaatgcagg cagaaggaat agaaggtgtt
      901 gctcagagtt ttgaatcaga atacaatatc tctttagatg aagaagttgt ttgccaatta
      961 tttgtgtctt actttcaaaa aatgtttttc atagatgaaa gtctctttat gaaatgcgta
     1021 aaaaaggata gttatgttga aaaatcttac catctattga gtgattttat tgatcagatt
     1081 tcagtcaagt atcagattga aatggagaat aaggataatc tgatttggca tctgcataat
     1141 accgcacatc tgtatcgtca agagttgttt actgagttta ttttatttga tcaaaaaggg
     1201 aatacaatca ggaactttca aaatattttt ccaaaatttg tttcagatat aaaaaaagag
     1261 ctttctcact atttagagac tcttgaggtt tgttctagtt caatgatggt aaatcatcta
     1321 tcttatacct tcatcactca taccaaacat ttggtgatta atttgctaca aaatcagcct
     1381 aaactaaagg ttttagttat gagtaatttt gatcagtatc atgcaaaatt cgttgcagag
     1441 acactttctt attactgtag caataatttt gaactggagg tttggaccga attagaatta
     1501 tcaaaggaat ctttagaaga ttcaccttat gatatcatta tttccaattt tattattcct
     1561 cctattgaaa ataagagact catctattca aataatataa acacggtctc actcatatac
     1621 ttgttaaatg ccatgatgtt tattcgatta gatgagtaac caaaaataac aaaaaaacgc
     1681 tatttcgcgt ttgaactgta cctcaaaagt tagacagaaa aagtctaatt tttagggtgt
     1741 ttttgttaag aaaagacctt caatcattta agaaaaatgt acatctagat ttatagccct
     1801 ctaaaactct tgcttttttt gtagaagata cgaaaaaagc catgaaacca aggcttttcc
     1861 tgttttatgt agatgtttac acatgaaaat tgaagtattt tcaaaagcta attggagtga
     1921 ttttattcat gatgggataa atgatctggc caaaaatgat tgagaaatag ttgcttaaaa
     1981 agcatttgca tgatactata tattgaaagg agttgataat atggtagaac aaagaaaatc
     2041 aattaccatg aaagatgttg ctttagaagc aggagttagt gttggaactg tttcacgtgt
     2101 aattaataaa gaaaaaggca ttaaagaagt aactttaagg aaagttcaaa gggctataaa
     2161 aacattggac tatatccctg ataattatgc tcgaggtatg aaaaagaata gaacagaaac
     2221 tatcgctttg attattccga gcatatggca tccatttttt tcggagtttg cctatcatgt
     2281 tgagaaagag ttattaaaat ataattataa attatttatt tgtaacgctg atagcgattc
     2341 acaaaatgaa atcgaatata tcgaaatgtt gaaacaaaat aaagtggatg gaattattgg
     2401 tattacatat tctgatattg acaaatatat tttatctgat ttaccgtttg taagtataga
     2461 tagacatttt tcggaaaatg tatgctatgt tacttcagca aattacaaag gaggacaaac
     2521 tgcagcagag gaactggtta gaagggataa taagcacctt gcttttattg gttcaattaa
     2581 tatgtatgag aatgagacta tactcagaag taaaggattc agagaaaaag ctaaggaatt
     2641 aggagtagat gtctataatt ttgaaatgaa agaaccttta ataaatcctg aagatcagat
     2701 aagaattttt ttgcaatctc ataaagaaat tgatggtata tttacaataa atgatatgat
     2761 ggctctgaga gttattagtg ttatgaaaga actggggaaa atagcacctg atgattacca
     2821 gataattggg tttgatggtt taaaaacttc tgtcgatcaa tcttatctag tgtctacaat
     2881 agttcaagat attggtatga tggcaaaaga atctgttgca atgatactga aaatgattaa
     2941 gcgagaagag attctagaaa aacgaatcgt aattcccaca tatttttggg gagataaaac
     3001 aacaaaaaaa atttaaaaag cgcttgacaa ttaatgaaag cgctgttata atataatcaa
     3061 caaatgaaac gtttcaaaaa taggctagaa gcttgtttaa aaaataaata aaaaatgaaa
     3121 cgtttcaaaa aggaggaaaa tgatgcgtaa aggtacaatg ttatctgttg ttgcggggct
     3181 atcgttagct atacttgcag gttgtagtgg aggaactaac tcaaaacaag cgagttcttc
     3241 aaatgatatt aaagtctggg tacaattctc tgacgaaaca aatgaaggaa aagcttggca
     3301 aaaagttgtt gataacttta atcaatcagg aaaaagtaag tacaaggttg taactgagta
     3361 tattcctcgt agtggtagtg gtggaggata tgaagacaag gttaatgctg ctattacgac
     3421 taatagtctt ccagatgtta ttacccttga tggaccaaat acggcagctt atgcaaaatc
     3481 taaagtaatt actccgctag atgattatct aaaagataat aatatggatg atgttttgga
     3541 cagtattaaa caacagggaa cttataatgg gaaattctat gcatttggat tttctgaatc
     3601 gaatgttggt gtttattaca ataaaaaaat gttcaaagag gccggaattg cggaatcaga
     3661 gcttccaacg ctagaaaagc catggacatg ggacgaattt aatacgattg ctaaaaaatt
     3721 gaaagatcat tataacaaac cagcaattga ttttcgtatt aattcaaacg atgaaatgtt
     3781 gccatatgct tatatgccgt tgatttggtc aaataatggt tctgtcgtaa acgaagatgg
     3841 aacaaaggca gaaggatact tcaactccaa agagagtgta gaagcagttc aattcattca
     3901 aaatcttgta aaagaaggct atacaactgt tagtccagtc gaaaaaggtt ttgaaacagg
     3961 agagtatcca atgcttttga gtggttcttg gacgattgct gacatgaata caaactacaa
     4021 agatattgat tttggtatcc ttccttaccc agtatctagt aagacgaaaa aattagtatc
     4081 cccttcaggt agttggcaat tagctgtgac gacaaaatct gataaaaaag aggccgcatc
     4141 tgaatttgtt aaatttgcta caaatacaga atcaagtgaa attattagct tggggaattc
     4201 ggtccttcca attcgtaaat ctacaattga aaatatcaaa gataaagtat ccgaaccaat
     4261 gcgtttcttg atggaacaaa attcaaaaac agctcatgct cgcccagttg ttgtagcata
     4321 tcctcaggtt tctcgagctt ttcaacaagc aatgcaagat attagctatt atgaagaaaa
     4381 tccaaatgtg caaaaagtct tggatactcg tacaaaagaa atgcaaactg ctattgatca
     4441 gtcactcaaa taatctgtaa aaaagaaggt ggaaggaaaa tgtttggaac taccttcccc
     4501 tttcttgtta atagcctagt ttgatatata tgattaaagg agatggatat gagtaaagaa
     4561 actgttgtgt atacaaaaag acgtgaaaaa ataaaggata acatattagg ttatagtttt
     4621 ttagctccag ctttaatttt attaggtatc tttttagtaa ttccagttgg aatggtcatt
     4681 tattacactt ttacagatta ttatttgttg acaccagatg aaagaaaatt tgttggattt
     4741 gagaatttta ttcgattaac aaaagatccg attttcttaa agagcttctt gaatactttg
     4801 aaatttgttg tttggattat tccagttcaa ttgggagcgg ccttaggaat ggctttgatt
     4861 gtcaataaaa agcgaaaagg aaatatgttt tttaaagtgg ctttttttgc tccagttgtc
     4921 atgtccttgg tagttatttc tattctttgg ctttatcttt taaatccaaa tagtggctta
     4981 ttaaatgcta ttttaaataa ggtaggtatt gcttctcaac ctttcttgac tagtcctaaa
     5041 caagctatgt atgcaattgt ttttgtttct gcttggcagg gtgcaggtta tcagatgctt
     5101 ttatttttag gaggaatgca gaatattcca caagatgtct atgaagctgc tgaattagat
     5161 ggattctcaa aatgggctca gtttcgttat atcacgatgc ccctactaaa accaacagcc
     5221 ctgtttgtat tgttaacaac tttaatttct gcttttaagc tgattgtaca accaatggtt
     5281 atgacgcaag gtgggccatt aaactcaaca attactatgg tgtactatat ttatcaacaa
     5341 ggttttactg atcgtcttgt aggatattct agctcaatcg ctttagtatt tacaacgtta
     5401 attggtatga ttagcttagt acaacgtcgc gttctgaagg aggatgacta agatgaaacg
     5461 atttaaacca acaacaatct tagaatatat tctgttaact ttattggcag gactcttcct
     5521 ttttcctatg gtttggatgg tagtttcagc tatgaagcca gaagcggatg tttataaaaa
     5581 tttgactagt tggcaagcct tcttaccaag tttaaatccc gctgattggt ttaaacctta
     5641 tcaggaagta tttgagcgct ttagtatttt tacatatcta gggaacagca ttttttatgc
     5701 tggaacgttt gctattggtt ctattattgt caatgcactg gccggtttcg cttttgcaaa
     5761 agtcaatttt tcaggtaaga aaattttatt tggtttctta cttgctttac ttattattcc
     5821 agtggaaact gtgttaattc cacaatttac cattatcaat tccttaggtt tggtcaataa
     5881 tcgttttgca gttattattc caggattggc gagtgtattt aatatttact tatttaggaa
     5941 tttctttatt gcaattccag aagagattct tgagtctgca aagatggacg gagcaagtat
     6001 cgttagaatt ttctttagaa ttatgcttcc aatgtctaaa cctgcagttg ctacagttgg
     6061 tgttttatca tttatttcaa gctggaatga ttatatctgg ccattgatgg ttttgacaga
     6121 ttcttctaaa ttttcaatgc aggttgcaat tacaactatt aatacaactc aaccagttta
     6181 tatcaatcag gtaatggctg tattaactat ttcaacgatt ccgttgattt tggtctatgt
     6241 agtcgctcag aaatatattg ttcaaggtct gggtggttcc ggaactggaa taaaatagga
     6301 tatacttatg ataaataaaa catttacagt agaaaaagcc aatcgtttta tagcagaaaa
     6361 taaacatctc gttaatactc aatataagcc tgaagaacat ttttcagctg agattggttg
     6421 gatcaatgat ccaaatggat ttgtctattt tcgtggagaa taccatctct tttatcaatt
     6481 ctatccatat gatagtgttt gggggcctat gcactgggga catgctaaaa gtaaggactt
     6541 ggtgacttgg gagcatttgc cagtggcact tgctcctgac caagattatg accgaaatgg
     6601 ttgtttctca ggctctgcca ttgtcaagga tgatcgcctc tggctcatgt acactgggca
     6661 tatcgaagaa aaaaccggtg tccgccaagt gcaaaatatg gcattttcag atgacgggat
     6721 tcactttgaa aagatttccc aaaatccagt tgcaactgga tcagacttgc cagatgagtt
     6781 gattgctgct gatttccgtg atccaaaact ctttgaaaaa gatggacgct attactccgt
     6841 agtagctgcc aaacacaaga ataatgtggg ctgtatcgtt ctactagggt ccgataacct
     6901 agtagaatgg cagttcgaat ccatcttttt aaaaggggta gaacaccaag gctttatgtg
     6961 ggaatgccca gattacttcg agttagatgg gaaagattgc cttattatgt cacccatgcg
     7021 ttatcagcgt gagggagact catatcataa catcaactca tcgcttttgt tcacgggtaa
     7081 ggtagattgg ggagaaaaac gttttatccc agaatcagtt caagaaattg atcatggcca
     7141 agacttctat gcgcctcaaa cattgttgga cgatcaaaat cgtcgtatcc tgattgcttg
     7201 gatgcagaca tgggggcgta cccttccaac ccatgaccaa gaacacaagt gggcatgtgc
     7261 catgacttta cctagaattc taagattgga agatggcaaa ctaagacaat tccctgttaa
     7321 aaaaggccaa tatcaaatcc aaatagataa agattgtcat taccacttag gaaatgatac
     7381 agattatctt gaatttggtt atgacagtaa tgtgcagcaa gtttacattg atcgtagcca
     7441 tcttattcaa aaaattctag gtgaagaaga acaggacact agtcgacggt atgtagatat
     7501 tgaagctaaa gaattggaag ttgttctaga taaaaattcc atcgagattt ttgtcaatca
     7561 aggtgaagca agcttgactg caacttatta cttaacggtg ccagctgagc tatcacgaat
     7621 tgattaaaaa ttaagttatt tctcctaaag aaaaagttct ctttctaaaa tagtggaaag
     7681 aggacttttt gtgttttggg tatataagct tagtttatgg tatttgtaaa attggtgttg
     7741 gattatgatt taaactagtt ttctaaagaa tttgaaaaaa attttattta agcaaaaaaa
     7801 gccctatatt ataagacttt tcctgttgta tttagatgcc ccctacaggg atcgaacctg
     7861 tgacccacgg attaagagtc cgctgctctg ccagctgagc taaggaggca aagaaaaaag
     7921 ctgtattggt gccgaaactt cacggtttgt attgaacccg cgcaattaag caggtgggca
     7981 actcgctcta actgaagctg tttccgtgtg agacggccta catgctgtta gaagactttt
     8041 gtttccctaa taatacaaaa aatagtcggt caacacttaa gtgtgaagtc gtacaccaca
     8101 gcgtttctat atttatatga taccactttt tcaaaaaaaa tcaagaggaa agtgcaattt
     8161 tttgaaaagg atttcagatt tttcgcaaac ggtcgatagc ttcctttctt tgagccaaag
     8221 cccgttcata tttaccagta tcttctgctt ggaaatagtg atgattacga attttttctg
     8281 gcagatagtc ttgcttgacc caatttccag gatagttgtg tggatagaga tagtcttggg
     8341 cattccccag ttccttgctt ccactgtagt gcccatcacg taggtgtcgc ggaataggca
     8401 agtgccctga tgttttgagg tcagcaagtg ccttatccat agctacatag gctgagttgg
     8461 attttggaga aagggccaaa tcaatcacga cattggcaat gagaatgcgg gcttctggga
     8521 acccaatctt ctgggcggca tccagagcag tcacggtatg aatctgggcc tcaggattgg
     8581 ctaagccgat atcttcatag gcgataacag tcaagcgacg agcgagacta ggcagatccc
     8641 cagcctcaat caagcgggca gtatagtgga gactggcatc cacatctgag ccacggatag
     8701 acttttgcag ggcagataga acatcatagt gaccgtctcc atccttgtcc atagtgatgt
     8761 agcttctctg aagactattt tccatgatgt ctaaggtgat gtggcgaatg cccttgtcat
     8821 tctcaggggt agagagaaca gccaagtcca gtgagttaaa ggcagagcga aggtctccgt
     8881 ttgtagaggt tgcgatgaaa tccagcgcat cctcatctag ttctattgga aaatcaaaac
     8941 cacgttcagg gttacttaga gctatctgca gggcctcttt gacgtcttgg ttagacagag
     9001 gttccaactc gaaaatttga acacggctac gaatggcagg agtgacagag aagaaaggat
     9061 tttcagtcgt tgctccaatc atgatgacca gtccactttc caagagaggc aagaggaagt
     9121 cttgcttggt cttatctagt cgatgaattt cgtctagcaa taggacgaga ccaccagaaa
     9181 atttagcttc ttccgagatt tcttgcagtc gctttttact atcaactgtc gcattgaaag
     9241 ttcgaaaggc atacttggtc gttccagcga tggcagaggc aatactggtt ttgccgattc
     9301 ccggagggcc atatagaatc atggaggaca ggcggttggc ttccaccatg cggcggatga
     9361 tttttccagg tccgaccaga tgctcctgac cgatgacctg gtcgatggtt ttagggcgca
     9421 tgcgaagcgc gagattgtct ggcatagcag tcctttctaa cgtggatttg agtagaatga
     9481 ctcatctact atatcttact atgtccattc tagcctatta gttgtgatat ttcaatggtt
     9541 ttgtaataat cagggagtga gatagaatct tttttactat ttaatttaat gaggagaggt
     9601 atcagcatga gagatttgat tttccttaaa gctcaaaata ggatagttga gcctaaagaa
     9661 gtggaagtgc tgacttgaga aataatattg ctaaatgtca ttgtatgaac tataatgaaa
     9721 agagaggtga taagcaatgg aaatgatgga ccaagtcagg aaattttgat ttttacaaaa
     9781 caaattcgtc attggattct tagtgatcaa gttatttcag ggaaaagaaa acttttcttc
     9841 cgggaagata ctccaaaaga gattttagat ttgtacgaaa acattaaatc taaacttgat
     9901 tttgcttacc aagaagttca ttctaataat gggttgaaaa aatatgaaaa atagaataat
     9961 tgatgttttt gaagtagtaa atcgcctcct tgtaataact gttgaaaatc ctgatttcga
    10021 agacttgaga gttaatcata ctcaatgaaa atcaaagagc aaactaggaa actagccgca
    10081 ggctgtactt gagtacggta aggcgacgtt gacgtggttt gaatttgatt ttcgaagagt
    10141 atcagtttgt aaaaattgga gataaaaaat atagagtacg cagtgttcct atgattcatt
    10201 caactccgcc tcaatctgtc ttagatcgag atacttttac aattgactat acagatgatg
    10261 aattgctcga taaagaagca gtttttacta ctcattagaa aaataggtct gaataaattg
    10321 gtttccctta gaaccacatc taggggcttt tatgtataat agaataataa gtatcactcc
    10381 tttacaatac gtgtaacacg tgttataatg gtgttgtcag gaggtaaaag cgctatacct
    10441 atgacacaaa aagagatggt taaactcctt acggcccatg gttggataaa gactagaggc
    10501 ggtaaaggct cccatattaa aatcgagaag caaggggaaa gacctatcac aatccttcat
    10561 ggtgagctga ataagtacac tgaaagaggg ataagaaagc aagctgggtt gtaaaattca
    10621 gcccctgctt tttgatatgg aggtagtgaa atgttagtta cgtatccagc tttattttat
    10681 tatgatgaca cagacggaac agaagcgact tattttgtcc atttcccaga ttttgaatac
    10741 tcagctacac aaggagaggg gatttctgag gctttggcta tggggtcgga gtggctaggg
    10801 ataactgttg cagatttgat agagagtgat ggagagttac ctcagccatc agatatcaat
    10861 agcttgtctt taattgataa tgatcctttt aaagatgatg aagatttcgt gtcaacctat
    10921 gaccttgata aatcttttat ttctatggta tctgttgatg tatcagaata cctaggaagt
    10981 caggaaccca ttaaaaagac tttgaccata ccaaaatggg cagataagtt gggacgagaa
    11041 atgggactta acttttctca gactttgaca gacgctattg cagataagaa agttcaagcc
    11101 taagattaag cgtggtatcg tggtaatagt caataaaaaa gcacgtccac ttgtgctagt
    11161 tactcgccta ttgattttat agatttatta gccctttcga gggcttttta tattgatttt
    11221 tatgagaaat gaagaaatca gacttttaag aaaatcactg ataccaaggg tttaaatgag
    11281 gtaatatggt ataattagga cataaaataa ttttgtggta agatggtagt atctatttta
    11341 gcatatttcc gagcaatcgg ggcgattaaa gagtcgcata gaaagaggac aaaatggcaa
    11401 catacggatt tttagatgtt ttagaggaag agttggacaa gaactttccc tttgactttg
    11461 agattagctg ggacaaacgc aaccatgcgg tagaagtgag ttttctattg gaagcgcaaa
    11521 atgctgcagg tgtggagatg gtggatgaag acggagaggt ttcatcagat gacattcttt
    11581 ttgaggaagc ggtccttttc tacaatcctg ccaagtcaac agtcaatgag gaagactatt
    11641 tgactgttat tccttacctg cctaaaaaag gattttcccg tgaattttta gcttattttg
    11701 cgcttttcct taaagatact gctgaggttg ggctagatgt cctcatggac tttttggaag
    11761 acccagaagc agaggaattt atcatggaat ggaaccaaga agtctttgaa gaaggaaaag
    11821 agggcttgga agagggagaa ttttaccctt atccaagata ctaggagttg gttggcggtg
    11881 ttatgaagaa aattgggact tatttggttt atgtgctagc tgttgtcttt attatgctag
    11941 cttttgcttg tggaacaatc gcatttgcag agttggggta ttccgcagtt ttagccttta
    12001 cttttggtta tgccttcgct cttctaagca tgtatttaat ctttattctt catgagctgg
    12061 gtcatgcttt ttgtggctac ttgacaggct atcggctggt ggcttttgga ttaggacatt
    12121 ttattttgac caaaaagtca ggcaggtttc atcttagtag aacagccatt ctgaaaaatg
    12181 ttggtgctca atacattggt ttaaaagagg atgaaagcga tcaaagaatc atcctgatgc
    12241 tttcaggagg cttgatggtt catctcggct tgatattatt ggcgatagtg tttggatttt
    12301 tgacaagaag ctggtatttt gcagggactt ggatttttct taatttatct ttcttcctaa
    12361 ataacatttt gccagtcgac atcaccgatg gagcaaaaat ttgggaatta ctacaacacc
    12421 ctgaaaatac caaatacgcc tacctggtat tgagacattc tgctcaaact ttgctggctc
    12481 ctcaagaata tgatttgaaa gactttgttc aagcagttcc tgaggatgca cgagggagtt
    12541 ttgcggatgg tgtattaggt atgcaaggtg aagtttccat tttggaaggg aaggaagaag
    12601 tagctaaaca gcagtttcaa gcattacttg agaggacaac tactccgatg atgcagacag
    12661 ttgcccaact atccctactt catatcgcct tgttggaagg agattttgag caagcggagc
    12721 aatatgctag tattcgacag gtcaaatcgt ttctgtctct caaactgtcc aatcttcaag
    12781 tgatacaagc ttggtatcaa tttaaggtaa ggaaagatgt ggttcaaact cacaaggcta
    12841 tgaagattgc tagacagaaa atggatagta gtcgaatgtt gagggacgag aaacgctatt
    12901 atgaaaactt gttagcagag ctggaaaagg aattagccga aggagtctaa tatggaaata
    12961 gagatttctg gtttcacagg ttgcaagatt gccctctttt gtggggataa gctactgacg
    13021 attttgcgtg atgacaagga cgatatccct tgtcccaaca tgtgggagtt gccaggtggt
    13081 ggacgtgaag gtgatgaaag tccttttgag tgcgcggcgc gtgaagttta tgaagaactg
    13141 ggcattcatc tgactgaaga ttgtctgctt tggagtaagg tttatccaag tatgcttttt
    13201 gcggataaac aatctgtatt tctagttggt cagttgacac agaaccagtt tgacagtatc
    13261 gtatttggag atgaaggaca gggctatcag ctgatgaatg ttgaggaatt ttttagttcc
    13321 agtcaagttg tccctcagtt gcaagagaga ttaaaagatt atttaaaagt aagtgattag
    13381 aaaggatggt tcagttaaat ttctaaactg aacccgccct aaacactgtg ccaaaaagat
    13441 aaacttctct tagacacaag cgtcttcaga gaatttccta ttttggtttt gtattttacg
    13501 ggcttggtat cttaataatg gaaacatggc aagagttaaa agttacagtg aagcgtgagg
    13561 gagaggagtt ggtttccaat ctcttgattg agctgggagc gcaaggagtc gcgattgaag
    13621 acagcatgga ctatatggga aatgtggatc gttttggcga gattttccca gaggtggagc
    13681 agcaagaaga aatcgtagtg acagcctact accctgacac ggtggatgtg acagtggttg
    13741 aggcggactt gcaggctcgc atatcagaat tgacggattt tatggatttg ggagagttaa
    13801 aaataggtac gactgccttg gctgaggaag actgggcaga taactggaag aaatactatg
    13861 agccagctcg tatcactcat gatttgacca tcgttccctc ttggacagac tatgaggcga
    13921 ctgcgggaga aaaaattatc aagctggatc ctggcatggc ttttggtacg ggaacccacc
    13981 caactaccaa gatgagcctc tttgccttgg aacaggttct tcgtggtggc gaaacggtgc
    14041 tagatgtggg aactggttca ggggttctct ctattgccag ctcgcttctg ggggctaaag
    14101 aaattttcgc ctatgacctg gatgatgtgg cagttcgtgt ggctcaggaa aatattgagc
    14161 tcaaccctgg aatggaaaat atccatgtag cggcaggcga tttgcttaaa ggcgtggaga
    14221 ttgaagcaga tgtcatcgtg gcaaacatct tggcggatat cctcattcat ctgacagagg
    14281 atgcttatcg cttggttaag gatgaaggtt acctgatcat gagtggcatt atcaaggata
    14341 agtgggacat ggtgcgcgag ttggctgaat cagctggatt tttcctcgaa actcacatgg
    14401 ttcaagggga atggaatacc tgtgtcttta agaaaaccaa ggatatctct ggtgtgattg
    14461 gaggctagca tgcagcagta ttttgtaaaa ggcagtgcta tctctcctgt cactatcgag
    14521 gacaaggaaa ccagtaagca tatgtttcag gttatgcgct tgaaagaaga ggatgaggtt
    14581 accttagtct ttgatgatgg catcaagcgc ttggcgcgcg tgctggatat ggaaaatcgt
    14641 cagtttgagt tggtccaaga attaaatgac aatgtggaac taccagtcca agtgaccatc
    14701 gcatctggat ttcccaaggg agacaagctg gagttcatcg ctcaaaaagt aaccgaactg
    14761 ggtgctagcc aaatctgggc ctttcctgca gactggtcag ttgccaagtg ggatggcaag
    14821 aaattgggta aaaaagttga aaaactagaa aaaattgccc ttggagcagc cgagcaaagc
    14881 aagcgtaata ttgttccaag tatccatctt ttcgagaata aagcagactt tctagcccaa
    14941 cttgaccagt ttgaccgcat cttagtagcc tatgaagagg cggccaaaga aggagaagcc
    15001 gctgctctta taaaagcagt tactggactc gagaaaggag ccaaattgct ctttatcttt
    15061 ggtccagaag gtggtctgtc acctgcggaa attgaaaatt ttgaagctaa gggagctgtt
    15121 ttggcaggac ttggccctcg cattctaaga gcagaaacag caccgcttta cgctttatca
    15181 gcccttagtg ttttattaga attagagaaa taagaggaag aaaatggaac aaaaacaccg
    15241 ttcagaattt ccagagaagg aactttggga tttaacagct ctataccaag accgtgagga
    15301 tttcttgcgt gcaatcgaga aagctcgcga agacatcaac cagtttagcc gtgattacaa
    15361 gggcaatctt cacacttttg aggatttcga gaaggccttt gcggaattgg aacagatcta
    15421 cattcagatg agccatattg gcaactatgg ttttatgcct cagacgacgg actatagcaa
    15481 tgacgaattt gcaaatattg ctcaagctgg gatggaattt gaaacagatg ccagcgtagc
    15541 cttgaccttc tttgacgatg ccttggtggc agcagacgag gaagtcttgg accgtttggg
    15601 taaattgcca catttaacag ctgccattcg tcaggctaaa atcaaaaaag cccactactt
    15661 aggggcagat gtggagaaga ccttgaccaa tctcggtgaa gttttctata gtccgcagga
    15721 catttatact aagatgcgag ctggggattt tgaaatggct gactttgaag cccatggcaa
    15781 gacctataaa aacagctttg tgacctatga gaatttctac caaaaccatg aggatgctga
    15841 ggttcgtgag aaatccttcc gttccttctc agagggactt cgtaagcacc aaaatacggc
    15901 tgcagcagcc tatctggctc aggtcaagtc tgaaaaactc ttggctgata tgaagggata
    15961 cgactctgtc tttgactatc ttctagctga acaagaagtg gaccgtgtca tgtttgaccg
    16021 ccagattgac ctcatcatga aggactttgc accagtcgct cagagatacc tcaagcatgt
    16081 tgccaaggta aatggtcttg aaaagatgac ctttgcagac tggaaattgg acttggacag
    16141 cgccctgaat cctgaagtga ctattgacga tgcctatgat ttggtcatga agtcggtaga
    16201 acctttgggg caagaatatt gtcaggaagt tgctcgttac caagaagagc gctgggtgga
    16261 ctttgctgct aacagtggca aggattccgg tggttatgcg gcggacccat atcgcgtaca
    16321 cccttatgta ctcatgagct ggacaggccg tttgagcgat gtctatacct tgattcatga
    16381 aatcgggcat tctggtcaat tcatcttttc agacaatcat caaagctatt tcaacgccca
    16441 catgtcgacc tattatgttg aagcaccgtc aaccttcaat gaattgctac tcagtgatta
    16501 cttagagaac cagtctaatg acccacgtca aaaacgcttc gctctggctc atcgcttgac
    16561 agacacctac ttccataatt tcatcaccca cctcttggaa gccgccttcc agcgtaaggt
    16621 gtatacattg attgaagaag gagaaacctt cggagcaagc aaactcaaca gtattatgaa
    16681 ggaagttttg acagattttt ggggcgatgc cattgaaatc gacgacgatg cagctttgac
    16741 ttggatgcgc caagctcact actatatggg cttgtatagt tacacttact cagcaggact
    16801 agttatctcg actgctggtt accttcatct taaaaattca gaaactggag ctgaagactg
    16861 gctcaatctc ctcaaatcag gtggtagcaa gacaccactt gagtcagcca tgattatcgg
    16921 tgctgatatt tcaacagaca aaccactccg tgataccatc caattcttgt ctgacacagt
    16981 tgaccagatt atcgcctaca gtgctgagtt gggggagtaa ggggaataga aaaatttttt
    17041 agaatgatgt ttatgggctt gttaagcgtc attctatttg tcttagttgt agctattttc
    17101 aaaaatgtcg ttgaaggtcg tgatgttaaa tttgaactta ctgtagaact ggtattgata
    17161 gttatttacg tcattttata tcagattgta tttaattgag aattcaatat tgagtcattt
    17221 aagactgcct ttttgaacag ttgctagaaa tgtagaggta ttgaccatgt atcaagattt
    17281 actaagaaaa atagcagaag aaaaaccaaa ttataaccag gaggaaatcc agtggttgct
    17341 tgatcatttg ggagatcctt ctccagaaat tcgcgatgac cttgttttta caagctttgc
    17401 tagagggatt caggaagagc tatttacaca ggagcaattt catttcattg ctgaaggggt
    17461 ttcatctgat ggagggttag ataaagagat tgataagata ggcctgccaa cacttgaacg
    17521 ttcttttagg gcgcttattt atgcaactct cttgtctgac gatgccaacc agcaatcgat
    17581 tttctatcag agactaaaag cagaaattcg taatgtcctt ttaaatcaag gcttgcacta
    17641 tctttcaaaa gaagaggata caacaggttt ctcaagtcag tatggttggg ttcattcttt
    17701 tgcacatgga gccgatttac tgacagaggt ggtttgtcat ccagactttc ctaaaaacag
    17761 agttcatgaa gtatttgata tacttggcca actatttaaa agaatgtcga ttcgctttac
    17821 agatgatgag gattggcgtt tagcaagagt gatctatgaa cctattttac aagggaagtt
    17881 agcgcaagaa caagtagctt cttggataaa aactgttgat tttccgatag aagaaaggga
    17941 ggatttttac aaattttcca acttcagaac ctgtctgttg gaagtctatg tccaacttga
    18001 ccagagaaat agtttacaag atgacctgaa agaagctatc cagtcttttc aatactaggg
    18061 ataagttaat agttctatga ttttcaaaaa atttccaatc aattttcttg aaaccctttc
    18121 ctacttttga tagactagta tctagttttt gaaaaaagga gaaagaaaat gaaaaaattt
    18181 gttgctgagt taatcggtac gttcatgctt gtattcgtcg ggacaggagc tgttgttttt
    18241 ggaaatggtc ttgatggcct tggtcacctt ggaatcgcct ttgcctttgg tttggcaatc
    18301 gtggtggcag cctactcaat cggaactgtt tcaggtgctc acttgaatcc ggctgtttcg
    18361 attgctatgt ttgtaaacaa acgtttgtca tcttcagaac ttgtaaacta catccttggt
    18421 caggttgttg gagctttcat cgcttctggc gcagtcttct tcctcttggg taattcaggt
    18481 atgtcaactg ctagtcttgg tgaaaatgcc ttggcaaacg gagtcactgt ctttggtggt
    18541 ttcttgtttg aagtcatcgc aactttcttg tttgtcttag ttatcatgac tgtgacttca
    18601 gaaagtaagg gcaatggcgc gattgctggt ttggtaatcg gtttgtcatt gatggcgatg
    18661 attcttgtcg gattgaagat tactggactt tcagtaaacc cagctcgtag cttggcacca
    18721 gctgtcttgg taggcggcgc agcccttcaa caagtttgga ttttcatcct tgcaccaatc
    18781 gctggtggag ttcttgcagc ccttgttgca aaaaatttcc ttggaacaga agaataattg
    18841 aaactcaaaa agccttgctc ctcatcttga ggaacagggc tttttcgtat gatactcttc
    18901 gaaaatctct tcaaaccacg tcagcttcac cttgtcctag gtatggttac tgacttcgtt
    18961 agttctatct gcaacctcaa aacagtgttt taagctgact tcgtcagttc tatctgccac
    19021 ctcaaacact gctttgagta acctgcggct aacttcctag tttgctcttt gattttcatt
    19081 gagtatgact ttagcggttg tcaattttct ctggataaag gtcgtgttgg aagaggcgtt
    19141 gttctgccaa gccctcatac ttagttcctt gcttaccgta gttatagtag gggtcgattg
    19201 aaatgccacc gcgcggagtg aattttcccc agacttctaa atagcgaggg tctagcaagt
    19261 tgaccaagtc tttcccgatg gtgttgatac agttttcgtg gaaatctccg tgatttcggt
    19321 agctaaatag atatagtttg agggattttg actcgacaca gagcttgtca ggaatgtagg
    19381 aaatatgaat cgtcgcaaag tctggctgag cagtgatttg tcccagcaga gacatatcga
    19441 ggatatggtg acgaatgccc tgttccttag cgatttctct agtaatttga atttcgaggt
    19501 gatgacgttg gccgtaggca aaggtgacag cttcgactgt ttcatagtgt tgcatggccc
    19561 agaaaaggca ggttgttgaa tcttgaccac cactaaagac gaccaaggct gattgacgtt
    19621 tcatagtact ccttccaaaa tgggaaatgt tcagagcacg caaaaagctc ccattaggga
    19681 gctaaaaaat accaaatcga gtttttttag cgatggcata tcccaaacat cgtaatattc
    19741 tactt
//
LOCUS       DAVHSO010000042        19640 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.042, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000042 DAVHSO010000000
VERSION     DAVHSO010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19640)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19640)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19640
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.042"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            144..2036
                     /gene="pepO"
                     /locus_tag="VVR18_001475"
     CDS             144..2036
                     /gene="pepO"
                     /locus_tag="VVR18_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase PepO"
                     /protein_id="HEU6032978.1"
                     /translation="MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLML
                     ATTDKWLAGEEVPEDAILENFVKYHHLVRDFDKREADGITPVLPLLKEFQELETFADF
                     TAKLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELL
                     TLWKESSANLLKAYDFSDEEIEDLLEKRLELDRRVAAVVLSNEESSEYAKLYHPYSYE
                     DFKKFAPALPLDDFFKAVIGQLPDKVIVDEERFWQAAEQFYSEEAWSLLKATLILSVV
                     NLSTSYLTEDIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSP
                     EAKADVEKKVATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKD
                     KVVNETASLFENALAFARVEIKHSWSKWNQPVDYKEWGMPAHMVNAYYNPQKNLIVFP
                     AAILQAPFYDLHQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLKDWWTESDYAA
                     FKEKTQKVIDQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFSAEEFFY
                     NFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDGMWRSPE
                     ERVIIW"
     gene            complement(2158..2787)
                     /locus_tag="VVR18_001476"
     CDS             complement(2158..2787)
                     /locus_tag="VVR18_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEU6032979.1"
                     /translation="MKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIEKIN
                     KPICAILLTHAHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMA
                     DVVTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETI
                     GRTDLPTGSMEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF"
     gene            3781..6003
                     /locus_tag="VVR18_001477"
     CDS             3781..6003
                     /locus_tag="VVR18_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019316080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HEU6032980.1"
                     /translation="MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYR
                     KSGEPYIIHPIQVSGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRVIV
                     DGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ
                     ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALV
                     DEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQS
                     DVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEV
                     AEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAE
                     EIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVE
                     IIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVA
                     NKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAE
                     AEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGR
                     GVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQ
                     VLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG
                     "
     gene            6033..6476
                     /locus_tag="VVR18_001478"
     CDS             6033..6476
                     /locus_tag="VVR18_001478"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HEU6032981.1"
                     /translation="MKIIIQRVKKAQVSIEGQIQGKINQGLLLLVGVGPEDQEEDLDY
                     AVRKLVNMRIFSDAEGKMNLSVKDIEGEILSISQFTLFADTKKGNRPAFTGAAKPDMA
                     SDFYDAFNQKLAQEVPVQTGIFGADMQVELVNNGPVTIILDTKKR"
     gene            complement(6947..7360)
                     /locus_tag="VVR18_001479"
     CDS             complement(6947..7360)
                     /locus_tag="VVR18_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032982.1"
                     /translation="MKKLYRIHFIAIAVIDLLLFAFFITRLETSFEWLLLSGLIFFLD
                     QGLLLFLLVVRLKHQFAEIYPQINKKIRFYYLGVLTIDFLFFVLLAFISSQRFSSLMS
                     IITACHSTFYYMTADYLRENYPDFYDKHISLWECL"
     gene            complement(7491..8138)
                     /locus_tag="VVR18_001480"
     CDS             complement(7491..8138)
                     /locus_tag="VVR18_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide mononucleotide transporter"
                     /protein_id="HEU6032983.1"
                     /translation="MVVGIAIASGYLNSRLHKFVDWGLWTALVPFGLISVTNVGISML
                     STRFTGKLSKWGNYFGIVNTILSGAIDYILGNKAAIITYPVTFLIYTFAIKKWKASQE
                     GRPNQMSQKQVKLAAIIISIIAFLFAFVTNYIGYGGKMNLLAYVTTIAFALSLIANAL
                     NALKLTTQWGFWLIYNFVQLTKAGIQGNFANIGKYIFYILNAIGALFVWNDEEVR"
     gene            complement(8164..8355)
                     /locus_tag="VVR18_001481"
     CDS             complement(8164..8355)
                     /locus_tag="VVR18_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032984.1"
                     /translation="MSRKSTNFSSPLPTLKVLFSGFYFYHFILLSFGGRIFEKNGRIF
                     EKKKGSLTYEKITKNFCYI"
     gene            complement(8336..8986)
                     /locus_tag="VVR18_001482"
     CDS             complement(8336..8986)
                     /locus_tag="VVR18_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000188500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="HEU6032985.1"
                     /translation="MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKR
                     MKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLE
                     HTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
                     SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQMNMDIAKQLYVEKIN"
     gene            9098..9940
                     /locus_tag="VVR18_001483"
     CDS             9098..9940
                     /locus_tag="VVR18_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HEU6032986.1"
                     /translation="MTKIALLSDIHGNTTALEAVLADAQQLGVDEYWLLGDILMPGTG
                     RRRILDLLDQLPITARVLGNWEDSLWHGVRKELDSTRPSQRYLLRQCQYVLEEISLEE
                     IEVLHNQPLQIHRQFGDLTVGISHHLPDKNWGRELIHTGKQEEFDRLVTHPPCDIAVY
                     GHIHQQLLRYGTGGQLIVNPGSIGQPFFLDAQLRKDLRAQYMILEFDDKGLVDMDFRR
                     VDYDVAAELQLAKDLRLPYFEVYYESLVNGIHHTHHQEFLRELAQKEGCDRELDDWLK
                     SGND"
     gene            10016..10453
                     /locus_tag="VVR18_001484"
     CDS             10016..10453
                     /locus_tag="VVR18_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HEU6032987.1"
                     /translation="MQIPSRFTIATHMLIIIALEGKESKVTSDFLAASVGVNPVIIRK
                     ILSQLKKAELISVARGTGGTEIVKDLKDISLLDVYQAVECLGKTGQLFSFHDNPNPNC
                     PVGAHIHDVLDQKLERIQLTMEAELGQTSLEKVVADAESQMKD"
     gene            10522..10824
                     /locus_tag="VVR18_001485"
     CDS             10522..10824
                     /locus_tag="VVR18_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000281600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032988.1"
                     /translation="MYLVIGIVLAFIVSFWKYNRSLWNPVLFLLSLISSYFYLSYLFY
                     KNGYENVQLAFYVFAFVLLPFLLFLSGIFLIYNGVILLKREGRSKPNYLSMLFDFY"
     gene            complement(10915..11988)
                     /locus_tag="VVR18_001486"
     CDS             complement(10915..11988)
                     /locus_tag="VVR18_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2974 domain-containing protein"
                     /protein_id="HEU6032989.1"
                     /translation="MANIFDYLKDVAYDSYYDLPLNELDILTLIEITYLSFDNLVSTL
                     PQRLLDLAPQVPREPTMLTSKNRLQLLDELAQHKRFKNCKLSHFINDIDPELQKQFAA
                     MTYRVSLDTYLIVFRGTDDSIIGWKEDFHLTYMKEIPAQKHALRYLKNFFAHHPKQKV
                     ILAGHSKGGNLAIYAASQIEQSLQNQITAVYTFDAPGLHQELTQTAGYQRIMDRSKIF
                     IPQGSIIGMMLEIPAHQIIVQSTALGGIAQHDTFSWQIEDKLFGQLDKTNSDSQQVDT
                     TFKEWVATVPDEELQLYFDLFFGTILEAGISSINDLASLKALEYIHHLFVQAQSLTPE
                     ERETLGRLTQLLIDTRYQAWKNR"
     gene            12144..12821
                     /locus_tag="VVR18_001487"
     CDS             12144..12821
                     /locus_tag="VVR18_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6032990.1"
                     /translation="MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQS
                     EPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKP
                     FDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
                     RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGI
                     GYGLKHA"
     gene            12814..13788
                     /locus_tag="VVR18_001488"
     CDS             12814..13788
                     /locus_tag="VVR18_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEU6032991.1"
                     /translation="MLDWKQFFLAYLRSRSRLFIYLLSLAFLVLLFQFLFASLGIYFL
                     YFFFLCCFVTILFFTWDILVETQVYRQELLYGEREAKSPLEIALAEKLEAREMELYQQ
                     RSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNL
                     VLQYLRLESFHDDLLLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKW
                     LLVVIEQIISNSLKYTKEGGLEIYMDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGR
                     LTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVLE"
     gene            complement(13837..15780)
                     /gene="thrS"
                     /locus_tag="VVR18_001489"
     CDS             complement(13837..15780)
                     /gene="thrS"
                     /locus_tag="VVR18_001489"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HEU6032992.1"
                     /translation="MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKL
                     IDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGF
                     YYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIE
                     EHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIY
                     GTAWFDKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRE
                     LERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPM
                     NCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTP
                     EQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAA
                     LDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADG
                     EDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVA
                     KKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQ
                     TVSVDNFVQAILADIANKSRVEK"
     gene            complement(15838..16014)
                     /locus_tag="VVR18_001490"
     CDS             complement(15838..16014)
                     /locus_tag="VVR18_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
                     /protein_id="HEU6032993.1"
                     /translation="MTKQGRYYDETPYTLEQKLSENIWWLLELSQRLDIDILTEMENF
                     LSDKEKQLNVRTRK"
     gene            complement(16021..16161)
                     /locus_tag="VVR18_001491"
     CDS             complement(16021..16161)
                     /locus_tag="VVR18_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000422774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
                     /protein_id="HEU6032994.1"
                     /translation="MELQELVERSWAIRQAYHELEVKHHDFKWTVEEDLLALSNDIGN
                     FQ"
     gene            complement(16592..16792)
                     /locus_tag="VVR18_001492"
     CDS             complement(16592..16792)
                     /locus_tag="VVR18_001492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6032995.1"
                     /translation="MRRFYSHLPYYLVILFFYWPLYELFLLVVSDPLTLEELYINNLL
                     FFTPLVILIISLLYSYRFRFSL"
     gene            17031..17660
                     /locus_tag="VVR18_001493"
     CDS             17031..17660
                     /locus_tag="VVR18_001493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HEU6032996.1"
                     /translation="MKLAVIAANGQAGKAIVEEAVKRGHEVTAIVRSENKSQAESIIK
                     KDLFELTKDDLTGFDAVISAFGAYTPDTLPLHSKSIELFNQLLAGTQTRFLVVGGAGS
                     LYIDETKTTRLLDTSDFPEEFKSLAKDQADELDLLRTKNNLNWTFVSPAVDFIPDGEK
                     TGNYILAGEIFTTNEKGISQISYADYAIGLVDELEKGHHIKERISLLEK"
     gene            17801..18070
                     /gene="rpsO"
                     /locus_tag="VVR18_001494"
     CDS             17801..18070
                     /gene="rpsO"
                     /locus_tag="VVR18_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HEU6032997.1"
                     /translation="MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIK
                     QHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR"
     gene            18884..19498
                     /locus_tag="VVR18_001495"
     CDS             18884..19498
                     /locus_tag="VVR18_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000531723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="HEU6032998.1"
                     /translation="MGQTIISAIGVYISTSIDYLIILIILFAQLSQNKQKWHIYAGQY
                     LGTGLLVGASLVAAYVVNFVPEEWMVGLLGLIPIYLGIRFAIVGEDAEEEEEEIIERL
                     EQSKANQLFWTVTLLTIASGGDNLGIYIPYFASLDWSQTLVALLVFVIGIIIFCEISR
                     VLSSIPLIFETIEKYERIIVPLVFILLGLYIMYENGTIETFLIV"
BASE COUNT         5798 a         3636 c         4449 g         5757 t
ORIGIN      
        1 agtgtaaaga acttggaatt atgcgtttta tcatggaaag gttttttata atagctaaaa
       61 aataatagtt aaatggttat taattgcatt ccctagtgat ttttgttaag ataaatgcaa
      121 atacaaatga aagcgagaac aagatgacac gttatcaaga tgatttttat gatgctatca
      181 atggagaatg gcaacagaca gctgaaatcc cagcagataa gtctcaaaca ggaggttttg
      241 ttgatttaga ccaggaaatt gaagacctga tgctggcgac aacagacaag tggttagcag
      301 gtgaagaagt gcctgaggat gctatcttgg aaaactttgt caaataccac cacctagttc
      361 gtgattttga caagagagaa gctgacggta tcacacctgt cttaccactc cttaaagaat
      421 tccaagaatt ggagactttt gcggatttta cagctaaact agcagagttt gagcttgcag
      481 gaaaaccaaa cttccttcct tttggtgtat cgccagactt tatggatgct agaatcaatg
      541 ttctatgggc tagcgctcca agcacaatct tgccagatac gacctactat gcagaagaac
      601 atcctcagcg cgaagagctc ttgactcttt ggaaagaaag tagcgcaaat ctcctcaagg
      661 cttatgattt ctctgatgaa gaaattgaag acttgctaga aaaaagactt gaattggacc
      721 gccgagttgc ggcagtggtg ctctctaatg aagaaagttc agaatatgct aaactctatc
      781 atccatattc ttacgaagat ttcaagaaat tcgcgcctgc cctacctttg gatgacttct
      841 tcaaagcagt tattgggcaa ttaccagaca aggttattgt agacgaggaa cgtttctggc
      901 aagcagcaga gcaattttac agtgaggaag cctggtctct ccttaaagca accttgattt
      961 tgagtgttgt caatctttca accagctatt taacagagga tatccgtgtt ttgtctggtg
     1021 cctacagccg tgccctttct ggagttccag aggcaaaaga taaggtcaaa gcagcttatc
     1081 atctagcaca ggaacctttc aagcaagccc tggggctttg gtacgcccgt gagaagttct
     1141 ctccagaagc caaggcggat gtggagaaaa aagtggcaac catgattgat gtctataagg
     1201 agcgtctgct taagaatgac tggctcactc cagaaacctg taaacaggct atcgtgaagc
     1261 tcaatgtgat caaaccttat attggctatc cagaagaatt gcctgcacgt tacaaggata
     1321 aggtagtgaa tgaaactgcc agtctttttg agaatgctct agcctttgcg cgtgtggaaa
     1381 tcaagcacag ttggagtaag tggaaccagc ctgtagacta taaggaatgg ggcatgcctg
     1441 ctcatatggt caatgcctac tacaatcctc agaagaacct gattgtcttt ccagcggcca
     1501 ttttacaggc gcctttctat gacttgcatc agtcatcttc tgctaactac ggtggtattg
     1561 gggcagtgat tgcccatgaa atttcccacg cctttgatac taacggggct tcctttgacg
     1621 aaaatggtag cctcaaggat tggtggacag agagcgacta tgctgccttc aaggagaaaa
     1681 cacaaaaagt cattgaccaa tttgatggac aggattctta tggagcaacc attaacggta
     1741 aattgactgt atcagaaaac gtggctgact tgggaggaat cgcagcagcg cttgaagcag
     1801 ctaagagaga agcagacttc tcagcagaag agttcttcta caacttcggt cgcatctggc
     1861 gcatgaaagg tcgaccagaa tttatgaaac ttttggctag cgtcgatgtg cacgcaccag
     1921 ccaaactccg tgtcaatgtg caagtaccaa acttcgacga tttctttaca acctatgatg
     1981 tcaaagaagg agacggaatg tggcgttcac cagaggagcg cgtgattatt tggtaatgca
     2041 aaaaatctag ttatcagaaa aaggcatcca atcacgtgtg aaaaccttga taggatgcct
     2101 tttgtaatag aaagatttgc tggatagttt acttaaattt cgattgtcat catcttgcta
     2161 gaaaaaggga ttgaaggcct tttcgtgagc gatagtagta gctggaccat gtcctggata
     2221 gacatcgtag tttggtaggg tgaagagttg ggtctggata ctatgaagga gttgctccat
     2281 gctaccagtc ggaaggtcgg tccgtccgat agtttcgcgg aatagagcat ctcccgtcaa
     2341 gactaggtga gcatcaggaa agactaggga aacaccaccg atagagtgcc ctggggtcgg
     2401 tagaacctta aaacgaaatt cctctagttg gtattcttcg tgaaagacaa aggtgtgttc
     2461 tgcaggtttt gtgaccacat ctgccatatc atcgtggcga gggagaccgg agagattatc
     2521 gacaggagtg tagagccagc tggcttcgct ctctgcgata tagacaggag gattgccaaa
     2581 cgtctcgcga accaagtcca gactcatgat atggtcataa tgggcgtggg tcaagagaat
     2641 agcacagatc ggtttgttga tcttctcgat tgtctgacga atggcttccc aatgactacc
     2701 aggatcgacg acgatgaggt gcttttcgcc ttctagataa taggtatttt cataggcaac
     2761 aggattcacg gttttatgga ttttcatact agctccaatc tcaaagaatg tactaatact
     2821 cttcgaaaat ctcttcaaac cgcgtcaact ttatctgcaa cctcaaagca gtgctttgaa
     2881 cagcctgcgg ctagctttct agtttgctct ttgattttca ttgagtataa attaagtata
     2941 gcacagttag ggagaatagg taaggattta aaatgaactt aaaaaccagc atgactagat
     3001 gaagacaggc tggttatcaa tttatcaata ttggaaaggt gtcaattgcc cttcataggt
     3061 tgcataaact ccgtcattag cttgtttgat agacgtgatg tttagagtgc taccgtagtt
     3121 ggcttctcat ttgtcgctat attcactata agttatccta ctgggcaggt tctggtcgtt
     3181 agcatagtat tgaacgagtt ttttatagct ttgctggctg aataggaaca ggcagcaaac
     3241 tcctaacatt aggagagcaa agatagaaat agcagttttt ttcataggta ttctccttat
     3301 aaactaaagg atagaagaaa gtatcttgag gatttttata ctcttcaaaa atctcttcaa
     3361 accgcgtcaa cgtcgccttg ccgtatatat gtgactgact ttgtcagtct tatctacaac
     3421 ctcaaaacag tgttttgagc agcctgcggc tagctttcta gtttgctctt tgattttcat
     3481 tgagtattaa ttccaaaatc cagtcaaggt accagtgtat gtgatacgag ttccaccgtt
     3541 tatctttcgt atcttcaatg gaattgggga aatcagaaag tctttgggtt acaatatggt
     3601 ttccgttctt ctatctctcc ttctatcacc taagtttaaa atctaacttc gtagtatatt
     3661 atgggtcaat aattcagaat tatcaagcaa ttttgaatta tttttttctt attctgttcc
     3721 aatctagttt tcatattctt aaaaaagtga taaaatggta ggaagaattg gagagtagag
     3781 atgccgaaag aagtgaattt aacaggcgaa gaagttgtcg ctttaaccaa agaatattta
     3841 acggaagagg atgttcattt tgtccataag gccttggtct atgctgttga atgccacagt
     3901 ggtcaatatc gcaaatcagg cgagccttat atcattcacc ctatccaagt gtcaggtatt
     3961 ttagctaagc taaagctgga tgctgtaaca gtagcttgtg gattcttgca tgatgtggtg
     4021 gaagatacag atgcgacctt ggacgatttg gaaagagagt ttggtcctga tgtgcgggtg
     4081 attgttgacg gagttaccaa gcttggcaag gtcgagtaca aatcgatcga ggagcaatta
     4141 gcggaaaatc atcgcaagat gctcatggcc atgtctgagg acatccgcgt tattttggtc
     4201 aaactgtctg accgcttgca caatatgcgg accctgaaac atcttcgaaa agacaagcag
     4261 gagcgtattt ccaaagaaac catggaaatc tatgccccac ttgcccatcg tttggggatt
     4321 tccagtgtca aatgggaatt agaagacttg tctttccgtt atctcaatcc aacggagttt
     4381 tacaagatta cccatatgat gaaggaaaag cgcagggagc gtgaggcctt ggtggatgag
     4441 gtagtcacaa aattagagga gtatacgaca gaacgtcact tgaaagggaa gatttatggt
     4501 cgtcccaagc atatttactc aattttccgc aaaatgcagg acaagagaaa acggtttgag
     4561 gaaatctatg atctgattgc tattcgttgt attttagata cccaaagtga tgtttatgcc
     4621 atgcttggtt acgtgcatga attttggaaa ccgatgccag gtcgcttcaa agactatatt
     4681 gccaaccgca aggccaatgg ttatcagtct atccatacga ctgtttatgg accaaaaggg
     4741 ccgattgaat tccagattcg aaccaaggaa atgcacgagg tggctgagta cggggttgcg
     4801 gctcactggg cttataagaa aggtataaag gggcaagtta acagcaagga atcagctatt
     4861 ggaatgaact ggatcaagga gatgatggag ctccaagacc aggctgatga tgctaaggaa
     4921 tttgtggact ctgttaagga aaactatttg gctgaggaga tttacgtttt taccccagat
     4981 ggagctgtcc gttcccttcc caaagattca ggaccgattg attttgccta cgaaatccat
     5041 accaaggtcg gtgaaaaagc aactggtgcc aaggtcaatg gccgcatggt tccactgaca
     5101 accaagttaa agacagggga tcaggttgaa attatcgcca acccgaactc ctttggacct
     5161 agccgtgact ggctcaatat ggtcaagact agcaaggcgc gcaataagat tcgccagttc
     5221 tttaaaaacc aagataagga attgtctgtc aacaagggtc gtgagatgct gatggctcag
     5281 ttccaagaaa atggctatgt ggcaaataaa tttatggaca agcgccacat ggatcaagtt
     5341 ctgcaaaaga ccagttacaa gacagaagac tccctctttg cggccattgg ttttggggaa
     5401 atcggtgcga ttaccgtctt taaccgtctg actgaaaagg aacgccgtga ggaagagcgt
     5461 gccaaggcca aggctgaggc agaggagctt gtcaaaggtg gcgaggtcaa ggttgaaaat
     5521 aaagaaactc tcaaggtcaa gcatgagggg ggagtggtta ttgaaggtgc ttctggtctc
     5581 ctagtgcgga ttgctaagtg ttgtaacccc gtgcctggtg acgatattgt tggctacatt
     5641 accaagggtc gtggtgtggc tattcaccgt gtggactgta tgaacctgcg tgcccaagaa
     5701 aactacgagc aacgtctcct tgatgtggaa tgggaagacc agtactctag ctcaaataag
     5761 gagtatatgg cccatatcga tatctacggt ctcaaccgta caggactgtt gaacgatgta
     5821 ctgcaagttc tttcaaatac aaccaagaat atttcaacgg tcaatgccca accaaccaag
     5881 gatatgaagt ttgctaatat ccatgtgtcc ttcggtattg ccaacctctc tacactgacc
     5941 acggttgtcg ataaaattaa gagtgtgcca gaagtttact ctgtcaaacg gaccaacggc
     6001 tagttgtcct agctcttact agaaaggcta ttatgaaaat cattatccaa cgggttaaaa
     6061 aagcccaagt gagtatagaa ggccagattc agggaaaaat caatcaggga cttttattgc
     6121 tggttggtgt tggaccagag gaccaagagg aagatttgga ctatgctgtg agaaaactgg
     6181 tcaatatgcg gattttttca gacgcagaag gcaagatgaa cctgtctgtc aaagatattg
     6241 aaggagaaat cctctctatt tctcagttta ccctctttgc ggatactaag aaaggcaatc
     6301 gtccagcctt tacaggggca gctaaacctg atatggcatc agacttctat gatgctttca
     6361 atcaaaaatt agcgcaagaa gtgcccgttc agacaggtat ctttggagca gatatgcagg
     6421 ttgagctggt taataacgga cctgttacca ttatcctaga tactaaaaag agataagaaa
     6481 gaccaagccc agtcggcttg gtctttctca tcgatcataa aatactccaa aaagaaatcg
     6541 gttcttgata tgcttagggg aagtctcttt tcaggctttg gcagatgcga taggaaggga
     6601 tgagatgtcc taggatgagg agagttccct gaaggaaaag tggaatatca cttaaagaca
     6661 ccaaggagag aatcatcagg ctatcccata ggagaatttg taaagcaaaa cgccagaatc
     6721 tcggtctaat ctgggaatag agttaactaa agtggtcaca aagttggttt gaaagatagg
     6781 tcaatagcac aggatgaaag aaaatgagcc aaccgctata aatcaaaatc cagtcccaag
     6841 taagcccccc ttttaaatgt caaaaatgcc agcatgattc catcaatgac aaggagttga
     6901 atggttttga tgaagatgat tttttcatgc taaaacctcc ttttccttag agacactccc
     6961 ataaagagat gtgtttgtcg taaaagtctg gatagttttc tcttaggtag tcagctgtca
     7021 tataataaaa agtagaatgg caagcagtga taattgacat aagagatgaa aaacgctgag
     7081 aactaatgaa ggctaagaga acaaaaaata gaaaatcaat ggtgagaacc cctaaatagt
     7141 agaagcgaat ctttttattg atttgaggat aaatctcagc gaattgatgt ttgagtcgga
     7201 cgaccaagag aaatagcagg agtccttgat caaggaagaa aattaaacca gagagcaaga
     7261 gccactcaaa agatgtctcg agtctagtga taaaaaatgc aaatagtagc aaatcaataa
     7321 ctgcaattgc tataaaatgg attctataga gttttttcat gacaagacct tcctctttta
     7381 tctaacttca ttctactcca aaagaatggg agttacaact aaaatgataa aaatagcaga
     7441 ggggagattc tcttaagttg gctagtattc tttatttgag tttccttcta ttatctaact
     7501 tcttcatcat tccagacaaa taaagctccg attgcattga ggatataaaa gatgtattta
     7561 ccgatattgg cgaagtttcc ttgaatacca gcttttgtca gctgaacgaa attgtaaatc
     7621 aaccaaaagc cccactgagt tgttagtttc aatgcattca aagcattggc aatgagggac
     7681 agtgcaaagg caatagttgt tacgtaggca aggagattca tcttgccccc atatccgata
     7741 tagttggtca caaaggcaaa gaggaaggcg atgatggaaa tgatgatggc cgccaatttt
     7801 acctgttttt ggctcatttg gttgggtctg ccttcttgcg aagctttcca tttctttata
     7861 gcaaaggtat aaatgaggaa ggtgacggga taggtaatga tggccgcctt atttccaagg
     7921 atataatcaa tagcaccgga caaaatggta ttaacaatac caaagtaatt tccccatttg
     7981 cttaatttcc ccgtgaaacg agtggacaac atggaaatcc caacgttggt tacggaaatc
     8041 aatccaaagg gtacaagagc tgtccatagt ccccagtcta caaatttatg gaggcgtgag
     8101 ttgagataac cagatgcaat cgcaatccca acgaccaaag caaccccgaa gaggtcaaac
     8161 tatttagatg tagcaaaaat ttttagtgat tttttcatag gttaaactac ctttcttttt
     8221 ttcaaatatt ctcccatttt tttcaaatat tctcccacca aatgaaagta aaataaaatg
     8281 atagaaataa aaccctgaaa ataaaacttt cagggttggt aggggacttg agaaattagt
     8341 tgattttctc gacatagagt tgttttgcaa tgtccatatt catttgtaaa tcctcgtcgt
     8401 tactgaggat agtgaaggta ttgctgaagc catcaaactg cttgacttgg agctggtcac
     8461 cgatgtgaag tgagtgcttg tccagataat ggagaatgtc aaaactatcg tgcacccgag
     8521 tcaggcggta ggcgccagct tccttgatat cagctagtgg gaggttattg atttcaacga
     8581 ggagttctcc cttggcagga atagttcctc cgtgggggca ggttttaggg aaacctagca
     8641 gtttatctag tctttccacg aacaggtcag agacagtgtg ttccaagacc tcagcttcct
     8701 cgtgaatctg gtcacttgta tagtctaaat gatgaactag aaaaacttca atcaagcggt
     8761 gcttacgata gagctcagag accagtttga gaccgaggtc agtcagtaga tagccacatt
     8821 ccttgtcctt taggatgaga ttttcacttt tcattcgttt gatcatttca gttacggcag
     8881 ggggagagac ttgcatgcga gccgcaattt ccttgttggt aatcttatgc aggtctatgc
     8941 caatttcata aatacatttt agatagtctt ctttgtttgg ggtcattcgt ttcctcttgt
     9001 ctaatatctt tatctagtat atcaaaaaaa gctagatttc tctagctgtg actttttatg
     9061 ttatacttat tgcaagagaa aaaacgagga gatggatatg acgaaaatag ctcttctttc
     9121 agatattcat ggaaatacca ccgccttgga ggctgttttg gcagatgctc agcagctagg
     9181 agtggatgaa tactggcttt tgggagatat tctcatgcca gggacaggac gtagaaggat
     9241 tttggacttg ttggatcaac taccgattac ggctagagtt ttgggaaact gggaagacag
     9301 tctttggcat ggtgtccgta aggaattgga cagtactcgc cccagtcaac gctatctctt
     9361 gcgccagtgc cagtatgttt tagaggaaat ttccctagaa gaaattgaag tgctccacaa
     9421 tcaacctctt caaattcatc gtcagtttgg ggatttgacg gtgggaatta gccatcatct
     9481 gcctgataag aactgggggc gagagttgat tcatactggc aaacaagagg agtttgaccg
     9541 cttggtgact catcctccct gtgatattgc tgtttatgga catattcacc agcagttgct
     9601 tcgttacggg actggtgggc aattgattgt caatccgggt tcgattgggc aacctttctt
     9661 tttggacgct cagctacgga aggacttgcg ggcccagtat atgattttgg agtttgatga
     9721 caagggcctg gtagatatgg acttccgacg ggtagactac gatgtggcag ctgaattgca
     9781 gctggctaaa gacctgagac ttccctattt tgaggtttac tatgaaagtc tggtcaatgg
     9841 gatccaccat actcatcatc aggaattttt gagagaattg gctcagaaag agggctgcga
     9901 tcgggagtta gacgactggt tgaaaagtgg taacgattga cattacaact aaaaagggta
     9961 taataataga aaaagaagag tagaggcagg gtagcctcgt aaaaaggaga agaggatgca
    10021 aattccaagt agatttacca ttgcgactca tatgctgata atcattgccc tcgaggggaa
    10081 ggaaagcaag gtgaccagtg attttctggc tgctagtgtc ggggtcaatc ctgtcattat
    10141 cagaaagatc ttgtcccagt tgaagaaggc agagctgatt tcagtagcgc gtggaacggg
    10201 cggaacagag attgtcaagg accttaagga tattagtctt ttagatgttt atcaggcggt
    10261 cgaatgtctt ggtaagacag gtcaactctt cagtttccat gacaatccga atccaaattg
    10321 ccctgtagga gctcatattc atgatgtttt ggatcaaaaa ttggagagaa ttcagttgac
    10381 tatggaggca gaacttggtc aaaccagtct agaaaaagtc gtggccgatg cagagagtca
    10441 gatgaaggat taagagggat aaatgccctc tttttttctt tggataatta tgataaaatg
    10501 tagctattaa aggagtaaga aatgtatctc gttataggaa ttgtattagc ctttatagtg
    10561 tcattttgga agtataatag aagtttgtgg aatccagtat tatttttatt atccctcatt
    10621 tcaagttatt tttatctatc ctaccttttt tataaaaatg gatacgagaa tgttcagtta
    10681 gctttttatg tatttgcctt tgtcttactt ccttttttgc tttttctaag tggcatcttt
    10741 ttaatctata atggggtcat tttgttgaaa cgagagggac gttccaagcc caattatctt
    10801 tcaatgctat ttgattttta ttgactatta gattctattt aaaaagactt agaatgcaca
    10861 tgaaagtatg tattctaggt cttttgtttt gtatacattt aattttcaag agtattatct
    10921 atttttccat gcctggtaac gagtatcaat caataactgg gtaaggcgac ccaaggtttc
    10981 tctttcttct ggagtgaggg attgagcttg gacaaagaga tgatgaatgt attcaagcgc
    11041 ctttaaggaa gccaagtcat tgatagagct aataccagcc tcaagaatag tgccaaagaa
    11101 gaggtcgaag tagagctgaa gttcttcgtc agggactgtg gccacccatt ctttaaaggt
    11161 tgtgtctact tgctggctat cactgttggt cttatccagt tggccgaaga gcttgtcctc
    11221 aatctgccaa ctaaaggtat cgtgctgggc gatgccaccc agggcagtac tctgaacgat
    11281 gatttggtga gcaggaattt ccagcatcat accgataatg gaaccttgtg gaatgaatat
    11341 cttgcttcta tccattatcc tttgataacc cgcagtctgt gtcaattctt gatggagacc
    11401 aggtgcatca aatgtataaa ctgctgtgat ctgattttgc aaactttgct caatttggct
    11461 agcagcatag atagcgagat ttcctccctt ggaatgcccg gccagaataa ccttttgctt
    11521 aggatgatga gcaaaaaagt tctttaaata gcgaagggcg tgcttttgag caggaatttc
    11581 cttcatatag gtcaggtgga aatcttcctt ccagccaatg atactgtcat ctgtcccacg
    11641 aaagacaatc agataggtat cgaggctgac acgataagtc atagccgcaa attgcttttg
    11701 cagttcaggg tcgatgtcgt tgataaaatg ggagagtttg caatttttga agcgcttgtg
    11761 ttgagccaat tcatctaata attgaaggcg atttttgcta gtaagcatgg tgggctctct
    11821 tggaacctga ggtgctagat ctaaaagacg ttgaggaagt gtggagacca gattatcaaa
    11881 ggagaggtag gtgatttcta ttaaggttag aatgtctaac tcattcaagg gaaggtcgta
    11941 ataagaatca tatgcgacat ctttcagata gtcaaaaata ttggccataa gagctccttt
    12001 ctttttattt atcttagcaa atttccctca aattagctag tagcatagcc tgtttgtact
    12061 ggctaaaaac aggctatttc aaattcagtt tcagaccatc tagcatggaa aaatctgtta
    12121 taataataga aaaggagaag cgcatgcaca agattttatt aatagaagat gatcaggtca
    12181 ttcgtcaaca gattgggaaa atgctctctg aatggggatt tgaagtggtc ctggtagaag
    12241 actttatgga agttttgagt ctatttgttc agtcggaacc tcatctggtc ctcatggata
    12301 ttggtttgcc cttgtttaat ggttatcact ggtgtcagga aatccgcaag atttccaagg
    12361 tacctatcat gtttctttct tcgagagacc aggctatgga tattgtcatg gcaatcaata
    12421 tgggggcgga tgactttgtg accaagcctt ttgaccagca ggttctttta gctaaggttc
    12481 agggcttgtt gcgtcgttcc tatgagtttg ggcgtgatga gagtttgctg gaatatgctg
    12541 gtgttatcct caataccaaa tccatggatt tacattatca agggcaagtc ttgaatttga
    12601 ccaagaatga attccagatt ttacgcgtgt tatttgagca tgcaggcaac atcgtagcac
    12661 gtgacgacct gatgcgggaa ctttggaaca gtgacttttt cattgatgat aataccctct
    12721 ctgtcaatgt ggctcgtttg cgtaaaaagt tggaggagca gggattggta ggatttatcg
    12781 agaccaagaa aggaataggg tacggattga agcatgcttg attggaaaca attttttcta
    12841 gcctatctgc gctcccgtag tcgtcttttt atctatctgc tttctttggc atttcttgtc
    12901 ttactctttc agtttttatt tgccagtcta ggaatttact tcctctactt tttcttcttg
    12961 tgttgctttg taaccatatt atttttcact tgggacatat tggtggaaac gcaggtctat
    13021 cgccaggaac ttctctatgg agagagggaa gccaagtctc ctttggaaat agctttagca
    13081 gaaaaattag aagcgcgtga gatggaactc tatcagcaga ggtcaaaagc agaaagaaaa
    13141 ctgacggatt tgctggatta ctataccttg tgggtccatc agataaagac ccccattgca
    13201 gccagtcaac tcttagttgc agaagtggtc gaccgccaac tgaagcagca gctagaacag
    13261 gaaattttca aaatcgactc ctataccaac ctagttttac agtacctgcg tttagaaagt
    13321 ttccatgatg atttgctctt aaagcaggtt caaattgagg acttggtcaa ggaaataatt
    13381 cgtaaatatg ctcttttctt tattcaaaaa ggcttaaatg tcaatctaca tgaccttgat
    13441 aaagaaatcg tgacggataa aaagtggctg ctagtggtta ttgagcaaat catctcaaac
    13501 agtctcaagt acaccaagga aggtggtctg gagatttata tggatgacca agagctttgt
    13561 atcaaagata cgggaatcgg gataaaaaac agtgatgtcc tccgagtatt tgaacgtggc
    13621 ttttcaggat acaatggccg tttgacccag cagtcctctg gacttggcct ttatctatct
    13681 aagaaaattt ctgaagaact ggggcaccag attcgtatcg agtctgaggt cggaaaagga
    13741 acgacagtgc ggattcagtt tgctcaagtg aacttagtcc ttgagtaaaa atagatgaga
    13801 aaaagcctcc agattggagg cttttatgct agactcttat ttctcaacgc gtgatttgtt
    13861 ggcgatatca gctaggatag cttgaacaaa attatcaact gagacagttt gtgtttcttt
    13921 ttggccgtag cgacgaacgt tgactgtttc gtcttccatt tctttgtctc caacaattaa
    13981 ttggtaagga atcttgctgg tttgtgaagc acggatcttg aactgcattt tttcattgcg
    14041 ctcatctacg tctgcacgga caccgcggtc acggagtttc ttggccactt cccaagcgta
    14101 gtccacgtgt ttttcgttag atactgggat gagggttact tggtgtggtg ccagccatgt
    14161 tgggaaggcc cccttgtagt tctcaatcaa gatagctgtg aagcgttcca tagttgagat
    14221 aaccccacgg tggatcatga ctggacggtg atcttcgcca tcagctccga tgtatttgag
    14281 gtcgaagcgt tctggcaaca agaaatcaag ttggatagta gaaagggttt cttcttttcc
    14341 aagggcagtt ttaatctgga tatccaattt tggtccgtag aaggctgctt caccttcggc
    14401 ttcaaagtag tccacgccca tttcatcaag agctgcacga agcatggttt gggcattttc
    14461 ccacatctca tcgttatcaa agtacttatg agtatcttga gggtcacgaa gagagaggcg
    14521 gaagcggtag tcagtcaagt tgaagtcttc ataaacatcg ataatcaact gaagggcacg
    14581 ttggaattct tcttggattt gttctggagt aacgaatagg tgaccgtcgt tgagtgacat
    14641 ttcacgtaca cgttgaaggc cagtgagggc accagatttt tcgtaacggt gcatcatacc
    14701 gatttcagcg atacggattg gcaattcacg gtaagagtga acatggtgtt tgaaaacttg
    14761 gatgtggtgc ggacagttca ttggacgaag gacaaattct tccccgtcac ccatgtccat
    14821 ggttgggaac atgtcttctt ggtaatgatc ccagtgacca gaagtcttgt aaagctcaac
    14881 agaagcaagt ggtggagtgt agacgtgttg gtagccagaa gccaactctt tgtttacgat
    14941 gtagcgttcc aattcacgac ggatagtcgc accatttggt aaccagaatg gcaaaccttg
    15001 tcccacttct tgtgaaatca taaagaggtc aagctcttta ccaagtttac ggtggtcacg
    15061 ttccttagct tcttcacgca tttgaaggta gtttttcaag tctttcttgt caaaccaagc
    15121 tgtaccgtag atacgttgca tcatagcgtt gtcgctgttt ccacgccagt acgcaccagc
    15181 tacatggaga aggtggaaga tttggatacg acctgttgat ggaacatgag gtccacggca
    15241 gaggtctaca tattcaccct gacgatagat agtcaaaccg ccttcgtctt ctgagtgttc
    15301 ttcaatcaat tccaacttgt aagggtcatt tttgaagatt tcacgtgcct cgtctttagt
    15361 cacttcttca cgaatagatg ggaagttttc tttgacgatt ttttgcattt cttcttcgat
    15421 acgaggaagg tcttcgttag agatttgacc agctgtgttg tcagtatcgt agtagaaacc
    15481 atcttcgatg gctggaccaa ctcccaagtg aatgtctggg aaaagacgac gagctgcttg
    15541 ggcgaacaag tgagctgctg agtgacgcaa gattggaagg gcatcttcgt gatcaggtgt
    15601 cacaatttcg atgcttccat cttcagtgat agcgcgagta gtgtcgatga gtttgccgtt
    15661 gaatttacca gccaaggctt ttttagctag ggaattgctg atagattggg caatttcaaa
    15721 agttgttacg ccagattcga attcacgaac agcgccatct gggaaagtaa tgttaatcat
    15781 gatgttctcc ttttttatta tttcatagtt tctaagcatt gattttttat cagcagacta
    15841 cttccgagtc ctaacgttca attgcttttc tttatcagag aggaagtttt ccatttccgt
    15901 cagaatgtct atatccaaac gttgagaaag ttctaatagc caccagatat tttctgaaag
    15961 tttttgttcc agtgtgtagg gtgtttcatc atagtagcgt ccttgctttg tcatcaccag
    16021 tcattggaaa tttccaatat cattagataa agccaagagg tcttcttcta ccgtccactt
    16081 gaaatcatga tgcttaactt ccagttcgtg ataagcttgt cggattgccc aactgcgctc
    16141 cactaattct tgcaactcca taattagtat cctaataaaa aaatgcgaca tcctcgaaag
    16201 gacgtcgcaa cgtggttcca ccttcattta tgtacctcaa aagagaggga cacctctgat
    16261 cggctctaac gtggccaccg ttttatgttt tcataaaaaa ctcaagagta gtatcagttt
    16321 agacttccta tgcgtttcca gcaaccacgc actctctagt agaaagggac taagtgactt
    16381 gtctctatgg attattatag catgattgtg agatttttca aggattttgt gaaagttttt
    16441 tgtttttcat tttttgtaga atatgcttga tgctaatacc agaatccatg ccgaccagag
    16501 caactgtttc atagattagc aagtaaatta gtataaactc accaaaggtt atgatagtaa
    16561 agtaaaagag cagtccgtta ccaactaacc atcaaagtga gaaacggaaa cggtagctat
    16621 agagtaacga tataatcaag attaccagag gtgtaaagaa gagaagattg tttatataga
    16681 gttcctcgag tgtaaggggg tcagaaacaa ctagtaagaa caactcataa agtggccaat
    16741 aaaagaataa tatgaccaga tagtagggga gatgggaata gaatctacgc atgataatca
    16801 cctcgtttta aaaaaacaga caacttagat ctcttgctat gattattata gcatgtttaa
    16861 aacaagaaag taaatttgtt gacaaagaag atttttcttt tcactagaat catagttagt
    16921 tttcttggta gaaatatttt gataataatt aagcaagact attgacattg attattaaga
    16981 gtgtcacaat tattgtaact aaaataatta caacaagaga ggtataaaaa atgaaactag
    17041 cagttattgc agcaaatgga caagcgggga aagcaattgt tgaagaagca gtcaaacgag
    17101 gacatgaagt aacggctatt gttcgttctg aaaacaaaag tcaagctgag tctattatta
    17161 aaaaagattt atttgagttg acaaaagatg atcttactgg atttgatgct gttatttcag
    17221 cgtttggtgc ttatacacca gatacgctac cgctccacag caaatcaatc gaactattta
    17281 atcagcttct tgctggaaca cagacacgtt ttctagttgt agggggagca ggaagtcttt
    17341 atatagatga aacaaaaacg acacgacttt tagatacgtc tgattttcct gaagaattta
    17401 agtcactagc aaaagatcaa gcggatgaat tggatcttct tcgtacaaaa aataatctca
    17461 actggacttt tgtcagtcct gctgtagatt ttattcccga tggtgaaaaa acaggaaact
    17521 acattctagc aggagaaatt tttactacta atgaaaaagg aataagccag attagttatg
    17581 cagattatgc tattggattg gtagatgaac ttgaaaaagg tcatcatata aaagaacgta
    17641 tctctttact tgaaaaataa taactatgag agtattaatg tttgacagaa aatttaaatc
    17701 ttggtaaaat aggggttgtc gtaaagacaa ataacttctt cttggttaca ggcatgccaa
    17761 cctgtcactc ggatgaagcc aaataaaaag gagaaacatc atggcaatct caaaagagaa
    17821 aaaaaatgaa atcattgcac aatatgcacg tcacgaaggt gatacaggtt cagtagaggt
    17881 tcaagttgct gtccttactt gggaaatcaa ccaccttaac gaacacatca aacaacacaa
    17941 aaaagaccac gctacttacc gtggattgat gaaaaaaatc ggtcgccgtc gtaacttgct
    18001 tgcatacttg cgtaaaaacg acgttaaccg ttaccgtgag ttgatcaact ctctaggact
    18061 tcgtcgctaa ttcaagatac aaatgctgtc aaaagcacaa agcaaaaata ggaaaattga
    18121 cgaagaaact tcagtttcta ggagatttta tcttttttgc caagtgctta ggccgtgttc
    18181 aattgagcat atcttgataa taaagctact ctaaattggg tagctttttt gcgttgtcac
    18241 cttacctcgc tatactcaag tataatcttc ggttacggtt cctagcactg taaggtaaaa
    18301 taaaccagct tttctccctt cggggagatt tttttgtttc actgaaagtt tcgtacgatc
    18361 ttcgcctcgt cgcctagtct ataaacgatt tatctagcaa gaatcatgat gctaagggcg
    18421 tcaaaaatcc gtatgaaaat agggaaatga cacagtgttc gatgagcaca aggagtttca
    18481 tctttttcac taggatttta gcccgggcta aaatcagctc tctgacttca gagggctttt
    18541 ttattgaggt tttatcggta acaattttgg agactacaaa aacctcaaat ggtatcagct
    18601 aattacacca taaaggtgcg cagttactcg gcttttcaag ccgagtagct gtatgcaagc
    18661 cccctagaag agcccactct ttacaaagta aagtatagta tgttatactt tacatggaag
    18721 tagtcactga attccagtta gaaattactt tgtaactacg ttttgaggag gagtaaaatg
    18781 ctttcctacg ttcgacatta cccactagcg atagctaaat taatgtgtct gtgctctcct
    18841 gaaatctgct gatttattac tgactaatac aggaggtttt tttatgggac agacaatcat
    18901 atctgctatt ggtgtttata tttccaccag tatcgattat ttaattattt taattatttt
    18961 atttgcacag ctatcacaga ataaacagaa atggcatatt tatgcggggc aatatctagg
    19021 cacaggctta cttgtagggg cgagtttagt tgctgcttat gtcgttaatt tcgtgcctga
    19081 agaatggatg gttggattgc ttggtttaat ccctatctat ttagggattc gctttgcaat
    19141 tgttggagaa gatgcggaag aagaagagga agaaattatt gaaagattag aacaaagcaa
    19201 ggcaaatcaa ctgttttgga cagttacatt gctgacaatt gcgtctggcg gagataattt
    19261 aggtatctat ataccttatt ttgcttcgtt agattggtca cagaccctcg tggccttgct
    19321 tgtgtttgta atcggcataa ttatcttttg cgagattagt cgggtgttat cctctattcc
    19381 gttaatattc gagacaattg aaaaatacga gcgaatcatt gtgcccttag tattcattct
    19441 acttggacta tacatcatgt atgaaaatgg cacgatagag acttttctga tcgtgtagat
    19501 ttttttgttt cactaggatt ttagccctct gaaaatcagc tctctgattt tcagagggct
    19561 ttttcattga gcataaatgg acaatcttaa agttactcta ttgtagagtg gcttttgatt
    19621 tgattaggag attcttataa
//
LOCUS       DAVHSO010000043        19135 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.043, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000043 DAVHSO010000000
VERSION     DAVHSO010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19135)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19135)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19135
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.043"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(112..387)
                     /locus_tag="VVR18_001496"
     CDS             complement(112..387)
                     /locus_tag="VVR18_001496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HEU6032999.1"
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQ
                     LIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK"
     gene            complement(494..1333)
                     /locus_tag="VVR18_001497"
     CDS             complement(494..1333)
                     /locus_tag="VVR18_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEU6033000.1"
                     /translation="MTKIKIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLK
                     EEGKFLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGHILAIHMSHALSGTVEAARQ
                     GASLSTADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILSHVEEVKNHTELYIGV
                     STLENLVKGGRISRVTGLLSSLLNIRAVMQMKDHELQPMVKGRGTKTFKKWLDELITS
                     LSERAVAEIGISYSGSDDWAKEMKESLQAYVEKPISVLETGSIIQTHTGENAWAILIR
                     YHS"
     gene            1475..2323
                     /locus_tag="VVR18_001498"
     CDS             1475..2323
                     /locus_tag="VVR18_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEU6033001.1"
                     /translation="MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITF
                     YLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSGWLAFFEHIPLHIDLQ
                     GDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCIL
                     MLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDL
                     GRGVTFISGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEG
                     FTFEKE"
     gene            complement(2416..3333)
                     /locus_tag="VVR18_001499"
     CDS             complement(2416..3333)
                     /locus_tag="VVR18_001499"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HEU6033002.1"
                     /translation="MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAA
                     RKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQF
                     ASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKG
                     KISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYM
                     PADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLD
                     RIRDMTKFDSVDQLVDQLKADEEVTRNWS"
     gene            3771..3976
                     /locus_tag="VVR18_001500"
                     /pseudo
     CDS             3771..3976
                     /locus_tag="VVR18_001500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844775.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            complement(4181..4474)
                     /gene="rpmA"
                     /locus_tag="VVR18_001501"
     CDS             complement(4181..4474)
                     /gene="rpmA"
                     /locus_tag="VVR18_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HEU6033003.1"
                     /translation="MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTG
                     GSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK"
     gene            complement(4491..4835)
                     /locus_tag="VVR18_001502"
     CDS             complement(4491..4835)
                     /locus_tag="VVR18_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HEU6033004.1"
                     /translation="MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINF
                     INSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENY
                     SEFVQTRVITEN"
     gene            complement(4851..5165)
                     /gene="rplU"
                     /locus_tag="VVR18_001503"
     CDS             complement(4851..5165)
                     /gene="rplU"
                     /locus_tag="VVR18_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HEU6033005.1"
                     /translation="MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVG
                     GENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAI
                     NA"
     misc_feature    complement(5201..5288)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00559"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L21 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00559"
     gene            complement(5353..6051)
                     /locus_tag="VVR18_001504"
     CDS             complement(5353..6051)
                     /locus_tag="VVR18_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004241810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HEU6033006.1"
                     /translation="MGGKMRLLPIRKISRQSKRLALFLTFCAGYVDAYTFIVRGNTLV
                     AGQTGNVVFLSVELIKNNVSDVRDKVLTLLAFMMGVFLLTIYKEKLRIVKKPILSLIP
                     LAILSIIIAFVPQTVDNIYLVPPLAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLA
                     FGDYFRTKHTPFLREGFIFVSLLSSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLS
                     MLFASWQKKVKEKA"
     gene            6453..6752
                     /locus_tag="VVR18_001505"
     CDS             6453..6752
                     /locus_tag="VVR18_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HEU6033007.1"
                     /translation="MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLT
                     GDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF"
     gene            complement(7093..8067)
                     /gene="pta"
                     /locus_tag="VVR18_001506"
     CDS             complement(7093..8067)
                     /gene="pta"
                     /locus_tag="VVR18_001506"
                     /EC_number="2.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="HEU6033008.1"
                     /translation="MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPV
                     LLGNPEKVKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVE
                     DVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTER
                     YLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVE
                     ATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYK
                     MAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ"
     gene            complement(8111..9007)
                     /locus_tag="VVR18_001507"
     CDS             complement(8111..9007)
                     /locus_tag="VVR18_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEU6033009.1"
                     /translation="MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQ
                     NATYLLDVGDYVTIYIPAEEGFETLEAIEHPLDILYEDDHFLVLNKPYGVASIPSVNH
                     SNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIE
                     KRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLV
                     YIHLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLEDGIQRQALHCHYLSFYHPFLEQDL
                     QLESPLPDDFSNLITQLSTNTL"
     gene            complement(9004..9822)
                     /locus_tag="VVR18_001508"
     CDS             complement(9004..9822)
                     /locus_tag="VVR18_001508"
                     /EC_number="2.7.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD kinase"
                     /protein_id="HEU6033010.1"
                     /translation="MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIV
                     ISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGAR
                     VSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVST
                     PTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRN
                     DYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE"
     gene            complement(9806..10477)
                     /locus_tag="VVR18_001509"
     CDS             complement(9806..10477)
                     /locus_tag="VVR18_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HEU6033011.1"
                     /translation="MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTG
                     RVKPIESIKEKMARRGITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRII
                     QERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYK
                     YQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDT
                     DEEYR"
     gene            10605..11174
                     /locus_tag="VVR18_001510"
     CDS             10605..11174
                     /locus_tag="VVR18_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CYTH domain-containing protein"
                     /protein_id="HEU6033012.1"
                     /translation="MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTPDFEL
                     REKKVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDAEDYLSKEELPQGLVLDEL
                     AKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDMTDYELELEVENHEQGKQD
                     FRQFLEKNQISYQKAPSKLVRFVKSMKNS"
     gene            11284..12243
                     /locus_tag="VVR18_001511"
     CDS             11284..12243
                     /locus_tag="VVR18_001511"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEU6033013.1"
                     /translation="MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQ
                     VNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDR
                     IACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD
                     KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKA
                     ILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDS
                     VATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK"
     gene            12253..13368
                     /locus_tag="VVR18_001512"
     CDS             12253..13368
                     /locus_tag="VVR18_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEU6033014.1"
                     /translation="MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKL
                     LREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVL
                     ETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFANNETGNLLPIAEI
                     GQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFD
                     SYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQ
                     YYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLEAMY
                     GANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG"
     gene            13373..13720
                     /locus_tag="VVR18_001513"
     CDS             13373..13720
                     /locus_tag="VVR18_001513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1831 domain-containing protein"
                     /protein_id="HEU6033015.1"
                     /translation="MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTR
                     LLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMD
                     SLVERGVFTKSER"
     gene            13728..13943
                     /locus_tag="VVR18_001514"
     CDS             13728..13943
                     /locus_tag="VVR18_001514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HEU6033016.1"
                     /translation="MFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLT
                     FRGQKVYQGLVGDLYRFLSHADFLHQN"
     gene            14026..14667
                     /locus_tag="VVR18_001515"
     CDS             14026..14667
                     /locus_tag="VVR18_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HEU6033017.1"
                     /translation="MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIG
                     IDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLH
                     YRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSV
                     KSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED"
     gene            14685..15374
                     /locus_tag="VVR18_001516"
     CDS             14685..15374
                     /locus_tag="VVR18_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEU6033018.1"
                     /translation="MKKPVIGITGNEKTHPDDDIMMSYAAKGFVEGVKDAGGIPIILP
                     IGDQEMACHYISLIDKLILTGGQNVDPKFYGEPKTIDSDDYHLQRDIFELALIKEAIK
                     QKKPIFSVCRGTQLFNVAMGGTLYQDIEDHWQDSSVEYTTQRLVTEPDTVLQEIYGEI
                     SHINSFHHQSIKDLAPNLKVVAHDPKDGIIEAVMSTDDVAFLGVQWHPELLFENRPKD
                     KKLFDYVVNEL"
     gene            complement(15371..16051)
                     /gene="radC"
                     /locus_tag="VVR18_001517"
     CDS             complement(15371..16051)
                     /gene="radC"
                     /locus_tag="VVR18_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000286923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HEU6033019.1"
                     /translation="MYSISFQEDSLLPRERLAKEGVEALSNQELLAILLRTGTRQASV
                     FEIAQKVLNNLSSLTDLKKMTLQELQSLSGIGRVKAIELQAMIELGHRIHKHETLEME
                     SILSSQKLAKKMQQELGDKKQEHLVALYLNTQNQIIHQQTIFIGSVTRSIAEPREILH
                     YAIKHMATSLILVHNHPSGAVAPSQNDDHVTKLVKEACELMGIVLLDHLIVSHSNYFS
                     YREKTDLI"
     gene            complement(16094..18385)
                     /gene="pcrA"
                     /locus_tag="VVR18_001518"
     CDS             complement(16094..18385)
                     /gene="pcrA"
                     /locus_tag="VVR18_001518"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000992850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase PcrA"
                     /protein_id="HEU6033020.1"
                     /translation="MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYL
                     IDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHI
                     GYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA
                     GDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVD
                     EYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVL
                     LEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYRADDELDEAVFVART
                     IDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIA
                     YLNLIANLSDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKG
                     KAAQSIWDFANMMLDLREQLDHLSITELVESVLEKTGYIDILNAQATLESKARVENIE
                     EFLSVTKNFDDTTDVTKEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMTLHAAKG
                     LEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFG
                     RTNYNRPTRFINEISSDLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKR
                     GAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALHKKWGEGTVLEVSGSGARQEL
                     KINFPEVGLKKLLASVAPIEKKI"
     gene            complement(18568..19135)
                     /locus_tag="VVR18_001519"
                     /pseudo
     CDS             complement(18568..19135)
                     /locus_tag="VVR18_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
BASE COUNT         5850 a         4044 c         3484 g         5757 t
ORIGIN      
        1 aatattttcg gaacattcaa ctttttaact ctatttatta ctaaatttca taattaaaaa
       61 gcctactgac caagctagaa agcttgatac aataggcttt ttaaagactg attatttaac
      121 agcgtcttta agagctttac cagctttgaa tgctggtact ttagaagctg caattgtcat
      181 ttctttacca gtttgtgggt tgcgaccttt acgttctgcg cgctcacgaa cttcaaagtt
      241 accaaaaccg atcaactgaa ctttttcacc agctgcaaga tagtcagcta ctgctgcaaa
      301 tacagcttca actgctgctg ctgagtcttt cttagtcaat tctgtagctt ctgctacttt
      361 agcgatcaaa tcttgtttgt ttgccatgtt aatgattcct ccaaataatt tctaattaac
      421 aaatataatc atatcctaaa atccctttta ggtcaagtta aaaacgctat ttcttcccat
      481 tttatttatt tttttaggag tggtaacgta tcaaaatagc ccaagcgttc tcacccgtgt
      541 gagtttgaat aatggaaccc gtttccaaaa cagaaattgg cttttcaaca taagcttgta
      601 agctttcttt catctctttt gcccaatcat cactaccaga atatgaaatt ccaatctctg
      661 ctacagcacg ttcagaaagc gatgttatca actcatctaa ccatttttta aatgttttag
      721 ttccacgacc tttaaccatt ggctgcaatt catggtcttt catttgcatg acagcacgga
      781 tattgagaag agagctcaac aagccagtta cacggctaat tcgtccacct ttgacaagat
      841 tttccaaagt tgaaacacca atataaagct ctgtatggtt tttaacctct tctacatgag
      901 ataaaattgc ctccatatct ttaccttctt gagctaactt cgcagcctca acaacttgga
      961 atttcagggc ttggtcagtg aaggaactat caacaacagt cacatctgca gtagataggc
     1021 tagcaccttg gcgtgctgct tctaccgtac ccgaaagagc atgggacata tgaatagcaa
     1081 gaatatggcc accatctttg cataggtctt caaaaatctc agcaaagaca cctacaggtg
     1141 gctgacttgt tttcggaaga ttcttacttt cttgcatcaa ctgaagaaat ttaccttctt
     1201 ctttcaaatc cgcatcagaa taaacaacat tatcaatcat tacagataat ggaacaattg
     1261 taatatctaa ttgctttact agttcaggtt caatagtaac agatgaatcg gttacaatct
     1321 taatttttgt catagtatca atctttctat tttaggattc agattggttt ccttacttct
     1381 aattatatca aaaaaaagat taaaaatcct aatggagtca atcaaatttt ccgtaaaatt
     1441 tgatataatc aacttataag aaaagaggtg tcctatgatt aaaaaaattt accccatttt
     1501 taccatttta ctaggtgctg ctatttatgc ttttggactg acttattttg tagttcccca
     1561 tcatctcttt gaaggagggg cgacaggcat taccctcatc accttttatc tttttaaaat
     1621 ccctgtttcc ctcatgaacc tgctgattaa tattcccctt ttcatcctag cttggaagat
     1681 ttttggagcc aaatccctct attctagttt actaggaacc ttagctttgt ccggctggtt
     1741 agcttttttt gagcatattc cccttcatat tgatcttcaa ggtgatttac taatcacagc
     1801 ccttatagcg ggaatcctat tgggaattgg ccttggaatt atttttaatg ctggaggtac
     1861 aactggcgga actgatattc tagctcgtat tctcaacaaa tacactcata tatccatagg
     1921 aaaactgctc tttatcttag atttttgtat tctcatgttg attctcctaa tcttcaagga
     1981 tttgagattg gtttcctaca cgcttttgtt tgattttatt gtttctcgtg ttattgattt
     2041 gattggtgaa ggaggatatg ccggcaaagg ctttatgatt atcacaaaac gtcctgacca
     2101 acttgctaag gcgattaatg atgacctcgg aagaggtgtt acttttattt ctggtcaagg
     2161 ctactatagt aaagaaaatt tgaaaatcat ctactgtatt gtcggaagaa atgaaattgt
     2221 gaaaacgaag gaaatgattc atcgaatcga tcctcaagcc tttataacta ttacagaagc
     2281 ccatgaaatc ctaggagaag gcttcacctt tgaaaaagaa taaaaagagg taatgtcgtg
     2341 acctcaaaag ttagactaaa tcatctatct tttgggttac agacaacctc ttttttattt
     2401 tatttactca agctcttaag accaattccg agttacttct tcatcagcct ttaactgatc
     2461 cactaattgg tcaactgagt caaatttggt catatcacga atgcgatcaa gccaataaac
     2521 catgacggtt tccccataaa tatcttgatt aaaatcaaaa atattgactt caaaacgtgc
     2581 ttcttctcca tcaaaggtca catttttccc gacactagcc atagcacgat acttctgtct
     2641 ttgaatctca acatcaacga cataaacgcc atctgctggc atataagtac ggtctaaaag
     2701 cactaaattc gctgtcggat aaccaattgt acgaccacga gcattaccat gaaccaccat
     2761 acctcttgat ggaagcggtg cccccaaaag ttttcctgct tctttcacat ttccatctaa
     2821 aatagcttga cggatacgag ttgaactaat ctttcctttc tcatcttcta caggtggaac
     2881 aatgataact tctccatcaa agtaatcctt taaatcttct gctgtttttt tgtcagaacc
     2941 aaatgtataa tcaaaacctg caacaataat tttggcattc atagccttga tataagttgc
     3001 aaagaattct tgtgcagtga gactagcgaa ttgactacta aaatcaagga gatataattc
     3061 ttctacacct tcgcgcttta attttctttc acgttcagca gggttcaaaa tatgcaaaaa
     3121 caaatctgga tgataaggct ctaaagcgat ctttggagat tcattaaagg tcataacgac
     3181 gataggtaat aaatcctttc tcgcagcctt gttggcaaca cgaaataatt cttgatgccc
     3241 cttatgtatg ccatcaaaat agccgagaac aacgactgaa tcagatggtg tgccaatatc
     3301 tttttggttt tttataggaa tagtaataat cataaaataa ttatatcata gcgatagcta
     3361 tttctggaac agaaaatctg aaatgttgtt tttttcacat gaagtgtacc tgttttcaaa
     3421 aagcacttta ttctatcgtt gcttaactat gaactttgca atattcttct caaaaacttg
     3481 taggacatct tcaaaatttt gcaaggagtg attagacttg ttcggtaacc ataaagtgtc
     3541 atactatgct tatgtatgaa aaagcaatgc aactaactcc tgagaacttt aaattactaa
     3601 ttggtgccga aaaggtagaa tttagaatcg aggtacacct atggctgtaa aatttacaaa
     3661 atgagacaac ttgggcaaga tgtttgaaga atttcctaaa ctccctgatt tgaagcaagt
     3721 cactttccct gatgacaaag aaaaaagcca aaacagcaaa gaaaaactag atgactgctt
     3781 tccaacaact cccatctagt gtgcttcaga ctgggctatt tttctctcca tctgttagct
     3841 tggattctca gacagtttca gctaaagaat atcttttccc ttatcagaag gaacggctca
     3901 aaccattcag acaagtgaag ggacgacaag ccaatatttg aaaccagata gcagttctta
     3961 tagtcaattg aaataaaatc tgaagaaatc gagtaggaaa ctcatatcaa tttttaacag
     4021 tgttctattc cagattcaat ccactataca tattaaaaag tatgggtacc aaaacaaaaa
     4081 aacaggctct ccgaaaactc ggaaagcctt attttaagct gtttctagct tcctcacctt
     4141 tacatttcaa ggttcgggat aaaaggttca atggaccttt ttatttagcg attgggtaaa
     4201 cagaaacttg ttttttatcg cgtcctttac gttcaaagcg tactacgcct tcaactttag
     4261 cgaacaaagt atcgtctcca ccacgaccaa cgtttacacc tggatagatg tgtgtaccac
     4321 gttgacggta aaggattgat ccacctgtta cagtttgtcc gtcagctgct ttagctccaa
     4381 gacgttttgc ttgtgaatca cgtccgtttg atgtagaacc tccacctttt ttgtgggcga
     4441 aaagttgcaa gttgttaaga gtcattttta acataatgtt ttcctccgtg ttagttttct
     4501 gtgataactc tggtttggac gaactcagaa tagttctccg ataagtttgc catacctaag
     4561 aaaaatgatt caaagaataa ctgggtcatt tctctctggt gtgaaggaag atcttttggt
     4621 atttcaacca tcagatagcc accttcatct tcgtttaatt ctaggattgg ttcatagcct
     4681 gcaaatttct caatagaatt gataaagtta atggcaagcg tagaaaccga tgcacacacg
     4741 acatctaagc cgtattcgcc actctcggcg tgtccagtaa tttccgcact cctcagctcg
     4801 ccatcttcgg ctctctcaaa gactgcctgt atcatgtgtt ctccttaaaa ttaagcgttg
     4861 attgcgttga tgacaacttt tgtatatggt tgacggtgac cttgtttacg gtggctacct
     4921 tttttaggtt tgtacttgta agtaaccact ttcttttgtt ttccttgttt ttcaacagtt
     4981 ccaactacag tagctccagc aacaagtgga gttccgacaa cagtgttttc accaccaaca
     5041 agaacaactt cgttaaaagt aacttcttga ccagcttcaa cgttcaattt ttcaacgtaa
     5101 actgcttgac caacttcaac tttaacttgt tttccgccag ttttgataat tgcgtatgtg
     5161 ctcattatgc acctcctatg atttttatgg gtttccccga ttttttgtga agactcgcct
     5221 agcatcgtgg gacgaaccac ttaaacttga ataatcaagc aacgatgttc gtgcggttgc
     5281 acaggatcgt gcatagtcaa ctcttcaagt atagcatatc tcctattttc ttacaagtaa
     5341 taacacctaa aatcaagctt tttcttttac ttttttctgc caagaggcaa aaagcatgct
     5401 gaggtaaaaa acgctcatca taataggaac accaagaatg gtcttttcat gatagaaaat
     5461 cgtcaaatag gctgaaaaga caacgccaag gacaaaacta ctaagcaggc taacaaatat
     5521 gaatccttca cgcaaaaaag gagtgtgctt ggttcggaaa taatctccaa aagccagcat
     5581 ggtccgtttg atattccctg tcataaaagc gttattatag gcaatacccg acacttctcc
     5641 aaaagcagtt gtcaccagtc ccatacagaa ggccaagggc ggcactagat agatattatc
     5701 cacagtttgc ggcacaaaag caataatgat tgataagatt gccaagggaa tcaaggacag
     5761 aataggtttt ttcacaattc tcaatttttc cttataaatc gttaataaaa agactcccat
     5821 cataaacgct agcaaggtga gaaccttgtc cctaacatcc gaaacattat ttttaattaa
     5881 ttctactgaa agaaagacaa catttccagt ttgtccagct acaagggtat tcccgcgaac
     5941 aataaaagtg taagcatcca catatccagc acaaaacgtc aaaaaaagtg ctaacctttt
     6001 agactgacgt gatatttttc ttataggtaa taacctcatt ttacctccca ttgtattttc
     6061 tcttagaaat attgtaccat tttctttcta aaaaatcgta ggctaccatt tagattttac
     6121 tattagcata aaaataataa tagacaacta tttatccaaa aatagataga tgtaacatgt
     6181 ttgcaaacaa agcatacgaa cctttagtaa aatcatttcc atgaaactag aatagagccc
     6241 tcttagcaaa aatcattatt ttaatttatt tctaatcact ccttgacata aataactctc
     6301 accaataaaa gactatgtct taaaaaaatg gtataataaa atcaatactt gggcttgatg
     6361 gctatgctac taataacaat taggagagaa aatcaggcac ttgttaacaa caaggattat
     6421 ccccttgaga tgaaaggaac tttagaaatc ttatgatgaa catgcaaaac atgatgcgtc
     6481 aagcacaaaa acttcaaaaa caaatggaac aaagccaagc tgaacttgct gctatgcaat
     6541 ttgttggcaa atctgctcaa gatcttgtcc aagcgacctt aactggcgat aagaaagttg
     6601 tcagcattga tttcaatcca gctgtcgttg acccagagga ccttgagact ctttctgata
     6661 tgaccgttca agccatcaac tctgctcttg aacaaatcga tgaaactacc aagaaaaaac
     6721 tgggtgcttt cgctgggaaa ttacctttct aaaaacaagg agctagaaca atgcttgtcg
     6781 ataacaaaga ttaagaaagg tgcaaaaatt ataaaaaacg cataatagca ggtgtcaaga
     6841 cacttaatat tatgcgtttt ctcatgaaaa attctctttt catactcatt taaaatcaaa
     6901 aagggaaatt atcgttttac ggacatacat attacagatt tctataggtc gtgtatagac
     6961 aggatatcat cgcttggaag ttttcctttt tgacaccaat cagtaattta gttctcagga
     7021 attaatggca gtgcttttcg tacatagttt cataactaca gtatagcata gtatatcgct
     7081 ttatagtttt cactattgat gaactgcttg agctgctgtg atgagggtca acttgtaaac
     7141 atcatctgca ttacatccac gagaaagatc attaactggc ttgtttaaac cttgcaaaac
     7201 aggtcctaca gccgcaaagc cacccaggcg ttcagccatc ttgtaaccga tatttcctgc
     7261 ctcgatacct gggaagatga agacatttgc ttgaccagct accgtacttc caggagcttt
     7321 cagagctgca gtttcaggaa caaaggctgc atcaaattgc aactcaccat cgatttcaag
     7381 gtcaggacgc aagtcgtgag caattttagt tgcttcaacg accttatcaa cgctttcacc
     7441 aaaccctgaa cctttagtag aatagctcaa catggcaatt ttaggttcga tgccaaacat
     7501 cttagctgtg attgctgagt tgatggcaat ttcagccaag gcttctgcat ctggattgat
     7561 gttaatggca cagtctccaa ataggtaacg ttccgtacca cgaaccatga ggaaggctcc
     7621 tgaagtacga gttacatttg gacgagtttt gatgatttgt agagctggac gaactgttga
     7681 agctgttgag tgaatcgctc ctgacaccat tccatcaacc aagcccaagt aaaccaacat
     7741 cacaccaaag tagttgacat cttcaaccaa aaccttgcgt acatcttctt cagtcatttt
     7801 gcccttgcga cgctccacca aggcagaaac catttcttca aattgaggat aatgttgagg
     7861 gtcgatgacc tcataaccat ccatgattcc ttcaatttca agataaattt taactttttc
     7921 aggatttcca agcaaaacag gaatcacttc tgtttctttt actaagcgtt ttgttgcttg
     7981 aagaatacga ggctcttccc cttcagggag aacgatacga gcatttttac caacaaggtt
     8041 ggctttgaga ctttcaaaaa cttccatgag ttttctcctt taagataata attatactct
     8101 gagacagttt ttatagagta ttagttgata actgggtaat aaggttactg aaatcatccg
     8161 gcaagggact ttctaactgc aagtcttgct ctaaaaatgg atgataaaag gataggtaat
     8221 ggcaatgcag agcctgacgt tgaataccat cttccagact accaccatac aaatcatctc
     8281 ccagcaaagg aaaaccgata tgagaaaaat ggactcggat ttgatgggtt cgaccagtgt
     8341 gcaggtgaat atagaccaag tgaatatttc cataagaagc tacaatcttg tatgaagtat
     8401 gggcatactt tccgccttta gccactcgtc tggtaataat ggaatcttca tcacgcgcaa
     8461 tcggagcaat aatttcccct tctggctcca aatgtccatc tcccttaacc aaagcaaagt
     8521 agcgtttctc gatagatttc ttctgcaact gcttgtctaa tcgtgcatgg gcataaccgt
     8581 gcttggcaaa gagcatcaag ccagaagtgt ccctatctag tctggtaaca atgtgaacct
     8641 gctgattttc ataattttgc ttgacatagt aacccttgat aaaattggca atggtattag
     8701 agtgattgac actaggaata gaagccactc catagggttt attcaagact agaaagtggt
     8761 catcctcata gagaatatct aatggatgct caatagcctc caaggtttca aagccttcct
     8821 cagcgggaat gtaaatggta acgtagtctc caacgtccaa tagatacgtt gcattttgcg
     8881 gttgattatt gaccagaata gctccacctc gaaacttaat cttagccagc aatcccttag
     8941 aaacctcgtg cttttttaaa aaggtcttaa ccttgacatg ttcatctgcg ataaattcaa
     9001 acctcattca tccacctcac cgataaaggc atccttaaca cggttccaga aactggtatg
     9061 gctaggagtc gcgacaaagt gaatcttatg atggtcgatt tgatactcaa tacgctcaat
     9121 attacggaaa gaataaacgc tattgtcaac cgaaatagta tgataatcgt ttcttgttgg
     9181 aataagttca atcttatcct tcttaggcac aataatggaa gagcccagtg ttcgataaac
     9241 acgattatta aggctggcaa tttccgttaa ttgcaaagct tcaatggtag ggtgtaaaac
     9301 agcaccgcca agagacttgt tataggcagt actaccagtc ggtgtcgaaa ctgttagccc
     9361 gtctccacga aaacgttcaa agggaacacc atttattaca atatctgcca ccatggttcg
     9421 atcagacctg cggatgctgg cttcgttgag tgctctgaaa atcttaactt caccattttc
     9481 aagaaagacc ttcacattca gaacagggta agaaaccctt gccccagtat ctagctgcaa
     9541 attagtcact agcttgtcca actcaaaatc acgataatct gtatagaagc ccaaatgtcc
     9601 agtatgaaga ccgataaagc ggaccttgtc aagctgattt tcgtacttat gaaaggccga
     9661 caagagcata ccatccccgc caatggaaat gacaatatcc ggattggtat cattgagtat
     9721 aaactgattt ctcttcaaac gatctcgcaa ttcatacaaa accctttgac tctgcggttt
     9781 tctattggct atcagatcaa ttcgtttacc tgtattcttc atctgtatcg tcactgtttc
     9841 ctacaccgtc atttaatttt ctactcaaag gatcaaaaag tgcctgggct tcttggatat
     9901 catcacgaat ttcacccatt tcttcatcca actgatgggc gattctagct gtaatttcca
     9961 gtcgcttctt aatctcatct gggaaatccc cttggtactt gtagttgaga gaatgttcta
    10021 tcgttgccca gaaattcata gccaaagtac gaatttgaat ttctgccaaa atagtcttag
    10081 ctccattgat ggtatcaacc gtatattcta ctaccacatg ataggaacga tagcctgatg
    10141 cttttctatg agtaatgtaa tctcgctcct gtatgattcg catatcctga cgcttgtgca
    10201 aaatatccac tacttccttg acgtcatcta caaactgaac catcacacgt aagccagcaa
    10261 tatcctgcaa atcgtgttcc aaggtcgcat aagtaatgcc acgacgagcc attttttctt
    10321 tgatgctctc aattggcttg actcgaccgg tcacaaactc aattggagaa tgcttatttt
    10381 gcttacgata ttgcttacga ataccacgaa gtttaatctt taactcacca acagcttgaa
    10441 tgtaaggatc tagaaattct tcccattcta aggtcatata ttctcccttg ttctcatatt
    10501 atccgtcaaa aatatctttg attttttctc cagattcata tacaataaat acaatgctta
    10561 ttataccata aatccgcttt caacgataaa aaaaggtaag aaaaatgaaa catttagaaa
    10621 ttgaattgaa aacactattg aaaaaagatg aatacaatcg tctaaaagac cagttcacag
    10681 gtgtcactcc tgttcttcaa acaaattact acatagacac gcctgatttt gaactgcgag
    10741 aaaagaaagt cgctatgcgc attcgaacct ttgaagactg ggctgagttg acactcaaag
    10801 tcccgcagag tgttggaaac atggaataca accaaaaatt gcaactaaaa gatgctgagg
    10861 actatctgag taaggaagaa cttcctcaag gactagtact ggatgaattg gcgaaacatg
    10921 gtatccaaag taagaactgg caggttcttg gttgtctaac aacgcttcgc tatgaaatga
    10981 aaacagctat tggtctcatg gcactggatc agagccgata ctttgatatg acagattacg
    11041 aattggagct tgaagtggaa aatcatgagc aaggcaaaca ggatttccga caatttttag
    11101 agaaaaatca gatttcctac caaaaagctc cttcaaaatt ggttcgattt gtcaaaagta
    11161 tgaaaaatag ctgaaataat ctccattttt tggtaaaata gaaaagataa aaatacacaa
    11221 accctagtta tatgtaaggt aaatataact aggatttata aagtttacag aggacggtct
    11281 ataatgtcag atagaaaaaa catgaaactt ttcgcactca actctaacca agagattgca
    11341 cagaaaattg cccaagctgt tggtgtccca cttggaaaac tatcatcacg tcaattttca
    11401 gacggagaaa tccaagtaaa tatcgaagaa agtgtccgtg gttatgatgt ttacatcatc
    11461 caatcaacaa gtttccctgt caacaaccac ctaatggaac tgttaatcat ggtcgatgct
    11521 tgtgtgcgtg caagtgccca cagtatcaac gttgtccttc catattttgg ctatgcacgt
    11581 caagaccgca ttgcttgtcc tcgtgagcca cttacagcaa aactagttgc caatatgctg
    11641 gttaaggctg gagttgatcg tatcctgact cttgatttgc atgccgttca ggttcaaggt
    11701 ttctttgata ttccagtgga taatcttttc actgttcccc tattcgcaaa acattactgc
    11761 gataaaggat tgcttggttc agatgttgtt gtcgttagcc ctaaaaattc aggtgtcaaa
    11821 cgtgcgcgta gcctggctga atatcttgat gctcctatcg ccattatcga ctaccctcaa
    11881 gacgatgcaa ctcgtaacga aggttatatt attggtgatg ttgaaggtaa gaaagctatc
    11941 ttgattgatg atattttaaa tacaggacgt accttctctg aagcttctaa aatcgttgaa
    12001 cgtgaaggag ctacagaaat ttatgctgtt tctagccacg gtctcttcgt cgagggagct
    12061 gctgagcttc ttgacaatac taatattaaa gaaattcttg tgactgattc agtagcaaca
    12121 aaagaaaaaa ctcctaaaaa tgtatgctac atcactgcta gtgagttaat tggtgatgct
    12181 atcgtccgta ttcacgaaag aaaaccagtc agcccactct ttgcctacaa taaaaagaaa
    12241 taaggtgatt ctttgattta tttggacaat gctgcaacga ctcctatgtc agcagttgct
    12301 atttcagcta tgaccaaggt tatgcaagaa acccacggaa atccttctag tattcatggt
    12361 catggtcgtc aagctggcaa actcttgcga gaagcccgtc aggaactagc ccagttacta
    12421 aggacaaaac ctcaacatat ctttttcact tctggtggga ctgaaggcaa taatactacc
    12481 atcattggct actgtcttcg tcaccaagaa caaggaaaac atatcatcac aactgccatc
    12541 gagcaccatg ctgtccttga aacaattgat tacttggttc aacactttgg gtttgaagca
    12601 accattatcc agccagaaaa tcaagaaatc acagcccagc aaattcaaaa ggctttacgt
    12661 gacgatacga ttttggtttc taccatgttt gccaataatg agacaggaaa cctactgccc
    12721 atcgctgaaa ttggccaaat actcaagcaa caccctgctg cctatcatgt tgatgcagtt
    12781 caggctattg gtaaaatccc aattcattca gaagaattgg gcattgattt tctcactgct
    12841 tctgcccaca aattccatgg tcctaaggga atcggttttc tctacgcatc tagcatggac
    12901 tttgattcct atctacatgg cggagaccag gaacagaaaa aacgtgcagg aactgaaaat
    12961 ctgcctgcca tcgtaggcat ggttgcagcc ctaaaagaag acctagaaaa acaagaagaa
    13021 cattttcaac atgtacaaaa tctagaaact gcctttctgg cagagctgga gggcattcag
    13081 tattacctga atagaggaaa acatcatctc ccttatgttc tcaatattgg atttcctggt
    13141 cagaaaaatg acctcttact ccttcggcta gatttagctg gaatttcaat ctctactggc
    13201 tcagcctgta ctgcaggcgt tgtccaatcc agccatgttc ttgaagccat gtatggcgca
    13261 aattcagaac gcttgaagga atcccttcgc atcagtttgt cgccacaaaa taccgttgaa
    13321 gacctacaaa ccctcgcaaa aaccttaaaa gaaattatcg gaggttagcc atatggcatt
    13381 tgaaaaaatc attcagttaa aaaattgtcg ttacgattac actcttagcc cttctgttaa
    13441 aaaattcacc ctcaaagata acaccttttt tgaaactaag gttggtaact atgaactgac
    13501 tcgccttttg gaaaaagtgc caaacagcgg tgaaggcttc caactcaaaa tcatcattaa
    13561 caaggaactt acaggggcta aaatcaatat cactgacaag tttggccttc gtctagttga
    13621 tattttcaaa tcagaagacc accatattca tcaggaaaaa ttctacttcc tcatggatag
    13681 cttggtagaa cgtggtgtct ttacaaaatc ggaaagatag agccaaaatg tttgaactga
    13741 cctataagga ctgctatcat gtagagcgta ctctcaagta tgaggatcat gaggctctca
    13801 tgttgacttt gtcaggatgt gtaaccttac cagatacact ttatgtgact tctctgactt
    13861 ttaggggcca aaaagtttat cagggtctgg tcggagacct ctaccgtttt ctatctcatg
    13921 cagatttttt acatcaaaac taagattttt cttagttttt tcttattttt gttgattttt
    13981 tcacaatgtt tctataaaat agaagaatag aaaggttgtg attttgtgaa agataaacag
    14041 tttgctattc caaaagctac agcaaaaaga ctctctctct actatcgaat ttttaagaga
    14101 tttcatgcag aaaagattga acgtgccaac tctaagcaaa ttgcagaggc cattgggatt
    14161 gattcagcga ccgtacgtcg tgatttttcc tattttggtg aacttggtcg tcgtggtttt
    14221 ggctatgatg tcaaaaaact aatgacattt tttgccgatt tgctcaatga caactctatt
    14281 accaatgtca tgctggttgg tattggaaat atgggccatg cccttctcca ctaccgcttc
    14341 cacgaacgta acaagatgaa gattatcatg gcctttgacc tagacgacca tcctgaagtc
    14401 ggtacccaaa ctcctgacgg gattcccatt tacgggattt ctcagatcaa ggataaaatc
    14461 aaggatgctg atgtgaagac tgctatccta actgttccca gcgtcaagtc acaagaggtt
    14521 gctaatctct tggttgatgc tggtgtgaaa ggaattctca gtttttcacc agtccatctg
    14581 catttaccaa aagacgtggt cgttcagtat gtcgatttga caagtgaact ccaaaccctc
    14641 ctctacttca tgcgaaaaga ggattagaaa gcgaaaatca ttttatgaaa aaaccagtta
    14701 ttgggattac aggaaacgaa aaaactcatc cagatgatga catcatgatg agctacgcag
    14761 caaaaggctt tgttgaaggc gttaaagatg ctggagggat tcccatcatc ctaccgattg
    14821 gtgatcaaga aatggcctgc cactatatca gtttgattga caagctcatc ttgacaggtg
    14881 ggcaaaatgt cgatccaaaa ttctatggcg aacccaaaac cattgatagc gatgattatc
    14941 accttcaaag agatatcttc gaactggccc tcatcaagga agctattaaa cagaaaaagc
    15001 ccattttctc tgtctgccgt ggtacccaac tctttaacgt tgccatgggt ggaactttgt
    15061 accaagatat cgaagaccat tggcaggatt cttctgttga gtacacaact caacgcttgg
    15121 taacagaacc agataccgtt ctccaagaaa tctatggaga aatctctcat atcaactcct
    15181 tccaccacca gagcatcaag gacttagcac caaatttaaa agttgtggct catgatccta
    15241 aagatggtat cattgaggct gtcatgagta cggatgatgt cgcctttctc ggtgtccaat
    15301 ggcatccaga acttcttttt gaaaatcgtc ccaaagataa gaaactcttt gactatgtcg
    15361 ttaatgaact ttagattaaa tctgtctttt cacgataact aaagtaatta gaatgagaga
    15421 caatcaaatg gtccaagaga acaatcccca tcagttcgca ggcttcttta acaagtttag
    15481 tgacatgatc atcattttgg ctaggcgcta ccgctcctga aggatgattg tggaccaaga
    15541 taagagaagt cgccatatgc ttgattgcat agtgaagaat ctctcgcggt tcagcgatac
    15601 tacgagttac agaaccgata aaaatggtct gctgatggat gatttgattt tgagtattga
    15661 gatagagtgc caccaggtgc tcttgttttt tatcccctaa ttcctgctgc atcttcttgg
    15721 ccaacttttg actgctgaga atactttcca tttcaagagt ctcgtgtttg tgaatacgat
    15781 gccccagttc aatcatagct tgtaattcta tggccttaac acgcccaata ccagacaaac
    15841 tctgcaattc ctgcagggtc atttttttca aatccgttag gcttgaaaga ttgtttaaga
    15901 ctttttgggc aatttcaaaa acgctagctt gacgtgttcc tgtcctgagt aaaatagcta
    15961 gcaactcttg gttactaagc gcttcaactc cttccttggc cagcctttct cttggtaata
    16021 gtgaatcttc ttggaatgaa atactgtaca taaaaatcct cctcacttta ttattcgtga
    16081 gaaggatgga aaattagatt tttttctcaa ttggagccac actggctaaa agttttttca
    16141 aacctacttc tgggaaattg attttcaatt cctgcctagc accgctacct gaaacttcca
    16201 gaacggttcc ctctccccat ttcttgtgga gagcaatatc accaatggac caatttgcct
    16261 cgctagatgc tggttttgcg ccagctgtaa attgaccaaa tggaagaccg cttgactgga
    16321 ttgattttgg ggcagcaccg cgtttacggt cttgaagagc ctgagccaaa ctcatacctt
    16381 gaccaaagga aatactacca ctgctatatg atgccttaaa gcttgtattt gcaggacgag
    16441 ccagaccttg atactcaagc aagtctgaac tgatttcgtt aataaaacga gtcggacggt
    16501 tataattggt acgaccaaaa agcaagcgtg agttggcatt ggtcagatag agaattttct
    16561 ctgcacgcgt gatacctaca taggctagac ggcgctcttc ttctaattca tctggatctt
    16621 cagtcgcacg actaagtgga aagacatttt cttccatccc aatcaaaaag acaactggaa
    16681 attcgagacc tttggcagca tgcagggtca tcaaggtcac ttctgatgtc tcctgactac
    16741 ctgaatctgt gtcggcaatc aaagccaagt catttaagaa acgactcagt ttgtccagac
    16801 cagtttcctc ttttgtcaca tcagtggtgt catcaaagtt cttcgtaaca gaaagaaact
    16861 cttcgatatt ttcaacccgt gccttgcttt ctagagtcgc ttgggcgtta agaatatcga
    16921 tataacctgt tttttctagg acggactcaa ccaactctgt aatgcttaag tggtctagct
    16981 gctcccgcaa atcaagcatc atattggcaa aatcccagat agattgggct gccttaccct
    17041 tgataccaga caacataata ttagcagaag catccagcat agacatattt tgcaaatttg
    17101 caaaatcacg gattttctca actgtaccta gaccaattcc acgtttaggc tcgttgataa
    17161 tacgctcaaa actaatgttg tcactcaaat tagcaataag gttgagataa gcaataatat
    17221 cgcgaatttc cttacggctg tagaatttcg ttccgccaac catggtataa ggaatgttag
    17281 acttgagcag ggcttcctca attgtacggg actgggcatt agtccgatag agaactgcaa
    17341 aatccttatg aaggaagttt tgactgcgac taagttcatc gatggttctg gctacaaata
    17401 cagcctcatc cagctcatca tcagcacgat agtaaacgat ttgctcccca tcagcgtttt
    17461 gagtccagag atttttagga cggcgatttt tattattttt aataacctcg ttggccgctt
    17521 ggagaatggt tttggttgag cggtaatttt cctccaacaa aacaacctta gctttggggt
    17581 aatccttttc aaagtccaag atattctgca tatcagcacc acgccaaccg tagatagact
    17641 ggtccgcatc cccaaccaca cagatatttt taaaacggga agccaagagt ttgaccaatt
    17701 ggtactgagc gtggttggta tcttggtact catcaacgtg gatgtattgg aatttttgct
    17761 ggtagtaggt caaaacatca ggattttgat caaagagacg caaggtcagc ataatcaaat
    17821 catcaaagtc aacggattca gactgacgaa gttctttttg ataggctgta taacactggg
    17881 ccacaatttg cgtatacata tcgccagctt gggcagcata agcaacatca tcaatcaaat
    17941 cattcttagc attggaaatg gtccccaaaa tagttcgttc attccatttt ttaggatcca
    18001 agttcaactg tttgagaata cgtttcatga gcgttcgctg ttcaccagga tccacaattg
    18061 taaaattacg attgtagcca atatggtccg catcgcgacg caaaatacgc acacacatgg
    18121 agtggaaggt cgcaatcaga cagtcctgag tagctggatt gaggctataa gcacgctctt
    18181 tcatctcacg cgcagccttg ttggtaaagg taatggccaa gatattccaa ggattgacca
    18241 gcttttcatc aatcaaataa gcgatacggt gggttaaaac acgagtcttt ccagaaccag
    18301 ctcctgccat gattagcaag ggaccttctg tcgtttgcac cgcctcagcc tgacggtcat
    18361 tcattccatt taataatgcg ttcatcttct cttccttact cttgaagtca atatttctat
    18421 tatatcagaa atcagggaaa atagaaactt tacggggagt agcaaaatat agtggattga
    18481 aactagaata ctacactgtg ggtttctaaa acactcgact tttcacccaa ttttttcata
    18541 aactagctca atagacttcc tgcaaaacta gaatcctagt tcatgattga taatgccagc
    18601 aatcaaattc attcgtaatc cgaagcgttt acgatgattt cgatagattg ttgaaaacat
    18661 tttaaacgtt tttactttgg caaagacgtt ctcgaccttg cttctctcct tagatagcgc
    18721 atggttacag gctttatctt cagctattag cggcttgagt ttgctggatt tacgtggagt
    18781 ttgtgcttga ggatatatct tcatgggccc ttgataacca ctgtcagcca agattttacc
    18841 agcttgtccg atatttctgc gactcatttt gaacaacttc atatcatgac aatagttcac
    18901 agtgatatcc aaagaaacaa ttctcccttg acttgtgaca atcgcctgag ccttcatagc
    18961 gtgatatttc tttttacttc cgtcacatca atcattaccg tgtcctcaga actgagagga
    19021 gttcttgaaa tcgtaacacc actttgaaca agagttactt caacccatta gctccgacgg
    19081 ataaagttgc tttcgtggat accaaaaaca gccgcaattt cttcataagt tcgat
//
LOCUS       DAVHSO010000044        18552 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.044, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000044 DAVHSO010000000
VERSION     DAVHSO010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18552)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18552)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18552
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.044"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            122..277
                     /locus_tag="VVR18_001520"
                     /pseudo
     CDS             122..277
                     /locus_tag="VVR18_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
     gene            477..3752
                     /gene="rexB"
                     /locus_tag="VVR18_001521"
     CDS             477..3752
                     /gene="rexB"
                     /locus_tag="VVR18_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="HEU6033021.1"
                     /translation="MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKER
                     AVLECLSQQASFSITVTRFAQMARYLVLNDLPVKTTLDDIGLGLAFYKCLAELDPKDL
                     RVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRTDLLLIFEKVTAYLNQ
                     GQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVI
                     GAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLE
                     SSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILL
                     GDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLL
                     RTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAP
                     LETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVL
                     EQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYA
                     IGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSA
                     RKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSL
                     VAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPTSPSSKTLAKDTLQALY
                     PAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQL
                     PNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIE
                     TIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPH
                     FFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKY
                     QGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYT
                     ENGRSIAPYVQQHQAITGFEANYHLGQARFLKKLDLADSKRLVGEKLKQAWLEKIREE
                     LNR"
     gene            3749..7399
                     /gene="addA"
                     /locus_tag="VVR18_001522"
     CDS             3749..7399
                     /gene="addA"
                     /locus_tag="VVR18_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HEU6033022.1"
                     /translation="MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNIL
                     VSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQET
                     DDVELKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLE
                     NEVFHEVFEAHYQGKQKETFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWL
                     SESFLKGFEKADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLI
                     LDEIGSLNQESDSQAYQAVLAHVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQ
                     FAKLGQLSDQITILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADIS
                     HYTIEILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQS
                     IYRFRQADPQIFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVG
                     EINYDNMHQLVFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEI
                     LKLHQEKGVAFKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLD
                     TLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMAS
                     SQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIWKIYNDRFYYDYVGALPNGPA
                     RQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIH
                     KSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIK
                     LSIPSLSYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLEAKQYPAAQ
                     NGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREVIGELETKSPLQ
                     DSSQADNRQSDTIKEALEMLKEVAVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGV
                     EIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLK
                     QVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVR
                     GILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLI
                     LLGKDEVQVVKV"
     gene            7569..8747
                     /locus_tag="VVR18_001523"
     CDS             7569..8747
                     /locus_tag="VVR18_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033023.1"
                     /translation="MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSLIFNGIGRSNC
                     VCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKA
                     QKKEKIKVNKSDFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEL
                     KKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAK
                     QYVDNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERAIKAKQYQKELE
                     KDQRIASQDPIERKQNQTWLLNSYFRELPEEKARFSRLLLEYRKSGEVPFSTEYLSDH
                     LIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLERLLI
                     "
     gene            8956..14787
                     /locus_tag="VVR18_001524"
     CDS             8956..14787
                     /locus_tag="VVR18_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU6033024.1"
                     /translation="MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQE
                     TAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQSQLAELPNTGSK
                     NEMQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLL
                     NYNTDYKLTSGEKLPLPKDISGYTYIGYIKEENITSESEVSNQKSSVATPIKQQKVDY
                     SVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQL
                     AEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEI
                     QENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPIPRIVEKGTK
                     KTQVIKEQPETGVEHKDVQSGAIVEPALQPELPEAVVSDKGVPEVQPALPEAVVTDKG
                     EPAIQPELPEAVVTDKGEPAVQPELPEAVVSDKGEPEQVAPLPEYKGNIEQVKPETPV
                     EKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQEAENPVQPAEESTTNSEKVSP
                     DTSSENTGEVSSNPSDSTTSVGESNQPEKNRTATKPENSGNTTSENGPTEPSNGNSTE
                     DVSTESNTSNSNGNEEIKQENELDPDKMVEEPEKKLELRNVSDIELYSQTNGTYRQHV
                     SLDGIPENTDTYFVKVKSSAFKDVYIPVASITEEKRNGQSVYKITAKAEKLQQELENK
                     YVDNFTFYLDKKAKEENTNFTSFSNLVKAINQNPSGTYHLAASLNANEVELGPDERSY
                     IKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSLKNVAISGKNDIGSLANE
                     ATNGTKIKQVHVDGVLAGERGVGGLLAKADQSNIAESSFKGRIVNTYETTDAYNIGGL
                     VGHLTGKNASIAKSKATVTISSNTNRSDQTVGGLAGLVDQDAHIQNSYAEGDINNVKH
                     FGKVAGVAGYLWDRTSGEEKHAGELTNVLSDVNVTNGNAITGYHYTGMKVANTFSSKA
                     NRVFNVTLEKDEVVSKESFEERGTMLDASQIVSKKAEINPLTLPTVEPLSTSGKKDSD
                     FSKIAHYQANRALVYKNIEKLLPFYNKSTIVKYGNLVKENSLLYQKELLSAVMMKDDQ
                     VITDIVSNKQTANKLLLHYNDHSSEKFDLKYQTDFANLAEYNLGNTGLLYTPNQFLYD
                     RDSIVKEVLPELQKLDYQSDAIRKTLGISPEVKLTELYLEDQFSKTKQNLGDSLKKLL
                     SADAGLASDNSVTRGYLVDKIKNNKEALLLGLTYLERWYNFNYGQVNVKDLVMYHPDF
                     FGKGNTSPLDTLIELGKSGFNNLLAKNNVDTYGISLASQHGTTDLFSTLEHYRKVFLP
                     NTSNNDWFKSETKAYIVEEKSTIEEVKTKQGLAGTKYSIGVYDRITSATWKYRNMVLP
                     LLTLPERSVFVISTMSSLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDHYDY
                     WYRILDEQSREKLYRTILLYDAYKFGDDTTSGKATAEAKFDSSNPAMKNFFGPVGNKV
                     VHNQHGAYATGDGVYYMSYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRNGLGPEFF
                     AKGLLQAPDQPRDATITINSILKHSKSDSTEGSRLQVLDPTKRFQNAADLQNYVHNMF
                     DLIYMMEYLEGQSIVNKLSVYQKMAALRKIENKYVKDPADGNEVYATNVVKELTEAEA
                     RNLNSFESLIDHNILSAREYQSGDYERNGYYTIKLFAPIYSALSSEKGTPGDLMGRRI
                     AYELLAAKGFKDGMVPYISNQYEEDAKQQGQTINLYGKERGLVTDELVLKKVFDGKYK
                     TWAEFKTAMYQERVDQFGNLKQVTFKDPTKPWPRYGTKTINNVDELQKLMDEAVLQDA
                     TGTRWSNYNPETDSAVHKLKRAIFKAYLDQTNDFRSSIFENKK"
     gene            14839..15015
                     /locus_tag="VVR18_001525"
     CDS             14839..15015
                     /locus_tag="VVR18_001525"
                     /inference="COORDINATES: protein motif:HMM:TIGR01167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU6033025.1"
                     /translation="MQAGIPPDNEVSYALIYQQETLPATGSSTSELTALGLLAVGSLV
                     LLVHNMTGTVFCSL"
     gene            15235..16086
                     /gene="ylqF"
                     /locus_tag="VVR18_001526"
     CDS             15235..16086
                     /gene="ylqF"
                     /locus_tag="VVR18_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HEU6033026.1"
                     /translation="MATIQWFPGHMSKARRQVQENLKFVDFVTILVDARLPLSSQNPM
                     LTKIVGDKPKLLILNKADLADPAMTKEWRQYFESQGIQTLAINSKEQVTVKVVTDAAK
                     KLMADKIARQKERGIQIETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQ
                     WLKTNKDLEILDTPGILWPKFEDETVALKLALTGAIKDQLLPMDEVTIFGINYFKEHY
                     PEKLAERFKQMKIEEEAPVIIMDMTRALGFRDDYDRFYSLFVKEVRDGKLGNYTLDTL
                     EDLDGND"
     gene            16073..16852
                     /locus_tag="VVR18_001527"
     CDS             16073..16852
                     /locus_tag="VVR18_001527"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HEU6033027.1"
                     /translation="MATIKEIKELLVTVKELESPIFLELEKDNRSGVQKEISKRKRVI
                     QAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKG
                     LNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSP
                     QPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFSGYDF
                     ATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES"
     gene            16868..18418
                     /locus_tag="VVR18_001528"
     CDS             16868..18418
                     /locus_tag="VVR18_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HEU6033028.1"
                     /translation="MEEQSEIVRSKKEFAFASSTILSQVGRGIIVGLIVGIIVGSFRF
                     LIEKGFHLIQGVYQDQGYLVRNLFVLVLFYILICWLSAKLTRSEKDIKGSGIPQVEAE
                     LKGLMSLNWWGILWKKYVLGILAIASGLMLGREGPSIQLGAVGGKGIAKWLKSSPVEE
                     RSLIASGAAAGLAAAFNAPIAALLFVVEEVYHHFSRFFWVSTLAASIVANFVSLLMFG
                     LTPVLDMPDNIPPMTLDQYWIYLVMGIFLGFSGFLYEKAVLNVGRVYDLIGQKIHLDR
                     AYYPILAFILIIPVGIFLPQIIGGGNQLVLSLTEQNFSFQVLLAYFLIRFIWSMISYG
                     SGLPGGIFLPILALGSLLGALIGAICVNLGLVSQEQFPIFVILGMSGYFGAISKAPLT
                     AMILVTEMVGDIRNLMPLGLVTLVSYIIMDLLKGTPVYEAMLEKMLPEEVSSEGEVTL
                     IEIPVSDKIAGKQVHELNLPHNVLITTQVHNGKSQTVNGSTRMYLGDMIHLVIPKSEI
                     GKVKDLLL"
BASE COUNT         5996 a         3655 c         3883 g         5018 t
ORIGIN      
        1 tagattgaaa taagatacga acagcttgat tagggaaatc aaattaattt ctagaaatat
       61 tttagcatcc acggtgtact attatagttt caatttacta tagttcaatc attctatcaa
      121 gaatattgaa tatataaagg cacgtaatat taaaacttct tctgatatcg aattagagtc
      181 cgatgttgat ggcgataaat cagacaatct acccgtcgac attaagacac tgggacaaca
      241 cattgaagtg tattccgtac ctaagaaaca atcataaaac tcaaagcctt gttaccgagg
      301 cttttttatt atatgatttt cagtggccag acttattcta tctaatacaa gtaaagctaa
      361 gtatttaaga tttagcagat gatgaagaaa agaaaggatg gcctaaatat tttaacagat
      421 ttacgaggct aatcatggta taatataggg tgatgaaaaa ttccaacgag gctgagatga
      481 aattacttta tactgatatt cgaacttctt tgacagaaat tctaacaaga gaggcagaag
      541 agctagttgc agctggcaag cgggtcttct acattgcccc caactctctt tcttttgaaa
      601 aggaacgcgc cgtgctggaa tgcttgtccc agcaggcttc tttttcgatt accgtcacgc
      661 gctttgctca aatggctcgt tatctggtct tgaatgattt accagttaaa actactcttg
      721 atgatatcgg tcttgggttg gccttttaca aatgccttgc cgaactcgat cccaaggact
      781 tgcgtgttta tggcgctatt aagcaggatc ctcaattgat ccagcagtta attgagcttt
      841 accatgagat gaccaaatct cagatgagtt ttttggactt ggagaattta acagatgagg
      901 ataagaggac ggatttactc ttgatttttg agaaagtaac agcctatctt aatcaaggtc
      961 agttagccca gggaagtcag ttgtcccatt tgattgaggc tattgagaat gacaaggtaa
     1021 gtagtgattt taatcaaatc accttggtca ttgacggctt tactcgtttt tctgctgagg
     1081 aagagcgggt tgtggactta cttcacggca aaggtgttga gattgttatc ggggcttatg
     1141 ctagtaagaa agcctatacc agtcctttta gcgagggcaa tctttaccaa gccagcgtaa
     1201 aatttctcca tcatctggct tctaaatacc aaacgcctgc tcaggactgt tctcaaactc
     1261 atgagaagat ggatagtttt gacaaggcct ctcgtttgtt ggagtcttct tatgactttt
     1321 cagaactcgc tttggatgtc gatgagaaag accgtgaaaa tttacaaatc tggtcttgtt
     1381 tgacgcaaaa ggaggagttg gagctagtag cccgtagcat tcgtcagaaa ttacatgaga
     1441 actcagacct gagctacaag cattttcgta ttctcttggg ggatgtagct tcttaccagt
     1501 tatctctcaa aaccattttt gaccagtatc agattccttt ttatcttggt agaagcgaag
     1561 ccatggctca tcatcccttg actcagtttg tcgagtctat tttagcttta aaacgttacc
     1621 gttttcgtca ggaggatttg attaatcttc ttagaactga tttgtatact gacctcagtc
     1681 agtctgatat tgatgctttt gagcaatata tccgctatct tggtatcaat ggcttgccag
     1741 cctttcagca aaccttcacc aaatcccacc atggaaaatt taatcttgag cgtttgaatg
     1801 tcctccgcct gagaatttta gcacctcttg aaaccctctt tgccagccga aaacaaaagg
     1861 ctgaaaacct cctacaaaaa tggagtgtct ttctaaaaga aggagctgtg accaagcagt
     1921 tacaagattt gacaaccact ttggaagctg tagaacagga aagacaagcc gaagtttgga
     1981 aggctttctg ccatgtttta gaacaatttg cgactgtttt tgctggttca caggttagtc
     2041 tggaagactt cctagccttg ctccattctg gaatgagttt gtcccaatac cgtaccattc
     2101 cagcaacagt ggacactgtt ctggtgcaga gttacgattt gattgcacca ttgactgctg
     2161 actttgtcta tgctattgga ctaactcagg acaatttacc aaaaatttct caaaacacca
     2221 gtcttctgac agatgaagaa aggcaaaacc taaaccaagc gaccgaagaa ggcgttcaat
     2281 tactgattgc cagcagtgaa aatctcaaga aaaatcgcta cactatgctt tccttggtca
     2341 attctgctcg taagcagttg ttcttgtcgg ctccaagcct ttttaacgaa agtgaaagta
     2401 aggaatctgc ctatcttcaa gagttgatcc attttggatt taggcggaga gagaagagga
     2461 tgaatcacaa aggactgtct aaggaggata tggggtccta tcacagtctt ttgtctagtc
     2521 tggttgccta tcaccagcag ggtgagatga gcgatactga gcaagatttg acttttgtca
     2581 aggttctgtc gcgtgtcata ggtaaaaaac tagatcagca aggtctggaa aatccagcta
     2641 tcccaaccag tccaagcagc aagaccttag ccaaggacac cttgcaagct ctctatcctg
     2701 ccaaacagga gttttacctg tctacgtcgg gtttgacaga gttttatcgc aatgaataca
     2761 gttatttcct acgctacgtt ttaggcttgc aggaggaatt acgtttgcgt cctgatgccc
     2821 gtagtcacgg gaatttcttg catcgtatct ttgaacgcgc cttgcagttg cctaatgaag
     2881 attcctttga ccaacgtcta gaacaagcta ttcaagaaac cagtcaagaa cgcgaatttg
     2941 aagctattta tcaagaaagt ttggaagccc agtttaccaa ggaagttttg cttgatgttg
     3001 cacggacaac tggacatatt ctccgacaca atccagccat cgaaacaatc aaagaagaag
     3061 caaattttgg tggaaaagac caagccttta ttcaattaga caatggacgc agtgtctttg
     3121 tacgaggcaa ggtggaccgg attgaccgtt tgaaagctaa tggagcgata ggagtagtag
     3181 actacaaatc cagtctgact cagttccagt ttcctcattt ctttaatggg ctcaattctc
     3241 agttaccaac ctatcttgct gccctaaaaa gagaagggga gcagaacttt ttcggcgcca
     3301 tgtatttgga aatggctgaa cctgtccaat ctctgatggc ggtaaaaagt ctggcaggag
     3361 cagtggtaga agccagcaaa tctatgaaat accaagggct cttcttggaa aaagaaagca
     3421 gttatttagg cgaattttat aacaaaaaca aggcgaatca actgacagat gaggaatttc
     3481 agctcctact ggactacaat gcctatcttt acaagaaagc tgctgagaag attttagcag
     3541 gccggttcgc catcaatcct tatactgaaa atggcagaag cattgcccca tacgtccagc
     3601 aacatcaggc tattacaggc tttgaagcca attaccatct gggccaagcc cgtttcctaa
     3661 aaaagttgga cctagctgat agcaagcgtc tggtcggaga aaaactcaag caagcttggc
     3721 ttgaaaaaat aagagaggag ttgaatcgat gaagcttatt ccctttttaa gtgaggagga
     3781 gattcaaaaa ctgcaagaag cagaagcaaa ttcgagcaag gaacagaaga aaactgccga
     3841 gcaaatcgaa gctatctaca cttctggcca gaatatcctg gtctcagcat cggctggttc
     3901 tggaaagacc tttgtcatgg cagagcgcat tctggaccaa ttggcgcgtg gtgtcgaaat
     3961 ttctcaactc tttatctcaa cctttaccgt caaggctgca actgaactta aagaacgttt
     4021 agagaaaaaa atcagcaaga aaatccaaga aacagatgat gtcgagctca aacaacactt
     4081 gggtcgccag ttggcagacc tacccaacgc tgccatcgga accatggact ctttcacaca
     4141 aaaattcctt ggcaaacatg gttatctgct tgatattgca cctaatttcc gtattttaca
     4201 aaaccaaagc gagcaacttc ttctcgaaaa cgaagtcttt catgaggtct ttgaagcgca
     4261 ttaccaaggt aaacagaaag agacctttag tcatttgctg aaaaactttg ctgggcgtgg
     4321 caaggacgaa cggggtctgc gccagcaggt ctataaaatc tatgacttcc tccaatccac
     4381 cagcaatcct caaaagtggc tgagtgaatc tttcctcaaa ggctttgaga aagctgattt
     4441 taccagtgaa aaagaaaaac tgactgagca aatcaaacaa gccctttggg atttggaaag
     4501 ctttttccgt taccatctgg ataacgatgc caaggagttt gcaaaggctg cctatttaga
     4561 aaatgttcag ttaattctgg atgaaattgg ctccctaaat caggagtccg atagtcaggc
     4621 ttatcaggca gtgcttgcgc atgttgttgc catctctaag gagaaaaacg gtcgagctct
     4681 gactaatgcc agccgtaagg ctgatttgaa gcccctggct gatgcctaca acgaagagag
     4741 aaagacccag tttgctaaac taggacaatt atcagaccag ataaccattc tcgactatca
     4801 agaacgttat catggagaca cttggaaact agctaaaacc ttccaatctt tcatgagcga
     4861 ttttgtggag gcttatcgtc agagaaaacg acaggaaaat gcctttgaat tcgctgatat
     4921 cagccattac accattgaga ttttagagaa tttcccacaa gttcgtgagt cttatcagga
     4981 gcgcttccat gaagtcatgg tcgatgagta tcaggatacc aaccatattc aagaacggat
     5041 gctggaattg ttgtctaatg gccacaatcg ctttatggtg ggagatatca agcaatccat
     5101 ctatcgtttc cgtcaggcag acccgcagat tttcaatgag aaattccaac gctatgcgca
     5161 aaatccccaa gaaggtaagc tcattctcct caaggaaaat ttccgtagta gttcagaagt
     5221 gctgtcagca accaatgatg tctttgaacg tctcatggac caagaggtcg gcgaaatcaa
     5281 ctatgataac atgcaccagc ttgtttttgc caataccaaa ctgactccca atccagacaa
     5341 caaggccgaa tttctcctct acgacaagga cgatacaggt gaggaagaag agagtcaaac
     5401 agaaacgaaa ctaacaggcg aaatgcgctt agttatcaag gagatcctta aacttcatca
     5461 ggaaaaaggt gttgccttta aggaaattgc ccttctgacc tctagtcgta gtcgtaatga
     5521 ccaaattcta cttgccctgt ctgagtacgg gattcctgtc aaaactgacg gagagcaaaa
     5581 caattatctc caatccctag aagtgcaagt catgctagac actcttcgtg tcattcacaa
     5641 tcccctgcaa gactacgcct tggttgccct tatgaagtct ccaatgtttg gttttgatga
     5701 ggatgagcta gcacgtttgt cccttcagaa agcagaggat aaagtccacg aaaatctcta
     5761 tgagaaactg gtcaatgcac aaaaaatggc aagtagtcaa aaaggcttga ttcacacagc
     5821 tctagctgaa aaactaaagc aattcatgga tatcctagct tcttggcgct tgtatgccaa
     5881 aacccattct ctctatgact tgatttggaa gatttacaac gaccgttttt attatgacta
     5941 tgttggggct ttgccgaatg gtcctgctag gcaggccaat ctctatgccc tagcactgcg
     6001 tgctgatcaa tttgaaaaga gcaatttcaa aggtttgtcg cgttttattc gtatgattga
     6061 ccaagtctta gaagcccagc acgatttggc aagcgtggcc gtcgcaccgc caaaagatgc
     6121 agtagagctc atgaccatcc acaagagtaa agggctggag tttccttacg tctttatcct
     6181 caatatggat caagatttca acaagcaaga ctctatgtca gaagtcattc tcagtcgtca
     6241 gaatggtctt ggtgtcaaat atattgctaa gatggagaca ggggcagtag aagaccacta
     6301 tcctaaaacc atcaaactct ccattcctag tctgagctat aggcagaacg aagaggaatt
     6361 acagctagca agctattctg agcagatgcg tttgctgtat gttgctatga cgcgggctga
     6421 gaaaaagctc tatcttgtcg gcaagggttc tcgtgaaaag ctggaagcca agcaataccc
     6481 agcagcccaa aatgggaaac taaatagcaa tactagactg caagcacgga atttccaaga
     6541 ttggctttgg gctatcagta aagtgtttac taaggacaag ctcaacttta gttatcgttt
     6601 tattggcgaa gatcagttga ccagagaagt tatcggagag ttggaaacca agagtcctct
     6661 ccaagatagc tcccaagcag acaatcgtca gtcagatacc atcaaagaag ctctggaaat
     6721 gctgaaggag gtggcagttt ataatactct tcaccgcgca gctattgaac ttcctagtgt
     6781 tcaaacccca agtcaaatca agaaattcta cgaaccagtt atggatatgg aaggtgtcga
     6841 gattgctggt caaggtcagt cagtaggcaa gaaaatcagc ttcgatttgc cagatttttc
     6901 aaccaaagaa aaggtaactg gagctgagat tggtagtgct actcacgaac tcatgcagag
     6961 aattgacctc agccagcaac taacccttgc tagcctaaca gaaacactca aacaagttca
     7021 aactagccaa gctgtcagag acaagatcaa tcttgataaa attcttgctt tctttgacac
     7081 agtactcggt caggaaattc ttgctaatac cgaccatctc tatcgcgagc aacctttctc
     7141 catgctcaaa cgagaccaaa agagtcagga agactttgtt gtccgtggta tccttgatgg
     7201 ctatctgctt tacgaaaaca aaattgttct gttcgactac aagacagacc gctatgatga
     7261 accaagtcaa ctcgtagacc gctatcgtgg tcagttagct ctatacgaag aggctttatc
     7321 acgagcctat tcgattgaaa atattgaaaa atacttgatt ttactcggta aagacgaggt
     7381 tcaagttgta aaagtataac ttatactctt tgaaaatctc ttcaaaccac gtcagcttcg
     7441 ccttgctgta tatatggtta ctgacttcgt cagttctatc cacaacctca aaacagtgtt
     7501 ttgagctgac tgcggctagc tttctagttt gctctttgat ttttattgag tattagaaag
     7561 gagacctcat gacacttcca gttagaaaat ccctgcacga tgcagtttta caggcttcga
     7621 aagcggatac ttgggaacaa gctaccaagg aatggaatga agtttccttg atttttaacg
     7681 gtatcggccg tagcaattgt gtctgtggaa atgccatcaa atacgcttat gaactcttta
     7741 acggtgtcac aggccaacgc ctctttccaa ttggtagcga ctgtgttcgt cattttcatc
     7801 gattgtccct tgaccagcaa ttggaagagg aagaaaaact gctcagaaag gttgaaaatc
     7861 taaccagaaa agctcagaaa aaggaaaaaa tcaaggtcaa taaaagtgac tttgacgagc
     7921 gacttctaaa atggctctgg gaaaaaggtg ttttcaaacc caatcgtggc aatcaatttg
     7981 cgcctgagag agactaccag cttttcctag aagtctttca gggaggaagt tggaccaagg
     8041 cggaactaaa gaaaaaggct cggatggaag aagtccttga aaagtgtatc aaaccctttt
     8101 tacttgggaa atcggatgac caactctacc ttgtcaagct aggcaaggag aaaattgact
     8161 acgaacaaga actccgtatc caggcagaga aagaacgcaa gaagagggat aaaatcgcca
     8221 agcaatatgt agacaatctg gttctagcca tgggacccgc agagcgtgct tatcaagatt
     8281 actttggctt tacagagacc ctgactcaag aagaacgcaa gtgggaaaaa attctttttg
     8341 gtaaaaatag agcagaacgg gctatcaaag ccaaacaata ccaaaaagag ctggaaaaag
     8401 accaacgaat tgccagtcag gatccaattg aaagaaaaca gaatcagact tggctcctca
     8461 attcctattt tcgtgagctt cctgaagaaa aagctcgatt ttctaggctc ttattagaat
     8521 atagaaaaag tggtgaagta cccttttcaa ctgaatacct gtcagatcat ctcatcgact
     8581 ttttctataa aatgaaagcc tttgaatttg aaatcgcacc agaacaagtc cgagattttc
     8641 taaaaaaaag cctgcaggaa gaccatcgct catcagcaca aggaagctgg atagaaggaa
     8701 ttctcctcaa ctgtctcaaa ccatttttag aacgattact gatatgagta acacctaccg
     8761 tgtaaatttc atggtaggtg ttattgtacc cccaaataat ataaaacaaa gtatgaaagc
     8821 gcatctcaat tttaagactt ttttgtaaat taagagtata attaaggtat actgcctttt
     8881 ctatagataa tagataatac actaatataa taaaggtctt tgtaacatat ataaatttta
     8941 tttcaaggag gaataatgga aaagtatttt ggtgaaaaac aagagcgttt ttcatttaga
     9001 aaattatcag taggacttgt atctgcaacg atttcaagtt tattttttat gtctgtatta
     9061 gctagttcat ctgtggatgc tcaagaaact gcgggagttc actataaata tgtggcagat
     9121 tcagagctat catcagaaga aaagaagcag cttgtctatg atattccgac atacgtggag
     9181 aatgatgatg aaacttatta tcttgtttat aagttaaatt ctcaaagtca actggcggaa
     9241 ttgccaaata ctggaagcaa gaatgagatg caagccctag ttgctggtgc tagcttagct
     9301 gctctgggaa ttttaatttt tgccgtctcc aagaaaaagg ttaagaataa aacggtatta
     9361 catttagtat tggttgcagg gataggaaat ggtgtcttag tttcagtcca tgctttagaa
     9421 aatcatcttt tgctaaatta caatactgac tataaattga cctctggaga aaaattacct
     9481 cttcctaaag acatttcagg ttacacatat attggatata tcaaagagga aaacataact
     9541 tctgagtctg aagtaagtaa tcaaaagagt tcagttgcca ctcctataaa acaacaaaag
     9601 gtggattata gtgttacacc gaattttgta gaccatccat caacagtaca agctattcag
     9661 gaacaaacac ctgtttcttc aactaagccg acagaagttc aagtagttga aaaacctttc
     9721 tctactgaat taatcaatcc aagaaaagaa gagaaacaat cttcagattc tcaagaacaa
     9781 ttagccgaac ataagaatct agaaacgaag aaagaggaga agatttctcc aaaagaaaag
     9841 actggggtaa atacattaaa tccacaggat gaagttttat caggtcaatt gaacaaacct
     9901 gaactcttat atcgtgagga aactatagag acaaaaatag attttcaaga agaaattcaa
     9961 gaaaatcctg atttagctga aggaactgta agagtaaaac aagaaggtaa attaggtaag
    10021 aaagttgaaa tcgtcagaat attctctgta aacaaggaag aagtttcgcg agaaattgtt
    10081 tcaacttcaa cgactgcgcc tattccaaga atagtcgaaa aaggtactaa aaaaactcaa
    10141 gttataaagg aacaacctga gactggtgta gaacataagg acgtacaatc tggagctatt
    10201 gttgaacctg cacttcagcc tgagttgccc gaagctgtag taagtgataa aggcgtacca
    10261 gaagttcaac cagcgttacc ggaagcagtc gtaaccgaca aaggtgagcc cgcaattcag
    10321 cctgaattac ccgaagctgt tgtaaccgac aaaggtgagc ccgctgtcca acctgaatta
    10381 cccgaagctg tagtaagtga taaaggtgaa ccagagcagg tagcaccatt gccagaatat
    10441 aaggggaata ttgagcaagt aaaacctgaa actccggttg agaagaccaa agaacaaggt
    10501 ccagaaaaaa ctgaagaagt tccagtaaaa ccaacagaag aaacaccagt aaatccaaat
    10561 gaaggtacta cagaaggaac ctcaattcaa gaagcagaaa atccagttca acctgcagaa
    10621 gaatcaacaa cgaattcaga gaaagtatca ccagatacat ctagcgaaaa tactggggaa
    10681 gtgtccagta atcctagtga ttcgacaacc tcagttggag aatcaaatca accagaaaaa
    10741 aacagaactg caacaaaacc agaaaattca ggtaatacaa catcagagaa tggaccaaca
    10801 gaaccatcaa acggaaattc aactgaggat gtttcaaccg aatcaaacac atccaattca
    10861 aatggaaacg aagaaattaa acaagaaaat gaactagacc ctgataaaat ggtagaagaa
    10921 ccagagaaaa aactcgaatt aagaaatgtt tctgatattg agttgtatag tcagacgaat
    10981 ggaacctaca gacaacatgt ttcattggat ggaattccag agaatacgga tacttacttt
    11041 gtcaaggtaa aatcttcagc atttaaagat gtctatatac cagtagcttc aataactgaa
    11101 gagaaaagaa atgggcagtc agtttataaa atcacagcca aagctgagaa actccagcaa
    11161 gaactagaaa ataaatatgt cgacaatttc accttctacc tcgataagaa ggctaaagag
    11221 gaaaatacaa actttacttc ctttagcaac ctggtcaaag ctataaacca aaatccctct
    11281 ggaacctatc atttagcggc cagcctgaat gctaacgaag tggagcttgg tcctgatgaa
    11341 agatcctata tcaaggacac ctttactggt cgtttaatcg gtgaaaaaga tggcaagaat
    11401 tatgctatct ataatttgaa aaaacctctg tttgaaaact tgagtggtgc tacagtagaa
    11461 aaactgagtc taaaaaatgt tgctatttca gggaaaaatg atattggttc actggcaaat
    11521 gaagctacga atggcacaaa gattaaacaa gttcatgttg atggtgttct ggctggagaa
    11581 cgtggtgtcg gtggtttgtt ggctaaggca gaccaatcaa acatcgcaga gagcagtttc
    11641 aagggaagaa ttgtcaatac ctatgaaacg actgatgcct acaatattgg cggtctggtc
    11701 ggtcatttaa caggaaaaaa tgcgtctatt gctaaatcca aagcgacagt aaccatttcg
    11761 tcaaacacca ataggtcaga tcagactgtc ggtggtcttg caggtctagt agaccaagat
    11821 gcgcatatac agaacagtta tgcggaaggt gatattaata atgtcaagca ctttggtaaa
    11881 gtcgctggtg tggcaggata tttgtgggat cgaacttctg gtgaggaaaa acacgctggt
    11941 gaattgacca atgttcttag cgatgtcaat gtaacaaacg gaaatgccat cactggatac
    12001 cactatacag gaatgaaggt agctaataca tttagtagta aggctaatag agttttcaat
    12061 gtcactttag agaaggatga ggtcgtcagc aaggaatcct ttgaagaaag aggaacaatg
    12121 ctagatgctt ctcaaattgt aagcaaaaaa gcagaaataa atcctctcac tctaccaacg
    12181 gtggaacccc tctcaacaag tggcaagaaa gacagtgatt tttctaagat agcccattat
    12241 caagctaacc gtgctttggt ttataagaac attgaaaaat tgttaccttt ttataataag
    12301 tcaaccatcg tcaaatacgg aaacctggtt aaggagaaca gtctcttata ccaaaaagaa
    12361 ctcttatctg cagttatgat gaaggatgac caagtaatca cagatattgt ttccaacaaa
    12421 cagactgcaa acaaactctt acttcactat aatgaccatt catctgagaa atttgatctc
    12481 aagtaccaga ctgattttgc caatctagca gaatataatc taggtaatac gggacttctc
    12541 tacactccta accaattctt atatgatcga gactctattg ttaaggaagt cttgcctgag
    12601 ttgcagaagc ttgattacca gtcagatgct atcagaaaga cacttggtat ttctccagaa
    12661 gttaagttaa ccgagctcta tttagaagac cagttctcca aaacaaaaca aaatctggga
    12721 gacagcttga aaaaactttt gtcagcagat gccggtctag ctagcgataa ctcagtcacc
    12781 agaggctatc ttgtagataa aatcaagaat aataaggaag ccttgctact cggtttaact
    12841 tatttagaac gttggtataa ctttaactat ggtcaagtga atgtcaaaga cctagttatg
    12901 tatcatccag acttctttgg taaaggaaat acttccccac tagatactct gattgagtta
    12961 ggtaaatctg gctttaacaa tcttctagct aagaataatg tcgatactta tggtatcagt
    13021 cttgccagtc aacatggaac gacagatttg tttagcacgc tggaacatta ccgaaaagtc
    13081 tttttaccaa atacaagcaa taatgactgg tttaaatcag agactaaggc ttacattgtc
    13141 gaagaaaaat ccactatcga agaggtgaaa acgaagcaag ggttagctgg caccaagtat
    13201 tctatcggtg tttatgatcg tatcacgagt gccacatgga aataccgcaa tatggtcttg
    13261 cctctcctga ccttgccaga gagatccgta tttgtcatct cgaccatgtc tagtctagga
    13321 tttggagctt atgatcgcta ccgcagtagt gaccataaag cgggcaaggc tctcaatgat
    13381 tttgttgaag aaaatgcgcg tgaaacagcc aaacgtcagc gagatcacta cgattattgg
    13441 tatcgtattt tagatgaaca gtcacgcgaa aaactctatc gtacgattct cctttatgat
    13501 gcctataagt ttggggatga cacaacatca ggaaaagcta cagcggaggc taagtttgat
    13561 agctccaatc cagctatgaa gaacttcttt ggaccagttg gcaataaggt agtacacaac
    13621 cagcatggag cctacgctac aggggacggc gtctactata tgtcttaccg catgctggac
    13681 aaggatggag ccattactta tacccatgaa atgacccatg attcggatca ggatatttac
    13741 cttggtggct atggtcgaag aaatggcttg ggaccagagt tcttcgcaaa aggcttattg
    13801 caagcccctg accaaccacg tgacgcaacc attaccatta attctatctt gaaacactca
    13861 aaatcagata gtacagaggg atcccgtctt caagtcttgg atccgacaaa gagattccaa
    13921 aacgcagcag atcttcagaa ctatgtccat aacatgtttg accttatcta catgatggaa
    13981 tatctcgaag ggcagtcaat cgttaataaa ctaagtgttt accagaaaat ggcggctctc
    14041 agaaaaattg agaacaagta tgtgaaagat ccagcagatg gaaatgaggt ttatgccact
    14101 aacgtagtca aagaattgac agaagcagag gcccgaaacc tgaatagttt tgaaagtttg
    14161 attgaccaca acatcttatc agctcgtgag taccagtctg gcgactatga acgaaatggc
    14221 tactatacca tcaaactctt tgccccaatc tattcagctc tcagcagtga gaaaggcaca
    14281 ccaggggacc ttatgggacg taggattgcg tacgaacttt tggctgccaa aggctttaag
    14341 gatggtatgg taccatatat ttccaaccaa tacgaagaag atgctaaaca acaagggcaa
    14401 actatcaatc tttatggtaa agaacggggc ttggtgaccg atgagcttgt tttgaaaaag
    14461 gtatttgatg gtaagtataa aacttgggca gaatttaaga cagctatgta ccaagaacgg
    14521 gtggatcagt ttggaaactt gaagcaggtg acctttaaag atccgacaaa accatggcca
    14581 agatatggca caaagactat caataatgtg gatgaattgc agaaactaat ggatgaagct
    14641 gttttgcagg atgctacagg tacacgttgg agtaattata atccagaaac ggacagtgcc
    14701 gtccataagt tgaagagagc aatctttaaa gcctatcttg accaaacaaa tgattttaga
    14761 agttcaattt ttgagaataa aaaatagtgt ttactattag gaaataaagt ttaaaaaggt
    14821 gatgaagaac aaaccaagat tcaagcagga attcctcctg ataatgaagt aagttatgct
    14881 cttatttatc agcaggaaac tcttcctgca acaggttcat caacttctga gcttacagct
    14941 ttaggcctat tagctgttgg tagtttagtt cttttggttc ataatatgac gggaacagtt
    15001 ttttgctccc tctgaaaagt catcatttga tggctttttt ctatataggg taaaagatag
    15061 ggtaaaaggc tatcatcgga caaaataaag aaggcatgat ataatataaa gtagatttct
    15121 atgtcataaa acaagaactg tttggacatc attcatttga aaactctcta tgttcaaaca
    15181 atagtaaaat aaaatagggg tgctaaaccc ttgctacgaa aggaaaaaaa tgcaatggct
    15241 actattcaat ggtttcctgg tcacatgtct aaagcgcgtc gacaggtgca ggaaaattta
    15301 aaatttgttg attttgtgac gattttagta gatgcacgct tgcctctatc tagtcaaaat
    15361 cctatgttga ccaagattgt tggtgataaa ccaaaactct tgattttaaa caaggccgac
    15421 ttggctgatc cagcaatgac caaggaatgg cgtcagtatt ttgaatcaca aggaatccag
    15481 acgctagcta tcaactccaa agagcaagtg actgtaaaag ttgtaacaga tgcggccaag
    15541 aagctcatgg ctgataagat tgctcgccag aaagaacgtg ggattcagat tgaaaccttg
    15601 cgtaccatga ttattgggat tccaaacgct ggtaaatcaa ctctgatgaa ccgtttggct
    15661 ggtaaaaaga ttgctgttgt tggaaacaag ccaggggtca caaaaggtca acaatggctt
    15721 aaaaccaata aagatctgga aatcttggat acaccgggga ttctctggcc taagtttgag
    15781 gatgaaactg ttgcacttaa gttggcattg actggagcta tcaaggatca gttgcttcct
    15841 atggatgagg ttaccatttt tggtatcaat tatttcaaag aacattatcc agaaaagctg
    15901 gctgaacgct tcaaacaaat gaaaattgaa gaagaagcgc ctgtgattat tatggatatg
    15961 acccgcgccc tcggtttccg tgatgactat gaccgttttt acagtctctt cgtgaaggaa
    16021 gtccgtgatg gcaaactcgg taactatacc ttagatacat tggaagacct cgatggcaac
    16081 gattaaagaa atcaaagaac tccttgtgac agtcaaggag ttagaaagcc ctattttttt
    16141 agagcttgaa aaggataatc gctcaggagt tcaaaaggaa atcagcaagc gtaaaagagt
    16201 cattcaagct gaattagatg aaaatttgcg cttggaatcc atgctttctt atgaaaaaga
    16261 actttataag caaggattga ccttaattgc aggtattgat gaggttggtc gtggtcctct
    16321 tgctggtcct gtagtcgctg cggccgttat tttacctaaa aattgtaaga ttaaaggtct
    16381 caacgacagc aagaaaattc ctaaaaagaa acatctggag attttccaag ccgttcaaga
    16441 ccaagccttg tcgattggaa ttggtatcat agataatcag gtcatcgacc aagtcaacat
    16501 ctatgaagca accaaactag ccatgcaaga agcaatctcc cagctcagcc ctcaaccaga
    16561 gcaccttttg attgatgcca tgaaactgga cttgcccatt tcacaaacct ccattatcaa
    16621 aggagatgcc aactccctct ctatcgcagc agcatctata gtagccaagg taacacgtga
    16681 tgaattgatg aaagaatacg atcagcagtt ctctggctat gatttcgcta ctaatgcagg
    16741 atatggcaca gctaaacatc tggaaggcct cacaaaacta ggagttaccc caattcaccg
    16801 aaccagcttt gaacccgtta aatcactggt tttaggtaaa aaagaaagtt aattgaaagg
    16861 aaataccatg gaggaacagt cggaaatagt ccgttctaag aaagaattcg cttttgcatc
    16921 cagcactata ctatcccaag ttggtcgagg aatcattgtc ggcctcatcg ttggaattat
    16981 cgtcggatcc tttcgtttct taattgaaaa gggcttccac ctgatacaag gagtttatca
    17041 agatcaaggg tacttagtgc gcaatctttt tgtactggtt ttgttttata tactcatctg
    17101 ttggctcagt gccaaactaa cacggtcaga aaaagatatt aaaggctcag gaattcctca
    17161 agtcgaagcc gaactgaaag gcctcatgtc cctcaactgg tggggcattc tttggaaaaa
    17221 atatgtgcta ggtattcttg ctattgccag tggactcatg ctgggtcgag agggacccag
    17281 cattcaactt ggagcagttg gtggtaaagg aattgccaag tggctcaaat ccagtccagt
    17341 agaggaacgt tccttgattg ccagtggagc tgcagcaggt ttagccgcag cctttaatgc
    17401 tcctattgca gcacttctct ttgttgtaga agaagtctat caccattttt cgcgcttttt
    17461 ctgggtctca actctagcag ccagcatcgt agcaaacttt gtgtctctac tcatgttcgg
    17521 tttgacacca gtattggata tgccagataa cattcctccc atgaccctag atcagtattg
    17581 gatatatctc gtcatgggaa ttttccttgg attttcaggt tttctctatg agaaagctgt
    17641 attaaacgtt ggaagagttt atgacttgat tggtcaaaaa atccatttgg atagagctta
    17701 ttatcccatc ttggctttta tccttatcat accagtcgga atcttcttac ctcaaatcat
    17761 tggtggcgga aatcagcttg tcctttcttt aactgaacaa aattttagtt tccaagtttt
    17821 attagcttac tttttgatcc gctttatttg gagtatgatt agctatggaa gtggactgcc
    17881 aggaggaatt ttcctcccca ttttagctct tggttctttg cttggtgcct taattggtgc
    17941 tatctgtgtc aatcttggac ttgtcagtca agagcaattc cctatatttg tcattctagg
    18001 aatgagtggc tattttggag ccatatcaaa agctccctta accgctatga tcctcgtaac
    18061 tgagatggta ggagatattc gcaacctcat gccacttggt cttgtcactc ttgtttctta
    18121 tattatcatg gatttgctca aaggtacgcc agtctatgaa gccatgctgg aaaaaatgct
    18181 tccagaagaa gtatctagcg aaggagaagt tacacttatc gaaataccag tttctgataa
    18241 aattgctggg aaacaagttc atgaactcaa cttaccacac aacgtcctca tcacaactca
    18301 agtccataat ggcaagagcc aaacagttaa cggctcaacc agaatgtatc tgggtgatat
    18361 gattcacctg gttattccaa aaagtgaaat tggaaaagtc aaagatttgt tgttgtagta
    18421 tgagcattta cataatttat gttatgtaaa tgctcagctt gatttattta gaaaaccgat
    18481 tctcagaaat gagatcggtt attttttact gatgaggaat tttacatata aataattgaa
    18541 ctttattaaa aa
//
LOCUS       DAVHSO010000045        18163 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.045, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000045 DAVHSO010000000
VERSION     DAVHSO010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18163)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18163)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18163
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.045"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..129
                     /locus_tag="VVR18_001529"
     CDS             <1..129
                     /locus_tag="VVR18_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HEU6033029.1"
                     /translation="LKINEGLNIGSVRSPLTPVTEEDRPVVEAAAALIRETKERFL"
     gene            147..1031
                     /locus_tag="VVR18_001530"
     CDS             147..1031
                     /locus_tag="VVR18_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEU6033030.1"
                     /translation="MTYYVAIDIGGTNIKYGLVDQEGQLLESHEMPTEAHKGGPHILQ
                     KTKDIVASYLEKGPVAGVAISSAGMVDPDKGEIFYAGPQIPNYAGTQFKKEIEESFTI
                     PCEIENDVNCAGLAEAVSGSGKGASVTLCLTIGTGIGGCLIMDRKVFHGFSNSACEVG
                     YMHMQDGAFQDLASTTALVKYVAEAHGEDVDQWNGRRIFKEATEGNKICMEGIDRMVD
                     YLGKGLANICYVANPEVVILGGGIMGQEAILKPKIRTALKEALVPSLAEKTRLEFAHH
                     QNTAGMLGAYYHFKTKQS"
     gene            complement(1047..1898)
                     /locus_tag="VVR18_001531"
     CDS             complement(1047..1898)
                     /locus_tag="VVR18_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HEU6033031.1"
                     /translation="MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVT
                     QKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQANQVSKHSPLTKRVLRSYSNMR
                     EQTQDLIDEIQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQD
                     GFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFTSVPNKDSQTYTET
                     VLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRR
                     QKRVRKS"
     gene            2098..4155
                     /gene="pbp2b"
                     /locus_tag="VVR18_001532"
     CDS             2098..4155
                     /gene="pbp2b"
                     /locus_tag="VVR18_001532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2B"
                     /protein_id="HEU6033032.1"
                     /translation="MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNK
                     DFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETA
                     KKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNN
                     AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMP
                     GISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQ
                     YEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFN
                     SELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSV
                     VKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSN
                     TYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFV
                     PKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGD
                     LIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTA
                     ESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYH
                     PMN"
     gene            4166..4762
                     /gene="recR"
                     /locus_tag="VVR18_001533"
     CDS             4166..4762
                     /gene="recR"
                     /locus_tag="VVR18_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HEU6033033.1"
                     /translation="MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFA
                     KNLLSAKRELTYCSICGRLTDDDPCSICTDSTRDQTTILVLEDSRDVAAMENIQEYHG
                     LYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLL
                     KPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL"
     gene            4938..5981
                     /locus_tag="VVR18_001534"
     CDS             4938..5981
                     /locus_tag="VVR18_001534"
                     /EC_number="6.3.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HEU6033034.1"
                     /translation="MKQTIILLYGGRSAEREVSVLSAESVMRAVNYDRFIVKTFFISQ
                     SGDSIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSV
                     QGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEV
                     EEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVG
                     LLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKVTMDIPAKISDDVVAVMRQNAEAAFR
                     AIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWENMGISYPELIERLVDL
                     AKESFDKREAHLI"
     gene            6065..7438
                     /locus_tag="VVR18_001535"
     CDS             6065..7438
                     /locus_tag="VVR18_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HEU6033035.1"
                     /translation="MKLTIYEVAQAVGAKNDVSLFADAQLEKAEFDSRLIGTGDLFVP
                     LKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDV
                     FAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMG
                     QDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLTP
                     ADPIVEDYLPTDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNAT
                     NAMIASYVALQEGVSEEQIHQAFQGLELTRNRTEWKKAANGADILSDVYNANPTAMKL
                     ILETFSAIPANEGGKKIAVLADMKELGDQSIQLHNQIILSLSPDVLDTVIFYGEDIAE
                     LAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQILLKGSNSMNLAKLVE
                     SLENEDK"
     gene            7425..8036
                     /locus_tag="VVR18_001536"
     CDS             7425..8036
                     /locus_tag="VVR18_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU6033036.1"
                     /translation="MKTSDFVKYLQRMIAITDTGLTFTKDPFDRERYEDLRDFLSEML
                     NQASDLDSEEVAEVLKPTSAYATPLMDVRAWIVEDEKICLVRGQGEDSWALPGGFGEV
                     GYSPTENILKEIEEETGFKAKVERLLAVFDTNRFQLQSKQYTKFVFGCKLLDGQFQEN
                     QEIADLQFFAIDQLPNLSEKRITKEQIELLWQVYQGHRGQYLD"
     gene            8127..8831
                     /locus_tag="VVR18_001537"
     CDS             8127..8831
                     /locus_tag="VVR18_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001055242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02206 family membrane protein"
                     /protein_id="HEU6033037.1"
                     /translation="MNLWDIFFTTQATEPPKFDLFWYVSLFTLLALTFYTAHRYREKK
                     VYQRFFQILQTVQLILLYGWYWVNHMPLSESLPFYHCRMAMFVVLLLPGQSKYKQYFA
                     LLGTFGTLAAFVYPVPDAYPFPHITILSFIFGHLALLGNSLVYLLRQYNARLLDVKGI
                     FLMTFALNALIFVVNLVTGGDYGFLTKPPLVGDHGLVANYLLVSIVLVATISLTKKIL
                     EFFLAQEAEKMIAKEA"
     gene            9050..10423
                     /gene="ftsA"
                     /locus_tag="VVR18_001538"
     CDS             9050..10423
                     /gene="ftsA"
                     /locus_tag="VVR18_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsA"
                     /protein_id="HEU6033038.1"
                     /translation="MAREGFFTGLDIGTSSVKVLVAEQRNGELNVIGVSNAKSKGVKD
                     GIIVDIDAAATAIKSAISQAEEKAGISIKSVNVGLPGNLLQVEPTQGMIPVTSDTKEI
                     TDQDVENVVKSALTKSMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVRLEMRGLLYT
                     GPRTILHNLRKTVERAGVQVENVIISPLAMVQSVLNEGEREFGATVIDMGAGQTTVAT
                     IRNQELQFTHILQEGGDYVTKDISKVLKTSRKLAEGLKLNYGEAYPPLASKETFQVEV
                     IGEVEAVEVTEAYLSEIISARIKHILEQIKQELDRRRLLDLPGGIVLIGGNAILPGMV
                     ELAQEVFGVRVKLYVPNQVGIRNPAFAHVISLSEFAGQLTEVNLLAQGAIKGENDLSH
                     QPISFGGMLQKTAQFVQSTPVQPAPAPEVEPVAPTEPMADFQQASQNKPKLADRFRGL
                     IGSMFDE"
     gene            10440..11699
                     /gene="ftsZ"
                     /locus_tag="VVR18_001539"
     CDS             10440..11699
                     /gene="ftsZ"
                     /locus_tag="VVR18_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000144288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HEU6033039.1"
                     /translation="MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAA
                     NTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFI
                     TAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVD
                     TLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTV
                     MANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEA
                     EEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARTATN
                     YRETVKPAHSHGFDRHFDMAETVELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSV
                     VSPVERFEAPISQDEDELDTPPFFKNR"
     gene            11704..12375
                     /locus_tag="VVR18_001540"
     CDS             11704..12375
                     /locus_tag="VVR18_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HEU6033040.1"
                     /translation="MNVKENTELVFREVAEASLSANRESGSVSVIAVTKYVDVPTAEA
                     LLPLGVHHIGENRVDKFLEKYEALKDRDVTWHLIGTLQRRKVKDVIQYVDYFHALDSV
                     KLAGEIQKRSDRVIKCFLQVNISKEESKHGFSREELLEILPELARLDKIEYVGLMTMA
                     PFEASSEQLKEIFKATQDLQREIQEKQIPNMPMTELSMGMSRDYKEAIQFGSTFVRIG
                     TSFFK"
     gene            12385..12924
                     /locus_tag="VVR18_001541"
     CDS             12385..12924
                     /locus_tag="VVR18_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HEU6033041.1"
                     /translation="MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTPVNSSQEPALP
                     MNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAG
                     NESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRL
                     PDEDQQGEFGFDMKRNRVR"
     gene            12924..13187
                     /locus_tag="VVR18_001542"
     CDS             12924..13187
                     /locus_tag="VVR18_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HEU6033042.1"
                     /translation="MIFLIRMIYNAVDIYSLILVAFAVMSWFPGAYESSLGRWIVALV
                     KPVLAPLQRLPLQIAGLDLSVWVAIVLVRFLGENLVRFLAMIG"
     gene            13184..13969
                     /locus_tag="VVR18_001543"
     CDS             13184..13969
                     /locus_tag="VVR18_001543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HEU6033043.1"
                     /translation="MNKGIYQHFSIEDRPFLDKGMEWIKKVEDSYAPFLTPFINPHQE
                     KLLKILAKTYGLACSSSGEFVSSEYVRVLLYPDYFQPEFSDFEISLQEIVYSNKFEYL
                     THAKILGTVINQLGIERKLFGDILVDEERAQIMINQQFLLLFQDGLKKIGRIPVSLEE
                     RPFTEKIDKLEQYRELDLSVSSFRLDVLLSNVLKLSRNQANQLIEKKLVQVNYHVVDK
                     SDYTVQVGDLISVRKFGRLRLLQDKGQTKKEKKKITVQLLLSK"
     gene            13978..14766
                     /gene="divIVA"
                     /locus_tag="VVR18_001544"
     CDS             13978..14766
                     /gene="divIVA"
                     /locus_tag="VVR18_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIVA"
                     /protein_id="HEU6033044.1"
                     /translation="MPITSLEIKDKTFGTRFRGFDPEEVDEFLDIVVRDYEDLVRANH
                     DKNLRIKSLEERLSYFDEIKDSLSQSVLIAQDTAERVKQAAHERSNNIIHQAEQDAQR
                     LLEEAKYKANEILRQATDNAKKVAVETEELKNKSRVFHQRLKSTIESQLAIVESSDWE
                     DILRPTATYLQTSDEAFKEVVSEVLGEPIPAPIEEEPIDMTRQFSQAEMEELQARIEV
                     ADKELSEFEAQIKQEVETPTPVVSPQVEEEPLLVQLAQCMKNQK"
     gene            15114..17906
                     /locus_tag="VVR18_001545"
     CDS             15114..17906
                     /locus_tag="VVR18_001545"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000768038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HEU6033045.1"
                     /translation="MKLKDTLNLGKTAFPMRAGLPTKEPVWQKEWEDAKLYQRRQELN
                     EGKPHFVLHDGPPYANGNIHVGHAMNHISKDIIIRSKSMSGFNAPYIPGWDTHGLPIE
                     QVLAKQGVKRKEMDLVEYLKLCREYALSQVYKQRDDFKRLGMSGDWENLYVTLTPDYE
                     AAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGK
                     GILDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPAGETRKFVVAAELLTSLSEK
                     FGWADVQVLATYRGQELNHIVTEHPWDTAVDELVILGDHVTTDSGTGIVHTAPGFGED
                     DYNVGIANGLEVAVTVDERGIMMANAGPEFEGQFYDKVVPTVIEKLGNLLLAQEEISH
                     SYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDAIDKVKFHTEWGKVRLYNMIRDRGD
                     WVISRQRAWGVPLPIFYAEDGTAIMTAETIEHVAQLFEVHGSSIWWERDAKDLLPEGF
                     THPGSPNGEFKKETDIMDVWFDSGSSWNGVLVNRPNLTYPADLYLEGSDQYRGWFNSS
                     LITSVANHGVAPYKQILSQGFALDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTS
                     VDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDTVAYDELRSVDKYMT
                     IRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQ
                     MQTVFYDILVKITKLLTPILPHTAEEIWSYLEFETEDFVQLSELPEAQTFANQEEILD
                     TWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYQNEVVKTLLEAVNSNVAQLLIV
                     SELTIVEGPAPEAALSFEDVAFTVERATGEVCDRCRRIDPTTAERSYQAVICDHCASI
                     VEENFAEAVAEGFEEK"
BASE COUNT         5416 a         3342 c         4153 g         5252 t
ORIGIN      
        1 ttgaaaatca atgaaggctt gaatattgga tctgttcgtt caccattgac accagtaact
       61 gaagaagatc gtccagttgt agaagcggct gcagccttga ttcgtgaaac caaggagcgc
      121 ttcctctaat ctaaaaggag gtatttatga catactacgt tgcaattgat atcggtggaa
      181 ctaacatcaa gtatggtttg gttgatcaag aggggcaact tcttgaatcg catgaaatgc
      241 caactgaggc gcataagggt ggacctcata tcttacaaaa gaccaaagat atcgtagcta
      301 gttatttaga aaaaggccca gtagcaggtg ttgccatatc ttctgctggg atggtggatc
      361 cggataaggg tgagattttc tatgctgggc cgcaaatccc taactacgca ggcacccagt
      421 tcaaaaagga aatcgaagaa agctttacta ttccttgtga gattgaaaat gatgtcaact
      481 gtgcaggtct tgctgaggca gtatctggtt caggcaaggg agcaagtgtg acactttgct
      541 tgaccattgg aacaggtatc ggtggttgct tgattatgga taggaaagtc ttccatggtt
      601 ttagtaattc agcctgtgaa gtcgggtata tgcatatgca ggatggagct tttcaagact
      661 tggcttctac aacagcttta gtgaaatatg tagctgaagc ccatggagaa gatgttgatc
      721 agtggaatgg ccgacgtatc tttaaggaag ctactgaagg aaacaaaatc tgcatggaag
      781 gtattgaccg tatggttgac tatctaggaa aaggtctggc aaatatttgc tacgttgcca
      841 atccagaagt ggttattctt ggtggtggta tcatggggca agaggctatc ctcaaaccta
      901 agatccgcac agccttgaaa gaggctttgg taccaagttt agcagaaaaa acacgattag
      961 aatttgccca tcaccaaaat acagcaggga tgttgggtgc atattatcat tttaagacaa
     1021 aacaatccta gtttggctca gccaaactag gattttctta cacgtttttg tctacgatag
     1081 ccgttgagtt ttttattttc ccagtagcta ttaaagattt tttccttgct ttcgcgattg
     1141 atttccaaaa agtaggcata aatcaaatcg ataaagaaga gcataggaag ttgagcggat
     1201 attcgttgga tataggaggg ttggctgtgg gtggctacaa gaacagtctc tgtataggtc
     1261 tggctatctt tattgggaac acttgtaaag agtacagtct ttgcccccat ctccttggca
     1321 tctaatagac tatctaaaat agaaggagtt gagcctgaaa gtgagaagcc cagtactaga
     1381 caattttcat ccatgatgct ggttgtccag gcaaagccgt cttggtctgt caaagcttcg
     1441 cagaccacac ctagtcgcat aaaacgtaat ttcatttcac gggcgacgag gccagaactc
     1501 cctgttccga agaagtagat acgctcagca tcttcgatta gctgggcaat tcgttctagt
     1561 tggatttcgt caatcaagtc ttgtgtttgt tccctcatgt tgctataact tctgaggact
     1621 cgtttggtca gtggactgtg cttggagact tggttggctt gattttctgc ctgatgttgg
     1681 tattggaaaa taaattctcg gtagccagta aagccacact ttttagcaaa gcgggtcaaa
     1741 gcagcttgag aaatatgtaa tttttgggtg acttgttgag aagataaatc atctgtaatc
     1801 gtttcagctt gcaaaaaata gcgagcgatt tcttgttcta ggtctgtcat ttcttcaaaa
     1861 tgtgaatcaa tgatagttgc gatatctggt ttgtccatag ggaaagctcc tttacatgag
     1921 tcatactgga agactagatc agggaatagt cacacttcat tataacacat aatataagga
     1981 tagataaata aaaacgcatc tctgttttaa aaacgaaaaa atcgaaaaag cttctttctt
     2041 ttccataatt ttctactcaa attgtggtac aattaagagt aagattttaa gttagaaatg
     2101 agactgattt gtatgagaaa atttaacagc cattcgattc cgattcggct taatttattg
     2161 ttttcaatcg tcattttact ctttatgacc attattggtc gtttgttgta tatgcaggtt
     2221 ttgaacaagg atttttacga aaaaaagcta gcctcagcta gtcagaccaa gattacaagc
     2281 agttcagccc gtggggaaat ttatgatgct agtggaaaac ctttggtaga aaatacgtta
     2341 aagcaggttg tttcctttac gcgtagcaat aaaatgacgg ctacagactt aaaagaaaca
     2401 gctaaaaagt tactgactta tgtgagcatc agttctccaa atttgacaga acgccagctg
     2461 gcggattact atttggctga tcctgaaatc tataaaaaaa cagtggaagc tctcccaagc
     2521 gagaaacgct tggattcaga tggcaatcgt ctatccgaat cagaactgta taacaatgcg
     2581 gtcgatagtg tacaaacgag tcaactaaac tatacagagg atgaaaagaa agaaatctat
     2641 ctttttagtc agttaaatgc tgttggaaac tttgcgacag gaaccattgc gacagatcct
     2701 ctaaatgatt ctcaggtggc tgttattgcc tctatttcaa aggagatgcc tggcattagt
     2761 atttctactt cttgggatag aaaggttttg gaaacttccc tttcttctat agttgggagt
     2821 gtatccagtg aaaaagctgg tctcccagcg gaagaagcag aagcctatct taaaaaaggc
     2881 tattctctaa atgatcgtgt aggaacctcc tatttggaaa agcaatatga agagacctta
     2941 caaggaaaac gctcggtaaa agaaatccat ctggataaat atggcaatat ggaaagcgtg
     3001 gatacaattg aggaaggtag taagggaaac aatatcaaac tgaccattga tttggctttc
     3061 caagatagcg tggatgcttt actgaaaagt tatttcaatt ctgagctaga aaatggtgga
     3121 gccaagtatt ctgaaggtgt ctatgcagtc gcccttaacc caaaaacagg tgcggttttg
     3181 tctatgtcag ggattaaaca tgacttgaaa acgggagagt tgacgcctga ttccttggga
     3241 acggtaacca atgtctttgt tccaggttcg gttgtcaagg cggcgaccat cagctcaggt
     3301 tgggaaaatg gagtcttgtc aggaaaccag accttgacag accagtccat tgtcttccaa
     3361 ggttcagctc ccatcaattc ttggtatact caggcttacg gttcattccc tatcacagcg
     3421 gtccaagctc tggagtattc atcaaatacc tatatggtcc aaacagcctt aggtcttatg
     3481 gggcaaacct atcaacccaa tatgtttgtc ggcaccagca atctagagtc tgctatggag
     3541 aaactgcgtt caacctttgg cgaatatggc ttgggtactg cgacaggaat tgacctacca
     3601 gatgaatcta ctggatttgt tcccaaagag tatagctttg ctaattacat tactaatgcc
     3661 tttgggcagt ttgataacta tacgccgatg cagttggctc agtatgtagc aactattgca
     3721 aataatggtg ttcgtgtggc tcctcgtatt gttgaaggca tttatggtaa taatgataag
     3781 ggaggactgg gtgacttgat tcagcaactg caaccgacag agatgaataa ggtcaatata
     3841 tccgactccg atatgagcat cttgcaccaa ggtttttatc aggttgccca tggtactagt
     3901 ggattgacaa ctggacgtgc cttttcaaat ggtgccttgg tatccattag cggaaaaaca
     3961 ggtacagccg aaagctatgt ggcagatggt cagcaagcaa ccaataccaa tgcggtggcc
     4021 tatgccccat ctgataatcc ccaaatcgct gtcgcagtgg tctttcctca taataccaat
     4081 ctaacaaatg gtgtaggacc ttccattgcg cgtgacatta tcaatctgta tcaaaaatac
     4141 catccaatga actagaaagg aaattatgct ttatccaaca cctattgcca agttgattga
     4201 cagttattct aagttaccag gtatcgggat taagacggct acgcgtctgg ccttttatac
     4261 gattgggatg tctgctgatg atgtcaatga atttgcaaaa aatctccttt ctgctaagag
     4321 agaattgaca tattgttcta tttgtggacg tttgacagac gacgatcctt gttctatctg
     4381 tactgattcg actcgtgacc agacaacaat tttagttctt gaggatagta gagatgtggc
     4441 agccatggaa aatatccaag aataccatgg actctatcat gtcctgcatg gcctcatttc
     4501 tcctatgaat ggtatcagtc cggacgatat caatcttaag agccttatga ctcgtcttat
     4561 ggatagtgag gtttcagaag tgattgtggc gactaatgct acagcggatg gtgaagcgac
     4621 ctccatgtat ctttcacgtt tgctcaagcc ggctggtatc aaggttacgc gtctagcacg
     4681 aggtctcgct gtgggagcgg acattgagta tgcggacgaa gtgacactct tacgagcgat
     4741 tgaaaatcgg acagagttgt aagtgtaggc aaatttacga actccattca tttataaaaa
     4801 atcaaagagg ctgaaaatcg ttcctatcgg cctctttttg tatagtgtga tgagtaggat
     4861 caggttcaag ttttaaaaaa ccaagcaaat atgatatact aaagagcgag tattctagta
     4921 gaattaggac aaataatatg aaacaaacga ttattctttt atatggtgga cggagtgcgg
     4981 aacgcgaagt ctctgtcctt tcagctgaga gtgtcatgcg tgcggtcaat tacgaccgtt
     5041 tcatagtcaa gactttcttt atcagtcagt caggtgactc tatcaaaacg caggaattta
     5101 gtcatgctcc ggggcaagaa gaccgtctca tgaccaatga aaccattgat tgggataaga
     5161 aagttgcacc aagtgctatc tacgaagaag gtgcagtggt ctttccagtc cttcacgggc
     5221 caatgggaga agatggctct gttcaaggat tcttggaagt tttgaaaatg ccttacgttg
     5281 gttgcaacat tttgtcatca agtcttgcca tggataaaat cacgactaag cgtgttctgg
     5341 aatctgctgg tattgcccaa gttccttatg tggctatcgt tgaaggcgat gatgtgactg
     5401 ctaaaatagc tgaagtggaa gaaaaattgg cttatccagt cttcactaag ccgtcaaaca
     5461 tggggtctag tgtcggtatt tctaagtctg aaaaccaaga agaactccgt caagccttaa
     5521 aacttgcctt ccgatatgac agccgtgtct tggttgagca aggagtgaat gcccgtgaaa
     5581 ttgaggttgg cctcttgggt aactacgatg tcaagagcac gctacctgga gaagttgtca
     5641 aggacgttgc cttttatgac tacgatgcca agtatattga taacaaggtt actatggata
     5701 ttcctgccaa aatcagtgat gatgtggtgg ctgtcatgcg tcaaaatgca gaagcagcct
     5761 tccgtgccat tggtggcctt ggtctatctc gttgcgattt cttctataca gataagggag
     5821 agatttttct caacgagctc aataccatgc caggtttcac ccagtggtct atgtacccac
     5881 tactttggga aaatatgggg atcagctacc cagaactaat cgagcgtttg gttgaccttg
     5941 ccaaggaaag ttttgacaag cgcgaagcgc atttgatata aaatgaaaga gagggtagaa
     6001 gccagaacca tcactgcaag gtgactagag ttctcggact tcgccccttt ttaaaggagt
     6061 agaaatgaaa ttaacaatct atgaagttgc ccaagctgtt ggagctaaaa atgatgttag
     6121 tctttttgcg gacgcccagt tagaaaaggc tgagtttgac agtcgattga ttgggactgg
     6181 agatttattt gtgccactta aaggtgcgcg tgatggccat gactttattg aaacagcctt
     6241 tgaaaatggt gcagcagtaa ccttgtctga gaaagaggtc tcaaatcatc cttacattct
     6301 agtagatgat gttttgacag cctttcaatc cttagcatcc tactatcttg aaaaaacgac
     6361 tgttgatgtc tttgctgtta caggttcaaa tggcaagaca acgactaagg atatgttggc
     6421 gcatttactg tcaacaagat acaagaccta caaaacacaa ggcaattaca ataatgagat
     6481 tggccttcct tacacagttc ttcatatgcc tgaaggaaca gaaaagttgg ttttggagat
     6541 gggacaggat cacttgggag atattcatct cttgtctgaa ttggctcgtc caaaaacagc
     6601 catcgtgacc ttggttggag aagctcattt ggcctttttc aaagatcgtt ctgagattgc
     6661 taaaggaaaa atgcaaattg cagacggaat ggcttcaggt tccttgcttt taacgccggc
     6721 tgaccctatc gtagaggact atttgccaac tgataaaaag gtggtccgtt ttgggcaagg
     6781 ggcagagttg gaaatcacag acttggttga gcgtaaggac agtctgacct ttaaggctaa
     6841 tttcttggaa caagcccttg atttgccagt gactggtaag tacaatgcta ccaatgctat
     6901 gattgcgtcc tatgttgccc tacaagaagg agtttcagag gagcaaattc atcaggcctt
     6961 ccaaggtctt gaattgacgc gtaatcgtac tgagtggaag aaagcagcca atggagcaga
     7021 tatcctgtca gacgtatata atgccaatcc aactgctatg aagctgattt tagagacttt
     7081 ctctgccatt ccagccaatg aaggtggcaa gaaaattgca gtgttggcgg atatgaagga
     7141 gcttggtgac cagtctattc aactccataa ccagataatt ttgagccttt ctccagatgt
     7201 gcttgatacc gttattttct atggagaaga cattgctgaa ttagcccaac ttgctagtca
     7261 aatgttccca atcggacacg tttattactt caagaaaaca gaagaccaag accaatttga
     7321 agacctagtt aagcaggtca aagaaagcct tggggctcat gaccaaatcc tgctcaaagg
     7381 ctctaactct atgaatctag ccaagttggt agaaagttta gaaaatgaag acaagtgatt
     7441 ttgtcaagta tttgcaaaga atgattgcca ttacagatac tggcttaacc tttacaaaag
     7501 atccgtttga ccgtgagcgc tacgaagact tgcgagactt tttatctgaa atgttgaatc
     7561 aagcatcaga ccttgattcc gaagaagtgg cagaagtctt gaagccaact tctgcttatg
     7621 cgactccgtt aatggacgtc cgtgcttgga ttgttgagga cgaaaagatt tgtctggtta
     7681 ggggacaagg agaggatagt tgggctttgc caggtggctt tggtgaggtt ggctattctc
     7741 caacagaaaa tattctcaag gaaattgaag aagaaaccgg ttttaaagcc aaagttgaaa
     7801 gactgctagc tgtttttgat accaatcgtt tccaactaca gagcaaacag tatacaaagt
     7861 ttgtttttgg atgtaagctt ctcgatggac aattccaaga aaatcaagaa attgctgacc
     7921 ttcaattttt tgccattgac caactgccga acttatctga aaaacgcatt accaaggagc
     7981 aaatagagct tctttggcag gtttatcaag gtcatagggg gcaatatctt gactaagaag
     8041 atgattatcg tatttctaaa tccatttttg acaactagca tggtataata atatgcagga
     8101 aaattttgaa ttatgaggaa gactagatga atttatggga tattttcttt acgactcagg
     8161 caaccgagcc gcccaaattt gacctttttt ggtatgttag cctatttacg ctcttagcct
     8221 taacctttta tacagcccat cgctatcgtg aaaagaaggt ttaccaacga tttttccaaa
     8281 tcttgcagac tgttcagtta atccttcttt atggttggta ctgggtcaat catatgccac
     8341 tgtcagaaag cctacccttt taccattgcc gtatggctat gtttgtggta ctcttgcttc
     8401 ctggtcaatc caaatataaa caatactttg cattattggg aacatttggg acattagcag
     8461 cctttgttta tccagtgcca gatgcttacc cttttccaca tatcaccatt ctatccttta
     8521 tctttggtca tttagcactc ttggggaact ctctagttta tctattgaga cagtataatg
     8581 cgcgattgct ggatgtgaag ggaatttttc tcatgacctt tgccctaaat gccttgattt
     8641 ttgtggtcaa tttggtgaca ggtggcgatt acggattttt gacaaaaccg ccattggttg
     8701 gggatcacgg tctagtagct aattatttac ttgtttcaat tgtgctggta gctactatca
     8761 gtttgactaa gaaaatctta gaattctttt tagctcaaga agcagaaaaa atgattgcaa
     8821 aggaagctta acacagagct ttcttttttg ctcttagaga gtttttacaa gcagcttata
     8881 aaataagaat ttctgaatag acaaactcaa aaaatggctg ggaaatttag gaaaaaagca
     8941 agcacgatta aattttttgt gttataatat tttgtgaata gctatgccta tgtttagcta
     9001 tggaataata cgaagtgcga aacttggaag atagagagga agcgatgtaa tggctagaga
     9061 aggctttttt acaggtctag atattggaac aagctctgtc aaggtgcttg tggccgagca
     9121 gagaaatggt gaattaaatg taattggcgt gagtaatgcc aaaagtaaag gtgtaaagga
     9181 tggaattatt gttgatattg atgcagcagc aactgctatc aagtcagcca tttcccaagc
     9241 ggaagaaaag gcaggcattt cgattaaatc agtgaatgtc ggcttgcctg gtaatctttt
     9301 gcaggtagaa ccaactcagg ggatgattcc agtaacatct gatactaagg aaattacgga
     9361 tcaagatgtt gaaaatgttg tcaaatcagc tttgacaaag agtatgacac ctgaccgtga
     9421 agtcattacc tttattcctg aagaatttat tgtggatggt ttccaaggga ttcgtgaccc
     9481 acgtggcatg atgggggttc gccttgaaat gcgtggtttg ctttatacag gacctcgtac
     9541 tatcttgcac aatttgcgta agacggttga gcgtgcaggt gttcaggttg aaaatgttat
     9601 catttcacca ctagcaatgg ttcagtctgt tttgaacgaa ggggaacgtg aatttggtgc
     9661 tacagtgatt gatatggggg caggtcaaac gactgtcgct acaatccgta atcaagaact
     9721 ccagttcaca catattctcc aagaaggtgg agattatgta actaaagata tctccaaggt
     9781 tttgaaaacc tctcgcaaat tagcggaagg cttgaaactg aattacgggg aagcctatcc
     9841 gcctcttgca agcaaagaaa ccttccaagt agaggttatt ggagaagtag aagcagtcga
     9901 agtgacggaa gcctacttgt cagaaattat ttctgcacga atcaagcaca tccttgaaca
     9961 aatcaagcaa gaattagata gaaggcgtct attggacctc cctggtggta ttgtcttaat
    10021 cggtgggaat gccattttac caggtatggt tgagcttgct caggaagtct ttggcgtccg
    10081 tgtcaagctt tatgttccaa atcaagttgg tatccgtaat ccagcctttg cgcatgtgat
    10141 tagtttatca gaatttgcgg gtcaattaac agaagttaat cttttggctc agggagcgat
    10201 aaaaggtgag aatgacttaa gtcatcagcc aattagtttt ggtgggatgt tgcaaaaaac
    10261 agctcagttt gtacaatcaa cgcctgttca accagctcct gctccagaag tagagccggt
    10321 ggcgcctaca gaaccaatgg cggatttcca acaagcttca caaaataaac cgaaattagc
    10381 agatcgtttc cgtggcttga tcggaagcat gtttgacgaa taaagaggaa aaataaatta
    10441 tgacattttc atttgataca gctgctgctc aaggggcagt gattaaagta attggtgtcg
    10501 gtggaggtgg tggcaatgcc atcaaccgta tggtcgacga aggtgttaca ggcgtagaat
    10561 ttatcgcagc aaacacagat gtacaagcat tgagtagtac aaaagctgag actgttattc
    10621 agttgggacc taaattgact cgtggtttgg gtgcaggagg tcaacctgag gttggtcgta
    10681 aagccgctga agaaagcgaa gaaacactga cggaagctat tagtggtgcc gatatggtct
    10741 tcatcactgc tggtatggga ggaggctctg gaactggagc tgctcctgtt attgctcgta
    10801 tcgccaaaga tttaggtgcg cttacagttg gtgttgtaac acgtcccttt ggttttgaag
    10861 gaagtaagcg tggacaattt gctgtagaag gaatcaatca acttcgtgag catgtagaca
    10921 ctctattgat tatctcaaac aacaatttgc ttgaaattgt tgataagaaa acaccgcttt
    10981 tggaggctct tagcgaagcg gataacgttc ttcgtcaagg tgttcaaggg attaccgatt
    11041 tgattaccaa tccaggattg attaaccttg actttgccga tgtgaaaacg gtaatggcaa
    11101 acaaagggaa tgctcttatg ggtattggta tcggtagtgg agaagaacgt gtggtagaag
    11161 cggcacgtaa ggcaatctat tcaccacttc ttgaaacaac tattgacggt gctgaggatg
    11221 ttatcgtcaa cgttactggt ggtcttgact taaccttgat tgaggcagaa gaggcttcac
    11281 aaattgtgaa ccaggcagca ggtcaaggag tgaacatctg gctcggtact tcaattgatg
    11341 aaagtatgcg tgatgaaatt cgtgtaacag ttgttgcaac gggtgttcgt caagaccgcg
    11401 tagaaaaggt tgtggctcca caagctagaa ctgctactaa ctaccgtgag acagtgaaac
    11461 cagctcattc acatggcttt gatcgtcatt ttgatatggc agaaacagtt gaattgccaa
    11521 aacaaaatcc acgtcgtttg gaaccaactc aggcatctgc ttttggtgat tgggatcttc
    11581 gccgtgaatc gattgttcgt acaacagatt cagtcgtttc tccagtcgag cgctttgaag
    11641 ccccaatttc acaagatgaa gatgaattgg atacacctcc atttttcaaa aatcgttaag
    11701 taaatgaatg taaaagaaaa tacagaactt gtttttcgag aagttgcaga ggctagtctg
    11761 agtgctaatc gagagagtgg ttcggtctct gtcattgcag ttaccaagta tgtagatgta
    11821 ccgacagcgg aagccttgct tccgctaggt gttcatcata tcggtgaaaa tcgtgtagat
    11881 aagtttctgg aaaaatatga agctttaaaa gatcgagatg tgacttggca tttgattggt
    11941 accttgcaaa gacgtaaggt gaaagatgtc attcaatacg ttgattattt ccatgcattg
    12001 gactcagtaa agctagcagg ggaaattcaa aaaagaagtg accgagtcat caagtgtttc
    12061 cttcaagtaa atatttctaa agaagaaagc aaacacggtt tttcgagaga ggaactgctg
    12121 gaaatcttgc cagagttagc cagactagat aagattgaat atgttggttt aatgacgatg
    12181 gcaccttttg aggctagcag tgagcagttg aaagagattt tcaaggcgac ccaagattta
    12241 caaagagaaa ttcaagagaa acaaattcca aatatgccta tgaccgagtt aagtatggga
    12301 atgagtcgtg attataaaga agcgattcaa ttcggttcca cttttgttcg tataggtaca
    12361 tcatttttta agtaggagag aaccatgtct ttaaaagata gattcgatag atttatagat
    12421 tattttacgg aggatgagga ttcaagtctc ccttatgaaa aaagagatga gcctgtgttt
    12481 actccagtaa attcttcaca ggaaccggct ctcccaatga atcaaccttc acagtcggct
    12541 ggtacaaaag agaacaatat caccagactt catgcaagac aacaggaatt ggcaaatcag
    12601 agtcagcgtg caacggataa ggtcattata gatgttcgtt atcctagaaa atatgaggat
    12661 gcaacagaaa ttgttgattt attggcagga aacgaaagta tcttgattga ttttcagtat
    12721 atgacagagg tgcaggctcg tcgttgtttg gactatttgg atggagcttg tcatgtttta
    12781 gctggaaatt tgaaaaaggt agcttctacc atgtatttgt tgacaccagt gaatgttatt
    12841 gtaaatgttg aagatatccg tttaccagat gaagatcaac agggtgagtt cggttttgat
    12901 atgaagcgaa atagagtacg ataatgattt ttttaattcg tatgatttat aatgcagtgg
    12961 atatttactc cctgattttg gtagccttcg ctgtcatgtc ttggtttcca ggtgcctacg
    13021 aatccagttt aggtcgttgg attgtagcgt tggtgaaacc agtgcttgct cccttgcaac
    13081 gcctgccttt acagatagcg ggtcttgatt tatctgtttg ggttgcgatt gttttggttc
    13141 gatttttagg agaaaaccta gtgcgttttc tggcgatgat aggatgaata aagggattta
    13201 tcagcatttc tccatagaag atcgtccatt tcttgacaag ggaatggaat ggataaagaa
    13261 ggtagaagat agctatgctc cttttttaac tccttttatc aatcctcatc aggagaagct
    13321 attaaagatt ttggccaaaa cctatggtct tgcttgtagc agtagtgggg aattcgtatc
    13381 gagtgagtat gttcgagttt tattataccc agattatttc caaccagagt tttcagattt
    13441 tgaaatatct ctccaggaaa ttgtgtattc caataaattt gaatatttaa cgcatgctaa
    13501 gattttaggg acagtcatca atcaattagg gattgaacgg aaactttttg gagatatcct
    13561 agtagatgaa gaacgggcgc agattatgat taatcagcag tttcttcttc tctttcaaga
    13621 tggactaaag aaaattggtc gtatacctgt ttcgctggag gaacgtcctt tcaccgagaa
    13681 aatagataag ctagaacagt atcgagaact ggatttatct gtgtctagtt ttcgattaga
    13741 tgttctttta tcaaatgttt tgaaactatc taggaatcaa gcaaaccagt tgattgaaaa
    13801 gaaacttgtc caagtaaatt atcatgtggt agacaaatca gattacactg ttcaagttgg
    13861 agacttgatt agtgtgagaa aatttggtcg cttgagatta cttcaagata agggacaaac
    13921 gaaaaaagag aagaaaaaaa taaccgtcca gttattatta agtaagtgag gaatagaatg
    13981 ccaattacat cattagaaat aaaggacaag acttttggaa ctcgattcag aggttttgat
    14041 ccagaagaag tcgatgaatt tttagatatt gtggttcgtg attacgaaga tcttgtgcgt
    14101 gcgaatcatg ataaaaattt gcgtattaag agtttagaag agcgtttgtc ttactttgat
    14161 gaaataaaag attcattgag ccagtctgta ttgattgctc aggatacagc tgagagagtg
    14221 aaacaggcgg cgcatgaacg ttcaaacaat atcattcatc aagcagagca agatgcgcaa
    14281 cgcttgttgg aagaagctaa atataaggca aacgagattc ttcgtcaagc aactgataat
    14341 gctaagaaag tcgctgttga aacagaagaa ttgaagaaca agagccgtgt cttccaccaa
    14401 cgtctcaaat ctacaattga gagtcagttg gctattgttg aatcttcaga ttgggaagat
    14461 attctccgtc caacagctac ttatcttcaa accagtgatg aagcctttaa agaagtggtt
    14521 agcgaagtac ttggagaacc gattccagct ccaattgaag aagaaccaat tgatatgaca
    14581 cgtcagttct ctcaagcaga aatggaagaa ttacaagctc gtattgaggt agccgataaa
    14641 gaattgtctg aatttgaagc tcagattaaa caggaagtgg aaactccaac tcctgtagtg
    14701 agtcctcaag ttgaagaaga gcctctgctc gtccagttgg cccaatgtat gaagaaccag
    14761 aagtagctcc agtgcatccg acaggtccaa caccagctac agaaactgtt gattcagcac
    14821 cgggatttga agcaccgcaa gaatctgtta caattttata agaaatattc tgagaacaat
    14881 atcttatcct tatattccca gcgagcagga gatggtgtga gtcctgcatt ccctatcgat
    14941 aagattatcc tctcaaacta tcaagtctga atctagtaag atttgacgtt ccccacgtta
    15001 cgggataaga gggagaaaga ctaaaacttt ttccgaataa aggtggtacc acgattttcg
    15061 tcctttttgg aagtcgtggt ttttaatttg ttattattta taaaggagat accatgaaac
    15121 taaaagatac ccttaatctt gggaaaacag ctttcccaat gcgtgcaggc cttccgacca
    15181 aagagccagt ttggcaaaag gaatgggaag atgcaaaact ttaccaacgt cgtcaagaac
    15241 taaatgaagg gaaaccgcat tttgtcttgc atgatggccc tccatacgca aacggaaata
    15301 tccacgttgg acatgccatg aatcatatct caaaagatat catcattcgt tctaagtcta
    15361 tgtcaggttt taacgcacct tatatcccag gttgggatac tcatggtctg ccaatcgagc
    15421 aagttttggc aaagcaaggt gtgaagcgca aagaaatgga cttggttgag tacttgaaac
    15481 tctgtcgtga gtacgctctt tctcaagttt ataaacaacg tgatgatttc aaacgcttgg
    15541 ggatgtcagg tgactgggaa aatttatatg tgactttaac tccagactat gaagcagccc
    15601 aaatccgtgt ctttggtgag atggctaata agggttatat ctaccgtggt gctaagccag
    15661 tttactggtc atggtcatct gagtcagccc ttgccgaagc ggaaattgaa taccatgatt
    15721 tggtttcgac ttcactttat tatgccaata aggtaaaaga tggcaaaggt atcctagata
    15781 cagatactta tatcgtagtc tggacaacaa ctccatttac catcacagct tctcgtggtt
    15841 tgactgttgg tgcagatatt gattacgttt tggttcaacc tgctggtgaa actcgtaagt
    15901 ttgtcgttgc tgcagaattg ttgactagct tgtctgagaa atttggctgg gctgatgttc
    15961 aagtgttggc aacttaccgt ggtcaagaac tcaaccacat cgtaacagaa cacccatggg
    16021 atacagctgt agatgagttg gtaatccttg gtgatcacgt taccactgac tctggtacag
    16081 gtatcgtcca tacagcccct ggttttggtg aggacgacta caatgttggt attgctaatg
    16141 gtcttgaagt cgcagtgact gttgacgaac gcggtatcat gatggcgaat gctggtcctg
    16201 agtttgaagg tcagttctac gacaaggttg taccaactgt tattgaaaaa cttggtaacc
    16261 tccttctagc ccaagaagaa atctctcact catacccatt tgactggcgt actaagaaac
    16321 caatcatctg gcgtgcagtt ccacaatggt ttgcctcagt ttcaaaattc cgccaagaaa
    16381 tcttggatgc tattgataaa gttaaattcc atacagaatg gggtaaagta cgtctatata
    16441 atatgattcg tgaccgtggt gactgggtta tctctcgtca acgtgcttgg ggtgttccac
    16501 ttccaatctt ctatgcagaa gacggtacag ctatcatgac agctgagact attgaacatg
    16561 tggcgcaact ctttgaagta catggttcaa gcatttggtg ggaacgtgat gccaaggacc
    16621 tcttgccaga aggatttaca catccaggtt ctccaaatgg ggagttcaag aaagaaacag
    16681 atattatgga tgtatggttt gactcaggtt catcatggaa tggtgttttg gtaaatcgtc
    16741 caaatctgac ttatccagct gacctttacc tagaaggttc tgaccaatac cgtggttggt
    16801 ttaactcatc acttatcaca tctgttgcca accatggcgt agcaccttac aaacaaatct
    16861 tgtcacaagg ttttgccctt gatggtaaag gtgagaagat gtctaaatct cttggaaata
    16921 ccattgctcc aagcgatgtt gaaaaacaat tcggtgctga aatcttgcgt ctctgggtaa
    16981 caagtgttga ctcaagcaat gacgtgcgta tctctatgga tattttgagc caagtttctg
    17041 aaacttaccg taagattcgt aacactcttc gtttcttgat tgccaataca tctgacttta
    17101 acccagctca agatacagtc gcttacgatg agcttcgttc agttgataag tacatgacga
    17161 ttcgctttaa ccagcttgtc aagaccattc gtgatgccta tgcagacttt gaattcttga
    17221 cgatctacaa ggccttggtg aactttatca acgttgactt gtcagccttc taccttgatt
    17281 ttgccaaaga tgttgtttac attgaaggtg ccaaatcact ggaacgccgt caaatgcaga
    17341 ctgtcttcta tgacattctt gtcaaaatca ccaaactctt gacaccaatc cttcctcaca
    17401 ctgcggaaga aatttggtca tatcttgagt ttgaaacaga agacttcgtc caattgtcag
    17461 agttaccaga ggctcaaact tttgctaatc aagaagaaat cttggataca tgggcagcct
    17521 tcatggactt ccgtggacaa gcacaaaaag ccttggaaga agctcgtaat gcaaaagtta
    17581 tcggtaaatc acttgaagca cacttgacag tttatcaaaa tgaagttgtg aaaactctac
    17641 tcgaagcagt aaacagcaat gtagctcaac ttttgatcgt gtctgagttg accatcgtag
    17701 aaggaccagc tccggaagct gcccttagct tcgaagatgt agccttcaca gttgaacgtg
    17761 ctactggtga agtatgtgac cgttgccgtc gtatcgaccc aacaacagca gaacgcagct
    17821 accaggcagt tatctgtgac cactgtgcaa gcatcgtaga agaaaacttt gcggaagcag
    17881 tcgcagaagg atttgaagag aagtaaggtt gaaaagtcta gagaaaactc aatttgagaa
    17941 gaaaagacaa ctaatcttat agtctataaa acgcatagta tcacgttttt gaacacatga
    18001 tatgatgcgt tttttattta ttttaaaaat ttgcgaggta tgacttttta tactcaacaa
    18061 gaatcaaaga gaaacttagc aagctaacag tagtaagata aaataggaat ttgatattag
    18121 ggataagatt ggtaaatagt gtaatatttt tacaacaata aat
//
LOCUS       DAVHSO010000046        18104 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.046, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000046 DAVHSO010000000
VERSION     DAVHSO010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18104)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18104)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18104
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.046"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            352..1398
                     /gene="pheS"
                     /locus_tag="VVR18_001546"
     CDS             352..1398
                     /gene="pheS"
                     /locus_tag="VVR18_001546"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HEU6033046.1"
                     /translation="MSTIEEQLKALREETLASLKQITAGNEKEMQDLRVSVLGKKGSL
                     TEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVAAQLASESIDVTL
                     PGRPVATGHRHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERMNLPKDHPARDM
                     QDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQ
                     IEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSVEVDVSCFKCGG
                     EGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERVAMLRYGINDIR
                     GFYQGDVRFSEQFK"
     gene            1398..1907
                     /locus_tag="VVR18_001547"
     CDS             1398..1907
                     /locus_tag="VVR18_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033047.1"
                     /translation="MIRKVEMADVEVLAKIAKQTFRETFAYDNTEEQLQEYFEEAYSL
                     KTLSTELGNPDSETYFIMHEEEIAGFLKVNWGSAQTERELEDAFEIQRLYVLQKFQGF
                     GLGKQLFEFALELATKNSFSWAWLGVWEHNTKAQAFYNRYGFEKFSQHHFMVGQKVDT
                     DWLLRKKLR"
     gene            1984..4389
                     /locus_tag="VVR18_001548"
     CDS             1984..4389
                     /locus_tag="VVR18_001548"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HEU6033048.1"
                     /translation="MLVSYKWLKELVDIDVPSQELAEKMSTTGIEVEGVESPAAGLSK
                     IVVGEVLSCEDVPETHLHVCQVNVGEEEERQIVCGAPNVRAGIKVMVALPGARIADNY
                     KIKKGKIRGLESLGMICSLGELGISDSVVPKEFADGIQILPENAVPGEEVFSYLDLDD
                     EIIELSITPNRADALSMCGVAHEVAAIYDKAVNFKEFTLTETNESAADALSVSIGTDK
                     APYYAARILDNVTIAPSPQWLQNLLMNEGIRPINNVVDVTNYILLYFGQPMHAFDLDT
                     FEGTDIRVREARAGEKLVTLDGEERDLDVNDLVITVADKPVALAGVMGGQATEISEKS
                     SRVVLEAAVFNGKSIRKTSGRLNLRSESSSRFEKGINVATVNEALDAAASLIAELAGA
                     TVRKGIVSAGELDTSDVEVSSTLADVNRVLGTELSYADVEDVFRRLGFGLSGNADSFT
                     VRVPRRRWDITIEADLFEEIARIYGYDRLPTSLPKDDGTAGELTATQKLRRQVRTIAE
                     GAGLTEIITYTLTTPEKAVEFTAQPSNLTELMWPMTVDRSVLRQNMISGILDTVAYNV
                     ARKNKNLALYEIGKVFEQTGNPKEELPNEINSFAFALTGLVAEKDFQTAAVPVDFFYA
                     KGILEALFARLGLQVTYTATSEIASLHPGRTAVISLGDQVLGFLGQVHPVTAKAYDIP
                     ETYVAELNLSAIEAALQPAAPFVEITKFPAVSRDVALLLKAEVTHQEVVDAIQAAGVK
                     RLTDIKLFDVFSGEKLGLGMKSMAYSLTFQNPEDSLTDEEVARYMEKIQASLEEKVNA
                     EVR"
     gene            complement(4457..5458)
                     /locus_tag="VVR18_001549"
     CDS             complement(4457..5458)
                     /locus_tag="VVR18_001549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000597989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEU6033049.1"
                     /translation="MIKTFLSALSVILFVIPIITYSFFPSSNLNIWLSTRPILAQIYA
                     FPLATATMASILSFVFFSLSFYNKNKQIRFYSGILLLLSLILLLFGTDKTLSSASNKT
                     KTLKLVTWNVANQIEAQHIERIFSHFDADMAIFPELATKIRGEQENQRIKLLFHQVGL
                     SMANYDIFTSPPTNSGIAPVTVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQNIPDII
                     ALHTAPPLPGLMEIWKQDLNIIHNQLASKYPKAIIAGDFNATMRHGALAKISSHRDAL
                     NALPPFKRGTWNSQSPKLFNATIDHILLPKNHYYVKDLDIVSFQNSDHRCIFTEITF"
     gene            5614..6059
                     /locus_tag="VVR18_001550"
                     /pseudo
     CDS             5614..6059
                     /locus_tag="VVR18_001550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            6185..6451
                     /locus_tag="VVR18_001551"
     CDS             6185..6451
                     /locus_tag="VVR18_001551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033050.1"
                     /translation="MEGCPSELFSKEEILESDMRVAIMSELIEARNKQGISQKKLEEL
                     SGVSQPVIARMETGKTSPQLDTVLKVLASLGKILAVVRLEQGKS"
     gene            6711..8960
                     /gene="metE"
                     /locus_tag="VVR18_001552"
     CDS             6711..8960
                     /gene="metE"
                     /locus_tag="VVR18_001552"
                     /EC_number="2.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="HEU6033051.1"
                     /translation="MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAK
                     HWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQG
                     EKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVG
                     PFTFLQLSDFEEGVKADDFVDSLVAAYQEVFAKLAELGATRIQLDEAALVKDLTAEEK
                     ALFLNLYNKLLADKKGLEVLLQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVK
                     GGFPADKTLYVGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEE
                     FEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAG
                     LTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKE
                     YDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGM
                     RGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKD
                     STLQIALAIKDEVLDLEVAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVH
                     STVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVG
                     PGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVE
                     AAKAAREKL"
     gene            9024..9890
                     /gene="metF"
                     /locus_tag="VVR18_001553"
     CDS             9024..9890
                     /gene="metF"
                     /locus_tag="VVR18_001553"
                     /EC_number="1.5.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000089969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="HEU6033052.1"
                     /translation="MSRQTPSLSFEVFPPNPAVGNGNIISALQDMQELAPHFISVTAS
                     NNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALR
                     GDIIPDVEPQKDFRYATDLIEFIKERAPHFDIIGACYPEGHPDSPNQISDIQNLKKKV
                     DAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIH
                     LPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQ
                     ATHALFNHQSLG"
     gene            10449..12662
                     /gene="pnp"
                     /locus_tag="VVR18_001554"
     CDS             10449..12662
                     /gene="pnp"
                     /locus_tag="VVR18_001554"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HEU6033053.1"
                     /translation="MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAV
                     MSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFA
                     EGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQII
                     INPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQE
                     EIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQAVKDQVT
                     AVYEEKYANHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVV
                     DFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGE
                     TGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGT
                     LALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITAL
                     QMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVD
                     KIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKV
                     DEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKI
                     DEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHHKDHKPKKEFTETPKDSE"
     gene            12678..13295
                     /gene="cysE"
                     /locus_tag="VVR18_001555"
     CDS             12678..13295
                     /gene="cysE"
                     /locus_tag="VVR18_001555"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000539958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HEU6033054.1"
                     /translation="MGWWRETIDIVKENDPAARTTLEVLLTYPGVKALAAHRLSHFLW
                     KHSFKLLARMHSQFWRFWTQIEIHPGAQIDSGVFIDHGSGLVIGETAIVEKGVLLYHG
                     VTLGGTGKDCGKRHPTVRKGALISAHAQVIGPVEIGENAKVGAAAVVVADVPSDVTVV
                     GIPAKIVRLHGKKDEPVIHEVEEKREYYVNKLEQAKDASHRSSGL"
     gene            13307..14191
                     /locus_tag="VVR18_001556"
     CDS             13307..14191
                     /locus_tag="VVR18_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033055.1"
                     /translation="MIQARNKLSQEELSEAKKVINCCQNYDGTYRDPYLSNMLNFDPN
                     MPAFFLYYEKGKLVGLLTVYADDQDVEVTILVHPGHRRQGIARALFTSFERETASFPI
                     RSVTFQTERIFLENHPDFASNWGLIEDEETETWLGKDRRPYPLANVSHLEILLADSSY
                     QDQISQLKFQAFSEEHESREVVDRYVAEALKDPESRLYILLKAGQVIGTCTVDLSSDT
                     NYFYGLAISEPERGKGYGSYLAKSLVNQLIEQNDKEFQIAVEDSNVGAKRLYEKIGFV
                     KQTQVVYLNEKGARDSEV"
     gene            14278..15621
                     /locus_tag="VVR18_001557"
     CDS             14278..15621
                     /locus_tag="VVR18_001557"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002916477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HEU6033056.1"
                     /translation="MIKIYDTMSRDLREFVPIEDGKIKMYVCGPTVYNYIHVGNARST
                     VAFDTIRRYFEYRGYKVAYISNFTDVDDKIINRAREEGITPQEVADKYIAAFREDVTA
                     LGVKPATRHPRVVEFMADIIRFVEDLIEKGFAYESQGDVYFRVEKSHNYAKLANKTLE
                     DLELGASGRTDEETARKENPVDFALWKSSKPGEISWDSPWGPGRPGWHIECSVMSTEI
                     LGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKAFANYWMHNGFVNIDNVKMSKSLGNF
                     ITVHDALKTLDGQVLRFFFATQHYRKPINFTEKAVRDAETNLKYLKNTYEQPFTGNVD
                     AQELQNFKDKFVAAMDEDFNAANGITVVFEMAKWINSGNYDASVKQALADMLEIFGIV
                     FVEEVLDAEIEDLIQKRQEARANRDFATADQIRDQLVTQGIKLLDTKDGVRWTRD"
     gene            15614..16000
                     /locus_tag="VVR18_001558"
     CDS             15614..16000
                     /locus_tag="VVR18_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HEU6033057.1"
                     /translation="MIDVNLINGIALAFEGDAVYSMYIRRHLILKGMTKPNKLHQEAT
                     KYVSAKAQARLIALMLEEQVLTEKEEEIYKRGRNTNSHTKAKNADVVTYRMSTGFEAV
                     MGYLHMTENLERLESLVSWCIQKVEG"
     gene            16004..16888
                     /locus_tag="VVR18_001559"
     CDS             16004..16888
                     /locus_tag="VVR18_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PucR family transcriptional regulator"
                     /protein_id="HEU6033058.1"
                     /translation="MREKELQDWFPEARISDQPVEKEGYLTLPLASQQWILLEEAGLS
                     EREKQLVALLTQQEQARSLNPWYSYLVEGKGQAPQVFKKIQLVYCHLSYFQQENLASW
                     LDMMRTLFPNCQTVLQVGVQDYVFVLQQDKYTSVRDILSDTIEAVEYDFGLRLSIMLG
                     QVWSQTGHQALSDLIKAERDLFKTWWRQGHQGVHTFSQLYLWSMGERLVDLKPIKECL
                     HQMILDQDQIQEIILSLWENSAVLTKTAQQLYLHRNSLQYKIDKWEELTGLQLKELTD
                     LTLCYQLILGSLSTIVGL"
     gene            17025..17624
                     /locus_tag="VVR18_001560"
     CDS             17025..17624
                     /locus_tag="VVR18_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033059.1"
                     /translation="MQILCYFTITVVAKPNNSGEVHLDVSIEDNQGGSGHNFSSVSSS
                     SQTAKYEETGYNNNSSLYTTIDKTSDATALLKLKLNNVDNQPATEVPSSGITVKLNAK
                     DNAGNWTSASNKKEITVKIVSAKPTYPDKILVKNPDNIKDTEKNAIIEKLKEANKNYP
                     AGAPTFAKGEGEHANDIVATYSDGTTYYVPLNDVTKYAR"
     gene            17767..17937
                     /locus_tag="VVR18_001561"
                     /pseudo
     CDS             17767..17937
                     /locus_tag="VVR18_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
BASE COUNT         5455 a         3486 c         4111 g         5052 t
ORIGIN      
        1 actttcccaa tcgatttgtt ctcatcttat ttcaatccgc tataaagtta gataagaata
       61 agctaacaag cagaagtaag ataggtcttg caagaatggt aaaaatctga taaactaagt
      121 agtaattgaa taggaatctg aaagactagt agcccaaggg aagtatatca gggaggagag
      181 ccgtgactgc aagctctcta tatgaaagct gggtgaattc acttgcgcat ggatttagaa
      241 atgaaggtct gacttgtcag atgaaaacgg atggtaccgc gtgtcaacgc tccgagtgga
      301 gtttttggca tgtggttttc tttttatcta cgagagactg atggaggaaa tatgtcaact
      361 attgaagaac aattaaaagc gcttcgcgaa gaaacgctgg ctagcttgaa gcagattact
      421 gctggaaatg aaaaagagat gcaagatttg cgtgtctctg tccttggtaa aaagggttcg
      481 ctcactgaaa tcctcaaagg gatgaaagat gtttctgctg agatgcgtcc aatcatcggg
      541 aaacacgtca atgaagctcg tgatgtcttg acagctgctt ttgaagaaac agctaagctc
      601 ttggaagaaa agaaagtcgc ggctcaactg gctagcgaga gtatcgatgt gacgcttcca
      661 ggtcgtccag ttgcgactgg tcaccgtcac gttttgacac aaaccagtga agaaatcgaa
      721 gatatcttca tcggtatggg ttatcaagtc gtggatggtt ttgaagtgga gcaagactac
      781 tataactttg aacgtatgaa ccttccaaaa gaccacccag ctcgtgatat gcaggatact
      841 ttctatatca ctgaagaaat cttgctccgt acccacacgt ctccagttca ggcgcgtgct
      901 atggatgccc atgatttttc taaaggtcct ttgaagatga tctcgccagg gcgtgtcttc
      961 cgtcgcgata cggacgatgc gacccacagt caccaattcc accaaatcga aggcttggta
     1021 gttgggaaaa atatctctat ggctgatctt caaggaacgc ttcagttgat tgtccaaaaa
     1081 atgtttggtg aagagcgtca aattcgtttg cgtccatctt acttcccatt cacagagcca
     1141 tctgttgagg tggatgtttc ttgcttcaag tgtggtggag aaggctgtaa tgtatgtaag
     1201 aaaacaggtt ggatcgaaat tatgggggcc ggtatggttc acccacgtgt ccttgaaatg
     1261 agtggtatcg atgcgactgt atactctggc tttgcctttg gtcttggaca agagcgtgta
     1321 gctatgctcc gttatggaat caacgatatc cgtggattct accaaggaga tgtccgcttc
     1381 tcagaacagt ttaaataatg attagaaaag tagaaatggc agatgttgag gtgttggcta
     1441 aaattgccaa acaaaccttt cgtgaaacct ttgcgtatga taatacggaa gagcagttac
     1501 aggaatactt tgaagaggct tatagtctaa aaactttgtc aactgagttg ggaaatcctg
     1561 actctgaaac ctatttcatt atgcatgagg aggagatagc tggttttctc aaagtcaact
     1621 ggggaagtgc tcaaactgag agagaattag aggacgcttt tgaaattcaa cgcctctatg
     1681 tgctacaaaa attccaagga tttggactag gtaagcaact gtttgaattc gcacttgaac
     1741 ttgctacaaa aaatagtttt tcttgggctt ggctaggtgt ttgggagcat aatacaaaag
     1801 ctcaagcgtt ttataatcga tatggttttg aaaaatttag ccaacatcat tttatggttg
     1861 gtcaaaaagt agatacggat tggttactga gaaagaaatt aaggtaagaa gaggattctt
     1921 ctattgaaat gataggaaag gaaaagaacc agtgtggcaa tggtcattct ggagaactaa
     1981 attatgcttg tatcttataa atggttaaaa gaattggtgg acattgatgt gccatcacaa
     2041 gagttggctg aaaaaatgtc aactacaggg atcgaggtag agggtgtcga atcaccagct
     2101 gctggtctct caaaaattgt cgtcggtgag gtcttgtctt gcgaagatgt gccagagact
     2161 cacctccatg tttgtcaggt taacgttggc gaagaagaag agcgtcagat cgtttgtggt
     2221 gccccaaatg tgcgtgctgg gatcaaggtc atggtggctc ttccaggagc tcgtatcgct
     2281 gataactaca aaatcaaaaa aggaaaaatc cgtggtttgg agtcacttgg aatgatctgt
     2341 tcacttggtg aattgggaat ttctgactca gttgtgccta aggaattcgc agatggcatc
     2401 caaatcttgc cagaaaatgc cgtgccaggt gaggaagtct tttcttacct agacttggat
     2461 gatgaaatca tcgaactttc catcacacca aaccgtgcag atgccctttc tatgtgtgga
     2521 gtggctcacg aagtggcagc catctatgac aaggcagtca actttaaaga atttactcta
     2581 acagaaacta atgaatctgc ggcagatgcc ctttctgtca gcattgggac agacaaggcg
     2641 ccttactatg cagctcgtat cttggacaat gtgactatcg caccaagtcc acaatggttg
     2701 caaaaccttc tcatgaacga aggcatccgt cccatcaata acgttgtaga cgtgacaaac
     2761 tacatcctgc tctactttgg tcaacctatg catgcttttg acttggacac atttgaaggg
     2821 actgacatcc gtgtgcgtga agcgcgtgct ggtgaaaaat tggtgacctt ggacggtgaa
     2881 gaacgtgact tggacgtgaa tgacctagtc atcactgtcg cagacaagcc agtagccctt
     2941 gcaggtgtca tgggtggtca agcaacagaa atctctgaaa aatctagtcg tgttgtcctt
     3001 gaagctgctg ttttcaatgg caaatctatc cgtaagacaa gtggtcgcct gaaccttcgt
     3061 tctgagtcat cttctcgctt tgaaaaagga attaatgtgg caacagttaa tgaagccctt
     3121 gatgcggcag ctagcctgat tgcggaactt gcaggtgcga cggtgcgtaa gggcatcgtt
     3181 tcagcgggtg agcttgatac ttcagatgta gaagtttctt caacccttgc tgatgttaac
     3241 cgtgtcctcg gaactgagct gtcttatgct gatgtagaag acgtcttccg tcgtcttggc
     3301 tttggtcttt ctggaaatgc agacagcttt acagtcagag tcccacgtcg tcgttgggat
     3361 atcacaatcg aagctgacct ctttgaagaa attgctcgta tctatggtta tgaccgcttg
     3421 ccaactagtc taccaaaaga cgatggtaca gcaggtgaat tgacagccac acaaaaactc
     3481 cgccgtcaag ttcgtactat tgctgaagga gcaggtttga cagaaatcat cacctatact
     3541 ctaacaactc ctgaaaaagc agttgagttt acggctcaac caagtaacct tacggaactc
     3601 atgtggccaa tgactgtgga tcgttcagtc ctccgtcaaa atatgatttc aggtatcctt
     3661 gataccgttg cctacaacgt ggctcgtaag aataaaaact tggcccttta cgagattgga
     3721 aaagtctttg aacaaacagg taatccaaaa gaagaacttc caaatgagat caacagcttt
     3781 gcctttgcct tgacaggctt ggttgctgaa aaagatttcc aaacagcagc agttccagtt
     3841 gatttcttct atgctaaggg aatccttgaa gccctatttg ctcgtttggg actccaagta
     3901 acctatacag caacatctga aatcgctagc cttcatccag gtcgtacagc cgtgatttca
     3961 ctcggtgacc aagttcttgg tttccttggc caagtgcatc cagtcactgc taaggcttat
     4021 gatattccag aaacgtatgt agctgagctt aacctttcag ctatcgaagc tgcgcttcag
     4081 ccagcggctc catttgtaga aatcaccaaa ttcccggcag tcagccgtga cgttgccctt
     4141 ctcctcaagg cagaagtgac tcatcaagaa gttgtagatg ctatccaagc tgccggcgtg
     4201 aaacgtttga cagatatcaa actctttgac gtcttctcag gtgagaaatt gggacttggt
     4261 atgaagtcca tggcttatag cttgaccttc caaaatccag aagatagctt aacggacgaa
     4321 gaagtcgcac gctatatgga aaaaatccaa gcttctctcg aagaaaaagt caatgcagaa
     4381 gtgcgttaaa cgatagtatg atacaaatca cccctctagt ttatgaacac tagaggggtg
     4441 attttatata aaataattaa aatgtgattt ctgtaaaaat acatctatga tcagagtttt
     4501 gaaaacttac aatgtctaaa tctttaacat agtagtggtt tttaggcaat aaaatatgat
     4561 ctattgttgc attaaaaagt tttggacttt ggctattcca agttcctctt ttaaagggtg
     4621 gaagtgcatt caatgcgtcc ctatgagagc ttatttttgc aagtgctcca tgacgcatag
     4681 ttgcattaaa atcacctgca ataatagcct ttggatattt tgaagccaat tgattatgaa
     4741 tgatgtttaa gtcttgcttc cagatttcca ttaaacctgg cagaggagga gcagtatgca
     4801 aggcaatgat atctggtata ttttgttttc tcgaatgtaa tacaattgtc ccgaaccgtg
     4861 ttgtatgaaa agttttagct tctgtataga aaccataact tttcttgaca atcacagtca
     4921 caggagctat tccactattg gtaggtggag aagtgaaaat atcatagttg gccatagaaa
     4981 gtccaacttg atgaaacaat agtttgattc tctggttttc ttgctcacct ctgatcttgg
     5041 tagctagttc agggaatata gccatatcgg catcaaaatg gctaaaaatt cgctcaatat
     5101 gttgtgcttc tatttgatta gcgacgttcc aagttactaa ttttaaggtt ttagtcttat
     5161 ttgatgcaga agaaagggtt ttatctgttc cgaataatag taatatgagc gatagtaaga
     5221 gcaaaatgcc agagtaaaac cgtatttgtt tatttttatt gtaaaaagat agggaaaaaa
     5281 atacgaaact taaaatagaa gccatagttg cagtagctaa ggggaaggca taaatctgtg
     5341 ccaagatagg tctggtagat agccaaatat taagattaga agatggaaaa aaagaataag
     5401 ttatgatagg gataacaaag agaatgaccg aaagggcaga gagaaatgtt ttaatcattg
     5461 tgtgagtacc tcaatttgca atggttgctc ggagctaatg tgactttgtg actttacttg
     5521 attgatattc tttttcttgt cttcctcata gattaagtac aacccaagta aaaaaagtcc
     5581 aatttaagat tgaaatgatt aaaaggcaca gagatgcaag acaattatac tacaaaaggt
     5641 aaacatttga caatcgatag ccgtcgctta atcgaaagat ggaaaaaaga aggaaaatca
     5701 aatagagaag ttgcctctct acttggaaaa gctcctcaaa ctatccacac tgaaatcaag
     5761 cgtgggacag tccgaaaatg tcttggaaaa gggcgcttca aagaggttta ttctgccgac
     5821 tacgctcaac agtgttatga aaacaatcgc aagcgctcgg tcaagaaatc aagcttgacc
     5881 aaggaactaa aggaaaagat tccactatac ataaccaaaa attttcgcct gaaatgatgg
     5941 ttatggctaa aggggttaac gtgggaattt caaccattta ctattggatt catcgtggaa
     6001 aattggggtt aagcaagcag gatctgcttt atcctagaaa aggaaaatcg cttaagaaat
     6061 aggctagcac caactttaaa cccgctggtc aatctatcga atcataattc gctcattttt
     6121 ttaaaaatac atagacgtaa aagaaagagg gttaagtgat gaagaatagt gctattggga
     6181 gtaattggaa ggatgtccat ctgagctctt tagcaaggag gaaatccttg aaagtgatat
     6241 gcgagtagct atcatgagcg agttgattga agccagaaat aagcaaggaa tcagtcagaa
     6301 aaagctagag gaactcagtg gagtgagtca gcctgttata gctaggatgg agacaggtaa
     6361 gactagtcca cagttggaca cagtcttaaa agtcctagct agtctaggaa agatactagc
     6421 agtcgtccga cttgaacagg ggaaaagttg actagaatca gttatagtct tttctaataa
     6481 caagccatag tcacttataa gaattactaa taacgctttt gagcattcta actaaaatac
     6541 agctaaaaac aagttataaa agggatttga ggcatgtgtc tcaagtcttt ttcttttgtc
     6601 taaaacagag gtatagtttc aaactatatc aaagcctaat tttttacaat tatacagatg
     6661 atttcttttc tgttaagata gtttcaacaa caaattttgg aggacacatc atgtcaacta
     6721 caatcatcgg tttccctcgt ttgggcgaat tccgtgaatt aaaatttaca actgaaaaat
     6781 actttagaaa agaaatctca gaagaagaac ttttagcagc agcaaaagac ttgcgtgcta
     6841 aacactggaa cattgtcaaa gaaaaaggca tcactgaaat tccatcaaat gacttttctc
     6901 actatgataa cttcctagat gcggctttcc ttttcaacgt ggtgcctgca tccgttcaaa
     6961 acttggactt gtctgacctt gagcgctact tcgctttggg acgtggttac cagggagaaa
     7021 aaggggacgt tcgcgccctt ccaatgaaga aatggttcaa cactaactac cactacatcg
     7081 ttcctaaatt tgaaaaagac actcaagtaa aattggctgg tcacaagatt ttcgatgagt
     7141 tccaagaagc aaaagaactt ggattgaaca ctcgtcctgt tcttgtaggt ccattcactt
     7201 tccttcaatt gtcagacttt gaagaaggcg tgaaagcaga cgacttcgta gatagcttag
     7261 tggctgctta ccaagaagtt tttgctaaat tggctgaact tggtgcgact cgcatccaat
     7321 tggatgaagc ggctcttgta aaagacttga cagctgaaga aaaagctctc ttcttgaacc
     7381 tttacaacaa actcttggct gacaaaaaag gtcttgaagt cttgcttcaa acttatttcg
     7441 gtgatgttcg tgacgtatac gctgaccttg taaacttgcc agtagatgct atcggtcttg
     7501 actttgttga aggtaagaaa actcttgaac tcgttaaagg tggcttccca gctgacaaga
     7561 ctctctatgt aggtattgtc aatggtaaaa acatctggcg caacaactac gaaaagagct
     7621 tggctgttct tgagcaaatc ccagctgaaa acatcgtttt gacaagctct tgctcacttc
     7681 ttcatgtgcc atttacaact gctaatgaag aatttgaacc agcactcttg aaccactttg
     7741 cctttgcagt tgaaaaattg gatgaaatcc gtgacttgga tgctatccgc aatggtcaag
     7801 gttcagaagc tcttgcagcc aacaaagaac tctttgcgac tgagcgtgtt ggtgaaaatg
     7861 ctgaacttcg tgcgcgtatc gctggcttga cagacgcaga ctacactcgt ttgccagcct
     7921 ttgcagaacg tgaagctatc caagaagaag ctttcaaact tccagctctt ccaacaacaa
     7981 cgattggttc attccctcaa acaaaagaag ttcgtgccaa acgtttggct taccgtaaag
     8041 gtgaattgtc tcaaaaagag tacgacgctt tccttgctga aacgattgac gaatggatca
     8101 agtggcaaga agatattgac tttgatgtcc ttgttcacgg tgaatttgag cgtaatgaca
     8161 tggttgagta cttcggtcaa aacttgtcag gttacctctt ctctaaaaat ggttgggtac
     8221 agtcatacgg tatgcgtggg gtgaaaccac caatcatctg gggtgatgtc actcgtctta
     8281 accctatcac tgttaaatgg tctagctatg cacaaagtcg tacaaacaaa cctgttaaag
     8341 gtatgttgac tggacctgtt accattctta actggtcatt cccacgtgaa gacatctcta
     8401 tcaaggattc aactcttcaa atcgcccttg ctatcaagga tgaagtactt gaccttgaag
     8461 ttgctggtgt gaagatcatc caaatcgatg aggctgctct tcgtgaaaaa ttgccactcc
     8521 gtcgtagcga ctggtacgaa gactaccttg actgggcaat tcctgccttc cgcttggtac
     8581 actcaacagt agcgccagac acacaaatcc acactcacat gtgttactca gaatttacag
     8641 atatcatccc agctatcgat aacatggatg cagacgttat ttcctttgaa gctagccgtt
     8701 caaaccttga aatcttggac gaactcaaag cgaaaaactt ccaaacagaa gtgggacctg
     8761 gggtttacga tatccactca cctcgtgtac caaatgaagg cgaaatcgac aacacaatcg
     8821 aagccatcct tgctaaagtg ccaagcaaga aagtttggat caaccctgac tgtggtttga
     8881 aaacacgtgg tatcccagaa acaaaagaaa gcttgatccg ccttgttgaa gcagctaaag
     8941 ctgcgcgtga gaaattgtaa gattggattt ctctccatac agtggttgtt caaaaagaaa
     9001 tcaactagaa aaggttatta catatgtcac gccaaacacc gtcactctca tttgaagtgt
     9061 tccctccaaa cccagccgtg ggtaatggta acattatttc agccttgcag gatatgcagg
     9121 agttggctcc ccattttatc agtgtaactg ccagcaataa taaatttaat atcaaggaaa
     9181 cgacggttcg tttggctgac tttatccaaa atgatttggc gattccgacc attgcccact
     9241 tgccagctat ttatctaact aaggacaagg ttgctgaaac tattgctgac ttggacaaag
     9301 ttggggtgca gaaaatcttg gctcttcgtg gggatattat tccagacgtg gaaccacaaa
     9361 aggatttccg ctatgcaacc gacttgattg agtttatcaa ggaacgagcc cctcactttg
     9421 atattattgg agcttgctat ccagaagggc atccagattc gccaaatcag atttcagata
     9481 ttcaaaatct taagaagaaa gtggatgcag gctgttcgag cctcgtaact cagctcttct
     9541 ttgacaatga gcgcttctat gattttcagg acaagtgcat cttggctggg attgatgttc
     9601 ccattcatgc aggaattatg ccaattctga atcgaaatca ggctctccga ctcttgaaga
     9661 cttgtgagaa tatccatctt ccacgcaaat ttaaagccat cttagacaag tatgagcatg
     9721 accctgagtc gctcagagca gcaggacttg cctatgcagt ggaccaaatc gtggacttgg
     9781 taactcagga tgttgccggt gtgcatctct atacgatgaa taatgctgat acagcaaaat
     9841 acatccatca agcaacccat gccttgttta atcaccagtc tctaggataa taaaagcaaa
     9901 ccattcttct caggtgaggg gaatggttcc tttttaatgg taaagacctc actttttaag
     9961 aaaaatatga taaaataaat tctgtacgta cttgatacaa agatgaaggt attaaataat
    10021 acaatgcatt taaactgtaa gatttaacga cacgagtgag tcaaatcgat gttatttgac
    10081 gagagagtta gtaaagcatt tagctaatcg cccgatagcg attagcgtga aagctttaga
    10141 tactttagta ttaaaccttt ctaatgatgt atcttgaaaa ctgaacttgc ctacaactct
    10201 gtggaaaaag ataaatctcc ctaggagcag tcgctccgtc gttcgatttc ctattttcct
    10261 ttgagttgct tgacggcttg gtatcttgag taattgaaca cggccgaaaa gctgtgtaaa
    10321 aaagataaac tgtcttgtct tcatcgaaga cttcgtcagt ttcctatttt tactttgctt
    10381 ttgacgtcct tggtatcttg atctttgtag gcaaggcgta taatttcatc aatccaaagg
    10441 ggattaaaat ggcaaaacaa gtgtttcaaa cgacttttgc gggtcgtgag ttaattgtag
    10501 agactggtca ggttgctaag caagcaaatg gatctgttgt cgtacgttac ggtgagtcaa
    10561 ctgtcttgac tgctgccgtt atgtctaaga aaatggcaac tggggatttc ttcccactcc
    10621 aagtcaacta cgaagaaaaa atgtatgcgg ctgggaagtt tcctggtggc tttatgaaac
    10681 gtgaaggacg tccttcaaca gatgcgacct tgacagcgcg tttgattgac cgtccgattc
    10741 gtcctatgtt tgcggaaggt ttccgtaatg aagtccaagt catcaataca gtgctttctt
    10801 atgatgaaaa tgcatctgca ccaatggctg ctatgtttgg ttcatctttg gcactgtcta
    10861 tttcagatat tccatttgac ggaccaattg ctggggtaca agtgggatat gtagatggcc
    10921 aaatcatcat caacccaagt caagaacaag cagagcaatc tcttcttgaa ttgacagtag
    10981 ctggaaccaa gcacgctatc aacatggtag agtctggtgc caaagaattg tcagaagaaa
    11041 tcatgttgga agcgcttctt aaagggcacg aagctgtcaa agaattgatt gccttccaag
    11101 aagaaatcgt tgctgctgtc ggtaaagaaa aagcagaagt ggaattgctt cacgtggatg
    11161 ctgaattgca agctgaaatc attgcagcct acaacagtga cctccaaaag gcagttcaag
    11221 tagaagagaa attggcccgt gaagctgcaa ctcaagcagt gaaagaccaa gtgactgccg
    11281 tttacgaaga aaaatatgcg aaccacgaag aatttgaccg tattatgcgt gatgtggctg
    11341 aaatcttgga acaaatggaa cacgcagaag tgcgacgttt aattacagaa gacaaggtgc
    11401 gtcctgatgg tcgtaaggtc gatgaaatcc gtcctttgga tgcggttgtt gacttccttc
    11461 ctcgtgtaca tggttcaggt ctctttactc gtgggcaaac tcaagctctt tcagtcttga
    11521 ccttggctcc gatgggagaa actcaaatca ttgatggttt ggatccagag tacaagaaac
    11581 gctttatgca ccactataac ttccctcaat attctgtagg ggaaacaggt cgttacggtg
    11641 cgccaggtcg tcgtgaaatc ggtcacggtg cccttggtga gcgtgctctt gctcaagtct
    11701 tgccaagctt ggaagaattc ccatacgcta tccgtctagt agcagaagtt ttggaatcaa
    11761 acggttcttc atctcaagct tctatctgtg cgggaactct tgcccttatg gctggtggtg
    11821 tgccaatcaa ggcgccagta gctggtattg ctatgggact tatctcagat ggaaataact
    11881 acacagtatt gacagatatc caaggtttgg aagatcactt tggagatatg gacttcaagg
    11941 ttgcaggtac tcgtgatggg attacagccc ttcaaatgga tatcaagatt caagggatta
    12001 ctgcagaaat cttgacggag gctcttgctc aagccaagaa agcgcgtttt gaaatccttg
    12061 atgtcattga agcaaccatt ccagaagttc gtccagaatt ggctccaact gctccgaaaa
    12121 ttgatacgat caagattgat gtggacaaga ttaagattgt catcggtaag ggtggagaaa
    12181 ccatcgacaa gattatcgct gaaacaggtg ttaagattga tatagacgaa gaaggaaatg
    12241 tgtctatcta ctctagtgac caagatgcta ttaaccgtgc caaagaaatt attgctggtt
    12301 tggttcgtga agccaaagtg gatgaagttt accgtgctaa agtcgttcgt atcgagaaat
    12361 ttggtgcctt tgttaacctc tttgataaga cagatgccct tgttcatatc tctgagatgg
    12421 cttggactcg taccaatcgt gtagaggatt tggtagaaat cggggatgaa gttgatgtta
    12481 aggttatcaa gattgatgaa aaaggccgta tcgatgcctc tatgaaggct cttctacctc
    12541 gtccgccaaa acctgagcat gatgaaaaag gtgaaaagtc tgagcgccct caccgcccac
    12601 gtcatcacaa ggatcacaaa cctaagaaag aatttacaga aacaccaaaa gattcagaat
    12661 aagaaaagga gaaatgtatg gggtggtggc gcgaaaccat tgatatcgta aaagaaaatg
    12721 atccagcggc ccgcaccact ttggaggttt tgctgactta tccaggtgtc aaggccttgg
    12781 cggcccaccg tctctcgcat tttctctgga agcacagctt caaactctta gctcgtatgc
    12841 acagtcagtt ttggcgcttt tggactcaga ttgagattca tccaggagcc cagattgatt
    12901 caggtgtctt tattgaccat ggttctggtc tggtgattgg agagacagcg attgttgaaa
    12961 aaggcgttct tctctatcac ggagtgactc ttgggggaac agggaaagac tgtggcaaac
    13021 gccatccgac tgtacgaaag ggagccctca tatcagccca tgcccaagtt atcggacctg
    13081 tggaaattgg tgaaaatgcc aaggtcggtg ctgcagcagt tgtcgtagca gatgtaccta
    13141 gtgatgtgac ggttgtcggt attccggcca agattgtccg tcttcatggt aagaaagatg
    13201 agcctgttat tcacgaagtc gaagaaaaac gagagtatta tgtcaataaa ctcgagcagg
    13261 ctaaagatgc cagtcacaga tcgtctggtt tgtagaggat acctatatga ttcaagcaag
    13321 aaacaagtta agccaagagg agctatctga ggcgaaaaaa gtaattaact gttgccaaaa
    13381 ctatgacggt acctatcgcg atccctatct ctctaacatg cttaattttg acccaaacat
    13441 gcccgccttt ttcctttatt atgaaaaagg caaacttgtt ggtttattaa ctgtctatgc
    13501 agatgaccaa gatgtagaag tgacgatact ggttcatcca ggtcatcgcc gtcaggggat
    13561 tgcgcgtgca ttgtttacta gttttgagag agaaacagct tctttcccta ttcggtcagt
    13621 cacttttcag acagaacgta tttttttaga gaatcatcct gactttgcca gtaactgggg
    13681 actaatcgag gatgaagaga cagaaacttg gttaggtaag gatagaagac cttatccgtt
    13741 agcaaatgtt tcccatcttg aaattttgtt agcagatagt tcgtatcagg atcaaattag
    13801 tcaattaaaa tttcaggcat tttcagagga acatgaatcg agagaagttg tggatagata
    13861 tgtcgctgaa gctctgaaag atccagaaag ccgactatat attttattaa aagctggtca
    13921 ggttattggg acttgcacgg ttgatttatc gagcgatacg aattacttct acggtttagc
    13981 aatatcagaa cctgaacgtg ggaaaggcta tggaagctac ttagcaaaat cccttgtcaa
    14041 ccaactaatt gagcaaaatg ataaggaatt tcagattgca gtggaagata gcaatgtagg
    14101 tgccaaacgt ttgtatgaaa aaattggctt tgtcaaacag acacaggtgg tttatctgaa
    14161 tgagaaagga gcaagggatt ccgaagtgta gagacattcg gactgaaatt tacttgagct
    14221 cttagtttag tgatgaaact aacagttctt ggattttagc tttcctgatt atgatttatg
    14281 attaaaatct atgacaccat gtctcgtgat ttgcgagaat ttgtcccgat tgaggacggc
    14341 aagatcaaga tgtatgtttg tgggccaacg gtgtacaact atatccacgt gggaaacgcc
    14401 cgttcgacgg tagcttttga tacgattcgt cgctattttg agtaccgtgg gtataaggtt
    14461 gcctatattt ccaattttac agatgtggat gataagatta tcaaccgtgc cagggaagaa
    14521 ggcatcacgc ctcaggaggt tgcggataag tacatcgctg cctttcgtga ggatgtgacg
    14581 gccttgggcg tgaaacctgc gactcgccat ccgcgtgtag tggagtttat ggcagacatc
    14641 atccgttttg tggaagactt gatcgagaaa ggctttgcct atgagagtca aggggatgtc
    14701 tatttccgtg tagaaaaatc ccacaactat gctaaattgg ctaataaaac cttggaagat
    14761 ttggagctag gtgcttcagg tcgtaccgat gaagaaacgg ctcgtaagga aaatcctgta
    14821 gactttgctc tatggaaatc ttccaaacca ggtgagattt cttgggatag tccttgggga
    14881 cctggacgtc cgggttggca tattgagtgt tcagtcatgt cgacagagat tttaggtgat
    14941 accattgata tccacggtgg tggagctgac ctagagtttc cacaccacac caatgaaatt
    15001 gcccaatctg aagctaaaac aggcaaggct tttgctaact actggatgca caatggcttt
    15061 gtcaatatcg acaatgtcaa aatgtctaag tccttgggta acttcattac ggtacacgat
    15121 gcccttaaaa ctcttgatgg gcaagtactt cgtttcttct ttgcgaccca gcactaccgt
    15181 aagcctatca acttcacgga aaaggcagtt cgcgatgccg agaccaatct caagtatctg
    15241 aagaatactt acgaacaacc atttacagga aacgtggatg cccaagagtt acaaaacttt
    15301 aaagataagt ttgtagcagc tatggatgaa gattttaatg ctgccaacgg tatcacagtt
    15361 gtctttgaaa tggccaaatg gatcaactca gggaactatg atgcaagtgt caagcaagct
    15421 cttgcagata tgttagaaat ttttggaatt gtctttgttg aggaagtttt ggatgcagag
    15481 attgaagact tgattcaaaa acgccaagag gcgcgtgcca atcgtgactt tgcgacagca
    15541 gaccaaatcc gtgaccaatt ggttactcaa ggaattaagc tccttgatac caaggatgga
    15601 gtgaggtgga cacgtgattg atgtcaatct cattaacggg attgcgctag cctttgaggg
    15661 ggatgcggtg tattctatgt atattcgccg tcacctcatc ctcaaaggta tgaccaaacc
    15721 caataaactc catcaagaag caaccaagta tgtgtcagcc aaggctcagg ctcgcctgat
    15781 tgctctcatg ttggaggagc aggtcctaac ggaaaaagaa gaagaaatct acaaacgtgg
    15841 ccgcaatacc aatagccaca caaaggctaa aaatgcagat gtcgtgactt atcgtatgtc
    15901 cacgggattt gaagcggtta tgggctatct ccatatgact gagaatctgg aacgtcttga
    15961 gagtttggtt tcatggtgca tccaaaaagt ggagggctag aacatgaggg aaaaagaact
    16021 acaagactgg tttcctgagg ctcggatttc agaccaacca gtagagaaag agggctatct
    16081 cacgctccct ttagcttctc agcagtggat tttgctggag gaagctgggc tcagcgagcg
    16141 tgaaaagcag ttggttgccc ttttgaccca gcaggagcag gctcgttcgc taaacccttg
    16201 gtattcctat ctggttgaag gcaagggaca ggcaccgcaa gtttttaaaa agattcagtt
    16261 ggtttattgc catctttctt attttcagca ggaaaatctg gcttcttggc tagatatgat
    16321 gcggactctt tttccgaatt gtcagacagt gctacaggtc ggagttcagg attatgtttt
    16381 cgtgcttcaa caagacaaat acacttctgt aagagatatt ttaagtgata cgattgaagc
    16441 ggttgagtat gactttggac ttcgtctttc tatcatgttg ggtcaggttt ggtctcagac
    16501 aggacatcaa gccctatcag acttaatcaa agctgagcgg gatttgttca agacatggtg
    16561 gcgtcagggt caccaaggtg ttcatacttt ttctcagctc tatctttgga gtatgggaga
    16621 aagactcgtg gacttgaagc caattaaaga atgtctacac cagatgattt tggatcaaga
    16681 tcagattcag gaaatcattc tctctctttg ggaaaatagt gctgttctca ctaaaacagc
    16741 ccagcaactc tatctgcacc gcaattctct ccaatacaag attgataaat gggaagagtt
    16801 gacagggctt cagttgaaag agttgaccga cctgaccttg tgttatcaat tgattttagg
    16861 ttctttgtca actatagttg gtttgtaaag aagttaatat ttggagaaga ggattgccat
    16921 cttctccatt tttatgtgca gagttatagt ggcttgatgc tgggaaagta cactgtgact
    16981 gctaaaacat tcctagaagc tgctttgatt tccctaatct atttatgcaa attttatgtt
    17041 attttactat aacagttgtt gctaagccaa ataatagtgg ggaagttcat ttagacgtaa
    17101 gcattgaaga taatcaggga ggtagtgggc ataatttcag ttctgtttca agtagctcac
    17161 aaacagctaa atatgaagaa actggttata ataacaattc atcattatat acaacgattg
    17221 ataaaacgtc tgatgcaaca gctcttttga aattaaagtt gaataatgtt gataatcaac
    17281 ctgctactga agttcctagt tcaggaatta ctgtaaaatt aaatgctaaa gataatgctg
    17341 gaaactggac aagtgcttcg aataaaaaag aaataacagt aaaaattgtt tctgctaaac
    17401 cgacatatcc agacaaaatc ttagtgaaaa atcctgataa tataaaagat acagaaaaaa
    17461 atgccattat tgaaaaattg aaagaggcaa ataaaaatta tccagcagga gctccaacct
    17521 ttgctaaagg tgaaggagag catgcaaatg atattgtagc aacttattca gatggtacaa
    17581 cttattatgt accgttaaat gatgtgacaa aatatgcgag gtagtggctg taccactcac
    17641 ttattcacct ccccgtgatt tgtagtagtg ataggctttc tcactattat tataaaacaa
    17701 aataaagagc acaacacttt ttcattctgt gttgtgcctt gagtgaaacg aaaggaatga
    17761 attataaata tgaaaagtat agtcactagc atagatgagc gcttgcgtac tcgcctacga
    17821 gtgattatct ggaagcaatg gaagaagaaa tcgagacgat tatggggatt gcttaagtta
    17881 ggggttccta aatggatagc agataaggta tctggctgga gcgaccacta tcaattatag
    17941 taaaatgaaa taagagtagg acgaatcgat cagggcagcc aaatcgattt ctaacaatgt
    18001 tttagaagaa gagatgtact attctagttt caatctacta tagtagctca gaagtcggta
    18061 cttaaacgtg ctatatcaaa accagtcctt gaaaaacgtg aaca
//
LOCUS       DAVHSO010000047        17506 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.047, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000047 DAVHSO010000000
VERSION     DAVHSO010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 17506)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17506)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17506
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.047"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(26..961)
                     /locus_tag="VVR18_001562"
     CDS             complement(26..961)
                     /locus_tag="VVR18_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional biotin--[acetyl-CoA-carboxylase]
                     synthetase/biotin operon repressor"
                     /protein_id="HEU6033060.1"
                     /translation="MKSYQAVYQILSKETDYISGEKIAEKLSLSRTAIWKAIKRLEQE
                     GIEIDSIKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEANT
                     LYLASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVAGAVYKAIKNL
                     TLIDVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDIIIGVGINFTIKDFPQELKE
                     KAASLFKATAPITRNELIIEIWRAFFETPAEELLYLYKKQSFILGKEVTFTLEQKDYK
                     GLAKDISENGKLLVQCDNGKEIWLNSGEISLNSWK"
     gene            complement(958..1818)
                     /locus_tag="VVR18_001563"
     CDS             complement(958..1818)
                     /locus_tag="VVR18_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEU6033061.1"
                     /translation="MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYIT
                     KGQGKFHYKGKIVDLKEGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKAPDYFALS
                     QISDQSYLIKSETCHTQTTAKLISDIVRFAQITKSSELAQLHIMGQLHELMFHLGTIA
                     PNQKKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSP
                     KEYLLYVRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQTPSHTRKEYS
                     QYQLVRKATL"
     gene            1926..4088
                     /locus_tag="VVR18_001564"
     CDS             1926..4088
                     /locus_tag="VVR18_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000538915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="HEU6033062.1"
                     /translation="MGVRIENNLFYVESKNLSLIIENRNGYLLLKHLGKTIKNYKGSN
                     SVYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHNVTEVTDFRFVE
                     AKILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLD
                     NNSNQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGAS
                     GHAQTPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSW
                     KLAPEEYFETPVALVTHSDQGLTGISHESQNFVLKHIMLSEFSKKERPILINNWEATY
                     FDFQREKLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLI
                     SAIHERGLQFGLWLEPEMISVDSDLYRQHPDWAIQVPGYEHTYSRNQLVLNLANPQVV
                     EYLKSVLDQLLSYHDIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLT
                     EKHSHILFESCSGGGGRNDLGMMRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGA
                     HVSAVPNHQMGRMTPLETRGHVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPV
                     VQLGQQYRLINPDTASNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLY
                     ELQENGEVYSGAELMYAGLTVILSQGDFLSRQYIFRRL"
     gene            4123..5382
                     /locus_tag="VVR18_001565"
     CDS             4123..5382
                     /locus_tag="VVR18_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU6033063.1"
                     /translation="MEWYKKIGLLATTGLALVGLGACSNYGKSADGTVTIEYFNQKKE
                     MTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEW
                     AKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKV
                     PETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQ
                     PNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAI
                     TAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPE
                     VMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTM
                     NYVLTGDKQGMVNDLNAFFNPMKADVD"
     gene            5396..6262
                     /locus_tag="VVR18_001566"
     CDS             5396..6262
                     /locus_tag="VVR18_001566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6033064.1"
                     /translation="MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLT
                     YNYKFVGLNNFKLLFMDPKFMNAIGFTAIITIAMVVGEIALGIFIARVLNSKIKGQTF
                     FRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFLQTSLLGTKWGAIFAAVFV
                     LLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSIVFILA
                     LKGGLTAFDQVFAMTGGGPNNATTSLGLLVYNYAFKNNQFGYANAIAVILFFLIVVIS
                     IIQLRVSKKFEI"
     gene            6276..7109
                     /locus_tag="VVR18_001567"
     CDS             6276..7109
                     /locus_tag="VVR18_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU6033065.1"
                     /translation="MKQDERKALIGKYILLILGSVLILVPLLATLFSSFKSTKDIVDN
                     FFGFPTNFTWDNFSRLLADGIGGYYWNSVVITVLSLLAVMIFIPMAAYSIARNMSKRK
                     AFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGY
                     IKISIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVL
                     NRDSKMWTLPLFQYNYAGQYFNDYGPSFASYVVGIISITIVYLFFQRHIIAGISNGAV
                     K"
     gene            7110..7190
                     /locus_tag="VVR18_001568"
                     /pseudo
     CDS             7110..7190
                     /locus_tag="VVR18_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            7328..8770
                     /gene="gtfA"
                     /locus_tag="VVR18_001569"
     CDS             7328..8770
                     /gene="gtfA"
                     /locus_tag="VVR18_001569"
                     /EC_number="2.4.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose phosphorylase"
                     /protein_id="HEU6033066.1"
                     /translation="MPIQNKTMLITYSDSLGNNLKDLYDNLEEHFGDAIGGVHLLPFF
                     PSTGDRGFAPVDYDEVDSAFGDWEDVKRLGEKYYLMFDFMINHISRQSKYYKDYQEKH
                     EASEFKDLFLNWDKFWPENRPTQSDVDLIYKRKDRAPKQEIVFEDGSVEHLWNTFGEE
                     QIDLDVTKEVTMEFIRKTIQHLASNGCDLIRLDAFAYAVKKLDTNDFFVEPDIWDLLD
                     KVRDIAAEYGTEILPEIHEHYSIQFKIADHDYYVYDFTLPMVTLYTLYSSRTERLAKW
                     LKMSPMKQFTTLDTHDGIGVVDVKDILTDEEIDYASNELYKVGANVKRKYSSAEYNNL
                     DIYQINSTYYSALGDDDVKYFLARLIQAFAPGIPQVYYVGLLAGKNDLKLLEETKEGR
                     NINRHYYSNEEIAKEVQRPVVKALLNLFSFRNRSEAFDLEGTTEIETPTAHSIVIKRQ
                     NKDKSVTAVAEIDLQNQTYRVIENGVEVSF"
     gene            8908..10101
                     /locus_tag="VVR18_001570"
     CDS             8908..10101
                     /locus_tag="VVR18_001570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008293041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen ligase family protein"
                     /protein_id="HEU6033067.1"
                     /translation="MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIIS
                     LIFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQS
                     ILSHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFF
                     NPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAG
                     AIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMAL
                     FKQNPFWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRL
                     MMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLV
                     SDMTD"
     gene            10787..12766
                     /locus_tag="VVR18_001571"
     CDS             10787..12766
                     /locus_tag="VVR18_001571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000742236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6033068.1"
                     /translation="MKKNRVFATAGLVLLAAGVLAACSSSKSSDSSAPKAYGYVYTAD
                     PETLDYLISSKNSTTVVTSNGIDGLFTNDNYGNLAPAVAEDWEVSKDGLTYTYKIRKG
                     VKWFTSDGEEYAEVTAKDFVNGLKHAADKKSEAMYLAENSVKGLADYLSGTSTDFSTV
                     GVKAVDDYTLQYTLNQPEPFWNSKLTYSIFWPLNEEFETSKGSDFAKPTDPTSLLYNG
                     PFLLKGLTAKSSVEFVKNEQYWDKENVHLDTINLAYYDGSDQESLERNFTSGAYSYAR
                     LYPTSSNYSKVAEEYKDNIYYTQSGSGIAGLGVNIDRQSYNYTSKTTDSEKVATKKAL
                     LNKDFRQALNFALDRSAYSAQINGKDGAALAVRNLFVKPDFVSAGEKTFGDLVAAQLP
                     AYGDEWKGVNLADGQDGLFNADKAKAEFAKAKKALEADGVQFPIHLDVPVDQASKNYI
                     SRIQSFKQSVETVLGVENVVVDIQQMTSDEFLNITYYAANASSEDWDVSGGVSWGPDY
                     QDPSTYLDILKTTSSETTKTYLGFDNPNSPSVVQVGLKEYDKLVDEAAKETSDLNVRY
                     EKYAAAQAWLTDSSLFIPAMASSGAAPVLSRIVPFTGASAQTGSKGSDVYFKYLKLQD
                     KVVTKEEYEKAREKWLKEKAESNEKAQKELASHVK"
     gene            12833..14329
                     /locus_tag="VVR18_001572"
     CDS             12833..14329
                     /locus_tag="VVR18_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033069.1"
                     /translation="MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYN
                     KIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYI
                     NQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYL
                     RFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVIT
                     QGQGQTKTAQVQFPTGKKTSSVNIYSRTYKSPSQADSREVASYGKDDPYTATESNYQY
                     PSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGTLTFLLALPTIALVY
                     IVRLIGSSIALPDSFPILGAGDWRSYVLPAVILGLLGAPVTAIWIRRYMIDLQSQDFV
                     RFARAKGLSEKEISNKHIFKNAMVPLVSGIPGAIIGVIGGATLTETVFAFPGMGKMLI
                     DSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK"
     gene            14329..15255
                     /locus_tag="VVR18_001573"
     CDS             14329..15255
                     /locus_tag="VVR18_001573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033070.1"
                     /translation="MSTIDKEKFQFVKRDDFASETIDAPAYSYWKSVFKQFMKKKSTV
                     VMLGILVAIILISFIYPMFSKFDFNDVSKVNDFSVRYIKPNAEHWFGTDSNGKSLFDG
                     VWFGARNSILISVIATVINLVIGVFVGGIWGISKSVDRVMMEVYNVISNIPPLLIVIV
                     LTYSIGAGFWNLIFAMSVTTWIGIAFMIRVQILRYRDLEYNLASRTLGTPTLKIVAKN
                     IMPQLVSVIVTTMTQMLPSFISYEAFLSFFGLGLPITVPSLGRLISDYSQNVTTNAYL
                     FWIPLTTLVLVSLSLFVVGQNLADASDPRTHR"
     gene            15264..16331
                     /locus_tag="VVR18_001574"
     CDS             15264..16331
                     /locus_tag="VVR18_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033071.1"
                     /translation="MTKEKNVILTARDIVVEFDVRDKVLTAIRGVSLELVEGEVLALV
                     GESGSGKSVLTKTFTGMLEENGRIAQGSIDYRGQDLTALSSHKDWEQIRGAKIATIFQ
                     DPMTSLDPIKTIGSQITEVIVKHQGKTAKEAKELAIDYMNKVGIPDADRRFNEYPFQY
                     SGGMRQRIVIAIALACRPDVLICDEPTTALDVTIQAQIIDLLKSLQNEYHFTTIFITH
                     DLGVVASIADKVAVMYAGEIVEYGTVEEVFYDPCHPYTWSLLSSLPQLADDKGDLYSI
                     PGTPPSLYTDLKGDAFALRSDYAMQIDFEQKAPQFSVSETHWAKTWLLHEDAPKVEKP
                     AVIANLHDKIREKMGFAHLAD"
     gene            16342..17268
                     /locus_tag="VVR18_001575"
     CDS             16342..17268
                     /locus_tag="VVR18_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033072.1"
                     /translation="MSEKLVEIKDLEISFGEGSKKFVAVKNANFFINKGETFSLVGES
                     GSGKTTIGRAIIGLNDTSNGDIIFDGQKINGKKSREQAAELIRRIQMIFQDPAASLNE
                     RATVDYIISEGLYNHRLFKDEEERKEKVQNIIREVGLLAEHLTRYPHEFSGGQRQRIG
                     IARALVMQPDFVIADEPISALDVSVRAQVLNLLKKFQKELGLTYLFIAHDLSVVRFIS
                     DRIAVIYKGVIVEVAETEELFNNPIHPYTQALLSAVPIPDPILERKKVLKVYDPSQHD
                     YETDKPSMVEIRPGHYVWANQAELARYQKGLN"
BASE COUNT         5136 a         3139 c         3690 g         5541 t
ORIGIN      
        1 tcgtttatat tataattgtg ttattttact tccaactatt gagagaaatt tcgccactat
       61 ttagccagat ttcttttccg ttatcacatt gaactaaaag ttttccattt tctgagatgt
      121 ctttagcaag tcccttgtag tctttttgct ctagtgtgaa agtgacttct tttcctagaa
      181 tgaatgactg ttttttgtat aggtataata gctcttctgc tggtgtttcg aagaaagcac
      241 gccagatttc tatgatcaat tcattccttg ttataggagc tgtagcttta aataagctgg
      301 cagctttttc ttttaattcc tgagggaagt ctttaatagt gaaattgata cctactccaa
      361 taatgatatc tgtgactaag ccagtttcta cagaggtcat tgcttcagta aggattcctc
      421 caattttatg attgtttaga tagatatcat tgacccattt tatgtcgaca tctattaaag
      481 ttaggttctt aatggctttg tagacagctc cagctacaag tagtgtgtag gatggtaatt
      541 tgtcataggg gagatttggt ttaagatgga gtgtcatata aataccacct tgtggtgagt
      601 agaaggaacg ttgaaaacgg cctcggcctg ctgtttgata ggaagctaga tagagggtat
      661 ttgcttcatg gcctaaatca attgcttctt ttgcatctag ttgtgttgat tttgtttcgg
      721 gtttaaagct gactttaatt ggaagatttt cttctagaat ctctggaaga ataaggtcac
      781 cattcatcag tttatatcct ctatttttga tactatcaat ttcaatgcct tcttgttcta
      841 gtcgcttgat ggctttccaa attgctgttc ggcttaggga tagtttttct gcgatttttt
      901 ctccgctgat atagtcggtt tctttagata ggatttggta gacagcttgg taggatttca
      961 taatgttgcc tttcttacta gttggtattg agagtattct tttcttgtat gacttggagt
     1021 ctgattaaag tattgtttat aagctttcga aaaatggagt ggatctgaaa aacctaccga
     1081 gtatgcaatt accttgatgg actcttgggt attttcgaga agttgtctag ctcggtgcat
     1141 tcgaacgtag agtaggtatt ctttgggtga taaggtatta aattctttga atacgcttga
     1201 taagtagctt ctgtgaacgg atagttcttt tgctaaatct tgaattgtaa gtgattgagg
     1261 atagtggcta tcaattaatc gtttgcattc aagatagagt tggtgggttg atgaaatatt
     1321 cttttttttc tgattgggag caatagttcc cagatgaaac atcagttcat gaagttgtcc
     1381 catgatatgg agttgagcta attcacttga ttttgtaatc tgagcgaagc ggacaatgtc
     1441 tgagatgagt tttgcagtag tctgggtatg acaagtttca gatttgatga gataggattg
     1501 atcagaaatt tgggaaagag caaaataatc aggggctttc cctccagtga ttcctaacca
     1561 gtagtaggcc caaggttctt tactatctgc ttgataaaag gttagttcct ctggttttaa
     1621 tagaaagaaa tctccttctt ttaaatcaac aattttaccc ttgtaatgaa attttccttg
     1681 tcctttagta atgtaatgta ggacgtatgt atcacgaatg gctggaccaa aagagtaatt
     1741 aggtgtgcat tcctcatatc cataaaagct tagggcaagg tcgattgttc cagtctggta
     1801 ttctgaaaaa actaacatgt gctatctcct acctaacatt ttaccatatt cttgagacat
     1861 ttttctattt tagaaagcga tttcaggtga taaaatagag tcaataaagt gatgaggtga
     1921 agtaaatggg agttaggata gagaataatc tattttatgt tgagagtaaa aatctaagtt
     1981 tgattattga aaatcgaaat ggctacttac ttttgaaaca tttaggaaag actattaaga
     2041 actataaagg ttccaatagt gtttatgaac gagaccatgc cttttcagga aatccaacag
     2101 ctactaatcg aacctttagt ttagatactc aacgtcaaat ttttggacaa catggcttag
     2161 gagattttag gaaaccaacc atacaggttc agcataatgt aactgaagta acagactttc
     2221 gatttgtaga agcaaagatt ttaaaaggtc agaatggtcc acagggctta ccttctccac
     2281 atagcatgga cgatacagag actcttgtct taatgttaga agattctaag gctcaactta
     2341 gtctgacttt gtattatact acttttaata atgatgcgac tattgctagc tacagtaaat
     2401 tagataataa tagtaatcag gaagttgtca tccataaaga tttttctttt atggctgatt
     2461 ttccagctgc agattacgaa atagtaactc tgcagggtgc ttatgctcgt gaaaagactg
     2521 ttagacgtca acaggtagaa caaggaatct tttcgattag ttcaaaccga ggtgcttctg
     2581 gtcatgctca aacaccagct cttctactat gcgaacaagg agtcacagag gatgctggga
     2641 atgtgtttgc tattcaacta atgtatagtg gcaactttga agcttttgtt caaaaaaatc
     2701 aattgaatga agttcgggtg gctattggca ttaatccaga aaacttttct tggaagttag
     2761 cccctgagga atactttgaa acaccggtag ctttagtgac tcattcagat cagggattaa
     2821 ctggtattag tcatgaaagt cagaattttg tactgaagca cattatgcta agtgaatttt
     2881 ctaaaaaaga acgtccaatt ctaatcaata actgggaagc tacttacttt gactttcaga
     2941 gagaaaaact gttagagtta gcagatgaag ctaagaaagt tggcattgaa ctttttgtat
     3001 tagatgatgg ttggtttggc aatcgttttg atgataatcg tgctttaggt gattgggttg
     3061 ttaatgagga aaaactgggt ggaagtctag aaagtctgat ttcagctatc catgaaagag
     3121 gtttgcagtt tggactttgg ttagaacccg aaatgatttc tgtagatagt gatttgtatc
     3181 gtcaacatcc tgactgggct attcaggttc ctggctatga gcatacttat tctcggaatc
     3241 aattagtact taatcttgcc aatcctcagg tagtagaata cttgaaaagt gtcttagatc
     3301 aactcctatc ttatcatgat attgattaca ttaaatggga tatgaaccgc aatatcacta
     3361 agctagggaa tggattaact tatctagaga cacagatgca atctcatcag tacatgctgg
     3421 ggctttacga actcgtttct tatctgacag agaagcacag ccatattctc tttgagtcct
     3481 gctctggtgg tggtggacga aatgatcttg gtatgatgcg ctatttccca caagtctggg
     3541 ctagtgataa tactgatgcc attgcacgtt taccaattca atacggttca tcctatctct
     3601 atccaaccat ttctatgggg gctcatgtgt cagcagtacc gaatcatcag atgggacgaa
     3661 tgacaccatt agaaacacgt ggccatgtag caatgatggg aaatttgggc tatgagcttg
     3721 atttgacaaa tttatcagat gaagagaaag ctacgattgc taatcaggtg aacttgtata
     3781 aagaattacg accagtagtt cagttaggac agcagtatag actaattaat cctgatactg
     3841 catccaatga agcagctgta caatttaatt acggaaatca aacgattgta acctacgttc
     3901 gcgttttatc tgttgtagag accatggaaa caactttaaa attaaaagat ttggatgaag
     3961 agggactata tgaattacag gaaaatggcg aagtttactc aggtgcagaa ctaatgtatg
     4021 cgggcctaac tgttatctta tcccaaggag attttttgag tagacagtat atttttagaa
     4081 gactatgata agggtgtata aatttataaa ggaggctttc taatggaatg gtataaaaaa
     4141 atcggacttc ttgcaactac aggtttagct ttggttgggc tcggcgcttg ctccaactat
     4201 ggtaaatctg cggatggcac agtgaccatc gagtatttca accagaaaaa agaaatgacc
     4261 aaaaccttgg aagaaatcac tcgtgatttt gagaaggaaa accctaagat caaggtcaaa
     4321 gtcgtcaatg taccaaatgc tggtgaagta ttgaagacac gcgttctcgc aggagatgtg
     4381 cctgatgtgg tcaatattta cccacagtcc atcgaactgc aagaatgggc aaaagcaggt
     4441 gtctttgaag atttgagcaa caaagactac ctgaaacgcg tgaaaaatgg ctacgctgaa
     4501 aaatatgctg taaacgaaaa agtttacaac gttcctttta cagctaatgc ttatggaatt
     4561 tactacaaca aagataaatt cgaagaactg ggcttgaagg ttcctgaaac ctgggatgaa
     4621 tttgaacagt tagtcaaaga tatcgttgct aaaggacaaa caccatttgg aattgcaggt
     4681 gcagatgctt ggacactcaa tggttacaat caattagcct ttgcgacagc aacaggtgga
     4741 ggaaaagaag caaatcaata ccttcgttat tctcaaccaa atgccattaa attgtcggat
     4801 ccgattatga aagatgatat caaggtcatg gacatccttc gcatcaatgg ctctaagcaa
     4861 aagaactggg aaggtgctgg ctataccgat gttatcggag ccttcgcacg tggggatgtc
     4921 ctcatgacac caaatgggtc ttgggcgatc acagcgatta atgaacaaaa accgaacttt
     4981 aagattggga ccttcatgat tccaggaaaa gaaaaaggac aaagcttaac cgttggtgcg
     5041 ggagacttgg catggtctat ctcagccacc accaaacatc caaaagaagc caatgccttt
     5101 gtggaatata tgacccgtcc agaagtcatg caaaaatact acgatgtgga cggatctcca
     5161 acagcgatcg aaggggtcaa acaagcagga gaagattcac cgcttgctgg tatgaccgaa
     5221 tatgccttta cggatcgtca cttggtctgg ttgcaacaat actggaccag tgaagcagac
     5281 ttccatacct tgaccatgaa ctatgtcttg accggtgata aacaaggcat ggtcaatgat
     5341 ttgaatgcct tctttaaccc gatgaaagcg gatgtggatt aggagtagag agactatgaa
     5401 aaaagtatta caaaaatatt gggcatgggc ttttgtggtc atccccctct tgttacaagc
     5461 aattttcttc tatgtgccga tgtttcaagg agccttttac agttttacca actggacagg
     5521 attgacttac aactacaaat ttgtcggctt aaacaacttt aagctcctct tcatggatcc
     5581 aaaattcatg aatgcgattg gctttaccgc aatcattacg attgccatgg tggttggtga
     5641 gattgcactc gggatcttca ttgcgcgtgt cttgaactct aaaatcaaag gccaaacctt
     5701 cttccgtgct tggttcttct tcccagctgt tttatctggt ttgacagtgg ctttgatctt
     5761 caagcaagtc ttcaactacg gtcttccagc gattgggaat gcccttcata ttgaatttct
     5821 ccaaaccagt cttttaggga ctaagtgggg agcaatcttt gcggctgtct ttgtccttct
     5881 ttggcaaggg gtggctatgc ccatcatcat cttcctagct ggtttgcaat ctattccaac
     5941 tgagattaca gaggcagcaa ggattgatgg tgcgactagc aagcaagttt tctggaacat
     6001 tgaattgcct tacttgctac caagtgtctc tatagtcttt atcctagccc taaaaggtgg
     6061 gctgactgcc tttgaccaag tctttgccat gaccggtggt ggtccaaaca atgccacaac
     6121 ctcacttggg ctcttggttt ataactatgc ctttaaaaac aaccaattcg gttatgccaa
     6181 tgccattgcc gtaatcttgt tcttcttaat tgtagtgatt tcgatcatcc aattgagagt
     6241 atctaagaaa tttgaaattt aagaggagaa gcatgatgaa acaagatgaa agaaaagccc
     6301 tgattggcaa atacattcta ttgattctag gatcggttct gattttagtg ccgctccttg
     6361 ctaccctctt tagttccttc aaatccacta aggatattgt agataatttc tttggctttc
     6421 caaccaactt cacatgggac aactttagcc gtctcttagc tgatgggatt ggaggctatt
     6481 attggaactc tgtcgtcatc actgtcttgt ctttacttgc agtaatgatc tttatcccta
     6541 tggcagccta ctccatcgct cgcaatatga gtaaaagaaa agcctttacc atcatgtata
     6601 ccctcttaat cctcggaatc ttcgtacctt tccaagtcat catgattccg attacggtta
     6661 tgatgagtaa actcggtttg gctaatacct ttggtttgat cttgctctac ttgacctatg
     6721 cgattccaca gaccctcttt ctctatgttg gctatatcaa aatctcgatt ccagaaagtc
     6781 tggatgaagc agcagagatc gatggggcta atcaatttac aacctatttc cgcatcatct
     6841 tcccaatgat gaaaccgatg catgcgacaa ccatgatcat caatgccctt tggttctgga
     6901 atgacttcat gttgccactc cttgtcttga accgggattc caaaatgtgg actctgcctt
     6961 tgttccaata caactacgca ggccaatatt tcaacgacta cggaccaagc tttgcctctt
     7021 acgtggtcgg cattatcagt atcaccattg tctatctctt cttccaacgc catatcatcg
     7081 caggaataag caacggggca gtgaagtaat actcaatgaa aatcaaagag caaactagga
     7141 agctagccgc aggttgctca aaacactgtt ttgaggttgt ggatgaaact gacgaagtca
     7201 gtaaccatac ctacggtaag gcgacactga cgtggtttga agagattttc gaagagtata
     7261 acatgaattt gatttacgaa gccagatcat atgagacttg gcttcaatta gaaaaaggag
     7321 agtaatgatg ccaattcaaa ataaaaccat gttgattacc tattctgata gccttggaaa
     7381 taatcttaaa gacttatatg ataatttgga agagcatttt ggagatgcta ttggaggagt
     7441 tcacctttta ccatttttcc catcaacagg tgatcgtgga tttgcgccag ttgactacga
     7501 cgaagtggac tcagcttttg gtgattggga ggatgttaag cgtttaggtg agaaatatta
     7561 tcttatgttt gattttatga ttaatcatat ttctcgtcaa tccaagtatt ataaggacta
     7621 tcaagaaaaa catgaagcca gtgaatttaa agatctcttt ttaaactggg ataagttttg
     7681 gccagaaaac cgtccgacac agtctgatgt agatttaatt tacaagcgta aggatcgtgc
     7741 accaaagcaa gagattgtgt ttgaagatgg ttcagtggaa catttgtgga atacctttgg
     7801 tgaggagcag attgatcttg atgtgaccaa agaagtaact atggaattta tccgtaagac
     7861 cattcagcac ttggcaagta atgggtgtga tttgattcgt ctagatgcct ttgcttatgc
     7921 agtgaagaaa ttggatacta atgatttctt tgtggaacca gatatttggg atttattgga
     7981 caaagttcga gatatcgctg ctgagtatgg gacagagatt ttacctgaga ttcatgaaca
     8041 ctattcgatt cagtttaaaa tagcagacca tgattactat gtttatgatt ttactcttcc
     8101 aatggtgaca ctttatactc tttacagttc cagaacagag cgtttggcta agtggttgaa
     8161 gatgagcccg atgaagcaat ttacgacgct agatacccat gatgggattg gagtagtaga
     8221 tgtcaaggat atcctgaccg atgaggagat tgactatgct tcaaatgaac tctataaggt
     8281 tggagccaat gtcaaacgta agtactctag tgccgagtat aacaacttag atatctacca
     8341 aatcaattca acctactatt cagcgcttgg agatgatgat gtcaagtatt ttctcgctcg
     8401 tctaattcaa gcttttgccc caggtattcc tcaggtttac tatgtgggtc tattagcagg
     8461 caagaatgac ttgaaattat tagaagaaac taaagaaggt cgaaatatta atcgtcatta
     8521 ctatagcaac gaggaaatag caaaagaagt gcaacgacct gttgtgaagg cccttctcaa
     8581 tctattttct ttccgtaacc gttcagaagc ctttgatcta gaagggacta ctgagataga
     8641 gacaccaaca gctcacagca ttgtaatcaa acgtcaaaat aaagataagt ccgtaacagc
     8701 agtagcagaa attgatttgc aaaatcagac ttatcgggta attgagaatg gagttgaagt
     8761 atcattttga agccttgata tggtggataa aatagggttt ttattttgga aaacgtttcc
     8821 tttgttttca aattgctaaa aaagtggtac aatataggat agcttactat tatctgaatc
     8881 agctgatttg gagagaaagg attcattttg aaatcaatag gctttattga aaagctgaag
     8941 gggttgtcta gtaaagagct gattttattg ggaattatcc taagtatctt tttacccttt
     9001 tatctttttg tagttgtact ctgtttatat attatcagtt tgatttttac aggagacatg
     9061 aaaagtattc ttcagaaaat gggggagcat ccgatgctgc ttctttttct tagctatagt
     9121 actgttatat ccattcttgc acaaaattgg atgggtcttg tggcttcagt aggaatgttt
     9181 ctatttacta ttttcttttt gcactatcag tcgattttat cccataaatt ctttcgattg
     9241 attttgcagt tcgtcttgtt tggtagtgtc ttgtcagctg cttttgccag tttagaacat
     9301 ttccaaattg tgaagaaatt taactatgct tttctttcac ccaatatgca ggtgtggcat
     9361 cagaaccggg cagaagtgac cttctttaat cctaattatt atggaattat ttgttgtttc
     9421 tgtattatga ttgctttcta tctgtttaca acgaccaagt tgaattggtt gaaagtattc
     9481 tgtgtgattg caggctttgt taatctcttt ggtttgaact ttactcaaaa tcgaactgcc
     9541 tttcctgcta ttatcgctgg agcaattatc tatctcttta cgactattaa aaactggaag
     9601 gccttttggc ttagtattgg ggtcttcgcg attggtttga gtttcctctt ttctagtgat
     9661 ttgggagttc gaatgggtac tttagactct tctatggaag aacgcatttc tatctgggat
     9721 gctgggatgg ccttgtttaa gcaaaatcct ttttggggtg aagggccatt gacctatatg
     9781 cactcttatc ctcggataca tgctccttat catgaacatg cccacagtct ttatattgat
     9841 acgattctga gttacggaat tgtgggtacc attttattag ttttgtcttc tgttgctcct
     9901 gttcgcttga tgatggatat gagtcaggag tcggggaaac gtccgattat cggcctttat
     9961 ctatctttcc ttacagtggt tgctgtgcac ggaatttttg acttggctct cttctggatt
    10021 cagtcaggct ttattttctt gctagttatg tgcagtattc cattggagca tcgaatgttg
    10081 gtatcggaca tgacggatta agttttataa gtttgaaatc ttctaccttg ggtaggagat
    10141 ttttttatac gatgggcatg tcgtgcatct gaggtgtaag tcctctgtag ggatccacta
    10201 ccggtgaata caatagcgct ccccaagcct gactatcgtg aggtagcgga ttaaaatggt
    10261 ctggggatag atcgttttaa gtctgacgca ggaaataaga attgtcagag aaagcaatag
    10321 tgaaatcgta ggctatgaat agaaacgtga tagcgaggag catatagtgg ataaggtagc
    10381 gagaaatttt aaagtataaa agatagtctt aatctatata tgtaaatcac aaaagtaatt
    10441 gaattcggaa taaggttggt gtgaaaagac atagtaaact gaatcttgaa tactagaatg
    10501 atacttctac aatattgtta taatttaatt tgaattccaa aatcacattg ttccgtccgt
    10561 atttcatttt actgtatgtc ttcctaaact ccaaagtttc tgcgtcaaat ttcctatttt
    10621 cactgtagtc tttgacactt cgaacgacaa tttgaatcat atattcaaaa aaaatgaaaa
    10681 atttgtgcca acaagcctaa atattctgaa aatttgtttg atttttaatg gataatgtga
    10741 tataatggtt gtcaatctat aattcacata aacagaggag tagaaaatga aaaaaaatcg
    10801 tgtatttgct acagcaggtc ttgttttatt agcagcaggt gtacttgcag catgcagttc
    10861 ttcaaaatca tctgattcat cagcccctaa agcttatggc tatgtttata cagcagaccc
    10921 agaaaccttg gactacctga tttcaagtaa aaatagtaca acagtagtga cttcaaatgg
    10981 gattgatggt ttattcacta acgataatta cggtaatctt gctcctgcag ttgcagagga
    11041 ttgggaagtc tctaaggatg gtttgaccta cacttataag attcgtaaag gggttaaatg
    11101 gtttacctct gatggagaag aatatgcaga ggtgacggct aaagatttcg tgaacggttt
    11161 aaaacacgca gcagataaaa aatcagaagc tatgtattta gctgaaaatt cggttaaagg
    11221 cttggcagat tatctatcag gaacttcaac agatttttca acagttggtg tcaaggcggt
    11281 tgatgattat acgttacaat acactttgaa ccagcctgaa ccgttctgga actctaagtt
    11341 gacctattct attttctggc ctctgaatga agaattcgaa acatcaaaag gaagcgattt
    11401 tgctaaacca acagatccga catccttgct ttataatggt ccattcttgt tgaaagggtt
    11461 gactgcaaaa tcttctgtag agtttgtaaa aaatgagcaa tattgggata aagaaaatgt
    11521 ccacctagat actatcaatc tagcttacta tgatggatca gatcaggagt cgctagagcg
    11581 taacttcact agtggagctt atagttatgc ccgtctttac cctaccagct ccaactattc
    11641 taaggttgca gaagaataca aggacaatat ctattacaca caatcaggct ctgggattgc
    11701 tggtctgggt gtgaatattg atcgccaaag ttacaactat acttctaaaa ctacagattc
    11761 agagaaagta gctactaaga aggcattgct taacaaagat ttccgtcaag ccttgaattt
    11821 tgctcttgat cgctcagctt actcagctca aatcaatggt aaagatggag cagctttagc
    11881 agttcgtaat ttatttgtaa aaccagactt tgtttcagct ggtgagaaga cctttggtga
    11941 tttagtcgct gctcaacttc ctgcttatgg tgatgagtgg aaaggtgtga atttagctga
    12001 tgggcaggat ggtttattca atgctgacaa ggccaaggca gagtttgcga aagctaagaa
    12061 agctttagaa gcagacggcg ttcagtttcc tattcatctg gacgttccag tagaccaagc
    12121 atcaaaaaac tacatatctc gtattcagtc ctttaaacaa tctgtagaaa cagttcttgg
    12181 tgttgaaaat gtcgttgttg atattcaaca aatgacaagt gatgaattcc ttaatattac
    12241 ttactatgct gccaatgctt catctgagga ttgggatgta tcgggaggag tttcatgggg
    12301 gccagactat caagacccat ctacttacct ggatatttta aaaacaacta gcagtgaaac
    12361 tacaaaaaca tatttaggat ttgataatcc aaatagccct tcagtagttc aagttggttt
    12421 gaaagaatac gataaattag ttgatgaagc tgccaaagag acaagcgact tgaatgtccg
    12481 ttatgaaaaa tatgcagcgg ctcaagcatg gttgacagat agttcactct ttattcctgc
    12541 tatggcttct tctggtgcag caccagtgct ttcacgaatt gttccattta ctggagcttc
    12601 tgcgcaaaca ggctctaagg ggtcagatgt ttacttcaaa tatttgaaat tacaagataa
    12661 agtggtgact aaggaagagt atgaaaaagc tcgtgaaaaa tggttgaaag aaaaagctga
    12721 atcaaatgag aaagctcaaa aagaattggc aagtcatgtg aagtaaataa tttctaatag
    12781 aactttctct ccatgaggag aaggttcttt tgggattttt aaaggaaata atatgaaaaa
    12841 atatattttt atgcgtgttt tgcggtcatt ggtttcgatt ttcttagtaa cgactttgac
    12901 ctacacgatt atctatacct tggttcctcg aaaattgatt ttcaagcagg atcctaacta
    12961 taataaaatt gcgacaacgg ctgataaacg tgataactat gaaaatactg tgtttgagcg
    13021 tatgggctac attgagtatt acgatactaa agagttgcaa gaaaaggcaa gtagcatgga
    13081 ttcttctgta acagtagaag caaatgcgac caataaagct atttatgaaa agtacatcaa
    13141 tcaattaggt catggttgga ctttgggaga atttactgaa agtggtcaat tctatgctac
    13201 tcgtgaaatt ccaatttttg aacgtgtttt tcacttctat gctaacttga ttgacattga
    13261 ccatacaaat aaaatccaag accctgaaaa tccagacttg aaacgctacc ttcgttttga
    13321 aaatgatcca gctatcggat ggtcattggt cggttcagga actaaacata aatatctctt
    13381 gtactttaac agtcagttcc catttgttca tcaaaacttt gtgaacttga atttaggtga
    13441 ctcttaccca acctatgcta atacaccagt tcttcaggtt attactcaag gtcaaggaca
    13501 aaccaaaact gcccaagttc agttcccaac aggtaagaaa acgtcttctg taaatattta
    13561 ctcaagaacc tacaagtcac ctagtcaggc tgactctcgt gaagtagcta gctatgggaa
    13621 agatgatcct tatacagcga ctgaaagtaa ttaccaatat ccatctatga ttgtcagctc
    13681 tgctattact ggtttgattg gtttggttct tgcctatgct cttgccgtgc cacttggttc
    13741 agccatggct cgtttcaaga acacttggat tgatagcctc tcaacaggga ctttgacctt
    13801 cttgcttgct cttccaacga ttgccttggt ttacatcgtt cgattgattg gatcatctat
    13861 tgcccttcca gattcattcc ctatcttggg agctggagat tggcgttctt acgttttacc
    13921 agcagtcatc cttggtttgt tgggtgctcc tgttacagcc atttggattc gtcgttacat
    13981 gattgacttg caatctcaag actttgttcg tttcgctcgt gcaaaaggtt tgtctgaaaa
    14041 agaaatttca aacaaacaca tctttaaaaa tgccatggtt ccgctggttt caggaattcc
    14101 tggtgccatt attggggtta tcggtggtgc aacccttact gaaacagtct tcgccttccc
    14161 aggtatgggt aaaatgttga ttgactctgt aaaagcatct aataactcta tggtcgttgg
    14221 tcttgtcttc atctttacat gtatttctat cttctcacgt cttttgggag atatttggat
    14281 gactattatt gacccacgta ttaaattgac tgagaaagga ggcaaataat gtctacaatc
    14341 gataaagaaa aatttcagtt tgtaaaacgt gacgattttg cctctgaaac tattgatgcg
    14401 ccagcatatt cttactggaa atcagtgttt aaacaattta tgaagaaaaa atcaactgta
    14461 gtcatgttgg gaatcttggt agccatcatt ttgataagtt tcatctaccc aatgttttct
    14521 aagtttgatt tcaatgatgt cagcaaggta aacgacttta gtgttcgtta tatcaagcca
    14581 aatgcggagc attggttcgg tactgacagt aacggtaaat cgctctttga cggtgtctgg
    14641 ttcggagctc gtaactccat cctcatttct gtgattgcga cagtgattaa cttggttatc
    14701 ggtgtttttg tcggtggtat ttggggtatt tcaaaatcag ttgaccgtgt catgatggaa
    14761 gtttacaacg tcatctcaaa catcccacct cttttgattg ttattgtctt gacttactca
    14821 atcggagctg gattctggaa tctgattttt gccatgagcg taacaacatg gattggtatt
    14881 gccttcatga tccgtgtgca aatcttgcgc tatcgtgact tggaatacaa cttggcgtca
    14941 cgtactttgg gaacaccaac cttgaagatt gttgccaaaa atatcatgcc tcaattggta
    15001 tctgttattg tgacaaccat gactcaaatg cttccaagct ttatctcata cgaagccttc
    15061 ttgtctttct tcggtcttgg attaccgatt acagtgccaa gtttgggtcg tttgatttcg
    15121 gattattcac aaaacgtaac aaccaatgct tacttgttct ggattccatt gacaaccctt
    15181 gtcttggtat ccttgtccct tttcgtagtt ggtcaaaact tagcggatgc tagtgatcca
    15241 cgtacacata gataggagta gaaatgacaa aagaaaaaaa tgtaattttg actgctcgcg
    15301 atattgtcgt ggaatttgac gttcgtgaca aagtattgac agccattcgc ggcgtttccc
    15361 ttgaactagt cgaaggagaa gtattagcct tggtaggtga gtcaggatca ggtaaatctg
    15421 ttttgacaaa gaccttcaca ggtatgctcg aagaaaatgg tcgtattgcc caaggtagta
    15481 ttgactaccg tggtcaggac ttgacagctt tatcttctca caaggattgg gaacaaattc
    15541 gtggtgctaa gattgcgact atcttccagg acccaatgac tagtttggac cccattaaaa
    15601 caattggtag tcagattaca gaagttattg taaaacacca aggaaaaaca gctaaagaag
    15661 cgaaagaatt ggccattgac tacatgaata aggttggcat tccagacgca gatagacgtt
    15721 ttaatgaata cccattccaa tattctggag gaatgcgtca acgtatcgtt attgcgattg
    15781 cccttgcctg ccgacctgat gtcttgatct gtgatgagcc aacaactgcc ttggatgtaa
    15841 ctattcaagc tcagattatt gatttgctaa aatctttaca aaacgagtat catttcacaa
    15901 caatctttat tacccacgac cttggtgtgg tggcaagtat tgcggataag gtagcggtta
    15961 tgtatgcagg agaaatcgtt gagtatggaa cggttgagga agtcttctat gacccttgcc
    16021 atccatatac atggagtctc ttgtctagct tgcctcagct tgctgatgat aaaggggatc
    16081 tttactcaat cccaggaaca cctccgtcac tttatactga cctgaaaggg gatgcttttg
    16141 ccttgcgttc tgactacgca atgcagattg acttcgaaca aaaagctcct caattctcag
    16201 tatcagagac acattgggct aaaacttggc ttcttcatga ggatgctcca aaagtagaaa
    16261 aaccagctgt gattgcaaat ctccatgata agatccgtga aaaaatggga tttgcccatc
    16321 tggctgacta ggaggaagga aatgtctgaa aaattagtag aaatcaaaga tttagaaatt
    16381 tccttcggtg aaggaagtaa gaagtttgtc gcggttaaaa atgctaactt ctttatcaac
    16441 aagggagaaa ctttctcgct tgtaggtgag tccggtagtg ggaaaacaac tattggtcgt
    16501 gctatcatcg gtctaaatga tacaagtaat ggagatatca tttttgatgg tcaaaagatt
    16561 aatggtaaga aatcgcgtga acaagctgcg gaattgattc gtcgaatcca gatgattttc
    16621 caagaccctg ccgcaagttt gaatgaacgt gcgactgttg attatattat ttctgaaggt
    16681 ctttacaatc accgtttatt taaggatgaa gaagaacgta aagagaaagt tcaaaatatt
    16741 atccgtgaag taggtcttct tgctgagcac ttgactcgtt accctcatga attctcaggc
    16801 ggtcaacgtc aacgtatcgg tattgcccgt gccttggtca tgcaaccaga ctttgttatt
    16861 gcagatgagc caatttcagc cttggacgtt tctgtacgtg cccaagtctt gaacttgctc
    16921 aaaaaattcc aaaaagagct cggcctgacc tatctcttca tcgcccatga cttgtcggtt
    16981 gttcgcttta tttcagatcg tatcgcagtt atttacaagg gtgttattgt agaggttgca
    17041 gaaacagaag aattgtttaa caatccaatt cacccatata ctcaagcctt gctttcagcg
    17101 gtaccaatcc cagatccaat cttggaacgt aagaaggtct tgaaggttta cgatccaagt
    17161 caacacgact atgagactga taagccatct atggtagaaa tccgtccagg tcactatgtt
    17221 tgggcgaacc aagccgaatt ggcacgttat caaaaaggac taaactagta atggttttat
    17281 aatttccatg tcaattttta tggaaattag gctctttgtc aactgtagtg ggttgaagtc
    17341 agctaagctc gagaaaggac aaatttcggc tctttgtcaa ctgtagtggg ttgaagaaaa
    17401 gctaagcttg agaaaggaca aatttcatcc tttctttttt gatgttcaga gcgataaaaa
    17461 tccgtttttt gaagttttca aagtttcgaa aaccaaaggc attgcg
//
LOCUS       DAVHSO010000048        16363 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.048, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000048 DAVHSO010000000
VERSION     DAVHSO010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16363)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16363)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16363
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.048"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(151..861)
                     /gene="treR"
                     /locus_tag="VVR18_001576"
     CDS             complement(151..861)
                     /gene="treR"
                     /locus_tag="VVR18_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose operon repressor"
                     /protein_id="HEU6033073.1"
                     /translation="MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVR
                     KALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDK
                     IIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
                     SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTE
                     SRHKLEKFRFVDFAKRKK"
     gene            1046..3013
                     /gene="treP"
                     /locus_tag="VVR18_001577"
     CDS             1046..3013
                     /gene="treP"
                     /locus_tag="VVR18_001577"
                     /EC_number="2.7.1.201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system trehalose-specific EIIBC component"
                     /protein_id="HEU6033074.1"
                     /translation="MGKFEQEAKDLLQAIGGKENVTAVTHCATRMRFVLGDDKKANVK
                     AIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVV
                     QRVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFL
                     WLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVASTPAADIAA
                     NWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPEVISMIFVPFLSLIPA
                     LILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAI
                     DTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQVSLPATISAYLGVTE
                     PALFGVNVKYIYPFVAGMTGSALAGMLSVTFNVTAASIGIGGLPGILSIQPQYMLPFA
                     GTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAEFVNHEPVELTSVEII
                     SPLTGQVKELSQATDPIFASGVMGQGLVIEPSQGELTSPVNGTVTVLFPTKHAIGIVS
                     DEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDMDVIKAAGLVTETPVI
                     ITNQDAYTATIPGTYPTTIQAGASLMVATRI"
     gene            3191..4816
                     /gene="treC"
                     /locus_tag="VVR18_001578"
     CDS             3191..4816
                     /gene="treC"
                     /locus_tag="VVR18_001578"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HEU6033075.1"
                     /translation="MTLDKGKVVYQIYPKSYKDTTENGIGDFRGIIEKIPYLAKLGVD
                     MVWLNPFYPSPQRDNGYDISDYMAVDPLFGDMADFEEMVCVGKEHKIDFMLDMVLNHC
                     STEHEWFQKALAGDKYYQDFFFIQDQSTDWQSKFGGSAWAPFGDTGKYYLHLFDETQA
                     DLNWRNPNVRKELFKVVNFWRDKGVKGFRFDVINLIGKDEVSVDCPENEGKPAYTDKP
                     IVHNYLRMMNQATFGSDDSFMTVGEMSSTTMENCVLYSSPDRQELSMTFNFHHLKVDY
                     KDGQKWTLAPFDFEELKSLYHSWGKEMSDKDGWSALFWNNHDQPRALNRFVDIQNFRK
                     EGATMLAASIHLSRGTPYIYMGEEIGMIDPDYDSMADYVDVESLNAYQMLLEEGKSQQ
                     EAFQIIQAKSRDNSRIPMQWDASENAGFSTGTPWLKAGKSYKYINVENEIQGPIFTFY
                     QDLIRLRKEMPIISEGSYKPAFEDSKQVYAFERQFEDQKLLVLNNFYAKEVEIDLPAV
                     YQNGQILISNYEDAEVSEKILLKPYQTLAIYVN"
     gene            5072..5320
                     /locus_tag="VVR18_001579"
     CDS             5072..5320
                     /locus_tag="VVR18_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000364981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YneF family protein"
                     /protein_id="HEU6033076.1"
                     /translation="MDLLLAIVLIVLAFLGGALGGMYLVRKQIEKEFADNPRLNAEAV
                     RTLLSANGQKPSEAKVQQVYHQIIRQQKAALANNKKKK"
     gene            5527..6321
                     /gene="racE"
                     /locus_tag="VVR18_001580"
     CDS             5527..6321
                     /gene="racE"
                     /locus_tag="VVR18_001580"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HEU6033077.1"
                     /translation="MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGP
                     RPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASA
                     AIKSSQGGKIGVIGTPMTVQSDIYRQKIHDLDPDLQVESLACPKFAPLVESGALSTSV
                     TKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLL
                     NYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL"
     gene            6318..7289
                     /locus_tag="VVR18_001581"
     CDS             6318..7289
                     /locus_tag="VVR18_001581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000182414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-triphosphate diphosphatase"
                     /protein_id="HEU6033078.1"
                     /translation="MTNKIYEYKDDQDWYVGSYSIFGGVNSLSDYQTDFPLFEFSKIF
                     GDEEYGFPLSVTVLRYGSTYRLFSFVVDMLNQEMGRNLEVIQRHGALLLVENGQLLYV
                     ELPKEGVNVHDFFETSKVRETLLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEV
                     AETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRE
                     NNAKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGY
                     DPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL"
     gene            7265..7786
                     /locus_tag="VVR18_001582"
     CDS             7265..7786
                     /locus_tag="VVR18_001582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HEU6033079.1"
                     /translation="MAKQTIIVMSDSHGDSLIVEEVRDRYVGKVDAVFHNGDSELRPD
                     SPLWEGIRVVKGNMDFYAGYPERLVTELGSTKIIQTHGHLFDINFNFQKLDYWAQEEE
                     AAICLYGHLHVPSAWMEGKILFLNPGSISQPRGTIRECLYARVEIDDSYFKVDFLTRD
                     HEVYPGLSKEFSR"
     gene            7783..8244
                     /locus_tag="VVR18_001583"
     CDS             7783..8244
                     /locus_tag="VVR18_001583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEU6033080.1"
                     /translation="MIAKEFETFLLGQEETFLTPAKNLAVLIDTHNADHATLLLSQMT
                     YTRVPVVTDEKQFVGTIGLRDIMAYQMEHDLSQEIMADTDIVHMTKTDVAVVSPDFTI
                     TEVLHKLVDESFLPVVDTEGIFQGIITRKSILKAVNALLHDFSKEYEIRCQ"
     gene            8235..8975
                     /gene="xerD"
                     /locus_tag="VVR18_001584"
     CDS             8235..8975
                     /gene="xerD"
                     /locus_tag="VVR18_001584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase XerD"
                     /protein_id="HEU6033081.1"
                     /translation="MPMRDRISAFLEEKQGLSVNSKQSYKYDLEQFLDMVGERISETS
                     LKIYQAQLANLKISAQKRKISACNQFLYFLYQKGEVDSFYRLELAKQAEKKTEKPEIL
                     YLDSFWQESDHPEGRLLALLILEMGLLPSEILAIKVADINLDFQVLRISKASQQRIVT
                     IPTALLSELEPLMGQTYLFERGEKPYSRQWAFRQLESFVKEKGFPSLSAQVLREQFIL
                     RQIENKVDLYEIAKKLGLKTVLTLEKYR"
     gene            8975..9703
                     /locus_tag="VVR18_001585"
     CDS             8975..9703
                     /locus_tag="VVR18_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000351912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HEU6033082.1"
                     /translation="MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVST
                     LQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLL
                     GEHLEAKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHT
                     TILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEVITLFLATLELIKTQELI
                     LVQEESFGDIYLMEKKEESQVPQS"
     gene            9722..10291
                     /locus_tag="VVR18_001586"
     CDS             9722..10291
                     /locus_tag="VVR18_001586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein B"
                     /protein_id="HEU6033083.1"
                     /translation="MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQ
                     KYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQ
                     PITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHL
                     EELPVIDELEIQAQESQLFGERIEEDENQ"
     gene            10278..11000
                     /locus_tag="VVR18_001587"
     CDS             10278..11000
                     /locus_tag="VVR18_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEU6033084.1"
                     /translation="MRINKYIAHAGVASRRKAEELIKQGLVTVNGQVVRELATTIKSG
                     DKVEVEGQPIYNEEKVYYLLNKPRGVISSVTDDKGRKTVVDLLPNVKERIYPVGRLDW
                     DTSGVLILTNDGDFTDEMIHPRNEIDKVYVARVKGVANKDNLRPLTRGLEIDGKKTKP
                     AVYEILKVDPVKNRSVVQLTIHEGRNHQVKKMFEAVGLQVDKLSRTRFGHLDLTGLRP
                     GESRRLNKKEISQLHTMAVTKK"
     gene            11000..11242
                     /gene="yidD"
                     /locus_tag="VVR18_001588"
     CDS             11000..11242
                     /gene="yidD"
                     /locus_tag="VVR18_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HEU6033085.1"
                     /translation="MKRILIAPVRFYQRFISPVFPPSCRFDLTCSNYMIQAIEKHGFK
                     GVLMGLARILRCHPWSKTGKDPVPDHFSLKRNQEGE"
     gene            complement(11467..12432)
                     /locus_tag="VVR18_001589"
     CDS             complement(11467..12432)
                     /locus_tag="VVR18_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6033086.1"
                     /translation="MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTI
                     KSSLDEVKLSKVPEKIVTFDLGAADTIRALGFEKNIVGMPTKTVPTYLKDLVGTVKNV
                     GSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIES
                     LASAFGETGTQKAKEELAKLDKSIQEVATKNESSDKKALAILLNEGKMAAFGAKSRFS
                     FLYQTLKFKPTDTKFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLE
                     NALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK"
     gene            complement(12528..13280)
                     /locus_tag="VVR18_001590"
     CDS             complement(12528..13280)
                     /locus_tag="VVR18_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6033087.1"
                     /translation="MKLENIDKSIQKQDILQGISLEVSPQKLTAFIGPNGAGKSTLLS
                     IMSRLTKKDQGVLSIKGREIESWNSQELAQELTILKQKINYQAKLTVEELVSFGRFPY
                     SRGRLRSEDWEKIRETLNYLELTNLKDRYINSLSGGQLQRVFIAMVLAQDTDFILLDE
                     PLNNLDIKQSVSMMQILRRLVEELGKTIIIVLHDINMASQYADEIVAFKDGQVFSKGR
                     TDQIMQADLLSQLYEIPITLADINDKKICIYS"
     gene            complement(13277..14233)
                     /locus_tag="VVR18_001591"
     CDS             complement(13277..14233)
                     /locus_tag="VVR18_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HEU6033088.1"
                     /translation="MQTKSKHTKLFWILIILAIGACLLYFWPITHLSAFAWKLRSQKI
                     IVYLLVAIATGISTISFQTLTENRFLTPSILGIESFYVLLQTLLLVFESKFLQLGKSP
                     ILEFLVLLLVQSLFFLALQGYLKTLMKQDLVFVLLICLALRSLFRNISTFLQVLMDPN
                     EYDKLQNSLFASFQHLNTSILAIGSLIILALTIFFFRKAVVLDVLHLQRETAQILGLD
                     VEKEQKELLWGIVLLTSTATALVGPMAFFGFILANLTYLIVKDYQHKLLFIVAILVGF
                     ISLTLGQALIERVFALEIRISMIIESVGGFLFFILLYRRSRQ"
     gene            complement(14223..15182)
                     /locus_tag="VVR18_001592"
     CDS             complement(14223..15182)
                     /locus_tag="VVR18_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033089.1"
                     /translation="MKLSHYLIGLLLLLVFLSISIGTSDFSWGKLFDFDQQTWLLFQE
                     SRLPRTISILLTASSMSMAGLLMQTITQNQFAAPSTVGTTEAAKLGMVLSLFVFPSAS
                     LTHKMLFAFVSSIVFTLFFLAFMTIFTVKERWMLPLIGIIYSGIIGSVTEVIAYRFNL
                     VQSMTAWTQGSFSMIQTHQYEWLFLGLIILITVWKLSQTFTIMNLGKETSESLGISYS
                     LLEKLALFLVALTTSVTMITVGGLPFLGVIVPNLVRKRYGDNLSQTKLMVALVGANLV
                     LACDILSRVLIRPYELSVSLLLGIIGSLVFILLLWRGGRKDAD"
     gene            complement(15605..16306)
                     /gene="galE"
                     /locus_tag="VVR18_001593"
     CDS             complement(15605..16306)
                     /gene="galE"
                     /locus_tag="VVR18_001593"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEU6033090.1"
                     /translation="MTKTILVTGGTSYIGSHTVKALLNAGYQVHVLDNLSTGNRATVD
                     SRASFKELDVYDASALKAYLEENQIDAVLHCAGEIVVSESIENPSKYFTANVAGMNQV
                     LKVLSEVGIQKIMFSSTASLYGNNCIDKPVTEDTLLDPVNPYAETKLMGERMIYWMAN
                     RYDWKYVIFRYFNAAGAEMDASNGLRVKNPTHIIPNINKTALGQNDSLKIFGDDYDTR
                     DGSCIRDYIYVLDLA"
BASE COUNT         4601 a         3266 c         3769 g         4727 t
ORIGIN      
        1 tctttctaat gagttgtttt gtcgcttttc attataggtc atatgggact ttttttctac
       61 acaaaaatag gctccataat atctataagg gatttaccca ctacaaatat tatagagccg
      121 aaaaaggctg agatctggtg tctcagtctt ttatttcttg cgttttgcaa aatctacaaa
      181 tctaaatttt tctaacttat ggcgactttc ggtaaactga aattggcgtc cgtcttggag
      241 atagactttt gatttaatcg aaacgacata agggtctttg ccaatgtcca tgagaatctt
      301 gtctcggtcg cttgagtggt caatggtgat ttccttctga gcataatcaa taaggagttt
      361 gaggccattt tctatataag aatagataga ctgctcagca atttggcgag tgagatttgg
      421 aattagttcc atatccagat agtccgtatc cagaacggat accagatcat ccaccacacg
      481 ctggcggacc accttccaaa ccatccgaaa ctctgggaaa ccggttatca gtgaggattt
      541 tttatcaata ataatcttgt ccagactgac cacgttggtt ttagagcgca gtccaagttc
      601 tttaactagt tcttggtagc tggttaggtt ggatacaggg aaattgacgg tttcttcttt
      661 gacgacttga gaaccttgcc ctcttatctt tttgatcaat ccttcctctt ggaggagaga
      721 cagggccttt cggacggtat cacgactcac ttgatattgc tccataaggt cgtgctcgct
      781 aggaaggaaa tctccgacag cgtaagtctc gttttgaatg gtttcttgga tttgcttaaa
      841 taattgttgg tatttcttca ttttgcctgc ttaaataggt ttttagtcta gtttaatgaa
      901 cacctgtatc tattttacca tacaagtgct agaaaattta caaaaaaaca ccctttttat
      961 accaaacaag ttgcagacaa gtttggtatc gtttacaata tacttatcaa atcaaacttg
     1021 ctttgacaag tataaggaga atcaaatggg aaaatttgaa caagaagcca aagatctgct
     1081 tcaggcaatt ggaggcaaag aaaatgtgac tgccgtaact cactgtgcga cacggatgcg
     1141 ctttgtttta ggagatgata agaaggctaa tgttaaagct atcgagtcaa ttccagctgt
     1201 taaaggaact tttacaaatg caggtcaatt tcaggtaatc attggaaatg acgtgcccat
     1261 cttttataat gattttacag ccgtttcagg tattgagggt gtttccaaag aagcagccaa
     1321 gtctgcagct aagagtaatc aaaacgtggt ccaacgtgtt atgaccactc tggcggagat
     1381 ttttactccg attattccag ccttgatagt cggaggattg atcctcggtt tccgtaatgt
     1441 cttggaaggt gtccattggt cgatgttgga tggcaagacc atcacagaat cctctcagtt
     1501 ttgggcagga gtcaatcact tcctctggtt gcctggtgaa gctatcttcc agttcttacc
     1561 agtagggatt acttggtctg tttctcgtaa gatgggaacc agccaaattt tgggaattgt
     1621 tctcggaatc tgtttggtat cgcctcagtt gctcaatgcc tatgcggttg cttcaacgcc
     1681 agcagctgat atcgcggcaa actgggtttg gaattttggt tattttactg ttaatcgtat
     1741 tggttaccaa gcccaagtta tcccagcctt gcttgcaggt ttgagtctgt cttatcttga
     1801 aattttctgg cgcaaacata tcccagaagt catttccatg atttttgtac cttttttgtc
     1861 attgattcca gccttgattt tggctcatac tgttttggga ccaatcggtt ggacaattgg
     1921 acaaggactt tcatcagttg tcttggcagg tttaactggt ccagttaaat ggctcttcgg
     1981 tgcaattttt ggtgccctct acgctccatt tgtcatcaca ggtctgcacc atatgaccaa
     2041 tgccattgat acacaattga ttgcggatgc tggtggcact gccctatggc caatgattgc
     2101 tctttctaat attgctcaag gctcagccgt gtttgcctat tatttcatgc atcgccatga
     2161 tgagcgtgag gctcaggttt cacttcctgc aaccatttca gcctatctcg gtgttacaga
     2221 accagctctt tttggggtta acgtaaaata tatttatcca tttgttgctg ggatgactgg
     2281 ttcagccctt gcaggcatgt tatccgttac ttttaatgta actgcggctt ctattggtat
     2341 cggtggtttg ccaggtattc tctctattca acctcaatac atgctgccat ttgcaggaac
     2401 tatgctagtt gcgattgttg ttccaatgct cttgactttc ttcttccgca aggctggtct
     2461 ctttacaaaa acagagggcg atacgaactt gcaggcagaa ttcgttgctc aagaagaagc
     2521 agaatttgtg aaccatgaac cagtagaact tacttcggta gaaattatca gcccactaac
     2581 tggccaagtg aaagaattga gtcaagcgac ggatcctatt tttgcatcag gtgtcatggg
     2641 gcaaggtcta gtcattgaac caagccaagg tgagttgacc tctccagtta atgggacagt
     2701 gacggttctt ttccctacca agcatgccat cggcattgtc tctgacgagg gagttgaatt
     2761 gctcatccac atcggtatgg atacagtagg tcttgatggc aaaggttttg aaagtcttgt
     2821 agtccaagga gatcacgtta cagttggtca gcaactgatt cgttttgata tggatgtcat
     2881 taaggctgca ggtctggtga cagaaactcc tgttatcatc accaaccaag atgcttatac
     2941 agcgactatt cccggaactt atccgacaac gatccaagct ggagcatctc tcatggtcgc
     3001 tacacgaatc taatactctt cgaaaatctc ttcaaaccac gtcagctcta tctgcaacct
     3061 caaaatagtg ttttgagcaa cctgtggcta gcttcctagt ttgttctttg attttcattg
     3121 agtataattg aaatagcaca aatagggacg gaagactgct tcctcccttt tatcagaaaa
     3181 ggagaaacag atgacacttg ataaaggaaa agtagtctat caaatctatc caaaatctta
     3241 caaagacacc actgaaaacg gtattgggga tttccgtggg attatcgaaa aaattcccta
     3301 tttagccaaa ctaggtgtgg atatggtctg gctcaatcca ttctatccaa gccctcaacg
     3361 ggataatggt tacgatattt cagattatat ggcagtggat cctctttttg gtgatatggc
     3421 tgattttgag gaaatggtgt gtgtcggtaa agagcacaag attgacttta tgctggacat
     3481 ggtacttaat cattgttcga cagagcatga atggtttcag aaagccctag ctggtgataa
     3541 gtattatcaa gactttttct tcatccaaga ccaatcaaca gattggcagt ctaagtttgg
     3601 tggttctgca tgggcgcctt tcggggatac tgggaaatac tatcttcacc tatttgatga
     3661 gacccaggct gaccttaact ggcgcaatcc caatgtccgt aaggagcttt tcaaggttgt
     3721 taatttctgg cgcgacaagg gtgtcaaagg ttttcgattt gatgtgatca atttgatcgg
     3781 taaggacgag gtttcagtgg actgtcctga aaatgaaggg aagccagctt atacagacaa
     3841 acccatcgtt cataactatt tgcgtatgat gaaccaagcc acttttggat ctgacgatag
     3901 ctttatgaca gttggggaaa tgtcttctac caccatggaa aactgtgtcc tttattcgtc
     3961 gcctgatcgt caggaattat ccatgacctt taattttcat cacctcaagg tggactataa
     4021 ggatggacaa aagtggacct tggctccctt tgattttgaa gagttgaaga gtctttacca
     4081 tagttggggt aaggaaatga gtgataaaga cggttggagt gccctctttt ggaacaatca
     4141 cgatcaacca cgtgccttga accgttttgt cgatattcaa aacttccgca aggaaggagc
     4201 caccatgcta gcagccagca ttcacctgtc acgtgggaca ccttatatct acatgggtga
     4261 ggaaatcggg atgattgacc cagactatga ttctatggct gattatgtgg atgtcgaatc
     4321 gcttaatgcc tatcagatgc tcttagaaga aggaaagagt cagcaagaag ccttccagat
     4381 tattcaagct aagtcgcgtg ataattcacg cattcccatg cagtgggatg cttcggaaaa
     4441 tgcaggattt tcaacaggca ctccttggtt gaaagctggt aaatcctata aatacatcaa
     4501 tgtagaaaat gaaatccagg gtccgatttt taccttctat caagacttga ttcgactgcg
     4561 taaggaaatg ccaatcattt cagaaggaag ttacaaacca gcctttgaag atagcaaaca
     4621 agtctacgct tttgaacgcc agtttgagga tcaaaagtta ctagtgctca ataactttta
     4681 tgctaaagaa gtggaaatcg acttgccagc agtctaccaa aatggacaga ttttgatatc
     4741 aaactatgaa gatgcagaag tgtctgagaa aattctactc aaaccctatc aaacactggc
     4801 tatttatgta aattaatact cttcgaaaat ctcttcaaac cacgtcagtt ttatctgcaa
     4861 cctcaaagcg gtgctttgag caacctgtgg ctagcttcct agtttgctct ttgattttca
     4921 ttgagtataa acttagcaag gagacctctt tttcagaaaa gcagcgttct ttttgctgtc
     4981 tattccatcc ttgaaagtgt agaacaaact ggtcagggtg gctagtttgt ggtataatga
     5041 aagggactca aaaagaaaca ggagaaaaat gatggattta cttttagcaa ttgtattgat
     5101 tgtgctagct tttctaggag gagctcttgg aggaatgtac ttggttcgta agcaaatcga
     5161 aaaagaattt gctgacaacc cacgtttgaa tgctgaagca gttcgtactc ttttgagtgc
     5221 aaatggtcaa aaaccaagcg aagctaaggt acaacaagtt taccaccaaa tcatccgcca
     5281 acaaaaggca gcccttgcta acaataaaaa gaaaaaataa ataaggaaaa gtctgggatg
     5341 aaagttccag acttctcact atgttggtta tggtttaggg atgagacttt ttccttgcat
     5401 tctattgata tttgattatg attaagagag aggtagttga cattctatca agctgtcggt
     5461 cagttcgttc agtacaagga atcataatga acgatcaatc agaaaaaaga ctagaaagaa
     5521 gactgtatgg ataatcgacc aattggtttt ttggattcgg gtgtcggggg cttgaccgtt
     5581 gtgcgcgagc tcatgcgcca gcttccccat gaagaaatcg tctatattgg agattcggcg
     5641 cgggcgccct atggcccccg tcctgctgag caaattcgtg aatatacttg gcagctggtc
     5701 aactttctct tgactaagga tgtcaaaatg attgtcattg cttgtaacac tgcgactgcg
     5761 gtcgtctggg aagaaatcaa ggctcaacta gatattcctg tcttgggtgt aattttgcca
     5821 ggagcttcgg cagccatcaa gtccagtcaa ggtgggaaaa tcggagtgat tggaacgccc
     5881 atgacggtac aatcagacat ataccgtcag aaaatccatg atctggatcc cgacttacag
     5941 gtggagagct tggcctgtcc caagtttgct cccttggttg agtcaggtgc cctgtcaacc
     6001 agtgttacca agaaggtggt ctatgaaacc ctgcgtccct tggttggaaa ggtggatagc
     6061 ctgattttgg gctgtactca ttatccactc cttcgcccta ttatccaaaa tgtgatgggg
     6121 ccaaaggttc agctcatcga tagtggggca gagtgcgtac gggatatctc agtcttactc
     6181 aattattttg aaatcaatcg tggtcgcgat gctggaccac tccatcaccg tttttacaca
     6241 acagccagta gccaaagttt tgcacaaatt ggtgaagaat ggctggaaaa agagattcat
     6301 gtggagcatg tagaattatg acaaataaaa tttatgaata taaggatgac caggactggt
     6361 atgttgggtc ttatagtatt tttggtggcg ttaacagttt gagcgactat cagacagatt
     6421 ttcctctgtt tgaattctcc aaaatatttg gagatgaaga gtatggtttc ccgctttcag
     6481 ttactgtttt acgctatggt tctacctacc gtttgttctc ctttgtggta gatatgctta
     6541 atcaagaaat gggacgaaac ttggaagtta ttcaacgtca tggggccctg ctcttggttg
     6601 aaaatgggca actcttgtat gtagaattgc ctaaagaagg ggtcaatgtt catgatttct
     6661 ttgagacaag caaggtcaga gaaaccttgt tgattgcgac tcgtaacgaa ggcaaaacca
     6721 aggaattccg agctatcttt gataagttag gctacgatgt ggaaaatctt aatgactacc
     6781 ctgacctgcc tgaagtagca gaaacaggta tgacctttga agaaaatgcc cgccttaagg
     6841 cagaaaccat ttctcaatta acgggcaaga tggttttggc agatgattct ggtctcaaag
     6901 tcgatgtcct tggtggctta ccaggcgtct ggtcagctcg tttcgcaggt gtgggagcaa
     6961 ctgaccgtga aaataatgcc aaactcttgc acgaattggc catggtcttt gaactcaagg
     7021 accgctcggc tcagttccac acaaccctag tcgtagccag cccaaataag gaaagtttag
     7081 ttgttgaagc agactggtca ggttatatta actttgaacc taagggtgaa aatggctttg
     7141 gctatgatcc cctcttcctt gtaggagaaa caggtgagtc atcagctgaa ttaaccctgg
     7201 aagaaaaaaa tagtcaatct caccgtgcct tagccgttaa gaaacttttg gaggtatttc
     7261 catcatggca aagcaaacca tcattgtaat gagcgattcc catggcgata gcttgattgt
     7321 ggaagaagtc cgtgatcgct atgtgggcaa agtcgatgcc gtttttcata acggcgattc
     7381 tgaactacgt ccggattctc cactttggga gggcatccgc gttgttaaag ggaacatgga
     7441 cttctacgcc ggctacccag aacgtctggt gactgagctt ggttcgacca agattatcca
     7501 aactcatggt cacttgtttg acatcaattt caactttcaa aagttggact actgggctca
     7561 ggaggaagag gccgctatct gcctctatgg tcacttgcat gtgccaagtg cttggatgga
     7621 aggcaagatc ctctttctaa atccaggttc tatcagccaa ccacgaggta ccatcagaga
     7681 atgtctctat gctcgtgtgg agattgatga tagttacttc aaagtggact ttttgacacg
     7741 agatcacgag gtgtatccag gtttgtccaa ggagtttagc cgatgattgc caaggagttt
     7801 gagactttct tgttggggca ggaggaaact tttttgaccc ctgctaaaaa tctagctgtg
     7861 ttgattgata cccacaatgc ggatcatgcg accctcttgc ttagtcagat gacctatacc
     7921 cgtgttcccg ttgtgacaga tgaaaaacag tttgttggga cgattggact cagagatatt
     7981 atggcttatc agatggagca tgacttgagc caagaaatca tggcggatac ggatatcgtt
     8041 catatgacaa aaacggacgt agcggttgtt tcgcctgatt tcaccattac ggaggtcttg
     8101 cacaagctag tagatgagtc cttcttaccg gttgtggata cagagggtat tttccaaggg
     8161 attattacgc gcaagtccat cctcaaggcc gttaatgccc tcttgcatga ttttagtaag
     8221 gaatatgaga ttcgatgcca atgagagaca ggatttcagc ctttttagag gaaaagcagg
     8281 gcttgtctgt caattccaag cagtcctata agtatgattt ggagcaattt ttagacatgg
     8341 taggtgagcg gatttctgag accagtctca agatttacca agcccagcta gccaatctaa
     8401 aaatcagcgc ccagaagcga aagatttcgg cctgtaacca atttctctac tttctctatc
     8461 aaaaaggaga ggtggacagc ttttaccgct tggaattagc caaacaagct gaaaagaaga
     8521 cggaaaagcc agagattcta tacctagact ctttttggca ggaaagcgac catccagagg
     8581 gccgcttgct agcgctctta atcctagaaa tggggctctt gcccagtgag attttagcca
     8641 tcaaggttgc ggacatcaat ctggattttc aggtgttgcg aatcagcaag gcttcccaac
     8701 agaggattgt caccattccc acggccttgc tttcagaatt ggaacccttg atggggcaga
     8761 cctatctttt tgaaagagga gagaaaccct attctcgtca gtgggccttt cgtcagttag
     8821 aatcttttgt caaggagaaa ggttttccat ccttatcagc tcaagtctta cgtgaacagt
     8881 ttattctaag acaaatagaa aacaaggtcg atttgtacga aattgcaaaa aaattaggat
     8941 taaaaacagt cctgacctta gaaaaatata gataatggat attaaattaa aagattttga
     9001 aggacccctg gacttgctct tgcatctggt ttctaagtac cagatggata tctacgatgt
     9061 gcccattacg gaagtcatcg aacagtatct agcctatgtc tcaaccctgc aggccatgcg
     9121 tctggaagtg acgggtgagt acatggtcat ggctagtcag ctcatgctga ttaagagtcg
     9181 taaactcctt ccgaaggtag cagaagtgac agacttgggg gatgacctgg agcaggacct
     9241 cctctctcaa atcgaagaat atcgcaagtt caagctcttg ggtgagcact tggaagccaa
     9301 gcaccaagaa cgagcccagt attattccaa agcgccgaca gagttgattt acgaagatgc
     9361 ggagcttgtg catgacaaga cgaccattga cctctttttg gctttttcaa atatcctagc
     9421 caagaaaaaa gaggagtttg cacaaaatca cacgacgatc ttgcgggatg agtataagat
     9481 tgaggacatg atgattatcg tgaaagagtc cttgattgga cgagatcaat tgcgcttgca
     9541 ggatttgttc aaggaagccc agaatgtcca agaggtcatc accctctttt tggcaaccct
     9601 agagttaatc aaaacccagg agctgatcct cgtgcaagag gagagtttcg gagatatcta
     9661 tctcatggaa aagaaggaag aaagtcaagt gcctcaaagc tagacttgat agagaggaaa
     9721 gatgagtact ttagcaaaaa tagaagcgct cttgtttgta gcgggtgaag atgggattcg
     9781 ggtccgccag ttagctgaac tcctctctct gccaccgaca ggcatccagc aaagtttagg
     9841 aaaattagcc cagaagtatg aaaaggaccc agattccagt ttggctttga ttgagacaag
     9901 tggtgcttat agattggtga ccaagcctca atttgcagag attttgaagg aatactctaa
     9961 ggcgcctatc aaccagagct tgtctcgggc tgcccttgag accttgtcca ttattgccta
    10021 caaacagccg attacgcgga tagaaattga tgccatccgt ggagttaact cgagtggagc
    10081 cttggcaaag ttgcaggctt ttgacctgat aaaggaagac gggaaaaagg aagtattggg
    10141 gcgccccaac ctctatgtga ctacggatta tttcctagat tacatgggga taaaccattt
    10201 agaagaatta ccagtgattg atgagcttga gattcaagcc caagaaagcc aattatttgg
    10261 tgaaaggata gaagaagatg agaatcaata agtatattgc tcacgcaggt gtggccagta
    10321 ggagaaaagc agaagagctg atcaagcaag gcttggtgac ggttaacggc caagtggtgc
    10381 gtgaactggc aaccactatc aagtcaggcg acaaggtcga agttgaaggt caacctatct
    10441 acaacgaaga aaaggtctac tatctgctta acaaaccacg tggtgtgatt tccagtgtga
    10501 cagatgataa gggtcgcaag acggttgtcg acctcttgcc caatgtcaaa gaacgtattt
    10561 accctgtggg tcgtttggac tgggatacat caggtgtctt gattttgacc aatgatgggg
    10621 actttacaga cgagatgatt caccctcgta atgagattga caaggtttat gtcgcgcgtg
    10681 ttaaaggtgt ggccaataag gacaatcttc gccccttgac ccgtggtctt gagattgatg
    10741 gtaagaaaac caagccagct gtttatgaaa ttctcaaagt ggacccagtc aaaaatcgct
    10801 ctgtggtgca gttgaccatc catgaagggc gtaaccatca agttaaaaag atgtttgaag
    10861 ctgttggtct ccaagtagat aagttgtctc ggactcgttt cggacaccta gacttgacag
    10921 gactccgtcc aggagaatct cgtcgtctta ataaaaaaga aatcagccaa ctacacacca
    10981 tggctgtaac taagaaataa tgaaacgaat tttaatagcg cctgtgcgct tttaccaacg
    11041 ttttatctca ccagtctttc caccctcttg tcgctttgat ctgacttgtt ccaactacat
    11101 gattcaggct attgaaaaac atggttttaa gggagtattg atgggcttgg ctcggatttt
    11161 acgttgtcat ccctggtcga aaacaggtaa ggaccccgtt ccagaccact tttcccttaa
    11221 acgaaatcaa gaaggggaat gaggtggggt aaatagattt caaaatgata aaaacgcatc
    11281 ctatcaggtt tgagtgaact tgataggatg cgttttagaa tgtcaaaatt ttatactctt
    11341 cgaaaatctc ttcaaaccgc atcagctttc atctgcaacc tcaaaacagt gttttgagca
    11401 acctgcggct agtttcctag tttgctcttt gattttcatt gagtattaaa ttgagtttga
    11461 agtggcttat ttcaaagctt tttgtatgtc ttcaatcatg agttttgttg attcaagtcc
    11521 gcctccgctt agataccaga ggtctggtgt tagttggata atcttaccat ttttagcagc
    11581 aggtgtttca gcgataaggg cattttctag gacaccgtcg ttgctagagt tgtccccacc
    11641 gatggcaagg gtacggttga tgacaaagag gatgtcaggg ttgatttctt tgacactttc
    11701 aaagctgact tcttgtccgt ggcgtgagtc ttcaaatttt gtatcagttg gtttgaattt
    11761 caaggtttgg tacaagaaag agaaacgaga tttggcacca aaggctgcca tttttccttc
    11821 attaaggagg atcgcaaggg cttttttgtc agagctttca tttttagtag cgacttcttg
    11881 gatactcttg tctagcttgg ccaattcttc cttggctttc tgtgtaccag tttcgccgaa
    11941 ggcacttgct aaggattcga tattagcctt ggtagaagtc cagtagtcgt ccttgcttgc
    12001 ttggaagaga acggttgggg cgatttcttt gaatttgtct acgaattttt gtgtacgtgg
    12061 tgaagcgata atcaaatcag gctcaagggc ggcgatagct tctaaatcag gttctttcat
    12121 agaaccaaca tttttgacag ttcccactag gtcttttaga taagtcggaa cagtttttgt
    12181 aggcattccg acgatatttt tttcaaatcc taaagcgcga atagtatccg cagcgccgag
    12241 gtcaaaggtc acaatctttt caggaacttt ggaaagtttg acctcgtcca gtgaactttt
    12301 aatggttacc tctgttggag cagagctact ggtctctgtc tgactagtgc ttgagtttgt
    12361 actacatgca ccaagtagga gcaagaagct ggccactagg gcagtgaaat aaagtttaag
    12421 ggatgttttc ataatttctc ctttttaaaa tgtgataacg atttagggag tctcttaatc
    12481 ttattgacta agagactgaa ggttctctaa cttgagcttt tatgttacta gctatagata
    12541 cagatctttt tgtcattgat atcagctagc gtgatgggaa tctcataaag ttgactgagc
    12601 aggtcagcct gcatgatttg atcggttctt cccttgctaa agacctggcc gtccttgaag
    12661 gcgacaattt catctgcata ctgactggcc atgttgatat cgtggaggac gatgataatg
    12721 gtcttgccga gttcctccac cagtcgtcga agaatctgca tcatgctgac gctttgcttg
    12781 atatcgagat tgttgagtgg ttcgtccagc aagataaagt ccgtatcctg ggccagtacc
    12841 atagcgataa agacgcgctg gagttgcccc cctgacaggc tattgatgta gcggtctttt
    12901 aagttggtca gttctaaata gttcagagtt tctcggattt tttcccagtc ttctgatcta
    12961 agtcgacctc ggctgtaggg aaaacgtcca aaactgacca gttcttcaac agtcaatttg
    13021 gcttggtaat tgattttctg ttttaggatg gttagttctt gggccagttc ttgcgaattc
    13081 cagctctcga tttcacgtcc tttgatactg agaactccct gatctttctt ggttagcctg
    13141 ctcatgatgg agaggagagt cgattttcca gcaccatttg gaccaataaa ggctgtcagt
    13201 ttttgaggac tgacttcaag cgaaatgcct tgcaaaatat cctgtttttg aatggatttg
    13261 tcaatgtttt ccagtttcac tgacgagacc tcctatatag taagataaag aataagaagc
    13321 cacccacact ctcaatgatc atactgatac gaatttccag tgcaaagact cgttcaatca
    13381 aggcttgccc caaggttaag ctaataaatc caaccagaat ggccactata aagagtaact
    13441 tgtgctgata gtctttgaca atcaggtagg tgaggttggc cagtataaag ccgaagaagg
    13501 ccataggtcc taccaaggca gtggccgttg aggtcaaaag cacgattccc cagaggagct
    13561 ctttctgttc tttttcaaca tcgagtccca atatctgagc cgtttctctt tgcaggtgca
    13621 agacatctag aacgactgct tttcgaaaga aaaagattgt caaagcgagg atgatcagag
    13681 aaccgatggc taggatggaa gtgttgagat gttgaaagga ggcaaaaaga ctattttgca
    13741 gtttatcgta ttcgtttgga tccattagga cttgaaggaa ggtgctgata tttcgaaaga
    13801 gacttctgag cgctagacag atcagcagga cgaagaccag gtcttgcttc atcagtgtct
    13861 tcaagtaacc ttgtaaggcg agaaagaaga gggactggac aagaagtaag actaggaatt
    13921 ctaagatagg ggatttgcca agttgaagaa acttgctttc aaaaaccagt agtagggttt
    13981 gtagtaggac gtagaaggat tcaattccca aaatactagg cgtcaggaag cgattttccg
    14041 tcagggtttg aaaactaatg gtcgaaatcc cagtcgcgat ggctaccaag agataaacga
    14101 tgatcttttg ggaacgcaac ttccaagcaa aggctgacaa gtgagtgatg ggccaaaagt
    14161 agagaagaca agctccgatg gcaagaataa tgagaatcca gaagagcttg gtatgtttgc
    14221 ttttagtctg catcttttcg tccccctctc cagagaagta ggataaagac gagactaccg
    14281 atgattccta gcaagagact gacagacaac tcatagggcc taatcagaac tcgggatagg
    14341 atatcgcaag ccagaactag attggcacca accagtgcga ccatgagttt ggtttgactt
    14401 agattatctc catagcgctt gcgaacaaga ttgggaacga taactccgag aaatggtagg
    14461 ccacccacgg taatcatggt gacgcttgtc gttagcgcca ccagaaagag ggccagtttt
    14521 tcaagtaggg agtaggaaat ccccaaactc tcgctggttt ctttccctag attcatgatg
    14581 gtgaaggttt gggataattt ccaaacggtt atcaggatga tgaggcctaa gaagagccac
    14641 tcatactgat gggtctgaat catggagaag gagccctggg tccaggcagt catactctga
    14701 accagattga aacgataggc gataacttct gtgactgagc cgataatccc gctatagatg
    14761 atcccaatca gaggcaacat ccacctttcc tttacagtaa aaatggtcat aaaggctagg
    14821 aagaagaggg tgaatacgat ggatgaaaca aaagcgaaga gcatcttgtg ggtcagacta
    14881 gccgatggaa agacaaaaag gctcagcacc attcccagtt tggcggcttc agtcgttcca
    14941 actgtactcg gtgcagcaaa ctgattttgg gtaatagtct gcatgagaag gcctgccata
    15001 ctcatactag aggcagtcag gagaatactg atagttcttg ggagacggga ctcttgaaag
    15061 aggagccagg tctgctggtc gaaatcaaat agctttcccc atgaaaaatc actggtccca
    15121 atgctaatag agagaaagac taggagtaga agtaagccaa ttaaataatg agaaagtttc
    15181 ataccccgtc ctttcatgta gatttggtat cgaaagatat ctgcggatat aaatgtaaca
    15241 ttatttttct aatctgtcaa taaaatttct gacaatttaa taaatacaac aaggagagag
    15301 caacaagact ttctcctttg ttatcctatt ctaaaatgtt tttaccttaa tctgataaaa
    15361 taatatcttc gagggagtag ctagccgtcc aatcaagata ttgtttagct tttgaagcat
    15421 ctgctaggac actggctggg tcactagcac gtcgagcaac aatctcgtgt gggatttttt
    15481 aatttagtaa ttcttcagca gttttaaaga tttctttgat agtatagcct tttttagttc
    15541 ctaagttaaa gatttgagaa gaactgtctt cttgaaatag gtagttcatt cctttaacat
    15601 gagcctatgc aaggtccaag acataaatgt aatctcgaat acatgaaccg tcacgtgtat
    15661 cgtagtcatc tccaaatatt tttaagctat cattttgtcc caatgcggtc ttgttgatat
    15721 ttggaatgat gtgagttgga tttttcacac gcagaccgtt tgaagcatcc atttcagccc
    15781 cagcagcatt aaagtaacgg aaaataacat atttccagtc gtagcgattg gccatccagt
    15841 aaatcattcg ttcgcccatc agttttgtct ctgcataagg gttgacaggg tcgagcaggg
    15901 tatcttcagt caccggcttg tcaatacagt tatttccata gagagaagca gtcgaagaga
    15961 acatgatttt ttgaatgcca acttcagata agactttgag aacttggttc ataccagcaa
    16021 cgttggcagt gaagtattta cttggatttt caatactttc gctcacaaca atttcacctg
    16081 cacaatggag gacagcatca atctgatttt cttctaagta agcctttaag gcgctagcat
    16141 cataaacatc cagttcttta aagctagcac gactatccac agtcgctcga tttcctgtgg
    16201 agagattatc gaggacatgc acctgatagc cagcatttaa aagagcttta acggtatggg
    16261 agccaatgta gctagtccca cctgtaacaa gaattgtttt ggtcatgatt ttttcctttt
    16321 ctagttttgt actatagtaa attgaaataa gatatgaaca act
//
LOCUS       DAVHSO010000049        16207 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.049, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000049 DAVHSO010000000
VERSION     DAVHSO010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16207)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16207)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16207
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.049"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..816)
                     /locus_tag="VVR18_001594"
     CDS             complement(<1..816)
                     /locus_tag="VVR18_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU6033091.1"
                     /translation="MKRLFILISMVLVSLYMVITSVDHREEILFGNYPSVDVTGMMIN
                     QPVASREEVTEALSHLAVEHNSLIARRIVEPNEAGETRFTYATYGEGKLPEGLTISSK
                     ESAETSDLLGSYLIVSGSLDGVSLQTTLKELGYQGFVSNGEDPFSIVLLLTATPMVLL
                     SLAIFLLTFMSLTLIYRIKSLRQAGIRLIAGESLFGVALRPVLEDVRQLICSVLVSSL
                     LGLGILWYQGALFMATVQLVIIALLLYGLTLAGISTLLSVVYLLGLQENSLVDL"
     gene            complement(893..1189)
                     /locus_tag="VVR18_001595"
     CDS             complement(893..1189)
                     /locus_tag="VVR18_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEU6033092.1"
                     /translation="MKQTVKKLALVASIAATLGGSVAVASAAVQYPEGGVWTYGSGNG
                     GAYSNYYHPSKYHSSTVVSRKTGSSDKGYAGAGGTSRAWIRTSWGEKVAFYYNV"
     gene            complement(1509..2408)
                     /locus_tag="VVR18_001596"
     CDS             complement(1509..2408)
                     /locus_tag="VVR18_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033093.1"
                     /translation="MLIGQKIKEIRIEKGISRPDFCGDEQELTVRQLSRIESGASQPS
                     LPKLDYIARRLGVPVYSLMPDFSALPPAYLELKYQILREPIYGKEEEYDKKEACLEEI
                     YKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILGEHMPQIIEKEVYSTNDMLL
                     IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTKLENFFIIRDTLISGMCCLEKVG
                     VTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAK
                     LIGDGFLVKKLTEEWQEDVKKYL"
     gene            complement(2480..3040)
                     /gene="rnmV"
                     /locus_tag="VVR18_001597"
     CDS             complement(2480..3040)
                     /gene="rnmV"
                     /locus_tag="VVR18_001597"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HEU6033094.1"
                     /translation="MKEKISQVIVVEGRDDTVNLKRYFDVETYETRGSAINDQDIERI
                     QRLHQRHGVIVFTDPDFNGERIRRMIMTVIPTVQHAFLKRDEAVPKSKTKGRSLGIEH
                     ASYEDLKTALAQVTEQFEHESQFDISRSDLIRLGFLAGADSRKRREYLGETLRIGYSN
                     GKQLLKRLELFGVTLAEVEEAMKSYE"
     gene            complement(3040..3813)
                     /locus_tag="VVR18_001598"
     CDS             complement(3040..3813)
                     /locus_tag="VVR18_001598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HEU6033095.1"
                     /translation="MIFDTHTHLNVEEFAGREAEEIALADEMGVTQMNIVGFDKPTIE
                     HALELVDEYEQLYATIGWHPTEAGTYTEEVEAYLLDKLKHSKVVALGEIGLDYHWMTA
                     PKEVQEQVFRRQIQLSKDLDLPFVVHTRDALEDTYEIIKSEGVGPRGGIMHSFSGTLE
                     WAEKFVDLGMTISFSGVVTFKKATDLQEAAKELPLDKMLVETDAPYLAPVPKRGRENK
                     TAYTRYVVDFIADLRGMTTEELAAATTANAERIFGLDSK"
     gene            complement(4119..4784)
                     /locus_tag="VVR18_001599"
     CDS             complement(4119..4784)
                     /locus_tag="VVR18_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
                     /protein_id="HEU6033096.1"
                     /translation="MTILGKDTVQQSAKGESVTQEATPEYKLENTPGGDKGGNTGSSD
                     ANANEGGGSQAGGSAHTGSQNSAQSQASKQLATEKESAKNAIEKAAKNKQDEIKGAPL
                     SDKEKAELLARVEAEKQAALKEIENAKTMEDVKEAETIGVQAIAMVTVPKRPVAPNAA
                     PKTTSAPQATAGTMQDVTYQSPAGKQLPNTGSASSAALASLGLVVATSGFALLGRKTR
                     RRK"
     gene            complement(5047..5181)
                     /gene="rpmH"
                     /locus_tag="VVR18_001600"
     CDS             complement(5047..5181)
                     /gene="rpmH"
                     /locus_tag="VVR18_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HEU6033097.1"
                     /translation="MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
                     "
     gene            complement(5326..6540)
                     /locus_tag="VVR18_001601"
     CDS             complement(5326..6540)
                     /locus_tag="VVR18_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU6033098.1"
                     /translation="MKEYNKSSKLEHVAYDIRGPVLEEAMRMRANGEKILRLNTGNPA
                     EFGFTAPDEVIHDLIMNARDSEGYSDSKGIFSARKAIMQYCQLKKFPNVDIDDIYLGN
                     GVSELIVMSMQGLLDNGDEVLVPMPDYPLWTAAVSLAGGNAVHYICDEAVEWYPDIDD
                     IKSKITSNTKAIVLINPNNPTGALYPKELLLEIIEIARQNDLIIFADEIYDRMVMDGH
                     VHTPVASLAPDVFCVSMNGLSKSHRIAGFRVGWMVLSGPKTHVKGYIEGLNMLSNMRL
                     CSNVLAQQVVQTSLGGHQSVDELLLPGGRIYEQRNFIYNAIQDIPGLSAVKPKAGLYI
                     FPKIDRNMYRIDDDEQFVLDFLKQEKVLLVHGRGFNWQEPDHFRIVYLPRVDELAQIQ
                     EKMTRFLKQYRR"
     gene            complement(6696..6989)
                     /locus_tag="VVR18_001602"
     CDS             complement(6696..6989)
                     /locus_tag="VVR18_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033099.1"
                     /translation="MMKNSFQKSNFLYYGIILVSVLVEVIMICQLESLVPLLYPSFIG
                     FLVFHVLYHLILFLVAKRSGRWDYLMIWGLFLMFNLLYDSFLGLLFLGLSFGM"
     gene            7151..7603
                     /locus_tag="VVR18_001603"
     CDS             7151..7603
                     /locus_tag="VVR18_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HEU6033100.1"
                     /translation="MAQRYQNIMVAIDGSKEADLAFVKGVHSALRNDAKLTIAHVIDT
                     RALQSVSTFDAEVYEELQVDAESLMKEYEKRAKDAGVADVHIVIEMGNPKTLLARTIP
                     DAEEVDLILVGATGLNAFERLLVGSSSEYILRHAKVDLLVVREQEKTL"
     gene            complement(7638..9026)
                     /locus_tag="VVR18_001604"
     CDS             complement(7638..9026)
                     /locus_tag="VVR18_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU6033101.1"
                     /translation="MEVKAVFFDIDGTLVNNRKSVLKSTKDAIKIVKEQGVLVGVATG
                     RGPFFVKELMDDLDLDFAVTYNGQYIFSKDRVLFTSPISKLHLRHLISYAKKEGTEIA
                     LGTKDAMLGSKIMSFGLGSFSQRISRFVPSVLTRTVSQSFNRMVSKVVPQKEEDLLHL
                     MNQPIYQVLMLMTPEESEKAAADFEDLKLTRSNPFASDVINQGNSKLEGIRRVGKEYG
                     FDLNQVMAFGDSDNDLEMLAGVGMSVAMGNGSSSVKEAAKHITTSNQQDGIHKALEHF
                     GVLSSEKVFVSRDYHFNKVKTFHHMMDERTQEEPRAWDLEGATHRAGFKIEELVEFVR
                     AASPSEEDFGQAVSQLHQALDKAADKVAKKTPAQQDLIGQVDALIDTLYFTYGSFVLM
                     GVDPERIFDIVHQANMGKIFPDGKAHFDPVTHKILKPDNWEEKYAPEPAIKKELQRQL
                     KAYERHKERNKS"
     gene            9092..10054
                     /locus_tag="VVR18_001605"
     CDS             9092..10054
                     /locus_tag="VVR18_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HEU6033102.1"
                     /translation="MPKKILVLHTGGTISMQADASGAVVTSSDNPMNHVSNPLEGIQV
                     HALDFFNLPSPHIKPKHMLVLYQKIKEEADNYDGVVITHGTDTLEETAYFLDTMEVPH
                     MPIVLTGAMRSSNELGSDGVYNYLSALRVASDDRAADKGVLVVMNDEIHAAKYVTKTH
                     TTNVSTFQTPTHGPLGLIMKQEILYFKTAEPRVRFDLDHIQGLVPIISAYAGMTDELI
                     DMLDLEHLDGLIIQAFGAGNIPKETAQKLESLLQKGIPVALVSRCFNGIAEPVYAYQG
                     GGVQLQKAGVFFVKELNAQKARLKLLIALNAGLTGQALKDYMEG"
     gene            complement(10083..10421)
                     /locus_tag="VVR18_001606"
     CDS             complement(10083..10421)
                     /locus_tag="VVR18_001606"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033103.1"
                     /translation="MNTIERTRRLVKGCATHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     SKHVFEVVDRTDEVSSKHCFEVADETDEVSSKHVFEVVDETDEVSSKHVFEVVDETDE
                     VSNHTYGKAT"
     gene            complement(10485..11495)
                     /gene="ccpA"
                     /locus_tag="VVR18_001607"
     CDS             complement(10485..11495)
                     /gene="ccpA"
                     /locus_tag="VVR18_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="catabolite control protein A"
                     /protein_id="HEU6033104.1"
                     /translation="MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANS
                     DEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPS
                     VNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGITYSEGL
                     VFESKYSYDDGYALAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSD
                     DSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRK
                     RK"
     gene            complement(11920..12519)
                     /locus_tag="VVR18_001608"
     CDS             complement(11920..12519)
                     /locus_tag="VVR18_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6033105.1"
                     /translation="MKVLVAEDQSMLRDAMCQLLTLQPDVESVLQAKNGQEAIQLLEK
                     ESVDIAILDVEMPVKTGLEVLEWIRSERLETKVVVVTTFKRAGYFERAVKAGVDAYVL
                     KERSIADLMQTLHTVLEGRKEYSPELMEVVMTRPNPLTEQEIAVLKGIARGLSNQEIA
                     DQLYLSNGTIRNYVTNILSKLDAGNRTEAANIAKESGWL"
     gene            complement(12521..13618)
                     /locus_tag="VVR18_001609"
     CDS             complement(12521..13618)
                     /locus_tag="VVR18_001609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU6033106.1"
                     /translation="MLERLKSIHYMFWTSLIFMLFPILPVVIGELPAWHLLVDILFVV
                     TYLGVLITKNQRLSWLFWGLMLVYVAGNTAFVAGNYIWFFFFLSNLLIYHFGVRSLKS
                     LHVWTFLLAQVLVVGRLLIFQRIEVEFLVYMLVILTFVDLMTLGSVRIRLVEDLKEAQ
                     VKQNTQINLLLAENERNRIGQDLHDSLGHTFAMLSVKTDLALQLFQMQAYPQVEKELR
                     EIQQISKESMCEVRTIVENLKSRTLTSELETVKKMLEIAGIEVETDNQLDTASLTQEL
                     DSMASMILLELVTNVIKHAKASKAYLKLERTEKELILTVSDDGCGFAFLKGDELHTVR
                     DRVFPFSGEVSVISQKHPTEVQVRLPYKERN"
     gene            complement(13618..14355)
                     /locus_tag="VVR18_001610"
     CDS             complement(13618..14355)
                     /locus_tag="VVR18_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033107.1"
                     /translation="MKRWIALSKIEFLLTKRQLIYYLLSVGMPTAFYLFFSGIYQDTP
                     GELANFMRDYLISMTAFSMMSTTILSFPAVLHTDKMNNWQKTLRHSPVNMVEYYLSKI
                     TSMLVDYLVSILVVFTVGHFVRGVDMPLVKWVGAAILLIVGSIAFVALGLTLTLLPTS
                     QLMSVVGNLLYLGLAVLGGLWMPISLFPDWMQAVGKCLPTYQLMELLKTFLNEGDINL
                     SATVYLLVFSAVLFGLTIYLQGHKENA"
     gene            complement(14357..15241)
                     /locus_tag="VVR18_001611"
     CDS             complement(14357..15241)
                     /locus_tag="VVR18_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033108.1"
                     /translation="MTVVKVEKLSKKIKDKEILRNISFEINDGECVALIGPNGAGKTT
                     LLDCLLGDKLVTSGQVSIQGLPVTSSKLDYTRAYLPQENVIVQKLKVKELIAFFQRIY
                     PNPLSNQEIDQLLQFVKQQKEQLAEKLSGGQKRLFSFVLTLIGRPKIVFLDEPTASMD
                     TSTRQRFWEIVQELKAQGVTILYSSHYIEEVEHTADRILLLNKGELIRDTTPLAMRSE
                     EIEKHFILPIAYKEVVEQSNLVENWTLKQDSLQVVTREADAFWELLAQAGCRMQEIEV
                     NNRSLLNTIFEETQKGDN"
     gene            complement(15228..15422)
                     /locus_tag="VVR18_001612"
     CDS             complement(15228..15422)
                     /locus_tag="VVR18_001612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033109.1"
                     /translation="MKKGIIYFFIGLSLLVWLVEMFTDWFDQALLRQFIRGALGFGFM
                     IFVVFLMGMEWLKGESHDGG"
     gene            complement(15419..15625)
                     /locus_tag="VVR18_001613"
     CDS             complement(15419..15625)
                     /locus_tag="VVR18_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033110.1"
                     /translation="MGEEEMRNKMIIAVSLVVAGVMTYLMFSGLDEDFYHFPWKVFAG
                     FGIMSWLVREGLKLVRDVKKEFEE"
BASE COUNT         4845 a         3724 c         2836 g         4802 t
ORIGIN      
        1 tagatccacc agactatttt cctgtaaacc aagtagatag acgacactta gtaaggtaga
       61 aatccctgcc aaggtcaatc cataaagtag aagagcaatg atgaccagtt gcaccgttgc
      121 cataaacaag gcaccttgat accagagaat ccccaatccc aaaagactgg ataccagcac
      181 tgagcagata agctgtctca catcttctaa cactggtctg agagcaactc caaacaagct
      241 ctcaccagct attaagcgaa tccctgcctg acgaagggat ttgatccgat aaatcagggt
      301 cagactcata aaggtcagca gaaaaatagc taaactcagt agcaccatag gggtggccgt
      361 caatagtaag actatcgaaa atggatcttc tccattcgaa acaaagcctt gataaccaag
      421 ctctttcaag gtggtctgta agctcactcc atccaaactt cctgacacaa tcaagtaaga
      481 ccctaataaa tcactcgttt ctgcactctc cttggaggaa atggtcagac cttctggaag
      541 ctttccctca ccataagtgg cataggtaaa gcgtgtttct ccagcttcat ttggctcaac
      601 gattcgacga gcaatgagac tattgtgctc taccgccaag tgactcaaag cctctgtcac
      661 ctcttcccga ctagctactg gttgatttat catcattcct gtcacatcaa cagaaggata
      721 gttaccaaat aaaatctctt ctcgatggtc aacggaagtt atcaccatat aaagcgatac
      781 caataccatt gaaatcaaaa taaataaacg tttcatcatt tcctccaaaa agttacttgg
      841 tcacttagtg agaaggtgac caagtaaagc taaacaatag ggctatacca ttctaaacat
      901 tatagtagaa tgcaactttc tctccccaag aagtacgaat ccatgcacga gaagtccctc
      961 cagcaccagc atatcccttg tcagatgaac cagtttttct gctaacaact gttgaactat
     1021 ggtattttga agggtgatag tagtttgagt aagcaccacc gttacctgaa ccataagtcc
     1081 aaacaccacc ttctgggtat tgaacggctg cagaggcaac tgctacactt ccacctaatg
     1141 ttgctgcaat gctcgctaca agagctaatt ttttaactgt ttgtttcata ttgatactcc
     1201 tctatttttg attacaagat tgttgagtta cttgctcctc tttccattat caacgttgat
     1261 actattatat taccaaatga tattctaaaa ttatttgttt ttctctaaat tgtcaaaata
     1321 gcaccctgaa atgaactttt atagtcatta tactccatct ttatcacact atcaaggaca
     1381 tcaatgtcct taaaatctaa ctatttcata ttatttttag cttatatcta aaaaaacagt
     1441 tctaaagacg aactttagaa ctgttttgat acgaggacaa ggacattttt gtcactgatt
     1501 cactatgttt ataaatattt tttgacatcc tcttgccatt cctctgtcaa tttctttact
     1561 agaaatccat ctccaattag cttcgcaaat gttttagaag actgataaaa tgattcagct
     1621 aaactaaaat ctctttctac tcttaatgct tgcttccaca aaaacataaa tacaagaggt
     1681 ttcttttgat aatcttgagt tttatccata atttcttgta aacacgatag ataatcatta
     1741 aaacaatcag ttactcctac cttttcaaga caacacattc ctgaaataag agtatctcta
     1801 attataaaga agttttctaa tttagttacc tttttctgtt ccaaaagaaa gagcattagc
     1861 ttttcgattt gatttataaa tttggcaaga tcttttctaa tgagcatttg ataaaaaaac
     1921 aaacgaatca acaacatatc atttgttgaa taaacttctt tttctatgat ctgaggcata
     1981 tgttccccaa gtattaactc tgcatattca ggccttctag ttctagaagt atccaaacac
     2041 gcctgcaata cttcacatgc taattgttct tctttaggaa gattatcaaa gtatgtttta
     2101 taaatctctt ccaaacacgc ttccttctta tcgtactcct cttctttacc atagattggt
     2161 tcacgtaaaa tctggtattt caattctaaa taagcaggag gaagagctga aaaatccggc
     2221 ataaggctat aaactggaac tcctagccgg cgagcaatat agtctaactt gggcaaactc
     2281 ggttgcgaag ctccactttc aattcgcgac agttgacgaa ctgtcagttc ttgctcatct
     2341 ccacaaaaat ctggacgact aattcctttt tctatccgaa tctctttaat tttttgacca
     2401 attaacatca gacgcctcct cttctacctg cttcgaaaaa tactgtgaaa cttaaaaaat
     2461 tgtaacggct acatctttcc tactcataag atttcatagc ttcttccact tctgccaaag
     2521 taaccccaaa caactctagg cgtttgagga gttgcttgcc gttagaatag ccgattcgga
     2581 gagtctctcc gagatattct ctacgcttac ggctgtctgc ccctgctaga aaaccaaggc
     2641 gaatcaagtc gctacgacta atgtcaaact gactctcatg ttcaaattgt tctgtcacct
     2701 gagctagagc cgttttcagg tcttcatagc tggcatgctc aattcccaga gaacgcccct
     2761 tggtcttgga cttgggaaca gcttcatctc gcttgagaaa ggcatgctga actgttggaa
     2821 tgaccgtcat gatcatgcgc cgaatccgtt ccccattaaa atctgggtct gtaaagacaa
     2881 tgactccatg acgttggtgc aggcgctgaa tccgctctat atcctgatca ttgatggcag
     2941 aacctcgagt ctcataggtc tccacatcga aataacgttt gagattgacc gtatcatcac
     3001 gcccttcaac cacaattact tgggaaattt tctctttcat tacttgctgt ccaatccaaa
     3061 aatgcgttct gcatttgcag tcgttgccgc cgctagctct tctgtcgtca taccacgcaa
     3121 gtcagcgata aagtcgacca catagcgagt ataggctgtt ttattttcac gaccacgctt
     3181 gggtacaggt gctaagtaag gcgcatctgt ttccaccaac atcttgtcca aaggtaactc
     3241 tttagctgct tcttggaggt cagttgcctt cttgaaagtc accactcctg agaaggaaat
     3301 ggtcatacca agatccacaa acttctctgc ccactcaagc gtccctgaaa atgaatgcat
     3361 gataccacca cgaggaccaa cgccctcact cttgataatc tcataggtat cttccagcgc
     3421 atcacgggta tggacaacaa aaggcaaatc caagtcctta gatagctgaa tctgacggcg
     3481 aaaaacctgc tcctgcacct ctttgggcgc tgtcatccaa tggtagtcta agccaatttc
     3541 acctaaagcc acaaccttgg aatgttttaa cttatccaac aagtaagcct caacttcctc
     3601 tgtataagta ccagcttctg taggatgcca accaatagtc gcatagagct gctcatactc
     3661 atctaccaac tccaaggcat gctcaatcgt cggtttatca aaaccaacaa tattcatctg
     3721 tgtcacaccc atctcatcag ccaaggcaat ttcttctgcc tcacgacctg caaattcttc
     3781 tacattcaag tgtgtatgtg tatcaaaaat catctcttct aacctcgttt tctatccttc
     3841 tattatacca aaaaagagga ggggcaccta atttttcggt ttcccctcct ctcttcaata
     3901 gagagctatt ctgctatctt ttctatccga tattgcccat ctcctattcc acagttagag
     3961 acagaagaga ttggctacat tgatagaata ttcctattca gctaaagtat gtgattatct
     4021 tgggttctca cttttctcac ccatcactag gattgatgac ttctcaaaat cccccttata
     4081 atctaacttt aagtagagaa tagaattttc tagctgttct attttctacg tctagtcttt
     4141 cttcctagca aagcaaaacc acttgttgcc accactagac caagactagc aagtgctgca
     4201 cttgatgctg aacctgtgtt aggtaattgt ttgccagcag gtgactggta ggtaacatct
     4261 tgcattgttc ctgcagttgc ttgcggtgca cttgttgtct taggagcagc attaggagcc
     4321 actggtctct taggaactgt aaccatggca atggcttgca ctccaatcgt ttctgcttcc
     4381 ttcacatctt ccatagtttt cgcattttca atctctttga gagctgcttg tttttctgct
     4441 tccactcttg ctaaaagttc tgctttttct ttatcagaaa gcggtgcgcc tttgatttca
     4501 tcctgcttgt tcttggctgc tttttcaatg gcatttttag ctgattcttt ttcagtagct
     4561 aattgcttag aagcttgtga ttgagctgag ttttgtgaac ctgtgtgagc tgatccaccc
     4621 gcctggctac caccgccttc attcgcatta gcatctgagc ttccagtatt gcctccctta
     4681 tctccacctg gtgtattttc tagcttatac tctggtgtag cttcttgagt tacagattca
     4741 cctttcgcag attgttgaac tgtatctttt cctagaatcg tcactactga accatctggg
     4801 aatgtgattg ttgctgtacc atctccagct acttcaactt tatagtaaaa taaaataata
     4861 acaggacaaa tcgatcagga cagtcaaatc gatttctaaa aatgttttag aaacagaggt
     4921 gtactattct agtttcaatc tactgtaaca tcgcttccga atccatttgc atctactgaa
     4981 cttttttaca aaaataaaaa tcagtagact cgagttccta ctgatttttg atagaattcg
     5041 tttggattat gcagccaaaa ctttgcgtcc tttacgacga cgagctgcca atacgcgacg
     5101 accattttta gttgacatac ggttacggaa tccgtgtttg cgcgcacgac gaagtttact
     5161 tggttgataa gtacgtttca cgatgaatac ctcctcatag attttgtatt cgtttagccg
     5221 gctataaagt gatcagttac taaacatact ttactattct atctgattct ttcacttttg
     5281 tcaatagctc taggcaaatg tttccagctt tttcgaatgc aagccctatc tacgatactg
     5341 tttcaagaaa cgagtcatct tttcttggat ttgggctaac tcatcaacac gaggaaggta
     5401 aacgatacgg aagtggtctg gttcctgcca gttaaagcct cgaccatgaa ccaagagaac
     5461 cttttcctgc ttcaagaaat caaggacaaa ctgctcatca tcatcgatac ggtacatatt
     5521 gcggtcgatt tttgggaaga tatagagccc cgccttgggt ttaacggcag acaaacctgg
     5581 aatatcttga atggcattat agatgaaatt tctttgctcg tagattcgtc caccaggaag
     5641 aagcaattca tcgactgatt ggtgaccccc caaggaagtt tgtacgactt gttgggccaa
     5701 aacgttagag caaaggcgca tattggacag catattgagc ccttcgatat agcccttaac
     5761 atgagtctta gggccagaca agaccatcca acccacacgg aaacctgcta tgcggtggga
     5821 ttttgacaga ccattcatgc tgacacagaa gacatctggt gccaagctcg ccacaggcgt
     5881 atgcacatgt ccgtccatta ccatgcggtc atagatttca tccgcaaaga taatcaaatc
     5941 gttttgacgg gcaatctcaa taatctccag caagagttcc ttaggataaa gggctccagt
     6001 tgggttattt ggattgataa ggacgattgc cttggtattg gaagtgattt ttgacttgat
     6061 atcgtcaata tctgggtacc attcaacagc ttcatcacag atatagtgaa cggcatttcc
     6121 tccagctagg ctgacagccg ccgtccatag aggatagtct ggcattggca ctaagacctc
     6181 atccccattg tccaaaagcc cctgcatgga catgacaatc aactcactga caccatttcc
     6241 aaggtaaata tcatcaatat ctacgtttgg gaatttcttc agctggcaat actgcatgat
     6301 ggccttacgg gctgagaaaa ttcctttgga gtcagaatag ccttcactat cacgcgcatt
     6361 cataatcaag tcatgaatga cctcgtctgg cgctgtaaag ccaaattctg ctggatttcc
     6421 tgtattcaga cgtaaaatct tttctccatt cgctcgcatc cgcatggctt cttccaatac
     6481 aggaccacgg atatcataag caacatgctc taacttacta gacttgttat attctttcat
     6541 cttgtttcct caattcatca ggatagtaac attataccac tagaaagaga atgcgacaag
     6601 tttactgaaa tgtgttacta gtttcgtata gaagaaaaac cttgctaaag gcgaggttaa
     6661 gaacgtagag atagcaggta ttttgcaaag acacatcaca taccaaaaga taaacctaga
     6721 aaaagcaagc ctagaaagga gtcataaaga agattaaaca tgaggaaaag cccccatatc
     6781 atcaagtaat cccaacgccc acttcgtttt gcaactagaa ataagattag atggtagagt
     6841 acatgaaaaa ctaaaaatcc aataaaactt ggataaagaa gcggtaccag actctctaat
     6901 tgacagatca tgatcacttc taccaagact gaaactagga taattccata ataaaggaaa
     6961 tttgattttt gaaaagagtt tttcatcatt ctcccttcct tcacttcttt cctgctatcc
     7021 tttcttttat tttatcatat atttatatag agtttaagcc ctaatattct tttgaaaaat
     7081 actttttttg ctttacttct atagtgaaaa ggtttacaat tatagtaaga aaatttcagg
     7141 aggtttcatt atggcacaac gttaccaaaa tatcatggtc gcaatcgatg gttctaagga
     7201 agcggacttg gcttttgtca agggagttca ttctgctcta cgaaacgacg ctaaactcac
     7261 catcgcacat gtcattgaca cacgcgctct ccaaagcgta tccacctttg atgctgaagt
     7321 ttacgaagaa ctccaagtcg acgctgaaag tctgatgaaa gagtacgaaa aacgtgctaa
     7381 agatgctggg gtagcagatg ttcatatcgt cattgaaatg ggaaatccaa agaccctgct
     7441 agcacgtact attccagatg ccgaggaagt ggacctcatc ctcgttggcg caactggtct
     7501 caacgccttt gaacgcctct tggtcggctc ttcatctgaa tacatactcc gccatgctaa
     7561 ggtcgatttg ctggttgtga gagaacaaga aaaaacctta taatcacaaa gaaaaggagc
     7621 ccctagctcc tttttgttta cgatttattt ctctctttat ggcgttcgta agccttgagc
     7681 tggcgctgca gttccttttt aatagcaggt tctggagcat atttttcttc ccaattatct
     7741 ggttttaaga ttttatgggt cactggatca aaatgagcct tgccatctgg aaaaattttc
     7801 cccatattgg cctgatggac aatatcaaaa atacgttctg ggtccacccc catcaagaca
     7861 aaactgccgt aggtgaagta aagcgtgtca atcaaggcat ccacttgccc tatcaaatct
     7921 tgctgagcag gtgtcttctt ggctacttta tctgctgcct tatcaagggc ctgatgaagt
     7981 tgcgatacag cttgaccaaa atcttcttca gaaggactgg ctgctcgaac aaactccacc
     8041 aattcttcta ttttaaaacc agccctatgg gttgcaccct ctaaatccca agctcgaggt
     8101 tcttcttggg ttcgttcatc catcatgtgg tggaaggtct tgaccttatt gaaatgatag
     8161 tcacggctga caaagacttt ttctgaagac aaaacaccaa aatgttccaa ggccttgtgg
     8221 atcccatctt gttgattgct agtggtaatg tgcttggcag cttccttgac actgctacta
     8281 ccatttccca tagcgaccga cataccgacg ccagccagca tttcaaggtc attatctgag
     8341 tcaccaaaag ccatgacttg attgaggtca aagccatatt ctttcccaac tcggcgaatg
     8401 ccttctaatt tagaatttcc ctgattgatg acatccgatg caaaaggatt gctacgtgtc
     8461 aatttcaagt cttcaaaatc agctgccgcc ttctcagatt cttctggtgt catcagcatc
     8521 aaaacttggt agataggctg attcatcagg tgaagcaggt cctcttcctt ttggggaaca
     8581 accttgctga ccatgcgatt aaaagactga ctcaccgtcc gagttaaaac agagggaacg
     8641 aagcgactaa ttcgttggga aaaagaaccc agaccaaagg acatgatttt agaacccaac
     8701 atggcatcct tggtccctag ggcaatctcc gtgccctctt ttttagcata gctaattaga
     8761 tggcgcaaat gtaacttgga aatagggctc gtgaacaaga ctctgtcttt actaaagata
     8821 tactggccat tataggttac cgcaaaatcc agatccaaat cgtccatcaa ttccttaaca
     8881 aaaaaaggtc ctcgccctgt cgctacgcca actagtaccc cttgttcttt gacaatctta
     8941 atcgcatcct tagtagattt caaaacactc ttgcgattgt tgaccaaggt tccatcgata
     9001 tcaaaaaaaa cagctttgac ttccatccta tcccaatctc cccttttgtg atacaatgat
     9061 tataccacat ttcagaaaga gttagtaaat catgcctaag aaaatccttg ttttacatac
     9121 gggtggaact atttccatgc aggccgatgc ttctggcgct gttgtgacga gttcagataa
     9181 tcccatgaac catgtgtcca acccacttga aggaatccaa gtccacgcct tggacttttt
     9241 taaccttcca agtccccata tcaaacccaa acatatgctg gtcctctacc agaaaattaa
     9301 agaggaagca gataactacg atggagtggt gatcacacac ggaaccgata ctttagagga
     9361 aacagcctat ttccttgata ccatggaagt tccccatatg cctatcgttc taacaggagc
     9421 catgcgtagc tccaatgagc tcggtagtga tggtgtttat aattacctaa gtgctttacg
     9481 agtggccagc gatgacaggg ctgctgacaa aggagttttg gtcgttatga acgatgaaat
     9541 ccacgctgcc aagtatgtca ccaaaacaca tacgactaat gtcagcacct tccagactcc
     9601 aacacatggc cccctcggtc tcatcatgaa acaggaaatc ctctacttca aaacagctga
     9661 acctcgtgtt cgctttgacc ttgatcacat acaaggttta gtccctatca tctcggctta
     9721 tgctggtatg acagatgagc tgattgatat gctggattta gaacacttgg acggtttgat
     9781 tatccaagcc ttcggagctg gtaatattcc caaagaaacg gctcaaaaat tagaaagcct
     9841 tctgcaaaaa ggaatcccag tcgctctggt atcacgatgc tttaacggta ttgccgaacc
     9901 tgtttatgcc taccagggtg ggggcgtaca gttgcaaaaa gcaggcgttt tctttgttaa
     9961 agaactcaat gcccaaaaag ctcgcttgaa actcctcatc gccctcaatg ccggactaac
    10021 aggacaggct ttgaaagact atatggaagg ctaatactct tcgaaaatct ctgcaaacca
    10081 cgtcacgtcg ccttaccgta tgtatggtta ctgacttcgt cagtttcatc cacaacctca
    10141 aaaacatgtt ttgagctgac ttcgtcagtt tcatccacaa cctcaaaaac atgttttgag
    10201 ctgacttcgt cagtttcatc tgcaacctca aagcagtgct ttgagctgac ttcgtcagtt
    10261 ctatctacaa cctcaaaaac atgttttgag ctgacttcgt cagttctatc tgcaacctca
    10321 aagcagtgct ttgagctgac ttcgtcagtt ctatctacaa cctcaaaaca gtgtgttgcg
    10381 cagcctttaa ccagccgcct agtccgctct atggtattca ttaagtcaac atctcttgtt
    10441 taagagcaca aaatcaggaa atcttctcga ttccctgatt ttttctattt acgttttcgt
    10501 gttgagctac gttctgtcaa accatgaggt aagagaactt cacgttcttc caactcttcc
    10561 ttatgcataa tcttggtcaa catacgcata ctaatggcac caaggtcata aagaggttgg
    10621 gcaatcgttg tcaagtttgg acgggtaaag cgtgagattt gtgaatcatc actagtaata
    10681 atttcaaaat cttctggcac agaaacaccc ttatcagcca aaccgttcaa gactcctgct
    10741 gccaactcat cacctgtcac aactgctgca gttgcatttg atgaaatcaa acgctctgct
    10801 aaagcgtaac catcatcata gctatattta gattcaaata ccaaaccctc actataagtg
    10861 attcctgctt ttttcaaggt ttccttgtag ccaactaaac gaaccttacc attgatgtca
    10921 tccactagcg gaccgctaac gaaagcaata cgctcatttt ctttagcaag gtaactcact
    10981 gcatcaattg ttgcttgctt atagtcaata ttgacacttg gcaactggtg ctcaacatcg
    11041 acagttcctg cgagaacaat cggagtacgt gaacgcgaaa attctgagcg aattttatct
    11101 gtcaagtgat aacccatata gataatgcca tctacctgct ttgaaaagag ggtattgaca
    11161 acagaaactt ctttctcgtt atcttcatcg ctattagcta ggacaatatt gtacttgtac
    11221 atttctgcaa tatcatcaat ccccttagcc aaactcgaaa aataaccatt ggtaatattt
    11281 ggaatcacga caccgacagt ggttgtcttt ttacttgcaa gaccacgcgc aactgcattt
    11341 ggacgataat ccaaacgatc aattacctct agcacttttt tacgggtatt ctcttttaca
    11401 tttttattgc cattgaccac acggctgacc gtcgccatgg aaacacctgc ttcacgagcg
    11461 acatcataaa tggttactgt atcatctgca ttcattcctt ttcctgtcct ttctatctca
    11521 cacattcttt tacaagtaga ggtactgatt gaagctctat atctacttac aaaagtgaag
    11581 atgtgaaaat ttcgttttca tatttctact tattccattc tatcactaat tgtaaacact
    11641 ttcaagtgtt ttttgaagat tgattgaaaa aatttcatag aaaacctagg tttagctcct
    11701 tgctaccacc ttagactaaa caaaaaggag gaaactaagc cctcctaaag ttatagtaaa
    11761 atgaaataag aacaggataa atcgatcagg acagtcaaat cgatttctaa caatgtttta
    11821 gaagtagagg tgtactattc tagtttcaat ctactatagg tattgttcca ttcactaccg
    11881 tcaattttag cacatagtct tcatgaaaat attatatcat cataaccaac cagattcttt
    11941 tgcgatatta gctgcctctg ttcgattacc agcatccagt tttgaaagaa tattggtgac
    12001 atagtttcga atagttccgt ttgagaggta aagctgatct gcgatttctt ggttggataa
    12061 gccccgggca attcccttta agacagcaat ctcttgttct gtcaacggat tgggacgggt
    12121 catcaccact tccatcaatt caggtgaata ctccttgcgt ccttcgagga cggtgtgcaa
    12181 ggtttgcatg aggtctgcaa tgcttcgttc ctttaataca taagcatcta ctccagcctt
    12241 gaccgcacgt tcaaaatacc cagcacgctt gaaggtcgtc accacaacca cctttgtttc
    12301 aagcctttct gatcgtatcc actccaagac ttcaagacct gtcttaacag gcatttctac
    12361 gtcaaggatg gcgatatcta cagactcctt ttctaatagt tggattgctt cttgcccatt
    12421 cttggcttga aggacagact ccacatctgg ttgaagcgtg agcaattgac acatggcatc
    12481 tcgcaacata ctttgatctt ctgcgactaa tactttcatc ttagtttctc tccttataag
    12541 gtagtcgaac ttgcacttcc gttggatgtt tctgactgat tacacttact tctcctgaaa
    12601 atggaaaaac acgatctcgg actgtatgga gctcatctcc ttttagaaaa gcaaagccgc
    12661 agccatcatc acttactgtt aaaatgagtt ccttctctgt ccgttctaat tttaagtaag
    12721 ctttagacgc tttggcatgt ttgatgacat tggtcaccaa ctcaagcaaa atcatagaag
    12781 ccattgaatc caattcttga gtaaggctag cagtatctag ttggttatct gtttccacct
    12841 caattccagc aatttctaac atctttttca cagtctctag ttcggatgtc aaagttctag
    12901 acttaagatt ttccacaatg gttcgaactt cacacattga ttctttgcta atttgctgta
    12961 tttctcttaa ttccttttcc acttgtggat aagcctgcat ttgaaatagc tgcaaggcta
    13021 gatctgtctt gacactaagc atagcaaagg tatgtcccag actatcatgc aaatcctgac
    13081 cgatacgatt gcgctcattt tctgctagca atagatttat ctgggtattt tgcttgacct
    13141 gagcttcttt caaatcctcg acaaggcgaa ttcgaaccga gcccaaagtc atcaaatcga
    13201 caaaagtaag aattacaagc atatagacta gaaactcaac ttcgattctc tgaaaaatca
    13261 aaagtcgccc cacaacaagg acttgagcaa ggagaaatgt ccatacatgt aaagacttta
    13321 aactacgtac gccaaaatga taaattaaga gattggaaag gaaaaagaaa aaccagatat
    13381 aattcccagc aacaaaggcg gtattcccag ctacatagac cagcatgagc ccccagaaaa
    13441 gccaagatag gcgctggttc ttagttatta aaacacccaa atacgtcact acaaatagaa
    13501 tatcaaccaa taaatgccaa gcaggaagct ccccaatcac tacaggtagg atgggaaaaa
    13561 gcataaaaat caaactggtc caaaacatat agtgtatgct tttcagtctt tcaagcatta
    13621 agcattctcc ttatgacctt gaaggtaaat agtcaaacca aataaaactg ctgaaaaaac
    13681 aagtaaataa actgtggctg atagattgat gtccccctcg tttaagaagg tcttgagcaa
    13741 ctccatcaat tgataggtcg ggagacactt accaactgct tgcatccagt ctggaaataa
    13801 agaaatgggc atccagagtc cgcctaaaac agccaatcct agataaagaa gattgcccac
    13861 aacagacatc agctgactag ttggtaagag agtcaaggtc aagccaagtg ctacaaaagc
    13921 aatactcccc acaatcagca aaatcgcagc tccaacccat tttactagag gcatgtctac
    13981 acctcttaca aaatgtccaa ctgtaaaaac aaccagaatt gagaccaaat aatcaaccag
    14041 catacttgtt atctttgata gataatattc taccatattt acagggctat gacgcaatgt
    14101 tttctgccag ttgttcatct tatcggtatg taaaacagct ggaaatgaga ggatagttgt
    14161 cgacatcatg gaaaaggcag tcatggagat gaggtaatca cgcataaaat tcgcgagttc
    14221 acctggtgtg tcctgataga taccagaaaa aaataaatag aaagccgtcg gcatccctac
    14281 cgacaataga taatagatta attgtcgttt ggtcaataaa aattctatct tactaagtgc
    14341 tatccatcgt ttcatcttag ttatctccct tctgcgtctc ttcaaagatt gtattcaaca
    14401 aactacgatt attaacttcg atttcttgca tcctacatcc tgcttgggct aatagttccc
    14461 agaaagcatc tgcttctcga gtgactactt gtaaagaatc ttgctttagg gtccagtttt
    14521 caaccaaatt tgactgctct acgacttcct tgtaagctat aggaaggata aagtgctttt
    14581 ctatttcctc gctacgcata gctagaggcg tcgtatctcg aatcaactct cccttattta
    14641 agagcaaaat gcggtctgca gtgtgttcca cttcctcaat ataatgggac gaatagagaa
    14701 tggtgactcc ttgcgctttt aactcctgga caatttccca aaaacgttga cgagttgagg
    14761 tatccatgga cgcagtaggc tcatctaaaa aaacaatctt tggtcgccca attaaggtca
    14821 agacgaaaga aaagagacgc ttttgaccgc ctgataattt ttctgccaac tgttcttttt
    14881 gttgcttgac aaactgcaat agttgatcaa tttcctgatt gctcaaagga tttggataga
    14941 tacgttgaaa gaaagcaatc aactctttaa cttttaattt ctgaacgatt acattttctt
    15001 gagggaggta agccctagta tagtctaact tagaactcgt cactggtaaa ccttgaatag
    15061 atacttgacc gcttgtgacc agtttatctc caagcaaaca atctaagagt gttgtctttc
    15121 cggcaccatt tggaccaatt aaggcaacac attcaccatc gttgatttca aaggagatat
    15181 tccgcaaaat ttccttgtct tttattttct tactcaattt ctcaacttta accaccgtca
    15241 tgagactctc ctttcaacca ctccattccc ataaggaaaa cgacgaaaat cataaatcca
    15301 aaccccaaag caccacgaat gaattggcga agcaaggctt gatcaaacca atcagtaaac
    15361 atttccacta accataccaa gagtgacagg ccgataaaga aatagatgat ccctttcttc
    15421 attcctcaaa ctcctttttc acatctctga ctaatttcaa accttctcta acaagccaag
    15481 acatgattcc aaagccagca aagaccttcc aaggaaaatg gtagaaatcc tcatccaatc
    15541 ccgaaaacat gagataggtc ataactcctg ctactactaa acttactgcg ataatcattt
    15601 tatttctcat ctcttcttcc cccatttcat actacaatta tagtctttta aaatcagagg
    15661 agacagaagc ttctgtcact agaaaatatg acaaatgtca taaaaaattc tgttcaaaac
    15721 aagcaagata cactatacaa taaaacacaa tcagaaaaat ctaaggcaac ttcctcaaaa
    15781 gagatatcaa acccaattca caccataatg taaactaata cttatttaaa atcaaaaaga
    15841 gtagaaattt ttatcagaca aacacatata tagtgtattg aatctataac agtaggcctt
    15901 aaatactaaa atatttctat aaattaattt aactttcctg atagaactgt tcatatctta
    15961 tttcaattct ctatattata cgttgaacca aacccttcta ttgctttctt aaaaatttat
    16021 aagagttata aaatctgtta aatttcaatg tgtataccta aactacggta tttattgaaa
    16081 agactgggga caaaaagtat acgctgccaa aatgaattac tgaaaatcaa aaaagagaga
    16141 accaaactga ttccctctta atgtatataa tatctagttt taaaaataca cactcacata
    16201 tctctgt
//
LOCUS       DAVHSO010000050        15971 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.050, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000050 DAVHSO010000000
VERSION     DAVHSO010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15971)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15971)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15971
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.050"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(56..652)
                     /locus_tag="VVR18_001614"
                     /pseudo
     CDS             complement(56..652)
                     /locus_tag="VVR18_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466308.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
     gene            complement(869..1012)
                     /locus_tag="VVR18_001615"
     CDS             complement(869..1012)
                     /locus_tag="VVR18_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001833196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEU6033111.1"
                     /translation="MAESPNSPLSAISDQVGFSDYKYFAKVFKKYLHISPKKLKSLGR
                     IVK"
     gene            complement(1393..1620)
                     /locus_tag="VVR18_001616"
     CDS             complement(1393..1620)
                     /locus_tag="VVR18_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HEU6033112.1"
                     /translation="MFKLIIVEDEHLIRKWLEIAVDYSALGIQVVGTASHGQEGMKLI
                     QEKEPHICLNRHHNANYGCFYDVQSHSYSFL"
     gene            complement(1624..2007)
                     /locus_tag="VVR18_001617"
     CDS             complement(1624..2007)
                     /locus_tag="VVR18_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6033113.1"
                     /translation="MIHKIRFEQFSYDIVCPETVDNQPIPKLFLLPLVENAIKHGMQY
                     RIDLHIDIHITLEADSLTFLVKDNAEGLTKQERFAILDSLESPHTQHGIVNSYKRLSN
                     FFSDVQLDLGVNRQGETWVKFVTKD"
     gene            complement(2340..3116)
                     /locus_tag="VVR18_001618"
     CDS             complement(2340..3116)
                     /locus_tag="VVR18_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000406168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HEU6033114.1"
                     /translation="MEISKGIIFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCSNPESQ
                     RMKPEKMKDAQREKFTLVGEEKTVEEIITEVLKDKEFYEESGGGLTLSGGEIFAQFEF
                     AKAILKSAKEHHIHTAIETTAFVDHEKFIDLIQYVDFIYTDLKHYNSIKHKKVTGVFN
                     QMIIKNIHYAFSQNKTIVLRIPVIPNFNNSLEDAEKFATLFNSLNIDQVQLLPFHQFG
                     ENKYRLLNRKYEMDGVNALHPEDLIDYQKVFLNHHINCYF"
     gene            3238..3984
                     /locus_tag="VVR18_001619"
     CDS             3238..3984
                     /locus_tag="VVR18_001619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000824973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU6033115.1"
                     /translation="MKRLEQIIKLVSEYEKIDVNTLSEKLNVSKVTIRKDLDKLESKG
                     LLHREHGYAVLNSGDDLNVRLSINYEIKRKIVQEAVKLVSDNETIMIESGSTCALLAE
                     EICKQKRNVTIVTNSFFIANFVRAYDSCRIIVLGGEFQKDSQVTVGPLLKEMIQTFHV
                     RQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAASDKVIVLTDSSKFDKRGTVRRFALS
                     QVYEVITDEKLSKQNIATLENAGIMVKVVS"
     gene            3997..4977
                     /locus_tag="VVR18_001620"
     CDS             3997..4977
                     /locus_tag="VVR18_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HEU6033116.1"
                     /translation="MNQDRNKLLSKIAYLYYIENLNQSQIAAKLGIYRTSISRMLTEA
                     RNVGIVKIEIENFDTNMFKLENYVKEKYGLESLEIIPNEFDDNPTILSERISQVAAGV
                     LRNLIDDNMKIGFSWGKSLSNLVDLIHSKSVRNVHFYPLAGGPSHIHAKYHVNTLIYE
                     MSRKFHGECIFMNATIVQENKLLADGILQSRYFENLKNSWKDLDIAVVGIGDFSNKGK
                     HQWLDMLTEDDFKELTKVKTVGEICCRFFDSKGKEVYENLQERTIAISLEDLKNIPQS
                     LAVAYGDTKVSSILSVLRANLVNHLITDKNTILKVLEEDGDLTFREILGE"
     gene            5172..5492
                     /locus_tag="VVR18_001621"
     CDS             5172..5492
                     /locus_tag="VVR18_001621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU6033117.1"
                     /translation="MEIIVPDQIIMGLILYAGDAKQHIYKALDYIKNGTCERCEEEIQ
                     LADAALLEAHNLQTKFLAQEASGTKTEITALFVHSQDHLMTSMTEINLIKEIISLRKE
                     LHKK"
     gene            5538..5846
                     /locus_tag="VVR18_001622"
     CDS             5538..5846
                     /locus_tag="VVR18_001622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU6033118.1"
                     /translation="MVKIGLFCAAGFSTGMLVNNMKIAAQASGVEAEIEAFSQSKLAD
                     YAPNIDVALLGPQVAYTLDKSKEICDKCDVPIAVIPMMDYGMLDGKKVLDLALSLISG
                     "
     gene            5863..7161
                     /locus_tag="VVR18_001623"
     CDS             5863..7161
                     /locus_tag="VVR18_001623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEU6033119.1"
                     /translation="MSKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLI
                     MGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAIMGLISCFSIAYSYAKNSGVEALP
                     AGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIK
                     RKIVIKMPEQVPQAIAKQFEAMIPAFVIFLSSMIVYILAKSLTNGGTFIEMIYSAIQV
                     PLQGLTGSLYGAIGIAFFISFLWWFGVHGQSVVNGVVTALLLSNLDANKAMLASGNLS
                     LENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVAAFPAIFNVNE
                     PVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFL
                     VGGWQGVVTQLLVLVISTVVYFPFFKIQDRLAYQNEIKQS"
     gene            7312..9750
                     /locus_tag="VVR18_001624"
     CDS             7312..9750
                     /locus_tag="VVR18_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HEU6033120.1"
                     /translation="MVNTEVARTTIKTEYFGSLTERMNKYREDVLNKKPYIDAERAVL
                     ATRAYERYKEQPNVLKRAYMLKEILENMFIYIEEESMIAGNQASSNKDAPIFPEYTLE
                     FVLNELDLFEKRDGDVFYITEETKEQLRSIAPFWENNNLRARAGALLPEEVSVYMETG
                     FFGMEGKMNSGDAHLAVNYQKLLQFGLRGFEERARKAKVALDLTDPASIDKYHFYDSI
                     FIVIDAIKVYAKRFVALAKSLAENANPKRKKELLEIADICSRVPYEPATTFAEAIQSV
                     WFIQCILQIESNGHSLSYGRFDQYMYPYMKADLESGKETEDSIVERLTNLWIKTITIN
                     KVRSQSHTFSSAGSPLYQNVTIGGQTRDKKDAVNPLSYLVLKSVAQTHLPQPNLTVRY
                     HAGLDARFMNECIEVMKLGFGMPAFNNDEIIIPSFIAKGVLEDDAYDYSAIGCVETAV
                     PGKWGYRCTGMSYMNFPKVLLITMNDGIDPASGKRFAPSFGHFKDMKNFSELENAWDK
                     TLRYLTRMSVIVENSIDLSLEREVPDILCSALTDDCIGRGKHLKEGGAVYDYISGLQV
                     GIANLSDSLAAIKKLVFEEERISPSQLWHALETDYAGEEGKVIQEMLIHDAPKYGNDD
                     DYADKLVTAAYDIYVDEIAKYPNTRYGRGPIGGIRYSGTSSISANVGQGRGTLATPDG
                     RNAGTPLAEGCSPSHNMDQHGPTSVLKSVSKLPTDEIVGGVLLNQKVNPQTLAKEEDK
                     LKLIALLRTFFNRLHGYHIQYNVVSRETLIDAQKHPEKHRDLIVRVAGYSAFFNVLSK
                     ATQDDIIGRTEHTL"
     gene            9769..10437
                     /locus_tag="VVR18_001625"
     CDS             9769..10437
                     /locus_tag="VVR18_001625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HEU6033121.1"
                     /translation="MEFMLDTLNLDEIKKWSEILPLAGVTSNPTIAKREGSINFFERI
                     KDVRELIGSTPSIHVQVISQDFEGILKDAHEIRRQAGDDIFIKVPVTPAGLRAIKVLK
                     KEGYHITATAIYTVIQGLLAIEVGADYLAPYYNRMENLNIDSNSVIRQLALAIDRQNS
                     PSKILAASFKNVAQVNNALAAGAHAVTAGADVFESAFAMPSIQKAVDDFSDDWFVTQN
                     SRSI"
     gene            10455..11543
                     /locus_tag="VVR18_001626"
     CDS             10455..11543
                     /locus_tag="VVR18_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol dehydrogenase"
                     /protein_id="HEU6033122.1"
                     /translation="MRIFASPSRYIQGENALFENAKSILDLGNYPILLCDQLVYDIVG
                     KRFEDYLHRYGFHIVLALFNGEASDNEINRVVALAEKENCDSIIGLGGGKTIDSAKAI
                     ADLIEKPVIIAPTIASTDAPVSALSVIYTDEGAFDHYLFYSKNPDLVLVDTKVISQAP
                     KRLLASGIADGLATWVEARAVMQANGKTMLGQQQTLAGVAIAKKCEETLFADGLQAMA
                     ACEAKVVTPALENIVEANTLLSGLGFESGGLAAAHAIHNGFTALTGDIHHLTHGEKVA
                     YGTLVQLLLENRPKEELDKYIEFYKKIGMPTTLKEMHLDQVGYDDLIKVGKQATMEGE
                     TIHQMPFKISPSDVAQAIIAVDAYVNSK"
     gene            11998..14499
                     /locus_tag="VVR18_001627"
     CDS             11998..14499
                     /locus_tag="VVR18_001627"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HEU6033123.1"
                     /translation="MSFYNHKEIEPKWQGYWAEHHTFKTGTDASKPKFYALDMFPYPS
                     GAGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTA
                     ENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
                     ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWSESIKD
                     MQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHELVDAITSTEQ
                     AEAVADYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGT
                     GAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLDGLNKEDA
                     IAKIVACLEEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLV
                     LPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPH
                     NTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFN
                     QGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDV
                     VEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLIRSKEIVAENNGALD
                     KVYNETVKAVTEQIDSLKFNTAIAQLMVFVNAANKEDKLYVDYAKGFIQLIAPFAPHL
                     AEELWQTVAATGESISYVTWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREEL
                     QEIALADEKVKAEIDGKEIVKVISVPNKLVNIVVK"
     gene            14693..15388
                     /locus_tag="VVR18_001628"
     CDS             14693..15388
                     /locus_tag="VVR18_001628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001144916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033124.1"
                     /translation="MPVNEYGQMIGESMEGYTPGELPSIDFLEGRYARIEALSVEKHA
                     EDLLAVYGPDTPQEMWTYLFQEPVADMGELVSLLHQMLARKDRFYYAIIDKATGKALG
                     SFSLMRIDQNNRVIEVGAVTFSPELRGTRIGTEAQYLLARYVFEELNYRRYEWKCDAL
                     NLPSRRAAERLSFIYEGTFRQAVVYKGRTRDTDWLSMIDKDWPQVKDRLETWLRPENF
                     DKNGQQYKSLREL"
     gene            15400..15816
                     /locus_tag="VVR18_001629"
     CDS             15400..15816
                     /locus_tag="VVR18_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033125.1"
                     /translation="MITIKKQEIVKLEDVLHLYQAVGWTNYTHQPEMLEQALSHSLVI
                     YLALDGDAVVGLIRLVGDGFSSVLVQDLIVLPIYQRQGIGSALMKEALEDYKDAYQVQ
                     LVTEETERTLGFYRSMGFEILSTYNCIGMTWMNRKK"
BASE COUNT         5082 a         2504 c         3313 g         5072 t
ORIGIN      
        1 gaaatcgatt tgactgtcct gattgatttg tcctgttctt atttcatttt actataccat
       61 caataagtgt gaaaagatct tttacataag accaagcctt atcatctttg taaccacctt
      121 gatcttgtag catatttgtt aattgagcaa aggcgctaga agagtttgct gggtcagcag
      181 ttgcgatttt tccttttagt tcaggtttga gaaggtcgct atatccttcg atgttcatgc
      241 ctttagttaa atcagggtgg acgattaaaa cactaccatc tagtgtataa ggagtagaga
      301 agccagttgt gttttgatat tctttgataa cattatcatt ttcttttgaa atatagtttt
      361 caaagagttc tccgtgggta gcatattgtg tataagaacc accaaagata acatcagcta
      421 caggaacttc tttttctgac tctagttttt tgaaaagttc tccagtacca gcttgaatca
      481 gttctatttt gataccatat ttttcttcaa aggcaggaat agttgctcca attaagcctt
      541 ctgagtttgg tcaataaacg actagcgaac caccgtctcc tttatcagat gaactgtcat
      601 cggcagattc attagaagaa caagcagcat aatacatcca tttctttttc atgatggata
      661 cctccgttgt gttatttaag tttattttaa aacaatgtaa gcgtttttaa aacctacaat
      721 tctattctat agtgtattga atctataaca gtacaccttg actgctaaaa tatttctata
      781 aattaatttg actttcctga tagagatgtt cacatcttat ttcaattcac tatattaggg
      841 taaaattctc tacaaaaaga agaatagcct attttactat tcttccgagt gatttcaatt
      901 tctttgggga aatatggaga tactttttaa atactttggc aaaatattta tagtctgaaa
      961 atccaacttg gtcagagata gcgcttaaag gggagttggg agattcagcc atcttatcta
     1021 tagcttgttt caggcgatat tgtaagatat attcatttag agtcatcttt gataacctta
     1081 tatagatagc tttcgctata gtttaaagct tcagcaatag taatgctcta catagtgctt
     1141 gtggacaaag gagataattt gttgaatgat ttggttttgt gtatcaacct gttggataga
     1201 ggtgagtaaa gtttgatatt cttctaaaaa aggagtttct tgagatgtgc taatttgtaa
     1261 tcgcaaaaca attttttgaa gacattctgt caattccttg gtatcaattg gcttgaataa
     1321 gaaatcaact gctccatatt gcatggcttt ttggcatttt gaaaatcgtt ataacctgat
     1381 aagataactt tttcataaga aagagtacga gtggctttga acatcataaa agcatccata
     1441 attggcattg tgatgtctgt taagacaaat atgaggttct ttttcttgga tgagtttcat
     1501 tccctcttga ccgtgactgg cagttcctac gacttggatg cctaaggcag agtagtctac
     1561 ggcaatctct agccattttc ggatgaggtg ttcatcttct acaataatga gcttaaacat
     1621 gagttagtct ttcgttacaa atttgaccca agtttctcct tggcgattga ctcctaaatc
     1681 tagctggaca tcagaaaaga aattgctcaa tcgtttgtag ctgttcacga tgccatgctg
     1741 ggtatgaggg ctttctaaag agtctaaaat agcgaatcgc tcttgtttgg tgagtccttc
     1801 agcattatcc ttgactaaaa aagttagaga atctgcttcc aaggtaatgt ggatatcaat
     1861 atgaagatca atacggtatt gcatcccatg ttttatagca ttttctacta gaggaagcaa
     1921 gaaaagttta gggataggct gattatcgac agtttctggg cagacaatat cataggaaaa
     1981 ctgctcgaaa cgaatcttat gaatcataag gtaatcctct ataatcttta aatcctgaca
     2041 aatggttgtt tctttttcta aatcggtgat actgtatcgg agaatgcgcg tgaggtcaca
     2101 aaggctgcga tagagcttct atggagaatt tctttttgga gaaatttttt aaaggaatga
     2161 gacatccgct acctccttgg aagggttttt tgtgataagt atagcagttt aaaaattcta
     2221 gagcaaggta aaatagaaaa ggtttggcta aaatttttta gctaaacctt ttgaaaagtt
     2281 aagtatgtat tatagatgct tgttatctgc aaatagctag agcatttcaa ggaaatgaac
     2341 tagaaataac aattaatatg gtggttcaga aatacctttt gataatcaat aagatcttca
     2401 ggatgaagtg cgttgactcc atccatttca tatttccgat ttaataaacg atatttgttt
     2461 tcaccaaatt gatgaaaagg gagtagttga acttggtcga tatttaatga gttaaataga
     2521 gtagcgaatt tttctgcatc ctctaaacta ttgttaaaat taggaataac tgggattctt
     2581 aaaacgatag ttttattttg agaaaaagca taatgaatgt ttttaataat catttgatta
     2641 aaaaccccag tcactttttt atgttttata gaattataat gttttaggtc tgtgtagata
     2701 aaatccacat attgaattaa atcaataaat ttttcatgat caacaaaggc agtagtttca
     2761 atggcagtgt gtatgtgatg ttctttagct gattttaaga tggctttagc aaattcaaac
     2821 tgagcaaata tttcacctcc tgataaagtt aaacctccac cggattcttc gtaaaattct
     2881 ttgtctttta atacctctgt aataatttct tctacagtct tttcttcacc gactaaggtg
     2941 aatttctctc gttgagcatc tttcattttt tcaggtttca ttctttgaga ttcaggatta
     3001 gaacaccatg gacagcgcag aggacatcct tttaaaaaaa cagttgtacg aatacccggg
     3061 ccgtcatgaa ttgaaaagtg ttgaatatta aaaataattc ctttagatat ttccataaga
     3121 gttcctcctc ttcataagtc tatcctatca caaaaacgaa agaaaaacaa ttacgaacga
     3181 aagtttaatt tgttgttttt tgctttttat tttggtagaa taaaacggag gtgtaaaatg
     3241 aaaagattgg aacaaattat taaattagta tcagaatatg aaaagatcga cgttaataca
     3301 ttatcggaaa aattaaatgt atcgaaagta acgattagaa aagatttaga taaattagag
     3361 tcaaaaggtt tattacacag agagcatgga tatgctgtat taaatagtgg agatgactta
     3421 aatgtacgtt tgtcaattaa ttatgaaatt aagagaaaaa ttgttcagga agcagtaaaa
     3481 ttggtgtcag ataatgaaac aataatgata gaatctggat cgacctgtgc tttacttgct
     3541 gaggaaattt gcaagcaaaa aagaaatgtt acgattgtaa caaattcgtt ttttatagca
     3601 aattttgtga gagcttatga ttcatgtcgt attattgttc ttggtggaga gtttcagaag
     3661 gattcacagg ttactgtggg acctttatta aaagaaatga tacagacttt tcatgtgcgt
     3721 caagcttttg ttgggacaga tggttacgat aaagagatgg gctttacagg aaaagattta
     3781 atgcgcagtg aggtagttca atatatttca gcagcgtcgg ataaagtcat tgtactaact
     3841 gactcaagta aatttgataa aaggggtaca gtaagaagat ttgctttaag tcaagtctat
     3901 gaagtaataa cagacgaaaa actttctaaa caaaatatag ctacattaga aaatgctggg
     3961 ataatggtta aggtagtttc gtaagaggtt aagtgtatga atcaagatag gaataaactg
     4021 ctttctaaaa ttgcttatct gtattatatt gaaaacttaa atcagtcaca aatagcagca
     4081 aaattaggaa tttatagaac ctctattagt agaatgttaa cagaagcaag gaatgtagga
     4141 attgttaaaa ttgaaataga gaattttgat accaatatgt ttaagttgga aaattatgta
     4201 aaagaaaaat atggtctgga aagtttagaa attattccaa atgaatttga tgataatcca
     4261 acaattttat ctgaaagaat ttctcaagtt gcagcaggtg tccttaggaa tctaattgat
     4321 gataatatga aaattggctt ttcttggggg aaaagtttaa gtaatttagt agatttaatt
     4381 cacagtaaaa gtgtccgaaa tgttcacttc tatcctctag caggtggtcc tagtcacata
     4441 cacgctaaat accatgtgaa tacactgatt tatgaaatgt ctagaaaatt tcatggagag
     4501 tgtatattta tgaatgcaac gattgtgcaa gaaaataaat tgttagcaga tggtattttg
     4561 caatcaagat attttgaaaa tttgaaaaat agttggaaag atttagatat agctgtagtc
     4621 ggaattggtg attttagcaa taaaggaaaa catcaatggt tagacatgct tacagaggat
     4681 gactttaaag aattgaccaa agttaaaact gtaggagaaa tttgttgtcg attttttgat
     4741 tcaaaaggta aagaagtcta tgaaaactta caggaaagaa cgatagcaat ctctttggaa
     4801 gatttaaaaa atattcctca aagtttagct gttgcttacg gtgatacgaa agtatcttcg
     4861 attctttctg tcttgcgtgc taatttagta aatcatttga ttacagacaa aaatacaatt
     4921 ttaaaagttt tggaagaaga tggggatttg acttttagag agattctagg tgagtgaaaa
     4981 tgatagactg attcagttta tcgtttttct ttttagttga ttgcacattt gtgcttatat
     5041 aaacaaaaat agtttatctg ttgtttttgg attgacaact ttattatgta gttgtattct
     5101 atagttacaa aagaaaattt taaaatttca aatgaaaaaa gctttttaca tagtgaaatg
     5161 aggaggaatt tatggaaatt attgttccag atcaaattat catgggttta attttatatg
     5221 ctggcgatgc gaaacaacat atttataaag cgttagatta cataaaaaat ggtacatgtg
     5281 aacgatgtga agaagaaatc cagttagctg atgcagcctt attagaagct cataatctac
     5341 aaacaaaatt cttggcacag gaagcgtctg gtacaaagac agaaattaca gctctctttg
     5401 ttcattcaca agatcatctc atgactagta tgacggagat taatttaatc aaagaaatta
     5461 ttagtttgag aaaagaactt cataaaaaat aatactagag tattatcatt gttattaaca
     5521 tagaggagga aaacataatg gtgaagattg gtttgttttg tgcagcaggt ttttctactg
     5581 gtatgcttgt aaataatatg aaaattgcag cgcaagctag tggagttgag gcagaaatag
     5641 aggcgttttc tcagtctaaa ttagcggatt atgcgccaaa tatagatgtt gcactattgg
     5701 gtccacaagt tgcttataca ttagataaat caaaagaaat ttgtgataag tgtgatgttc
     5761 cgatagctgt tattccgatg atggactatg gtatgttaga tgggaaaaaa gtattagatt
     5821 tggccctatc tttgattagt gggtaagaaa aggagattta ttatgtcaaa gatggatgtt
     5881 cagaaaatca ttgcaccgat gatgaagttt gtgaatatgc gtggcattat agctctaaaa
     5941 gatgggatgt tagcaatttt gccattgaca gtagttggta gtttgttctt gattatggga
     6001 caattgccgt tcgaaggatt aaataagagc attgctagtg tttttggagc taattggaca
     6061 gagccgttta tgcaagtata ttcaggaact tttgctatta tgggtctaat ttcttgtttt
     6121 tcaattgcct attcttatgc taagaatagc ggagtagagg ctttaccagc tggagttcta
     6181 tctgtatctg cattctttat tttgctaaga tcatcttata tccctaaaca aggtgaggcg
     6241 attggggacg ctattagtaa agtttggttt ggaggccagg gaattatcgg tgctatcatt
     6301 ataggtttgg tagtaggaag tatttatacc ttctttataa agagaaaaat tgttattaag
     6361 atgccagaac aagttccaca agctattgcc aaacagtttg aagcaatgat tccagcattt
     6421 gtaattttct tatcttctat gattgtatat attttagcga agtcattgac taatggcgga
     6481 acattcatag aaatgattta ttctgctatt caagttccgt tgcaaggttt aactggatct
     6541 ttgtatggtg ctattggaat tgcattcttt atatcatttt tgtggtggtt tggtgttcat
     6601 gggcaatcgg tagtaaatgg agtagtgaca gctctgcttt tatctaatct tgatgctaat
     6661 aaagctatgt tagcctctgg taatctatca ttagaaaatg gtgcacatat tgttactcaa
     6721 caatttttag attcattttt aattctatca ggttcaggga ttacgtttgg tcttgtagtt
     6781 gccatgcttt ttgcagcaaa atcaaaacaa taccaagcct taggaaaagt tgcagctttt
     6841 ccagcaatat ttaacgtaaa tgagccagtt gtatttggat ttccgattgt catgaatcca
     6901 gttatgtttg tacctttcat tcttgttcct gtacttgcag ctgtgatagt atatggagct
     6961 attgcaacag gtttcatgca gccattctca ggggtaacat tgccttggag tacaccagct
     7021 attctatcag gatttttggt gggtggatgg caaggtgttg tgactcagtt attagtattg
     7081 gtgatatcta cagtggttta ctttccattc tttaagatac aagatcgttt agcttaccaa
     7141 aatgaaatca aacaatctta gaggtatttg tgtgttactg ttaaactcac acatttgtgc
     7201 taaaaattag agagttaaaa tttttctagt taaaagcttg aaaatttcta taaaaatcgg
     7261 tattatattt tcgaaagaaa taaaaatatt ttcgaaagaa aggtgcttac gatggtaaat
     7321 acagaagtag caagaacaac aatcaagaca gaatattttg gcagccttac tgaaaggatg
     7381 aacaaatatc gagaagatgt tttaaataaa aaaccttata ttgatgctga gagagcagtt
     7441 ctagcaacac gcgcctatga acgatacaag gaacaaccta atgtcctaaa acgtgcatat
     7501 atgctgaaag aaattttgga aaatatgttt atctatattg aagaagaatc tatgattgcg
     7561 ggaaatcaag cttcttccaa taaagatgct cctatttttc cggaatatac actagaattt
     7621 gttctcaatg agttggatct ttttgaaaag cgtgatggag atgttttcta tattacagaa
     7681 gaaacaaaag aacaacttag aagtattgct ccgttttggg aaaataataa tttacgtgct
     7741 agagctggtg ccttattacc tgaagaagtg tctgtttata tggaaacagg attcttcggt
     7801 atggaaggta agatgaattc tggagatgct cacttagcag ttaactatca gaaacttttg
     7861 caatttggtt taagaggttt tgaagagcgg gctcgtaaag cgaaggtagc tctagattta
     7921 acagatccag caagtattga taaatatcat ttttacgact ctatatttat cgtaatcgat
     7981 gctattaaag tatatgcaaa gcgctttgtt gctcttgcta aaagtttagc cgaaaatgca
     8041 aatcctaaac gtaagaaaga attacttgag attgcagata tttgctctag agtcccatat
     8101 gaaccggcaa ctacttttgc agaagctatt caatcagttt ggtttattca atgtatttta
     8161 caaattgaat ctaatggcca ctctctttca tatggccgtt ttgatcaata tatgtatcca
     8221 tatatgaagg ctgatttaga aagtggtaaa gaaacagaag atagcattgt tgaacgtctg
     8281 acaaatcttt ggattaagac aattacaatt aataaggttc gcagtcaatc acatacattt
     8341 tcttcagcag gaagtccttt atatcaaaat gttacaattg gtggacagac tcgagataag
     8401 aaggatgctg ttaacccatt atcttatttg gtattaaaat cagttgcaca aacccatcta
     8461 ccgcaaccta atctaactgt acgttaccat gcaggtttag atgctcgttt catgaatgag
     8521 tgtattgaag tgatgaaact tggttttggt atgcctgcat ttaataatga tgagattatt
     8581 attccttctt ttattgcaaa aggagtattg gaagatgatg cttatgatta cagtgccatt
     8641 ggatgtgttg aaacggcagt tccggggaaa tggggctatc gttgcacagg tatgagttat
     8701 atgaacttcc ctaaggttct acttatcacg atgaatgatg gaattgatcc ggcttcgggt
     8761 aaacggtttg caccaagctt tggtcatttt aaggatatga agaacttttc tgaattagaa
     8821 aatgcttggg ataaaacact aagatatttg acacgaatga gtgttattgt tgaaaattct
     8881 attgatttat cattggaacg agaagttcct gatattctat gttcagcatt gactgatgat
     8941 tgtattggtc gtggaaaaca ccttaaagaa ggtggagcag tatatgatta tatatcagga
     9001 ttgcaagttg gaattgcaaa tttgtcggat tcattagctg caattaaaaa attggtgttt
     9061 gaggaagaac gtataagccc aagtcagctt tggcatgcac tggaaacaga ttatgccgga
     9121 gaagaaggta aggtcattca agaaatgttg attcatgatg cacctaagta tggtaatgat
     9181 gatgattatg ctgacaaatt ggttactgct gcttatgaca tttatgttga tgaaattgct
     9241 aaatatccta atacacgtta tggaagaggg cctattggag gaattcgtta ttcaggaaca
     9301 tcttctatat cagccaacgt agggcaggga cgtggaacat tagcaactcc agatggacgc
     9361 aacgcgggta caccgttagc agagggttgt tcaccatcac ataatatgga tcaacacggc
     9421 cctacatctg ttttaaaatc tgtttcaaaa ttaccaacag atgaaatcgt aggtggggtt
     9481 ctcttaaatc agaaagtaaa tcctcaaacg ttagccaaag aagaagataa attaaaacta
     9541 attgctttgt tacgaacatt ctttaatcgt ttacatgggt accatattca atacaatgtt
     9601 gtttccagag agacgttgat tgacgctcag aaacatcctg aaaaacacag agacttaatt
     9661 gttcgtgttg caggatactc tgcattcttc aatgttcttt ctaaggcaac ccaagatgac
     9721 attataggac gtactgagca tactttgtaa aataaagagg ttctttttat ggaatttatg
     9781 cttgacacat taaatttaga tgagattaaa aagtggtctg aaattttgcc gctagctggg
     9841 gtaacttcaa atcccactat tgcaaaaaga gagggttcta ttaatttttt tgaacgaatc
     9901 aaagatgtaa gagaattgat tggctccaca ccctctattc atgttcaggt gatttctcaa
     9961 gattttgaag gcatcttaaa ggatgctcat gaaattcgaa gacaagcagg agatgatata
    10021 tttatcaaag tacctgttac tccagctgga ttacgtgcaa taaaggtgct aaaaaaagag
    10081 ggctaccata tcactgcaac agctatttat acagttattc agggattatt agctatcgaa
    10141 gtaggagcgg attacctagc tccatattat aatagaatgg aaaatctgaa cattgattca
    10201 aattctgtca ttcgtcaatt agctcttgct attgatagac agaactctcc tagtaagatt
    10261 ttagctgcat cctttaaaaa tgtagcacaa gtaaataatg ctttagctgc aggtgcgcat
    10321 gctgttacag caggagcaga tgtttttgaa tcagctttcg ccatgccatc tatccaaaag
    10381 gcggttgatg atttttctga cgattggttt gttactcaaa atagtcgttc catttagata
    10441 gagaggaaat acatatgaga atttttgcta gtccttctag atatattcag ggggaaaatg
    10501 ccttgtttga aaatgccaaa tcaattttgg atttgggaaa ttacccgatt ctattatgcg
    10561 atcagttggt ttatgatatt gttggaaaac gatttgaaga ttatctacat aggtatggtt
    10621 tccatattgt tctggcgcta tttaatggtg aagcttctga caatgaaatc aatcgagttg
    10681 ttgccttggc tgagaaagaa aattgtgata gtattatcgg tcttggtggg ggaaagacga
    10741 ttgatagcgc aaaagctatt gcagatttga ttgaaaagcc tgttattatt gctccaacaa
    10801 ttgcatcgac cgacgcacct gtatctgctt tatctgttat ttatacagat gaaggtgcat
    10861 ttgatcatta tctattttat tctaaaaatc cagatttagt tttggttgat acaaaagtta
    10921 tttcgcaagc ccctaagcgt ttattagcgt ctggtattgc agatggttta gcaacttggg
    10981 ttgaggcgcg tgcggttatg caggcaaatg gaaaaactat gttgggacaa cagcaaacat
    11041 tggctggagt tgcaattgcg aagaaatgtg aagaaacgct gtttgcagat ggtttacagg
    11101 ctatggcagc ttgtgaagct aaagtggtga caccagcatt agaaaatatt gttgaagcta
    11161 atactttatt gagtggccta ggttttgaaa gtggaggatt agctgcggcg catgcaattc
    11221 ataatggttt tactgcattg acaggcgaca ttcatcattt aacacatggt gaaaaagtag
    11281 cttatggaac tttagtacaa ctattattgg aaaatagacc taaagaagaa cttgataagt
    11341 atattgagtt ttacaaaaaa attggtatgc caacaactct aaaagaaatg catttggatc
    11401 aagttggata tgatgattta ataaaagttg gtaaacaagc aactatggag ggtgagacaa
    11461 ttcatcagat gccgtttaag atttcgcctt cagatgttgc tcaagctatt atcgctgtag
    11521 atgcctatgt aaattcaaaa taaacaataa ggactactgt tttccaaatg gtagtctttt
    11581 attgatcctc gtattgaatt ctatagcaga ttgaaataag atgagaacaa atcgattggg
    11641 aaagtaaaat taatttctat aaatgtttta gcaattgttt cgtactattt cagattcagt
    11701 ccactatacg ttcttcataa atcaaaaagc gacataggtt gtcggctatt tattgtgaat
    11761 acattaatta gcattccagt tttatcttcg gtctaaaata agtattttgt gctatacgag
    11821 ataagcttct tgacttactc cttgatttac tgcataacaa tgggataaaa agtgggagat
    11881 agagcaattc atagtcatca aaattaatga gatacagtat acagtttttc ctttaaacac
    11941 atttcaaatt ccctcaaaaa tggtataata gtaacatcac aaaattggag agagaccatg
    12001 agtttttaca atcataaaga aattgagcct aagtggcagg gctactgggc agaacatcat
    12061 acatttaaga caggaacaga tgcatcaaaa cctaagtttt atgcgcttga tatgttccct
    12121 tatccgtctg gagctggtct gcacgtagga cacccagaag gttatactgc aaccgatatc
    12181 ctcagtcgtt acaaacgtgc gcaaggctac aatgtccttc acccaatggg ttgggatgct
    12241 tttggtttgc ctgcagagca atacgctatg gatactggta atgacccagc agaatttaca
    12301 gcggaaaaca ttgccaactt caaacgtcaa atcaatgcgc ttggattttc ttatgactgg
    12361 gatcgtgaag tcaacacaac agatccaaac tactacaagt ggactcaatg gattttcacc
    12421 aagctttacg aaaaaggctt ggcctatgaa gctgaagtgc cagtaaactg ggttgaggaa
    12481 ttgggaactg ccattgccaa tgaagaagtg cttcctgacg gaacttctga acgtggaggc
    12541 tatccagttg tccgcaaacc aatgcgccaa tggatgctca aaatcacggc ttacgcagag
    12601 cgcttgctca atgacttaga tgaactagat tggtcagagt ctatcaagga tatgcaacgc
    12661 aactggattg gtaaatcaac tggtgccaat gtaactttca aagtaaaagg aacagacaag
    12721 gaatttacag tctttactac tcgtccggac acacttttcg gtgcgacttt cactgttttg
    12781 gctcctgaac atgaattagt agatgccatc acaagcacag agcaagcaga agcagtagca
    12841 gactacaaac accaagccag ccttaagtca gacttggctc gtaccgacct tgccaaagaa
    12901 aaaactggtg tatggactgg tgcttatgcc atcaatcctg tcaatggtaa ggaaattcca
    12961 atctggattg cggattacgt tcttgctagc tatggtacag gtgcggttat ggctgtgcct
    13021 gcccacgatc aacgtgactg ggaatttgcc aaacaatttg accttccaat cgtcgaagta
    13081 cttgaaggtg gaaatgttga agaagctgcc tacacagaag atggccttca cgttaattca
    13141 gacttcctag atggactcaa caaagaagac gctattgcca agattgtggc ttgcttggaa
    13201 gaaaaaggct gtggacaaga gaaggtaacc taccgtctcc gcgactggct ctttagccgt
    13261 caacgttact ggggtgagcc aatcccaatc attcattggg aagatggaac ttcaacagct
    13321 gtccctgaaa gtgaattgcc acttgtcttg cctgtaacca aggatatccg tccctcaggt
    13381 actggtgaaa gtccactagc taacttgaca gactggcttg aagtgactcg tgaagatggt
    13441 gtcaaaggtc gtcgtgaaac aaatactatg ccacaatggg caggttcaag ctggtactac
    13501 ctccgctata ttgacccaca caatactgag aaattggctg acgaggatct gctcaaacaa
    13561 tggttgccag tagatatcta cgtgggtggt gcggaacatg ctgtacttca cttgctttac
    13621 gctcgtttct ggcataaatt cctctatgac ctcggtgttg ttccaactaa ggaaccattc
    13681 caaaaactct ttaaccaagg aatgattttg ggaacaagct atcgtgacca ccgtggggct
    13741 cttgtggcga ctgacaaggt tgaaaaacgt gatggttctt tcttccatgt ggaaacaggg
    13801 gaagagttgg agcaagcgcc agccaagatg tctaaatcgc tcaagaacgt tgtcaaccca
    13861 gacgatgtgg tggaacaata cggtgctgat acccttcgtg tctatgaaat gttcatggga
    13921 ccactcgatg cttcgattgc ttggtcagaa gaaggtctgg aaggaagtcg taagttcctt
    13981 gaccgtgttt accgtttgat tagaagtaag gaaattgttg cggaaaacaa tggcgctctt
    14041 gacaaggttt acaacgaaac tgttaaagct gtcacagagc aaattgattc cctcaaattc
    14101 aacacagcca ttgcccaact tatggtcttt gtcaatgcgg ctaacaagga agacaagctc
    14161 tatgttgact atgccaaagg atttatccaa ttgattgccc catttgcacc tcacttggca
    14221 gaagaactct ggcaaactgt tgctgcaaca ggtgagtcaa tctcttacgt gacttggcca
    14281 acatgggacg aaagtaaact ggttgaagac gaaatcgaaa tcgttgtcca aatcaaaggt
    14341 aaagtccgtg ccaaactcat ggtcgctaaa gacctatcac gtgaagaatt gcaagaaatt
    14401 gctctagcgg atgaaaaagt caaagcagaa attgacggta aggaaatcgt gaaagtgatt
    14461 agtgtaccaa ataaattggt taatattgtt gtaaaataac caatttattt gctgatttcc
    14521 aacctcaaac agtttcccaa actgtttgag ccaactaaac tcgttaatat cgttgtgaaa
    14581 taaggtagga atccttcaga gtagaatctg gaggattttt tgaatcttct tatgaaagta
    14641 tggtatacta tgggcaacta taaagtttga aaagtgaaaa aaggagaaag ctatgccagt
    14701 aaatgaatat ggtcaaatga ttggggagtc aatggaaggt tatacaccag gtgaactgcc
    14761 ttctattgat ttcttagaag ggcgttatgc taggatagag gctctttcag tggaaaagca
    14821 tgcggaggat ttgctagctg tttatgggcc tgatacgcct caggagatgt ggacctacct
    14881 ttttcaggag ccagtagcag atatggggga gctggttagc cttttacatc agatgttggc
    14941 tcgtaaggac cgtttttact atgcaatcat agacaaggcg actggtaagg ctttgggatc
    15001 tttttctctc atgcgcattg accagaataa ccgagtaata gaagtcggag cagtcacttt
    15061 ttctccagag ctaaggggta cacggatagg aactgaagct cagtatctcc tagctcgcta
    15121 tgtttttgag gagctaaact atcgtcgcta cgagtggaaa tgcgatgcct taaatctgcc
    15181 atccagacga gctgcggagc gtttgagctt tatttatgaa ggaaccttcc gtcaggcagt
    15241 ggtttataag ggacgtacga gagatacgga ttggttgtct atgattgata aggactggcc
    15301 tcaagtcaaa gatcgtttgg aaacatggtt gcgtcctgaa aattttgata aaaatggaca
    15361 gcagtacaag agcttgagag aactttaaga ggtgttgaca tgattactat taaaaagcaa
    15421 gaaattgtca agctagagga tgttttacat ctctatcagg ctgtcggttg gacaaattat
    15481 acccatcaac cagagatgct ggagcaggcc ttatctcatt cattagtaat ttatctggca
    15541 cttgatggtg atgctgtggt gggcttgatt cgtttggttg gagatggatt ctcatcagta
    15601 ttggttcagg atttaatcgt tttaccaatc tatcagcgtc aaggaattgg tagtgccttg
    15661 atgaaagagg ctttagagga ttacaaagat gcctatcaag tccagctggt gacagaagag
    15721 acagaaagaa ccttgggctt ctatcgttct atgggctttg aaatcttatc cacctataat
    15781 tgtataggga tgacttggat gaatcgtaaa aaataacaaa acttgttttt tcttaagcaa
    15841 aatttaagga tggtctagta ttatatagtc attaaataaa gacctcctaa ctttatttaa
    15901 taaaatccta aacttttctt tttcataata atctccctta actccaccca atcaggtgga
    15961 gttttttagc t
//
LOCUS       DAVHSO010000051        15710 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.051, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000051 DAVHSO010000000
VERSION     DAVHSO010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15710)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15710)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15710
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.051"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..117
                     /locus_tag="VVR18_001630"
     CDS             <1..117
                     /locus_tag="VVR18_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutT"
                     /protein_id="HEU6033126.1"
                     /translation="TRLLFYDMLPLMEMMVAPDKSEFFYPRRTEDDWEKKIF"
     gene            complement(114..629)
                     /locus_tag="VVR18_001631"
     CDS             complement(114..629)
                     /locus_tag="VVR18_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HEU6033127.1"
                     /translation="MTKDRKQALLQLLKEAPKALNGQSLAEHFHVTRQVIVQDIAILR
                     ADGAPILSTNRGYIYKQIDTNPYVHKLFKVKHEVEEIGQELLAIVDNGGHVQNTLIDH
                     PVYGEIETLLKLSCRRDVQHFLEQVEHSDFRPLSELTDGIHYHLVEAETQQDLHYIEE
                     ALDQLGYLVKD"
     gene            complement(641..1168)
                     /locus_tag="VVR18_001632"
     CDS             complement(641..1168)
                     /locus_tag="VVR18_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU6033128.1"
                     /translation="MNTRKKTQFMTMTALLTAIAILIPIVMPFKIVIPPASYTLGSHI
                     AIFIAMFLSPLMAVFVILASSFGFLMAGYPMVIVFRAFSHISFGALGALYLQKFPDTL
                     DKPKSSWVFNFVLAVVHALAEVLACVLFYATSGTNVENMFYVLFVLVGFGTIIHSMVD
                     YTLALAVYKVLRKRR"
     gene            complement(1450..2013)
                     /locus_tag="VVR18_001633"
     CDS             complement(1450..2013)
                     /locus_tag="VVR18_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU6033129.1"
                     /translation="MKKRSNIAPIAIFFATMLVIHFLSSLIFNLFPFPIKPTIVHIPV
                     IIASIIYGPRVGVTLGFLMGLLSLTVNTITILPTSYLFSPFVPNGNIYSAIIAIVPRI
                     LIGLTPYLVYKLMKNKTGLILAGALGSLTNTIFVLGGIFFLFGNVYNGNIQLLLATVI
                     STNSIAELVISAILTLAIVPRLQTLKK"
     gene            complement(1997..2548)
                     /gene="coaC"
                     /locus_tag="VVR18_001634"
     CDS             complement(1997..2548)
                     /gene="coaC"
                     /locus_tag="VVR18_001634"
                     /EC_number="4.1.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenoylcysteine decarboxylase"
                     /protein_id="HEU6033130.1"
                     /translation="MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQ
                     PLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNM
                     VTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
                     RGALADLTIILERIKETIDEKTL"
     gene            complement(2560..3249)
                     /gene="coaB"
                     /locus_tag="VVR18_001635"
     CDS             complement(2560..3249)
                     /gene="coaB"
                     /locus_tag="VVR18_001635"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="HEU6033131.1"
                     /translation="MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVC
                     LITTKRALKPEPHPNLSIREITNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGL
                     EEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
                     VDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAE
                     LLLEKIQAYHS"
     gene            3479..5149
                     /locus_tag="VVR18_001636"
     CDS             3479..5149
                     /locus_tag="VVR18_001636"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HEU6033132.1"
                     /translation="MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDK
                     IRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVM
                     GIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
                     ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRR
                     LANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIA
                     HGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRAL
                     KMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVL
                     KELCASIDVPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEK
                     IVTEIYRGSKVNFEKKAQTQIAQIVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEI
                     TIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF"
     gene            5477..6652
                     /gene="mutY"
                     /locus_tag="VVR18_001637"
     CDS             5477..6652
                     /gene="mutY"
                     /locus_tag="VVR18_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="HEU6033133.1"
                     /translation="MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPY
                     HIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLATAPEESLLKAWEGLGYYSRVRNM
                     QAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
                     LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVK
                     DFSAAYQNGTMDRYPIKSPKKKPVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFP
                     FIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSH
                     RKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD"
     gene            6707..7411
                     /locus_tag="VVR18_001638"
     CDS             6707..7411
                     /locus_tag="VVR18_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000722069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6033134.1"
                     /translation="MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE
                     QPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDSEFDKVIGLELGADDYVTKP
                     FSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
                     HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPE
                     YILTRRGVGYYMRNNA"
     gene            7404..8753
                     /gene="vicK"
                     /locus_tag="VVR18_001639"
     CDS             7404..8753
                     /gene="vicK"
                     /locus_tag="VVR18_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall metabolism sensor histidine kinase
                     VicK"
                     /protein_id="HEU6033135.1"
                     /translation="MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQI
                     NQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFY
                     MTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
                     LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSH
                     ELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATS
                     HLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDN
                     ILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSR
                     AQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED"
     gene            8755..9564
                     /locus_tag="VVR18_001640"
     CDS             8755..9564
                     /locus_tag="VVR18_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEU6033136.1"
                     /translation="MSEIGFKYSILASGSSGNSFYLETSKKKLLVDAGLSGKKITSLL
                     AEINRKPEDLDAILITHEHSDHIHGVGVLARKYGMDLYANEKTWQAMENSKYLGKVDS
                     SQKHIFEMGKTKTFGDIDIESFGVSHDAVAPQFYRFMKDDKSFVLLTDTGYVSDRMAG
                     IVENADGYLIEANHDVEILRSGSYAWRLKQRILSDLGHLSNEDGAEAMIRTLGNRTKK
                     IYLGHLSKENNIKELAHMTMVNQLAQADLGVGVDFKVYDTSPDTATPLTEI"
     gene            9655..9897
                     /locus_tag="VVR18_001641"
     CDS             9655..9897
                     /locus_tag="VVR18_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="HEU6033137.1"
                     /translation="MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYD
                     ARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE"
     gene            9899..10153
                     /locus_tag="VVR18_001642"
     CDS             9899..10153
                     /locus_tag="VVR18_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="HEU6033138.1"
                     /translation="MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKAL
                     VGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHRRDIY"
     gene            10200..10973
                     /locus_tag="VVR18_001643"
     CDS             10200..10973
                     /locus_tag="VVR18_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ion transporter"
                     /protein_id="HEU6033139.1"
                     /translation="MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSII
                     DLVIWGVFVIDYSWRFFTTKRKWRFILENIFDLLAILPLNAIFTVFRLGRIFRLVKLT
                     KLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIVLVGSSILSVVEEKSFS
                     DSLWWALVTVTTVGYGDIVPASIFGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDE
                     QIKLDKLQDELSSQRILLEKQSKKIEELHKMIQDLIEKT"
     gene            complement(11233..12219)
                     /locus_tag="VVR18_001644"
     CDS             complement(11233..12219)
                     /locus_tag="VVR18_001644"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019768616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HEU6033140.1"
                     /translation="MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLH
                     EKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNL
                     AINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
                     ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELF
                     EGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIG
                     QPAVVGAHGIIRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN"
     gene            12413..14881
                     /gene="gyrA"
                     /locus_tag="VVR18_001645"
     CDS             12413..14881
                     /gene="gyrA"
                     /locus_tag="VVR18_001645"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001152996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HEU6033141.1"
                     /translation="MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHR
                     RILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVD
                     GHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
                     FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTG
                     ALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVR
                     LVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAI
                     QNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIR
                     IIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIAD
                     LADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQILSLEDEDLIEESDVLITLS
                     NRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRL
                     KGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTS
                     VKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRI
                     ATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAK
                     ITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQI
                     VTFTTVAVAEKEEVGTENETEGEA"
     gene            14881..15624
                     /gene="srtA"
                     /locus_tag="VVR18_001646"
     CDS             14881..15624
                     /gene="srtA"
                     /locus_tag="VVR18_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtA"
                     /protein_id="HEU6033142.1"
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVW
                     NTNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPE
                     LEMNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNA
                     KNGMKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIV
                     KGDLKETKDYSQTSDEILTAFNQPYKQFY"
BASE COUNT         4826 a         2730 c         3482 g         4672 t
ORIGIN      
        1 acgcgcttac tcttctatga tatgctacca ttgatggaaa tgatggtagc tcccgacaag
       61 tcagagtttt tctatcctcg ccgtacagaa gacgattggg aaaagaaaat cttctagtct
      121 tttactaaat aacctagctg atccaaggcc tcctcgatat agtggaggtc ttgttgtgtt
      181 tcggcttcga ctaggtggta atggatgcca tctgtcaatt cagatagagg tctaaagtca
      241 gaatgctcga cttgttctag aaaatgttgc acatctctgc gacaagacag tttaagcaag
      301 gtttcaattt ctccataaac gggatggtca atcaaggtat tctggacatg cccaccatta
      361 tcgacaatag caaggagttc ctgaccgatt tcttcaactt catgtttcac tttgaaaagt
      421 ttgtgaacat aaggattggt atcaatttgc ttatagatgt agccacgatt ggtggatagg
      481 ataggagcgc catcggctct caaaattgca atgtcctgca caatgacctg acgtgtgaca
      541 tgaaaatgtt ccgccaaact ttggccatta agggctttag gagcttcttt caagagttgg
      601 agcagggctt gtttgcgatc ttttgtcata gcttttcctt ttaacggcgt tttcgaagca
      661 ctttatagac agctagtgct aatgtatagt ctaccatact atggataatt gtgccaaatc
      721 caactagtac aaatagaaca tagaacatgt tttctacatt ggtacccgaa gttgcgtaaa
      781 aaaggacaca ggctaatact tcagcaaggg catgaacaac agccaaaaca aaattgaaaa
      841 cccaggaaga ttttggttta tctagggtat cggggaattt ttgtaggtaa agagctccta
      901 aagcaccaaa agatatatgg gaaaaagccc gaaaaacgat aaccatggga tagccagcca
      961 tcaaaaatcc aaaactagag gctaggatga caaaaactgc catcaagggc gacaagaaca
     1021 tggctataaa aatagcgatg tggctcccca aagtatagga agcaggtgga atgacaatct
     1081 tgaaaggcat aacaattgga atcaaaatcg caatagccgt taaaagggct gtcattgtca
     1141 taaattgtgt ctttttccgt gtattcacaa gaatctcctt tttaactgca tatacactag
     1201 tatggtacaa taaaccagac aataaagcaa gaatttactt gggtttatag atcatttttt
     1261 agttaaaagt tatagtagat tgaaactaga atagtccacc tctacttcta aaacattgtt
     1321 agaaatcgat ttgactgtcc tgatcgattt gtcctgttct tatttcgttt tactatagta
     1381 aagatttcat taaaaagaaa ctgtatagag caaaatctcc accttcaggt ttgaaagcgg
     1441 agattgtttt tattttttca aggtttgtag tcgtggaaca atggctaggg ttagaattgc
     1501 agaaatgacc aattcagcaa ttgaatttgt tgagataacg gttgccagaa gaagttggat
     1561 atttccatta taaacatttc caaataggaa gaagattcct ccaaggacaa agatagtatt
     1621 tgtcaaggaa ccaagggctc cagctaaaat cagaccagtc ttgtttttca tcagtttata
     1681 gactaagtaa ggagttaaac caatcaaaat acgtgggacg atggcaatga tagctgagta
     1741 gatgtttccg tttggtacga agggagagaa gaggtagctt gtcggtagaa tcgtaatcgt
     1801 gttaaccgtc aagctaagta atcccatcaa aaatccaagt gtaaccccaa ctcgtggacc
     1861 ataaataatg ctggcaataa tgacaggaat atgaacaatg gtcggtttga ttggaaatgg
     1921 aaaaaggtta aagataagtg agctcagaaa gtgtatcacg agcatggtag caaaaaagat
     1981 agcaatgggt gcaatattag agcgtttttt catcgatagt ttcctttatt ctttctaaaa
     2041 taattgtgag gtcagctaaa gctcctcgtc cgtggtctcc acaagctagt agggattcct
     2101 taggagcaat cagctgatag ccgtaggttt ctaatgtttt cagattattc tgagttactg
     2161 gatggtcata catttttgta ttcatagcag gagctattag tttgggaata tgacttggta
     2221 gggctagagc tgtactggtt accatgttgt ccgcaaatcc gtgagctagt tttgcaatag
     2281 tgttagcagt tgcaggtacc acgataaata aatctgcttt ttttccaagt tcgatatgat
     2341 tgacctgatc aggatagggt tccttcatga catccaagtg gacaggattc tgtgagagta
     2401 cctgtagtgt caaaggttgg ataaactctg tagcagcctg agtcattaag acagtgactt
     2461 gatggccttg tttttttaga gaactgacta aatctgccga cttataagag gcgattgaac
     2521 ccgttacagc caagagaatg tttgccatag ttttcctttc taagaatgat aggcttgaat
     2581 tttttcaagg aggagttctg caatttcttc tttagtctgg actgtttgaa gctgattttt
     2641 ctcaacaaat atagctcggt gctgatctgc tgaaatttga gtcaggtcat tcgcgatgat
     2701 taaatctgct tgattcttga taagactttt tcgtgcaatg tcaaccagat gatcttcggt
     2761 aacatcaacc agcagtttga aaccaatcag atgaatagtg ggattccatt ccttgactag
     2821 ggatatgatt ttgggtgtct ttttaaggaa caaaacctga acctcatcag ttgaagaaat
     2881 cttggcctga tgattctgct tgcttaaaaa ttcttttaga ttggagctag cctgaacttc
     2941 ctcaagccct gtcatataaa caggagtgta gtcagaaaca gccattgagt ggatcaagac
     3001 ctgataatcc tgaacacgtt cttgcatttc tattagaagg tccttggtat tggtaatttc
     3061 tcgaatactt aggttaggat gaggctctgg cttcagagct cgttttgtcg taattaaaca
     3121 aacttcatgc cctgcagaaa gcaaagtctc tgtgataatt ttccccaagt gacctgtaga
     3181 atggttagtg atagagcgga cgctatcgat agcttcactg gtaccgcccg atgtaactaa
     3241 aattttcata gcactattgt acacaaaaat aagcggtaag taaaatgaaa gtgataaatt
     3301 tttggtaaaa acgaagattt actatagttt caaactataa agccatataa aatttaagaa
     3361 aggactctaa aagtcttaaa aacagagata tttacgaacg tttagagagt tttaagatgt
     3421 taaaaatctt gttttgtgat ataatgaatt atcatataag aggttagagg aattttgaat
     3481 gaaaacagat attgaaatcg cacagagtat tgagttgaag ccaattgttg atgttgtaga
     3541 gaaacttggt atttcttacg acgatttgga gttgtacgga aagtacaagg ctaaactcag
     3601 ctttgataaa attcgggcag ttgagagcaa tccagtcggt aaattgatct tggttactgc
     3661 catcaaccca acacctgcag gtgaaggaaa gtcgacgctt accattggtc ttgcggatgc
     3721 cttgaacaag attggcaaga aaaccatgat tgctatccgc gaaccgtctc ttggtccagt
     3781 catggggatc aagggtggtg ctgctggtgg tgggtatgca caagttctgc caatggaaga
     3841 catcaacctc cactttactg gagatatgca tgctattaca actgccaaca atgccctttc
     3901 tgccttgatt gacaaccact tgcaccaagg gaatgagctg ggaattgatc aacgtcgtat
     3961 cctctggaaa cgcgttgtgg acttgaacga ccgtgcgctc cgccatgtga ctgttggtct
     4021 tggtggtcct ctaaacggta ttccacgtga ggacggtttt gatattacag ttgcttcaga
     4081 aatcatggca attctttgct tggcaacgga catcgaggac ttgaaacgtc gtttggcgaa
     4141 tatcgttatt ggttatcgct atgaccgtac gcctgtttct gtaggtgatt tgcaggttga
     4201 gggtgccttg gctttgattt tgaaggatgc tattaagcca aacttggttc agacaattta
     4261 cggtacacct gcctttgtac acggtggtcc atttgccaat atcgctcatg gctgtaactc
     4321 tgttttggcg acgacaacag cccttcactt ggctgattac actgttactg aagctggttt
     4381 tggtgcggat cttggtgctg agaaattcct tgatatcaag acaccaaact tgccaacatc
     4441 tccagatgca gttgttattg tcgcaaccct tcgtgccctt aagatgaatg gtggtgtggc
     4501 taaagacgct ctgactgaag aaaatgtaga ggcagttcgt gcaggttttg ctaacttgaa
     4561 acgccacgtt gaaaatatcc gtaagttcgg tattccagca gttgtagcta ttaacgaatt
     4621 tgtatctgat acagaagctg aaattgcagt cttaaaagaa ctctgtgcct caatcgatgt
     4681 accagttgaa ttggctagtg tctgggctga tggagcagaa ggtggagtag cacttgccga
     4741 aacagttgtt aagacaattg ctgaaaatcc agctaactat aaacgtttgt acgataatga
     4801 cctttctgtc caagaaaaga ttgaaaaaat tgtcactgaa atctatcgtg gtagcaaagt
     4861 gaactttgag aagaaagctc aaacacaaat tgctcaaatc gttcaaaacg gttgggacaa
     4921 attgccaatt tgtatggcta aaactcaata cagtttctca gacaatccaa atgcgcttgg
     4981 agcaccagaa aactttgaaa ttaccattcg tgaattggta ccaaaattag gtgcaggctt
     5041 catcgttgcc ttaactggtg atgttatgac catgccaggt cttccaaaac gtccagcagc
     5101 tctcaacatg gatgttgaaa gcgatggaac tgtgctaggc ttgttctagt ggattgaaat
     5161 tgactttaag tgagtttgga aataatatcc aagctcattt tttctcagac tgcaagcagt
     5221 tcatcaataa gatttatact cttcgaaaat cttttcaaac tacgtcagct tcaccttgcc
     5281 gtaggtatat gatactgact ctgtcagttc tatccacaac ctcaaaacag tgttttgagc
     5341 aacctgcggc tagcttccta gtttgctctt tgattttcat tgagtataag tagatagaaa
     5401 agttatatac tatctattga aaatattata aatcagatac aaagacaggt gaaaccttct
     5461 gtgttatact agagatatgt tagatttgaa agaatacggt atcgtcatgt ggccggagga
     5521 gaaagtcatt tctttccgtg agaaacttct cgcttggtat gatgaaaaca aaagagattt
     5581 gccttggagg agaagtaaaa atccttatca catctgggta tctgaaatca tgcttcagca
     5641 gaccagggtg gatacagtta tcccttacta cgaaagattt ttggactggt ttccaactgt
     5701 cgaaagtctg gcaactgcgc ctgaggagag tttactgaaa gcttgggagg gcttgggcta
     5761 ttattctcga gttcgcaata tgcaggctgc agcccagcag attatgactg actttggtgg
     5821 ccaatttcca aatacctatg aaggaatttc cagcttgaaa gggattggac cttacacagc
     5881 aggagccatt tccagtattg cttttaactt gcctgagcca gctgtagatg gtaatgtcat
     5941 gcgggtcttg gcgcgtctgt ttgaagtcaa ccacgatatt gggattccaa gtaatcgaaa
     6001 aatttttcag gcaatgatgg agatcttgat taatccagat cgtccaggtg attttaatca
     6061 agccttgatg gacttagggt ctgatattga gtctcctgta aatcccagac ctgaagaaag
     6121 cccagtcaag gactttagtg cggcatatca gaatggaacc atggaccgtt atccaattaa
     6181 atctcctaag aaaaagccgg ttcctattta tcttaaagcc ttagttgtga aaaattctca
     6241 aggacaattt ttacttgaaa aaaatgaaag cgaaaagctc ttggcaggtt tttggcattt
     6301 cccctttata gaagttgata acttttcgca agaagagcag tttgacctct ttcatcaggt
     6361 tgcggaagaa agtgtgaact ttggccccag tccagaagag agtttccagc aggactatga
     6421 cctagatgtt gattggcttg atgtttgttt tgatacagtc cagcatgttt ttagtcatcg
     6481 aaaatggcat gtacagattg tagcaggtca ggtgagtgac ttccatgatt tttcagatag
     6541 ggaagttcgt tggctttcac cagaagaatt caagaattac ccacttgcca aaccccaaca
     6601 aaaaatctgg caggcttatg cacaagccaa cttagacagt agccaagact agctattgtg
     6661 tcttctgact attttttggt ataatagtag agaaaaaggt gaacatatga aaaaaatact
     6721 aattgtagat gatgagaaac caatctcgga tattatcaag tttaatatga ccaaggaagg
     6781 ttacgaagtt gtaactgctt ttaatggtcg tgaagcgcta gagcaatttg aagcagagca
     6841 accagatatt attattctgg atttgatgct tccagaaatt gatggtttag aagttgctaa
     6901 gaccattcgt aagacaagca gtgtgcccat tcttatgctt tcagccaaag atagtgaatt
     6961 tgataaggtt atcggtttgg aacttggggc agatgactat gtaacgaaac ccttctccaa
     7021 tcgtgagttg caggcgcgtg ttaaagctct tctgcgtcgt tctcaaccta tgccagtaga
     7081 tggtcaggaa gcagatagta aacctcaacc tatccaaatt ggggatttag aaattgttcc
     7141 agacgcctac gtagctaaaa aatatggcga agaactagac ttaacccatc gtgaatttga
     7201 gcttttgtat catttagcat cgcatacagg tcaagtcatc acgcgcgaac acttgcttga
     7261 gactgtctgg ggttatgact attttggtga tgtccgcaca gttgatgtga ctgtacgacg
     7321 tctgcgtgag aagattgaag atacgcccag ccgaccagag tatatcttga cgcgccgtgg
     7381 tgtagggtat tacatgagaa ataatgcttg atttactgaa acaaaccatt tttaccagag
     7441 attttatctt tatcctgatt ttgttaggtt tcatccttgt tgtgaccctc ttattactgg
     7501 aaaatagacg tgataatatt cagttgaagc aaatcaatca aaaggttaaa gatttgattg
     7561 caggagatta ttccaaggtt cttgatatgc aaggtgggtc tgaaatcacc aatattacca
     7621 ataatttgaa tgacttgtcg gaggttattc gtctcactca ggaaaatcta gaacaagaga
     7681 gtaagaggct aaatagtatt ctgttttata tgacagatgg ggttcttgcg accaaccgtc
     7741 ggggtcagat tatcatgatt aacgatacag ccaagaagca actggggttg gttaaggaag
     7801 atgttctgaa tagaagcatt ttggaattgc tcaagataga agaaaactat gaattgcgtg
     7861 atttgattac ccaaagtcca gaattgttgc tagattccca agatatcaat ggcgaatatt
     7921 tgaaccttcg agttcgcttt gccttgatac gtcgagagtc tggctttatt tcaggtttgg
     7981 tggctgtttt gcatgatacg acggagcagg agaaggaaga acgcgaacga agactctttg
     8041 tttccaatgt tagccatgag ttacggactc ctctgactag cgtaaaatcc tatcttgaag
     8101 ccttggatga gggggctttg tgtgaaactg tagcaccaga ctttatcaag gtttctcttg
     8161 atgagaccaa ccgtatgatg cgcatggtga cggatctcct ccatctttca cgtattgata
     8221 atgctaccag tcacctagat gtggaactga ttaacttcac tgcttttatt acctttatcc
     8281 tcaatcgttt tgacaagatg aaaggacagg aaaaggagaa aaaatatgag ttggtgagag
     8341 attatcccat caattctatc tggatggaaa ttgatacaga taagatgacg caggttgtcg
     8401 acaatatttt aaataatgct attaagtatt cgccagatgg gggtaaaatc actgtcagaa
     8461 tgaagacaac tgaagaccag atgattttat ccatttctga ccacggtttg gggattccta
     8521 agcaggattt accacgtatc tttgaccgtt tctatcgtgt ggatcgtgct agaagtcgtg
     8581 cacaaggtgg tacaggtcta ggactgtcta tcgctaaaga aattatcaaa caacataagg
     8641 gctttatttg ggccaagagt gaatacggca agggttcaac ctttaccatt gtgctccctt
     8701 atgataagga tgcagtgaaa gaagaagtat gggaggatga agtagaagac tagaatgagt
     8761 gaaataggct ttaaatacag tattttagcg tcgggttcca gtggaaattc tttttatctg
     8821 gaaacctcaa aaaagaagct tttagtagat gcaggcttgt ctggcaagaa aattaccagt
     8881 ctgctagctg aaattaaccg taagccagaa gacctggatg ccatcttgat tacccatgag
     8941 cattcagatc atatccatgg agtaggcgtt ttggctcgca agtatggtat ggatctttat
     9001 gccaatgaaa agacctggca agctatggaa aatagtaaat atcttggcaa ggtggattct
     9061 tcgcaaaagc atatttttga aatgggtaaa accaaaacct ttggagatat cgacatcgag
     9121 agttttggtg taagccatga tgcagtcgca ccgcagttct atcgctttat gaaggatgat
     9181 aagagttttg tcctcttgac agatacaggt tatgtcagtg accgtatggc gggcattgtc
     9241 gaaaatgcgg atggttatct tatcgaggcc aaccatgatg tagagatttt gcgatcaggt
     9301 tcttacgctt ggcgcctcaa acaacgaatc ctatctgacc ttggtcacct ttctaacgag
     9361 gacggtgctg aagctatgat tcggacgcta ggaaatcgta ctaagaagat ttaccttggg
     9421 catttatcta aggaaaacaa tatcaaggaa ctggctcata tgaccatggt caatcagctg
     9481 gctcaagctg atctgggagt cggagtagac tttaaggttt atgatacctc accagatacc
     9541 gcaacaccat tgacagagat atagaaagaa cgctgagaag gtgttctttt tatattgact
     9601 ggacacctaa aaagtaatac aatggtgtta ccattaaaaa agggagcaca aaagatgact
     9661 actattacat taaaagtttc tgaagctgat aaaacattta tgaaagcaat ggctaagttt
     9721 gaaggagttt ccctttcgga acttattcgc accaaaactc ttgaagccct agaagatgaa
     9781 tacgatgctc gtgtggcaga tttagcctat caagagtatt tagaagactt ggaaaaagga
     9841 gttgaaccca ttacttggga agaaatgatg catgatttag gcttgaagga tgaataattt
     9901 gtataaatta gttccaacaa gacgttttat caagcaattg aaaaaattgg accgttatac
     9961 gcagaagcta attacaaact atttacaaac caatgttttg gaagatccaa gacgacacgg
    10021 aaaggctttg gttggtaatc gcgttggtca atggcgctat agaattggta attatcgagt
    10081 tatcgtacaa attgtagatg atgaattagt tgttgctact ctagaagttg gtcatcggag
    10141 agatatttat tgaattaaag ctgagtaata acaatataga aagtaaggag agtaaaaatt
    10201 tgaagaaaaa atggtttttt gcagattatt atgatacaac aattatttta cttgctttaa
    10261 tctctgttat tctggtatta cttggatttg ctgagatgat tgatttggac aatccgcctt
    10321 atagtattat tgatttagta atctggggtg tttttgtaat tgattatagt tggcgctttt
    10381 ttacgactaa aagaaaatgg cgctttattc ttgaaaatat ttttgattta ttggctattc
    10441 tccctttaaa tgctattttt acagtgtttc gattagggcg tatctttcgt ttagttaaac
    10501 taacaaaatt actgaaactg actcgtttac ttagaataat tggacttaca ggtaaattag
    10561 aaagaaaaat tagtagattc ttacggacaa atggcttgat ttatatcttg tatgttaata
    10621 tctttatcgt gctagtagga agttcaattt tatctgtagt tgaagaaaaa tccttctcag
    10681 atagtctttg gtgggctctt gtaacggtaa cgactgttgg atatggggat attgttcctg
    10741 cttccatttt tgggaaatgg ctagcagttt tactgatgct tgtcggtatt ggaacaatag
    10801 ggatgttaac aagtgctttg acgaactttt ttgtaaagga taatccagat gaacagataa
    10861 aacttgataa actccaagat gaattatcta gtcagagaat attactagag aaacaatcta
    10921 aaaagataga agaactacat aaaatgatac aagatttgat tgaaaaaaca taataaaaat
    10981 aaagatgaga aaaagtttga actgaggaga aatcaagtaa gttttgacac aatagaacgc
    11041 atattatcag gtataaaaac ttgatactat gcgttttata gagaaataaa ataaaatctg
    11101 aacaaatcaa ttaggaattt aaagcatttt ataacaacgt tttagagtga tggggtgcta
    11161 tttcaacttc aacctactat aatacagaaa aaaacaactc cctgatgatt caaggagttg
    11221 tctatagtta aattagtttt tagaagcttc ttggaattct ggatttttcc atgcttcgtc
    11281 aataatagct tgcaattctt tagcagatgc ttgcattttt tgagtttctg catcgttcaa
    11341 tggaatgttt actggacgaa tgataccatg tgcaccaaca acagctggtt gaccgataaa
    11401 gacattctca actccgtatt gaccttcttg gaatactgaa agtggaagta ctgcgttttc
    11461 atcgtcaagg attgctttag tgatacgagc aagggctact gcgataccgt agtatgttgc
    11521 accttttttg ttgatgattg tgtaggctgc atcacgaaca ccttcgaaca attcaatcaa
    11581 ttcagcttct tgaacatttt gagtgtcttt aaggaattct tcaaggttta caccagcgat
    11641 gttagcgtgt gaccaaacag cgaactcaga gtcaccgtgt tcacccatga tgtaggcgtg
    11701 cactgaacga gcatccacat ccaatttttc agcaagtgct tgacggaaac gagctgagtc
    11761 aagtgaagta cctgaaccga taacgcgttc tttagggaaa ccagagaatt tccaagttga
    11821 gtaagtcaaa acgtcaactg ggttagcagc aacaaggaag atacctttga aaccagattc
    11881 aacaacttga gttacgattg atttgttgat agcaaggttt ttacctacaa ggtcaagacg
    11941 agtttcacct ggtttttgag gtgcacctgc agtgatcaca acaaggtcag cgtctgcaca
    12001 gtcagagtat tgagctgcat agattttttt aggtgaagtg aaggcaaggg cgtgactaag
    12061 gtcaagcgca tcaccaacag ctttttcatg caattgtgga atttcgataa ttccaagctc
    12121 ttgtgcaatt ccttggttaa caagtgcaaa agcgtaagat gaacctacag caccatcacc
    12181 gacaaggata acttttttgt gttgtttagt tgaagtcatt gttttaaaca tctccttaat
    12241 tttattaggg gattttccct agacaacttc attctatcac ttttaaaaaa ctttgtcacg
    12301 aatatgcctt atagttctcg atgtaaacgt tttagtggtt tagaggctga aatagatggg
    12361 aatttatggt ataatgttgt tacttactaa ttgtgaaatg aggcatttat taatgcagga
    12421 taaaaattta gtgaatgtca atctgacaaa ggagatgaag gcaagtttta tcgactacgc
    12481 catgagtgtt atcgtagcgc gagctcttcc tgatgttcga gatggcttaa aacctgttca
    12541 ccgtcgcatt ctctacggaa tgaatgaatt gggtgtgacc ccagacaaac cccataaaaa
    12601 atctgctcgt attacagggg atgtcatggg taaatatcac ccacacgggg attcctctat
    12661 ttatgaagcc atggtccgta tggctcaatg gtggagctac cgttacatgc ttgtagatgg
    12721 tcatgggaat tttggttcca tggatggaga tagtgctgcc gctcaacgtt ataccgaggc
    12781 acgtatgagc aagattgctc tggaaatgct tcgtgatatc aacaaaaata cagttgattt
    12841 cgttgataac tatgatgcca atgaacggga acccttggtc ttgccagcgc gttttccaaa
    12901 ccttttggtt aatggagcaa ctggtatcgc ggttgggatg gcaaccaata ttccacctca
    12961 taatctgggt gaaaccattg atgcagtgaa gttggtcatg gataatcctg aagtgactac
    13021 caaggacttg atggaagtct tgcctggacc agattttcca actggtgctc ttgtcatggg
    13081 gaaatcaggt atccataagg cttatgaaac aggtaaaggt tcgattgtcc tacgttctcg
    13141 tacagagatt gaaacgacta agactggtcg tgagcgcatc gttgtaacag aatttcctta
    13201 catggtcaat aaaaccaagg tgcatgagca tattgttcgc ttggttcagg aaaaacgcat
    13261 tgagggtatc acagcagtac gtgatgagtc aaaccgtgaa ggtgttcgat ttgttattga
    13321 agtcaagcgc gacgcctcag ccaatgttat tctcaataac ctcttcaaaa tgacccaaat
    13381 gcaaaccaat tttggtttca atatgctcgc tatccaaaat ggtataccga aaattttgtc
    13441 tcttcgtcag attttggatg cttatatcga gcaccaaaaa gaagtggttg ttcgtcgtac
    13501 acgttttgat aaggaaaaag cggaagcgcg cgctcatatc ttagaaggtc tcttgattgc
    13561 gctagaccat atcgacgaag tgattcgtat catccgtgct agtgaaacgg atgcggaagc
    13621 tcaagctgag ttgatgagca agtttaagct ttctgaacgt caaagtcaag ctatccttga
    13681 tatgcgtctt cgtcgtttga caggtttgga acgcgataag attcaatctg agtatgatga
    13741 cctcttggct ctgattgcgg atttagcaga tattcttgct aagcctgaac gtgtttctca
    13801 aattatcaaa gacgaattgg atgaagttaa acgtaaattt tctgataaac gccgtacaga
    13861 gttgatggtt ggacagatct tgagtctcga ggatgaggac ttgattgaag aatcggatgt
    13921 cttgattacc ctttctaaca gaggctacat taagcgtttg gatcaggacg agttcactgc
    13981 tcaaaaacgt gggggtcgtg gtgtccaagg aacgggagtg aaagatgatg actttgttcg
    14041 tgagttagtg tcaactagca cacatgatca tctgctcttc ttcacaaaca agggacgtgt
    14101 ctatcgtctt aaaggttatg aaattcctga gtatggtcgg actgccaaag ggctaccagt
    14161 agtcaatctc ttgaaattgg atgaagacga aagtattcag acggttatca atgttgagtc
    14221 tgatcgcagt gatgatgctt atctcttctt tacaacccgt cacggtattg tgaagagaac
    14281 tagtgttaag gagtttgcca atattcgtca aaatggtctc aaagcgctga atttaaagga
    14341 tgaagatgag ttaatcaatg tcttgttggc agaaggagat atggatatta tcattggtac
    14401 caagtttggt tatgcagttc gctttaatca atcagccgtt cgtggtatga gccgtatcgc
    14461 cactggtgtg aaaggtgtta accttcgtga aggagacaca gttgttggtg ccagcttgat
    14521 tactgatcaa gatgaggttc ttattatcac agaaaaagga tatggtaagc gtacagtcgc
    14581 tactgaatac ccaacaaaag gtcgtggtgg taagggaatg cagacagcta aaattaccga
    14641 aaaaaatggc ttgctggccg gtcttatgac tgttcaaggg gatgaggatt tgatgattat
    14701 cactgataca ggtgtcatga ttcgaaccaa tcttgccaat atttcacaaa caggacgtgc
    14761 aactatggga gttaaagtaa tgcgcctgga tcaagatgct cagatagtga ctttcacaac
    14821 ggttgcggtg gcagaaaaag aagaagttgg gacagaaaac gaaacagaag gtgaagcata
    14881 atgtctcaaa aaaataataa aaagaaaaac aagcgaaaaa atctgctgac aaatatccta
    14941 gcaggatttc tgatattact gtcactggct ttgattttta atactcaaat tcgaaatatt
    15001 ttcatagtct ggaataccaa taagtatcaa gttagccagg tatcaaaaga aaaattagaa
    15061 gaaaatcagg atacagaagg caattttgac tttgattctg tcaaagctat ctcttcggaa
    15121 gctgttctaa cttctcaatg ggatgctcaa aaattaccag ttattggggg aattgcaatt
    15181 cctgaattgg aaatgaattt gccgattttt aaaggacttg ataatgttaa tctcttctac
    15241 ggagctggta caatgaaacg cgagcaagta atgggagaag gaaattatag tctagctagt
    15301 caccatatct ttggtgttga taatgctaat aaaatgttat tttctccttt agataatgct
    15361 aaaaatggca tgaagattta tctaaccgat aaaaataaag tttatactta tgaaatacgt
    15421 gaagtcaaac gtgtgacacc ggatcgtgtt gatgaagttg atgatagaga tggggtcaat
    15481 gaaatcacat tagtaacctg tgaagacctt gctgctacag aacgtattat tgtcaaaggt
    15541 gatttgaaag aaacaaaaga ttattcacaa acatctgatg aaatcctaac agctttcaat
    15601 caaccatata aacaatttta ttaatacaaa tcagtgaaat catggatttc actgattttt
    15661 taagattttc ataaaaatat agtaaaatga aataagaata ggacgaatcg
//
LOCUS       DAVHSO010000052        15611 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.052, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000052 DAVHSO010000000
VERSION     DAVHSO010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15611)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15611)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15611
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.052"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            246..2033
                     /locus_tag="VVR18_001647"
     CDS             246..2033
                     /locus_tag="VVR18_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-galactosidase"
                     /protein_id="HEU6033143.1"
                     /translation="MTRFEIRDDFYLDGKSFKILSGAIHYFRIPPEDWYHSLYNLKAL
                     GFNTVETYVAWNLHEPREGEFHFEGDLDLEKFLQIAQDLGLYAIVRPSPFICAEWEFG
                     GLPAWLLTKNMRIRSSDPAYIEAVGRYYDQLLPRLVPRLLNNGGNILMMQVENEYGSY
                     GEDKAYLRAIRQLMEECGVTCPLFTSDGPWRATLKAGTLIEEDLFVTGNFGSKAPYNF
                     SQMQEFFDEHGKKWPLMCMEFWDGWFNRWKEPIITRDPKELADAVREVLEQGSINLYM
                     FHGGTNFGFMNGCSARGTLDLPQVTSYDYDALLDEEGNPTAKYLAVKKMMATHFSEYP
                     QLEPLYKESMELDAIPLVEKVSLFETLDSLSSPVESLYPQKMEELGQSYGYLLYRTET
                     NWDAEEERLRIIDGRDRAQLYVDGQWVKTQYQTEIGEDIFYQGKKKGLSRLDILIENM
                     GRVNYGHKFLADTQRKGIRTGVCKDLHFLLNWKHYPLPLDNPEKIDFSKGWTQGQPAF
                     YAYDFTVEEPKDTYLDLSEFGKGVAFVNGQNLGRFWNVGPTLSLYIPHSYLKEGANRI
                     IIFETEGQYKEEIHLTRKPTLKHIKGENL"
     gene            2030..2506
                     /locus_tag="VVR18_001648"
     CDS             2030..2506
                     /locus_tag="VVR18_001648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEU6033144.1"
                     /translation="MTIVGCRIDGRLIHGQVANLWAGKLNVSRIMVVDDEVVNNDIEK
                     SGLKLATPPGVKLSILPVEKAAANILAGKYDSQRLFIVARKPDRFLGLVEAGVPLETL
                     NVGNMSQTPETRSITRSINVVDKDVEDFHKLAEKGVKLTAQMVPNDPISDFLSLLK"
     gene            2534..3439
                     /locus_tag="VVR18_001649"
     CDS             2534..3439
                     /locus_tag="VVR18_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEU6033145.1"
                     /translation="MIQWWQILLLTLYSAYQICDELTIVSSAGSPVFAGFITGLIMGD
                     VTTGLLIGGNLQLFVLGVGTFGGASRIDATSGAVLATAFSVSQGIDAPLAITTIAVPV
                     AALLTYFDVLGRMTTTFFAHRVDAAIERFDYKGIERNYLLGAIPWALSRALPVFFALA
                     FGGAFVQSVVDFVEAYKWVADGLTLAGRMLPGLGFAILLRYLPVKRNLHYLAMGFGLT
                     AMLTVLYSYVTGLGGAVAGIVGTLPAEVAEKIGFVNNFKGLSMIGISIVGIFLAVLHF
                     KNSQKVAVAAPSTPSESGEIEDDEF"
     gene            3426..4241
                     /locus_tag="VVR18_001650"
     CDS             3426..4241
                     /locus_tag="VVR18_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU6033146.1"
                     /translation="MTNSNYKLTKEDFNQINKRSLFTFQLGWNYERMQASGYLYMILP
                     QLRKMYGDGTPELKEMMKVHTQFFNTSPFFHTIIAGFDLAMEEKDGVGSKDAVNGIKT
                     GLMGPFAPLGDTIFGSLVPAIMGSVAATMAIAGQPWGIFLWIAVAVAYDIFRWKQLEF
                     AYKEGVNLINNMQSTLTALIDAASVLGVFMMGALVATVINFEISYKLPIGEKMIDFQD
                     ILNQIFPRLLPAIFTAFIFWLLGKKGMNSTKAIGIIIVLALALSALGHFALGM"
     gene            4248..4652
                     /locus_tag="VVR18_001651"
     CDS             4248..4652
                     /locus_tag="VVR18_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6033147.1"
                     /translation="MTKSLILVSHGRFCEELRGSTEMIMGPQDNIYTVALLPEDGPEE
                     FTAKFEAVIEGLDDFLVFADLLGGTPCNVVSRLIMEGRDIDLYAGMNLPMVIEFINAS
                     LTGADADYKSRAAESIVKVNDLLAGFDDDEDE"
     gene            4905..6071
                     /locus_tag="VVR18_001652"
     CDS             4905..6071
                     /locus_tag="VVR18_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HEU6033148.1"
                     /translation="MLHYTKEDLLELGAEITTREIYQQPDVWREAFEFYQAKREEIAA
                     FLQEIADKHDYIKVILTGAGTSAYVGDTLLPYFKEVYDERKWNFNAIATTDIVANPAT
                     YLKKDVATVLVSFARSGNSPESVATVDLAKSLVDELYQVTITCAADGKLALQAHGDDR
                     NLLLLQPVVSNDAGFAMTSSFTSMMLTALLVFDPTEFAVKSERFEVVSSLARKVLDKA
                     EDVKELVDLDFNRVIYLGAGPFFGLAHEAQLKILELTAGQVATMYESPVGFRHGPKSL
                     INEDTVVLVFGTTTDYTRKYDLDLVREVAGDQIARRVVLLSDQAFGLENVKEVVLGCG
                     GVLNDIYRVFPYIVYAQLFALLTSLKVENKPDTPSPTGTVNRVVQGVIIHEYQK"
     gene            6187..7224
                     /locus_tag="VVR18_001653"
     CDS             6187..7224
                     /locus_tag="VVR18_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose mutarotase"
                     /protein_id="HEU6033149.1"
                     /translation="MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVA
                     PDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNAS
                     NCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTYGTGGFPGNLKIWISYHLEETGAYEI
                     SYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSIAPDGVPAKTPEAN
                     RDVVKHIYNGALLKDIFAEEDEQIQLASGLDHPFALPAGHDNAGFLYDQNSGRFLLFK
                     TEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHSDLKGQVILKAGQTF
                     TSKTRYELVVK"
     gene            7431..8285
                     /locus_tag="VVR18_001654"
     CDS             7431..8285
                     /locus_tag="VVR18_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU6033150.1"
                     /translation="MTYEYKSHIYLAETVLNVKDLASQTAFYQQVIGLEILSQTETES
                     ILGLGGKVLVQLIQAQESGEVREHYGLYHLAILLPTRKALADVLKHLTDLQIPLVGGA
                     DHGYSEAIYLEDLEGNGIELYRDKPVSTWDIREDGRIIGVTEALAAQDIYELGERVES
                     FILAEGTRMGHIHLSVKDSRKSSQFYQKVLGLEDKFSVPGASWIAAGDYHHHLAVNEW
                     GGKGLASRKQGLPGLAYYVIEVAHKEELLTIAQRAQEVDAPIKWMTSSQLEITDSDGI
                     VTRIRLAR"
     gene            8435..8654
                     /locus_tag="VVR18_001655"
                     /pseudo
     CDS             8435..8654
                     /locus_tag="VVR18_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845567.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensing transcriptional repressor"
     gene            complement(8784..9170)
                     /locus_tag="VVR18_001656"
     CDS             complement(8784..9170)
                     /locus_tag="VVR18_001656"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033151.1"
                     /translation="MKIKVQTRKLAAGCSKHCFKVVDGTDEVSSKHCFKVVDGTDEVS
                     SKHCFKVVDGTDEVSSKHCFEVVDRTDEVSNHIYGKVKLTWFEEIFEEYKSPHNKTHT
                     IKVFMYCPPKVRQKKSNFWGAVHFNT"
     gene            complement(9224..9507)
                     /locus_tag="VVR18_001657"
                     /pseudo
     CDS             complement(9224..9507)
                     /locus_tag="VVR18_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450185.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
     gene            complement(9497..9658)
                     /locus_tag="VVR18_001658"
     CDS             complement(9497..9658)
                     /locus_tag="VVR18_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(FAD)-dependent dehydrogenase"
                     /protein_id="HEU6033152.1"
                     /translation="MDKKQAYIVSCHSGLRSYIAEPILKQAGFTAQNLDGAYSLYKMV
                     NPEGVEYGN"
     gene            9728..10492
                     /locus_tag="VVR18_001659"
     CDS             9728..10492
                     /locus_tag="VVR18_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
                     /protein_id="HEU6033153.1"
                     /translation="MIQKHAIPILEFDDNPQAVIMPNHEGLDLQLPKKCVYAFLGEEI
                     DRYAREVGADCVGEFVSATKTYPVYVINYKGEEVCLAQAPVGSAPAAQFMDWLIGYGV
                     EQIISTGTCGVLADIEENAFLVPVRALRDEGASYHYVAPCRYMEMQPEAIAAIERVLD
                     DRGIPYEEVMTWTTDGFYRETAEKVAYRKEEGCAVVEMECSALAAVAQLRGVLWGELL
                     FTADSLADLDQYDSRDWGSEAFNKALELSLASVHHL"
     gene            complement(10732..10884)
                     /locus_tag="VVR18_001660"
     CDS             complement(10732..10884)
                     /locus_tag="VVR18_001660"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033154.1"
                     /translation="MRTKASIRKLVTGCSKHCFEVANRTDEVSSKHCFEVADRTDEVS
                     NIYTAR"
     gene            11102..12481
                     /locus_tag="VVR18_001661"
     CDS             11102..12481
                     /locus_tag="VVR18_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000897732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEU6033155.1"
                     /translation="MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQ
                     VESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWGQIICLLLIQIGGLGLMTFIGV
                     FYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQ
                     LGWGRGLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVW
                     FDLAGHVGRKKKGRLHFHTKLVLLLTIGLLLFGTATTLFLEWNNAGTIGNLPVADKVL
                     VSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLKITTFFVLLVF
                     ARSELLGLPHANVARRTIAPRTVQKSFSVFIIFLMSFLIGLILLGITAKGNPPFIHLI
                     FETISALSTVGVTANLTPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYHPEKKDMIH
                     YMKADISIG"
     gene            12495..13160
                     /locus_tag="VVR18_001662"
     CDS             12495..13160
                     /locus_tag="VVR18_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001283913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HEU6033156.1"
                     /translation="MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEP
                     VLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIAKVK
                     SQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWA
                     GQSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVA
                     LNS"
     gene            13295..13453
                     /locus_tag="VVR18_001663"
     CDS             13295..13453
                     /locus_tag="VVR18_001663"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033157.1"
                     /translation="MKIKDQTRKLAVGCSKHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     NIYTARRR"
     gene            13515..14054
                     /locus_tag="VVR18_001664"
     CDS             13515..14054
                     /locus_tag="VVR18_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU6033158.1"
                     /translation="MKLLSIAISSYNAAAYLHYCVESLVIGGEQVGILIINDGSQDQT
                     QEIAECLASKYPNIVRAIYQENKCHGGAVNRGLAEASGRYFKVVDSDDWVDPRAYLKI
                     LETLQELESKGQEVDVFVTNFVYEKEGQSRKKSMSYDSVLPVRQIFGWDQVGNFSKGQ
                     YTMMHSLIYRTDLLRASQF"
     gene            14121..14531
                     /locus_tag="VVR18_001665"
     CDS             14121..14531
                     /locus_tag="VVR18_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
                     /protein_id="HEU6033159.1"
                     /translation="MYYLPVDFYRYLIGREDQSVNEQVMIKCIDQQLKVNRLLIDQLD
                     LSQVSHPKMREYLLNHIELTTVISSTLLNRSGTAEHLAKKRQLWTYIQQKNPEVFQAI
                     RKTMLSRLTKHSVLPDRKLSNVVYQITKSVYGFN"
     gene            14647..>15611
                     /gene="pavB"
                     /locus_tag="VVR18_001666"
     CDS             14647..>15611
                     /gene="pavB"
                     /locus_tag="VVR18_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding SSURE repeat adhesin PavB"
                     /protein_id="HEU6033160.1"
                     /translation="MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADG
                     LNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKPEGVTGNTNSLPTPTERTEVSEET
                     SPSSLDTLFEKDEEAQKNPELTDVLKETVDTADVDGTQASPAETTPEQVKGGVKENTK
                     DSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAK
                     NPALPPLEGLTKGKYFYEVDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGK
                     ADLTNLVATKNVDININGLVAKETVQKAVADNVKDSIDVPAAYLE"
BASE COUNT         4368 a         2958 c         3551 g         4734 t
ORIGIN      
        1 agcgatatag ggattgctca tattttatca atgcattcta tacaaaatta ttttaggtcc
       61 tatattccga atttaaagag cgtttgaaat gggtctaaaa atgtttgaaa ctaattgaat
      121 gtgtgtataa tagtaaaaat gcagtaaata tcccgacaat ttctattgac aattcaaaca
      181 gattggttta taattaatat aacaacaaat gaaagcgcaa actttcgcgg tcggaaggta
      241 gttttatgac acgatttgag atacgagatg atttctatct cgatggaaaa tcatttaaga
      301 ttttatctgg tgccattcat tattttagga ttcctccaga ggattggtat cattcgctct
      361 ataacttgaa ggctcttggt tttaatacgg tagagactta tgttgcttgg aatttacacg
      421 agcctcgtga aggtgagttt cattttgaag gtgatctgga tttagagaaa tttctccaaa
      481 tagcgcagga tttgggtctc tacgcaattg tgcgtccgtc tccatttatc tgtgcggaat
      541 gggaattcgg tggcttacca gcttggctct tgaccaagaa catgcgaatt cgctcatccg
      601 acccagcata tatcgaggca gttggtcgct actatgatca gttattgcca agactggtgc
      661 ctcgtttgtt gaacaatggt ggcaatattc tcatgatgca ggttgaaaat gagtatggtt
      721 cttacggaga agataaggct tacctgagag cgattcgaca gctaatggaa gagtgtggcg
      781 taacctgtcc cctctttaca tcagatggtc catggcgagc tactctgaaa gctggaacct
      841 taattgaaga ggacctcttt gtaacaggaa actttggttc taaggcacct tacaactttt
      901 cgcagatgca ggaattcttt gatgaacatg gtaagaaatg gccactcatg tgtatggagt
      961 tctgggatgg ttggttcaat cgctggaaag aaccgattat cacacgggat cctaaggaat
     1021 tggcagatgc agttcgagag gttttggaac aaggctctat caatctttac atgttccacg
     1081 gtggtacaaa ctttggtttc atgaatggtt gctcagctcg aggaactttg gacctgccac
     1141 aagttacatc ttatgattac gatgcccttc tggatgaaga aggaaatcca actgctaaat
     1201 atcttgcagt caagaagatg atggcaacac atttttcaga gtatccgcag ttggaaccac
     1261 tctacaaaga gagtatggag ttggatgcta ttccactagt tgaaaaagtt tctttgtttg
     1321 aaaccttaga tagcttgtca agtcctgtag aaagtctcta tcctcaaaag atggaggagc
     1381 tgggacaaag ttatggctac ctactttatc gaacagaaac aaactgggat gcagaagaag
     1441 aaagacttcg tatcattgat ggtcgagata gggcccagct gtatgtcgat ggtcagtggg
     1501 ttaaaactca atatcagaca gagattgggg aagatatttt ttatcaaggt aaaaagaaag
     1561 ggctatctag gttagatatc ttgatagaaa atatggggcg tgtcaactat gggcataagt
     1621 tcttagcgga tacgcaacgt aagggaattc ggacaggggt ctgtaaggat ctgcatttct
     1681 tactaaactg gaaacactat ccactcccac tagacaatcc tgagaaaatt gatttttcaa
     1741 aaggatggac tcaaggacaa ccagcctttt acgcttatga ctttacagtc gaagagccaa
     1801 aagatactta cctagacttg tctgagtttg gtaagggagt tgcctttgtc aatgggcaga
     1861 atctaggacg tttttggaac gttggcccaa ctctctcact ttatatccct catagctatc
     1921 tcaaggaagg tgccaaccgt atcattatct ttgaaacaga aggtcaatat aaagaagaga
     1981 ttcatttaac tcgtaaacct acactaaaac atataaaggg ggaaaactta tgacaattgt
     2041 aggatgccgt attgatggac gtttgatcca cggacaagta gccaatcttt gggctggaaa
     2101 actaaatgtt tcacgcatta tggttgtaga cgacgaagtt gtcaacaacg atattgaaaa
     2161 gagtggtttg aaacttgcga caccaccagg tgtgaaattg agtattttgc cagttgagaa
     2221 agctgcagcc aatattcttg ctggtaaata cgatagccaa cgtctcttta tcgtggctcg
     2281 taaaccagac cgcttccttg gtttggtaga agcaggtgta ccacttgaaa cccttaatgt
     2341 tgggaatatg tctcaaacac cagaaactcg ttctattaca cgttctatca acgtagtaga
     2401 caaggatgtg gaagacttcc acaaactggc agaaaaaggt gttaaactta ctgctcagat
     2461 ggttccaaat gatccaattt cagacttttt gagcttatta aaataggaaa aaaattttta
     2521 ggaggtcatt gttatgatac aatggtggca aattttactt ctcactttgt actcagctta
     2581 tcaaatctgt gatgagttga cgatcgtttc atctgcaggt tcccctgtat ttgctggttt
     2641 cattactggt ttaatcatgg gagatgtgac tactggttta cttatcggtg gtaacttgca
     2701 actgttcgtt cttggggttg gtactttcgg tggtgcttct cgtatcgacg caacttctgg
     2761 tgcggttctt gcgacagcct tctctgtttc acaaggaatt gatgcaccgc ttgccattac
     2821 tacaatcgct gtaccagtag cagctctctt gacttacttc gacgttcttg gtcgtatgac
     2881 tactaccttc ttcgctcacc gtgtggatgc tgcaatcgaa cgctttgact ataaaggtat
     2941 tgaacgcaac tacttgcttg gtgcgattcc gtgggctcta tctcgtgccc ttccagtctt
     3001 ctttgccctt gcttttggtg gtgcctttgt acaatcagta gtagacttcg ttgaagccta
     3061 caaatgggtt gcagatggct tgacactcgc aggacgtatg cttccaggtc ttggatttgc
     3121 aatcttgctt cgttaccttc cagttaaacg taaccttcac taccttgcta tgggatttgg
     3181 tttgacagct atgttgactg ttctttactc atatgtaaca ggtcttggtg gcgctgttgc
     3241 tggtatcgta ggtactcttc ctgctgaagt tgctgaaaaa attggtttcg tgaacaactt
     3301 caaaggtttg tctatgattg gtatttctat cgtaggtatt ttccttgcag tgcttcactt
     3361 caaaaatagc caaaaagtag ctgtagcagc accttctaca ccatcagaaa gtggggaaat
     3421 cgaagatgac gaattctaat tacaaactta caaaagaaga ttttaatcaa atcaacaaac
     3481 gtagcttgtt tactttccaa ttaggttgga actacgaacg tatgcaagct tctggttacc
     3541 tttacatgat cttacctcag ttgcgtaaaa tgtatggtga tggaactcct gaattgaaag
     3601 aaatgatgaa agttcatact caattcttca atacttcgcc attcttccat accattatcg
     3661 ctggttttga ccttgccatg gaagaaaaag atggtgtagg ttcaaaagac gccgttaacg
     3721 gtatcaagac aggtttgatg ggaccattcg ctcctcttgg ggatacaatc tttggttcac
     3781 ttgtacctgc tatcatgggg tcagtcgcag caactatggc tatcgctggc caaccttggg
     3841 ggatcttcct ttggattgca gttgcagtag cgtatgacat cttccgttgg aaacagttgg
     3901 aatttgctta caaagaaggg gttaacctta tcaacaacat gcaaagtacc ttgacagctt
     3961 tgattgacgc tgcatctgta cttggtgtct tcatgatggg tgctcttgta gcaacagtga
     4021 ttaactttga aatttcttac aagttgccaa tcggtgaaaa gatgattgat ttccaagaca
     4081 tcttgaacca aatcttccca cgtttgcttc cagcaatctt tactgccttt atcttctggt
     4141 tgcttggtaa gaaaggtatg aactctacta aagctatcgg tattattatc gtacttgctt
     4201 tggctctttc tgcccttggt cactttgcac ttggaatgta attccttatg actaaatcat
     4261 taattttggt gagccatggt cgcttctgtg aggagcttag gggtagcaca gaaatgatta
     4321 tgggtccaca agacaacatt tacacagtag ctcttcttcc agaagatggc ccagaagaat
     4381 ttactgctaa atttgaagct gttattgaag gattggatga tttcctagtt tttgcggatc
     4441 ttctcggtgg gacaccttgt aatgtggtga gtcgcttgat catggaaggt cgtgatattg
     4501 acctttacgc agggatgaat cttccaatgg tgattgaatt tatcaatgcg agccttacag
     4561 gcgcagatgc ggactacaag agccgtgctg cagaaagcat tgtgaaagtt aatgacctgt
     4621 tagcgggctt cgatgatgac gaagatgaat aatactcttc gaaaatctct tcaaactacg
     4681 tcaacgtcgc cttaccgtag gtatatgtta ctgacttcgt caatcttatc cggcaacctc
     4741 aaagcagtgc tttgagcagc ctgcggctag tttcctacag attttagttg gaactcgatt
     4801 caattcatgt gacaacgtga aaatcgttag agcattttat atagaatata catgggaatg
     4861 gagcttactc ccattcccat atttaataga aaaagaggaa ctcaatgcta cattatacaa
     4921 aagaagactt gctcgaattg ggtgcagaaa tcactacgcg tgaaatctac caacagcctg
     4981 atgtatggag agaagctttt gaattttatc aagcaaaacg tgaagaaatt gcagccttcc
     5041 tacaagaaat cgctgataaa catgactata ttaaggttat cttgacaggt gctgggactt
     5101 ctgcttatgt gggagatacc ttgctacctt attttaagga agtctatgac gaacgcaaat
     5161 ggaatttcaa tgctattgcg acaacagata tcgttgccaa tccagcaacc tatttgaaaa
     5221 aagatgtggc aactgtcctt gtgtcttttg ctcgtagtgg gaactcgcct gaaagtgtgg
     5281 cgactgttga tttggccaaa tccttggtgg atgagcttta tcaagtgacg attacttgtg
     5341 cagcagatgg taaattggct cttcaagctc acggtgatga ccgtaatctc ttgctcttgc
     5401 aaccagttgt ctctaatgat gctggatttg ccatgacttc tagctttacg tctatgatgt
     5461 tgacagctct cttggtcttt gatcctacag aatttgctgt taagtctgaa cgttttgaag
     5521 ttgtatctag tcttgcccgt aaagttttag acaaggcaga agatgtcaaa gagctcgttg
     5581 atttagactt taaccgtgtc atctatctag gcgctggtcc tttctttgga cttgctcatg
     5641 aagctcagct caagattttg gaattaactg ctggtcaagt tgcgaccatg tatgaaagcc
     5701 cagttggctt ccgtcacggt ccaaaatcac ttatcaacga agatacagtt gtcttggtct
     5761 ttggtacaac gacagactac actcgcaagt acgacttaga cttggttcgt gaagttgctg
     5821 gtgaccagat tgctcgtcgt gttgtgcttt tgagtgatca agcttttggt cttgaaaatg
     5881 tcaaagaagt ggtccttggt tgtggcggtg tcttgaatga tatttaccgt gtcttccctt
     5941 acatcgttta tgcccaactc tttgccctat tgacttcact caaggtagaa aataaaccag
     6001 atacaccgtc tcctacaggt acagtaaacc gtgtagtaca aggtgtcata attcacgaat
     6061 atcaaaagta agacagtgtt tatgaattct tgacaagagg atttgtaaat tatcagataa
     6121 accatagatt gtcagtacgc tttctatggt ttgtttgctt gagagaaata gtaaaaggag
     6181 aacagaatga aagcatacac agagcgtgta tttggaaatg ttgagggcga ggatgtcttg
     6241 gcctatcgat ttgagacaga cggtggctac caacttgagg ttatgactta tggtgcgacc
     6301 atcttgcgct atgtcgcacc tgacaaggct ggaaattttg ccaatgttat cttgggattt
     6361 gatgactttg atagttatgt aggcaatagt cccaagcatg gagcaagtgt aggtcctgta
     6421 gcgggtcgta ttgcaggtgc gacctttgag ctcaatggta agacctatga ccttgaggtt
     6481 aataatgcta gcaactgtaa tcacagtggt tcaactggtt gggattccag cttgtttgaa
     6541 gttgaagaag taagcgatca tggcttgact ctctacacag agcgtacata tgggacagga
     6601 gggttccctg gaaatctcaa gatttggatc agttatcact tggaagaaac tggtgcctat
     6661 gaaatcagct acaaggtaac gaccgatcag gatacgctgg tcaatccaac caaccacagc
     6721 tatttcaact tgtctggtga tttcacgcag acgattgacc gtcatgtctt ccaactaaac
     6781 acagagggca tttactcaat cgctcctgac ggtgttcctg ccaaaactcc agaagccaac
     6841 cgtgatgtgg tcaaacacat ctacaatggt gccttgttga aggatatctt tgcagaagaa
     6901 gatgagcaaa tccagctggc atcaggtttg gatcatccat ttgcccttcc tgcaggccat
     6961 gacaatgctg gattccttta tgaccaaaat tcaggtcgct tcctgctttt caagacagaa
     7021 gctccttgct ttgtggtcta cacagcaaac tttgtggatg aaagtgtcat cataggaggt
     7081 cagccaatgc tacagcacaa tgggattgct cttgaagcgc aagctttacc agatgccatt
     7141 cacagtgacc ttaaaggcca agtcattctt aaagctggtc aaaccttcac cagtaagaca
     7201 cgttatgaac ttgttgtgaa ataaaaaagc tggtcaaaaa gtctttaaaa ttaaaataac
     7261 gcatattgtc aggtgatgaa aagtttgata atatgcgttt tattatgaaa tgatttactt
     7321 tatcttatcc tgaaatggtg ttatttttga gttatctggc ttgactttct tgatggaaat
     7381 tatataatag ttgcaacaat aataattaca acgagaaaag aggaccattt atgacctatg
     7441 aatacaagag tcacatttat ttggcagaga cagttttaaa tgtaaaggat ttggccagtc
     7501 aaacagcctt ttatcagcaa gttattggtt tagaaatctt atctcaaact gagacagagt
     7561 ccattctagg ccttggtgga aaagtcttgg tacagctgat tcaagcacaa gagagcggag
     7621 aagtgaggga acattatggt ctttaccatt tggccattct cttgcccaca cgcaaggctt
     7681 tggctgatgt cttgaaacac ctgacagatt tacaaattcc tcttgtcggc ggtgcagacc
     7741 atggttacag tgaagctatt tacttggaag atttggaggg aaatggcatt gaactctatc
     7801 gagataagcc agtttccaca tgggatattc gagaagatgg acgcattatc ggagtgacgg
     7861 aggctcttgc ggcgcaggac atttatgagt tgggggaaag agtagagtcc tttatcctgg
     7921 cagaaggtac gagaatgggg catattcatc tttccgtcaa ggatagtcga aagtccagcc
     7981 agttttatca aaaggtgtta ggactagagg ataaattcag tgtgcctggc gctagttgga
     8041 ttgcggctgg agattaccat catcatttag cagttaacga atggggagga aaaggtctgg
     8101 cttcgcgtaa gcaaggctta ccaggtttag cctactatgt catcgaagtc gcacataaag
     8161 aagaactgtt aacgattgcc caacgagcac aagaagttga cgcaccaatc aaatggatga
     8221 catcgagcca attggaaatc acagactcag atggcatcgt gacccgtatt cgtttagcaa
     8281 ggtaaaatta ggaatttcta ataagttata agtattgcta gtttgctttt tgaacggtct
     8341 ttggtaacag aactgcgtga gctggatggg tgagaatttt gacaaagaag ctgattagag
     8401 atataatgaa gaaaaatcga gcaaggaaaa agaaatgaca aattcaaagt atattactcg
     8461 tttgaaacgt tcagagggcc agttgcgtgg gattcaaaag atgattgaag gagatcgtga
     8521 cgcaactgac agcagtgaaa tctagtgtag agcgcgtgat tgagatgata attaccgaaa
     8581 atcttactga atgtatcaat cagcccctag atgattctga agctcaaaag gaacgcctag
     8641 aaaaggctat ctgatacttg attaaacgga aataaatgaa tgttttgaga cgatatgtgc
     8701 aaaggtctat taactattag aatagtttaa tgtgagtcaa aagaagttgt aaaaaatctt
     8761 taaaattaaa aaaacgcata gtattaggta ttgaaatgta ctgcccccca aaagttagat
     8821 tttttctgtc taacttttgg ggggcagtac ataaaaacct tgatagtatg tgttttattg
     8881 tggggagatt tatactcttc gaaaatctct tcaaaccacg tcagcttcac cttgccgtag
     8941 atatggttac tgacttcgtc agttctatcc acaacctcaa aacagtgttt tgagctgact
     9001 tcgtcagttc catccacaac cttaaaacag tgttttgagc tgacttcgtc agttccatcc
     9061 acaaccttaa aacagtgttt tgagctgact tcgtcagttc catccacaac cttaaaacag
     9121 tgttttgagc agcctgcggc taacttccta gtttgcactt tgattttcat tgagtattac
     9181 ttcatctttt cctgaaattg agtttttgcc cagctcctct tgattattct acttgaccgg
     9241 gccaagcatt cataccacct tctacgttgg taacggtgag gccttgggag ctgagaaatt
     9301 ggcaggtaga tgcagagcgg actcctccgt gacaaatgac atagtattca tggtcaggtt
     9361 tgagttcttt gtagccttgc tctaaggtat ttatggaaga tttttgggtc ctgcttggaa
     9421 ttcatgtgct tcacggacat cgataagttc tagattttca ttttggtatt ttccataaaa
     9481 gtcagccatg ctgatactag tttccatatt ctactccttc tgggttaacc attttgtata
     9541 gtgaataagc gccgtcaagg ttttgggcgg taaatcctgc ttgcttgagg ataggctctg
     9601 cgatatagct gcgcaaacca ctgtggcagc tgacgatgta ggcttgtttt ttgtccagtt
     9661 catcagcttc ctccttgaca ctttgtcagt ttttgataca atagtacaaa attagaggag
     9721 gcaggctatg attcagaaac atgcgattcc tattttagag tttgatgaca atcctcaggc
     9781 ggttatcatg cccaatcacg aggggctgga cttgcagttg ccaaagaagt gtgtttatgc
     9841 atttttaggt gaggagattg accgctatgc aagggaagta ggggcggatt gtgtcggcga
     9901 attcgtttct gctaccaaga cctatccagt ctatgtcatc aactacaagg gtgaggaggt
     9961 ctgtctggct caggctcctg ttggctccgc tccagcagcc cagtttatgg attggttgat
    10021 tggctatggt gtggagcaga ttatctctac tgggacctgt ggtgtcctag ctgatataga
    10081 ggaaaatgcc tttctagtcc ctgttcgcgc tttgcgagat gagggagcca gttaccacta
    10141 tgtggcacct tgtcgttata tggaaatgca gccagaggct attgctgcta ttgagcgagt
    10201 tttggatgat agagggattc cttatgaaga agtcatgacc tggacgacag acggttttta
    10261 ccgagaaacg gctgaaaagg tggcttatcg taaggaagaa ggctgtgctg ttgtggagat
    10321 ggagtgttct gctcttgcgg cagtagctca attgcgtggg gttctctggg gtgaattgtt
    10381 gttcacagca gattctctag cggacttgga ccagtacgac agtcgtgact ggggctcgga
    10441 agcttttaat aaggcgctag aactgagttt agcaagtgtt caccaccttt agttgtactg
    10501 gcaaaggatt tgttttatca taaaatgtct agctcatact tttcaaaaat atgtttaaac
    10561 gaggtcacct tcctcttgtc ctaggcatgt tgaggttggg aaaaatcttt aaaatcagaa
    10621 aaacgtatca tatcaggtga tgaaaatttt gatactatgc gttttatgtt ggtaagattt
    10681 agagtgagat gaaatgatac tcttcgaaaa tctcttcaaa ccaggtcagc ttcaccttgc
    10741 cgtatagatg ttactgactt cgtcagttct atctgcaacc tcaaaacagt gttttgagct
    10801 gacttcgtca gttctatttg caacctcaaa acagtgtttt gagcaacctg tgactagctt
    10861 tctaattgat gccttggttc tcattgccta taatcaaaaa gagaaatttt ctcctgaaaa
    10921 gcatatagag tagctggcgt taaaagctcc tgtctcgctt ttttgaccta tagtcacatc
    10981 tatcaagtat tgttcttgcc taagctatca ataaaaaggt ggcatttttt aggcttggtg
    11041 ttagtagatt ttgccttatc ctatctaagt catttcgaac tttttatggt acaatggaaa
    11101 catgttattc aaattatcta aggaaaaaat agagctaggc ttatctcgtt tatcgccagc
    11161 ccgtcgtatt tttttgagtt ttgccttggt cattttacta ggctctcttc ttttgagctt
    11221 gccctttgtc caagttgaaa gctcacgagc gacttatttt gatcatcttt tcactgctgt
    11281 ctctgcagtc tgtgtgacag gtctctcaac ccttccagta gctcacacct ataatatatg
    11341 gggccaaata atctgtttgc ttttgattca gatcggtggt ctagggctca tgacctttat
    11401 tggggttttc tatatccaga gcaagcaaaa gcttagtctt cgtagccgtg caactattca
    11461 ggatagtttt agttatggag aaactcgatc tttgagaaag tttgtctatt ctatttttct
    11521 cacgaccttt ttggttgaga gcttaggagc tattttgctt agttttcgcc ttattcctca
    11581 acttggctgg ggacgtggtc tttttagttc catttttcta gcgatctcag ccttctgtaa
    11641 tgccggtttt gataatttag ggagcaccag tttatttgct tttcagaccg atttactggt
    11701 caatctggtg attgcaggct tgattattac aggcggcctt ggttttatgg tctggtttga
    11761 tttggctggt catgtaggaa gaaagaaaaa aggacgtctg cactttcata cgaagcttgt
    11821 actattgttg actataggtt tgttgttatt tggaacggca actactctct ttcttgagtg
    11881 gaacaatgct ggaacgattg gcaatctccc tgttgccgat aaggttttag ttagcttttt
    11941 tcaaacagtg acgatgcgaa cagctggctt ttctacgata gattatactc aggctcatcc
    12001 tgtgactctt ttaatttata tcttacagat gtttctaggt ggggcacctg gaggaacagc
    12061 tgggggactc aagattacga cattttttgt cctcttggtc tttgcacgaa gtgagcttct
    12121 aggcttgcct catgccaatg ttgcgagacg aacgattgcg ccgcgaacgg ttcaaaaatc
    12181 ctttagtgtc tttattatct ttttgatgag cttcttgata ggattgattc tgctagggat
    12241 aacagccaaa ggcaatcctc cctttatcca cctcatattt gaaaccattt cagctcttag
    12301 tacagttggt gtaacggcaa atctgactcc tgaccttggg aaattggctc tcagtgttat
    12361 catgccactt atgtttatgg gacgaattgg tcccttgacc ttgtttgtta gcttggcaga
    12421 ttaccatcca gaaaagaaag atatgattca ctatatgaaa gcagatatta gtattggtta
    12481 agaaaggaaa gagcatgtca gatcgtacga ttggaatttt gggcttggga atttttggga
    12541 gcagtgtcct agctgcccta gccaagcagg atatgaatat tatcgctatt gatgaccacg
    12601 cagagcgcat caatcagttt gagccagttt tggcgcgtgg agtgattggt gacatcacag
    12661 atgaagaatt attgagatca gcagggattg atacctgcga taccgttgta gtcgcgacag
    12721 gtgaaaatct ggagtcgagt gtgcttgcgg ttatgcactg taagagtttg ggggtaccga
    12781 ctgttattgc taaggtcaaa agtcagaccg ctaagaaagt gctagaaaag attggagctg
    12841 actcggttat ctcgccagag tatgaaatgg ggcagtctct agcacagacc attcttttcc
    12901 ataatagtgt tgatgtcttt cagttggata aaaatgtgtc tatcgtggag atgaaaattc
    12961 ctcagtcttg ggcaggtcaa agtctgagta aattagacct ccgtggcaaa tacaatctga
    13021 atattttggg tttccgagag caggaaaatt ccccattgga tgttgaattt ggaccagatg
    13081 acctcttgaa agcagatacc tatattttgg cagtcatcaa caaccagtat ttggataccc
    13141 tagtagcatt gaattcgtaa agagggatga cccctctttt ttgatgccta agatggcaaa
    13201 tagagacaga agccccttgt cttctagtaa aagttcttca aaggctggac tttatggtaa
    13261 aatagaaaga agtgacaaga gagagtaata ctcaatgaaa atcaaagatc aaactaggaa
    13321 actagctgtg ggctgctcaa aacactgttt tgaggttgtg gatagaactg acgaagtcag
    13381 ctcaaaacac tgttttgagg ttgcagatag aactgacgaa gtcagtaaca tctatacggc
    13441 aaggcgacgt tgacgcggtt tgaagagatt ttcgaagagt ataagaaaaa atcagtcccc
    13501 taaaggagca gattatgaag ttattgtcta tcgcaatttc tagctataat gcagcagcct
    13561 atcttcatta ctgtgtggag tcgctagtga ttggtggtga gcaagttggg attttgatta
    13621 tcaatgacgg gtctcaggat cagactcagg aaatcgctga gtgtttagct agcaagtatc
    13681 ctaatatcgt tagagccatc tatcaggaaa ataaatgcca tggcggtgcg gtcaatcgtg
    13741 gcttggcaga ggcttctggg cgctatttta aagtagttga cagtgatgac tgggtggatc
    13801 ctcgtgccta cttgaaaatt cttgaaacct tgcaggaact tgagagcaaa ggtcaagagg
    13861 tggatgtctt tgtgaccaat tttgtctatg aaaaggaagg gcagtctcgt aagaagagta
    13921 tgagttacga ttcagtcttg cctgttcggc agatttttgg ctgggaccag gtcggaaatt
    13981 tctccaaagg ccagtatacc atgatgcact cgctgattta tcggacagat ttgttgcgtg
    14041 ctagccagtt ctaactgcct gaacatactt tttatgtcga taatctcttt gtctttacgc
    14101 cccttcagca ggtcaagacc atgtactatc tgcctgtcga tttctatcgt tatttgattg
    14161 ggcgtgagga ccagtctgtc aatgagcaag tgatgattaa gtgcattgac cagcaactca
    14221 aggtcaatcg actcttgata gaccaacttg atttgtccca agtgagtcat cccaaaatgc
    14281 gagaatatct gctgaatcat attgaactca cgacggtgat ttccagtacc ctgctcaacc
    14341 gatctggaac agcggagcat ctggcaaaaa aacgccaatt gtggacctat attcagcaga
    14401 aaaatccaga agtctttcag gctattcgta agaccatgtt gagccgtttg accaaacatt
    14461 ctgtcttgcc agatcgcaaa ctgtccaatg tcgtctatca aatcaccaaa tctgtttatg
    14521 gatttaatta atataagtgt tttataagag ggatttaaga aaaattttaa ctttttctta
    14581 gtccttttta atttcaggag attatactag agtcatcaaa taaagaaaga ctctaaggag
    14641 aatcctatga aattcaatcc aaatcaaaga tatactcgtt ggtctattcg ccgtctcagt
    14701 gtcggtgttg cctcagttgt tgtggctagt ggcttctttg tcctagttgg tcagccaagt
    14761 tctgtacgtg ccgatgggct caatccaacc ccaggtcaag tcttacctga agagacatcg
    14821 ggaacgaaag agggtgactt atcagaaaaa ccaggagaca ccgttctcac tcaagcgaaa
    14881 cctgagggcg ttactggaaa tacgaattca cttccgacac ctacagaaag aactgaagtg
    14941 agcgaggaaa caagcccttc tagtctggat acactttttg aaaaagatga agaagctcaa
    15001 aaaaatccag agctaacaga tgtcttaaaa gaaactgtag atacagctga tgtggatggg
    15061 acacaagcaa gtccagcaga aactactcct gaacaagtaa aaggtggagt gaaagaaaat
    15121 acaaaagaca gcatcgatgt tcctgctgct tatcttgaaa aagctgaagg gaaaggtcct
    15181 ttcactgccg gtgtaaacca agtaattcct tatgaactat tcgctggtga tggtatgtta
    15241 actcgtctat tactaaaagc ttcggataat gctccttggt ctgacaatgg tactgctaaa
    15301 aatcctgctt tacctcctct tgaaggatta acaaaaggga aatacttcta tgaagtagac
    15361 ttaaatggca atactgttgg taaacaaggt caagctttaa ttgatcaact tcgcgctaat
    15421 ggtactcaaa cttataaagc tactgttaaa gtttacggaa ataaagacgg taaagctgac
    15481 ttgactaatc tagttgctac taaaaatgta gacatcaaca tcaatggatt agttgctaaa
    15541 gaaacagttc aaaaagccgt tgcagacaac gttaaggaca gtatcgatgt tccagcagcc
    15601 tacctagaaa a
//
LOCUS       DAVHSO010000053        15232 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.054, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000053 DAVHSO010000000
VERSION     DAVHSO010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15232)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15232)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15232
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.054"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(1..170)
                     /locus_tag="VVR18_001667"
                     /pseudo
     CDS             complement(1..170)
                     /locus_tag="VVR18_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(216..449)
                     /locus_tag="VVR18_001668"
     CDS             complement(216..449)
                     /locus_tag="VVR18_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEU6033161.1"
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEF
                     ILTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     gene            complement(455..1447)
                     /gene="plsX"
                     /locus_tag="VVR18_001669"
     CDS             complement(455..1447)
                     /gene="plsX"
                     /locus_tag="VVR18_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HEU6033162.1"
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIK
                     QYLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTG
                     ALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSF
                     YAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLVADESLNFIGNVEARDLMNGVA
                     DVVVADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLN
                     YSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            complement(1444..2214)
                     /gene="recO"
                     /locus_tag="VVR18_001670"
     CDS             complement(1444..2214)
                     /gene="recO"
                     /locus_tag="VVR18_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HEU6033163.1"
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQS
                     KLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADAS
                     LQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVG
                     QAFDFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQE
                     LRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            complement(2211..3380)
                     /locus_tag="VVR18_001671"
     CDS             complement(2211..3380)
                     /locus_tag="VVR18_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU6033164.1"
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTT
                     PDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYTPENEILVTIGATE
                     ALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAI
                     LEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAH
                     VSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQH
                     AAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQD
                     SFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     gene            3529..4539
                     /locus_tag="VVR18_001672"
     CDS             3529..4539
                     /locus_tag="VVR18_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family putative sulfate export transporter"
                     /protein_id="HEU6033165.1"
                     /translation="MSFLSKNGAGILVCLLISIVSWYLGGFFPVIGAPVFAIFMSMLL
                     HPFLSSYKQLDVGLTFSSKKLLQYAVILLGFGLNISQVFAVGQSSLPVILSTISIALI
                     VAYLFQRFFALDTKLATLIGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVL
                     AALIFPTLGTWLHLSNDGFALFAGTAVNDTSSVTATASAWDSLYQTNTLESATIVKLT
                     RTLAIIPITLFLSYWQSREQKNKQGLQLKKVFPLFILHFILASLLTTLLTSLGVSSSF
                     FTPLKQLSKFLIIMAMSAIGLKTNLVAMVKSSGKSIVLGAVCWIAIILTSLGMQTLIG
                     IF"
     gene            complement(4777..5214)
                     /locus_tag="VVR18_001673"
     CDS             complement(4777..5214)
                     /locus_tag="VVR18_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HEU6033166.1"
                     /translation="MSQEFINPSDGVIRQYLATSKTLAVVGLSDREETTSNRVTKEMQ
                     ARGYKIIPVNPKAAGGEILGEKAYASLAEIPVPVDIVNVYRRSEFLPDVARDFLKADA
                     KIFWAQLGLESLEAKEILRDGGCDDIVMNRCIKREHTRLIEEA"
     gene            complement(5299..7932)
                     /gene="polA"
                     /locus_tag="VVR18_001674"
     CDS             complement(5299..7932)
                     /gene="polA"
                     /locus_tag="VVR18_001674"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HEU6033167.1"
                     /translation="MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQ
                     LMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDH
                     MGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA
                     EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEG
                     IYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGK
                     FYDEMGFKQLKQALNVSSADVAEGLDFTIVDQISQDMLSEESIFHFELFGENYHTDNL
                     VGFAWSCGDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAF
                     DIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKL
                     AVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIMVKKETLLEMQAENEL
                     VIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLA
                     PIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQ
                     NIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIH
                     TSTAMRVFGIERPDNVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTY
                     FERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQ
                     GSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEIKKLVKQTMEEA
                     IQLSVPLIADENEGATWYEAK"
     gene            8188..8538
                     /locus_tag="VVR18_001675"
     CDS             8188..8538
                     /locus_tag="VVR18_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HEU6033168.1"
                     /translation="MLRHPGISPTNDLIAKKIFSNPEITCQFIRDMLDLPAKNVTILE
                     GSDIHVLLSMPYSVQDFYTSIDVLAELDNGTQVIIEIQVHHQNFFINHLWAYLCSQVN
                     QNLEKIRQREGDTH"
     gene            8753..8869
                     /locus_tag="VVR18_001676"
     CDS             8753..8869
                     /locus_tag="VVR18_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000233180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HEU6033169.1"
                     /translation="MVGVFRQQALYPATATSHYPSKSTAGLQELVRGGQENV"
     gene            8862..9095
                     /locus_tag="VVR18_001677"
     CDS             8862..9095
                     /locus_tag="VVR18_001677"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033170.1"
                     /translation="MFNQLHMREEQVLLAQDYALETARAEGLEQGLERGKVEGRAERK
                     LFAFLDIVRQGLLTSEVASQQLGMSVSEFEALL"
     gene            9222..9503
                     /locus_tag="VVR18_001678"
                     /pseudo
     CDS             9222..9503
                     /locus_tag="VVR18_001678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(9637..10605)
                     /locus_tag="VVR18_001679"
     CDS             complement(9637..10605)
                     /locus_tag="VVR18_001679"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEU6033171.1"
                     /translation="MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQV
                     NIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRK
                     ARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERR
                     GMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGK
                     TCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVL
                     DTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI"
     gene            complement(10750..11565)
                     /locus_tag="VVR18_001680"
     CDS             complement(10750..11565)
                     /locus_tag="VVR18_001680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HEU6033172.1"
                     /translation="MKKSSILFIFILLLCIGLQYETIYYTDGSRSGAEYGLMGVSIFL
                     ALFYMIPALYFLFRIGKKWELPKKVLILSLLGGMFLSGWLSSFANTYIHDLLGVLFPD
                     STFLNAFESAIVAPLVEEPLKLLPLVFVLALIPVRKLKSLFLLGIASGLGFQMIEDIG
                     YIRTDLPEGFDFTISRILERIISGIASHWTFSGLAVVGVYLLYRAYKGQKVGKKQGLI
                     FLGLALGTHFLFNSPFVELETELPLAIPVVTAIALYGFYHAYCFVEKHNELMT"
     gene            complement(11590..12087)
                     /locus_tag="VVR18_001681"
     CDS             complement(11590..12087)
                     /locus_tag="VVR18_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
                     /protein_id="HEU6033173.1"
                     /translation="MSYFEQFMQANQAYVALHGQLNLPLKPKTRVAIVTCMDSRLHVA
                     QALGLALGDAHILRNAGGRVTEDMIRSLVISQQQMGTREIVVLHHTDCGAQTFENEPF
                     QEYLKEELGVDVSDQDFLPFQDIEESVREDMQLLIESPLIPDDVIISGAIYNVDTGSM
                     TVVEL"
     gene            complement(12160..13521)
                     /gene="radA"
                     /locus_tag="VVR18_001682"
     CDS             complement(12160..13521)
                     /gene="radA"
                     /locus_tag="VVR18_001682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000336571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HEU6033174.1"
                     /translation="MAKKKATFVCQNCGYNSPKYLGRCPNCGSWSSFVEEVEVAEVKN
                     ARVSLTGEKTKPMKLAEVTSINVNRTKTEMEEFNRVLGGGVVPGSLVLIGGDPGIGKS
                     TLLLQVSTQLSQVGTVLYVSGEESAQQIKLRAERLGDIDSEFYLYAETNMQSVRAEVE
                     RIQPDFLIIDSIQTIMSPEISGVQGSVSQVREVTAELMQLAKTNNIAIFIVGHVTKEG
                     TLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNP
                     SQVFLEERLDGATGSSIVVTMEGTRPILAEVQALVTPTMFGNAKRTTTGLDFNRASLI
                     MAVLEKRAGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKDKPTNPQECFVGE
                     LGLTGEIRRVNRIEQRINEAAKLGFTKIYVPKNSLTGITLPKEIQVIGVTTIQEVLKK
                     VFA"
     gene            complement(13535..14050)
                     /locus_tag="VVR18_001683"
     CDS             complement(13535..14050)
                     /locus_tag="VVR18_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEU6033175.1"
                     /translation="MKIIFVRHGEPDYRELEERSYIGFGIDLAPLSEMGRQQVQKLSK
                     NPLLSSAEIIVSSAVTRALETASYVVCATGLPLRVEPLLHEWQVYKTGIENFETARRL
                     FLENKGELLPNSPIQYETATEMKSRFLECMSKYREHQTVVVVAHRMLMRQFVPNEKID
                     FCQVIECELEI"
     gene            complement(14052..14495)
                     /locus_tag="VVR18_001684"
     CDS             complement(14052..14495)
                     /locus_tag="VVR18_001684"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HEU6033176.1"
                     /translation="MKIRGFELVSSFTDENLLPKRETAHAAGYDLKVAVRTVVAPGEI
                     VLVPTGVKAYMQPTEVLYLYDRSSNPRKKGLVLINSVGVIDGDYYGNPGNEGHIFAQM
                     KNITDQEVVLEVGERIVQAVFATFLIADGDAADGVRTGGFGSTGH"
     gene            complement(14555..14648)
                     /gene="ffs"
                     /locus_tag="VVR18_001685"
     ncRNA           complement(14555..14648)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="VVR18_001685"
                     /product="signal recognition particle sRNA small type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00169"
     gene            complement(14681..15148)
                     /locus_tag="VVR18_001686"
     CDS             complement(14681..15148)
                     /locus_tag="VVR18_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HEU6033177.1"
                     /translation="MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRG
                     HNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNV
                     VYGAKNQKFGAAGSLYDILTDERLNHRVEVEIGILEDECAAIMQDFFRNRRKK"
BASE COUNT         4451 a         3803 c         2741 g         4237 t
ORIGIN      
        1 ttctcaacct tgcttctctc cttagatagc gcatgattac aggctttatc ttcaactgtt
       61 agcggcttga gtttgctgga tttacgtgga gtttgtgctt gaggatatat cttcatgagc
      121 ccttgataac cactgtcagc caagatttta ccagcttgtc cgatatttct catttctaaa
      181 aaccatctac ttccgttgac ttggaactcc gattgctatt ttccttgaat gattttaacc
      241 acatctccta cgttttggag ttggtcaatt tcttcatcgc tgatttcgat actaaattca
      301 tcttccagag tcaagataaa ctccatcaag tcaacagaat ccgcatccaa atcgtctttc
      361 agactcaagg attctgtcac gacaaagtcc tctccctgtc gctcttggat aatggtcaca
      421 atacggtcaa aaatttcttt ttctgtcatc tcttttattc tcctgaaaat tcacgcgcag
      481 tctgggcaac tacgtctgtt tctagcatgg tacgaatctg gcgaatcgta ctataaacag
      541 ccttggcatc gcttgagcca tgagtcttga caacaggtgc cttaacacca aacaagaccg
      601 ctccaccaac atctgaataa ttgagctgtt ttttcaaacc tctgaggctg tccttgagaa
      661 ggagggcacc tagtttcgct cgaagaccac cacctgtaat agctgtcttg agcaagccca
      721 tgattcccat agctgtccct tcgatggatt tgagcacagc gtttcccgtg aaaccatctg
      781 ccacaacaac atctgcaacg ccattcatca aatcacgcgc ttccacattt ccgataaagt
      841 tcaaactttc atcagccact agtaattcat aagtttcctt acgaagcgga tcgcccttgc
      901 tactctctgt tccgttattg agcaagccaa cacgtggttg cgcaatgcca cgaacatttt
      961 tagcatagaa ggatcctaga accgcgtatt gatggaggtg ctgggctgta ttttccgcat
     1021 tggcaccgag gtctagcatg tcaaatccct tcccatctac agtcggcaaa gtcgacataa
     1081 gcccaggacg gtcgatattc ttgatacgac ccacgatgaa gaatccagca gccaacaagg
     1141 cacctgtatt cccagccgaa aggacagcgt ctgcttcacc atctttgaca gccttggctg
     1201 ccaataccat actggcattt ttcttattcc taatagctct cgtaggttca tcatccgaat
     1261 caatcttctc atccgtatgg ataatgctga cgcgctctgt cgctgtcaga tattgcttga
     1321 ttttagcttc atctccgtaa agttgaacct cgatatctga aaagtcagat agggcttgat
     1381 tgacaccctc aacaatggcc tgaggtgcgt aatcgccccc catggcatct actgcgattt
     1441 ttttcatttc ttttcctctt ttagtaattg tccccagtct gctagggaat caataaattt
     1501 ctttgatttt aggtgaatcc caacgtactc ttcatataat tgatccataa attggcgtag
     1561 ctcttgcttg attccaggct tgagcgaaat ggtctccaaa gtctcaaaat caatagcttg
     1621 aaattgattg agcagatagg ggatattggg attgagatga caacgtctct tatcctcatg
     1681 ataatgctct ggacagaggc aggctccata tttgaaagaa aagtcaaaag cctgaccaac
     1741 ccgatggcag aagacacact cattaaaatt gaggctgatt ccaaatcgag tcaaaatttg
     1801 aatttcaaaa atattggtca aaacctgata atccaagcct gcttccatca actccaaagt
     1861 cttttgcaaa aaagcaaaca agggagcatc ctgctgattg tcctgcaaac tagcatctgc
     1921 aagagctgcc acataggtcg cataggccat gacaaagagg tcactattaa tcttgggaaa
     1981 agtcatgacc tcatgatagt cttcgatgta actgagtccg tcatcattga ttcgcaagag
     2041 aaatcgtgcc agcaccaagg gctgaataac aggcgccagc ttagactgac cagcgtgttt
     2101 gacaaaaaac atgcgtttgc caacctgctc tgtaaaaatt ttgacgagct tgtcatcctc
     2161 acgaaaattg cgattgtaaa gcaccaagcc ttgactcgtg atagactgaa tcatgcttct
     2221 ctcatgtact cctcaagtcg tttcatggct tctttgatag tctccatgct ggctgcataa
     2281 gataggcgga cgtagccttc cccgtaacgt ccaaaggctg caccagggat aaaggcaacg
     2341 gccttcttct gagcaaaatc cttcagaaaa gcaaaggagt cttgattgta gcccgctgga
     2401 attttagcaa aaatatagaa ggcaccgtct ggtttgataa tctcaaaacc aagagcagtc
     2461 attttttcga tgatatagtc ccgacgctgg atatattcct tcttcatggg ctccgcatca
     2521 tttttaccag ccgtcaaggc ttctaccgca gcatgttgcg ccatggtatt tgcggcagtg
     2581 accaagtatt ggtgactctt gattaactgg gctgtgaagg ccgcaggagc gaaaatcagc
     2641 cccaaacgcc aacctgtcat ggcatgcgat ttagacaaac cattgataat aatagcctgg
     2701 tctctcaaca tcgttcctag agacacatgg gcttcgcctg tgtaggtcaa ttctgagtaa
     2761 acctcatcac agacaacaaa aatttcgtac ttgcgtaaaa cagctgccaa ggcctctaac
     2821 tgctctcgac tgtaggtaat tcctgtcgga ttggctggat agttgagaat aaccgccttg
     2881 agcttatcac cctgctccaa aatggccttc tccaacatct caggagtcaa gacaaaacca
     2941 ttttcagtcg tatcaatctc aacaatttct gccccaacta agttaacaat cggttcatag
     3001 cctggataag caggagctgg caaaagtacc ttgtcgccct cttccaaaat agccgtcaaa
     3061 gtcgcagata aagcctctgt cgccccaatt gtaaccaaga tttcattttc aggagtatag
     3121 tccagttggt acttttcctt aacaaagtca ctggctgcct gacgtagagt cagcagacca
     3181 ctcatccctg tatagtagga ttggttctga tcaatcgctc gcttggccgc ctccttgaca
     3241 tggtctggcg ttgtaaaatc aggttccccc aaggtcaaac gcaagacccc aggaatctcc
     3301 gaaatagcct ggtcaaactg acgaatcaac gaaacttgaa ttttatctaa ctgtttatta
     3361 aagcgcttag ttaagtccat agatacctcc tactttcaaa acgtatctct attatactac
     3421 aaaagccccc cgaccgcaaa aatacattag agaatagctt tccactttct attttacttt
     3481 tcctgtttac aggtctataa tggtaacaga ttctatttgg aggtttttat gtcatttcta
     3541 tcaaaaaatg gagcaggcat cttggtctgc cttctcattt ctatcgtatc ttggtactta
     3601 ggaggattct tccctgtgat tggcgcgccc gtttttgcga tttttatgag catgctccta
     3661 catccctttc tctcgtctta taaacaactg gatgttggat tgacctttag ttccaagaaa
     3721 ttgctccagt atgccgttat cttgcttggt tttggtctca atatctctca agtcttcgca
     3781 gttgggcaat cttcactccc tgtcatcctt tccaccattt caatagcctt gattgttgcc
     3841 tacctcttcc agcgcttctt tgccctggat acaaaactgg ctaccttgat tggagtaggt
     3901 tcttctatct gtgggggttc tgccattgca gcgacagcgc ctgttatcca tgctaaggaa
     3961 aaggaagtag cccaagccat ctccgttatc tttttcttca atgtcttggc tgcgctcatc
     4021 tttccaaccc tcggcacctg gcttcatcta tccaatgacg gcttcgccct ctttgcagga
     4081 actgcggtca atgatacttc ctctgtaacc gccacagcta gcgcttggga cagtctctac
     4141 cagaccaata ccctcgaatc cgcaaccatt gtcaaactca cgcgaaccct agctatcatc
     4201 cccatcactc tctttctttc ctactggcaa agtcgcgagc aaaaaaataa gcaaggctta
     4261 caactgaaaa aagtcttccc actttttatc cttcacttca tccttgcatc gctcctaacc
     4321 acccttctga cctctctcgg tgtgtctagt agtttcttta cccctctcaa acaactctct
     4381 aaattcctca ttatcatggc catgagtgcc atcggtctca aaactaatct ggtcgctatg
     4441 gtcaaatcca gtggaaaatc cattgttctc ggagccgtct gctggattgc catcatcctc
     4501 accagccttg gtatgcagac ccttatcggc attttctaat actcttcgaa aatctcttca
     4561 aaccacgtca acgtcgcctt gccgtaggta tatgttactg acttcgtcag ttctatctgc
     4621 aacctcaaaa cggtgttttg agctgacttc gtcagtcgta tctacaacct caaaacagtg
     4681 ttttgagcag cccgcggcta gtttcctagt ttgctagttt gctctttgat tttcattgag
     4741 tataacacaa aaggtagccc atcagctacc tttttcttat gcttcctcaa tcaagcgagt
     4801 atgttctctc ttgatacagc gattcatcac gatatcatca catccaccat cacgcaaaat
     4861 ctctttcgct tctaaacttt caagtcctag ctgtgcccaa aaaatcttgg catcagcttt
     4921 gagaaaatca cgcgccacat cgggcagaaa ttcactgcga cgataaacat tgacaatatc
     4981 tacaggaaca ggaatttcag cgaggctagc ataagccttt tcacccaaga tttcgccacc
     5041 tgccgccttg ggattgactg ggatgatttt atagccccga gcctgcattt cctttgttac
     5101 tcgattgctg gttgtttctt cacggtcaga caaacccacc acagcaaggg ttttactcgt
     5161 tgcgagatac tgacgaatca cgccatcact tggattgata aattcttgac tcatagaaat
     5221 cctccttttt catcagtata gcacattttg aaaaggtttg cagaattcta ctacaaaaaa
     5281 ggaggactag cccccttttt atttagcctc gtaccaggtt gccccttcat tctcatctgc
     5341 gataagagga acactgagtt gaatggcttc ttccatggtt tgtttcacca atttttttat
     5401 ctctaccaat tcagatttag gcacttcaag gacgatttca tcgtgcactt gtaacagcat
     5461 cttagtctga taaccacctg caaccaaggc tttatccagc tgaatcatgg caatcttgag
     5521 aatatctgct gccgaaccct ggataggtga gttgatagca gttcgctccg caaaaccacg
     5581 aatattgaag ttgcgcgaat tgatatctgg caactcacgg cgacgcttaa agagggtctc
     5641 tacatagccc ttatcacgcg cctcccgcac cacttcatcc atgtagtttt taatacctgg
     5701 aaaacgttca aagtaggtat caatgtaggc tttggcttcc ttacgactaa ttcccaaatt
     5761 attagacaag ccaaagtctg aaatcccata aaccactcca aagttaactg ccttggcatt
     5821 gcgacggtca tttgcagtca cattatcagg acgctcaatg ccaaagaccc gcatggctgt
     5881 cgaagtatgg atatctgccc cctcttggaa ggccttaatc aagtgctcat ccttagaaat
     5941 atgcgccaaa acgcgcaatt caatctgtga ataatcagag ctgagtagca cactatcctc
     6001 ccactctggc acaaaagcct tccgaatcaa gcgcccttgt tccaatcggg caggaatatt
     6061 ttgcaagttt ggatccacac tagacaaacg cccggtctgg gtcaaatcct gcacatagcg
     6121 agtatgaatc tttccatcag ccaaaatcca gtcctgcaag ccaattacat aagtagattg
     6181 aatcttagca atttgacggt aatccaggat tttcttaaca atcggagcaa taggagcgag
     6241 acgctccaaa acatccactg ctgtcgaata acctgtcttg gttttcttag tgtattctag
     6301 aggaagtccc aatttctcaa agagaagcac gcccaactgc ttaggcgagt tgacattaaa
     6361 ctcctcaccg gccagctcgt aaatctcttg agtcagtttt tcaatgacaa gctcattttc
     6421 agcctgcatc tcaagcaagg tctctttctt gaccataatc ccagcaattt ccatcttggc
     6481 aaggacaaaa gccagaggtt gctccatatc ataaagaagc tctaattgcc cattttcgct
     6541 gagtttttca agtaaaatag gctctgtttc taccaaaaca gcaagtttac aagctaagtg
     6601 ttccaagaat ttctcacgtt caggaatggc ctttttaaca cccttaccgt agaaagtttc
     6661 atcatcaacc aagtaagtct gaccataaag actagcgatg gtcgcaattt cattgtcctc
     6721 cacagtcgaa aggaggtatt tagccaaacg gatgtcaaaa gcaggcgcct gcaaatccac
     6781 accaaaacgc tgcaaaagaa ctttaacctt cttaaagtca taaactctca gagatgtttt
     6841 ttctaagaaa tccttgaaaa tcgggtcttg caacagctca agcttgtctg tggcatagag
     6901 cttatcccca caagaccagg caaatccaac caaattatcc gtatggtaat tctcaccaaa
     6961 aagctcaaag tggaagatag actcttcact cagcatatct tgactgattt ggtcaacaat
     7021 agtaaaatcc aaaccctcag ccacatcagc tgacgacaca tttaaagcct gcttgagctg
     7081 tttgaatccc atctcatcgt aaaatttccc aagattttca acatctggac cactatagac
     7141 caagtcctct aaaccaatcg caatcggtgc cttggtatca atggtcgcta gtgttttaga
     7201 caaaaaggcc tgttccttgt cattgatgag attttccttc atcttagaag tcttcattcc
     7261 atcaatattt tcataaatcc cctcaagcga accatgctcc agcaagagct taatacccgt
     7321 cttttcaccg actttggtca ccccagggat attatccgac ttatcaccca tgagcgcctt
     7381 gagatcgata aactgagctg gtgtgaggcc catttcttcc atgaggtaat ctggcgtaaa
     7441 ggcctcaaac tcagccacac ctttcttgga aatttcaacc accgtatgct catccgtcag
     7501 ctgaatcaaa tccttgtccc cactgacaat ggtaatatca aaaccatcct gctctgctag
     7561 cttatccagc gtcccaatga tgtcatccgc ctcatactga gccagctcat agtgacgaat
     7621 ccccatatga tccagcaact cacgaatgaa aggaaattgc tcacgaaact catcaggagt
     7681 cttggcccga ccacccttat agtccgcata catctctgtc cggaaggtcg tctttcccgc
     7741 atcaaaagcc accaaaatat gactcggctc aacccgctcc aacaaatgac tcaacatcaa
     7801 ctgaaaacca taaatcgcat tggtatgcaa accagccgca ttcttaaaac ggtccaactg
     7861 ctgatacagc gcaaaaaacg cccgaaaagc tacagaagac ccatcaatca ataataattt
     7921 tttcttatcc atacacccat tataaaggaa agaatcaaaa aataccattg ggaagagcta
     7981 gagcaagtat ttttcaaact ttttccgaat aaatagatag agccagagaa tttagtaaac
     8041 ctagatttaa aaatgtgcta taatatagta tattgaatct ataatagtac accttgactg
     8101 ctaaaatatt tctataaatt aatttgactt tcctgataga gttattcaca tcttatttca
     8161 actcactata gaaggaggaa taggaggatt ctcagacatc cgggcatcag cccaactaat
     8221 gatttgattg ctaagaaaat attcagcaat ccagaaatca cttgtcaatt tattcgcgat
     8281 atgctggact tgccagcaaa aaatgtgacc attttggagg gaagcgatat tcacgtatta
     8341 ctctccatgc cttactcggt gcaggatttt tataccagta tagacgtctt ggcggagttg
     8401 gataacggta ctcaagtaat tattgagatt caagtccatc atcagaattt tttcatcaat
     8461 cacttgtggg cttacctgtg cagtcaggtt aatcaaaatc ttgaaaaaat tcgtcagcga
     8521 gaaggtgata ctcactagag ctacaaacac atcgctcctg tttacgccat tgctatcgtg
     8581 gatagtaatt atttctcaga tgacctggct tttcatagct ttagtatgcg cgaagacaca
     8641 acaggtgagg tattggcgat taccaacaat ggacaggaaa accatctggt taagatggca
     8701 ttcttggaat taaaaaatac agagaaacca gcaaagacaa ggttcgcaag ccatggttgg
     8761 agtttttcgg caacaagccc tttacccagc aaccgcaacg agccattacc caagcaaatc
     8821 aactgctgga ctacaagagc tggtccgagg aggacaggaa aatgtttaat caactacata
     8881 tgcgagaaga acaagtcttg ttagcacagg actatgcctt ggaaactgct agggctgaag
     8941 gccttgaaca aggactagag cgtgggaaag ttgaaggaag ggcagaaagg aaactttttg
     9001 ccttcctaga catagtacgc caaggtcttc tgacttctga ggttgccagc cagcaattag
     9061 gtatgtcagt atctgaattt gaggcactgt tgtaaaatgg ctccataata tccatagtgg
     9121 gtaaatcccc tatggatatt atggagccta ttttgtgtag aaaaaaagtc ccatatgacc
     9181 tataatgaaa agcgacaaaa caactcatta gaaagaatca tatggaacaa ttacatttta
     9241 tcacaaaatt actagacatt aaagacccta atgtccagat tttaaacatc atcaataagg
     9301 atacacacaa ggaaatcatc gccaaactgg actacgacgc cccatcttgc cctgagtgcg
     9361 gaaaccaatt gaagaaatat gactttcaaa aaccttctaa aattccttat cttgaaacga
     9421 ctggtatacc tactagaatt ctccttagaa agcgtcgatt caagtgctat cactgttcaa
     9481 aaatgatggt cgctgaaact tctgatgacg tatagtcata tttcttctct ttttattata
     9541 tcacagtttt aaatctagct ttactagatt caccgctact atccatttat tcggaaaaaa
     9601 gacgaaaaaa cctgagaatc atctcaggct tggtcattaa atttttttct caatatcgaa
     9661 aagtggagaa agtggtcgtt tttcatgaat acgtacgata gcatccccta ggagatgagc
     9721 gattgaaatc tgctcaatct tatcaatcaa acgctcttct ggcagataga tggtatccaa
     9781 aacaaccaat ttcttaatag ctgatttttg gatattgtcc gtagcaggac cagaaagaac
     9841 tgggtgcgta cagcttgcat agacttcaac agcaccagct tccgcaagag catctgccgc
     9901 atgacaaatc gttccagcgg tatcaatcat atcatcaatc aagatacaag tcttgccttc
     9961 aaccttaccg atgatgttca taacttcact agtattcatc ttatcaacgc tacgacgttt
    10021 atcaataata gcgatagatg ttttcaaaaa ttctgccaac ttacgagcac gagtcacccc
    10081 tccatggtcc gggctgacaa ccacatagtc agaaccaacc ataccacgac gctcaaaata
    10141 atctgcaatc agaggagcac ccatcaaatg atccacagga atatcaaaga atccttgaat
    10201 ttgcgcagca tgcaagtcga tggtcaataa acgatccact ccagctactt caagcatatt
    10261 tgcgacaagt tttgaagtga ttggctcacg cgctctcgcc tttctatcct gacgtgcata
    10321 cccatagtaa ggcatgacaa cattgacaga ttctgcactc gcacgcttca aagcatctac
    10381 cataatcaaa atttcaagca gattgtcatt tacaggcgaa ctagttgatt gtaggataaa
    10441 gacgtgtttc ccacggattg attcttcaat gttgacctga atctctccat ctgaaaattg
    10501 gcgaacactt gatttcccca actctatccc aatctcctgc gccacacgtt ctgccaattc
    10561 tttattagaa gaaagggcaa acagctttaa atcagaaaaa gacatgattt cctccggtat
    10621 atatgtatcg cttgtgcttt tcacaagatt ttccatctac cattgtagcg ctttttgcac
    10681 tatttttcaa tcaaaaataa aagaagggca ccatatttgt acccttgcat cattcttttg
    10741 aaaaatattc taggtcatca actcattgtg tttctcaaca aagcaataag catgataaaa
    10801 accatagaga gcaatagccg taaccactgg aatcgctaaa ggcaactctg tttccaactc
    10861 cacaaaagga gagttaaaca agaagtgagt tcccaaggct aaacctagaa aaataaggcc
    10921 ctgtttcttg ccaaccttct gtcctttata ggctctgtaa agcaagtaaa cacctactac
    10981 agctagacct gaaaaagtcc agtgagaggc aattcctgag atgatacgct ctaaaattcg
    11041 cgaaatagta aagtcaaagc cctctggcaa atccgtacga atataaccaa tatcctcaat
    11101 catttggaat cccaaaccgg aagcaattcc aagtaaaaac aaagatttta attttcgcac
    11161 aggaatcaaa gccaaaacaa aaacaagtgg caataatttc aagggttctt ctaccaaagg
    11221 agccacaata gcactttcaa aggcatttaa aaatgtacta tctgggaaaa gaacccccag
    11281 taaatcatgg atataagtat tagcaaaact agacaaccag cctgaaagga acatccctcc
    11341 caataaagac agaatcaaaa ccttctttgg caattcccat tttttcccaa tacggaagag
    11401 aaaataaaga gccggaatca tgtaaaagag agctagaaag atagaaactc ccattagtcc
    11461 atattccgca cctgacctcg aaccgtccgt atagtagatg gtttcatact gtaaaccaat
    11521 acatagcaat aaaataaaaa taaataaaat actgcttttc ttcatacact ttctttctaa
    11581 atgaagtatt tataattcta cgactgtcat acttcctgta tcaacattgt aaatggcacc
    11641 agagataatg acatcgtctg gtattagggg agactcgata agcagttgca tatcctcgcg
    11701 tacactctct tctatatctt ggaagggcaa gaagtcctgg tctgacacat ctacacctaa
    11761 ttcctctttt aaatactcct gaaaaggttc attttcaaag gtctgagcac cacagtctgt
    11821 atggtgcaat accacaatct ctcttgtccc catttgttgc tgggaaataa ctagcgaacg
    11881 aatcatgtct tcagtcactc gaccacctgc attccgcaag atatgagcat ccccaagtgc
    11941 caagcccaga gcttgcgcaa cgtgcagacg agagtccata caggtcacaa tagctactct
    12001 tgttttgggt ttaagtggca gatttaactg cccatgtagg gcaacataag cctgattggc
    12061 ttgcataaac tgttcaaaat acgacacgat tccctccttg aaaatttgat agtcaaatat
    12121 ttctcctatc ttatcatttt taagagaatt tgtcacggat tatgcaaaga cctttttcaa
    12181 gacttcctga atcgttgtca cgccaatgac ctgaatttcc ttaggcagag tgattcctgt
    12241 caaggaattc ttaggtacat aaatcttagt aaagcccagt ttagcagctt cgttgatgcg
    12301 ttgctcaata cgattcacgc gccgaatctc tcctgtcaag cccagttctc cgacaaaaca
    12361 ttcctgagga ttagttggct tgtctttgta gctcgaagca atagcaactg caacagccaa
    12421 gtcaatcgca ggttcatcca atttaacacc accagcagat ttgagatagg catcctgatt
    12481 ttgcaagaga agccctgccc gtttttccaa aacagccata atcaagctag cacggttaaa
    12541 atcaagtcct gtcgtagtac gcttggcatt tccaaacatg gtcggtgtta ccaaagcctg
    12601 aacctccgcc aaaatcggac gcgtcccttc catggttaca acgatggagg aaccagtcgc
    12661 cccatccaaa cgctcttcta ggaaaacttg actcggattg agtacctcaa ccaaaccgcc
    12721 cgactgcatc tcaaaaatcc caatctcatt agtggaacca aaacgatttt tgaccgctct
    12781 caaaatacga aaggtgtggt gacgctcccc ttcaaagtaa agcaccgtat ccaccatatg
    12841 ctccaacata cgaggcccag ccaaggttcc ttctttggtc acatgaccta cgataaagat
    12901 ggcaatgtta ttggtcttgg ccaactgcat gagttcagcg gtcacttcac gcacctgaga
    12961 aacagacccc tgcacccctg aaatctcagg agacatgatg gtctggatgg aatcaataat
    13021 gagaaagtct ggctggatac gctccacttc tgcacgaaca ctctgcatat tggtctctgc
    13081 atagagataa aactcactat caatatcacc taagcgctct gcacgtagtt taatctgctg
    13141 ggcagactcc tccccactga catagagaac tgtccccact tgggacaact gggttgagac
    13201 ttgtaggaga agggttgatt tcccaatccc aggatcccca ccgatgagga cgagacttcc
    13261 tggtaccact ccgcctccaa gcacacggtt gaattcctcc atctccgtct tggttcgatt
    13321 gacattgatg gaagtcacct cagctagttt catgggcttg gttttctcac ctgtcaagga
    13381 cacacgcgca ttcttgacct cggcaacctc aacctcttcc acaaaagaag accaagaccc
    13441 acagttgggg caacgtccca gatatttagg ggaattatac ccacaatttt gacatacaaa
    13501 tgtcgctttt ttctttgcga tgacaaacct ctttctatat ctctaactca cactcaatca
    13561 cttggcaaaa atcaatcttc tcatttggca caaactggcg catgagcatt cgatgagcaa
    13621 caactaccac agtctgatgt tctcgatact tagacataca ttctagaaac cgagacttca
    13681 tttccgtagc tgtctcatat tgaataggac tattaggaag caactccccc ttgttttcta
    13741 aaaacagtct tctagctgtt tcaaagtttt ctattcctgt tttatagacc tgccattcat
    13801 gtaataaagg ctctactctt aaaggaagac ccgtagcaca gaccacatac gaagccgttt
    13861 ctaaagctct tgtgactgca gaagatacga ttatttcagc tgacgagagt aaaggatttt
    13921 tgctcaattt ctggacttgc tgccgtccca tctcagacaa gggtgccaaa tctatcccaa
    13981 atcctatata agaacgctcc tctaactcac ggtaatctgg ctccccatga cgtacaaaga
    14041 taatcttcat tctagtgccc tgtcgatcca aatccaccag ttcgaacgcc atcagccgca
    14101 tctccatctg caattaagaa agtagcaaaa acagcctgga caatacgctc cccaacttca
    14161 agaacaacct cttggtctgt gatattcttc atctgcgcaa aaatatgccc ttcatttcca
    14221 ggatttccat aataatctcc atcaatgacc ccaactgagt taattaaaac caagcccttc
    14281 ttacgaggat ttgaagaacg atcatagagg tagagaacct cagtcggctg catataagcc
    14341 ttaacccctg tcggaaccaa gacaatctct cctggcgcaa caactgtacg cacagcaacc
    14401 tttaagtcgt aaccagccgc atgcgctgtc tcacgcttgg gcaataaatt ttcatctgta
    14461 aaactcgaaa ccaattcaaa accacgaatt ttcataattt tctcttttct attatcattt
    14521 attctagatt attctatctt atttattcgg aaaaagcacg aaaaaagagc acacaattca
    14581 aatcgcttag ggctgctgga ttcctcccct gacccgcttc acgcagaact gttgctccac
    14641 tatttattat atcacattcc tattcatttt aaaagcaaaa ttattttttc cgtctatttc
    14701 taaaaaaatc ctgcatgata gctgcgcatt catcttccaa aattcctatt tcaacctcca
    14761 cacgatgatt gagacgctca tctgtcaaga tatcgtacaa actcccagca gcgccaaatt
    14821 tctggttttt agccccatag accacatttg gaatgcgggc aagcccaatc gccccactac
    14881 acatgacaca aggttcaatg gtcacaaaaa gtgtgcaatc cagcaagcgc cagctctcct
    14941 cactcaagtt cgcatcctct atagccataa tttccgcatg cataaccgct cgctgtaatt
    15001 cctcacgcgc attatgccca cgaccaatga tttccccatc tttgacaatc acacaaccaa
    15061 ttggaatttc atcgtgttca agagcaatct cagcctctct caaagcctcc ctcataaaga
    15121 cttctttttc ttcaagcgta taatacatct cttttctctt ttcctactta tcgattttat
    15181 tattatatca tgaatcccaa cacaaaaaaa gccaccgaat gcggtgactc ta
//
LOCUS       DAVHSO010000054        15009 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.055, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000054 DAVHSO010000000
VERSION     DAVHSO010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15009)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15009)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15009
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.055"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            85..882
                     /locus_tag="VVR18_001687"
     CDS             85..882
                     /locus_tag="VVR18_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HEU6033178.1"
                     /translation="MVSSEFISKIEFACNKKESLYSQSKFKYAIRSIFAGAFLTFSTA
                     AGAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISW
                     RKTAEILLYCTLFNLIGALIAGWGFAHSAAYANLIHDSFISGVVEMKLGRSNELVLLE
                     AILANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVA
                     ADSIANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     gene            1030..1152
                     /locus_tag="VVR18_001688"
     CDS             1030..1152
                     /locus_tag="VVR18_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent transferase"
                     /protein_id="HEU6033179.1"
                     /translation="MTCDFKFETLQLHAGQVVAPATKSRAVPIYQTTSFIFDDT"
     gene            1174..2214
                     /locus_tag="VVR18_001689"
     CDS             1174..2214
                     /locus_tag="VVR18_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001231001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase"
                     /protein_id="HEU6033180.1"
                     /translation="MRKPGNIYTRITNPTTAALEGGVEALATASGMTAVTYTILALAH
                     AGDHVVAASTIYGGTFNLLKEPLPRYGITTTFVDVDNLEEVEAAIKDNTKLVLIETLG
                     NSLINIPDLEKLAEIAHKHQIPLVSDNTFAIPYLINVFSHGVDIAIHSATKFIGGHGT
                     TIGGIIVDSGRFDWTASGKFPQFVDEGPSCHNLSYTCDVGAAAFIIAVRVQLLRDTGA
                     ALSPFNAFLLLQRLETSSLRVERHVQNAETIVDFLVNHPKVEKVNYPKLADSPYHALA
                     EKYLPKDVGSIFTFHVKGGEEEARKVIDNLEIFSDLANAADAKSLVVHPATTTHGQLS
                     EKDLEAAGVTPN"
     gene            2385..3659
                     /locus_tag="VVR18_001690"
     CDS             2385..3659
                     /locus_tag="VVR18_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HEU6033181.1"
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMKQEL
                     ALAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHEALLAKDKEV
                     QLLENQLATLRLEHENQLQKTLSDLEKERDQVKNQLLLQEKENELSLASVKQNYEAQL
                     KAASEQVEFYKDFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGS
                     KGDFIFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLV
                     TMLEADNDYFNTGIVDVRHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVRE
                     QNIDITHFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQL
                     RLANNKLEDVSVKKLTRKNPTMKAKFEALKGE"
     gene            3669..4547
                     /gene="truB"
                     /locus_tag="VVR18_001691"
     CDS             3669..4547
                     /gene="truB"
                     /locus_tag="VVR18_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HEU6033182.1"
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGV
                     LPIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVVAETPVLSPLDEKLVDE
                     AIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERSERQVTIYQFERTSPISYDG
                     QLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALTLEEIAE
                     KVEAGQLDFLHPLEIGTGDLVKVFLTPEDATEVRFGRFIELDQTDKELAAFEDDKLLA
                     ILEKRGNLYKPRKVFS"
     gene            4788..5090
                     /locus_tag="VVR18_001692"
     CDS             4788..5090
                     /locus_tag="VVR18_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEU6033183.1"
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQT
                     VMANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            5198..5836
                     /gene="udk"
                     /locus_tag="VVR18_001693"
     CDS             5198..5836
                     /gene="udk"
                     /locus_tag="VVR18_001693"
                     /EC_number="2.7.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HEU6033184.1"
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYK
                     DQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQ
                     EPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQ
                     YLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            5964..7304
                     /locus_tag="VVR18_001694"
     CDS             5964..7304
                     /locus_tag="VVR18_001694"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HEU6033185.1"
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQY
                     FSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDG
                     VGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
                     PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVV
                     RAIFESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEK
                     RMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDN
                     KQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEVKRLSEALLM
                     LDTSRIVARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            7282..7494
                     /locus_tag="VVR18_001695"
     CDS             7282..7494
                     /locus_tag="VVR18_001695"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HEU6033186.1"
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKE
                     LQATLDKAEKTLVKVMQEDGTESDFE"
     gene            7491..8366
                     /locus_tag="VVR18_001696"
     CDS             7491..8366
                     /locus_tag="VVR18_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HEU6033187.1"
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRP
                     FLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFG
                     EAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
                     HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVL
                     DVTASFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQIPFE
                     TESIVSVVESLRING"
     gene            8359..9174
                     /locus_tag="VVR18_001697"
     CDS             8359..9174
                     /locus_tag="VVR18_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="HEU6033188.1"
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPG
                     EKIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQ
                     NSAKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISL
                     SLILPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQNVLESVTAMAVEA
                     GFSVLGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            9167..9598
                     /locus_tag="VVR18_001698"
     CDS             9167..9598
                     /locus_tag="VVR18_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEU6033189.1"
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRD
                     IKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVK
                     AQLIETFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            9605..11272
                     /gene="recN"
                     /locus_tag="VVR18_001699"
     CDS             9605..11272
                     /gene="recN"
                     /locus_tag="VVR18_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HEU6033190.1"
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNM
                     MLGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGR
                     SISRVNGQMVNLSVLRTIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKET
                     YQTSFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLDLNQERDK
                     LLNHKNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYY
                     VLEDISKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEY
                     NLLTGNNLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKA
                     QFQVRFSKGKFSREGNKMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKE
                     GKTSIVFDEVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKIS
                     NDHSTVSTVRLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            11274..12002
                     /locus_tag="VVR18_001700"
     CDS             11274..12002
                     /locus_tag="VVR18_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine protein phosphatase"
                     /protein_id="HEU6033191.1"
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSH
                     RVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLD
                     APVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
                     WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLH
                     GIVFTDQGMTEHHFIENDGFVAED"
     gene            12081..13904
                     /gene="lepA"
                     /locus_tag="VVR18_001701"
     CDS             12081..13904
                     /gene="lepA"
                     /locus_tag="VVR18_001701"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HEU6033192.1"
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLA
                     ACEGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVI
                     GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQ
                     VRVMDGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQD
                     TRVGDTVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQ
                     FEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMD
                     VSNPSEFPDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVN
                     VIYQIPLAEIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFI
                     VHKDFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGG
                     DVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(14243..14323)
                     /locus_tag="VVR18_001702"
                     /pseudo
     CDS             complement(14243..14323)
                     /locus_tag="VVR18_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            14497..14973
                     /locus_tag="VVR18_001703"
                     /pseudo
     CDS             14497..14973
                     /locus_tag="VVR18_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
BASE COUNT         4475 a         2733 c         3516 g         4285 t
ORIGIN      
        1 aaacttttat gaaatacaga aaacgcttcc taaaacctaa agtttgtgat ataattatca
       61 agaaaaaaga tttaggagtt tattatggtt tcttcagaat ttatttcaaa gattgaattt
      121 gcttgcaata agaaagaaag tctttatagt caaagcaaat ttaagtatgc gattcgttcg
      181 atattcgcag gtgcattttt aaccttcagt actgctgcag gtgcagttgg ggctgacttg
      241 attaataaaa ttgcaccagg tagtggacgc ttcctctttc cattcgtttt tgcttggggc
      301 ttggcctaca ttgttttttt gaatgccgag ttggtcactt caaacatgat gttcttgact
      361 gctggtagtt tcttaaaaaa aatctcttgg agaaaaacag ctgagatttt actatactgt
      421 accttgttca accttatcgg agccttgata gcagggtggg gctttgctca ttcggcagcc
      481 tatgcgaatc tgatacacga tagtttcatc tcaggtgttg ttgagatgaa gttaggccgc
      541 tcaaatgaat tggtcttgct tgaggcgatt ttggcaaata ttttcgtaaa tattgcgatt
      601 ctgtcattta ttttggtcaa agatggtggt gccaaacttt ggcttgtgtt gtcagctatt
      661 tacatgtttg tattcttaac aaacgagcac attgcggcga actttgcttc tttcgcgatt
      721 gtgaaattca gtgttgctgc ggattcaatt gccaacttcg gtgttggaaa tatgcttcgc
      781 cactggggtg tgactttcat cggaaacttt atcggaggag gcctcttgat gggtcttcca
      841 tatgccttcc tcaataaaaa cgaagatact tatgtagatt aagaaaatga gcacgattga
      901 gtcgtgcttt tttcattttc aaaataaggt aatagctatt tcttatatca aaatatagaa
      961 aactgatatt tgtaaactat aactcaaggt gctacaatat ccttaataaa atgatatgga
     1021 ggtcacctta tgacttgtga ttttaaattt gaaactctac aactacatgc tggtcaagtt
     1081 gtggctccag ctactaagtc tcgtgcagtg ccgatttatc aaacaacatc ttttattttt
     1141 gatgacacgt aggaaggtgc tgatctgttt gccttgagga aaccagggaa catttatact
     1201 cgtatcacca atcctacaac agctgccctt gaaggtggtg ttgaagcgct agcaacagca
     1261 tcaggtatga ctgcagtgac ttatacgatt ttggcgcttg cccatgctgg tgaccatgta
     1321 gtggctgctt cgactattta cggtggaacc ttcaatcttt tgaaagaacc ccttcctcgt
     1381 tatggtatca caacaacctt tgtcgatgtt gataatttgg aggaagtaga agcagctatc
     1441 aaagacaata ccaagcttgt cttgattgaa accttgggta actccttgat taatattcca
     1501 gacctggaaa aactggcaga gattgctcat aaacatcaaa tcccacttgt gtcagacaat
     1561 acttttgcaa taccttattt gattaacgtc ttctctcatg gcgttgacat tgccattcac
     1621 tctgcgacta agtttatcgg tgggcatggt acaactattg gaggaataat tgtcgatagt
     1681 ggtcgttttg actggacggc ttcagggaaa ttccctcaat ttgttgacga gggtccaagc
     1741 tgccacaatt tgagttatac ttgtgatgtg ggtgcagcag cctttattat agctgttcga
     1801 gttcaattgc ttcgtgatac aggtgcagcc ttgtcaccat tcaatgcttt cctcttgcta
     1861 caaagacttg aaacctcttc acttcgtgtg gaacgccatg tacaaaatgc tgagacaatt
     1921 gttgattttc ttgtcaacca tcctaaggta gaaaaggtaa attatccaaa acttgcagat
     1981 agtccttatc atgccttggc tgagaaatac ttgccaaaag atgtcggttc aatctttacc
     2041 ttccatgtca aaggtggcga ggaagaagca cgcaaggtca ttgataattt agaaatcttt
     2101 tctgatcttg caaacgcggc agatgctaaa tcgcttgttg tccatccagc aacaaccact
     2161 cacggtcaat tgtcagaaaa agacctagaa gcagcaggtg tcacaccaaa ctaaattcgt
     2221 ttgtcaatcg gtcttgaaaa tgtagaagat ttgattgaag acttgcgctt ggccttggaa
     2281 aaaatttaaa gtaaaagaag ataaacagtg ggcttcgact cactgttttt gattttccct
     2341 caggcatgat ataatggtta aagaagtcta gaaagaggaa cgatatgaac gaaatcaaat
     2401 gtcccaactg tggggaagtc tttacagtaa atgagagtca gtatgccgaa ctcttgtccc
     2461 aagtgagaac ggcagagttt gataaggaac tacacgatag gatgaagcag gaactggcct
     2521 tggctgagca aaaggccatg aatgagcaac agactaaact ggctcagaag gatcaagaaa
     2581 ttgcgcaatt acagagtcag atccaaaact ttgatacaga aaaagaattg gccaagaaag
     2641 aggttgaaca gacaagccat gaggctctct tggctaagga caaggaagta cagctcttag
     2701 aaaatcagtt ggctaccttg cgtttggagc atgaaaatca actgcaaaag accctttctg
     2761 acctagaaaa agaacgggat caggttaaaa accaactact tttgcaggaa aaggaaaatg
     2821 aattatcttt ggcttctgtt aagcaaaact acgaagccca gctcaaggca gctagtgaac
     2881 aagtcgagtt ttataaggat tttaaggctc aacaatctac aaaagcgatt ggggaaagcc
     2941 tagaacagta tgcagagagt gagtttaaca aggttcgtag tttcgccttt ccaaatgctt
     3001 actttgagaa ggataacaag gtctcttcgc gtgggtctaa aggggacttt atcttccgtg
     3061 agtgtgatga aaatggagtt gaaatcattt ctatcatgtt tgagatgaaa aacgaagcag
     3121 acggaacaga gaagaagcac aagaatgcag atttttacaa ggaattggac aaggaccgtc
     3181 gggagaagaa ctgtgagtat gccgttttgg tgaccatgct tgaggccgat aatgactact
     3241 ttaacacagg gattgttgac gtcagacacg agtatgaaaa aatgtatgtt gttcgtcctc
     3301 aattctttat ccaattgatt ggtctcttac gtaatgcggc gctaaattcc ctaaaataca
     3361 agcaggagtt ggccttggtt cgcgagcaaa atattgacat tacgcatttt gaggaagatt
     3421 tggatgcctt taagctagct tttgctaaga actataattc agcttcgact aactttggaa
     3481 aagctattga tgaaatcgac aaggccatca aacgcatgga agaggttaag aaattcctga
     3541 ctacatctga aaaccaactc cgtctagcta acaacaaatt ggaagatgtc tctgttaaaa
     3601 aattgacccg gaaaaatcca acaatgaaag cgaagttcga agcactgaag ggggagtaga
     3661 aagcaaaaat gaacggtatt atcaacttaa aaaaagaagc aggaatgacc tcgcatgatg
     3721 cggtttttaa actgcgtaag attttgggaa ccaagaaaat tggtcatggc ggaaccttgg
     3781 atccggatgt ggtgggtgtt ttgccgattg cggttggcaa ggcgacacgc atggtcgagt
     3841 ttatgcagga cgagggtaag atctatgagg gggaaatcac tctgggctat tccacgacga
     3901 ctgaggatgc tagtggggaa gtggtcgcag aaacccctgt tttgtctccc ttggatgaaa
     3961 agcttgttga tgaagcgatt gctagcttga ctgggcctat tacccagatt ccccctatgt
     4021 attcggcagt taaggttaat ggtcgcaagc tctatgagta tgcgcgtgct ggtcaggaag
     4081 tggagcgttc agaacgtcag gtgaccattt atcaatttga gcgaacaagt ccgatttctt
     4141 atgatggcca acttgcccga ttcacttttc gtgtaaaatg cagtaaaggg acttacatcc
     4201 gtactttgtc agttgatttg ggtgaaaagc ttggttatgc ggctcatatg tcccatttga
     4261 ctcgtactag tgctgctggc ttacaattag aagatgctct taccttggag gaaattgctg
     4321 aaaaagtaga ggctgggcaa ttagattttc tccatccttt agagattggg acaggtgacc
     4381 ttgtcaaagt tttcctaact ccagaagatg ctacagaagt tcgctttggt cgttttattg
     4441 agctagacca aacggacaaa gaactggctg cctttgaaga tgataaattg ttagccattc
     4501 tagaaaaacg gggcaatctc tataagccaa ggaaggtttt tagctagatc gtttaggaat
     4561 aaaaatcggg tgatagataa caattgcttg ataaaacccc atactaatag tagaatggtt
     4621 ttgggaatta taatattcca attgttgcga gttgtagata ctcaaataat ctatatagaa
     4681 atttagaggt gtgaaatgaa gcaacttaaa attctttcag ataaatattt agagtccatt
     4741 acaggttctg gtgggaactt aggcccagga tttggtgtga taattccatg atgcgaaatg
     4801 agtttcgaga aagggtggag caacttcttc aacaaaaaga aataaatgaa aatagtgagt
     4861 tgagtcacct gtttcgtctt gctatacaaa atttagacag aaatgaaaaa taccaaacgg
     4921 tcatggccaa tttgagtcaa gggttgtcac tttacctcat gacgcatcat taccaggcac
     4981 ctaagtctgt cattgatttt ggtttatgga ttgccaaagc tcctagccag gaaagaggga
     5041 gactggcttt cttgcagatg cttgctcaaa ccctacaggg ctttcgttaa aactgtcgaa
     5101 catcagaggg aagactctgg tgttttttgc tgatgagact ataaattttg taaaaaatgt
     5161 gatagaatag acgacggata aaataacgga ggatagcatg caaaatagac caatcattat
     5221 tggagtgaca ggtggttctg gtggtggtaa aaccagtgtt tcaagagcca ttttatcgca
     5281 ttttcctgat gaaaagattt ccatgattga gcatgattca tactacaagg atcagtctca
     5341 tttgaccttt gaagagcgtg tcaaaaccaa ctatgaccat ccttttgcct ttgatacaga
     5401 cttgatgatc gagcagatta aggaattgtt ggcagggcgt ccggtggaca tcccgaccta
     5461 cgactataca gagcatacac ggagtagcaa gacctatcgt caggagcctc aagatgtctt
     5521 tatcgttgag ggcattttgg tcttggagga caagcgtctg cgcgatttga tggatatcaa
     5581 gatttttgtg gatacggatg acgatgtgcg cattattcgt cgtatcaagc gtgatatgga
     5641 ggagcgtggc cgtagccttg atagcgttat taaccagtac ttaggtgtgg tcaaaccaat
     5701 gtaccaccag tttatcgagt caactaagcg ttatgctgat atcgtcattc ctgaaggggt
     5761 tagcaatacc gtggctatcg acctgttgac gaccaagatt gcaaagattt tggaagaagc
     5821 tcgaaacagc aaataatcac atgtggaggc cttgcctcct ttttctattt ttccctcata
     5881 atggtacata aatggagatt tttaggcata tttttggtat aataataccc atgaaagagc
     5941 aagtaaatga atagtaggtg gagatggaaa agtatttatc ggtaacaact ttgaccaagt
     6001 atctgaaaat gaaattcgat aaagacccat acttggaacg ggtctattta actggtcaag
     6061 tttccaactt tcgtaaacga cctactcacc aatatttctc cctaaaggat gaccatgcag
     6121 ttattcaagc gaccatctgg tctgggattt atcagaaatt agggtttgac ctggaagaag
     6181 gaatgaagat caatgtgatt gggcgtgtac aggtttatga accaagtggt agctactcca
     6241 tcatcattga aaaagctgag cctgatgggg ttggggcgct tgcgattcag tttgaacaac
     6301 ttaagaaaaa attgacagaa gaaggcctgt ttcaagaacg cttcaagcaa gctctgcccc
     6361 aattttctaa gagaattggg gtagtaacca gccgtagtgg agccgttatt cgagatatta
     6421 tcacgaccgt cagcaggcga ttcccaggtg ttgacatcct tctttatccg accaaggttc
     6481 aaggtgaagg ggctgcggag gaaattgcta gaaatattgc gcgtgctaat caacgggacg
     6541 atttggattt gctcattatt ggtcgtggag gtggttctat tgaggatctc tgggccttta
     6601 acgaagaaat tgtggtacga gctatttttg aatctcgttt gccagttatc tctagtgtgg
     6661 ggcatgagac ggatgtgacc ttggcagatt ttgtggcaga tcgacgcgct gcaacgccaa
     6721 cagcggcggc tgaactggca acacctgtga ccaagttgga tgtattagct catttgcaaa
     6781 atcaggaaaa acggatggta acggcagtcc gaaatgttct atctaagaaa caagaggctt
     6841 tgaaaaaatg cagtcagtct gttatcttta gacaacctga gcgcttgtat gacggttatt
     6901 tgcaacgctt ggaccaactg caactgcgtt tgaaacaaag tttgcgaact cggatttctg
     6961 ataacaaaca attagttcaa gcaagaactc atcaattagt acaattatca cctgttacca
     7021 aaatccaacg ctatcaagac cgtttaggac agttggacaa gctcttaggt agccaaatgg
     7081 cgttagttta tgacgccaag gttgctgagg tcaagcgact ttcggaagct ttgctcatgt
     7141 tggatactag ccgaatcgtg gcgcgtggtt atgctattgt caaaaaagaa gagtccgttg
     7201 tagattcggt tgagagtttg aagaaaaaag accaagtaac gcttttgatg cgagatggtc
     7261 aagtagaatt agaggttaaa gatgtcaaaa caaaagaaat ttgaggaaaa tctagcagaa
     7321 ctggaaacca ttgtccaaag tttggaaaat ggtgaaattg ctctggaaga tgcgattact
     7381 gcctttcaaa agggcatggt cttgtcaaaa gagctccaag ctacgctgga caaggctgaa
     7441 aagaccttgg tcaaggtcat gcaagaagac ggaacagaaa gtgattttga atgaaaaagc
     7501 aagaaaaatt agctcttgtc gagtcggctt tggaagattt ttatggagac cagcagtttg
     7561 cctctagttt acgggagtct gttctctatt ctattcatgc tggtggcaag cgtattcggc
     7621 cttttctctt gttagaagtt ctggaagcct tgcaggttac catcaaacct gctcacgcgc
     7681 aggtagctac tgccttggag atgattcata cagggagctt gattcacgat gaccttcctg
     7741 ctatggatga tgacgattat cgaagagggc ggttaaccaa tcacaagaaa ttcggtgaag
     7801 ctatggccat tttggctgga gatgccttat tcttagactc atatgccttg attgcgcagg
     7861 cagatttgcc aagtcagatt aaggtggact tgattgccaa cttatccctt gcttcaggta
     7921 gtctgggtat ggtggcaggg caagttttgg atatggaggg cgaacaccag cacttgtctt
     7981 tggaagaact tcagactatt catgccaata agactgggaa gttactagcc tatcccttcc
     8041 aagcggcagc tattatagct gaattgtcac ctgaaatgca ggtgaagctg aaaactgtgg
     8101 gtgaattgat tggacttgct tttcaagtca gagatgatgt actggatgtg acagctagtt
     8161 ttgaggaaat cggcaagaca cctcaaaagg atctgcaggc agaaaaatca acctatcctg
     8221 ccctgttggg cttggaagag tccattgcct tttgtaacca aaccctggat caagctaatg
     8281 aaaaattaga agaaattgcc cagcagattc cctttgaaac agaatcgatt gtaagtgtag
     8341 tagaaagttt gagaatcaat ggctaaggaa agagtggatg tactagctta taaacagggg
     8401 ttgtttgaaa cgagagagca ggccaagcga ggtgtgatgg ctggcctagt cgtagcagtc
     8461 cttaatggag aacggtttga caagccagga gagaaaattc cagatgacac cgaattaaaa
     8521 ctcaaggggg agaaactcaa gtatgtcagc cgtggtggtt tgaaactgga aaaggccttg
     8581 caggtctttg atttgtcggt ggatggcgcg actacgattg atatcggggc ctctactgga
     8641 ggttttaccg atgtcatgct acagaatagt gccaagttgg tctttgcagt cgatgttggt
     8701 accaatcagt tggcttggaa attacgccaa gacccacgag ttgtcagcat ggagcagttc
     8761 aatttccgct atgctgaaaa gactgatttc gagcaggagc cgagctttgc cagtattgat
     8821 gtgagtttca tttcccttag tctgattttg ccagccttgc accgtgtctt ggctgatcaa
     8881 ggtcaggtgg tagcacttgt caaacctcag tttgaggcag gacgtgagca gattgggaaa
     8941 aatggaatta ttcgagatgc taaggttcat cagaatgtcc ttgaatctgt aacagctatg
     9001 gcagtagagg caggtttttc agtccttggc ttggactttt ctcccatcca aggtggacat
     9061 ggaaatattg aatttttagc gtatttgaaa aaagaaaagt cagcaagcaa tcagattctt
     9121 gctgagatta aagaagcagt agagagggcg catagtcaat ttaaaaatga ataaaaaaga
     9181 aagacttgaa aaaattagaa gattggtgac agattatcaa atcggcacgc aagaagaaat
     9241 tgtagaacat ttgaaagaag caggtatcac tgccactcag gcgacggtat cccgagatat
     9301 caaagagtta ggtattgtca aaattccttt gagagacaac acctatgtct acgaattgcc
     9361 aaaatcaatc gtaaaaagtc tgcaactggc tgaagacaat atcgaatcgg ctgaattgat
     9421 ggataagatg atcaatctcc aagttattcc aggaaatacg gcttttgtaa aagctcagtt
     9481 aatcgagact tttgcagaca agatttttag ctgtttgact gatgatagct cgattttagt
     9541 cattgccaga agtggaagtc tagcagagga aatctttgaa caagtaaaaa attggtaggt
     9601 ctatatgtta cttgaaattt cgataaaaaa ctttgccatt attgaggcta tttccctcaa
     9661 ttttgaaaag gggatgactg tcctgactgg tgaaacgggt gcagggaagt cgattatcat
     9721 tgatgccatg aatatgatgt tgggagctcg tgcgacgaca gatgttattc gtcatggtgc
     9781 accaaaggca gagattgagg ggcttttctc agttgagaat agtcgtcttt tacaggaaat
     9841 ttttgatgag caaggtttag aattaggtga tgaaattatc atccgtcggg aaatcttgca
     9901 aaatggtcgt agtatcagcc gtgtaaatgg tcagatggtt aatctgtctg ttttgcgaac
     9961 tattgggcaa catcttgtag atattcatgg tcagcatgac catgaggagt taatgcgtcc
    10021 ccaactgcat atccagatgt tggatgaatt tggtgatgcc gctttttggg acttgaaaga
    10081 aacctatcaa acgagttttg atgcctatcg gaaaatgcgc aagcaggttc tggaagtcaa
    10141 gaaaaaccaa caggaacaca aggcacgtat cgaaatgttg gaatttcaaa tggcagagat
    10201 tgaggcagca aacttgcagg ctggagaaga cttggatctc aatcaagagc gagataaact
    10261 cctcaaccac aaaaatattg cggatacact gaccaatgcc tacagtatgt tggacaatga
    10321 agatttttca agtctggcca atgttcgttc agccatgaat gacatggaaa gtgtcgaaga
    10381 gtatgaccct gaataccgtg aaatttcaag ctctctgtct gagacctact atgttttaga
    10441 agacattagc aaacgtttgg aagctatcat tgaggacctt gattttgatg gcaatcgcct
    10501 catgcaggtt gagaatcgtt tggacctcct tcatactatt actcgtaagt atggtgggac
    10561 tgttgatgat gttttgcttt attttgccaa gattacggaa gaatacaatc tcttgacagg
    10621 caataatctt tcgtctgagg acatggaagc agagcttaag aagttggaag tcaatcttgt
    10681 caatttggca ggtcaacttg cttctgctcg tcataatttg gctcagcaac tcgaagctga
    10741 gattaaacaa gaactgcaag atctttatat ggaaaaagcc cagtttcagg ttcgttttag
    10801 taagggaaaa ttcagtcgtg agggaaataa aatggttgag ttttatattt caaccaaccc
    10861 tggagaagac tttaaaccct tggttaaggt tgcttctgga ggggaattat ctcgtctcat
    10921 gttagccatt aagtctgcct tttcacgtaa agaaggcaag actagcattg tctttgatga
    10981 ggtggatacg ggagtttcag gtcgtgttgc tcaagctatt gctcagaaaa ttcataaaat
    11041 tggtcagcat ggtcaggttt tggctatctc ccatttgcca caagtaattg cgattgcaga
    11101 ttatcaattc tttattgaga agattagtaa tgaccattca acggtttcga ctgttcgtct
    11161 cttgacggtc gaagagcgag tggaggaagt tgccaagatg ttggcaggtg atgatgtgac
    11221 agaagcagcc ctgacgcaag ccagagaatt gttgagaaac agggagaaat aagatgacag
    11281 attattatgt aattggagat gttcacggaa aagctgggat gctggaagac cttcttaaaa
    11341 cctgggatgg tcagacccag ttgctctttc taggtgattt gattgacaga ggtgaggata
    11401 gtcaccgtgt tcttgaaatg gtcaaggact tggtggacaa tcaaggggct atctgtttgt
    11461 ccggaaacca cgagtatatg tttttgactt ggctagatga cccagaagaa agttatgacc
    11521 attatcgtcg caatggtgga gatacaacca ttaactctat cctaggtcgt cccttggatg
    11581 caccagttga tggagtagaa gatgccaagc gggttgccgc tgaagcggca gacttggtcg
    11641 aattcattcg tcaaatgcca tttgtagtag agacagacaa gtatatcttt gttcacgcag
    11701 gtattgattt gaccttggac gactggcatg aaacaacaga ttataaaaaa gtatggctta
    11761 gaaaaccatt ccacggagct gaaaatcata ctggaaaaac cattgtcttc ggtcatacac
    11821 cggtctatgg tttgttacag caagaacgcg gtacatctga gctttggact acagaagatg
    11881 gcaagattgg aatggatgga ggagctgttt atggtggtgt ccttcacggg attgtcttta
    11941 cagaccaagg aatgacagaa caccacttta tcgaaaatga cggctttgtc gctgaagatt
    12001 agtactccta gcagggtatg gtcttgtcaa aatatcaaaa acaatttata ataaatagat
    12061 accctgaaag gaagagaatc atgaacttag aagaattgaa aaaacgacag gagaagatcc
    12121 gtaacttctc tattatcgcc catattgacc acggaaaatc aactctagca gaccgcattt
    12181 tggaaaaaac agagacggtt tcaagtcgtg aaatgcaggc ccagcttttg gatagcatgg
    12241 atctagagcg ggaacgtgga attactatta agttgaatgc catcgagttg aattacactg
    12301 caaaagatgg ggaaacttat attttccact tgattgacac accagggcac gttgacttta
    12361 cctatgaagt ttcacgttcg ctagctgcct gtgagggtgc tattttggtg gtcgatgcgg
    12421 ctcaaggaat tgaggctcaa actcttgcca acgtttatct ggctttggat aatgatttgg
    12481 aaatcatgcc tatcattaat aaaattgacc tgccggctgc agatccggag cgcgtgcgta
    12541 cagagattga agatgtgatt ggtttggatg ccagtgaagc agttttggct tctgccaagg
    12601 ctggtattgg gattgaagaa atcctcgagc aaattgtaga aaaagtacca gcaccaacgg
    12661 gtgatgtgac ggcgccactt aaggccttga ttttcgactc tgtttacgat gcttaccgtg
    12721 gggttatcct ccaagtgcgt gtcatggacg gagtggtcaa acctggtgat aagattcagc
    12781 tcatgagcaa tagtaagacc tttgatgtgg ccgaagtcgg tatttttaca ccaaaagcgg
    12841 ttggtcgtga tttccttgcg actggtgatg ttggttacat tgcggcgtct atcaagacgg
    12901 ttcaggatac tcgtgtgggt gataccgtta ccttggcaac caatcctgcg gcagaaccat
    12961 tacatggtta taagcagatg aatcctatgg tctttgcggg tctctaccca atcgaatcaa
    13021 acaagtacaa tgacctgcgt gaagcgcttg aaaaattgca actgaatgat gctagtcttc
    13081 agtttgaacc agaaacatct caggcacttg gatttggttt ccgttgtgga tttcttggac
    13141 ttctccatat ggatgttatt caggaacgtt tagagcgtga gttcaatatt gacctcatca
    13201 tgacagctcc gtctgttatt tacaaagtta atttgaccga cggtgagtct atggatgtgt
    13261 ctaacccatc tgagtttcca gacccaacta agattgcgac cattgaagag ccttatgtca
    13321 aggcgcaaat catggtacca caggagttcg tcggagcagt aatggagcta gctcagcgta
    13381 agcgtgggga ctttgtgact atggactata ttgatgataa ccgtgtcaat gttatctatc
    13441 aaattcctct tgctgaaatt gtctttgact tctttgataa acttaagtct tcgacacgtg
    13501 gttatgcaag ctttgactac gaattgtcag aatatcgccc atctaagctg gtgaaaatgg
    13561 atatccttct caatggagat aaggtggatg ccctcagctt tatcgttcac aaggactttg
    13621 cctacgaacg tgggaaactc atcgttgata aactcaagaa aatcatccct cgccaacaat
    13681 ttgaagttcc aatccaagcg gctattggac acaagattgt cgctcgtact gatatcaagg
    13741 cccttcgtaa gaacgtactt gctaaatgtt atggtggtga cgtttctcgt aagcgtaaac
    13801 tccttgaaaa acaaaaagct ggtaagaaac gcatgaaatc catcggatca gttgaagttc
    13861 cgcaagaagc cttcctcagc gtcttgagta tggatgaaga ataagttatc agaaatgcct
    13921 ttccttgttc acaggaaatt tatataagaa tcaatagtaa tgcaggctta gatggtctgc
    13981 ttttttagtt tttatactct tcgaaaatct cttcaaacca cgtcagcgtc gccttaccgt
    14041 atgtatggtt actgacttcg tcagtttcat ctacaatctc aaaaccatgt tttgagctga
    14101 cttcgtcagt ttcatctaca acctcaaaat catgttttga gctgacttcg tcagtttcat
    14161 ctacaacctc aaaaccatgt tttgagctga cttcgtcagt ttcatctaca acctcaaaac
    14221 catgttttga gctgacttcg tcagtcttat ctacaacctc aaaactgtgt tttgagtaac
    14281 ctgcggctag cttcctagtt tgctctttga ttttcattga gtattagaac agaaaaatgc
    14341 ttggagtatt tgtttgtgtg tttgttttta tataacaaac tataaacaca acaaaaatat
    14401 aaaaaaagag acaaaaaaga acagaaagta attaacaacg atttcatata gtgttatact
    14461 tatagcataa agttaatgga aagaagggaa aaccttatgg tattagatta tttctttgac
    14521 aaaaaccttg tgttttgctt agaagcggat aatcaagaat aactctttga tcaggtagca
    14581 agcttgttgg aagaacgaga aattgtcact cctacttatc gtgaagcctt gatcacgcgt
    14641 gaaaagtcat ttccaactgg tttagatatg gaatttctag gaaaggactt gccaaatgta
    14701 gcgattcctc acacagatat tgttcataat ctagctgaga aagtggtggt tgttcgatta
    14761 gaaaaaccag taacttttca caatatgata gctcctgata aggaagtaga agtatcccta
    14821 ctcttcttta tcattaacaa ttcaagttca agtcaaacaa atattctggc tcagttgatg
    14881 gactttttca caggaaatgg acatcttgaa gacctatcaa aaatttccga accagaagcc
    14941 ctttatgctt atatagatga agcaatcgct taatcttgtc tattaaaaaa taaaatcgga
    15001 ggaagtcta
//
LOCUS       DAVHSO010000055        14182 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.056, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000055 DAVHSO010000000
VERSION     DAVHSO010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14182)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14182)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14182
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.056"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..1062
                     /locus_tag="VVR18_001704"
                     /pseudo
     CDS             1..1062
                     /locus_tag="VVR18_001704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(1179..1667)
                     /locus_tag="VVR18_001705"
     CDS             complement(1179..1667)
                     /locus_tag="VVR18_001705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000883386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein kinase family protein"
                     /protein_id="HEU6033193.1"
                     /translation="MLDEKRKNYVEDKRQNFPSLPSWKMDLFSEEEKRIYFQTTCEVS
                     SKDSAINKYKMEKIIKRSNKGNVYRAIRKSDGQKVIIKQSRPFVNYDAEGEWTALDDI
                     KNEAHMLKKLADKSYTTNLTDEFYIVDDYFLVQEQVDVLNFEEFIRETEHSLNIREKN
                     TG"
     gene            complement(1661..2129)
                     /locus_tag="VVR18_001706"
                     /pseudo
     CDS             complement(1661..2129)
                     /locus_tag="VVR18_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847907.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            2678..3355
                     /locus_tag="VVR18_001707"
     CDS             2678..3355
                     /locus_tag="VVR18_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenine-N(1))-methyltransferase"
                     /protein_id="HEU6033194.1"
                     /translation="MISKRLELVASFVSQGAILLDVGSDHAYLPIELVERGQIKSAIA
                     GEVVEGPYQSAVKNVEAHGLKEKIQVRLANGLAAFEETDQVSVITIAGMGGRLIARIL
                     EEGLGKLANVERLILQPNNREDDLRIWLQDHGFQIVAESILEEAGKFYEILVVEAGQM
                     KLSASDVRFGPFLSKEVSPVFVQKWQKEAEKLEFALGQIPEKNLEERQVLVDKIQAIK
                     EVLHVSK"
     gene            3342..4139
                     /locus_tag="VVR18_001708"
     CDS             3342..4139
                     /locus_tag="VVR18_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000881127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HEU6033195.1"
                     /translation="MLASEVIQAYEAFCPQEFSMEGDSRGLQIGTLDKGIQRVMVALD
                     IREETVAEAIEKGVDLIIVKHAPIFRPIKDLLASRPQNQIYIDLIKHDIAVYVSHTNI
                     DIVENGLNDWFCQMLEIEETTYLQETGPERGIGRIGNIQPQTFWELAQQVKQVFDLDS
                     LRMVHYQENDLQKPISRVAICGGSGQSFYKDALAKGADVYITGDIYYHTAQDMLSDGL
                     LALDPGHYIEVLFVEKIAALLTQWKEKKGWELEILPSQASTNPFRHI"
     gene            4156..5259
                     /locus_tag="VVR18_001709"
     CDS             4156..5259
                     /locus_tag="VVR18_001709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HEU6033196.1"
                     /translation="MKKVAIIGAGIVGATAAYYLSRESDLEVTVFDHEQGQATKAAAG
                     IISPWFSKRRNKAWYKMARLGADFYVDLLADLEKSGQKIDFYQRSGVFLLKKDESKLE
                     ELYQLALQRREESPLIGQLAILDQASANELFPGLQGFDRLLYASGGARVDGQLLVTRL
                     LEASHVKLVKEKVTLTPLASGYQIGEEEFEQVILATGAWLGDMLEPLGYEVDVRPQKG
                     QLRDYQLVQDMEAYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDETLLQQME
                     EAALPHYPVLARVTSRAERVGIRAYTSDFSPFFGQVPELAGVYAASGLGSSGLTTGPI
                     IGYHLAQLIQDKELTLDPLNYPIENYVKRVKSE"
     gene            5260..5340
                     /locus_tag="VVR18_001710"
                     /pseudo
     CDS             5260..5340
                     /locus_tag="VVR18_001710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            5560..6579
                     /gene="galE"
                     /locus_tag="VVR18_001711"
     CDS             5560..6579
                     /gene="galE"
                     /locus_tag="VVR18_001711"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEU6033197.1"
                     /translation="MQEKILVTGGAGFIGTHTVIELIQAGHQVVVVDNLVNSNRKSLE
                     VVERITGVEIPFYEADIRDTATLRDIFKQEEPTGVIHFAGLKAVGESTRIPLAYYDNN
                     IAGTVSLLKAMEENNCKNIIFSSSATVYGDPHTVPILEDFPLSVTNPYGRTKLMLEEI
                     LTDIYKADSEWNVVLLRYFNPIGAHESGDLGENPNGIPNNLLPYVTQVAVGKLEQVQV
                     FGDDYDTEDGTGVRDYIHVVDLAKGHVAALKKIQKGSGLNVYNLGTGKGYSVLEIIQN
                     MEKAVGRPIPYRIVERRPGDIAACYSDPAKAKAELGWEAELDITQMCEDAWRWQSKHP
                     NGFED"
     gene            6581..7546
                     /locus_tag="VVR18_001712"
     CDS             6581..7546
                     /locus_tag="VVR18_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU6033198.1"
                     /translation="MMISIIVPCLNEEEVLPLFYQALEALLPDLETEIEYVFVDDGSS
                     DGTLELLKAYREQNPAVHYISFSRNFGKEAALYAGLQYATGDLVVVMDADLQDPPSML
                     FEMKNVLDKNVDLDCVGTRRTSREGEPFFRSFCAVLFYRLMQKISPVALPSGVRDFRM
                     MRRSVVDAILSLTESNRFSKGLFAWVGFKTYYLDYPNVERQAGKTSWSFRKLFFYSIE
                     GIINFSDFPLIIAFVAGLLSCFLSLLMTFFVVVRTLILGNPTSGWTSLMAVILFLGGI
                     QLLTIGILGKYISKIYLETKKRPLYLIKEKSDLPDFTEKNKVKRL"
     gene            complement(7597..7803)
                     /locus_tag="VVR18_001713"
     CDS             complement(7597..7803)
                     /locus_tag="VVR18_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HEU6033199.1"
                     /translation="MKITLIPERCIACGLCQTYSDLFDYHDNGIVRFYDDPDQLEKEI
                     SPSQDVLEAVKNCPTRALIGNQEA"
     gene            7855..8331
                     /locus_tag="VVR18_001714"
     CDS             7855..8331
                     /locus_tag="VVR18_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM domain-containing protein"
                     /protein_id="HEU6033200.1"
                     /translation="MAKEPWQEDIYDQEESRAERRHRNHGGADRMANRILTILASIFF
                     VIVVVMVIVLIYLSSGGSNRTAALKDFHDSDASVVQISSSSSSQPEQSSEPESTSSSS
                     EEAANPEGTIKVLAGEGEAAIAARAGISIAQLEALNPGHMATGSWFANPGDVIKIK"
     gene            8340..9011
                     /locus_tag="VVR18_001715"
     CDS             8340..9011
                     /locus_tag="VVR18_001715"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HEU6033201.1"
                     /translation="MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAVTYM
                     ALKNQLGVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAI
                     AAIPQVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKE
                     NIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAE
                     AEKRM"
     gene            9141..9479
                     /locus_tag="VVR18_001716"
     CDS             9141..9479
                     /locus_tag="VVR18_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HEU6033202.1"
                     /translation="MNNLPNCPKCNSEYVYEDGALLVCPECAHEWNPAEVAEVEEGLV
                     AIDANGNKLADGDTVTLIKDLKVKGAPKDLKQGTRVKNIRIVEGDHNIDCKIDGFGAM
                     KLKSEFVRKI"
     gene            9482..10111
                     /locus_tag="VVR18_001717"
     CDS             9482..10111
                     /locus_tag="VVR18_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Pr6Pr family membrane protein"
                     /protein_id="HEU6033203.1"
                     /translation="MSKHYKLVFYSRIFLFLAAFTGVYLEITRHGGFGMLLYYTVLSN
                     LLVTIFTLYLLKVMSRVGENWQRPSLLRLKGGVTMSIMITCVIYHFLLAPIATNFYTL
                     ENFLCHYIVPIWFLADTLFFDKQGQYKIWDPAVWTILPFLYMMFALFNGLVLKLNIPN
                     AKDNPFPYFFLNVNKGWNVVFKWCLIIFVAYMVAGFIFYFIKQIKRKSS"
     gene            10351..11502
                     /locus_tag="VVR18_001718"
     CDS             10351..11502
                     /locus_tag="VVR18_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6033204.1"
                     /translation="MKQFLERASILALSLVLITSFSISSALPAMFDYYQGYSKEQIEL
                     LVSLPSFGIMMMLLLNGFLEKIFPERLQISLGLLILSLSGTAPFWYQAYPFVFGTRLL
                     FGLGLGMINAKAISIISERYQGKRRIQMLGLRASTEVVGASLITLAVGQLLAFGWTAI
                     FLAYSAGFLVLPLYLLFVPYGKSKKEVKKRAKEASRLTREMKGLIFTLAIEAAVVVCT
                     NTAITIRIPSLMVERGLGDAQLSSFVLSIMQLIGIVAGVSFSFLISIFKEKLLLWSGI
                     TFGLGQIVIALSSSLWVVVAGSVLAGFAYSVVLTTVFQLVSERIPAKLLNQATSFAVL
                     GCSFGAFTTPFVLGAIGLLTHNGMLVFSILGGWLIVISIFVMYLLQKRA"
     gene            11819..12568
                     /gene="truA"
                     /locus_tag="VVR18_001719"
     CDS             11819..12568
                     /gene="truA"
                     /locus_tag="VVR18_001719"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HEU6033205.1"
                     /translation="MTRYKATISYDGYAFAGFQRQPHARSVQEEIEKTLTRLNKGQAI
                     TVHGAGRTDSGVHALGQVIHFDLPYQMDEEKLRFALDTQSPEDIDVISIELVADDFHC
                     RYAKHSKTYEFTVDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTAS
                     GTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQ
                     IDLILEKKDRQLAGPTAAPNGLYLKEIRYEE"
     gene            12558..13313
                     /locus_tag="VVR18_001720"
     CDS             12558..13313
                     /locus_tag="VVR18_001720"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009853375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEU6033206.1"
                     /translation="MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTAL
                     TEKGFEVFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGIPVVL
                     DPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLPEAELLSGQEIKTLEDMKTAAQK
                     LHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVIQGQNAGAGCTFASSIASH
                     LVKGDKLLPAVESSKAFVYRAIAQADQYGVRTI"
     gene            13310..13771
                     /locus_tag="VVR18_001721"
     CDS             13310..13771
                     /locus_tag="VVR18_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU6033207.1"
                     /translation="MKQTKTTKIALVSLLTALSVVLGYFLKIPTPTGILTLLDAGVFF
                     AAFYFGSREGAVVGGLASFLLDLLSGYPQWMFFSLVNHGLQGFFAGFKGKSQWLGLIL
                     ATIAMVGGYALGSTLMNGWAAALPEILPNFMQNMAGMIVGFILSQSIKKIK"
     gene            14025..>14182
                     /locus_tag="VVR18_001722"
     CDS             14025..>14182
                     /locus_tag="VVR18_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033208.1"
                     /translation="MKLSCDDKVQIYELRKQGYSLEKLSNKFGINNSNLRYMIKLIDR
                     YGIEFVKKG"
BASE COUNT         4169 a         2615 c         3105 g         4293 t
ORIGIN      
        1 cttaactggc tagcacaata caggaaaaac gggtatacta ttgttgagaa aacaagaggg
       61 agagtaccta aaatgggacg taagccaaaa acgagacctg aagagaggac agaattagaa
      121 catcttcaag cagaaaatga gtacctgaga gcggagaatg ccatcctaaa aaagttaaga
      181 gaactccgat tgaaggagga aaaagagaaa gaagaaagac agaaattgtt caagaattaa
      241 tgactgagtt ttcgttagct cttcttctaa aagccattaa actagctcgt tcgacctact
      301 actatcactt gaaacagcta gataaaccag ataaggacca agagcttaaa gctgaaattc
      361 aatccatttt tatcgaacac aagggaaatt atgcttatcg tcggatttat ttagaactaa
      421 gaaatcgtgg ttatctggta aatcataaaa gagttcaagg cttgatgaaa gtactcaatt
      481 tacaagctaa aatgcgacag aaacgaaaat aaaggagacg ttggtaagaa ggcagagaat
      541 ctcattcaag gccaatttga aggctctaaa acaatggaac agtgctacac agatgtgaca
      601 gaatttgcca ttccagcaag tactcaaaag ctttacttat caccagtttt agatggcttt
      661 aacagcgaaa ttatcgccta taatctttca acttcaccca acttagaaca agtacaaaca
      721 atgttggaac aggcattcaa agagaagcac tacgagaata cgattctcca tagtgaccaa
      781 ggctggcaat accgacacga ttcttatcat cggttcctag agagtaaggg aattcaagca
      841 tccatgtcac gcaagggaaa cagccaagac aacggtatga tggaatcttt ctttgggatt
      901 ctgaaatcgg aaatgtttta cggttatgag aagtcgtttc agtcgcttaa gcaattggaa
      961 caagccatta tagactatat tgattactac aacaataaga gaattaaggt aaaactaaaa
     1021 ggacttagcc ctgtgcaata cagaactaaa tccttcggat aaattaattg tctaactttt
     1081 ggggggcagt acatttttgg tatatataaa atttgtagga gctatatcta caattttata
     1141 ttcccagttt atggatgtca cttactatat tcacaatgtt atccagtgtt tttttctcta
     1201 atatttaagg agtgttctgt ttctcgaata aattcttcaa agtttaacac gtcaacttgt
     1261 tcctgaacaa gaaaataatc atccacgata taaaattcat cagttaaatt agtagtataa
     1321 cttttatcgg ctaatttttt tagcatgtga gcttcatttt ttatatcatc aagagctgtc
     1381 cattctcctt cagcatcata attcacaaaa ggtcttgact gcttgatgat tactttttgc
     1441 ccgtccgatt ttctaattgc ccgataaaca tttcctttat ttgatctctt aataattttt
     1501 tccattttgt atttatttat tgcagagtcc ttgcttgaaa cttcacatgt ggtttgaaaa
     1561 taaatccttt tttcttcttc tgaaaataaa tccattttcc agctaggaag actagggaaa
     1621 ttttgtctct tatcttctac atagttcttc cttttttcat ctagcaataa atagatgact
     1681 tttttatttt tttcatcata agcttgtttt tttaaaaaag ctccatatct ataatgaact
     1741 ggagaatgca ttccacattg atagtcagat agtatttttg gagccttaaa ttctgacagt
     1801 ctattcgtaa gattacaaat catactctta gcttcagatt ctgacttagg atatagagtt
     1861 ataaatttgt tagcagtagg gctcatttcc ctaggggaat taattttttt taattcctct
     1921 aaatttttaa caactttaaa gctacaatta tttagttggg atagtttata cacaatctta
     1981 aaaatattta cagcgtcttt tatttgggag cttatgtgta ttttccaccc ttgtgcaggc
     2041 accttatctg ataaataata gtaattccaa atatcaccct gttggaaatt tttatcacat
     2101 tttaaacatt ctttctctaa taaatccata acaaactcct aattattaaa ataggctaga
     2161 gacacagcac tagcctattc cgtaagtaaa gctacttatt ttatataaaa tataactagc
     2221 gacctgtaat taaacaagta aaagaacaat acttagggag acctgtgaca atgatatctt
     2281 cctctggaag tagttctaat tcaaacaatg tttgttccat gactgtatcc tcctgttatg
     2341 ataaattcca gaaagcatag agcaaattcg tggttcgtct gactaaattt cttatctgaa
     2401 caccaccttc aaatacaaat tttagtcaaa cttttatttt ttctaacttt ctaattatat
     2461 tctaccatgt gcttttatat gtcaagaatt ttctgaataa actgtttatt ttttattttt
     2521 tgacattttt gcaaattgtt taaaatcttt caattggatt cacttattac tttaggacat
     2581 tgaaacttct ttcgccagag gtgcttatat tactgggaag ttgaagattg aaatgtggta
     2641 taataagagg taatagagtt ttggaaagtg agagaagatg atttcaaaga gattagaatt
     2701 ggtagcttcc tttgtgtcac agggggctat tttactagat gtgggaagtg accatgctta
     2761 tctgcctatc gagttggttg agagaggcca aatcaaaagc gctattgcag gtgaggtggt
     2821 ggaaggtccc tatcagtctg cggttaaaaa tgttgaggct cacggcctaa aggagaaaat
     2881 ccaagtccgt ttagccaatg gcttggcagc ttttgaagag actgaccaag tgtctgtcat
     2941 taccattgct ggcatgggtg gtcgtttgat tgctaggatt ttagaagaag gtttggggaa
     3001 gttagctaat gtagagcgtt tgatcctcca gcccaataat cgtgaagacg acttgcgtat
     3061 ctggctacag gatcatggat tccagattgt agcagaaagc atcttagaag aagctggaaa
     3121 gttttatgag attttggtgg tggaagcagg acaaatgaag ctatcagcca gtgatgttcg
     3181 ctttggtccc ttcttgtcca aagaagtcag tccagtattt gtccaaaaat ggcaaaaaga
     3241 agctgagaag ctagagttcg ccctcggaca aatcccagaa aaaaatctgg aagaacgtca
     3301 agttctagta gataagattc aagctatcaa ggaggtgctc catgttagca agtgaagtga
     3361 tccaagctta tgaagccttt tgccctcagg aattttctat ggagggagac agccgtggtc
     3421 tgcaaattgg cactttagac aagggtatcc aaagggtcat ggttgccctc gatattcgtg
     3481 aagagacagt ggcagaggcc attgaaaagg gtgtggactt gattatcgtc aagcacgcgc
     3541 ctatctttcg tcctatcaag gacttgcttg ccagccgtcc gcaaaatcag atttacatcg
     3601 acctgattaa gcatgacatc gcagtttatg tcagccatac caatattgat atcgttgaaa
     3661 atgggctcaa tgactggttt tgtcagatgc tagaaatcga ggagacgact tatctgcagg
     3721 aaacaggtcc agaacgtgga attggacgta ttgggaatat tcagcctcag acattttggg
     3781 aattggccca acaggtcaag caagtctttg acctagatag ccttcgaatg gtgcattatc
     3841 aagagaatga tttgcagaag cctatttcaa gagtagcaat ttgtggtgga agcgggcagt
     3901 ctttctataa ggatgctttg gcaaaggggg cagatgtcta tatcactggt gatatctact
     3961 accatactgc tcaggatatg ctgtctgatg gcttgttagc attggatcca ggtcactata
     4021 tcgaagtgct ttttgtggaa aaaatcgcag cactccttac tcaatggaaa gagaaaaaag
     4081 gctgggaact agagatttta cctagtcaag catcgaccaa tcctttccgt catatctagt
     4141 tagaaagtga agacaatgaa aaaagttgcc attattggag caggaattgt gggagcaaca
     4201 gctgcctact acctctcgag agaaagtgac ctagaggtga ccgtttttga ccatgagcaa
     4261 ggtcaagcca ccaaggccgc agcaggaatt atcagtcctt ggttttccaa acgccgtaat
     4321 aaagcctggt acaagatggc gcgcttgggg gctgattttt atgtggattt attagctgat
     4381 ttagagaaat caggacaaaa aatcgacttt taccagcgtt cgggagtctt tctcttgaaa
     4441 aaggatgaat ccaagttgga agaactttat caactggccc tccagcgcag agaagaatct
     4501 cccttgatag ggcaattagc cattctggac caagcttcag ctaatgaatt attccctggt
     4561 ttgcagggat ttgaccgcct gctctatgct tctggtggag cgagagtaga tggccaactc
     4621 ttggtaactc gtctgctaga agccagtcat gtcaagctgg tcaaagaaaa agtgactctg
     4681 acaccgttag catcaggcta ccagattggt gaagaggagt ttgagcaggt tattttggcg
     4741 acgggagctt ggttggggga catgttagag cctttaggtt atgaagtaga tgttcgtcct
     4801 caaaaaggac aactacgaga ttatcagctg gtccaagaca tggaagctta ccctgttgtc
     4861 atgccagaag gggagtggga tttgattcct tttgcaggtg ggaaattgtc cttaggcgct
     4921 acccacgaaa atgacatggg atttgatttg acggtagatg aaaccttgct ccaacaaatg
     4981 gaggaggcgg ccttgcctca ttacccagtt ttagctagag tgacttcaag ggctgagcgt
     5041 gtgggaatcc gtgcctatac cagtgatttc tctcccttct ttgggcaggt gccagaattg
     5101 gcaggtgtct atgcagccag tggactaggt tcatcaggcc tcacaactgg tcctatcatt
     5161 ggttaccatc tagcccaact gatccaagac aaggagttga ccttggaccc tctaaattac
     5221 ccaattgaaa actatgtcaa acgagtaaaa agcgaataat actcaatgaa aatcaaagaa
     5281 caaactagga aactagccgc gggttactca aagcactgct ttgaggttgt ggatagaact
     5341 gacgaagtca gctcaaaaca ctgttttgag gttgtagata gaactgacga agtcagtaac
     5401 catacccatg gcaaggcgac gttgacgtgg tttgaattgg attttcgaag agtataagca
     5461 ttttactgaa attttatcag gtagtttagg atggcaaatg acattccctg tcaaaaatgg
     5521 taaaataaga aaaaataatc tgagaatcga ggaaaaaaga tgcaagaaaa gattttggta
     5581 actggtggtg ccggttttat tggaacccac actgttattg aattgatcca agcaggccat
     5641 caagttgttg tggtggataa tcttgtcaat agcaatcgta agagtttaga agttgttgaa
     5701 agaatcacag gagttgagat tcctttctat gaggcagata ttcgtgacac agctaccctc
     5761 agagatattt tcaagcagga agaaccgact ggtgtcattc actttgctgg tttgaaggct
     5821 gttggcgaat caacacgtat ccctcttgcc tactatgaca acaatatcgc tggaactgtc
     5881 agccttttga aagccatgga agaaaacaac tgtaaaaaca tcatcttcag ttcttctgcg
     5941 acagtttacg gggatccgca cacagtgccc atcttggaag atttcccact ttcagtgacc
     6001 aacccatacg gtcgtactaa gctcatgcta gaggaaattt tgactgatat ttacaaagca
     6061 gactcagaat ggaatgttgt cttgcttcgt tactttaacc caatcggagc ccatgagagt
     6121 ggtgatttgg gagaaaatcc aaacggtatt ccaaacaatc tcttgccata tgtgactcaa
     6181 gtagccgttg gaaaattaga gcaagtgcaa gtgtttggag acgattacga tacggaagat
     6241 ggaacaggtg ttcgtgacta tatccacgtt gtcgatttgg ctaagggtca cgttgcagct
     6301 ttgaaaaaaa tccaaaaagg ttcaggacta aacgtttata accttggaac tggtaaaggt
     6361 tactcagttc ttgaaattat ccaaaacatg gaaaaagcgg tgggacgtcc tattccttac
     6421 cgtatcgtag aacgtcgccc aggtgatatc gctgcctgct actcagaccc agcaaaagct
     6481 aaagcagaac tcggttggga agcagaactc gacatcaccc aaatgtgtga agacgcatgg
     6541 cgttggcaaa gcaagcatcc aaatggattt gaagactaag atgatgattt caatcatcgt
     6601 cccttgttta aacgaagagg aagtacttcc tcttttttat caggctctgg aagctttact
     6661 tccagatttg gaaacagaaa tcgagtatgt ctttgtcgat gatggatcaa gtgatgggac
     6721 cttggaactc ttaaaggcct atcgggagca aaatccggca gtccattata tttctttctc
     6781 tcgaaatttt ggcaaagaag cagcccttta tgcaggcttg caatatgcga caggagattt
     6841 ggtggtggtg atggatgcag acctccaaga tcctcctagt atgttgtttg agatgaaaaa
     6901 tgtactagac aaaaatgtag acttggactg cgttgggaca cggagaacta gtcgggaggg
     6961 agaacccttc tttcgcagtt tctgtgctgt tctcttttat cgcctcatgc aaaaaatcag
     7021 cccagtggct ctgccgtcgg gtgtccgtga ttttcgtatg atgagaaggt ctgtagtcga
     7081 tgccatttta agcttgaccg agtccaatcg tttttcaaag gggctcttcg cctgggtggg
     7141 tttcaaaacc tactatttgg actatccaaa tgtcgaaagg caggctggca agacaagttg
     7201 gagttttagg aaactctttt tctactccat tgaagggatt attaattttt cagattttcc
     7261 cttgattata gcctttgtag ctggtctcct atcttgtttt ctttctctgc tgatgacctt
     7321 ttttgttgtg gttcggaccc tcattttggg caatccgaca tctggttgga cctctctgat
     7381 ggctgttatt ctctttcttg gaggcattca actcttgacc attgggattc tcggcaagta
     7441 tatcagtaag atttatttag agactaaaaa aagaccactt tatcttatca aagaaaaaag
     7501 tgaccttcct gattttacag aaaaaaataa agtgaaaaga ctataatttt acatggaaat
     7561 gtgctaaact agagggagtg gattatcgcc attgatttag gcttcctggt ttccaatcag
     7621 ggcgcgagtt gggcaatttt taacagcctc taagacatcc tgactaggag aaatttcttt
     7681 ttccagttgg tcagggtcat cgtaaaaacg cacgattcca ttatcgtggt aatcaaataa
     7741 atcagaataa gtttggcaaa gcccacaggc gatacatcgt tcaggtataa gtgtgatttt
     7801 catgttcata tttatattgt aataagaaaa gtaaaaaaaa acaaggagta aggtatggca
     7861 aaagaaccgt ggcaagaaga tatctatgat caagaagaat caagagcaga gcgtcggcat
     7921 cgaaaccacg gaggggctga taggatggct aatcgtattt tgacgatcct agctagtatt
     7981 ttctttgtaa ttgtggtggt gatggtcatc gttctcatct atctatcatc ggggggaagt
     8041 aatcgcacag cagccttaaa agactttcat gattctgatg caagtgtagt acaaatctca
     8101 tcttcaagca gttctcagcc tgagcagagt tcagagccag aatctacttc tagtagttca
     8161 gaagaagctg ctaatcctga aggaacgatt aaagttctcg caggagaagg ggaagcagct
     8221 attgccgctc gtgcaggaat ctccattgct cagttagagg ccttgaatcc tgggcacatg
     8281 gctacaggat cttggtttgc taatccaggt gatgttataa aaataaaata ggagccgata
     8341 tgaaaacaat tcaaattgct attgatggtc ctgcttccag cggtaagagt acggtcgcaa
     8401 agattattgc taaggatttt ggattcacct accttgatac aggagctatg tatcgtgcag
     8461 tgacctatat ggctcttaag aaccaattag gagttgaaga agtcgaagcc cttctagcct
     8521 tgttggacca gcatccaatc agctttggac gttcagaaac tggagaccag cttgtttttg
     8581 taggagatgt ggatattacc catcctatcc gtgaaaatga agtgaccaat catgtttctg
     8641 ctattgcagc aattcctcaa gtgcgtgaga aactagtttc tctccaacaa gaaattgccc
     8701 agcaaggcgg gattgttatg gatggtcgcg atattggaac tgttgtattg ccgcaagcag
     8761 aattgaaaat tttcctagta gcttctgttg atgagagagc agagcgtcgt tacaaggaaa
     8821 atattgccaa gggaattgaa acagaccttg aaaccctaaa aaaggaaatt gctgcgcgtg
     8881 actacaagga tagtcatcgt gagacttctc ctctcaaaca agcagaggat gctgtctacc
     8941 ttgatacaac tggtttgaac attcaagaag tagttgaaaa aatcaaagca gaagctgaaa
     9001 aaagaatgta aatgtagaaa agccgataga ttgatatcgg ttttttctaa atttgtcaaa
     9061 atgctgattt tagggtataa tagttgctgt tcgagaaatt ttgattttca aagaatagtg
     9121 aatgatgata aggagaaatc atgaacaatt taccaaattg tccaaaatgt aactcagagt
     9181 atgtctacga agacggtgcc ctactggttt gcccagagtg tgctcatgag tggaatcctg
     9241 ctgaagttgc agaagtagaa gaaggtcttg tcgctatcga tgccaacgga aataaattgg
     9301 ctgatggtga tacagtaact ctcatcaagg acttgaaagt aaaaggtgcg ccaaaagatt
     9361 tgaaacaagg gacgcgcgtg aaaaatatcc gcatcgtaga aggcgaccac aatatcgact
     9421 gtaagattga tggttttggt gccatgaaac ttaaatcaga gtttgtgagg aagatttaag
     9481 catgtcaaaa cactataaac ttgtatttta tagccgtatc ttcttgtttc tagcggcttt
     9541 tacgggagtt tatcttgaaa ttactaggca tggtggtttt gggatgcttc tctattacac
     9601 ggttctgtcc aacctcttgg taactatttt taccctttat cttctaaagg ttatgagccg
     9661 tgtaggtgaa aattggcaaa ggccaagtct cttgcgctta aaaggtgggg tcaccatgag
     9721 tatcatgatt acctgtgtga tttaccattt cctcttggcg cccattgcga ctaatttcta
     9781 taccctagaa aatttccttt gccactatat cgttcccatc tggtttttag cggataccct
     9841 cttttttgac aaacagggtc aatacaagat ttgggatcca gcagtgtgga ccattttacc
     9901 ctttctgtat atgatgtttg ctctttttaa tggcttggtt ctaaaactca atattccaaa
     9961 tgccaaggat aatcctttcc cttacttctt tttgaatgtg aacaagggtt ggaatgttgt
    10021 gtttaagtgg tgtctgatta tctttgttgc ctatatggta gcaggattta ttttctactt
    10081 tatcaagcaa atcaagagaa agtcatccta atactcttcg aaaatctctt caaaccacgt
    10141 cagtttccat ctgcaacctc aaaacactgt tttgaacaac ctgcggctag cttcctagtt
    10201 tgctctttga ttttcattga gtataagata caagggattc attttcgaat ttaagaagga
    10261 gtctacaaac caatgaggct tcttcttttc ttgcttattt gataactatc aaaaaagtag
    10321 aagattaaga gaaatataga aagagatttc atgaaacaat ttttagaacg ggccagcatt
    10381 ttggctctct ccctcgtttt gattacctcc ttttccattt cgagtgccct accagccatg
    10441 tttgactatt atcagggtta ttctaaggaa caaattgagc tcttggtgag cttgccttcc
    10501 tttggaatca tgatgatgtt actgctaaat ggtttcttag aaaaaatatt tcctgagcgc
    10561 ttacagatta gtttgggctt gctgatttta tcattgagcg gtacagctcc cttctggtac
    10621 caagcctatc cctttgtctt tggaacacgg cttctctttg gtttgggtct tgggatgatc
    10681 aatgccaagg ctatttctat tatcagtgaa cgctaccaag gaaaaaggcg aattcagatg
    10741 ttagggctac gcgcttctac agaggtcgtt ggagcttctc tcattacctt ggccgtcggt
    10801 cagttgttgg cctttggttg gacagctatc tttctagcct atagtgctgg atttttggtg
    10861 ctgccccttt atctgctctt tgtcccttat ggaaaatcaa agaaagaagt caagaaaaga
    10921 gcgaaggaag caagtcgttt aactcgagaa atgaaaggct tgatttttac cttagctatc
    10981 gaagcggcag ttgtagtttg taccaataca gctattacca tccgtattcc aagtttgatg
    11041 gtggaaagag gattggggga tgcccagtta tctagttttg ttcttagtat catgcagttg
    11101 atcgggattg tggctggggt gagtttttct ttcttgattt ctatctttaa agagaaactg
    11161 ctcctctggt ctggtattac ctttggcttg gggcaaatcg tgattgcctt gtcttcatct
    11221 ttgtgggtgg tagtagcagg aagtgttctg gctggatttg cctatagtgt agtcttgacg
    11281 acggtctttc aacttgtctc tgaacgaatt ccagctaaac tcctcaatca agcaacttca
    11341 tttgctgtat taggctgtag tttcggagcc tttacgaccc cattcgttct aggtgcaatt
    11401 ggcttactaa ctcacaatgg gatgttggtc tttagtatct taggaggttg gttgattgta
    11461 atctctatct ttgtcatgta cctacttcag aagagagctt aggattgatt cctaagtttt
    11521 tcttttgata ctcaatgaaa atcaaagagc aaactatagt tgattgagtt tggaatagta
    11581 cgctgtagct gctaaaatat ttctagaaat taatttgact ttcctaatag agttgttcat
    11641 atcttatttc aatctactat agaaagctag ccgcaggttg ctcaaaatag tgttttgagg
    11701 ttgcagatgg aaactgacgt ggtttgaaga gattttcaag agtataagat ttttataccc
    11761 atacaatatt tgttttaggt ccttgtttac agactaattt cttgataaaa tagaggttat
    11821 gacgagatat aaagcaacta tttcctatga tggttatgcc tttgctggct ttcagcgcca
    11881 gcctcatgcg cgtagcgttc aggaagaaat tgaaaaaacc ttgaccagat taaataaagg
    11941 gcaagccatt actgttcacg gtgctggtag gacagatagt ggggttcatg ccctgggaca
    12001 ggtcattcat tttgacctgc cttatcagat ggatgaggag aaactccgtt ttgccttgga
    12061 tacccagtct cctgaagata ttgatgtgat ttcgattgag cttgtggcag atgattttca
    12121 ttgccgttat gccaagcata gcaagaccta tgagtttact gtggatagag gacgtcccaa
    12181 aaatccgatg cgccgtcact atgccaccca ctttccctac ccactcgatg tggaacgaat
    12241 gcagattgca atcaaaaagc tagagggaac ccatgatttt accggtttta cagcctctgg
    12301 gactagtgta gaggataagg ttcgcaccat cacagaagct agtttaatag tcgatgagac
    12361 aggacaattt ttgaccttta ccttttccgg aaatggtttc ttgtataaac agattcgcaa
    12421 tatggtgggg actcttctca aaatcggtaa caaccgcatg ccagtagagc agattgatct
    12481 catcttggag aagaaggaca ggcaacttgc aggtcccact gcagcaccaa atggtttgta
    12541 tttaaaggag attcgttatg aagaataatc gtattttagc actttctgga aatgatattt
    12601 ttagtggtgg tggactgtca gctgatttgg ctacctatac cttgaacggc ttgcatgggt
    12661 ttgtagcagt gacttgtttg acagccttga cagaaaaagg atttgaagtc tttccaactg
    12721 atgataccat ttttcaacat gaattagata gcttgcgtga tgtggaattt gggggaatta
    12781 agattggtct tctccctact gtcagtgtgg ctgagaaggc cttggatttt atcaaacaac
    12841 gcccaggaat acctgtggtg ttggatcctg tcttggtctg caaggaaacg catgatgtag
    12901 ctgtcagtga gctctgccaa gagttgattc gctttttccc ttatgtcagt gtgattacgc
    12961 ctaatctccc agaagcagaa ttattatccg gtcaggaaat taaaaccttg gaagacatga
    13021 aaactgcagc gcagaaattg catgatttag gagcgccagc agtcattatc aagggaggca
    13081 atcgtcttag tcaggacaag gctgtggatg tcttttatga tggacagacc tttactatcc
    13141 tagaaaatcc agttatccaa ggccaaaatg ctggtgcagg ttgtaccttt gcctctagca
    13201 ttgccagtca cttggttaaa ggtgataaac ttttgccagc cgtagaaagc tctaaggctt
    13261 tcgtttatcg tgctattgca caagcagatc agtatggagt aagaacaata tgaagcaaac
    13321 aaaaacaact aaaattgccc ttgtatccct attaaccgcc ctttctgtgg ttctaggtta
    13381 tttcttaaaa atcccaacac ctacaggaat tctaactctt ttagatgctg gtgtcttctt
    13441 tgcggccttt tactttggta gtcgtgaagg agcggtagtc ggaggactag caagtttctt
    13501 gcttgacctc ttatcaggct accctcagtg gatgttcttt agcttggtca accatggctt
    13561 gcagggattt ttcgcaggat ttaaaggaaa aagtcagtgg ttaggcctta ttttagcaac
    13621 tattgccatg gtagggggct acgccttggg ttctactttg atgaatggct gggcagcagc
    13681 cctcccagaa attctaccaa attttatgca aaatatggca gggatgattg taggatttat
    13741 tcttagtcaa agtatcaaga agattaagta atactcttcg aaaatctctt caaaccacgt
    13801 cggcttccat ctgcaacctc aaaacactgt tttgagcagc ctgcggctag ctttctagtt
    13861 tgcactttga ttttcattga gtataaaaag atcttgggaa aagactcaat ttcagtagaa
    13921 aaggaagtaa atcttcccac attaaaacgc atattaccaa ggttcttatg aactgcaccc
    13981 caaaagttag acagaaaaaa tctaactttt ggggtgtttt tattatgaaa ttgagttgtg
    14041 atgataaagt tcagatctat gaacttagaa aacaaggata tagcttagag aagctttcaa
    14101 ataaatttgg gataaacaat tctaatctta ggtacatgat taaattgatt gatcgttacg
    14161 gaatagagtt cgtcaaaaaa gg
//
LOCUS       DAVHSO010000056        14012 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.057, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000056 DAVHSO010000000
VERSION     DAVHSO010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14012)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14012)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14012
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.057"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(26..904)
                     /locus_tag="VVR18_001723"
     CDS             complement(26..904)
                     /locus_tag="VVR18_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033209.1"
                     /translation="MRIKEKTNNINGGIKNVSKHYGHSIILKDINFALNKGEIVGQVG
                     RNGVGKSTLMKILVQNNQPTSGNIISSDNVGYLIEEPKLFLSKTGLENLKYLSNLYGV
                     DYNQERFRSLIQELDLTQSINKKVKTYSLGTKQKLALLLTLVTELDILILDEPTNGLD
                     IESSQIVLAVLKNLALHENVGILISSHKLEDIEEICERVLFLESGLLTFQKVGKDSHN
                     FLFEIAFSSATDRDIFITKQEFGDIVQEEGLRITMSGNIQSSELFKFFNENSIKVVDF
                     KTKKETLKDIYLNRSK"
     gene            complement(1239..1967)
                     /locus_tag="VVR18_001724"
                     /pseudo
     CDS             complement(1239..1967)
                     /locus_tag="VVR18_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
     gene            complement(2213..2524)
                     /locus_tag="VVR18_001725"
     CDS             complement(2213..2524)
                     /locus_tag="VVR18_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033210.1"
                     /translation="MIEAQGFLVDKQTRCIHYHSKLDIIALQCYDCKKYYACYRCHDS
                     LENHPFEPYPLSLIQDKPILCGVCLKLLTYKQYKESLSCPFCFSRFNPGCQNHKERYF
                     K"
     gene            complement(2539..3825)
                     /locus_tag="VVR18_001726"
     CDS             complement(2539..3825)
                     /locus_tag="VVR18_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEU6033211.1"
                     /translation="MTKTLKRPEVLSPAGTLEKLKVAVQYGADAVFIGGQAYGLRSRA
                     GNFTFEQMEEGVQFAAKYGAKVYVAANMVMHEGNEAGAGEWFRKLRDIGIAAVIVSDP
                     ALIMIAATEAPGLEIHLSTQASATNYETLEFWKELGLTRVVLAREVSMEELAEIRKRT
                     DVEIEAFVHGAMCISYSGRCTLSNHMSMRDANRGGCSQSCRWKYDLYDMPFGKERKSL
                     KGEIPEEFSMSAVDMSMIDHIPDMIENGVDSLKIEGRMKSIHYVSTVTNCYKAAVDAY
                     LESPEKFEAIKQDLVDEMWKVAQRELATGFYYGIPSENEQLFGARRKIPEYKFVAEVV
                     SYDDAAQTATIRQRNVINEGDQVEFYGPGFRHFETYIEDLHDAKGNKIDRAPNPMELL
                     TIKVPQPVQSGDMVRALKEGLINFYKEDGTSVTVRA"
     gene            4449..4631
                     /locus_tag="VVR18_001727"
     CDS             4449..4631
                     /locus_tag="VVR18_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001262531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ApaLI family restriction endonuclease"
                     /protein_id="HEU6033212.1"
                     /translation="MANDNKSHYLIYRVLGISFEEGENIDLYQNKGRFLYKYAGSFLE
                     EAAVLSFNEKFGTENT"
     gene            4641..5006
                     /locus_tag="VVR18_001728"
     CDS             4641..5006
                     /locus_tag="VVR18_001728"
                     /inference="COORDINATES: protein motif:HMM:NF021048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ApaLI family restriction endonuclease"
                     /protein_id="HEU6033213.1"
                     /translation="MPNSESTKPKTFEIDCLVGEKHAYEIKWWDATTDGDHITKEHTR
                     IKVIHNKGYIPIRLMFYYPNRTQAIKIQQTLETLYNGIGGKYYYGDSAWEHLRAVTGI
                     DLLSILTDIANKKTGVKSK"
     gene            5003..6193
                     /locus_tag="VVR18_001729"
     CDS             5003..6193
                     /locus_tag="VVR18_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific DNA-methyltransferase"
                     /protein_id="HEU6033214.1"
                     /translation="MTVLKGDNLEILKTIESSSIDLIYMDPPFFTQKTQKLSNNKNIM
                     YSFEDTWTSIEDYKEFLSVRLEECKRVLKNSGSIFVHCDKIANHHIRLILDNIFGADM
                     FQSEIIWNYKRWSNSKKGLLNNHQNIYFYSKSKDFKFNTIFTEYSSTTNIDQILVERK
                     RDGNSKTIYKVDNNGNYILAKEKNGVPLSDVWNIPFLNPKAKERVGYPTQKPILLLEQ
                     IIKIATDKNDIVLDPFCGSGTTLVASKILNRNYMGIDLSEEAINITQQRLENVIKTSS
                     NLLNKGIEAYRTKTEEEENILKLLQAKIVQRNKGIDGFLPKHFQKKPIPIKIQKNNEC
                     LNESISLLQNAINSKKLDFGVVIKTHSDNLLFDFDTIPENIIVVDHFELTIEKWLSKS
                     QQLL"
     gene            complement(6708..7700)
                     /locus_tag="VVR18_001730"
     CDS             complement(6708..7700)
                     /locus_tag="VVR18_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033215.1"
                     /translation="MSYYDFVKDYMKVDECKNNEKYSSAGHTFCWKKENSTYAEGLYW
                     FYEGGSFIIDIHDFYIKEEVVQNSTYSMSDYVSIYSSYIVSANGEKFNPYQTITANSL
                     CTFDFDNIKDDFVFLLHENCCYLAVSIGFKKELIEKHLASININPESFYSTLLQPNQI
                     ILTKALERVAMEILNCKMDAPAADFFFKAKANEWISIVIDTYLNRKKYKIEIDDDKAL
                     EDVARFLDDHFATNVNQGTLEKISKMSGTKLKNLFKEKYCQSITEYTQRKRMNVAETL
                     LLNTELPIKEIAESVGYSSASKFSIYYKRYKGKLPSEVRNLACKHHNFKCDYCD"
     gene            7860..9614
                     /locus_tag="VVR18_001731"
     CDS             7860..9614
                     /locus_tag="VVR18_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033216.1"
                     /translation="MKIYKKLFAYVQDKKYLGVLAIIFSAISAALTVYGYYLIYKFLD
                     KLIINSNLSGAESIALKSVITLTSGAIFYFVSGMFSHILGFRLETNLRKRGIDGLEKA
                     SFRFFDLNPSGQIRKIIDDNAAQTHQVVAHMIPDSSQAIVTPILVLVLGFIVSIRVGI
                     TLLALTIIGGLILGAMMGEQEFMKIYQESLSKLSAETVEYVRGMQVVKIFKANVESFK
                     SFYKAIKDYSKYAYDYSLSCKRPYVLYQWLFFGLIAILIIPIVYFMTSLASAKVILLE
                     LIMILFLSGVLFVSFMRMMWYSMYISQGNYAVDTLEALYEDMQKDKLVHGNVNNFKNY
                     NIEFENVSFAYNDKAVIENLSFNLEEGKSYALVGSSGSGKSTVAKLISGFYNVNEGSI
                     KIGGIAISEYSDEALIKAISFVFQDSKLFKKSIYDNVALANKDATKDDVMRALKLAGC
                     DLILDKFPERENTIIGSKGVYLSGGEKQRIAIARAILKDSKIIIMDEASASIDPDNEF
                     ELQKAFKNLMKDKTVIMIAHRLSTIKDLDEIIVMDSGKIIERGSDKELMSKDTRYKSL
                     QEMFNSANEWRVSNERVL"
     gene            9598..11319
                     /locus_tag="VVR18_001732"
     CDS             9598..11319
                     /locus_tag="VVR18_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019214631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033217.1"
                     /translation="MKEFYKKRFALTDGGARNLSKATLASFFVYCINMLPAILLMIFA
                     QEVLENMGKSNGFYIVFSILTLIAMYILLSIEYDKLYNTTYQESADLRIRTAENLSKL
                     PLSYFSKHDISDISQTIMADIEGIEHAMSHSIPKVGGMVLFFPLISVMMLAGNVKMGL
                     AVIIPSILSFIFIPLSKKYQVKGQNRYYDVLRKNSESFQENIEMQMEIKAYNLSKDIK
                     DDLYKKMEDSERVHLKAEVTTILTLSISSIFSFISLAVVIFVGVNLIINKEINSLYLI
                     GYLLAAMKIKDSLDASKEGLMEIFYLSPKIERLKEIQNQDLQEGDDYSLKKFDIDLKD
                     VEFAYNKDAKVLNGVSFKAKQGEVTALVGASGCGKTTILKLISRLYDYDKGQILIDGK
                     DIKEISTESLFDKVSIVFQDVVLFNQSVMENIRIGKQDASDEEVKRAAKLANCTDFIE
                     KMDKGFDTVIGENGAELSGGERQRLSIARAFLKDAPILILDEITASLDVNNEKKIQES
                     LNNLVKDKTVVIISHRMKSIENADKIVVLQNGRVESEGKHEELLQKSKIYKNLIEKTK
                     MAEEFIY"
     gene            11330..11914
                     /locus_tag="VVR18_001733"
     CDS             11330..11914
                     /locus_tag="VVR18_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEU6033218.1"
                     /translation="MDNKKLKVKDLVSIGVFGVIYFAFMFGVGMMGLIPILFLIYPTV
                     LAIVAGTVVMLFMAKVQKPWALFIFGMISPLVMFAAGHTYVVVVLSLIVMIIAELIRK
                     IGNYNSFKYNMLSYAIFSTWICSSLMQMLLAKEKYMEWSLMTMGKDYVDVLEKLITYP
                     HMALIALGAFLGGILGAYIGKALLKKHFEKAGIV"
     gene            11914..12609
                     /locus_tag="VVR18_001734"
     CDS             11914..12609
                     /locus_tag="VVR18_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001141947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU6033219.1"
                     /translation="MPTFSSNAPFNPNPISKILVVFITGLTVMHSINIRFELAIVCLI
                     GILLYLNGYKKTLFKWIILCGILYSLPNFMVLSELNPIVKMFLSIPIVIRMFILPFMA
                     ASFMIKTSDVGAIISSMDKLKISKNVSIPIAVMFRFFPSFKEEKKNIKMAMRVRGINF
                     KNPVKYLEYVSVPLLIISSNISDDIAKAAETKAIENPIAKTRYIRVKIQLIDFVYVLA
                     VAGLIAGGLIWLK"
     gene            12597..13961
                     /locus_tag="VVR18_001735"
     CDS             12597..13961
                     /locus_tag="VVR18_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002837029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033220.1"
                     /translation="MVEIKNLSLDYGEEHILDDISLSIAEGECVLFTGKSGNGKSSLI
                     NSINGLAVRYDNAKTKGKIIIDGKNIKNLELYQISMLVSTVFQNPKTYFFNVNTTLEL
                     LFYLENIGLAREEMDRRLKDMLEIFPIKNLLNRNIFNLSGGEKQILCIAASYIAGTKI
                     IVMDEPSSNLDIKSISVLAKMLKILKEKGISIIVAEHRIYYLMDIVDRVFLIDKGKLK
                     KTYTRREFLKLDKNELNALSLRDKELSKLKVPYLKEGGEYQIKNLSYKFTDDECLSLK
                     DISFKLGKIYGIIGSNGRGKSTLLRCLIGLEKKSKEEIYFKGEKLSKKERLKNSSLVM
                     QDVNHQLFTDEVFNELRLGVKNFDEEKAKIILKDLCLDEFIERHPMSLSGGQKQRLAI
                     ASVMCKNSPFVFFDEPSSGMDYSNMIKISELINKYKTMDKIIFIVSHDIEFLNEVADE
                     IFEL"
BASE COUNT         4947 a         2169 c         2322 g         4574 t
ORIGIN      
        1 ttaatttcat gattataacc ctcctttatt ttgaacgatt tagataaata tctttaagcg
       61 tctctttttt agttttaaaa tcaactactt taatagagtt ttcgttaaaa aatttaaaaa
      121 gctcactact ttgaatattc ccagacatag taattctcag tccctcttcc tgaacaatat
      181 ccccaaattc ttgtttggta atgaaaatgt ctctatctgt agctgatgaa aaagctatct
      241 caaacaagaa attatgacta tcttttccta ctttttgaaa tgtcaaaagc ccgctctcca
      301 agaaaagaac cctctcacaa atttcttcaa tatcttctaa tttatgactc gatattaaaa
      361 ttcccacatt ttcatgtaaa gctaaatttt ttagaaccgc taaaactatt tgtgatgatt
      421 caatatctaa accattagtc ggttcatcta aaatcaatat atcaagttct gtaacgaggg
      481 ttaaaagcaa agctaatttt tgttttgtac ccaaagaata ggtctttact tttttattaa
      541 tagactgagt caaatctaac tcttggatca aacttctaaa tctttcttga ttgtagtcaa
      601 caccatataa atttgacaaa tattttaaat tctctaaacc tgttttagat aaaaataatt
      661 ttggttcttc gattaaatac ccaacattat cactgcttat aatattacct gaagtcggtt
      721 gattattctg aacaagaatt ttcatcaacg tactcttacc aactccattt ctccctactt
      781 gaccaacaat ttcacccttg ttaagtgcaa aatttatatc tttgagaata attgaatgac
      841 cataatgctt acttacattt tttattcctc cattaatatt attggttttc tctttgattc
      901 tcattaattt taaaaagttg cgcctctttt taacaatatt atatcatata tctaacttaa
      961 tgcaatatat aaatgtcatt ttgtgaaatt ttattaacaa aaaactctat acaacaaaat
     1021 aatagagagt tttctgctta ttaatttttt tcaaaatatc taagacatcg cttctttgtt
     1081 taatttgata ggctttgata cctaagctcc gactttatca cttaaaaaat aaaaaagaca
     1141 gctaatctct tgcgcatcag gggatttcgc cattctttaa tctcgtttaa gtgttgtata
     1201 tggagctttg cataattttt taaaactaaa caactacatt aagctcgaac tgtgacgctg
     1261 gttccatctt ccttataaag attgataagc ccctctttaa gagctcgaac catgtctcca
     1321 gcttgaacag gttgtgggac tttaatagtc aatagttcca ttggatttgg agcgcggtcg
     1381 attttatttc ctttggcatc atgcaaatct tcaatatagg tttcaaaatg acggaaacct
     1441 ggaccataaa actcaacttg gtccccttcg ttaatgacgt tccgttgacg aatggttgct
     1501 gtttgtgtcg catcatcata agaaaccact tcagcgacaa acttgtactc aggaatttta
     1561 cgacgagcac caaacaactg ctcattttca gatggtgtac catagtaaaa tcctgtaacc
     1621 agttcacgtt gggcaacctt ccacatctcg tccaccaagt cttgtttgat agcttcaaac
     1681 ttttcagaac tttcaagata ggcatccaca gccgccttgt agcagttggt tactgttgat
     1741 acgtagtgaa tagacttcat acgtccttcg atttttagac tgtccacacc attttcaatc
     1801 atatctggaa tgtggtcaat catagacatg tcaacggctg acattgaaaa ttcttctgga
     1861 atctcaccct gcaaactctt acgttctttc ccaaatggca tatcgtaaag gtcgtatttc
     1921 caacggcatg actgagaaca tccaccacgg ttggcatcac gcatactcta gacggattgt
     1981 tttgacaatt ctaacctttt agactttgca taataactgt taaacagtcg aaaattaccc
     2041 cagttttaac aagtagtcaa aataccagat aaaggaaaaa agtctttaaa atcttaaaaa
     2101 cgcatagtat caggtattga acaatcttga tattatgcgt tttattgtgg gaagatttac
     2161 ttcattttct cttggaattg agttttctcc tacttcaaaa ctagatgatt tgctatttaa
     2221 aatagcgttc cttatgattt tggcaacctg gattaaagcg agaaaaacaa aaggggcaac
     2281 ttaaactttc tttatattgc ttatatgtta gtagttttag acaaacacca cataaaatag
     2341 gcttatcctg tatcaaagat aagggatacg gctcaaaagg gtgattttct aatgaatcat
     2401 gacaccgata acaagcatag tactttttac aatcatagca ttgtaaagca ataatatcca
     2461 acttgctatg gtaatgaatg catcttgttt gcttatccac taagaaaccc tgtgcctcta
     2521 tcatttcctt ttcctttctt aagctcgaac tgtgacgctg gttccatctt ccttataaaa
     2581 attgatgagt ccttctttta atgcacgaac catgtctcct gattgaacgg gttgtgggac
     2641 tttaatagtc aatagttcca ttggatttgg agcgcggtcg attttattgc ctttggcatc
     2701 atgcaaatct tcaatatagg tttcaaaatg acggaaacct ggaccataaa actcaacttg
     2761 gtccccttcg ttaatgacgt ttcgttgacg aatagttgct gtttgtgccg catcatcata
     2821 agaaaccact tcagcgacaa acttgtactc aggaatttta cggcgagcac caaacaactg
     2881 ctcattttca gatggtatac cgtagtagaa acctgttgcc aattcacgtt gggcaacctt
     2941 ccacatctcg tccaccaagt cttgtttgat agcttcaaac ttttcaggac tttcaagata
     3001 ggcatccaca gccgccttgt agcagttggt tactgttgat acgtagtgaa tagacttcat
     3061 acgtccttcg atttttagac tgtccacacc attttcaatc atatctggaa tgtggtcaat
     3121 catagacata tcaacggctg acattgaaaa ttcttctgga atctcaccct tcaaactctt
     3181 acgttctttc ccaaatggca tatcgtaaag gtcgtatttc caacggcatg actgagaaca
     3241 tccaccacgg ttggcatcac gcatactcat gtggtttgaa agagtacaac gtccagagta
     3301 tgaaatacac atagctccat ggacaaaggc ttcaatttca acatctgtac gtttgcggat
     3361 ttcagctaat tcttccattg aaacctcacg cgctaaaacg acacgagtca agcctagctc
     3421 tttccagaac tcaagggttt catagttagt ggcactggct tgggtagaaa ggtggatttc
     3481 aaggcctggt gcttcagtcg ctgcaatcat aatcaaggct gggtcagata cgataactgc
     3541 tgcaatccca atatcacgca gtttacggaa ccactcacca gcaccagctt catttccttc
     3601 gtgcataacc atattagccg ctacatagac cttggcacca tacttggccg caaactgcac
     3661 gccttcttcc atctgttcga aagtaaagtt tccggcacgg ctacgaagac cataggcctg
     3721 accaccgata aagacagcat ctgctccata ctgaacagct acctttagct tctctaaagt
     3781 ccctgcaggt gataaaacct caggacgttt taatgttttt gtcatgattt ctcctatttg
     3841 caatataaaa gtttgacatt tttccttctc attttatagt aaataaagga taaaatcaag
     3901 cctagacgga ttgttttgac aattctaatc ttttagactt tgcataataa ctgttaaaca
     3961 gtcgaaaatt accccagttt taacaagtag tcaaaaagtc tagaaaagta aaaaccagta
     4021 tccaaagata ctgactcgta aaaatacata aattagtcct tagatgacta ctcccactct
     4081 gttgctccta taatggaaaa ggattgatac agtctagaat atcgcttttt tatttattat
     4141 tctgatataa aactgttaga attgattttt tgttttatac ccaaatatga atagagacgt
     4201 agctaataag ttgaataaca tatttggaaa aatgagaaat agcaatatta ctagaacttt
     4261 tagaaacaat caatatttaa aaagaaaaaa gctcaaagaa tttattaaac catgttataa
     4321 tagatatagc tataatttta tttataacaa gaggatagaa atgaccgaat tagaaagaaa
     4381 aaatcgaaaa attagctaag aaatattcta ataacttaaa catcaaagtt caagagagag
     4441 ttcgtgaaat ggcaaatgat aataagagcc attatttgat atacagagtt ttaggtattt
     4501 catttgaaga aggagaaaat atcgatttgt atcaaaataa aggtcgtttt ttatacaaat
     4561 atgctggttc atttttagaa gaagctgcag tactatcctt taacgaaaaa tttggtacag
     4621 aaaatactta aaaagttaac attcctaatt ctgaaagtac aaaacctaag acttttgaaa
     4681 ttgattgttt agtcggagaa aaacacgcat acgaaataaa atggtgggat gcaactacag
     4741 atggagacca tataactaaa gaacacacta gaataaaagt tattcataac aaaggatata
     4801 taccaattcg gttaatgttc tactatccaa atagaactca agctataaaa attcagcaaa
     4861 ctttagaaac attgtataac ggtattggag ggaaatatta ttatggagat tctgcctggg
     4921 aacatttaag agcagtgacc ggtattgatt tacttagtat tctaacagat attgcaaata
     4981 aaaaaacagg ggtaaaatca aaatgacagt attaaaagga gataacttag aaatattaaa
     5041 aactattgaa tcctcaagta ttgatttaat ctatatggac cctcctttct ttacacagaa
     5101 aacccaaaaa ttatctaata acaaaaatat tatgtattca ttcgaagata cgtggacttc
     5161 gattgaggat tacaaagaat ttttgtctgt aagattagaa gaatgcaaaa gagtgctaaa
     5221 aaatagtggc agtattttcg ttcattgtga taaaattgca aatcatcata ttagattaat
     5281 tttagataat atctttggag cagatatgtt tcaaagcgaa attatatgga actataaacg
     5341 gtggtctaat tcaaaaaagg gattattgaa caatcatcaa aacatttact tttattcaaa
     5401 gtcaaaagat tttaaattta atacaatttt tacagagtat tcttctacta caaatatcga
     5461 ccaaatacta gtggaacgaa aacgagatgg aaactctaaa actatatata aagttgataa
     5521 taatggtaac tatattctag caaaagagaa aaatggagtt cccctttcag atgtttggaa
     5581 tataccattt cttaatccaa aagctaaaga aagagtaggt tatcctacac aaaaacctat
     5641 tctgttatta gaacaaatta taaagattgc tactgataaa aatgatatag ttttagaccc
     5701 gttctgtgga agtggaacta ctttagtagc ctccaagatt ttgaatagaa attatatggg
     5761 gattgattta tctgaggaag ctatcaatat aactcagcaa cgtctggaaa atgttataaa
     5821 aacaagttca aatttattga ataaaggaat cgaagcatat agaaccaaaa ctgaggaaga
     5881 ggaaaacatt cttaaattat tacaggcaaa aattgttcaa agaaataaag gaattgatgg
     5941 ttttttacct aaacattttc aaaaaaaacc gatacctata aaaattcaaa aaaataatga
     6001 atgtctgaat gagagtatct ctttattaca gaatgctata aactccaaaa aacttgattt
     6061 tggagtagtt ataaaaactc attcagataa tttattattt gattttgata cgattcctga
     6121 aaatataata gtagttgacc attttgaact tacaatcgaa aaatggttaa gtaaaagtca
     6181 acagttacta tagtttgcaa attatttaca gaaagaacaa aaaatgctct gaaacactga
     6241 tttcaaagca ttttttgtta gtttaaaatt actcccattc ttcttttcca aacgtacaat
     6301 atatccaaaa ccattcaaaa tactagattc tattttttat aatattacta aatccaccta
     6361 attataggac gttttcagat ttttagtccc gtcccagtcc cagtaccgga gaaatattgt
     6421 tttaatataa tatctctttt tgtcttctaa gctcttaaaa gcaaaagaac aagtaaagag
     6481 tcaagacaag gataaaaagt ccatattagg gcaaataaaa agctttaaga cagatgacaa
     6541 atttaagtca aataagaaag accatagcaa aggtgcagag agataaatat tggcggtctt
     6601 cggactgcct ttattttttt atccattttt caaatcaaat ttattcagac tatacatgca
     6661 catatacact taaattaata taaaaacatg gcttgtaaaa aattacttta atcacaataa
     6721 tcgcatttaa aattgtgatg tttgcaagct aaattacgga cttcacttgg aagttttccc
     6781 ttgtatcttt tataatagat agaaaatttg ctggcagatg aatatccaac agattctgct
     6841 atctctttta taggtagttc agtgtttaaa agaagagttt cagctacatt cattcttttt
     6901 ctttgagtgt actctgtaat gctttgacaa tatttttcct taaataaatt ttttaattta
     6961 gtaccactca ttttagatat tttttcaagc gtgccttgat ttacattcgt tgcaaaatga
     7021 tcatctaaga atcttgctac atcttcaagt gctttatcat catcaatttc aattttatat
     7081 ttttttctat ttaagtatgt gtcaattact atacttatcc attcatttgc ctttgcttta
     7141 aagaaaaaat cagcggcagg agcgtccatc ttacaattta atatttccat tgccactctt
     7201 tctaaggcct ttgtaagtat tatttgattc ggttgaagca aggttgaata aaaagattct
     7261 ggattaatgt taatagatgc taaatgtttt tctattagct cttttttaaa accaatggaa
     7321 acagcaagat aacaacaatt ctcgtgtaat aaaaaaacaa aatcatcttt tatattatca
     7381 aaatcaaaag tacataaaga gtttgcggta atagtttgat acggattaaa cttttctccg
     7441 tttgcactga caatgtaact tgaataaatt gaaacatagt ctgacatact ataagtgcta
     7501 ttttgaacta cttcctcttt gatataaaaa tcatgtatat cgataatgaa gctgcctcct
     7561 tcataaaacc aatataggcc ttctgcataa gttgaattct cttttttcca acaaaatgta
     7621 tgacctgcac ttgaatactt ctcattgttt ttacattcat ctactttcat ataatctttt
     7681 acaaaatcat aatatgacat aacacactat cccttttaga caatattcca attagcctta
     7741 ttaattcaaa actattgtat tagtaattat aacagatgta taatagaaaa gcaatgatag
     7801 atattatcaa ttaagcgaat ttatatctaa aagggatatt aaagaaagga gatatgctta
     7861 tgaagattta caaaaaacta tttgcttatg tccaagataa gaaatatctt ggggttttgg
     7921 ccataatttt ttctgctata tctgctgcac ttacagtata tggatattat ttaatctaca
     7981 aatttctaga taagttaata attaattcaa acttatccgg tgcagagagt atagcattaa
     8041 aatctgttat tacactaaca agtggagcga tattttattt tgtctcagga atgttttcac
     8101 atatcttggg atttaggctt gaaacaaatt taagaaaaag gggaatcgat ggtctggaaa
     8161 aagcaagttt taggttcttt gacttaaatc catctggtca aataagaaag atcatagatg
     8221 ataatgcagc acaaactcat caggtggtag ctcacatgat tccagatagc tctcaggcaa
     8281 tagtcacacc tatacttgtc cttgtactag gctttatagt aagtataagg gttggtataa
     8341 ctttgcttgc tcttactata attggcggct taattttagg ggcaatgatg ggcgagcaag
     8401 aatttatgaa gatataccaa gaatccctat ctaaactaag tgctgaaact gttgagtacg
     8461 tgagaggaat gcaagttgta aaaatattta aagcaaatgt agagtcattt aaaagctttt
     8521 acaaggctat aaaagattac tcaaagtatg cttatgatta ttccctatct tgtaaaaggc
     8581 cttatgtttt gtatcaatgg ttattttttg gactgattgc aattttaatt attcctatag
     8641 tttattttat gactagctta gctagcgcaa aggtgatttt acttgagctt atcatgattt
     8701 tatttttatc aggagttctc tttgtttcat tcatgagaat gatgtggtac tccatgtata
     8761 tttctcaagg aaattatgca gtagatactt tagaggcgct ttacgaagat atgcaaaaag
     8821 acaaattagt gcatggtaat gtcaataatt ttaaaaacta taatatagaa tttgagaatg
     8881 ttagctttgc ttataatgat aaagctgtca ttgaaaattt atcctttaat ttagaagaag
     8941 gaaagtccta cgcacttgtc ggttcatctg gatcaggcaa atcaacagta gcaaaactta
     9001 tatcaggttt ttacaatgtt aatgaaggaa gcataaagat aggcgggata gcaataagtg
     9061 aatattctga cgaagcctta attaaagcca tttcctttgt ttttcaagat tcaaaattat
     9121 tcaagaagag catttatgat aatgtagctt tagctaataa agatgcgacg aaagatgacg
     9181 ttatgagagc cttaaaatta gcaggatgcg atttaatatt agacaaattc ccagaaagag
     9241 aaaatacaat cataggctca aaaggtgttt atttatccgg tggagaaaaa caaagaattg
     9301 caattgctag agcaatttta aaggattcca aaattattat tatggatgaa gcatcagcat
     9361 ctattgaccc agataatgag tttgaattgc aaaaagcttt taaaaatctt atgaaggata
     9421 aaacagttat catgattgca cacaggctat ctacaattaa agaccttgat gaaattattg
     9481 tcatggatag tggaaaaatt atagaaagag ggtctgacaa agaattaatg tcaaaagata
     9541 caaggtataa gagcctgcaa gagatgttta acagtgcgaa tgaatggagg gtttcaaatg
     9601 aaagagtttt ataaaaaaag atttgctctt acagatggag gagcaagaaa tttaagtaaa
     9661 gcaacactgg cttcattttt cgtttattgt ataaacatgc ttcctgccat attacttatg
     9721 atttttgctc aggaagtttt ggaaaatatg ggcaaaagca atggctttta tatagtattc
     9781 tcaattttga ctttgatagc aatgtatatt ttgctttcta tcgaatacga taaattatat
     9841 aacacaacct atcaagaaag tgcagattta agaataagga cagcggagaa tttatcaaaa
     9901 ttacctctat cttacttttc taaacatgac atttccgaca tttcacaaac aatcatggct
     9961 gatattgaag gcatagagca tgcaatgagc cactcaatac caaaggtggg cggcatggta
    10021 ctgtttttcc cattaatatc tgtaatgatg ctagcgggca atgtcaagat gggtttagct
    10081 gtaattattc catctatttt aagctttata tttatacctt tatctaaaaa atatcaggtt
    10141 aagggacaga atagatatta tgatgtctta agaaaaaact cagaaagctt tcaagaaaat
    10201 atcgaaatgc aaatggagat taaagcatat aatttatcga aggatattaa agatgactta
    10261 tataaaaaaa tggaagatag tgagagagta cacttaaagg cggaagtaac tacaatttta
    10321 actttgtcta tatcttcaat atttagcttt atatctcttg ctgttgtgat atttgtcggc
    10381 gtaaatctaa ttattaataa agagataaat tctctctacc ttataggata tttactagct
    10441 gctatgaaga taaaagactc tttagatgca tctaaagagg gcttgatgga aatattttat
    10501 ttatcgccca aaatagaaag attaaaagaa attcaaaatc aagatctaca agaaggcgat
    10561 gactatagct taaaaaaatt tgatattgat ctaaaagatg ttgagtttgc ctacaataaa
    10621 gacgcaaaag ttttaaatgg tgtaagtttt aaagctaagc agggagaggt cactgctttg
    10681 gtaggtgcaa gtggctgcgg taaaacaact atcttgaaac ttatatcaag actttatgat
    10741 tatgacaagg gacaaatctt aatcgatggc aaagatataa aagaaatatc aacagaatct
    10801 ctttttgata aggtctctat agttttccaa gatgtggttc tctttaatca aagcgttatg
    10861 gaaaatatta gaatcggaaa gcaagatgca agtgacgaag aggttaaaag agcagcaaaa
    10921 cttgcaaatt gcacagattt tatagaaaaa atggataaag gtttcgatac agttattggt
    10981 gagaacggag ctgagctatc aggaggagaa agacaaagat tatcaatagc cagagccttc
    11041 ttaaaagatg cgccgatatt gatcttagat gagataacag caagccttga tgttaacaac
    11101 gagaaaaaga ttcaagagtc tttaaataat ttagttaaag ataaaactgt tgtaatcatt
    11161 tcacatagaa tgaaatccat agaaaatgca gacaagatag tagttcttca aaacggaaga
    11221 gtagaaagcg aaggtaagca tgaagagctt ttacaaaaat caaaaattta caaaaattta
    11281 atagaaaaga caaaaatggc agaagaattt atttattagg aggactacaa tggataataa
    11341 aaaattaaaa gtaaaagatt tagtaagtat cggtgttttt ggcgtaattt attttgcctt
    11401 catgtttgga gttggtatga tgggcttgat tccaatattg ttcttaatat acccgacagt
    11461 attagccata gttgcaggaa ctgttgttat gttatttatg gctaaggttc aaaagccatg
    11521 ggcactattt atatttggta tgatatcacc acttgtgatg tttgcagctg gtcataccta
    11581 cgtagttgtg gttttatcac ttatagtaat gataatagca gaattaatta gaaagattgg
    11641 taattataat tcatttaaat acaatatgct ttcttatgca atcttcagca catggatatg
    11701 tagctcttta atgcaaatgc ttttagcaaa agaaaaatat atggagtggt ctttgatgac
    11761 gatgggaaaa gattatgttg atgtattaga aaagttaata acttatcctc acatggcttt
    11821 aatagcctta ggtgctttct taggaggaat tcttggagca tatataggca aggctctatt
    11881 gaaaaaacac tttgaaaaag caggcatcgt ataatgccta ctttttcttc aaatgctccc
    11941 tttaatccca atccgatctc taagatatta gtcgtattta tcacaggctt aactgttatg
    12001 catagcataa acatccgttt tgagctggca attgtttgtc ttattggtat tttgctttat
    12061 ttgaatggat acaaaaaaac acttttcaaa tggattatat tgtgtgggat actttactcc
    12121 ttgcctaatt ttatggtatt atctgaatta aaccctatag ttaagatgtt tttgagtata
    12181 cctattgtta ttagaatgtt tattttacca tttatggcag caagctttat gataaagacc
    12241 tcggatgtag gcgcaataat ttcatcgatg gataagctta agatttcaaa gaatgtatcc
    12301 atacctattg cggttatgtt tagattcttc ccatctttta aggaggagaa gaaaaacatc
    12361 aaaatggcta tgagagtaag agggataaat tttaaaaacc cagtcaaata tcttgaatat
    12421 gtttctgtgc cactactcat tatatcatct aatatatcag atgacattgc aaaagcggca
    12481 gaaacaaagg caatagaaaa tccaattgcc aagaccagat acattcgcgt aaagatacag
    12541 ctaattgatt ttgtttatgt tttagcggtt gctggactta ttgcgggagg cttaatatgg
    12601 ttgaaataaa aaatttaagt cttgattatg gtgaagagca tatattagat gatatatcac
    12661 tatccatagc cgagggagag tgcgtgctat ttacaggaaa aagtggaaat ggtaagtcat
    12721 ctttaataaa ttcaatcaat ggactagctg taaggtatga taacgcaaag acaaagggca
    12781 aaataattat tgatggtaag aatataaaaa atttggaact ttatcaaatc tcaatgcttg
    12841 tttcaactgt ttttcaaaat cctaagacct atttttttaa tgtcaatacg acattagaat
    12901 tattatttta tttggaaaat atcggtcttg caagagaaga gatggacagg cgtttgaagg
    12961 atatgcttga gatattcccg ataaaaaatc ttttgaacag aaatatattt aatctatccg
    13021 gcggtgaaaa acaaattctt tgcattgcag cttcttatat agcaggtaca aagattatag
    13081 ttatggatga gccttcatcg aatttagata ttaaaagcat aagtgttttg gcaaagatgc
    13141 taaagatatt aaaagagaaa ggcataagca taattgttgc agagcataga atttattatt
    13201 tgatggacat agttgaccgt gtatttttaa tagataaagg aaagcttaaa aaaacttata
    13261 ctagaaggga atttttaaag ctagataaaa atgaattaaa tgctttaagt ttaagagata
    13321 aagaattaag taaattaaaa gttccttatt taaaagaagg tggagagtat cagataaaaa
    13381 atcttagcta caaatttact gatgatgagt gtttaagctt aaaagatatt tcgttcaagc
    13441 ttgggaaaat ttatggcata ataggatcca acggacgagg aaaatcaacg cttttaagat
    13501 gtttaatagg tcttgagaaa aaatcaaaag aagaaattta ttttaaggga gagaagctat
    13561 ctaaaaaaga aagactcaaa aactcttcac ttgttatgca agatgtaaat catcaattat
    13621 tcacagatga agtattcaac gagcttagat taggagtaaa gaattttgat gaagaaaagg
    13681 cgaaaatcat tttaaaagat ttatgcctgg acgaatttat tgaaaggcat ccgatgagtt
    13741 tatcaggagg gcaaaagcaa aggcttgcaa tagcatctgt tatgtgcaag aattctccat
    13801 ttgtcttttt tgacgaacct tcaagtggta tggattattc caatatgata aaaatatctg
    13861 aactgattaa taagtataaa accatggata aaataatttt tattgtttcc catgatatag
    13921 aatttttaaa tgaagtggca gatgaaattt ttgaattgta aaatagagtc tgttaaacat
    13981 gtctatagaa ctagtaaatt gtctaaaaat tt
//
LOCUS       DAVHSO010000057        13971 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.058, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000057 DAVHSO010000000
VERSION     DAVHSO010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13971)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13971)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13971
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.058"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            105..302
                     /locus_tag="VVR18_001736"
     CDS             105..302
                     /locus_tag="VVR18_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEU6033221.1"
                     /translation="MAGKITKKSSSMGIIANVFAGLVGAYAGQSLLGSWGPSIAGMAL
                     LPSIVGAAIVITVVSFFTGRK"
     gene            386..952
                     /gene="amaP"
                     /locus_tag="VVR18_001737"
     CDS             386..952
                     /gene="amaP"
                     /locus_tag="VVR18_001737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="HEU6033222.1"
                     /translation="MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNS
                     VVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFV
                     RSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFG
                     IERQVKLEVAVKNYQPKPQNKKTVSRVK"
     gene            964..1134
                     /locus_tag="VVR18_001738"
     CDS             964..1134
                     /locus_tag="VVR18_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2273 domain-containing protein"
                     /protein_id="HEU6033223.1"
                     /translation="MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVA
                     AGLYIEKNYIDK"
     gene            1173..1781
                     /locus_tag="VVR18_001739"
     CDS             1173..1781
                     /locus_tag="VVR18_001739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEU6033224.1"
                     /translation="MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLEN
                     VSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSE
                     IREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQ
                     FEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN"
     gene            1812..2015
                     /locus_tag="VVR18_001740"
     CDS             1812..2015
                     /locus_tag="VVR18_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEU6033225.1"
                     /translation="MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVA
                     EDAKDAVEGAVEGVKNMLHKEEK"
     gene            complement(2088..2534)
                     /locus_tag="VVR18_001741"
     CDS             complement(2088..2534)
                     /locus_tag="VVR18_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033226.1"
                     /translation="MTIRFEEKVSIENAQLVCQWSNSLGKVFQEQWMGPRIPFLLTLQ
                     ALEGVFSIFDEQEFVGLIQKIRLEDSNLHIGRFFINPQKQEQDLGSQALRKFVSLAFE
                     NEDIDSISLNVFEANQRAQNLYQKEGFEIVQMVEAPVRKYIMKKGR"
     gene            2604..3263
                     /locus_tag="VVR18_001742"
     CDS             2604..3263
                     /locus_tag="VVR18_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HEU6033227.1"
                     /translation="MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLR
                     PLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLGLLFLLYSWELLSLGQVVLITAG
                     LTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
                     FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLL
                     V"
     gene            complement(3315..4466)
                     /locus_tag="VVR18_001743"
     CDS             complement(3315..4466)
                     /locus_tag="VVR18_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HEU6033228.1"
                     /translation="MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKL
                     STKMHLANQFHVDLTYFEQEEESVRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLI
                     DYFESFVIIPNITIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERS
                     GIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMN
                     EDGDRLEQEANYFASCFLLPKEEFLVKFEERVGKRVSNPDSYILLKSDLNVSIQALEY
                     RAFKLGLLSLKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSL
                     ATIMSKQSIRLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL"
     gene            complement(4481..5210)
                     /locus_tag="VVR18_001744"
                     /pseudo
     CDS             complement(4481..5210)
                     /locus_tag="VVR18_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000934015.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            5439..5540
                     /locus_tag="VVR18_001745"
                     /pseudo
     CDS             5439..5540
                     /locus_tag="VVR18_001745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234126.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
     gene            complement(5512..6288)
                     /locus_tag="VVR18_001746"
     CDS             complement(5512..6288)
                     /locus_tag="VVR18_001746"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="HEU6033229.1"
                     /translation="MPKTLTKKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLE
                     DLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTY
                     FNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGI
                     ERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQV
                     DLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK"
     gene            complement(6281..7504)
                     /gene="trpB"
                     /locus_tag="VVR18_001747"
     CDS             complement(6281..7504)
                     /gene="trpB"
                     /locus_tag="VVR18_001747"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HEU6033230.1"
                     /translation="MAYQEPNKDGFYGKFGGRFVPETLMTAVLELEKAYRESQADPSF
                     QEELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLA
                     KRMGKKKIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQALNVFRMELLGAKV
                     EAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQ
                     QYRDLTGQNLPDALVACVGGGSNAIGLFHPFVEDESVAMYGAEAAGFGVDTEYHAATL
                     TKGRPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTD
                     EEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKELGPEKSMIVCLSGRGDKDVVQVK
                     DRLEADAAKKGEAHA"
     gene            complement(7482..8081)
                     /locus_tag="VVR18_001748"
     CDS             complement(7482..8081)
                     /locus_tag="VVR18_001748"
                     /EC_number="5.3.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="HEU6033231.1"
                     /translation="MTKVKICGLSTKEAVETAVSAGADYIGFVFAPSKRQVTLEEAAE
                     LAKLIPADVKKVGVFVSPSRVELLEAIDKVGLDLVQVHGQVADDLFENLPCASIQAVQ
                     VDGNGHVPNSQADYLLFDAPVAGSGQPFDWGQLDTTGLAQPFFIAGGLNEDNVVKAIQ
                     HFTPYAVDVSSGVETDGQKDHEKIRRFIERVKHGISGTK"
     gene            complement(8068..8835)
                     /gene="trpC"
                     /locus_tag="VVR18_001749"
     CDS             complement(8068..8835)
                     /gene="trpC"
                     /locus_tag="VVR18_001749"
                     /EC_number="4.1.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011227478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="HEU6033232.1"
                     /translation="MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDR
                     LQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGTVMISVLTDEVFFKGHLNYLREIS
                     SQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKKLYDYATELGLEVLV
                     ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTG
                     QDAERLAPYFNGILVGTALMQAENVAQRIKELQIDKG"
     gene            complement(8832..9836)
                     /gene="trpD"
                     /locus_tag="VVR18_001750"
     CDS             complement(8832..9836)
                     /gene="trpD"
                     /locus_tag="VVR18_001750"
                     /EC_number="2.4.2.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="HEU6033233.1"
                     /translation="MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALK
                     MKGETPEERTAIAQVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGG
                     IHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKY
                     IMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVA
                     GPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEGYAMEDIRGGNAQENAEILLS
                     VLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKALEKLRLLQEYQK
                     "
     gene            complement(9847..10413)
                     /locus_tag="VVR18_001751"
     CDS             complement(9847..10413)
                     /locus_tag="VVR18_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HEU6033234.1"
                     /translation="MILLIDNYDSFTYNLAQYIGNFAEVQVLRNDDSKLYEEAEKADG
                     LVFSPGPGWPVDAGKMEDMIRDFAGKKPILGICLGHQAIAEVFGGKLGLAPKVMHGKQ
                     SNINFEAPSVLYQGIEDGRAVMRYHSILIEEMPEDFEVTARSTDDQAIMGIQHKNLPI
                     YGFQYHPESIGTPDGLSSIRNFIEEVVK"
     gene            complement(10410..11771)
                     /gene="trpE"
                     /locus_tag="VVR18_001752"
     CDS             complement(10410..11771)
                     /gene="trpE"
                     /locus_tag="VVR18_001752"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate synthase component I"
                     /protein_id="HEU6033235.1"
                     /translation="MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFSILAY
                     NPVFEIKFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAIGFVGYDMISL
                     YEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQEALEKSLNQV
                     LEELRIPAPNEFEDLDLSPLDFKPHIAPHKFEVMVETARDLIRNGDMFQCVLSQRFSA
                     EVTGNPFDFYRNLRVTNPSNYLYFYDFGDYQIIGASPESLVSVKNGIVTTNPIAGTRP
                     RGATDEEDKTLATDLLSDEKETAEHRMLVDLGRNDIGRISETASVQVTKYMKVELFRY
                     VMHLTSVVKGRLLAELTAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAI
                     GYLSATGDMDLAIAIRTMILKNQRAYVQAGAGIVYDSIAQNEYQETINKAKSMTRIGE
                     LRP"
     gene            complement(11906..12061)
                     /locus_tag="VVR18_001753"
     CDS             complement(11906..12061)
                     /locus_tag="VVR18_001753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033236.1"
                     /translation="MEKLQFFLSQRACGCWKQAEKAVKLGSSETREENIILKGVPFIA
                     QPVTGDI"
     gene            complement(12273..12350)
                     /locus_tag="VVR18_001754"
                     /pseudo
     CDS             complement(12273..12350)
                     /locus_tag="VVR18_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(12958..13959)
                     /locus_tag="VVR18_001755"
     CDS             complement(12958..13959)
                     /locus_tag="VVR18_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000789954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU6033237.1"
                     /translation="MKNINGKKVTIYDIARLSGFSPKTVSRVINGGVNVKEETYQAIQ
                     KVIEELSYIPNAYAKNLTKKEAINILISVKKIDSFPLIWFHTLLDKVLRTCKEFGVNA
                     IVEYFGEEDTISNSIISSTGSLVDGVIVFYESVDDIRIQYLKKNHMPFLVFGESQTSG
                     VVYVSNNNFQATYDMMKAVTEEKFKNMWLLMGGESHVNKDRERGVRSFLNDKNYFMDL
                     KVIYGLSTIDSVYSYAMQHLTTQNYPDIIFVSGDEKVQGLIRACYEKGILIPDDISII
                     GFDNIPISQYYTPALSTIAPNYVKLAKEMIEGVLAIIKGESVTSVEVSPKFVRRQSF"
BASE COUNT         4053 a         3027 c         2507 g         4384 t
ORIGIN      
        1 ttatataata gtattaatca aagaaattga ttttttgata ttaaaataaa aaaggagggt
       61 aggcagtgtt gtgatcaatt attgctggag gtcttattgg tctcttggca ggtaaaatca
      121 ctaaaaaaag tagttctatg ggaatcatcg caaatgtatt cgctggttta gtcggggcat
      181 atgcaggaca atctctttta ggtagttggg gtccatcaat cgctggaatg gctttgctcc
      241 catctattgt aggtgcagcg attgtgatta ctgtagtgtc attctttaca ggtagaaagt
      301 aaacttttcg ccagtaaagt tagcaaacta tttttaaatc aatgacggga aaaatagttt
      361 aaatgttaaa tcgaaaggat tgtatatgtc aaaagcaaag aaaatatgtt tcattatttt
      421 ctgtatttta atcttgacaa ttttccttcc tgttttgata gattatcatc aagttagtga
      481 tctaggtatt catctactta gctggagaca gaactccgta gttgaattct atcttgctag
      541 atatgtcttt tgggggacag tggttctatc aactttagtt ttattatcca ttttagttgt
      601 gatgttttat cctaaacgtt acttggaaat ccaacttgaa actaaaaacg atacattaaa
      661 attaaagaat tcggcaatcg aaggttttgt tagaagtttg gtgagtgatc atagattgat
      721 caagaaccca actgttcatg taaatttacg aaaaaataaa tgtttcgttc atgtagaagg
      781 taaaattctt ccttcagaca acatcgctga cagatgccaa ataattcaaa atgaaataac
      841 taatggattg aagcagtttt ttggtattga gcgtcaagta aaacttgaag ttgcagtaaa
      901 aaattaccaa ccaaaacctc aaaacaaaaa gactgttagt cgtgtgaagt aaggaagtaa
      961 aaaatggaat ggcttaaaca atatcgatat ccaattatcg ctggtctcat aggcgtattt
     1021 ctggcttgtt tgattgtctc ctttggcttc ttcaaaacaa tatttgtatt gattttagga
     1081 gcactgggag ttgcagctgg attatatatc gaaaaaaact atatagataa ataaaaaaat
     1141 aaaaattact aatttaatta aaggagtttc atatgtcaaa cgaaaaaaac acaaacacta
     1201 acgtagaaaa gaaagatgct actgttgtag ctcacgaaat caaaggggaa cttacttacg
     1261 aagataaagt tatccaaaaa atcattggtc tttcactaga aaacgtttca ggtcttttgg
     1321 gaatcgatgg tggtttcttc tcaaatctta aagaaaaaat cgttaacagc gatgacgtaa
     1381 caagtggtgt taacgtagaa gttggtaaaa cacaagttgc agttgactta aacgttattg
     1441 ttgagtacca aaaaaatgtt ccagctttat attcagaaat cagagaaatc gtatcttcag
     1501 aagttgctaa aatgactgac ttggaaattg ttgaaatcaa cgtaaacgtt gtcgacatca
     1561 aaactaaaga acagcatgaa gcagactcag taagccttca agatcgcgta tctgacgttg
     1621 ctgaatcaac aggagaattc acttcagaac aattcgaaaa agctaaatct ggtcttggat
     1681 ctggtttctc aactgttcaa gaaaaagtta gcgaaggtgt agaagctgtt aaaggtgcag
     1741 caaatggtgt agtatctcac gaaaacactc gtgtaaacta agataaaata aatataacag
     1801 gagaaattat catgtcagta gaagaaaaat taaatcaagc taaaggttct attaaagaag
     1861 gtgttgggaa agccatcggt gatgaaaaaa tggaaaaaga aggagcagct gaaaaagttg
     1921 tttctaaagt aaaagaagtt gccgaagacg ctaaagacgc tgtagaaggt gctgtagaag
     1981 gtgttaaaaa catgcttcat aaagaagaga aataaggttt agactttata tattctttta
     2041 agaccaaaaa atcaggaaaa gccttggaat caaggctttt ttgatgttta tctccccttt
     2101 ttcatgatgt attttcgtac aggtgcttca accatttgaa cgatttcaaa tccttctttt
     2161 tggtaaagat tctgagctct ttgatttgcc tcgaagacat ttagagaaat actatctata
     2221 tcttcatttt caaaggccaa actaacaaat ttccttaaag cctggctacc taagtcttgc
     2281 tcctgcttct gggggttgat aaaaaatctc ccgatatgaa gattgctgtc ttctagcctg
     2341 attttctgga taagtcccac aaactcttgt tcatcaaaga ttgaaaagac tccttccaag
     2401 gcttgaaggg tcagtagaaa aggaatcctt ggtcccatcc attgttcttg aaagactttg
     2461 cctaaggagt tggaccattg gcatacgagc tgagcgtttt ctatactcac cttttcttca
     2521 aaacgaattg tcatcttttc ctcaccatct tatctatgtt tctccattat actatttctc
     2581 ccatttttta cgaatagata agtatgattg atttttattt ttttctcgtc gggagcattc
     2641 tcgcttcctt tcttggtttg gtcattgacc gttttccaga gcaatccatt atcagttcag
     2701 ccagtcactg cgattcctgt cagactcgct tgcgtccctt agatttgatt ccgattctct
     2761 cacaggtctt caatcgcttt cgctgtcgct actgcaaagt tcgctatcct gtctggtatg
     2821 ccctctttga actaggctta ggactcctct ttctgcttta ctcttgggaa ttgctttcct
     2881 tggggcaagt cgtcctaatc accgctggtt tgaccttggg tatctacgac tttcaccatc
     2941 aggaatatcc cttactggtc tggatgactt tccacctaat cctaatagct tcctctggct
     3001 ggaatctggt catggtctcc ttcctcatac ttggaatttt ggctcatttt attgatatcc
     3061 gcatgggtgc aggggatttc ctctttttag cttcttgtgc tctcgtcttt agcgtaacgg
     3121 agttactgat cttgattcag ttcgcttctg cgacgggtat cctggccttt ctcctgcaaa
     3181 aaaaaaagga aagacttcct ttcgtgcctt tcctcttact tgctacttgt ttgattattt
     3241 ttggtaagct actgcttgtt tgataaattc caatttctgc catatgtcct tcatgaaatt
     3301 atttcacagt taaattataa attatttctt ttgtacaaag ggatgatgtt atcaaatcga
     3361 tctgttcttc tatcttcttg atactgatca aaaaatttca tttcgactga aaatatttcg
     3421 cttataaact gtaaacgaat actttgttta gacattatag tcgctagact gactagatga
     3481 ttactcaaaa cgacgtccag aatactcttt actttgcttg gttttttaac aaaaatttga
     3541 tcatccaaag gttcaatcat tttgtaacct ttttgcgcaa tttgacgata aaagtaagaa
     3601 tgttgcttta gagacaataa tcctaactta aaagctcgat actctaaagc ctgtatcgaa
     3661 acattcaaat ccgacttcaa taaaatataa ctatcaggat tgctgacacg cttgccaacc
     3721 ctctcttcaa atttgactaa aaactcttct tttggcaata aaaaacatga tgcaaaataa
     3781 tttgcttctt gctccaaacg atcgccatct tcattcatat ctttatattt atgtaaaaga
     3841 atatgtccta gctcatgagc taagtcaaaa tttcgacgta cagatgattt attcgttccc
     3901 aacacaatat aaggtcttcc caattttgac catgcgctat aagcatcagc ttggccatta
     3961 attaatcgtt ccacgatata gatgcctgaa cgttctaatt tataaagcaa atcatgatta
     4021 tcttttgaaa tacctaattt ttccctggca taaagagcca attcctcaat ggattctccc
     4081 ttatgataag attcactcac tacattactt aagtcatgaa ttgtaatatt aggtataatt
     4141 acaaaacttt caaaataatc aatcaaacta tctaccttat gtaaatacat agtttgaata
     4201 tctattgttt tccgtgttgc taggtctgca tttctaaagg caattacaga agaatcaaat
     4261 cgaacgctct cttcttcctg ttcaaaataa gttaaatcaa catgaaattg gttggccaaa
     4321 tgcattttgg ttgataattt aggtttcgtt tcgttggact caaactgcca aatggcttgt
     4381 tccgttaaat taattctctg agctaattct gctctactta aaccatttaa cagccgtaat
     4441 tctttcaata cccgaccatt aaacatttac atactcctta ctacttttga ccttcttgtt
     4501 tttctattct tggaataatt tcaaaatctt ctgtttccga taattctgaa aaattaggaa
     4561 tatcttgata tttagcttct tcgaaatggt acgaacttga ttgaatatac tcagacaaat
     4621 cttgaatcaa gtgtaactga ccagttcgtg catcaggcat aacaacatct acagatataa
     4681 tattgttttc tgagtccgcc tcataagtta aaatcataaa tttttcgata ttcgaatttt
     4741 tagtagcttg ttcaatttct tgaatcattt catcagaaac taactccatc tgaattggaa
     4801 aggaatgact atcttcatca tttttgtagg aagaatgttg attaagataa agtgtattca
     4861 tctgagcata ttcaaataag tagccactct tatttttttg taccaaagga aattggttcg
     4921 taagtcgctt cttacccttt ataattaaca atactttccc atatttttct gtgtttgttt
     4981 caaattctaa atatccaagt ctgtcctgct aattgtaatt tatactcaaa caaatctgct
     5041 gatgcaaatg cagtatcaat atgattaggt cgcgtccatg cataaccatt cgacactatc
     5101 attgtctctc ttttttctag acgttcatct acataatctt tttgcccttt catcaaagta
     5161 tctacaattt tttgtgcctc aagcgaatca aagagatcct gattcaacat aattcttcct
     5221 cctccaaata ctttttaatg aattatatca ttttcttaaa gaaattacta caataattag
     5281 ctttttctta aagttctgtg tcagagtaat ttagaaaatt atatcttcta tagtaaaatc
     5341 aattaaaaac tgaacaaatt tattgggaaa ttcaaatcgc tttctgaaaa tattttagga
     5401 accgtagtgt aatattccag attcaattca ctataaaact agcctttctc ctgcaaaaga
     5461 aaaaggaaag acttcctttc gtgcctttcc tcttacttgc tacttgtttg attatttttg
     5521 gtaagctact gcttgtttga taaagtcctg aatcggctct ccttggtgga gagcttttac
     5581 tattttcgaa ccgacgataa caccatctga caccgcattg aagcgttcca gatcgacttg
     5641 actagataca ccaaaacctg tcaagactgg gatgtcggcc acttgatgaa gttgcgccaa
     5701 gtgcttgtcc aaatctgcac ggtaattgcc tgatttccct gttaccccat tgatggcaac
     5761 ggcatagacg aatccctccg ccccttcaat caactctttc tggcgctcaa ttcctgtggt
     5821 caagcttact aaaggaatca aggcgatatc tgtatctgcc aaaaatggtt ctacaaagtt
     5881 ggcatgttca tgaggcaggt ctgggataat caagcccttc acagctgtat cagccagatc
     5941 tttgacaaag ttctccacac cgtactgaaa gagggggttg aagtaggtca tgatgaccag
     6001 tggaatctct gtttcaatgg ttttcaaggt ttcaactaaa gcctgggtag aggtcccgtg
     6061 ggctaaactg cgcaagccag cttcttcgat aacaggtcca tctgcaacag ggtctgaaaa
     6121 gggaataccc acttcaattg cagagacacc caaatcttct aaaaagtgaa ttgtttcagc
     6181 aagaccatcc aaaccttttt cgtggtcacc agccatgata tagggaacaa aaattccttt
     6241 tccagctgct ttaatagcat ttaatttttt tgttagtgtc ttaggcatga gcttctccct
     6301 tctttgctgc atctgcttcc aagcggtcct tgacttgaac cacatccttg tccccacgac
     6361 ctgataggca gacaatcata gacttttctg gtccaagttc tttggccaat ttcaccgcaa
     6421 aagcgatagc atggctagat tccaaagctg ggataatccc ttccacacga gacaagagtt
     6481 ggaatccttc caaggcttct tcgtctgtca cagggacata gctggcacgt ttaatatcgt
     6541 ggtagtgaga atgctctgga ccgataccag gatagtccaa acctgctgag atagagaagg
     6601 cttcaagaat ttgaccatgg gcatcttgga gcacatccat gagggaaccg tgaaggacac
     6661 ctggacgacc cttggtcaag gtagctgcgt ggtactccgt atccacacca aatccagccg
     6721 cttcagctcc atacatggct actgactcat cttctacaaa gggatggaag agaccgatgg
     6781 cattcgaccc accaccaaca caggctacta gggcatctgg cagattttgt cctgtcaagt
     6841 cacggtactg ttgtttagcc tctcgaccaa tgacactttg gaagtcacga acaatttctg
     6901 gaaatggatg aggccccaag gcagaaccaa ggatatagtg ggtatcatct atattagcca
     6961 cccatgaacg aagggctgca ttgaccgcat ccttgagcac gcgcgaacca tctgtcacgg
     7021 cctcgacctt agctcccaaa agctccatac ggaagacatt gagggcttgg cgtttgacat
     7081 cttcctcacc catgtagatg gtacattcca tgttaaagag ggccgcagca gttgcagttg
     7141 ccacaccgtg ctgaccagca ccagtttctg cgataatttt ctttttaccc atgcgtttgg
     7201 caagccaaac ttgtcccaag gcattgttaa tcttgtgggc tcctgtatgg ttaaggtctt
     7261 cccgtttgag ataaatcttg gctccgccga tatgctgggt caagtttttt gcgtagtaaa
     7321 ggggagtttc acgtcccacg tactggcgca aaagctggtt taattcctct tggaaacttg
     7381 ggtctgcctg actttcacgg taggccttct ccaactccaa aactgctgtc atcaatgttt
     7441 ctgggacaaa acgtccgccg aattttccgt aaaatccatc tttatttggt tcctgatatg
     7501 ccatgcttta ccctctctat aaatcttcta atcttttcat gatctttttg tccatctgtc
     7561 tccactccgc tcgatacatc tactgcatag ggagtaaaat gttgaattgc ttttactaca
     7621 ttatcttcat taaggccacc tgcgataaag aagggctgtg ctagtccagt cgtatccagt
     7681 tgaccccaat caaagggctg gccacttcct gccacagggg catcaaagag tagataatct
     7741 gcctgagaat tggggacatg cccatttcca tctacctgca cagcctgaat actggcacaa
     7801 ggcaaattct caaataaatc atctgccacc tgaccgtgaa cttgaaccaa gtccaagcca
     7861 actttgtcaa tcgcttccag cagttctacc cgacttggtg aaacaaatac tccaaccttt
     7921 ttcacatctg caggaataag ctttgccaac tcagctgcct cttctaaagt cacctgtctt
     7981 ttactaggtg caaagacaaa accgatatag tcggctcctg ctgaaacggc tgtttccacc
     8041 gcttctttgg tcgatagtcc acaaatttta acctttgtca atctgcaact ccttgattct
     8101 ctgggccaca ttttctgcct gcataagagc tgtccctacc aaaattccgt taaagtatgg
     8161 ggctagtcgt tccgcatcct gccctgtgaa aatggcagat tcagaaatgt aatagcgacc
     8221 ttcctcaaag taaggggcta aatctacact ggtctgcaag tcgacctcaa aggtagtcaa
     8281 gttgcggttg ttgaccccga taatctcagc accaagtctg tgggctacct ctagttcagc
     8341 tagattgtga gtttccacca agacttccag accaagctct gtcgcgtagt catacagttt
     8401 cttgaggcgt tcttcggaca aggctgccac aataagcaag ataactgtcg cacctgcatt
     8461 gcgagcgcgg atgatttgct tttcatctat gataaagtct ttgttgagcg tcggaatctc
     8521 tacctgactg gaaatctccc gtagataatt caaatgccct ttaaagaaaa cctcatctgt
     8581 caacaccgaa atcatcactg ttccgttttc ttcataagtc tgggcctgtt gcacaatatc
     8641 cacatcgaga ttgatatctc ccaaactagg gctagctttc ttgacctcag cgattacctg
     8701 caagcggtcc tgatgattct tcaaaaattc tgccaagcga taggtctggc gcagaggctg
     8761 gatttgctcc agcttcatct gctccacctc acgcgccttc tgctctaaga ttcgtgctaa
     8821 aaattcctga ctcatttttg gtactcctgt aacagtctga gtttttcaag ggccttgcct
     8881 ctagcaatca cttgacgggc caaggcaact ccttccttga tgctatcaat cttaccatta
     8941 gcatagaaac caagaccagc attcaagact gtcgtttcca agaatggact tgcttcgttt
     9001 ttcagaacgc taagcaaaat ttctgcattt tcctgagcat tcccaccacg aatatcttcc
     9061 atagcatagc cttccattcc caaatcctct ggagtaaagc ttgacaagct gatttcgcca
     9121 ttttcaagaa gtgcaatctt ggttgttccg ttcaagccag cttcatccaa cccttctggt
     9181 ccagcaacca cgatggcacg tttgcgaccc atatttttca aaacctgagc tgtactttct
     9241 aggagttctg gacgactaat tccaagaagc tgtgtttcta aagccattgg atgaatcagt
     9301 ggaccagtca agttcataat cgttggaatt cccaattcca aacgagctgg catgatgtat
     9361 ttcatagctg ggtgcatatt tttagcgaag agaaagacga ttccagtttt atcaaagacc
     9421 ttacctagtt cagctggttt gaggtcaaga ttgattccca aggcttcgag gacatctgcg
     9481 gaaccagatt tagaagatat cgagcggtta ccgtgtttgg ccatgtgaat accgccacca
     9541 gccaagacaa aggctgcagt tgtggaaata ttaaaactga aagacttgtc cccacctgta
     9601 ccacagttgt ccatggcatc atgaatctca gttggaatat gctgggcatg tcctctcatg
     9661 acttgggcaa tggctgtgcg ttcttcaggt gtttccccct tcatcttaag agctaagagg
     9721 agagaagcaa tctgcgcttc agttacacgc ccagttacga tacgctcaat gacatccgtc
     9781 atttccacac ctgataaatt ttcaaatttt gctagttttt caataatctc tttcatccta
     9841 gtttcctcac tttacaacct cctcgataaa attccgaata gaagacaagc cgtctggcgt
     9901 tccaatgctc tctggatggt actggaagcc ataaatcggt aggtttttat gttgaatccc
     9961 catgatggct tggtcatcag tcgaacgagc tgtcacttca aagtcttctg gcatttcctc
    10021 aatcaaaata ctgtgataac gcatgaccgc acgtccatcc tcaatacctt gatacaaaac
    10081 agatggcgct tcaaagttga tattgctctg tttcccatgc atgacttttg gagccaaacc
    10141 tagcttacca ccaaagactt ctgcaatggc ttggtggccc aaacaaatcc ctagaatcgg
    10201 cttcttgcct gcaaaatcac gaatcatgtc ttccatcttt ccagcatcaa ctggccaacc
    10261 aggaccagga gaaaagacca gaccatctgc tttttcagct tcttcataca gcttggaatc
    10321 atcatttctc agaacctgaa cttctgcaaa attcccaatg tattgggcca agttataggt
    10381 aaaagaatca tagttgtcaa tcaataaaat catggtctta gttctccaat tctagtcata
    10441 gattttgctt tgttaatggt ttcttggtat tcgttttggg cgatagagtc gtagacaatc
    10501 cctgccccag cctgcacata ggctctttga tttttgagaa tcatggttcg gatggcaatg
    10561 gccaaatcca tatcacccgt cgcagacaag tagccgattg ctcctgcata tacgccccgt
    10621 ttttccgttt ccagttcata gatgcgtctc atcgcccgaa tctttggtgc tccagaaacg
    10681 gttccagcag gaagtgtagc tttcaaggca tccatggccg tgagttctgc aagcaaacgc
    10741 cccttgacca cgctggtcaa atgcatgacg tagcggaaga gctccacctt catatactta
    10801 gtaacttgga cactggccgt ttcagagatg cggccaatat cgttacgccc caagtctacc
    10861 aacattcgat gttctgctgt ttccttctca tcagagagga ggtcagtcgc caaggtcttg
    10921 tcttcttcat ccgtagcccc tcttggtcgc gtccctgcaa tcggattggt tgtcacgatg
    10981 ccatttttga cagaaactaa actttctgga ctagctccga tgatttgata atccccaaaa
    11041 tcatagaaat aaaggtaatt agaaggatta gtcacgcgga gatttctgta gaagtcaaat
    11101 ggatttccag taacttctgc tgagaaacgc tggctgagta cacattggaa catatcacca
    11161 ttacgaatca agtcacgagc tgtttctacc attacctcaa acttatgtgg agcgatatgc
    11221 ggtttgaagt caagtggtga taaatccaag tcttcaaatt catttggagc aggaatgcgt
    11281 aattcctcaa gcacttggtt caaggatttt tccaaggcct cttgactgcg ctcactatag
    11341 agagcatcct ctatgacatg tatcttctcc ttcttgtggt caaagaccat atagctctca
    11401 tagacaaaga aatgcatgtc tggcgtccca attgtatcct cagggatttg accaatttct
    11461 tcataaagcg aaatcatatc gtaacccaca aaaccaatgg ctccaccacc aaacgggagc
    11521 tctgagtggt gctgactctt atgaatcact tcataaagga aatccaaggg atcccgatca
    11581 atcacttgac cattttgata gagaactcca ttttcaaact taatctcaaa aactggatta
    11641 taggctagga tagaaaaacg agctgtttcc ttgtctctcg gaatactctc taaaataacc
    11701 ttgtgttgcc cctttaagcg catgtaagcc aagattggtg ataagacatc tccatgaatg
    11761 attcgttcca ttgtaatttc cctttcagtt ctacttatag tccgtagcga ctgtatgaaa
    11821 aatccccacg caaaataact tgcgtgagga cgaaattcgc ggtgccacct caattatagg
    11881 atttctccta tctctcattc ctgtctcaga tatctcctgt aacaggctgt gcgataaagg
    11941 gcactccctt gagaatgatg ttttcttctc tcgtttcaga tgaacccaac tttacagctt
    12001 tctctgcttg tttccagcaa ccacaagctc tctgtgagag aaagaactgt aatttttcca
    12061 tctattattt tttagcttct aggtagtctg caatcgcagc taggtccttg cctccacgac
    12121 cagagacatt gatgaagaga tgttcatctc ggtacacctt tatactcttc gaaaatctct
    12181 tcaaactgcg tcaacgtcgc ctttccgtag gtatggttac tgacttcgtc agttctatct
    12241 gcaacctcaa aacagtgttt tgagctgact tcgtcagttc tatccacaac ctcaaaacag
    12301 tgttttgagc agcctgcggc tagtttccta gtttgctctt tgattttcat tgagtattac
    12361 tagctttttt cgtattagtc cagccttttt gtttgctttt agtagtaggc aaggagctgt
    12421 agatagaact caagttcatc aaagcgactt aaggccctaa taaaagataa accaaacgac
    12481 ggatagaaaa aagcccacac acagaatata cttccgtgtg agggcgttgg taacgcggtg
    12541 ccacctcaat tataaaggga ctatcccttt acatctctgc cttgtttaac aacaagctgc
    12601 actgtaaggt gtgcgcaccg aattttcatt gtttcaaatt cattttcaaa atcagcccac
    12661 tttcactact tccaaccacc tattcacaat caccacaggc tccctgaaga tcaaaaatag
    12721 ttacttttct gatttgttga acttatttta atactttgtt ttttctttgt caagactttt
    12781 ttacgatttt tttgaaaata tcattcgaat gtgaccatgt cttccttaga tcgaacatga
    12841 acatgtccca cttgttagaa attggatcca actcaataga aactgaatgg aggctaaaca
    12901 gaacttattt tagaacactc catcttttcc actaggattt tcaagaatta aacaatacta
    12961 gaaactctgt ctcctaacaa atttaggaga aacttcaaca gatgtgacac tttccccttt
    13021 aataattgct aaaacacctt ctatcatttc tttagccaat ttaacataat tgggagcaat
    13081 tgtagacaaa gctggagtat aatactgaga aataggaata ttatcaaatc caatgataga
    13141 aatatcatct ggaataagaa ttcctttctc atagcacgca cgaatcaagc cctgaacctt
    13201 ttcatctcct gaaacaaaaa taatgtccgg ataattttgg gtagtcaagt gctgcattgc
    13261 ataagaataa actgaatcaa ttgtagataa gccataaatg acttttaaat ccataaagta
    13321 atttttatca ttcagaaaag aacgcacacc tctttcacga tccttattaa catgggattc
    13381 tcctcccata agcaaccaca tatttttaaa tttttcttca gttacagctt tcatcatatc
    13441 ataagtagct tgaaaattat tattagatac atagactact ccagacgttt gagattcacc
    13501 gaaaacaaga aaaggcatat ggttcttctt taaatactga attctgatat catctacact
    13561 ttcataaaaa acaataacac catctactag gctacctgtg cttgatataa ttgaattact
    13621 aattgtatcc tcctctccaa agtactcaac tatagcatta acaccaaatt ctttacacgt
    13681 ccgtaacact ttatctaaca gcgtatgaaa ccaaattaaa ggaaaagagt cgattttttt
    13741 tacagaaatc aatatattta tagcttcttt tttagttaaa ttttttgcat acgcatttgg
    13801 aatatacgac aattcctcta taactttttg aatcgcttga taagtttctt ctttaacatt
    13861 tactccacca ttaataactc gtgaaactgt ttttggagaa aaacctgata aacgtgcaat
    13921 atcataaata gttacctttt tcccatttat atttttcatt tcagtcctcc a
//
LOCUS       DAVHSO010000058        13436 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.059, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000058 DAVHSO010000000
VERSION     DAVHSO010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13436)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13436)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13436
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.059"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(253..1152)
                     /gene="htpX"
                     /locus_tag="VVR18_001756"
     CDS             complement(253..1152)
                     /gene="htpX"
                     /locus_tag="VVR18_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease HtpX"
                     /protein_id="HEU6033238.1"
                     /translation="MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLV
                     IALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRVFI
                     IDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
                     ALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLV
                     QLAISRQREFLADASSVELTRNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKG
                     GGFQKLFYTHPPISERIERLKHM"
     gene            complement(1154..1714)
                     /locus_tag="VVR18_001757"
     CDS             complement(1154..1714)
                     /locus_tag="VVR18_001757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LemA family protein"
                     /protein_id="HEU6033239.1"
                     /translation="MTWIILGVLALVVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRR
                     NDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMKASDALTRQVSGIFAV
                     AESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMFG
                     FKAADFLQTPEEEKSVPKVDFSGLGD"
     gene            1808..2521
                     /gene="rsmG"
                     /locus_tag="VVR18_001758"
     CDS             1808..2521
                     /gene="rsmG"
                     /locus_tag="VVR18_001758"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HEU6033240.1"
                     /translation="MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAI
                     TDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGAGFPSLPMKILYPELDVTIIDS
                     LNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT
                     IPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKK
                     KETPNKYPRKAGMPNKRPL"
     gene            2775..4058
                     /locus_tag="VVR18_001759"
     CDS             2775..4058
                     /locus_tag="VVR18_001759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007554578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HEU6033241.1"
                     /translation="MKQESTVDLLLDVDQRPSDGKGILLSFQHVFAMFGATILVPLIL
                     GMPVSVALFASGVGTLIYMIATGFKVPVYLGSSFAFITAMSLAMKEMGGDVSAAQTGV
                     ILTGLVYVLVATSIRFVGTKWIDKLLPPIIIGPMIIVIGLGLAGSAVTNAGLVADGNW
                     KNALVAVVTFLIAAFINTKGKGFLRIIPFLFAIIGGYLFALTLGLVDFTPVLEANWFE
                     IPGFYLPFSTGGAFKEYNLYFGPEAIAILPIAIVTISEHIGDHTVLGQICGRQFLKEP
                     GLHRTLIGDGIATSVSAFLGGPANTTYGENTGVIGMTRIASVSVIRNAAFIAIALSFL
                     GKFTALISTIPNAVLGGMSILLYGVIASNGLKVLIKERVDFAQMRNLIIASAMLVLGL
                     GGAILKLGPVTLSGTALSAMTGIILNLILPYENKD"
     gene            complement(4253..5824)
                     /gene="ffh"
                     /locus_tag="VVR18_001760"
     CDS             complement(4253..5824)
                     /gene="ffh"
                     /locus_tag="VVR18_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HEU6033242.1"
                     /translation="MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADV
                     ALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPT
                     IIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
                     FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEI
                     LLVVDAMIGQEAANVAREFNAQLEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGT
                     GEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMAEKMRENTFDFNDF
                     IDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPD
                     LLNPSRRRRIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLP
                     KNMPNMGGMDMSALEGMMGQGGMPDLSALGGAGMPDMSQMFGGGLKGKIGEFAMKQSM
                     KRMANKMKKAKKKRK"
     gene            complement(5836..6168)
                     /locus_tag="VVR18_001761"
     CDS             complement(5836..6168)
                     /locus_tag="VVR18_001761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009660419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HEU6033243.1"
                     /translation="MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEE
                     FGVSRQAVYDNIKRTEKILEDYEMKLHMYSDYIVRSQIFDQILERYPKDDFLQEQIEI
                     LTSIDNRE"
     gene            complement(6258..6635)
                     /locus_tag="VVR18_001762"
     CDS             complement(6258..6635)
                     /locus_tag="VVR18_001762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HEU6033244.1"
                     /translation="MKIRMRNTIQFDEQLEVIDRLYDVEVHEKGDYSYLLFYNEEKEK
                     VVIKFHGQELVMSRFSNPKTIMRFLKDSDSLAYIPTPMGMQEFIIQTSRYQVDRQKIE
                     LAYQLQNQEGHPFASYQLEITWG"
     gene            6707..8011
                     /locus_tag="VVR18_001763"
     CDS             6707..8011
                     /locus_tag="VVR18_001763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HEU6033245.1"
                     /translation="MNEKVFRDPVHNYIHVNNQIIYDLINTKEFQRLRRIKQLGTSSY
                     TFHGGEHSRFSHCLGVYEIARRITEIFEEKYPEEWNPAESLLTMTAALLHDLGHGAYS
                     HTFEHLFDTDHEAITQEIIQNPETEIHQVLLQVAPDFPEKVASVIDHTYPNKQVVQLI
                     SSQIDADRMDYLLRDSYFTGASYGEFDLTRILRVIRPVENGIAFQRNGMHAIEDYVLS
                     RYQMYMQVYFHPATRAMEVLLQNLLKRAKELYPEDKNFFARTSPHLLPFFEKNVTLTD
                     YLALDDGVMNTYFQLWMTSPDKILADLSQRFVNRKVFKSITFSQEDQDQLTSMRKLVE
                     DIGFDPDYYTAIHKNFDLPYDIYRPESQNPRTQIEILQKNGELAELSSLSPIVQSLAG
                     SRHGDNRFYFPKEMLDQNSIFASITQQFLHLIENDHFTPNKN"
     gene            8024..8830
                     /gene="yidA"
                     /locus_tag="VVR18_001764"
     CDS             8024..8830
                     /gene="yidA"
                     /locus_tag="VVR18_001764"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000023490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HEU6033246.1"
                     /translation="MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATG
                     RPIAGVAKLLDDLQLRDQGDYVVTFNGALVQETATGHEIISESLTYEDYLDMEFLSRK
                     LGVHMHAITKDGIYTANRNIGTYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPE
                     ILDAAIEKIPAEFYERYSINKSAPFYLELLTKNVDKGSAITHLAEKLGLTKDETMAIG
                     DEENDRAMLEVVGNPVVMENGNPEIKKIAKYITKTNDESGVAHAIRTWVL"
     gene            complement(8886..8957)
                     /locus_tag="VVR18_001765"
     tRNA            complement(8886..8957)
                     /locus_tag="VVR18_001765"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(8922..8924),aa:Arg,seq:cct)
     gene            complement(9000..9347)
                     /gene="rplS"
                     /locus_tag="VVR18_001766"
     CDS             complement(9000..9347)
                     /gene="rplS"
                     /locus_tag="VVR18_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HEU6033247.1"
                     /translation="MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFE
                     GVVIARKGAGISENYTVRKISNGVGVERIFPIHTPRVEKIEVVRYGKVRRAKLYYLRA
                     LQGKAARIKEIRR"
     gene            complement(9466..9795)
                     /gene="crcB"
                     /locus_tag="VVR18_001767"
     CDS             complement(9466..9795)
                     /gene="crcB"
                     /locus_tag="VVR18_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HEU6033248.1"
                     /translation="MVIVYLAIACGFGALVRYLFSRYNQASKLPLGTLIANLLGCFLI
                     GVFYNHVESKEVYAILATGFCGGLTTFSTLNDELQRLLSDKKVFYSYLTLTYIGGLVA
                     IFLGILL"
     gene            complement(9789..10163)
                     /gene="crcB"
                     /locus_tag="VVR18_001768"
     CDS             complement(9789..10163)
                     /gene="crcB"
                     /locus_tag="VVR18_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HEU6033249.1"
                     /translation="MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNY
                     LGIFCLIFLFKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYFSLV
                     LYLLLSIGGGLLLAYFLGRKKW"
     gene            complement(10160..10426)
                     /locus_tag="VVR18_001769"
     CDS             complement(10160..10426)
                     /locus_tag="VVR18_001769"
                     /EC_number="5.4.99.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate mutase"
                     /protein_id="HEU6033250.1"
                     /translation="MDLDIIRQEIDQIDDQIVKLLEERMHLVEGVVAYKKASGKPILD
                     TKREEVIFEKVGSRVEDKRYQETIVATFSDILKRSRDYQDQNIK"
     gene            complement(10542..10985)
                     /locus_tag="VVR18_001770"
     CDS             complement(10542..10985)
                     /locus_tag="VVR18_001770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HEU6033251.1"
                     /translation="MALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDAS
                     DFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAV
                     DDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELVAKVG"
     gene            11089..12024
                     /locus_tag="VVR18_001771"
     CDS             11089..12024
                     /locus_tag="VVR18_001771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HEU6033252.1"
                     /translation="MEICQQILEKIKEYDTIIIHRHMKPDPDALGSQVGLKALLEHHF
                     PEKTIKAVGFDEPTLTWMAEMDLVEDRAYQGALVIVCDTANTARIDDKRYSQGDFLIK
                     IDHHPNDDVYGDLSWVDTSSSSASEMITLFAQTTQLALADRDAELLFAGIVGDTGRFL
                     YPSTTARTLRLAAYLREHNFDFAALTRKMDTMSYKIAKLQGYIYDHLEVDENGAARVI
                     LSQEVLKQYNVTDAETAAIVGAPGRIDRVSLWGIFVEQADGHYRVRLRSKIHPINEIA
                     KEHDGGGHPLASGANSYSLEENEIIYQKLKNLLKN"
     gene            12078..12362
                     /locus_tag="VVR18_001772"
     CDS             12078..12362
                     /locus_tag="VVR18_001772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="HEU6033253.1"
                     /translation="MARKETMAERKYCKMKKDIHPEYRPVVFMDTTTGYQFLSGSTKR
                     SNETVEFEGETYPLIRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLK"
     gene            complement(12419..12637)
                     /locus_tag="VVR18_001773"
     CDS             complement(12419..12637)
                     /locus_tag="VVR18_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033254.1"
                     /translation="MSISPRFETLEQAIASKDLEKVREAFKKMNSTWTINESVVRDNS
                     TAHYGRVETAISFLPSSMETEPTDESGT"
     gene            complement(12634..13436)
                     /locus_tag="VVR18_001774"
                     /pseudo
     CDS             complement(12634..13436)
                     /locus_tag="VVR18_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
BASE COUNT         3986 a         3042 c         2493 g         3915 t
ORIGIN      
        1 gtcgcttttc attataggtc atatgggact ttttttctac acaaaatagg ctccataata
       61 tccatagggg ggttacccac tacaaatatt atagagcctt ataaatttgc aacatagcag
      121 ataggtgggg caaaaacaca attttaggag aaaaagaagt aaatcttccc atagtaaaac
      181 gcataatatc aagttttcac acctgatatt atgcgttttt cagattttaa agactttttt
      241 ccagccttca ttttacatat gttttaaacg ttcaatccgt tctgagatag gtgggtgggt
      301 ataaaagagt ttttggaacc ccccaccttt cttgggatca ttgatataaa gggcactgct
      361 agcatcatcg acgtggcgac tcataggttt gctattgtcc aacttatcta gggcattaat
      421 cattccctgg ggattgcgag tcagctcgac actagatgca tctgccagaa attccctctg
      481 acgagaaata gcgagctgaa ccaaggttgc agcgagaggt gccagtacaa tagctagtag
      541 ggaaaccact agcataatga tttcaagacc atttccatct cggtcatcat cacttcgtct
      601 gcgacctgct ccaccccacc acatcatacg acctgccata ctagaaagca tggtgatagc
      661 actagcaagg gcaactgcaa tagtcgaaat acggatatca taattacgaa tatgactgac
      721 ttcatgtccc ataacagctt ctagttcttc acgattcatg atagctagta gacctgaagt
      781 cgcagcaaca gccgcatttt gaggattaga acctgtcgca aaggcattta aggctggatc
      841 atcaatgatg aaaacacggg gcataggaat ctgagcgacc agagccatat cttccactac
      901 atggtagagg tctggtgccg tttgctcatc cacctcacgc gctccattca tggacatgac
      961 aatctctgtc gattgaaaaa tcatagacaa agcgtagata aagccgataa tcagtgcgat
     1021 aaccaaacca ccaagtccag atcttataaa gagataacca accgcataac caacaagagc
     1081 taagagtagg aaaaatacca gcaacaaaat ccaggttttt cgtttattgc ttgcaatttg
     1141 atcaaacaac atcttagtca cctaaaccgc taaaatcaac tttaggaacc gacttttcct
     1201 cttcaggtgt ttgaaggaaa tctgccgctt taaatccaaa cattccagcg ataatattgc
     1261 tcgggaaagt ttctaatttt acattgtagt tgctgacaac actgttatag agttgacgag
     1321 agtaagaaat tttattttct gtatttgtca actcctcttg caatttaaca aagttagcac
     1381 tagctttcaa atctggatag ctttctgcaa ctgcaaaaat acctgaaacc tgacgagtga
     1441 gggcatcact ggctttcata gcttctgctg gtgaagtcgc tgccgccact tggttacgta
     1501 gttctgccac cttttcaagg gtagaacctt catatttggc ataacctttt acagtctcaa
     1561 tcaagtttgg caagagatca ttgcgacgtt ttaactgaac atcaatctga ctccaagcct
     1621 ccttggtttg catacgattt ttaaccaaac cgttatagct aacaatcaca aaaataacaa
     1681 caagagctaa aactccaaga ataatccaag tcataatata agtcctttct gcttttagat
     1741 tagtaccagt atatcaaatt ttctatgatt gtggtaaaat aagatgatac taaagaagga
     1801 aataactatg aaaccaaaaa cattttacaa cttgcttgcc gagcagaatc ttccactttc
     1861 ggaccagcaa aaagaacaat ttgaacgtta ttttgagctc ttggtcgagt ggaatgagaa
     1921 gattaatttg acggcgatta cggacaagga agaagtttat ctcaaacatt tttacgattc
     1981 gattgcaccc attcttcaag gtttgattcc caatgaaact atcaaacttc ttgatatcgg
     2041 ggctggggca ggatttccta gtctaccaat gaaaattctc tatccggagt tagatgtgac
     2101 cattattgat tcactcaata agcgcatcaa cttcctacaa ctcttggctc aagaactgga
     2161 tttgaacgga gttcatttct accacggacg tgccgaagat tttgcccaag acaagaactt
     2221 ccgtgctcaa tatgattttg taacagctcg tgcggttgcc cgtatgcagg tcctatctga
     2281 attgactatt ccctacctta aggttggtgg caaactattg gcactcaagg ctagcaatgc
     2341 gcctgaggaa ttattagaag ctaagaatgc cctcaatctc ctttttagta aggtcgaaga
     2401 caatctcagc tacgccctac cgaatagaga tccgcgctat atcacagtgg tagaaaagaa
     2461 aaaagaaaca ccaaataaat atccacgtaa ggctggtatg ccaaataaac gcccacttta
     2521 aattttttag taaacaaatg tttacaaaat cagcctcgct cttttatttc taggctcggg
     2581 aaaaaatgat ttacaaaatc atttttttct gctatactat cctaagcaaa ggtttttaat
     2641 gtcatcccgt gaggtgacga agacgcagaa atatttaaaa ctctttaaaa tctaaatttt
     2701 aaagaagtct tactctgagg gcctattgct gtaaaataat gggctctttt ctgatgccca
     2761 aaagtgaggt ttatatgaaa caagaatcaa ctgttgattt gttactagac gttgaccaac
     2821 gtccttcgga tggaaaagga attctcctta gcttccaaca cgttttcgcc atgtttggtg
     2881 cgaccatctt ggtaccattg attttgggaa tgcctgtatc tgttgccctt tttgcttcag
     2941 gtgttggaac actcatctac atgattgcta ctggttttaa agttccagtt tatctaggtt
     3001 cttcatttgc ctttatcaca gctatgtcac tggctatgaa agaaatgggg ggggatgtat
     3061 ctgctgccca aacaggggtt atcttgactg gtttggtcta tgtccttgtt gctaccagca
     3121 tccgatttgt aggaacaaaa tggattgata aactcttgcc accaatcatt atcggtccta
     3181 tgatcatcgt tatcggtctt ggacttgcag gttcagctgt taccaatgca ggtcttgtag
     3241 cagacggaaa ttggaaaaat gctctggtag ccgttgttac tttcctaatt gctgccttta
     3301 tcaatacaaa aggaaaaggc ttcctacgaa tcattccatt cctctttgcc attatcggtg
     3361 gttacctctt cgcactaact cttggtttgg ttgactttac gcctgtccta gaagctaact
     3421 ggtttgaaat tcctggtttc tacttgccat ttagcacagg tggtgccttt aaagagtaca
     3481 atctttactt tggtccagaa gccatcgcta tcttgccaat cgctatcgta acaatttctg
     3541 aacatatcgg agaccatact gttttgggtc aaatctgtgg ccgtcaattc ttaaaagaac
     3601 caggtcttca ccgtactctt attggtgacg gtatcgcaac ttctgtttcc gccttccttg
     3661 gtggaccagc caatacaact tacggagaaa atacaggggt tatcggtatg actcgtatcg
     3721 cttctgtctc agttatccgt aacgctgcct tcatcgcgat tgccctcagc ttccttggta
     3781 aattcactgc cttgatttca actattccaa acgctgtact tggtggtatg tcaatccttc
     3841 tctatggggt tatcgccagc aatggtttga aagtcttgat taaagaacgt gttgatttcg
     3901 ctcaaatgcg aaacctcatc atcgcaagtg ctatgttggt tcttggactt ggaggagcta
     3961 tccttaaact tggtccagtt acactttcag gtactgccct ttcagccatg acaggaatca
     4021 tcttgaactt gatcttgcca tacgaaaata aagactaaga gtctaaatac acctaatcca
     4081 ctcagacagc tgagtggatt tttcgtatac cataataaaa gtgtcttaac aaagttatta
     4141 aaatcaaaaa acgtataata tcagatattc taaaaccttg atactgtacg ttttatcata
     4201 gaaattttta ctttattttc tcatcaaatg agatttgcat caatctcttg tcttacttgc
     4261 gtttcttctt cgctttcttc attttgttag ccatacgttt catggactgt ttcatagcaa
     4321 attcaccaat tttacctttc aaaccgccac caaacatctg gctcatatct ggcattcctg
     4381 ctcctccgag agctgataag tcaggcatac cgccttgtcc catcattcct tcaagggcag
     4441 acatatccat tcctcccata tttggcatat ttttaggaag gttatttgga ttaatcccca
     4501 tttgcttcat cattttattc atatccccag acataacacc ctgcatgagc tgtttagcct
     4561 ggttaaagtc cttgatgaat ttattgactt cgacgaatgt atttccagaa ccagcagcaa
     4621 tacgacggcg acggcttgga tttaacaaat ctgggttttc acgctcttca ggtgtcatcg
     4681 aagacacaat ggcacgttta cgagcaatct ggcgttcatc caccttcatg ttttgaaggg
     4741 ctggattgtt tgccatacct ggaatcatct tgagcaagtc ttccatcggc cccatatttt
     4801 gcacctgatc taattgatcg atgaaatcat taaaatcaaa ggtgttttcg cgcatcttct
     4861 cagccatttc aagggctttt tgttcatcgt attcctgaga agctttctca atcaaagtga
     4921 gcatatcccc cataccaagg atacggctag acatgcggtc tgggtggaag gtttcaatgt
     4981 ccgtaatctt ttcacctgta ccagtgaact tgattggttt tccagtaatg tgacgaacag
     5041 acagagcagc accaccacga gtatcgccat caatcttggt aaggatgacc ccagtcactt
     5101 ccaactgagc attaaactca cgcgcaacat tggctgcttc ctgaccaatc atagcatcaa
     5161 cgacaagcaa gatttcattt ggttgagcca atgctttcac atcacgaagc tcattcatga
     5221 ggagctcatc aatctgcaaa cgacccgcag tatcaatcaa gacatagtcg ttatgattag
     5281 tttgggcttg ctccaaacct tgacgtacaa tctcaacagc tggtacttct gttccaagtg
     5341 caaagacagg cacatcaatc tgttgtccca aggtcttaag ctggtcaatg gcagctggac
     5401 gataaatatc cgccgcaatc atcaaaggac gagcattttc ttctttcttg agtttgttgg
     5461 ccaatttacc agcaaaggtt gttttaccag ccccttgtaa accaaccatc atgatgatgg
     5521 ttggaatctt aggtgacttg ataatttctg ccgtatcaga acctaaaacg gctgtcagtt
     5581 cctcatcaac gattttaata atctgttgcg caggattaag tgtatcaatg acctcatgcc
     5641 cgactgcacg ctcacgaact ttcttgataa agtcctttac aacaggcaag gcaacgtcgg
     5701 cctcgagcaa ggccaagcga atttctttgg ttgcctcttg gacatcagat tcagagattt
     5761 ttcctttttt acgtagattt ttaaagacgt tctgcaaacg ttctgttaaa ctttcaaatg
     5821 ccatttttct tcctcttatt ctctattatc aatgcttgtt aaaatttcta tctgctcctg
     5881 cagaaaatca tccttgggat agcgctccaa gatttggtca aaaatctgac tacggacaat
     5941 gtagtccgag tacatgtgca atttcatctc ataatcttcc agaatctttt ctgttcgctt
     6001 gatattgtca tagacagcct gacgactaac accaaactcc tcagctatct cagcaagact
     6061 gtaatcatca gcgtagtaaa gctctatata attcatttgc ttatctgtca aaagcgccgc
     6121 ataaaattca aagagcgcat tcatacgatt ggttttttcg atttccataa cttttattat
     6181 accaaaaaat agcctaatct accacactag ggagccaatc cttgaagata gaaagtagat
     6241 ttgagaaaaa cgagatccta gccccaagta atttccaatt gatagctggc aaagggatgc
     6301 ccctcttgat tttgtagttg ataagctagc tcaatctttt gcctatcaac ttgataacgg
     6361 ctcgtttgaa tgataaattc ctgcatgccc ataggggtag gaatataggc caaactatca
     6421 ctatccttta aaaagcgcat aatggtcttg ggattagaaa atcggctcat caccagttct
     6481 tgaccatgaa atttaatcac tactttttcc ttttcctcat tatagaaaag caggtagcta
     6541 taatctcctt tttcatgcac ttccacatca taaagccggt caatcacttc caactgctca
     6601 tcaaactgaa ttgtatttcg catccgaatc ttcacatcag gccctctttc ttgtctcttg
     6661 tcctactatt ttaccaaaaa gagcaggatt ttgctataat ggtcatatga acgaaaaagt
     6721 attccgtgac ccagttcaca actacatcca tgtcaataat caaatcatct atgacttgat
     6781 taatacaaaa gaatttcagc gtttgcgccg tatcaagcaa ctgggaacct ccagttatac
     6841 cttccacggt ggagagcaca gccgcttctc tcactgtcta ggagtctatg agattgcacg
     6901 acgtatcaca gaaatttttg aagaaaaata tcctgaggaa tggaatcctg ccgagtctct
     6961 cttgaccatg accgctgctc tcctacatga ccttgggcat ggcgcctact cccatacttt
     7021 tgaacatctc tttgatacag accatgaagc cattactcag gagattattc aaaatcctga
     7081 gacagagatt caccaagtct tgctacaagt agcgcccgat tttccagaaa aagttgccag
     7141 tgtcatagac catacctatc ctaataagca ggtcgtgcag ctcatttcta gtcagattga
     7201 cgcagatcgc atggactatc tcttgcgcga ctcctatttt acaggagcat cctatgggga
     7261 atttgacctg actcgcatcc tccgagtcat tcgtcctgtc gaaaatggta tcgcctttca
     7321 gcgcaatggc atgcacgcca tcgaagacta cgtcctcagt cgctaccaga tgtacatgca
     7381 ggtttatttc cacccagcaa cacgcgccat ggaagttctc ctacagaatc ttctcaagcg
     7441 cgccaaggaa ctctaccctg aggacaagaa tttctttgca cgaacttccc cacatctcct
     7501 gcctttcttc gaaaaaaatg tgaccttgac tgactatctg gctctggatg atggcgtgat
     7561 gaatacctac ttccagcttt ggatgactag tcctgacaaa attcttgcag atttatctca
     7621 acgctttgtc aaccgcaagg tctttaaatc cattaccttt tcacaagagg accaagatca
     7681 acttactagc atgagaaaat tggttgagga catcggcttt gatcccgact actatactgc
     7741 cattcataag aactttgacc tcccttatga tatctatcgt cccgaatctc aaaatccacg
     7801 gacacagatt gagattttac aaaaaaatgg agaactggcc gaactctcta gcctgtctcc
     7861 tatcgtccaa tcccttgctg gcagtcgcca cggagataat cgcttttatt ttccaaaaga
     7921 aatgttggac caaaacagca tctttgcaag cattacccag caatttttac acttgattga
     7981 gaacgatcat tttaccccaa ataaaaacta gaagaggaat tttatgagta ttaaactaat
     8041 cgctgtcgat attgacggaa ccctagtcaa cagtcaaaag gagattactc ctgaagtctt
     8101 ttctgccatc caagatgcca aagaagctgg tgtcaaagtc gtgattgcaa ctggccgccc
     8161 catcgcaggt gttgccaaac ttctggacga cttgcagttg agagaccaag gtgactatgt
     8221 ggtgaccttc aatggtgccc ttgtccaaga aactgctact ggccatgaga ttatcagcga
     8281 atccttgacc tatgaggatt atctggatat ggaattcctc agtcgcaagc tcggtgtcca
     8341 catgcatgcc attaccaagg acggtatcta tactgcaaat cgcaatatcg gaacatacac
     8401 tgtacacgaa tcaaccctcg tcagcatgcc tatcttctac cgtacccctg aagaaatggc
     8461 tggcaaagaa attgttaaat gtatgtttat cgatgaacca gaaattctcg atgctgcgat
     8521 tgaaaaaatt ccagcagaat tttacgagcg ctactccatc aacaaatctg ctcctttcta
     8581 cctcgaactc cttacaaaga atgtagacaa gggttcagcc attactcact tggctgaaaa
     8641 actcggattg accaaagatg aaaccatggc aatcggtgac gaagaaaatg accgtgccat
     8701 gctggaagtc gttggaaacc ccgttgtcat ggaaaatgga aatccagaaa tcaaaaaaat
     8761 cgccaaatac atcactaaaa caaatgacga atccggcgtt gcccacgcca tccgaacatg
     8821 ggtactgtaa aaggaaagaa tagactaaaa ccgctcagct gagcggtttt tgatatctaa
     8881 ttacatgccc cctgcaggaa tcgaacctgc aactactcct taggagggag ttgttatatc
     8941 cattgaacta agggagctag ataaaaactc tgctgaaaaa gcagagtttt ttagtcgaat
     9001 taacgacgga tttctttgat acgagctgcc ttaccttgaa gagcacgcaa gtagtacaat
     9061 ttcgcacgac gtactttacc gtaacgtaca acttcgattt tttcaacacg tggagtgtgg
     9121 attgggaaga tacgctcaac acctacaccg ttagagattt tacgaactgt gtagttttca
     9181 gagatgccag cacctttacg tgcaataaca acaccttcaa aaatctggat acgttcacgg
     9241 ttaccttcga caactttcgc atgtacacga acagtgtcac caggacggaa tgatgggata
     9301 tctgtacgaa gttgaccttc agtcaagctt tggattaatg gattcatttt attctcctat
     9361 ctttgtcaat cttgaggaat cttcctcagc ggataaactg tatttttgtg cgtccattac
     9421 acacaagata tagtttacca aatttctaaa aaaaagtaaa gaaatttata gcaaaattcc
     9481 taaaaaaatc gcaaccaaac cacctatgta agtcaaagtc aggtaagaat aaaagacctt
     9541 cttatcactt agcagtcttt gaagttcgtc attcaaggtc gaaaaagttg ttaaaccgcc
     9601 acaaaatcct gttgctagaa tagcatatac ttccttagac tctacatgat tgtaaaatac
     9661 tccaattaaa aaacaaccta aaagattagc tatgagcgtt ccgagtggca atttagaagc
     9721 ttgattatag cgagaaaata aatagcgcac taaagctccg aaaccacaag caattgcaag
     9781 atagacgatt accatttctt cctccctaga aaataagcta agagtaggcc tccaccgatg
     9841 ctcaaaagca aatacaggac taaactaaaa taacgccctg tatcaagcag cttcacagta
     9901 tcaagcatta ggctggaaaa agttgttaaa cctccgcaaa aacccgtccc cagtgctaaa
     9961 atcaagccct tactagtccc cttatagacc agatagccct tgaaaagaaa aatcaagcag
    10021 aaaattccca gatagttgac aaagagagtg ccccaaggaa agtctggact ggctggtaac
    10081 caggtggaaa ctagatatcg gacaagtccg cccaacatag cagctagaaa aattcctagc
    10141 ggataaaatt gttctttttt catttgatat tttgatcctg ataatcacgc gaacgtttga
    10201 gtatgtccga aaaagtcgct acaatagtct cctgatagcg cttgtcctct acacgactcc
    10261 caaccttttc aaaaataact tcttctctct tagtatctaa aatcggttta cctgaagctt
    10321 tcttataagc aaccaccccc tcaactaaat gcattcgttc ttctaacagt ttgacaattt
    10381 ggtcgtcgat ttgatcgatt tcttgacgaa taatatctaa atccatacag tctcctcctt
    10441 tatttgaatt attgtatcaa aaagccatca attaggctag taaaatccca actctcgata
    10501 agaaaaatgc actgattgat tacatcagcg cacttttatg cttatcctac tttagcaacc
    10561 aattcttctg cgaattgttc caagcgttca atatcttctt cctcggcaga aagatcaact
    10621 ttgacacact cagaaccttt ttctgctcct gttgaaacaa agacacggtc aaagtcatca
    10681 acagccttac agaattcatc gtagaaggta tctcctgagc cgaccactcc gtagattttg
    10741 ccattcaagt tgagatctgc tagatcttcg tagaagtcca tcatctcatc tggcaattca
    10801 ccatcaccat aagtataggt cgcaacgata gcgatgtctg cttccaagaa gtctgaagcg
    10861 tcaacagttg tacattcatc aacatcaaca tccaagccca agtcacgtaa tttgtctgct
    10921 acaatatctg caatttcttc ggtattaccg gtcatactgg caaatacaat ttttgctaat
    10981 gccatatcgt cctcctcaat ttatctttct ccattatatc acatcttttt cattttaaaa
    11041 ataaaaattc ttgtgctaca atgaaatgag aaagaattga ggttatttat ggagatttgc
    11101 caacaaattt tagaaaaaat taaagaatac gacaccatta tcattcatcg tcatatgaaa
    11161 ccagaccctg atgccttggg aagtcaggtg ggattgaaag ccttgctgga acatcatttc
    11221 ccagaaaaaa ccatcaaagc cgtcggtttt gatgaaccaa ctcttacttg gatggctgag
    11281 atggatcttg ttgaagatag agcctaccaa ggcgcacttg tcatcgtctg tgatacagct
    11341 aatactgctc gtatcgatga taagcgctat agtcaaggtg attttctcat taagattgac
    11401 caccatccaa atgatgatgt atacggtgac ctgtcttggg tcgatactag ttcaagtagc
    11461 gctagcgaga tgattaccct atttgcccaa acaacccaac tagccttggc agatcgcgat
    11521 gctgagttgc tctttgcagg aattgtcggt gatacaggtc gcttcctcta cccttctacc
    11581 actgcacgga ctcttcgcct ggctgcttat ttgagagaac ataactttga ctttgcggct
    11641 ctcactcgca aaatggacac tatgagctac aaaattgcta aactgcaagg ctacatctac
    11701 gaccatctgg aagtggatga aaatggtgct gctcgcgtta tcctgagtca agaagtcttg
    11761 aaacaataca atgtaaccga tgctgaaact gcagccattg tcggtgcacc tggacgcatt
    11821 gacagagtga gtctctgggg aatttttgtc gaacaggctg atggccacta ccgagttcgc
    11881 ttacgcagta aaatccatcc tatcaatgaa attgccaagg agcatgatgg tggaggccac
    11941 cctctagcaa gtggtgctaa ttcctatagc ctagaagaaa acgaaatcat ctaccaaaag
    12001 ttaaaaaact tgcttaaaaa ctgataaaat acttgccaaa cttttcagaa tctgatagac
    12061 tagtatggta acaatctatg gctcgcaaag agaccatggc agaaaggaaa tattgcaaaa
    12121 tgaaaaaaga tatccatcca gaatatcgcc cagttgtctt catggacaca actactggtt
    12181 accaattcct tagcggttca acaaaacgct ctaacgaaac agttgagttc gaaggcgaaa
    12241 cttacccatt gatccgtgtg gaaatttcat cagactcaca cccattctac actggacgtc
    12301 aaaagttcac tcaagcagat ggacgcgtgg atcgtttcaa caaaaaatac ggtctcaaat
    12361 aatgataaaa gaacagtttc gactgttctt ttttgtttct tgaaatcaac tgctgttttc
    12421 atgttccaga ctcatctgta ggttcggttt ccatgctact aggcaggaag gaaatagctg
    12481 tttcaacacg tccataatga gctgtgctat tgtcacgaac cacactttca ttgatggtcc
    12541 aagtggaatt cattttctta aaagcttctc ggactttttc caaatctttg gaggcaatgg
    12601 cctgctctaa ggtttcaaaa cgaggactta tactcatctg ctttcacaaa gcattctagt
    12661 ccatctccga ttaacgatgg actttatcac ctccttctcc agtccttgta tgacatcttg
    12721 aagttgattc atgatatctt ccaaagttcg aaaggcttta ttcttaaatc cacgtttacg
    12781 aatctctttc cacacttgtt caatggggtt catctctggt gtgtatggag gaataaatgc
    12841 aaaaccaata ttagtcggaa tctttaaggt acttgattta tgccatatag cattgtccat
    12901 aacgaataaa agataatcat ctggataagc ttgtgaaagc tcttctaaaa aggcgttcat
    12961 ccactcagta ttacatctac cagctattaa gaaaaatgat tcgcctgtat gggcatcaac
    13021 agctccataa caatagcgaa attctcgtat atagtgacta tggacatgtg gacctactcc
    13081 tattggagac caacaagatc ccagtttact gattctaccg aaaccagcct catcttggta
    13141 catcaagcga accttatgaa aacgtctact ggttttaaag cgctttcttg tcttcttgaa
    13201 ttgagatttt atttttagac gcgacaatgg tttgagcgtc tgctttctta ggatgttctg
    13261 gacgtggcat aatatttcgc caaccatggc gcttcaacag ttgatagaag gcatcacgtg
    13321 tgtaggaacg atataagcct gaaataaggt attgtaacaa attctcctgc ctctgtagcc
    13381 ttcaaatggc gggcaagaaa ggctttctct tcctcaactg tcatatatgc atggtt
//
LOCUS       DAVHSO010000059        13333 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.060, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000059 DAVHSO010000000
VERSION     DAVHSO010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13333)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13333)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13333
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.060"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..326
                     /locus_tag="VVR18_001775"
     CDS             <1..326
                     /locus_tag="VVR18_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019213953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="nickase"
                     /protein_id="HEU6033255.1"
                     /translation="KKLLSDKEKLSPKKWNEEKILLMSNLEEINKEKDKIKDEYQEIN
                     HIKYSVDFVNKELGIDLSIEIDKLIKQGEKPSVIAQIKKFQDQVNKDNEYREMMKNKK
                     MDQER"
     gene            400..573
                     /locus_tag="VVR18_001776"
     CDS             400..573
                     /locus_tag="VVR18_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019118552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033256.1"
                     /translation="MNKRQELIDELIKANEDGTYKTYKSTEEIKAMNNEEIQIIYSNI
                     KNYLSDKRTHINY"
     gene            759..1295
                     /locus_tag="VVR18_001777"
     CDS             759..1295
                     /locus_tag="VVR18_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008902124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PcfB family protein"
                     /protein_id="HEU6033257.1"
                     /translation="MINEEISKEAGQAAQTAQTIISYTIKETKESINLEKEIRKKMNE
                     TLEKANGNLKSLMGDEMKIKDLYKKGQLENISIDQIDLKDLKKELNKLGVSFSVMKNK
                     ESKNYEIFFQAKDIKVMEYAFKQVISKENKKEKESILKQIKKYKDLSKNKDKTKEKGK
                     RKVKEKVKPNKKDMTREI"
     gene            1422..2142
                     /locus_tag="VVR18_001778"
                     /pseudo
     CDS             1422..2142
                     /locus_tag="VVR18_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000224688.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
     gene            2826..2987
                     /locus_tag="VVR18_001779"
     CDS             2826..2987
                     /locus_tag="VVR18_001779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033258.1"
                     /translation="MDNDWNGLADLIANLIAKYAGALDLDNLPDQTPAKNQEMKNSFD
                     MAKTQIETD"
     gene            3079..4758
                     /locus_tag="VVR18_001780"
                     /pseudo
     CDS             3079..4758
                     /locus_tag="VVR18_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031864.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
     gene            5026..5592
                     /locus_tag="VVR18_001781"
     CDS             5026..5592
                     /locus_tag="VVR18_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033259.1"
                     /translation="MVILELYQNDYSKDLVAFDSIEDGKAFVAQIPGYTLETEDGFEV
                     EYFNPKNIPDYMEIIFNGNIVPLSKFMFDPEENVNIIWKEISNLSLKNDRVIEGYSKI
                     DAYVVNNHEVKAYVETRETNYRKAKDFLESNGYEIDRSFFGSEDGEAILYRKKGIEVW
                     HFLCHVDPMFVEIEDVEGYVKEEVGEIQ"
     gene            5914..6102
                     /locus_tag="VVR18_001782"
     CDS             5914..6102
                     /locus_tag="VVR18_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HEU6033260.1"
                     /translation="MATDKNRIMISLDDKNLEKLENLVEDARDRRGMRLTKSQVIELL
                     LNTVDYFDDIMGAIYSKK"
     gene            6164..6922
                     /locus_tag="VVR18_001783"
     CDS             6164..6922
                     /locus_tag="VVR18_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEU6033261.1"
                     /translation="MVVYIRQSKLLSEVSINKYNAQVGAYLQGEEVILYQSFSKIKEL
                     TSEDIDVDYIMETRALLKMMGLNVPVYDYPIELKEFYGRKIYAGILGEIVNIPDNWGK
                     FIKPKAGSKVFTGRVVNGTHDLIGIGLPFDYPIWISEVVEFIAEWRCFVLDGRVLDVR
                     PYTGDYHAQFDASVIDEAISCWKDAPIAYGLDIGVTRDGRTLVVEVNDGYALGNYGLS
                     PLKSINFHRARWKEMVKPYFEKNEIFKIQQDVIF"
     gene            6980..7834
                     /locus_tag="VVR18_001784"
     CDS             6980..7834
                     /locus_tag="VVR18_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="HEU6033262.1"
                     /translation="MLGAIIGDIVGSVYEWNNIKTKDFPLFRKDCFFTDDTVMTCAVA
                     EAIMNGGQKDDFIDAMKKYGRMYPNADYGARFNAWLNSDNREPYNSFGNGSAMRISPC
                     AWIMDCGFYAKTGIWPSSRGLTSLSAEVTHNHPEGVKGAMATADAIFLCRFYFGGYCR
                     EYEQSINDNPTECKRRIKDYIEKEYDYNLSQTLDEIRPNYRFNETCQETVPQAIIAFL
                     ESRDFEDAIRNAISLGGDSDTLAAITCSIAEAAYGIPDWIKDKAYSYLDEPLKDVVRR
                     WENRIKAY"
     gene            7946..8830
                     /locus_tag="VVR18_001785"
     CDS             7946..8830
                     /locus_tag="VVR18_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
                     /protein_id="HEU6033263.1"
                     /translation="MKKAMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKAL
                     DATHFAEEASRERYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKFLE
                     INQDIDDAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEIEDKTKFGILT
                     YAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNYFADKKIFEENKDGYANIL
                     ILKDASIFSKLSVIPDLLKGDVVANDNIEYIKARNIKISSDSELESDVDGDKSDNLPV
                     EIKVLAQRVEVFSKPKED"
     gene            8993..10732
                     /locus_tag="VVR18_001786"
     CDS             8993..10732
                     /locus_tag="VVR18_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
                     /protein_id="HEU6033264.1"
                     /translation="MELSAIYHRPESEYAYLYKDKKLHIRIRTKKGDIESINLHYGDP
                     FIFMEEFYQDTKEMVKITSGTLFDHWQVEVSVDFAHIQYLFEIIDTEGQNILYGDKGC
                     VENSLENLHAIGNGFKLPYLHEIDACKVPDWVSNTVWYQIFPERFANGNALLNPEGTL
                     DWDSSVTPKSDDFFGGDLQGIIDHMDYLQDLGITGLYLCPIFESTSNHKYNTTDYFEI
                     DRHFGDKETFRELVDQAHHRGMKVMLDAVFNHIGSQSLQWKNVVKNGEQSAYKDWFHI
                     QQFPVTTEKLVNKRDLPYHVFGFEDYMPKLNTANPEVKNYLLKVATYWIEEFNIDAWR
                     LDVANEIDHQFWKDFRKAVLAKNPDLYILGEVWHTSQPWLNGDEFHAIMNYPLSDSIK
                     DYFLRGIKKTDQFIDEINGESMYYKQQISEVMFNLLDSHDTERILWTANEDVQLVKSA
                     LAFLFLQKGTPCIYYGTELALTGGPDPDCRRCMPWERVSSDNDMLNFMKRLIKIRKYA
                     SVIISHGKYSLQEIKSDLVALEWKYEGRILKAIFNQSTEDYLLEKEAVALASNCQELE
                     NQLVISPDGFVIF"
     gene            11007..11462
                     /locus_tag="VVR18_001787"
     CDS             11007..11462
                     /locus_tag="VVR18_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033265.1"
                     /translation="MGAARDFLELINHKGLPLFNPLVGDSHVNNRQEYDNTGSGNLQP
                     EKWNETAKQLYNAIMWLIILWNAKPDTPLFNFKDEVIKYKTYEPFESSIKRVNTTIKN
                     GSKGKTLTEMINGYRADNDIRDEICNFNILKNKIRDMKNQQGNTMESYF"
     gene            11907..12383
                     /locus_tag="VVR18_001788"
     CDS             11907..12383
                     /locus_tag="VVR18_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033266.1"
                     /translation="MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTE
                     LIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGI
                     SIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA"
     gene            12383..13144
                     /locus_tag="VVR18_001789"
     CDS             12383..13144
                     /locus_tag="VVR18_001789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="HEU6033267.1"
                     /translation="MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAG
                     KTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQEYGKDSVEYTKDFAGKMVESLV
                     TKLSSLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKSELSYLSTLIRYEE
                     LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTT
                     SAAEVLQEYLFGKWSKVEEEMLKVGEKRLNELLEK"
BASE COUNT         5079 a         1830 c         2669 g         3755 t
ORIGIN      
        1 taaaaaaact cctatcagat aaggaaaaac taagtcctaa aaagtggaat gaagaaaaaa
       61 ttcttttaat gtcaaatctt gaagaaataa ataaagaaaa agacaagata aaagatgaat
      121 accaggaaat taatcatata aaatattcag tagattttgt aaacaaagaa cttggtatag
      181 atttatccat agaaatagat aagctaataa aacagggaga aaaaccaagt gtaatagcac
      241 agattaaaaa gttccaagac caagtcaata aagataatga atacagagaa atgatgaaaa
      301 acaagaaaat ggatcaagaa agataagacc tggtaaaaat atcttatcca agctataata
      361 tgaccaaaca actaaagtca gatctaggag gtaatagaga tgaataaaag gcaagagcta
      421 atagatgaac tcataaaagc aaatgaagat ggaacataca aaacctataa aagcacagaa
      481 gaaataaaag caatgaacaa tgaagaaata cagattatat attccaacat aaaaaactat
      541 ctatcagaca aaagaacaca cataaactat taaaggtgga aaggtagtgt aagctatttt
      601 taaaagtata aaaggtacaa agacctaaga aatatataaa aacatcaaaa taaagtattc
      661 caccaccaag aacaataaaa taaaaacaag caaagggaag tatagaaaaa ttaaaaccta
      721 tacttccctt ttttaattca aacaaaggag agaaaagcat gataaacgaa gaaataagca
      781 aggaagcagg tcaagcagca caaacagcac aaaccataat atcatacaca ataaaggaaa
      841 caaaagaatc aatcaattta gaaaaagaaa taagaaaaaa gatgaatgaa actttagaaa
      901 aagcaaatgg aaacttaaaa agtcttatgg gcgatgaaat gaaaataaaa gacctctaca
      961 agaaaggaca actagaaaat ataagcatag atcaaatcga cctcaaagac ttaaaaaaag
     1021 aactaaacaa acttggagta agtttctcag taatgaaaaa caaagaaagc aaaaactatg
     1081 aaatattctt ccaagccaaa gacataaaag taatggaata tgcctttaag caagtcatat
     1141 ccaaggaaaa taaaaaagaa aaagaaagta tcctaaaaca aataaagaaa tacaaagacc
     1201 tatccaaaaa caaagataag acaaaagaaa aaggaaaaag gaaagtaaaa gaaaaagtaa
     1261 aaccaaacaa aaaagatatg accagagaaa tctaaaggga gtaacgaaaa gttacaccct
     1321 taaataacca taataacaag acttccgaaa aacagaagtc cagaattccg aaaatcggaa
     1381 atcaagaatt tcgattatcg aaaatcaaga aaggagcaga tatggcaaca aacaaaagat
     1441 actattggat aaaattaaaa gaagaatttt tcacagacaa aaggataaaa aggttaagga
     1501 gaatatctgg aggagatacc tatacgataa tctacctaaa acttctacta ctaagcctaa
     1561 aagatgaggg caaactctat tatgacggag tagaaagtga ttttataaaa gagttagcac
     1621 taaccataga tgaaacagac gatgatgtaa tggtaacagt aaattattta atcaatcaag
     1681 gcttattaga agttgtaaca gaaaatgatg aatactacct aactgaaata ccaaacttaa
     1741 tcggatcaga aacagcctgg gcagagaaaa aaagaagata cagacaaaat aaacagagga
     1801 cattgtcctt aatgagtcca acccatgtcc gacaagagat agagaaagat atagagatag
     1861 ataaagagag agggagagat agataaaaag tccaccccca ttttttatgg agaattcaaa
     1921 aatgtaaggt taagcaaaga agaatataaa aatctaaaag aaaaattaaa ctcacacaca
     1981 gatataatga taaataaact atccagatac atggaaagca gtggtaagac ctatcaaaat
     2041 cactatgtga caatcttaaa atggtatgaa gaagataaag acaaactaag acagaaaggt
     2101 ttaaataaaa aaatgaatta tgatgtagga gaatctttat agataaaaag aggtggaaag
     2161 gcactattaa agactttaag tctaaaaagg tatcaaagta tgccagagat aaaaaaatat
     2221 aaatatgaca ctttaaaggc gattagaaaa ttaaagaaat gctagaagac ttttagatga
     2281 cagttaccaa gagggtctaa ttttcactgc tacttatgca gtgggaattg gaccttttta
     2341 tataagcaaa ttctatttca aaattggtta ccaagaaaga cttcttttca ctgttaagta
     2401 taagagggta atttatagaa ttttgttaca tcaagataaa tattttctga tggtcaaatt
     2461 ttaaaaagat taataactct cgataaattt tgaaccttaa caattgaata gaccaagaca
     2521 agacgttaat tatttttgga gcgtaataac ctatccgtca agatctttcg gctgaataat
     2581 tcggcaaaaa aagttctgct aagcaaaaag aaagtgagcg ataagtaaga gtttgaatat
     2641 aggaagggat accctatccg ctatgaagaa aatgaggata atgatacttc taaggttgaa
     2701 gccggctcat ccggaataga ggcggaggtg agattcctat gttgctaatc caaagcactt
     2761 gtcaatgtca aaaaacttaa ttaaacaaat aattattaga tataaaactt tagaggaggt
     2821 atatattgga caatgactgg aatggattgg ctgatttaat agcaaatctg attgcaaaat
     2881 atgctggtgc tttagattta gataatctac ccgatcaaac gccagcaaaa aatcaagaga
     2941 tgaaaaatag ttttgacatg gcaaaaacac aaattgagac ggactaataa aagtgttata
     3001 atatacttga aatgatagtc caaacttaaa ttaaaaaaat tatatatgat atagaaaaat
     3061 tatattgagg ttaatactat gtcaaaagaa aaaataaaag tatacctcta tacacgagta
     3121 tctacgtcaa tacagataga ggggtattcg ttagaggcac aaaaatcacg aatgaaagct
     3181 tttgctattt acaacgatta tgaaattgtt ggagagtatg aagatgccgg gaagtctggc
     3241 aagtctattg aaggtagaat acagttcaat cgaatgatgg aagatataaa atctggaaaa
     3301 gatggagtat cttttgttct tgtgtttaag ttatcaagat ttgcaagaaa tgccgctgat
     3361 gttctttcta cacttcagat aatgcaggat tatggagtta atcttatctg cgttgaagat
     3421 ggcattgatt catctaaaga tgctgggaaa ctaatgattt ctgttttatc agctgtggct
     3481 gaaatagaaa gagaaaacat ccgtattcaa acaatggaag gtcgcattca aaaagcaagg
     3541 gaaggaaaat ggaatggtgg ctttgctccg tatggatata aacttgaaga cggcaagctg
     3601 tttataaatg aggaagaggc agttgcaata agaacgattt tcgaccagta tgtaaatact
     3661 acgataggag ccaatgggat atctaaatac ttagagaatc atggaattag aaaaatccca
     3721 agacagaatg gtaagaatcc tttgtttgat gcaggtctta taagaaagat attaaagaat
     3781 cctgtatata atgggaaaat agcatttgga agaagaactt tagaaaaagt tcatggtaca
     3841 agaaatgaat ataagcaggt tgaacaagat gaatatctaa tatctgaagg gatacatgaa
     3901 gctatagttt ccgatgaagt ttggcaagct gctcaggtta agctaaaatc tcaagcaaag
     3961 aaatatgagc atgtgaataa aggaaaagat acacgcacac acttgctttc tggaattgta
     4021 aaatgcccga tatgtggagt gggaatgttt gggaacaagt gtatcaagaa aaagaaagat
     4081 ggcacaaagt ataaagattt ttattactat ggttgtaaac ataggcagat gataagaggt
     4141 cataagtgta cattcagtaa gcaaattaga gaagaattgt tagatgatgc tgttgcagag
     4201 gtgattgtca agatagtaag taatccgaaa tttgcttcta tgatgcaaga aaaaatcaac
     4261 atgaaggtgg atacctctga aatagaaaaa gaaatagata attaccaaaa ggaattgaga
     4321 aagagtcatt ctacaaagtt taagctaatt gaggaaatag ataatttaga tgttgaagat
     4381 aagcattata agagaaggaa acaggattta gatgatagac tatatcgtat gtatgacaaa
     4441 atagatgaat tagaatcatc actaattgat gcgaaagcaa agaaacagac tattgaagct
     4501 gaaaagctta caggagataa catatataag gttctgatct attttgataa gctctataaa
     4561 gtcatgaatg atgtagagcg taggtagtta atttcagctt tgatttctga aattcaagtt
     4621 tatgaagaaa aacaatctaa cggataatgg ctaaaatcca ttacttttaa gctaccaatt
     4681 atagaagaaa atctcaacat aggtttggac aatgatgaac aagttgaatg tgtaagttta
     4741 ttagagaaac gtagttaatc ctcaaaaggt tccccaaacc ttttgagtcc cactgacgca
     4801 tcacgctgag gcggtatcac tgcttgtacg agttgaagca tcagcgaagt aaaagtagat
     4861 gttcagccaa tgcgacgagg tgagaccgaa ggtcgataag gtgtgttctg ggtataggac
     4921 tcgtaaagta agtaggaaat atgatgagat gatacagaga gcctgaattg gtcaggtgac
     4981 gtgcttattt acattagcct gataatgaaa atggagagat tatcgatggt tatattggaa
     5041 ttgtaccaaa atgattattc taaagattta gtagcatttg attccataga agatgggaaa
     5101 gcctttgtag ctcaaatccc gggatacact ctggaaacag aagatggttt tgaagtggag
     5161 tattttaatc ctaaaaacat accggattat atggaaatta tttttaacgg aaatattgtt
     5221 cctttatcta aatttatgtt cgatcctgag gaaaatgtaa acattatttg gaaagagatt
     5281 tcaaatttat ccctcaaaaa tgatagagtg atcgaaggat attcaaaaat tgatgcatat
     5341 gtcgttaaca accatgaagt taaagcctat gtcgaaacaa gagaaacgaa ctatcgtaaa
     5401 gcaaaagact tcttagaaag caacggatat gaaatcgaca gaagcttttt cggaagtgaa
     5461 gacggtgaag cgattcttta cagaaaaaaa gggatcgaag tttggcattt cttgtgtcac
     5521 gtagacccaa tgtttgtaga gattgaagat gtagaaggat atgttaaaga agaagttgga
     5581 gagattcaat agtcaaccaa agttccttgt gagtatatac ctttgctagt aaaagagtca
     5641 aaacgttata acgaaggggg ggaagaaaac ccttgagtgt aagtcttttt cttgtttaga
     5701 gggaaagtat tagagtagcc gctcataatt tatactagat ttgataactg atttgagaca
     5761 gattttattt ctataaatat tgtgaaaatt ttttaatacc aaagatttaa agttactgtg
     5821 ttaaaaatcc tctccacttt taaactaatg tattataaaa gccagttgac acaagtgtta
     5881 cacctgtgat agaattaact tgaggtgatg aaaatggcaa ccgataaaaa tagaataatg
     5941 attagcttgg atgataaaaa tctagagaaa cttgaaaatt tagtagaaga tgctagagat
     6001 agaaggggaa tgcgactaac aaagtcccag gttattgaat tactcctaaa taccgttgat
     6061 tatttcgatg atattatggg ggctatttac tcaaaaaaat aagagcaaaa ttgctattat
     6121 tttttacaaa ttggtgtaac actagtgata taggagtgat gaaatggttg tttatattag
     6181 acaaagtaaa ttactaagtg aggtttcaat taataaatac aatgctcaag taggtgccta
     6241 cttacaagga gaagaagtta ttttatatca atctttttct aaaataaaag agttaacaag
     6301 tgaagatata gatgtagatt atataatgga gactagagca ttactaaaaa tgatgggctt
     6361 aaacgttccg gtttatgact atcctattga gcttaaagag ttttatggtc gaaagattta
     6421 tgctggtatt ttaggagaga ttgtgaatat acctgataat tggggaaaat ttattaagcc
     6481 taaagctggt tcaaaagtct ttactggaag agttgttaat ggaacccatg atttaatagg
     6541 tattggtcta cctttcgact atcctatatg gattagtgag gttgtagaat tcatagctga
     6601 atggcgttgt tttgtgttag atggtcgcgt attagatgtt cgaccctata caggtgatta
     6661 tcatgcacaa tttgatgcaa gtgtaattga tgaagcgata tcatgttgga aagatgcgcc
     6721 aatagcttat ggactagata tcggtgttac tcgcgatggc agaacacttg ttgttgaagt
     6781 aaatgatggt tatgcattgg gaaattatgg cctatctcct ttaaaatcaa tcaattttca
     6841 tagagctagg tggaaagaaa tggtaaaacc ctattttgaa aaaaatgaaa tttttaaaat
     6901 ccaacaggat gttattttct aaaataaata tggtagataa ccaatataaa aagcatcaaa
     6961 atgaacaagg aggaatctga tgcttggagc aattattgga gatattgtcg gttctgttta
     7021 cgaatggaac aatatcaaaa caaaggactt tcctttattt cggaaggact gcttttttac
     7081 agatgacacg gttatgacct gtgctgttgc agaagcaatt atgaatggtg gacaaaaaga
     7141 cgacttcatt gacgcgatga agaaatatgg cagaatgtat ccgaatgctg attacggtgc
     7201 tcggtttaat gcgtggctaa acagcgataa ccgtgagcct tataatagct ttgggaatgg
     7261 atcagctatg cgtatttctc catgtgcttg gatcatggac tgtggttttt atgcgaaaac
     7321 tggtatatgg ccatcatcta gaggacttac gagtctttct gcagaggtaa ctcataatca
     7381 tccagaaggt gtcaaaggcg ctatggctac agctgatgct atctttctat gtcgttttta
     7441 ctttggtggt tattgtagag agtacgagca atcaattaac gacaatccta cagagtgtaa
     7501 aagacgaatt aaggattata tagaaaaaga atacgattac aatctatctc aaactttaga
     7561 tgaaatccgt cctaactatc gttttaacga aacatgtcag gaaactgtcc ctcaagccat
     7621 tatcgccttt cttgaaagta gagacttcga agatgcgata agaaatgcca tctcacttgg
     7681 tggcgacagt gatactctcg cagcaatcac ttgtagcata gcagaggcag cttacggtat
     7741 tcctgattgg atcaaggata aggcctattc ttacttggat gaacccttaa aggatgtagt
     7801 taggcgatgg gaaaatagaa taaaagcgta ttaatctcca gtacgtcaga tttctctttt
     7861 ctgtattttc attgtataat aggattacat ttacttgcat acgacgaaat gtaaacattt
     7921 ctatttaaaa ttaaggataa aatcaatgaa aaaagcaatg gtaattatca accctacttc
     7981 tggtggcgag aaggctttgg attacaaaga aaagctggag aataaagcaa aagaatactt
     8041 tgaatatgtt gaaaccaaaa ttaccgaaaa agcgctggat gcaacacatt ttgctgaaga
     8101 agcttctcgt gagcggtatg atgcagtggt tgtgtttggt ggagatggaa ctgtcaatga
     8161 agtcatttca ggtattgatg agagagacta cattcctaag ttagggatta tcccaggcgg
     8221 tacgggtaac ctcattacaa aatttttgga aatcaatcaa gacatcgatg acgcaattga
     8281 cgaactggat tttgatttaa ccaataagat tgatatcggt aaagcaaatg acaactattt
     8341 tggttatatc tttagtatcg gttctctgcc tgaggcgatt cacaatgttg aaatagagga
     8401 caaaacaaaa ttcggtattt taacctatgc tgtaaatacc atgaagtctg tcatgacaga
     8461 tcaggtcttt aacattaagg ttgagacaga aaatggaaat tatgttggtg aagctagcca
     8521 tgttttggtt cttttgacaa attacttcgc tgataagaaa atctttgaag aaaacaagga
     8581 cggctatgcc aacattttga ttctgaaaga tgcctctata ttctccaaat tatccgtcat
     8641 tcctgattta ttaaaagggg atgttgtcgc aaatgataat atcgagtata tcaaagcgcg
     8701 taatattaaa atctcttcag atagtgaatt ggagtcagat gttgacggag ataaatcaga
     8761 taacctacct gtagaaatca aagtcctagc tcagcgagta gaagtatttt caaaaccgaa
     8821 agaggattag tatatagaga aagccttttt taaggctttt tgtatacttt aaaagatagt
     8881 tcctttaaca acggacattc cttgcaaata gtttacaaaa atagtatact ggatttattg
     8941 agtttgaaaa cgtttgcgta aaatttgaat gaatacttta ggagacaaat tgatggaatt
     9001 gagtgctatt taccataggc ctgagtcgga gtatgcctat ctttataagg ataagaaact
     9061 ccatattcga attcgaacta agaaagggga cattgaaagc atcaacttgc actatgggga
     9121 cccttttatc tttatggagg agttttatca ggatacaaaa gaaatggtca agataacttc
     9181 tggtacctta tttgaccatt ggcaggttga agtgtcagtt gactttgcac atatccagta
     9241 tctctttgag atcatagata cagaaggtca aaatattttg tatggcgata aagggtgtgt
     9301 ggaaaattct ctagaaaatc ttcatgcaat tgggaatgga tttaagttgc cttatcttca
     9361 tgagattgat gcctgcaagg ttcctgactg ggtttcaaat acggtatggt atcagatatt
     9421 tcctgaaaga tttgccaatg gcaatgctct attaaaccca gaagggactt tagactggga
     9481 ttcatctgtc acacctaaga gcgatgattt ctttggtggt gatttacagg ggattattga
     9541 tcatatggat tacttgcaag acttgggtat tactggacta tatctttgtc ccatctttga
     9601 atctacaagc aatcacaagt acaatacgac agattacttt gaaattgacc gtcattttgg
     9661 agacaaggag acctttcggg aactggtgga tcaagcgcat catcgtggca tgaaagtcat
     9721 gctggatgcg gtatttaatc atattggttc gcaatctctt caatggaaaa atgtcgtcaa
     9781 aaatggtgaa cagtctgctt ataaggattg gttccatatt caacaattcc cagtgacaac
     9841 tgaaaagcta gttaataaga gagacttacc ctatcatgtt tttggtttcg aggactatat
     9901 gcctaagcta aatacagcca atccagaggt caagaattat cttttaaagg ttgcgactta
     9961 ttggattgaa gagtttaata tcgatgcttg gcgtttggat gtggctaatg agattgacca
    10021 tcagttctgg aaggattttc gtaaggcagt tttagctaaa aatcctgatc tttatatcct
    10081 aggagaagtc tggcatacat ctcagccttg gctaaatgga gatgagttcc atgccatcat
    10141 gaattatcct ttatctgata gtatcaagga ctatttctta cgaggaatta agaagacaga
    10201 ccagttcatc gatgaaatca atggagagtc tatgtattac aagcagcaga tttcagaggt
    10261 catgtttaat ctcttggatt cacatgatac agagcgaatc ctgtggacgg ccaatgaaga
    10321 tgttcaactg gttaaatcag ccttagcctt tctcttttta caaaaaggaa caccgtgcat
    10381 ttattacgga accgagctag ccttgactgg aggaccagat ccagattgtc gtcgttgtat
    10441 gccttgggaa cgtgtatcaa gtgacaatga tatgctgaac tttatgaaga ggctgattaa
    10501 gattcggaaa tacgcgtcag taattatttc gcatggcaag tatagccttc aagaaatcaa
    10561 atctgattta gtagctctgg aatggaaata cgaaggacgg atcctcaaag caatattcaa
    10621 ccaatcaaca gaagattatc ttttagagaa agaagcagta gcactagcaa gcaattgcca
    10681 agaattggag aatcagcttg tcatctctcc agatggattt gtgattttct aaaaactagt
    10741 tgatgaagat tatggtacat ttcatatctt atatagtata ataaggctag ttactaaact
    10801 tgtaaaggag aacttaaatg aattgtagag gacatgaaac aagacaaaga attgttagag
    10861 attttgaagt ttagcctaaa gcacatatta agctgttagc aaatcaacaa aaacatagtg
    10921 atgcaggagc aactattgaa gatgaatatt atgtatttat cgctgagagt aaaattgatg
    10981 gcaagaagga agttattcag tgttgcatgg gtgcggcaag ggatttttta gaactaatta
    11041 atcacaaagg gctacctctt tttaatccgc ttgtaggtga ttctcatgta aataatagac
    11101 aagaatatga caatacaggg agtggaaatt tacaacctga aaagtggaat gaaactgcaa
    11161 agcagcttta taatgctata atgtggttga ttattttatg gaatgctaag ccggatacac
    11221 ctttatttaa ttttaaagac gaagtaatta agtataaaac atatgagcct tttgaaagca
    11281 gtataaaaag agtaaatact actataaaga atggtagtaa agggaaaact ctgactgaga
    11341 tgattaatgg ctacagagcg gataacgata ttagagatga aatttgtaac tttaatattc
    11401 tgaaaaataa aattcgtgat atgaaaaacc aacaaggaaa tacaatggaa tcttactttt
    11461 agttattgtt gaattttggg tattctataa aatatcctaa ttgagattta aatagtagac
    11521 tatacaatat agttaaaata tcagtaaaaa caacacttta ttgaggtatt ggatacgctt
    11581 tgctaatagc ctaataatca catgtggagt gttgctacaa cgaaaaaggt gataatcctt
    11641 gatttcaagc tattttataa gcattttgtc tttgtagata aaggcaattt tgacaataaa
    11701 aatcctaaaa ggtgaatcgt tatagatgta tttgtagata tcgtttgcgc atcgaaaaaa
    11761 ttaatacaag aataaatatt tatggctctt taggtgactt ttatagaagt aaagtttagg
    11821 atagaaaaac aagaaataat gcaccatttt tggtgcgtta tgctttttta tgctataatt
    11881 gaattataaa aataaaggag tttgctatga ttggaaagaa cataaaatcc ttacgtaaaa
    11941 cacatgactt aacacaaccc gaatttgcac gaattatagg aatttctcga aatagcttga
    12001 gtcgttatga aaatggaacg agttcagtct ctacggaatt aattgacatc atttgtcaga
    12061 agtttaatgt atcttatgtc gatattgtag gagaagataa aatgctcaat cctgttgaag
    12121 attatgaatt gactttgaaa attgaaattg tgaaagaaag aggtgctaat ctactttctc
    12181 gactctatcg ctatcaagat agtcagggaa ttagcattga tgatgaatct aatccttgga
    12241 ttttaatgag tgatgatcta tctgatttga ttcatacgaa tatctattta gtagaaactt
    12301 ttgatgaaat agagagatat agtggctatt tggatggaat tgaacgtatg ttagagatat
    12361 ctgaaaagcg gatggtagct taatggaaat ccaagattat actgatagtg aattcaaaca
    12421 tgctctagca aggaatcttc gttcactgac aagaggaaaa aagtccagta agcaacctat
    12481 agcgattttg cttggagggc aaagtggtgc tggtaagact acaattcatc gaattaaaca
    12541 gaaagaattt caaggaaata ttgttatcat agatggcgat agttttcgtt ctcagcatcc
    12601 acactattta gaactgcagc aagaatatgg caaagatagc gttgaataca ccaaagattt
    12661 tgcaggaaaa atggtagagt ctttagtaac aaaattgagt agtttgggat acaatctttt
    12721 gatcgaggga actttacgaa cgattgacgt tccaaaggaa acagcacaac tcttgaaaag
    12781 taagggatat gaagtacaat tagccttgat tgcgacaaag tctgagctgt cctatctgag
    12841 cactcttatc cgatacgaag aactgtacgc tatcaatcca aatcaagcac gcgcaactcc
    12901 aaaagaacat catgatttca ttgtaaatca tctagttgat aatacacgac aattggaaga
    12961 actggctatc tttgaaagca ttcaaattta tcaacgagat agaagttgtg tatatgattc
    13021 aaaagaaaat acaacttcag cagcagaagt gctacaagaa tacctcttcg gaaaatggag
    13081 caaggtagag gaagagatgt tgaaggtggg ggaaaagaga cttaatgaat tacttgaaaa
    13141 ataaacaatt gatattttta ggagaataga aatgagaggg tttaataaca agataaagtc
    13201 tgtttatcaa gaactaacaa attccaaaga gaaattcggt agctttcaca agactttaat
    13261 tcatttgcat acacctgttt cttatgatta caagctattt tctaattgga ctgcaacgaa
    13321 atatagaaaa att
//
LOCUS       DAVHSO010000060        12884 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.061, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000060 DAVHSO010000000
VERSION     DAVHSO010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12884)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12884)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12884
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.061"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            42..847
                     /locus_tag="VVR18_001790"
                     /pseudo
     CDS             42..847
                     /locus_tag="VVR18_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(931..2133)
                     /gene="rpsA"
                     /locus_tag="VVR18_001791"
     CDS             complement(931..2133)
                     /gene="rpsA"
                     /locus_tag="VVR18_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S1"
                     /protein_id="HEU6033268.1"
                     /translation="MNEFEDLLNSVSQVETGDVVSAEVLTVDATQANVAISGTGVEGV
                     LTLRELTNDRDADINDFVKVGEVLDVLVLRQVVGKDTDTVTYLVSKKRLEARKAWDKL
                     VGREEEVVTVKGTRAVKGGLSVEFEGVRGFIPASMLDTRFVRNAERFVGQEFDTKIKE
                     VNAKENRFILSRREVVEAATAAARAEVFGKLAVGDVVTGKVARITSFGAFIDLGGVDG
                     LVHLTELSHERNVSPKSVVTVGEEIEVKILDLNEEEGRVSLSLKATVPGPWDGVEQKL
                     AKGDVVEGTVKRLTDFGAFVEVLPGIDGLVHVSQISHKRIENPKEALKVGQEVQVKVL
                     EVNADAERVSLSIKALEERPAQEEGQKEEKRAARPRRPRRQEKRDFELPETQTGFSMA
                     DLFGDIEL"
     gene            complement(2295..2366)
                     /locus_tag="VVR18_001792"
     tRNA            complement(2295..2366)
                     /locus_tag="VVR18_001792"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2332..2334),aa:Gln,seq:ttg)
     gene            complement(2376..2456)
                     /locus_tag="VVR18_001793"
     tRNA            complement(2376..2456)
                     /locus_tag="VVR18_001793"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(2420..2422),aa:Tyr,seq:gta)
     gene            complement(2506..2736)
                     /locus_tag="VVR18_001794"
     CDS             complement(2506..2736)
                     /locus_tag="VVR18_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000037109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2969 domain-containing protein"
                     /protein_id="HEU6033269.1"
                     /translation="MSKKDKKIEIQVADAKVNVGKDSFEGYTLTIGKKVIGEIAELDG
                     QFAIIKNGNVDSFYKKLEKAVEILIENYNLAK"
     gene            complement(2904..3548)
                     /gene="pcp"
                     /locus_tag="VVR18_001795"
     CDS             complement(2904..3548)
                     /gene="pcp"
                     /locus_tag="VVR18_001795"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HEU6033270.1"
                     /translation="MKILVTGFNPFGGEKINPALEAVKLLPSEINGAEVRWVEIPTVF
                     YKSSEVLEAEILRYQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPI
                     RIDGASAYFSSLPIKAMVQAIKKQGLPAVVSNSAGTFVCNHLMYQALYLVDKKFPNMR
                     AGFMHIPYMMEQVVNKPNTAGMSLCDIVRGIEVAIEAIVDYKDKDLQLVGGETH"
     gene            complement(3563..4486)
                     /locus_tag="VVR18_001796"
     CDS             complement(3563..4486)
                     /locus_tag="VVR18_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HEU6033271.1"
                     /translation="MTELAKQLLELTYIVIGCQFLHTAYCSYKDKTNPVRLGTSAFWT
                     LLSITFIGGSYMPNMSIGIIVILLSLLTLFKQVRIGTLPSLDEMKANIESNRLKNKIF
                     IPVMLMAILALVLAQMIPEFSKISISLAALFATISVLVITNSHPKSLLSENNRMTQQV
                     STSGIVPQLLGALGAIFTVAGVGDVISHLISGIVPSDSRFIGVLAYVLGMVLFTMIMG
                     NAFAAFTVITAGVGVPFVFALGANPIVAGALAMTAGYCGTLLTPMAANFNALPAALMD
                     MKDQNGVIKAQAGVALVMIVIHIFLMYFLAF"
     gene            complement(4483..5172)
                     /locus_tag="VVR18_001797"
     CDS             complement(4483..5172)
                     /locus_tag="VVR18_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HEU6033272.1"
                     /translation="MEWIRLIGIAIIVVGFILKFDTIATVVLAGLVTALVSGVSLVEF
                     LEILGKEFSNQRVLTIFMVTLPLVGLSETFGLKQRSIDLIRKIKGLTVGNFYTVYFFI
                     RELAGFFSIRLGGHPQFVRPLVQPMGEAAAESQLGRKLTEVEDETIKARAAANENFGN
                     FFAQNTFVGAGGVLLIGGTLDQLGYESNYAGIASTSIIVAVITLIVVGIYNYLFDKKL
                     ISKKTRGGEQK"
     gene            complement(5237..5941)
                     /locus_tag="VVR18_001798"
     CDS             complement(5237..5941)
                     /locus_tag="VVR18_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6033273.1"
                     /translation="MVLSTSAILVACGKTDKEADAPTTFSYVYAVDPASLGYSIATRT
                     SRTDVIGNVIDGLMENDKYGNVAPSQKDYDLNSTGWAPSYQDPASYLNIMDPKSGSAM
                     KHLGITKGKDKDVVAKPGLDKYKKLLEDAVSETTDLEKRYEKYAKAQAWSTDSSLLMP
                     TASSGGSPVVSNVVPFSKPYSQVGIKGEPYIFKGMKLQKDIVTTKEYNEVFKKWQKEK
                     LESNSKYQKELEKYIK"
     gene            complement(5997..7019)
                     /locus_tag="VVR18_001799"
     CDS             complement(5997..7019)
                     /locus_tag="VVR18_001799"
                     /EC_number="2.6.1.42"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="HEU6033274.1"
                     /translation="MTVTIDWENLGFSYMKLPYRYLAHFKNGQWDQGELTEDATLHIS
                     ESSPSLHYGQQAFEGLKAYRTKDGSVQLFRPDENAKRLQRTCDRLLMPQVPTDMFVEA
                     CKAVVRANEEYVPPYGTGGTLYLRPLLIGVGDIIGVKPAEEYIFTIFAMPVGNYFKGG
                     LVPTNFLIQDEYDRAAPNGTGAAKVGGNYAASLLPGKMAKSRHFSDVIYLDPSTHTKI
                     EEVGSANFFGITADNEFVTPLSPSILPSITKYSLLYLAEHRLGLTPIEGDVPIDNLDR
                     FVEAGACGTAAVISPIGGIQHGDDFHVFYSETEVGPVTRKLYNELTGIQFGDIEAPEG
                     WIVKVD"
     gene            complement(7151..9622)
                     /gene="parC"
                     /locus_tag="VVR18_001800"
     CDS             complement(7151..9622)
                     /gene="parC"
                     /locus_tag="VVR18_001800"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit A"
                     /protein_id="HEU6033275.1"
                     /translation="MSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
                     LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMH
                     GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFP
                     NLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAI
                     IQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVR
                     VNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDN
                     FTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALI
                     RASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLA
                     AIIGDERTMYNLMKKELREVKKKFATPRLSSLEDTAKAIEIDTASLIAEEDTYVSVTK
                     AGYIKRTSPRSFAASTLEEIGKRDDDRLIFVQSAKTTQHLLMFTSLGNVIYRPIHELA
                     DIRWKDIGEHLSQTITNFETNEEILYVEVLDQFDDATTYFAVTRLGQIKRVERKEFTP
                     WRTYRSKSVKYAKLKDDTDQIVAVAPIKLDDVVLVSQNGYALRFNIEEVPVVGAKAAG
                     VKAMNLKEDDVLQSGFICNTSSFYLLTQRGSLKRVSIEEILATSRAKRGLQVLRELKN
                     KPHRVFLAGAVAEQGFVGDFFSTEVDVNDQTLLVQSNKGTIYESRLQDLNLSERTSNG
                     SFISDTISDEEVFDAYLQEVVTEDK"
     gene            complement(10042..11985)
                     /gene="parE"
                     /locus_tag="VVR18_001801"
     CDS             complement(10042..11985)
                     /gene="parE"
                     /locus_tag="VVR18_001801"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="HEU6033276.1"
                     /translation="MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHL
                     VWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTIL
                     HAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLK
                     KIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDE
                     AIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVN
                     NVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPE
                     EHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAA
                     RKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQ
                     AILPLRGKVVNTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDAD
                     TDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEE
                     LRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGD
                     KVEPRRKWIEDNVKFTLEEATVF"
     gene            12121..12762
                     /gene="plsY"
                     /locus_tag="VVR18_001802"
     CDS             12121..12762
                     /gene="plsY"
                     /locus_tag="VVR18_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HEU6033277.1"
                     /translation="MITIVLLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNT
                     FRILGKKAGMATFVIDFFKGTLATLLPIIFHLQGVSPLIFGLLAVIGHTFPIFAGFKG
                     GKAVATSAGVIFGFAPIFCLYLAIIFFGALYLGSMISLSSVTASIAAVIGVLLFPLFG
                     FILSNYDSLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK"
     gene            complement(12805..>12884)
                     /locus_tag="VVR18_001803"
     CDS             complement(12805..>12884)
                     /locus_tag="VVR18_001803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU6033278.1"
                     /translation="YYNNKRIKVKLKGLSLVQYRTKSFG"
BASE COUNT         3729 a         2913 c         2261 g         3981 t
ORIGIN      
        1 gttgaaacag tccggggagt gactgtttca atcgggagat ggagatgagc tttattgcgc
       61 aagattttga aaagctcgat atcatcactg ttcttgaggg tagaacacaa gctgtcatcc
      121 gagatcactt tcttaaatat gatagagccg tccgatgtcg cgtcaaaatc attactatgg
      181 atatgtttag tccttactat gacttggcta aacagcttcg ctttcaaatt tctaggctca
      241 ggctgaaaca gtctcccagg ctgtttcact cccgaatgct aaaatcgttc ttgatcgctt
      301 tcacattgta caacatctta gccgtgctat gagtcgtgtg catgtccaaa tcatgaatca
      361 gtttcatcga aaatcccatg aatacaaggc tatcaagcgc tactggaaac tcattcaaca
      421 ggatagccgt aaactgagtg ataagcgatt ttatcgtcct acttttcgta tgcacttaac
      481 caataaagag attttagaca agcttttgag ctattcacaa aacttgaaac accactatca
      541 gctcttgctt tttcacttcc agaataagga accagagaaa cttttcggac ttattgagga
      601 caatctgaag caagttcatc ctatttttca gactgtcttt aaaaccttct tcaaagataa
      661 ggaaaagatt atcaacgccc ttcaactaca ctattctaat gccaaactgg aagcgaccaa
      721 taatctcatc aaacttatca agcgcaatgc ctttggtttt cgaaactttg aaaatttcaa
      781 aaaacggatt gttatcactt tgaacatcaa aaaagaaagg acgaaatttg tcctttctcg
      841 agcttagctt ttttcaaccc actacagttg acaaagagcc gaaaaatccc ttgtttagta
      901 aacaaaggat tttgtgaatt ttcaatttga ttaaagttcg atatcaccaa acaaatcagc
      961 cattgaaaat cctgtttgtg tttctggaag ttcgaaatca cgcttttctt gacgtcttgg
     1021 acgacgtgga cgagcagcac gtttttcttc tttttgtcct tcttcttggg ctggacgttc
     1081 ttcaagagct ttaatagaaa gtgatacgcg ttctgcatct gcgttaactt caagaacttt
     1141 aacttgaact tcttgaccaa ctttaagagc ttcttttgga ttttcaatcc gtttgtgtga
     1201 aatttgtgat acgtgaacaa gtccatcgat acctggcaat acttcaacaa atgcaccgaa
     1261 gtcagtcaaa cgtttaactg ttccttctac tacatcacct ttagccaatt tttgctcaac
     1321 gccatcccat ggtcctggta ctgttgcttt aagtgaaagt gatacacgtc cttcttcttc
     1381 gttaagatca aggattttca cttcaatttc ttcaccaaca gttacaactg attttggtga
     1441 tacgttacgt tcatgtgaca attcagtcaa gtgaaccaat ccgtcaacac caccaaggtc
     1501 gatgaaagcg ccgaagcttg tgatacgagc aactttacca gttacaacat caccaacagc
     1561 caatttaccg aatacttcag cgcgagctgc tgcagtagct gcttcaacaa cttcacgacg
     1621 tgaaaggatg aagcggtttt ctttagcgtt aacttctttg attttagtat caaattcttg
     1681 acctacaaaa cgctcagcgt tacgtacgaa acgagtatcc aacattgaag ctgggataaa
     1741 tccacgaaca ccttcaaatt ctactgaaag tccaccttta acggcacgcg ttcctttaac
     1801 agtaacaact tcttcttcgc gaccaacaag tttgtcccat gctttgcgag cttcaaggcg
     1861 ttttttagat acaaggtatg taactgtatc agtatcttta ccaactactt gacgaagtac
     1921 aagaacatcc aatacttctc ctactttaac aaagtcattg atatctgcat cacgatcgtt
     1981 tgtcaattcg cgaagagtca agacaccttc aacaccagtt ccagagattg caacgttagc
     2041 ttgagtcgca tcaactgtca atacttcagc actaacaaca tcaccagtct caacttgact
     2101 aacgctattt agcaaatctt caaattcgtt catctaaaaa atcctccaac aatcaagttt
     2161 ttcttaaact tgacatactt ataatttttt tcctaagcac ccgcaaggac atgttcatat
     2221 cattcacgtc tttcaattat aaaaataaaa taccctaaga tattttgctt tttatcttga
     2281 ttattaccta agaactgggg tagctggatt cgaaccaacg catgagggag tcaaagtccc
     2341 ttgccttacc gcttggctat accccattaa tgaaatggag agagagggat tcgaaccccc
     2401 gaacccgaag gagcggattt acagtccgcc gcgtttagcc tcttcgctat ctctcctaca
     2461 atcaacatgg actattatat catgaaaatt tcaaaaaaac aagacttatt ttgctaaatt
     2521 ataattttca atcaaaattt ccacagcttt ttccaatttt ttataaaaac tatcgacatt
     2581 cccattcttt ataatggcaa attgtccgtc taattcggca atttctccga taactttttt
     2641 accgatagtc aatgtataac cttcaaaact gtctttacca acattaactt tggcatccgc
     2701 tacttgaatt tcgatttttt tatctttctt gctcatttca tacctctctt cactttttct
     2761 attttacaag aaaatcctaa aactagcaag aaaaaactct atatcaggct tctctgatat
     2821 agagttttat gtaaacaacc tcaatcgatt tagcatagct aatagttagt aaacaagcat
     2881 aattgactat cctttttagg ttatcagtga gtctcaccgc ctactaactg caaatcctta
     2941 tctttgtagt ctacaatagc ttcaatagct acctctatgc ctcttacaat atcacataga
     3001 ctcattcctg cagtattcgg cttatttact acttgttcca tcatatatgg aatatgcatg
     3061 aaacctgctc tcatattagg gaatttttta tccactaaat aaagagcttg gtacatcaaa
     3121 tgattgcaaa caaaggttcc tgcactattg gatacaactg ccggaagtcc ctgttttttg
     3181 atagcttgta ccatcgcttt gataggtaaa ctactaaaat aggccgatgc tccatcaata
     3241 cgaatcggtg tatcaattgg ttgattgcct tcgttatcag gtatgcgagc atcatcttga
     3301 ttaatagcca ctcgttcagg tgttaagccg gtcctgccgc ctgcttgtcc aatacaaagt
     3361 acagcatctg gttgatatcg taatatttct gcctctaaaa cttctgacga cttataaaaa
     3421 accgttggaa tttctaccca gcgaacttca gccccattaa tctcagatgg taataatttt
     3481 acagcctcca aagctggatt aatcttttca cctccaaaag gattaaaacc tgtaaccaat
     3541 attttcattt tattttcctt tactaaaatg cgagaaagta cattaagaat atgtgaataa
     3601 caatcattac tagagcaaca cctgcttgag cctttataac gccattctga tctttcatat
     3661 ccatcaatgc tgctggtaga gcgttaaaat tagcagccat tggggtcaat aaggtcccac
     3721 aataacctgc tgtcatggca agagcaccag ccacaattgg attagctccc agagcaaata
     3781 caaagggaac tccaacacct gctgtaataa cggtgaatgc tgcaaaagca tttcccataa
     3841 tcattgtgaa tagaaccatt ccaagaacat aggccaaaac tcctataaag cgactatctg
     3901 aaggaacaat accgctaatc agatgagaga taacatcacc aacacctgct acagtaaaaa
     3961 tagcccccaa agcccctaat aattgaggaa caataccact tgttgaaact tgctgagtca
     4021 ttcgattatt ttctgataac agactcttag ggtgactatt ggtaatcaca agaacagaaa
     4081 ttgtagcaaa caaggcggca aggctaatcg aaatcttgct aaattctgga atcatttgcg
     4141 ctaagaccaa cgcaagtatt gccatcagca taactggaat aaaaatttta tttttcaacc
     4201 tgttagattc aatattggct ttcatttcat ctaaggatgg caaggttccg atacggactt
     4261 gcttaaacaa tgttaacagc gataatagga ttacaataat accaatactc atatttggca
     4321 tataggaacc acctataaac gtaatagaca atagagtcca aaatgcagat gtcccaagtc
     4381 gaactgggtt tgttttatct ttataactac aataggctgt atggagaaat tgacaaccaa
     4441 tcacaatata ggtcaactct aatagttgct ttgccaactc tgtcattttt gttctcctcc
     4501 cctagtcttt tttgatatca attttttatc aaataaataa ttgtaaatcc ccactacaat
     4561 aagtgttata acagcaacaa taatagatgt agaagcaatc cctgcataat tgctttcata
     4621 gcctaactga tctaatgttc cccctatcaa gaggactccc ccagcaccta caaacgtatt
     4681 ttgagcaaag aaatttccaa aattttcatt cgcagccgca cgcgctttta ttgtctcatc
     4741 ttcaacctct gttaactttc tacctaattg agactctgca gctgcttctc ccataggttg
     4801 aaccaaaggt ctgacaaact gagggtgtcc tcctagacga attgaaaaga aaccagctaa
     4861 ctctcgaata aaaaaataaa ctgtatagaa gtttccaact gtcagacctt taatctttcg
     4921 aatcaaatcg attgatcgtt gcttgagtcc aaaggtttct gacagcccca caagaggcaa
     4981 ggtaaccata aaaatcgtga gcactcgctg attgctaaat tcttttccca aaatctccaa
     5041 aaattcaacg agagaaacac ctgaaactaa agctgtaacc aaaccagcta agactactgt
     5101 tgcaattgta tcaaatttta aaataaaacc cacaacaatg attgctattc ctattaatct
     5161 aatccactcc atatcaaact cctttatatt caaaatgaca gtattttaaa aattttatca
     5221 agatcaatac cattccttat ttaatgtatt tttctagttc tttttggtat ttgctattgg
     5281 attccaattt ttctttttgc cattttttaa aaacctcgtt atattctttt gttgtaacaa
     5341 tatctttttg caatttcatt cctttaaaga tatatggttc ccccttaata ccaacttgtg
     5401 agtatggttt tgagaatggt actacgttac ttacaactgg agaaccacca gatgaagctg
     5461 ttggcatcaa taatgaacta tctgtcgacc aagcttgagc tttggcatat ttttcatatc
     5521 tcttctctag gtcagtggtc tcagaaacag catcttctaa caatttctta tatttatcca
     5581 aaccaggttt agctacaaca tccttatctt ttcctttcgt aataccaagg tgtttcatgg
     5641 cagaaccaga ttttggatcc ataatattca agtaagacgc tggatcttga tagcttggag
     5701 cccatcctgt actattcaaa tcatagtctt tttgagaagg agcaacattg ccgtatttat
     5761 cattttccat caaaccatca ataacatttc caataacgtc tgtcctcgat gttcgagtcg
     5821 ctatactgta gcccaatgat gctggatcta ctgcatagac ataagaaaat gttgtcggtg
     5881 catctgcttc tttatcagtt tttccacaag ccactaaaat agctgacgtg ctcaggacca
     5941 ctcctgctgt taagagccac tttttctatt tcataaaaaa tctcctttgg tttattttaa
     6001 tctactttta caatccaacc ttctggcgct tcaatatcgc caaactgaat acccgtcaat
     6061 tcattatata atttacgcgt cacaggacct acttctgttt cactatagaa tacatggaaa
     6121 tcatcaccat gttgaatacc tccaattgga gaaataaccg ctgctgtacc acaggcacct
     6181 gcctctacaa aacggtcaag attatcaatt ggaacatcac cctcaatagg agttaatccc
     6241 aagcgatgtt ctgccaaata aagcaaggaa tacttggtaa tagatggcaa gatagatgga
     6301 ctcaatggtg ttacaaattc attatcagct gtaattccaa agaagttagc tgatccgact
     6361 tcttcaatct ttgtatgagt tgatgggtcc agatagataa catctgagaa atgacgtgac
     6421 ttggccattt ttcctggtaa gagacttgca gcatagtttc caccaacctt agccgcacct
     6481 gtaccatttg gtgctgcacg gtcgtactca tcctgaatca agaagttggt tgggaccaaa
     6541 ccacctttaa agtaatttcc aactggcata gcaaagatgg tgaaaatgta ctcttctgcc
     6601 ggttttaccc cgataatatc tccgacacca atcaaaagag ggcgaagata taaggttcca
     6661 cctgttccgt atggtggtac gtattcttca ttcgcacgga caactgcttt acaagcttct
     6721 acaaacatgt ctgtcggaac ttgtggcatc aagagacggt cacatgtacg ttgcagacgt
     6781 ttagcatttt catcaggacg gaacagttga acactgccat ccttagtacg ataagctttc
     6841 aaaccttcaa atgcttgttg tccatagtga agacttggag aagactctga aatatgcaaa
     6901 gttgcatcct ctgtaagctc tccttgatcc cattgtccat ttttgaaatg agcaagatag
     6961 cgataaggta atttcatata ggaaaaaccg aggttttccc aatcaatcgt tactgtcata
     7021 ttccactcct tattctaaaa acctatttct tatattctac actatttttc taaaatagca
     7081 agtatatttt gtaattttca gaaaatttct ccaataaaaa ccagctctta gaactgattc
     7141 ttcatttcac ttatttatct tcagtaacta cttcctgaag ataagcgtca aaaacttctt
     7201 catctgaaat cgtgtcagaa atgaagcttc cattgctagt gcgttctgac aagttcaagt
     7261 cttgcaatcg gctttcatag attgttcctt tattggattg gacaagcaga gtttggtcgt
     7321 tcacatccac ttccgtactg aagaaatcgc caacaaatcc ttgctctgca actgctcctg
     7381 ccaagaagac acgatgcggt ttgtttttca actcacgcaa gacttgtaat cctcgtttgg
     7441 cacggctggt tgctagaatt tcctcaatgg aaacacgttt caagcttcca cgctgggtca
     7501 agaggtagaa ggacgaagta ttacagataa agccagattg gaggacatca tcttctttca
     7561 aattcatagc cttgacacct gctgccttag caccgacaac cggaacctct tcgatattga
     7621 aacgcagggc ataaccattt tgactaacca agacaacatc atctagttta atcggagcca
     7681 ctgctacaat ctgatctgta tcgtctttga gcttagcata cttgacagac ttagatctat
     7741 aggtccgcca tggagtgaat tcttttcgct ctacccgttt gatttgacca aggcgagtca
     7801 ctgcaaagta ggttgtcgca tcgtcaaact gatccagtac ttccacataa aggatttctt
     7861 cattcgtttc aaagtttgtg atggtttggc tcagatgctc tccgatgtcc ttccaacgaa
     7921 tatctgccaa ctcatggatt ggtctgtaga tgacatttcc aagacttgtg aacatcaaga
     7981 ggtgctgggt tgtcttggca gattgaacaa aaatcaaacg gtcatcatca cgcttgccaa
     8041 tttcttccaa ggtggaagcc gcaaaggaac gtggactggt acgcttgatg taacctgcct
     8101 tggtcacgct gacgtaggta tcttcctcag cgataagact agctgtatca atctcaattg
     8161 ctttcgcagt atcttctaaa gaactcaaac gaggagttgc aaatttcttc ttgacctcac
     8221 gaagttcttt cttcatgaga ttgtacatag tcctttcatc accgataata gccgccagca
     8281 tagcaatctt ctcacgaagc tctgcttctt cttcctgcaa gacaaccaca tcggtattgg
     8341 tcaaacggta cagttgcaaa gttacgatag cctcagcctg ttcttccgta aaatcatagc
     8401 taactttgag gttttccttg gcgtccgcct tattctcaga agcacggata agagcaatga
     8461 cttcatccaa aatcgaaatc acacgaatca aaccttcgac gatatggaga cgtttctcag
     8521 ccttttcttt gtcaaagcgt gaacgcgcca aaatcacttc tcgacggtga gcgatatagc
     8581 tagacaggat tggaacaatc ccaacctgac gaggtgtgaa attgtcaatc gccaccatat
     8641 taaagttgta gttgatttgt aggtcggtgt acttaaataa gtagttgaga acaagctcag
     8701 tattagcgtc tttcttaagt tcgatagcga tacgaagacc atcacggtca gactcatcac
     8761 gaacctcagc aatcccagct accttgttat taacacgaac atcatcgatt ttcttgacta
     8821 gattggcctt attgatttca taaggaatct cagtaataac gatttgttcc ttaccacctt
     8881 ttagcttttc aatttcagtc ttggaacgaa caaccacgcg ccctttccca gtctcataag
     8941 ctttcttgat ttcatcacga ccctgaataa tagcccctgt agggaagtct ggtccaggca
     9001 agaattccat gagtttatca atctttgcag ttgggtggtc aatcatgtaa actgcagcat
     9061 ctatgacctc agctaaatta tggggaggaa tgtctgtggc ataaccagcc gaaatcccag
     9121 tcgaaccatt gaccaagagg tttggaaagg ctgctggcaa gaccgttggt tctttctccg
     9181 tatcgtcaaa gttccatgca aaaggaactg tctttttctc gatatcctga agaaggtagc
     9241 ctgcaatttc agacaaacgt gcctcagtat aacgcatagc cgcaggagga tctccgtcca
     9301 tagaaccgtt attaccgtgc atttcaacta gaatctcacg atttttccag ttctgtgaca
     9361 tacgaaccat ggcatcatag atagaagaat ccccgtgtgg gtggaaattc cccatgatgt
     9421 tcccgactga cttggccgac ttacggtagc tcttgtcaaa agtattgcta tccttattca
     9481 tagaataaag aatacggcgc tgaaccggct tcaacccatc acgaatatct ggcaaagccc
     9541 ggtcttgaat aatgtacttg gagtagcgac caaagcgctc tcccatgatg tcctccaggg
     9601 acatattttg aatgttagac ataagataca aagcccataa aataccaagt gaaaatagaa
     9661 aattcttgaa gtaagcaaac tcacaagaga atttatcttt ttcacacagt atctagggcg
     9721 tgttcaactc ctttcaaaga atgtagagta ggtttttatg cagtaaaaga tattttacgg
     9781 gaattcctcc cgtgttcagt tacgataagt aaccaaacta tcctgtttgt atttttcaat
     9841 atgaaaatct ggttttccaa aattagtctt agtttgtgtc ttagtcgctc ccttaaacgc
     9901 ctctttgaga taagcactca tagcagattc ttcattaata atcctgcaat tttttcaaac
     9961 caagattttc aaactgcttt ttcacatagt cattcacatc cgactctaat ttccagttta
    10021 ctaacatatt attttctttc attaaaacac tgtcgcttct tctagcgtaa acttgacatt
    10081 atcttcaatc catttacggc gtggttctac cttatctccc atgagaacat tgacgcggcg
    10141 ttcggcgcgc gctaaatctt caattgtgac acggatgagg gtacgtgttt ctgggttcat
    10201 ggttgtttcc cagagctggt ccgcattcat ctcaccaagt cctttgtatc gttggagggt
    10261 agcgccttta ccgaactgtt tacggagttc ttctagttct ccgtccgtcc aagcgtaggc
    10321 cacttcttct ttcttgcctt tacctttgga catcttgtaa agaggtggga gggcaatata
    10381 gacatgacct gcctcgacta gcggacgcat gtaacggtag aaaaatgtca agagcaaggt
    10441 ctggatatgg gcaccgtcgg tatccgcatc ggtcatgata atgatcttat catagttggc
    10501 atcttcaata gagaagtctg ctccaacacc cgcaccaatg gtataaatca tggtattgat
    10561 ctcttcattt ttgaggatat ccgccatctt ggccttggct gtattgacaa ccttaccacg
    10621 aagaggtaga atagcctgga acttgcggtc acgaccttgt ttggcagaac caccggcaga
    10681 gtccccctca actagataga gttcattctt agcaggattc ttagattggg ctggggtcaa
    10741 tttcccagac aacaagccct tatctttctt gtttttcttc ccatttcggc tctcatcacg
    10801 cgccttacgt gctgcttcac gagcatcacg agccttgata gccttgcgga tgaggttaga
    10861 agctaattcc ccattttcca taaggaaaaa ggtcaactta tcagccacta ttccatccac
    10921 aactgggcga gctagggggc ttcctagttt atccttggtc tgtccttcaa actgcaagtg
    10981 ttcttcagga actaagatag aaagaacggc cgctagtccc tcacgatagt ctgaaccttc
    11041 aaggttttta tctttttcct tgagaagacc tgttttacgt gcatagtcat tcatgacctt
    11101 ggtaatggca gacttgagtc ctgtctcgtg cgttccaccg tccttggtgc gaacgttatt
    11161 gacaaaggat agaatgttat ctgagaatcc gtcattgtac tggagggcta cttccacttg
    11221 aaaaccattg tcttcccctt caaagtaaag aactggcgtc aagatttcct tatcttcgtt
    11281 gagataagaa acaaaatctt gtactccatt ctcatagtgg aactcaatcg cttcatctgt
    11341 tcgcttgtcc gttaaagaca aggtcacatt tttcaagaga aaggctgatt cattaaggcg
    11401 ctctgaaatg gtattgtact tgaaatctgt cgtagaaaag atagtcgcgt caggcataaa
    11461 agtaactttg gtgcctgttt tagacttggg tgctgtaccg attttcttca aagtcgtgac
    11521 aggttttcca ccattttcaa aacgttgctt gtaaactgcg ccatcacggg taatttcaac
    11581 ttctaaccag ctagaaaggg cgttaacaac ggaagaaccc actccgtgaa gtccacctga
    11641 tgtcttatag ccaccttgac cgaatttccc tccggcatga agaatggtaa agataacctc
    11701 aacagttgga attcccatag cgtgcatacc tgtcggcatc ccacgtccat ggtcttgaac
    11761 cgttagacta ccgtctttat tgatagttac atcaatacga tcaccaaacc cagacaaggc
    11821 ttcatcgact gcattatcaa cgatttccca aactaggtga tgaagaccag cgccatcggt
    11881 cgatccaata tacatccctg gacgttttcg gaccgcatcc aacccttcta gcacctgaat
    11941 agcatcatca ttataattgt taatattgat ttcctttttt gacacaagga acctcctatt
    12001 cgttcatctt tactattcta caggttttcc aaggattttg caaaattttt ctttctccga
    12061 tgtgacaatt ttagcagaga ttctctgctt ttctttccca attcatgata taataggagt
    12121 atgattacaa tagttttatt aatcctagcc tatctgctgg gttcgattcc atctggtctc
    12181 tggattggac aagtattctt tcaaatcaat ctacgcgagc atggttctgg taacactgga
    12241 acgaccaaca ccttccgcat tttaggtaag aaagctggta tggcaacctt tgtgattgac
    12301 tttttcaaag gaaccctagc aacgctgctt ccgattattt ttcatctaca aggcgtttct
    12361 cctctcatct ttggactttt ggctgttatc ggccatacct tccctatctt tgcaggattt
    12421 aaaggtggta aggctgtcgc aaccagtgct ggagtgattt tcggatttgc gcctatcttc
    12481 tgtctctacc ttgcgattat cttctttgga gctctctatc ttggcagtat gatttcactg
    12541 tctagtgtca cagcatcgat cgcggctgtt atcggggttc tgctctttcc actttttggt
    12601 tttatcctga gtaactatga ctctctcttc atcgctatta tcttagcact tgctagtttg
    12661 attatcattc gtcataagga caatatagct cgtatcaaaa ataaaactga aaatttggtc
    12721 ccttggggat tgaacctaac ccatcaagat cctaaaaaat aaaacgccag ttctgtactg
    12781 cccccaaaca gttagacaaa taatttatcc aaaggattta gttctgtatt gcacaaggct
    12841 aagtcctttt agttttacct taattcgttt attgttgtag taat
//
LOCUS       DAVHSO010000061        12686 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.062, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000061 DAVHSO010000000
VERSION     DAVHSO010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12686)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12686)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12686
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.062"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(309..1493)
                     /gene="cps4L"
                     /locus_tag="VVR18_001804"
     CDS             complement(309..1493)
                     /gene="cps4L"
                     /locus_tag="VVR18_001804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4L"
                     /protein_id="HEU6033279.1"
                     /translation="MKIKTDYSDIHFKDNGKLKLLIIVGTRPEIIRLSSVITKCRKYF
                     DVILAHTGQNYDYNLNGIFFDNLGLDTPDVYMDAVGDDLGATVGNIINTSYKLMNQIK
                     PDALLILGDTNSCLSAIAAKRLHIPIFHMEAGNRCKDECLPEETNRRIVDIISDVNLA
                     YSEHARKYLHECGLPKERTYVTGSPMAEVLHKNLSAIESSDIHERLGLKKGGYILLSA
                     HREENIDTDKNFISLFTAINQLAEKYNMPILYSCHPRSKKRLQESGFKLDKRVIQHEP
                     LGFHDYNCLQMNAFVVVSDSGTLPEESSFFTSQGYPFPAVCIRTSTERPESLDKAGFI
                     LAGIDENSLLQAVETAVSLAEDEDFGLPVPDYVEENVSTKVVKIIQSYTGIVDKIVWR
                     KS"
     gene            complement(1494..2723)
                     /gene="cps4K"
                     /locus_tag="VVR18_001805"
     CDS             complement(1494..2723)
                     /gene="cps4K"
                     /locus_tag="VVR18_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4K"
                     /protein_id="HEU6033280.1"
                     /translation="MPLKILVTGSKGFVGKNLICTLEALKDGRDRTRPNLEIGEIFQY
                     DRDTDPILLDEYCKKADFVFHLAGVNRPQNPDEFMEGNYGFSSRLLEILEKYENTCPV
                     LLSSSTQASLEGRFSNSIYGQSKLVGEELFFEYGKKTGAPVLVYRFPNLYGKWCRPNY
                     NSAVATFCHNLAHDLPIQVNDPSVELELLYIDDLIQECLTALEGNPHRCNLDGLQILP
                     SPSGNYCYVPTTHRATLGEIVSLLETFKKQPNSLVMPEIPQGSFKKKLYSTYLSYLPV
                     DKFKFPLKMNIDERGSFTELLKTENKGQFSVNISKPGITKGQHWHHSKWEFFMVVSGR
                     ALIQERRIGLDENGQEYPILNFEVSGDKIEAIHMIPGYAHNIINLSDTENLVTVMWAN
                     ESFDPRHPDTFFEQVEK"
     gene            complement(2742..3953)
                     /locus_tag="VVR18_001806"
     CDS             complement(2742..3953)
                     /locus_tag="VVR18_001806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002992300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="HEU6033281.1"
                     /translation="MKIAVAGTGYVGLSIAILLAQYHKVIAVDVIPEKVELINRRQSP
                     IKDDDIETYLVEKELDLVATLDGNEAYRDADFVIIAVPTNYDSKKNYFDTSVVEAVIE
                     QIIAVNLKATIVIKSTIPVGYTESLRTRFGQFKILFSPEFLRESKALYDNLYPSRIIV
                     GADLRDTEQVVQAERFATLLQEGSLKPDVETLIMGVTEAEAVKLFANTYLALRVSYFN
                     ELDTYAEIKGLDTKSIIDGVGLDPRIGSHYNNPSFGYGGYCLPKDSKQLLANYHDVPQ
                     NMMTAIVESNRTRKYFIADRILKNALELSDGNQTIIVGVYRLTMKSGSDNFRQSSIQG
                     VIKCLKAKGVEVIIYEPTLEDHSFFFGNQVVNDLEVFKSSSQVIVANRMEKSLYDVLE
                     KVYTRDIFQRD"
     gene            complement(3962..4999)
                     /locus_tag="VVR18_001807"
     CDS             complement(3962..4999)
                     /locus_tag="VVR18_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000494439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEU6033282.1"
                     /translation="MFTKKTLLITGGTGSFGNAVLKRFLGTDISEVRIFSRDEKKQDD
                     MRHEFQAKMPEVADKIRFYLGDVRDLASVKNAMIGVDYVFHAAALKQVPSCEFFPVEA
                     VKTNVLGTENILTAAIEAGVKQVICLSTDKAAYPVNAMGTSKAMMEKIAVAKSRTVEE
                     DQTKVCVTRYGNVLCSRGSVIPLWIDQIKQGNPITITEPSMTRFIMSLEEAVDLVLFA
                     FEKGKTGDILVQKAPACTIEVLAQAVTELFAPNQDIKVIGIRHGEKMYETLLTTEECT
                     NAIDLGGFYRVPSDNRDLNYDKYFNEGDAKRNPLIEFNSSNTELWNVEQVKEKLLLLP
                     YIREELASLNQ"
     gene            complement(5232..6038)
                     /locus_tag="VVR18_001808"
     CDS             complement(5232..6038)
                     /locus_tag="VVR18_001808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000483014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033283.1"
                     /translation="MFNSSCALFIVSCETNQQVVNLLIQSMRQQISHMVSIYVSSDGP
                     LLITDPSVRVLIGQEEVFGDRVATALEQVTEERVIVFCDDFIVEKPAKIEELEELLSL
                     MEEDTSIASIALSQISGGNTPERIAEHYIRRTKYAPYKTTLQCAIWKKSSLIQFMKGS
                     PSPWEFEIYHNFKTYLTKEKFYALEDDMFQPIPYNRGKLIIRGKVVKPEKERLEELLG
                     YSLDLSDFPETESFVQGENLTVGYRLKRKIKLLEKEIIYRLKSKIKNKKK"
     gene            complement(6031..7116)
                     /locus_tag="VVR18_001809"
     CDS             complement(6031..7116)
                     /locus_tag="VVR18_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEU6033284.1"
                     /translation="MSKKKISYVTNNIAPFRVMLLDELAKHAEVTLFYVHEIEAGVKA
                     EYVKLRPVRTKLQSITELGLFQTFQMLKEMDMVFFDGYTGWEKMFLMSSMWLTRRQYA
                     ISVDGIINHSNISLKQRLLDFIKSVALSKAEFVLSTNTPTDAYIQQLAPKAKIKRHIF
                     STLSQDDFKNMIEVASDTVFTRYSIRKSEKNLLFVGQFINRKGVDELLAFMKEHEADT
                     SLQLIMVGGTREELSVFETEIPSNIHIIPFLEKTDILELMRVADVFVLPTREDIWGLV
                     IIEALSMGIPIVSTDRCNAALEFVRDGENGYLMQEVTAVELANKLKATFKLDAEHVAR
                     YDQKLMQDYNLEGSAKNIMDILEGSHV"
     gene            complement(7130..8011)
                     /locus_tag="VVR18_001810"
     CDS             complement(7130..8011)
                     /locus_tag="VVR18_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000623489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU6033285.1"
                     /translation="MISIIMPAYNEEKNIGAAIASIQQQTYTDFQLIIVNDGSTDDTA
                     AIVQEKIMGDERIVFLNPGKIGKVPAYNLASQYVKGDWIYFMGADDQLPLDAFEKWNK
                     EAQKWNPAEKVALRARMRMVSDSHKYDGLVLPKKNTVRNFSGPLTLLSKEMHRFILPI
                     PEAYPNEDIWWGLCIEYFGDRVSLIEDVVVYYRVHEGNSISRTSTFEPFNEKYHIRQI
                     IRRDFLERFSNHLTADQKTKLQRELKLEEARYKGNRLPILLMPGISAVHRLRLLFLSG
                     RRSYVLKVKLDRFFLGH"
     gene            complement(8008..9477)
                     /locus_tag="VVR18_001811"
     CDS             complement(8008..9477)
                     /locus_tag="VVR18_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004246375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligosaccharide flippase family protein"
                     /protein_id="HEU6033286.1"
                     /translation="MNILKQVSLKWNYVFNLANKLFSLTIPLIVTPYVTRVFSSDHFG
                     IYTYTNTVASYFVTFTLMGISMYGSKKISLKRHDEIAVNDEYASLLTVQLLNVGLATL
                     TYFLYVTFFVNNNQVIYWIQMLYVISAGFDMTWFLSGLERFREIAVRNIIVNVLSALM
                     IFFFVHTEADLAIYTLIKVGTIFISQIVIFLPVVRMQRFYLAGAEHIRRTYRGLLLLF
                     IPVLADTLFQTMDKIMLGIYASYTAVGLYYSSRMVTDIPQTVITSLNIILFPRITHLL
                     SQNKKVESNKLFYQSFILIIALSLATAFGVSAIARDFVGIFFGSSYGAVADYVPSLSL
                     YICLAAWSGTIRYQYLIPHSLERVYVVAIILGSGINLVLNSLLIPFLGVYGSILATII
                     SELVICVYQTYPIRKEIPLKGLLGYVIIFAGLSFLMYLSLGWLRLLLLGRLSTVLLLA
                     SEIIFGILVFTIATITYIYLGNPILWQAIKKYIESRKNV"
     gene            complement(9455..10660)
                     /locus_tag="VVR18_001812"
     CDS             complement(9455..10660)
                     /locus_tag="VVR18_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="HEU6033287.1"
                     /translation="MESRKKFVCFPNSSLRFYILQAAIALSILSQAPYIWKFSGIPTQ
                     LLIMPLWILLGVVSIFSRIDMERSFLFFLLTIGCLISTIALLDIVTGVSYVFNGLSQQ
                     LYLAVGILVLGYWNADVIVHYWKIITMTFLGACLLISVDIYFHYFQGHTFSNIDYVYR
                     AKNSAASIFLSAVILNLSLYNRKWALWRKVLLLASSGLLIYMCILMRSRAVLLAAAVL
                     PLVYIWFQETSLGHKIGRTLGVSTVVGAFLLNSAIYDFFINNLFLRVTSEYRPSSLTL
                     DYVSSNRFVYFEIFAKEISGHELTGIGYYYMDNFFLESFLNYGYIVGTAFVLIALSPM
                     IYALLQRSSSHRFRMLFLALAFSYTVNALFEGYAPFGPGAKSFILWLVFGCLLNTRIG
                     KVGEHSETS"
     gene            complement(10891..12117)
                     /locus_tag="VVR18_001813"
     CDS             complement(10891..12117)
                     /locus_tag="VVR18_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004248660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEU6033288.1"
                     /translation="MKILFVSQHYRPEPFRLSDICEDLVERGHEVTVLTGIPNYPEGK
                     TYADYRNNKNRRETIEGVTVFRSYTIPRGKSTLHRILNYFSFAISSSIGVLLGQYKAK
                     DGSEFDCIFVNQSSPVMMAWAAMAYKNKYKKPMFLYCMDVWPDSLTVGGVKQDGLIFK
                     LFKFISKKVYRASDYIFVTSPSFKNYFVNQFDITEQKITYLPQYAEDLFIPDESRVNK
                     ESVDLTFAGNIGKAQNLETILKAASLIEKNTDLPKKIQFHFVGDGTELLSMKALAHEL
                     ELKNVSFYGRRSLEEMPTFYKKSDAMLVSLIGDSIVSRTIPGKVQSYMAAGKPIIGAI
                     SGDTKTIVEEAKCGFVSPEQDVEQLAQNICKFSMLSTEEQRELGKQARCYYGKHFSKE
                     QFMTQLENYLREGFSS"
     gene            complement(12126..>12686)
                     /locus_tag="VVR18_001814"
     CDS             complement(12126..>12686)
                     /locus_tag="VVR18_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEU6033289.1"
                     /translation="SISLIVITLFCPFFILIAIAIKFDSKGPVIFKQKRFGIHKKTFY
                     VFKFRTMKVETPKNVATRDLQNPEQWITRVGTFLRKTSLDELPQLCNILVGDMSIVGP
                     RPALWNQFDLIEERDKYGANDILPGLTGWAQINGRDNLSIDMKAELDGYYVTHKSLLM
                     DIRCIVRTIPYVLKRKGIVEGSQKES"
BASE COUNT         4253 a         2633 c         1917 g         3883 t
ORIGIN      
        1 cttatcaagc gcaatgcctt tggttttcgg aactttgaaa acttcaaaaa acggattttc
       61 atcgctctga acatcaaaaa agaaaggacg aaatttgtcc tttctcaagc ttagcttttc
      121 ttcaacccac tacagttgac aaagagccct ttattctatc aaacatgaag cgcaaaaaca
      181 agccaaaaat ccgatagaat ggctatccct cgactatcaa gtaagacatt tccatcaaat
      241 acgttcaatt ttactcttgt tctactaaga attaatcatc tcgttttgat ttattaaaaa
      301 tatacaattc agcttttcct ccaaactatt ttatccacta tccctgtata gctctgtatt
      361 atcttaacaa ctttagtaga gacattttcc tcaacataat ctggaaccgg taatccaaaa
      421 tcctcatctt ctgccaagct aacagcagtt tcaactgctt gaagaagaga attttcatca
      481 atgcctgcca aaataaatcc tgccttatct aaggactcag gacgttctgt acttgtacga
      541 atacatacag caggaaaagg ataaccttga ctagtaaaga aactactttc ttccggtaaa
      601 gttcccgaat cagatactac aacaaatgca ttcatctgta aacaattata gtcatggaat
      661 cctagtggct catgctgaat cacacgttta tctagtttaa aaccgctctc ttgtagcctt
      721 ttctttgatc taggatggca agaatataag attggcatat tatacttttc agctaattga
      781 ttaattgctg taaagagaga aataaaattt ttatctgtat caatattttc ctcacggtga
      841 gctgaaagta agatataacc tccttttttc aatcccaaac gttcatggat atctgaagac
      901 tcaatggcag ataaattttt atgtaacact tctgccatag gagaacctgt tacatatgtg
      961 cgctctttag gtaaaccaca ctcatgtaaa tacttacgtg catgttcaga gtatgctaag
     1021 ttaacatctg aaataatatc aacaatccga cgattagtct cttccggcag gcactcatcc
     1081 ttacagcgat tgccagcctc catatgaaaa attggaatat gtaaacgctt ggcagcaata
     1141 gctgataaac aagaatttgt atcccctaaa atcaataaag catctggttt aatttgattc
     1201 atcaatttgt atgaagtatt aataatattc cctacagtag caccaagatc atctccaaca
     1261 gcatccatgt atacgtccgg agtgtctaac cctaaattat caaagaaaat accatttaaa
     1321 ttgtaatcat agttttgtcc agtatgtgcc aaaataacat caaaatactt tcgacattta
     1381 gtgataacac tacttagacg tataatctct ggacgtgttc ccacaataat caataactta
     1441 agtttgccat tatctttaaa gtgaatatca ctataatctg tcttaatttt catttatttc
     1501 tccacttgtt caaaaaaagt atctggatgt ctaggatcaa atgactcatt agcccacatg
     1561 acagtaacta gattttctgt atcagaaaga ttaataatat tatgtgcata gcccggtatc
     1621 atatgtattg cttcaatctt atcgcccgac acttcaaagt tcagaatagg atactcttga
     1681 ccgttttcat ccagccctat cctacgctct tgtattaaag cacgaccaga aacaaccatg
     1741 aaaaattccc acttagaatg atgccaatgt tgccctttgg taatgccagg tttagaaata
     1801 ttaacagaaa attgaccctt attttctgtt tttaataatt ccgtaaaact acctcgttca
     1861 tctatattca tttttagagg aaacttaaac ttatctactg gtaaataaga taggtaggta
     1921 gaatacaatt tctttttaaa cgatccttga ggaatttcag gcataactaa actattaggc
     1981 tgttttttaa atgtttctaa tagagagaca atctctccta aggttgcacg atgagtcgtt
     2041 ggtacgtagc agtagtttcc tgatgggcta ggtaagattt gtaatccatc tagattacaa
     2101 cgatgaggat ttccttccaa tgcagttaga cactcttgta tcaaatcatc aatatacagc
     2161 aactccaatt ctacacttgg atcatttact tgaataggta aatcgtgagc tagattatga
     2221 cagaaagttg ctacagcaga attgtagtta ggacggcacc acttcccata aagattcggg
     2281 aaacggtaaa ctaagacagg tgctcccgtt ttctttccat attcaaagaa gagttcttcc
     2341 cctactagct tagattgtcc atatatagag tttgaaaatc ggccttctaa actagcttga
     2401 gtagaacttg agagtagaac aggacaagtg ttttcatact tttctaaaat ctccaataat
     2461 ctacttgaaa aaccgtaatt tccctccatg aattcatcag gattctgtgg acgattgaca
     2521 ccagctaaat ggaatacgaa atcggccttc ttacaatatt catctaataa aatcggatct
     2581 gtatcacgat catactgaaa aatctctcca atctctaaat taggacgagt cctatctcgt
     2641 ccatctttca aagcttccag agtacagata agattttttc ctacaaatcc tttagaacca
     2701 gtcactaaaa tttttaatgg catatttttc cctccatata cttaatctcg ctgaaaaata
     2761 tctcttgtat aaactttttc tagcacatca tataaagatt tttccatccg attggcaaca
     2821 atcacttgac tgctagactt aaaaacttcc aaatcattaa ccacctgatt accaaagaaa
     2881 aagctatgat cctccaaagt tggttcatag ataattactt ctacaccttt ggcctttaaa
     2941 cattttataa caccttggat tgatgattga cggaaattat ccgaaccact cttcatagtt
     3001 aagcggtaaa cacctactat gattgtttga ttaccgtctg aaagctccaa cgcatttttc
     3061 aaaatacgat cggcaataaa atacttgcga gtacggttac tttctacaat agctgtcatc
     3121 atattttgtg gtacatcatg ataattcgcc agcaactgct tactatcttt gggaagacaa
     3181 taacctccat aaccaaatga cggattgtta taatggctac caattcgtgg atctaaccct
     3241 actccgtcaa tgatggattt agtgtccaat ccctttatct ccgcataggt atccaattcg
     3301 ttaaagtaag aaacccgcaa agccaaatag gtgttggcaa atagtttgac tgcttctgcc
     3361 tctgttacac ccataattaa ggtctcaaca tcaggtttaa gtgaaccttc ctgcaaaaga
     3421 gttgcaaacc gctcagcctg aactacctgc tccgtatctc tcaaatctgc tccaacgatg
     3481 attcgactag gatagagatt atcataaagt gctttagact cccgtaaaaa ttcaggacta
     3541 aagagaatct taaattgccc aaaacgtgtt cggagacttt ctgtatatcc cacaggaatt
     3601 gtggatttta tgacaattgt tgccttcaaa ttaaccgcaa taatctgctc aataactgct
     3661 tccacaacag atgtatcaaa ataatttttt ttactgtcat agttagttgg gacagcaatt
     3721 atgacaaagt cagcatctcg ataagcttca ttaccatcta atgttgcaac taagtctaat
     3781 tccttttcca ctaaataagt ttcaatatca tcatccttaa tgggagattg gcgacgattg
     3841 ataagctcta ctttttcagg aataacatct accgctataa ccttatgata ttgcgctaat
     3901 agaattgcaa tagataaacc cacataacct gtccctgcta ctgctatttt cataggatac
     3961 ctcactgatt taaagatgct aattcttccc taatataggg caaaagtaag agtttttcct
     4021 taacctgctc gacattccag agttctgtat tactactgtt aaactctatt aagggattgc
     4081 gtttggcatc cccttcgttg aaatacttat catagttaag atctcgatta tcgctaggca
     4141 cacgataaaa gccgcctaaa tcaatggcat tcgtacattc ttcagtagtc aacaacgttt
     4201 catacatctt ttcaccgtgg cgaatcccga ttactttaat atcttgatta ggtgcaaaaa
     4261 gttccgtaac agcttgcgcc aacacttcaa tggtacatgc tggtgctttc tgtactagga
     4321 tatctcctgt ttttcctttt tcaaaagcaa acagaactag gtctaccgct tcttctaagg
     4381 acataataaa acgagtcata ctaggttccg taatcgttat aggattccct tgctttattt
     4441 gatcaatcca taggggaatc acagaaccac gactacatag aacattgccg tagcgagtta
     4501 cacagacttt tgtctgatct tcttctaccg tccttgactt agcaacagca atcttttcca
     4561 tcatagcctt agaggttccc atcgcattaa caggataggc tgccttatct gtagaaaggc
     4621 agatgacttg ttttactcca gcttctatag ctgcagtgag aatattttca gttcctagaa
     4681 cgttagtttt gactgcttcc acagggaaaa attcacaaga agggacttgt tttaatgcag
     4741 cagcatgaaa tacgtaatcc acaccgatca tagcattttt aacagaagct aaatcacgca
     4801 catctcctaa gtaaaaacgt atcttatcag ctacttctgg catttttgct tgaaattcat
     4861 gacgcatatc atcctgtttc ttctcatctc ttgaaaagat acgtacctcc gaaatatctg
     4921 ttcccaaaaa tcgtttgaga actgcattcc cgaatgaacc tgtcccccct gtaataagga
     4981 gagttttctt tgtaaacata gttattactc ctatctataa tgatgttcaa cataatgctt
     5041 tttaaataaa tttaaagctt aacaacatga aaaataacgc actacaatat ttttctgact
     5101 gataatattg gtgagaattt caacatacac cttatccaaa agaaaagcta tatttttaaa
     5161 ggtgtagaaa taaagataac tcaatcttta aatcttttgc atccaccaaa tattataaac
     5221 tttctttttc actatttttt cttattcttt attttagatt tcaaacgata aataatttct
     5281 ttttctaaca atttaatctt tctcttcaac cgatagccta cagtaagatt ttccccctgg
     5341 acaaaagact ccgtttctgg gaaatccgat aaatctaatg aataacccaa aagttcctcc
     5401 aaacgttctt tttcaggttt aacaacttta cctcgaataa tcaactttcc tctattataa
     5461 gggataggtt ggaacatatc atcctctaaa gcataaaatt tctctttcgt caggtaagtt
     5521 ttaaagttat gataaatctc aaattcccaa ggagagggac tccccttcat gaattgaatc
     5581 aaactagact tcttccaaat agcgcattga agagttgtct tatagggggc atatttcgtg
     5641 cgtcttatat aatgctcagc aatacgctca ggtgtattcc ctccagatat ttgtgacagg
     5701 gcaatactag caatacttgt atcctcttcc attagagaca gtagttcttc taattcttca
     5761 attttagctg gtttttctac gataaagtca tcacaaaaaa caatgactcg ctcttcagta
     5821 acttgttcca aagcagttgc aacacgatct ccaaaaactt cttcctgacc aatcaaaacc
     5881 cttacgctag gatccgtgat taacaatggg ccatctgatg atacataaat ggataccata
     5941 tgagaaatct gctgacgcat ggactggatg aggagattga ctacctgctg attagtctcg
     6001 caactaacaa taaataaagc acaagatgaa ttaaacatga cttccctcca agatgtccat
     6061 aatatttttt gctgaacctt ccagattata gtcttgcatc agtttttgat catagcgagc
     6121 aacatgctca gcatctagtt taaaggtagc cttaagcttg ttagccaatt ctaccgcagt
     6181 cacttcctgc atcagataac cattttcgcc atccctaaca aactccaagg ctgcgttaca
     6241 acgatccgta gaaacaatag gaatgcccat tgatagcgcc tctataataa ccagtcccca
     6301 aatatcttct cgagtgggca aaacaaagac atctgccacc cgcatcaact ctaggatatc
     6361 agttttttct agaaaaggaa ttatatgtat attagaagga atctctgttt caaaaactga
     6421 caattcttct cttgtacctc cgaccataat taactgcaac gaagtatcag cttcgtgctc
     6481 tttcataaaa gccaaaagct catcgactcc ttttctattg ataaactgtc ccacaaaaag
     6541 cagatttttc tcagattttc gaatactata tcttgtgaaa accgtatccg aggcaacctc
     6601 tatcatgttt ttgaaatcat cttgtgaaag agttgaaaat atgtgtcgtt taatctttgc
     6661 cttgggagct aattgctgta tataagcatc tgttggggta ttggtgctaa gcacaaactc
     6721 cgctttgctt agagcaacag acttaataaa atccaacagt ctctgcttaa gtgagatatt
     6781 actatgattt attataccat caacagaaat agcgtactgc cgtcttgtta gccacatact
     6841 gctcatcaag aacatctttt cccacccagt atagccatca aagaagacca tatccatctc
     6901 tttcaacatt tgaaacgtct gaaataaacc tagttctgtg attgattgga gcttggtacg
     6961 aacaggtcgt agcttgacat actcagcctt tacccccgcc tcaatttcgt gcacataaaa
     7021 aagagtcact tctgcatgct tggctaactc atctaataac ataaccctaa aaggagcaat
     7081 attatttgta acataagaaa tttttttctt tgacatctct tccttctttc taatgtccta
     7141 agaaaaagcg atccaatttg actttaagta catatgaacg cctacccgat aaaaaaagta
     7201 atcgaagtct gtgtactgca gaaatacctg gcatcagaag aattggcaat ctatttcctt
     7261 tatagcgtgc ttcttctagt ttcaattcac gctgaagttt agtcttctgg tctgctgtta
     7321 agtgattgct aaatctctct aaaaaatcac gacggataat ctgacggata tgatatttct
     7381 cgttaaaagg ttcaaaagtt gaggttcggg atatagaatt cccctcatga acacgataat
     7441 aaaccacaac atcctcaatc aacgaaacac gatctccgaa atactcaata catagccccc
     7501 accaaatatc ttcgttcgga taggcctcag gtataggaag gataaaacgg tgcatctctt
     7561 ttgaaagcaa ggtaagaggt ccactaaaat tgcgaactgt atttttcttt ggtaatacca
     7621 atccatcata cttgtgagag tcagaaacca tccgcatgcg agctcttaaa gccacctttt
     7681 cagcaggatt ccacttttga gcctccttgt tccacttttc aaaggcatcc aatggcaact
     7741 ggtcatccgc tcccataaaa tatatccagt ctccttttac atactgtgaa gccaagttat
     7801 aagctggtac cttgccaatc tttccaggat tcaaaaagac aattcgctca tctcccatga
     7861 ttttttcctg tacaatagct gccgtatcat ctgtagatcc atcattgacg ataatcaact
     7921 gaaagtccgt ataggtttgc tgttgaatac tggcaatagc tgctccgata tttttttctt
     7981 cattataagc tggcataatg atagagatca tacgtttttc ctactttcta tatatttttt
     8041 aatagcttgc cataaaattg ggttacctag ataaatatag gttatagttg cgatagtaaa
     8101 aacaaggata ccaaatatta tttcacttgc caatagcaat actgtggata ggcggcctag
     8161 caataacaat cgtagccaac caagagatag atacataaga aaagacaagc ctgcaaaaat
     8221 gatcacatat cctaacaatc ctttaagagg aatttccttt cgaataggat atgtctggta
     8281 aacacaaatc actaattctg atataatagt agctaaaatg gaaccgtata ctcccaaaaa
     8341 aggaattaag agagagttta aaactagatt gatcccactt cccaaaataa tcgctactac
     8401 atagactctc tcaagtgaat gaggaatcag atattggtaa cgtatcgttc cactccaggc
     8461 agcaaggcag atatagagcg ataaactagg cacataatct gctaccgcac catatgaaga
     8521 tccaaaaaaa atacctacaa aatccctagc aatagcacta actccaaaag ctgtagctag
     8581 agataaagca ataattaaga taaaagactg ataaaaaagt ttattagatt caactttttt
     8641 attctgactt aaaagatgtg ttattcgtgg aaataagatt atattgagag aagtaatgac
     8701 agtttgcggg atgtcagtaa ccatcctact tgagtaatac aaacccacag cagtatagga
     8761 tgcatagata cctagcatga tcttatccat agtttgaaaa agggtgtctg ccaaaacagg
     8821 gataaacaac aaaagcaagc ctcgataggt acgtcgaata tgttcagctc ctgcaagata
     8881 aaaccgttgc atccgaacaa ctggtaaaaa aataacaatc tgactgataa aaatcgtccc
     8941 tacctttatt aaggtataga tagccaaatc agcctccgta tgcacaaaga aaaaaatcat
     9001 gagggctgat aagacattta caatgatatt tcgaacagca atttcacgaa aacgttccaa
     9061 tcctgataaa aaccaagtca tatcaaaacc agcagaaatc acatacaaca tctggatcca
     9121 ataaataact tgattattat tgacaaaaaa ggtcacatag agaaagtaag ttaacgtggc
     9181 tagacctaca ttaagcagct ggacagtcag taaggaagca tattcatcat tgactgctat
     9241 ctcatcatgt cttttaagag aaattttctt acttccatac atacttatcc ccatcaatgt
     9301 aaaggtaaca aagtaagaag caactgtatt ggtataagta taaatcccaa aatgatctga
     9361 agaaaagact cgagtgacat agggagtaac aataagtgga atagttagag aaaatagttt
     9421 attggcaaga ttaaacacat agttccactt tagactaact tgtttcagaa tgttcaccaa
     9481 cctttccaat tcgtgtattc agaaggcaac caaaaactaa ccaaagaata aaactcttgg
     9541 caccaggacc aaatggcgcg taaccttcaa ataaggcatt gacagtataa gaaaaagcaa
     9601 gggctaaaaa aagcatgcgg aaacgatgag aagaagaacg ttgcaagagg gcataaatca
     9661 tgggagacaa ggctattaaa acaaaagcag tccctactat ataaccataa ttgagaaaac
     9721 tctctagaaa aaaattatcc atataataat aaccaatccc tgttaattca tgtcctgaaa
     9781 tttctttagc aaagatctca aaatacacaa aacggttgga ggaaacgtag tccaaagtca
     9841 gactagatgg tcgatattca gatgtgaccc ttaaaaatag attattgata aaaaaatcat
     9901 aaatagctga attgagcaaa aacgcaccta ctactgttga aactcctaat gtccgtccaa
     9961 tcttatgccc caaagacgtc tcctgaaacc atatataaac tagcggaagt actgcagctg
    10021 ctaacagaac tgctcgtgac cgcataagga tgcacatgta aatcagcaat ccgctactag
    10081 ctaataacaa tacttttctc cacagtgccc acttgcgatt atatagagac aagttgagaa
    10141 taactgccga taaaaagata gatgccgctg aattcttagc tcgataaaca taatcaatat
    10201 ttgaaaaagt atgtccttga aagtagtgaa aataaatatc cactgaaatc agcaaacatg
    10261 ctcccaaaaa agtcatggtg atgattttcc aataatgaac aatcacatca gcattccagt
    10321 agcctaaaac tagaattccc acagccaaat agagttgctg agacaaacca ttaaagacat
    10381 aagatactcc cgtaactata tctaacaaag caatagtgct aattaaacaa cctattgtta
    10441 ataaaaaaaa taggaatgat cgttccatgt caattctaga aaaaatagac actactccca
    10501 acaggatcca caaaggcata atcagaagtt gtgtaggtat cccactaaac ttccagatat
    10561 agggagcctg cgataaaata gataaggcaa tcgctgcctg caaaatataa aaacgcaaac
    10621 tactattggg aaaacaaaca aatttctttc gggattccat tcctcctcct tactatcgtc
    10681 aacatgtcag tacctatgta cttttatttg gaattacagc tattatacaa tagttaataa
    10741 gtcattaaga acttattatc ttacagaaaa tacttaaatt tacttactaa actttcaaat
    10801 cctataaatt gaaacgccaa atctcagcaa atttctttaa caaagtatct atactcctaa
    10861 taccacaaac agtattaatc attaaaattc tcatgaggaa aatccctctc tcaaataatt
    10921 ttctaactgt gtcataaact gctctttaga aaagtgcttc ccatagtaac aacgagcttg
    10981 ctttcctaac tctctttgtt cttccgtaga caacatacta aatttacaaa tattttgtgc
    11041 caattgttcc acatcttgtt caggactgac aaaaccacac tttgcttctt ctacaattgt
    11101 tttagtatct cctgaaattg cacctataat tggtttccct gccgccatgt aagattgtac
    11161 cttcccaggt atagtacgag aaactatcga gtctcctatt aaagaaacta acatagcatc
    11221 tgatttttta tagaaggtag gcatttcttc caaagaacgt cttccataga aggaaacatt
    11281 ctttaactcc aattcatgag ctaatgcttt catacttagc aattccgtac catctccaac
    11341 aaaatgaaat tgaattttct tgggtagatc ggtattcttc tctatcaaac tggcagcttt
    11401 caaaatagtt tccaaatttt gtgctttgcc aatattacca gcaaaagtta ggtcaacact
    11461 ttctttatta actctagatt catcagggat aaaaagatct tctgcatatt gtggcaaata
    11521 agtaatcttt tgttctgtta tgtcaaattg gttcacaaaa taattcttaa atgatggact
    11581 agtaacaaat atataatcac tagctcgata aacttttttc gatataaatt taaacaactt
    11641 gaaaatcaag ccatcttgtt tcactccacc tacagttaaa ctatctggcc aaacatccat
    11701 acaatacaga aacataggtt tcttatattt atttttataa gccatagcag cccatgccat
    11761 cataactgga gacgattgat ttacaaaaat acaatcaaat tctgatccat cttttgcttt
    11821 atactgtccc agtagaaccc ctatcgagga actgatagca aaactaaaat aatttaatat
    11881 cctatgtaaa gtactttttc cccttggaat tgtataggaa cgaaaaacag taactccttc
    11941 tatagtctct cgtctatttt tgttattccg ataatccgca tatgttttac cttcaggata
    12001 attaggaatt cctgtcaaaa cagtaacttc atgacctctc tcaacaagat cctcacaaat
    12061 atctgataat ctaaaaggtt ctggtctata atgttgacta acaaataaaa ttttcatcgt
    12121 acaacttaac tctctttttg acttccctct acaattcctt tgcgtttcag cacataaggt
    12181 attgttctta ctatacatct aatgtccatt agcaacgatt tatgtgtcac atagtatcca
    12241 tccaattcag ctttcatatc tattgataga ttatcacgac cattgatttg tgcccaacct
    12301 gttaaaccag gtaaaatatc atttgctcca tatttgtctc tttcttcaat caaatcaaat
    12361 tgattccaaa gggcaggtct tggtcctaca atactcatat caccaacaag aatattacat
    12421 aattgaggca attcatctag agatgttttc cttaagaaag ttcccactct agtgatccac
    12481 tgctctggat tttgtaaatc tcgagttgcc acattttttg gtgtctccac tttcatagtc
    12541 cgaaatttaa aaacataaaa agtttttttg tgaattccaa aacgtttttg tttaaatatt
    12601 acaggtcctt ttgaatcaaa cttaatcgca attgcaatta ggataaaaaa tggacaaaat
    12661 aacgttataa ctattaaaga tataga
//
LOCUS       DAVHSO010000062        12063 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.063, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000062 DAVHSO010000000
VERSION     DAVHSO010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12063)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12063)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12063
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.063"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            260..913
                     /locus_tag="VVR18_001815"
     CDS             260..913
                     /locus_tag="VVR18_001815"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HEU6033290.1"
                     /translation="MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGTIYPPKEKVFQ
                     ALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKK
                     SHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
                     AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR"
     gene            923..1387
                     /locus_tag="VVR18_001816"
     CDS             923..1387
                     /locus_tag="VVR18_001816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003012002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEU6033291.1"
                     /translation="MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGE
                     TPQECAAREILEETGLKAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGT
                     LEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE"
     gene            1400..2668
                     /locus_tag="VVR18_001817"
     CDS             1400..2668
                     /locus_tag="VVR18_001817"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HEU6033292.1"
                     /translation="MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETI
                     DATGLVVAPGLVDIHVHFREPGQTHKEDIHTGTLAAAAGGFTTVVMMANTSPTISDVE
                     TLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
                     KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMI
                     AYATKAHVHIQHLSKEESVKVVEFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMN
                     PPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLG
                     LTYLVEAGELSLMELLEKMTYNPAKLYNFKAGYLAENGPADITIFDAKADRLVDSHFA
                     SKAANSPFIGETLKGQVKYTICKGQIVYQA"
     gene            2682..2942
                     /locus_tag="VVR18_001818"
     CDS             2682..2942
                     /locus_tag="VVR18_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033293.1"
                     /translation="MNYFRKRRERQAKSNSGIYCPAANRSKIQYETKEKADHAVQYDN
                     GGLVRSYYCRTCACWHTTSKSNKPPLSLKNYGLKLFGLDKSE"
     gene            2953..4314
                     /gene="pdrM"
                     /locus_tag="VVR18_001819"
     CDS             2953..4314
                     /gene="pdrM"
                     /locus_tag="VVR18_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-coupled multidrug efflux MATE transporter
                     PdrM"
                     /protein_id="HEU6033294.1"
                     /translation="MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNT
                     MDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLS
                     VVLLGMVLFLAPTILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLT
                     KLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQ
                     EKLKALHLEKRIPLNMDKIKEGVRLGLPIGGTVFAEVAVFSVVGLIMAKFSSLIIASH
                     QSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTF
                     LYIFRGNVASLYGNDPKFIDLTARFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYL
                     GLLGYWGVAIPVATLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAK
                     SKR"
     gene            4468..5436
                     /locus_tag="VVR18_001820"
     CDS             4468..5436
                     /locus_tag="VVR18_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HEU6033295.1"
                     /translation="MSTLDKNLLLEMFRKMEEIRRMDLKIAQLVKKGKVPGMTHFSVG
                     EEAANVGAMLALNPDDLITSNHRGHGQAIAKGIDLNGMMAEILGKYTGTCKGKGGSMH
                     IADLDAGNLGANGIVGGGMGIAVGAALSQQMQNTGKIVVCFFGDGATNEGVFHEAVNM
                     ASIWNLPVIFYCINNGYGISADIKKMTNIEHIHQRSAAYGIPGMFIEDGNNVIDVYEG
                     FQKAVDHVRSGNGPVLIESVTYRWLGHSSSDPGKYRTREEVELWKQKDPIENLRNYLI
                     ENNIASAEELEKIQAQVKEAVEASVKFAEESPFPPLESAFEDIYTD"
     gene            5452..6444
                     /locus_tag="VVR18_001821"
     CDS             5452..6444
                     /locus_tag="VVR18_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000448722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HEU6033296.1"
                     /translation="METKTMSFRDTIILAMSEEMRRDENVFLMGEDVGVFGGDFGTSV
                     GMLEEFGPERVRDCPISEAAISGAAAGAAMTGLRPIVDMTFMDFSVIAMDNIVNQAAK
                     TRYMFGGKGQVPMTVRCAAGNGVGSAAQHSQSLESWFTHIPGLKVVAPGTPADMKGLL
                     KSSIRDNNPVIILEYKSEFNQKGEVPVDPDYTIPLGVGEIKRQGTDVTVVTYGKMLRR
                     VVQAAEELAEEGISVEIVDPRTLVPLDKDIIINSVKKTGKVVLVNDAHKTSGYIGEIS
                     AIISESEAFDYLDAPIRRCAGEDVPMPYAQNLENAMIPTVESIKDAIRKTYNKE"
     gene            6662..7705
                     /locus_tag="VVR18_001822"
     CDS             6662..7705
                     /locus_tag="VVR18_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /protein_id="HEU6033297.1"
                     /translation="MADDKLRATPAARKLADDLGINLYDVSGSGANGRVHKEDVETYK
                     DTNVVRISPLAKRIALEHNIAWQEIQGTGHRGKIMKKDVLALLPENIENDSIKSPAQI
                     EKVEEVPDNVTPYGEIERIPMTPMRKVIAQRMVESYLTAPTFTLNYEVDMTEMLALRK
                     KVLEPIMEATGKKTTVTDLLSLAVVKTLMKHPYINASLTEDGKTIITHNYVNLAMAVG
                     MDNGLMTPVVYNAEKMSLSELVVAFKDVIGRTLDGKLAPSELQNSTFTISNLGMFGVQ
                     SFGPIINQPNSAILGVSSTIEKPVVVNGEIVIRPIMSLGLTIDHRVVDGMAGAKFMKD
                     LKELIETPISMLI"
     gene            7769..9454
                     /gene="lpdA"
                     /locus_tag="VVR18_001823"
     CDS             7769..9454
                     /gene="lpdA"
                     /locus_tag="VVR18_001823"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HEU6033298.1"
                     /translation="MPKAGVDMTEGQIVQWNKKVGEFVKEGEILLEIMTDKVSMELEA
                     EEDGYLIAILKGDGETVPVTEVIGYLGEERENIPTAGAASPEASPVPVASTSNDDGKS
                     DDAFDIVVIGGGPAGYVAAIKAAQLGGKVALVEKSELGGTCLNRGCIPTKTYLHNAEI
                     IENIGHAANRGIVIENPNFTVDMEKLLETKSKVVNTLVGGVAGLLRSYGVTVHKGIGT
                     ITKDKNVLVNGSELLETKKIILAGGSKVSKINVPGMESSLVMTSDDILEMNEVPESLV
                     IIGGGVVGIELGQAFMTFGSKVTVIEMMDRIVPAMDAEVSKNLRLILERKGMTILTGT
                     KLQEIIEENGQLRIKVEGKDDIIASKALLSIGRMPDLEGIGEVEFELDRGCIKVNEYM
                     ETSVPGIYAPGDINGTKMLAHAAFRMGEVSAENALKGNHAVAKLNLTPAAIYTLPEVA
                     AVGLTEEQAREKYDVAIGKFNFAANGRAIASDAAQGFVKVIADKKYGEILGVHIIGPA
                     AAELINEASSIIEMEITVEEMLKTIHGHPTYSEVMYEAFADVLGMAIHSPKKK"
     gene            9518..10507
                     /locus_tag="VVR18_001824"
     CDS             9518..10507
                     /locus_tag="VVR18_001824"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HEU6033299.1"
                     /translation="MKYIINHSNDTAFNIALEEYAFKHLLDEDQIFLLWINKPSIIVG
                     RHQNTIEEINRDYVRENGIEVVRRISGGGAVYHDLNNLNYTIISKEDENKAFDFKSFS
                     TPVINTLAQLGVKAEFTGRNDLEIDGKKFCGNAQAYINGRIMHHGCLLFDVDLSVLAN
                     ALKVSKDKFESKGVKSVRARVTNIINELPKKITVEKFRDLLLEYMKKEYPEMTEYVFS
                     EEELAEINHIKDTKFGTWDWNYGKSPEFNVRRGTKFTSGKVEVFANVTESKIQDIKIY
                     GDFFGIEDVAAVEDVLRGVKYEREDVLKALKTIDITRYFAGISREEIAEAVVG"
     gene            complement(10580..11650)
                     /gene="xerS"
                     /locus_tag="VVR18_001825"
     CDS             complement(10580..11650)
                     /gene="xerS"
                     /locus_tag="VVR18_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000817875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine recombinase XerS"
                     /protein_id="HEU6033300.1"
                     /translation="MKREILLERIDKLKQLMPWYVLEYYQSKLAVPYSFTTLYEYLKE
                     YDRFFSWVLESGISNADKISDIPLSVLENMSKKDMESFILYLRERPLLNANTTKQGVS
                     QTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLAARAENIKQK
                     LFLGDETEGFLTYIDQEHPQQLSNRALSSFNKNKERDLAIIALLLASGVRLSEAVNLD
                     LRDLNLKMMVIDVTRKGGKRDSVNVAAFAKPYLENYLAIRNQRYKTEKTDTALFLTLY
                     RGVPNRIDASSVEKMVAKYSEDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHAS
                     TQVTDLYTHIVSDEQKNALDSL"
BASE COUNT         3594 a         2246 c         2683 g         3540 t
ORIGIN      
        1 tttctaaaga aactcctttt tctgaaatgg attttaatat gtttaaaaat atttcagaaa
       61 agataatctt cgaaagaggt agtaaaatgc ttaatgattt aaaaagtaat tataaaaaat
      121 agccagtctt tataaactgt attcacgtat tcaaatcgta tatatagtcg atttattaaa
      181 tctttagata aactgtaaaa agtggtttcc atagccactt tttgctataa tagaggcagt
      241 aaaaatgaag gagttggcta tggaacactc gtcttggcac gctttgatta aggcgcaatt
      301 acctgagggt tatttcggga aaatcaatca gtttatggag caggtctatt ctcaggggac
      361 tatttatcca cccaaggaaa aggtttttca ggctctcttg acaacactgc ttgaagaagt
      421 taaggtggta attctagggc aagaccccta ccacggacca ggtcaagcgc agggcttgag
      481 tttttctgta cctgactcta tcccagctcc accatccttg caaaatatct tgaaagaatt
      541 gtcagatgat atcggagtta agaaatctca tgatttgaca gcttgggctg agcaaggagt
      601 cttgcttctt aatgcttgtt tgactgttcc tgctggacag gccaatggtc atgctggtca
      661 aatctgggag ccttttactg atgctgtgat tcaggtggtc aatcatctag atagaccagt
      721 cgtttttgta ctctggggag cttatgcacg taagaagaag gcattagtta ccaatcctca
      781 tcacttgatt atcgaatcag cccatccaag tcctttgtcg gtttatagag gattttgggg
      841 ttccaagccc ttttccaagg ccaatgcatt cttaaaagag acaggacaag agccaatcga
      901 ttggcttaga taaggagaaa atatgcctca gttagcgacg atttgctaca ttgataatgg
      961 gaaagaactg ctcatgctcc atcgtaataa gaaacccaat gatgtccatg aagggaaatg
     1021 gattggtgtg ggtggtaagc tagagagagg agagacgccc caggaatgcg cggcgcgtga
     1081 aatccttgaa gaaacagggc tcaaagccaa gccagttcta aaaggtgtca tcacttttcc
     1141 tgaatttaca ccagatttag actggtacac ctatgttttt aaggtgacgg agtttgaggg
     1201 cgacttgatt gactgcaatg aggggacgct agaatgggtt ccctatgacg aggttttgag
     1261 caagccgact tgggaaggtg accacacctt tgttgagtgg cttttagagg ataaaccctt
     1321 cttttcagct aagtttgttt atgatgggga taaattgttg gatacccaag ttgatttcta
     1381 tgaataaagg agaaagcaga tgctactaat caaaaatggt cgtgtaatgg atcctaagtc
     1441 tggtttggat caagtttgtg atgtcttagt tcaagatggg aaaattatca aaattgcgcc
     1501 tgagatcacg gaagaaggag cagaaacgat tgatgctact ggtcttgtgg ttgctcctgg
     1561 tttggtcgat attcatgtgc atttccgtga acctggtcaa acacataaag aagacattca
     1621 tactggtacc ctggcagccg ctgcaggtgg ttttactact gtcgtcatga tggctaatac
     1681 cagtccaacc atttcagacg tggagacttt gcaagcagtt ctccagtcag ctgccaaaga
     1741 gaagattaat gtcaagacag ttgcgaccat tactaaaaac tttaatggta aaaacttgac
     1801 tgactttaag gcgctcttag aagctggtgc ggttggtttc tctgatgacg gtattccgct
     1861 tgagagcagt aagattgtca aggaagccat ggaggaagcc aaaaaactca atacctttat
     1921 cagccttcat gaggaagatc caggtttgaa cggtgttctt ggctttaatg aaaatattgc
     1981 tagagaacat ttccatatct gcggtgctac tggagtggct gagtacgcta tgatggcgcg
     2041 tgatgtcatg attgcctatg caactaaagc ccatgttcac atccagcatt tgtctaagga
     2101 agaaagtgtt aaagtagtgg agtttgctca ggggttaggt gcagaagtca cagcagaagt
     2161 agcaccacag catttctcta agacagaagc acttctttta acacaaggta gcaatgctaa
     2221 gatgaatcca ccgcttcgtt tggaatcaga ccgtcgtgcc gttatcgaag gtctcaaatc
     2281 aggtgtcatc acagttattg cgactgacca cgcgcctcat catgtagatg aaaaaaatgt
     2341 tgaagatatt accaaagcgc catctggtat gactggctta gaaacatccc tgtctctcgg
     2401 cttgacctat ttggtagaag ctggtgagtt gagcttgatg gaattacttg aaaaaatgac
     2461 atacaaccca gccaagcttt acaactttaa agcaggttac ttggctgaga atggtccagc
     2521 agatatcact atttttgatg ccaaggctga ccgccttgtg gactcccatt ttgcttccaa
     2581 agcagctaat tcaccattca tcggtgaaac cttaaaaggg caggttaaat ataccatctg
     2641 taagggacaa atcgtctatc aagcttgata ggagttagaa tatgaattat tttcgaaaac
     2701 gtagggagag acaagcgaaa tctaatagtg gaatttactg tcccgcagct aatcgttcca
     2761 aaattcaata tgaaactaaa gaaaaagctg accatgcggt tcaatatgat aacggaggtt
     2821 tggttagaag ctattattgt cgtacatgtg cgtgttggca tactacttca aaatctaata
     2881 aacctccgct aagtttgaaa aactatggtc tgaaactctt tggtttagat aaatcagaat
     2941 agaaagagaa gtatgtataa gacaaagtgt ttacgagaga agttggtatt atttttaaaa
     3001 attttcttcc caatcctgat ttaccaattt gccaattatt ctgcctcttt tgttgatact
     3061 gcaatgacag gtcaatacaa cactatggac ttggctggtg tatctatggc aaccagtatc
     3121 tggaatcctt tctttacatt tctaacaggg attgtgtcag ccttggtgcc tatcattggt
     3181 caccatcttg gtcgaggaaa aaaggaagaa gttgcgtctg atttttacca atttatttat
     3241 ttggccttgg gcctatctgt ggtcttgctg gggatggtac ttttcttggc accaacaatc
     3301 ttgaatcata ttgggttaga agcagcagta gcggcagtag cggttcgcta tctttggttt
     3361 ttatctatcg ggattatccc cttgttgctc tttagcgtca ttcgttcctt gctggattcg
     3421 ctgggcttga ccaaactgtc catgtacctc atgcttttgt tactccctct caatagcgga
     3481 tttaactatc tcttgattta cggtgccttt ggtgttccag aactgggagg ggctggtgct
     3541 ggtttaggaa catccttggc ctactgggtc ttgcttggga tttctgttct ggttttattt
     3601 aaacaggaga agctcaaagc cttacacctt gagaaacgaa ttccacttaa tatggataaa
     3661 attaaggaag gagttcgttt aggtctgcct attgggggaa ctgtcttcgc ggaagtggct
     3721 gtcttttcag tggttggctt gattatggct aagttttcgt ccttgattat agctagtcac
     3781 cagtcagcta tgaacttttc aagtcttatg tacgcctttc ctatgagtat ctcatcggct
     3841 atggctattg tcgtttccta tgaagtggga gccaagcgat ttgatgatgc gaaaacctat
     3901 attggtctag gaagatggac tgccctcatt tttgcggcct tcaccttaac cttcctttac
     3961 atttttaggg gaaatgtggc cagtctttat ggtaacgacc caaaatttat cgatttgaca
     4021 gcgcgttttt taacttatag tcttttcttc cagttagcag atacctttgc ggcgccgctt
     4081 cagggaattt tgcgggggta taaggataca gttattcctt tttaccttgg tttgcttggt
     4141 tattggggcg tagcaatccc tgtggctacg ctatttgatt ccctaacaga ttttggagct
     4201 tattcttact ggatcggctt gattattagt ttgattgtga gcggggcgct ctaccgttgg
     4261 cgtttaactg tgattatgaa gagatttgaa tctttagcaa aatccaaacg ctaaaaagtt
     4321 tgtgaaaaaa tattcttgac aagaaaatcc cttgttttca cggggttttc ttttttattt
     4381 tgtgaaattt cttttagaaa aactttgaca gtatttgcca aaagcggtaa aatagtaagg
     4441 taagaagaaa gttagaaagg caagaagatg tcaactttag ataaaaatct tttgctagaa
     4501 atgttccgta agatggaaga aatccgtcgc atggacttaa aaattgcaca attagtaaag
     4561 aaagggaaag tgccaggaat gacgcacttt tctgttggtg aagaggcagc taacgtgggg
     4621 gctatgttag ctctcaatcc agatgatctg attacctcaa accaccgtgg acacgggcaa
     4681 gctattgcta aagggattga cctcaacgga atgatggctg aaatccttgg taaatacact
     4741 ggaacctgta aagggaaagg tggatctatg catatcgctg accttgatgc tgggaacctt
     4801 ggtgccaatg gtatcgtagg tggtggtatg gggatcgctg tcggtgcagc cctcagtcag
     4861 caaatgcaaa ataccggtaa aatcgttgtt tgcttctttg gagatggtgc gaccaatgaa
     4921 ggtgttttcc acgaagcagt gaacatggct tctatctgga acctgccagt cattttctat
     4981 tgcattaaca acggttacgg tatctctgcg gatatcaaga aaatgaccaa tatagaacat
     5041 atccatcaac gtagcgccgc ttatggaatt cctggaatgt tcatcgaaga cggtaacaat
     5101 gtcatcgatg tctatgaagg atttcagaaa gctgtagacc atgttcgcag tggcaatggt
     5161 ccagtcttga ttgaaagtgt aacttatcgc tggcttggtc actcatcatc tgaccctggt
     5221 aaatatcgta cgcgtgaaga agtggaattg tggaaacaaa aagatccaat cgaaaacctc
     5281 cgcaattacc ttattgaaaa taacattgca agtgccgaag aattggaaaa aatccaagcg
     5341 caagtaaagg aagcagtaga agcttctgtt aaatttgcag aggaaagccc attcccaccg
     5401 cttgaatcag cctttgaaga tatttacaca gactaaggag aaagagataa aatggaaaca
     5461 aaaacaatgt ccttccgtga caccattatc cttgctatgt ctgaggaaat gcgtcgcgat
     5521 gaaaatgtgt tcttgatggg agaagatgtc ggtgtcttcg gaggagactt cggtacttct
     5581 gttggaatgc ttgaagaatt tggtccagaa cgtgtccgtg actgtccgat ttctgaagct
     5641 gccatctctg gagcagcagc aggagcagcc atgacaggac ttcgtccaat cgtcgatatg
     5701 accttcatgg acttctctgt tattgccatg gacaatatcg tcaaccaagc tgctaaaaca
     5761 cgttacatgt ttggtggtaa aggtcaggtt ccaatgactg ttcgttgtgc agctggtaac
     5821 ggagttggct ctgccgccca gcactcacaa tctctagagt cttggtttac tcacattcca
     5881 ggacttaagg ttgtggcacc tggaacacct gcggacatga aaggcctgct taagtcttct
     5941 atccgtgata acaacccagt tattatactt gagtacaagt cagaatttaa ccaaaaaggg
     6001 gaagtgccag ttgatccaga ctacacaatt ccacttgggg ttggtgaaat caaacgccaa
     6061 ggaacggatg taacagttgt tacttatgga aaaatgcttc gccgtgtggt tcaagctgct
     6121 gaagaattag cagaagaagg aatttcagtt gaaattgttg acccacgtac ccttgttccg
     6181 cttgataagg atatcatcat aaactcagtg aagaagactg gtaaggttgt tctggtcaac
     6241 gatgcccaca aaacaagtgg ctatatcggt gaaatttcag ctattatttc agaatcagaa
     6301 gcatttgact atctagatgc accaattcgc cgttgtgcag gagaagatgt gccgatgcct
     6361 tatgcacaaa acctagaaaa tgcaatgatt ccaacagttg aaagtatcaa agatgcaatc
     6421 cgaaaaactt ataacaaaga atagagttgc ataagataag ttatgtaaat aaaataaagc
     6481 tgacgagaaa ctttgtatct tttaggtgca gagctcttcg tcattaatat cttagattag
     6541 agcacgggct aaaagctcgg aaaaaagata aatctccttg gcttcatcga agccatcgtc
     6601 gatttcctat ttttcagtcg cttttgacgc cctttgtatc ataaatagaa ttggagaggt
     6661 catggctgat gacaagctaa gagcgactcc tgcagctaga aagttagcgg atgatttagg
     6721 gataaacctc tacgacgttt ctggctcagg tgcaaacggt cgtgtccaca aagaagacgt
     6781 ggaaacttat aaagacacaa acgtggttcg catttcgcca cttgcaaaac gaattgccct
     6841 cgaacataac attgcttggc aggaaatcca aggaaccggt catcgtggta aaatcatgaa
     6901 gaaggatgtt ttggccctgc ttcctgaaaa tatcgaaaac gatagcatca aatctcctgc
     6961 tcagattgaa aaagtggaag aagtccctga taacgtaaca ccatatggtg aaatcgagcg
     7021 tattccaatg acaccaatgc gtaaggttat tgcccaacgc atggttgaat cttacttgac
     7081 tgcgccaacc ttcaccctca actatgaagt tgatatgact gaaatgttgg ctcttcgtaa
     7141 gaaggttctt gagccaatca tggaagcaac tgggaagaag actactgtaa cagaccttct
     7201 ttcgcttgca gttgttaaga ctcttatgaa acacccatac atcaatgctt cattgacaga
     7261 agatggcaag actattatca ctcacaacta tgtcaatctt gccatggcag ttgggatgga
     7321 taatggattg atgacacctg ttgtttacaa tgctgagaag atgagtcttt cagaactggt
     7381 tgtagccttt aaggatgtta ttggccgtac cttggatggt aaattggctc caagtgagtt
     7441 acaaaattca acattcacaa tcagtaattt gggaatgttt ggtgttcagt cctttggccc
     7501 gattattaac caacccaact cagctatcct tggtgtcagt tcgacaatcg agaagccagt
     7561 tgttgtcaat ggtgaaattg tgattcgccc aatcatgagt ttaggattaa ccattgacca
     7621 ccgtgtcgta gatggtatgg ctggtgctaa gtttatgaag gacttgaaag agttgattga
     7681 aaccccaatc tcaatgttga tttaagagca agagtattca tttttaagat atagataaag
     7741 gaaggaagac atggccttag aagtaattat gccaaaagcc ggcgtggata tgacagaagg
     7801 acaaatcgtc caatggaata aaaaagtcgg agaatttgta aaagaaggag aaatcctttt
     7861 ggaaatcatg actgataaag tcagcatgga attggaagcc gaagaagatg ggtacttgat
     7921 tgccattctc aaaggagatg gtgaaactgt ccctgtaacg gaagttatcg gttaccttgg
     7981 tgaagaaagg gaaaacatcc caacagctgg agcagcatcg ccagaagcta gccctgtacc
     8041 tgtagcaagt acctcaaacg atgatggtaa gagcgatgat gcttttgata tcgttgtgat
     8101 tggtggaggt cctgctggtt atgttgcagc cattaaagct gcccaactcg gcggtaaggt
     8161 tgcccttgtt gagaaatctg aacttggtgg aacctgctta aaccgtggat gtattccaac
     8221 caagacctac cttcataacg ctgaaattat tgaaaatatc ggtcatgctg caaatcgtgg
     8281 tatcgtgatt gaaaatccta acttcactgt tgatatggaa aaacttttag aaactaaatc
     8341 taaagttgtt aatactcttg ttggtggtgt tgcaggactt cttcgtagct acggagttac
     8401 tgttcataaa ggaattggta caatcactaa agacaagaac gtcttggtaa atggttctga
     8461 attgcttgaa accaagaaaa tcattcttgc tggtggttca aaagtcagca agatcaacgt
     8521 ccctggtatg gaatcatcac ttgtcatgac tagtgatgac attcttgaaa tgaacgaagt
     8581 gccagaaagc cttgttatca tcggtggtgg agttgtcggt atcgaactcg gtcaggcctt
     8641 catgacattt ggttcaaaag tgactgttat cgaaatgatg gaccgtatag ttccagctat
     8701 ggatgcggaa gtttctaaga accttcgctt gatccttgag cgtaaaggaa tgaccatctt
     8761 gactggtact aaactgcaag aaatcattga ggaaaatggt caacttcgta tcaaggttga
     8821 aggaaaagac gatatcatcg caagcaaagc tcttctttca attggtcgta tgccagacct
     8881 tgaaggtatt ggagaggttg agtttgaatt ggatcgtggt tgtatcaagg tcaacgaata
     8941 catggaaact tcagttccag gcatttatgc accaggtgac atcaacggta ctaagatgtt
     9001 ggctcacgca gctttccgca tgggtgaagt ttccgctgaa aatgccctta aaggaaatca
     9061 tgcagttgcc aaattgaatt tgactcctgc agccatctac actctccctg aagtagcagc
     9121 agtaggtttg acagaagaac aagcccgtga gaaatacgat gttgccatcg gtaagtttaa
     9181 ctttgctgct aacggtcgtg ctattgcatc tgacgcagct caaggtttcg taaaagttat
     9241 cgctgataag aaatatggag aaatccttgg tgtacacatt attggtcctg cagccgcaga
     9301 attaataaac gaagcatcaa gcatcatcga aatggaaatc actgttgagg aaatgctgaa
     9361 gaccatccac ggacacccaa cttactctga agtgatgtac gaagcgtttg cagatgttct
     9421 aggaatggcc atccattcac ctaagaaaaa ataaaacgaa gatagattag actggaaggt
     9481 tatttccagt ctctatcata taaagtaaag ggatatcatg aaatacatta tcaatcattc
     9541 aaatgacact gcttttaata ttgccttgga agaatacgcc tttaaacacc ttttggatga
     9601 ggatcaaatc ttcctacttt ggattaacaa gccatctatc attgttggtc gtcaccagaa
     9661 cactatcgaa gaaatcaacc gtgattatgt tcgcgaaaat ggtattgagg tagttcgccg
     9721 tattagtggt ggtggagctg tttaccacga tttaaataac ctcaactaca cgatcatctc
     9781 caaagaagat gaaaataagg catttgactt caagagcttc tcaactccgg ttatcaatac
     9841 cctggctcaa cttggggtta aagctgagtt cacaggtcgt aatgaccttg agattgatgg
     9901 taagaagttc tgtggcaatg cccaagccta tatcaacggc cgcatcatgc accacggttg
     9961 cttgctcttt gacgttgatt tgtcagtcct cgcaaatgcc cttaaggttt caaaagataa
    10021 atttgaatca aaaggtgtga aatccgtccg tgcccgtgta actaatatta tcaatgaatt
    10081 accaaaaaaa atcacagtcg aaaaattccg tgatttactc ttggaataca tgaaaaaaga
    10141 gtacccagag atgactgaat acgtcttttc agaagaagaa ttggccgaaa tcaatcacat
    10201 caaggatact aagtttggaa cttgggactg gaactatggt aaatcacctg aatttaacgt
    10261 ccgtcgtgga accaaattca ctagtggtaa ggttgaagtc tttgctaacg ttactgaatc
    10321 aaaaatccaa gacatcaaga tttatggtga cttctttggt attgaagacg ttgctgcagt
    10381 agaagatgtc cttcgtgggg tgaaatacga acgcgaagat gttcttaagg cgctaaaaac
    10441 cattgatatc acacgctact tcgctggtat tagccgtgaa gaaatcgctg aagcggtagt
    10501 tggataaatc aaaaagaagt tggccaacta accaacttct ttttttgata tttatttaca
    10561 taatttaaaa tacgtaaaat cataaactat ccagagcatt cttttgttca tcactaacaa
    10621 tatgggtata gaggtcagtg acttgtgtgc tagcatgtcc tagttggtga ctgactaaaa
    10681 cttgtgattt agtcgcatca tagagcctag ttgctagtgt atggcgcagt ttatggggtg
    10741 ttacacgcac tttaaaatcc tctgagtatt tagcaaccat tttctcaacg ctagaagcat
    10801 cgatacgatt aggaacacct ctgtagagag ttaaaaaaag ggctgtatct gttttttccg
    10861 ttttatagcg ttgattccga atggccagat aattctctaa ataaggttta gcaaaagcag
    10921 cgacattgac tgagtcacgt ttgccacctt ttcgagtaac atcaataacc atcattttta
    10981 gattgagatc tcttagatct agattaacag cttcagataa gcgaacacca gatgccaaga
    11041 gaagggcaat aatggctaaa tctcgttctt tatttttgtt gaatgatgag agagctcgat
    11101 ttgaaagctg ttgtgggtgc tcttgatcga tataagttag aaaaccttct gtttcatcac
    11161 ctagaaagag tttttgcttg atattttcag ctctggcagc aagggtttct ttctttttct
    11221 tggttgaaac ttttttcatt acattacgat agaaataagg ttccccctga tcgttttcaa
    11281 cctcctcggt tagatacttg taaagactag aaagtgctga taaggttcga ttgatagttg
    11341 tctgtgaaac accttgtttt gttgtattag cattcagcaa gggacgttca cgtagataaa
    11401 ggataaagga ttccatgtct ttcttagaca tattttccaa aactgataaa ggaatatcgg
    11461 atattttatc agcgtttgaa ataccagact ccaaaaccca gctgaaaaat cggtcatatt
    11521 ccttaaggta ttcgtacagg gttgtaaaac tgtagggcac agccagctta gattggtagt
    11581 attccagaac ataccagggc atgagttgtt ttagtttgtc gattcgttcc agtaaaatct
    11641 cacgtttcat gtattttctc cataagtaag tatactagta gtatagcata gacttgtgta
    11701 tttttcaaga aaattatagt ttttcagaaa gatgttatag gagtttttca aagtgataaa
    11761 aagacttaga cctacaaaca aaacagaata aggaaaataa tgaaaatctc acccactaaa
    11821 cttctgttaa tactacataa ctgaagagct atataaggag ctatgagata caaaacacat
    11881 tgtataatag attgaaacta gaatagtaca tctggacttc taaaacattg ctagaaattg
    11941 atttaattgt cctgtttgtt ttatcctatt tctatttcat ttcactataa ttactattgt
    12001 tttctttttc atgattttaa tcttactgta cagatttgat acagtaaact cctttctagc
    12061 ttt
//
LOCUS       DAVHSO010000063        11998 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.064, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000063 DAVHSO010000000
VERSION     DAVHSO010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11998)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11998)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11998
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.064"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(89..538)
                     /locus_tag="VVR18_001826"
     CDS             complement(89..538)
                     /locus_tag="VVR18_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HEU6033301.1"
                     /translation="MTLTTFLLQAVASFLAIITFLIVLNVQRSMLLPGGILGMTVWLI
                     YLLLKEPTNVIVATFIAAIIGSCVSQILSILYKTPAVVFILAILAPLVPGYLSYRTTA
                     FFVTGDYNKALASATLVVMLALVISIGMASGTVILRLYHYIKTHRVS"
     gene            complement(540..1298)
                     /locus_tag="VVR18_001827"
     CDS             complement(540..1298)
                     /locus_tag="VVR18_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HEU6033302.1"
                     /translation="MEESKELNAVIDVIMLAGTILLKSGSEIHRVEDTMIRIAHSQGI
                     VDCNVLAMPAAIFFSIENTNISRMKRVTSSSYNIEKVCDVNQISRQLVGGQIDLETAF
                     KQLTALQAQPLPYTKLQVTLAATFSAPFFSVMFSGNIYDALGAGVATLFGFAFSLYVE
                     KFIRIPFVTAFAGAFVFGIIAQFWARYTGFPSTADLIIAGAVMPFVPGIALTNAVRDI
                     MTNHINSGMSKMFESLLITLALGAGTSVALVLMN"
     gene            complement(1413..3392)
                     /gene="pknB"
                     /locus_tag="VVR18_001828"
     CDS             complement(1413..3392)
                     /gene="pknB"
                     /locus_tag="VVR18_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HEU6033303.1"
                     /translation="MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVL
                     RTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYI
                     KEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
                     FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAV
                     TIALQHFQKPLPSVIAENPSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYN
                     RRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQ
                     APKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANF
                     EIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSD
                     VIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKAT
                     TIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVS
                     KPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAE
                     GMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP"
     gene            complement(3389..4129)
                     /locus_tag="VVR18_001829"
     CDS             complement(3389..4129)
                     /locus_tag="VVR18_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HEU6033304.1"
                     /translation="MEISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAG
                     NIASEMAVTDLGVAWVDTQIDTVNEVREWFAHYLEIENQKIHQLGQDEAYRGMGTTLE
                     VLAIIDNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAEAHPQKN
                     IITQSIGQKDEIQPDFGTVILESGDYLLLNSDGLTNMISGSEIRDIVTSDIPLADKTE
                     TLVRFANNAGGLDNITVALVSMNEEDAE"
     gene            complement(4144..5457)
                     /gene="rsmB"
                     /locus_tag="VVR18_001830"
     CDS             complement(4144..5457)
                     /gene="rsmB"
                     /locus_tag="VVR18_001830"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HEU6033305.1"
                     /translation="MTKVETARSLALAVLEDVFVNQAYSNIALNKHLKGSQLSAADKG
                     LVTELVYGTVARKLTLEWYLSHFIEDRDQLDSWLYVLLLMSAYQLRYLDKIPDHAVVN
                     EAVELAKLRKKGSEKLVNAVLRRILREGWPDIASIKRKNKRDSIAYSLPVWLVAKLKE
                     EYGEERAKAIFESLLVRNKASIRVTDLSRKEEIQALLEANNSLLATTGLVKEQGHFAG
                     HNLFANGAITIQDESSQLVAPTLDLQGDERVLDACAAPGGKTAHIASYLTTGQVTALD
                     LYDHKLDLIQENAQRLGVADRVQTQKLDARKVHEFFDQDSFDKILVDAPCSGIGLLRR
                     KPDIKYNKETADFASLQEIQLEILGSVCQILGKGGIITYSTCTIVSEENFQVVKVFLE
                     SHPEFEQVKLEHECKDIMKDGCILITPELYGSDGFFISQFRKISD"
     gene            complement(5450..6385)
                     /locus_tag="VVR18_001831"
     CDS             complement(5450..6385)
                     /locus_tag="VVR18_001831"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HEU6033306.1"
                     /translation="MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKV
                     IQETPVKQAAKEAGLSIYQPEKLSGSPEMEDLMKLGADGIVTAAFGQFLPSKLLDSMD
                     FAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDED
                     NVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKPEEEKLDWNKTN
                     RQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEDQGNPGEILSIGKKELIVATAEGA
                     LSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD"
     gene            complement(6398..8794)
                     /locus_tag="VVR18_001832"
     CDS             complement(6398..8794)
                     /locus_tag="VVR18_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HEU6033307.1"
                     /translation="MALAKIIVDVPLMQTDQPYSYRIPEEFEGMLEVGMRVHVPFGKG
                     NRLIQGIVLGLESQSDGEEMEQDLKDIAEVLDFSPVLTPEQLWLAEELRKSVFSYKIS
                     ILKAMLPGFLNSSYDKILYPLEGLSQEERVRLFGSEDSLAFSSLDLAKQAEMMRLTRK
                     GLLGLEYQAVDQKKVKTQSWYEVDHAQLEGVEISTRAKKKLELRDYLLSHPESASLAS
                     LLESYSREQVNFFVDQGAVTIVQKEVRRSAAYFEGIEASRPLELNPEQRQARDAVVSS
                     IGSSQPPFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFG
                     DKVAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEAAYK
                     QDSNPRYHAREVAILRAQYNQATLVLGSATPSLESRARAGKDVYQHLRLTQRANPLAT
                     IPEVQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSFVMCRECG
                     TVDTCPNCDISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKSHSIRYYGTGTQKAYDEL
                     AELFPQARILRMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDFPNVTLVGV
                     LNADTALNLPDFRSSERTFQLLTQVAGRAGRAEKAGQVLIQSYNPQHYAIRFAKDQDY
                     EGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPILG
                     PTPKPIARTHNLYHYQILIKYRLEDELGPTLNQVLALTQERENSELRLSIDHEPQQFL
                     "
     gene            complement(8860..9174)
                     /locus_tag="VVR18_001833"
     CDS             complement(8860..9174)
                     /locus_tag="VVR18_001833"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HEU6033308.1"
                     /translation="MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSE
                     KSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEEKKIKEQIAKEKEDGE
                     KI"
     gene            complement(9199..9825)
                     /gene="gmk"
                     /locus_tag="VVR18_001834"
     CDS             complement(9199..9825)
                     /gene="gmk"
                     /locus_tag="VVR18_001834"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HEU6033309.1"
                     /translation="MADRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQ
                     RPGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLE
                     IEVQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALM
                     REYDYAIVNDQVPLAAERVKCVIEAEHFCVDRVIGHYQEMLPKSPTTR"
     gene            complement(9955..11568)
                     /locus_tag="VVR18_001835"
     CDS             complement(9955..11568)
                     /locus_tag="VVR18_001835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HEU6033310.1"
                     /translation="MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSHEAAELMLLNAEQ
                     EATNLRGQAEREADLLVNEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELK
                     QIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE
                     LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRI
                     AGEYVAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFD
                     PIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHP
                     DLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAID
                     HEVEGSHVEIGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGA
                     RSESLESYIKRLHDLEEIANGFEGVQTSFALQAGREIRIMVNPGKIKDDKVTILAHKV
                     RKKIENNLDYPGNIKVTVIRELRAVDYAK"
BASE COUNT         3198 a         2852 c         2372 g         3576 t
ORIGIN      
        1 ttcataagtg cggtattctc gcacatatag aaagcgttgt taatttattt atctcatttt
       61 tcataaaatt cttttatttc tgtaaagtct acgatactcg atgtgttttt atataatgat
      121 acagtctgag aatcactgtt ccgctagcca ttccaataga gattaccaaa gccaacatga
      181 caaccaaggt cgcacttgcc agtgctttat tatagtcccc tgtcacaaaa aaggcagttg
      241 ttcggtagga gagataacct ggaaccagcg gtgccaaaat ggccaagata aagaccacag
      301 caggtgtctt ataaagaata cttaaaatct ggctgacaca agaaccaata atggctgcaa
      361 tgaaggtagc tacaatgaca ttggtcggtt ccttgagcaa gagatagatt agccagacag
      421 tcatgcccaa aatccctcca ggtaagagca tagaccgttg cacattgagt acaattaaaa
      481 aagtgataat ggcaagaaaa cttgctactg cttgtaataa aaaggttgtt agtgtcatat
      541 tagttcatca ataccaaggc gacagaagtt cctgccccta aagcgagggt aatgagcagg
      601 gattcaaaca tcttactcat accagagttt atgtggttgg tcataatatc acggaccgca
      661 ttggtcaagg caatacctgg tacaaacggc atgaccgcac cagctataat caaatctgcc
      721 gttgaaggaa aacctgtgta gcgagcccaa aactgggcaa ttatcccaaa gacaaaggct
      781 ccagcaaagg ctgtcacaaa gggaattcgg ataaattttt ccacatagag ggaaaaggca
      841 aaaccaaata aggtcgccac tcctgcccca agtgcgtcgt agatatttcc gctaaacata
      901 actgaaaaga aaggagcact aaaggtcgca gccagagtta cctgcaactt agtataggga
      961 aggggttgag cttgcaaggc cgtcaattgc ttaaaggctg tttctaagtc aatctgcccc
     1021 ccaactagct gacgagaaat ctggttcaca tcgcagactt tttcgatgtt ataagaagag
     1081 gaggtcacgc gcttcatgcg cgaaatattg gtattttcaa tagagaaaaa gatagcggca
     1141 ggcatggcaa ggacattgca atccacaatc ccctgcgaat gcgcgattcg aatcatggta
     1201 tcttctacac gatggatttc tgagccactt ttaaggagaa tagtccccgc tagcataatc
     1261 acatcaatga cggcatttaa ttcttttgat tcttccatgc tttcctcctt ttatcaactc
     1321 cctctattct atcacaaatc cggactcaaa aaaaatcttt gccatgaaat catgacaaag
     1381 attgattact cattttgatt atccatctgc ttttaaggag tagctgaagt tgttttaggt
     1441 ttgtagattg aaatcttgac tctagtctta ttgaggtcta ccttttcacc tgctctagga
     1501 ctttgttcaa caaccatgcc ttctgcacta cctgcaggcg ctgtcgtcac ttctacaact
     1561 tctatattag cttccttaat cccaacaatt tgaatcaaat tgttcttagt aaactccaag
     1621 ctggaaccaa tgtaactcgg catggcaaca cttgtaactt ttttagctac tgtcaagaca
     1681 atttgagtag gtttactcac atcataagtc gttccggcac ctggactttg tttcataatc
     1741 gttcctggtt cgctttcgct ggactcttct tcctctatct taatcaaatt ctcaggaacc
     1801 ttcttctgct tgagttctga gattacttct gtagagttcc gtccaatata gttccctaat
     1861 tgaatcgtcg tagctttttt agctactgtc aaaacaattt gagttgcctt gctcaagtca
     1921 taggtcgtac cttctggtag actttgcttc aggaccgttc cagcttcact ctcattcgac
     1981 tcttcttcct caattttaat caaattatct ggaacttttt tctcttttaa ttccgcgata
     2041 acatcagaag atttccggcc gacataatta ctaatttgga aggattgttt gcctgatgag
     2101 acaaccagat tgattttcgt tccttctttt cgaccagttc cagcgccagg atctgtacgg
     2161 ataatccgcc cttcttccac cttttcacta gcctctgtct tctcctcacc aatctcaaaa
     2221 ttggcttttt tgagcgttgc cttggcctct gcaactgtct gacctgccac atctggaatg
     2281 gcaatggttg caggagttct ggatagtatc caaataagag aagctgccac caatacaagg
     2341 ctggccaaca aaatcaggta acgcatctta aatctatgtt ttttcggtgc ttgtggttgg
     2401 taagtttcct ctgtcacagc ctggcttggg tttttgattg atttgtgttc tgtctgcgct
     2461 tgaaccttag gaatagatgt caaggtactc tgagaaacct ttggcaaggt cttggtatct
     2521 gccttgctcg tttcatcaaa gattaactta ctttcatttc tacgattgta ggacaagcta
     2581 ctagacaagt ccacatacat ctctgaaacc gagcggtagc gattggtcaa ctttttagca
     2641 gttgccttga taataacatt ttctaaagcc tgaggtacag atggattttc tgcaataacg
     2701 gacggcaggg gtttctggaa atgctggagg gcaatggtca ccgcgctatc cccgtcataa
     2761 gggatatggc ctgtcaacat ctcatagaaa ataatcccca tggcatagat atcactctgc
     2821 acagtcgcct tcgaaccacg cgcctgctct ggtgacaagt aatgaactga gcccaacatc
     2881 gagttagtct gggtcagact tgtctctgca aaggctacag caatcccaaa gtctgtgacc
     2941 ttggcagtcc catctggtgt caaaaggata ttttgaggtt tcaagtccct gtgaacaatt
     3001 cctcgagtat gggccaagcg catagccaag agaatttgtc ccatgatacg gactgcttct
     3061 tcattagaaa gaggataatg ttccttgata tagcgtttga ggtccagtcc agccacatac
     3121 tccatagcta ggtactgttg accgtcttcc tcgccaatat ctgttatccg aacgatatga
     3181 ggatggtcta gatctgccat agctctcgct tcacgctgaa aacgagctac agctatcggg
     3241 tccgtctggt agttggtcct cagaaccttc actgccactt cttccccatc taagattaag
     3301 tctttggcta ggtagacatc cgccatgcct cctcgaccaa tctgtttgac aatccgatag
     3361 cgtccggcaa aaatcttgcc gatttggatc attctgcatc ctcctcgttc atagaaacaa
     3421 gggcaaccgt aatgttgtct aaacctcctg cattgttagc aaaacgaaca agtgtctccg
     3481 ttttatctgc taaaggaata tcactggtta caatatcacg aatctcactg cctgaaatca
     3541 tgttggtcaa gccgtcacta ttgagcaaga gatagtcacc tgactcaagg ataactgtcc
     3601 caaaatcagg ctgaatttca tctttttgcc caatagactg ggtgataata tttttttgcg
     3661 gatgagcttc tgcctcttct ggtgtcaatt gaccagcctt gagcaattca ttaaccaaag
     3721 aatgatcgct cgtcaactga tggtattctt ctccacgaat caagccgata cgcgaatcac
     3781 caatatgagc atagatagcc tgattatcaa taatagcaag gacttccaaa gtagttccca
     3841 tgcctctgta agcttcatcc tgaccaagct ggtgaatctt ttgattttca atttctaggt
     3901 aatgggcgaa ccattcacgc acttcattga ctgtatcgat ctgggtatca acccaagcta
     3961 cacccaggtc tgtcaccgcc atttcactag cgatattccc tgcgcgatga cctcccatcc
     4021 catcagctaa aataatcatg gtacgtccag ctctattgac atagtggttg acatagtctt
     4081 ggttatttgt tcgtttctga ccaacatctg ttaataatga aatttccatg tgtcagttcc
     4141 ttcctaatcc gatatcttgc gaaattgact gatgaagaat ccatcacttc catacaattc
     4201 aggtgtaatg aggatacagc cgtctttcat gatatcctta cattcatgtt ctagttttac
     4261 ctgctcgaac tcgggatgac tctctaaaaa gaccttaacg acttgaaaat tctcctctga
     4321 gacgatagtg caggtgctat aagttattat accacctttg cctagtattt gacaaacact
     4381 acctaatatt tctaactgaa tttcctgcaa ggacgcgaaa tctgccgttt ctttattgta
     4441 tttgatatct ggttttcggc gcaaaagacc gattcctgaa caaggagcat ccaccaaaat
     4501 cttatcaaag gaatcctggt caaaaaactc atgcaccttt ctggcatcca atttttgagt
     4561 ttgaacccga tctgcaactc ccagacgttg ggcattttct tgaattaaat ccaacttgtg
     4621 gtcgtacaag tccagagcag taacctgacc tgtcgtaaga taagaggcta tatgggctgt
     4681 tttcccacct ggagccgcac aggcatcaag cactcgctca tcaccttgta aatcaagcgt
     4741 cggagcaacc agctgactgg actcgtcttg gatggtaatg gctccattcg caaacaaatt
     4801 atgccctgca aaatgccctt gctccttaac cagaccagtt gttgctaaaa gggaattatt
     4861 cgcctccaac aaggcttgga tttcctcttt tcgacttagg tctgttacac gaatactggc
     4921 tttgtttcgc actaacaggc tttcaaagat ggcttttgct ctctcctctc cgtattcttc
     4981 cttgagtttg gcaactagcc aaactgggag agaataggca atggagtcac gcttgttttt
     5041 tcgcttgatg ctagcaatat ctggccagcc ttcacgcaag atacggcgaa ggacagcgtt
     5101 gaccaatttt tcactgcctt ttttacggag tttggccaat tccactgctt cattgaccac
     5161 agcatgatct ggaatcttgt ccaaatagcg gagttggtag gcactcatga gaagaaggac
     5221 atagagccag ctgtctaact ggtctctgtc ttcgataaag tgggataggt accattccag
     5281 agtcaattta cgggctaccg ttccatagac cagctcggtc actaagccct tgtctgctgc
     5341 agagagctga ctccccttga ggtgtttatt taaggcaata tttgaatatg cttgattcac
     5401 aaaaacatcc tctagcactg ctagagctaa acttctagcc gtttctactt tagtcaccaa
     5461 atcgttctcc tacagtcaat gtacgtccaa ctccgttgag aaaggaagca atgtccatct
     5521 taggcttacc agctggctgc acttgtttga gggatagagc cccttcagcc gttgcgacaa
     5581 tcaattcttt cttgccgata gagagaatct cacctggatt tccctgatct tctactggta
     5641 gggcttcata aatcttaaag cggtcgccct taaggaaagt atgggcaaca ggccaggggt
     5701 tcattccacg aatttggtta aagagttgac gattggtttt gttccagtcc agtttttctt
     5761 cctctggctt tatatttgga gagaaggtaa cctgactcgt atcctgcggt tcaggtttga
     5821 tatcaccagc aatataggca ggcagagtgt ccaaaagcaa atcacgacca actagcgcca
     5881 atttttcaaa caaggtgcca acattgtcct catctgtgat cggaatgctg cgacgagaaa
     5941 tcatatctcc tgcatccatt tccttaacca tttccatgat ggtcacacca gcttcctcat
     6001 ccccttgaat caaggcataa tggataggcg caccaccacg gtgtctagga aggagggagg
     6061 catgaacgtt gacagcaaag tccatgctat caaggagttt gcttgggaga aactgcccaa
     6121 aagcagcagt cacaattcca tctgctccta gcttcataag atcttccatc tctggacttc
     6181 cagataattt ttcaggttgg tagatagata gtcctgcttc cttggcagcc tgcttgactg
     6241 gggtttcttg gataactttt ttacgaccaa cagcacggtc tggctgggtc acaacggcta
     6301 gaatttcgta acggtcatct gtcaaaagtc cttttaagac tgttgctgaa aagtcggggg
     6361 tccccataaa gattagtttt gtcatatctt ctccttttta taaaaattgc tgcggctcat
     6421 ggtcaatgct gagacggagc tcactatttt cccgttcttg agtcaaggcc aagacctggt
     6481 tgagggtcgg ccccagctca tcttctaaac ggtatttaat taaaatctgg taatgataga
     6541 ggttgtgggt acgggcaatc ggttttggcg ttggccccag aatgggactg gtctctgaca
     6601 agcctgaccg caaaatgttc atgacttcat aggcacgttt gaaaacctct tcttctttct
     6661 tgtgagaaag ggtaatacca atcgtgaaat agtaaggtgg atagccgagt tgtcgtctga
     6721 ttcccatttc ataggcataa aagccttcgt aatcttgatc cttggcaaat cgaatagcat
     6781 agtgctgcgg attgtaggac tgtatcaaga cttgacctgc tttttcagcc cgacctgctc
     6841 gacctgccac ctgagtcaag agctggaagg ttctctcaga agaacggaaa tcaggcagat
     6901 tcaaggccgt atccgcattt agaactccga ctagggtaac attgggaaaa tccaaaccct
     6961 ttgcaatcat ctgagtacca agtaaaatat ccgcttcccc tcgcccaaac tggtcaagca
     7021 aggcttggtg actgcctttc tttcgagtcg tatccacatc catcctcaga atgcgagctt
     7081 ggggaaagag ttctgctagc tcatcataag ccttctgagt tcccgtccca tagtaacgaa
     7141 tactgtggct cttacagtta ggacagacct gaggaatatc cttcgagaaa ccacaataat
     7201 ggcagttcat agtcttggta tccatatgca aggtcagaga aatatcgcag ttgggacaag
     7261 tatccaccgt cccacactcc cgacacatga caaagctaga ataaccacgg cgattgagca
     7321 tgagaaccac ctgctctttt ttaaccagac ggtcttggat agcctctagc aaaggaggcg
     7381 taaagtttga cgtctcattt tgtccgatat agtctcgaaa gtcaatcact tgaacctcag
     7441 ggattgtagc caaaggattg gcacgttggg ttagacgtaa gtgttgatag acgtctttgc
     7501 cagcacgcgc ccggctctct aagctcggcg ttgcagatcc aagtaccaga gttgcttgat
     7561 tatactgagc ccgtaaaata gctacctctc tggcatgata acggggattg ctgtcctgct
     7621 tataagccgc ttcatgctct tcatcaataa tcatgacacc cagatttttc agaggagcaa
     7681 agatagcaga tctggcacca acaacaactt gggcatcgcc acgctccacc ttgcgccatt
     7741 catcatactt ttcaccattg gataatcctg agtgaagaat ggctaccttg tccccaaaac
     7801 gtgctataaa acgctcggtc atctgaggag tcaaggaaat ctcaggtacc agcaaaatag
     7861 ctgtcttgcc cttatccagg gcaccttgga taatctgcaa gtaaacctcg gtcttcccac
     7921 ttcctgtaat cccttgaagt agaaagggag gttgagaact gccaatagaa ctcacaaccg
     7981 catcacgcgc ctgtctttgt tctggattta actccaaagg tctacttgct tcaattcctt
     8041 caaaataagc agccgagcgt cgaacttcct tttggactat ggtaacagca ccttgatcca
     8101 caaagaagtt gacttgctct cgcgagtagg actctaacaa gctagccaag gaagcgctct
     8161 ctggatgaga cagcagataa tctctcagtt ccaacttttt cttggcacgt gtagaaatct
     8221 caacaccttc taattgagca tggtcaacct cataccaaga ctgggtcttg accttctttt
     8281 gatcgactgc ctgatattcc agaccaagca ggccttttct agtcaaacgc atcatttcag
     8341 cttgcttggc aaggtctagt gaagaaaagg ctagcgaatc ttctgaacca aacaggcgca
     8401 ctcgttcttc ctgactcaag ccttccagag gatagagaat cttgtcatag ctagaattca
     8461 gaaatcctgg aagcatggcc ttgaggatag agattttgta ggagaagaca gatttgcgta
     8521 actcctcagc cagccagagt tgttctggcg tgagaacagg agaaaaatcc agcacctctg
     8581 caatatcttt taaatcttgc tccatctctt ctccatctga ttgggactcc aaaccaagaa
     8641 caatcccttg aatcaggcga ttacccttac caaaaggtac atgaacccgc atcccaactt
     8701 ccagcattcc ctcaaattcc tccggaatcc tgtaactata gggctggtcc gtctgcatca
     8761 agggcacatc tacgataatc ttagctaggg ccatcttctc acctcctcct tgtcagtaca
     8821 ttcttgcaat agaaaaaata agattgagtc cccccaacct taaatttttt caccatcttc
     8881 tttttcttta gcaatttgct ctttgatttt cttttcttct tcttctttgc ggcgtttttc
     8941 ttcttcgata cggcgacgca ctgcttcacg ttttccttct ggatctgggt gaattgtaac
     9001 gtttcctgat tcgatttctt ctaaagcgcg aagagttgat ttttcagact tgaaaccttg
     9061 agttgctggg gcacctgctt ccaattcgtg ggcacgtttt gcttccaaga ttacgagtga
     9121 atattttgaa ggaaccttgt cgagcaaggt atcaatagag ggttttaaca tcatttgctt
     9181 gtacctattt tctaaatttt atcgggtagt tggagatttt ggtaacatct cctgatagtg
     9241 accaatgaca cgatccacac agaagtgttc tgcttcaatc acacatttga cacgttcagc
     9301 agctaggggc acctgatcgt tgacaatcgc ataatcatac tcacgcatga gggcaatttc
     9361 ttccttggcc ttttcgattc gttgggcaat cacttctgca ctatctgttc cacgacctac
     9421 caagcgatct tgcaattcat ccaaatctgg tggtgtcagg aagataaaga cagcatctgg
     9481 aacctttttc ttgacctgaa gagcaccctg aacttcaatt tcaaggaaaa catcgattcc
     9541 cttgtccaag gtttcattga cataggtcag aggagttcca tagtagttgc cgacatattc
     9601 tgcgtattcc aacatctgtc cttgacgaat cagctcttca aattcttcac gagtacggaa
     9661 gaaatagtca acaccgtcca cttctccagg acgttgtgcg cgtgtcgtca tcgatacaga
     9721 gtattgaaat tggttttcag aactctcaaa aatctctctt ctaaccgttc cttttccaac
     9781 ccctgaagga ccagaaaaaa cgattagtaa gcctcggtct gccattgtgt ctccttttag
     9841 tcaatctgtg aaataacatt tctctagaat aatggcaaaa agccagatta tcctttacag
     9901 tctttctatc tagtgtaaca aaaaagcagt aatttttcaa ctgctctttc ttatttattt
     9961 agcataatct actgcacgaa gctcgcgaat cacggttacc ttgatatttc ctggataatc
    10021 gagattgttt tcaattttct tacgaacttt gtgagccaag attgtgactt tgtcgtcctt
    10081 gatttttcct ggattgacca tgatacgaat ttcacgtcct gcttgaaggg caaagctagt
    10141 ttgcactcct tcaaagccgt tagcaatttc ttccaaatca tggagacgct tgatgtagct
    10201 ttcaagagac tcactacgag cacctggacg ggctgcgctc aaggcatctg ctgcagcgac
    10261 gataactgct atcacgctct cagcttcaac atctccgtgg tgactagcaa tcgtattcac
    10321 cacaactggg ggttccttgt acttacgggc caattccata ccgatttcaa cgtggctacc
    10381 ttcaacctca tggtcaatgg ctttcccgat atcgtgaagg aatccagcac gacgggcaag
    10441 agccgcattt tcaccaagtt cgctcgccat gataccagcc aacttagcaa cctcaatcga
    10501 atggcgcaaa acattttgtc catatgaagt acggaactgc aaacgtccca taatcttcat
    10561 caagtctgga tgaaggtttg gcgcaccaat ttcataggca gcagcctcac cgtattcacg
    10621 aatcttattg tcaatctctt gacggttttt ctcaaccaac tcttcgatac gagctggatg
    10681 tatacgacca tctttgagca acatttccat agtcatacgg gcaatctcac gacgaatcgg
    10741 atcaaatcct gacaaggtca ccacttctgg tgtatcgtcg ataatcacat cgacccctgt
    10801 caaactttca aaggtacgaa tgttacgacc ttcacgacca ataatgcgtc ccttcatagt
    10861 atcgtctggc agatgaactg ttgagtttgt tgactccgct acatattcac cagcgatacg
    10921 ttgcatagct tgaaccaaga tgtccttggc cattttgtca gaacgttcct tgacctcttg
    10981 ctcagcttcg cgaatgcgac tggcaatctc cctggtcaag ttttcctctg tctgagccaa
    11041 gataatatct cgtgcttctg cctgagacag agcaccaata cgctctagtt ctgcttcttt
    11101 ttgtctttcg acttcctcta attgctcttc acgcgcatca aggtttttcg ctctatcaga
    11161 aatactttgt tctttttgtt caagtgtttg ttctttactc gtcaaattgt cgtccttacg
    11221 gtcaaggcta gtagctctct ctgtcaaacg actttcgatt tgtttgagtt cttgacgttc
    11281 tgatttaaat tcagcgtcca cttcttcacg gtattttctg gcttcttctt tggcctccaa
    11341 tagtgcttct tttttaagag acttgctttc acgtttggct tcattaacaa gtaaatccgc
    11401 ttcacgctca gcttgtccac gtaaattagt tgcttcttgt tcagcattta aaagcatcaa
    11461 ctctgcagct tcatgagatg atttcatctt agctgagatg ctgacatatc caatgactaa
    11521 accaatgatg acggcaaaaa cagcaatcgc aagcgacatg atctccatgt ttttacctca
    11581 ttttattgtt attccgaatg acacacattc ttttacattc taccataaaa aagtgatttt
    11641 cacaaaccta aaatagaata tgttttgggg aatttagtct gaattttagg attacacttc
    11701 cttggttttt taaggagata agtcagtgtc gctatcaaaa agttccaccg aatttctaca
    11761 actatggatt ttctattgtt gtgccaaata gtgttccact agattcaaac attttgcttt
    11821 caagtctttg aaaattcact ttaggaaatt acagcttatc ttcaagatca aatttgtcat
    11881 aaattaactt tttttattta gttgtatcaa tttatttctt aagtattaat ttatcctcat
    11941 cgaaagcttt taaaatatac tcattaatca atttattatc ttcttcattt tttgaaaa
//
LOCUS       DAVHSO010000064        11936 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.065, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000064 DAVHSO010000000
VERSION     DAVHSO010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11936)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11936)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11936
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.065"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(151..495)
                     /locus_tag="VVR18_001836"
     CDS             complement(151..495)
                     /locus_tag="VVR18_001836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033311.1"
                     /translation="MPLHTGKFDLNEYGKYLAEKSAEIYEEKTKQAVDAMERHRQECL
                     ARDAKWQAIVDRSDELLKEKKEREHQQEIERLMEEKRKEVDREVSQRLSMPNEHQKKL
                     NKAMSEMLKDLF"
     gene            complement(564..1142)
                     /locus_tag="VVR18_001837"
     CDS             complement(564..1142)
                     /locus_tag="VVR18_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033312.1"
                     /translation="METLQTIETKIDKLIEQNKKAIEMTEAELVKVNQAISDTQAKLV
                     QAQKEINSEKYVEAKGDLWTAERTKEFHEGRLKKLTKDPVITYDEYHAMVAEVYKLAD
                     EQQKTFYEPARKKVMEIVKLGDDSMKEAKYVDSILKKLEKDISKNNEEYKKGKNGYWL
                     SGFYSGLSYEPRDALYGYRYRLNEMAENFKRE"
     gene            complement(1296..1460)
                     /locus_tag="VVR18_001838"
     CDS             complement(1296..1460)
                     /locus_tag="VVR18_001838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2292 domain-containing protein"
                     /protein_id="HEU6033313.1"
                     /translation="MNPNKDYTPFLQDNFIIFNKDGIIEMRKIPDFGSVVFTSQDGNI
                     VQIETTIKER"
     gene            complement(1999..3450)
                     /locus_tag="VVR18_001839"
     CDS             complement(1999..3450)
                     /locus_tag="VVR18_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001083579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="virulence-associated protein E"
                     /protein_id="HEU6033314.1"
                     /translation="MNSNDIVNKIIEENQQEAPPEVVDLTQARKTNEEHNSLNLAKRP
                     RGDGFDRGLDNLRKILSGDSKLKGAIQYNTFTYEIEVTRPMKLNGRTLNGAIDDLIIR
                     EIRAYIATKYKLDYKKPDIADFLEIVAGENSYNPLKDYLESCESEYKELVNQREPFDI
                     LRHYLNIKDDEYNRIIMDLFFRGAVAKVFDPTVKFDFVLDLTGRQGVGKTQFFEGLFT
                     NKYFTTVETFTDKDDKARMVRNWCVFDDEMVASKKASFSELKKFITETKLEFRPPYAS
                     SDRRLPKSFIIVRATNDHDYLNDLTGERRFLVAEVHKDTAYKGRKWTEKDRRAFWGAM
                     VVAWRANQVLNLTDEQEKLVNEVRSHYKFVDEILEDLERYLDTPYPKRMYQFPMTDRM
                     RYYYIYDMMNEGYYRNNRGGTVELDTDTYGELVDRDKMTINLFFHEVYLTDKAPPKDK
                     AKVKKYMQNRDGWEHRRSTRFGKSIKPAYVKKM"
     gene            complement(3443..3958)
                     /locus_tag="VVR18_001840"
     CDS             complement(3443..3958)
                     /locus_tag="VVR18_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001263812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033315.1"
                     /translation="MRVIELILSADKLPLFGFLKSTPTQVWKNGEHYKFIYFEPIGEG
                     LTAFHYKGLYVAVKDENEEVEGWELTRDLEIGLASPDLLMILKNLEVNKLTEQRQGLG
                     VELKGWVFNLICNGIYTRYETSLFVRLLFVNGYSFSQLVDLFSAIVKRKDLASYFLEV
                     ATKFYKEVAFE"
     gene            complement(3955..4227)
                     /locus_tag="VVR18_001841"
     CDS             complement(3955..4227)
                     /locus_tag="VVR18_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000492129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033316.1"
                     /translation="MFSLSRESEKDLTHGILEVVERYLEAHEKVPPRLTKLINRIELK
                     EELKISDNTLNKWESQGLRRYQPPDDGSRMIYYLVTDIWKFLGVDE"
     gene            complement(4220..4561)
                     /locus_tag="VVR18_001842"
     CDS             complement(4220..4561)
                     /locus_tag="VVR18_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU6033317.1"
                     /translation="MSLSENDKRVLRLIKVGAENSITGLEISLTTKLTERTVQDIIKR
                     LIIKHNIPIVGVRNGFYRGYFIPRNKGELLDGAKAFYNQVQEESKRLAVLMNSDLESY
                     KETLKEVGGYV"
     gene            complement(4542..4835)
                     /locus_tag="VVR18_001843"
     CDS             complement(4542..4835)
                     /locus_tag="VVR18_001843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033318.1"
                     /translation="MSYTVKIYLDFEKIPDETYFTKEIFLAMCTDNATKLAVTMGLLA
                     KQALDLETRAVILKTLNTIIENQKAILQGVASGQITFLNKSKGEEELDESIRE"
     gene            complement(4832..5047)
                     /locus_tag="VVR18_001844"
     CDS             complement(4832..5047)
                     /locus_tag="VVR18_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033319.1"
                     /translation="MNELDLSNTQAVFVSVVLIGILLYLNHRDRKKSAQIERENQQTI
                     ETPSDDLNPDYGRYIQLAGVRVSGGME"
     gene            complement(5049..5249)
                     /locus_tag="VVR18_001845"
     CDS             complement(5049..5249)
                     /locus_tag="VVR18_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033320.1"
                     /translation="MTLDLDNMTRSEFDKLMTKIKDRNPNLFQFIIDFLDDKVSTEEV
                     YDFLKMERSYQVNHIKNYKARA"
     gene            complement(5470..5619)
                     /locus_tag="VVR18_001846"
     CDS             complement(5470..5619)
                     /locus_tag="VVR18_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033321.1"
                     /translation="MEAKTHFARFMRRGMELARQLHSKEIQRDEFDRAWKRLGDQIEN
                     ETKKN"
     gene            complement(5621..6048)
                     /locus_tag="VVR18_001847"
                     /pseudo
     CDS             complement(5621..6048)
                     /locus_tag="VVR18_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516652.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(6233..6433)
                     /locus_tag="VVR18_001848"
     CDS             complement(6233..6433)
                     /locus_tag="VVR18_001848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEU6033322.1"
                     /translation="MSKLRGYRVMLGLTQQQMADKLKISLQSYNNKELGKTPFNDKER
                     LAIKSMVAEIKPDITIDEIFYS"
     gene            6653..7249
                     /locus_tag="VVR18_001849"
     CDS             6653..7249
                     /locus_tag="VVR18_001849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001080844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033323.1"
                     /translation="MNRLKELRQEKKLSQKEIAETLGFSLRSFQRMENGESQIKPEKA
                     QLLADYFGVSVANLLGYENNFIESVKNLSQKDGSDEVFFKAFRAYYELKTADGRENLL
                     TLKDEDFLNKYREEILKNLIPNIKELSKQEIEKYLSDEKLLNEAKQKLNDFLFTIGTL
                     NPQETQLLVDFISLSYKDKQIVLNILGSLNQKETHHDL"
     gene            7239..8165
                     /locus_tag="VVR18_001850"
     CDS             7239..8165
                     /locus_tag="VVR18_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exoribonuclease"
                     /protein_id="HEU6033324.1"
                     /translation="MTYSFIALDVETANSFRGSLCSIGLVKFIDGQEVDSFYTLINPE
                     EKFSSRNIKIHAIKPEDVIGAPTFPEVQKEIINFIDNLPIVAHNARFDAYALQDVYLK
                     YEIPFDNIQYFCSYQVCKIILTDLPNHKLHTLAEHFKISLDHHNALSDARACGLILLE
                     ILKLSKQTSIRKMLKNLGYPELGLIGKHGFVKNKSTYIADSGVSNLKNDDKKDNKNNI
                     SNNNEIPQTKIFDAKTKAKNIKFHYVNKWIYIILAIVLGWIGGHHFYAGYNRKGFLYL
                     LFSFTFIPMLLALFQVISALLKTPDSNGKILV"
     gene            8185..8853
                     /locus_tag="VVR18_001851"
     CDS             8185..8853
                     /locus_tag="VVR18_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HEU6033325.1"
                     /translation="MDYAQDYLDDILVRMAYHSSGIEGNTISLPETVSIILENTLPRN
                     GKSIREFYEIENHKQVFSYLLDSLANHQALTVGLVQDFHTLLVDRLQHDRGRFKQVQN
                     AIIGAEFQTASPAETPYLMTQWADNTAYRLDHAQNEKEILEILADTHIQIERIHPFSD
                     GNGRTGRLILMYLAMKYLNAPIIISKDSRAHYMELLANQNVTGLADLFKKSLDYETAR
                     KGQF"
     gene            9970..10473
                     /locus_tag="VVR18_001852"
     CDS             9970..10473
                     /locus_tag="VVR18_001852"
                     /inference="COORDINATES: protein motif:HMM:NF022744.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3102 domain-containing protein"
                     /protein_id="HEU6033326.1"
                     /translation="MRGRKHYIKNTHHKQIAGQSIWEIGRRLKHVKERNLTHGQFGSW
                     VESIGIARAEASRFIKIAEEIPNLGTYTNLGTKALYLIATLPAEEKQAQIDRIEQGDN
                     PTVRELQDLKLKFSAAKRKIMELQKGQEPTKEIVKEVPVMPADYQEALQNRQQLEERA
                     KSAEERN"
     gene            10702..11868
                     /locus_tag="VVR18_001853"
     CDS             10702..11868
                     /locus_tag="VVR18_001853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEU6033327.1"
                     /translation="MKITEYTKKDGTTVYRSSVYLGIDTVTGKKVKTTISGRTKRELK
                     AKALQAQIDFEKGGSTVYKAVEIKTYAELVENWLETYCHTVKKATLTIIKSRLNNYLL
                     PAFGDYKLDKLTPPVIQKQVNQWAKEYNQLGKGYQEYPQLNSLNKRILKYAVSLQVIP
                     FNPARDIIVPRRKEKEGQKLKYLDDDNLKKFLTYLEQLPNTYKNFYDTVLYKTLLATG
                     LRIRECLALKWSDIDLQNGTLDVNKTLNCEKEVTSPKTKSSIRVIDLDNKTVLMLRLY
                     KNRQAQVGREIGLTYEKVFSNSFDEYRDARALRSRLEKHLKLSDCPRLTFHAFRHTHA
                     SILLNAGLPYKEIQTRLGHAKLSMTMDIYSHLSKDNKKNATSFYEKAIEKLKSS"
BASE COUNT         3584 a         2457 c         1984 g         3911 t
ORIGIN      
        1 ggtgggaagt tcgggagctc cgagggggag gggggtatcc cccctccttc tcccttgctt
       61 ctccaatctc tttcacaaaa aatatttttc cgattcactt tattaaaaaa ctttttaatt
      121 atttttttat gaagtctttt tatgttctct ttaaaataaa tctttcaaca tttcactcat
      181 cgctttgttc agttttttct ggtgttcatt tggcattgat aggcgctgac taacttctct
      241 atcaacctct ttgcgcttct cttccatcaa gcgttcaatc tcttgctggt gctctctttc
      301 cttcttttct tttaatagtt catcggaacg atctacgata gcttgccact tggcgtctct
      361 tgctaaacat tcttgtctat gtcgctccat cgcgtcaact gcttgtttag ttttctcttc
      421 gtaaatctca gcagactttt ctgctaaata cttcccgtat tcgtttaaat caaacttacc
      481 agtatgtagg ggcattctat atacctcatc tttctatttg ttagtagggg ggataactga
      541 aggggggagg gggtatttta attttattcc cttttgaaat tctcagccat ttcattcaat
      601 ctatatctat agccatacaa tgcatctctt ggttcatagg ataaaccaga atagaaccca
      661 ctaagccaat aaccgttttt ccctttctta tactcctcat tatttttaga gatatccttt
      721 tcaagttttt taagtatact atcaacatac tttgcttctt tcatagagtc atccccaagt
      781 tttacaatct ccatcacttt ctttctcgct ggttcataga aagttttttg ttgttcatca
      841 gccaatttat agacttctgc aaccatagcg tgatattcat cataagtgat tacagggtct
      901 ttagttaatt ttttcaaacg tccctcatga aattcttttg tacgttctgc cgtccataag
      961 tcaccttttg cttcaacgta tttttctgag ttgatttctt tttgagcctg taccagtttt
     1021 gcttgagtgt ctgaaatagc ttggtttact ttaaccagtt ccgcctcagt catctcaata
     1081 gctttcttat tctgttcaat cagtttgtca attttagttt caatagtttg taatgtttcc
     1141 atgttctttt attcctcatt tcttttgatt gtgcttatta gtttcaactc tctactgggt
     1201 ctttattcct cattacttcc tctttctcaa aacaaaaaga gacgcaacaa aaaagctact
     1261 tagctttaat gttacgcctc tagttgtcta gtcagctatc tttctttaat tgtcgtttca
     1321 atctggacaa tattgccatc ttgactagta aataccacac ttccaaagtc tggtattttc
     1381 ctcatctcta ttataccatc tttgttaaaa ataataaagt tatcctgtaa aaatggagtg
     1441 taatctttgt ttggattcat ctgtttttcc tctctttttt ggtgccatat atttaacata
     1501 tcttctattc tgttaaattt aagcgacctc ccttctcgcc ttgtctatca agggggaggg
     1561 ctatttttgt gatttcctat ttacattttc tcattatgta aaatacaaat atgatttcag
     1621 tcttaaaagt tactcattta agttactatt tccatttctt tttaggtctc ctcctcacaa
     1681 ttccaaaaag tgtagtcatt ttaggatatc tagtggctac gctctccgcc ttacggtcac
     1741 aaggcttttc gccgtgcgta gtcatgtagt caccttgctc ccaaaaaaat aaacaataaa
     1801 cgccttttat ctcttatctt catatactct ttaataaata gaaaataact acatttttat
     1861 ataaaagtca ataataccaa gggtttaggg gtgtagtcag taaaatagta aaaacaacac
     1921 ttttttctaa ccccttatgt atcaagggtt ttcttcctgt ttaaaatgta gtcacttttt
     1981 aaaaataaac tacactgact acattttttt aacgtaagct ggtttaatac ttttaccaaa
     2041 tcttgttgat cgcctatgtt cccagccgtc tcggttttgc atatactttt taaccttagc
     2101 cttatccttt ggcggtgctt tgtcagtcaa atacacctcg tgaaaaaata ggttaatggt
     2161 catcttgtcc ctatctacca gttcgccata ggtgtctgtg tcaagttcaa ctgttccacc
     2221 cctgttattt ctatagtatc cctcgttcat catatcatag atataatagt agcgcattct
     2281 gtcggtcatc gggaactgat acattctttt tgggtaagga gtatctaaat agcgctccaa
     2341 atcctcaaga atttcatcta caaacttgta atggcttcta acctcattta ctagcttttc
     2401 ctgctcgtcc gtcaggttca agacttggtt agccctccaa gctactacca tagcgcccca
     2461 aaaggctcta cggtctttct ctgtccactt cctgccctta taggcggtgt ccttgtgtac
     2521 ctcggcaacc agaaagcgcc tttcccctgt caagtcgttt aaataatcat ggtcattggt
     2581 tgctctgaca atgataaaac tcttaggcaa tcgcctgtca cttgaggcat aaggcggtct
     2641 aaactctagc ttggtttctg tgatgaattt cttcaattct gaaaaactag cctttttact
     2701 ggccaccatc tcatcatcaa agacacacca gtttctcacc attctagcct tgtcgtcttt
     2761 gtctgtgaat gtctcaacgg ttgtaaaata cttgttagta aaaagcccct caaaaaattg
     2821 tgtctttcct actccctgcc ttccagtcaa gtccagcaca aagtcaaact taacggtagg
     2881 gtcaaacacc ttggcaaccg ctccacggaa aaacaaatcc atgataatac ggttatattc
     2941 gtcatccttg atattaagat aatgccttaa aatatcaaag ggctcacgtt gattcactaa
     3001 ctctttatac tcgctttcgc aagattccag atagtctttt aaggggttgt agctattttc
     3061 tccagccact atctccaaaa aatcagctat atcaggcttt ttatagtcta gcttatactt
     3121 ggtagcaata taagccctaa tctctctgat aatcaggtca tcgattgcac cgttcagggt
     3181 tctaccgttt agcttcattg gtctagtcac ttcaatttca tatgtaaaag tgttgtactg
     3241 tatcgcccct tttagcttgc tatctccgct caaaatcttt ctcagattgt ctaaacctct
     3301 atcaaagccg tcccctcttg gtctctttgc caagttcagg ctattgtgtt cctcgttggt
     3361 tttccttgct tgggtcaagt ccaccacttc aggcggtgct tcttgctgat tctcttcaat
     3421 gattttattt acaatgtcat tgctattcaa aagccacctc cttatagaat tttgtcgcta
     3481 cttctagaaa gtagcttgct aggtctttgc gtttgacgat tgctgaaaac aagtccacca
     3541 gctgactaaa actgtagcca ttgacaaata gcaagcggac aaaaagcgaa gtctcatatc
     3601 tggtataaat gccgttacaa atcaggttaa aaacccagcc ttttaactcc actccaagcc
     3661 cctgccgttg ctctgtcaat ttatttacct ctaaattttt caggatcatc agcaagtcag
     3721 gactagccaa acctatttct aaatctctgg ttagttccca gccctctact tcctcgtttt
     3781 cgtctttaac tgccacatac aaacctttgt agtggaaagc cgtcaagccc tcgcctattg
     3841 gctcaaaata gataaatttg tagtgttccc cattcttcca aacttgggtt ggcgtagact
     3901 tgagaaagcc aaacaaaggc aatttgtcag cggataaaat taactctatc accctcattc
     3961 atccaccccc agaaacttcc agatgtcagt tactaaatag taaatcattc ttgaaccatc
     4021 gtccggcggt tgatagcgtc ttaaaccctg actttcccac ttattcagcg tgttgtcact
     4081 aattttcaat tcctctttga gttcaatcct atttattaac ttggtcaatc ttggcggtac
     4141 tttctcatgc gcttccaggt atctttccac tacctccaga atgccatgcg ttaggtcttt
     4201 ctcgctttct cggcttaggc taaacatatc cgcccacctc cttcaaggtt tctttgtagc
     4261 tttctaaatc gctattcatc aacaccgcta ggcgcttgct ctcctcctgt acttggttgt
     4321 aaaaagcctt agcaccatct agtaactcgc ctttgtttct aggtatgaaa taacctctat
     4381 aaaatccatt tctaaccccc acaattggga tgttatgctt gattattaaa cgcttaataa
     4441 tatcttgcac ggttctttct gttagcttgg ttgtcaggct gatttctaac cctgttatgg
     4501 agttctcagc ccctaccttg attagtctta aaactcgctt gtcattctct gatagactca
     4561 tccagttcct cctctccttt acttttattc aaaaaggtta tttgtccgct cgctacccct
     4621 tgcaaaatag ctttttgatt ttctatgatt gtattaaggg tttttaaaat aacagcccta
     4681 gtctctaaat ccaacgcttg ttttgccagc aaacccatag ttacagctaa ctttgttgca
     4741 ttgtccgtac acatagctag aaaaatctct ttagtaaaat aggtttcatc tggtattttt
     4801 tcaaaatcaa ggtatatctt cactgtgtaa ctcattccat ccctccggaa actcttaccc
     4861 ctgcaagctg gatatatcgc ccataatcag ggtttaaatc atcgctaggt gtttctatcg
     4921 tctgttggtt ttctcgctca atttgggcgc tttttttgcg gtctcggtgg tttagataaa
     4981 gcagtatgcc aatcagtacc acgctaacaa aaaccgcctg tgtgttgctt aaatctagtt
     5041 cgttcatgtt atgctctcgc tttgtaattc ttgatatgat ttacttgata gcttcgctcc
     5101 atcttcagaa aatcatacac ctcttcggtg cttactttat catctaaaaa gtcaatgatg
     5161 aactgaaaga ggttcggatt tctatccttg attttagtca ttagcttatc aaattctgat
     5221 cgtgtcatgt tatctaggtc tagagtcata tttttctcca ttagcctttc cttgtccttt
     5281 ttcttgcctg ttttctatat ggtatgcttc accactccaa acgctgggca tttgccccaa
     5341 gttggcggac gcttgtagtg atgtttcgtg ggtaatcacc cacatttttt ctaaacaagt
     5401 gcttagaatc gtcgtgtcag cactcgattt caaaaccttt tctaattgct tgcctgctct
     5461 tcggttttct tagtttttct tcgtttcgtt ttcgatttga tcgcctaatc ttttccaggc
     5521 tctatcaaat tcatcacgtt gaatttcttt actatgtaat tgccttgcta actccatgcc
     5581 tctacgcata aatctagcga agtgggtttt tgcttccatc ctagccctcc atcatgtcat
     5641 aaagtatagc gcgatgtttt ttaggaatgt gcttcatcgc gtccaatatg tcacgctctg
     5701 ctttttgtcg ggtttctgct tttactgttt tatcttctgc tatttcaaag gcgttttttg
     5761 ctactttgta gtagtctagc gactgtaaaa aatgaccacg ttcagacaat tctttttctt
     5821 ccagttcttc ttttacagta tcgtccaaga gttcgaactt agtgtaaacc ccttttctac
     5881 ttcaaaccct agacgcttgt tttgtctgag attgtaaagg ttgaccctgc aactctccaa
     5941 gttgcggtag cctaatactc cagcgatttc ttctaaattt ttaccttcta attcaggcaa
     6001 tttttcagct atatctttaa attttactac ttgatgtttc tttcccattg tttaccttgt
     6061 ctttctatgc tataatcaag gtatagaaaa aatatctata ctcttgatcc agtcacttgc
     6121 ttctgtcgcc aaacattcag caagtgactt ttttgttgtc aatccccagt ggtaaagcac
     6181 cacatgagaa atctgtaaat atagagtagt attgcgatta gttcgctcct ttctaactat
     6241 aaaatatttc gtctattgtt atgtctggtt tgatttctgc aaccattgac ttaatcgcta
     6301 gacgttcttt gtcattgaat ggcgttttac ctaattcttt gttgttgtac gactgcaaag
     6361 aaatttttag cttgtccgcc atttgttgct gagttagtcc taacataacc cgatagcctc
     6421 gtagtttgct catagatttg ctcctttcta aaaaaatccc cctccatgaa tagattgaaa
     6481 gtgtgaaagg ttggaggggg tgcttgacgt cattttatga cgcaacataa gcttgatttt
     6541 tattataacg tcagttttag acgttgtcaa tagttttttt gattttttta cgtcattttt
     6601 tgactttttt taaacataag gttataatca tctgtgaaag gtgtgataaa acatgaatag
     6661 attgaaagaa ttaagacaag aaaaaaagct atctcaaaaa gaaatagctg aaactttggg
     6721 attttcttta aggtcattcc aacgaatgga aaacggagaa agccaaatta aaccagaaaa
     6781 agcccaacta cttgctgatt acttcggggt aagcgttgct aacttactcg gttatgaaaa
     6841 caattttatt gaatctgtaa aaaatttaag tcaaaaagat ggctctgatg aagtattttt
     6901 taaagcattt agagcatact atgaactaaa aacagctgat ggtagagaga atttattgac
     6961 tttaaaagat gaagattttc taaataaata tcgtgaagaa attttgaaaa atctcattcc
     7021 aaacataaaa gaattaagta aacaagaaat tgaaaaatat ttatcagatg aaaaactttt
     7081 aaatgaagca aagcaaaaac ttaatgattt tctatttacc attggaacat taaatcctca
     7141 agaaacccaa ttactagtag atttcatatc cctatcttac aaagataagc aaatagtatt
     7201 aaatatactt ggctcactaa atcaaaagga aactcaccat gacttatagt tttatagctt
     7261 tagatgttga aacagcaaac tcatttcgcg gaagtctatg ttcaattgga ctagtaaaat
     7321 ttatagatgg acaggaagtt gactcctttt atactttaat taatcctgaa gaaaaattta
     7381 gtagtagaaa tataaaaata catgctataa aacctgaaga tgtcattgga gcccctactt
     7441 tccctgaagt acaaaaagaa atcattaact tcattgacaa tctacctatt gttgctcata
     7501 atgcaagatt tgatgcttat gctttacaag atgtttattt aaagtatgag attccttttg
     7561 acaacattca atatttttgt agctatcaag tatgtaaaat aatcctaact gatttaccaa
     7621 atcataaatt acatacctta gctgaacact tcaaaatatc tctagatcat cacaatgctt
     7681 tatcagatgc aagggcttgt ggtttaatat tattagagat attgaaatta tctaaacaaa
     7741 caagtataag aaaaatgctt aaaaatttag gatatcctga actgggatta attggaaagc
     7801 atggatttgt aaaaaataag agtacatata ttgccgactc tggagtttca aacttaaaaa
     7861 atgacgataa aaaagataat aaaaataata ttagcaataa taacgaaata ccacaaacaa
     7921 aaatttttga tgccaaaacc aaagctaaaa atattaaatt tcattatgtc aataagtgga
     7981 tttacattat attagctatc gttttaggtt ggataggtgg tcatcatttt tatgcaggat
     8041 ataatagaaa aggattttta tatctactat tcagtttcac ttttattcca atgcttcttg
     8101 cacttttcca agtaatttca gcattgttaa aaactcctga ttccaatggg aaaattttag
     8161 tttaatttta cagaaaggag aatcatggac tacgctcaag actacctgga cgatatactg
     8221 gtacgcatgg cctaccattc tagcggtatt gaagggaaca ctatttccct acccgaaacc
     8281 gtcagcatta tcttagaaaa caccttgcca cgcaacggca aaagtattcg tgagttttat
     8341 gagattgaaa accataaaca agtcttttct tatctcttgg actcattggc aaaccatcaa
     8401 gcccttactg tggggctggt tcaagatttt cacaccttat tagtggatag actacaacat
     8461 gatcgcggac gatttaagca agttcaaaat gctattatcg gggcggaatt tcaaactgct
     8521 agcccagcag aaacgcccta cctgatgacg cagtgggctg ataatactgc ttatcgctta
     8581 gatcatgctc agaatgaaaa agaaatctta gagattttag cagacaccca tatccagatt
     8641 gaacggattc acccatttag cgatggtaac ggtcgtactg gtcgcctgat acttatgtac
     8701 ttggctatga agtatctaaa cgctcctatc atcatctcaa aagactcaag ggcgcattat
     8761 atggaattgt tagcaaacca aaatgtaacg ggactagctg acctcttcaa aaagtcactg
     8821 gactacgaaa cagcacggaa gggacagttt taggacgaaa aaaagcgaac tttcccagcg
     8881 ttgagatttt tcgatactca aaaattttta aaaaacaaac caaaaagatt gacaaaaact
     8941 aaaaattaca gtattattag gcaacgagaa gagttcctgt tcccaagggg accgagtacg
     9001 cgaaacactg cctagttcta ctaggtggtg tttttgtata caaggaatat gaaaccattt
     9061 caaacattag gagatatcaa actacttaga aaaatccata atcgtaatgt tcaatattgc
     9121 caatacttcc cagcaaataa atgtcaatgc ctacacttat tttcaaaata aaaataaaaa
     9181 agtacaaaaa aagcgacaaa aaagttgatt tttaataaaa aaaacgatat agtgatgtta
     9241 gaaagtcgct tgtaattctg atatgtctgc gtatttttcg taagttgcct attgggtaac
     9301 ctgctatcag ttaagggctt ttatatttta caaaaaaatc agtgtatcgg cttattatgt
     9361 tggtacactt ttctttttac tacactagtt ttctacaaca aaaaaaagac aagctagctg
     9421 ctgctgactt gtctaatatc gcctgaactg aaataacggg aaagattcag gcgattagta
     9481 gcatcttgag agattggaag cagaaaggtc tggttactgt tgagttggga ctctttcaaa
     9541 cctcttagtc tacgctatta ttataccact cttgcattta aaaagcgact gacggcattt
     9601 ctcacgctca tcagtctata actctctaat gaagtataat gcggtataat ttagacgatt
     9661 ttcaacactt cggcatttta ggaacgctta aagcgctcta aacaatatca aaaaaataaa
     9721 actcttgaaa tattggggct catatgctag aatgaaagca taaagggaaa aacagtgctt
     9781 ctagcatatg taactaaaaa gccccaccgt tacagcgatg gggttttttg ctaccctctt
     9841 aaagggttaa atgctacttg ctacgtctct ttatccatag cttgaaaagc tcagacagta
     9901 cgttaacaag taacggagct agaaaaaggg aaaacaactc tagcatatat aacacctccc
     9961 ttctctaaat tgagggggcg aaaacattat atcaaaaaca cccatcacaa acaaattgca
    10021 gggcagtcaa tctgggaaat cggcagacga ctgaaacatg tcaaagaacg taatcttacc
    10081 cacggtcaat ttggaagttg ggtagagagt ataggaattg ctagagcaga agcaagtaga
    10141 tttataaaaa tagctgaaga gattccaaat ttgggcacgt acacaaattt ggggacaaag
    10201 gccctttatc tcattgcaac tcttccagca gaggagaaac aagctcaaat tgacaggatt
    10261 gagcaaggtg ataacccaac ggtcagagaa ttgcaagatt tgaaattaaa attttctgca
    10321 gctaaaagaa aaataatgga actgcaaaag gggcaagaac cgactaagga aatcgtgaaa
    10381 gaagttcctg ttatgccagc agactaccag gaagccctcc agaatcgtca acagctagag
    10441 gagcgtgcca agtcggcaga agaaaggaat tagagagtga atgaaatatc tttatcaaac
    10501 aatcttagtc agattgaact agaaaacacc caccacaaac aaccccatat aagccccata
    10561 tccgccttgt ttcatattct ggtacaattt accgtctgac tgcttaaaat cgaaaatagg
    10621 ggtattctcg tagcccctcg catggtataa actcaaaatc ttttctaatt gcttgcctgc
    10681 tgatggaaga ggagtaaaac catgaaaata acagaataca caaaaaaaga cggtactaca
    10741 gtctatcgct ctagcgtcta tcttggtatc gataccgtaa caggtaagaa agtcaagacg
    10801 actatatcag ggcgaaccaa gagagaactc aaagccaaag cactacaggc tcaaatagac
    10861 tttgaaaaag gaggctcaac agtatataag gcggtggaga taaaaactta tgccgaactg
    10921 gtggagaatt ggctggaaac atactgccat acagtcaaaa aggcaacact tacaataatc
    10981 aagagtagac taaataacta tctacttcca gcctttggag actacaaact agataagcta
    11041 acacccccag ttattcaaaa gcaagttaat caatgggcaa aagagtacaa tcaactaggc
    11101 aaaggttacc aagagtatcc gcaacttaac tcgctaaata aacgaatact taaatatgcc
    11161 gtatccttgc aagttatccc ctttaatcct gcccgtgata ttatcgtgcc acgtcgtaag
    11221 gaaaaagaag ggcaaaaact gaaatatctg gatgatgata acttaaaaaa attcttgact
    11281 tatctggagc agctgccaaa cacttacaaa aatttctacg atacggtgct atataagacg
    11341 cttttagcga ctggtttgcg tattcgtgag tgtttagccc tcaaatggtc tgatattgac
    11401 ttacaaaacg gtacactaga cgtaaataag actctaaact gtgaaaaaga ggtcactagc
    11461 cctaagacta aatcaagtat tagggtaatt gacttggata ataagacggt gctcatgctg
    11521 cggctttaca aaaatagaca agcgcaagtt ggtagagaaa taggcttgac ttatgaaaaa
    11581 gtattttcta attcctttga cgaatataga gacgctaggg cgcttaggtc aagacttgag
    11641 aaacatttaa aactttctga ctgccctcgt ttaacattcc acgctttccg tcatactcac
    11701 gctagtatct tgctcaatgc tggactacct tacaaagaga tacaaacacg gctcggtcat
    11761 gcaaaacttt ctatgaccat ggatatttat agccacttat ccaaagacaa caagaaaaat
    11821 gctacttcat tttatgaaaa agccattgaa aaattaaaaa gttcctaaaa agtccacaaa
    11881 ttttataaat cggttatgaa tcaagtcaca aataccgcta tactagggaa tttacc
//
LOCUS       DAVHSO010000065        11816 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.066, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000065 DAVHSO010000000
VERSION     DAVHSO010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11816)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11816)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11816
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.066"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(156..1787)
                     /locus_tag="VVR18_001854"
     CDS             complement(156..1787)
                     /locus_tag="VVR18_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HEU6033328.1"
                     /translation="MSINWQEILFHFLGGLGLFLYSIKTMGDGLQQAAGDRLRFYIDK
                     YTSNPFFGVLVGIGMTALIQSSSGVTVITVGLVSAGLLTLRQAIGIVMGANIGTTVTS
                     FLIGFKLGNYALPMLFIGAVCLFFTKNRTVNNIGRILFGVGGIFFALNLMSSAMAPLK
                     DLQVFKDYMIELSKNPVLGVFVGTGLTLLIQASSATIGILQNLYAGNLIDLQGALPVL
                     FGDNIGTTITAIIASLGANIAAKRVAGAHVAFNVIGTVVCVIFLVPFTVLIHWFEATL
                     NLAPEMTIAFAHGTFNITNTIVQFPFIGALAYFVTKIIPGEDEVVKYEPLYLDEHFIK
                     QAPSIALGNAKKELLHLGNYAAKAFDLSYKYIIDLDEKVAEKGHKTEEAINTIDEQLT
                     RYLIALSSEALSQKESEVLTNILDSSRDLERIGDHTEALLNLTAYLQRKNVEFSDAAL
                     KELEEVYRQTSDFIKDALDSVENNDIEKARSLVERHEAINKIERVLRKTHIKRLNKGE
                     CSTQAGVNFIDIISHYTRVSDHAMNLAEKVFAEQI"
     gene            2080..7020
                     /locus_tag="VVR18_001855"
     CDS             2080..7020
                     /locus_tag="VVR18_001855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000795197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacterial Ig-like domain-containing protein"
                     /protein_id="HEU6033329.1"
                     /translation="MKNPFFERRCRYSIRKLSVGACSLMIGAVLFAGPALAEETAVPE
                     NSGANTELVSGESEHSTNEADKQNEGEHARENKLEKAEGVATASETAEAASAAKPEEK
                     AGEVVAETPSAEAKPKSDKETEAKPEATNQGDESKPAAEANKTEKEVQPDVPKNTEKT
                     LKPKEIKFNSWEELLKWEPGAREDDAINRGSVVLASRRTGHLVNEKASKEAKVQALSN
                     TNSKAKDHASVGGEEFKAYAFDYWQYLDSMVFWEGLVPTPDVIDAGHRNGVPVYGTLF
                     FNWSNSIADQERFAEALKQDADGSFPIARKLVDMAKYYGYDGYFINQETTGDLVKPLG
                     EKMRQFMLYSKEYAAKVNHPIKYSWYDAMTYNYGRYHQDGLGEYNYQFMQPEGDKVPA
                     DNFFANFNWDKAKNDYTIATANWIGRNPYDVFAGLELQQGGSYKTKVKWNDILDENGK
                     LRLSLGLFAPDTITSLGKTGEDYHKNEDIFFTGYQGDPTGQKPGDKDWYGIANLVADR
                     TPAVGNTFTTSFNTGHGKKWFVDGKVSKDSEWNYRSVSGVLPTWRWWQTSTGEKLRAE
                     YDFTDAYNGGNSLKFSGDVAGKTDQDVRLYSTKLEVTEKTKLRVAHKGGKGSKVYMAF
                     STTPDYKFDDADAWKELTLSDNWTNEEFDLSSLAGKTIYAVKLFFEHEGAVKDYQFNL
                     GQLTISDNHQEPQSPTSFSVVKQSLKNAQEAEAVVQFKGNKDADFYEVYEKDGDSWKL
                     LTGSSSTTIYLPKVSRSASAQGTTQELKVVAVGKNGVRSEAATTTFDWGMTVKDTSLP
                     KPLAENIVPGATVIDSTFPKTEGGEGIEGMLNGTITSLSDKWSSAQLSGSVDIRLTKP
                     RTVVRWVMDHAGAGGESVNDGLMNTKDFDLYYKDADGEWKLAKEVRGNKAHVTDITLD
                     KPITAQDWRLNVVTSDNGTPWKAIRIYNWKMYEKLDTESVNIPMAKAAARSLGNNKVQ
                     VGFADVPAGATITVYDNPNSQIPLATLKSEVGGDLASAPLDLTNQSGLLYYRTQLPGK
                     EISNVLAVSVPKDDRRIKSVSLETGPKKTSYAEGEDLDLRGGVLRVQYEGGTEDELIR
                     LTHAGVSVSGFDTHHKGEQNLTLQYLGQPVNANLSVTVTGQDEASPKTILGIEVSQEP
                     KKDYLVGDSLDLSEGRFAVAYSNDTMEEHSFTDEGVEISGYDAQKTGRQTLTLHYQGH
                     EVSFDVLVSPKAALNDEYLKQKLAEVEAAKNKVVYNFASSEVKEAFLKAIEAAEQVLK
                     DHEISTQDQVNDRLNKLTEAHKALNGQEKFKEEKTELDRLTGEVQELLAAKPNHPSGS
                     ALAPLLEKNKALVEKVDLSPEELATAKQSLKDLVALLKEDKPAVFSDSKTGVEVHFSN
                     KEKTVIKGLKVERVQASAEEKKYFAGEDAHVFEIEGLDEKGQDVDLSYASIVKIPIEK
                     DKKVKKVFFLPEGKEAVELAFEQTDSHVIFTAPHFTHYAFVYESAEKPQPAKPAPQNK
                     VLPKPTYQPASDQQKAPKLEVQEEKVAFHRQEHENAEMLVGEQRVIIQGRDGLLRHVF
                     EVDENGQRRLRSTEVIQEAIPEIVEIGTKVKTVPAIVATQEKPAQNTAVKSEEASKQL
                     PNTGTADANEALIAGLASLGLASLALTLRRKREDKD"
     gene            7110..8306
                     /locus_tag="VVR18_001856"
     CDS             7110..8306
                     /locus_tag="VVR18_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HEU6033330.1"
                     /translation="MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTI
                     KYIIEQGGRAILFSHLGRVKEEADKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEA
                     AINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
                     SNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEK
                     ADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAF
                     AGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQTG
                     TIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGL
                     AALTEK"
     gene            8442..8969
                     /locus_tag="VVR18_001857"
     CDS             8442..8969
                     /locus_tag="VVR18_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEU6033331.1"
                     /translation="MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQI
                     GALTAVFSLRESFDESVHFGTSRILGNSIGGLYALVFFLLNTFFHEAFWVTLVVVPIC
                     TMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETILYVFVRVLETFMGVFVAIIVN
                     YDIDRIRLFLEKKEK"
     gene            9046..9402
                     /gene="glnR"
                     /locus_tag="VVR18_001858"
     CDS             9046..9402
                     /gene="glnR"
                     /locus_tag="VVR18_001858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000659547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor GlnR"
                     /protein_id="HEU6033332.1"
                     /translation="MKEKEFRRNMAVFPIGSVMKLTDLSARQIRYYEDQELIKPDRNE
                     GNRRMYSLNDMDRLLEIKDYISEGYNIAAIKKKYAEREAKSKKAVSQTEVRRALHNEL
                     LQQGRFASVQSPFGRG"
     gene            9439..10785
                     /gene="glnA"
                     /locus_tag="VVR18_001859"
     CDS             9439..10785
                     /gene="glnA"
                     /locus_tag="VVR18_001859"
                     /EC_number="6.3.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="HEU6033333.1"
                     /translation="MPITAADIRREVNEKNVTFIRLMFSDILGTMKNVEIPATDEQLD
                     KVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEG
                     EPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDL
                     APTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLV
                     VKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAY
                     HFLGGLIKHAYNYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGT
                     RLELRSVDPMANPYIAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDL
                     PSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY"
     gene            complement(10875..10994)
                     /locus_tag="VVR18_001860"
     CDS             complement(10875..10994)
                     /locus_tag="VVR18_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HEU6033334.1"
                     /translation="MPDIVFEIEFFHSDSLIFFYTSDDKSNSQKSQEDFSKNK"
     gene            11482..11816
                     /locus_tag="VVR18_001861"
                     /pseudo
     CDS             11482..11816
                     /locus_tag="VVR18_001861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187281.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
BASE COUNT         3793 a         2155 c         2550 g         3318 t
ORIGIN      
        1 aaatcgattt ctaacaatgt tttagaaata gaggtgtact attctagttt caatatacta
       61 tatatctgca gaatactctt tcagtttcat tcagcctagt cttgcttagg aaaaagtaaa
      121 aagccatcca attatgatgg atagcttctt ggttcttaga tttgttctgc aaaaaccttt
      181 tcagcaaggt tcatagcgtg gtctgataca cgagtgtagt gtgagatgat gtcgataaag
      241 ttgaccccag cttgtgttga acattcgcct ttgttgaggc gtttgatgtg ggtttttctg
      301 agaacacgtt ctatcttatt gattgcttca tgacgttcta caagactgcg tgctttttca
      361 atatcattgt tttccacact atccagagca tctttgataa agtcactagt ttggcggtaa
      421 acttcctcta attctttcaa ggcggcatcg gaaaattcaa catttttccg ttgaagatag
      481 gcagtcagat tgagtagagc ctccgtgtgg tctccaatcc gttccaaatc acgggaggaa
      541 tcaaggatat tggtgagcac ttcactttct ttttggctga gagcttcgct tgaaagggca
      601 atgagataac gtgttaattg ctcatcgatg gtgttaattg cttcttcggt tttatgccct
      661 ttttcagcaa ctttttcatc caagtcaatg atgtacttat aggaaaggtc aaaggcttta
      721 gcagcgtagt ttcctaagtg caagagctct tttttagcat ttcctagagc gatagatggg
      781 gcttgtttga tgaaatgttc atcaagatat aagggttcgt atttgacaac ctcgtcctct
      841 ccaggaataa tcttggttac aaagtaagcc agagctccga taaatggaaa ttggacaatg
      901 gtgttggtaa tattaaaggt tccgtgagca aaggcgatgg tcatttccgg tgctagattt
      961 agcgtagctt caaaccaatg aatcaggaca gtaaaaggaa ctagaaaaat aacgcagaca
     1021 actgttccga taacgttgaa ggcaacatga gctcctgcta cccgtttagc tgcaatatta
     1081 gcccctaaag aggcaatgat ggctgtaatg gttgtcccga tattgtcacc aaatagaact
     1141 ggcaaagctc cctgtagatc aattagattg ccggcgtaga ggttttgtaa aatcccaatg
     1201 gtagccgaag aagcttgaat tagcaaggtc aagccagtac cgacaaagac acccaaaaca
     1261 ggattcttac ttagctcaat catatagtcc ttaaagacct gtaaatcctt gagtggagcc
     1321 attgcgctgc tcatgagatt gagggcaaaa aagataccac cgacaccaaa gaggatgcgt
     1381 ccgatattat tgactgtccg atttttcgta aaaaagagac agacggcacc gataaagagc
     1441 ataggtaggg catagttacc taatttaaaa ccgatgagaa aggatgtgac agttgtccca
     1501 atattagcac ccatgacaat cccgatagcc tgacgtaagg ttaagagacc ggcactgacc
     1561 aggccgactg tgataactgt tacaccagaa ctagactgaa ttagagcagt catcccaata
     1621 ccaaccagaa ctccaaagaa aggattacta gtatatttgt caatgtaaaa acgaaggcga
     1681 tctccagcag cttgttgtaa accgtctccc atggtcttga tgctatataa gaatagcccc
     1741 agaccaccta aaaagtgaaa taaaatttcc tgccaattaa tggacatttc tttttcctcc
     1801 gaaaaataat cgcggaatat ctcctattct attttaaagg ataaaagtaa atctaacaag
     1861 tgttaatgtc aagtttgtaa aagaaaatta taattgataa gtgtattatt tttaagagtt
     1921 tttaacctta ttttagattt gtgcaaacag ttattgtttt ttgtctaaaa atgttttagg
     1981 ataaaaatgt gattatcatg gttctagagt ttgataaaaa actacagaat ataaagcgct
     2041 ttcttgaaaa caacaaaatc aatcttttag gaggagaaaa tgaagaatcc attttttgaa
     2101 agacgttgtc gttacagtat tcgtaagtta tcagtaggag cctgctcgct gatgattggt
     2161 gctgttttat ttgctggtcc agccttggct gaagaaactg cagttcctga aaatagcgga
     2221 gctaatacag agcttgtttc aggagagagt gagcattcga ccaatgaagc tgataagcag
     2281 aatgaagggg aacatgctag agaaaacaag ctagaaaagg cagaaggagt agcgacagca
     2341 tctgaaactg cagaagcagc tagcgcagct aaaccagagg aaaaagcagg tgaggtggtt
     2401 gcagaaacac catctgcaga agcaaaacct aagtctgaca aggaaacaga agcaaagccc
     2461 gaagcaacta accaagggga tgagtctaaa ccagcagcag aagctaataa gactgaaaaa
     2521 gaagtccagc cagatgtccc taaaaataca gaaaaaacat taaaaccaaa ggaaatcaaa
     2581 tttaattctt gggaagaatt gttaaaatgg gaaccaggtg ctcgtgaaga tgatgctatt
     2641 aaccgcggat ctgttgtcct cgcttcacgt cggacaggtc atctagtcaa tgaaaaagct
     2701 agcaaggaag caaaagttca agccttatca aacaccaatt ctaaagcaaa agaccatgct
     2761 tctgttggtg gagaagagtt caaggcctat gcttttgact attggcaata tctagattca
     2821 atggtcttct gggaaggtct cgtaccaact cctgacgtta ttgatgcagg tcaccgtaac
     2881 ggggttcctg tatacggtac actcttcttc aactggtcta atagtattgc agatcaagaa
     2941 agatttgctg aagctttgaa gcaagacgca gatggtagct tcccaattgc ccgtaaattg
     3001 gtagacatgg ccaagtatta tggctatgat ggctatttca tcaaccaaga aacaactgga
     3061 gatttggtta aacctcttgg agaaaagatg cgccagttta tgctctatag caaggaatat
     3121 gctgctaagg taaaccatcc aatcaagtat tcttggtatg atgccatgac ctataactat
     3181 ggacgttacc atcaagatgg tttgggagaa tacaactacc aattcatgca accagaagga
     3241 gataaggttc cggcagataa cttctttgct aactttaact gggataaggc taaaaatgat
     3301 tacactattg caactgccaa ctggattggt cgtaatcctt atgatgtatt tgcaggtttg
     3361 gaattgcaac agggtggttc ctacaagaca aaggttaagt ggaatgacat tttagacgaa
     3421 aatgggaaat tgcgcctttc tcttggttta tttgccccag ataccattac aagtttagga
     3481 aaaactggtg aagattatca taaaaatgaa gatatcttct ttacaggtta tcaaggagac
     3541 cccactggcc aaaaaccagg tgacaaagat tggtatggta ttgctaacct agttgcggac
     3601 cgtacgccag cggtaggtaa tacttttact acttctttta atacaggtca tggtaaaaaa
     3661 tggttcgtag atggtaaggt ttctaaggat tctgagtgga attatcgttc agtatcaggt
     3721 gttcttccaa catggcgctg gtggcagact tcaacagggg aaaaacttcg tgcagaatat
     3781 gattttacag atgcctataa tggcggaaat tcccttaaat tctctggtga tgtagccggt
     3841 aagacagatc aggatgtgag actttattct actaagttag aagtaactga gaagaccaaa
     3901 cttcgtgttg cccacaaggg aggaaaaggt tctaaagttt atatggcatt ctctacaact
     3961 ccagactaca aattcgatga tgcagatgca tggaaagagc taaccctttc tgacaactgg
     4021 acaaatgaag aatttgatct cagctcacta gcaggtaaaa ccatctatgc agtcaaacta
     4081 tttttcgagc atgaaggtgc tgtaaaagat tatcagttca acctcggaca attaactatc
     4141 tcggacaatc accaagagcc acaatcgccg acaagctttt ctgtagtgaa acaatcgctt
     4201 aaaaatgccc aagaagcgga agcagttgtg caatttaaag gcaacaagga tgcagatttc
     4261 tatgaagttt atgaaaaaga tggagacagc tggaaattac taactggctc atcttctaca
     4321 actatttatc taccaaaagt tagccgctca gcaagtgctc agggtacaac tcaagaactg
     4381 aaggttgtag cagtcggtaa aaatggagtt cgttcagaag ctgcaaccac aacctttgat
     4441 tggggtatga ctgtaaaaga taccagccta ccaaaaccac tagctgaaaa tatcgttcca
     4501 ggtgcaacag ttattgatag tactttccct aagactgaag gtggagaagg tattgaaggt
     4561 atgttgaacg gtaccattac tagcttgtca gataaatggt cttcagctca gttgagtggt
     4621 agtgtggata ttcgtttgac caagccacgt accgttgtta gatgggtcat ggatcatgca
     4681 ggagctggtg gtgagtctgt taacgatggt ttgatgaaca ccaaagactt tgacctttat
     4741 tataaagatg cagatggtga gtggaagcta gctaaggaag tccgtggtaa caaagcacac
     4801 gtgacagata tcactcttga taaaccaatc actgctcaag actggcgctt gaatgttgtc
     4861 acttctgaca atggaactcc atggaaggct attcgtatct ataactggaa aatgtatgaa
     4921 aagcttgata ctgagagtgt caatattccg atggccaagg ctgcagcccg ttctctaggc
     4981 aataacaagg tacaagttgg ctttgcagat gtaccggctg gagcaactat taccgtttat
     5041 gataatccaa attctcaaat tccgctcgca accttgaaga gcgaagttgg aggagaccta
     5101 gcaagtgcac cattggattt gacaaatcaa tctggtcttc tttattatcg tacccagttg
     5161 ccaggcaagg aaattagtaa tgtcctagca gtttccgttc caaaagatga cagaagaatc
     5221 aagtcagtca gcctagaaac aggacctaag aaaacaagct acgccgaagg ggaggatttg
     5281 gaccttagag gtggtgttct tcgagttcag tatgaaggag gaactgagga cgaactcatt
     5341 cgcctaactc acgcaggtgt atcagtatca ggttttgata cgcatcataa gggagaacag
     5401 aatcttactc tccaatattt gggacaacca gtaaatgcta atttgtcagt gactgtcact
     5461 ggccaagacg aagcaagtcc gaaaactatt ttgggaattg aagtaagtca ggaaccgaaa
     5521 aaagattacc tagttggtga tagcttagac ttgtctgaag gacgctttgc agtggcttat
     5581 agcaatgaca ccatggaaga acattccttt actgatgagg gagttgaaat ttctggttac
     5641 gatgctcaaa agactggtcg tcaaaccttg acgcttcatt accaaggcca tgaagttagc
     5701 tttgatgttt tggtatctcc aaaagcagca ttgaacgatg agtacctcaa acaaaaatta
     5761 gcagaagttg aagctgctaa gaacaaggtg gtctataact ttgcttcatc agaagtaaaa
     5821 gaagccttct tgaaagcaat tgaagcggcc gaacaagtgt tgaaagacca tgaaattagc
     5881 acccaagatc aagtcaatga ccgacttaat aaattgacag aagctcataa agctctgaat
     5941 ggtcaagaga aatttaagga agaaaagaca gagcttgatc gtttaacagg tgaggttcaa
     6001 gaactcttgg ctgccaaacc aaaccatcct tcaggttctg ccctagctcc gcttcttgag
     6061 aaaaacaagg ccttggttga aaaagtagat ttgagtccag aagagcttgc aacagcgaaa
     6121 cagagtctaa aagatctggt tgctttattg aaagaagaca agccagcagt cttttctgat
     6181 agtaaaacag gtgttgaagt acacttctca aataaagaga agactgtcat caagggtttg
     6241 aaagtagagc gtgttcaagc aagtgctgaa gagaagaaat actttgctgg agaagatgct
     6301 catgtctttg aaatagaagg tttggatgaa aaaggtcaag atgttgatct ctcttacgct
     6361 tctattgtga aaatcccaat tgaaaaagat aagaaagtta agaaagtatt tttcttacct
     6421 gaaggcaaag aggcagtaga attggctttt gaacaaacgg atagtcatgt tatctttaca
     6481 gcaccacact ttactcatta tgcctttgtt tatgaatctg ctgaaaaacc acaacctgct
     6541 aaaccagcac cacaaaacaa agtccttcca aaacctactt atcaaccggc ttctgatcaa
     6601 caaaaggctc ctaaattgga agttcaagag gaaaaggttg cctttcatcg tcaagagcat
     6661 gaaaatgctg agatgctagt tggggaacaa cgagtcatca tacagggacg agatggactg
     6721 ttaagacatg tctttgaagt tgatgaaaac ggtcagcgtc gtcttcgttc aacagaagtc
     6781 atccaagaag cgattccaga aattgttgaa attggaacaa aagtaaaaac agtaccagca
     6841 atagtagcta cacaggaaaa accagctcaa aatacagcag ttaaatcaga agaagcaagc
     6901 aaacaattgc caaatacagg aacagctgat gctaatgaag ccctaatagc aggcttagcc
     6961 agccttggtc ttgctagttt agccttgacc ttgagacgga aaagagaaga taaagattaa
     7021 atatcgaaaa atcttgtgaa atctttcctt atatttccaa agtgtgatat aatagtttcg
     7081 aataaaataa ataaaggagt ttttgtaaca tggcaaaact tactgttaaa gacgttgact
     7141 tgaaaggtaa aaaagtcctc gttcgtgttg acttcaacgt accattgaaa gatggcgtaa
     7201 tcactaacga taaccgtatc acagcagctc ttccaactat taagtacatc atcgaacaag
     7261 gtggacgtgc aattcttttc tctcaccttg gacgtgtgaa agaagaagct gataaagctg
     7321 gcaaatcact tgctcctgta gcagctgact tggcagcaaa acttggtcaa gatgttgttt
     7381 tcccaggtgt cactcgtggt gctgaattgg aagcggcaat caacgctctt gaagatggac
     7441 aagttctctt ggttgaaaac actcgttacg aagatgttga cggcaagaaa gaatctaaaa
     7501 acgatcctga acttggtaaa tactgggcat cacttggaga tggtatcttc gtaaacgatg
     7561 cattcggtac agctcaccgt gcacacgcat ctaacgttgg tatctcagca aacgttgaaa
     7621 aagcagttgc tggtttcctt cttgaaaacg aaattgccta catccaagaa gcagttgaaa
     7681 ctccagagcg tccattcgtg gctatccttg gtggttcaaa agtttcagac aagattggtg
     7741 ttatcgaaaa cttgcttgaa aaagctgaca aagtccttat cggtggtggt atgacttaca
     7801 cattctacaa agcacaaggt atcgaaatcg gtaactcact tgtagaagaa gacaaattgg
     7861 atgttgcgaa agctcttctt gaaaaagcaa acggtaaatt gatcttgcca gttgactcaa
     7921 aagaagctaa cgcatttgct ggttacactg aagtgcgtga cactgaaggt gaagcagttt
     7981 ctgaaggctt ccttggtctt gatatcggtc caaaatctat cgctaaattt gacgaagctt
     8041 tgactggtgc caaaacagtt gtatggaacg gacctatggg tgtatttgaa aacccagatt
     8101 tccaaactgg tacaatcggt gtgatggacg ctatcgtgaa acaaccaggt gttaaatcaa
     8161 tcatcggtgg tggtgactca gctgctgcag cgatcaacct tggacgtgca gataagttct
     8221 catggattag tacgggtggt ggagcatcaa tggaacttct tgaaggtaag gttcttccag
     8281 gacttgcagc cttgacagaa aaataagatt ttataaacaa atcaaagaag agagggatga
     8341 aagttcctct tttcttttgc ttaaaataaa aacgcttcct ctcaactatt actcataaaa
     8401 atcaccgatt tatgataaaa tggaaataga aagttgagat tatgagttat tttaaaaaat
     8461 ataaattcga taaatcccag ttcaaacttg gtatgcgaac ctttaaaaca ggtattgctg
     8521 tttttctagt tctcttgatt tttggctttt ttggctggaa aggtcttcaa attggtgctt
     8581 tgacagccgt ttttagcctg agggagagtt ttgatgagag tgttcatttt gggacttcgc
     8641 gtattctagg aaatagtatc ggtggactct atgccttggt cttcttctta ttaaatactt
     8701 ttttccacga agccttttgg gtgaccttag tagttgttcc aatctgcacc atgttaacca
     8761 ttatgacaaa tgtagccatg aataacaaag caggggttat tggtggtgta gcagctatgt
     8821 taatcattac cctatcaatt ccaagtggtg agacaatttt gtacgtgttt gtacgtgtat
     8881 tagaaacgtt tatgggagtt tttgtcgcaa ttatcgtaaa ttacgatatt gatcgtattc
     8941 gtctcttttt agagaaaaaa gaaaaataat gttacatttt ataacattat caattgacgt
     9001 ttgtcttttt ttagactata atagacagaa agaaggaaat tgtaaatgaa ggaaaaagaa
     9061 tttcgccgaa atatggctgt ttttcctatc ggcagtgtta tgaagttgac cgatttatcg
     9121 gcgcgtcaga ttcgttatta tgaagatcaa gagttgatca agcccgatcg aaacgaagga
     9181 aatcgtcgca tgtattcctt gaatgacatg gatcgtctgc ttgaaatcaa agattatatc
     9241 tctgaaggtt ataatatcgc tgccattaag aaaaaatatg ctgaacgtga agcgaaatcc
     9301 aagaaagcgg ttagtcagac tgaagtacgt cgtgcacttc acaatgaact cctccaacag
     9361 gggcgttttg cttcagtaca gtcacctttt ggtcgcggtt aggcaaccgc aagtagtcat
     9421 agattaagga gaaaacttat gccaatcaca gctgcagata ttcgtcgtga agtcaatgaa
     9481 aaaaatgtta cctttattcg tcttatgttc tcagatattt tgggaaccat gaaaaacgtc
     9541 gaaattcctg ctacagatga acagttagat aaggtcttgt cgaacaaggt tatgtttgat
     9601 ggatcttcta ttgaaggttt tgtacgtatc aatgagtcgg atatgtactt gtacccggac
     9661 ttggatacat ggacagtctt cccttgggga gatgaaaatg gaagtgttgc aggtctgatc
     9721 tgtgatgttt atacaacaga aggtgaacca tttgcgggtg accctcgtgg taatttgaaa
     9781 cgagctcttc gtcacatgga agaagttgga ttcaaatcct tcaaccttgg tccagagcca
     9841 gaattcttcc tatttaagtt ggatgaaaat ggggacccaa cacttgaagt gaatgacaag
     9901 ggtggctact ttgatttggc acctactgac cttgcggaca acacacgtcg tgagattgtg
     9961 aatgtcttga ccaaaatggg atttgaagta gaagcgagtc accacgaggt tgcggttgga
    10021 cagcatgaga ttgactttaa gtacgatgaa gttctccgtg cttgtgataa gattcaaatc
    10081 tttaaacttg ttgttaaaac cattgctcgc aaacacggac tttacgcaac atttatggcg
    10141 aagccaaaat ttggtattgc tggctcaggt atgcactgta atatgtcctt gtttgatgca
    10201 gaaggaaata acgccttctt tgatccaaat gatccaaaag gaatgcagct gtcagaaaca
    10261 gcttaccatt tcctaggcgg tttgatcaag catgcttaca actatactgc catcatgaat
    10321 ccaacagtta actcatacaa acgtttggtt ccaggttatg aagcgcctgt ttacattgct
    10381 tgggctggtc gtaaccgttc gccacttgtg cgcgtacctg cttcacgtgg tatgggaact
    10441 cgtcttgagt tgcgttcagt ggatccaatg gcgaaccctt acattgctat ggctgttctt
    10501 ttagaagttg gtttgtatgg tattgaaaat aaaatcgaag caccagctcc tatcgaagaa
    10561 aatatctaca tcatgacagc agaagagcgc aaggaagctg gtattacaga ccttccatca
    10621 actcttcaca acgctttgaa agctttgaca gaagatgaag tggttaaagc tgctctcgga
    10681 gatcacatct acactagctt ccttgaagcc aaacgaatcg aatgggcaag ttatgcaacc
    10741 ttcgtttcac aatgggaaat tgataattat ttagaccttt actaatatag aagaaagatt
    10801 gcctgtgggt aaacagtcac acagcagtct aagccatcaa atacctataa cccttaaaat
    10861 agcgatttcg gtcgctattt atttttcgaa aaatcctctt gactcttttg cgaattagat
    10921 ttatcatcag acgtgtagaa gaaaatcaag gagtcactat ggaaaaattc aatttcaaaa
    10981 acaatatcgg gcaagaaaac aagttacttc aaatcgaaat ctacaagttt actaactttt
    11041 gcaagcttca aaattacaca tctgtaaata ttttttcgaa agatatattt gaagccatag
    11101 taaattgaga ctagaatagt acactacatc tgctaaaaat ttctagaaac taatttaact
    11161 ttcctaatcg atttgtttac atcttatttc aatctactat attatctcaa taaatgatga
    11221 tggcgactgt tttgtttgtg cttgtcgatt tttgaatcct gatcgagcgg aagaatattt
    11281 ctgccgaggt tgccaagggg aaaatcctga agatattgaa ttttatgatg aacaattaca
    11341 ggcagaaaag gtggaggttt tgaatattcg attggaagta aaaaattgaa ttatctacaa
    11401 tctcatcaac aataaaccta tttcaacccc attatctata ggcgtatttt tacgcctttt
    11461 tatatacttg aagcacataa gaaacattat gggaagtttg ctgatggaag cactcaagaa
    11521 attgatgttc cttatgatat tcctgatact tgggagtggg tgaggataaa atcaatttat
    11581 tggaattttg ggcaaaataa gccagagaaa tcctttaggt atatagatac gtctagtatt
    11641 gatagaaaaa agaacataat caactacaaa aatctacaat atctttcacc tgaacaagcg
    11701 ccttcccgtg ctagaaaatt agtttcgcag aatagtgtct tattttcaac agttagacca
    11761 tatctaaaaa atattgctgt agttagagaa cttaaagagt atttgatagc tagtac
//
LOCUS       DAVHSO010000066        11732 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.067, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000066 DAVHSO010000000
VERSION     DAVHSO010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11732)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11732)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11732
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.067"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..384
                     /locus_tag="VVR18_001862"
     CDS             <1..384
                     /locus_tag="VVR18_001862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEU6033335.1"
                     /translation="LNANGDMATGWLQNNGSWYYLNANGAMATGWAKVNSSWYYLNAN
                     GAMATGWAKVNSSWYYLNANGDMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYV
                     NGLGALAVNTTVDGYGVNANGEWVN"
     gene            complement(614..1594)
                     /gene="dusB"
                     /locus_tag="VVR18_001863"
     CDS             complement(614..1594)
                     /gene="dusB"
                     /locus_tag="VVR18_001863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HEU6033336.1"
                     /translation="MTNLNTPFMIGNIEIPNRTVLAPMAGVTNSAFRTIAKELGAGLV
                     VMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIV
                     DINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVE
                     NALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAK
                     QRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLIN
                     LKGENVAVREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKA"
     gene            complement(1581..2453)
                     /gene="hslO"
                     /locus_tag="VVR18_001864"
     CDS             complement(1581..2453)
                     /gene="hslO"
                     /locus_tag="VVR18_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HEU6033337.1"
                     /translation="MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGR
                     TLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATG
                     EVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNV
                     LLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIY
                     GDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYN
                     FDEKDLEELIRDKS"
     gene            2618..4045
                     /locus_tag="VVR18_001865"
     CDS             2618..4045
                     /locus_tag="VVR18_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033338.1"
                     /translation="MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLT
                     KYVTLLNDKALDSGLELAIHSEDENLRLSIGAATKGRDIRNLFLDSAVKYQILVYLLY
                     HQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIRYFYFCLF
                     RKVWSSQEWEGHMQKPERKQEIANLEEICGASLSAGQKLDLVLWAHISQQRLRVNACQ
                     FQVIEEKMRGYFDNIFYLRLLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLH
                     TMEYILGFGGQLVDLLTQLIQEMKKEELLGDYTEDHVTYELSQLCAQVYLYKGYILQD
                     RYKYQLENRHPYLLMEHDFKETAEEIFHALPAFQQGTDLDKKILWEWLQLIEYMAENG
                     GQHMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKE
                     QTPVYYLKNDLDMEDLVAIRQLLFT"
     gene            4204..5712
                     /gene="glpK"
                     /locus_tag="VVR18_001866"
     CDS             4204..5712
                     /gene="glpK"
                     /locus_tag="VVR18_001866"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HEU6033339.1"
                     /translation="MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAG
                     WVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAI
                     VWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGE
                     LLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEV
                     RSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNT
                     GEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYA
                     RDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDI
                     IDTMQVDTQTTIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGL
                     SVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD"
     gene            5754..7580
                     /gene="glpO"
                     /locus_tag="VVR18_001867"
     CDS             5754..7580
                     /gene="glpO"
                     /locus_tag="VVR18_001867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glycerol-3-phosphate oxidase"
                     /protein_id="HEU6033340.1"
                     /translation="MEFSKKTRELSIKKMQERTLDLLIIGGGITGAGVALQAAASGLE
                     TGLIEMQDFAEGTSSRSTKLVHGGLRYLKQFDVEVVSDTVSERAVVQQIAPHIPKSDP
                     MLLPVYDEDGATFSLFRLKVAMDLYDLLAGVSNTPTANKVLSKDQVLERQPNLKKEGL
                     VGGGVYLDFRNNDARLVIENIKRANQDGALIANHVKAEGFLFDESGKITGVVARDLLT
                     DQVFEIKARLVINTTGPWSDKVRNLSNKGTQFSQMRPTKGVHLVVDSSKIKVSQPVYF
                     DTGLGDGRMVFVLPRENKTYFGTTDTDYTGDLEHPKVTQEDVDYLLGIVNNRFPESNI
                     TIDDIESSWAGLRPLIAGNSASDYNGGNNGTISDESFDNLIATVESYLSKEKTREDVE
                     SAVSKLESSTSEKYLDPSAVSRGSSLDRDDNGLLTLAGGKITDYRKMAEGAMERVVDI
                     LKAEFDRSFKLINSKTYPVSGGELNPANVDSEIEAFAQLGVSRGLDSKEAHYLANLYG
                     SNAPKVFALAHSLEQAPGLSLADTLSLHYAMRNELALSPVDFLLRRTNHMLFMRDSLD
                     SIVEPVLDEMGRFYDWTEEEKATYRADVEAALANNDLAELKN"
     gene            7650..8354
                     /locus_tag="VVR18_001868"
     CDS             7650..8354
                     /locus_tag="VVR18_001868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEU6033341.1"
                     /translation="MMNELFGEFLGTLILILLGNGVVAGVVLPKTKSNSSGWIVITMG
                     WGIAVAVAVFVSGKLSPAHLNPAVTIGVALKGDLPWASVLPYILAQFAGAMLGQILVW
                     LQFKPHYEAEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQAG
                     IGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPIPNKGDGDWSYAWIPVV
                     GPVIGAALAVLVFSLF"
     gene            8651..8854
                     /locus_tag="VVR18_001869"
     CDS             8651..8854
                     /locus_tag="VVR18_001869"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033342.1"
                     /translation="MPKWSNPDYVNELDPKIVDMLVEFHKSQGTLETPEAQAEIAQKR
                     EEIEQRRAELEDKKQELLNRLNK"
     gene            complement(8941..9447)
                     /locus_tag="VVR18_001870"
     CDS             complement(8941..9447)
                     /locus_tag="VVR18_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001815268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033343.1"
                     /translation="MRFGDTQVNILSDEVLEVVNPDGSVDTIERRADGVYINGAFYMA
                     YQKNEIDLNISFRSYDPNVWNYVNTIHGNKQANTFANFMTGAGISYMIGRIGALLGGP
                     WGAIIGGAYFGIQAYQSYLDSQSPYPYYITSTYIHVVQRKWKFITEYYRNSNYTGYVK
                     TVTTYVNF"
     gene            10624..>11732
                     /gene="ltrA"
                     /locus_tag="VVR18_001871"
     CDS             10624..>11732
                     /gene="ltrA"
                     /locus_tag="VVR18_001871"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HEU6033344.1"
                     /translation="MSKLLDKILSRENMLEAYNQVKSNKGSAGIDGMTIEEMDNYLRQ
                     NWRLTKELIKQRKYKPQPVLKVEIPKPDGGIRQLGIPTVMDRMIQQAIVQVMSPICEP
                     HFSDTSYGFRPNRSCEKAIMKLLEYLNDGYEWIVDIDLEKFFDTVPQDRLMSLVHNII
                     EDGDTESLIRKYLHSGVIINGQRYKTLVGTPQGGNLSPLLSNIMLNELDKELEKRGLR
                     FVRYADDCVITVGSEAASKRVMYSVSRFIEKRLGLKVNMTKTKITRPRELKYLGFGFW
                     KSSDGWKSRPHQDSVRRFKFKLKKLTQRKWSIDLTRRIEQLNLSIRGWINYFSLGNMK
                     SIVASIDERLRTRLRVIIWKQWKKKSRRLWGLLKLG"
BASE COUNT         3464 a         2274 c         2690 g         3304 t
ORIGIN      
        1 ctcaacgcta atggtgatat ggcgacagga tggctccaaa acaacggttc atggtactac
       61 ctaaacgcta acggtgctat ggcaacaggt tgggctaaag tcaacagttc atggtattac
      121 ctcaacgcta acggtgctat ggcaacaggt tgggctaaag tcaacagttc atggtattac
      181 ctaaacgcta atggtgatat ggcgacaggt tgggtgaaag atggagatac ctggtactat
      241 cttgaagcat caggtgctat gaaagcaagc caatggttca aagtatcaga taaatggtac
      301 tatgtcaatg gcttaggtgc ccttgcagtc aacacaactg tagatggcta tggagtcaat
      361 gccaatggtg aatgggtaaa ctaaacctaa tataactagt taatactgac ttcctgtaag
      421 aactttttaa agtattccct acaaatacca tatcctttca gtagataata tacccttgta
      481 ggaagtttag attaaaaaat aactctgtaa tctctagccg gatttatagc gctagagact
      541 acggagtttt tttgatgagg aaagaatggc ggcattcaag agactcttta agagagttac
      601 gggttttaaa ctattaagcc ttctccaatt gcaagagggc ttcaatctct gctagggtgc
      661 tagcttgcga aatggctcca cggagtttgg cagcgccaga tgttccacgg agatagtgag
      721 gagcgaggcc gcggaattca cgaactgcga cgttttctcc tttgaggtta atcaatcgtt
      781 tcaagtgttc gtaggcgatc ttcatcttgt cttcaaaggt caaatcaggt aggatttctc
      841 ctgtttcaaa gtaatggttg atttggttga agaggtaagg atttcccatg gcagctcggc
      901 caatcatgac tgcgtcagca ccaacttctt cgatgcgttg cttggcttct tggacagtac
      961 ggatatcacc gttggcgatg aatggaatct tggttagagc ttgggcaacc ttgtaaaggg
     1021 tctcaaggtc tgcgtggcca gtatacattt gttcacgggt acggccatgc atggcgaggg
     1081 cagaaacacc tgcagcctca gcagcgaggg cattttctac tgccagagat gggtccgccc
     1141 agccggtacg cattttgaca gtaagtggga tatcaaggac agactggacc ttgttgatga
     1201 tagagtagat cttgtcagga tccttgagcc acatagctcc agcttcgttc ttcacgattt
     1261 tgttgacagg gcagcccatg ttgatatcga cgatatcggt cttggtgttt tcttggatga
     1321 attctgctgc gcgtgctagg ctgtcttcat cgctaccaaa aagttggata gagacagggt
     1381 tttcgccctc atcgatatga agcatgtgca gggttttttc gttgttgtat tggattccct
     1441 tgtcagagac catttccatt acaacgagtc cagctccgag ctcttttgcg atggtacgaa
     1501 aggctgagtt ggtcacgcca gccataggcg ctaaaacggt acgattggga atctcaatat
     1561 tgccaatcat aaaaggtgta ttaagatttg tcacgaatga gttcctccag gtccttttca
     1621 tcaaagttgt aagtagtttg gcagaattga caagtgattt ctgccccgtg gtcttcctct
     1681 ttcatttcct gtaagtctga gcttggaagg ctggcaagag cgttcataaa gcgttcatgg
     1741 ctacagtcac attggaaacg gatttcttct tcagaaagac gcttgtaggc ttcgtccccg
     1801 tagatagcct tgaggagggc ttcgatatgg tcgtcgcttt cgagaagagt agagatagct
     1861 ggcatttctt ggatgcgttt ttcaaagcga gcaatctctt ctttcttggc tcctggcaag
     1921 acttgaacta ggaaaccacc tgcaaccttg accttgtctt cctcgtccaa aaggacattg
     1981 aggccgaccg ctgaaggcgt ttgttggctt tcagtaaggt aaaaggcaag gtcttcaccg
     2041 atttctccag agatgagggg agttatagag ttgtaaggat ttccagtacc gtagtctgtg
     2101 ataacgagga attgaccatt tccaacaaaa ggtccgacta ggacttcacc agtcgcagtc
     2161 tttttgatgt caacaccagg attttgaaca tagcctttga cgttcccctt ggtatcagcg
     2221 acggtgataa tagcacctag agagctagat cccaacacct taactgtaag tttggtattt
     2281 cctttttcat tggctgcgag aatctggctg gcgataagag ttcgaccaag cgctacagtt
     2341 gagctagctt gggtttgatg tttttcttga gcagtgcgga cggtttcagt gctatcaagg
     2401 acaaaagcac gaaaggctcc gctttctgat atagttttaa taattttatc catagctact
     2461 attttagcat aaaaatgccc aaagggggag ccgtgtgttt actgattttc aggataatgg
     2521 accaggaaat cagcatgaaa ataaaaagag aaacagatta tttcagcatt tgtaagattt
     2581 atgctatgct taaggtagaa aatgaaaggg gtaacaaatg tatttaggag atttgatgga
     2641 gaaagccgag tgtggtcaat tttcaatcct ttcctttcta ttacaagagt ctcagacgac
     2701 cgtcaaggct gtaatggaag aaacaggatt ttcaaaagca accctaacca aatatgtcac
     2761 cctgctcaat gacaaggctt tggatagtgg cttagagctg gctattcact cagaagatga
     2821 aaatctgcgt ctgtctatcg gtgcagctac caaggggaga gatattcgga acttgttttt
     2881 ggatagtgct gttaaatacc agattttggt ttatcttctc taccaccaac agtttttagc
     2941 ccatcagctg gctcaagaat tggtgattag cgaggctacg cttggtcgtc acttggctgg
     3001 tttaaatcag attttgtcag aatttgattt atccatccaa aatggacgtt ggcgaggtcc
     3061 agagcatcag attcgctatt tctatttctg tcttttccga aaggtctggt cgagtcagga
     3121 atgggaaggt cacatgcaga aaccagagag aaaacaggag attgccaatt tagaggaaat
     3181 ctgcggtgca agtttgtctg ccgggcagaa attggacttg gttctctggg ctcacatcag
     3241 tcaacaacgt cttcgggtca atgcttgtca gtttcaagtc atagaagaga aaatgcgagg
     3301 gtattttgac aatatctttt atcttcgttt gctgagaaag gttccgtcct tttttgctgg
     3361 gcaacatatt ccactaggag ttgaggatgg tgagatgatg atattcttct cttttctcct
     3421 atctcatcgc attcttcctc ttcatactat ggagtatatt cttggttttg gagggcagtt
     3481 ggtagattta ctgacgcaat tgattcaaga aatgaagaag gaggaactat tgggggatta
     3541 tacagaagac catgtcacct atgaactcag tcagctttgt gctcaagtct atctctataa
     3601 gggctatatt ttacaggatc gttacaagta ccagttagag aatcgtcatc catatttact
     3661 gatggaacat gattttaaag agacagcaga ggagattttt catgctctac ctgcttttca
     3721 acaggggaca gatttagata agaagattct ctgggaatgg ctccagttaa tcgaatatat
     3781 ggctgaaaac ggtggtcagc atatgcggat tggtctggat ttgacatctg gttttcttgt
     3841 cttttcaagg atggcagcca ttttgaaacg gtatttggaa tacaatcgtt ttattaccat
     3901 tgaagcttat gaccctagtc ggcattatga tttgctggtt accaataacc cgattcataa
     3961 gaaggaacag acaccagtct attatttaaa aaatgacttg gatatggagg atttggtagc
     4021 gattcgccag ttattattca cttaaaaggc ttggttaatc caggtctttt ttgtgaaatt
     4081 cacacaatct cctcacattt ttttaaaaat taaaaaaagt tgataaacaa gaaagcgctt
     4141 tattttgtat actagtaagt gtaaagagga aacacctcaa gatctttatc aggaggacag
     4201 tacatgtcac aagaaaaata catcatggcc attgaccagg gaactacaag ttctcgtgcc
     4261 atcattttca acaaaaaagg ggaaaaggtt agctcgagtc aaaaagagtt tacccagatt
     4321 ttccctcaag caggttgggt tgagcacaat gccaatgaaa tttggaactc tgttcagtca
     4381 gttattgcgg gtgctttcat cgaaagtggt gtcaagccaa atcaaatcga ggcaatcggg
     4441 attaccaacc aacgtgaaac aacggttgtc tgggataaga aaacaggact tcctatctac
     4501 aatgctatcg tttggcagtc acgccagaca gcacctttgg ctgagcaact aaaaagccaa
     4561 ggttatgtgg aaaaattcca tgaaaagact ggtttgatta ttgatgctta cttctctgct
     4621 accaaggttc gttggatttt ggatcatgta gaaggtgctc aagagcgagc agaaaaaggg
     4681 gaattgctct ttggtactat cgatacttgg ttggtttgga aattgactga cggtgcggct
     4741 cacgtgactg actactcaaa tgcagctcgt accatgcttt ataacattaa agaactcaaa
     4801 tgggatgatg agattttgga aatccttaac attccgaagg ctatacttcc agaagttcgt
     4861 tctaactccg aaatctacgg caagacagct ccattccatt tctacggtgg agaggtgcca
     4921 atctcaggta tggctgggga ccaacaagca gccctctttg gacagttggc ttttgagcca
     4981 ggtatggtta agaatactta tggaacaggc tctttcatca tcatgaatac tggggaagag
     5041 atgcagttgt ctgaaaacaa cctcttgaca accattggtt acggaatcaa cggtaaggtt
     5101 tattatgcct tggaaggttc tatcttcatc gcaggaagtg ctattcagtg gcttcgtgac
     5161 ggtcttcgca tggttgaaaa ttcaccagaa tctgaaaaat acgctcgtga ttctcacaac
     5221 aacgatgaag tttatgtcgt tccagccttt acaggtctag gcgctccata ctggaaccaa
     5281 aatgctcgtg gttccgtctt tggtttgact cgtggaacaa gcaaagaaga ctttatcaag
     5341 gcgactttgc aatcgattgc ttatcaagtg cgtgacatca tcgacaccat gcaagtggat
     5401 actcagacca ccattcaagt actgaaggtg gatggtggtg cagccatgaa caacttcctc
     5461 atgcagttcc aggcggatat tttaggcatt gatattgcac gtgctaaaaa cttggaaaca
     5521 acagctctag gagcggcctt cctagcaggt ttgtcagtag ggtactggaa agacttggac
     5581 gagttgaaac tcttgaacga gacaggagaa ctctttgagc catctatgaa cgaatctcgc
     5641 aaggaacaac tctacaaggg ttggaagaag gctgtgaaag caactcaagt ctttgcggaa
     5701 gtagacgact aatactggca gaataaagcg atttatttag aaagtgtgta aatatggaat
     5761 tttcaaagaa aacacgtgaa ttgtcaatta aaaaaatgca ggaacgcacc ctggacctct
     5821 tgattatcgg tggaggaatc acaggagctg gtgtagcctt gcaggcggca gctagcggtc
     5881 ttgagactgg tttgattgaa atgcaagact ttgcagaagg aacatctagt cgttcaacaa
     5941 aattggttca cggaggtctt cgctacctca aacaatttga cgtagaagtg gtctcagata
     6001 cggtttctga acgtgcagtg gttcaacaaa tcgctccaca cattccaaaa tcagatccaa
     6061 tgctcttacc agtttacgat gaagatggag caacctttag cctcttccgt cttaaagtag
     6121 ccatggactt gtacgacctc ttggcaggtg ttagcaacac accaactgcg aacaaggttt
     6181 tgagcaagga tcaagtcttg gaacgccagc caaacttgaa gaaggaaggc ttggtaggag
     6241 gtggagtgta tcttgacttc cgtaacaacg atgcgcgtct cgtgattgaa aacatcaaac
     6301 gtgccaacca agacggtgcc ctcattgcca accacgtgaa ggcagaaggc ttcctttttg
     6361 acgaaagtgg caagattaca ggtgttgtag ctcgtgatct cttgacagac caagtatttg
     6421 aaatcaaggc ccgtctggtt attaatacaa caggtccttg gagtgataaa gtacgtaatt
     6481 tgtctaataa gggaacgcaa ttctcacaaa tgcgcccaac taagggagtt cacttggtag
     6541 tagattcaag caaaatcaag gtttcacagc cagtttactt tgacacaggt ttgggtgacg
     6601 gtcgtatggt ctttgttctc ccacgtgaaa acaagactta ctttggtaca actgatacag
     6661 actacacagg tgatttggag catccaaaag taactcaaga agatgtagat tatctacttg
     6721 gcattgtcaa caaccgcttt ccagaatcca acatcaccat tgatgatatc gaaagcagct
     6781 gggcaggtct tcgtccattg attgcaggga acagtgcctc tgactataat ggtggaaata
     6841 acggtaccat cagtgatgaa agctttgaca acttgattgc gactgttgaa tcttatctct
     6901 ccaaagaaaa aacacgtgaa gatgttgagt ctgctgtcag caagcttgaa agtagcacat
     6961 ctgagaaata tttggatcca tctgcagttt ctcgtgggtc tagcttggac cgtgatgaca
     7021 atggtctttt gactcttgct ggcggtaaaa tcacagacta ccgtaagatg gctgaaggag
     7081 ctatggagcg cgtggttgac atcctcaaag cagaatttga ccgtagcttt aaattgatca
     7141 attctaaaac ttaccctgtt tcaggtggag aattgaaccc agcaaatgtg gattcagaaa
     7201 tcgaagcctt tgcgcaactt ggagtatcac gtggtttgga tagcaaggaa gctcactatc
     7261 tggcaaatct ttacggttca aatgcaccga aagtctttgc acttgctcac agcttggaac
     7321 aagcgccagg actcagcttg gcagatactt tgtcccttca ctatgcaatg cgcaacgagt
     7381 tggctcttag cccagttgac ttccttcttc gtcgtaccaa ccatatgctc tttatgcgtg
     7441 atagcttgga tagcatcgtt gagccagttt tggatgaaat gggacgattc tatgactgga
     7501 cagaagaaga aaaagcaact taccgtgctg atgtcgaagc agctctcgct aacaacgatt
     7561 tagcagaatt aaaaaattaa gaaaaaataa aagaggtgga gggcagcatt ccttgtcgct
     7621 cgtcccttct ttttaatgga gacagaaaga tgatgaatga attatttgga gaatttctag
     7681 ggactttaat cctgattctt ctaggaaatg gtgttgttgc aggtgtggtt cttcctaaaa
     7741 ccaagagcaa tagctcaggt tggattgtga ttactatggg ttgggggatt gcagttgcgg
     7801 ttgcagtatt tgtatctggc aagctcagtc cagctcattt aaatccagct gtgacaattg
     7861 gtgtagcttt aaaaggtgac ttgccttggg cttccgtttt gccttatatc ttagcccagt
     7921 tcgcaggggc tatgctgggt cagattttgg tttggttgca attcaaacct cactatgagg
     7981 cagaagaaaa tgcaggcaat atcctggcaa ccttcagtac tggaccagcc atcaaggata
     8041 ctgtatcaaa cttgattagc gaaatccttg gaacctttgt tttggtgttg acaatctttg
     8101 ctttgggtct ttacgatttt caggcaggta tcggaacctt tgcagtgggt accttgattg
     8161 tcggtatcgg tctatcgcta ggtgggacaa caggttatgc cttgaaccca gctcgtgacc
     8221 ttggacctcg tatcatgcac agcatcttgc caattccaaa caagggagac ggagactggt
     8281 cttacgcttg gattcctgtt gtaggccctg ttatcggagc agccttggca gtgcttgtat
     8341 tctcactttt ctagtttata ctcttcgaaa atcaaattca aaccacgtca gcgtcgcctt
     8401 accgtactca agtacagctt gcggctatct tcctagtttg ctctttgatt ttcattgagt
     8461 attagaaaac aattatgttg atagagcttg ggcaagagcc caatttcagc aaaaaatgaa
     8521 gtaaatcttc tcataataaa acgcatcata tcaagcacga aaattccacg aggtcaacta
     8581 cagtcagaaa gctgaacaac aagccaaaac gcccaaaaaa ggcggcaaaa agcaagcacc
     8641 tgcaagcaac gtgccgaaat ggtcaaatcc tgattatgtc aacgaattag acccaaaaat
     8701 cgttgatatg ctagtagaat ttcacaagtc acaaggcact ttggaaactc ccgaggcgca
     8761 agcagaaatc gcccaaaaac gtgaagaaat cgagcaaagg agagctgagc ttgaggataa
     8821 aaaacaagag cttttgaacc gcttgaacaa atagagtttc gcaagtatta tgcttacaaa
     8881 ttacttgagc aattaactaa aatataaacc ctgcctttat atctaggcag ggtttatatt
     8941 ttagaaattc acgtaggttg ttacggtttt tacataccca gtatagtttg agtttctata
     9001 gtattcagtg ataaacttcc attttctttg aacaacatgg atataagtac ttgttatgta
     9061 gtatggatat gggctttgtg aatccaagta agactgataa gcttgtatac caaaatatgc
     9121 tccaccaatt attgcacccc atggaccccc caataaagca cctatcctac caatcatata
     9181 actgattcca gcaccagtca tgaagttagc gaatgtgtta gcttgtttat tcccatgtat
     9241 tgtgttgacg taattccaaa cattaggatc gtatgatcta aaagatatat ttaggtcgat
     9301 ttcattcttt tgataagcca tataaaatgc cccattgata tagacgccgt cagcacgtcg
     9361 ttcaatagtg tctacacttc catctggatt gacaacctca agaacttcat cgcttaaaat
     9421 atttacttgc gtatctccga accgcactga tgagccattc tcaaactgag cctcaccaga
     9481 tctttagagt ttgccgataa gctatcatca gcaaaaacaa caagcgacgg ggaaatgcta
     9541 gacatacaga aaacagacat aactagcaaa cacatgcatt taaacatctt agacataacg
     9601 gaaactcctt tgtatttttg atttttttca acttttatta tacaataaaa ccaaataaaa
     9661 agaaagcggt aacaatatgc ttaatgcgaa aattttttat atatttttat gtttgatcgt
     9721 tatcgaaact acaggcttgt tgttgttgaa aagaggtctc gaaatgggtt atttagacac
     9781 agaagctatt atcctcgcag ttttttcatt tgctttttac aacctatgtt cattcgcttg
     9841 ggtctgctct acaataaaaa ataaatagac gtattttcaa aaaaaaaaaa atgcatattt
     9901 atcttagcaa aacgacgatt taaatcgtcg tttttttgta gtacgacggg catgtcgtat
     9961 atctgaggtg taagtcctcg gtgggcacct gctaccggtg aacccaatag cgattcccaa
    10021 gcctgactat cgtgaggtag cagggagagg aagggatagc gaaatcgtgg ctctacgaac
    10081 aggaacgtga tagtaaggcg tatatagcgg ataaggaggc ttcaaactct aaagtccaaa
    10141 aaggtagtcg taacctatat gtgtaaatca cgagagtaat tgaattcgga ctaaggtttg
    10201 tgtgaaaaag ataaatcttt ctagagtcta aagactctgc gtcagatttc ctattttcac
    10261 tgtaaccttt taacgtcctc atatcttgta taaacgagga aagatgtacg acttatcccg
    10321 tgaggtttca tgagcgctga aagcgtagta acaacgaatc atgagaagtc agccgagccc
    10381 atagtagtga ggaaacttct gtagtggaag tggagcgaag gggtgaatac tcaaacagtc
    10441 tggggagaga ctgtttgagg tctgtcgcta gaaagagaaa acgacagatc gaagtaatcc
    10501 tacttcactt gtgtctgtaa aatgagtggt ctgatagaac tggactttga cacgtaatga
    10561 ctagatgaag gttcaccaat ataagatgtc cctcaggcac caaaacaaga aaggaatacg
    10621 cacatgtcaa aactgctaga taagatatta tcacgcgaaa atatgctgga agcctacaat
    10681 caagtaaaat ccaataaagg ctcagctggg attgatggaa tgactatcga agagatggat
    10741 aattatctca gacaaaactg gcgcttgact aaggaactga taaaacagag aaaatataag
    10801 cctcaaccag ttcttaaagt tgagatacct aaaccagacg gaggcatccg tcaactagga
    10861 attccaacag ttatggatag aatgattcaa caggccattg tccaagtcat gagccccatt
    10921 tgtgaacccc atttctcaga tacgagttat ggtttcagac caaataggtc atgtgaaaaa
    10981 gccatcatga agctcttaga atacttaaat gacggctatg agtggatagt ggatatagac
    11041 ctagagaaat ttttcgatac agttcctcaa gatagattga tgtccttagt acataacatt
    11101 atcgaagacg gagatacgga atccttgatt cgtaagtatc ttcattcagg tgttatcatt
    11161 aatggtcaac gttataaaac actagttggt acaccacagg gaggaaattt atctcctctc
    11221 ttatccaata tcatgcttaa tgaattggac aaggaattag aaaagagggg acttcgattt
    11281 gtgcgctacg cagatgattg tgtgattacg gtcggaagcg aggcagcctc taagcgtgtg
    11341 atgtattcag tcagtcgttt tattgagaaa cggctaggtt tgaaagtaaa catgaccaag
    11401 actaagatta ccagaccaag agagttgaaa tatctaggtt ttgggttctg gaaatcatca
    11461 gatggttgga aaagccgtcc acatcaagat agtgttcgga gatttaagtt taaattgaag
    11521 aaactaacac agaggaaatg gagtatagac ctaacaagac gtattgagca actgaatttg
    11581 tctattcgag gatggataaa ctatttctca ttgggaaata tgaaaagtat agtcgccagc
    11641 atagatgagc gcttgcgtac tcgcctacga gtgattatct ggaagcaatg gaagaagaaa
    11701 tcgagacgat tatggggatt gcttaagtta gg
//
LOCUS       DAVHSO010000067        11618 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.068, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000067 DAVHSO010000000
VERSION     DAVHSO010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11618)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11618)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11618
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.068"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            133..387
                     /gene="blpM"
                     /locus_tag="VVR18_001872"
     CDS             133..387
                     /gene="blpM"
                     /locus_tag="VVR18_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpM"
                     /protein_id="HEU6033345.1"
                     /translation="MDTKIMEQFHEMDITMLSSIEGGKNNWQTNVLEGGGAAFGGWGL
                     GTAICAASGVGAPFMGACGYIGAKFGVDLWAGVTGATGGF"
     gene            403..606
                     /gene="blpN"
                     /locus_tag="VVR18_001873"
     CDS             403..606
                     /gene="blpN"
                     /locus_tag="VVR18_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpN"
                     /protein_id="HEU6033346.1"
                     /translation="MNTYCNINETMLSEVYGGNSGGAAVVAALGCAAGGVKYGRLLGL
                     WGAAIGGIGGAVVCGYLAYTATS"
     gene            850..999
                     /gene="blpO"
                     /locus_tag="VVR18_001874"
     CDS             850..999
                     /gene="blpO"
                     /locus_tag="VVR18_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="HEU6033347.1"
                     /translation="MDTKMMSQFAVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDG
                     CATTV"
     gene            1103..1222
                     /locus_tag="VVR18_001875"
     CDS             1103..1222
                     /locus_tag="VVR18_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="HEU6033348.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKIFSKSSKKDTDSTL"
     gene            2008..2391
                     /locus_tag="VVR18_001876"
     CDS             2008..2391
                     /locus_tag="VVR18_001876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HEU6033349.1"
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGV
                     FLLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHI
                     FIVFNALMYLLSSSQVSLKKNKLSS"
     gene            2443..3132
                     /locus_tag="VVR18_001877"
     CDS             2443..3132
                     /locus_tag="VVR18_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6033350.1"
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQMTLIIQNYWQFSSQIGNFV
                     WIQNFLSLLFSGVMIWILVKTGHGYLFHIPRKKWLWYSILTVLVVVLQISFNVQTAKH
                     VQSTAEGWAVLIGYSGTNFAELGIYITLFFLTPLMEELIYRGLLQHAFFKHSRFGLDL
                     LLPSILFALPHFSSLPSLLDIFIFATSGIIFASLTRYTKSIYPSYAVHVINNIFATLP
                     FLLTFLHRVLG"
     gene            3174..3422
                     /locus_tag="VVR18_001878"
     CDS             3174..3422
                     /locus_tag="VVR18_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033351.1"
                     /translation="MYKHLFFLDSKTLDWLTPYILVLASDTIAFNVFVLTFVSAVIFN
                     FLNPMLSLMAIFLGAGYVVGFWLLKWFVLERLELKDDV"
     gene            3452..4063
                     /locus_tag="VVR18_001879"
     CDS             3452..4063
                     /locus_tag="VVR18_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6033352.1"
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALILVSL
                     LVTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHL
                     AEVSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSN
                     VPSFIFYLLGGLLLGLAYKKSQNLWVSTLVHMFYNSWPLLYYL"
     gene            4225..5019
                     /locus_tag="VVR18_001880"
     CDS             4225..5019
                     /locus_tag="VVR18_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphotransferase family protein"
                     /protein_id="HEU6033353.1"
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGL
                     AREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQ
                     LSRLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDV
                     RHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTV
                     LSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            5016..5651
                     /gene="trmB"
                     /locus_tag="VVR18_001881"
     CDS             5016..5651
                     /gene="trmB"
                     /locus_tag="VVR18_001881"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HEU6033354.1"
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVE
                     VGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEAGVSNIKLLWVDGSDLTD
                     YFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFE
                     YSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            5778..6257
                     /gene="rimP"
                     /locus_tag="VVR18_001882"
     CDS             5778..6257
                     /gene="rimP"
                     /locus_tag="VVR18_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HEU6033355.1"
                     /translation="MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVD
                     KPEGITLNDTADLTEMISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGK
                     YIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL"
     gene            6301..7437
                     /gene="nusA"
                     /locus_tag="VVR18_001883"
     CDS             6301..7437
                     /gene="nusA"
                     /locus_tag="VVR18_001883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HEU6033356.1"
                     /translation="MSKEMLEAFRILEEDKGIKKEDIIDAVVESLRSAYRRRYGQSDS
                     VAIDFNEKTGDFTVYTVREVVDEVFDSRLEISLKDALAINSAYELGDKIKFEEAPAEF
                     GRVAAQSAKQTIMEKMRKQTRAITYNTYKEHEQEIMSGTVERFDNRFIYVNLGSIEAQ
                     LSKQDQIPGEVFASHDRIEVYVYKVEDNPRGVNVFVSRSHPEMIKRLMEQEIPEVYDG
                     TVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRGGANIKKITSKFHPARYDAKNDR
                     MVPIEENIDVIEWVADPAEFIYNAIAPAEVDQVIFDENDSKRALVVVPDNKLSLAIGR
                     RGQNVRLAAHLTGYRIDIKSASEFEAMEDAASVELEVENDTVEE"
     gene            7459..7752
                     /locus_tag="VVR18_001884"
     CDS             7459..7752
                     /locus_tag="VVR18_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HEU6033357.1"
                     /translation="MKTRKIPLRKSVVSNEVIDKRDLLRIVKNKEGQVFIDPTGKANG
                     RGAYIKLDNAEALEAKKKKVFNRSFSMEVEESFYDELIAYVDHKVKRRELGLE"
     gene            7745..8044
                     /locus_tag="VVR18_001885"
     CDS             7745..8044
                     /locus_tag="VVR18_001885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxQ-related RNA-binding protein"
                     /protein_id="HEU6033358.1"
                     /translation="MNKQKISNLLGLAQRAGRIISGEELVVKVIQDGKAKLVFLAHDA
                     GPNLTKKIQDKSHYYQVEIVTVFSTLELSIAVGKSRKVLAVTDAGFTKKMRSLME"
     gene            8061..10853
                     /gene="infB"
                     /locus_tag="VVR18_001886"
     CDS             8061..10853
                     /gene="infB"
                     /locus_tag="VVR18_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HEU6033359.1"
                     /translation="MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAA
                     KIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVA
                     AKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNR
                     RFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEER
                     FKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKK
                     QARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTP
                     KPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGET
                     IELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTL
                     LDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDIT
                     ILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTA
                     WGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAV
                     ATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGD
                     HFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADV
                     QGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQAR
                     QQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIG
                     GFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDI
                     KMDDVIEAYVMEEIKR"
     gene            11104..11454
                     /gene="rbfA"
                     /locus_tag="VVR18_001887"
     CDS             11104..11454
                     /gene="rbfA"
                     /locus_tag="VVR18_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HEU6033360.1"
                     /translation="MANHFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGD
                     LSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEY
                     GNKIDEMLRNLDKN"
BASE COUNT         3551 a         2035 c         2630 g         3402 t
ORIGIN      
        1 tgtaattttt gcaattcaag acgtttcgat gactattcaa gatctggatg aaaaatttta
       61 aaaaacgatg atatactaaa cttgtcaaag ttacaacaag acaaaaatta aaaataaaaa
      121 agagtatttg tcatggatac aaaaattatg gaacaatttc atgaaatgga tataactatg
      181 ttatctagta ttgaaggagg caagaataat tggcaaacta atgtcttaga aggtggtggt
      241 gctgcttttg gtggctgggg gctagggaca gctatttgtg ctgcgagtgg tgttggagca
      301 ccatttatgg gagcatgtgg atacatagga gctaaatttg gtgtggatct ttgggcagga
      361 gtaacagggg caacgggtgg attttaataa aaggagactt gtatgaatac ttattgtaat
      421 ataaatgaaa caatgctgag tgaggtttat ggaggtaatt ccggaggagc agctgtagtt
      481 gctgctttag gttgtgcagc gggtggagtg aaatatggga gacttctagg actatggggc
      541 gctgcaatag gaggaattgg aggagcagtg gtttgtggat atttagccta taccgctaca
      601 tcataaaaat gaaagctaaa ttttatgaag gctatattct ttattattct cttcgctttt
      661 caaacctatc ttatttatct atccataagt atctccgata aaaaacaaaa gactattgaa
      721 ttaacatcat tgaattgttt tgtcatatta tttctaatct atgataaatt aatttttctc
      781 tttattgcct atgttttttt gataattttt atattaaact tgttccgtaa ctgaaaagtg
      841 atatactata tggatacaaa aatgatgtca caatttgcag ttatggataa tgaaatgctt
      901 gcttgcgttg aaggtggaga tattgattgg ggaagaaaaa ttagttgtgc agcaggggtt
      961 gcatatggcg caattgatgg gtgtgcaaca acggtttgac atttctattg ggaccatttg
     1021 ctataggaat aggtgtaact ggtgctgcag gtggagctat acttggaggt gtagcctatg
     1081 cagcaatatg ttggtggtaa ttatggattt taaaagtttt attattggtt tagtagttgg
     1141 tatatttggt ccttatatgg atgacttaat tagaaaaata ttttcaaaat cttccaaaaa
     1201 ggatacggat agtactctct aaaaaataaa tttctcccct gtatttgcta gcttaattta
     1261 caggggagtt tctttaatat tgtttcgcct gtcaaaatga tatgtgatag caggatgaaa
     1321 agtctacaaa caagttggta tcaatacaat ataaagagga aagtatgttt ttaatgctta
     1381 ctttttaaat tttttaacaa ttcaagatgt ttcgatgaca attcaagatt tggatgaaaa
     1441 attttaaaaa acaatgatat actaaacttg tcaaagttgc aacgtgtgct gctacattat
     1501 gttaaaaatc gctcttgatt gataagctgg atttgttagg aaaggagtaa ataattatgg
     1561 ataagaaaaa gatagtttcg actataatat gtatagtatt tcttgtagtg tcagtagata
     1621 atttttttag agacttaacc ccgttactgt tcattttaaa tattattggc ctgtcttgct
     1681 tttcagtgct aacatacatt aacataaaag agatactctt aaatataagt aaatgatgat
     1741 ttggttagtc ctagaaccaa tcaacttatg tttatcggct tggcagattt tatgtttgtc
     1801 atttgtttgt atagaggtat ttcagaaaca gaattctatc aacaactaat cgcttatata
     1861 ggtgtattct ctgcttgttt atcacgcttc tgctcatgtg gggcttgaag tattataaaa
     1921 agtagctttc tatccttttc tgacaggata tttgagtaga aggctctatt aaattgttag
     1981 tgaaataaat gaatggaggt atttaatatg aaatacagat tattttttgt tattttcttg
     2041 agtagtgtgt tggatattct tttagggaca tttttacaaa tctctatcgt atctattggg
     2101 tggcttgttc tttacagtgg tttgtttgaa gcaggagttt tccttcttgc taataaaggg
     2161 gtggcggtaa aaatcaagga agtagatatt cgaaatcgct ttaaatttat ttttggaaaa
     2221 accttatggt ttcaaattct tttgctcatc tttttgataa tcaaacttta tcttggtttg
     2281 gatgcgaggt tgattttatt ctatggacat attttcattg tctttaatgc cttaatgtat
     2341 ctattatcta gtagtcaggt tagccttaaa aagaacaaac tgtcttctta atcttacagc
     2401 agtagagcct gacaaggtga ggtcatagta gggaggattt ctatgaaaaa gtatcaactt
     2461 ctattcaaaa taagtgcagt tttctcttac ttatttttcg tatttggtct ttctcagatg
     2521 acgcttatta ttcaaaatta ttggcaattt tcttcccaga ttggcaattt cgtctggatt
     2581 caaaatttct tgagtttgct atttagcgga gtcatgattt ggattctggt taagacaggt
     2641 catggttatc tctttcacat tccaagaaaa aaatggcttt ggtattcgat tttgacagta
     2701 ttagtggtag tgctccagat ctcttttaac gttcagacag ctaaacatgt tcagtcaact
     2761 gctgaaggtt gggctgtatt gatcggttat agtgggacca actttgctga gctaggtatc
     2821 tatataactt tgttctttct gactccactt atggaagagc taatctatag aggattactg
     2881 caacacgcct tttttaagca ttcgagattt ggccttgatt tgcttcttcc gtcaatttta
     2941 tttgctcttc ctcatttttc aagcctgcct agtttgttag atatcttcat ctttgcaaca
     3001 tctggcatca tctttgctag tttgacccgc tataccaaga gcatttatcc ttcctatgcg
     3061 gtgcatgtga tcaataatat tttcgcaaca ttaccatttt tgctgacttt tttacatagg
     3121 gtcttggggt aaaaaaacaa aaggcttgct tttcagccat agaggagatt atcatgtata
     3181 aacacttatt tttcctagat tccaaaacct tagactggtt gacgccctat attctagtct
     3241 tggcttctga caccattgcc tttaatgttt ttgtgctaac ctttgtgtct gcggtgatct
     3301 ttaatttcct gaatcccatg ctatctttaa tggctatctt cttaggggct ggctatgtgg
     3361 ttggattttg gttactaaaa tggtttgttt tggaaaggtt agagctaaag gatgacgtgt
     3421 aggaagtctg tttgttgagg aggataattt tatggagttt tttgataaat ttcatgcctt
     3481 gtgttttgga tttttagtac taataattgt cattacagtt ccttatacga ttaaccatgg
     3541 ggattttttt caaaatgaat ctgcattgat tcttgtaagt cttcttgtaa cctcgctgag
     3601 tgttgcttat gctagaaagt ttgaaatgat ttcttttggg atgttaagca agaaacaact
     3661 tttgcttttc attgcaatct ttcttctaag tgtacttgag acgctggttt atattcattt
     3721 cttcgctgtt tcttctggct caggggtcca acacttggcg gaagtcagca gaggaatttc
     3781 cctgtctttg attttgacta cctcagtttt tggccccatc caggaggaac tcattttcag
     3841 aggacttctt caaggtgcgg tttttgacaa ttcttggtta gggcttgtgc taacttcctc
     3901 tctcttttct ttcatgcatg gaccttctaa tgtcccttcg tttatttttt atctacttgg
     3961 gggcttgttg ctgggccttg cttataaaaa gagccaaaac ttatgggttt ctactctagt
     4021 ccacatgttt tacaacagtt ggccactcct atattattta taaaaattat gaaaaggtaa
     4081 gtaggagatt gtgcttacct ttttctttct ataatgataa cccaaaccac tccagaggct
     4141 tttctttgag aatcgggtta gagtggttga cgaataggcc aaaaactagt agaatagtaa
     4201 ggaaacttta tacggaggaa agaaatggat ttgggtgata atgagctaac actgactccc
     4261 atacctggga aaagtggcaa ggcttatatg ggtagctatc ctgatgggaa gcgcatcttt
     4321 gtaaaaatga acacctctcc aatcctacct ggtctagcta gagaacaaat tgctccacaa
     4381 ttattatgga gtcgtcgttt ggcagatggg cgtgatatgt gtgctcaaga atggttgaca
     4441 ggcaagatat tgacccccta tgatatgaat cgtaagcaaa tcgtcaatat tttaacccgt
     4501 cttcatcgct cacgtccgtt gatgacacaa ttgagtcgtt tgggctatgc catggaaaca
     4561 cctgtagatt tactacagtc ttggcaagaa acggctccag atgctttgcg taaaaatcat
     4621 tttatcagtg aagtgatggc tgatttacgt cagactattc caggatttag agaggaccat
     4681 gcgaccattg tccatggaga tgtacgacat agtaattgga ttgagacaga tagtggcttg
     4741 atttatttag tagattggga ttcggttcgc ttgaccgatc gcatgtttga tgtggcccat
     4801 atgctctgcc attatatttc agaacatcag tggaaggaat ggttgaccta ctacggttac
     4861 aagtacaatc aaacggtatt aagtaaattg tattggtatg gtcaattgtc ttatttgagt
     4921 cagatttcca agtattatat gaaccaagat ttagaaaatg tcaatcggga gattcatggt
     4981 ttgcgtcatt tccgagacaa gtatggaaag agaagatgag agttagaaat cgtaaagggg
     5041 caacagaatt actagaggca aatccccagt atgtggtcct caatcccttg gaagccaagg
     5101 caaaatggcg ggacttgttt ggcaatgata atcccattca tgtggaagtt ggaagtggaa
     5161 agggtgcctt tgtttcaggt atggccaagc aaaaccctga catcaactat atcgggattg
     5221 atattcaaaa gtctgttttg agctacgctt tggacaaggt gcttgaagct ggagtgtcta
     5281 acatcaagct cttgtgggta gatggttctg acttgactga ctattttgaa gacggtgaga
     5341 ttgatcgctt gtatctgaac ttttcagatc cttggcctaa aaaacgccat gaaaagcgtc
     5401 gtttgactta caagaccttc ttggatacct tcaagcgtat cttgcctgaa aatggagaaa
     5461 ttcatttcaa gacggataac cgtggcttgt ttgagtatag cctagtgagc ttttctcaat
     5521 atggcatgaa actcaatggt gtctggctag atttgcatgc cagtgatttt gaaggcaatg
     5581 tcatgacaga atacgagcaa aaattctcca acaaggggca agttatctac cgagttgagg
     5641 cagaatttta agaaatagcc tgaaatcagg ctgtataagt gcttttgctt tacataagtt
     5701 agcaaatgtg ctatactaag ggtaagaata tgagaaagag aggcggggaa atatcttcgc
     5761 ctcttgctta tgaggaggtg gacgcaatcg caacaatcgt agaattagtc agagaagttg
     5821 tagaacctgt catagaagct cctttcgaac tcgtggatat cgagtatgga aagattggca
     5881 gtgacatgat tctcagtatt tttgtagata aacctgaagg aattaccttg aacgacacgg
     5941 cagacttgac agaaatgatc agtcctgtcc tagacaccat caagccagat cccttcccag
     6001 aacaatattt cctagaaatt accagtccag gcttggaacg tcctttgaaa accaaggatg
     6061 ccgtcgctgg agcggttggg aaatacatcc atgtcgggct ctaccaagcc atcgataagc
     6121 aaaaggtctt tgaaggaacc ttgttggcct tcgaagagga cgagttgact atggaatata
     6181 tggacaagac acgtaagaaa actgtccaaa ttccatatag tttagtatca aaagcacgtt
     6241 tagcagttaa attatagaaa aagaaaggat agcttttgag gattcaaaag tgaagaaaac
     6301 atgagtaaag aaatgctaga ggccttccgc attttggaag aagacaaggg aatcaaaaaa
     6361 gaagacatca tcgacgcagt agtagagtcg cttcgttccg cttatcgcag acgctatggt
     6421 cagtcagaca gcgtagctat tgacttcaac gaaaaaacag gtgactttac agtttatact
     6481 gtccgtgaag ttgttgatga agtatttgat agccgtttgg aaatcagctt gaaagatgct
     6541 cttgccatta attcagctta tgaacttgga gacaaaatca agtttgaaga agcaccagct
     6601 gagtttggtc gtgtagcagc ccaatctgcc aaacaaacca tcatggaaaa aatgcgcaag
     6661 caaacacgtg ccatcactta caatacttac aaagaacatg agcaagaaat catgtctggt
     6721 acagtagaac gctttgacaa ccgctttatc tatgtcaacc ttggtagcat cgaagcccaa
     6781 ttgtcaaaac aagaccaaat tcctggagaa gtttttgctt ctcatgatcg tatcgaagtt
     6841 tatgtttaca aggttgaaga caaccctcgt ggtgtgaacg tctttgttag ccgtagccat
     6901 ccagaaatga tcaaacgttt gatggagcaa gaaattccag aagtttatga tggaactgtt
     6961 gaaatcatga gcgtggctcg tgaagcaggt gaccgtacga aggttgctgt tcgtagccac
     7021 aatccaaacg tagatgctat cggtacaatc gttggacgtg gtggtgctaa tatcaagaag
     7081 attactagca aattccaccc agctcgttac gatgctaaaa atgaccgcat ggtaccaatc
     7141 gaagaaaata tcgatgttat cgagtgggta gcagatccag ctgaatttat ctacaatgcc
     7201 atcgctcctg ctgaggttga ccaagttatc tttgatgaaa acgacagcaa acgtgccttg
     7261 gtggttgttc cagataacaa gctttctctt gccattggtc gtcgtggaca aaacgtgcgc
     7321 ttggcggctc acttgactgg ttatcgtatc gatatcaagt ctgctagcga atttgaagcc
     7381 atggaagacg ctgcttcagt agagttggaa gtagaaaacg atactgtaga agaataaaag
     7441 ctgctagagg agggaaagat gaaaacaaga aaaatccctt tgcgcaagtc tgttgtgtct
     7501 aacgaagtga ttgataagcg tgatttgctc cgcattgtca agaacaagga aggacaagtc
     7561 tttattgatc ctacgggcaa ggccaatggc cgcggcgctt atatcaaact agacaatgca
     7621 gaagccctag aggcgaaaaa gaagaaggtc tttaaccgca gctttagcat ggaagtggaa
     7681 gaaagctttt atgacgagtt gatcgcttat gtggatcaca aagtgaaaag aagagagttg
     7741 ggacttgaat aagcaaaaga taagtaatct cttggggctt gctcagcgag cagggcgcat
     7801 catatcgggt gaagaattgg tggtcaaggt cattcaagac ggcaaggcca agttggtctt
     7861 tctagctcat gatgctggac ccaatctgac caagaagatt caagataaaa gtcattatta
     7921 tcaagtagaa attgtaaccg tgttttcaac actggaatta agcatagcag tcgggaaatc
     7981 gagaaaggtt ttggctgtaa cagatgctgg atttacaaag aaaatgaggt ctcttatgga
     8041 atagaagagg aggacatgat ttgtctaaga aaagattgta cgaaatcgca aaagaacttg
     8101 gaaaagaaag taaagaagtt gtagcgcgtg caaaagagtt gggcttggat gtgaaaagcc
     8161 actcatcaag tgtggaagaa gctgtcgctg caaaaattgc tgccagcttt aagcctgcag
     8221 ctgctccgaa agtagaagca aaacctgcag caccaaaagt aagtgcagaa aagaaagccg
     8281 aaaaatctga gccagctaaa ccagctgtag ctaaggaaga ggcaaaaccg gctgagccag
     8341 ttgctccgaa aacagaaaaa gtagcagcga aaccgcaaag tcgtaatttc aaggctgagc
     8401 gtgaagcccg tgctaaagag caggcagaac gacgcaagca aaataagggc aataaccgtg
     8461 accaacaaca aaacggaaac cgtcagaaaa acgacggccg taatggtgga aaacaaggtc
     8521 aaagcaaccg cgacaatcgt cgctttaatg accaagctaa gaagcagcaa ggtcagcaaa
     8581 aacgtagaaa tgagcgccgt cagcaagagg ataaacgttc aaatcaagcg gctccacgta
     8641 ttgactttaa agcccgtgca gcagccctaa aagcagagca aaatgcagag tacgctcgtt
     8701 caagtgagga acgcttcaag cagtatcagg ctgctaaaga agccttggct caagctaaca
     8761 aacgcaagga accagaggaa atctttgaag aagcggctaa gttagctgaa caagcacagc
     8821 aagttcaagc agtggttgaa gtcgtccctg agaaaaaaga acctgcagtg gatacacgtc
     8881 gtaaaaaaca agctcgacca gacaaaaatc gtgacgatta tgatcatgaa gaagatggtc
     8941 ctagaaaaca acaaaagaat cgaagtagtc aaaatcaagt gagaaatcaa aagaatagta
     9001 actggaataa caacaaaaag aacaaaaaag gcaataacaa gaacaaccgt aatcagactc
     9061 caaaacctgt tacggagcgt aaattccatg aattgccaac agaatttgaa tatacagatg
     9121 gtatgaccgt tgcggaaatc gcaaaacgta tcaaacgtga accagctgaa atcgttaaga
     9181 aacttttcat gatgggtgtc atggccacac aaaaccaatc cttggatggg gaaacaattg
     9241 aactcctcat ggtggattac ggtatcgaag ccaaacaaaa ggttgaagtg gataatgctg
     9301 acatcgaacg tttctttgtc gaagatggtt atctcaatga agatgaattg gttgagcgtc
     9361 caccagttgt tactatcatg ggacacgttg accacggtaa aacaaccctt ttggatactc
     9421 ttcgtaactc acgtgttgcg acaggtgaag caggtggtat tactcagcat atcggtgcct
     9481 accaaatcgt ggaaaatggt aagaagatta ccttccttga tacaccagga cacgcggcct
     9541 ttacatcaat gcgtgcgcgt ggtgcttctg ttaccgatat tacgatcttg gtcgtagcgg
     9601 cagatgacgg ggttatgcct cagactattg aagccatcaa ccactcaaaa gcagctaacg
     9661 ttccaatcat cgtagctatt aacaagattg ataaaccagg tgctaaccca gaacgcgtta
     9721 tcggtgaatt ggcagagcat ggtgtgatgt caaccgcttg gggtggagat tctgaatttg
     9781 ttgaaatctc ggctaaattt aaccaaaata tcgaagaatt gttggaaaca gtccttcttg
     9841 tggctgaaat ccaagaactc aaagcagacc caacagtgcg tgcaatcggt acggttatcg
     9901 aagcgcgctt ggataaagga aaaggtgcgg tcgcaaccct tcttgttcaa caaggtacct
     9961 tgaatgttca agacccaatc gttgtcggaa ataccttcgg tcgtgtccgt gctatgacca
    10021 acgaccttgg tcgtcgtgtt aaagttgctg gaccatcaac accagtctct atcacaggtt
    10081 tgaacgaagc accgatggcg ggtgaccact ttgccgttta cgaggatgaa aaatctgcgc
    10141 gtgcagcagg tgaagagcgt gccaaacgtg ccctcatgaa acaacgtcaa gctacccaac
    10201 gtgttagcct tgaaaacctc tttgataccc ttaaagctgg ggaactcaaa tctgttaatg
    10261 ttatcatcaa ggccgatgta caaggttctg ttgaagccct ttctgcctca cttcaaaaga
    10321 ttgacgtgga aggtgtcaaa gtgactatcg tccactcagc ggtcggtgct atcaacgaat
    10381 cagacgtgac ccttgccgaa gcttcaaatg cctttatcgt tggtttcaac gtacgcccta
    10441 caccacaagc tcgtcaacaa gcagaagctg acgatgtgga aatccgtctt cacagcatta
    10501 tctacaaggt tatcgaagag atggaagaag ctatgaaagg gatgcttgat ccagaatttg
    10561 aagaaaaagt tattggtgaa gcggttatcc gtgaaacctt caaggtgtct aaagtgggaa
    10621 ctatcggtgg atttatggtt atcaacggta aggttgcccg tgactctaaa gtccgtgtta
    10681 tccgtgatgg tgtcgttatc tatgatggtg aactcgcaag cttgaaacac tataaagacg
    10741 acgttaagga agttacaaac ggccgtgaag gtggattgat gatcgacggc tacaatgata
    10801 ttaagatgga tgatgtgatt gaggcgtatg tcatggaaga aatcaagaga taagattttt
    10861 tgctcctttc ttaggtggtg agggacgcaa gcaaaccgat ggtttcattg cttatttttg
    10921 agcctagggt ctcaaaaatc ccctgtgatg ggactgataa atcagttcca tcactttcac
    10981 cacggcgaaa gaagcagatg acttcaaatt gaacttcgtt tcaatttaaa ctgaaaatca
    11041 agaagtttaa aatagctagg tctgctggcc tagcttttgg ttcaaagtag agaaaggaat
    11101 atcatggcaa atcatttccg tacagatcgt gtgggcatgg aaatcaagcg tgaagtcaat
    11161 gagattttgc aaaagaaagt ccgtgatcca cgtgtccaag gtgtgaccat cacagatgtt
    11221 cagatgctgg gtgacttgtc tgttgccaag gtttattaca ccattttgag taaccttgct
    11281 tcggataacc aaaaagccca aatcgggctt gaaaaagcaa ctggtaccat caaacgtgaa
    11341 cttggtcgca atttgaaatt gtacaaaatc ccagatttga ccttcgtcaa agacgagtcc
    11401 atcgagtatg gaaacaagat tgacgagatg ctacgcaatc tggataagaa ctaaagaaga
    11461 ggggttgccc ctctttttcg gctctttgtc aactgtagtg ggttgaagaa aagctaagct
    11521 cgagaaagga caaatttcgt cctttctttt ttgatattca gggcgataaa aatccgtttt
    11581 ttgaagtttt caaagttccg aaaaccaaag gcattgcg
//
LOCUS       DAVHSO010000068        11616 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.069, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000068 DAVHSO010000000
VERSION     DAVHSO010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11616)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11616)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11616
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.069"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(381..1577)
                     /gene="tuf"
                     /locus_tag="VVR18_001888"
     CDS             complement(381..1577)
                     /gene="tuf"
                     /locus_tag="VVR18_001888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEU6033361.1"
                     /translation="MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSV
                     NQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQM
                     DGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDL
                     LSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPV
                     EDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAG
                     DNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQ
                     FYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGM
                     VTEIEA"
     gene            complement(2499..3368)
                     /locus_tag="VVR18_001889"
     CDS             complement(2499..3368)
                     /locus_tag="VVR18_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000348128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEU6033362.1"
                     /translation="MDFTWALKYATEFLGTAILIILGNGAVANVELKGTKGHQSGWIV
                     IAVGYGMGVMIPALMFGNVSGNHINPAFTLGLAVSGLFPWAQVVPYIIAQVLGAIFGQ
                     ALVVATYRPFYLKTEKPNNILGTFSTISSIDHGTKESRYAATVNGLINEFVGSFVLFF
                     AALGLTKNFFGAEVLQFMKQKAIEAGQTVDFSDLAIKAQVAPHTASGLSVAHLALGFL
                     VMALVTSLGGPTGPALNPARDLGPRLLHAFLPKSVLGEHKGDSKWWYSWVPVVAPIAA
                     AIAAVAVFKFLYL"
     gene            complement(3591..4112)
                     /locus_tag="VVR18_001890"
     CDS             complement(3591..4112)
                     /locus_tag="VVR18_001890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU6033363.1"
                     /translation="MVPKTATSTETKTITRIIHYVDKVTNQNVKEDVVQPVTLSRTKT
                     ENKVTGVVTYGEWTTGNWDEVISGKIDKYKDPDIPTVESQEVTSDSSDKEITVRYDRL
                     STPDKPTPEPGTPKTETPVNPDPEVPTYETGKREELPNTGTEANATLASAGIMTLLAG
                     LGLGFFKKKEDEK"
     gene            complement(4070..5149)
                     /locus_tag="VVR18_001891"
     CDS             complement(4070..5149)
                     /locus_tag="VVR18_001891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MucBP domain-containing protein"
                     /protein_id="HEU6033364.1"
                     /translation="MNIILIAKPLRENTNTKANALNNGWARSGSEEFKKFSHFVGVDK
                     GIVRTNVLTGKKLSDKIRKEVGSGDSKLGKGGYFSTGDVLLGKDVVSYTVQVFSENNE
                     RVGVNTQSHRVQYNLPILADFSVIQDTVEPSRTVIEKIIPKLNIPEEEKKKKTSELAE
                     LISENVKVRYVDEQGRLLSLKNNTGIGEKESDGTYITNKKQLIGTSYNVTDKKLSSMT
                     TTDGKYYTFKEADTNSASLTGNIVSEGRTVTLVYRESEAPITATVTANYYKEGRQEKL
                     AESVIKADLAIGSEYTTESKTIEGKTTTEDKEDRVITRKTTYTLVATPANAYQKTVQQ
                     LTITTVRMLRKQWFPKQQPLLRRRL"
     gene            complement(5260..5514)
                     /locus_tag="VVR18_001892"
     CDS             complement(5260..5514)
                     /locus_tag="VVR18_001892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033365.1"
                     /translation="MLNVDQDFMSISKSNKSGSDWKKTFTVRITNRLANDLNNVLKQA
                     DKDTPNTPTWLNSAASKAKDDDRAYKLLKTLIPGENYLSC"
     gene            complement(5872..6405)
                     /locus_tag="VVR18_001893"
     CDS             complement(5872..6405)
                     /locus_tag="VVR18_001893"
                     /inference="COORDINATES: protein motif:HMM:NF024751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HEU6033366.1"
                     /translation="MTSFKEQEPEKVAEFLDILDNLKDLPIVYIDETGIDRYLYRPYA
                     GAPRGEKVYEKISGRRFERTSIVAGQVDGEFIAPMIYKKSMTSDFFVEWFKTQLLPAL
                     KTPHVIVMGNASFHPKNILDELCIQDKHFFLPLPPYSPDLNPIEQAWAILKKKVTDLL
                     REVPTIFECLECFFKTR"
     gene            complement(6392..6607)
                     /locus_tag="VVR18_001894"
     CDS             complement(6392..6607)
                     /locus_tag="VVR18_001894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033367.1"
                     /translation="MGKERREQGHIERKKRVVKNRKIPLEELKAFVEAHPDAFLREIA
                     AHFDCAVPSVWAALKQIKVTLKKDDEL"
     gene            complement(6574..6717)
                     /locus_tag="VVR18_001895"
     CDS             complement(6574..6717)
                     /locus_tag="VVR18_001895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tnpB"
                     /protein_id="HEU6033368.1"
                     /translation="MAYSTDFKQRALDSIKEGHSHVEAAKFFGVGVRTLFTWEKKDVN
                     KDT"
     gene            6951..8669
                     /locus_tag="VVR18_001896"
     CDS             6951..8669
                     /locus_tag="VVR18_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HEU6033369.1"
                     /translation="MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGT
                     AGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFE
                     SAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
                     GQMPPHDADALTTYIRAIENPFAVEVADVEIEKASGLIEVIGEAVDIEYLKEVKDINI
                     NPALIEEFGKDMKIVYTPLHGTGEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSP
                     NPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAK
                     YILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEE
                     KHNHTYMMGFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKE
                     YGYYAEKTISVTLSGVDGAEQIKAIMAKFRNNAPTEWNATAITVVEDFKAQTATVADG
                     TVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKIANIEAE
                     INAFVK"
     gene            8780..9127
                     /locus_tag="VVR18_001897"
     CDS             8780..9127
                     /locus_tag="VVR18_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEU6033370.1"
                     /translation="MEQFLDNIKDLEVTTVVRAQEALDKKETATFFIGRKTCPYCRKF
                     AGTLSGVVAETKAHIYFINSEEPSQLNDLQAFRSRYGIPTVPGFVHITDGQINVRCDS
                     SMSAQEIKDFAGL"
     gene            complement(9394..10227)
                     /locus_tag="VVR18_001898"
     CDS             complement(9394..10227)
                     /locus_tag="VVR18_001898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6033371.1"
                     /translation="MKKWMLVLVSLMTALFLVACGKNSSETSGDNWSKYQSNKSITIG
                     FDSTFVPMGFAQKDGSYAGFDIDLATAVFEKYGITVNWQPIDWDLKEAELTKGTIDLI
                     WNGYSATDERREKVAFSNSYMKNEQVLVTKKSSGITTAKDMTGKTLGAQAGSSSYADF
                     EANPEILKNIVANKEANQYQTFNEALIDLKNDRIDGLLIDRVYANYYLEAEGVLNDYN
                     VFTVGLETEAFAVGARKEDITLVKKINEAFSSLYKDGKFQEISQKWFGEDVATKEVKE
                     G"
     gene            complement(10240..10869)
                     /locus_tag="VVR18_001899"
     CDS             complement(10240..10869)
                     /locus_tag="VVR18_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU6033372.1"
                     /translation="MLELRNINKVFGDKQILSNFSLSIPEKQILAIVGPSGGGKTTLL
                     RMLAGLETIDSGQIFYNGQPLELDELQKRNLLGFVFQDFQLFPHLSVLDNLTLSPVKT
                     MGMKQEEAEKKASGLLEQLGLGGHAEAYPFSLSGGQKQRVALARAMMIDPEIIGYDEP
                     TSALDPELRLEVEKLILQNRELGMTQIVVTHDLQFAENIADVLLKVEPK"
     gene            complement(10879..11520)
                     /locus_tag="VVR18_001900"
     CDS             complement(10879..11520)
                     /locus_tag="VVR18_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU6033373.1"
                     /translation="MSYLFEILPSLLNGASTTVQVFALVLLFSIPLGVLIAFALQVHW
                     KPLHYLINIYIWVMRGTPLLLQLIFIYYVLPSIGIRLDRLPAAIIAFVLNYAAYFAEI
                     FRGGIDTIPRGQYEAAKVLKFSPFDRVRYIILPQVTKIVLPSVFNEVMSLVKDTSLVY
                     ALGISDLILASRTAANRDASLVPMFLAGAIYLILIGIVTIISKKVEKKYSYYR"
BASE COUNT         3421 a         2441 c         2104 g         3650 t
ORIGIN      
        1 actattgtat aatgcttttt gatttgagtc tagtattata ctcttcgaaa atctcttcaa
       61 accgcgtcag cttcgccttg tcgtatagat gttactgact tcgtcagttc tatctacaac
      121 ctaaaaacag tgttttgagc agtctgcagc taactttcta taacaaaatg aaataagaac
      181 aagacaaatc aatcaagaca atcaaatcga tttctaacaa tgttttagaa gtagatgtgt
      241 actattctag tttcaatata ttatagtttg ctctttgatt ttcattgagt attagttcaa
      301 tatctaaaaa aagaaccttg ccaagcaaga ttcttttagt gtctgactta aataattgtt
      361 cttctgggaa ctaaatcgaa ttaagcttcg atttctgtaa ccatacctga accaacagta
      421 cgtccaccct cacggataga gaatgtagta ccttgttcta cggcgattgg gtgaatcaac
      481 tcaacgtcga ttgtcacgtt atcaccaggc attaccattt cagtacctgc tggaagttcg
      541 attgaacctg taacgtcagt agtacggaag tagaattgtg gacggtagtt gttgaagaat
      601 ggagtgtgac gtccaccttc ttctttagta aggatgtaga cttcaccttt gaatttagtg
      661 tgtgggttga ttgaacctgg tttagcgata acttgtccac gttcgatttc atcacgttga
      721 acaccacgaa gaaggacacc tacgttatct ccagcaagac cttcgtcaag ttgtttacgg
      781 aacatttcaa caccagtaac aactgctttt tgagtttctt ctttgatacc aacgatttcg
      841 atttcgtcgt tgactttaac gataccacgg tcgatacgtc ctgaagcaac tgtaccacgt
      901 ccagtgattg agaatacgtc ctcgactgga agaagcaatg gtttgtcagt gtcacgttct
      961 ggttctggga tatactcatc aactgtgttc atcaattcca taacgatgtc ttcgtattta
     1021 gagtcacctt caagagcttt aagtgctgaa ccttggataa ctggaagatc gtcacctggg
     1081 aagtcgtatt ctgacaatag gtcacggatt tccatttcaa ccaattcaag caattcttcg
     1141 tcgtcaacca agtcaacttt gttcatgaag acgataaggt gtttaacacc aacctgacgt
     1201 gaaagaagga tgtgctcacg agtttgtggc attggtccgt cagttgaagc tactacaagg
     1261 atagctccgt ccatttgagc agcaccagtg atcatgtttt taacgtagtc cgcgtgtcct
     1321 ggagcgtcga tgtgagcgta gtgacgtttt tcagtttcgt actcaacgtg cgcagtgttg
     1381 atagtgatac cgcgttcgcg ttcttctgga gcagcatcga tagacgcata gtctttaggt
     1441 tggttaactg atgaaggcaa gcgacgtgcc aaaacagttg tgatagctgc agttagggta
     1501 gttttaccgt ggtcaacgtg tccgatagta ccaatgttaa cgtgtggttt actacgatcg
     1561 tatttttctt ttgccatttg agtaaaagcc tccaataaaa tatattttat agatagacag
     1621 taggcaatac agtctaactt tccttactat tttatcaaat ttcagctaaa ttgcaagtgt
     1681 tttacaacgt ttttgtgaat tattcttggt aaaaatttaa ctaattaata gaaagtacta
     1741 aatagactta tccttcaagg agttttcagc attatccatc cactcacttg ctgaaaatgt
     1801 aaacagtctc tggtttatat agtaaaatga aacaagaata gggcaaatcg atcaggacag
     1861 tcaaatcgat ttctaacaat gttttagaag tagatgtgta ctattctagt ttcaatctac
     1921 tatacaacct caaaactgtg ttttgaacaa cctgcggcta gcttcttagt ttgccctttg
     1981 attttcattg agtataaaat tgcagataaa acgataacaa tcataggact cagcagagtc
     2041 aatgtaggtc gaagaatagc ccccctaatc gcttatttta tagcaaaatg aaatagaaac
     2101 tgaacatttt gttgaggaag gtaaatcaat tcctcacaat gtttgagaaa gaagggagga
     2161 ctattccaac ttcaacccac tataaagcag acttacaaga tagggaaccc atctccgata
     2221 atattccgat aatatatagt agaatgaaaa ctgcacaatt tgattggaga attcaaacca
     2281 atttctaaca atgttttaga aacaagggtc tattatttca actgcaacct actatagccc
     2341 attgaagctg gaatagccca ctgagacttc taaaccactg ctggagagga gtttgtttag
     2401 agtttctttc atttccctaa aaaatcaaaa agagagaacc agtctgatcc tctcttactt
     2461 atagatggtg ctcactcaaa tgttaaagga gctatttctt agagataaag gaatttgaat
     2521 acagctactg ccgcaattgc tgctgcgata ggtgctacta ctggtaccca agaataccac
     2581 cattttgaat cgcctttatg ctcaccaaga actgattttg gaaggaaagc atgaaggaga
     2641 cgtggtccca agtcacgggc tgggttcaag gcaggtcctg taggtcctcc aagtgatgtt
     2701 accaaagcca taacgaggaa tccaagtgcc aagtgagcca cagaaagtcc tgaagcagtg
     2761 tgtggagcca cctgtgcttt aatagccaag tcagaaaaat caactgtttg tcctgcttct
     2821 attgcctttt gtttcatgaa ttgaagcact tcagcaccaa agaagttttt agtcaaacca
     2881 agagctgcaa agaacaaaac aaatgaacca acaaactcat taatcaaacc attgacagtt
     2941 gctgcatagc gactttcttt tgtaccatgg tcaatacttg aaatagttga gaaagttccc
     3001 aagatgttat ttggtttttc agttttcaag tagaatggac ggtatgttgc cacaactaag
     3061 gcttggccaa agatagcccc caagacttgc gcgataatgt aaggtaccac ttgtgcccaa
     3121 gggaaaagac cgctaactgc aagccctaga gtgaaagcag ggttgatgtg attcccagat
     3181 acgttaccaa acatcaaggc tgggatcata acccccatac cataaccaac agcgatgacg
     3241 atccagccac tttggtgacc tttcgtacct ttaagttcaa cgttggcaac tgcaccattc
     3301 ccaagaatga tcaaaatggc agttcccaaa aattcagtgg catacttcag tgcccatgtg
     3361 aaatccattt gctagattct ccttaaaatt ttttagatat tccttatttt atcaattttt
     3421 accctattta gcaactgatt tctggaaata tttttaaaaa aataggattc atagtttccc
     3481 agttcaacgt acttgtaagc gtttttattc ttcacgaaag acctcattct caaaaccagg
     3541 aaaaagccca catctatgag cttttcctgg ttcctagatt ctaaaatcta ttatttttca
     3601 tcttcttttt tcttgaagaa tcctaatcct agaccagcta acaaggtcat gataccagca
     3661 ctagccaagg tagcattagc ttctgtacct gtgtttggca attcctctct cttacctgtc
     3721 tcataagtcg gaacttctgg gtctggattc actggagttt cagtttttgg agtacctggt
     3781 tctggagttg gtttatctgg tgttgataaa cggtcatacc ttaccgttat ttctttatca
     3841 ctagagtctg acgtaacttc ttgtgattca actgttggaa tatctggatc tttgtacttg
     3901 tcaatcttac cagatataac ctcgtcccag tttcctgttg tccattcacc gtaggttaca
     3961 actcccgtga ccttgttctc agtttttgta cggcttaagg ttacaggttg aacaacatct
     4021 tcttttacat tttggttcgt aactttatca acgtaatgaa tgatacgcgt tatagtcttc
     4081 gtctcagtag aggttgctgt tttgggaacc actgtttcct caacattctc acggtagtaa
     4141 tagtcaactg ttgcaccgtc ttctggtacg catttgcagg agttgctacc aaggtgtatg
     4201 ttgttttcct tgtgataact cggtcttctt tgtcctcagt tgttgttttc ccttcaatag
     4261 tttttgattc tgtggtatac tcagaaccta tcgctaaatc agcttttata acagactctg
     4321 ccaacttctc ttgcctacct tctttatagt aattggctgt tactgtagca gtgattggcg
     4381 cttcgctttc tctataaact aaggtcactg ttctaccttc gcttacaata ttcccagtta
     4441 aacttgcaga atttgtatct gcttctttaa aagtataata ttttccgtca gtagtagtca
     4501 tgctactgag ttttttatct gtgacattat agctggtacc aatcagttgt tttttattgg
     4561 taatgtaggt tccgtcactt tctttttctc caattccagt attatttttc aatgatagca
     4621 aacgcccttg ttcatcaaca tagcgaactt tcacattttc tgagattagt tctgccaatt
     4681 ctgaggtttt tttctttttc tcttcttcgg gaatatttag ttttggaatg attttttcaa
     4741 taacggttcg tgatggttcc acagtatctt ggatgactga aaagtcagct agaattggga
     4801 gattatactg aacacggtga ctttgagtgt ttactcctac tctttcatta ttctctgaaa
     4861 atacttgtac ggtataagaa acaacatctt ttcctaatag aacatcccca gtagagaaat
     4921 agccgccttt tcctagtttg ctatctccag agcccacttc tttcctaatc ttatcagata
     4981 gttttttacc agtcagtaca ttcgttcgca caatcccttt gtctacccct acaaagtggg
     5041 agaatttttt gaactcttca gaaccagatc tagcccaacc attattaagg gcatttgctt
     5101 ttgtatttgt attctctctc aaaggtttgg cgattagaat tatattcatc ggcgcttaga
     5161 gttgctgcta tatctgactc ttgaatacca acttccttac taccatttct agcggcagta
     5221 tatgtgtatt tatctgtttc tacttctagc tgattatcct taacatgata ggtaattttc
     5281 tcctggtata agagtcttca gtagtttata tgctctgtca tcatctttag ctttagaagc
     5341 agctgagttt agccaagttg gggtattagg agtatcttta tcagcctgtt tcaagacatt
     5401 attcaagtca tttgctagcc tattggttat cctcactgtg aaagttttct tccagtctga
     5461 accactttta ttagacttag atatgctcat gaaatcctgg tcaacattca acacaatatc
     5521 gccttgtttt ttagcatctt ccgttgcttc tgcttcaaat tgatcatgga gtttttgttg
     5581 ctctggtgta tagttttttt atttacacga tttaatgtac tattttttat tttagtatta
     5641 agaactccat taatacgatt tttaaattct gcttcaaaaa atcccttaat ttgttggtgc
     5701 gcaagttcaa cattcaaacc tttcttatac aagtcttcat tctgatacaa gtcttcattc
     5761 tgaacgattt cggctacacg gtgaatggtt tgattgtata ccgtcttctc ttaaccagca
     5821 gtatccttag ttttaatgac tactcgatag gttcctttag aaccgttata gtcatctagt
     5881 tttaaaaaag cattccaaac attcaaaaat agttggaact tcccttaata aatccgtcac
     5941 tttctttttc aagatagccc aagcttgctc aataggattc aaatccggtg aataaggtgg
     6001 tagaggtaag aaaaagtgtt tatcttggat gcagagttca tccaaaatgt tcttgggatg
     6061 aaaactagca ttgcccatga caataacatg aggtgtcttc aaagcaggta ggagttgcgt
     6121 tttgaaccac tccacaaaga aatcgcttgt catgcttttc ttgtaaatca tgggagctat
     6181 aaactctccg tctacttgtc ctgcaacaat tgaagttcgc tcaaaacgac gtccgctaat
     6241 cttttcatag actttctccc ctctaggagc ccctgcataa ggacgataga ggtagcggtc
     6301 gattcctgtt tcgtcaatat atacgattgg taaatctttt aggttatcca aaatatcaag
     6361 aaactcagcg actttctctg gctcttgttc cttaaagctc gtcatctttt tttaaagtga
     6421 ccttaatctg ctttaaagct gcccatactg aaggaacagc acaatcaaaa tgtgccgcaa
     6481 tttcccgtaa aaaagcatct ggatgagcct ctacaaaggc tttcaattcc tctaaaggaa
     6541 tctttcggtt tttgacgact cgctttttcc tctctatgtg tccttgttca cgtctttctt
     6601 ttcccacgtg aagagagttc tgacgccaac accaaaaaac ttggctgcct cgacatgact
     6661 gtgcccctct ttgatggaat ctaatgctcg ctgtttaaaa tcagtactat atgccatagc
     6721 tttattataa catgtatttt ataaactaag ctactatatc aatgttttgt tatgagaaga
     6781 cttacttttt ttactgaaat tgaatttttc ctagcctcaa catcatataa ccccaaaatt
     6841 caatctgacc tggtttgaag agatgttcga agcagataag gttttactaa aactaaaaaa
     6901 aatgatataa tcaaactgat taaatgtttt aaaactaaag gagaatttga atgtcttacc
     6961 aagaaaatta ccagaaatgg gttgattttg tggagcttcc tgactacctt cgtcaagatt
     7021 tggaaaatat ggacgaaaaa actaaggaag atgccttcta tacaaatctt gaatttggta
     7081 ctgcaggtat gcgtggcttg gttggtgctg gtacaaaccg tatcaacatc tacgttgttc
     7141 gccaagctac tgaaggattg gctcgtttga ttgagtcaaa aggtggaaac gagaaagaac
     7201 gcggtgtagc aattgcctac gatagccgtc acttctcacc tgagtttgcc tttgaatctg
     7261 cggcagttct tgctaaacac ggcatcaaat cttacgtatt tgaaagcctt cgtccgactc
     7321 cagaactatc atttgcagtt cgtcatctca actgtttcgc aggtatcatg gtcacagcca
     7381 gccacaaccc tgctccattt aacggttaca aggtttacgg tgaagacggt ggacaaatgc
     7441 ctccacacga tgcggacgct ttgactactt atatccgtgc aatcgaaaac ccatttgcag
     7501 ttgaagttgc tgatgtggaa attgaaaaag cttctggctt gattgaagtt atcggcgaag
     7561 ctgttgacat agaatacctt aaagaggtta aggacataaa catcaaccca gccttgattg
     7621 aagaatttgg taaagacatg aagattgtct acacaccact tcatggtact ggtgaaatgt
     7681 tggctcgtcg tgctcttgcc caagcaggat ttgactctgt tcaagttgtt gaagcgcaag
     7741 caactgctga cccagacttc tcaactgtaa catctccaaa cccagaaagc caagcagcct
     7801 ttgcccttgc tgaagaactt ggtcgtcaag ttggtgcaga tgttcttgtc gcaactgacc
     7861 cagacgctga ccgtgttggt gttgaagttc ttcaaaaaga tggtagctac ctcaaccttt
     7921 caggtaacca aatcggtgct atcatggcta aatacatctt ggaagctcac aaaaacgctg
     7981 gaactcttcc tgaaaatgcc gctctctgca aatctatcgt ttcaactgac ttggtaacga
     8041 agattgctga aagctacggc gcaactatgt tcaacgtctt gacaggtttc aaatttatcg
     8101 ctgaaaaaat ccaagaattc gaagaaaaac acaaccacac ttacatgatg ggatttgaag
     8161 aaagcttcgg ttacttgatt aaaccatttg tacgtgataa agatgccatc caagccgttc
     8221 ttgtcgttgc tgaacttgct gcctactacc gttctcgtgg tttgacactt gctgacggta
     8281 tcgaagaaat ctataaagaa tatggctact acgcagaaaa aacaatctct gttactcttt
     8341 caggtgtcga tggtgctgaa caaatcaaag cgattatggc taaattccgc aacaatgctc
     8401 caacagaatg gaacgcaaca gctatcactg tcgtagaaga cttcaaggca caaactgcta
     8461 ctgttgctga cggtactgtt acaaacttga caactcctcc aagtgatgtg ttgaaataca
     8521 cacttgctga cggttcatgg attgccgttc gcccttcagg tacagaacca aaaatcaagt
     8581 tctacattgc agttgtaggg gaaaccaacg aagaatcaca agctaagatt gctaacatcg
     8641 aagcagaaat caatgcattt gtaaaataaa gacctataaa agatgagacc aaccaacctc
     8701 atcttttttc gtatcaaatc taagcaattt tagaaacttt atggcatact agacttatca
     8761 atgaaagcga ggtaatctca tggaacaatt tttagataac atcaaagacc ttgaagtcac
     8821 tacagttgtg cgtgcgcaag aagctcttga taaaaaagaa actgcaacct tctttatcgg
     8881 tcgcaaaact tgcccttact gccgtaaatt tgcaggtaca ttgtcaggtg tcgtagctga
     8941 aaccaaagct cacatttact tcatcaatag tgaagaacca agccaactca atgatttgca
     9001 agcattccgc tcacgctatg gaatcccaac tgtaccaggt tttgttcata ttacagatgg
     9061 acaaatcaac gtccgttgcg actcttcaat gtcagcacaa gaaatcaaag atttcgcagg
     9121 attgtaaaaa atcagctaac aagtcttaaa atcacaaaaa cgcataatgt aaggtgcaaa
     9181 aaccttgata ttatgcgttt tattgttcct aaaacagtta catcagtatt tcattacaga
     9241 acattttaat tttggaagtc aaatcaattt ttaacaatgt tttagaaatc acagtgggct
     9301 attccatatt caatcgctat tatcgttttc ctagattaca aaaaaactac gttttgctaa
     9361 tcaaaacgca gtttcagcca ctattttatc ttactatcct tcttttactt ctttggttgc
     9421 tacatcttct ccaaaccatt tttggctgat ttcttggaac ttgccgtcct tgtaaagact
     9481 agaaaaagct tcatttatct tcttaaccaa ggttatatct tccttacggg ctccaaccgc
     9541 aaaagcttct gtttctagtc caactgtaaa gacattataa tcgtttaaaa caccttctgc
     9601 ttctaaataa tagtttgcat agacacggtc aatcaataga ccatcaattc gatcgttttt
     9661 caaatcaatc aaggcttcat taaaggtttg gtattgattc gcttccttat tagcgacaat
     9721 attcttcaaa atttctggat ttgcttcaaa gtccgcataa ctagatgaac cagcttgagc
     9781 tcctaatgtc tttccagtca tatcctttgc agtcgtgata ccagatgatt tcttcgtaac
     9841 caatacctgc tcattcttca tatatgagtt actgaaagca accttttcac ggcgttcgtc
     9901 tgtagcggaa tagccattcc aaatcagatc aatcgttcct tttgtcaatt cagcttcttt
     9961 caaatcccaa tcaatcggtt gccaatttac cgtgattccg tatttttcaa aaacagctgt
    10021 agctaaatca atatcaaatc ctgcataaga accatctttc tgagcaaatc ccattggaac
    10081 aaaagtacta tcaaatccaa tagtaataga cttgttagac tggtactttg accaattatc
    10141 tccactagtt tcgctagaat ttttcccaca agctactaag aacaaagcag tcatcagact
    10201 gactaataca agcatccatt ttttcatcca tttttcctcc tatttaggtt ctactttcaa
    10261 taatacatct gcgatatttt cagcaaactg caaatcatgg gtaaccacaa tctgggtcat
    10321 cccaagttcc ctattttgca agattagctt ctccacttcc aaacgtaatt ctggatccag
    10381 ggcagaagtt ggttcatcgt agccaatgat ttctgggtca atcatcatag cacgcgccaa
    10441 agccacccgc tgcttttgcc caccagatag tgagaaagga taggcctctg cgtgtcctcc
    10501 tagtcctaac tgttccaaga gtccactcgc cttcttctca gcctcttcct gcttcattcc
    10561 catggtcttc acaggcgata aggtcaaatt gtccagaact gataaatgag ggaacagttg
    10621 aaaatcttgg aatacaaatc ccagtagatt gcgcttctgc aattcatcca gctctaaagg
    10681 ttgtccatta taaaagattt gccctgaatc aatggtttca agacctgcaa gcatacgtaa
    10741 aagagttgtc ttacctccac cagaaggtcc aacgatagcc aggatttgct tttcaggaat
    10801 acttagactg aaattagaca ggatttgttt gtctccaaag actttattga tatttcgtaa
    10861 ttctaacatg gcagcctcct atctataata actatacttc ttctcaactt ttttggaaat
    10921 aattgtcaca atcccaatca aaatcaaata aatggctcct gccaagaaca taggaactag
    10981 actagcatcg cggttagcag ctgttcgact agccaagata aggtctgaaa ttccgagagc
    11041 atagaccaaa gaagtatcct tgaccaaact cataacttca ttaaagacac taggaagaac
    11101 gatcttggtc acttggggca agataatata gcgcactctg tcaaaagggc taaacttcaa
    11161 gaccttggcg gcctcatact gtcctcttgg aatagtgtca attcccccac ggaaaatttc
    11221 tgcaaagtaa gctgcatagt tgagaacaaa ggcaataata gctgcaggaa ggcggtctaa
    11281 acgaatccca atacttggga gcacataata gataaaaatc agttgcaaga gtaagggggt
    11341 tcctcgcata acccagatgt aaatattaat cagataatgg aggggcttcc aatggacttg
    11401 caaggcaaag gcaatcaaaa cgcccaaagg aatcgaaaat agcaagacca gtgcaaagac
    11461 ctgtacagtc gtgctcgcac cattcagtaa actcggtaat atctcaaata aataagacat
    11521 actgcacctc ctaaaagtaa ttgttcctat tatagcatga ataaacaaga ttaccaagta
    11581 tttttgtaaa aagattctac catatacaaa taaaaa
//
LOCUS       DAVHSO010000069        11403 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.070, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000069 DAVHSO010000000
VERSION     DAVHSO010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11403)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11403)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11403
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.070"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            712..1704
                     /locus_tag="VVR18_001901"
     CDS             712..1704
                     /locus_tag="VVR18_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6033374.1"
                     /translation="MAMIEVEHLQKNFVKTVKEPGLKGALRSFIHPEKQTFEAVKDLT
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQDNRQDYVKDIGVV
                     FGQRTQLWWDLALQETYTVLKEIYDVPDSLFHKRMDFLNEVLDLKDFIKDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLS
                     DIEQLCDRIFMIDKGQEIFDGTVSQLKETFGKMKTLSFELLPGQSHLVSHYDGLSDMT
                     IDRQGNSLNIEFDSSRYQSADIIKQTLSDFEIRDLKMVDTDIEDIIRRFYRKEL"
     gene            1706..2524
                     /locus_tag="VVR18_001902"
     CDS             1706..2524
                     /locus_tag="VVR18_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HEU6033375.1"
                     /translation="MIKLWRRYKPFINAGVQELITYRVNFILYRIGDVMGAFVAFYLW
                     KAVFDSSQESLIQGFSMADITLYIIMSFVTNLLTRSDSSFMIGEEVKDGSIIMRLLRP
                     VHFAASYLFTELGSKWLIFISVGLPFLSVIVLMKIISGQGIVEVLGLTVIYLFSLTLA
                     YLINFFFNICFGFSAFVFKNLWGSNLLKTSIVAFMSGSLIPLAFFPKVVSDILSFLPF
                     SSLIYTPVMIIVGKYDASQILQALLLQFFWLLVMVGLSQLIWKRVQSFITIQGG"
     gene            2526..3311
                     /locus_tag="VVR18_001903"
     CDS             2526..3311
                     /locus_tag="VVR18_001903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033376.1"
                     /translation="MKKYQRMHLIFIRQYIKQIMEYKVDFVVGVLGVFLAQGLNLLFL
                     NVIFQHIPFLEGWTFQEIAFIYGFSLIPKGMDHLFFDNLWALGQRLVRKGEFDKYLTR
                     PINPLFHILVETFQIDALGELLVGGILLGTTVTSIVWTLPKFLLFLVCIPFATLIYTS
                     LKIATASIAFWTKQSGAMIYIFYMFNDFAKYPISIYNSLLRWLISFIVPFAFTAYYPA
                     SYFLQEKDVFFNVGGLMLISLVFFVISLKLWDKGLDSYESAGS"
     gene            3409..3627
                     /locus_tag="VVR18_001904"
     CDS             3409..3627
                     /locus_tag="VVR18_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family acetyltransferase"
                     /protein_id="HEU6033377.1"
                     /translation="MKDLPEWFGIPESTQAYIEGTTTLQVWTAYQESDLTGFVRLSYS
                     SEDCAEIDCLGVKKLIKVEKLGANCLLL"
     gene            3612..3809
                     /locus_tag="VVR18_001905"
     CDS             3612..3809
                     /locus_tag="VVR18_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033378.1"
                     /translation="MLATLESEARKKVGYLQVKTVAEGSNKDYDRTNDFYRGLGFKKL
                     EIFSQLWNPQNPCQILIKKLE"
     gene            complement(4235..4321)
                     /locus_tag="VVR18_001906"
                     /pseudo
     CDS             complement(4235..4321)
                     /locus_tag="VVR18_001906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            4542..10976
                     /locus_tag="VVR18_001907"
     CDS             4542..10976
                     /locus_tag="VVR18_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HEU6033379.1"
                     /translation="MKKSTVLSLTTAAVILAAYAPNEVVLADTSSSEDALSISDKEKV
                     VVDKETENKEKHKDIHNAIETSKDTEEKKTTIIEEKEVVSKNPVIDNNTSNEEARIKE
                     DSNQSQGDNAHSSANKNTENPKKEDKVVYIAEFKDKESGEKAIKQLSSLKNTKVLYTY
                     DRIFNGSAIETTPDNLDKIKQIEGISSVERAQKVQPMMNHARKEIGVEEAIDYLKSIN
                     APFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDKI
                     PHAFNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNAQ
                     IFSYKMYSDAGSGFAGDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRAL
                     RKAGIPMVVATGNYATSASSSSWDLVANNHLKMTDTGNVTRTAAHEDAIAVASAKNQT
                     VEFDKVNIGGESFKYRNIGAFFDKNKITTNEDGTKAPSKLKFVYIGKGQDQDLIGLDL
                     RGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEGT
                     KSQVFSISGDDGVKLWNMINPNKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNVG
                     DEKEIDFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVIN
                     GKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIALQ
                     NTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATFKNTDSKGLVNSYGS
                     ISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAITTDSLTDRLKLDETYKDEKSPDGK
                     QIVPEIHPEKVKGANITFEHDTFTIGANSSFDLNAVINVGEAKNKNKFVESFIHFESV
                     EEMEALNSNGKKINFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSRSKTLGGYDDDGK
                     PKIPGTLNKGIGGEHGIDKFNPAGVIQNRKDKNTTSLDQNPELFAFNNQGINAPSSSG
                     SKIANIYPLDSNGNPQDAQLERGLTPSPLVLRSAEEGLISIVNTNKEGENQRDLKVIS
                     REHFIRGILNSKSNDAKGIKSSKLKVWGDLKWDGLIYNPRGREENAPESKDNQDPATK
                     IRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDFSNPEKIKLIT
                     KDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEVTYA
                     GEGQGRNRKLDKDGNTIYEIKGAGDLRGKIIEVIALDGSSNFTKIHRIKFANHADEKG
                     MISYYLVDPDKDASKYQKLGEIAESKFKNLGNGKEGSLKKDTTGVEHHHQENEESIKE
                     KSSFTIDRNISTIRDFENKDLKKLIKKKFREVDDFTSETGKRIEEYDYKYDDKGNIIA
                     YDDGSALQYETEKLDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNSYKSIE
                     IKATKYDSHSKTMTFDLYANINDIVDGLAFAGDMRFFVKDDDRIKAETKIRMPEKNKE
                     TKAEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKG
                     YALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRVLSETTIYADSRNVEDGRST
                     QAVLMSALDGFNIIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYTGEDK
                     SNVEAIKEDGSMLFIDTKPVNLSMDKNYFNPSKSNKIYVRNPEFYLRGKISDKGGFNW
                     ELRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGFPDKVTDMD
                     GNVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGKSVVFNINDKR
                     NNGFDGEIQEQHIYVNGKEYTSFDDIKQITDKTLNIKIVVKDFARNTTVKEFILNKDT
                     GEVSELKPHRVTVTIQNGKEMSSTIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKK
                     DAGYVINLSKDTFIKPVFKKIEEKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDL
                     QREDHSQKSDSTKDVTATVLDKNNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIV
                     GIFLGLKKKNQD"
BASE COUNT         3972 a         1712 c         2297 g         3422 t
ORIGIN      
        1 attatggtat cgaatcttca tcagaatgat aaaattaatc aattgatatc tgattacaaa
       61 cagaatatga aagcttttta tatcactatt gaaaaattta tacgaaatga tgaaagtctt
      121 aagtgttatt ttataaaggt tatttcaagt cgttccaagg taacaagtct agatcagatt
      181 gaagctgata aaacgataca aagaaaatat tcaagtgagc taaaaaattt attggatttt
      241 ataatgagat tatttgtgag gaaaatagtt tcctacatgt acgaaagagg tggtcgagtt
      301 ggtttaggta gtcggtgcgt gagttgataa ttctcagggt atggacttct ttttcatgaa
      361 tgaggtaaaa gagcaggtat tgtttagaga caatcattct gagcatattt tctggataga
      421 gggagtatcc gattttatga tcaaagttaa taccgccctc tggtgagaag atgagtaggt
      481 tggtaattta aactattaaa cagaattttt gattaaaagt attatttcat gagagaaatc
      541 ctaatttcac aatccatagg caaactcttg catttcgttt tttattggac tataataggt
      601 tggtataaag ccttttgtag taataaaatg tagaaggtgt agaaagcaag gatttagaat
      661 atttgtagtt aaaaacacaa tgttgctatt ccttacgata gggagataga tatggcaatg
      721 atagaagtgg aacatcttca gaaaaatttt gtgaagactg ttaaggaacc gggcttgaag
      781 ggggctttgc gctcctttat tcatcctgaa aagcagacct ttgaagcggt caaggatttg
      841 acctttgagg ttccaaaagg gcagatttta ggatttatcg gggcaaatgg tgctgggaag
      901 tcgacaacca ttaaaatgct gacaggaatt ttgaaaccaa catctggttt ttgtcggatt
      961 aacggcaaga ttccccagga caatcggcaa gattatgtca aagatattgg cgtagtcttt
     1021 ggacaacgca cccagctatg gtgggatttg gctctgcaag agacctacac tgtcttaaaa
     1081 gagatttatg atgtgccaga ctcgctcttt cataagcgta tggacttttt gaatgaagtc
     1141 ttggatttga aggactttat caaggatccc gtgcggactc tttcactggg acaacggatg
     1201 cgggcggata ttgcggcctc cttgctccac aatcccaagg ttcttttttt agatgagccg
     1261 accattggtt tggacgtttc ggttaaggat aatattcgtc gggcaattac tcagatcaat
     1321 caagaggaag aaactaccat tcttttgacc actcacgatt tgagtgatat tgagcaactt
     1381 tgtgatcgga ttttcatgat tgacaagggg caagagattt ttgatggaac ggtgagccaa
     1441 ctcaaggaga cctttggtaa gatgaagact ctctcttttg aactgctacc aggtcaaagt
     1501 catctcgtct ctcactatga cggtctgtct gatatgacca ttgatagaca aggaaacagc
     1561 ctcaacattg aatttgatag ttctcgctac cagtcagctg acattatcaa gcaaaccctg
     1621 tctgattttg aaatccgcga tttgaagatg gtggatacgg atattgagga tattatccgt
     1681 cgcttctacc gaaaggagct ctaggatgat caaattgtgg agacgttata aaccctttat
     1741 caatgcaggg gttcaggagt tgattactta ccgagtcaac tttattctct atcggattgg
     1801 cgatgtcatg ggggcttttg tggcctttta tctctggaag gctgtctttg attcttcgca
     1861 agagtctttg attcagggct tcagtatggc ggatatcacc ctctacatca tcatgagttt
     1921 tgtgaccaat cttctgacta gatccgattc gtcctttatg attggggagg aggtcaagga
     1981 tggctccatt atcatgcgtt tgttgcgacc agtgcatttt gcggcctcct atcttttcac
     2041 cgagcttggt tccaagtggt tgatttttat cagcgttggc cttccatttt taagtgtcat
     2101 tgtcttgatg aaaatcatat cgggtcaagg tattgtagag gtgctaggat taactgtcat
     2161 ttatcttttt agcttaacgc tcgcctatct gattaacttt ttctttaata tttgctttgg
     2221 attttcagcc tttgtgttta aaaatctttg gggttccaac ctacttaaga cttccatagt
     2281 ggcttttatg tcggggagtt tgattccctt ggcattcttt ccaaaggttg tttcagatat
     2341 tctctccttt ttgccttttt catccttgat ttatactcca gttatgatca ttgttggaaa
     2401 atacgatgcc agtcagattc ttcaggcact ccttttgcag ttcttctggc tcttagtgat
     2461 ggtgggattg tctcagttga tttggaaacg ggtccagtcc tttatcacca ttcaaggagg
     2521 ttagtatgaa aaaatatcaa cgaatgcatc tgatttttat cagacaatac atcaaacaaa
     2581 tcatggaata taaggtggat tttgtggttg gtgtcttggg agtctttctg gctcaaggct
     2641 tgaatctctt gtttctcaat gtcatctttc aacatattcc attcctagaa ggctggacct
     2701 ttcaagagat agctttcatt tatggatttt ccttgattcc caagggaatg gaccatctct
     2761 tttttgacaa tctctgggca ctagggcaac gcctagtccg aaaaggggag tttgacaagt
     2821 atctgactcg tcccatcaat cctctctttc atatcctagt tgaaaccttt cagattgatg
     2881 ccttgggtga actcttagtc ggtggtattt tattgggaac aacagtgacc agcattgttt
     2941 ggactcttcc aaaattcctg cttttcctag tttgtattcc ttttgcgacc ttgatttata
     3001 cttctcttaa aatcgcaaca gccagtatcg ccttttggac taagcagtca ggcgccatga
     3061 tttacatctt ctatatgttc aatgactttg ctaagtatcc gatttctatt tacaattctc
     3121 ttcttcgttg gttgattagc tttatcgtgc ctttcgcctt tacagcctac tatccagcta
     3181 gctatttctt acaggaaaag gatgtgttct ttaacgtagg aggtttgatg ttgatttctc
     3241 tggttttctt tgttatttcc cttaaacttt gggataaggg cttagattcc tacgaaagtg
     3301 cgggttcgta aaagctaaag taagactaaa atcaagaaag gaacttatga tgtttgtaat
     3361 tgaagaagtc aaggatgaaa atcaaaaaag gcagttgtcg ctgaggtttt gaaggatttg
     3421 ccagaatggt ttggaatccc agaaagcaca caagcctata tagaaggaac cacgacactg
     3481 caagtttgga ccgcctatca ggagagtgat ttgactggat ttgtaaggtt atcctattcg
     3541 agtgaagatt gtgcagagat tgattgtctc ggcgtaaaaa agcttatcaa ggtagaaaaa
     3601 ttgggagcca attgcttgct actttagaga gtgaagctcg taaaaaagtt ggttatctgc
     3661 aggtcaaaac agtggcagaa ggttctaata aagattatga tcgaacaaat gacttttatc
     3721 gaggtcttgg ctttaaaaag ttagagattt tttctcagct atggaatccg caaaatcctt
     3781 gtcagatttt gattaaaaag cttgaataat attacttgac atctattctc agagtgctat
     3841 actgtaagtg taatcgccga tttagctcag ttggtagagc aaggcactcg taaagcctag
     3901 gttataggta gataaacgac tgaggagttg aaaaaataga taggtagaag ataaccgtta
     3961 agccttattc ttagcggtta tttatattgt ttaatagcgc tgatatttca tcaattatgc
     4021 ctgttttcgt gtttctggta gttgttcaag tttattgcta ctatttttga tggtatgaat
     4081 gtgcttataa tgtatcccgg ttaacgaaag ttttggactt atactcttcg aaaatctctt
     4141 caaaccacgt cagcgtcgcc ttgccgtata tatggttact gacttcgtca gttctatcta
     4201 caacctcaaa accatgtttt gagctgactt cgtcagtttc atctacaacc tcaaaacagt
     4261 gttttgagca acctgcggct agtttcctag tttgctcttt gattttcatt gagtactaat
     4321 cttatttttt aacgtgtgct aaaaaataaa ttaatgcagg ttaatttttc ttgaattaaa
     4381 tttttttaaa tgatatactg tttttatgga gagataacaa ttatatataa atgtactact
     4441 ctatttccta gataatactt agtaaaactt tttataacaa aggctagcaa agttaaagtt
     4501 tattatctat tggaagttat ataaatatgt aaggaattaa aatgaaaaaa agtacagtat
     4561 tgtcattaac cacagctgca gttattttag cagcctatgc ccctaatgag gtagtcttag
     4621 cagacacatc tagctctgaa gatgctttaa gcatctctga taaagaaaaa gtagtagtag
     4681 ataaggaaac agaaaataaa gagaaacata aagatattca taatgctata gaaacttcaa
     4741 aggatactga agaaaagaaa acaacaatta ttgaggaaaa agaagttgtt agtaaaaatc
     4801 ctgtgataga caataacact agcaatgaag aagcaagaat caaagaagat tccaatcaat
     4861 ctcaaggaga taatgcacac tcgtctgcaa ataaaaacac agaaaatccc aaaaaagaag
     4921 ataaagttgt ctatattgct gaatttaaag ataaagaatc tggagaaaaa gcaatcaagc
     4981 aactatccag tcttaagaat acaaaagttt tatatactta tgatagaatt tttaacggta
     5041 gtgccataga aacaactcca gataacttgg acaaaattaa acaaatagaa ggtatttcat
     5101 cggttgaaag ggcacaaaaa gtccaaccca tgatgaatca tgccagaaag gaaattggag
     5161 ttgaggaagc tattgattac ctaaagtcta tcaatgctcc gtttgggaaa aattttgatg
     5221 gtagaggtat ggtcatttca aatatcgata ctggaacaga ttatagacat aaggctatga
     5281 gaatcgatga tgatgccaaa gcctcaatga gatttaaaaa agaagactta aaaggaactg
     5341 ataaaaatta ttggttgagt gataaaatcc ctcatgcgtt caattattat aatggtggca
     5401 aaatcactgt agaaaaatat gatgatggaa gggattattt tgacccacat gggatgcata
     5461 ttgcagggat tcttgctgga aatgatactg aacaagatat caaaaacttt aacggcatag
     5521 atggaattgc acctaatgca caaattttct cttacaaaat gtattctgac gcaggatctg
     5581 ggtttgcggg tgatgaaaca atgtttcatg ctattgaaga ttctatcaaa cacaacgttg
     5641 atgttgtttc ggtatcatct ggttttacag gaacaggtct tgtaggtgag aaatattggc
     5701 aagctattag ggcattaaga aaagcaggca ttccaatggt tgtcgctacg ggtaactatg
     5761 cgacttctgc ttcaagttct tcatgggatt tagtagccaa taatcatctg aaaatgaccg
     5821 acactggaaa tgtaacacga actgcagcac atgaggatgc gatagcggtc gcttctgcta
     5881 aaaatcaaac agttgagttt gataaagtta acataggtgg agaaagtttt aaatacagaa
     5941 atataggggc ctttttcgat aagaataaaa tcacaacaaa tgaagatgga acaaaagctc
     6001 ctagtaaatt aaaatttgta tatataggca aggggcaaga ccaagatttg ataggtttgg
     6061 atcttagggg caaaattgca gtaatggata gaatttatac aaaggattta aaaaatgctt
     6121 ttaaaaaagc tatggataag ggtgcacgcg ccattatggt tgtaaatact gtaaattact
     6181 acaatagaga taattggaca gagcttccag ctatgggata tgaagcggat gaaggtacta
     6241 aaagtcaagt gttttcaatt tcaggagatg atggtgtaaa gctatggaac atgattaatc
     6301 ctaataaaaa aactgaagtc aaaagaaata ataaagaaga ttttaaagat aaattggagc
     6361 aatactatcc aattgatatg gaaagtttta attccaacaa accgaatgta ggtgacgaaa
     6421 aagagattga ctttaagttt gcacctgaca cagacaaaga actctataaa gaagatatca
     6481 tcgttccagc aggatctaca tcttgggggc caagaataga tttactttta aaacccgatg
     6541 tttcagcacc tggtaaaaat attaaatcca cgcttaatgt tattaatggc aaatcaactt
     6601 atggctatat gtcaggaact agtatggcga ctccaatcgt ggcagcttct actgttttga
     6661 ttagaccgaa attaaaggaa atgcttgaaa gacctgtatt gaaaaatctt aagggagatg
     6721 acaaaataga tcttacaagt cttacaaaaa ttgccctaca aaatactgcg cgacctatga
     6781 tggatgcaac ttcttggaaa gaaaaaagtc aatactttgc atcacctaga caacagggag
     6841 caggcctaat taatgtggcc aatgctttga gaaatgaagt tgtagcaact ttcaaaaaca
     6901 ctgattctaa aggtttggta aactcatatg gttccatttc tcttaaagaa ataaaaggtg
     6961 ataaaaaata ctttacaatc aagcttcaca atacatcaaa cagacctttg acttttaaag
     7021 tttcagcatc agcgataact acagattctc taactgacag attaaaactt gatgaaacat
     7081 ataaagatga aaaatctcca gatggtaagc aaattgttcc agaaattcac ccagaaaaag
     7141 tcaaaggagc aaatatcaca tttgagcatg atactttcac tataggcgca aattctagct
     7201 ttgatttgaa tgcggttata aatgttggag aggccaaaaa caaaaataaa tttgtagaat
     7261 catttattca ttttgagtca gtggaagaaa tggaagctct aaactccaac gggaagaaaa
     7321 taaacttcca accttctttg tcgatgcctc taatgggatt tgctgggaat tggaaccacg
     7381 aaccaatcct tgataaatgg gcttgggaag aagggtcaag atcaaaaaca ctgggaggtt
     7441 atgatgatga tggtaaaccg aaaattccag gaaccttaaa taagggaatt ggtggagaac
     7501 atggtataga taaatttaat ccagcaggag ttatacaaaa tagaaaagat aaaaatacaa
     7561 catccctgga tcaaaatcca gaattatttg ctttcaataa ccaagggatc aacgctccat
     7621 catcaagtgg ttctaagatt gctaacattt atcctttaga ttcaaatgga aatcctcaag
     7681 atgctcaact tgaaagagga ttaacacctt ctccacttgt attaagaagt gcagaagaag
     7741 gattgatttc aatagtaaat acaaataaag agggagaaaa tcaaagagac ttaaaagtca
     7801 tttcgagaga acactttatt agaggaattt taaattctaa aagcaatgat gcaaagggaa
     7861 tcaaatcatc taaactaaaa gtttggggtg acttgaagtg ggatggactc atctataatc
     7921 ctagaggtag agaagaaaat gcaccagaaa gtaaggataa tcaagatcct gctactaaga
     7981 taagaggtca atttgaaccg attgcagaag gtcaatattt ctataaattt aaatatagat
     8041 taactaaaga ttacccatgg caggtttcct atattcctgt aaaaattgat aacaccgccc
     8101 ctaagattgt ttcggttgat ttttcaaatc ctgaaaaaat taagttgatt acaaaggata
     8161 cttatcataa ggtaaaagat cagtataaga atgaaacgct attcgcgaga gatcaaaaag
     8221 aacatcctga aaaatttgac gagattgcga acgaagtttg gtatgctggc gccgctcttg
     8281 ttaatgaaga tggagaggtt gaaaaaaatc ttgaagtaac ttacgcaggt gagggtcaag
     8341 gaagaaatag aaaacttgat aaagacggaa ataccattta tgaaattaaa ggtgcgggag
     8401 atttaagggg aaaaatcatt gaagtcattg cattagatgg ttctagcaat ttcacaaaga
     8461 ttcatagaat taaatttgct aatcatgctg atgaaaaggg gatgatttcc tattatctag
     8521 tagatcctga caaagatgct tctaaatatc aaaagcttgg cgagattgca gaatctaaat
     8581 ttaaaaattt aggaaatgga aaagagggta gtctaaaaaa agatacaact ggggtagaac
     8641 atcatcatca agaaaatgaa gagtctatta aagaaaaatc tagttttact attgatagaa
     8701 atatttcaac aattagagac tttgaaaata aagacttaaa gaaactcatt aaaaagaaat
     8761 ttagagaagt tgatgatttt acaagtgaaa ctggtaagag aatagaggaa tacgattata
     8821 aatacgatga taagggaaat attattgctt atgacgatgg tagtgcctta caatatgaaa
     8881 ctgaaaaact tgacgaaata aaatcaaaaa tttatggcgt tctaagccca tctaaagatg
     8941 gacactttga aattcttgga aagataagca atgtttctaa aaatgccaag gtatattatg
     9001 gaaatagcta taaatcgata gaaatcaaag cgactaagta tgactcacat tcaaaaacga
     9061 tgacatttga tttatacgct aatattaatg atattgtgga tggattagct tttgctggag
     9121 atatgcggtt ttttgttaaa gatgatgatc gaataaaagc tgaaactaaa attagaatgc
     9181 ctgaaaaaaa taaggaaact aaagcagaat atccgtatgt atcaagttat gggaatgtaa
     9241 tcgaattagg agaaggagat ctttcaaaga acaaaccaga caatttaact aaaatggaat
     9301 ctggtaaaat ctattctgat tcagaaaaac aacaatatct gttaaaggat aacatcattc
     9361 taagaaaagg ctatgcacta aaagtgacta cctataatcc tggaaaaacg gatatgttag
     9421 aaggaaatgg agtctatagc aaggaagata tagcaaaaat acaaaaggcc aatcctaatc
     9481 taagagtcct ttcagaaaca acaatttatg ctgatagtag aaatgttgaa gatggaagaa
     9541 gtacccaagc tgtattaatg tcggctttgg acggctttaa cattataagg tatcaagtgt
     9601 ttacatttaa aatgaacgat aaaggggaag ctatcgataa agacggaaat cttgtgacag
     9661 attcttctaa acttgtatta tttggtaagg atgataaaga atacactgga gaggataagt
     9721 ccaatgtaga agctataaaa gaagatggct ccatgttatt tattgatacc aaaccagtaa
     9781 acctttcaat ggataagaac tactttaatc catctaaatc taataaaatt tatgtacgaa
     9841 atccagaatt ttatttaaga ggtaagattt ctgataaggg tggttttaac tgggaattga
     9901 gagttaatga atcggttgta gataattatt taatctacgg agatttacac attgataaca
     9961 ctagagattt taatattaag ctgaatgtta aagacggtga catcatggac tggggaatga
    10021 aagactataa agcaaacgga tttccagata aggtaacaga tatggatgga aatgtttatc
    10081 ttcaaactgg ctatagcgat ttgaatgcta aagcagttgg agtccactat cagtttttat
    10141 atgataatgt taaacccgaa gtaaacattg atcctaaggg aaatactagt atcgaatatg
    10201 ctgatggaaa atctgtagtc tttaacatca atgataaaag aaataatgga ttcgatggtg
    10261 agattcaaga acaacatatt tatgtaaatg gaaaagaata tacatcattt gatgatatta
    10321 aacaaataac agacaagaca ctaaacatta agattgttgt aaaagatttt gcaagaaata
    10381 caaccgtaaa agaattcatt ttaaataaag atacgggaga ggtaagtgaa ttaaaacctc
    10441 atagggtaac tgtgaccatt caaaatggaa aagaaatgag ttcaacgata gtgtcggaag
    10501 aagattttat tttacctgtt tataagggtg aattagaaaa aggataccaa tttgatggtt
    10561 gggaaatttc tggtttcgaa ggtaaaaaag acgctggcta tgttattaat ctatcaaaag
    10621 atacctttat aaaacctgta ttcaagaaaa tagaggagaa aaaggaggaa gaaaataaac
    10681 ctacttttga tgtatcgaaa aagaaagata acccacaagt aaaccatagt caattaaatg
    10741 aaagtcacag aaaagaggat ttacaaagag aagatcattc acaaaaatct gattcaacta
    10801 aggatgttac agctacagtt cttgataaaa acaatatcag tagtaaatca actactaaca
    10861 atcctaataa gttgccaaaa actggaacag caagcggagc ccagacacta ttagctgccg
    10921 gaataatgtt tatagtagga atttttcttg gattgaagaa aaaaaatcaa gattaagaca
    10981 aaagctatag aaaaaaatgg tttatgtact gagattagat agtgaggtga tgacatagtt
    11041 ttgtgaaaac agccatttat aactcaatta tttagtttac ttcactattg atactatttg
    11101 gagttattaa tggacttagt ttagataact aatgaattga ttgcaagggt tagtattgac
    11161 aatattggtc atattgatta gaaaatagag tctatcaaaa tttaaaggct aatagaggtg
    11221 atgagacaat ttcaaggaat taagtagcgt ttggttgctt aattcctttt tatttggaag
    11281 gaagtttttc gtaaccgccc aataacgaag tctattggac ggttacgata tgatcactga
    11341 cttcgtcagt cttatctaca acctcaaaac tgtgttttga gcaacctgcg gctagcttcc
    11401 tag
//
LOCUS       DAVHSO010000070        11048 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.071, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000070 DAVHSO010000000
VERSION     DAVHSO010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11048)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11048)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11048
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.071"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..574
                     /locus_tag="VVR18_001908"
                     /pseudo
     CDS             1..574
                     /locus_tag="VVR18_001908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611513.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(690..1493)
                     /locus_tag="VVR18_001909"
     CDS             complement(690..1493)
                     /locus_tag="VVR18_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic/DOC family protein"
                     /protein_id="HEU6033380.1"
                     /translation="MQSTYNIDNPNLSYEAKRDLWRIGFGLQKVDNLVPSAYMESLAE
                     KQSRGELTYEQVYEDATAYHHTIDASTEEADLVSLRIVELLSRRGFSFSPATLLAIHK
                     ELFQDIFEPSIPVGQFRQTNITKNEPVLNGESVVYSDYSMIQMTLDYDFNQEKQVAYA
                     TLTQADVVKQIQHFISGIWQIHPFREGNTRTVTVFLIQYLREFGFDIDNTPFQQHSKY
                     FRDALVLDNAKILQRRSEFLTAFFENLLLGGQNDLSSEKMYLDLDLDFS"
     gene            complement(1770..2525)
                     /locus_tag="VVR18_001910"
     CDS             complement(1770..2525)
                     /locus_tag="VVR18_001910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3883 domain-containing protein"
                     /protein_id="HEU6033381.1"
                     /translation="MSKHPHYELLNLIGYGLAKFDKLFIKEFQCSSKSEFYRYVVSLG
                     IAETTGVVKNRMDLFDPYFDNNRKGWWQKAEVYRFRKDLIDMMFGNEDVHSYAEIVKM
                     LLASEGKKTGITIVEKPIVRTKFKRLQETGMEAENYFILHFDKEEKFQGGQLTDARLY
                     GDGYDFQVDVQEYSYLAEVKGIRKSKGRVRLTAKEFEKVKEFQSDFILSLVTNLDDIP
                     KLVLIDNPLKHFEFKKNIIKNEIIEYRSVEDLY"
     gene            complement(2595..5246)
                     /locus_tag="VVR18_001911"
     CDS             complement(2595..5246)
                     /locus_tag="VVR18_001911"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HEU6033382.1"
                     /translation="MSKELSSKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIP
                     PPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEG
                     ISRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVF
                     VDLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVAT
                     TRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPEFGTGVVKIT
                     PAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVVAKLEEIGALV
                     KIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDT
                     FLQWMENVHDWVISRQLWWGHQIPAWYNADGEMYVGEEAPEGDGWTQGEDVLDTWFSS
                     ALWPFSTMGWPEVDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVL
                     IHGLIRDEEGCKMSKSLGNGIDPMDVIDKYGTDSLRWFLSNGSAPGQDVRFSYEKMDA
                     SWNFINKIWNISRYILMNNEGLTLDVAHDNVTKVATGEAGNVTDRWILHNLNETIAKV
                     TENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEEEKVITRSVLLYTLDKI
                     LRLLHPIMPFVTEEIFGQISEGSIVTAEYPTVNPAFEDLAAHTGVESLKDLIRAVRNA
                     RAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSS
                     VITGAEIFLPLVDLLNVEEELARLEKELAKWQKELDMVGKKLSNERFVANAKPEVVQK
                     ERDKQADYQAKYDATVARIDEMKKLVK"
     gene            complement(5239..5817)
                     /locus_tag="VVR18_001912"
     CDS             complement(5239..5817)
                     /locus_tag="VVR18_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000550018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEU6033383.1"
                     /translation="MHLFIIGAPASGKMTIGQELSRLTDATLFYNHQAIDFALEIYQD
                     YTEEMWEFVRGITFSFLGASARNQRSVILTDVIDFSNQYHLIYLKQIQNLLDDYHQEI
                     LFVELETSLEECIRRNRTENRLKHKPLKRHIEVSEREILETAETLQLNSQYQPNELHH
                     YFKINNTNLSAEEAAKQIQNKINKIEKGHTHV"
     gene            complement(5817..6377)
                     /locus_tag="VVR18_001913"
     CDS             complement(5817..6377)
                     /locus_tag="VVR18_001913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000124561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033384.1"
                     /translation="MARTELPDKIETERLVLRVRTVADAEDIFDYASLPEVAYPAGFP
                     PVKTLEDEIYYLEHILPERNQKENLPAGYGIVVKGTDKIVGSIYFNHRHEDDVMEIGY
                     TLHSDYWGRGYVPEAARALIDLAFKDLGLHKIELTCFGYNLQSQRVAEKLGFTLEARI
                     RDRKDAQGNCCDDLRYALLKSEWGVI"
     gene            complement(6364..6813)
                     /locus_tag="VVR18_001914"
     CDS             complement(6364..6813)
                     /locus_tag="VVR18_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase"
                     /protein_id="HEU6033385.1"
                     /translation="MIGVVARENAAEQIKQYQKFTVNISDETSMLAMEQAGFISHQEK
                     LERLGVHYEISERTQTPILDACPLVLDCRVDRIVEEDGICHIFAKILERLVAPELLDE
                     KGHFKNQLFAPTYFMGDGYQRVYRYLDKRVDMKGSFIKKARKKDGKN"
     gene            complement(7226..7621)
                     /locus_tag="VVR18_001915"
     CDS             complement(7226..7621)
                     /locus_tag="VVR18_001915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HEU6033386.1"
                     /translation="MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQSAS
                     AAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFK
                     NWTEKELLDLKGIGPATIKKLKENGIKFK"
     gene            complement(7717..7971)
                     /locus_tag="VVR18_001916"
     CDS             complement(7717..7971)
                     /locus_tag="VVR18_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1912 family protein"
                     /protein_id="HEU6033387.1"
                     /translation="MSYEQEFMKEFEAWVNTQIMINDMAHKESQKVYEEDQDERAKDA
                     MIRYESRLDAYQFLLGKFENFKVGKGFHDLPEGLFGERNY"
     gene            complement(7981..9315)
                     /locus_tag="VVR18_001917"
     CDS             complement(7981..9315)
                     /locus_tag="VVR18_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000752887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF438 domain-containing protein"
                     /protein_id="HEU6033388.1"
                     /translation="MVDERIHVLRDILLELHNGASPESVQERFDATFAGVSAIEISLM
                     EHELMNSESGVTFEDVMELCDVHANLFKNAIKGVEVSDTEHPGHPVRVFKEENLALRA
                     ALIRIRRLLDTYESMEDEEMLAEMRKGLVRQMGLVGQFDIHYQRKEELFFPIMERYGH
                     DSPPKVMWGVDDQIRELFQTALTTAKSLPEVSISSVKEAFEAFATEFESMIFKEESIL
                     LMILLESFTQDDWLQIAEESDAYGYAIIRPSEKWVPERQSFIEEKIAEEPVQLDTAEG
                     QVQQVIDTPEGHFTITFTPKEKEAVLDRHSQQAFGNGYLSVEQANLILNHLPMEITFV
                     NKEDIFQYYNDNTPADEMIFKRTPSQVGRNVELCHPPKYLDKVKTIMKGLREGSKDKY
                     EMWFKSESRGKFVHITYAAVHDEDGEFQGVLEYVQDIQPYREIDTDYFRGLE"
     gene            complement(9315..9548)
                     /locus_tag="VVR18_001918"
     CDS             complement(9315..9548)
                     /locus_tag="VVR18_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1858 domain-containing protein"
                     /protein_id="HEU6033389.1"
                     /translation="MDNIIDVSIPVAEVVDKHPEVLEILVELGFKPLANPLMRNTVGR
                     KVSLKQGSKLAGTPMDKIVRTLEANGYEVIGLD"
     gene            complement(9816..9956)
                     /locus_tag="VVR18_001919"
     CDS             complement(9816..9956)
                     /locus_tag="VVR18_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033390.1"
                     /translation="MKFFWTILAILFIKPIIGIVKFFWMIISFAVQLLFYKILDWFFK
                     LI"
     gene            complement(9953..10135)
                     /locus_tag="VVR18_001920"
     CDS             complement(9953..10135)
                     /locus_tag="VVR18_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033391.1"
                     /translation="MNPIKAFAKIYGNYFLTVQGVKVMKTIKKDDHVVVGLGKLFIAD
                     KLMDTARWLIKPEERE"
     gene            complement(10137..10920)
                     /locus_tag="VVR18_001921"
                     /pseudo
     CDS             complement(10137..10920)
                     /locus_tag="VVR18_001921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840413.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT         3242 a         2446 c         2050 g         3310 t
ORIGIN      
        1 taaaatgcga cagaaacgaa aataaaggag acgttggtaa gaaggcagag aatctcattc
       61 aaggccaatt tgaaggatct aaaacaatgg aaaagtgcta cacagatgtg acagaatttg
      121 ccattccagc aagtactcaa aagctttact tatcaccagt tttagatggc tttaacagcg
      181 aaattatcgc ctataatctt tcaacttcac ccaacttaga acaagtacaa acaatgttgg
      241 aacaggcatt cacagagaag cactacgaga atacgattct ccatagtgac caaggctggc
      301 aataccgaca cgattcttat catcggttcc taagagtaag ggaattcaag catctatgtc
      361 acgcaaggga aacagccaag acaacggtat gatggagtcc ttctttggga ttctgaaatc
      421 ggaaatgttt tacggttatg agaagtcgtt tcagtcgctt aagcaattgg aacaagctat
      481 tgtagactat attgattact acaacaataa acgaattaag gtaaaactaa aaggacttag
      541 ccttgtgcaa tacagaacta aatccttcgg ataaattatt tgtctaactt tttggggtca
      601 gtacacctaa aactttgatg atatacgttt tcttgtgaga atatttactt catttttgcc
      661 taaaattcaa tgtttactca gtatttggat tatgaaaaat cgaggtctaa atctagatac
      721 attttttctg aagacaaatc attttgacca ccgagcaaga gattttcaaa aaaagctgtt
      781 aaaaactcag aacgtcgctg taaaatcttt gcattatcta ataccaaggc atcacgaaaa
      841 tatttggaat gttgctgaaa tggtgtatta tcaatatcaa aaccaaactc acgaagatac
      901 tgaatcaaaa agaccgttac tgtccgagtg tttccttcgc gaaatggatg aatctgccag
      961 attcctgaaa taaaatgctg gatttgttta accacatccg cctgagttag tgtcgcatat
     1021 gcaacttgtt tttcctgatt aaaatcataa tctaaggtca tttgaatcat ggagtaatca
     1081 gagtacacaa cactttcacc attcaaaaca ggttcattct ttgtgatatt ggtctgacga
     1141 aattgcccca ccggaataga gggttcaaat atatcttgaa acaactcctt atgaatagca
     1201 agtaaggtcg caggactaaa gctaaagcct cttcgagaca atagttctac aatacgtaga
     1261 gaaaccaagt ctgcctcttc cgtacttgca tcaatagtat ggtgataagc cgttgcatcc
     1321 tcataaacct gctcataagt cagttctccc cgggactgtt tctcagccaa agattccata
     1381 tacgctgatg gcactagatt gtcaactttc tgcagaccaa aacctatccg ccataaatca
     1441 cgcttcgctt cataagacaa gtttggattg tcaatgttgt aagttgattg catagaaata
     1501 tcctttcaat tgtttttctt cattaccagt aaatcacgaa attggttgga aactggctta
     1561 aactataaaa agtcctcaca ataggttcta tgatatatat atatacttca tgtaaataat
     1621 aaaagagtta taatcagcac tactgataaa ttcaataccg atttcgccat cttaaaactt
     1681 agtcaaacga ataccgttga tttccagttc attaagtcgt tgacctgtca agacttctcg
     1741 ttccttcaac tggaaaagtt aagggggaac taatacaaat cctctacgct tctatattca
     1801 atgatttcat ttttgataat attcttttta aactcaaaat gttttaaagg attatcgatt
     1861 aacactaact ttggaatatc atctagattt gtgaccaagg ataaaataaa atccgattga
     1921 aactccttga ctttttcaaa ttcttttgca gttaaacgca cacgcccctt agattttcgg
     1981 atacctttta cttcggcaag gtaagaatac tcttggacat ctacctgaaa gtcatatcca
     2041 tcaccataaa gacgggcatc ggttaactgt ccaccttgga atttttcttc tttatcaaaa
     2101 tgaaggataa aataattctc agcctccatt cccgtttcct gtagacgttt gaatttagtt
     2161 cgaactattg gtttttcaac gatggttatg cctgttttct tcccttcact ggcaagtaac
     2221 attttaacta tttcagcata actatgaaca tcttcatttc caaacatcat atcaattaaa
     2281 tctttacgaa aacgataaac ttcagctttc tgccaccaac cttttcgatt attgtcaaaa
     2341 taaggatcaa ataaatccat tctatttttt acaactccag ttgtttcagc aattcccaga
     2401 gaaaccacat agcgataaaa ctccgacttg ctagagcatt gaaattcttt tataaaaagc
     2461 ttgtcaaact tggcaagacc gtaaccaatt aaatttaaca attcataatg agggtgtttg
     2521 gacatcactt tctccatcaa tagatattga tttcattata ccaaaaaaca cggctcatca
     2581 ccgtgtttct gtgtttattt caccaacttc ttcatctcat caatacgtgc tacggtcgca
     2641 tcatacttag cttggtaatc tgcttgcttg tcgcgttctt tttggacaac ttctggttta
     2701 gcgttggcga cgaagcgttc gttgctgagt tttttgccaa ccatgtcgag ttctttctgc
     2761 catttggcaa gttctttttc cagacgtgcc aattcttctt cgacattcaa gaggtctacc
     2821 agtggcaaga agatttcggc tcctgtgatg acgcttgaca tagccagttc aggtgcaggg
     2881 atggttgatg cgatttccaa gtgttcagga tttgtgaaac gtttgatgta gttgacattg
     2941 ctgttaaaga aggcttccaa gtcgctatcg cttgtcttaa caaggatagt gataggcttg
     3001 cttggagcaa cgtttacttc cgcacgcgca ttacgaacgg cacggatcaa gtctttaagg
     3061 ctttccacac cagtgtgagc agcaaggtct tcaaaggctg ggttgacagt tgggtattct
     3121 gctgtaacga tagatccttc tgagatttgt ccaaagattt cctctgtcac aaatggcatg
     3181 attgggtgaa ggagacgaag gatcttgtcc aaagtgtata gtagaacaga acgtgtgatg
     3241 actttctctt cttcgttatc gctataaagg acttccttgg tcaactcaac ataccagttg
     3301 gcaaattctt cccagatgaa gttgtaaagg atatgaccag ccacaccaaa ctcgaactta
     3361 tcaaagtttt cagtaacttt tgcaatggtt tcgttgagat tgtggagaat ccagcggtcc
     3421 gtcacattac cagcctcacc tgttgcaact tttgtgacat tgtcatgcgc cacatccagc
     3481 gtcaaacctt cattgttcat gaggatatag cgagaaatgt tccaaatttt gttaataaag
     3541 ttccatgaag catccatttt ctcgtaagag aaacgaacgt cttgaccagg agctgagccg
     3601 tttgacaaga accaacgaag actatctgta ccatatttat caataacatc cattgggtca
     3661 atgccatttc caagagattt agacatctta catccttctt catcacgaat tagaccatgg
     3721 ataaggacgt tttggaatgg ttgacggcct gtgaattcca atgactggaa gatcatacga
     3781 gacacccaga agaagatgat gtcgtaacct gttaccaagg ttgaagttgg gaaataacgt
     3841 ttaaagtctt ctgagtcgac ttcaggccag cccatggttg aaaatggcca gagggcagaa
     3901 ctgaaccaag tatccaagac gtcttcgcct tgagtccatc cgtcaccttc tggagcttct
     3961 tcgccgacat acatttcacc atcagcattg taccaggcag ggatttggtg accccaccaa
     4021 agctgacgag agataaccca gtcgtggaca ttttccatcc attgaaggaa ggtatcgttg
     4081 aaacgaggtg ggtagaattc gaccttgtcc tctgtgtctt ggttggcaat ggcgttctta
     4141 gccaattggt ccatcttgac gaaccattga gtagacaagc gtggctcaac tacgacacct
     4201 gtccgttctg agtgaccgac tgaatggaca cgtttttcga ttttgacaag ggcaccgatt
     4261 tcttccaact tagcaacgac tgccttacga gcttcaaaac gatccatgcc tgaaaattca
     4321 aaggcaagct cattcatagt tccgtcgtcg ttcatgacgt tgacttgtgg caagttatga
     4381 cgttggccaa ccaagaagtc atttggatcg tgggcaggtg tgattttcac gacaccagta
     4441 ccaaactcag gatctgcgtg ctcatctcca acgattggga tgagtttatt agcgattgga
     4501 aggatgacgt ttttaccaat caagtccttg tagcgcgggt cttctggatt aaccgcaacc
     4561 gcaacgtccc caaacatagt ctcaggacga gttgtagcaa cttcaagggc gcgtgaacca
     4621 tcttccagca tgtagttcat gtggtagaag gcaccttcga catccttgtg aatcacctca
     4681 atatcagaaa gggctgtgcg agctgctggg tcccagttga tgataaactc accacggtag
     4741 atccagcctt tcttgtaaag gtccacaaag accttacgaa cagcttttga caaaccttcg
     4801 tcaagagtga aacgctcacg agagtagtct acagagagcc ccatcttgcc ccattgttcc
     4861 ttgatagtag tggcatattc gtctttccat tcccagactt tcgtcaagaa agactcacga
     4921 ccaaggtcat agcgggaaat gccctcacca cgcaagcgct cctctacctt agcctgagtg
     4981 gcaatccctg cgtggtccat cccaggaagc caaagggtat caaaaccttg catgcgtttt
     5041 tgacggatga taatatcttg caaagttgta tcccaagcgt gaccaaggtg aagtttacct
     5101 gtaacgtttg gtggtggaat aacgattgaa taaggcttag ccttttgatc gcctgaaggc
     5161 ttgaaaacat cagcatcaag ccatttttgg taacgaccag cctcaacctc ggctggattg
     5221 tatttagatg aaagttcttt agacatgtgt gtgtcctttc tctattttgt ttattttatt
     5281 ttgaatttgc ttagcagctt cttctgcaga caaattcgta ttatttattt taaagtagtg
     5341 gtgcaactca ttcggttgat attgggaatt taattgaagt gtttcagcgg tctctaaaat
     5401 ttctctttca gatacctcaa tatgtcgttt taagggtttg tgctttaatc gattctccgt
     5461 tcgatttcga cgtatgcact cttcaagact tgtttccaac tcaacaaaaa gaatctcttg
     5521 atgataatca tccaacaaat tctgaatttg ctttaaatat atcagatgat actgatttga
     5581 aaaatcaatt acatctgtta aaattactga tcgctgattt cttgcacttg ctccaaggaa
     5641 tgaaaaagtg attccacgaa caaattccca catttcctct gtatagtcct gatagatttc
     5701 tagtgcaaaa tcaatggctt gatggttata aaatagggta gcatccgtca gtcgagataa
     5761 ttcttgacca atggtcattt ttcctgatgc tggagcacca atgatgaaaa gatgcatcaa
     5821 atcacccccc actcactctt cagcaaggca tatctcaaat catcacagca gttgccttga
     5881 gcatctttac ggtctcttat gcgagcttcg agggtaaagc caagcttttc cgcgactcgt
     5941 tgactttgaa ggttatatcc aaagcaagtt agttcaatct tgtgaagacc caaatcttta
     6001 aaggctaagt caatcaaggc acgcgcagct tctggcacat aacctcgccc ccaatagtct
     6061 gagtgtaagg tatagccgat ttccatcaca tcatcttcat ggcgatggtt gaaatagata
     6121 gagccaacga tcttatccgt tcctttgacg acaatcccgt agcctgctgg gagattttcc
     6181 ttttgattac gctccggaag aatgtgctcc agataataaa tctcatcttc caaggtcttg
     6241 actggaggaa aacctgctgg ataggcgacc tctggcaaac tagcatagtc aaagatatcc
     6301 tcagcatccg ccacagtacg gactcgtaaa acgagacgtt ctgtttcgat tttatctggc
     6361 agctcagttc ttgccatcct tcttcctcgc ttttttgatg aaactgccct tcatatctac
     6421 acgcttgtcc agatagcgat aaacgcgctg atatccatct cccatgaaat atgttggggc
     6481 aaacagttga tttttaaaat gtcccttttc atccaggagt tctggggcaa caagtcgctc
     6541 aagaatcttg gcaaagatgt ggcaaatacc gtcttcctca acaatcctat ctacccgaca
     6601 atctaaaaca agtggacagg cgtctaaaat aggagtctga gttcgttcag aaatttcata
     6661 atgcactccc aaacgttcca atttctcctg atgactgata aaaccagcct gctccatcgc
     6721 aagcatagaa gtttcatcag aaatattcac agtaaatttt tgatactgtt tgatctgctc
     6781 tgcggcattc tctctcgcaa cgactccaat cacaacccaa tctcctagac tataagagga
     6841 actacaggtc gtgatgttat agccaaaatt ctaatcttga tatcctaaaa taaaaacagg
     6901 aaaaccataa tatagtttac ttgtgttaaa agattgcttc ataacaaccc cctttgacta
     6961 agacgtaaaa gaaaagccct gccatctaca tgacagggac gaatctgttt atccgcggta
     7021 ccacccaatt tcgggcagtt gcccgcaact ctcgtcttta aagcaaaaag acacttttat
     7081 ttcaattttt catccattag caaccagttt tgacacattt gtggacttct cagcgccgcc
     7141 actttctgta aaatgtggga ttcaaaacac ctctaatggc tctattgtag caagattttt
     7201 tcggaaatgc aaggctcaag aaaaattact tgaacttgat gccattttct ttcaatttct
     7261 tgatggtagc tgggccgatt cctttcaagt caaggagttc tttttcagtc cagtttttga
     7321 aatctgaagc agacttgatt ccttcatcat agaaagtctt ggcacgatca agtggaagtc
     7381 cacccaaatt tgctgcaaaa tcttctacag aattagctac tttttgagct tgctctttgg
     7441 tagcttctac tgcttgttca acttttttag aaacagcctt accagctgcg cttgctgact
     7501 gttctgcacg cttcacgact ttttttgtct catctacaac cttagtcaca gtacttgaaa
     7561 aggcacctgc gcgacggagg ccatttcgta attgtttttt acgattgagt ttctttgaca
     7621 tgataaaatc ctttcaataa aaaatccctg ctctgacaag gatttaacat aaacattcta
     7681 tcaagatttt agtgaaaaat caagaatctt tctcgtttaa taatttcgct caccaaacaa
     7741 gccttctggc aaatcatgga atcccttgcc tactttgaag ttttcaaact taccaagcaa
     7801 gaactgataa gcatccaagc gactctcgta gcgaatcatg gcatctttgg cacgctcgtc
     7861 ctggtcttct tcgtaaactt tttgactttc cttgtgcgcc atatcgttaa tcatgatttg
     7921 ggtattgacc caagcttcaa attccttcat aaattcttgt tcgtaactca ttttttctcc
     7981 ttattctaat ccacgaaaat agtccgtatc aatctcacgg tagggctgga tatcctgaac
     8041 atactccaac actccttgga attctccgtc ttcatcgtgt actgcagcat aggtgatgtg
     8101 gacaaactta cctcgcgact cagacttgaa ccacatttca tacttgtctt tgcttccctc
     8161 acgaagcccc ttcatgatag ttttgacctt gtccaagtac ttaggcggat ggcagagttc
     8221 gacattgcgc ccgacttggg acggtgtccg tttgaaaatc atctcatcag ctggcgtatt
     8281 gtcattgtaa tactggaaaa tatcttcttt attgacaaag gtaatctcca tagggagatg
     8341 attgaggatg agattggcct gctcgactga aagatagcca ttaccaaaag cctgttgact
     8401 atggcggtcc agcacagctt ccttttcctt aggggtaaag gtaatggtaa aatggccttc
     8461 tggcgtatct atgacttgtt gaacttgacc ttctgccgta tctagctgta caggttcctc
     8521 tgcaatcttt tcctcaataa agctctgtcg ttctggcacc catttctctg acggacggat
     8581 gatggcatag ccataggcat cgctctcctc cgcaatctga agccagtcat cctgagtaaa
     8641 agactcaagg agaatcatga ggaggatgga ctcttccttg aaaatcatac tttcaaactc
     8701 tgtcgcaaaa gcttcaaaag cttcctttac actgctaatt gacacttctg gtagtgactt
     8761 ggctgtcgtt agagctgttt gaaagagttc cctaatctga tcatccactc cccacataac
     8821 tttgggaggt gaatcgtgtc catagcgctc catgatagga aagaagagtt cttccttacg
     8881 ttggtaatgg atgtcaaatt gacccacaag tcccatctga cgcaccaaac ccttacgcat
     8941 ctccgccagc atttcctcgt cttccataga ctcataggta tctaacaatc tacgaatgcg
     9001 aatcaaggcc gcacggagag ccagattttc ttctttgaag acacgaactg ggtgacctgg
     9061 atgctcagta tctgaaactt cgacaccttt gatagcattt ttaaaaagat tggcatggac
     9121 atcacagagt tccataacat cttcaaaggt gacacctgac tctgagttca tcagctcgtg
     9181 ctccataagg gaaatctcaa tggctgagac acccgcaaag gtcgcatcaa aacgctcctg
     9241 aaccgactca ggagaggcgc cattatgcaa ttctaataaa atatcccgta ggacatgaat
     9301 ccgttcatct accattagtc taatccaatc acttcgtagc cattcgcttc cagtgtgcgt
     9361 acaatcttgt ccataggagt tcctgctagc ttagaacctt gtttaagtga tactttacga
     9421 ccaactgtat tgcgcatcaa gggattggca aggggtttaa aacccagctc cactagaatt
     9481 tccaagactt ctggatgctt gtccaccact tctgcaacag gaattgacac atcgatgata
     9541 ttgtccatga cgacctccat tgtatgttct aatactcaat gaaaatcaaa gagcaaacta
     9601 ggaagctagc cgcaggttgc tcaaaacacc gttttgaggt tgtggataga actgacgaag
     9661 tcagtaacat atatactgca aggtgaagct gacgtggttt gaagagattt tcgaagagta
     9721 taaaatgatt ttactgctta tattatacca tatggagaga gattaaaaaa ctagcagtgg
     9781 agttcctgct agttttctgc gacttggatt accatctaga taagtttaaa gaaccaatcc
     9841 aatatcttgt aaaacagcaa ttgaactgca aaagaaatga tcatccaaaa gaatttcaca
     9901 atcccaataa tcggtttgat aaaaagaata gcaagaattg tccagaaaaa tttcattctc
     9961 tctcctctgg cttaatgagc caccgagccg tatccattag cttatctgca ataaagagtt
    10021 ttcccagacc aacaacgaca tggtcatctt tctttatcgt tttcatcact tttacacctt
    10081 gcacggtcaa aaagtaatta ccataaattt tagcaaaagc tttgatagga ttcatattat
    10141 tctcctttga tgatttcagc ctcttttcgg attgtttcaa catcttcttg atattgaact
    10201 tcactatagt tgactagctt ggataattct ttctgcaagc tttcccccat tggtttcata
    10261 gttgcaaagg ttaaaccacc tgaaatgata ccacccaaga taggaataaa tttccccatt
    10321 cctttggcca accctccctt ggtaagattc acaccaaata tttttaagac ttttttcaaa
    10381 atagggtacc aaagcgtctt tgttaaagct ttattaggca ctgttttcat tacctgtttg
    10441 gcaattgtta taccaccagc acgtagcaaa caaagcagcg gttccattca cccctaacat
    10501 tacgcctaga taaagcaaga gggtattttg agcatcttca ctcaactcct cacgtgaagc
    10561 ccaaagatcc tcataaccat aaatataacc taattcttgg gccaatttca gagagaaacc
    10621 ataaaattga gccacataag ctggaatggt aattgccata gcaagccctc caggtaatcc
    10681 tgccaaaaca gaagtcccac tcgctaataa aacattatcc ctaatacagg cattagccac
    10741 tcgatctaag atttcttgag ataagagaga cgttggacct tgttccaata aggtaggaat
    10801 gtcctgtgga cccaattctt tggaaaactt atccactaaa aatttcgaac gatcaacctt
    10861 aacaactggt agttttacca cttgttgtaa tacttgcata gctaagtctt gttcagccat
    10921 atacaaactc cttatttctt ttttgcacct tatcatatta tatttcctac aaaaaaagca
    10981 ttttctaatt agataacatt aaaaaataca gaaccccttt tttatagtaa aataaaacaa
    11041 gaacagga
//
LOCUS       DAVHSO010000071        10983 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.072, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000071 DAVHSO010000000
VERSION     DAVHSO010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10983)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10983)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10983
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.072"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            11..733
                     /locus_tag="VVR18_001922"
     CDS             11..733
                     /locus_tag="VVR18_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEU6033392.1"
                     /translation="MIRIENLSVSYKETLALKDISLVLHGPTITGIIGPNGAGKSTLL
                     KGMLGIIPHQGQAFLDDKEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPL
                     FRSLKAKHWKKVQEALEIVGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEP
                     FAGIDSVSEEIIMNTLRDLKKAGKTVLIVHHDLSKIPHYFDQVLLVNREVIAFGPTKE
                     TFTETNLKEAYGNQLFFNGGDL"
     gene            730..1578
                     /locus_tag="VVR18_001923"
     CDS             730..1578
                     /locus_tag="VVR18_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000559784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEU6033393.1"
                     /translation="MIAEFIDGLQKFHFLQNALITAIVVGIVAGAVGCFIILRGMSLM
                     GDAISHAVLPGVALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSS
                     FLALGIILIGVAKSSTDLFHILFGNILAVQDTDMFITMGVGAAILLLIWIFFKQLLIT
                     SFDELLAKAMGMPVNFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANS
                     LKSMIFLSSTFGATASVLGLFIGYSFNVAAGSSIVLTAASFFLISFFIAPKQRYLKLK
                     NKHLLK"
     gene            1610..2539
                     /gene="psaA"
                     /locus_tag="VVR18_001924"
     CDS             1610..2539
                     /gene="psaA"
                     /locus_tag="VVR18_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding
                     lipoprotein/adhesin PsaA"
                     /protein_id="HEU6033394.1"
                     /translation="MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIAD
                     ITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTK
                     LVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSA
                     KDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVP
                     SAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQ
                     IFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLAK"
     gene            2662..3153
                     /gene="tpx"
                     /locus_tag="VVR18_001925"
     CDS             2662..3153
                     /gene="tpx"
                     /locus_tag="VVR18_001925"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol peroxidase"
                     /protein_id="HEU6033395.1"
                     /translation="MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKK
                     KVLSVVPSIDTGICSTQTRRFNEELAGLDNMVVLTVSMDLPFAQKRWCGAEGLDNAIM
                     LSDYFDHSFGHDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAA
                     KAL"
     gene            complement(3249..5957)
                     /locus_tag="VVR18_001926"
     CDS             complement(3249..5957)
                     /locus_tag="VVR18_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEU6033396.1"
                     /translation="MIKRKTYWKDLIQSFTGSKGRFLSILILMMLGSLALVGLKVTSP
                     NMEATANAYLTTAQTLDLAVMSNYGLDQADQEELKQTEGAEVEFGYLTDVTMDNGQDA
                     IRLYSKPERISTFQLRKGRLPQSDKEIALATHLQGQYSVGQEISFKEKEEGHSSLKDH
                     TYTITGFVDSAEILSQRDMGYAGSGSGTLTAYGVILPSQFDQKVYNIARLKYQDLAGL
                     NAFSSAYEEKSKQHQEELEQTLSDNGKVRLQLLKKEGQESLDKGQETLDKAQTNLQEG
                     KRRLAAAQARIQAQESQLALFPQVQREQASAQLTQAKQELGKEEDKLKQAEQNLAQEK
                     EKLEKHQQVLDDLAEPRYQVYNRQTMPGGQGYLMYSNASSSIRAVGNIFPVVLYAVAA
                     MVTFTTMTRFVDEERTHAGIFKALGYRSKDIIAKFLLYGLVAGTVGTALGSILGHYLL
                     ASVISSVITKGMVVGETQIQFYWTYSLLALVLSWLASVLPAYLVAWRELHAEAAQLLL
                     PKPPVKGAKILLERIGFIWRRLSFTHKVTARNIFRYKQRMLMTIFGVAGSVALLFAGL
                     GIQSSVAGVPSKQFQQIQQYQMLVSENPSATNQDKVELAEVLKGQEILAYQKIYSKTL
                     DKDFKGKAGLQNITLMMIEKEDLTPFIHLQHHQQELTLKDGIVITAKLAQLAGVKVGQ
                     TLEIEGKELKVAAITENYVGHFIYMSQASYEQLYGQLPQANTYLVSLRDTSATSIESQ
                     AGLLMNQSAVSSVVQNASAIRLFDSVASSLNQTMTILVIVSVLLAIVILYNLTNINVA
                     ERIRELSTTKVLGFHNNEVTLYIYRETIVLSLVGIVLGLVAGFYLHQFLIQMISPATI
                     LFYPQVGWEVYVIPVAAVSIILTLLGFFVNYYLRKVDMLEALKSVE"
     gene            complement(5959..6660)
                     /locus_tag="VVR18_001927"
     CDS             complement(5959..6660)
                     /locus_tag="VVR18_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033397.1"
                     /translation="MAYIEMKHCYKRYQVGDTEIVANRDVNFEIEKGELVIILGASGA
                     GKSTVLNLLGGMDTNDEGEIWIDGVNIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTA
                     KENVELASEIVTDALNPDQVLTDVGLAHRLNNFPAQLSGGEQQRVSIARAVAKNPKIL
                     LCDEPTGALDYQTGKQVLKILQDMSRQKGATVIIVTHNGALAPIADRVIHMHDASVKD
                     VVLNQHPQDIDSLEY"
     gene            complement(6910..9321)
                     /locus_tag="VVR18_001928"
     CDS             complement(6910..9321)
                     /locus_tag="VVR18_001928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HEU6033398.1"
                     /translation="MIRNKKQDYVLAYKQPASTTYMGWEEEALPIGNGSLGAKVFGLI
                     GAERIQFNEKSLWSGGPLPDSSDYQGGNLQDQYVFLAEIRQALEKRDYNLAKELAEQH
                     LIGPKTSQYGTYLSFGDIHIEFSQQGTTLSQVTDYQRQLNISKALATTSYVYKGTRFE
                     REAFASFPDDLLVQCFTKEGLETLDFTIELSLTCDLASNGKYEQEKSDYKECKLDITD
                     SHILMKGRVKDNDLRFASYLAWETDGDIRVWSDRVQISGASYANLFLAAKTDFAQSPA
                     SNYRKKLDLEQQVIDLVDTAKEKGYTQLKSRHIEDYQALFQRVQLDLEADVDASTTDD
                     LLKNYKPQEGQALEELFFQYGRYLLISSSRDCPDALPANLQGVWNAVDNPPWNSDYHL
                     NVNLQMNYWPAYVTNLLETVFPVINYVDDLRVYGRLAAVKYAGIVSQKGEENGWLVHT
                     QATPFGWTAPGWDYYWGWSPAANAWMMQTVYEAYSFYRDQDYLREKIYPMLRETVCFW
                     NAFLHKDQQAQRWVSSPSYSPEHGPISIGNTYDQSLIWQLFHDFIQAAQELGLDEDLL
                     TEVKEKSDLLNPLQITQSGRIREWYEEEEQYFQNEKVEAQHRHASHLVGLYPGNLFSY
                     KGQEYIEAARASLNDRGDGGTGWSKANKINLWARLGDGNRAHKLLAEQLKTSTLPNLW
                     CSHPPFQIDGNFGATSGMAEMLLQSHAAYLVPLAALPDAWSTGSVSGLMARGHFEVSM
                     SWEDKKLLQLTILSRSGGDLRVSYPDIEKSVIKMNQEKIKAKCMGKDCISVATAEGDL
                     VQFYF"
     gene            complement(9374..10066)
                     /locus_tag="VVR18_001929"
     CDS             complement(9374..10066)
                     /locus_tag="VVR18_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate mutase"
                     /protein_id="HEU6033399.1"
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIK
                     EAGIEFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAA
                     EQFGDEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERAL
                     PFWEDKIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDE
                     KLNVVSEYYLGK"
     gene            complement(10601..10981)
                     /locus_tag="VVR18_001930"
     CDS             complement(10601..10981)
                     /locus_tag="VVR18_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000769852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033400.1"
                     /translation="MKLKTLALISGIVGLVGGILLLIGPFVLLGTTVNTAATTLNGGA
                     TAGTFSGVALLLNALKIANLVLGIIAIVYYKGDKRVGAAPSVLMIVSGGVSLIPFLGW
                     VGGILAIIGGSLFLATLKKFKSEE"
BASE COUNT         3210 a         2524 c         2053 g         3196 t
ORIGIN      
        1 atacaagttt atgatacgta tcgaaaacct cagtgtctcc tacaaagaaa cgttggcact
       61 taaggatatt tcactagtgc tccatggacc aacaattacc ggcatcattg gtccaaacgg
      121 cgctgggaaa tcaacactat taaaaggtat gctgggaatt atcccacatc aaggtcaggc
      181 atttctcgat gacaaggaag ttaaaaaatc cttacaccga attgcctatg tcgaacaaaa
      241 aatcaatatc gactacaact ttcccatcaa ggtcaaggaa tgcgtctcgt taggactatt
      301 tccctctatt cctctctttc gaagtttaaa ggctaaacat tggaagaaag tgcaagaggc
      361 ccttgaaatc gtcggcctag ctgactacgc tgaacgtcaa attagtcaac tgtctggagg
      421 tcaattccag cgggtcttga ttgccagatg tttggtgcag gaagccgact atatcctctt
      481 ggatgaaccc tttgctggga ttgactctgt cagtgaggaa atcatcatga atacgctgag
      541 agatttgaaa aaagctggga agacggttct catcgttcac cacgacctca gcaagattcc
      601 ccactacttc gatcaagtct tacttgtcaa tcgagaagtg attgcctttg gtccaacaaa
      661 agaaactttt accgaaacca atctaaaaga agcttacggt aatcaactct ttttcaatgg
      721 aggtgaccta tgattgcaga atttatcgat ggattgcaaa aattccattt cctacaaaat
      781 gccttgataa cagctattgt cgtcgggatt gtagctggag ctgtgggatg tttcattatt
      841 ctacgcggga tgtcactcat gggagatgcc atttcacatg ctgtcttacc aggtgtagcc
      901 ctctccttca tcttgggcct tgacttcttt atcggagcca ttgtctttgg attgctagct
      961 gccatcatca ttacctacat caaaggaaac tcgattatca aaagcgatac cgccatcggc
     1021 attacctttt cttctttctt agccctcggt atcatcttga ttggtgtcgc taaaagttca
     1081 actgaccttt tccatatcct ttttggtaat attctggccg tccaagatac ggatatgttt
     1141 attactatgg gtgtgggggc agccatcctc ttgttaattt ggattttctt caagcaactc
     1201 ttgataactt cctttgatga actcttggct aaagccatgg gaatgcctgt caatttctat
     1261 cactaccttc tcatggtact cctgactctc gtgtctgtga cagccatgca aagtgtcgga
     1321 actatcctga ttgtagccat gctgattacc ccagctgcaa ctgcttatct gtatgctaat
     1381 agtctgaaaa gtatgatttt cctttcctca accttcggag ctactgcttc agttttggga
     1441 ctctttattg gctatagttt taatgttgcg gcaggttcta gtatcgtgct tacagctgct
     1501 agtttctttc tcattagctt ctttatcgct cccaaacaac gatatttgaa actgaaaaat
     1561 aaacatttgt taaaataagg ggcaaagccc taataaattg gaggatctaa tgaaaaaatt
     1621 aggtacatta ctcgttctct ttctttctgc aatcattctt gtagcatgtg ctagcggaaa
     1681 aaaagataca acttctggtc aaaaactaaa agttgttgct acaaactcaa tcatcgctga
     1741 tattactaaa aatattgctg gtgacaaaat tgaccttcat agtatcgttc cgattgggca
     1801 agacccacac gaatacgaac cacttcctga agacgttaag aaaacttctg aggctgattt
     1861 gattttctat aacggtatca accttgaaac aggtggcaat gcttggttta caaaattggt
     1921 agaaaatgcc aagaaaactg aaaacaaaga ctacttcgca gtcagcgacg gcgttgatgt
     1981 tatctacctc gaaggtcaaa atgaaaaagg aaaagaagac ccacacgctt ggcttaacct
     2041 tgaaaacggt attatttttg ctaaaaatat cgccaaacaa ttgagcgcca aagaccctaa
     2101 caataaagaa ttctatgaaa aaaatctcaa agaatatact gataagttag acaaacttga
     2161 taaagaaagt aaggataaat ttaataaaat ccctgctgaa aagaaactca ttgtaaccag
     2221 cgaaggagca ttcaaatact tctctaaagc ctatggtgtc ccaagtgcct acatctggga
     2281 aatcaatact gaagaagaag gaactcctga acaaatcaag accttggttg aaaaacttcg
     2341 ccaaacaaaa gttccatcac tctttgtaga atcaagtgtg gatgaccgtc caatgaaaac
     2401 tgtttctcaa gacacaaaca tcccaatcta cgcacaaatc tttactgact ctatcgcaga
     2461 acaaggtaaa gaaggcgaca gctactacag catgatgaaa tacaaccttg acaagattgc
     2521 tgaaggattg gcaaaataag cctctgaaaa acgtcattct catgtgagct ggcgtttttt
     2581 ctatgcccac atttccggtc aaatcattgg aaaattctga ctgtttcaga tacaatggaa
     2641 gaaaaaagat tggagtatcc tatggtaact tttctcggaa atcctgtgag ctttacaggt
     2701 aaacaactac aagtcggcga caaggcgctt gatttttctc ttactacaac agatctttct
     2761 aaaaaatctc tggctgattt tgatggcaag aaaaaagtct tgagtgtcgt tccttctatc
     2821 gatacaggca tctgctcaac tcaaacacgt cgttttaatg aagaattggc tggactggac
     2881 aacatggtcg tattgactgt ttcaatggac ctaccttttg ctcaaaaacg ttggtgcggt
     2941 gctgaaggcc ttgacaatgc cattatgctt tcagactact ttgaccattc tttcgggcac
     3001 gattatgccc tcttgatcaa cgaatggcac ctattagcac gcgcagtctt tgtcctcgat
     3061 actgacaata cgattcgcta cgttgaatac gtggataata tcaattctga gccaaacttc
     3121 gaagccgcaa ttgcagctgc taaagcccta tagaaaaaat cctctgtcac aaagagttcc
     3181 ctgctctttg aaacggagga tttttgaata ttagtaaata gaagttcaat cagctaaaaa
     3241 taactacctt actctacaga tttcagggct tctaacatat caacctttct cagataataa
     3301 ttgacgaaga aaccaagcaa ggtcaaaatg atgcttactg ctgccactgg gattacatag
     3361 acttcccagc ctacctgcgg ataaaagaga atagtcgcag gcgaaatcat ttgaatcaaa
     3421 aattggtgta aatagaaacc agctaccaga ccaagtacga ttcccacaag ggatagcaca
     3481 atcgtctcac ggtaaatgta gagggtgact tcattattat gaaaaccaag aaccttggta
     3541 gtggagagtt cacggattct ctcagctacg ttgatattgg tcagattgta aaggatgaca
     3601 atagctaata gaaccgatac gatgaccaag atggtcatgg tctgattgag tgagctagcg
     3661 acagagtcga agagtcgaat ggctgaagca ttttggacaa cgctggacac cgcagattga
     3721 ttcataagca agcccgcctg actttcgata ctagttgcac tggtatccct taatgagacc
     3781 agataagtgt tggcttgggg tagctgtccg taaagttgct catagctagc ctgactcata
     3841 taaataaagt gaccaacgta gttctcagta atagcagcga cctttagttc cttaccttca
     3901 atttctaaag tctgcccaac cttgacacct gccagctggg cgagtttagc tgtaataacg
     3961 atgccatctt ttaatgtcag ctcctgctga tgatgttgaa gatggataaa gggagtcaaa
     4021 tcttccttct ctatcatcat aagagtaatg ttttgaagac cagccttgcc tttgaaatcc
     4081 ttgtctagcg ttttagaata gattttctgg taggctagta tctcctgccc tttcaacact
     4141 tctgctagct ctaccttgtc ctgattggtc gcactaggat tttcagagac aagcatctga
     4201 tactgttgga tttgttgaaa ctgtttagac ggaactcctg ctacagaaga ttggattccc
     4261 aaacctgcaa agagcagagc tacagaacct gccacaccaa agattgtcat caacattctc
     4321 tgcttataac gaaagatgtt gcgggctgtt accttatgag taaaactgag acgacgccag
     4381 ataaaaccga tacgctccaa taagatttta gctcctttga caggaggttt aggaagtaga
     4441 agctgggctg cttcggcatg aagttccctc caagccacca gataggctgg taacacactc
     4501 gccaaccagc tcaagacaag agctagtaag ctataggtcc aatagaactg aatctgggtt
     4561 tctcccacca ccatgccttt tgtaatgaca cttgaaatta cactggctag caaataatga
     4621 ccaagtatac tacctagagc cgttccgaca gtcccagcta ctagtccata aaggagaaac
     4681 ttggcgataa tatccttact acggtaaccc aaggccttaa aaatccctgc atgagttcgc
     4741 tcttcgtcta caaagcgagt catggtcgta aaggtcacca tggctgctac ggcataaagt
     4801 accacaggaa agatattgcc cactgctcga atactggatg aagcattgct atacataaga
     4861 tagccctgac cacctggcat ggtctgacga ttatagacct gataccttgg ctccgccaaa
     4921 tcgtccaaga cttgctgatg tttttctaat ttttcctttt cttgggctag attttgttca
     4981 gcttgcttta gtttatcctc ttccttgccc aattcctgct tggcttgggt aagttgagca
     5041 ctagcctgct ctctctgaac ttgaggaaac aaggctagtt gactttcttg agcctgtata
     5101 cgagcttgag cagctgctaa acgacgcttg ccttcctgca aattagtctg agccttgtca
     5161 agggtctctt gccccttgtc tagagactct tgtccttctt ttttcaaaag ttgcagacgt
     5221 accttgccat tatctgataa agtttgttca agctcttcct gatgttgctt ggatttttct
     5281 tcataagctg atgaaaaggc atttaaacct gctaaatctt gatatttcaa acgagctata
     5341 ttgtagactt tctgatcaaa ctgactaggt aaaatcaccc cataggctgt cagagtccca
     5401 cttccacttc ctgcgtagcc catatctcgc tgggagagga tttcagccga atccacaaaa
     5461 ccagtaatgg tataagtatg gtcttttaaa gaggaatgac cctcttcttt ttctttaaaa
     5521 ctaatctcct gtcccacgct gtattggcct tgcaaatgag tggccaaagc gatttccttg
     5581 tctgactgag gaagtcgtcc ctttcttagc tgaaaggttg aaattcgctc tggtttggag
     5641 tacagccgaa tggcatcctg cccattatcc atagtcacat ctgtcaaata gccaaactcg
     5701 acctctgcgc cctccgtctg ttttagttct tcttggtctg cttgatccaa gccatagtta
     5761 gacatgactg ccaaatccaa ggtttgagca gttgttaaat aagcattagc tgtcgcctcc
     5821 atgttgggac tggttacttt gaggcctact aaggctagag atcccaacat catcaggatc
     5881 aagatggata aaaaacgccc cttggagcct gtgaaggact gaattaagtc cttccaataa
     5941 gtttttcgct tgatcatgct agtactccaa actgtcaata tcctgaggat gttggttgag
     6001 caccacatcc ttgacactgg catcgtgcat atgaatcacg cgatcagcaa tgggcgccaa
     6061 agctccatta tgagtcacga tgatcaccgt cgctcccttt tgacgagaca tatcttggag
     6121 aattttcaaa acctgcttgc ccgtctgata atccaaggct ccagtaggtt catcacaaag
     6181 aagaatttta ggatttttgg ctaccgcgcg tgcaatggag actcgctgtt gctcccctcc
     6241 agaaagctgg gctggaaagt tattgagacg atgagccaga cctacatctg tcaagacctg
     6301 atcaggattc aaggcatctg tcacaatttc agaagccagt tccacatttt ccttagctgt
     6361 cagattagaa actagattat aaaactgaaa aacaaacccc acatcatttc tacggtaatt
     6421 ggtgcgctgg tgggaactat aatccgcaat attaacacca tcaatccaga tttccccttc
     6481 atcattggta tccattcccc caagaaggtt aagaactgtt gacttgcctg cacctgaagc
     6541 accaaggata ataaccagct cccccttttc aatctcaaaa ttcacatcac gattggccac
     6601 aatctccgtg tccccaacct gataacgctt gtaacagtgt ttcatctcaa tataagccat
     6661 cagacccacc ctctatcaaa caaattatac tcctcgaaaa tctctcttca aaccacgtca
     6721 gcttccatct acaacctcaa aacactgttt tgagcaacct gcggctagct tcctagtttg
     6781 tgctctttga ttttcattga gtattacttc ctattatcat tataacgctt tttcaactag
     6841 ttggaaactg cctatattct caaatcctta ttaaaaggaa gtttcaaatt actgccttat
     6901 aacatcttct taaaaataaa attgaacaag atcaccttct gctgttgcca ccgaaataca
     6961 atctttcccc atgcatttcg cttttatttt ttcttgattc attttaatca cactcttctc
     7021 aatatctgga taagaaactc gcaaatctcc tccactcctt gataaaatgg tcaactgtaa
     7081 gagtttttta tcttcccagc tcatgctcac ttcaaaatgt ccacgtgcca ttaagcctga
     7141 aacagaacct gttgaccaag catcaggtag ggcagctaga ggtaccagat aagctgcatg
     7201 agactggagt aacatttctg ccatgccact agtagcacca aaattaccat ctatctgaaa
     7261 aggaggatgg ctacaccaaa gatttggcaa ggtggatgtc tttaactgct ctgccaataa
     7321 tttatgggct cgattgccat ctcccaaacg cgcccagaga ttgatcttat tagccttgga
     7381 ccagcctgtg ccgccatctc cacgatcatt gaggctagca cgcgccgctt caatatactc
     7441 ttgtcccttg tagctaaaga gattgccagg atagagtccc actagatggg aagcatgccg
     7501 atgctgggcc tccactttct cattttgaaa atactgctct tcctcctcat accactccct
     7561 gattcgacca gattgagtga tttgcaaagg atttagtaaa tcagacttct ccttaacctc
     7621 agtcaacaag tcctcatcca gtcccaattc ctgagcagcc tgaataaaat catgaaataa
     7681 ctgccaaatc agagattggt cataagtatt gccaatcgaa atcggcccat gttctgggga
     7741 ataagacgga gaagacaccc aacgctgcgc ctgctgatcc ttatgtaaaa aggcattcca
     7801 aaaacaaacc gtttccctca acatgggata aattttctct ctgagatagt cttggtccct
     7861 ataaaatgaa taggcttcat aaacggtttg catcatccac gcattggcag ctggtgacca
     7921 accccaatag taatcccaac caggtgccgt ccaaccaaag ggagtcgctt gagtatgaac
     7981 caaccaacca ttctcctcac ctttctgaga gacgattcct gcatacttta cagccgctag
     8041 acgaccatag acacgcaaat catctacata gttgatgact ggaaagaccg tctctaggag
     8101 attggtaaca taggctggcc aataattcat ctgcagattg acatttaagt gatagtccga
     8161 attccaagga ggattgtcga ccgcattcca gactccctgt aggttagctg gtagagcatc
     8221 tgggcagtct ctggacgaac taatcaataa ataccgtcca tactggaaga acagctcctc
     8281 caaagcctgc ccttcttgtg gcttataatt ttttaacaaa tcatctgtag tggatgcgtc
     8341 aacatcagct tccaaatcca attgaacacg ctggaataag gcttggtagt cctcgatatg
     8401 ccttgatttc aattgggtat agcccttttc tttagctgtg tccaccaagt ctatcacctg
     8461 ttgctctaaa tctagtttct tgcgataatt gctagcagga ctttgggcaa aatccgtctt
     8521 agcggccaag aagagattgg cataactggc tcctgatatc tgaaccctat ctgaccaaac
     8581 tctaatatct ccatccgttt cccaagctag ataactagca aaccgcagat cattatcctt
     8641 aactcttccc ttcatcaaga tatgagaatc agtaatatcc aacttacact ccttgtaatc
     8701 agatttttcc tgctcatact ttccattaga agccaaatca caggtcaagg atagttctat
     8761 agtaaaatct agagtttcca acccttcctt agtaaaacat tgaaccaaga gatcatctgg
     8821 aaaactcgca aaagcttcac gttcaaatcg cgttccctta tagacataag aagtcgtcgc
     8881 aagtgcctta ctaatattca actgtctctg atagtccgtc acctgagaca aagtcgtacc
     8941 ttgctggctg aactcaatgt gaatatcccc aaaagacaga taggtcccat attgactcgt
     9001 ttttggccca attaggtgct gctcagccag ttccttagcc agattgtaat ctctcttctc
     9061 caaagcctgc cgaatctcag ctaaaaaaac atactgatcc tgaagatttc caccctgata
     9121 atctgaacta tcaggaagtg gacctccaga ccagagactt ttttcattaa attgaatccg
     9181 ttcagcccct ataaggccaa atacttttgc tcctaaagaa ccattaccta tcggtaaagc
     9241 ttcttcttcc caacccatgt aagtggttga agctggttgc ttgtaggcca gtacataatc
     9301 ttgtttttta ttccttatca tacttccata ctaacataaa aagcctagaa atcaatccta
     9361 ggcttacaat tttttatttt ccaaggtagt attcagaaac aacgttcaat ttttcatcga
     9421 attcgaatac caatggtggg aagttaggga tttccacgtc catgatctca tcatctgaca
     9481 aacctttgat gtgttttaca agggcacgga ttgagttacc gtgagctcct acgaatacgt
     9541 ttttaccatc tttaagagct ggagcgattt tatcttccca gaatggaaga gcacgttcca
     9601 aagtcacttt caagttttca gcatctggga ttactgagtc gtcaagtgaa gcataacgac
     9661 ggtctgtgtg agctgagtgc tcatcatcac ggtccatatt tggaggcaat acatcgtatg
     9721 aacgacgcca gatgtgaact tgctcatcac caaattgttc agcagcttca gctttgtttt
     9781 taccagtcaa accaccgtag tgacgttcgt tcaagcgcca tgatttttca actggaaccc
     9841 ataattggtc agaagcttca agagccaagt tagttgtttt gatagcacgt ttcaatactg
     9901 aagtgtaagc ttggtcaaat tcgataccag cttctttgat caatttacca gcgtcaatcg
     9961 cttgttgtgt acctttttca gacaaatcaa catcagccca accagtgaaa aggttagctt
    10021 tgttccattc agactcaccg tggcgagcaa aaaccaattt taccattaga tggattctcc
    10081 tttaaatttt ccgaggtttc ccctcgttta tctattctat tttacacaat ttttcacaaa
    10141 aaagctagtc aaaaccaaaa aggaaaggac tgtttgacaa tgtttggcaa tcacattgtt
    10201 tttggctgtt tctattctat cttcattatt taaccttttt ttctgcgcat cgaataattt
    10261 ttgagttgac tcttttagtt tagtaaacga gtcattattt tccatagctg tgcctttgaa
    10321 accttcctca gctttagtaa aataatcatc aaaaatattt ttataaagat ctatataatc
    10381 tgcataagtg cgtattgatt caatcgcatc gtctgttaca accggtgtat cgaaagtgat
    10441 tgtttctttt gaactattgg atgttgctac tgtcttctca tcattacttg ttgaagtatt
    10501 ctttgaactt tatgttccac atgcaactag aagagaaaga gataatagag ctactcctat
    10561 accgataaac ttttttgttc ttttcatgct aaaatacctt ttattcttct gatttgaatt
    10621 tcttcaatgt tgcaaggaat agagatcctc cgataatagc aagaatcccc ccaacccatc
    10681 ctaagaatgg aatgagacta actccaccag aaacaatcat tagtacagac ggagctgcac
    10741 ctacacgctt atctccttta tagtaaacaa tagcaatgat accaagaaca agatttgcaa
    10801 tcttcaaggc attcaagagt aaggcaacac ctgaaaaagt ccctgcagta gctcctccat
    10861 taagagttgt agcagctgtg tttaccgttg ttcccaacaa gacaaaagga ccaataagaa
    10921 gtaaaattcc tcccacaaga ccgacgatac cactaattaa agcaagtgtt tttaatttca
    10981 taa
//
LOCUS       DAVHSO010000072        10945 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.073, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000072 DAVHSO010000000
VERSION     DAVHSO010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10945)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10945)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10945
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.073"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            31..1143
                     /locus_tag="VVR18_001931"
     CDS             31..1143
                     /locus_tag="VVR18_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001260074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6033401.1"
                     /translation="MRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTLFSPFS
                     TRLAQKIGLEHLFTYNLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQA
                     NQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPN
                     HRYNHRLAPQTKQKSQIKVMCNKQVWAIIIFSGFQSLIFYTVMTWLPTMSIHAGLSSH
                     EAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVVGISMLFFPINNFI
                     YWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGY
                     SFDLFHSWVPAVAALLLIDILMTVALFTVDRADKIL"
     gene            1282..1608
                     /locus_tag="VVR18_001932"
     CDS             1282..1608
                     /locus_tag="VVR18_001932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEU6033402.1"
                     /translation="MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLY
                     PILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGS
                     IRHDKN"
     gene            1595..2188
                     /locus_tag="VVR18_001933"
     CDS             1595..2188
                     /locus_tag="VVR18_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HEU6033403.1"
                     /translation="MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEEL
                     IASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILV
                     TLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTVLAQAKSAFILIFGSGLLAIGA
                     SSLVLLGISYVARFFGLLIVRLVQFVLKKRKRGNQHA"
     gene            2181..3092
                     /locus_tag="VVR18_001934"
     CDS             2181..3092
                     /locus_tag="VVR18_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 domain-containing protein"
                     /protein_id="HEU6033404.1"
                     /translation="MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVY
                     DSRTEKLTFGKEVENLEITLHQHTLTITDSFDDQIHISYHPSLSAHHDLITNQNDRTL
                     SLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILRLPKGRTLKGINISANRGQTTI
                     INASLENANLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTDNHFHAEN
                     IQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYK
                     TEKTDVKDQLIARSDDNIDLISTPSRR"
     gene            3155..4219
                     /locus_tag="VVR18_001935"
     CDS             3155..4219
                     /locus_tag="VVR18_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033405.1"
                     /translation="MKQEWFESNDFVKTTSKNKPEEQAKEVADKAEETIADLDTPIGK
                     NTQVEEEVSQAEVELESQQEEKIETPEVGEARTEIEEKKASNSTEEEPDLSKETEKVT
                     IAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEAIK
                     SPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLT
                     LFSIISTLVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIA
                     SFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIIL
                     LFFVAEVALIGDYLRILAFL"
     gene            complement(4397..5257)
                     /locus_tag="VVR18_001936"
     CDS             complement(4397..5257)
                     /locus_tag="VVR18_001936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4299 domain-containing protein"
                     /protein_id="HEU6033406.1"
                     /translation="MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQ
                     PLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTKTDWLIIKSFLDALLAYT
                     GTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLA
                     QFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLV
                     DKEVQWEIDLVQITGDGSKPEDYESIARLDYAKFLEVLPPSFYHQLDANQIEIQPILG
                     QDFKTLAQEK"
     gene            complement(5379..6365)
                     /locus_tag="VVR18_001937"
     CDS             complement(5379..6365)
                     /locus_tag="VVR18_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-related sulfurtransferase"
                     /protein_id="HEU6033407.1"
                     /translation="MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADE
                     GINGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEENEQAFKKMFVRYKKEIVHLGLE
                     DNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRN
                     FRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKD
                     PEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILT
                     SEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV"
     gene            complement(6637..8112)
                     /locus_tag="VVR18_001938"
     CDS             complement(6637..8112)
                     /locus_tag="VVR18_001938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3502 domain-containing protein"
                     /protein_id="HEU6033408.1"
                     /translation="MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIK
                     MYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAF
                     ADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQ
                     NFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPV
                     ANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQD
                     TWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEK
                     SMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNW
                     ILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINT
                     GTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK"
     gene            complement(8322..9245)
                     /locus_tag="VVR18_001939"
     CDS             complement(8322..9245)
                     /locus_tag="VVR18_001939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001075101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU6033409.1"
                     /translation="MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVF
                     VIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNV
                     FITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVP
                     MLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTA
                     LGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMA
                     MVVVATLPIAILYPFFQRYFVKGLTIGGVKE"
     gene            complement(9259..10188)
                     /locus_tag="VVR18_001940"
     CDS             complement(9259..10188)
                     /locus_tag="VVR18_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU6033410.1"
                     /translation="MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYH
                     MTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAII
                     LSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFY
                     ADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIP
                     QLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGM
                     AAAAGLYQSVVGLILVILSNLLARRVDPNSALF"
     gene            complement(10507..10728)
                     /locus_tag="VVR18_001941"
     CDS             complement(10507..10728)
                     /locus_tag="VVR18_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033411.1"
                     /translation="MTGVSNPTTDSAPLVLAEAKKAFADDSLIEQGLRDILQTVKDAI
                     ASLESIKESQSATKIDNLKEVIAKLKANA"
BASE COUNT         3227 a         2362 c         2069 g         3287 t
ORIGIN      
        1 gttccaggta ttatcctgat tggtgtttcc ttgcgaactc cttttactgt tttacccatt
       61 attttgggaa atatttcgca aggtctggag gtagaagtta gttcgcttgg tgtcttgacc
      121 agcctgcctc tccttatgtt taccctcttt tcaccatttt ctacccgact ggctcagaaa
      181 attggcttgg agcatctctt cacctacaac ctcttcttct tgaccatcgg ctcacttatt
      241 cgactaatca atctgcccct gctctatcta ggaaccttga tggttggggc aagtgtcgca
      301 gtcatcaatg tcctgcttcc tagtcttatc caagccaatc aaccaaagaa aattggtttt
      361 ctgaccacct tatatgtaac gtctatgggg attgcaacgg ctctggcttc ctatctagct
      421 gtgcccatta cacaagccag ttcttggaaa ggacttatcc tcctcctcac gttactctgt
      481 ctagcaactt ttttggtctg gctcccaaat caccgctata atcatagact agctccacaa
      541 accaaacaaa aaagtcaaat aaaggtcatg tgtaataaac aggtttgggc aattattatc
      601 ttttcaggtt ttcaatcctt gatcttttac accgtcatga cctggttacc taccatgtct
      661 atccatgcag gtctatccag tcacgaagct ggcttgctga cttctatctt atctctgatt
      721 agcattcctt tttcaatgac catcccaagc ctgacaacca gtttatctac tcgcaaccgt
      781 cagctcatgc tcactctggt ttcactagct ggtgtggtcg gcatttccat gctctttttc
      841 ccaatcaata atttcattta ctggcttgcc atccatctcc tcatcggaac cgcaaccagc
      901 gccctcttcc cttatctcat ggtcaacttt tcactcaaga caagcgcccc tgaaaagaca
      961 gcccaattgt ccggtctatc tcaaacagga ggctatatcc tagcagcctt tgggccaacc
     1021 ctctttggtt acagttttga cctgttccac tcttgggtac cagctgtagc tgccctcttg
     1081 ctcatcgata tcctgatgac tgtggccctc tttacagtgg acagagcgga taagatcctt
     1141 taaacttcta gttttagcta gaagtttttt atatataaaa attttacaca tttctcttga
     1201 cagggctttc ttttagatgt acaatatatg tgtagaaaaa ttatatataa aaatcttaca
     1261 cattagaaaa ggaggtttcc catgtacttt ccaacatcct ctgccttgat tgaatttctc
     1321 atcttggccg tactggagca gggtgattct tatggttatg agattagcca aaccattaag
     1381 ctgatcgcta atatcaaaga atccacactc tatcccattc tcaaaaaatt ggaaggcaat
     1441 agctttctga caacctattc tagagagttc caaggtcgca tgcgcaaata ctactccttg
     1501 acaaacggtg gtatagagca gctcttgacc ctaaaagatg aatgggcact ctatacagac
     1561 accatcaatg gcatcataga agggagtatc cgccatgaca agaactgaat acctgactca
     1621 gctagaactc tatctcaaga aactacctga agctgaccgt atcgaagcca tggactattt
     1681 cagagagctc tttgacgatg ctggagtcga aggagaagaa gaactcatcg ctagtttggg
     1741 aactcccaaa gaagcggccc acgaagttct atccaatctt ctcgataaaa aaatcaatga
     1801 agcacccgct caaaaaaata accgacaaat tttacatatc gccttgttag ccctccttgc
     1861 agcacctatc ggcattcctc tgggaatcgc catcctcgtg accctgttcg caatccttgt
     1921 agccgctttg actgtcattc tggctttctt tgcagtttcc atactgggta tcatcggcgg
     1981 attcctattt ttagttgaaa gtttcactgt cctcgcccaa gccaaatcag cctttatctt
     2041 gatttttggt tctggtttac tggctatcgg tgcttcttcg ctagttttac taggcatttc
     2101 ctatgtagct cgcttcttcg gtctactcat tgttcgcctg gtacaatttg ttcttaaaaa
     2161 aagaaagaga ggtaaccagc atgcgtaaat ggacaaaagg atttctcatc tttggtgtgg
     2221 tgactaccgt tatcggcttt atcctgcttt ttgtaggtat ccaatctgac gggattaaga
     2281 gcctactttc catgtccaaa gaacctgtct atgatagccg tacggaaaag ctaacctttg
     2341 gcaaggaagt cgaaaaccta gaaattactc tccaccaaca cacgctcacc atcacagact
     2401 ctttcgatga tcaaatccac atttcttacc atccatctct ttctgctcac catgatctta
     2461 tcaccaatca gaacgataga actctgagtc tcactgataa gaaactgtct gaaactccgt
     2521 ttctctcttc tggaattggt gggattcttc atatcgcaag tagctactct agtcgttttg
     2581 aagaagttat tctccgacta ccaaaaggga gaactctaaa agggatcaac atctcagcca
     2641 atcgcggaca aaccaccatc ataaatgcta gccttgaaaa tgcgaacctc aatacaaaca
     2701 gctatatcct ccgaattgaa ggaagtcgta tcaaaaacag taaactcaca acgcccaata
     2761 tcgttaatat ctttgataca gttcttacag atagtcagct agagtcaaca gataatcact
     2821 tccacgctga aaatatccaa gtccatggta aggttgaact gactgccaaa gattatctca
     2881 gaatcatcct agaccagaaa gaaagccaac gaattaactg ggacatctca agcaactatg
     2941 gttctatctt ccaattcaca agagaaaagc ctgaatcaag aggtacggaa ttaagcaacc
     3001 cttacaaaac tgaaaaaacc gatgtcaagg atcaactcat tgcgagatct gatgataata
     3061 ttgatctaat atccacacca agcagacgtt gacaaaaacg cttacatctg ctactatgga
     3121 agcatattta tctaactaaa aaggaggttc taccatgaaa caagaatggt ttgaaagtaa
     3181 tgattttgta aaaacaacaa gcaagaacaa gcctgaagag caagctaaag aggttgcaga
     3241 caaggctgaa gaaacgatag ccgatctcga tacaccaatt ggaaaaaata ctcaagtaga
     3301 ggaggaagtc tctcaagctg aagtcgaatt ggaaagccag caagaagaga aaattgaaac
     3361 tcctgaagtc ggtgaagcga gaacagaaat agaagaaaag aaggcatcta attctactga
     3421 agaagagcca gacctttcta aagaaacaga aaaagtcact atagctgaag agagccaaga
     3481 agctcttcct cagcaaaaag caaccacgaa agagccactt cttatcagta aatctttaga
     3541 aagtccttat atccccgacc aagctccaaa atctagggat aaatggaaag agcaagtgct
     3601 tgatttttgg tcttggctag tggaagcgat caaatctcct acaagtaagt tggaaacaag
     3661 tatcacacac agttacacag cctttctctt gctcattctg ttttctgcat cttccttttt
     3721 ctttagtatc tatcacatca aacatgctta ctatggacat atagcaagca ttaacagtcg
     3781 cttccctgag cagctagctc ctttaactct tttttctatc atctctaccc tagtagcgac
     3841 aacactcttc ttcttttcat tcctcttggg tagtttcgtt gtgagacgat ttatccacca
     3901 ggaaaaggac tggacgctag acaaggttct ccaacaatat agtcaactct tggcaattcc
     3961 aatcttcctc actgctattg ctagtttctt tgctttcttt gatagcctac gatttacagc
     4021 tctcttgtgt gtgattagca ttggaatcat tctgcttgcc agtctccata tcattacaag
     4081 accaagtcaa gcaagtgaaa ccgactcctt ctatcaatta ttcttgtctg tccttgtgaa
     4141 cggagttatt atcctcctct tctttgtagc tgaagtggca ctgattggag attatcttcg
     4201 tatcttggcc tttctttaaa cttcatactc ttcgaaaatc aaattcaaac cacgtcagct
     4261 tcgccttacc gtactcaagt acagcctgcg gctagcttcc tagtttgctc tttgattttc
     4321 attgagtagc aatcctgtca ttcttggcag gattttttct atgtcaaaaa agcaagtcga
     4381 ttgacctgct tctgctttac ttttcttgtg ctaatgtttt aaaatcttgt cctaggatgg
     4441 gttgtatttc tatttgattg gcgtctagtt ggtggtaaaa agatgggggt aatacctcta
     4501 agaattttgc atagtccaag cgagctatgg attcatagtc ttctggttta gagccgtctc
     4561 ctgtgatttg aaccaagtca atctcccact ggacttcctt atccaccaat tgctcaatat
     4621 aggctgcagg aacaaacggt tctctcggta aaactgtctt gactccttga gctagatggt
     4681 aaacgccatg cacttttcct tctccatcct gatagaagga aactctcgca aagtaggcat
     4741 ctgtctcttg aaccgcacgc acacgcgctt caaactgagc caagccatct gcctctaaaa
     4801 agcttttcaa gttctcacga ctaaagaaaa taggattaaa aattccttgg caaatcgtaa
     4861 aacgagctac agggtctgct agataggctt gaatacttgc ttggaaataa gcttcaaaat
     4921 caaaaccatc tagcccttca atatcagtcc ctgtataagc aagcaaagca tctaaaaatg
     4981 acttgataat cagccagtct gtctttgtta gtaggtcagg aagatcgaca cggtaagcct
     5041 tttgaccatc agcataactg accttaaaaa gaaattgtga ttgccccact atcgcacact
     5101 caatatattc gagacgatta agaggctgac ggagatagac tacatcatag ctatgtgact
     5161 ccaaaccgtc tagcaaggcc aagatcgatt tggcattcaa aatctcttgt tctcctaaaa
     5221 tgctctgttt atttggaata aaaaatgttt tcgccataac tggactcctt tgaaatcgct
     5281 tacatacagt ataccttatt tttctgaaag atacagaaac aaactttaga tttttgagta
     5341 caaagcatag aaaaacagcc cctgaggact gtttgatctt atacagtagc tgcttgatcc
     5401 aagctttcac cgatagcggc taggcgctcg atcacttcag cttgtgtcaa ttcatttttt
     5461 gaaacatagc ggttacgtgg gtgaacacgg cactcgtgtg agcatccacg aaggtacttg
     5521 tcttcatttt cttctgatgt caagatacga cggttacaga agggatttcc acagttgaca
     5581 taacgttcac atggcgttcc atcaaaccag tctttcccta cgatagttgg gttgacatgg
     5641 ttgacatcaa cggcaatacg ctcgtcaaag acgtacattt tcccatccca aagctcacct
     5701 tgaacttctg ggtctttacc gtaagttgcg attcctccgt gcaattggcc aacatctttg
     5761 taaccttcac gaaccatcca gcctgagaat ttctcacagc gaacaccacc tgtacagtaa
     5821 accacgacac gcttgtccat gaatttttct ttgttgtcac ggacccattg tggtaactca
     5881 cggaagttgc gaatatctgg gcgaatagcc ccacggaaat gtcctaggtc gtactcataa
     5941 tcgttacgtg tgtcaaggac aacggtatct ttatcaagaa gcgcttcttt gaactctttt
     6001 ggagacaagt aagcacctgt tgtttcaagt gggttgatgt cattgtcaaa gtcgttgtct
     6061 tccaaaccaa ggtggacaat ttctttcttg tagcgaacaa acatcttctt gaaggcttgt
     6121 tcattttctt cgtcaatctt gaaccagaga tcttccattc ctggaaggct gtgaacgtag
     6181 tccatgtatt tttgagttgt ttcatagtca cctgaaactg ttccgttaat tccctcgtca
     6241 gcgactagga tacggccttt aaggccgatt gatttacaga aagccaagtg gtctgcagca
     6301 aattgctctg cattttcaat tggagtataa aggtagtaaa gtaagacacg aatatctttt
     6361 gccataagat ttgttctctt ttctattctt aaattttcta aattttttat ttatccatac
     6421 tagtatacct gcttgagaaa acgaatgcaa tttatttgac tggaaattgt agagggttct
     6481 cgaaatttcc tgaatggtta aaataaggac aagagaaaac atggatatct atatccttgt
     6541 gccaaaaaaa ccactgccct ccccagacca acctgaggaa agcagtgatt cttattttag
     6601 gagttaggaa tgaatacacg aaatcaattt agctgattat tttttgtttt tcaagaattc
     6661 atcgtattgt ttttgcattt cgttcaatac tttttcgtag gcaccttcag atttcaattt
     6721 ttccatcaat tctggaatag ctttatctgg gtctacagta ccagtgttga tagctgtatc
     6781 aaattgttgc attgtgttag caatagctga gatttcagat ttcacattgt cagtattgaa
     6841 gataaatcca agcgctggag attctttagc ttctgccaat tctttcttag aattttcgat
     6901 ttgttggtct gtaacgtttt cgttgatgta aaggatccag ttgttaccag tgttccatcc
     6961 acccatgtga gtgtttcctt tgtagccatc aagaacgcga acacggtttt ctttaccttc
     7021 aattttttcc cagttcttgc cttctggacc gtaaacaaga ccgttcaaga gttctggatt
     7081 cgtattcaag aggttcaaga tttccattga tttttctttg ttcttagagt tgtttgagat
     7141 gacaaagtta gcaacttgtg ttgtttggtt tttcttgatg aagttagtaa ttggtttgat
     7201 ttggatatct ttgttggcaa cacgtgaaag caagctgtta ccgtagtcag ctggtcctac
     7261 tgtttcttca cgaacgaacc aagtatcttg ttgaaggtca aaggaagtat cgcttgttgc
     7321 gacgtctttt ggaatgtagc cagcttcata gaatttgtga agagtcttca agtgttcttt
     7381 gaaacgaggc acttcgtaac ggtttacaac tttagtagta tcgccttcaa ggtcgataac
     7441 gaatggaaga ccgtttgcta ctgggtagtc aaagttatca gatgggatga aaactttacc
     7501 aatagcaaat ggtactacgt ctggagcttt ttctttaatt tgtttcaaga ctggctcaag
     7561 agtttcgtaa gaagtaacac ctgaaatatc gataccatat ttagcaagga gagttccgtt
     7621 gaaggcaaag ttttgagatg acgcaacgtt ggctgcaact ggaacagcgt aaatcttacc
     7681 atttacagta ttacccttga tgtaagctgg gtcaagtgct ttgtaaaggt ctttaccttc
     7741 ttttttgtac aattctgtca agtcagcgta agcacctttt tgagcattta caatatagtt
     7801 atctgcaaag gcaatatcat agttttcacc agatgatgtg ataactgaca ttttcttacc
     7861 atagtcaccc cagccaaggt attggatatc caatttggca ccaacttttt cttcaatgat
     7921 tttgttggca tttgctaaca attcatccaa gttgtctggt ttgtcaccga tttggtacat
     7981 tttgataaca ggtttgtcac ctgaatcagc agctttttta ctgttacctg tcaagttgcc
     8041 acaagcagca agacctgcag ccaaagcgac tacactagca gatgcaaaag catatttttt
     8101 ccagtttttc atgataaaaa ctcctttttt tatttttaaa cttataaaca atgtaatgat
     8161 cttatactca atgaaaatca aagagcaaac tagaaaacta gccgcaggct gtacttgagt
     8221 acggcaaggc gacgttgacg cggtttgaat ttgattttcg aagagtatta acttcacaca
     8281 agggaagttg ggaactgaga aatgttcttt ttcaataagc actattcttt cacaccaccg
     8341 atagtcaaac cttttacaaa gtagcgttgg aagaatggat ataaaatcgc gattggaagg
     8401 gttgcaacca caaccatggc catacgacct gtttctttcg gtagagcaac tcccagttga
     8461 ccagtcaagc cgaccgcttt ggcaatgtag tccatatttt gttggatttg catgagcaaa
     8521 tattgcaatg gatacaagtt atcactcttg atgtaaagaa gggcgttgaa ccagtcattc
     8581 cagaaaccaa gagctgtcaa aagcgtgatg gttgcgatac ctggtagtga caatggcaaa
     8641 cagatttgga agaaaatccg ggcctcactg gcaccatcga tacgagccga ttcgagaatg
     8701 gcttctggaa tggtcttctt gaagaaggaa cgcatcaaga tgatgttaaa gggggagaga
     8761 agcattggca caatcaaggc ccaaacagtg tcaccaagct gaagtacacg ggtcaccatg
     8821 atataacctg gtaccaaacc agcgttgaac aacatactga gaaggacgaa gatggtaaaa
     8881 aatctgcgat acttaaaggt tgtccgtgaa atagcgtagg cataggttgt tgtgataaag
     8941 acatttgtca atgtcccaac tacggttaca aagacagaga tgaagagggc ttgtaggatt
     9001 ttatccttaa actgtgccaa aaactcaaaa ccgtctaagc caaattggga tgggaagaag
     9061 ctatagccgt attggaggag gcttttctcg tctgtcactg aaataatgat aacgaataca
     9121 aaaggtagga tacaagagag ggcaatcaaa cccgaaatga tactgaagaa gatatctgct
     9181 ttcttactga aggagtgaat gccgacatta tcaatttttt cttttttaat tttctttttt
     9241 gccatattct cctcctttct agaacaaagc tgagtttgga tcgactcgtc ttgcaagcaa
     9301 gtttgatagg ataaccagaa tcaaaccaac aacggattgg taaagaccgg ctgctgcagc
     9361 cataccgata tctgctgtct gagtcaaacc attaaagaca tatacgtcca aaacgttggt
     9421 tacattgtaa agctgaccag cattgtgtgg gatttgatag aagagaccga agtctgcgcg
     9481 gaagatattt ccgactgcaa ggatggtcaa tacagttaca agcggagtca actgaggaat
     9541 ggttacgttg cgaatacgtt gccacttgct agctccgtcc actgtcgctg cttcgtagta
     9601 ggttggatca attcccatga tcgtcgcata gtacatgaca ctgctatatc caaagccttt
     9661 ccaaatacct aggaaaagta ggagataggg ccagatgccc aggtcagcgt aaaaattgac
     9721 ttctttgaga ccaagacttt ccaatagatg attgaacacc cctttatcaa tatttaggaa
     9781 ggcatctgta aagaaactga tgataaccca agacaagaag taagggaaca acatagaagt
     9841 ttggaaaatc ttcaccattc tcttagaacg gagctcgctg aggataatgg caatccctac
     9901 agatacaact aaacctagaa agataaagcc aagattgtag aggacagtat ttcgtgtgat
     9961 aataaaggcg tctcttgaac taaataagaa tctgaaatta tcgagtccga cccatttact
    10021 atttatgata ctatctatga aaccattact ggtcatgtgg tagtctttga aggcaaccac
    10081 gttcccaaat actggaatgt aaaagaatag aatcaaccag agtgcccctg gcaaaaccat
    10141 caagagaaag atccagttgt ctctcaatgt ttttgaaaac tttttcataa tttcctccct
    10201 ttttattttg atatccatct aaaaattctt ttttagactt ttgataacga ttacattatt
    10261 agtatactcc tatttgcagg ttaggttaaa ctcctaatta tagaaaaaac tccacaaatt
    10321 atgtagcaga tttaaaactt tatcaccact atcaaacaaa tgtcctaaat caattgttta
    10381 ttttatctct attagcccag tgatggcgtc actctgttat aagtatccaa caacggggta
    10441 tactgaaaaa tctccagact agggaactca gcgatagttc ctaatctgga gatttttaat
    10501 atgttattag gcgtttgctt tcaacttagc aataacctct ttaagattat caatcttagt
    10561 tgctgactgg ctttccttaa tggactctag ggaagcaatg gcatctttga ctgtttgcaa
    10621 gatatcacgt aaaccttgct ctatcaaact atcatctgca aaagctttct tagcctctgc
    10681 caaaaccaga ggtgctgaat ctgtggtagg attcgataca cctgtcaatg atctcaaaag
    10741 attttctaag gtttgagtct gcttactaat actagactaa aatcaaaaag cattatataa
    10801 cagtgatatg aaatcaacta aagaagaaat ccaaaccatc aaaacacttt taaaagactc
    10861 tcgtacagct aaatatcata aacgccttca aatcgttcta tagtaaaatg aaacaagaac
    10921 aggacaaatc gatttctaac aatgt
//
LOCUS       DAVHSO010000073        10930 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.074, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000073 DAVHSO010000000
VERSION     DAVHSO010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10930)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10930)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10930
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.074"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..1084
                     /locus_tag="VVR18_001942"
                     /pseudo
     CDS             1..1084
                     /locus_tag="VVR18_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
     gene            complement(1121..2680)
                     /locus_tag="VVR18_001943"
     CDS             complement(1121..2680)
                     /locus_tag="VVR18_001943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU6033412.1"
                     /translation="MHYEHSRKGKHMIKINHLTITQNKDLRDLVSDLTMTIQDGEKVA
                     IIGEEGNGKSTLLKTLMGEDLSDFTIKGDIQSDYQSLAYIPQKVPEDLKKKTLHDYFF
                     LDSIDLDYSILYRLAEELHFDSNRFASDQEIGNLSGGEALKIQLIHELAKPFEILFLD
                     EPSNDLDLETVDWLKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLV
                     EHLDYDSYSEQRKANFAKQSQQAANNQRAYDKTMEKHRRVKQNVETALRATKDSTAGR
                     LLAKKMKTVLSQEKRYEKTAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLEKENLS
                     IDDRVLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKLKQLLNDKREISLGFMPQDYHK
                     KLQLDLSPIAYLSKTGEKEELQKIQSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDL
                     VLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVSHDRRFLKEVCSIIYRMTE
                     HGLKLVNLEDL"
     gene            complement(2920..3237)
                     /locus_tag="VVR18_001944"
     CDS             complement(2920..3237)
                     /locus_tag="VVR18_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HEU6033413.1"
                     /translation="MEDKKLIQLLSKLNKSYQNCKQGTADDIRLQELLNTTMQELKKT
                     EKLNNSILIDLEKFYQPTSPLIGLGSLKLNNQARTAWRNYDKIHYEHVKHVLSLYGPV
                     FGF"
     gene            3407..3949
                     /locus_tag="VVR18_001945"
     CDS             3407..3949
                     /locus_tag="VVR18_001945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HEU6033414.1"
                     /translation="MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVG
                     KVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVESYPVTEVFMEGATNHLNQEILDDD
                     LVLPIENGALDLAESVSDNILLNIPIKVLTAEEEAGQGFVSGNDWQIMTEEEYQAQQA
                     VKKEENSPFAGLQGLFDGDE"
     gene            3949..4578
                     /gene="nth"
                     /locus_tag="VVR18_001946"
     CDS             3949..4578
                     /gene="nth"
                     /locus_tag="VVR18_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HEU6033415.1"
                     /translation="MVLSKKRARKVLEEIIALFPDAKPSLDFTNHFELLVAVMLSAQT
                     TDAAVNKATPGLFVAFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDF
                     DGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPL
                     EVEKRVMDILPPEQWLAAHQAMIYFGRAICHPKNPECDQYPQLYDFSNL"
     gene            4789..5310
                     /gene="pyrR"
                     /locus_tag="VVR18_001947"
     CDS             4789..5310
                     /gene="pyrR"
                     /locus_tag="VVR18_001947"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HEU6033416.1"
                     /translation="MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVF
                     IAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYT
                     GRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTE
                     LDDQDRVLITEEA"
     gene            5329..6252
                     /locus_tag="VVR18_001948"
     CDS             5329..6252
                     /locus_tag="VVR18_001948"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase catalytic
                     subunit"
                     /protein_id="HEU6033417.1"
                     /translation="MSENQQALNHVVSMEDLTVDQVMKLIKRGIEFKNGAQLPYEDHP
                     IVSNLFFEDSTRTHKSFEVAEIKLGLERLDFDVKTSSVNKGETLYDTILTLSALGVDV
                     CVIRHPEVDYYRELIASPTITTSIINGGDGSGQHPSQSLLDLMTIYEEFGHFEGLKVA
                     IAGDLDHSRVAKSNMQILKRLGAELFFAGPEEWRSQEFADYGKFVTIDEIIDQVDVMM
                     FLRVQHERHDSGAVFSKEDYHAQHGLTQERYDRLKETAILMHPAPINRDVEIADHLVE
                     APKSRIVQQMTNGVFVRMAILESVLASRNAN"
     gene            6302..7381
                     /gene="carA"
                     /locus_tag="VVR18_001949"
     CDS             6302..7381
                     /gene="carA"
                     /locus_tag="VVR18_001949"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HEU6033418.1"
                     /translation="MTKRILVLEDGTVFEGKAFGADIDVTGEIVFNTGMTGYQESITD
                     QSYNGQILTFTYPLVGNYGINRDDYESIIPTCKGVVVFEEARRASNWRNQMTLDEFLK
                     AKKIPGISGIDTRALTKIIRKHGTMRATLTHVGDSMDHVTDQLQATVLPTDNIKQVST
                     KTSYPAPGVGLSVVLVDFGLKHSILRELSKRNCNVTVVPYSTTAEEILHLNPDGVMLS
                     NGPGNPEDVPQALDMIRGVQGKIPIFGICMGHQLFAMANGAKTYKMKFGHRGFNHAVR
                     EIATGRVDFTSQNHGYAVSREDLPEHLIITHEEINDKSVEGVRHRYQPAFSVQYHPDA
                     APGPHDASYLFDEFIEMMEVFKQSN"
     gene            7693..10869
                     /gene="carB"
                     /locus_tag="VVR18_001950"
     CDS             7693..10869
                     /gene="carB"
                     /locus_tag="VVR18_001950"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HEU6033419.1"
                     /translation="MPKRTDIQKIMVIGSGPIIIGQAAEFDYAGTQACLSLKEEGYEV
                     VLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKEGPDALLPTLGGQTGLNMAMEL
                     SKNGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAVAFAA
                     TIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLSPVTQCLIERSIAGFKEIEY
                     EVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALK
                     IEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEV
                     INPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMKATGEVMAIGRNIEES
                     LLKACRSLEIGVHHNEIPELAAVSDDALIEKVVKAQDDRLFYVSEAIRRGYTPEEIAE
                     LTKIDIFYLDKLLHIFEIEQELGAHPQDLEVLKTAKLNGFSDRKIAELWGTTDDQVRQ
                     LRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIGQ
                     GVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDL
                     EQPKGVIVQFGGQTAINLAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQP
                     PGQTATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYMRTAVKASPDH
                     PVLVDSYIVGQECEVDAISDGKDVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQE
                     TIADYTKRLAIGLHCLGMMNIQFVIKDEKVYVIEVNPRASRTVPFLSKVTNIPMAQVA
                     TKLILGQSLSELGYQNGLYPESTRVHIKAPVFSFTKLAKVDSLLGPEMKSTGEVMGSD
                     ATLEKALYKAFEASYLHLPTFGNVVFTIADDAKEEALNLARRFQNIGYGILATEGTAA
                     FFASHGLQAQPVGKIGDDDKDIPSFVRKGRIQAIINTVGTKRTADEDGEQIRRSAIEH
                     GVPLFTALDTANAMLKVLESRSFVTEAI"
BASE COUNT         3173 a         2194 c         2357 g         3206 t
ORIGIN      
        1 ttagaaagcg tcgtttcaag tgctatcatt gttctaaaat gatggttgct gaaacttcta
       61 tcgtcaagaa gaatcatcaa atccctcgta tcatcaacca aaagattgct caaaagttaa
      121 ttgaaaagat ttctatgacc gatattgccc atcagctttc catctcaact tcaactgtca
      181 ttcgaaagct caatgacttt cactttgagc atgatttttc tcggcttcca aagattatgt
      241 cttgggatga gtataccttc actaagggaa agatgagttt cattgcgcaa gattttgata
      301 atcttaatat tatcactgtt cttgaaggca gaacacaagc tgtcattcga aatcactttc
      361 ttcgctacga tagagctgtc cgatgtcgcg tcaaaattat tactatggat atgtttagcc
      421 cttactatga cttggataaa cagcttcgct ttcaaatttc taggctcagg ctgaaacagt
      481 ctcccagact gtttcactcc cgaatgctaa aatcgttctt gatcgctttc acattgtaca
      541 acatcttagc cgtgctatga gtcgtgtgcg tgttcaaatt atgaatcaat ttcatcgaaa
      601 atcccatgaa tacaaggcta tcaagcgcta ctggaaactc attcaacagg atagccgtaa
      661 actgagtgat aagcgatttt atcgtcctac ttttcgtatg cacttaacca ataaagagat
      721 tttaaacaag cttttgagct attcggaaga cttgaaacac cactatcagc actatcagct
      781 cttgcttttt cacttccaga ataaggaacc agagaaattt ttcggactta ttgaggacaa
      841 tcttaagcag gttcatccta tttttcagac tgtctttaaa acatttctaa aggacaaaga
      901 gaaaatcgtc aacgcccttc aactacccta ttctaacgcc aaactggaag cgaccaataa
      961 tctcatcaaa cttatcaagc gcaatgcctt tggttttcga aactttgaaa acttcaaaaa
     1021 acggattttt atcgctctga atatcaaaaa agaaaggaca aaatttgtcc tttctcgagc
     1081 ttagcttttt ttcaacccac tacagttgac aaagagccat ttataaatct tctaaattaa
     1141 ctagcttcaa accgtgttct gtcatgcgat agatgatcga gcagacttct tttaagaaac
     1201 gacggtcatg cgaaacagtg atgagaccgc ctggataggt tgcaaagagt tttctgattt
     1261 ggggttgaga agtgggagaa aagtttcgtg tgggttcatc cagcaggaga aagtttggtt
     1321 tgcgcaggac taaatccaaa agcaggagtt ttccctgttg tccgccagat aaggagcgaa
     1381 tttgatgctg catttctgga taactgaaat tgagactagc taggtgagat tggattttct
     1441 gtagttcctc tttttcccca gttttgctga ggtaggctat tggtgataaa tccaattgca
     1501 gttttttgtg gtaatcttgt ggcataaaac caagggaaat ctctctttta tcattcagaa
     1561 gttgctttaa tttggctaat agagttgatt tcccaacacc atttggcccg ataataccga
     1621 ttttttcttg cccacggaca gttagttgta gtttttgaac caaaactcgg tcgtcaatgg
     1681 acaaattttc tttttccagt tggactaaga ctttagaagc tggtaatggt tggatgtctg
     1741 aaaagaaaag ttggatttgt tcctcttcaa gtggcttttg agtcatggac tgagctgtct
     1801 tttcgtagcg tttttcttgt gagaggacag ttttcatctt tttagccaat aggcgaccgg
     1861 cagtactatc tttggtagct cgaagcgcag tttctacatt ttgcttgact ctccgatgtt
     1921 tttccatggt tttatcgtag gctctttggt tgttagcagc ttgctgactt tgtttggcaa
     1981 aattagcctt tctctgctca ctatagctat catagtctaa atgctctact agcgtttccg
     2041 cttctttacg gtgtttgacc agtcgcaagt gaacaatagt gtctgccgtt tcagaaagaa
     2101 agtcttcatc atgggaaatg aaaataacgg tttgcctggt cttttgaatc tggcctttta
     2161 gccaatcaac tgtctcaagg tctaggtcat ttgaaggttc atctaaaaat agaatctcaa
     2221 agggtttggc taactcatgg ataagctgaa ttttcaaagc ttcgccccct gatagattgc
     2281 caatctcttg gtcacttgcg aaacgattgc tatcaaaatg caattcctcc gccaaacgat
     2341 agaggatact gtagtctaaa tcaatagaat ctaaaaagaa gtagtcgtgt aaagttttct
     2401 tttttaggtc ctcagggact ttttgaggaa tgtaggccag tgactgataa tcagactgga
     2461 tgtctccctt gatagtgaaa tcagacaaat cttcccccat taaagtttta agtaaggttg
     2521 atttaccatt tccttcttcg ccaataatag ctaccttttc cccgtcttgg atggtcatgg
     2581 ttaggtcaga tacaagatct cgtaaatctt tgttttgtgt gatggttaga tgattgattt
     2641 ttatcatatg ttttcccttt ctagaatgtt catagtgcat aacaaaaaag ctctacttta
     2701 cctagtagag cccaaagtct atgtcaaaaa aactctatta acatgccaga aaaagagcat
     2761 aaaagagcac acaaaaagag acaaaaacaa gatctactaa ataaaggttc tttatttgat
     2821 agacttagtt gttcatgtct cccttacctc cgagtattag tatctttata ctataccttt
     2881 aaggaaattt tgtcaacaga aaactggaaa ttctatgctc taaaatccaa aaacaggtcc
     2941 atagagactt agtacgtgtt tgacatgctc gtaatggatt ttgtcatagt ttcgccaagc
     3001 agtgcgtgct tgattgttta gttttaggct acccagtcca atcagaggac tggtgggttg
     3061 gtaaaatttc tcaagatcaa ttaagatact gttgttcaac ttttccgttt ttttgagctc
     3121 ttgcatagta gtgtttagca gctcttgtag tcgaatatca tctgccgtac cctgtttaca
     3181 gttttggtag cttttattta acttggatag gagttgaatg agtttcttgt cttccatgtg
     3241 agcatcctcc ttgatctgat gtactctttc cctatagtat agcactaaaa aacaaaacta
     3301 tcatggtaaa tatgttaaaa ttttgaattt taattacaaa gtttggtgtg ctgatttgta
     3361 gccttttcat ggtataatca agagagtaaa tctttatgga ggaagtatga aattaaatat
     3421 tcaagaaatt cgtaagcagt ctgaaggttt gaactttgaa caaacgttag atttagttga
     3481 tgacctgcgt gcacgtaatc aagaaatttt agatgtaaaa gatatccttg cagttgggaa
     3541 agtacaatat gaagaccgta tgtatttctt agattatcaa ctatcttata ccattgttct
     3601 tgcttcgagt cgcagtatgg agccagttga gttagttgaa tcttatccag tcacggaagt
     3661 tttcatggaa ggcgcaacta accatctaaa tcaagaaatt ttagatgatg acttggtctt
     3721 gcccatcgaa aatggggcgc ttgaccttgc tgagagtgta tcagacaata tcctgctaaa
     3781 cattcctatc aaggtcttga cggctgaaga agaagctggt caaggatttg tctcaggaaa
     3841 tgactggcaa atcatgacag aggaagaata ccaagctcaa caagcagtaa agaaagaaga
     3901 aaacagtcct tttgctggct tacaaggact atttgacgga gatgaataat ggtcttgtca
     3961 aaaaaacgag cacgaaaggt gctagaagaa atcattgccc tcttcccaga tgccaagcct
     4021 agtcttgatt ttaccaatca ttttgaactc ctggttgcgg tcatgttatc agcccagacg
     4081 acagatgcag cggtaaataa ggccacacca ggtctctttg ttgcctttcc aacaccccaa
     4141 gctatgtctg tagcgacaga gagtgagatt gcttcacata tttctcgctt gggattgtat
     4201 cggaataaag ctaaattcct taaaaaatgt gcccaacagt tactagacga ttttgatggt
     4261 caagtccctc agacacgtga agaattggag agtttggcag gtgttggtcg caagacagcc
     4321 aatgttgtca tgagtgtagg atttgggatt ccagcctttg cagtggatac tcatgtggag
     4381 cgtatttgca aacaccacga tattgtcaaa aaatcagcga cgccacttga ggtggaaaag
     4441 cgggtcatgg atatcttgcc gcctgagcag tggttagctg cccatcaggc catgatttat
     4501 tttggaagag ccatttgcca tccaaaaaat ccagagtgtg accagtaccc acaattatat
     4561 gattttagca atttgtaaga tactacattg aaactttttg cttgatttta agcatgcttt
     4621 gtgctatagt aaatgataac taaatattcc tttaaacctg tcccgtgagg caggcaagga
     4681 gcgcgataaa gtagaagggt gaagtctata ctgtgtgcag tagggctcgc ttggctataa
     4741 atttcaagtc tccttgttta aggagacttt tctttttgga ggtttgtcat gaaaacaaaa
     4801 gaagttgtag acgaattgac cgtcaaacga gcgattacgc gtattactta tgagattatc
     4861 gaacgcaaca aagatttgaa taagatcgtc ttggctggta ttaaaactcg tggtgtcttt
     4921 attgcccacc gaatccaaga acgtttgaag cagttagaaa atctttcagt tcctgttgtg
     4981 gaattggata ctaaaccttt ccgtgatgat gttaaaagtg gagaagatac ttctttggtt
     5041 tctgtcgatg tgacagaccg cgaagttatc ttggtggatg atgtgctcta tacaggtcgt
     5101 accatccgtg ctgctattga taatattgtc ggtcatggtc gtcctgcgcg tgtgagttta
     5161 gcagttctag tcgatcgtgg acatagagaa ttgccaatcc gtccagatta cgttggaaaa
     5221 aatatcccaa ccagtcgttc tgaagaaatc atcgtagaga tgacagaact tgatgaccaa
     5281 gacagagttc tgattactga agaagcttag aaagttaaag gagtagccat gtcagaaaat
     5341 caacaagcat tgaaccatgt ggtgtccatg gaagacctca ctgtcgatca agtaatgaaa
     5401 ttgatcaagc gaggaattga gtttaaaaat ggagcccagc ttccctatga agaccatccg
     5461 attgtttcca atctcttctt tgaggattct acacggacac ataagtcctt tgaagtcgca
     5521 gagattaaac ttggattgga acgacttgac tttgatgtga agactagttc ggttaataag
     5581 ggtgagacac tttatgacac cattttgact ctgtctgctt taggagtgga tgtctgtgtg
     5641 attcgccatc cagaggtcga ctactataga gaattgattg ctagtccaac gattacgact
     5701 tccatcatca atggtggaga cggttcgggt caacacccta gccagagctt gcttgatttg
     5761 atgaccattt atgaggaatt tggccacttt gagggtctta aagttgctat tgcaggtgac
     5821 ttggaccact cacgcgttgc caaatccaat atgcagattt tgaaacgctt gggagctgaa
     5881 ctctttttcg ctggacctga ggaatggaga agtcaagagt ttgcagacta tggaaagttt
     5941 gtaaccattg atgaaatcat tgatcaggtt gatgtcatga tgtttctccg tgtgcaacac
     6001 gaacgccatg atagtggagc tgtattttca aaagaagact accatgccca acatggcttg
     6061 actcaagaac gttacgatcg tttgaaagaa acagcaatcc tcatgcaccc agctccaatc
     6121 aatcgtgatg tagaaatagc agaccacttg gttgaagcac caaaatcacg gattgtccaa
     6181 caaatgacca atggtgtctt tgttcgaatg gcaatcttag aatccgtact agcgagtaga
     6241 aacgccaact aaaacacaag acgttaaaag acaccagtga gcgtccacga gaggtgaaaa
     6301 tatgacaaaa agaattctag tattagaaga tggcacagtt tttgaaggca aggccttcgg
     6361 agcagatatt gatgtaacag gcgaaatcgt ctttaataca gggatgaccg gctaccaaga
     6421 atccattaca gaccagtctt ataatggaca aatcttgacc tttacttatc ctttggtagg
     6481 aaattatggt attaatcgtg atgattatga atccattatt ccaacttgta agggagtcgt
     6541 tgtttttgaa gaagcgcgta gagctagcaa ctggcgcaac caaatgacct tggatgaatt
     6601 tttgaaagcc aagaaaattc cagggatttc aggaattgat acgcgtgctc ttaccaagat
     6661 tatccgtaag catggtacta tgcgtgcaac cttgacccat gttggggaca gtatggacca
     6721 tgtgacggac cagctccaag caacagtttt accgacagac aatatcaaac aggtttctac
     6781 taaaacgtct tatccagctc caggagttgg tttgagcgtg gtgctagtgg actttggtct
     6841 caagcactca atcctacgtg aactttctaa acgcaactgt aacgtgacag ttgttcctta
     6901 ttcgacaacg gctgaagaaa ttctccatct caatcctgat ggagttatgt tgtcaaatgg
     6961 tccaggtaac ccagaagacg ttccacaagc actcgacatg attcgcggtg tacaaggaaa
     7021 aattccaatc tttggtattt gtatgggaca ccaactcttt gcaatggcaa acggggctaa
     7081 gacctataag atgaagtttg gccaccgtgg attcaaccat gcggtacgtg aaatcgcaac
     7141 aggacgagta gacttcacca gccagaacca tggttatgca gtcagccgcg aggatttgcc
     7201 agagcacttg attattaccc acgaagaaat caatgacaag tcagtggaag gtgtgcgcca
     7261 cagataccaa cctgctttct ctgttcaata ccacccagat gcagctcctg ggccacacga
     7321 cgctagctac ctatttgacg agtttatcga gatgatggaa gtttttaaac aatcaaacta
     7381 agaacgagta aaagctcgtc ggagaattta tgtaactgaa cacggacgga aagctcagaa
     7441 tgtagagaaa ccaacttgga ttgtcaatcc ttccttgatt tcctaaaatt caatcgcttt
     7501 ctattcgtcc tttgtatctt atttaatgtc gccctgagag gcgacgaata gaaaggagaa
     7561 gatacattgt tcgcggaagt gaacacgccc taagaactgt gtgaaaaaga taaacatcgt
     7621 cttgacgctg aaggcgtctg cgccgagttt cctattttca ctgtgttctt tacgggcttt
     7681 gtatcataaa ctatgcctaa acgtactgat attcaaaaaa ttatggtgat tggttctggt
     7741 ccgattatta ttggtcaggc tgctgagttt gactacgctg ggacccaggc ttgcttgtcg
     7801 ttgaaagagg aaggttatga ggttgttttg gttaactcaa atcctgcaac catcatgacg
     7861 gacaaggaaa ttgctgacaa ggtttacatt gaaccgatta cacttgagtt tgtgacacgt
     7921 attcttcgta aggaaggtcc agatgccttg ctaccaacac tcggtggtca gacaggtctc
     7981 aacatggcca tggaattgtc taaaaatggt atcttagatg agcttggcgt tgaacttctg
     8041 ggtaccaaat tatctgccat tgaccaagcg gaggaccgtg acctctttaa acaattgatg
     8101 gaagagcttg aacaacccat tccagaatct gaaattgtta acacagtaga agaagcagtt
     8161 gcctttgcag cgacaattgg ctacccagtc atcgttcgtc cagcctttac cctcggtggt
     8221 actggtggtg gtatgtgtgc caatgagaaa gaattgcgtg aaatcactga aaatggtttg
     8281 aaattgtcac ctgttaccca atgtttgatt gagcgttcga ttgccggttt caaggaaatt
     8341 gaatacgaag tgatgcgtga ctcagctgac aatgccttgg ttgtttgtaa catggaaaac
     8401 tttgacccag ttgggattca cacgggggat tccattgtat ttgcccctgc gcaaaccatg
     8461 tcagactatg aaaaccaaat gcttcgtgat gcgagcttga gcattattcg tgccctcaag
     8521 attgaaggtg gatgtaatgt tcagctagct cttgatccta acagcttcaa gtattatgtt
     8581 atcgaagtaa accctcgtgt atcacgttcg tcagcccttg cttctaaagc gactggatat
     8641 ccgattgcta agttggctgc caagattgca gtaggtttga ccttggatga ggttataaac
     8701 ccagttacag gttcaaccta tgccatgttt gaaccagccc ttgactacgt agttgctaag
     8761 attccacgtt tcccatttga caagtttgaa aagggtgaac gccgtctcgg tacacaaatg
     8821 aaggcgactg gagaagtcat ggcaatcggt cgtaatatcg aggaatctct tctcaaggcc
     8881 tgccgctccc ttgaaattgg ggtgcaccac aatgaaatac ctgaacttgc agcagtttct
     8941 gatgatgcct tgattgaaaa ggttgtcaaa gcccaagatg accgtctctt ctacgtatca
     9001 gaagcaattc gtcgtggcta cacacctgaa gaaattgcag agcttacaaa aattgatatc
     9061 ttctatcttg ataaactttt gcatatcttt gaaattgagc aagaattggg tgctcatcca
     9121 caagatctag aagttttgaa aacagccaaa cttaatggtt tctcagaccg taagattgct
     9181 gaactctggg gaacgactga tgatcaagtt cgccaacttc gcttggaaaa caagattgtt
     9241 ccagtttata agatggtaga cacttgtgcg gcagagttcg actccgaaac gccatatttc
     9301 tattcaacct atggttggga aaatgaatct atcagatctg ataaagaatc tgtacttgtc
     9361 ctaggttcag gtccaatccg tatcggtcaa ggggttgagt ttgactacgc aaccgttcac
     9421 tctgttaagg ctatccaggc agctggttat gaagctatca tcatgaactc aaacccagag
     9481 accgtttcaa cagacttctc tgtatcagat aagctttact ttgagccatt gacattcgaa
     9541 gatgttatga acgtcattga cttggaacaa ccaaagggag ttatcgttca gttcggtggt
     9601 caaacagcca tcaaccttgc ggagccattg gcaaaagcag gtgtgaccat ccttggtaca
     9661 caggttgctg acctagaccg tgccgaagac cgtgacctct tcgagcaagc tctcaaagaa
     9721 ttggatattc cacagccacc aggacaaaca gctaccaatg aagaagaagc agctcttgca
     9781 gctcgcaaga ttggcttccc agttcttgtc cgcccatctt atgtacttgg tggacgtgcc
     9841 atggaaatcg ttgaaaacga agaagacctt cgttcttaca tgcgaactgc tgttaaggct
     9901 agtccagacc acccagttct tgtcgactct tatatcgttg ggcaagagtg cgaagttgat
     9961 gccatttcag atggtaaaga tgtactcatt cctggtatca tggagcatat cgaacgtgct
    10021 ggtgtccact caggtgactc aatggctgtt tacccaccac aaaccttgtc gcaaaaggtt
    10081 caggagacca tcgcagacta caccaaacgc ttagcaatcg gtcttcactg ccttggaatg
    10141 atgaacatcc agtttgttat caaggatgaa aaagtctacg ttattgaggt caatccacgt
    10201 gccagccgta ctgttccatt cctatctaag gtaaccaata ttcctatggc tcaagtagcg
    10261 accaagctca ttcttggtca aagtttatca gaacttggct accaaaatgg actttaccct
    10321 gaaagcaccc gtgttcatat caaggcacct gtcttctcct ttaccaaact agctaaggta
    10381 gacagcttgc tcggtcctga aatgaagtca acaggtgaag ttatgggttc tgatgctact
    10441 ttggaaaaag ctctctataa agcctttgaa gcttcttatc tacacttgcc aacttttggt
    10501 aatgtcgtct ttaccatcgc tgatgatgcc aaagaagaag ccttgaactt ggctcgtcgt
    10561 ttccaaaaca ttggttatgg aatccttgcg acagaaggga cagcagcctt ctttgctagc
    10621 catggcttgc aagcccaacc tgttggtaag attggtgatg acgataagga tatcccaagt
    10681 tttgtacgca aaggaagaat tcaagctatc attaacacag taggaacaaa acgaactgct
    10741 gacgaagatg gtgagcaaat tcgtcgttca gccattgaac acggggtgcc cctcttcaca
    10801 gcgctagata cagctaatgc catgcttaag gtacttgaaa gtcgtagctt tgttacagaa
    10861 gcgatttaaa tagaaaaata aggtatagca gactgaattt agaacagtac acagggatac
    10921 taaaatattt
//
LOCUS       DAVHSO010000074        10712 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.075, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000074 DAVHSO010000000
VERSION     DAVHSO010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10712)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10712)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10712
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.075"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(112..861)
                     /locus_tag="VVR18_001951"
     CDS             complement(112..861)
                     /locus_tag="VVR18_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HEU6033420.1"
                     /translation="MFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRT
                     WWDPVYMAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINV
                     LKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMTLKGLISRERVDM
                     NFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWWFIRIPAL
                     ILAIILAILTIIFSFIASFIWNPDKKREELA"
     gene            994..3330
                     /locus_tag="VVR18_001952"
     CDS             994..3330
                     /locus_tag="VVR18_001952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IC family P-type ATPase"
                     /protein_id="HEU6033421.1"
                     /translation="MDKNKIMGLTQREVKERQAEGLVNDFTASASTSTWQIVKRNVFT
                     LFNALNFAIALALAFVQAWSNLVFFAVICFNAFSGIVTELRAKHMVDKLNLMTKEKVK
                     TIRDGQEVSLNPEELVLGDVIRLSAGEQIPSDALVLEGFAEVNEAMLTGESDLVQKEV
                     DSLLLSGSFLASGSVLARVHHVGADNYAAKLMLEAKTVKPINSRIMKSLDKLAGFTGK
                     IIIPFGLALLLEALLLKGLPLKSSVVNSSTALLGMLPKGIALLTITSLLTAVIKLGLK
                     KVLVQEMYSVETLARVDMLCLDKTGTITQGKMQVEAVLPLTETYGEEAVASILTSYMA
                     HSEDKNPTAQAIRQRFQGQVVYPMLSNLPFSSDRKWGAMELEGLGIVFLGAPEMLLDS
                     EVPEAREALERGSRVLVLALSQEKLDHHKPQKPSDIQALALLEILDPIREGAAETLNY
                     LRSQEVGLKIISGDNPVTVSSIAQKAGFADYHSYVDCSKITDEELIALAEETAIFGRV
                     SPHQKKLIIQTLKKAGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLLN
                     SDFNDVPEILFEGRRVVNNIAHIAPIFLIKTIYSFLLAVICIASALLGRSEWILIFPF
                     IPIQITMIDQFVEGFPPFVLTFERNIKPVEPNFLRKSMLRALPSALMVVFSVLFVKIF
                     GTSQGWSELEISTLLYYLLGSIGFLSVFRACMPFTLWRVLLIVWSVGGFLATALFPRI
                     QKLLEIATLTEQTLPVYGVMMLVFTVIFILTSRYQARK"
     gene            3859..5322
                     /locus_tag="VVR18_001953"
     CDS             3859..5322
                     /locus_tag="VVR18_001953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000087917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HEU6033422.1"
                     /translation="MSRKQEQMETLLLLLRDSKDYISAKVLGEKLNCSDKTVYRLVKV
                     INKDCPVEAFILSEKGRGFKLNPRSSLVDVDGNFTEAFDPEVRREKLLERLLLTAPKP
                     HSIYDLGEEFYVSESVVLKDRQILQESLAIYGLDLKMRQRKLFIDGDEAQIRSAILNL
                     LPMFNQLDLEQITQNKVQPLDGELAHFCLGLLITLERELGVNIPYPYNINIFSHLYIF
                     ISRNRRSTSIHVVAPSKPTIVDEKIYSVCQKIIQEIEQYFKMKVDAVEIDYLYQYVVS
                     SRLQKPFSSGKLPFSQRVLDVTHYYFSRMCMDNREIETTDPDFVDLASHISPLLRRLD
                     NRVQIKNSLLSQILLTYPNLVKELTTISKEVSLVFGFASLSLDEIGFLVLYFARFQEK
                     RARPLKTVVMCTSGVGTSELLRARLEKQFTELDIIDVVAYHQLDELINLYPDLDFIVT
                     TVALQEPASVPFVLVSVFLTEGDKQRLQAKIQEINYE"
     gene            5315..5743
                     /locus_tag="VVR18_001954"
     CDS             5315..5743
                     /locus_tag="VVR18_001954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6033423.1"
                     /translation="MNNLSLVLMDISVQNRQEAYKELANQISLLVSEDTEKIEELLYY
                     RERQGSIEVAKGVLLPHCEGNFQHHVLVITRLKSPIREWSKDIQCVDLIIGLAIAVSQ
                     DKSCIKTLMRRLADESFINQLKQLTKEELREIIYGNQRYS"
     gene            5721..6170
                     /locus_tag="VVR18_001955"
     CDS             5721..6170
                     /locus_tag="VVR18_001955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU6033424.1"
                     /translation="MEIKDILNVSLIQTDLQMQSKEEVFEALAQLLVETGYVSDRDQF
                     IEGLYQREAEGQTGIGNYIAIPHSKSSAVEKAGVVIAINHNEIPWETIDGKGVKVIVL
                     FAVGDDTEAAREHLKTLSLFARKLGNDEVVAKLVRAQTSDDVIAAFC"
     gene            6198..6509
                     /locus_tag="VVR18_001956"
     CDS             6198..6509
                     /locus_tag="VVR18_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HEU6033425.1"
                     /translation="MKIVGVAACTVGIAHTYIAQEKLENAAKVAGHVIHVETQGTIGV
                     ENELSQEQIDAADVVILAVDVKISGMERFEGKKIIKVPTEVAVKSPNKLIAKAVEIVT
                     K"
     gene            6535..7620
                     /locus_tag="VVR18_001957"
     CDS             6535..7620
                     /locus_tag="VVR18_001957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HEU6033426.1"
                     /translation="MLKHLNLKGHLLTAISYMIPIVCGAGFLVAIGLAMGGGVPDALV
                     AGKFTIWDALATMGGKALGLLPVVIATGLSYSIAGKPGIAPGFVVGLIANSVGSGFIG
                     GILGGYIAGFLVQAIIKKVKVPNWIKGLMPTLIIPFVASLVSSLIMIYIIGAPIAAFT
                     NWLTSLLQSLGSASNGLMGAVIGVLSAVDFGGPLNKTVYAFVLTLQAEGVKEPLTALQ
                     LVNTATPVGFGLAYFIAKLLKKNIYTQEEIETLKSAVPMGIVNIVEGVIPIVMNNLVP
                     GLIATGIGGAVGGAVSLTMGADSAVPFGGVLMLPTMTRPVAGICALLANIVVTGLVYA
                     ILKKPIKHTEPVMTVEEEIDLSDIEIL"
     gene            7631..8326
                     /locus_tag="VVR18_001958"
     CDS             7631..8326
                     /locus_tag="VVR18_001958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000086495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HEU6033427.1"
                     /translation="MSRIEFSPSLMTMDLDKFKEQITFLNDKVASYHIDIMDGHFVPN
                     ITLSPWFIQEVQKISDTPLSVHLMVTDPTFWVDQVLDLQCEYICIHAEVLNGLAFRLI
                     DKIHDAGLKAGVVLNPETPVSTIFPYIDLLDKVTIMTVDPGFAGQRFLESTLYKIQEL
                     RQLRVQNGYHYIIEMDGSSSRKTFKQIDVAGPDIYVIGRSGLFGLDDDIAKAWDICSR
                     DYEEMTGKTMPIK"
     gene            8363..10333
                     /gene="tkt"
                     /locus_tag="VVR18_001959"
     CDS             8363..10333
                     /gene="tkt"
                     /locus_tag="VVR18_001959"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEU6033428.1"
                     /translation="MSLQSVNAIRFLGVDAINKSNSGHPGIVMGAAPMAYSLFTKHLR
                     ITPEQPNWINRDRFILSAGHGSMLLYALLHLTGYNDVSMDEIKNFRQWGSKTPGHPEV
                     THTSGVDATSGPLGQGISTAVGFAQAERFLAAKYNKDGFPIFDHYTYVIAGDGDFMEG
                     VSAEAASYAGHQALDKLIVLYDSNDICLDGETKDTFSENVRARYDAYGWHTVLVEDGT
                     DLAAISTAIETAKFSGKPSLIEVKTVIGYGSPNKSGTNAVHGAPLGAEETGATRKFLG
                     WDYDPFEVPEEVYSDFKTNVADRGQEAYDAWASLVSDYKVAYPEVASEIDAIVAGKSP
                     VTITEKDFPVYENGFSQATRNSSQDAINTAAAVLPTFLGGSADLAHSNMTYIKADGLQ
                     DKYNPLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYIKAAIRLSAIQEL
                     PVTYVFTHDSIAVGEDGPTHEPVEHLAGLRSMPNLTVIRPADARETQAAWHHALTSTT
                     TPTVIVLTRQNLVVEEGTDFGKVAKGAYVVYDTPGFDTIIIATGSEVNLAIKAAKELV
                     LQGGKVRVVSMPSTELFDAQDATYKEDILPSKTRRRVAIEMAATQSWYKYVGLDGAVI
                     GIDIFGASAPAQTVIDNYGFTVENIVAQVKSL"
BASE COUNT         3078 a         1910 c         2418 g         3306 t
ORIGIN      
        1 aggacagtca aatcgatttc taaaaatgtt ttagaagtag aggtgtacta ttctagttcc
       61 aatctactat ataaatgaaa accttagctg tttggccaag gttcatttct tctatgcaag
      121 ttcttctctt ttcttatctg ggttccagat gaagcttgcg ataaagctaa agatgatggt
      181 taggatagcg aggataatag caaggatgag ggcagggatg cggataaacc accagagtgg
      241 atttggtttt ttatcattgt gccattgttt cgtttcttcg tccagacgtt ggaattctgt
      301 ttgaatacga ttggcgactg tttcaatgcc ttcatcattc attttcttga tatctgagat
      361 atcgattgga tttccaaagt tcatatcgac acgttcacgg ctaatcaagc ccttcaaagt
      421 catgggaccg gtgtaggtaa ccggcatgat acggaccttg gccattttgg caatcagtgc
      481 tgcgcccccc ttgacatcgt ttgagtggcg gctaccactt ggaaacatga tgagagagcg
      541 gtcacttttt ttgagaacgt tgataggata tttgatggct gaggcgctgg gattttcacg
      601 gtcgatggga aaggcgccac acatacgaat ccaccaacca aagatacggt tggtaaagag
      661 ttcttttttt gccataaaga tgaactgttt tggcttggtc gcaaaggcca tataaacagg
      721 atcccaccag gtacggtgag gcgcaactaa aatataattt tcatcttgat taggaatttt
      781 atcagtatta tgatagtgag cattgccatt gatggaccat aagagcaaca caactaatcc
      841 acgcaaataa gtataaaaca tgcgatctcc ttcgattgtt ttcttgttat tattatacct
      901 tatcaaagga gggctggcaa acttttccct tgactagatg catatttagg atgaaattag
      961 aattctgtta aaaaaaatga tataatagaa tttatggata aaaataagat tatgggatta
     1021 acccaaagag aagtcaagga aagacaggct gagggtttgg tcaatgactt taccgcatca
     1081 gccagtacca gcacttggca aatcgttaaa cgaaatgtct ttaccctttt taacgctttg
     1141 aactttgcca ttgctttggc ccttgccttt gtgcaggctt ggagcaatct ggtcttcttt
     1201 gctgttatct gctttaacgc tttttctggg attgtgaccg agctacgagc caaacacatg
     1261 gtggacaagc tcaatctcat gaccaaggaa aaggtcaaaa ccatccgtga tggtcaggaa
     1321 gtttctctta atcctgaaga attagtgcta ggagatgtca ttcgtttgtc tgcaggagag
     1381 cagattccta gtgatgcctt ggttttggaa ggctttgcgg aagtcaatga agccatgtta
     1441 acgggagaaa gtgatttggt gcaaaaggaa gttgacagct tacttttgtc aggaagtttc
     1501 ttggctagtg ggtcagtttt agctcgtgtc catcatgtag gtgcagacaa ctatgccgcc
     1561 aaacttatgc tggaagccaa gaccgttaaa cccatcaact cacgtatcat gaaatcgctg
     1621 gacaagctag caggttttac tgggaagatt atcattccct ttggtctggc tctcttgctg
     1681 gaagccttgc ttttaaaagg cctgcctctc aagtcatctg ttgtaaattc gtcgacagcc
     1741 cttttgggaa tgttgcctaa gggaattgcc cttttgacca ttacttcgct cttgactgca
     1801 gtgattaagc ttggcttgaa aaaggtcttg gtgcaggaga tgtactctgt tgagaccttg
     1861 gcgcgcgtgg atatgctctg tctggacaag acgggtacca tcacccaagg aaagatgcag
     1921 gtggaggctg ttcttccact gacggaaact tatggtgaag aggctgttgc cagcatcctg
     1981 accagctata tggcccatag tgaggataaa aatccaacag ctcaagccat tcgccagaga
     2041 ttccaaggtc aagtagtcta tcctatgctc tctaatcttc ccttctccag cgaccgcaag
     2101 tggggagcca tggagttaga aggtttggga atagttttct taggggcacc tgagatgttg
     2161 ctggattctg aggtcccaga agccagagag gccttggaga gaggttcacg tgtcttggtc
     2221 ttagctctca gtcaggagaa attagaccat cacaaaccac agaaaccatc tgatattcag
     2281 gctctagcct tgctggaaat cttggatcct attcgagagg gagcggcaga gacgctgaac
     2341 tatctccgtt ctcaggaagt ggggctcaag attatctctg gtgacaatcc agttacggta
     2401 tccagcattg cccagaaggc tggttttgcg gactatcaca gctatgtcga ttgttcaaaa
     2461 atcacggatg aggaattgat tgctctggcg gaggagacag cgattttcgg acgtgtttcc
     2521 cctcatcaaa agaaactcat tatccaaacg ctgaaaaaag cgggtcatac aacagctatg
     2581 actggggatg gagttaatga tatcctggct cttcgtgagg cggattgttc tatcgtaatg
     2641 gcggagggag acccggcaac ccgtcagatt gccaacctgg ttctcttgaa ctcagacttt
     2701 aatgatgttc ctgagattct ttttgaaggt cgtcgtgtgg tcaataacat tgcccacatc
     2761 gctccgattt tcttgataaa gaccatctac tcattcttgc tcgcagttat ctgtattgcc
     2821 agtgctttac taggtcggtc agagtggatt ttgattttcc ccttcattcc gatccagatt
     2881 accatgattg accagtttgt ggaaggtttc ccaccatttg ttctgacttt tgagcgaaat
     2941 atcaaacctg ttgagccaaa tttcctcaga aaatccatgc ttcgtgccct accaagtgcc
     3001 ctcatggtcg tgtttagcgt tctttttgtg aaaatctttg gaacgagtca aggttggtct
     3061 gagttagaaa tctcaactct cctctattat ctcttggggt caattggttt cttatccgta
     3121 tttagagcct gcatgccatt cactctatgg cgagtcctct tgattgtctg gtcagtagga
     3181 ggcttcctag ccacagctct cttcccaaga atccaaaaac tgcttgaaat tgcaaccttg
     3241 acagaacaaa cgttgcctgt ttatggtgtc atgatgttgg tctttacagt gattttcatc
     3301 ctgactagtc gctatcaagc tagaaaataa agaaagactg caatctgtgg attgcagttt
     3361 tttatacgat ggatctatcg tagatctgat gtgcaaggcc tacgtgtcta ttatctatcg
     3421 gtgaacccaa gagtgattct caagcctgct tggattgagg taatagattc aaatatctgt
     3481 agttagacta tttgaagttt gatgtaagaa agagaaagcg acagattgaa gtaattttaa
     3541 ctctcttcta ttgctagaac aaatggtcgg ataggttggt agtttgaaaa tgaagatgca
     3601 atctattgtt aaatggaaca tagtgttatt tattagaaaa tcgtttggtt tatttattat
     3661 caaatacgaa aagcaactta aatatttcaa ctaaaataga tgttatgaag aaaaggtaaa
     3721 atgattttgg tatagtgagg ttctgttcta tttgatatca tatttttgat aaaaacaaaa
     3781 atgtccattg caaaggacaa aatgcgaagt atattatttt ttgaaagcga tataatggaa
     3841 tcataaagga ggtgtatcgt gtctagaaaa caagaacaaa tggaaacgtt gttgctcctt
     3901 ttgcgagata gtaaggatta tatatctgct aaagtattgg gagaaaaatt aaattgctct
     3961 gataaaacgg tttatcgcct tgtcaaggta atcaacaaag attgtccggt agaagcattc
     4021 attttatctg aaaaaggcag aggtttcaaa ttgaatccaa gaagttccct cgtggacgtt
     4081 gatgggaatt ttacagaggc ttttgatcct gaagtaaggc gtgaaaaatt actagaacgt
     4141 ctcttgttga ctgctcctaa gccacattct atttatgatt taggagagga attctacgta
     4201 agcgagtcag tagtactaaa agatcgtcag atattacaag agagtctagc aatttatggg
     4261 ttagatttaa aaatgagaca acgaaagctt tttattgatg gggatgaggc tcaaattcgt
     4321 tcagccattc taaatctact gccaatgttt aatcagttgg atttagagca aattacacag
     4381 aataaggttc agcctcttga cggagaactt gctcactttt gtttgggatt actgattaca
     4441 cttgagagag aattgggggt aaacattccc tatccatata atataaatat tttctctcac
     4501 ctgtatattt ttatcagtag gaatcgtcgt agtactagta ttcatgttgt agcaccttca
     4561 aaacctacta ttgttgatga gaaaatttac agtgtctgtc aaaaaattat tcaagaaatt
     4621 gaacaatatt ttaagatgaa ggttgatgca gttgagattg actatcttta tcaatacgtt
     4681 gtatcttcga gattgcaaaa accattttct tccgggaagc ttcctttttc tcagcgagtt
     4741 ttagatgtca ctcattacta ttttagccgt atgtgtatgg acaatagaga gattgaaacg
     4801 acagatcctg actttgttga cttggcgagt catatcagtc ccttactgag gagattagat
     4861 aatagagtac agattaagaa tagtctttta tcacaaattc ttttaaccta tcctaatcta
     4921 gttaaagagt taacaactat ttctaaagaa gtgagtctag tatttggttt tgcgtccttg
     4981 agtctggacg agattggttt tctagtctta tattttgcac ggtttcaaga aaagcgagca
     5041 cgtcctctaa aaacagtagt gatgtgtaca tcaggtgtcg gaacttcaga gcttttacga
     5101 gcacgattag aaaagcaatt tactgaattg gatattattg atgtagttgc ttatcatcaa
     5161 ttagatgagc tgataaatct atatccagat ttagatttca ttgtgacgac ggtagctttg
     5221 caggaaccag caagtgtccc gtttgtccta gttagtgttt ttctaaccga gggtgataaa
     5281 caacgtcttc aagcaaaaat tcaggagata aactatgaat aatctttcgc ttgtccttat
     5341 ggatatatct gttcaaaatc gtcaagaagc ctacaaagaa ttagcaaatc aaatcagcct
     5401 tcttgtttct gaagatacag aaaaaataga agagcttcta tattaccgtg agagacaggg
     5461 aagtatagag gttgctaaag gtgttcttct accacattgt gaaggaaact ttcaacatca
     5521 tgtcttagtg attactagat taaaatcacc tatcagagaa tggtcgaagg atatccagtg
     5581 tgttgacctt attatcggtt tggccattgc agtatcacag gacaagtcat gtattaaaac
     5641 attgatgaga agactagcag atgaatcatt cataaatcaa ttaaaacagt taacaaaaga
     5701 agaattacgg gagataatat atggaaatca aagatattct taatgtgagt ctgatccaga
     5761 cggatttaca gatgcagagc aaagaagagg tttttgaggc attagctcaa ctattggttg
     5821 agacgggtta tgtgtctgat agagaccaat ttatcgaagg tctgtatcag agagaggcag
     5881 aaggacagac cggtattggg aattatattg ctattcccca tagcaagagt tctgctgtgg
     5941 agaaggcggg ggtagtcata gctataaatc acaatgagat tccttgggag accattgatg
     6001 ggaaaggggt caaagtaatt gtactctttg cagttggtga tgatacagaa gctgctaggg
     6061 agcatttgaa gaccttatca ctctttgctc gaaaacttgg taatgacgaa gttgttgcca
     6121 aattagttcg ggctcagaca tctgatgatg tgattgcagc tttttgttaa taagaaaaaa
     6181 ttttggaggg tatccgtatg aaaattgttg gtgttgcagc ttgtactgtg ggaattgccc
     6241 acacttatat tgcacaggaa aaattagaga atgccgcaaa ggtagctgga catgtgattc
     6301 atgttgagac tcaggggaca ataggggtag aaaatgaatt gagtcaagag cagattgatg
     6361 cagcggatgt agttatttta gcagttgatg ttaagatttc tggtatggaa cgctttgagg
     6421 gtaaaaagat tatcaaggtt ccaacagaag tggcagtcaa atctcccaat aaactgattg
     6481 ctaaagctgt tgagattgtt acgaaataac tgaaaatatt taaggagaaa atatatgttg
     6541 aaacacttaa acttaaaagg tcacttattg acagccattt cctatatgat tccaattgtt
     6601 tgtggtgcag gattcttagt tgccattggt ttagcaatgg ggggtggtgt tcctgacgct
     6661 cttgtagcag gaaaattcac tatctgggat gctttagcaa ctatgggtgg taaagccctt
     6721 ggtctcttgc cagttgttat tgctacaggt ttgtcttact cgattgctgg taagccaggg
     6781 attgcaccag gttttgttgt tggtctaatt gccaattctg ttggttcagg gtttatcggt
     6841 ggtatcttgg gaggttatat agctggtttc ttggttcaag cgattattaa aaaggtcaaa
     6901 gtaccaaact ggattaaagg tttaatgcca accttgatta ttccttttgt agcctctttg
     6961 gtaagtagtt tgattatgat ttatattatt ggagcgccta tcgcagcctt taccaactgg
     7021 ttgacgagct tattacaaag cttgggaagt gcttcaaatg gtttgatggg ggcagttatt
     7081 ggagttctca gtgctgttga ctttggtggc ccacttaata aaacagtcta tgcgtttgtg
     7141 ttgactttac aggctgaagg tgtgaaagaa ccattgactg ctttgcaatt ggtgaatact
     7201 gctacaccag ttggatttgg attggcctat tttatcgcga aattactcaa aaaaaatatc
     7261 tatactcaag aggaaatcga aacattgaaa tcggctgttc ctatggggat tgtcaatatt
     7321 gttgaaggtg taattccgat tgttatgaat aacttggttc caggtctcat tgcaacaggt
     7381 atcggtggtg ctgttggtgg tgctgtttct ttgacaatgg gtgctgattc tgccgtgcca
     7441 tttggtggag tgcttatgtt accaaccatg actcgtccag tagctggtat ttgtgctttg
     7501 ttagccaaca ttgtagtcac aggacttgtc tacgcgattt tgaaaaaacc aataaaacat
     7561 acagaaccag ttatgactgt tgaagaagag attgatttgt cagatattga aattttgtaa
     7621 gagggtaacg atgtcaagaa ttgaattttc accatctttg atgaccatgg atttggacaa
     7681 attcaaagag cagattactt ttttgaatga taaagtagca tcttatcata tcgatattat
     7741 ggatggccat tttgttccca atattacctt gtctccttgg ttcattcaag aagttcaaaa
     7801 aattagtgac acacctttat cagttcatct gatggtcaca gacccaacct tttgggtaga
     7861 tcaagttctc gatttacaat gtgagtatat ttgtattcat gctgaagttc tgaatggtct
     7921 tgcttttcgt ttgattgata aaattcatga tgcaggtcta aaggctggtg ttgtccttaa
     7981 tcctgaaaca cctgtttcta caatctttcc ctacattgat ttacttgaca aagtaactat
     8041 tatgactgta gatccaggtt ttgcaggaca acgttttttg gagtctacct tgtataaaat
     8101 ccaagaactc cgtcagctta gagttcagaa tggttatcac tacatcattg agatggatgg
     8161 ttcttcgagt cgtaagactt tcaaacaaat tgatgtggca ggaccagata tttatgttat
     8221 aggtcgcagt ggattatttg gtttggatga cgatattgcc aaagcctggg atatctgttc
     8281 tagagattac gaagaaatga ccggaaaaac aatgccaatc aaataatggt ttgagaagaa
     8341 atttattagt taggaggaat atatgtcact acaatcagtt aacgccattc gttttcttgg
     8401 cgtagatgct attaacaaat ctaattctgg tcacccggga atcgtcatgg gtgctgcgcc
     8461 aatggcttat agcctattta caaagcacct tagaattaca cctgagcagc caaactggat
     8521 taaccgagat cgctttatct tgtctgcggg tcatggatca atgctactgt atgctctctt
     8581 gcatttaaca gggtataacg atgtatccat ggacgagatt aaaaatttcc ggcaatgggg
     8641 atctaagaca cctggtcatc ctgaagtgac gcatacgtct ggtgtggatg cgacatctgg
     8701 tccgcttggt caggggattt ctactgccgt tggtttcgcc caagcagagc gttttttagc
     8761 tgctaagtac aacaaagatg gttttcctat ttttgaccat tatacttatg ttatcgctgg
     8821 agacggtgac ttcatggaag gagtgtctgc ggaggcggct tcttatgcag gtcatcaagc
     8881 tttagataag cttatcgtcc tctacgactc caacgatatc tgcttggatg gtgagaccaa
     8941 agatactttc tctgaaaatg ttcgcgcccg ttacgatgct tatggttggc atacagttct
     9001 ggtagaagat ggaacagatt tagcagcaat ttctacagca attgagacgg ccaagttttc
     9061 tggtaagccg agtttgattg aagtgaaaac ggtaattggt tacggctcac ccaataaaag
     9121 tggtacaaat gctgttcatg gtgcaccact aggagcagaa gaaacaggag caactcgtaa
     9181 gtttttggga tgggattacg atccatttga agtaccagag gaagtatatt ctgatttcaa
     9241 gacaaatgta gcggatcgtg gtcaggaggc atacgatgct tgggctagtt tggtgtctga
     9301 ttacaaggtt gcttatcccg aagttgctag tgagattgac gctattgtag ctggaaaatc
     9361 ccctgtaacc attactgaaa aagacttccc tgtctatgag aatggcttct ctcaagcaac
     9421 tcgtaattcg tcccaagatg ctattaatac agcagcagca gttttaccaa ccttcttagg
     9481 tggatcggca gacttagctc actccaacat gacctacatc aaggcagatg gcttacaaga
     9541 taaatataat ccattaaacc gcaatattca gtttggggta cgtgaatttg ccatgggaac
     9601 aatcctcaat ggaatggctc ttcatggtgg tttacgagtt tatggcggaa ccttctttgt
     9661 tttctctgac tacatcaaag ctgctattcg gctatcagcc attcaggagt tgcctgtaac
     9721 ttatgtcttt acccatgatt caattgccgt tggtgaagat ggtccaactc atgaaccagt
     9781 tgaacatttg gcaggtttac gctcaatgcc aaacttgact gttatccgtc cagcggatgc
     9841 ccgtgaaact caagcggctt ggcatcatgc cttgaccagt accaccactc caactgtcat
     9901 tgtcttaacc cgtcaaaact tggtagttga agaagggaca gactttggta aggtcgctaa
     9961 aggagcctac gtcgtgtatg ataccccggg atttgatact attatcattg ctacaggatc
    10021 tgaggtcaat ctagctatca aagctgctaa ggaattggtt ttacaaggtg gtaaagtacg
    10081 tgtggtatct atgccctcaa ccgaactatt tgatgctcaa gatgctacct acaaggaaga
    10141 cattttacca tctaagactc gtcgtcgtgt ggccattgaa atggcagcga cccaaagttg
    10201 gtacaagtat gttggtttgg atggcgcggt catcggtatt gacatcttcg gtgcgtctgc
    10261 cccagctcag actgtgattg ataattatgg atttacggta gagaatatcg ttgctcaagt
    10321 taagtcccta tagaaaccaa ttacaatgaa gatacagctg ttgtcagact agcagatgta
    10381 gtgatagaca ctaatcagat gattggttat ttaaaaacta taatgagaat gtaataattt
    10441 atctacgaaa gttatagtag atagtataca caatagagta taccctgaaa cggttgcgaa
    10501 gtacgctaat cactttgcta ctgatctaga tagtttcttt aatcaataaa cacagcatcc
    10561 acagattgac ttaggatatt gtaagttttt tgaaagctag agagaaggtc tctaaaatta
    10621 aaaaacgcat agtataggat gttaaaatga actgacccca aaagttagac agaaaaaatc
    10681 taactttttg gggtgtttta ttatgaaatt aa
//
LOCUS       DAVHSO010000075        10671 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.076, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000075 DAVHSO010000000
VERSION     DAVHSO010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10671)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10671)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10671
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.076"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(32..1456)
                     /locus_tag="VVR18_001960"
     CDS             complement(32..1456)
                     /locus_tag="VVR18_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HEU6033429.1"
                     /translation="MTRYQNLVNGKWKSSEQEITIYSPINQEELGTVPAMTQTEADEA
                     MQAARAALPAWRALSAIERAAYLHKTAAILERDKEKIGTILAKEVAKGIKAAIGEVVR
                     TADLIRYAAEEGLRITGQAMEGGGFEAASKNKLAVVRREPVGIVLAIAPFNYPVNLSA
                     SKIAPALIAGNVVMFKPPTQGSISGLLLAKAFEEAGIPAGVFNTITGRGSEIGDYIIE
                     HKEVNFINFTGSTPIGERIGRLAGMRPIMLELGGKDAALVLEDADLEHAAKQIVAGAF
                     SYSGQRCTAIKRVIVLESVADKLATLLQEEVSKLTVGDPFDNADITPVIDNASADFIW
                     GLIEDAQEKEAQALSPIKREGNLLWPVLFDQVTKDMKVAWEEPFGPVLPIIRVASVEE
                     AIAFANESEFGLQSSVFTNDFKKAFEIAEKLEVGTVHINNKTQRGPDNFPFLGVKGSG
                     AGVQGIKYSIEAMTNVKSIVFDVK"
     gene            complement(2001..4280)
                     /gene="pulA"
                     /locus_tag="VVR18_001961"
     CDS             complement(2001..4280)
                     /gene="pulA"
                     /locus_tag="VVR18_001961"
                     /EC_number="3.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pullulanase"
                     /protein_id="HEU6033430.1"
                     /translation="MYNYPMRIHYHRKNGEYDTCSFVKSQDQRIDLLTYKEDYFGALF
                     SFEHPSSHVIESLNFVVHTGQTSKEYSIRFNHYPLLTEVWILEGDDRIYYSENPAIAS
                     PFYKNQNPFAFDKAINSASFDHHWGYQGELGCRVEDNQAHFSLWSPTATEVQVVVYES
                     AANDAPVWKTFEMKRGNSYSYNHKDNTIGVWSLDVEEDLVGKTYQYQVQFSHHQTLTR
                     DPYTIATSPDGKRSAILSHVEKQVENFEVKHGSEATWRLENPCKAVICEMHIRDLTKS
                     PTSGVDEHLRGTFLGAAQAGTVNQYGQSTAFDYIKKLGYNYVQLQPIADRHKEYDEDG
                     NVTYNWGYDPQNYNAPETSFSTNPDDPAQVIRDLKVMVQAYHDAGIGVIMDVVYNHTF
                     SVVDAPFQTTVPDYYYRMNPDGTFQNGTGVGNETASEHEMFRKYMIDSLLYWVQEYNI
                     DGFRFDLMGIHDVKTMQMIRQSLDEIDSNIILYGEGWDMGTGLAPYDKAKKDNAYQMP
                     NIGFFNDNQRDAVKGGEVYGAIKSGFVSGAATEPILAKAILGSRELGSYTHPNQVLNY
                     VEAHDNYNLHDLLATLHPDQSSEQIMRKVETATAMNLLMQGMAFMEIGQEFGRTKLVA
                     TGENGELTHDDRERAMNSYNAPDSVNQVNWNLINERQDSIEFIRQVIRLKTKTGAFSY
                     SSYDEIYHHVFVHSAIEHSGCLIYEVHGKEHLLVVVNAKSEPYQFENAGNLAMLVTNS
                     RSKEDNVLNDISLAVLSVL"
     gene            complement(4392..6350)
                     /gene="ligA"
                     /locus_tag="VVR18_001962"
     CDS             complement(4392..6350)
                     /gene="ligA"
                     /locus_tag="VVR18_001962"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HEU6033431.1"
                     /translation="MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELET
                     AYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHP
                     TYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLTEELDIT
                     VRGECYMPRASFDQVNQARQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQE
                     ASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVV
                     IKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPV
                     QLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIP
                     TNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFA
                     ANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGS
                     KASQLLLQYFHSIENLYQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETG
                     VNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVV
                     VGADAGSKLQKAQELGIQVRDEAWLESL"
     gene            complement(6443..7621)
                     /locus_tag="VVR18_001963"
     CDS             complement(6443..7621)
                     /locus_tag="VVR18_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001083019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6033432.1"
                     /translation="MNRYAVQLISRGAINKMGNMLYDYGNSVWLASMGTIGQTVLGMY
                     QISELVTSILVNPFGGVISDRFSRRKILMTADLVCGILCLAISFIRNDSWMIGALIVA
                     NIVQAIAFAFSRTANKAIITEVVEKDEIVIYNSRLELVLQVVGVSSPVLSFLVLQFAS
                     LHMTLLLDSLTFFIAFVLVAFLPKEEAKVQEKKAFTGRDIFVDIKDGLHYIWHQQEIF
                     FLLLVASSVNFFFAAFEFLLPFSNQLYGSEGAYASILTMGAIGSIIGALLASKIKANI
                     YNLLILLALTGVGVFMMGLPLPTFLSFSGNLVCELFMTIFNIHFFTQVQTKVESEFLG
                     RVLSTIFTLAILFMPIAKGFMTVLPSVHLSSFLIIGSGVIILSCISFIYVRTHFEKLI
                     "
     gene            complement(7701..8564)
                     /locus_tag="VVR18_001964"
     CDS             complement(7701..8564)
                     /locus_tag="VVR18_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012291596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HEU6033433.1"
                     /translation="MEHLGKVFREFRTSGNYSLKEAAGESCSTSQLSRFELGESDLAV
                     SRFFEILDNIHVTIENFMDKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQREQLEK
                     SKSSTTSLYFELNWILLQGLICQRDASYDMKQDDLDKVADYLFKTEEWTMYELILFGN
                     LYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLEHSSFYNANYFE
                     AYTEKIIDKGIKLYERNVFHYLKGLALYQKGQCKEGCKQMQEAMHIFDVLGLPEQVAY
                     YQEHYEKFVKS"
     gene            complement(8567..10468)
                     /locus_tag="VVR18_001965"
     CDS             complement(8567..10468)
                     /locus_tag="VVR18_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000584877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU6033434.1"
                     /translation="MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKST
                     LLKILVGEEEPTSGEINKKKDISLSYLAQDSRFESENTIYDEMLHVFDDLRRTDKQLR
                     QMELEMGEKSGDELDKLMSDYDHLSENFRQAGGFTYEADIRAILNGFKFDESMWQMKI
                     AELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDIETISWLENYLVNYSGALIIVSHD
                     RYFLDKVATITLDLTKHSLDRYVGNYSRFVELKEQKLATEAKNYEKQQKEIAALEDFV
                     NRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTFQSEKTSGNVVLTVENAAV
                     GYDGEVLSQPINLDLRKMNAVAIVGPNGIGKSTFIKSIVDQIPFIKGEKRFGANVEVG
                     YYDQTQSKLTPSNTVLDELWNDFKLTPEVEIRNRLGAFLFSGDDVKKSVGMLSGGEKA
                     RLLLAKLSMENNNFLILDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINCVAT
                     HVLELSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEASPVNDYQAQKESQK
                     EVRKLMRQIESLEAEIEELESQSQAISEQMLETNDADKLMELQAELDKISHRQEEAML
                     EWEELSDQV"
BASE COUNT         3184 a         2360 c         1906 g         3221 t
ORIGIN      
        1 aaccaggaaa acaatttcct ggttttacac gttatttcac atcaaaaaca atggatttga
       61 catttgtcat cgcttcaatg ctatatttaa ttccttgcac tccagctcca gaacctttga
      121 caccaaggaa tgggaaatta tctggaccac gctgggtttt attattaatg tggactgtac
      181 ctacttcaag tttttcagca atttcaaagg cttttttgaa atcatttgta aagactgatg
      241 attgaaggcc gaattcagat tcgttggcaa aggcaatagc ttcctctaca ctagccacac
      301 gaatgattgg taaaacagga ccaaatggct cttcccatgc cactttcata tcttttgtaa
      361 cttggtcaaa aagcactggc cagaggagat tgccctcacg tttgattggt gaaagagcct
      421 gagcctcttt ttcttgtgca tcctcaatca agccccaaat gaagtcggct gaagcattgt
      481 caataacagg tgtaatatca gcattgtcaa atggatcacc aactgttaat ttagaaactt
      541 cttcctgaag caaagtagct aatttatctg ctacactttc gagaacaatg acacgtttaa
      601 tggccgtgca acgttgtcct gagtagctaa aggctcccgc aacaatttgc ttggcagcat
      661 gttccaaatc tgcatcttct agtacaagag ctgcatcttt cccaccaagt tccaacatga
      721 taggacgcat accagctaaa cgaccaatac gttctccaat aggagttgaa cctgtaaagt
      781 tgatgaagtt gacttctttg tgctcaatga tataatcccc aatttctgaa ccacgacctg
      841 taatggtgtt gaaaacacct gccggaatcc ctgcttcttc aaatgcttta gccaacaaga
      901 gtccagaaat ggaaccttgt gttggtggct taaacatgac cacattccct gcaatcaagg
      961 caggtgcaat tttagaagca gataaattaa ctggataatt aaaaggagca atcgctagca
     1021 cgataccaac tggttcacga cggacaacag ccagtttgtt tttacttgct gcctcaaaac
     1081 caccaccttc cattgcttgt ccagtgatac ggagaccttc ctcagcagca taacgaatca
     1141 agtctgctgt acgcactact tctccaattg ctgctttaat cccttttgct acttctttgg
     1201 caaggatagt accaattttt tccttatcgc gttctaaaat agctgctgtt ttatgcaaat
     1261 aagccgcacg ttcaattgct gataaagctc gccatgctgg cagggctgca cgcgcagctt
     1321 gcatagcctc atcagcttca gtctgagtca tggctggaac tgtacccaat tcttcttgat
     1381 tgattggtga ataaatcgta atttcttgtt cagatgattt ccattttcca tttactaaat
     1441 tctgatatct tgtcaaattc ttgtcctcct gaaaatgatt aagatatatt ttaccaaatt
     1501 ttcagaaaat cacaaccctt tttgcgaaat ttttgagatt attttcacaa tcttggtttt
     1561 tcaaagtata ctcaataaaa attaaaaaaa tccactacgt caaggcgagg ctaatgtggt
     1621 ttgaagaaat tttcgaagag cgtgaatgag tatcatctat agtaaaataa aaaaactgaa
     1681 caatttggtt ggggacagcc aaaccaattt ctcacaatgt ttcagaaaca agggtgtgct
     1741 attccaattt cagcctacta taactgtcat agattgctga aacaaagtct aggtaaaagt
     1801 cttcataata aaaagacccc ctatcaagtg ttcaaaaact ttgataggag gtcttgtttt
     1861 gtgaaaatat ttatcaaatt ttctatacaa gtgagctgtt agccagattc tttctattct
     1921 ttcaatttca atgaatggat tttttaccaa tactcataac tgggaatttt tctgtctaaa
     1981 aatagcgaga tagatggtat ttataaaaca ctcaagacag ctagactaat atcatttaaa
     2041 acattatctt cttttgagcg actgttggtt accaacatag ctaaatttcc tgcattttca
     2101 aattgatagg gttctgattt agcattcaca actaccaaga ggtgttcttt gccgtgaact
     2161 tcatagataa ggcagccgct atgttcaatc gcagaatgca caaagacatg atggtaaatt
     2221 tcatcatagc tagagtaaga aaaggcacca gtttttgtct tcaatcggat gacttgacgg
     2281 ataaactcaa tactgtcttg acgctcatta atcaagttcc agttcacttg gttcacactg
     2341 tcaggagcat tatagctatt catcgcacgc tctctatcat catgggtcaa ctcaccattt
     2401 tcaccagtcg caaccagttt ggtacgacca aattcttgac cgatttccat aaaggccatc
     2461 ccctgcatga gcagattcat ggctgtggca gtttcgacct tgcgcatgat ttgctctgaa
     2521 ctttggtctg gatgaagggt tgccaataaa tcgtgaagat tgtaattgtc atgggcttct
     2581 acatagttaa gcacctgatt tggatgtgta tagcttccta attcacgact tcctaggatt
     2641 gctttagcta gaattggctc tgtcgcagca ccactgacaa aacctgactt gatagcacca
     2701 taaacttctc cccctttgac agcatcgcgc tgattgtcat taaagaaacc aatatttggc
     2761 atctggtagg cattgtcctt cttggcctta tcataagggg caagacctgt tcccatatcc
     2821 catccttctc catagaggat aatgttggag tcgatttcat ccaagctttg acgaatcatc
     2881 tgcatggtct tgacatcatg aatccccatc aagtcaaaac ggaagccgtc aatattatat
     2941 tcctgcaccc agtatagaag agaatcaatc atatacttgc gaaacatttc gtgttcactg
     3001 gctgtttcat ttccaacacc cgttccattc tggaaggtac catctggatt catacgataa
     3061 tagtaatcag ggactgttgt ttggaatggt gcatcaacaa ctgagaaggt atggttatag
     3121 actacatcca taatgactcc aatacccgca tcgtgataag cttgaaccat caccttcaaa
     3181 tcacgaatga cctgagctgg atcatctgga ttagttgaaa aactagtttc tggcgcgtta
     3241 tagttttgtg gatcataacc ccagttgtag gttacatttc catcctcatc gtattcttta
     3301 tgacggtctg caattggttg caattgaaca taattgtagc ccagcttctt gatgtaatca
     3361 aaagcagttg actggccgta ttggttaact gttccagcct gagcagcacc caagaaagtt
     3421 cctcgaagat gttcatctac acccgatgta ggtgatttag tcaaatcacg aatgtgcatt
     3481 tcacagataa ctgccttaca tggattttcc aagcgccaag tagcctccga accgtgctta
     3541 acctcgaagt tttcaacttg cttttctaca tggctcagaa tagctgaacg tttgccatca
     3601 gggctggtcg cgattgtata aggatcacgt gtcagtgttt ggtgatgaga gaattggact
     3661 tgatactgat aagtcttacc taccaaatct tcttcaacat ccaaactcca tacaccgatt
     3721 gtattgtcct tatgattata agagtagcta ttgcctcttt tcatctcaaa agtcttccaa
     3781 acgggtgcat cattagcagc tgattcataa acgacaactt gtacttctgt cgctgtaggt
     3841 gaccagaggg aaaaatgagc ctgattgtcc tctacacggc aacccaattc tccttggtaa
     3901 ccccaatgat gatcaaaact agcactgtta atggccttat caaaggcaaa aggattttga
     3961 tttttataga aaggactggc aatagcagga ttttcagagt aataaatcct atcatcgcct
     4021 tccaaaatcc agacctctgt taatagggga tagtgattaa aacggataga atattcttta
     4081 ctagtttgac ctgtatgaac cacaaaattc aagctttcta taacatgtga acttgggtgt
     4141 tcaaagctaa ataaagctcc aaaataatct tctttgtagg ttagcaaatc aattcgttga
     4201 tcctgacttt ttacaaagga gcaagtgtca tattctccat tcttacgatg gtaatgaatg
     4261 cgcatagggt agttatacat tttttatttt tcctttttac tttgtttcta tttcactaat
     4321 aaatttttgt caatctcgtc tcaattaaca gacatagtca tattctctaa actctgtttt
     4381 taaacgatcc attacaaact ttctagccat gcctcatctc tgacctggat accaagttct
     4441 tgtgcttttt gcagtttact tccagcgtct gcacctacca cgacgaggtc ggtcttttta
     4501 gaaacactac ctgtcacttt ggcacccaga ctttcgagtt tacttttagc ttctgagcgc
     4561 ttgagtcgtt ccaattttcc tgtcaatacc acggtcaaac ctgacaaggc cgcatccgct
     4621 actaccgtct gtcctttata gtccagattg accccagttt ctttcaattc tctgagcaga
     4681 atttcagagc cttctgtcgc aaaataagtc tgaagacttt tggcaatcac gccacctaga
     4741 ctttcaatac tagccacttc ctctgaatct gcctgataca gattttcaat tgaatggaaa
     4801 tattgaagta aaagctgact agccttgctt ccgacatgac gaattcccaa accaaataag
     4861 agcttctcgg cagaattttc ctttgatgct tggatagcct gatacagttt agcagcggac
     4921 ttttccttaa ccccctctaa aaggaggaaa tcctcttctt gcaaacgata aatatccgcc
     4981 acatccttga ctaaattagc agcaaaaagc ttctcaacaa tagatggacc aaggcctgta
     5041 atattcatag catcacgaga agcaaagtga atcaagcctt ccatgatttg agcagggcaa
     5101 cgcggattga tacaacgtag ggccacttca tcttcaaagt gcaacaagtc agagttacaa
     5161 cttggacagt ttgtagggat atctagtttt tcttcagaga cccgtttgga ctctaccaca
     5221 cgtaaaacgg cagggatgat gtcaccagcc ttatatacaa tgaccgtatc gtcttttcgg
     5281 atatcttttt cagcaatata atctacattg tgcagggtcg cacggctaac agtcgtaccg
     5341 gcaagttgta ctggtgttag attagcagtt ggagttacaa caccggtacg gccaactgtc
     5401 cagtcaactg ataagagttg agcttctttt tcttcagcag ggaacttgta ggctactgcc
     5461 cactttggag ccttaacggt aaaaccaagt tcttcttgac ttgctaggtc gttgaccttg
     5521 attaccactc catcaatatc gtaaggcaga ttttcccgtt cctgtcctac ttcttggata
     5581 aaattccaga tttcatctat gttttcagcc aagattcgct taggattgac cacaaaacct
     5641 agttgttcta ggtacttcaa acccttttct tggctatcac gagttgaagg gctggcttct
     5701 tgatagagaa acgttgcgag attacgcttg gcaactactg ctgtatccaa ctgacgcaga
     5761 gttcctgctg ccgcattacg aggattagca aattcaggct ctccattttc ttggcgcgct
     5821 tggttaactt ggtcaaagga agcgcgtggc atgtaacatt ccccacgaac tgtgatatct
     5881 agttcttctg tcaaagtcaa agggatgtcc ttaacacgct tgaggttttc tgtgatattt
     5941 tcaccaattg aaccatctcc acgtgttacc ccagcaacca aaatcccctt ttcataagtc
     6001 agcgagatag ataagccatc gattttcagc tcacaaatat aggtcggatg agccacttcc
     6061 ttacgaacac gcgcatcaaa agcatctagc tcctcacgtg aaaaagcatc ctgcaaacta
     6121 taaagaggat actgatgact gtatttttca aaaccatcta aaaccttgcc accaacacga
     6181 tgagtcggac tgtctgctag cacttgctct ggataagcag tttctaactc gaccaactca
     6241 cggtaaaggc ggtcatactc actgtctgaa accgagggat tatcgctggt atagtactca
     6301 gtcgcatagc gattgagcaa agcgactaac tcattcattc ttttattcat aagaccattt
     6361 taccataaaa caagccctcc tcacaaacga gaagggcgga aaaaacactt agtttgaaat
     6421 tatttttgaa actcaagcaa ccttatatca atttttcaaa atgagttcga acataaataa
     6481 acgatataca agacaagatg ataacaccac ttccaattat caggaaagaa gagagatgta
     6541 cacttggcaa gactgtcata aatccttttg caataggcat aaatagaata gctaaggtaa
     6601 aaattgtact cagtactctc ccaagaaatt cgctctcaac cttggtttgt acttgagtaa
     6661 aaaagtgaat attaaaaatc gtcataaaca attcacaaac taaatttcca gaaaaggaaa
     6721 gaaaagttgg aagtggtaat cccatcataa aaactccgac acctgtcaaa gccagtaaaa
     6781 tcaaaagatt ataaatatta gctttaattt tactagctag aagagcccca atgatggaac
     6841 caatagcccc catagttaaa atacttgcat aggctccttc tgacccgtaa agctgattcg
     6901 aaaagggaag tagaaattca aaagctgcaa aaaagaaatt aacgctggaa gctaccagca
     6961 aaaggaagaa aatttcttgc tgatgccaga tatagtgtaa cccatccttg atatctacaa
     7021 aaatatctct cccagtaaaa gcctttttct cttgaacttt tgcttcctct tttggaagga
     7081 aagccactag aacaaaagca atgaaaaaag tcagcgagtc tagcagtagc gtcatatgga
     7141 gacttgcaaa ctgtaaaaca aggaaggaaa gaacaggaga gctaacacct acaacctgca
     7201 aaaccagctc taagcgagaa ttatagatca caatctcatc tttctccacc acttcagtta
     7261 tgatagcttt attggctgtg cgagaaaagg caaaagcaat agcctgcaca atgttagcaa
     7321 caatcaaagc gccaatcatc cagctatcat tccttatgaa agaaatagcc agacaaagaa
     7381 tcccacaaac aagatctgcc gtcattaaaa tcttacgacg agaaaaacgg tctgaaataa
     7441 ctccgccaaa gggattgacg agaatagatg tgacgagctc agaaatctga tacattccta
     7501 aaactgtctg tcctatagtc cccatagaag ccaaccagac actatttcca taatcataga
     7561 gcatatttcc cattttattg atagccccac ggctaatcaa ctgcactgca tagcgattca
     7621 tattaaagct cctctcaaat tttgaaacta ttgtatcaaa accgaaagga gctttttatt
     7681 ttttccctta tttgggaaaa ttaacttttg acaaattttt cgtagtgttc ctgataatag
     7741 gctacttgct ctggaagacc taacacatca aaaatatgca tggcctcttg catctgctta
     7801 cagccttctt tacactgtcc tttttgatat aaggccaaac cttttaaata atggaaaaca
     7861 ttacgctcat aaagcttaat acctttgtca ataatcttct ctgtataagc ctcaaaatag
     7921 ttggcattat aaaaagaaga atgctctaaa caatgctggt aacaattgag ggccaaaatt
     7981 aacactaatc tcttatggcg actaatctct tggtaaaatt cctccctctc cataacttct
     8041 ctaccaatcc gagtgacata gtctacatcg tagaaactat agaggttacc gaaaagaatc
     8101 aactcataca tggtccattc ttctgttttg aagagataat ctgctacctt atccaaatca
     8161 tcctgcttca tatcataact cgcatctctt tgacaaatca gaccttgtag caaaatccag
     8221 ttcagctcaa aataaaggga agtcgtcgaa ctcttagact tttcaagttg ttctctttga
     8281 agcttttgaa aacctgcaat atcgtttgaa tagtaaagtg ggataatctg tgccatcata
     8341 gacacatgtt catgattatg aaaattcctt gccttatcca tgaaattttc gattgttaca
     8401 tgaatgttat ccaaaatctc aaagaaacgg gagactgcca ggtcagactc cccaagctca
     8461 aagcgagata actgagaggt agagcaggat tcgcctgctg cttcctttaa agaataattt
     8521 ccacttgttc gaaattcacg aaatactttt ccaagatgtt ccatctttac acctgatctg
     8581 ataattcttc ccactcaagc atagcttctt cctgacgatg gctgatttta tccagctcag
     8641 cctgtaattc catgagtttg tcggcatcgt ttgtttccaa catttgttca gaaatggctt
     8701 ggctttgact ttctagctct tcaatttcag cttctagact ttcgatttgt cgcatgagtt
     8761 tgcgaacttc tttttgactt tctttctggg cctgatagtc attgactgga cttgcttcct
     8821 ttgcttgatt gctagttgaa gcttcctcag tctgactcat ttctgctgtt gctttcttct
     8881 caacatagta gtcgtaatct ccaaggtaga gagttgaacc attctcagac aattccaaaa
     8941 catgagttgc cacacaattg ataaagtaac gatcatgact gacaaacagc aaggtaccat
     9001 caaagtcaat caaggcattt tctagcactt ccttactatc aatatccaag tggttggtcg
     9061 gctcatccag aatcaaaaag ttattgtttt ccatagacaa tttagctaaa agcaaacgag
     9121 ctttttcgcc accagatagc atgccgactg attttttaac atcatctcct gagaaaagga
     9181 aggctccaag acggttgcgg atttcaactt ctggtgtcag tttgaaatca ttccagagtt
     9241 catccagcac cgtattactt ggtgtcagct tgctttgggt ttggtcatag taaccaacct
     9301 caacattagc gccaaagcgc ttttctccct tgataaacgg aatttgatcc acgattgatt
     9361 tgataaaggt tgattttccg ataccattgg gaccaacgat agcaacagca ttcatcttac
     9421 gaaggtctag gttaatcggt tgtgacagga cttccccatc atagccaaca gccgcatttt
     9481 caacagtcaa aacaacattg cccgacgttt tttcagactg gaaggtcatg ttggctgctt
     9541 tcttgccagc ttccggcttg tccaaacgct ccattttttc tagttgttta cggcgagatt
     9601 gagcacgttt ggtcgttgaa gcacgaacta gattgcgatt gacaaagtct tccagagcag
     9661 cgatttcctt ctgttgcttt tcatagtttt ttgcctcagt agctagcttt tgctccttca
     9721 actcgacaaa acgagagtaa ttccccacat agcgatccaa ggaatgcttg gtcaaatcta
     9781 gcgtaattgt cgcaaccttg tccaagaaat aacggtcgtg gctgacgata atgagggctc
     9841 cgctatagtt taccaagtaa ttctctagcc aggagatggt ttcaatatcc aagtggttag
     9901 ttggctcgtc caagaccaag agattgggct tttcaaggag cattttagct agagccaaac
     9961 gagtattttg accacctgaa agttcagcta ttttcatctg ccacatagac tcgtcaaact
    10021 tgaatccatt caaaatcgct cgaatatcag cttcataggt aaagccgcct gcttggcgaa
    10081 aattctcaga taagtggtcg taatctgaca tcagtttatc caattcatcg ccagactttt
    10141 cacccatctc caactccatc tgacgaagtt gtttatctgt ccgacgtaag tcatcaaaga
    10201 catgaagcat ttcatcgtag atggtatttt cagactcaaa acggctatct tgggctaggt
    10261 aagacagaga aatatctttt ttcttattga tttctccgct agttggctcc tcttctccaa
    10321 ctaaaatctt caaaagagta gacttacctg caccattttt cccaacaaga gcaatccgat
    10381 ctcgttcatc aacctgcagg ttgatattat cgaaaagaac ctctcctgca aaagaacgtt
    10441 caattttatt agcttgtaaa ataatcatac aagtagtata gcatgtttcc ctaagtcatt
    10501 caagataatc gtaagtcttt tagtacaact tttataacat aaaataaact aaattatgta
    10561 tattttatat tagattcctt cactatcttg ttggattttc taaccagcta atcttgtttc
    10621 aaatagttat cgcacaagtc tattatttaa ttcttttcat tatttacgta c
//
LOCUS       DAVHSO010000076        10657 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.077, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000076 DAVHSO010000000
VERSION     DAVHSO010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10657)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10657)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10657
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.077"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..610
                     /locus_tag="VVR18_001966"
     CDS             <1..610
                     /locus_tag="VVR18_001966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEU6033435.1"
                     /translation="SKQDLLYPRKGKALKKQASTNFKPAGQSIEQRPEAINLRLENGH
                     YEIDTVLLTRAKNYCLLVLTDRKSRHQIIRLIPNKSAEVVNQALKLILKQHKILSITA
                     DNGTEFNRLSNVFSEEHIYYAHPYASWERGTNENHNRLIRRWLPKGTKKMTPKEVAFI
                     EKWINNYPKKCLDYKSPREDFWMANLNLKFSKMEIIFIKRFQ"
     gene            685..885
                     /locus_tag="VVR18_001967"
     CDS             685..885
                     /locus_tag="VVR18_001967"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit C"
                     /protein_id="HEU6033436.1"
                     /translation="MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLM
                     FLGVAFIEGTFFVTLVFSFIIK"
     gene            920..1636
                     /gene="atpB"
                     /locus_tag="VVR18_001968"
     CDS             920..1636
                     /gene="atpB"
                     /locus_tag="VVR18_001968"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HEU6033437.1"
                     /translation="MEESINPIISIGPVIFNLTMLAMTLLIVGVIFVFIYWASRNMTL
                     KPKGKQNVLEYVYDFVIGFTEPNIGSRYMKDYSLFFLCLFLFMVIANNLGLMTKIQTI
                     DGTNWWSSPTANLQYDLTLSFLVILLTHIESVRRRGFKKSIKSFMSPVFVIPMNILEE
                     FTNFLSLALRIFGNIFAGEVMTSLLLLLSHQAIYWYPVAFGANLAWTAFSVFISCIQA
                     YVFTLLTSVYLGNKINIEEE"
     gene            1650..2144
                     /gene="atpF"
                     /locus_tag="VVR18_001969"
     CDS             1650..2144
                     /gene="atpF"
                     /locus_tag="VVR18_001969"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HEU6033438.1"
                     /translation="MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEK
                     IASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLE
                     AGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQ
                     LGEA"
     gene            2144..2680
                     /locus_tag="VVR18_001970"
     CDS             2144..2680
                     /locus_tag="VVR18_001970"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HEU6033439.1"
                     /translation="MDKKTVKVIEKYSMPFVQLVLEKGEEDRIFSDLTQIKQVVEKTG
                     LPSFLKQVAVDESDKEKTIAFFQDSVSPLLQNFIQVLAYNHRANLFYDVLVDCLNRLE
                     KETNRFEVTITSAHPLTDEQKTRLLPLIEKKMSLKVRSVKEQIDESLIGGFVIFANHK
                     TIDVSIKQQLKVVKENLK"
     gene            2695..4200
                     /locus_tag="VVR18_001971"
     CDS             2695..4200
                     /locus_tag="VVR18_001971"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HEU6033440.1"
                     /translation="MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGL
                     ENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGES
                     LIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIG
                     RGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGAL
                     DYTIVVTASASQPSPLLFLAPYTGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLL
                     LRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNV
                     ISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYREL
                     EAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPV
                     DDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ"
     gene            4216..5094
                     /locus_tag="VVR18_001972"
     CDS             4216..5094
                     /locus_tag="VVR18_001972"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002895995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit gamma"
                     /protein_id="HEU6033441.1"
                     /translation="MAVSLNDIKTKIASTKNTSQITNAMQMVSAAKLGRSEEAARNFQ
                     VYAQKVRKLLTDILHGNGAGASTNPMLISRSVKKTGYIVITSDRGLVGGYNSSILKAV
                     MELKEEYHPDGKGFEMICIGGMGADFFKARGIQPLYELRGLADQPSFDQVRKIISKTV
                     EMYQNELFDELYVCYNHHVNTLTSQMRVEQMLPIVDLDPNEADEEYSLTFELETSREE
                     ILEQLLPQFAESMIYGAIIDAKTAENAAGMTAMQTATDNAKKVINDLTIQYNRARQAA
                     ITQEITEIVAGASALE"
     gene            5180..6586
                     /gene="atpD"
                     /locus_tag="VVR18_001973"
     CDS             5180..6586
                     /gene="atpD"
                     /locus_tag="VVR18_001973"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HEU6033442.1"
                     /translation="MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIV
                     LEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDL
                     EAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVG
                     KTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEP
                     PGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQP
                     TLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQ
                     LGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDE
                     EKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAF
                     RGVGSIEDVIAKAEKMGF"
     gene            6597..7016
                     /locus_tag="VVR18_001974"
     CDS             6597..7016
                     /locus_tag="VVR18_001974"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="HEU6033443.1"
                     /translation="MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAV
                     LAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLR
                     AERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL"
     gene            complement(7061..8074)
                     /locus_tag="VVR18_001975"
     CDS             complement(7061..8074)
                     /locus_tag="VVR18_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactonase family protein"
                     /protein_id="HEU6033444.1"
                     /translation="MKETVYFGTYTRRTSQGIYKADFDTETGQLSNLELFAAEPSPTY
                     LAFDQHQHLYTVGSQDDKGGIAAYQTDGTVLNHVVEEGAPHCYVAVDEKRDLVYAANY
                     HKGQVLVYKRQEDGSLLLSDMDQHSGQGPHENQASPHVHYTDLTPDHYLVTCDLGTDQ
                     VITYDLDQEGKLSKLYTYHSKPGAGSRHIIFHNHYKIAYLICELNSTIEVLIYDGVGE
                     FERMQVISTLPEAYEGFNGTAAIHLSKDGKYLYASNRGHDSIAVYTILADGSLELLEI
                     VPTHGQTPRDFDLTPDQKFLIVVHQDSDNATVFKRNCDNGRLAELSNDFHVPEAVCIR
                     FAP"
     gene            8218..9384
                     /locus_tag="VVR18_001976"
     CDS             8218..9384
                     /locus_tag="VVR18_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEU6033445.1"
                     /translation="MEQKEKHFSLSWFFKWFLDNKAITVFLVTLLLGLNLFILSKISF
                     LFSPVLDFLAVVMLPVILSGLLYYLLNPIVDWMEKHKVNRVIAITIVFVIIALFIIWG
                     LAVAIPNLQRQVLTFARNVPVYLEDIDRIVNGLVAQHLPDDFRPQLEQVLTNFSSQAT
                     VLASKVSSQAVNWVSAFISGASQVIVALIIVPFMLFYLLRDGKGLRNYLTQFIPRKLK
                     EPVGQVLSDVNQQLSNYVRGQVTVAIIVAVMFIIFFKIIGLRYAVTLGVTAGILNLVP
                     YLGSFLAMLPALVLGLIAGPVMLLKVVIVFIVEQTIEGRFVSPLILGSQLNIHPINVL
                     FVLLTSGSMFGIWGVLLGIPVYASAKVVISAIFEWYKVVSGLYELEGEEVKSEQ"
     gene            9374..10603
                     /locus_tag="VVR18_001977"
     CDS             9374..10603
                     /locus_tag="VVR18_001977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HEU6033446.1"
                     /translation="MNNSQQMLQALEEQDLTKAEHYFAKALENDSSDLLYELATYLEG
                     IGFYPQAKEIYLKIVEDFPEVHLNLAAIASEDGQIEEAFTYLEEIQADSDWYVSSLAL
                     KADLYQLEGLTDVAREKLLEALTYSEDSLLILGLAELDSELENYQAAIQAYAQLDNRS
                     IYEQTGISTYQRIGFAYAQLGKFETATEFLEKALELEYDDLTAFELASLYFDQEEYQK
                     ATLYFKQLDTISHDFEGYEYGYSQALHKEHQVQEALRIAKQGLEKNPFETRLLLAASQ
                     FSYELHDASGAENYLLAAKEDAEDTEEILLRLATIYLEQERYEDILDLQSEEPENLLT
                     KWMIARSYQEMDDLDTAYEHYQELTGDLKDNPEFLEHYIYLLRELGHFEEAKVHAHTY
                     LKLVPDDVQMQELFERL"
BASE COUNT         3132 a         1957 c         2354 g         3214 t
ORIGIN      
        1 aagcaagcag gatctgcttt accctagaaa aggaaaagcg cttaagaaac aggccagcac
       61 caactttaaa cctgctggtc aatccatcga acagcggcct gaagctatca atcttcgctt
      121 ggagaatggg cattatgaga ttgatacggt tctacttacg agagcgaaaa actactgctt
      181 gcttgtcttg acggatcgaa aaagtagaca tcagatcatc cgattgattc caaataaaag
      241 tgctgaggtg gtcaatcagg ctctaaaact catcttaaaa caacacaaga ttctttccat
      301 cacggcagat aatggaacgg aattcaatcg cttgtctaat gtattttctg aggagcacat
      361 ttattatgca catccctatg cctcttggga aaggggaact aatgagaatc acaacaggct
      421 cattcgtaga tggttaccta agggaaccaa gaaaatgact cccaaagaag tcgcattcat
      481 cgaaaagtgg attaacaact atcctaaaaa atgcttggac tacaagtcac ccagagaaga
      541 cttctggatg gctaacttga acttgaaatt tagcaaaatg gaaataattt ttattaaacg
      601 cttccaatag cggttaaaag ttgacaaatt taaattttag gactacacta agtaagtaaa
      661 ttttatttta aaggagaatt tgttatgaat ttaacatttt taggcttatg tattgcctgt
      721 atgggcgtat ctgtcggtga aggtttattg atgaatggac tgtttaaatc agtagcacgc
      781 caaccagata tgctttctga gtttcgtagt ttgatgtttt taggtgttgc ctttattgaa
      841 ggaactttct ttgtaactct tgtcttctca tttattatca aataaataca tggaacgaga
      901 agaaaaggga ggattttaga tggaagaaag tattaatcca atcatctcta ttggtcctgt
      961 tatcttcaat ctgactatgt tagccatgac tttgttgatt gtgggagtta tttttgtctt
     1021 tatttattgg gcaagccgca atatgacctt gaaacccaaa ggaaagcaaa atgtacttga
     1081 gtatgtctat gactttgtta ttggatttac agaacctaac attggttcgc gctacatgaa
     1141 agattactca ctctttttcc tttgtttatt ccttttcatg gtgattgcca ataaccttgg
     1201 cttaatgaca aagattcaaa cgatcgatgg gactaactgg tggagttcgc caaccgctaa
     1261 tttacagtat gacttaacct tatcttttct tgtcattttg ttgacacata tagaaagcgt
     1321 tcgtcgtcgt ggatttaaaa aaagtataaa atcttttatg agtcctgttt ttgtcatacc
     1381 gatgaatatc ttggaagaat ttacaaactt cttatctttg gctttgcgga tttttgggaa
     1441 tatctttgca ggagaggtca tgacgagttt gttacttctt ctttcccacc aagctattta
     1501 ttggtatcca gtagcctttg gagctaattt ggcttggact gcattttctg tctttatttc
     1561 ctgcatccaa gcttatgttt ttactctttt gacatctgtg tatttaggga ataagattaa
     1621 tattgaagag gaatagaaag gagtaactga tgcacgtaac agtaggtgaa ttaattggta
     1681 attttatttt aatcactggc tcttttattc ttttgctagt cttgattaaa aaatttgcat
     1741 ggtctaatat tacaggcatt ttcgaagaaa gagctgaaaa aattgcttca gatattgaca
     1801 gagctgaaga agcccgtcaa aaagcagaag tattggctca aaaacgcgaa gatgaattgg
     1861 ctggtagccg taaagaagct aagacaatca ttgaaaatgc aaaggaaaca gctgagcaaa
     1921 gtaaggctaa tatcttagca gatgctaaac tagaagcagg acacttaaaa gaaaaagcca
     1981 atcaagaaat tgctcaaaat aaagtagaag ctttacagag tgttaagggt gaggtcgcag
     2041 atttgaccat cagcttagct ggtaaaatca tctcacaaaa ccttgacagt catgcccata
     2101 aagcactcat tgatcagtat atcgatcagc taggagaagc ttaatggaca agaaaacagt
     2161 aaaggtaatt gaaaaataca gcatgccttt tgtccaattg gtacttgaaa aaggagaaga
     2221 agaccgtatc ttttcagact tgactcaaat caagcaagtt gttgaaaaaa caggtctgcc
     2281 ttctttttta aaacaagtgg cagtagacga gtcggataag gaaaaaacaa ttgctttttt
     2341 ccaagattct gtgtcgcctt tattacaaaa ctttatccag gttctggcct acaatcacag
     2401 agcaaatctt ttttatgatg tgcttgtaga ttgcttgaac cgacttgaaa aagaaacaaa
     2461 tcgatttgaa gtgacgatta cgtctgctca tcctctaact gatgaacaga agactcgttt
     2521 gctccctttg attgagaaaa aaatgtctct gaaagtaagg agtgtaaaag aacaaatcga
     2581 tgaaagtctc attggtggtt ttgtcatttt tgccaatcac aagacaattg atgtgagtat
     2641 taaacaacaa cttaaagttg ttaaagaaaa tttgaaatag aaagtggtgt tcttttggca
     2701 attaacgcac aagaaatcag cgctttaatt aagcaacaaa ttgaaaattt caaacccaat
     2761 tttgatgtga ctgaaacagg tgttgtaacc tatatcgggg acggtatcgc gcgtgctcat
     2821 ggccttgaaa atgtcatgag tggagagttg ttgaattttg aaaacggctc ttatggtatg
     2881 gctcaaaact tggagtcaac agacgttggt attatcatcc taggtgactt tacagatatc
     2941 cgtgaaggcg atacaatccg ccgtacaggg aaaatcatgg aagtccctgt aggtgaaagt
     3001 ctgattggtc gtgttgtgga tccgcttggt cgtccagttg acggtcttgg agaaatccac
     3061 actgataaaa ctcgtccagt agaagcacca gctcctggtg ttatgcaacg taagtctgtt
     3121 tcagaaccat tgcaaactgg tttgaaagct attgacgccc ttgtaccgat tggtcgtggt
     3181 caacgtgagt tgattatcgg tgaccgtcag acagggaaaa caaccattgc gattgataca
     3241 atcttgaacc aaaaagatca agatatgatc tgtatctacg tcgcgattgg acaaaaagaa
     3301 tcaacagttc gtacgcaagt agaaacactt cgtcagtacg gtgccttgga ctacacaatc
     3361 gttgtgacag cctctgcttc acaaccatct ccattgctct tcctagctcc ttatactggg
     3421 gttgctatgg cggaagaatt tatgtatcaa ggtaagcatg ttttgattgt atacgatgat
     3481 ctatcaaaac aagcggtagc ttatcgtgaa ctatcgctct tgcttcgtcg tcctccaggt
     3541 cgtgaagcct tcccagggga tgttttctat ctccacagcc gtttgcttga gcgctcagct
     3601 aaagtttctg atgaacttgg tggtggatca attacagccc taccatttat cgagacacaa
     3661 gcaggagata tctcagccta tatcgcaacc aacgtgattt ctatcactga tggacaaatc
     3721 ttccttggcg atggcctctt caatgcaggt attcgtccag ccatcgatgc gggttcatct
     3781 gtatctcgtg taggtggttc tgcacaaatc aaagccatga agaaggttgc tggtacactt
     3841 cgtatcgacc ttgcttcata ccgtgagtta gaagccttta ctaagtttgg ttctgacttg
     3901 gacgcagcaa cacaggctaa gttgaaccgt ggacgtcgta ccgttgaggt cttgaaacaa
     3961 cctgttcaca aaccattacc tgttgagaaa caagtaacca ttctttatgc tttgacacat
     4021 ggtttcttgg atactgttcc agtagatgat attgttcgtt tcgaggaaga gttccatgcc
     4081 ttctttgatg ctcaacatcc agagattttg gaaaccattc gtgatacaaa agacttgcca
     4141 gaagaagcag tcttggatgc tgcgattaca gagtttctca atcaatctag cttccaataa
     4201 gaatagaggt gtcagatggc agtgtctcta aatgatatta aaacaaaaat cgcctcaaca
     4261 aaaaatacga gtcaaatcac taatgccatg caaatggtat cggctgctaa gctaggtcgc
     4321 tctgaagaag ctgctcgcaa cttccaagtt tacgctcaga aagtgcgtaa acttttgaca
     4381 gatatccttc atggtaatgg agctggtgct tcaactaatc cgatgttgat tagccgttct
     4441 gtgaagaaga caggctatat cgttatcact tcagaccgcg gtttggttgg aggttataat
     4501 tcctctattt tgaaagctgt tatggagttg aaagaagaat accacccaga cggtaaaggt
     4561 tttgaaatga tctgtatcgg tgggatggga gctgatttct ttaaggctcg cggtattcaa
     4621 ccactttatg aattacgtgg cttggcagac caacctagct ttgatcaagt tcgtaagatt
     4681 atttcaaaaa ctgttgaaat gtaccaaaat gaactctttg atgagcttta tgtttgctac
     4741 aaccaccatg tcaatacgct aaccagtcaa atgcgtgtgg aacaaatgct tccgattgtt
     4801 gacttggatc caaatgaagc ggatgaagag tacagcttga cttttgaatt ggaaaccagc
     4861 cgagaagaaa ttctggagca gttgttgcct cagtttgcag aaagtatgat ttacggtgcc
     4921 attatcgatg ccaagacagc tgagaatgct gcgggtatga cagccatgca aacagcgaca
     4981 gataatgcta agaaagtcat caatgatttg acaattcagt ataaccgtgc cagacaggcg
     5041 gcgattacac aagaaattac agaaatcgta gcaggtgcta gtgccttaga ataggctcta
     5101 gtccagctcg tatgaaaatg aacttaggac ctagttgagc taggaaccga cagtatctta
     5161 tatagaatag gagaaggaga tgagttcagg taaaattgct caggttatcg gtcccgttgt
     5221 agacgttttg tttgcagcag gggaaaaact tcctgagatt aacaatgcac ttgtcgtcta
     5281 caaaaatgac gaaagaaaaa caaaaatcgt ccttgaagta gccttggagt taggagatgg
     5341 tatggttcgt actatcgcca tggaatcaac agatgggttg actcgtggaa tggaagtatt
     5401 ggacacaggt cgtccaatct ctgtaccagt aggtaaagaa actttgggac gtgtcttcaa
     5461 cgttttggga gataccattg atttggaagc tccttttaca gaagacgcag agcgtcagcc
     5521 aattcataaa aaagctccaa cttttgatga gttgtctacc tcttctgaaa tccttgaaac
     5581 agggatcaag gttattgacc ttcttgcccc ttaccttaaa ggtggtaaag ttggactttt
     5641 cggtggtgcc ggagttggta aaaccgtctt aatccaagaa ttgattcaca acattgccca
     5701 agagcacggt ggtatttcag tatttactgg tgttggggaa cgtactcgtg aggggaatga
     5761 cctttactgg gaaatgaaag aatcaggcgt tatcgagaaa acagccatgg tctttggtca
     5821 gatgaatgag ccaccaggag cacgtatgcg tgttgccctt actggtttga caatcgctga
     5881 atacttccgt gatgtggaag gccaagacgt gcttctcttt atcgataata tcttccgttt
     5941 cactcaggct ggttcagaag tatctgccct tttgggtcgt atgccatcag ccgttggtta
     6001 ccaaccaaca cttgctacgg aaatgggtca attgcaagaa cgtatcacat caaccaagaa
     6061 gggttctgta acctctatcc aggctatcta tgtgccagcg gatgactata ctgacccagc
     6121 gccagcaaca gccttcgctc acttggattc aacaacaaac ttggaacgta aattggtaca
     6181 attgggtatc tacccagccg ttgacccact tgcttcaagc tcacgtgcct tggcacctga
     6241 aatcgttgga gaagagcact atgcagttgc tgctgaagta aaacgtgtcc ttcaacgtta
     6301 ccatgaattg caagatatca ttgctatcct tggtatggat gagctttctg atgaagaaaa
     6361 gaccttggtt gctcgcgccc gtcgtatcca gttcttcttg tcacaaaact tcaacgttgc
     6421 ggaacaattt actggtcagc caggttctta tgttccagtt gctgaaactg tacgtggctt
     6481 taaggaaatc cttgatggta aatacgacca cttgccagaa gatgccttcc gtggtgtagg
     6541 ttctatcgaa gatgtgattg caaaagctga aaaaatggga ttttaagagg tgacctatgg
     6601 ctcagttaac tgtccagatc gtgacaccag atggtctcgt ctatgatcac catgccagct
     6661 atgtatcggt tcgaactctg gatggtgaga tggggatctt gccacgacat gaaaatatga
     6721 ttgcggtttt agcagttgat gaagtaaagg taaaacgtat cgatgataaa gatcacgtga
     6781 actggattgc agtaaacggt ggcgttattg aaattgccaa tgatatgatc acaatcgtcg
     6841 ctgactctgc agaacgtgct cgtgatatcg atattagccg tgcagaacgt gccaaacttc
     6901 gtgcagaacg tgcaattgaa gaagcacaag acaaacattt gattgaccaa gaacgtcgtg
     6961 ctaagattgc tttgcaacgt gccattaacc gtattaatgt cggaaataga ctataagaaa
     7021 aaatgaactt gaaaatacca agttcatttt ttatggtgtt ttaaggagca aaacggatgc
     7081 agactgcttc gggaacatgg aagtcgttgg agagttctgc tagacgacca ttgtcacaat
     7141 tacgtttaaa gacagttgca ttgtcagagt cttgatggac aacaatgaga aatttttggt
     7201 cgggtgtcaa atcaaaatca cgtggagtct gaccatgcgt tggaacgatt tctaataact
     7261 ctaagctacc gtccgcaagg atggtatata ctgcgataga atcatggcca cggttagaag
     7321 cgtagaggta tttaccgtct ttagagagat gaatagcagc ggttccatta aagccttcgt
     7381 aagcttctgg taaagttgaa ataacctgca tacgttcaaa ttcgccaacg ccatcgtaga
     7441 ttaaaacttc gatagtacta ttgagttcac aaatgagata agcgatttta tagtggttat
     7501 ggaaaatgat atggcgtgag cctgctcctg gcttgctgtg ataggtatag agcttagata
     7561 attttccttc ttgatcgagg tcataggtga tgacttggtc agttcccaag tcgcaggtca
     7621 ctagatagtg gtcaggtgtt aaatctgtat agtgaacatg gggggaagct tgattttcat
     7681 gtggaccttg gccactgtgt tgatccatat cactaagtag aagactacca tcttcctggc
     7741 gtttataaac aaggacttgt cccttgtgat agttggctgc gtaaaccaaa tcacgctttt
     7801 catcgacagc aacataacag tggggagctc cttcttcaac aacatgattt aacacagtcc
     7861 cgtcagtttg ataggctgca attcccccct tatcgtcttg gctaccaaca gtgtataaat
     7921 gttggtgctg gtcaaaggca aggtaggttg gacttggctc agctgcaaaa agttctagat
     7981 ttgaaagctg accagtttct gtatcaaagt ctgccttgta aatcccttga gaagtacgac
     8041 gtgtataagt tccaaaataa acagtttctt tcattactat acctctgtgt aaagataaga
     8101 ctattatatc acaaaaacaa gtaaattaaa gatatccaat tagatgtaag cactttaaaa
     8161 aagagttatt ttgtttcaaa aatggtataa tgagagaaca atagaaagga agtatttatg
     8221 gagcaaaaag agaaacattt tagcctatct tggtttttca agtggttttt agataacaag
     8281 gcaattacgg tatttttagt aaccttatta ttgggactga atctttttat tttaagtaag
     8341 attagttttc tattttcacc tgttttagac tttttagcag ttgtgatgtt gccagtcatt
     8401 ttgtctggtt tgttatatta tttgttgaat cctattgttg attggatgga gaagcataag
     8461 gttaatcgtg ttatagctat cactattgtc tttgttatca tcgctctctt tatcatttgg
     8521 ggcttggcag tcgccattcc aaatctgcaa cgtcaggttt tgacctttgc aagaaacgtt
     8581 cctgtttact tagaagatat agataggatt gttaatggat tggtagccca gcacctgcca
     8641 gatgatttca gacctcaatt agagcaagtt ttgaccaatt tttctagcca ggctacagtt
     8701 ttggcaagta aggtttcatc tcaggcagtc aactgggtga gtgcctttat tagcggagct
     8761 tctcaagtga ttgttgcctt gattatcgtt cctttcatgc tcttttatct cttgcgtgat
     8821 gggaaaggct tgcgtaacta tttgacccaa ttcattccaa gaaaattgaa ggaacctgtt
     8881 ggacaagttc tatcagatgt gaatcaacag ttgtccaact atgttcgagg gcaagtgaca
     8941 gtggctatta ttgtagcagt aatgtttatc atcttcttca agattattgg tctacgctat
     9001 gcggttacgc tgggggttac tgctggtatt ttaaatctgg tcccttatct tggtagcttt
     9061 ctagccatgc ttcctgctct agtattgggt ttgattgctg gtccagtcat gcttttgaaa
     9121 gtagtgattg tctttatcgt agaacaaact attgaaggcc gttttgtctc tccattgatt
     9181 ttgggaagtc aattaaacat ccatcctatt aatgttctct ttgttttgtt aacttcagga
     9241 tctatgtttg gtatctgggg agttttactt ggtattccgg tttatgcctc tgctaaggtt
     9301 gtcatttcag ccattttcga atggtataag gtagtcagtg gtctatatga attagagggt
     9361 gaggaagtca agagtgaaca atagtcaaca gatgttacag gctttggagg agcaagattt
     9421 aactaaggct gagcattatt tcgccaaagc tttagaaaat gattcaagtg atcttctgta
     9481 tgagttggca acttatcttg aagggattgg tttctatcct caggccaagg aaatttacct
     9541 gaaaattgta gaggattttc cagaggttca tcttaatcta gctgcaattg ctagcgagga
     9601 tggtcaaata gaagaagcct ttacctatct tgaggaaatc caagctgaca gtgactggta
     9661 tgtctcgtct ttggctctga aggcagacct ttaccagctg gaaggtttga cagatgtggc
     9721 acgtgagaaa ttattggagg ccttgaccta ctcagaggat tctctcttga tattgggttt
     9781 ggcagagttg gatagtgagt tggaaaatta ccaagcggct attcaagcct atgcccagtt
     9841 agataatcgc tcgatttatg agcaaacggg catttccacc tatcaacgaa ttggctttgc
     9901 ctatgctcag ttagggaaat ttgaaacggc tactgagttt ttagaaaaag ccctggagtt
     9961 agaatacgat gacttaacag cttttgagtt ggccagtctt tattttgatc aagaagaata
    10021 tcaaaaagcc accctctact ttaagcagct tgataccatt tctcatgact ttgaaggcta
    10081 tgagtatggg tacagtcagg ctttacataa ggaacatcaa gttcaagaag ccctgcgtat
    10141 cgctaagcaa ggattagaga aaaatccctt tgaaactcgc ctcttgctag ctgcttcaca
    10201 attttcttat gaattgcatg atgctagtgg tgcagaaaat tatcttcttg ctgcaaaaga
    10261 agacgctgag gatacagaag aaatcttgct tcgtttagcc actatttatc tggagcagga
    10321 gcgttatgag gatattctag acttgcagag tgaggagcca gaaaatcttt tgaccaagtg
    10381 gatgattgct cgttcttatc aagaaatgga cgatttggat actgcttatg agcattatca
    10441 agagttgaca ggagatttga aggacaatcc agaatttctg gaacactata tctatctctt
    10501 gcgtgaattg ggacattttg aagaagcaaa agtccatgct cacacttact taaaactggt
    10561 tccagatgat gtgcaaatgc aagaactgtt tgagagattg taagaatgtt taaacatata
    10621 gaactgtagt ttatctcttt tgatagctac ggttttt
//
LOCUS       DAVHSO010000077        10638 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.078, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000077 DAVHSO010000000
VERSION     DAVHSO010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10638)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10638)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10638
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.078"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            248..2176
                     /gene="glgB"
                     /locus_tag="VVR18_001978"
     CDS             248..2176
                     /gene="glgB"
                     /locus_tag="VVR18_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1,4-alpha-glucan branching protein GlgB"
                     /protein_id="HEU6033447.1"
                     /translation="MDNREALKTFMTGENFYLQHYLGAHREELNGEHGYTFRVWAPNA
                     QAVHLVGDFTNWIENQIPMVRNDFGVWEVFTNMAQEGHIYKYHVTRQNGHQLMKIDPF
                     AVRYEARPGTGAILTELPEKKWKDGLWLARRKRWGFEERPVNIYEVHAGSWKRNSDGS
                     PYSFAQLKDELIPYLVEMNYTHIEFMPLMSHPLGLSWGYQLMGYFALEHAYGRPEEFQ
                     DFVEECHTHNIGVIVDWVPGHFTINDDALAYYDGTPTFEYQDHNKAHNHGWGALNFDL
                     GKNEVQSFLISCIKHWIDVYHLDGIRVDAVSNMLYLDYDDAPWTPNKDGGNLNYEGYY
                     FLQRLNEVIKLEYPDVMMIAEESSSATKITGMKEIGGLGFDYKWNMGWMNDILRFYEE
                     DPIYRKYDFNLVTFSFMYVFKENYLLPFSHDEVVHGKKSMMHKMWGDRYNQFAGLRNL
                     YTYQICHPGKKLLFMGSEYGQFLEWKSEEQLEWSNLEDPMNAKMKYFASQLNQFYKDH
                     RCLWEIDTSYDGIEIIDADNRDQSVLSFIRKGKKGEMLVCIFNMVPVERKDFTIGLPV
                     AGIYEEVWNTELEEWGGVWKEHNQTVQTQEGLWKDYEQTLTFTLPAMGASVWKIKRRL
                     KSTKTVTNKNPKGVENEK"
     gene            2166..3308
                     /locus_tag="VVR18_001979"
     CDS             2166..3308
                     /locus_tag="VVR18_001979"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000787267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HEU6033448.1"
                     /translation="MKNEMLALILAGGQGTRLGKLTQSIAKPAVQFGGRYRIIDFALS
                     NCANSGIHNVGVVTQYQPLALNNHIGNGSSWGLDGINSGVSILQPYSASEGNRWFEGT
                     SHAIYQNIDYIDSVNPEYVLILSGDHIYKMDYDDMLQSHKDNNASLTVAVLDVPLKEA
                     SRFGIMNTDANNRIVEFEEKPAQPKSTKASMGIYIFDWQRLRNMLVAAEKSKVGMSDF
                     GKNVIPNYLESGESVYAYEFSGYWKDVGTIESLWEANMEYISPENALDSRNRQWKIYS
                     RNLISPPNFLGANAHVEDSLVVDGCFVDGTVKHSILSTGAQVREGAEVLDSVIMSGAI
                     IGQGAKIKRAIIGEGAIISDGVEIDGTDEVQVVGYNEVVGVATDED"
     gene            3298..4437
                     /gene="glgD"
                     /locus_tag="VVR18_001980"
     CDS             3298..4437
                     /gene="glgD"
                     /locus_tag="VVR18_001980"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HEU6033449.1"
                     /translation="MKIDKYSAILGNTVGFHDMSTLTDHRPVASLPFDGKYRLIDFPL
                     SSLANAGVRSVFGIFQQDNISSVFDHIRSGREWGLSTLLSHYYLGIYNTRVESSTVGK
                     EYYQQLLTYLKRSGSNQTVALNCDVLINIDLNQVFHLHSTTKEPITVVYKKLAKKDIS
                     EVNAILDVDETDHVLSHKLFDSKSTAETFNMSTDIFVVDTPWLIEHLEEEAKKEHPEK
                     LRYVLRDLAVKEGAFAYEYTGYLANIHSVKSYYQANIDMLESQKFYSLFSPNQKIYTK
                     VKNEEPTYYANTSKVSTSQFASGSIIEGQVANSVLSRNIHVHKDSLVKDSLLFPRVVI
                     GEGAQVEYAILDKGVEVEPGVVIRGTAEHPVVVKKGAKVTEDIHS"
     gene            4434..5867
                     /gene="glgA"
                     /locus_tag="VVR18_001981"
     CDS             4434..5867
                     /gene="glgA"
                     /locus_tag="VVR18_001981"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HEU6033450.1"
                     /translation="MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYY
                     DMVEAKFGSQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDF
                     DDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYRWIQAYEDIETVL
                     TIHNLEFQGQFSEGMLGDLFGVGFERYADGTLRWNNCLNWMKAGILYANRVSTVSPSY
                     AHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAK
                     NKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPA
                     FEGAFSWFAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGT
                     LPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNL
                     QKQAMESDFSWDTACKSYLDLYHSLVN"
     gene            5926..6571
                     /gene="serB"
                     /locus_tag="VVR18_001982"
                     /pseudo
     CDS             5926..6571
                     /gene="serB"
                     /locus_tag="VVR18_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000084485.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoserine phosphatase SerB"
     gene            6580..7695
                     /locus_tag="VVR18_001983"
     CDS             6580..7695
                     /locus_tag="VVR18_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HEU6033451.1"
                     /translation="MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDG
                     GEGTVDAIRHSLDLKEKWIQVTDPFGQKEAMRYFQKGELALFEVADLVGLGKIPLEKR
                     NPLQIQTCGIGELILHLISKGIKDIYIGVGGTASNDGGLGIAAGLGYQFYDRDGNVLP
                     ASGQSLLNLASVSTENCYKIPEGVQIHILADVVSPLCGHQGATYTFGNQKGLHPTMFA
                     VVDQAIQDFYEKFSPATLEIKGAGAGGGLAGGLCAFAQASIVSGIDTCLDLINFDKKV
                     SDADLVVVGEGRLDSQSFAGKAPIGVAKRTPVGVPVIAICGSLAEDLPPLPFENIQAV
                     FSILEKSEPLEDSLKNASLYLERTAANIGHLLNMCKI"
     gene            complement(7692..8138)
                     /locus_tag="VVR18_001984"
     CDS             complement(7692..8138)
                     /locus_tag="VVR18_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YueI family protein"
                     /protein_id="HEU6033452.1"
                     /translation="MTDLSKQLLEKAHGGLKINPDEQRRYLGTFEERVLGYVDIDTAN
                     SPQLEKGFLFILENLQEKAEPLFVKISPTIEFDKQVFYLKEAKETDSQATIVSEEHIT
                     SPFGLVIHSNAPVQVEEKDLRLAFPKLWEVKKEEPAKTSLWKKWFS"
     gene            8302..9606
                     /gene="eno"
                     /locus_tag="VVR18_001985"
     CDS             8302..9606
                     /gene="eno"
                     /locus_tag="VVR18_001985"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HEU6033453.1"
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTG
                     EHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
                     KGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPI
                     AFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDG
                     VETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQID
                     YLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQE
                     GAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQ
                     IKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK"
     gene            complement(9744..10172)
                     /locus_tag="VVR18_001986"
     CDS             complement(9744..10172)
                     /locus_tag="VVR18_001986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEU6033454.1"
                     /translation="MRKHGFISKRYYQVAIPFTRLFCLVSIDYINCLSETTDKNWHKS
                     DRIFVTNTGKPVHSSILSKSLQRANERLKKPIPKHLSPHIFRHTTISILSENKIPLKT
                     ITDRVGHSDSEVTTSIYTHVTKNMKDEAINVLDKVMKKIF"
     gene            complement(10090..10281)
                     /locus_tag="VVR18_001987"
                     /pseudo
     CDS             complement(10090..10281)
                     /locus_tag="VVR18_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(10381..10638)
                     /locus_tag="VVR18_001988"
                     /pseudo
     CDS             complement(10381..10638)
                     /locus_tag="VVR18_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
BASE COUNT         3191 a         1890 c         2316 g         3241 t
ORIGIN      
        1 agacattgtt agaaattaga ttaaagtcct taatcgattt gcgcatgttt tatttcattt
       61 cactatagta gaaaaagaaa ggcgttttcg caattttttg aaaaaatatt gatttacaat
      121 tgaacgagta agtgaacttg ttgtagattt tcaaaataat taaagaagta tagtaattta
      181 cttgaatctt ctctaaaaag gtagtataac aaaaacatag aaaacgctta caggagaaag
      241 ggagtatatg gataatagag aagcattaaa aacctttatg acgggtgaaa atttttatct
      301 ccaacattat ctaggagcac atagggaaga actaaatgga gagcatggct ataccttccg
      361 tgtttgggca cctaatgctc aggctgttca cttggttggt gattttacca actggattga
      421 aaatcagatt ccaatggtaa gaaatgattt tggggtctgg gaagtcttta ccaatatggc
      481 tcaagaaggg catatttaca aatatcatgt cacacgtcaa aatggtcatc aactgatgaa
      541 gattgaccct tttgctgtca ggtatgaggc tcgtccagga acaggggcaa tcttaacaga
      601 gcttcctgag aagaaatgga aggatggact ttggctggca cgaagaaaac gttggggctt
      661 tgaagagcgt cctgtcaata tttatgaagt tcacgctgga tcatggaaaa gaaattctga
      721 tggcagtcct tatagttttg cccagctcaa ggatgaactc attccttatc tcgttgaaat
      781 gaactatact catattgagt ttatgccctt gatgtcccat cctttgggct tgagttgggg
      841 gtatcagctt atgggttact tcgctttaga gcatgcttat ggccgaccag aggagtttca
      901 agattttgtc gaggagtgtc atacccataa tattggggtt attgtggact gggtaccagg
      961 tcactttacc atcaacgatg atgccttagc ctattatgat gggacaccga cttttgaata
     1021 ccaagaccat aataaggctc ataaccatgg ttggggtgcc cttaattttg accttggaaa
     1081 aaatgaagtc cagtccttct taatttcttg cattaagcat tggattgatg tctatcattt
     1141 ggatggtatt cgtgtggatg ctgttagcaa catgctctat ttggactatg atgatgctcc
     1201 atggacacct aataaagatg gcggaaatct caactatgaa ggttattatt tccttcagcg
     1261 cttgaatgag gttattaagt tagaatatcc agatgtgatg atgattgcag aagaaagttc
     1321 gtctgcgacc aagattacgg gaatgaaaga gattggtggt ctaggatttg actacaaatg
     1381 gaacatgggc tggatgaatg atatcctccg tttctacgaa gaagatccga tctatcgtaa
     1441 atatgacttt aacctggtga ctttcagctt tatgtatgtt ttcaaggaga attatctctt
     1501 gccattctcg cacgatgaag tggttcatgg caagaagagt atgatgcata agatgtgggg
     1561 agatcgttac aatcaatttg caggcttgcg caatctctat acgtaccaaa tttgtcaccc
     1621 tggtaagaaa ttgctcttca tgggtagcga atacggtcaa ttcctagaat ggaaatctga
     1681 agaacagttg gaatggtcta acctagaaga cccaatgaat gctaagatga agtatttcgc
     1741 ttctcagcta aaccagtttt acaaagatca tcgctgtctg tgggaaattg ataccagcta
     1801 tgatggtatt gaaatcattg atgcggataa tcgagaccag agtgttcttt cctttattcg
     1861 taagggtaaa aagggagaaa tgttagtctg tatctttaat atggtacctg ttgagcggaa
     1921 agattttaca atcggactac ccgttgcagg aatttacgaa gaagtatgga atactgagtt
     1981 ggaagagtgg ggaggcgttt ggaaagaaca taatcaaact gttcaaacgc aagaaggact
     2041 atggaaagat tatgagcaga ccttaacctt taccctaccg gctatgggag caagtgtatg
     2101 gaaaatcaaa cgtcgcttga aatctactaa aaccgtcaca aataaaaacc caaaaggagt
     2161 agaaaatgaa aaatgaaatg ttagctttga ttcttgctgg tgggcaagga actcgtctcg
     2221 gtaaactcac tcaaagcatc gcaaaaccag ctgtgcaatt tggtgggcgc taccgtatca
     2281 ttgactttgc actatcaaac tgtgccaact cagggattca taatgttggg gtcgttacac
     2341 agtatcaacc acttgctctc aacaaccata ttgggaatgg ttcaagctgg ggactagacg
     2401 gtattaattc aggtgtctct attcttcaac cttattctgc aagtgaagga aatcgttggt
     2461 ttgaggggac tagtcacgct atttaccaaa atatcgacta tatcgacagt gtcaatcctg
     2521 agtatgtctt gattttgtct ggggatcaca tctacaaaat ggactatgat gatatgctcc
     2581 agtctcataa ggataataat gccagcttga cagtagcagt tttagacgtc cctcttaaag
     2641 aagcaagccg ttttggtatc atgaacacag atgctaacaa tcgtattgtt gaatttgaag
     2701 aaaaaccagc tcaacctaaa tctacaaaag cttctatggg aatctacatt tttgattggc
     2761 aacgccttcg taatatgtta gtcgctgctg aaaagagcaa ggttggcatg tcagactttg
     2821 gtaaaaatgt cattccaaat taccttgagt caggtgaaag tgtttatgct tacgaattta
     2881 gtggttattg gaaagatgtt ggtactattg agtcactttg ggaagcgaac atggagtata
     2941 tttctccaga aaatgccttg gatagtcgta accgtcaatg gaagatttac tcaagaaact
     3001 tgatttcacc accaaacttc ctcggggcaa atgctcatgt ggaagactca ttagttgtag
     3061 acggatgttt cgttgatgga actgttaaac attctatcct ttcaacaggc gcgcaagttc
     3121 gcgaaggagc ggaagtcctt gattcagtta tcatgagtgg agctatcatt ggtcaaggag
     3181 ctaagattaa acgtgccatt attggtgaag gtgcgattat ttctgacggt gtcgaaattg
     3241 atggaacaga tgaagtacaa gttgtaggat ataatgaagt agtgggggta gcaacagatg
     3301 aagattgata aatattctgc cattttagga aatacagttg gttttcacga tatgtcgaca
     3361 ttgacggacc accgtccagt agcaagtttg ccatttgatg ggaaatatcg tttgattgac
     3421 ttcccacttt caagccttgc taatgcaggt gttcgtagtg tctttggtat tttccagcag
     3481 gataatatca gctcagtctt tgaccatatt cgttcagggc gcgagtgggg cttatcaacc
     3541 cttcttagcc attactatct aggaatttac aatacccgtg tagaaagtag tacagttgga
     3601 aaagaatact accaacagct tcttacttat ttgaaacgtt ctggctcaaa ccaaacggtt
     3661 gccctcaact gcgatgttct tattaacatt gatttgaacc aagttttcca cctacatagt
     3721 acaacaaaag agcctatcac tgtagtttat aaaaaactag ctaagaaaga tatttcagaa
     3781 gtaaatgcaa tcttggatgt agatgaaaca gaccatgttc tttctcataa actctttgat
     3841 agcaagtcaa cagctgaaac gttcaatatg tctacagata tctttgtcgt tgatacacct
     3901 tggttgattg aacacttgga agaagaagct aaaaaagaac atccagagaa attgcgctat
     3961 gttttacggg atttggctgt aaaagaggga gctttcgcct acgagtacac gggctatcta
     4021 gccaatattc actctgttaa atcttattat caagcgaata tcgatatgct tgaatcacaa
     4081 aaattctatt ctcttttctc accaaaccaa aagatttata caaaggtcaa aaacgaagag
     4141 ccaacttact atgctaatac atctaaggta agcacttctc agtttgcctc tggtagtatt
     4201 attgaaggtc aagtagctaa ttctgttcta tcacgtaata ttcatgtcca taaggatagc
     4261 ttggttaaag atagcctgct cttccctcgt gttgttattg gagaaggggc tcaggtcgaa
     4321 tatgctatct tggacaaagg ggttgaagtt gagcctggtg ttgtgattcg aggaactgca
     4381 gaacatccag ttgtggttaa gaaaggtgct aaagtaacag aggatattca ttcatgaaaa
     4441 ttttatttgt agcagcagag ggtgcaccct tttcaaaaac aggtggtttg ggagacgtca
     4501 ttggcgctct tccaaaatca ctggtaaaag ctgggcacga agttgcagtg attttaccct
     4561 actatgatat ggtagaggct aaatttggaa gtcagattga agatgtgctt cattttgagg
     4621 tgagcgttgg ttggcgcaga cagtattgtg gaattaagaa aacagtatta aatggtgtaa
     4681 ccttctactt tattgacaat caatattatt tcttccgtgg tcatgtttac ggtgattttg
     4741 atgacggaga acgctttgcc tttttccaac tggctgccat tgaggctatg gaaaggattg
     4801 actttattcc tgatcttctc catgttcatg actaccatac agctatgatt cctttcttgt
     4861 tgaaggaaaa ataccgttgg attcaagcct atgaggacat tgaaacagtt ttaaccattc
     4921 ataatttaga attccaagga caattttcag aaggaatgtt gggtgatttg tttggagttg
     4981 gctttgaacg ttacgctgat ggcacccttc gatggaacaa ctgtctgaac tggatgaagg
     5041 caggtattct ctatgcgaac cgtgtttcaa ccgtttcacc tagctatgct catgaaatta
     5101 tgactagtca gtttggatgt aatttggatc agattcttaa aatggaatct ggtaaagtat
     5161 ctggtatcgt gaatgggatt gatgctgatc tttataatcc tcagacggat gctcttttag
     5221 actatcattt caatcaggaa gatttgtctg ggaaagccaa aaataaggca aaattgcaag
     5281 aaagagttgg cttgcctgtt agagcagacg ttccactggt gggaattgtt tctcgtttga
     5341 cacgtcaaaa aggttttgat gtggtggtcg aaagtcttca ccatatcttg caagaagatg
     5401 ttcagattgt tcttttggga actggcgatc cagcctttga aggagctttc tcatggtttg
     5461 ctcagattta cccagacaaa ctatcaacaa atatcacttt tgatgtcaaa cttgctcagg
     5521 aaatctacgc tgcttgtgac ctcttcctca tgccaagtcg ttttgaaccg tgtggcttgt
     5581 ctcaaatgat ggctatgcgt tatggaacct tgccattggt ccatgaagtt ggaggcttgc
     5641 gagatacagt tcgcgctttc aatccaatcg aaggaagcgg tactggcttt agctttgaca
     5701 atctatctcc ttattggtta aattggactt tccaaacagc attggacttg tatagaaacc
     5761 atccagacat ttggagaaac ctacaaaaac aagctatgga gagtgacttc tcatgggata
     5821 cagcctgcaa gtcatacctt gacttgtacc atagtttagt taattaatag ataaaatcgt
     5881 atgatgactt catacgattt ttaggctgtt tagagaggag aactgatgtc tcaagtaaaa
     5941 ggcttgtgtg ttttggatgt agatggaacc ttaatcctag aagaagtgat tgatctttta
     6001 gggagagagg caggtcatga ggcggaaatt tcgcagatta caagtcgagc aatgcgagga
     6061 gagttggtct ttgaaagcag tttaagaaaa agagtgtcct tgttggaagg tcttcctatt
     6121 ttggtctttg ataacgtctt caactcaatt catctatcgc taaatgtccc agagttcatc
     6181 tctattctcc aaaaaaatgg catcctagtt ggtctggtgc ctggtggatt tacaccaata
     6241 gttggagaga ttagcaaaat cccttggtat tgcctatttc actgccaacc agcttgaagt
     6301 caaagaaggt cttttaacag gaaaattagt tggacaaatt ataagtcccc aggtcaaaaa
     6361 agaaactctg gaaaaatgga gaaagaaact aaaactttct aaagaaagaa cggtggcaat
     6421 cggtgatggg gtcaataatc tattaatgtt gaagtcggcg gagttaggaa tcgccttttg
     6481 ttccaaagaa atgctcaaaa aagaaatacc acatcatgtt gacaagaggg attttttaga
     6541 agttcttcct ttgattgact gtttagaatg agggaaaata tgaagattgt aattgcaccg
     6601 gattcgttta aggaaagctt gacagctcaa caggtagctg aagcaataaa aagaggcttc
     6661 caacaatcga tagcagatgt agaatgtctc ctctgccctg ttggtgatgg gggagaaggt
     6721 actgtagatg ctatccgaca ttctcttgac ctaaaagaaa aatggatcca agtgacagac
     6781 ccttttggac aaaaagaagc catgcgctat tttcaaaaag gggaactggc actatttgaa
     6841 gtagctgact tggttggtct tggaaaaatt ccgctagaga aacgaaaccc acttcaaatc
     6901 caaacttgtg gtattggaga gttgattctc catctcattt ctaaagggat taaagatatt
     6961 tatatcggtg ttggtggcac ggccagtaat gatggaggac tggggattgc tgctggttta
     7021 ggttatcaat tttatgatag ggatggaaat gtcttgcctg cttccggtca atccttatta
     7081 aacttagctt ctgtttcaac agaaaattgc tataaaattc ctgaaggtgt tcaaattcat
     7141 attttagcag atgtcgtgag tcccttatgt ggtcatcaag gtgcgactta cacttttggc
     7201 aatcaaaaag gtctacatcc gactatgttt gcagtcgtag atcaggcgat ccaagatttt
     7261 tatgaaaaat tctcacctgc aacattagaa attaaaggag caggagcagg tggaggcctt
     7321 gctggtggtt tgtgtgcctt tgctcaggca agtatcgtgt ctggaattga tacctgcttg
     7381 gacttaatca actttgataa gaaagtttca gatgctgact tggttgttgt tggagaagga
     7441 agacttgata gtcaaagctt tgctgggaaa gcgcctatag gtgttgcaaa aagaacccct
     7501 gttggagttc ctgttattgc tatttgcggt agtcttgctg aagatttacc tcccctacca
     7561 tttgaaaata tccaagctgt cttttctatt ttggagaaaa gtgaaccttt agaagatagt
     7621 ttgaaaaatg ccagtctcta tctggagcgc acggctgcca atattgggca cttattaaat
     7681 atgtgcaaga tttagctaaa ccatttcttc cataaggatg ttttggctgg ttcttccttt
     7741 ttaacttccc aaagttttgg aaaagcaagt cgaaggtctt tttcttctac ttgaactggt
     7801 gcattgctat gaataaccag gccaaaagga gaagtaatat gctcttcaga tactatggtg
     7861 gcttgactat cagtttcttt tgcttctttt aagtagaaaa cttgcttatc aaattcgata
     7921 gttggtgaaa tcttcacaaa tagtggctct gctttttcct gaaggttttc taaaataaat
     7981 aaaaagcctt tttctaactg agggctattt gctgtgtcaa tatctacata tccaagaact
     8041 ctttcctcaa aagtaccaag atagcgtctt tgctcatccg gatttatttt taacccacca
     8101 tgagcttttt caagtaattg ttttgataaa tctgtcatga aaacagtata tcataaaagt
     8161 tagaataaaa cagacaaaag aaagcgatta ctttataaag ttaaggaaaa gttgcacaaa
     8221 gataacgttt tttcttgaaa aaggaggggt tttaaggtat tatagaggtg taaaaaattt
     8281 aactcataag gagagtaaaa aatgtcaatt attactgatg tttacgctcg cgaagtccta
     8341 gactcacgcg gtaacccaac acttgaagta gaagtttaca ctgaatcagg tgctttcgga
     8401 cgtggtatgg ttccatcagg agcttctact ggtgaacacg aagcagttga acttcgcgac
     8461 ggtgacaaat ctcgttacgg tggtcttggt acacaaaaag ctgttgacaa cgtaaacaac
     8521 atcattgctg aagctatcat tggctacgat gtacgtgatc aacaagctat tgaccgtgct
     8581 atgatcgcac ttgacggtac tcctaacaaa ggtaaattgg gtgcgaatgc aatcctcggt
     8641 gtgtctatcg ctgtagctcg tgctgctgct gactaccttg aaatcccact ttacagctac
     8701 cttggtggat tcaacactaa agttcttcca actccaatga tgaacatcat caacggtggt
     8761 tctcactctg acgctccaat cgctttccaa gagttcatga tcttgccagt tggtgcgcca
     8821 acatttaaag aagcccttcg ttacggtgct gaaatcttcc acgctcttaa gaaaatcctt
     8881 aaatcacgtg gtttggaaac tgccgtaggt gacgaaggtg gattcgctcc tcgtttcgaa
     8941 ggaactgaag atggtgttga aactatcctt gctgcgattg aagctgctgg atatgtacca
     9001 ggtaaagacg tatttatcgg atttgactgt gcttcatcag aattctacga taaagaacgt
     9061 aaagtttacg actacactaa atttgaaggt gaaggtgctg ctgttcgcac atctgcagaa
     9121 caaatcgact accttgaaga attggttaac aaatacccaa tcatcactat tgaagatggt
     9181 atggatgaaa acgactggga tggttggaaa gctcttactg aacgtcttgg taagaaagta
     9241 caacttgttg gtgacgactt cttcgtaaca aacactgact accttgcacg tggtatccaa
     9301 gaaggtgctg ctaactcaat ccttatcaaa gttaaccaaa tcggtactct tactgaaact
     9361 tttgaagcta tcgaaatggc taaagaagct ggttacactg ctgttgtatc acaccgttca
     9421 ggtgaaactg aagattcaac aatcgctgat atcgcagttg caactaacgc aggacaaatc
     9481 aagactggtt cactttcacg tacagaccgt atcgctaaat acaaccaatt gcttcgtatc
     9541 gaagaccaac ttggtgaagt agcagaatac cgtggattga aatcattcta caaccttaaa
     9601 aaataaaata gttcagtgaa ctattttatc ccgaaccatg aaattcaaaa gttcggccgt
     9661 tgatttaaca acgtttctag cccctcggat tttatccgaa gggctatttt tgtatttaga
     9721 ggacaaaaaa gggacaaaac tttttaaaaa atctttttca taactttatc cagtacattg
     9781 attgcttcat ctttcatatt ctttgtgacg tgggtgtaga tggaagtagt gacttcagag
     9841 tcggaatgac caactctgtc cgtgattgtt tttaaaggaa ttttattttc tgataagatg
     9901 ctaatagtgg tgtgtctgaa gatgtgaggg gacagatgtt tgggaattgg ttttttaagg
     9961 cgttcgtttg ctcgctggag agacttgctc aagatagaac tatgaactgg ttttcctgta
    10021 ttggtaacaa aaatacggtc gcttttgtgc caattcttat cggttgtttc gcttagacaa
    10081 tttatatagt caattgaaac aagacaaaag agcctcgtaa aaggtattgc aacttggtaa
    10141 tacctttttg atatgaaccc atgttttctc aataggattg tactcaggtg aatagggagg
    10201 aagaggtaaa agtttatgcc caaactcttc acacaagagt tctagcttcc tcattctatg
    10261 gaatcttgca ttatccataa tatagtagat tgaaactaaa atagtacacc tctacttcta
    10321 aaacattgtt agaattcaat tttactgtcc tgatcgattt gtcctattct tatttcattt
    10381 tactataata accgatggtg tgtttaatgt tggtaagaga aacttctgaa accaagcttc
    10441 aaaaaagtcg ctcgtcatcg tctcttcgta agtcattgga gcgattaact caccattcat
    10501 ttgttagacc tgcaaccaaa gaaattctct gatatcttct tccagatact ttgcctcttc
    10561 ttaactgacc ttttaatgag cgaccatatt ctcgataaaa ataagtatcg aatcctgttt
    10621 cgtcaatcta aacaggtg
//
LOCUS       DAVHSO010000078        10117 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.079, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000078 DAVHSO010000000
VERSION     DAVHSO010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10117)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10117)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10117
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.079"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..221)
                     /locus_tag="VVR18_001989"
     CDS             complement(<1..221)
                     /locus_tag="VVR18_001989"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEU6033455.1"
                     /translation="MTLRTEDQVKDYAREVLGFNEVEENINQGTGQITTFNQLGFKGY
                     SDKPDGWYLPKNMNDVAIILETKSEERDI"
     gene            complement(225..443)
                     /locus_tag="VVR18_001990"
     CDS             complement(225..443)
                     /locus_tag="VVR18_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001207345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033456.1"
                     /translation="MALNYKPLWIQLAKKGLKKTDVIAMAGLTTNVMAQMGKDKPITF
                     KNLERICKALSCTPNDIISFEDNFSDEE"
     gene            complement(734..967)
                     /locus_tag="VVR18_001991"
     CDS             complement(734..967)
                     /locus_tag="VVR18_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit M"
                     /protein_id="HEU6033457.1"
                     /translation="MKKDKEVYDNVCEYLSPHLNKDMEVLELACWFRVIIVIEANSYV
                     NIRSSRLLPKFKTQKINSWCAAYSIHFNNGYCN"
     gene            complement(1181..1501)
                     /locus_tag="VVR18_001992"
                     /pseudo
     CDS             complement(1181..1501)
                     /locus_tag="VVR18_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000914584.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(1449..3250)
                     /locus_tag="VVR18_001993"
                     /pseudo
     CDS             complement(1449..3250)
                     /locus_tag="VVR18_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017767999.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
     gene            complement(3417..3569)
                     /locus_tag="VVR18_001994"
     CDS             complement(3417..3569)
                     /locus_tag="VVR18_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033458.1"
                     /translation="MTTNKDNDTSERSGCQRKRTAGEMPMNDLTSHTHGGNYTCYKEE
                     KVWNNQ"
     gene            complement(3700..3903)
                     /locus_tag="VVR18_001995"
     CDS             complement(3700..3903)
                     /locus_tag="VVR18_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000275922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033459.1"
                     /translation="MYIRLKNLREDKDLSQCQIAQYLHCSQSAYSRIESGKQDIPTSF
                     LKQLAKLYQVTTDYILEMDKFSC"
     gene            4405..5604
                     /locus_tag="VVR18_001996"
                     /pseudo
     CDS             4405..5604
                     /locus_tag="VVR18_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713014.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            complement(5983..6768)
                     /locus_tag="VVR18_001997"
     CDS             complement(5983..6768)
                     /locus_tag="VVR18_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033460.1"
                     /translation="MKKYQRMHLIFIRQYLKQIMEYKADFLVGVVGVFLTQGLNMLFL
                     NILFQHIPLLDGWSFHQVAFIYGFSLIPKGIDHLFFDNLWALGQHLIRKGEFDKYLTR
                     PISPLFHILVETFQIDALGELLVGVLLLLMTITSLTWTWAKVFLFLISIPFATLIYTS
                     LKIVTASIAFWTKQSGAIIYIFYMFNDFAKYPIAIYHSFLRWLISFIIPFAFTAYYPA
                     SYFLKDKDGLFNIGGLILISLIFFTLSLKLWNKGLDAYESAGS"
     gene            complement(6770..7589)
                     /locus_tag="VVR18_001998"
                     /pseudo
     CDS             complement(6770..7589)
                     /locus_tag="VVR18_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
     gene            complement(7591..8583)
                     /locus_tag="VVR18_001999"
     CDS             complement(7591..8583)
                     /locus_tag="VVR18_001999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6033461.1"
                     /translation="MKMITVEHLQKNFVKTIKEPGLKGAFRSFFHPKRQVFEAVKDLS
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQENRQGYVKDIGVV
                     FGQRTQLWWDLALQETYSVLKEIYDVPDAVFQKRMDFLNEVLDLKEFIQDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLG
                     DIEQLCDRIFMIDKGREIFDGTVNQLKKTFGKMKTLSFELHPGQDYIVSHFEGLSDIY
                     VTRQELSLDIQYDSSQYQTADIIQQTLSDFTIRDLKMTDANIEDIIRRFYRKEL"
     gene            complement(9600..10097)
                     /locus_tag="VVR18_002000"
     CDS             complement(9600..10097)
                     /locus_tag="VVR18_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase"
                     /protein_id="HEU6033462.1"
                     /translation="MTEFPIEFFNKSDAGFQHMIKTYDQMINQKQSKLGYKKFFKLLL
                     SHPKDESLLFHCSMGKDRTGIASLFLLYILGVDMNDIFHDYLLSNKYLINVRKENIEY
                     VNNHSGNVILMHNLLSLSSAKEEYINRVLNVLDKEYGGILRYINTELGISSQEIEELK
                     DRYLF"
BASE COUNT         3315 a         1947 c         1442 g         3413 t
ORIGIN      
        1 ctaatatctc tttcttctga ttttgtttca aggattattg ctacatcatt catattttta
       61 ggtaaatacc aaccatctgg cttatctgaa tatcccttga agcctaattg attaaaagta
      121 gttatttgac cagtaccttg attgatgttt tcttcaactt cattaaagcc taatacttct
      181 cttgcataat ccttaacttg atcttctgtc cttaaagtca ttttctattc ctcgtcacta
      241 aaattatctt caaaactaat aatatcatta ggagtgcaag ataaagcctt acatattctt
      301 tctaaattct taaatgtaat tggtttatcc tttcccattt gtgccataac atttgttgta
      361 agtcctgcca tagctattac atctgttttc tttagtcctt tttttgctaa ctgtatccat
      421 aatggtttat agttaagtgc cataatatcc ctcttttttt cttcattaga tttatttaat
      481 tatagcataa atattgattt cattcaatct tacattgatt tagtgatttg ttttagagaa
      541 tttgttgtgt tattccgtcc ttattttgcc ataaattgtt ttaagtggga cctcttatcc
      601 ttaccatttt tacctcctaa ttttgagtat aaaaaagacg atagagtttt taatttctat
      661 cgtctgagat ttacatatta aattttcatc acaaaataag actctttaaa gaatctttaa
      721 attcattggt atgctaatta caatatccat tattaaaatg gatactataa gcagcacacc
      781 aactatttat tttttgagtt ttaaactttg gtagaagtct tgaactcctt atatttacat
      841 aactatttgc ctctataact attatgacac gaaaccaaca agcaagttca agcacctcca
      901 tatctttatt caaatgagga ctaagatatt cacaaacatt atcataaacc tctttatctt
      961 ttttcataaa agaggcatac aacttagcaa atttatccta aaattttttg ttgcctttat
     1021 caatcatttc aacgctcctt taaatataaa aatgatccta tcaatcttta tattgagcct
     1081 attttctaat tgataccttg caagaaagga ataatagctg ttcctatacc aagtaggaat
     1141 gtaataaatg cagaaagtca tatactgtca ttcttttcta ttaaatcatt ttgaagtgtc
     1201 tcaaagcatc catgatggct tcttcttttt caggtgtaca ctgtggaata atttgtttat
     1261 cctttttaga cttgttgtaa tgttttcgta attctattcc acatttcttt tttatctgtg
     1321 caatatataa tgtcgaaact tttaattcaa atttattcca aacatattct ttgatttgag
     1381 catatgttgc tttgctctcc gcacttgtca aatccatctc atccagctca atttcaacac
     1441 ttatatgctt atcgacatcg agtttggaca aaagtgctac cgtctcgacg tgtgttgtct
     1501 gtcccttgag aatacaattt tttatcctcg tcactgtttt gaggacacaa tttatctggt
     1561 tctagtttag catttttacg tttactttta aattttttac catccttgtt ttgagtttca
     1621 cctgttttga atattatggt taacattgca ggatcaattt ctccgtcgat attaacacca
     1681 cctacaataa ttttctcaac aatactttca aaaactgtac gatcaaactc cgtaagcatt
     1741 ttctgtgaag atagcaagtg cttaaactca gttagtcttt tctttacatc gatttctgat
     1801 tttaatgttg tttcaatatt taccttctct tctgctagaa actctttttc tgaggaaatt
     1861 tcattgtact tttcattgta tatggaatcg ctaacttttc cttcgagcct tagatttaca
     1921 agattctcct ctttttttag taatattcga agtttgtttg taatcctttt tagttccttg
     1981 ttaaggctat tgtcattcaa ttcagattct atcgtttcaa gtaagtctgt cattaaattt
     2041 tcatttgaat gatagacttg tctgtaagct tccaggaaag ccccctcaat ggcgatctct
     2101 tctaatcctt tactatgctt acaaaatttc tttcctttct ttatcgattc tttatcgatg
     2161 taacacagtg ccacacaact ttgcgataat ctgaacggca gtgccaactt cttctagata
     2221 atattgaacc acaaaaacca cattccaaca tgctactaaa agcatacatt tttgaatagc
     2281 gttcacgctt cccatttaca ttcgcagctg tcttcttatt tcctgctcga cgcaatctaa
     2341 tctcctgagc tttttcaaaa tcttctttag atattattgg ttcatgatta tccttgatat
     2401 agtacttatc ttcttctcca aaattactca accgtctctt gcttattggg tcaactgtaa
     2461 aagtttttcc cattagaata tcacctttat atttttcatt ctttattatt cctagaactg
     2521 ttgtatcatt ccagtgttct aaacctcttg gcgatttgta accaagttca tcaagttccc
     2581 ttgcaattac ttttcctcca ataccttcta gatacctttc aaaaatataa cgaacaattt
     2641 tggcttcttt tttattaatt gaaatctgct tggtttctac atcataatca taccctaagc
     2701 acccttgaaa accaaccaat tcaccacgtt gcatcttcat ttttaatcct tttttcacat
     2761 gggcagaagt attctctact tcttgctgtg caacggagct tagaatagtt agaagcaatt
     2821 ctccatccat tgttagggta tctatgtttt cttcctcaaa atatactcca atttgcatat
     2881 cctttaacat tctgacatac ttcaaagtat ctagggtatt ccttgcaaat ctagcaattg
     2941 cttttgtgac aatataatct atctctccat ttgcacaatc attgattaat cgttgaaaat
     3001 cttgtctctt tcctacttgt gttcctgaaa taccttcatc tgcataaata tctgccagct
     3061 cccaatctga acgctgagaa atatattctt tgtagtgtct tacttgagaa tcataactgt
     3121 ttttctgatc ctcactatcg gaactaactc tgcaataagc agcaaccctc tttaagtgtc
     3181 tttctacatt gtcgcctctt cgacgaacta aagaatcagc ttttattatt tcaacattat
     3241 tttttttcat actgaaattc ctccttttga ttctatatta ccgcattcaa atcaaaaagt
     3301 cagctatttt gtgtacttaa tacgcagttt gtttctaatc ttgtcatact catttttaga
     3361 taacatattt cttgagtata aaaagttaag cattgatagt tgcatagtat actttattac
     3421 tgattgttcc aaactttttc ctccttgtaa catgtataat ttcctccgtg ggtatgactg
     3481 gttaaatcat tcatgggcat ttcacccgct gtcctttttc gctggcagcc tgaacgttca
     3541 gaagtatcat tatccttatt tgtagtcatg gcagatagag aaccactcta ttttatagct
     3601 aataattatc gctcctatca cggcgtatca agctaaagtg ctcgacaaat aagaaagtcc
     3661 cacctcggtt tattcagttt tcaaagggct taggatttat taacaactaa acttatccat
     3721 ctctaaaata taatctgtag ttacctgata taatttagct aattgtttca aaaatgatgt
     3781 aggaatatct tgcttgccac tttctattct agaataagca gactgtgaac aatgaagata
     3841 ctgtgcaatt tgacactggg acaaatcttt gtcttctctt aaattcttta atctgatata
     3901 cattaataat cctcttacta atattgtaat ttgaagatta tcaaatttgg aattttatgc
     3961 aaaatatgca taaaataatt tataagattt tagaaatagt tggtataaca gtaagtaagc
     4021 tataagttac taaaaaaaga ttttggaata aactttttca tagcgataaa agcaccgtac
     4081 aagctaggaa aataataagt aatcgcccaa tctgaccttc tccagaactt gattattcgt
     4141 caatcactac agttgacaaa catactaaga ttagtagtga ggaaatctcc aacgggagag
     4201 agtactcatt actttttctt tgtgttaaaa tagtggtgtc ttgttaagtc atagagctct
     4261 ctatggtgct agacgtcgct tgacaaactg gcaagaaacc tgttttagga agaattttat
     4321 caaagtatgt gggatactag acgtcgagta ttggaaataa aatcactaaa acaaggagtc
     4381 attcaagaca aaggggtaaa catgatgcgg acagttttca gaatggatgt gagtaaggca
     4441 agctcagaag tcgctattct tgtgaatggt gaaaaggttc atggctatac catgcccaat
     4501 gatgccatcg gatttagtcg tcttctagag gatttgaaat aggtaaatac acctgagatt
     4561 atcttcgagg cacagacagg ggtctattct cgtcttcagg cctttctgga ggacaatagc
     4621 tatgcttata tacggctaaa tcctttaaaa ctaagaagca actagacagt ttgcgagtcc
     4681 gtaaaaccaa tcagattgac gctgaaaagc tagcttcgtc acaattcatc cttaaccgca
     4741 aaccaactta tgttcaagaa gaagtctatc aaaatttgcg tgacctcagt cgattctatc
     4801 agaatctgac agaagacatc gttaggacta agaatagcct gcacaaggtg cttcaaattg
     4861 cctttccaga aataaagaac cttctctcta ctcctacagg ggaacaatat tggaacctcg
     4921 tgaccatctt tccaaccaag cattggaggc tgaaattatc agtagttgag ctaaaagaag
     4981 ccatcgtaat tcaacttcta aacggatttc tgagaacaga gttggacgat tggctgaaaa
     5041 gttgagcgag ctggccgaac agtcctatct tgccatttca aaaacctctc ccatgacaga
     5101 agaggttaag tatcatgcac aggaactgtt gagactgaca aaccgcaagg atcaggactt
     5161 agcacaaatg attgaattgg ctgaaccatt acctgaatac gagattctgc tctctattcc
     5221 tggtatcgca gaaacaacag ctacaagcat tattggcgaa ttggagacat tcgtcgcttt
     5281 cagtctgcca accaaatcaa tgcctttatc agtattgacc tcagacacta tgaatctggc
     5341 aatttcctag ctcaagaaca tatcaccaag cgtggaaatc cttacgcgag aaaaattctc
     5401 tataagtgcg tccacaatat tgcttcagct agtcatacca atccttgtca tatcgcggac
     5461 ttttatgaga aacgaaaaag acaatcgcag acgacttcaa ccaagccata tacgattgtc
     5521 tctatacatc gcctcatccg gacaatgtat tacctcataa cgcataacaa actttacgac
     5581 tacactttaa cccaaagtca ttaaagtcat ctatgtccta tcattgtaac accttatttt
     5641 ttaataccag ataagtgtct tttaagtgtg cccaaatttc aaaaaacagc tcgcaattat
     5701 cttctaaaca ttcctttgat actcattcag aaaacctttt gagctagaat atcgtatgtc
     5761 ccttaacaaa tggtatgtat aaaagagcta aaaaaccact catgatatga acgagtggtt
     5821 atgactgaaa tattacatac ctttgtatca tttttgcaca atggtcaaat ttcttgtttg
     5881 aaaaactaca gtaagcctaa tcaaagctct caatgtatca ttaaaacttc cttccaaaga
     5941 ataggaagtt ctatcaaaat tcttaattag attttacttc ttctaagacc ctgcgctctc
     6001 atatgcatcc aaacctttgt tccataattt taatgataag gtaaaaaata ttaatgagat
     6061 aaggatcaat ccaccaatat tgaacaatcc atccttgtct ttcaagaaat agctagctgg
     6121 gtaataggct gtaaaagcaa aaggaatgat aaaactaatc aaccaacgta aaaacgaatg
     6181 gtaaatcgca atcgggtatt ttgcaaaatc attaaacatg taaaaaatat aaattattgc
     6241 cccagattgt ttagtccaaa aagcaatact agctgttaca atttttaaag aggtataaat
     6301 taaggttgca aagggaatac tgattaaaaa gagaaaaacc tttgcccaag tccaagtaag
     6361 actagttatt gtcattaaca gcaataagac gcctactaac aattctccaa gagcatcaat
     6421 ttgaaacgtt tctactaaaa tatgaaacaa agggctaatg ggtctagtca aatacttatc
     6481 aaattctcct ttacgaatta aatgttgtcc taaagcccac agattatcaa aaaagagatg
     6541 gtcaattccc ttaggaatga gagaaaaacc ataaataaaa gcaacctgat gaaaactcca
     6601 gccatcaagt aagggaatat gttgaaacaa aatatttaga aacagcatgt ttaacccttg
     6661 tgtcaaaaag acacccacaa caccaactaa aaaatcagcc ttatactcca taatctgttt
     6721 aagatattgt cggataaaaa tcaggtgcat gcgttgatat ttcttcattc taacctcctt
     6781 gaatagttat ataattctgt acgcacttcc aaatcagttg ggataaggca atcataataa
     6841 acagccagaa taattgtagc gagagcgcct gaatcatttg actcatgcta tacttttcta
     6901 taataaccat caccggggta tagattaaag aagaaaatgg caaaaaagat aatagttcgg
     6961 caataatttt tggaaaaaat gtcagaggaa ccaaacttcc agataaaaag gcaactaaag
     7021 aatttttcaa aagatttgat ccccataagt ttttaaacac aaaagctgaa aaaccaaagc
     7081 aaatattgaa aaaaaaaatt aatcaaaaaa gctaagatta agctaagaag gtaaactgtg
     7141 gttattaaaa caatttgtaa gaaggactca cctgataaga gctttagacc tgcaatcaga
     7201 attacaaatg gtagaccaac actaacaaaa actagccatc tagacccaat ttctgtgaaa
     7261 agataagaca ttgcaaaatg aactggacga agcagtcgca taataataga gccatccttt
     7321 acttcccatc caatcataaa agaactatct gattttgtca gtagattcgt cacaaaactc
     7381 atgatgatat ataaggtcat atcagataaa gtaaaacctt gaatgagaga ctggtgagat
     7441 gaatcaaaca cagctttcca caagtaaaat gctacaaagg cccccatcac atccccaatg
     7501 cgataaagaa aaaaattgac acgatacgtg attaattctt ggattccagc gctaacaaaa
     7561 ggcttatagc gtttccataa tttagtcatc ctaaagctcc tttcgataga agcgacgaat
     7621 aatatcttca atattcgcat ccgtcatctt taaatcacgg atcgtaaaat cagacaaagt
     7681 ttgttgaata atgtcagccg tttgatactg cgagctgtcg tactgaatat caagtgacaa
     7741 ttcctgtctc gtcacataga tatcagaaag tccttcaaaa tgagagacaa tataatcctg
     7801 cccaggatgt agttcaaaag agagagtctt catcttcccg aaagtctttt tcagttgatt
     7861 cacagttcca tcaaagattt ctcggccctt atcaatcata aaaatacgat cacataactg
     7921 ttcaatatca cctaaatcgt gggtcgttaa aagtatggtc gtctcttctt cttgattaat
     7981 ctgtgtaatg gcacgtcgaa tattatcctt gaccgaaaca tctaaaccaa tagtaggctc
     8041 atctaggaaa agaactttcg gattatgcaa taaggaggcc gcaatatccg ccctcatacg
     8101 ttgacctaga gatagagttc tgacaggatc ttgaataaat tccttcaaat ctaaaacttc
     8161 atttagaaaa tccatgcgtt tttgaaagac cgcatcagga acatcataaa tttcctttaa
     8221 aaccgagtaa gtctcctgca aagccaaatc ccaccaaagt tgagttcgct gcccaaaaac
     8281 tacaccaata tctttaacat agccttgacg gttctcttga ggaatctttc cattgatacg
     8341 acaaaaacct gatgttggtt tcaaaatccc cgtcaacatc ttgatagttg ttgatttccc
     8401 cgctccattt gcgccaataa agcctaaaat ttgtcctttg ggcacctcaa atgataaatc
     8461 tttaacagct tcaaagactt gtctcttggg atgaaaaaaa gagcgaaaag ctccctttaa
     8521 gccaggttcc tttattgttt tcacaaaatt tttctgaaga tgctctactg ttatcatttt
     8581 tataaatcac tcctttcgtt tcactcaagt tataatatca acaaaaattg tagcatacta
     8641 cagtaaagtt aagaaaattt accatcatta caaaccatat gaaaaaagct actaaaacta
     8701 tgccatcttg tattttatct gtaagtaagc taaattactc aagtacaaag aattatgacg
     8761 aagaacatat aaatttataa ttggataaac tatagatttc agcaaacgaa gttatcccaa
     8821 tataaaaata ctttaataac tgaagatatt gacaggaaga tattaaattc ctcattacta
     8881 tcctttacta tgcagtataa ttttaatatc atttacctac ttccaagatg ctgaaaaata
     8941 ctaagtcaca ctattatgat gttattattt ccatttttat tttaacagat gagtcaattc
     9001 tttcaactac cccctccctt ataactatat tcatgaagta ttcttgataa taaacctcat
     9061 ttaacttctc aaagtagtca gcttctgcaa ctgctattat ctcataacag attgatttgg
     9121 tttcaataaa tggaagctag aagccttgtc agctaccctg cacagttggt gttttttcat
     9181 ttttctcttc aaaaaaattg gtcggaagtt ataataaaaa ggtgatgtgt ttgtggtgag
     9241 ttgaattaag agacaaactc actttgtctt aacttttaaa ttgcctaaca aaaatacgga
     9301 gattattctc taagctttaa ctgcaacatt atgtctctac aaccaacgat aagtccagaa
     9361 atctacccaa ataaccaaac aacctacatt tgttgaactt tgatgacaag taggaaattt
     9421 tacatttgat aaacactatt ttgtacgcat tttgcacata atttaacgtg ctttccatca
     9481 atttagttaa ggacttacat agaaaacaat ccgtttttgc ttatgttaaa ttagtagaat
     9541 tagacaaaaa caaaaccgcc attcgcactg ttatatattc atttttagta cttactattc
     9601 taaaaaagat atctatcttt caattcctca atttcttgac tacttattcc tagttctgta
     9661 ttaatatatc taagtattcc tccatattct ttatcaagga cattcaatac tcgattaata
     9721 tattcttctt ttgctgaact gagtgaaagt aaattatgca tcaatattac attcccacta
     9781 tggttattta catattcaat attttctttt ctcacattta ttaaatactt gttagatagt
     9841 aagtaatcat gaaaaatatc gttcatatct actcccaata tataaagcaa gaacaagcta
     9901 gctattcctg ttcgatcctt ccccattgaa caatgaaaca aaagagattc atcttttgga
     9961 tgacttagta ataatttaaa gaatttcttg taaccaagtt tactctgttt ttgattgatc
    10021 atttgatcat aagtttttat catatgttga aaacctgcat ctgatttgtt aaaaaattct
    10081 attgggaatt ctgtcaactc tgaatcatca ttataga
//
LOCUS       DAVHSO010000079         9911 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.080, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000079 DAVHSO010000000
VERSION     DAVHSO010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9911)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9911)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9911
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.080"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            18..1241
                     /locus_tag="VVR18_002001"
     CDS             18..1241
                     /locus_tag="VVR18_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HEU6033463.1"
                     /translation="MITKQSAFLQNRATILEFLYRNPATSRTDIVNETGLTPATTTNI
                     IKELSEQSLIYETGDEFSEFSGSGRRRKTISITDNIPYVVGGIEINVLGIFLSLCDLQ
                     GKTLFETEILNEDYPISEINSTITNMIKTAIEYVPLETKLLGFGLSIPGHYNKDSGSI
                     ITNNPIWESFNLLNVIKDFNFPFIVKNNIDCMAIGQYLFNPHNTPDNFIFLHAGLGIY
                     TSFFTKEKIGASKNPYIGEIGHTIVELNGQYCECGKKGCLQTYISDAWLIKHAQLLFK
                     NSQLTVLKSLVKTEKDIHLDTLLTAYNLGDSALRQQIDKGVNLLATSIANLLLINPAD
                     KIYINSQLLNYQPFTHEVRDKIQDQLHFVPFTRNIEIEILPYNKHRGSIGACALAIVA
                     FFIEHSNVLQDIISP"
     gene            1901..2071
                     /locus_tag="VVR18_002002"
     CDS             1901..2071
                     /locus_tag="VVR18_002002"
                     /inference="COORDINATES: protein motif:HMM:NF024172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033464.1"
                     /translation="MTKQVPKFTKDTAQLYTCKWLLYNKVTKMYDHTVVNHSVREYIT
                     DSISTNTIEEAG"
     gene            2684..2968
                     /locus_tag="VVR18_002003"
     CDS             2684..2968
                     /locus_tag="VVR18_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002923859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033465.1"
                     /translation="MDWYDYMIQASKQSQFNASHWFRYLRKVIFEDYSYLTNQDVEKL
                     LDSKELTRFQKISLKYAFQEHTPTHKYVISLNKPAKLTNVQKLMEKYKHG"
     gene            2961..3518
                     /locus_tag="VVR18_002004"
     CDS             2961..3518
                     /locus_tag="VVR18_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002923862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium transporter peripheral membrane
                     component"
                     /protein_id="HEU6033466.1"
                     /translation="MDKMKPVFQALNKELIQENLTLTIICVDGYVLEYHGLRATQDVD
                     AFYDQNQKINEIIARVGKQFNLNTHEELWLNNHVANMNKQPPLSLCESLYSFENLTVL
                     VVPIEYVLGMKMMSIREQDLKDIGAIIKYKNFHSPFDTFKYLKDMGFDTIDLSVLLEG
                     FSYAYGMDWLEKFFKENQDKLREFY"
     gene            complement(3885..6209)
                     /gene="pflB"
                     /locus_tag="VVR18_002005"
     CDS             complement(3885..6209)
                     /gene="pflB"
                     /locus_tag="VVR18_002005"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HEU6033467.1"
                     /translation="MVVKTVVEAQDIFDKAWEGFKGVDWKEKASVSRFVQANYTPYDG
                     DESFLAGPTERSLHIKKIVEETKAHYEETRFPMDTRPTSIADIPAGFIDKENEVIFGI
                     QNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIR
                     RARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAIKEIDEETIRLRE
                     EVNLQYQALQQVVRLGDLYGVDVRKPAMNVKEAIQWVNIAFMAVCRVINGAATSLGRV
                     PIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDQLYSGDPTFITTS
                     MAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDKLPYNFRRYCMHMSHKHS
                     SIQYEGVTTMAKDGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNG
                     GYDDVHKDYKVFDIDPIRDEVLEFESVKANFEKSLDWLTDTYVDALNIIHYMTDKYNY
                     EAVQMAFLPTKQRANMGFGICGFANTVDTLSAIKYATVKPIRDEDGYIYDYETIGDYP
                     RWGEDDPRSNELAEWLIEAYTTRLRSHKLYKDAEATVSLLTITSNVAYSKQTGNSPVH
                     KGVYLNEDGSVNLSKLEFFSPGANPSNKAKGGWLQNLNSLSSLDFSYAADGISLTTQV
                     SPRALGKTRDEQVDNLVTILDGYFENGGQHVNLNVMDLNDVYKKIMSGEDVIVRISGY
                     CVNTKYLTPEQKTELTQRVFHEVLSMDDALDALS"
     gene            6603..7664
                     /gene="dinB"
                     /locus_tag="VVR18_002006"
     CDS             6603..7664
                     /gene="dinB"
                     /locus_tag="VVR18_002006"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HEU6033468.1"
                     /translation="MLIFPLLNDLSRKIIHIDMDAFFAAVEIKDNPKLRGKPVIIGSD
                     PRQTGGRGVVSTCSYEARAFGVHSAMSSKEAYERCPQAVFISGNYEKYKAVGLQIRAI
                     FKRYTDLIEPMSIDEAYLDVTENKLGIKSAVKIARLIQKDIWQELHLTASAGVSYNKF
                     LAKMASDYQKPHGLTVILPEQAEDFLKQMDISKFHGVGKKTVERLHQMGVFTGADLLE
                     VPEVTLIDRFGRLGYDLYRKARGIHNSPVKSNRIRKSIGKEKTYGKILRAEEDIKKEL
                     TLLSEKVALNLHQQEKAGKIVILKIRYEDFSTLTKRKSLAQKTQDASQISQIALQLYE
                     ELSEKERGVRLLGITLTGF"
     gene            complement(7811..8656)
                     /locus_tag="VVR18_002007"
     CDS             complement(7811..8656)
                     /locus_tag="VVR18_002007"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HEU6033469.1"
                     /translation="MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNE
                     AFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGV
                     FKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYI
                     GLFQVLALLPGTSRSGATIVGGLLNRTSRSVVTEFTFYLGIPVMFGASALKIFKFVKA
                     GELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSF
                     VRLFV"
     gene            8912..9780
                     /locus_tag="VVR18_002008"
                     /pseudo
     CDS             8912..9780
                     /locus_tag="VVR18_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841243.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         3263 a         1896 c         1788 g         2964 t
ORIGIN      
        1 accaaaggag gaaacaaatg attacaaaac aatcagcctt tttacaaaat agagccacta
       61 tactggagtt tctatatcga aatccagcaa catctcgtac agatattgtt aatgaaacag
      121 gacttactcc agcaacaacg actaacatca tcaaagagct aagtgaacag tccctcatat
      181 acgaaactgg tgatgaattt agcgagtttt ccggatctgg aagacgtaga aaaactattt
      241 ctattacaga taatatccca tatgttgttg gaggtattga aataaacgtc ctaggtatct
      301 ttctcagtct atgtgactta caagggaaaa ctcttttcga gacagaaatt ttgaatgaag
      361 attatcctat ttcagaaatc aattccacca ttaccaatat gataaaaaca gctatagagt
      421 atgtcccttt ggagacaaaa ttacttggat ttggcttatc aatacctgga cattataaca
      481 aagactccgg aagcatcatt acaaacaacc ccatatggga atcttttaat ttattaaatg
      541 taattaaaga tttcaatttt ccttttattg taaaaaataa tatcgattgt atggctatag
      601 gacaatacct ttttaatcca cacaataccc ccgataactt tattttccta cacgctggat
      661 taggtattta cacttccttt ttcacaaaag aaaaaatagg agcctctaaa aatccttata
      721 tcggagaaat tggacacacc attgtcgaat tgaatgggca atattgtgaa tgcggaaaaa
      781 aaggttgttt acaaacatat atttcggatg cttggttaat caaacacgcc caattattat
      841 ttaaaaattc ccaactaact gtactaaaaa gccttgtaaa gactgaaaaa gacattcatt
      901 tagacaccct tttaacggct tataatttag gcgactccgc tttacgccaa caaattgata
      961 aaggagtcaa tttattggcc acttctattg caaatcttct cctcatcaat cctgctgata
     1021 aaatctatat caacagtcaa ttgcttaatt atcaaccttt cactcatgaa gtcagggata
     1081 aaatccaaga ccagctccac ttcgttccct ttactcgtaa tatagaaatt gaaattttac
     1141 cttacaacaa acatcgtgga agtataggag cttgtgcatt agctatcgtt gcttttttca
     1201 tagagcatag caatgtatta caagatatta tttcacctta atatatatta gaaatctata
     1261 cacctgttta aatcaactat aacctgtagt aaatatctcg tatttagaca atatgaaaac
     1321 aagacgactt ccatatagga aaccgccttc tctctatgtt gagtgattta tattaaaata
     1381 acttttcttc tagctgcatt ttattattat aaaaacattc atcataaccc ccagaactta
     1441 aataacaatt tttattcaag atacatactc ctagaataaa ctttatatga aatccccatt
     1501 tttgttttta caattctcct tagttaaatc ttgtttaata tatgttttac atatagtatt
     1561 tagcgccaca tagtactgaa ctctctccaa aaacggttat tcctctttga atagggcgtt
     1621 atcacaagaa aagcatctcc acgtttcaac ttcatatggc tcaaaaacaa ttaattgatg
     1681 ctaaaacctg tacctagatg tttcggttca taaaaccatg aaactgtaaa agtggatgaa
     1741 attgatagtg atagtcaaat caagagacat cataactcta aaaagtcaca atatataagt
     1801 tcatcctcgg aaaaatatca ttctaattgt tgaaatggat atataaacag gggtattaac
     1861 attaaatgct catgaaacaa cgaatacagg tatcaaaact atgacaaaac aagtccctaa
     1921 atttactaaa gacactgctc aactttacac ctgtaaatgg ttgttgtata ataaagttac
     1981 aaagatgtac gaccacactg ttgtaaatca tagtgttcgc gaatatatta ctgatagcat
     2041 ttctacaaat acaattgaag aggctggata ggctttaaac gaaatatgtc agtgttttgg
     2101 cattcctagc cttaatatca tttaaagaat tgtatagata aaattttttc caatacagac
     2161 actcgtaaca actgcttcat ttttctacca acatatttag gaacaggata agatacaaga
     2221 ggattaatcc ataaatcagt tctataccaa tctaagacaa ataagctaaa aaaaacgatt
     2281 gataataagc aaatagattc caaattttct ctatcggctc attttaataa acaatactag
     2341 tgtaactatc cttccagtca gaaacttgtc aaatcacacc gaaaattctt ctaaaattta
     2401 tctcgttagg caatcaagca aaaactcgac gatagtacaa acattatcat acaggattga
     2461 cttcctaaat tatatacttt agtaaggttt tcggataaga aaaaaggttc attttacatt
     2521 tctaaacatt cttttctaag atgaaaaaca gaatttttcg attgtgattt aaagcaacaa
     2581 gaagattttc agtatcatcc tatagatccg agctaattaa gaaaaactac atttttgaat
     2641 ataaactaca ataatataaa ctaaatttca taggaggaag acaatggatt ggtacgatta
     2701 tatgatacag gcatccaaac aatcacaatt caacgcaagc cattggtttc gctatttgcg
     2761 aaaagttatt tttgaagact attcttattt aacaaaccaa gatgtagaaa agttgctaga
     2821 ctccaaagaa ctaacccgtt ttcaaaaaat tagcttgaag tatgcctttc aagagcatac
     2881 tccaactcat aaatatgtga tttcattaaa taaacctgct aagttaacca atgttcaaaa
     2941 attgatggag aaatacaaac atggataaaa tgaaaccggt cttccaagcc ctaaataagg
     3001 aattaattca ggaaaatctg actttaacaa ttatctgtgt cgatggttat gtcttagaat
     3061 atcatggttt acgtgccaca caagatgttg atgcttttta tgaccaaaat cagaaaatca
     3121 atgaaattat tgctcgtgta ggaaaacagt ttaatcttaa cacccacgaa gagttatggc
     3181 tcaacaatca tgttgcaaat atgaacaaac aacctccctt aagtttatgc gaatccttgt
     3241 actcatttga gaatctgacc gttttagtag tccctattga gtatgtgtta ggaatgaaga
     3301 tgatgagtat cagagagcag gatttgaaag atattggtgc aattattaaa tacaaaaact
     3361 ttcattcacc attcgatacc tttaaatatt taaaagacat gggatttgat actattgacc
     3421 tctctgttct attagaaggt tttagttatg cttatggtat ggattggtta gaaaaatttt
     3481 ttaaagaaaa tcaagataaa cttcgcgaat tttattaaca gtatcaaaca agatgattgt
     3541 caattagcca gtcgtcttat ttttatgatg gaatgaaata aaatcggaac aaatcactta
     3601 gagaattcca gtcaatttct agcactgttt gagacgtttc agcggactat agtaaaatga
     3661 aataagaata ggacaaatcg atcaggacag tcaaatcgat ttctaagaat gttttagaag
     3721 taaaggtgta ctattctagt ttcaatctat tatatttcag attcggtcca ctattccttc
     3781 ccaaaaacat tgcatattgc gccgaaggaa ttgctcacac tatcccaagc acaaaaccct
     3841 cagtcgattg accgagggtt cctttttatt attcaagaac ttgattagct caatgcatcc
     3901 aaggcatcat ccattgaaag aacttcgtgg aagacacgtt gtgtcaattc agttttttgt
     3961 tctggagtga ggtatttagt gtttacacag tatccagaga tacgtacgat aacgtcttcg
     4021 cctgacatga tctttttgta aacatcgttc aagtccataa cgttcaagtt aacgtgttgt
     4081 ccaccgtttt caaagtaacc atcaaggatt gttaccaagt tatcaacttg ttcatcacga
     4141 gtcttaccaa gagcgcgagg tgatacttgt gtagtcaatg agataccgtc agctgcataa
     4201 ctaaagtcaa ggctagaaag tgagttcaag ttttgcaacc aaccaccttt agctttgtta
     4261 gatgggttag cacctggtga gaagaattca agtttagaca agttcacaga accatcttcg
     4321 ttgaggtata cacctttgtg aactggtgag ttaccagttt gtttagagta agcaacgtta
     4381 gatgtgattg tcaaaagtga tactgtagct tctgcgtctt tgtatagttt gtggctacgt
     4441 agacgagttg tgtaagcttc gatcaaccat tctgccaatt cgtttgaacg tgggtcatct
     4501 tcaccccagc gtgggtagtc accgattgtt tcgtaatcgt agatgtagcc atcttcatca
     4561 cggattggtt taactgtagc gtatttaatc gctgacaatg tatcaacagt gttagcaaat
     4621 ccacaaatac cgaatcccat gttggcacgt tgtttagttg gcaagaaggc catttgaaca
     4681 gcttcgtagt tgtacttatc agtcatgtag tggatgatgt tcaaggcatc tacgtaagtg
     4741 tcagtcaacc agtcaagaga tttttcaaag ttcgctttaa ctgattcgaa ttcaagaact
     4801 tcgtcacgaa taggatcgat gtcaaatact ttgtagtctt tgtgaacatc gtcgtaacca
     4861 ccattcaaac cagtaagaag ggctttaaga acgtttacac gagcaccgaa gtactggatg
     4921 ttgtggcgtt gttcttcatt ttctggatca agtggagaca cacagcatga gatacagctc
     4981 atttcaccat atccgtcttt agccattgtt gttacacctt cgtattggat agaagagtgt
     5041 ttgtggctca tgtgcataca gtagcgacgg aaattgtacg gcaatttgtc agtccaaaga
     5101 actgtcaagt ttggctctgg agagttaccg atgttgtcaa gagtgttcaa gaaacggtag
     5161 tccatcttag taacacggtg acgaccgtcg ttacccatac cagccataga agttgtgatg
     5221 aatgttgggt cacctgagta caattggtca taagcttttg tacgagcaaa tttaactgta
     5281 cgaagtttca taacgaaatc atcaacgaat tcttggattt ctgattcagt aaatgtacca
     5341 cgagcaaggt cacgttctgc aaagatgtcc aatacgattg gtacacgacc tagagatgta
     5401 gcagcaccgt taatcacacg gcagacagcc atgaaagcaa tgttaaccca ttggattgct
     5461 tctttcacgt tcatcgctgg tttgcgaaca tcaaccccgt aaaggtcacc caggcgaaca
     5521 acttgttgca atgcttggta ttgaaggttt acttcttcac gaagacggat tgtttcttca
     5581 tcgatttctt tgattgcatt ccagtcattt actttttctt gcatcaagta gtctgcaccg
     5641 taaagagcaa gacgtgcgta aacaccgatg atacgtccgc gtgagtatgc atctggaaga
     5701 ccagttacag tgtgtgcgtg acgagcgcga cgaatatttg aagtgtaggc acggaaaata
     5761 ccgtcgttaa ctgttgttac atatttagtg aagatttcgt gaacagctgg gtctggttcg
     5821 tatccatttt cttttaaagt agtttcagcc atacggatac caccttttgg catgaagttc
     5881 aatttgaaga gttcatcgtt ttggataccg aagataactt cattttcttt gtcgataaat
     5941 ccagcaggga tatcagcgat agatgttgga cgagtgtcca ttgggaaacg agtttcttcg
     6001 tagtgtgctt tagtttcttc tacaattttc ttgatgtgaa gtgaacgctc tgttggtcct
     6061 gcaaggaagc tttcgtctcc atcataaggt gtgtagttag cttgtacaaa gcgtgataca
     6121 cttgcttttt ctttccaatc tacgcctttg aagccttccc aagctttgtc aaaaatatct
     6181 tgtgcttcaa caactgtctt aacaaccata ttaatgtcct cttttttcta gtaacagtca
     6241 tctgttacat tcataagaca agtataccat aaagtaaccg atttcaacaa gtgcaaaatc
     6301 cctattttta cactttcttt tctaaaacag tctatatttt atttcaaact gtattatatt
     6361 tttgaaaaaa taaagtcctt ttttcttttt ttcagaaaaa agggtataat aaaagaaaat
     6421 aagcagtaac actcaatgga aatcgaaaag caaactagga agctagccgc aggctgctca
     6481 aagcactgct ttgaggttgt aaatagaact gacgaagtca gctcaaaata ctgttttgag
     6541 gttgcagatg gaagctgacg tggtttgaag agattttcga aaagtataaa aaggtgctag
     6601 gcatgttgat ttttcctttg ctaaatgatt tgtcaagaaa aatcatccat attgacatgg
     6661 atgccttttt tgctgcggtg gaaatcaagg ataatcctaa actcagagga aaacctgtca
     6721 ttattggaag cgaccctcgg caaacaggtg gacggggagt cgtttctacc tgtagctatg
     6781 aggctcgagc ttttggtgtc cattctgcca tgagttccaa ggaagcttat gaacgttgtc
     6841 cccaggccgt ctttatctca gggaattatg agaaatacaa agctgtggga ctccagattc
     6901 gagctatttt taagcgctat acagatttga ttgaacccat gagcattgac gaagcctatt
     6961 tggatgtgac agaaaataaa ctcggtatca agtcagcggt caaaattgct cgcctcattc
     7021 aaaaagatat ctggcaagaa ctccatctaa ctgcttccgc aggcgtttct tacaacaaat
     7081 tcttagctaa aatggcgagt gattatcaaa aaccacatgg tttgacagtg attctacctg
     7141 aacaggctga ggattttctc aaacaaatgg atatttccaa atttcatgga gtaggaaaaa
     7201 agacagtaga acgtcttcat caaatgggcg tttttactgg tgctgattta cttgaagttc
     7261 ctgaggtgac cctaatagac cgttttggta gactaggcta tgatctgtat cgaaaggctc
     7321 gtggcattca caactctcca gtcaaatcca atcgcatccg taaatcaatc ggcaaggaga
     7381 aaacctacgg gaagattctc cgtgctgagg aagatatcaa aaaagagctg actcttctat
     7441 cagaaaaagt cgctctcaat ctacatcaac aagaaaaagc tggaaaaatt gtcattttga
     7501 aaatccgcta cgaggacttt tcaactctta ccaaacgaaa aagtcttgct caaaaaacac
     7561 aagatgctag tcagataagc caaatagccc tgcaactcta tgaagaatta agcgagaaag
     7621 aaagaggtgt ccgcctattg gggattaccc tgactggatt ttaaagctca atgaaaatca
     7681 aagagcaaac taggaagcta gccgcaggct gctcaaaaca ctgttttgag gttgcagata
     7741 aagctgacgc ggtttgaaga gattttctaa gagtataaaa ccttgaagag ttgccccttc
     7801 aaggtttttc ttatacaaat aaacggacaa aactgtaaag tagcaaaaca ctaccaagca
     7861 cgatacggta tttaccaaaa agggtgaagt cgtgtttttt cacatagctg gtcaagaagc
     7921 gaatagccac catgctgacc gcaaaagcta ctcccatcgc gaccaagagc aaaaacaatt
     7981 gcccaaagct caagagttct cctgctttta caaatttgaa aatctttaag gcactagctc
     8041 caaacataac gggaatccca agatagaagg taaattctgt cacaactgaa cgactggttc
     8101 tatttaacaa accaccgaca atcgttgcac ctgaacggct agtccctggt aaaagagcaa
     8161 gaacttggaa gagtccaata tagaaagcgg tcgtataagg aagcttgtcc aactctgtta
     8221 cacttggctc gatagcacgc gctttattgc gcttttccaa atagatgaag gcaaccccgt
     8281 agataatcaa catgagagca actgaaacca tgttatggaa gtgggtatca aaccaatcat
     8341 caaatttaaa gacaccaagt aaaggtaaag tagcaatcaa gaccttcaac catagtctcc
     8401 aagtcttacg aacttcctgt ttgtccttag tcggtttaaa aggattgagc ttgttaaaat
     8461 aaatcaccat aactgctaaa atagcaccaa gctgaatcac gacattaaac atggacataa
     8521 aggcttcatt ttgattttgg tattggataa actcctctgc taaaatcaag tgacctgtac
     8581 tggaaatcgg caaccattcc gtaattcctt caacaatccc gaagaagata gattttaaaa
     8641 tttcaataag atacatagat ttctccttat attatattta acgcagttag ctactgccaa
     8701 agcccaagtg gtatacttgg aataagccac tgtggattag ttcatttcct ccaatcgctt
     8761 gacgatttcc gaaagggtct aaccacagct ttttgtttca attggtaatg agtttgataa
     8821 cgcatagacg ttttatctcg tctaaggtaa caaggcaaaa agttcgtgga taaccaagta
     8881 gacttgaaat actatatctg gaggtactcc catgctttat gtgggcattg atgtcgctaa
     8941 aaataaacac gatgttacag ccttgaatgt tcgaggaaaa ctgttcttaa accactcact
     9001 ttttcaaata ataaagctgg ttttgaactc ttagatctgt cttttcgaca gctcaaccaa
     9061 gactgtctca tcgctcttaa acttctttct gaccccaatc gtgaacaatt tcaacacgat
     9121 aatcggcaag tagaactaaa aatactggct agacatattc atcgtctcaa gaaaaaacag
     9181 tctgattgga aagtacaata cactcgttgt cttgatatca tctttcctga gttggataaa
     9241 atcgttggaa agcattcaga atatacctac caactcttga cacgctaccc taatcctcag
     9301 aaaaggcttg aggcaggatt tgataagctg atagaaatta agcgattgac cgcttctaaa
     9361 attcaggata tcctctcagt cgcacctcgt tctatcggaa caacatctcc tgctcgtgaa
     9421 ttcgaaatca tcgaaatcat caaacattac aagaggctca ttgacaaggc ggaaacatgt
     9481 gtcaatgact tgatggctga gttcaactcg gtcatcacga cggttactgg gattgggggt
     9541 cgtttagggg cggtcatttt agccgagatt cgaaatattc atgcctttga taatcctgct
     9601 caattacaag ctttcgctgg actggattct tctatttatc agtcaggtca gattgattta
     9661 gctggaagaa tggtcaaacg gggttcccct catctgcggt gggcactcat acaagctgcc
     9721 aaagcatgcg ctcgcttttc acctgctttt aaggcctatc ttaagactaa gttagaataa
     9781 ggaaaacatt acaatgtagc catcatccac cttgcaaaaa aacttatccg aaccctgttt
     9841 tatatcctaa aaaagagctg ccatttgacg aacaaaaagt gatgtaattt ctgaaattaa
     9901 cacaggatta c
//
LOCUS       DAVHSO010000080         9821 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.081, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000080 DAVHSO010000000
VERSION     DAVHSO010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9821)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9821)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9821
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.081"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            285..380
                     /locus_tag="VVR18_002009"
                     /pseudo
     CDS             285..380
                     /locus_tag="VVR18_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(633..1253)
                     /locus_tag="VVR18_002010"
     CDS             complement(633..1253)
                     /locus_tag="VVR18_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEU6033470.1"
                     /translation="MKLYFVRHGRTLWNQEGRFQGASGDSPLLPESIETLKRLGQYLK
                     EIPFDQIYSSDLPRAVKSAEIIQSQLHTPCSLEIVPNLREWQLGKLEGLKIATLEAIY
                     PQQIQAFRSNLAQFDTRMFGAESLYSTTQRTIQFIKSLKDSPAERILIVGHGANLTAS
                     LRTLLGYKEPLLRKDGGLANASLTIIETHDFETFTLNTWNDTSYQS"
     gene            complement(1253..1735)
                     /locus_tag="VVR18_002011"
     CDS             complement(1253..1735)
                     /locus_tag="VVR18_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA deacylase"
                     /protein_id="HEU6033471.1"
                     /translation="MAKKVKIKKTLVEQILSKAAIPHQGIQINALEGELPQGYERDQI
                     FKTLALLGDKTGPIIGIVPITQHLSEKKLAKISGNKKVSMIPQKDLEKTTGYIHGANN
                     PVGIRQKHNYPIFIDKIALDLDRMIVSAGEVGHSIIVAPQDLASFVKADFVDILEDIK
                     "
     gene            complement(1735..2577)
                     /locus_tag="VVR18_002012"
     CDS             complement(1735..2577)
                     /locus_tag="VVR18_002012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF368 domain-containing protein"
                     /protein_id="HEU6033472.1"
                     /translation="MLSWLARVIKGIVIALGFILPGISGGVLAAILGIYERMIGFLAH
                     PFKDFKENVLYFIPVAIGMLLGIGLFSYPIEYLLENYQVFVLWSFAGAIIGTVPSLLK
                     ESTRESDRDKIDLAWLWTTFIISGLGLYALNFVVGTLSASFLNFVLAGALLALGVLVP
                     GLSPSNLLLILGLYAPMLTGFKTFDFLGTFFPIGIGAGATLIVFSKLMDYALNNYHSR
                     VYHFIIGIVLSSTLLILIPNAGNAESIQYTGLSLVDYVIIAFFFALGIWLGIWMSQLE
                     DKYK"
     gene            complement(2672..3472)
                     /locus_tag="VVR18_002013"
     CDS             complement(2672..3472)
                     /locus_tag="VVR18_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 25 protein"
                     /protein_id="HEU6033473.1"
                     /translation="MRKQIHPLILFSFFGIMMFILIINRPLNDSQSFKTKSNIAQIEA
                     QALKHLDKPIIDLSGWQRPEEINYDALSQNISGAIVRVHSGAQTTKENDASFINGIDK
                     AYKSHITELQKRNVPVAVYAYVAGKSVQEMEKAAEVFYNAASPYSPSYYWLDVEDKTM
                     SNMNEGVENFRAKLASLGAKNIGIYVGVYFMEEHSIDTGKFTSVWIPSYGSDSGFLES
                     SPKTDLDYDIHQYTSKGKIAGFDHDLDINVISPLKNKEETFRKLFLKP"
     gene            3616..4995
                     /gene="glmU"
                     /locus_tag="VVR18_002014"
     CDS             3616..4995
                     /gene="glmU"
                     /locus_tag="VVR18_002014"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HEU6033474.1"
                     /translation="MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQ
                     PEKTVTVVGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGD
                     TPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATD
                     FEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLK
                     DFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVNPEATYIDIDVEIAPEVQIEA
                     NVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVTVGPYAHIRPN
                     SSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKY
                     KTVIGDNVFVGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRSRQINKDEYAT
                     RLPHHPKNQ"
     gene            5005..5550
                     /locus_tag="VVR18_002015"
     CDS             5005..5550
                     /locus_tag="VVR18_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU6033475.1"
                     /translation="MEFEEKTLSRKEIYQGPIFKLVQDQVELPEGKGTAQRDLIFHNG
                     AVCVLAVTDEQKLILVKQYRKAIEAVSYEIPAGKLEVGENTAPVAAALRELEEETAYT
                     GKLELLYDFYSAIGFCNEKLKLYLASDLTKVENPRPQDEDETLEVLEVSLEEAKELIQ
                     SGHICDAKTIMAVQYWELQKK"
     gene            5562..5876
                     /locus_tag="VVR18_002016"
     CDS             5562..5876
                     /locus_tag="VVR18_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="foldase"
                     /protein_id="HEU6033476.1"
                     /translation="MGKSLLTDEMIERANRGEKISGPPLLDDNEETKILPTSSSRFGY
                     ANPKDHGFSQETLKIQVEPSIHKSRRIENTKRNVFNSKLNKILFAVIFLLILLVLAMK
                     LL"
     gene            5893..6585
                     /locus_tag="VVR18_002017"
     CDS             5893..6585
                     /locus_tag="VVR18_002017"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HEU6033477.1"
                     /translation="MKIGIIAAMPEELAYLVQHLDNAQEQVVLGNTYHTGTIASHEVV
                     LVESGIGKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDV
                     TAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEA
                     IKSHFPEVLAVEMEGAAIAQAAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRS
                     AQVLLTFLKALD"
     gene            6662..7153
                     /gene="rocS"
                     /locus_tag="VVR18_002018"
     CDS             6662..7153
                     /gene="rocS"
                     /locus_tag="VVR18_002018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein RocS"
                     /protein_id="HEU6033478.1"
                     /translation="MSIEMTVSEIAEVLGLSRQAINNRVKELPEEDTDKNDKGVTVVT
                     RSGLIKLEEIYKKTIFEDEPVSEDVKQRELMEILVDEKNAEILRLYEQLKAKDRQLSE
                     KDEQMRIKDRQIAEKDKQLDQQQQLTLQAMKDQENLKLELDQAKEEVQSTKKGFFARL
                     FGG"
     gene            7251..7841
                     /locus_tag="VVR18_002019"
     CDS             7251..7841
                     /locus_tag="VVR18_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HEU6033479.1"
                     /translation="MERLEDYIAFDLEFNQHEGQTHLIQVSAVRFRDGREIDAYDSYV
                     HTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAE
                     HGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
                     VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD"
     gene            7850..9613
                     /locus_tag="VVR18_002020"
     CDS             7850..9613
                     /locus_tag="VVR18_002020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HEU6033480.1"
                     /translation="MKPEKPKKLGLKQIYLNLDKILFLFFLIFMIVEYLWVPFNSWLA
                     SFLLDQTGYLFISYNNVLAILTHSPLISLAFLALIVINLLVAYFQIGLLFIGARHLLY
                     NEKRRLIEYIRKVFHESFGFMKKLTCAKALFIFFYIAMLFPFIRKMLKIYYLNKIVIP
                     EFIQAYLEDKYWMWWLSILLLSLIFLYVSVRLMFALPKIVYDQLTVREAVMFSLEKTK
                     KRVTFYAWNLFYILLKAHLLFYLPLIPLLLAQTLVDDITQRESLILGILNFVVIKNLY
                     YMALTYFLVKFVSFLTGKELDMLPRREKDHIVRWGVMTCASLFFALEGYIYLEAPMVH
                     LPQLISHRGVSNANGIQNTVESLETTAQLKPDLVETDVQETKDGQFVMMHDANLKNLA
                     GINKSPQDLNLEELKGIDIFENGYQTKISSFEDYLSRANELGQKLLIEIKTSKKDSPD
                     MMNRFLARYAAKLKIYGHQIQSLDYHVVEKVRQYDAELPVYFIMPYNSVFPKTRATGY
                     TMEYSTLDEYFVSKLWTTDQKLYVWTVNDSEAISKSLHLGVDGVITDDLEKVQREIEV
                     AQEDPEYTDLLLKKALEFFEF"
BASE COUNT         3044 a         1699 c         2087 g         2991 t
ORIGIN      
        1 tttcataata aaaacacccc aaaagttaga ttttttctgt ctaacttttg gggtgtagtt
       61 catgtacacc tgatatgatg cgttttataa ttttaaagac tttttgacca gcctcatttt
      121 tttaacttga tactcagtga aaagcaaaga ttaaactagg aagctagctg taggctgctc
      181 aaagaacagc tttgaggttg cagataaaac ttgtgaggta accaacatat ataatgtgaa
      241 gctgacgtgg tttgaataga ttttagaagg gtatgagtct ggaagtttta atggataatg
      301 caagattcca tagaatgggt aagctagagt tcttatgtga agagtttggg cataaacttt
      361 taccttttcc tccctactca tcttagtata gaaaagtgaa tctaaaatag tacataactg
      421 cttctaaaac attcttataa attgatttaa attctcaaat catattattc agttcttatt
      481 tcattttgct ctacaatcct gttgagaaga cacgtgttca tatcaaaaag gtattggcaa
      541 gttgcaatac ctttttacaa ggttcttttg tcttattttt gtttcaactg actatatctc
      601 ctatggttct agttcagaag gctaggctat aattatgatt gataagaagt atcattccaa
      661 gtattgagag tgaatgtttc aaaatcatgg gtttctataa tggtcaggct ggcatttgct
      721 agaccgccat ctttacgaag aagtggttct ttatagccta ggagagtacg aagactggca
      781 gtaagattgg cgccgtgtcc gacaattaga atacgctcag ctggactatc ttttaatgat
      841 ttgataaatt ggatggtccg ctgagttgta ctatagaggg attcggctcc gaacattcga
      901 gtgtcaaatt gagcaagatt tgaacgaaaa gcctggattt gttgcgggta aatagcttcc
      961 agggttgcaa ttttcaaacc ttctaacttc ccaagttgcc attcacggag attaggaacg
     1021 atttctaaag aacagggggt atggagttga ctttggataa tctcagcaga tttgaccgct
     1081 cgaggtaaat cacttgaata aatctgatca aaaggaattt ccttgagata ctggccaagt
     1141 cgttttaggg tttcaatgga ttcaggaaga agaggagaat caccgctagc accttgaaaa
     1201 cgaccttctt ggttccagag ggtacgaccg tggcggacaa agtagagttt cattacttga
     1261 tgtcctccaa aatatctaca aagtctgcct ttacaaagct agccaagtct tgtggcgcga
     1321 cgataatgct gtgtccgact tcgcctgcag agacaatcat tcgatccaaa tctagagcaa
     1381 ttttatcgat aaaaatggga taattgtgtt tctgacgaat tccgacagga ttattggctc
     1441 catgaatgta accagttgtt ttttctaagt ccttttgtgg aatcatgctc acttttttat
     1501 tgccagaaat tttagctagt ttcttttcag acaagtgctg agtgataggg acaattccga
     1561 taatcggtcc ggtcttgtct cccaaaagcg ccaaggtttt gaaaatctga tctcgttcat
     1621 aaccttgagg aagctctcct tctagggcat tgatttgaat cccctgatga gggatagctg
     1681 ctttagatag gatttgttcc accaatgttt ttttgatttt aacttttttt gccattattt
     1741 atatttatcc tccaattgac tcatccaaat accaagccag attcccagcg caaagaagaa
     1801 ggcgatgatg acataatcga caagtgaaag tcctgtgtat tggatacttt cagcgtttcc
     1861 tgcatttgga attaagatca aaagggtact tgataggacg ataccgatga tgaaatgata
     1921 gacgcgtgag tggtagttgt ttaaggcata atccatcaat tttgaaaaaa cgatgagagt
     1981 tgcacctgca ccaattccaa tcggaaagaa ggttcccaag aaatcaaaag ttttaaaacc
     2041 agtcaacata ggagcataga gtcccaaaat caaaagtaaa tttgatgggc tgaggccagg
     2101 aaccaagacg ccaagggcca atagtgcgcc tgctaggacg aagttaagaa agctggcgct
     2161 taaggttcca acgacaaaat ttaaggcata gagtcctaat ccagaaatga taaaggttgt
     2221 ccataaccaa gctaaatcaa tcttgtctcg gtcagattct cgagttgatt ctttgaggag
     2281 gctaggaact gtaccgataa tagctcccgc aaagctccat aatacaaaaa cctgataatt
     2341 ttcaagcagg tattcaatcg ggtaggaaaa taagccgatt cccagaagca taccgatggc
     2401 aactggaata aagtacaaaa cattttcttt aaagtcttta aagggatggg ccagaaagcc
     2461 aatcattcgt tcatagattc ctaagattgc tgctagaacc cctccggaaa ttcccggtag
     2521 gataaatcca agagcaatta caatcccttt aataacgcgt gctaaccatg agagcatata
     2581 tttcctccaa ctatttctat ttcaaaaaat ccttactata ttgtatcaca atcagacaca
     2641 aaaagaaaaa gcaaatgata aacaaatgct tttaaggttt taaaaaaagt tttcgaaagg
     2701 tttcttcttt attttttaag ggagagataa cgttgatatc taaatcgtgg tcaaagccgg
     2761 caatttttcc tttagatgtg tattggtgaa tatcataatc taaatcagtt ttaggactgc
     2821 tctccaaaaa tcctgagtct gagccgtagg acggaatcca aacagaggta aacttgcctg
     2881 tatcaatact gtgttcttcc atgaagtaga caccaacgta gatgccgatg tttttagcac
     2941 ctagtgatgc tagttttgct cgaaagtttt cgacaccttc gttcatatta gacatggttt
     3001 tgtcttccac gtcaagccaa tagtaactag ggctgtaagg agaggcagca ttgtagaaaa
     3061 cttcggcagc cttttccatt tcttggacac tttttccagc tacataagcg tagacagcaa
     3121 ctgggacatt ccgcttttga agttcagtga tatgactctt ataggccttg tctattccat
     3181 tgataaatga agcatcattt tcttttgttg tttgagcacc actgtgaaca cgaacaatag
     3241 cacctgaaat attttgtgag agggcatcgt agttgatttc ctcaggacgc tgccagccag
     3301 agaggtcaat aatcggtttg tctaagtgtt tcaaagcctg tgcttcaatc tgtgctatat
     3361 tggattttgt tttaaacgat tggctgtcat taagtgggcg attgatgatt aaaatgaaca
     3421 tcataatccc aaaaaaacta aataaaataa gtggatgaat ttgttttctc atatcttata
     3481 agtctaccct aaaaatcaaa aaaaatcaaa aaaatgggtt aaggaagaga ctttagagca
     3541 ttttttcatt caagagtgcg gaatgatttg aaatatggta taataaaagg gaatttctac
     3601 agaaaagaga agattatgtc aaattttgcc attattttag cagcgggtaa agggactcgc
     3661 atgaaatctg atttgccaaa agttttgcac aaggttgcgg gtatttctat gttggaacat
     3721 gttttccgta gtgtgggagc tatccaacct gaaaagacag taacagttgt aggacacaag
     3781 gcagaattgg ttgaggaggt cttggctgga cagacagaat ttgtgactca atctgaacag
     3841 ttgggaactg gtcatgcagt tatgatgaca gaacctatct tagaaggttt gtcaggacac
     3901 accttggtca ttgcaggaga tactccttta atcactggtg aaagcttgaa aaacttgatt
     3961 gatttccata tcaatcataa aaatgtggcc actatcttga ctgctgaaac ggataatcct
     4021 tttggctatg gacgaattgt tcgtaatgac aatgctgagg ttcttcgtat tgttgagcag
     4081 aaggatgcta cagattttga aaagcaaatc aaggaaatca acactggaac atacgtcttt
     4141 gacaacgagc gtttgtttga ggctttgaaa aatatcaata ccaataacgc tcaaggcgaa
     4201 tactatatta cagacgtcat tggtattttc cgtgaaactg gtgaaaaagt tggcgcttat
     4261 actttgaaag attttgatga aagtcttggg gtaaatgacc gtgtggcgct tgcgacagct
     4321 gagtcagtta tgcgtcgtcg catcaatcat aaacacatgg tcaacggtgt tagctttgtc
     4381 aatccagaag caacttatat cgatattgat gttgagattg ctccggaagt tcaaatcgaa
     4441 gccaatgtta ccttgaaagg gcaaacgaaa attggtgctg agactgtttt gacaaatggt
     4501 acttatgtag tggacagcac tatcggagca ggagcggtca ttaccaattc tatgattgag
     4561 gaaagtagtg ttgcagacgg tgtgacagtc ggtccttatg ctcacattcg tccaaattca
     4621 agtctgggtg cccaagttca tattggtaac tttgttgagg tgaaaggatc ttcaatcggt
     4681 gagaatacca aggctggtca tttgacttat atcggaaact gtgaagtggg aagcaacgtt
     4741 aatttcggtg ctggaactat tacagtcaac tatgacggca aaaacaaata caagacagtc
     4801 attggagata atgtctttgt tggttcaaat tcaaccatta ttgcaccagt agaacttggt
     4861 gacaattccc tcgttggtgc tggttcaact attactaaag acgtgccagc agatgctatt
     4921 gctattggtc gcagtcgtca gatcaataaa gacgaatatg caacacgtct tcctcatcat
     4981 cctaagaacc agtaggagcc tatcatggag tttgaagaaa aaacgcttag ccgaaaagaa
     5041 atctatcaag gaccaatatt taaactggtc caagatcagg ttgaattacc agaaggcaag
     5101 ggaactgccc aacgggattt gattttccac aatggggctg tctgtgtttt agcagtaacg
     5161 gatgaacaaa aacttatctt ggtcaagcag taccgcaaag ctatagaggc tgtctcttac
     5221 gaaattccag ccggaaaatt ggaagtagga gaaaacacag cccctgtggc agctgccctt
     5281 cgtgaattag aggaagaaac agcctataca gggaaattag aactcttgta cgatttttat
     5341 tcagctattg gcttttgtaa tgagaagtta aaactatatt tagcaagcga tttgacaaaa
     5401 gtggaaaatc cgcgtccgca ggatgaggat gaaaccttgg aagtccttga agtgagctta
     5461 gaagaagcga aagaattaat ccaatcaggt catatttgtg atgccaaaac aattatggct
     5521 gttcagtatt gggagttgca gaaaaaatag aggaggtcag tatgggtaaa tctttattaa
     5581 cggatgaaat gattgaaaga gctaatagag gcgaaaaaat ttcaggtcct cctttgctag
     5641 atgataatga ggaaactaag attttaccaa cctcttcttc ccgttttggt tatgccaatc
     5701 ctaaggatca tggttttagc caggaaacct tgaagattca ggtcgaacca tctattcata
     5761 aaagccgtcg tattgaaaat accaagagaa atgtcttcaa ttctaagttg aataaaatct
     5821 tattcgcggt catctttctc ttgattttgc ttgttttagc aatgaaactt ttgtaataga
     5881 aaaggaattg aaatgaaaat aggaattatt gctgctatgc cagaagaact ggcttatctg
     5941 gtccagcatt tagacaatgc ccaggagcaa gttgttttgg ggaataccta tcatacagga
     6001 accattgctt ctcatgaagt cgttcttgta gaaagtggaa ttggtaaggt catgtctgct
     6061 atgagtgtgg cgattttggc tgatcatttc caggtggatg cccttattaa tacgggttca
     6121 gctggggcag tagcagaagg tatcgctgtt ggggatgtcg tgattgctga caaattagcc
     6181 tatcatgacg tggatgtcac agcttttggc tatgcttatg gacaaatggc gcaacaaccg
     6241 ctttatttcg aatcagacaa aacctttgtt gctcaaatcc aagagagttt atctcaattg
     6301 gaccaaaact ggcatcttgg tttgattgct acaggagata gttttgttgc aggaaatgac
     6361 aagatagaag cgattaagtc ccatttccca gaagttttag ccgtggagat ggagggggca
     6421 gctattgctc aagcagcgca tgccctcaat ctcccagtct tagtcatcag agctatgagt
     6481 gacaatgcca accatgaagc aaacatcttt tttgatgagt ttattatcga agctggacgt
     6541 cgctctgccc aagtcttgtt gacctttttg aaggctttag attaagcgga aatttgacag
     6601 tttttctagc ttatgataag atttaagtaa agaaaagcta gaaaacgttt cagaggatat
     6661 tatgagtatt gaaatgaccg tcagtgagat tgcagaggtc ttaggattat ctcgccaagc
     6721 aatcaataac cgtgtcaaag aattaccaga agaagacaca gataaaaatg acaaaggggt
     6781 aacagttgtt accagaagtg gcttgattaa gctagaagaa atctataaaa aaacgatttt
     6841 tgaagatgag cctgtcagtg aagatgtcaa acaacgtgaa ctgatggaga ttctagtgga
     6901 tgagaagaat gcagaaattc ttcgtcttta tgaacaatta aaagccaagg atcgtcagtt
     6961 atcagaaaaa gacgagcaga tgcgtatcaa agaccgtcag attgctgaga aagacaaaca
     7021 attagatcag caacaacaat tgacccttca agccatgaag gatcaagaaa atcttaagct
     7081 agagctggac caagcaaaag aagaagtcca atccactaag aaaggctttt ttgctcgttt
     7141 atttggagga taatcaagga gctgtttagg ttaaatgcta acctgatggc ttcttttgtt
     7201 tgtgaatagt atagttgatt agaacagaga cagtagagga gaggtacaga atggaacgat
     7261 tagaagatta cattgctttt gacttagaat ttaatcagca cgaaggacaa acacacttga
     7321 ttcaagtatc ggcagtgcgt tttagagatg gtcgggaaat cgatgcctat gattcctatg
     7381 ttcataccag cgtccctcta aaaagcttta tcaatggttt gaccgggatt acagctgaga
     7441 ccttaaaaga tgctcctcca gttgagaaag tcttagaaga attccaagag tttgtgggtt
     7501 ctttgctgat gataggctac aatgctgcta aaagtgattt acctatttta gcagagcatg
     7561 gtttagacta tagccaacag tacaaggtgg atttgtatga tgaagctttt gaacgtcgga
     7621 gttcagattt acatggtatt gccaatctca aattgcaaac tgttgcctca tttcttggat
     7681 ttcaaggtca gtctcataat agtttagagg atgctcggat gacggcgcgt gtttacgaat
     7741 ccttcttaga gtcggatcaa gctagggaat tgttagagac agaaagtagc ttatcaaaca
     7801 atccttttgg tggcttggac ttgtctcaat tatttgacta ggagtgccta tgaaacctga
     7861 aaaacctaaa aaattgggtc ttaaacagat ttacctcaat cttgataaaa tcctctttct
     7921 atttttcttg atttttatga tagtggagta tttgtgggta ccattcaatt catggttggc
     7981 tagcttctta ttagatcaga caggttatct ttttatttcc tataacaatg tcttagccat
     8041 ccttactcat tctccattga ttagtctagc ttttttagcc ttgattgtaa ttaaccttct
     8101 ggttgcttat tttcaaatag gactcctctt tattggtgct cgtcatctcc tctataatga
     8161 aaagcgaagg ctaattgagt atatccgcaa ggttttccat gaaagttttg gatttatgaa
     8221 aaagctaact tgcgctaaag ccttgtttat ctttttctat atagctatgc tttttccttt
     8281 tatacggaaa atgctgaaga tttattatct taataaaatc gtcatcccag agtttatcca
     8341 agcttattta gaagataaat attggatgtg gtggctgagc atcctacttc tatctcttat
     8401 ctttctctat gtctctgtca gattgatgtt tgcccttccg aagattgtat atgatcagct
     8461 gactgttcga gaagcagtga tgtttagctt ggagaaaacc aagaagagag ttacttttta
     8521 tgcttggaat ttattttaca tcttgctcaa agcacattta ttattttatc ttcctttgat
     8581 tcctttatta ttggctcaaa ctttggtaga tgatatcact cagagagagt ctctgattct
     8641 tggtattttg aattttgtcg tgattaaaaa tctctattat atggctctga cttatttttt
     8701 ggttaaattt gtttcatttt tgacaggaaa ggagttggat atgcttccta ggagagaaaa
     8761 agatcacatc gtgcgatggg gtgtcatgac ttgtgccagt cttttctttg ccttagaagg
     8821 ttatatttat ctggaggctc ccatggttca tctacctcaa cttatttctc accgaggggt
     8881 ttccaatgca aatgggattc aaaatacagt agagtccttg gaaactacag cacaactcaa
     8941 accagacttg gtggagacgg acgtgcagga aacaaaagat gggcagtttg tcatgatgca
     9001 tgatgctaac ttgaaaaatt tagcaggtat caataaaagt cctcaagact taaacttgga
     9061 ggagcttaaa gggattgata tttttgaaaa tggctaccag actaaaattt caagctttga
     9121 agattatctc agtcgagcca acgaacttgg tcaaaaatta ctaattgaaa ttaaaaccag
     9181 taaaaaagat agtccagaca tgatgaaccg ctttttagcc cgttatgctg caaagctcaa
     9241 gatttatgga catcaaatcc agtctttaga ctaccatgtt gtcgaaaaag taagacagta
     9301 tgatgccgaa ctgccagttt atttcatcat gccctacaat tctgtctttc ctaaaacaag
     9361 agcgacagga tatactatgg agtactcaac cttggatgaa tattttgtaa gcaaactatg
     9421 gacaacggat cagaaacttt atgtctggac tgtcaatgat tcagaagcta tcagcaaatc
     9481 tcttcactta ggagtagatg gagtgattac agatgatttg gaaaaagttc agcgggaaat
     9541 agaagtagcc caagaagatc cagaatatac ggatttgctc ttgaaaaaag cattggaatt
     9601 ctttgaattt tagtaataaa aaagaggaac ggttgttcct cccatgatag gtaagtattc
     9661 ttgtgaatgc ttgctttttt gtggttgcaa tccgtttacg agaattgttt gtattgttct
     9721 tgtttcaatt tactttatag tgctttgaag ttggaatgct acactataac ttctaaaata
     9781 tagtaaaatg aaccaaaaat agtacacaat gtggtataat c
//
LOCUS       DAVHSO010000081         8224 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.082, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000081 DAVHSO010000000
VERSION     DAVHSO010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8224
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.082"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            48..263
                     /locus_tag="VVR18_002021"
     CDS             48..263
                     /locus_tag="VVR18_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdbC family protein"
                     /protein_id="HEU6033481.1"
                     /translation="MAEFTFEIEEHLLTLSENEKGWTKEINRVSFNGAPAKFDIRAWS
                     PDHTKMGKGITLSNEEFQTMVDAFKGN"
     gene            complement(332..412)
                     /locus_tag="VVR18_002022"
                     /pseudo
     CDS             complement(332..412)
                     /locus_tag="VVR18_002022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(468..1004)
                     /locus_tag="VVR18_002023"
     CDS             complement(468..1004)
                     /locus_tag="VVR18_002023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000709035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HEU6033482.1"
                     /translation="MKKAHVYAIPAIGAALIAVLAQISLPIGPVPFTLQNFAIGLIAT
                     VFRPREAVLSAGLYLLLGAIGLPVFAGGGAGFQALVGPTAGYLWFYLVYSGLTSSLTN
                     SKSGVVKIFLANLLGDALVFVGGILSLHFLAGMAFEKALVVGVLPFIIPDLGKLLAIS
                     FISRPLLQRLKNQAYFTN"
     gene            complement(1201..2547)
                     /gene="gor"
                     /locus_tag="VVR18_002024"
     CDS             complement(1201..2547)
                     /gene="gor"
                     /locus_tag="VVR18_002024"
                     /EC_number="1.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-disulfide reductase"
                     /protein_id="HEU6033483.1"
                     /translation="MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNV
                     GCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDFATLRRNRESYIDRARSSYDGSF
                     KRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
                     AWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEME
                     RTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVT
                     LNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDY
                     STIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLI
                     TAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGVTKADFDATVAIHPTSSEEFVTMR"
     gene            2812..4011
                     /locus_tag="VVR18_002025"
     CDS             2812..4011
                     /locus_tag="VVR18_002025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HEU6033484.1"
                     /translation="MKKKNGKAKKWQLYAAIGAASVVVLGAGGILLFRQPSQTALKDE
                     LTHLVVAKEGSVASSVLLSGTVTAKNEQYVYFDASKGDLDEILVSVGDKVSEGQALVK
                     YSSSEAQAAYDSASRAVARADRHINELNQARNEAASAPAPQLPAPVGGEDATVQSPTP
                     VAGNSVASIDAQLGDARDARADAAAQLSKAQSQLDATTVLSTLEGTVVEVNSNVSKSP
                     TGASQVMVHIVSNENLQVKGELSEYNLANLSVGQEVSFTSKVYPDKKWTGKLSYISDY
                     PKNNGEAASPAAGNNTGSKYPYTIDVTGEVGDLKQGFSVNIEVKSKTKAILVPVSSLV
                     MDDSKNYVWIVDEQQKAKKVEVSLGNADAENQEITSGLTNGAKVISNPTSSLEEGKEV
                     KADEATN"
     gene            3995..4696
                     /locus_tag="VVR18_002026"
     CDS             3995..4696
                     /locus_tag="VVR18_002026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033485.1"
                     /translation="MKQLISLKNIFRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSG
                     SGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEKQLAKVRNQQIGFVFQQFFLLSKLN
                     ALQNVELPLIYAGVSSSKRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARALV
                     NNPSIILADEPTGALDTKTGNQIMQLLVDLNKEGKTIIMVTHEPEIAAYAKRQIVIRD
                     GVISSDSAQLGKEEN"
     gene            4698..5957
                     /locus_tag="VVR18_002027"
     CDS             4698..5957
                     /locus_tag="VVR18_002027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033486.1"
                     /translation="MQNLKFAFSSIMAHKMRSLLTMIGIIIGVSSVVVIMALGDSLSR
                     QVNKDMTKSQKNISVFFSPKKSKDGSFTQKQSAFTVSGKEEEVPVEPPKPQESWVQEA
                     AKLKGVDSYYVTNSTNAILTYQDKKVENANLTGGNRTYMDAVKNEIIAGRSLREQDFK
                     EFASVILLDEELSISLFESPQEAINKVVEVNGFSYRVIGVYTSPEAKRSKIYGFGGLP
                     ITTNISLAANFNIDEIASIVFRVNDTSLTPTLGPELARKMTELAGLQQGEYQVADESV
                     VFAEIQQSFSFMTTIISSIAGISLFVGGTGVMNIMLVSVTERTREIGLRKALGATRAN
                     ILIQFLIESMILTLLGGLIGLTIASGLTALAGLLLQGLIEGIEVGVSIPVALFSLAVS
                     ASVGMIFGVLPANKASKLDPIEALRYE"
     gene            6081..8078
                     /gene="metG"
                     /locus_tag="VVR18_002028"
     CDS             6081..8078
                     /gene="metG"
                     /locus_tag="VVR18_002028"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HEU6033487.1"
                     /translation="MSEKNFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGYDV
                     FYLTGLDEHGQKIQQKAEEAGITPQAYVDGMAVGVKELWQLLDISYDKFIRTTDDYHE
                     KVVAQVFERLLAQDDIYLGEYSGWYSVSDEEFFTESQLAEVFRDEAGNVTGGIAPSGH
                     EVEWVSEESYFLRLSKYQDRLVEFFKAHPEFITPDGRLNEMLRNFIEPGLEDLAVSRT
                     TFTWGVPVPSNPKHVVYVWIDALLNYATALGYAQDEHGNFDKFWNGTVFHMVGKDILR
                     FHSIYWPILLMMLDVKLPDRLIAHGWFVMKDGKMSKSKGNVVYPEMLVERYGLDPLRY
                     YLMRNLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVSMINKYFDGQIPAYVEGVT
                     EFDHVLAEVAEQSIADFHTHMEAVDYPRALEAVWTLISRTNKYIDETAPWVLAKDEAL
                     RDQLASVMSHLAASIRVVAHLIEPFMMETSRAVLTQLGLEEVSSLENLSLADFPADVT
                     VVAKGTPIFPRLNMEEEIAYIKEQMEGNKPAVEKEWNPDAVELKLNKDEIKFEDFDKV
                     EIRVAEVKEVSKVEGSDKLLQFRLDAGDGEDRQILSGIAKYYPNEQELVGKKVQIVAN
                     LKPRKMMKKYVSQGMILSAEHDGKLTLLTVDPAVPNGSVIG"
BASE COUNT         2513 a         1557 c         1817 g         2337 t
ORIGIN      
        1 tacaagattt tacgaataaa ctaatgaaac taaaaaagga gaagaaaatg gcagaattta
       61 catttgaaat cgaagagcac ttgttgactc tttctgaaaa cgaaaaaggt tggaccaagg
      121 aaattaaccg tgtgagcttt aatggtgccc ctgcaaagtt tgatattcgt gcttggagtc
      181 cagaccatac taaaatgggc aaagggatta ctctctcaaa tgaagaattt caaacgatgg
      241 tggatgcctt taaaggcaac taatactctt cgaaaatctc ttcaaaccgc atcagctttg
      301 ccttgccgta tgtatggtta ctgacttcgt cagtttcatc cacaacctca aaacagtgtt
      361 ttgagcagcc tgcggctagc ttcctagttt gctctttgat tttcattgag tataagtttt
      421 caaaataaaa aaaaggatat tgagtcatga taactcggta tcctttttta gttagtaaag
      481 taagcctgat ttttaaggcg ttgaagtagg ggacggctaa taaaactaat agccagaagt
      541 ttgccaaggt ctggaatgat aaagggaaga acccccacaa caagagcttt ttcaaatgcc
      601 attccagcta ggaaatgcaa gctgagaatc ccgccgacaa agacaagggc atcacccaag
      661 aggtttgcaa gaaaaatctt aacaacacca ctcttgctgt tagttagaga ggaagtaagt
      721 ccagagtaaa cgagataaaa ccaaagatag cctgcagtag ggccaactaa agcctgaaaa
      781 ccagctccac ctcctgcaaa gacaggaaga ccgatagcac ctagaagaag atagagtcca
      841 gcagaaagta cagcctctct cggtctaaag acagtagcaa tcaagccgat tgcaaagttt
      901 tgcagagtga agggaacagg tccaattgga agactgattt gtgccaaaac agcaatgaga
      961 gcagccccaa tagcagggat agcataaacg tgagcttttt tcaaaatagt taacctcttt
     1021 tctaatgtat agtaactatt atactcatat aggagtcgat gtcaaccatt ttttaaaaac
     1081 aaggtaacaa aaactgtaac agccgatttt cgtgactagt caagttggat aatttttttg
     1141 ttgattcgaa aatcattaaa aaagaagcag acatatttat atcagcttct tttgtttcga
     1201 ttaacgcatg gttacaaatt cttcagatga agttgggtga atcgctacag ttgcgtcaaa
     1261 gtcagccttg gttactccca ttttgatagc aacggcaaat ccctgaatca tttcatcaac
     1321 gccgtagcca attccatgaa gtccgacaac tttttcttct gaaccagctg ttatgagttt
     1381 gaaacgggat tcttgacggt tgcgagtgca agcagagtac atagatgcaa agcttgattt
     1441 gtaaaccttg atttggtctt gaccgtattc tttaatagct tgctcttctg tcaaaccaac
     1501 agttccgata gcagggtgtg aaaagacaac agttggaata gttgagtaat ccatttttgc
     1561 agtagttttt ccgttaaaga gacgttcaga tagggtacgt ccggccttga ttgcaactgg
     1621 agtcagttct ttctcgcccg ttacatcacc tagagcatag attccctcaa caacagtatt
     1681 ttggtattca tccacttgga taaagccacg ttcgttcaga gtcactccag ctttttcaag
     1741 ttgcaagccc ttaacgtttg gacggcggcc tgtagcccag ataacttggc tagctgtgtg
     1801 actagtacca tcttcgaaat gaatggtaat gccgtcagta gttttttcta acttgacagg
     1861 gactttgtga gtgtgaagtg gtaagtttgt tctttccatt tccttgacca aaccttcaac
     1921 gatgtaggaa tcaaaaccac gtaaaggacg atcgcggcga acaaagagat ctgtcttgac
     1981 accaaaagtg tggagtacgc cagctaattc aacggcgata taaccagcgc ctagaatggc
     2041 aactgactct ggaagttctt cccaggcaaa tacatcatca gaagagccac ctagctcagc
     2101 accaggaata ttaggaatac ttggatgggc acctgtagca atcacgatat gtttagcacg
     2161 aatcagttca ccatttacgc ttacagtatg agaatctaca aattcagcat gaccttcaat
     2221 caagtctaca ccgttgcgtt taaaactgcc atcataagaa gaacgagcgc gatcaatgta
     2281 ggattcacga ttgcgacgta gggttgcaaa gtcaaagtta agatcagtag tcttaaagcc
     2341 gtagtcttct ccaaattgat ggaaagtctc agcgatttgt gccccgtacc acatgatttt
     2401 tttaggaaca caaccgacgt tgacacaggt tccacctaat ttcttttcct caataacggc
     2461 tgcttgggct ccatgttcac cagcacggtt catggtagcg attcctccgc tacctccacc
     2521 gatagcaatg atatcatatt ctctcattga aaactccttt gtaatctttt aaatagtaga
     2581 gcgtcttttt tgatagttat attttattct ttttttgatt tgattgcaaa aatctgctac
     2641 gcacaaaaaa ttgcaaaaaa gcttgccaaa taagtcaaga tagtgtatta tatatctagt
     2701 acaatagaaa agcaaaattc cgaacgattg tttaatcctg aactgtattg tttgctggag
     2761 ggaaatttgg tataatagca aagtattgta aaaaagaaaa ggagtttcat tatgaagaaa
     2821 aagaatggta aagctaaaaa gtggcaactg tatgcagcaa tcggtgctgc gagtgtagtt
     2881 gtattgggtg ctggggggat tttactcttt agacaacctt ctcagactgc tctaaaagat
     2941 gagcttactc atcttgttgt tgccaaggaa ggaagcgtgg cctcctctgt tttattgtca
     3001 gggacagtaa cagcaaaaaa tgaacaatat gtttattttg atgctagtaa gggtgattta
     3061 gatgaaatcc ttgtttctgt gggcgataag gtcagcgaag ggcaggcttt agtcaagtac
     3121 agtagttcag aagcgcaggc ggcctatgat tcagctagtc gagcagtagc tagggcagat
     3181 cgtcatatca atgaactcaa tcaagcacga aatgaagccg cttcagctcc ggctccacag
     3241 ttaccagcgc cagtaggagg agaagatgca acggtgcaaa gcccaactcc agtggctgga
     3301 aattctgttg cttctattga cgctcaattg ggtgatgccc gtgatgcgcg tgcagatgct
     3361 gcggcgcaat taagcaaggc tcaaagtcaa ttggatgcaa caactgttct cagtacccta
     3421 gagggaactg tggtcgaagt caatagcaat gtttctaaat ctccaacagg ggcgagtcaa
     3481 gttatggttc atattgtcag caatgaaaat ttacaagtca agggagaatt gtctgagtac
     3541 aatctagcca acctttctgt aggtcaagaa gtaagcttta cttctaaagt gtatcctgat
     3601 aaaaaatgga ctgggaaatt aagctatatt tctgactatc ctaaaaacaa tggtgaagca
     3661 gctagtccag cagccgggaa taatacaggt tctaaatacc cttatactat tgatgtgaca
     3721 ggcgaggttg gtgatttgaa acaaggtttt tctgtcaaca ttgaggttaa aagcaaaact
     3781 aaggctattc ttgttcctgt tagcagtcta gtaatggatg atagtaaaaa ttatgtctgg
     3841 attgtggatg aacaacaaaa ggctaaaaaa gttgaggttt cattgggaaa tgctgacgca
     3901 gaaaatcaag aaatcacttc tggtttgaca aatggtgcta aggtcatcag taatccaaca
     3961 tcttccttgg aagaaggaaa agaggtgaag gctgatgaag caactaatta gtctaaaaaa
     4021 tatcttcaga agctaccgta atggtgacca agaactgcag gttctcaaaa atatcaatct
     4081 agaagtgaat gagggtgaat ttgtagccat catgggacca tctgggtctg gtaagtccac
     4141 tctgatgaat acgattggca tgttggatac accaaccagt ggagaatatt atcttgaagg
     4201 tcaagaagtg gctgggcttg gtgaaaaaca actggctaag gtccgtaacc aacaaatcgg
     4261 ttttgtcttt cagcagttct ttcttctatc gaagctcaat gctctgcaaa atgtagaatt
     4321 gcccttgatt tacgcaggag tttcgtcttc aaaacgtcgt aagttggctg aggaatattt
     4381 agacaaggtt gaattgacag aacgtagtca ccatttacct tcagaattat ctggtggtca
     4441 aaagcaacgt gtagccattg cgcgtgcctt ggtaaacaat ccttctatta tcctagcgga
     4501 tgaaccgaca ggagccttag ataccaaaac aggtaaccaa attatgcaat tattggttga
     4561 tttgaataaa gaaggaaaaa ccattatcat ggtaacgcat gagcctgaga ttgctgccta
     4621 tgccaaacgt cagattgtca ttcgggatgg ggtcatttcg tctgacagtg ctcagttagg
     4681 aaaggaggaa aactaagatg cagaatctga aatttgcctt ttcatctatc atggctcaca
     4741 agatgcgttc tttgcttact atgattggga ttattatcgg tgtttcatca gttgttgtga
     4801 ttatggcttt gggtgattcc ctatctcgtc aagtcaataa agatatgact aaatctcaga
     4861 aaaatattag cgtctttttc tctcctaaaa aaagtaaaga tgggtctttt actcagaaac
     4921 aatcagcttt tacggtttct ggaaaggaag aggaagttcc tgttgaaccg ccaaaaccgc
     4981 aagaatcctg ggttcaagag gcagctaaac tgaagggagt ggatagttac tatgtaacca
     5041 attcaacgaa tgccatcttg acctatcaag ataaaaaggt tgagaatgct aatttgacag
     5101 gtggaaacag aacttacatg gacgctgtta agaatgaaat tattgcaggt cgtagtctga
     5161 gagagcaaga tttcaaagag tttgcaagtg ttattttgct agatgaggaa ttgtccatta
     5221 gtttatttga atctcctcaa gaggctatta acaaggttgt agaagtcaat ggatttagtt
     5281 accgggtcat tggggtttat actagtccgg aggctaaaag gtcaaaaata tatgggtttg
     5341 gtggcttgcc tattactacc aatatctccc ttgctgcgaa ttttaatata gatgaaatag
     5401 ctagtattgt ctttcgagtg aatgatacca gtttaacccc aactctgggt ccagaactgg
     5461 cacgaaaaat gacagagctt gcaggcttac aacagggaga ataccaggtg gcagatgagt
     5521 ccgttgtatt tgcagaaatt caacaatcgt ttagttttat gacgacgatt attagttcca
     5581 tcgcagggat ttctctcttt gttggaggaa ctggtgtcat gaacatcatg ctggtttcgg
     5641 tgacagagcg cactcgtgag attggtcttc gtaaggcttt gggtgcaaca cgtgccaata
     5701 ttttaattca gtttttgatt gaatccatga ttttgacctt gttaggtggc ttaattggct
     5761 tgacaattgc aagtggttta actgccttag caggtttgtt actgcaaggt ttaatagaag
     5821 gtatagaagt tggagtatca atcccagttg ccctatttag tcttgcagtt tcggctagtg
     5881 ttggtatgat ttttggagtc ttgccagcca acaaggcatc gaaacttgat ccaattgaag
     5941 cccttcgtta tgaatgagat caacaagatg gacactcgtc tatcttgttt ttgtatggat
     6001 ttccctatcg aaattcatta aaaatgtgat ataatgaagt gttagaaaaa caggtttcat
     6061 ttgcctggaa aggaaaaatt atgtctgaaa aaaattttta tattacaacg ccgatttact
     6121 atccatctgg gaaacttcat atcggttctg cctacacaac tatcgcatgt gatgtcctag
     6181 cacgttacaa acgcctgatg ggctacgatg tattttatct gacaggtctt gatgaacatg
     6241 gtcagaaaat ccagcagaaa gcggaagaag ctggtattac acctcaagcc tatgttgatg
     6301 gaatggcggt tggagttaaa gaactctggc aattactaga tatctcatac gataaattta
     6361 tccgtacaac cgatgactac catgaaaaag ttgtcgcaca ggtctttgaa cgcttacttg
     6421 ctcaagatga tatctacttg ggtgaatact ctggttggta ttcagtatca gacgaagaat
     6481 tctttacaga aagccagctg gcagaagttt tccgtgatga agctggaaat gtgactggtg
     6541 gtattgctcc atcaggtcat gaggttgaat gggtttctga agaatcatac ttccttcgcc
     6601 ttagcaaata ccaagaccgt ttggtcgaat ttttcaaagc tcatcctgaa tttatcacgc
     6661 cagatggtcg ccttaatgaa atgctacgca acttcatcga gccaggcttg gaagatttgg
     6721 cggtatctcg tacaaccttt acatggggag tgcctgtccc atcaaatcca aaacacgttg
     6781 tctacgtttg gattgatgcc cttcttaact atgcgacagc tcttggctac gctcaagacg
     6841 aacatggtaa ctttgacaag ttctggaatg gaacagtctt ccatatggta ggaaaagata
     6901 tccttcgctt ccactctatc tactggccaa tccttcttat gatgttggat gttaaattac
     6961 ctgatcgttt gattgcccat ggttggtttg tcatgaaaga cggaaaaatg tctaagtcaa
     7021 aagggaatgt cgtttaccct gaaatgttgg tagagcgtta tggactagat ccacttcgtt
     7081 actacctcat gcgtaacctt ccagttggtt cagacggaac ctttactcct gaagactatg
     7141 tcggccgtat caactatgaa ttggctaatg accttgggaa cctccttaac cgtacggttt
     7201 ccatgattaa taagtacttt gatggacaaa tccctgccta tgtagaaggt gtgactgaat
     7261 ttgatcatgt tcttgctgag gttgcagaac aatcaatcgc agacttccat acacacatgg
     7321 aagcagttga ctatccacgt gcgcttgaag cagtctggac tctgatctct cgtaccaata
     7381 aatacatcga tgagaccgca ccatgggtct tggccaagga tgaagctctt cgtgaccaat
     7441 tggcaagtgt catgagccac ttggcagcca gcattcgtgt agttgctcac ttgattgaac
     7501 catttatgat ggaaactagt cgtgcagttt tgactcaact tggtttggaa gaagtttcta
     7561 gtcttgaaaa cttgagtttg gctgacttcc cagcagatgt gactgtagtt gccaaaggaa
     7621 cacctatctt tccacgtcta aatatggaag aagaaatcgc ctatatcaag gaacaaatgg
     7681 aaggcaataa accagcagtc gaaaaagaat ggaatccgga cgcagttgag ctcaaactaa
     7741 acaaggatga aatcaagttt gaagactttg acaaggttga aatccgtgtc gcagaagtca
     7801 aagaagtgtc taaagtagaa ggttcagata agttgcttca attccgcttg gatgctggtg
     7861 atggagaaga tcgtcagatt ctttcaggaa ttgcaaaata ctatccaaat gaacaagaat
     7921 tggtcggcaa gaaagttcaa atcgttgcta acctcaaacc acgtaaaatg atgaaaaaat
     7981 atgtcagcca gggtatgatt ctctcagctg aacatgatgg caaattaacc cttctcacag
     8041 ttgatccagc tgtaccaaat ggaagtgtga ttgggtaaaa gtagacagga ctagttcaga
     8101 ctagttctgt ttttttattt atactcaatg aaaatcaaag agcaaactag gaagctagcc
     8161 gcaggttgct caaaacactg ttttgaggtt gtagatagaa ctgacgaagt cagctcaaaa
     8221 catg
//
LOCUS       DAVHSO010000082         7483 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.083, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000082 DAVHSO010000000
VERSION     DAVHSO010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7483)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7483)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7483
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.083"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(201..1592)
                     /gene="argH"
                     /locus_tag="VVR18_002029"
     CDS             complement(201..1592)
                     /gene="argH"
                     /locus_tag="VVR18_002029"
                     /EC_number="4.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001107608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HEU6033488.1"
                     /translation="MAKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAH
                     VQMLGQTGILSLEESEKIQVGLKELLEELEAGQLDFDIANEDIHMNMEVLLTEKIGPL
                     AGKLHTARSRNDQVATDMHLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHL
                     QHAQPISFAHHLMAYYNMFQRDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDL
                     LEFKQPYTNSLDAVSDRDFILEFLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTF
                     TIGSSIMPQKKNPDMAELIRGKTGRVYGHLFGLLTVMKSLPLAYNKDLQEDKEGMFDT
                     VETILNSLDVLAGMLSSLQVNKEKMQESTEKDFSNATELADYLAGKGLPFREAHEVVG
                     RLVLDSIKSAKNLQDWTLEELQTYHSLITEDIYVYLQPKTAVQRRNSLGGTGFDQVEY
                     QIAVAKKANEAKK"
     gene            complement(1621..2818)
                     /locus_tag="VVR18_002030"
                     /pseudo
     CDS             complement(1621..2818)
                     /locus_tag="VVR18_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031904.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase"
     gene            complement(2835..3641)
                     /locus_tag="VVR18_002031"
     CDS             complement(2835..3641)
                     /locus_tag="VVR18_002031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEU6033489.1"
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVAL
                     NPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKAD
                     LAISGVSKTDERSKVFDFSIPYYTAKNKLIVKKSDLTTYQSVNDLAQKKVGAQKGSIQ
                     ETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVSKGFVENNPDLAIADLNF
                     EKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK"
     gene            complement(3848..4489)
                     /locus_tag="VVR18_002032"
     CDS             complement(3848..4489)
                     /locus_tag="VVR18_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033490.1"
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLL
                     NLLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLML
                     ALKYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLIL
                     ADEPTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK"
     gene            complement(4486..6594)
                     /locus_tag="VVR18_002033"
     CDS             complement(4486..6594)
                     /locus_tag="VVR18_002033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU6033491.1"
                     /translation="MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDL
                     YLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLD
                     FTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEM
                     DKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQP
                     MMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPML
                     WLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTAL
                     LIGVGRSLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFY
                     QDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTG
                     IKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFP
                     YSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKL
                     SDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRD
                     IITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVL
                     GLASRMEKRSLVELLKGGIL"
     gene            complement(6646..6933)
                     /locus_tag="VVR18_002034"
     CDS             complement(6646..6933)
                     /locus_tag="VVR18_002034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001230165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEU6033492.1"
                     /translation="MRKLVKIGVASLMVCGILATTNALAVWVEGGQWNYGVGWTGTFG
                     YSDYLHSTRYHTATVRHGGRTSKDYAKPEAWARASLTKIPPTGMEYFYGFE"
     gene            7359..>7483
                     /locus_tag="VVR18_002035"
     CDS             7359..>7483
                     /locus_tag="VVR18_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU6033493.1"
                     /translation="MQRLEVYKNYQRLYDLRIAILLNLSTLYLYNQDKNMCKQIC"
BASE COUNT         2277 a         1699 c         1221 g         2286 t
ORIGIN      
        1 ctgccaagcc acatagtgtg tttactacta tgtgtccatg tcaccatgaa tcgccgaacg
       61 atttaacgag aaagtatgac ttttacgttt atcccaactc aattatgaca tttttttcaa
      121 aagtcaatat atctcacttt ttcaacgaca agaaagaggc tgccaatcga ccaacctctt
      181 attctgaacc catcactcca tcacttttta gcttcattcg ctttcttagc gactgcaatc
      241 tggtattcga cttggtcaaa ccctgtgcct cccaaggaat ttcgtctttg aacagcagtt
      301 ttaggttgca agtagacata gatatcctcg gtaatgagag aatgataggt ttgtaattcc
      361 tccaaagtcc aatcttgaag atttttagca gacttgatag agtctagcac taatcttccc
      421 acaacctcat gagcttctct aaatggcaag cctttccctg ccaaataatc tgccaactca
      481 gttgcatttg aaaagtcctt ctctgttgat tcttgcattt tttccttgtt tacctgcaaa
      541 ctagataaca tacctgccaa cacatcgagg gaatttaaaa tcgtttcgac cgtatcaaac
      601 attccttcct tatcttcttg caaatcctta ttataagcta aaggcaagga cttcatgact
      661 gtcaacagtc caaacaaatg cccataaact ctgccagtct ttcctcgaat caactcagcc
      721 atatctggat ttttcttttg gggcataata gaggaaccta ttgtaaacgt atctgacaag
      781 gtaatgaatt ggtactcaaa actacaccaa ttaatcattt cttcgcaaaa acgactcata
      841 tgcatcatga gtatgctggc atttgataga aattctaaga taaaatcgcg gtcactaaca
      901 gcatccaaag aatttgtata aggttgctta aactccagca aatcgctaga caattggcga
      961 tcaatgggga aagtcgttcc tgccaaagct gccgcaccta aagggcatag gtctgtatgc
     1021 ttctggttaa attcaaaacg ttcactgtct ctttgaaaca tattgtagta agccatcagg
     1081 tggtgggcaa aactaatagg ctgggcatgt tgcagatggg tatagcccgg catgatcgtc
     1141 gccacatgat tttccgccaa gtctaataaa acacccttaa gatgagccag tttatctagg
     1201 acatagccta gttgttcctt gagatacaag tgcatatctg tcgcaacttg gtcatttcga
     1261 gaacgagccg tatgtaactt ccctgcaagg ggaccaattt tttctgtcag caacacttcc
     1321 atattcatat gaatatcttc gtttgcgata tcaaagtcaa gttgacctgc ctctagctct
     1381 tctaaaagct ctttcaagcc tacttgaatc ttttctgact cctccaaact caaaatgccc
     1441 gtctgaccca acatctgaac gtgggctaaa gaaccaatca catcaaattt agctaatttc
     1501 tggtcaaaag atatactcgc accaaagcgc tctacccagt cttcgacagt accttcaaag
     1561 cgaccacccc ataattttgt attcttagcc atatcacatc cacctctcta tccaatcgtc
     1621 ctatttggcg cttttttgaa cctcagaatg aaccttggtt ggaagtcccc ataactcaat
     1681 aaagccaaca gccgcatctt ggtcaaaggt atctgcacta gtatacgtcg ccaaattttc
     1741 atcgtaaaga gaatttggtg atttccgagc cacgacctga gcactccccc ttatacagtt
     1801 tgacttttgc agtcccattg acaacttttt gagtctcttt aatataagca atcaaggctt
     1861 gtgtagccga actaaaccac aaagcattat aaatgagatt tgataattca ttttctatga
     1921 ttggtttaaa atgagccact tctctcacaa gcgtcaagtc ctcaatttcc ttatgagctg
     1981 tcagcagggt cactgcacct ggacactcat agatttctct tgatttaatc ccaaccaagc
     2041 gattttccac gtggtcaatc cgtccaaccc catgttttcc agctatttca ttgagttttt
     2101 gaatcaaatc tgccaatttt aacacttctc cattgaggga aactggaaca ccttcactaa
     2161 actcaatctc aatgtattct ggcatatctg gagcttgctc tggagaagtt gtgatgccaa
     2221 aggcttcttc tggagcctga ttccatggat tttccaaaat accacactca ttggcacgtc
     2281 cccaaagatt ttggtcgaca gagtagggat tgtcaaggtc agcaggaaca ggcaccccat
     2341 ttttcttggc ataataaatt tcttcctccc gagaccattt ccattcacga actggagcaa
     2401 tcacttttaa attgggatcc aaggctgcaa tcgatacttc aaaacgtact tggtcattcc
     2461 ccttaccggt acaaccatga gcaattgtag tcgctcctat ctgatgcgct atttcaacca
     2521 attttttaga aataagaggg cggctcaagg cagataccaa ggggtacttt tgttcataat
     2581 aggcatgtga ctgaagagcc actagcacat aatctgtagc aaattcgtcc ttgacatcaa
     2641 tgacataaga ttcgactgcc ccaaccttga gagccttatc atggatgaag tctaagtctt
     2701 tcccttcacc cacatccata caaactgaaa caacatcata gtctttcttt aaccaggtaa
     2761 tagcaactga tgtgtccaaa ccgccagaat aggccaaaat tactttttct ttactcatgt
     2821 tcttttcctt ctttctattt ttcaatggat gctttaaagg catcctcaat gagtttgtct
     2881 aattccccag actccttcaa cttttgaatg gttttatcga ctgcctcttt caattccttg
     2941 ctatcttttt tcatggctac cgcgtaggaa tcatcttgct ctttttcaaa attgaggtct
     3001 gcgattgcta aatcaggatt attttccaca aatcccttgg aaacaggttc ttcaaagata
     3061 acggcatcca cttgtcctga ttttaaatct gtgattaaat tcccattttt aggcagagat
     3121 acgagggaag aattttgtag caaatctttc gccatcgtct cttgaatcga acctttctgc
     3181 gctccaacct ttttctgcgc caagtcgttt acagactgat aagtagtcaa gtcagatttt
     3241 ttgacaatga gtttattttt tgcagtatag tagggaatgg aaaagtcaaa caccttgctc
     3301 cgttcatctg tcttagaaac acctgatatg gcaaggtcgg cttttcctga ttgaacacta
     3361 gccagtacat tatcaaaact catgggagat agttccaatt cgacacctag ttctgttgcg
     3421 atagccttgg ctaattcgat atctgaaccc acaatctgat ttttcccatc aaccactttt
     3481 tggtattcaa atggagcaaa atctggattg agggctacaa ccaattttcc tttggacttg
     3541 atggcttcaa ttccagccga ttgattgttg ctacaagcaa atagtagggg gagcatcact
     3601 aaaccaaaca tcgtcatcaa caccttcttc atcttattca taacaaagtc tcctttatgt
     3661 ttattctttt tggttgtata aataatactc ccatactcat cctttgtcaa gcctaaattg
     3721 aaaaaatttt caatttgaaa caaaaaaaac ctagaaatac tacataaaat gtcattccta
     3781 ggcgtattta tgctattttt ctctggaaaa catgagtatt cagccagtca aaaggagctg
     3841 aatgaactca ttttccctcg cccaattcaa tgacacgatg acattgttgg gctacataag
     3901 catcgtgggt cacaataatg actgttttcc cttctcgatt catctctaag agaaacttca
     3961 agaccaaatc tctattttca ggatccagcg aacctgtagg ttcatcggct aaaatcagct
     4021 ggctgggttt taagatggct ctagcaactg caattcgttg ttgttcgccc ccagacaact
     4081 cggagaccct ttgatgcaaa gtagctgaca aacctactct ctctaaaatc tcttccacct
     4141 ttttgagctt gtctttctta ggcaatttca catatttcag cgccagcatg agattgtact
     4201 cgaccgtttc atcatcaatc agggcaaaat tttgaaacag ataagagata tgttcacgga
     4261 ttattgtttg cgacttagca gaattaaccg ctagatttgt ctgaccaaaa atctcatacc
     4321 gtccgctata atcaccatct atcaaaccca ataaatttaa caaggtcgac ttcccactac
     4381 cactcttacc aacaatagct accaaatccc cctgatcaat cctgagagat aagttatcca
     4441 aaatcacttt tcccccaatg gttttggtaa tatttttcaa ctcaatcata agatgccccc
     4501 tttcaataac tctactagac ttcttttctc catcctagaa gctaagccta gcacaaatag
     4561 tatatccaga catgtaaaac ctgcaaacag tagaagtggt aagaacgcat gggcaaagaa
     4621 aatcaagact agaagaggga aactatagcc cagcaagagc agaacgagga gaggacggta
     4681 gcgatcgacc agtttccacc ccataaactt cttggtaatg atatccctgc gcttcaataa
     4741 gaaagttgtt actagtaaga agtaggaaat catcatgcta aggagaccaa acaaagcaaa
     4801 gagtaggtta aaattccgaa cagcatctct ataagaatcc actttctctt gttgaatggc
     4861 ttgaatagat gaaaatttta aataatttcc atctgacaat ttctcaacta actctgtaat
     4921 ctctttttga tgttgaaccg tattttcaat tttaatcgga ttatttaagc cagttgttga
     4981 cagggaggct ttctcatccc acatcatatc agaatcattg accaagctaa taattggatt
     5041 ggagagattt tcctttcgct tatcactata tgggaaaaat gaccaatctc cttcataata
     5101 ggcaatctcg acatccatct cctctatcgt tcgtttttgc tgctcttcat acttcatcga
     5161 atgaaaggca attaacttcc ccaagagctg atttttatct tcttcacctt tcgtacttgc
     5221 tggcatcaaa ataacttttt taataccggt atctggtagc ttgaatccct tgctctttag
     5281 aaaattgcga ttggcatagt aaacatccac cgtatctgtt aactgatatt gctgaatctg
     5341 ttctgattgg acaaaatttt ttacaggaag actgctactc tgcacatagc ccgcctgcgt
     5401 tttttctacc aaatcctgat aaaatcgata gaaataatct gtagatttcc ctgaccctgc
     5461 tagctcttct tgccacagat tatcattgag tttgaaggtt tctaaggtca ggtaattacc
     5521 ttgacttacc cactgttgct gataagcaag ttctttgttt tcttgttcta aacttctgcc
     5581 caccccaatc agtaaggccg tcagtaaaat agttgtccct attttcatca cataattgaa
     5641 gataagacca aatttgaaag atgaaaaacc tttcagcaga gagctgattg tcattttttg
     5701 gattaagagg taagtcaacc aactgataaa gagataaagc tgcaacagca aaaaatgaga
     5761 caaccacagc ataggaaaca aatcttttgg cttataatca agcaagaaaa acacgcctag
     5821 attgatcaca agagccccac ctaggaggag gtaaaggttg ccttttacaa catcagctaa
     5881 aacagcccta tcttgaaaac caagtaattt ttgtacccca actcttttca tctccatcat
     5941 cggttgatac actgtcacta acacaagaag caaaatagcc aagacaaaaa caatggcaga
     6001 taaaagcaaa tctcgattta tgacttccac tgcacttttg taggtcggct ctagcaaggt
     6061 agcctggtct atcttgaaaa aatcgctcca tttctgtaca atcctatcct tgtccatctc
     6121 ttgtgtagaa gttatcgtat agcgaccatt taaactacga gatgtatcct tgatataggt
     6181 ttgaaaagtc ataagctgaa taggtttggc ttttagaaag gtcggaatcg taccaagttt
     6241 attggaaatt tctttattac tatagactcc ttcaccatct gtggtaaaat caagagaaga
     6301 aatcccaaac tcttggtagg ggaaggtatc tttatcaaaa acaccagact tgaccacctc
     6361 atcaccactg tctgttttga tgatggagac tttatactcc tttgatacat cctcaaaaaa
     6421 tcgaagaaca gacgctgcag gttcgttaat atctttcaaa tacaaatcca aagaatctac
     6481 agtctttccc atttcttgaa tccgaaccac ttctcgtgta tagtttacat taaaaacaaa
     6541 aaaagtggta cacagaagca ggagtaacat acagaaatta ctgatttttt tcataaaagt
     6601 gcctccacta cagttttccc tctccaaata ggagagggaa gaattttact caaatccata
     6661 gaaatattcc attcctgttg gcggaatctt ggtgagggaa gctctagccc atgcctcagg
     6721 ttttgcataa tccttagagg ttctaccccc atgtctaaca gttgctgtat gatatcgagt
     6781 agaatgtaag taatcagaat atccaaaagt tcctgtccaa cctactccat agttccattg
     6841 accaccctca acccatactg ctaaagcatt tgtagtagca agtataccac ataccattaa
     6901 agatgcaaca ccaattttaa ctaattttct catgatttat ttctcctatt atcgagagct
     6961 gttccgtaaa aacagctata gtaatttatc aacaagtatc gtagtccatt ggactcacct
     7021 tccttctatc tcatttcatt tttaaacaac gaacttactc ttaactagaa gaatagttct
     7081 cttctgtatc aggtctttga acaaccagag tagtattaat cacactctaa ctattactca
     7141 agaatcagcc caataaacaa catggatagc gctttcaaat ttttaaactc ttatcccatc
     7201 cttttatcta tataataagt gaaaatataa taactgtcaa gtaatcgaag taaattttat
     7261 aaaaaaaatt acaagccaaa tttgtaaagt ttacactaag ccgctagggc aatcgtctat
     7321 cagaatgtcc gtttatttgt caataatccg agaaaatctt gcaacgctta gaagtctata
     7381 aaaactatca acgtttatat gacttgcgaa tagcaatcct gctcaacctt tccacactct
     7441 atctatacaa tcaagataaa aacatgtgta agcaaatctg cta
//
LOCUS       DAVHSO010000083         7056 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.084, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000083 DAVHSO010000000
VERSION     DAVHSO010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7056)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7056)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7056
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.084"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..483
                     /locus_tag="VVR18_002036"
                     /pseudo
     CDS             1..483
                     /locus_tag="VVR18_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="internal stop; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            544..1506
                     /locus_tag="VVR18_002037"
     CDS             544..1506
                     /locus_tag="VVR18_002037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEU6033494.1"
                     /translation="MNMSNITIDGQEMDLSQTMPSYAQVVSLYEDTSISVSSNETDKV
                     LAGSLYTDTNEQGLTIPSSLLKNWNEQTGKNLTANDLIGKSVSASIVESAAEASKIAQ
                     FQTKIVRVINDEDDMEDSNSFMLSHQMETILKEAGFMKAVSYFILELKDPSQTKVVTE
                     ELQKNKKYTVLSQQRVLDIVITFIRVIQGLLIVLSSQAIVVAAVMIGIIIYINIMQRS
                     KEIGVMKAVGYQNRDVKGIFIYEAIWIVGIALLLAFLVAQGVGSLANAIVSHFYPSIT
                     KVFELNLLSVLGTLVFALLLGYVSAYFPARKISKMDPVESLRYE"
     gene            1683..2690
                     /gene="gap"
                     /locus_tag="VVR18_002038"
     CDS             1683..2690
                     /gene="gap"
                     /locus_tag="VVR18_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HEU6033495.1"
                     /translation="MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHL
                     LKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDPEQIDWATDGVEIVLEATGFFAK
                     KEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHNVLDGTETVISGASCTTNCLAPMA
                     KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIG
                     LVIPELNGKLDGSAQRVPTPTGSVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDP
                     IVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIA
                     K"
     gene            complement(2758..3594)
                     /locus_tag="VVR18_002039"
     CDS             complement(2758..3594)
                     /locus_tag="VVR18_002039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000216776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEU6033496.1"
                     /translation="MTVKQLLEEQLLIPRKIRHFLRIKKHILINQEEVHWNEIVNPGD
                     VCQLTFDEEDYSQKTIPWGNPDLVQEVYQDQHLIIVNKPEGMKTHGNQPNEIALLNHV
                     STYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLEKKEISREYWALVDGNINRK
                     ELVFRDKIGRDRHDRRKRIVDAKNGQYAETHVSRLKQFSNKTSLAHCKLKTGRTHQIR
                     VHLLHHNLPILGDPLYNSKSKTSRLMLHAFRLSFTHPLTLERLTFTTLSNTFEKELKK
                     NG"
     gene            3720..5915
                     /locus_tag="VVR18_002040"
     CDS             3720..5915
                     /locus_tag="VVR18_002040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEU6033497.1"
                     /translation="MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGP
                     IRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKE
                     AGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGS
                     TITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVE
                     DASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLKNMVAAGYI
                     DKNQETEAAEVDMTSQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYR
                     IYTELDQNYQANMQIVYENTSLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDK
                     TGFRNFNYATQSKRSPGSTIKPLVVYTPAVEAGWALNKQLDNHTMQYDSYKVDNYAGI
                     KTSREVPMYQALAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGV
                     ETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIASHKNSQKRVIDKSVADKMTS
                     MMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFP
                     TTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTFTVENAYKQNGIAPANTKRQVQT
                     NDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR"
     gene            5968..6120
                     /gene="rpmG"
                     /locus_tag="VVR18_002041"
     CDS             5968..6120
                     /gene="rpmG"
                     /locus_tag="VVR18_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEU6033498.1"
                     /translation="MALKKASLACAVCGSRNYSIKISGNPKPTRLEVNKFCKHCGKYT
                     THRETR"
     gene            6130..6306
                     /gene="secE"
                     /locus_tag="VVR18_002042"
     CDS             6130..6306
                     /gene="secE"
                     /locus_tag="VVR18_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HEU6033499.1"
                     /translation="MRFIGDIFRLLKDTTWPTRKESWRDFRSIMEYTAFFVVIIYIFD
                     QLIVSGLIRFINIF"
     gene            6361..6897
                     /gene="nusG"
                     /locus_tag="VVR18_002043"
     CDS             6361..6897
                     /gene="nusG"
                     /locus_tag="VVR18_002043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusG"
                     /protein_id="HEU6033500.1"
                     /translation="MDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIP
                     TQTVQVEKNGKRKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPT
                     PLLEQEIRDILVSMGQTVQEFDFDVEIGQTVRIIDGAFADYTGKITEIDNNKVKMIIS
                     MFGNDTVAEVNLNQIAEL"
BASE COUNT         2199 a         1222 c         1533 g         2102 t
ORIGIN      
        1 aattttaata gtttaaagca cctagcacct gtttagattg atgaaacagg attcgatact
       61 tatttttatc gagaatatgg tcgctcatta aaaggtcagt taataagagg taaagtatct
      121 ggaagaagat atcagaggat ttctttggtt gcaggtctaa caaatggtga gttaatcgct
      181 ccaatgactt acgaagagac gatgacgagc gacttttttg aagcttggtt tcagaagttt
      241 ctcttaccaa cattaaccac accatcggtt attattatgg ataatgcaag attccataga
      301 atgggtaagt tagaactttt atgcgaggag tttgggcata aacttttacc tcttcctccc
      361 tactcacctg agtacaatcc tattgagaaa acatgggctc atatcaaaaa gcacctcaaa
      421 agggtattac caagttgcaa taccttttat gaggctcttt tgtcttgttc ttgtttcaat
      481 tgactatagt tcacggatac agttgggaaa gaagctatta aacatttgga gagtcctttt
      541 gggatgaaca tgtcaaatat tactatagat gggcaagaaa tggatctgag tcaaacgatg
      601 ccttcttatg ctcaagtagt gagtctttat gaggatacaa gcatctctgt tagtagtaat
      661 gagacggaca aagtgttggc tggatccctc tatactgata caaatgaaca gggattaacg
      721 attccaagca gtttactaaa aaattggaat gaacagacag gaaaaaattt gacagctaat
      781 gatcttattg gcaaatcagt ctcagccagc attgtagaaa gtgctgccga agctagtaag
      841 attgctcaat ttcaaacgaa gattgtacgt gtaatcaatg atgaagatga catggaggac
      901 agcaacagtt tcatgctgtc tcatcaaatg gaaacgattt tgaaagaggc tggatttatg
      961 aaagctgtat cttattttat cttggaactc aaagatccat cacagacaaa agtagtaaca
     1021 gaagaattac agaaaaataa gaagtatact gtgctttctc aacagagagt tcttgatatt
     1081 gtgattacct ttattcgtgt tattcaggga ttattgattg tgctttcatc acaagctatt
     1141 gtggtagcag cggttatgat tggtattatt atttacatca atatcatgca acgttccaag
     1201 gaaataggtg tcatgaaagc agttggttat cagaatcgtg atgtcaaagg aatttttatt
     1261 tacgaggcta tctggattgt aggcatcgcc ttgctgctgg catttttggt tgcacaaggg
     1321 gtgggaagtt tggcgaatgc gattgtaagt cacttttacc catccatcac taaggttttt
     1381 gaattaaatc ttttatctgt tttaggaact ctagttttcg ctctattact tggttatgtc
     1441 tcagcctact tcccggcacg taagattagt aaaatggatc ctgtagaatc gttacgctat
     1501 gaatagtaag ggattccttg atttacagtc ttaaaaagaa actaacatag aaaaacaatg
     1561 gccatacttg caattcaact caaatagttg tataataggt ttgttgaaag gtgatttgta
     1621 gtgattcaag ttactctttt cacaataaaa atttcatgat tttcataagg aggaaatcac
     1681 taatggtagt taaagttggt attaacggtt tcggacgtat cggtcgtctt gctttccgtc
     1741 gtatccaaaa cgtagaaggt gttgaagtta cacgcatcaa cgaccttaca gatccagtta
     1801 tgcttgcaca cttgttgaaa tacgacacaa ctcaaggtcg tttcgacggt actgttgaag
     1861 ttaaagaagg tggatttgaa gttaacggta aattcatcaa agtttctgct gaacgtgatc
     1921 cagaacaaat cgactgggct actgacggtg tagaaatcgt tcttgaagct actggtttct
     1981 ttgctaagaa agaagcagct gaaaaacacc ttaaaggtgg agctaaaaaa gttgttatca
     2041 ctgctcctgg tggaaacgac gttaaaacag ttgtattcaa cactaaccac aacgttcttg
     2101 acggtactga aacagttatc tcaggtgctt catgtactac aaactgcttg gctccaatgg
     2161 ctaaagctct tcaagacaac tttggtgttg ttgaaggatt gatgactact atccacgctt
     2221 acactggtga ccaaatgatc cttgacggac cacaccgtgg tggtgacctt cgccgtgctc
     2281 gcgctggtgc tgcaaacatc gttcctaact caactggtgc tgcaaaagct atcggtcttg
     2341 taattccaga attgaatggt aaacttgacg gatctgcaca acgcgttcca actccaactg
     2401 gatcagttac tgaattggta gcagttcttg aaaagaacgt tactgttgat gaagtgaacg
     2461 cagctatgaa agcagcttca aacgaatcat acggttacac agaagatcca atcgtatctt
     2521 cagatatcgt aggtatgtct tacggttcat tgtttgacgc aactcaaact aaagttcttg
     2581 acgttgacgg taaacaattg gttaaagttg tatcatggta cgacaacgaa atgtcataca
     2641 ctgcacaact tgttcgtact cttgaatact tcgcaaagat tgctaaataa ttcttgagtt
     2701 gatagaaagc aaggctttgt ggtcttgctt ttttatatgg aaaaatggat gacacgatca
     2761 tccattcttt tttaattctt tttcaaatgt atttgaaagg gtagtgaaag ttagcctctc
     2821 taaagtaagt gggtgggtaa aggaaagtcg gaaggcatga agcataagcc ggcttgtctt
     2881 tgatttacta ttatagagag ggtctcccag gataggaaga ttatgatgca aaaggtgcac
     2941 acgaatctga tgggttcgcc ctgtctttag cttgcaatga gccaaggaag tcttgtttga
     3001 gaattgcttt aatctgctta catgcgtttc agcatattgc ccattttttg catcaactat
     3061 tctttttcta cgatcatggc gatcacgtcc aattttgtct ctgaaaacaa gttcttttct
     3121 gttgatattt ccatcaacta gagcccaata ttctctagaa atctcttttt tctccaataa
     3181 gcgattgaga atgggcagga taaaaggatt tttggcaaag agaactaagc cactggtttc
     3241 catgtccaga cgatgaacga catagcaggt ttggccaaca taggtactga catggttaag
     3301 aagggcaatt tcgtttggtt gattaccatg cgttttcatc ccctctggtt tgtttacaat
     3361 aatcaagtgt tgatcttgat aaacttcctg cactaagtct gggttgcccc aagggatcgt
     3421 cttttgggaa taatcttcct cgtcaaaagt caactggcaa acatctccag gatttacgat
     3481 ttcgttccag tggacttctt cttgatttat caaaatatgt ttcttgattc tcaaaaaatg
     3541 acggattttt ctagggatga ggagttgttc ctcaagtaat tgctttaccg tcatttgagg
     3601 tagagaggcg ggtaatgtaa atgtgaattg catacagata ttgtaacaaa aaaagcccta
     3661 tttggatagg aaatagctaa attcttgtct tcctatgatg aagatgataa aataaacgca
     3721 tgaaattaga taaattattt gagaaatttc tttctctttt taaaaaagaa acaagtgaac
     3781 tagaggactc tgattctact atcttacgtc gctctcgtag tgatcgaaaa aaattagccc
     3841 aagtaggtcc gattcgaaaa ttctggcgtc gttatcatct aacaaagatt atccttatac
     3901 taggtttgag tgcaggcttg ctagttggaa tctatttgtt tgctgtagcc aagtcgacca
     3961 atgtcaatga tttgcaaaat gccttgaaaa ctcggactct tatttttgac cgtgaagaaa
     4021 aagaggctgg tgccttgtct ggtcaaaagg gaacctatgt tgagctgact gacatcagta
     4081 aaaacttgca gaatgctgtt attgcgacag aagaccgttc tttctataaa aatgacggga
     4141 ttaactatgg ccgtttcttc ttggctattg tcactgctgg acgttcaggt ggtggctcta
     4201 ccattaccca acagctggct aaaaacgcct atttatcgca ggatcaaact gttgagagaa
     4261 aagcgaaaga atttttcctt gccttagaat taagcaaaaa atatagtaag gagcaaattc
     4321 taaccatgta ccttaacaac gcttattttg gaaatggtgt gtggggtgta gaagatgcga
     4381 gtaagaaata ctttggagtt tctgcatcag aagtgagtct ggatcaagct gcgactctgg
     4441 cagggatgct caaggggccg gaactgtata atcccttgaa ttccgtagaa gattctacta
     4501 atcggcgcga tactgtcttg aagaatatgg ttgcagcagg atatattgat aaaaaccaag
     4561 aaaccgaagc tgctgaagtt gatatgactt cgcaattgca cgataagtat gaaggaaaaa
     4621 tctcagatta ccgttacccc tcttattttg atgcggtggt taatgaagct gtttccaagt
     4681 ataatctaac agaggaagag attgtcaata atggctaccg catttacaca gagctggacc
     4741 aaaactacca agcaaatatg cagattgttt atgaaaacac atcgctattt ccgagggcag
     4801 aggatggaac gtttgctcaa tcaggaagtg tagctctcga accgaaaaca gggggagttc
     4861 gtggagttgt cggtcaagtt gctgacaatg ataaaactgg attccggaat ttcaactatg
     4921 caacccaatc aaagcgtagt cctggttcta caattaagcc tttagttgtt tatacgccag
     4981 cagttgaagc aggctgggct ttgaataagc agttggataa ccataccatg cagtatgaca
     5041 gctataaggt tgataactat gcagggatca aaacgagtcg agaagttcct atgtatcaag
     5101 ccttggcaga atcgcttaat ctacctgctg ttgccactgt taatgatttg ggtgtcgaca
     5161 aggcttttga ggcaggcgaa aaattcggac tcaacatgga aaaggtcgac cgtgttcttg
     5221 gtgtcgcctt gggaagcggt gttgaaacca accctcttca aatggctcaa gcatacgccg
     5281 cctttgcaaa tgaaggttta atgcctgaag ctcattttat tagtagaatt gaaaatgcta
     5341 gtggacaagt tattgcgagt cataaaaatt cacaaaaacg ggtgattgat aagtctgtag
     5401 ctgacaagat gaccagtatg atgttgggga ctttcaccaa cggtaccggt attagttcat
     5461 cgcctgcaga ctatgtcatg gcagggaaaa ctggaacaac tgaagcagtt ttcaatccgg
     5521 agtacacaag tgaccagtgg gtaattggtt atactccgga tgtagtgatt agccactggc
     5581 ttggctttcc gaccactgat gaaaaccact atctagctgg ctctacttca aacggtgcag
     5641 ctcatgtctt tagaaacatt gccaatacca ttttacctta tacgccagga agtaccttta
     5701 cggttgaaaa tgcttataag caaaatggaa ttgcaccagc caatacaaaa agacaagtac
     5761 aaaccaatga taatagccag acagatgata atttgtctga tattcgaggg cgtgcgcaaa
     5821 gtctagtaga tgaggctagc cgggctatct cagatgcgaa gattaaggaa aaggctcaaa
     5881 caatatggga ttcgatagtc aatctatttc gctaagatgc ttgtcaaagc ctagctttct
     5941 tgttataatg gataagatgg aggcgttatg gcactaaaaa aagcaagcct agcttgtgcg
     6001 gtttgtggtt cgagaaacta ttcaatcaag atcagcggaa accccaagcc tacacgacta
     6061 gaagtaaata aattttgtaa gcattgtggc aagtacacta cacacagaga aacgagatag
     6121 gagagagcga tgcgttttat tggagatatt tttagacttc ttaaagacac aacatggcca
     6181 actcgcaagg aaagctggag agattttcgt tctatcatgg aatacacagc tttctttgta
     6241 gtaattattt acatttttga ccagttgatt gtttcaggtt tgattcgatt tattaacatt
     6301 ttttagaaga ttagtggagt taattacact agaaatcttc tatttatgaa aggaaatatc
     6361 atggatagtt ttgataaagg atggtttgtt ttacaaactt attctggtta tgaaaataag
     6421 gtgaaagaaa atctattaca acgtgcacaa acctacaata tgttggataa tattctacgc
     6481 gttgaaattc caacacaaac agtgcaagtt gaaaaaaatg gaaagagaaa agaagtagaa
     6541 gaaaatcgct ttccaggtta tgttcttgta gaaatggtca tgacagatga agcttggttt
     6601 gttgttcgaa acacaccaaa tgttacagga tttgtcggat cacacgggaa cagatcaaaa
     6661 ccaactccat tattggaaca agaaattcgt gacattttgg tatctatggg acaaactgtt
     6721 caagaatttg atttcgatgt tgagattggt caaactgtac gtattattga tggtgctttt
     6781 gcagactaca ctggtaagat tacagaaatt gataataaca aagtgaaaat gattatctct
     6841 atgtttggta atgacacagt tgcagaagta aacctaaacc aaatcgcaga attataaccc
     6901 tgagagaggc tggagcctct cttttttgtg cagtttagga gctaaaggga acagaatgga
     6961 gaaaatggaa caaatgtgtt ttctaatctg ttagactgta tctagaaagg ggaaaattat
     7021 gattaaagaa ttgtatgaag aagtccaagg gactgt
//
LOCUS       DAVHSO010000084         6939 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.085, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000084 DAVHSO010000000
VERSION     DAVHSO010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6939)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6939)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6939
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.085"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..814
                     /locus_tag="VVR18_002044"
     CDS             <1..814
                     /locus_tag="VVR18_002044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU6033501.1"
                     /translation="LLLKAIKLARSTYYYHLKQLDKTDKDQELKAEIQSIFIEHKGNY
                     AYRRVHLELRNRGYLVNHKRVQGLMKVLNLQAKMRQKRKYSSHKGDVGKKAENLIQGQ
                     FEGSKTMEKCYTDVTEFAIPASTQKLYLSPVLDGFNSEIIACNLSTSPNLEQVQTMLE
                     QAFTEKHYENTILHSDQGWQYQHDSYHQFLEGKGIQASMSRKGNSQDNGMMESFFGIL
                     KSEMFYGYEKTFKSLNQLEQAIVDYIDYYNNKRIKVKLKGLIPVQYRTKSFG"
     gene            complement(942..1145)
                     /locus_tag="VVR18_002045"
     CDS             complement(942..1145)
                     /locus_tag="VVR18_002045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033502.1"
                     /translation="MIKLYSPYAFLSKYLGAILLSFFCYYAKEIGCSNLTLSVWNDNE
                     GALRFYQRQGMKPQETTMEMIID"
     gene            complement(1138..2220)
                     /locus_tag="VVR18_002046"
     CDS             complement(1138..2220)
                     /locus_tag="VVR18_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEU6033503.1"
                     /translation="MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFL
                     FVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFD
                     NLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
                     ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFD
                     LGVLVNGYASDMTRTVAVGKPDQFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAARE
                     VIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVR
                     IEDCGVVTKDGFDLFTSTSKDLLYFD"
     gene            complement(2346..3128)
                     /locus_tag="VVR18_002047"
     CDS             complement(2346..3128)
                     /locus_tag="VVR18_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="HEU6033504.1"
                     /translation="MVYTSLSSKDSNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAE
                     KLGAHVTVDIVSLHDDFDENHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGV
                     VLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYG
                     FENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAY
                     RLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS"
     gene            complement(3128..4471)
                     /locus_tag="VVR18_002048"
     CDS             complement(3128..4471)
                     /locus_tag="VVR18_002048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mur ligase family protein"
                     /protein_id="HEU6033505.1"
                     /translation="MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNL
                     AKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKT
                     GKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILDAIRKVPT
                     ATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNT
                     YANLGAYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALA
                     AVAIARFLGADSQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIK
                     LAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVT
                     GYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN"
     gene            complement(4570..5886)
                     /locus_tag="VVR18_002049"
     CDS             complement(4570..5886)
                     /locus_tag="VVR18_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000958936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-containing oxidoreductase"
                     /protein_id="HEU6033506.1"
                     /translation="MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCI
                     NIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNGKNYATVAGTGVDIFDAEAHFLS
                     NKVIEIQAGDEKKELTAETIVINTGAVSNVLPIPGLATSKNIFDSTGIQSLDKLPEKL
                     GVLGGGNIGLEFAGLYNKLGSKVTVLDALDTFLPRAEPSIAALAKQYMEEDGIELLQN
                     IHTTEIKNDGDQVLVVTEDETYRFDALLYATGRKPNVEPLQLENTDIELTERGAIKVD
                     KHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFIT
                     PALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGAS
                     IFSEGSQEIINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI"
     gene            6079..>6939
                     /locus_tag="VVR18_002050"
     CDS             6079..>6939
                     /locus_tag="VVR18_002050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OFA family MFS transporter"
                     /protein_id="HEU6033507.1"
                     /translation="MKSNRYIIAFAGVILHLMLGSTYAWSVYRNPIIEKTGWDQASVA
                     FAFSLAIFCLGLSAAFMGRLVEKFGPKVMGSLSAFLYAGGNILTGFAIDRQELWLLYL
                     AYGILGGLGLGAGYITPVSTIIKWFPDKRGLATGLAIMGFGFASLLTSPIAQHLIAGV
                     GIVETFYILGASYFIIMLLASQFIKRPNEQELAILSSSGKEKTASLTQGMAANQALKS
                     NRFYMLWIIFFINIACGLGLISAASPMAQEMAGLSTSHAAVMVGVLGIFNGFGRLLWA
                     SLSDYIGRPLT"
BASE COUNT         2005 a         1354 c         1518 g         2062 t
ORIGIN      
        1 tcttcttcta aaagccatta aactagctcg ttcgacctac tactatcact tgaaacagct
       61 agacaaaaca gataaggacc aagagcttaa agctgaaatt caatccattt ttatcgaaca
      121 caagggaaat tatgcttatc gtcgggttca tttagaacta agaaatcgtg gttatctggt
      181 aaatcataaa agagttcaag gcttgatgaa agtactcaat ttacaagcta aaatgcgaca
      241 gaaacgaaaa tattcttctc ataaaggaga cgttggtaag aaagcagaga atctcattca
      301 aggccaattt gaaggctcta aaacaatgga aaagtgctat acagatgtga cagaatttgc
      361 cattccagca agtactcaaa agctttactt atcaccagtt ttagatggct ttaatagcga
      421 aattatcgcc tgtaatcttt caacttcacc caacttagaa caagtacaaa caatgttgga
      481 acaggcattc acagagaagc actacgagaa tacgattctc catagtgacc aaggctggca
      541 atatcaacac gattcttatc atcagtttct tgagggtaag ggaattcaag catccatgtc
      601 acgcaaggga aacagccaag acaacggtat gatggagtcc ttctttggga ttctgaaatc
      661 ggaaatgttt tatggctatg agaaaacatt taaatcactt aatcaattgg aacaagctat
      721 tgtagactat attgattact acaacaataa acgaattaag gtaaaactaa aaggacttat
      781 ccctgtgcaa tacagaacta aatccttcgg ataaattaat tgtctaactt tttggggggc
      841 agttcattct acacccacta ttatgcgttt tattgtggga agattttcct cattttctag
      901 tgaaattgaa ctttttctaa catcttttga tagatgactt cttaatcaat tatcatttcc
      961 attgttgttt cttggggttt catcccttgt ctttgataaa agcggagagc accctcgtta
     1021 tcattccaga cacttagggt tagattactg cagccaattt ctttagcata atagcagaaa
     1081 aatgacaata aaatagcccc tagatatttt gaaaggaaag cataggggct atatagttta
     1141 atcaaaataa agcaaatctt tgctggtgct tgtaaagagg tcgaagccat ccttggtaac
     1201 aacaccgcag tcttcaatac gaacaccgac tttaccaggg atatagatac ctggttcaac
     1261 agagaagcac atgccttctt cgatgaccat gtcgtttcct tccatgatag atgggaattc
     1321 atggacatcc ataccgatac catgcccgag acggtggttg aagtactcac cataaccagc
     1381 tttttcgatg acctcacggg cagcgcggtc cacttcatga gcagtcacac ctggcttgat
     1441 aaagtcaaga gcagcttgtt gggcttcaag agtcaagttg taaatatctt tcttgaattg
     1501 gtctggtttg ccgacagcga ctgtacgagt catatctgac gcatagccat tgaccagaac
     1561 acccaggtca aagaggagaa gagcatcatt ttcaacctta ttagctgctg gaatgccgtg
     1621 tggattcgca gcattatcac cagtcaagac catggtatca aagctcattt cataaccttc
     1681 acgtttcatg gcaaagtcga tttgtgcgat gatatctgtc tcagtcttat caagagaaat
     1741 attgtcaaaa ccaacatgaa cagccttgtc agcataaaga cctgcaacca tcattttttg
     1801 cacttcatca gctgatttga tgaggcgcat gcgttggata cgaggagtga ggttgtcaaa
     1861 ctcagcagtc tcaaaaactg ttttcaaacc atggtatttg gtcaagatga gattgtcaaa
     1921 ctcaacagcg acacgtttga agtcaagttg tggaagagca tgtttgattt tttgccatgg
     1981 attttcagaa tcgacatagc ccactactgg gaaggaaacg gtgctacttg cacgttctac
     2041 ttcaagagct gggacaaaga ggagaggttc ctgatccgct aggacaaaga ggaacatttg
     2101 gcgttcatgg ggatcactgt aaaaaccagt gaggtaattg attgtgacgg ggtcagatac
     2161 gacagcgacg tctagttttt ctgattcaag atatgttagg atttgttgta atttagacat
     2221 atgctacctt ctttctaccc ctctattttg gcaaaaaatg agagaaaatg caagggagaa
     2281 gggtaaaaga aaagacaaaa aactccgaca agataacgga gttctttgat atcattttcc
     2341 tttgtttaag aaaagtcagc cttgcttttg acgtcactgt actcttcagc gatttcttgg
     2401 ctgagaatgt cctcataggc agggagttgg atgtcctgac catatttctt cttgagggca
     2461 gtagtaacta ggcgataagc cagattggca ttacgagaga ggataggccc gtggaagtag
     2521 gaaccaaaga cattcttata atgaacccct tcaccgacct tttcttcgtt gtttccattt
     2581 ccatagacaa cctgtcccag cggtttttgg tcatcagaga ggaaggtacg accttggtga
     2641 ttttcaaatc catagtaggt ttcatcgaaa tcttcattgt gaatcttgat gtcaccgata
     2701 aaacggttat tggtctggtt gagcgtgtag tgtcccatga cccctagccc ttcgatacgt
     2761 tttcctgaag cttcaacata atattgaccc aatagttgga aaccaccgca gatagccaga
     2821 actacaccgt cgttttggat gtagttgtca atgctctctt ttttagcagg taggtcgtct
     2881 gcaatgatac tttgttcaaa gtcttgacca ccaccgaaaa aggcgatgtc gtagtgattt
     2941 tcatcaaagt catcatggag agaaacgatg tcaacggtca catgggctcc cagtttttca
     3001 gccacatact tgagcatgag gatgtttcca ttgtccccgt aggtattcat gagatttccg
     3061 tagaggtggg caatgttgag ctgatagggg taattgctat cttttgagga aagtgaagta
     3121 taaaccatta gttcatctcc tttctaacaa tctgacgact agccagcagt tcacgaaatt
     3181 ccagcatggc agtataagtt gccagaatat aggcatgctt gcagtcttga ttctcaatgg
     3241 tcttgagaac ttgctccaga ttactcgttt cagtgatttt ctcagctgga tagccagtca
     3301 ctcggaggcg acgagcgatt tcagaatgac gaacaccgcc agcgttgatt tcaggaatgt
     3361 ccatgtcagt gatttgctca aagtctgcat cccagatcca gctagtgtca attccatctg
     3421 catagttggc attaaggagg acagataggc taaatggata aggtgctagt ttgatcattt
     3481 cgatagcttg ggttgcaccg actggatttt taatcaagac aagggtacat tccttgtcac
     3541 cgatatgaaa ggtttcttgg cgtccaaaga cagcacggct cttgtcaaat ccctgtttga
     3601 tgagttggga atctgcgccg aggaaacggg cgatggccac agcagctagg gcgttataga
     3661 tattatagag cccgccgatt tggataccgt attcttggcc gtctatgaca aagcgagagc
     3721 gattgttggt caactcaacc agttttgtca aacgatagtc gagatcagga cgtttacatc
     3781 cacaaccttc acagatatag gcacccaagt ttgcataggt attatgctca tatttgagga
     3841 tgccttggca gtcaggacag agaatccctt cggtattgta gtgagccagt tgggctggtc
     3901 ctttttccaa gtcaaaacca aaatactcta tagggtttgg aatagttggc ttgtagaaaa
     3961 gtggactgtc tccgttaagg agaacagtag cagttggaac ttttcgaatg gcatccaata
     4021 tcatgttata ggtagtatag atttcaccga aacggtccat ctggtcacgg aaaatattag
     4081 taataacaaa taagcttggc tggatatagt cacagatacg agatagactg gcctcgtcga
     4141 tttctaggac ggcaatattt ttcccagttt tagaagattt ggctgttaag aaggttgtcg
     4201 caattcctgt aatcatgttg gcaccgcttg ggttggtcag aacttgacca taaacttctt
     4261 ttaaaatacc gacagtgagg gcagttgtca aggtttttcc gttggttcca gtgaccacga
     4321 caatctcgta gttcttagct aggttttgta aaatatcttt atcaaattga agggcgactt
     4381 tacctgggag cgtacttcca cggccaagac ggcttaaaat gaagtgggaa gaacgcccag
     4441 caagaaggcc caaagtagtt tttaagttca tgtttctatt atatcataaa agaggagaaa
     4501 gacagatttg agattccgca gaagtaaaaa cagcccaaag agggctgttc gatacgatta
     4561 aatctcaact taaatcgcaa acaagtcatt caagttctca gccaaggttg ggtgagtgaa
     4621 gatttgtttt gtgaagtaag tgtaaggaat cttgttgtcc atagcaacag tgatgatgtt
     4681 gatgatttct tgagaacctt ctgagaagat gcttgcacca agaatttctt ttgtttcagt
     4741 attaacaaca gctttgaaag ctccgcgaag gtctccattt acgtgaccac gaggcatggc
     4801 tgcaacaggg atttctttca ctgcgtatgg aagtttcaaa tcagctgctt ggctttcagt
     4861 caaaccaact tgtgaaagtg caggtgtgat gaacatagta tttggcacat tgagacggtc
     4921 ctcaagtgtg tagctgccat ctccagcaag gtagctgtaa acaacacgga agtcatcaag
     4981 tgaaatgtaa gtaaattgaa gaccaccgtt gacatctcca actgcaaaga caccaggaac
     5041 gtttgtttga cagtgtttat ctactttaat agcgccacgt tcagttagtt caatatctgt
     5101 attttcaagt tgaagtggtt ctacatttgg tttgcgtcca gttgcgtaga gaagggcgtc
     5161 gaaacggtaa gtttcgtctt cagttacgac aagcacttgg tcaccgtcgt ttttaatttc
     5221 agtagtatgg atattttgaa gcaattcaat accgtcttct tccatgtatt gtttagcaag
     5281 agctgcgatg gaaggttctg cacgaggtag gaatgtatcc aaggcatcta ggactgtaac
     5341 cttgcttcct agtttattgt aaaggccagc aaattcaaga ccgatatttc cgccaccaag
     5401 gactccaagt ttttcaggca atttatccaa gctttggata cctgttgagt caaagatgtt
     5461 tttgcttgta gcaagtccag gaattggcaa gacgtttgaa acagcaccag tgttgatgac
     5521 gattgtttca gcagtcagtt ctttcttttc atcaccagct tggatttcga tgactttatt
     5581 tgaaaggaag tgagcttccg catcaaagat atctacgcct gtaccagcaa cagtcgcata
     5641 gtttttaccg ttgaggcgac cagtgatcgt gtttttagta gcaatcactt cttcaaaaga
     5701 caagtccttt tcagcagcaa ctagcaaggt tttagttggg atacaaccaa tgttgataca
     5761 agttccaccg tacatagcct tgctgcgttc aacgagggca acttttttgc cagctgaagc
     5821 caatttacct gctagtgttt taccagcttt accaaatcca ataacaatta aatcgtatgt
     5881 taacatttat cttcctccta ttcgaatttc attctagcac aagaaaaaaa cttttgcaca
     5941 attctgctac ggaaaagaca gaaaaagata aaaacgcttt ccagacaaaa aactagtaat
     6001 tttttgacaa gcttgataaa ctaaaatcct atctattttt atataagaaa gaataaatgt
     6061 tcgaaaatag gaggttttat gaaatcgaat cgttatatta ttgcctttgc tggggtcatt
     6121 ttacacttaa tgctgggttc gacttatgct tggagtgttt atcgtaaccc tattattgaa
     6181 aaaacgggat gggatcaggc ttctgttgcc ttcgccttta gtctagcaat cttttgtttg
     6241 ggcttatcgg ctgcatttat ggggcgtttg gtagaaaaat ttggtccgaa agtcatgggg
     6301 agtctatctg cttttctata cgcaggtgga aatatcttaa caggatttgc aatagaccgt
     6361 caggaactgt ggttgttgta tctagcttat ggcattttag gtgggcttgg tttgggagca
     6421 ggctatatta cccctgtgtc aacgattata aaatggtttc ctgataaacg tggtctcgca
     6481 acaggtttag cgattatggg gtttggtttt gcttctttat tgactagtcc catagcgcaa
     6541 cacctcatcg caggggtagg gattgtagaa actttttata ttttaggagc aagttacttt
     6601 attatcatgc tcctagcttc acaattcatt aagcgtccaa atgagcaaga gcttgcaatt
     6661 ttatcttctt cagggaaaga aaaaacagcc tctttgacgc aaggaatggc tgcaaatcag
     6721 gctctaaaaa gcaatcggtt ttatatgctt tggattattt tctttatcaa catagcttgt
     6781 ggtttaggct taatttcagc ggcatcgcca atggcacagg agatggctgg cttgtctaca
     6841 agtcatgcag cagtaatggt gggtgttttg gggattttca atggatttgg tcgcttgctc
     6901 tgggcgagtt tgtctgacta tatcggtcgc cctctaacc
//
LOCUS       DAVHSO010000085         6337 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.086, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000085 DAVHSO010000000
VERSION     DAVHSO010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6337)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6337)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6337
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.086"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..306
                     /locus_tag="VVR18_002051"
                     /pseudo
     CDS             1..306
                     /locus_tag="VVR18_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            473..673
                     /locus_tag="VVR18_002052"
     CDS             473..673
                     /locus_tag="VVR18_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000226586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033508.1"
                     /translation="MVVSASASSTSTQAQEQVDKSELRALSQELDQRLKALATVSDPK
                     IDATKAVLLDAQKAPEDSALTE"
     gene            698..1114
                     /locus_tag="VVR18_002053"
     CDS             698..1114
                     /locus_tag="VVR18_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033509.1"
                     /translation="MKTALDSLKDVIANASDSKPTQDKKDAKQGTEDSKDSDKMTETN
                     SVPAGVIVVSLLALLGVIAFWLIRRKKESEIQQLSTELIKVLGQLDAEKADKKVLAKA
                     QNLLQETLDFVKEENGSAETETKLVEELKAILDKLK"
     gene            1345..2052
                     /gene="ccdA2"
                     /locus_tag="VVR18_002054"
     CDS             1345..2052
                     /gene="ccdA2"
                     /locus_tag="VVR18_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004237834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEU6033510.1"
                     /translation="METIVFLISVFLAGVLSFFSPCIFPLLPVYAGILLDDQESAKSF
                     SLFGRKVLWSGLIRTLCFIAGISLIFFILGFGAGYFGHILYANWFRYGMGAIIIILGL
                     HQMEIFHLKKLEVQKSFTFKKSDSNRYWSAFLLGITFSFGWTPCIGPVLSSVLALAAS
                     GGNGAWQGAIYTLIYTLGMALPFLVLALASGLVMPYFSKIKRHMMLLKKIGGFLIVLM
                     GILLLLGQVNVLAGIFE"
     gene            2063..2620
                     /gene="sdbB"
                     /locus_tag="VVR18_002055"
     CDS             2063..2620
                     /gene="sdbB"
                     /locus_tag="VVR18_002055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     lipoprotein SdbB"
                     /protein_id="HEU6033511.1"
                     /translation="MKKVMFAGLSLLSLVVLMACGEEETKKTQAAQQPKQQTTVQQIA
                     VGKDAPDFTLQSMDGKEVKLSDFKGKKVYLKFWASWCGPCKKSMPELMELAAKPDRDF
                     EILTVIAPGIQGEKTVEQFPQWFQEQGYKDIPVLYDTKATTFQAYQIRSIPTEYLIDS
                     QGKIGKIQFGAISNADAEAAFKEMN"
     gene            2994..4385
                     /locus_tag="VVR18_002056"
     CDS             2994..4385
                     /locus_tag="VVR18_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HEU6033512.1"
                     /translation="MNIFRTKNVSLDKTEMHRHLKLWDLILLGIGAMVGTGVFTITGT
                     AAATLAGPALVISIVISALCVGLSALFFAEFASRVPATGGAYSYLYAILGEFPAWLAG
                     WLTMMEFMTAISGVASGWAAYFKGLLSQYGIALPQALNGTFNPQAGTFVDLLPILVLV
                     LVTSLVLLNAKAALRFNSILVILKFSALALFVLVGIWNIKFDNWSNFAPYGFGQIYGA
                     STGIMAGASLMFFGFLGFESISMAVDEVKTPQKNIPRGIVLSLSIVTILYALVTLVLT
                     GVVHYSHLNVDDAVAFALRSVGISWAANYVSLVAILTLITVCISMTYALSRMIYSLAR
                     DGLVPAAFKELTKTSKVPKNATILTGLASAVAAGMFPLASIAAFLNICTLAYLILLAY
                     GLIRLRKEKGMPKAGEFKTPLVPLLPILSIIICLSFMLQYNVNTWIAFLVALLVGSII
                     YFTYGYKHSTIEE"
     gene            4528..5445
                     /gene="adcAII"
                     /locus_tag="VVR18_002057"
     CDS             4528..5445
                     /gene="adcAII"
                     /locus_tag="VVR18_002057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding lipoprotein AdcAII"
                     /protein_id="HEU6033513.1"
                     /translation="MKKQNLFLVLLSVFLLCLGACGQKESQTGKGMKIVTSFYPIYAM
                     VKEVSGDLNDVRMIQSSSGIHSFEPSANDIAAIYDADVFVYHSHTLESWAGSLDPNLK
                     KSKVKVLEASEGMTLERVPGLEDVEAGDGVDEKTLYDPHTWLDPEKAGEEAQIIADKL
                     SEVDSEHKETYQKNAQAFIKKAQELTKKFQPKFEKATQKTFVTQHTAFSYLAKRFGLN
                     QLGIAGISPEQEPSPRQLTEIQEFVKTYKVKTIFTESNASSKVAETLVKSTGVGLKTL
                     NPLEADPQNDKTYLENLEENMSVLAEELK"
     gene            5453..>6337
                     /gene="phtD"
                     /locus_tag="VVR18_002058"
     CDS             5453..>6337
                     /gene="phtD"
                     /locus_tag="VVR18_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtD"
                     /protein_id="HEU6033514.1"
                     /translation="MKINKKYLAGSVAVLALSVCSYELGRHQAGQVKKESNRVSYIDG
                     DQAGQKAENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISE
                     ELLMKDPNYQLKDSDIVNEIKGGYVIKVDGKYYVYLKDAAHADNIRTKEEIKRQKQER
                     SHNHNSRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNEL
                     SASELAAAEAYWNGKQGSRPSSSSSYNANTAQPRLSENHNLTVTPTYHQNQGENISSL
                     LRELYAKPLSERHVESDGL"
BASE COUNT         1944 a         1128 c         1345 g         1920 t
ORIGIN      
        1 ccagaaaaag tagccttatt tcttaagaat tttaatagtt taaagcacct agcacctgtt
       61 tagattgatg aaacaggatt tgatacttat ttttatcgag aatatggtcg ctcattaaaa
      121 ggtcagttaa gaagaggcaa agtatctgga agaagatatc agaggatttc tttggttgca
      181 ggtctaacaa atggtgaatt aatcgctcca atgacttacg aagagacgat gacgagcgac
      241 ttttttgaag tatggtttca gaaatttctc ttaccaacat taaccacacc atcggttatt
      301 atagtaaaat ggaataagaa caggacaaat cgatcaggac aatcaaatca atttctagca
      361 atgttttaga agtccatatg tactattcta gtttcaatat accataactg ctcctagtca
      421 acctgcaagt cctgtcccag ctccaagctc agctccgact caagatccta gagtggtagt
      481 aagcgcttcg gctagctcaa cgagcacaca agctcaagag caagttgaca agtctgaact
      541 tcgtgccttg agtcaagagt tagaccaacg cttgaaagct ttggcaacag tatctgatcc
      601 gaaaatcgat gcaaccaagg ctgtcctcct agatgctcaa aaagctccgg aagatagtgc
      661 cttgacagag taaggtctgc atactgcagt agagtctgtg aagactgcct tggactctct
      721 caaagatgtg atagcaaatg ctagcgacag caagcctaca caggacaaga aggatgcaaa
      781 acaaggaacg gaagatagta aggattcaga taagatgact gaaacaaact cagttccagc
      841 aggagtgatt gtggtcagtc tacttgccct cctaggcgtg attgccttct ggctgattcg
      901 ccgtaagaaa gagtcagaaa tccagcaatt aagcacggaa ttaatcaagg ttctaggaca
      961 gctagatgca gaaaaagcgg ataaaaaagt ccttgccaaa gcccaaaacc ttctccaaga
     1021 aacccttgat ttcgtgaaag aagaaaatgg ctcagcagag acagaaacta aactagtaga
     1081 ggagcttaaa gcaatccttg acaaactcaa gtaaaacatg atttatgaaa tgtcagactt
     1141 aaaagacatt ttcgttcaca aaagcagcga cgagtaatcc ttgtcgttgc tttttggcta
     1201 ttttggggga taagatccgc cttgactagc aaaagaaaag attggtccaa tagtgcccga
     1261 tacgattttg cgtagcagaa agcttacaaa taaaattgaa tatagtaaaa taggattaga
     1321 attattaaga aagttggttc tttattggaa acgatagtat ttttaatctc tgtttttcta
     1381 gcaggtgttt tatccttttt ttctccttgt atttttcctc ttctgccagt ctatgctggg
     1441 attttattgg atgatcaaga aagtgcaaaa agcttttctt tgtttgggag aaaggttctc
     1501 tggtcaggct tgattcgaac actttgcttt atcgctggta tctctctcat tttctttatt
     1561 ctaggctttg gtgctggtta ctttggtcat attctctatg caaattggtt tcgatatggc
     1621 atgggagcta ttattatcat tttgggtctt caccagatgg aaatttttca tttgaagaaa
     1681 ttagaagttc aaaaaagttt tacctttaaa aaatcagatt ctaatcgtta ttggtcagct
     1741 tttttacttg gtattacctt tagctttggt tggacacctt gtattggtcc agttttaagt
     1801 tctgttttag cacttgcggc ttctggaggc aatggcgctt ggcaaggagc gatttatact
     1861 ctcatttaca ctctgggcat ggcccttcct ttcttggtat tggcactagc ttcaggtcta
     1921 gtcatgccat attttagtaa aatcaagcgt catatgatgc tactaaagaa aattggtggt
     1981 ttcctcattg ttttaatggg aattttgtta ctattaggac aagtaaatgt tctagctgga
     2041 atttttgaat aaaggaggac aaatgaaaaa agtaatgttt gctggcttaa gtctcttgtc
     2101 attagttgta ttgatggcct gtggtgagga agaaactaaa aagactcaag cagcacaaca
     2161 gccaaaacaa caaacgactg tacaacaaat tgctgttgga aaagatgctc cagactttac
     2221 attgcaatcc atggatggca aagaagttaa gttatctgat tttaagggta aaaaggttta
     2281 cttgaagttt tgggcttcat ggtgtggtcc atgcaagaaa agtatgccag agttgatgga
     2341 actagcggcg aaaccagatc gtgatttcga aattcttact gtcattgcac caggaattca
     2401 aggtgaaaaa actgttgagc aattcccaca atggttccag gaacaaggat ataaggatat
     2461 cccagttctt tatgatacca aagcaaccac cttccaagct tatcaaattc gaagcattcc
     2521 tacagaatat ttaattgata gccaaggaaa gattggaaag attcaatttg gtgctatcag
     2581 taatgcggat gcagaagcag catttaaaga aatgaactag aatcgataaa atctgattac
     2641 aagatgtagt cagattttgg taacttctaa aactaacttc cagtttccca caacctagct
     2701 tttagtatga gaaaaacgcg tgacatcagt ggaaatccgt cttagattaa cttccactgg
     2761 ttttcttttt cttgatatat aagggttcaa aagcgaaaag actcagaaaa agtgcacgac
     2821 aaatagccct aaaacagagt cgtctgagac taacttccag ttttgggaga gagatggaag
     2881 ttactttgag aagttacggt agtcagattt ttttagaaaa atattttata aatattcaca
     2941 tatctcctat atttatggta aaatagaatc atcagtttat tttggagtca aagatgaata
     3001 tatttagaac aaagaatgtt agtttagata aaacagagat gcataggcat ttgaagttat
     3061 gggatttgat tttgctgggt attggagcca tggtagggac aggtgttttt acaatcacag
     3121 gtactgcagc tgctacactt gctggtccag cactagtgat ttcaatcgtt atttctgcct
     3181 tgtgtgtggg attatcagcc ctcttttttg cagaatttgc ctcgcgagta cccgctacag
     3241 gaggtgccta tagttacctc tatgctatct taggagaatt ccctgcctgg ttggctggtt
     3301 ggttaaccat gatggagttc atgacagcca tatcaggcgt agcttcgggt tgggcagctt
     3361 attttaaagg cttgctctct caatacggga tagcccttcc tcaggcttta aatggtacct
     3421 ttaatcctca agcagggaca tttgttgatt tattgcctat tcttgtcttg gtcttggtga
     3481 cttcgcttgt tttactaaat gccaaggcag ccttacgctt taattcgatt ctagttattt
     3541 tgaaattttc cgctttagct ctctttgttt tagtaggaat ttggaatatt aagtttgata
     3601 attggagcaa ttttgctcct tacggttttg gacaaatcta tggagctagt actggtatta
     3661 tggctggtgc gtccttgatg ttcttcggtt ttttgggatt tgaatccatc tctatggctg
     3721 tagatgaagt caagactcct caaaaaaata ttcctagagg gattgtctta tcgctttcta
     3781 tcgtaaccat tctctatgcc ttggtgaccc ttgttttgac tggtgtggtt cactatagtc
     3841 atttaaatgt cgatgatgcc gttgcctttg cccttcgtag tgttgggatt agttgggcag
     3901 ccaactatgt gtcattagtg gctatcttga ccttgattac agtttgtatt tcgatgacct
     3961 atgccctatc gcgtatgatt tacagtttag cacgtgacgg cttagtgcct gctgccttta
     4021 aggaactgac gaagactagc aaggtaccaa agaatgctac tatcttgaca ggtctagctt
     4081 cagcagtagc agcaggaatg ttcccactag ccagtattgc agccttttta aatatttgta
     4141 ccttagccta cttgatcctg ctggcttatg gtctgattcg cttacggaaa gaaaaaggaa
     4201 tgcccaaagc tggggaattt aaaacaccat tggtacctct gttaccaatt ttatcgatca
     4261 tcatttgttt atccttcatg ttacagtata atgtgaacac ctggattgct ttcctagttg
     4321 cgttgttagt aggaagtatt atttacttca cttatggcta taagcattct accatagaag
     4381 aataaagtga aagtctattg agttgttgac actcagcaga tttttatatg tgaaagaaat
     4441 ttcaaatttt ttctaaaaat atcttgacag attaaatttt caggagtaga atatttacta
     4501 gttaattaaa tggttaagga gttgttcatg aagaaacaaa atttattttt agtcctgtta
     4561 agtgtctttc ttttatgctt gggggcttgt ggtcaaaagg aaagtcagac aggaaagggg
     4621 atgaaaattg tgaccagttt ttatcctatc tatgctatgg ttaaggaagt atctggtgac
     4681 ttgaatgatg ttcggatgat tcagtcaagt agtgggattc actcttttga accttcggca
     4741 aatgacatcg cggccatcta tgatgcagat gtctttgttt accattctca tacgctagaa
     4801 tcttgggcag gaagtttaga tcccaatcta aaaaaatcca aagtgaaggt cttagaggct
     4861 tctgagggaa tgaccttgga acgtgtccct ggactagagg atgtggaagc aggggatgga
     4921 gttgatgaaa aaacgctcta tgaccctcac acatggctag atcctgaaaa agctggagaa
     4981 gaagcccaaa ttatcgctga taaactttca gaggtggata gtgagcataa agagacttat
     5041 caaaaaaatg cgcaagcctt tatcaaaaaa gctcaggaat tgactaagaa attccaacca
     5101 aaatttgaaa aagcgactca gaaaacattt gtaacacaac atacagcctt ttcttatcta
     5161 gcgaagagat ttgggcttaa tcaacttggt attgcaggca tctctcctga acaagaacca
     5221 agtccacgac aattaacaga aattcaggaa tttgttaaaa cctataaggt taaaacgatt
     5281 tttacagaaa gtaatgcttc ttcaaaagta gctgaaactc ttgtcaaatc aacaggtgtg
     5341 ggtcttaaaa ctctgaatcc tttagaggca gacccacaaa atgacaagac ctatttagaa
     5401 aatctggaag aaaatatgag tgttctagca gaagaattaa agtgaggaaa gaatgaaaat
     5461 caataaaaaa tatctagcag gttcagtggc agtccttgcc ctaagtgttt gttcctatga
     5521 acttggtcgt caccaagctg gtcaggttaa gaaagagtct aatcgagttt cttatataga
     5581 tggtgatcag gctggtcaaa aggcagaaaa tttgacacca gatgaagtca gtaagagaga
     5641 ggggatcaac gccgaacaaa ttgttatcaa gattacggat caaggttatg tgacctctca
     5701 tggagaccat tatcattact ataatggcaa ggttccttat gatgccatca tcagtgaaga
     5761 acttctcatg aaagatccga attatcagtt gaaggattca gacattgtca atgaaatcaa
     5821 gggtggctat gtgattaagg tagacggaaa atactatgtt taccttaaag atgcggccca
     5881 tgcggacaat attcggacaa aagaagagat taaacgtcag aagcaggaac gcagtcataa
     5941 tcataactca agagcagata atgctgttgc tgcagccaga gcccaaggac gttatacaac
     6001 ggatgatggg tatatcttca atgcatctga tatcattgag gacacgggtg atgcttatat
     6061 cgttcctcac ggcgaccatt accattacat tcctaagaat gagttatcag ctagcgagtt
     6121 agctgctgca gaagcctatt ggaatgggaa gcagggatct cgtccttctt caagttctag
     6181 ttataatgca aatacagctc aaccaagatt gtcagagaac cacaatctga ctgtcactcc
     6241 aacttatcat caaaatcaag gggaaaacat ttcaagcctt ttacgtgaat tgtatgctaa
     6301 acccttatca gaacgccatg tggaatctga tggcctt
//
LOCUS       DAVHSO010000086         6177 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.087, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000086 DAVHSO010000000
VERSION     DAVHSO010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6177)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6177)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6177
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.087"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1747..3138
                     /locus_tag="VVR18_002059"
                     /pseudo
     CDS             1747..3138
                     /locus_tag="VVR18_002059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838376.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tail fiber domain-containing protein"
     gene            3119..3322
                     /locus_tag="VVR18_002060"
     CDS             3119..3322
                     /locus_tag="VVR18_002060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001091107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033515.1"
                     /translation="MNTEQLNQALQMTIREMSTTSTDSMITSNILSIQLNEQREENQR
                     LQARVDELEALLDEQTKPADKGE"
     gene            3325..3675
                     /locus_tag="VVR18_002061"
     CDS             3325..3675
                     /locus_tag="VVR18_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033516.1"
                     /translation="MAETIQNTDNLLDLTKITEPFDLASALRYMKENGEFIRCKNVSD
                     DFYMYRDVQKRPVIVNGRRQFKDVETVWAFNQWGGTIATINVAVLLNHEFYIMKFDAE
                     GNPDWTVPTVEPKE"
     gene            3684..4100
                     /locus_tag="VVR18_002062"
     CDS             3684..4100
                     /locus_tag="VVR18_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003038967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HEU6033517.1"
                     /translation="MQIEFFNFLRSVVQTEDGLVLYALALIVSMEIIDFVTGTIAAII
                     NPDIEYKSKIGINGLFRKISGVLLLMILIPASVLLPEKTGFAFLYSIYLGYIAFTFQS
                     LIENYRKLKGNVTLFQPIVKVFQRLLEKDDDTKKGE"
     gene            4104..4436
                     /locus_tag="VVR18_002063"
     CDS             4104..4436
                     /locus_tag="VVR18_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001186229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HEU6033518.1"
                     /translation="MQQITEIIIAFATSFLTVAVGGIVKAVKDYLLRKGGEKAVIIAE
                     ILAKNAVHAVEQVASETGYKGEEKLEQARAKVRAELTKYNISMTDKDLDTFVESAVKQ
                     MNDAWKGR"
     gene            4440..5396
                     /gene="lytA"
                     /locus_tag="VVR18_002064"
     CDS             4440..5396
                     /gene="lytA"
                     /locus_tag="VVR18_002064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HEU6033519.1"
                     /translation="MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHWR
                     KDPELGFFSHVVGNGRIMQVGPVNNGSWDVGGGWNTESYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
                     REQFKQDIENGLSAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSD
                     RWKKHTDGNWYYFDQSGEMATGWKKIAEKWYYFDVEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK"
     gene            complement(5534..5713)
                     /locus_tag="VVR18_002065"
     CDS             complement(5534..5713)
                     /locus_tag="VVR18_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033520.1"
                     /translation="MRKVIQELLDSSMSTSAISQGAGVPWTTVSDLRKGKTSMDKMAL
                     LTAEKLYEFATTDKQ"
     gene            complement(5855..6004)
                     /locus_tag="VVR18_002066"
     CDS             complement(5855..6004)
                     /locus_tag="VVR18_002066"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033521.1"
                     /translation="MNKEDWLRLLEKAIDNIPETVTAIASLVTAITVARQNKKRKPKS
                     RQRKR"
BASE COUNT         1983 a         1148 c         1393 g         1653 t
ORIGIN      
        1 ggctctatcc atcaggaaat cctgaacgca accaaggata aggcagataa gactctagtt
       61 gtatctgaag ccgggaaatt gcgtgaagaa ttttcaaaaa tgaaggtggg aggccggaat
      121 ctatggataa aatccaagac ggttggagct gtaattgaaa aattacctga aaaccacgtc
      181 acaggtcaaa aagaatgcta taggctagag aacaactcta ctttaacgtt caaccttgaa
      241 ccagatttca gctcaaggtt gtatcaaaaa gttactttta gcgcttggat caagtacgaa
      301 aatgtagtcc aaggtcgaaa tttttggaat gtatttaatt gcttcaaaca ttatcttttt
      361 agaaaaaata gtgagaccgg agtacagagt ggtccagatt atgctacgct tggtatgtat
      421 aaaggttcgg cagattggaa atatattaca ttcacttatg actactctga aaaaacaaat
      481 tttgatcaat tgaagacatc attgcgattc aatcttgaag gtgctacaag cggtacagct
      541 tgggtaacag gaatcaaggt tgaaatcggt agtgtggcga cggactggag tcctgcgcct
      601 gaggacgctg atggtctcat cactgaagct aaggctacct ttgagcggac agctcagggc
      661 ttgcgaaccg acttatcagc tattcaggaa tatgtaaata aagacggtca gcgacaggaa
      721 gccctacagc gctatactcg tgaggagagc gcgagacaag cgacagcagt ccgtgagctg
      781 gtcaatcgtg atttcgttgg taaggctact tatcaagaag atgttaaggg tatcaatcag
      841 aggattgaag ctgttaaaac tagtgcgaat aaagacatcg ctagtcaaat cgctagctat
      901 cgtcaatctg tagatggtaa gttcacggat atttcaagtc agataactac ttataagcaa
      961 gatgtgggcg gtcaaatcag tggtctatca aatagactta caagcagtga gcaaggaacc
     1021 actactcaga tttcaaatat ttcaaatcgg ataaacagta ataaacaagg cacagataat
     1081 cagatttcaa atttaaagac tcaggtcgct acaaacaagg ataatgctga acgacaaatg
     1141 ggtagaatat ctgatcaggt ttctgcaaac aaagcgaatg ctgatagtca atttgcgaat
     1201 gtgaccaatc aactagcacg aaaagtagag actactgact tccagcgtgt taaggaaacc
     1261 agtaaacttt acgagcggat tttgggcaat actgaaaatg gaattgcgga taaggttgct
     1321 cgcatggctc tgaccaatca actgtttcag gttgaggttg ggaaatatag tgtaagcggc
     1381 cctaacctca ttaagaatag tgattttaaa aatgctacga atgaatgggg ctcaactcaa
     1441 aatttaggaa gattggttaa gcatagcttt tatcacaacg ggcagaaaga ccttatgcgt
     1501 ttaagtaatg caactaaaaa cgaaaacttt ttgtatagtc accgttttaa tcttgaacga
     1561 aatactgact atgtactgaa ttttagagga tttaacaaca gtgctctcgc aagctatgat
     1621 gtttatattt tgggacgaag agcaggcgag agcgatggat tcacaatcgt taagaaagtt
     1681 gttagcagca agaaactatc tacctctaga tgcgaagatg tctcagtaac ttttaattcc
     1741 ggagaaatgg ataatgctta cattcgtttt gataacaatg gctcatcatc aggaacagct
     1801 gatttgtata ttacagaagt tgacttgtac aaaggttata aacctagaac atggcaacca
     1861 catccagaag atgcagtcgc agatgcgaat aagaagcttg aagccacgca aacaaaaatg
     1921 actctactaa ctggctcatg ggcagttcaa aacatcaact cggctggaga tatcatctct
     1981 ggaatcaatc ttggcgccaa tggacataac cgcttcgttg ggaaattgac ccacatcact
     2041 ggagagaccc tgattgacag agcagtcatc aagtctgcca tggttgataa gctcaaaacg
     2101 gccaattttg aagctggttc ggtcacgact acgatattag acgctgaagc ggtcacggct
     2161 gataaagtga gatttgatgc tgcgtttatt aggaaaatga ctgcaagtga cgcttttatt
     2221 gaccaactga catctaaacg tatcttctct actaaggttg agtccgtcat ttctagttca
     2281 accttcctag aagcctatca aggtcgaatc ggtggattca ctattgggcg ttttgctcaa
     2341 ggaagaggtc gctggatttc tggtatcaac caattctcag ttggcatggg gaatggtgaa
     2401 ggaggaagct ataatggcga aaataccgca ttttgggcga actggggtca cagttggaac
     2461 tctcctggcc ccaatgcttg gtatgtaaca acatcaggaa atatgtattg ccgaaacgga
     2521 gcagatttcc acgggaaggt tgacttttcg aattcatcga gagcaaactt ttatgggaat
     2581 actacttttt ctcgttctcc tgtgttttca aatggtatcg aacttggaag taaagatgtg
     2641 cttggtgatg gctggaatcc caaaggagga aggaatgcgg ttgtttggtg gaatcaggtc
     2701 ggtagcggta gcgtgaagta ttggatggaa caaaaatcag acagacgctt aaaagagaac
     2761 atcacagata cagctgtgaa agccttggac aaaatcaaca gattaagaat ggttgcattt
     2821 gatttcatcg aaaataagaa acatgaggag attggtctaa tagctcaaga ggctgaaacc
     2881 atcgttccaa gaattgtctc acgagatcct gagaatccag atggctatct gcatattgac
     2941 tataccgctt tagttcctta cttaatcaag gctattcaag aattaaatca aaaaatagaa
     3001 aaaatggaga aaacaatagc atgaataaca acatgttgac caatatcaca ctttaaagca
     3061 attcaggagc ttgctcttga aaatagaaaa cgaacacaca gattggagaa cttagaaaat
     3121 gaacacagaa cagcttaacc aagccttaca aatgacaatt cgtgaaatgt caacaacttc
     3181 aacagattcg atgattacaa gtaatatctt gagtattcag ttgaatgagc aaagggaaga
     3241 gaatcaaaga cttcaagcac gagtggatga gctggaagct ctgcttgatg aacaaactaa
     3301 accagcagac aaaggagaat agacatggca gaaacaattc aaaacacaga taacttacta
     3361 gaccttacaa aaatcacaga accatttgat cttgcgagtg ctttgcgcta catgaaagaa
     3421 aatggagagt tcattcgttg caagaatgta agcgatgact tctatatgta tcgtgatgtt
     3481 caaaaacgtc ctgtgatcgt aaatggccgt cgccaattca aggatgttga aaccgtttgg
     3541 gcgttcaacc agtggggtgg tacaatcgca acaatcaacg tagccgttct gttgaatcat
     3601 gaattctata tcatgaaatt tgatgcagag ggcaatcctg actggacggt tccaacggta
     3661 gaacctaaag aataggaggt tgtatgcaaa ttgaattttt caattttcta agaagtgtcg
     3721 tacagactga agatggtttg gtattgtacg ctctagcact gattgtctca atggaaatca
     3781 ttgattttgt gacagggacg attgcggcaa ttatcaatcc tgacatcgag tacaagagca
     3841 aaatcggcat caatgggcta tttcgtaaga tttcaggggt tctcttactg atgatcctca
     3901 ttccggcgtc cgttttgttg cctgaaaaga caggttttgc attcttgtac tcaatctatc
     3961 tcgggtacat cgcatttact tttcaatctc tcattgaaaa ttaccgcaaa ttaaaaggaa
     4021 atgttactct ttttcagccg attgtaaaag tatttcagcg attacttgaa aaagatgatg
     4081 acacgaaaaa aggagaataa caaatgcaac aaattactga aatcatcatt gcttttgcga
     4141 caagcttttt aacagtagca gtaggcggta ttgtaaaagc agtaaaagat tatcttttgc
     4201 gtaaaggcgg agagaaagcg gtgatcatcg ctgaaattct agctaaaaat gcagttcatg
     4261 ccgttgagca agtagcttca gagactggct ataagggcga agaaaagctg gagcaggctc
     4321 gtgctaaagt ccgtgctgag cttacaaaat acaatattag catgactgac aaagacttag
     4381 acaccttcgt agagtcagca gtgaagcaga tgaatgacgc atggaaagga cgatagggaa
     4441 tggatatcga tagaaacaga ctacgtacag gcttgcccca ggttggggtg cagccttatc
     4501 gacaagtaca tgctcactca acaggtaacc gcaactcaac cgtacagaat gaagcggatt
     4561 atcactggcg gaaagaccca gaattaggtt ttttctcgca cgttgttggg aacggtcgca
     4621 tcatgcaggt aggacctgtg aacaacggaa gttgggatgt tgggggcggt tggaatactg
     4681 agagttacgc agcggttgaa ctgattgaaa gccattcaac taaagaagag ttcatgacgg
     4741 actaccgcct ctatatcgaa ttgctacgca atctagcgga cgaagcaggc ttgccgaaga
     4801 ctcttgatac agacgacttg gcaggtatca agacgcatga atactgtacc aataaccaac
     4861 caaacaacca ctcagaccat gtggatccat atccatatct tgctaaatgg ggcattagcc
     4921 gtgaacagtt taagcaagac atcgaaaacg gcttgagcgc tgcaacaggc tggcagaaaa
     4981 atggcactgg ctactggtac gtacactcag acggctctta tccaaaagat aagtttgaga
     5041 aaatcaacgg tacctggtat tatttcgatg gctcaggcta tatgctttca gaccgctgga
     5101 agaagcacac agacggtaat tggtactact ttgaccaatc aggcgaaatg gctacaggct
     5161 ggaagaaaat cgctgagaag tggtactatt ttgatgtaga aggtgccatg aagacaggct
     5221 gggtcaagta caaggacact tggtactact tagacgctaa agaaggcgcc atggtatcaa
     5281 atgcctttat ccagtcagcg gacggaacag gctggtacta cctcaaacca gacggaacac
     5341 tggcagacaa gccagagttc acagtagagc cagatggctt gattacagtt aaataaatag
     5401 aaaggaaact ttctaaattg ttctttcacc gcaggcttag gcttgcggtt ttttatttgc
     5461 tctgattctt taaaaaagcg ttttcttgaa gaatagagag gtgttttgtc aaaaataaaa
     5521 acagtgaccg aaatcactgc ttatcagttg tagcaaattc ataaagtttt tctgctgtga
     5581 gaagtgccat tttgtccatg cttgtttttc cttttctgag gtcagaaaca gtagtccatg
     5641 gaactccagc accttgggaa atagcagatg tagacatcga actgtctaac aattcttgaa
     5701 taacttttct catcttattt gtccttttta ttttttagat aaatatatac attgattgca
     5761 attataaaaa tagctattgc actaaccatt gcatttcctc tttccatttg ataaaataga
     5821 ggtgtaaggg gctttcgccc caacctctta gcgtttacct ttttctttga cgggatttcg
     5881 gtttacgctt tttgttttgc cttgcgaccg ttattgcggt cactagactt gcgatagcag
     5941 ttaccgtttc aggaatattg tctattgcct tttcaagtaa cctgagccaa tcttctttgt
     6001 tcaacttcat cacccccttt ccttatcttg attatattat atcacggtac accgagaaag
     6061 tcaagcgttt tgatgaagtt tttttaattt tttcaaaaaa aaatagacct tgtccagagg
     6121 tcggggagtt ggagggggca ccctccaaaa gcattgattt aataaggttt tatttta
//
LOCUS       DAVHSO010000087         6101 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.088, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000087 DAVHSO010000000
VERSION     DAVHSO010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6101)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6101)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6101
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.088"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            33..863
                     /locus_tag="VVR18_002067"
     CDS             33..863
                     /locus_tag="VVR18_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001114300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEU6033522.1"
                     /translation="MSEKQKISVLMSVYIKENPTFLKDAIESVQNQTLKPSELVLVED
                     GPLTPELYQVLDQVETESEIPVKRYPLEQNQGLGLALRQGVLQCQYNIIARMDTDDIA
                     VPDRFEKQLQLMEKDKLDLLGGHIAEFIDNPDEIVSYRRVPTQHADIVAYQRMRSAFN
                     HMTVMFKKDMVLKAGNYEDGLYMEDDLLWLNMIAAGAKTGNLDQILCQVRVGAGMFER
                     RGGLRYLKLYRQARQRMLKRGQISYMEYAKSVAIQMIVALCPGFVRQFIFMKLLRKSK
                     "
     gene            949..2799
                     /locus_tag="VVR18_002068"
     CDS             949..2799
                     /locus_tag="VVR18_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEU6033523.1"
                     /translation="MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILF
                     YGLINPAPVDYIIYTSLTFLFYQLMIGFWGLNASISRYSKITDFMKIFFGATASSILS
                     YSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
                     GDGGALFMDSYQHPTSELELVGILDKDAKKKGQRLGGIPVLGSYDNLSELAKRHQIER
                     VIVAIPSLDPLEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGR
                     QEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVY
                     HELIREIQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFK
                     NNIRGTYNVAKAVDEAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTY
                     CAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAK
                     DGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVD
                     NQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE"
     gene            complement(2976..3053)
                     /locus_tag="VVR18_002069"
                     /pseudo
     CDS             complement(2976..3053)
                     /locus_tag="VVR18_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(3103..3735)
                     /locus_tag="VVR18_002070"
     CDS             complement(3103..3735)
                     /locus_tag="VVR18_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase-like protein"
                     /protein_id="HEU6033524.1"
                     /translation="MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIR
                     GFMGPPLESSFATCLSKDQISEAMQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPL
                     YITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIII
                     RDIKFDMLGARETGIQKLPVTWGFGEQADLLNYQPDYIAHKPLEVLAYFQ"
     gene            complement(3757..4629)
                     /gene="sdaAA"
                     /locus_tag="VVR18_002071"
     CDS             complement(3757..4629)
                     /gene="sdaAA"
                     /locus_tag="VVR18_002071"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="HEU6033525.1"
                     /translation="MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLME
                     RNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNE
                     HNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASI
                     SGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEV
                     PCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLAT
                     TPTGRRLQKEIFGE"
     gene            complement(4638..5309)
                     /gene="sdaAB"
                     /locus_tag="VVR18_002072"
     CDS             complement(4638..5309)
                     /gene="sdaAB"
                     /locus_tag="VVR18_002072"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="HEU6033526.1"
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPT
                     EVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKE
                     SNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDI
                     PGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHN
                     VNFFK"
     gene            5551..>6101
                     /locus_tag="VVR18_002073"
     CDS             5551..>6101
                     /locus_tag="VVR18_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEU6033527.1"
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLS
                     EIAETHNTTVEKLAENNHIDNIHLIYVDQELVIDGPVAPVATPAPATYAAPAAQDETV
                     SAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNG
                     DYSAENQERVADAYVAGRYGSWTA"
BASE COUNT         1741 a         1197 c         1372 g         1791 t
ORIGIN      
        1 gtggaaggaa atctatacat tggagaaaaa ctgtgtctga aaagcaaaaa atcagcgtat
       61 tgatgtcggt ctatatcaag gaaaatccga catttttaaa ggatgctatt gagagtgttc
      121 aaaatcagac tctgaaaccg agcgaattgg ttctggttga ggatgggcct ttgacacctg
      181 agctctatca ggtgttagac caggtggaga ctgagtctga aattccagtg aaacgctatc
      241 ctcttgagca gaatcaaggt ttgggtctgg ctcttcgaca gggtgttttg cagtgtcagt
      301 acaatatcat cgctcgtatg gatacggatg atatagctgt tccagaccgt tttgagaaac
      361 agcttcagtt aatggagaag gacaagcttg acctattagg tggacatatt gcagaattta
      421 ttgataatcc tgatgagatt gtttcttacc gtcgtgttcc gactcaacat gcagatattg
      481 tagcttatca aaggatgaga agtgccttta accacatgac tgtcatgttc aagaaggaca
      541 tggttctcaa ggcaggcaac tatgaggatg gcctttatat ggaagatgac ctcctctggc
      601 tcaatatgat tgctgcagga gccaagactg gaaatctgga tcaaatcttg tgtcaggttc
      661 gtgtcggagc agggatgttt gagcgtcgtg ggggactgcg ttacctcaaa ctctatcgtc
      721 aggctcgtca gcgcatgctg aagagagggc aaatttctta catggagtat gccaagagtg
      781 ttgccattca gatgattgtt gccctttgtc caggatttgt cagacagttt atttttatga
      841 aactgttacg aaaaagcaag taaaagattg tagcaaatcg taaactggat aaaaagtgtt
      901 ataataacaa tataactatc cagttctttt aaggaggagt aaatttctat gaataaaaaa
      961 ctcacagatt atgtgattga tctggtggaa attttaaata aacaacaaaa gcaggttttc
     1021 tggggaatat ttgatatttt cagtatggtg gtttccatca ttgtatctta tattttattt
     1081 tatgggctga ttaatccagc acctgttgac tacattatct atacgagttt gaccttcctg
     1141 ttctatcaat tgatgattgg tttttggggc ttgaacgcga gtattagtcg ttacagcaag
     1201 attacggatt tcatgaaaat cttttttggt gcgactgcca gcagtatcct gtcatatagt
     1261 atctgctatg ccttcttgcc actcttctcc atccgtttca tcattctctt tatcttgttg
     1321 agtaccttct tgattttatt gccacggatt acttggcagt taatctactc cagacgcaaa
     1381 aaaggtagtg gtgatggaga acaccgtcgt accttcttga ttggtgctgg tgatggtggg
     1441 gctctcttta tggatagcta ccaacatcca actagtgaat tggaacttgt tggtattttg
     1501 gataaggatg ctaagaaaaa gggtcaaaga cttggtggta tccctgtttt aggctcttat
     1561 gacaatctgt ctgaattagc caaacgccat caaatcgagc gtgtcatcgt tgcgattccg
     1621 tcgctggatc cgttagaata tgagcgtatc ttgcagatgt gtaataagct gggtgtcaaa
     1681 tgttacaaga tgcctaaggt tgaaactgtt gttcagggcc ttcaccaagc aggtactggc
     1741 ttccaaaaaa ttgatattac ggaccttttg ggtcgtcagg aaatccgtct tgacgaatcg
     1801 cgtctgggtg cagaactgac aggtaagacc atcttagtca caggagctgg aggttcaatc
     1861 ggttctgaaa tctgtcgtca agttagtcgc ttcaatcctg aacgcattgt cttgctcggt
     1921 catggggaaa actcaatcta ccttgtttat catgaattaa ttcgtgagat ccaagggatt
     1981 gattatgtac ctgtgattgc ggacattcaa gactatgatc gtttgttgca agtctttgag
     2041 cagtacaaac ctgctattgt ttatcatgcg gcagcccaca agcatgttcc tatgatggag
     2101 cgcaatccaa aagaagcctt caaaaacaat atccgtggaa cttacaatgt tgctaaggct
     2161 gttgatgaag ctaaagtgtc taagatggtt atgatttcga cagataaggc agttaatcca
     2221 ccaaatgtta tgggagcaac caagcgcgtg gcggagttga ttgtcactgg ctttaaccaa
     2281 cgtagccaat caacctactg tgcagttcgt tttgggaatg ttcttggtag ccgtggtagt
     2341 gtcattccag tctttgaacg tcagattgct gaaggtgggc ctgtaacggt gacagacttc
     2401 cgcatgaccc gttactttat gaccattcca gaagctagcc gtctggttat ccatgctggt
     2461 gcttatgcca aagatgggga agtctttatc cttgatatgg gcaaaccagt caagatttat
     2521 gacttggcca agaagatggt gcttctaagt ggccacactg aaagtgaaat tccaatcgtt
     2581 gaagttggaa tccgcccagg tgaaaaactc tacgaagaac tcttggtatc aaccgaactc
     2641 gttgacaatc aagttatgga taagattttc gttggtaagg ttaatgtcat gcctttagaa
     2701 tccatcaatc aaaagattgg agagttccgc actctcagtg gagatgaatt gaagcaagct
     2761 attatcgcct ttgctaatca aacaacccac attgaataaa aaagaaaaac gcatattatc
     2821 aagttaacaa ccttggtaat atgcgtttta ttatgtagag acttatactc tttgaaaatc
     2881 tcttcaaacc acgtcaacgt cgccttgccg taggtatggt tactgacttc gtcagttcta
     2941 gccacaacct caaaacagtg ttttgatctg acttcgtcag ttctatctgc aacctcaaaa
     3001 cagtgttttg agcagcccgc agctagtttc ctagtttgct ctttgatttt cattgagtat
     3061 tacttcattt tcttctgaaa tggaattgtt acccagtcta tgctattgaa aatacgccaa
     3121 aacttctaag ggtttgtgag cgatataatc aggttgatag tttagtagat ctgcttgctc
     3181 tccaaatccc caagtgacgg gcaatttctg aatacctgtt tctcgagctc ccagcatatc
     3241 aaacttgata tctctgatga tgatggcttg ttctggtgct agttgatgtg tctgcagggc
     3301 ttggtgaatg acatctgcct tatggggtgc ttcagggcta gaaccataaa tgccatcaaa
     3361 gaaatgatgg atttccaagt tttttgccat gtcttgagca gtagatgtat tctttgtcgt
     3421 ggtgatgtag agtggataac tgcttgataa ctcctcaagc aagtctataa tctgaggaaa
     3481 gagttgagct tcatagatgc cttttgcctt atagtaagaa cgatatatct gcatggcttc
     3541 agaaatttgg tctttggaca ggcaggtcgc aaaactactt tcgagaggtg gtcccataaa
     3601 accacgaata gttttggcat cagggctagg cacccccagc tctttaaagg tataggtaaa
     3661 ggcattgtga atcccgatag aactatcaac gagggttcca tccaaatcga aaaaaatcgc
     3721 tgtgatagag gtcatggttt ctcctatttg ataagcttat tctccgaaaa tttctttttg
     3781 gaggcgacga ccagtagggg tggtagcgag tccaccttca gctgtttcac gaaaggcagt
     3841 tggcatgctt gctcctactt ggtacatggc atcgatcact tcatccacag ggattttaga
     3901 ttcgatacct gccaaggcca tgtctgctgc gatgaaagca aagctagctc ccatggcatt
     3961 acgtttgaca cagggaactt cgaccaaacc tgcaacaggg tcacagatga ggcctagcat
     4021 atttttaatg acaaaggcaa tagcttgact ggcctgataa ggtgttccac ctgcagccag
     4081 agtcaaggcg gcagcactca tagcagaggc tgaaccaact tcagcttgac acccaccctc
     4141 agcacctgag atggaggcat tgtttgcgat gactagtcca aaggcaccag cagcaaagag
     4201 gaaatccaat tgttgctcgt ggctgaggtc taatttttca atagcagcag tgagaacgga
     4261 tggcagacag ccagcacttc cagcggttgg agtggcacag accaagccca ttttggcatt
     4321 gtgttcattg actgcgatgg catttcgggc agccgagaga atcgtataat ctgacagagt
     4381 ttttccgttt tcgatgtagt gatccaattt ggcagcatct ccacctgtca ggccactacg
     4441 agatttattt tcattgaggc caagttggac agaggctttc ataacttcca gattgcgttc
     4501 catgagaagg aagacttctt cacgttcgcg accggtcaat tcaaactctg ttgtaatcat
     4561 gagttctgcg acatttcctt gaaagtccag atctgcttgc tcgaccaatt ctttgataga
     4621 ataaaacatg cttcctccta tttaaagaaa ttgacattgt ggagatgagg gatttttcgg
     4681 atttcttcga tagcctcatc acagttgcga ctgtcaactt cgataatcat aatggctttt
     4741 tcaccagctt tttcacgagt gacattcatc tgggcgatat tgataccata gcgggaaagc
     4801 gcctctgtaa caagggcaat catacctgga atatcttgat gaacgatgat gatagtcggt
     4861 gtattcatat tgagagagac ggcaaaacca ttgagttcgg ttacctgaat atttcctcca
     4921 ccgatagaaa taccagtcac gctgatggtc ttgtgggcat ttttaacagt aattttagtg
     4981 gtgttagggt gaggggcatt gctttctttc tgaatggtcc agacaatctt gataccacgc
     5041 ttgtgggcaa tttccagact atttggaatt tcaggatcat ctgtatccat tcctaaaata
     5101 cctgcaacaa gggctaggtc tgttccgtga ccacgatagg tcttggcaaa tgagttaaaa
     5161 agttggaatt caacttctgt cggagtatca tcaaaaatgg aagagacaat cttcccaata
     5221 cgaacagcac cagcggtatg gctactagat gggccaatca taactggtcc gatgatatca
     5281 aagacagatt gaaaacgaag tgatttcatc agtttcccct tataaaaatt cttatctcta
     5341 ttatatcaaa gaatgagggg cttggcttta attgtggatg aaaacctttc taatacctca
     5401 aatagcataa aaatagtatc ttttatgaca aaaaacacct tatttaggga aataaaaaat
     5461 aattttgtaa tatttctaca taaaagtgtc aagaaacggt aatatttaaa gggtatgata
     5521 gaactataga aagaaggaga attttcgaat atgaaatcaa taactaaaaa gattaaagca
     5581 actcttgcag gagttgctgc cttgtttgca gtatttgctc catcatttgt atctgctcaa
     5641 gaatcatcaa cttacactgt taaagaaggt gatacacttt cagaaatcgc tgaaactcac
     5701 aacacaacag ttgaaaaatt ggcagaaaac aaccacattg ataacattca tttgatttat
     5761 gttgatcaag agttggttat cgatggccct gtagcgcctg ttgcaacacc agcgccagct
     5821 acttatgcgg caccagccgc tcaagatgaa actgtttcag ctccagtagc agaaactcca
     5881 gtagtaagtg aaacagttgt ttcaactgta agcggatctg aagcagaagc caaagaatgg
     5941 atcgctcaaa aagaatcagg tggtagctat acagctacaa atggacgtta tatcggacgt
     6001 taccaattaa cagattcata cctgaacggt gactactcag ctgaaaacca agaacgtgta
     6061 gcagatgcct acgttgcagg acgttacggt tcatggactg c
//
LOCUS       DAVHSO010000088         5693 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.089, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000088 DAVHSO010000000
VERSION     DAVHSO010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5693)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5693)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5693
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.089"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            210..524
                     /locus_tag="VVR18_002074"
     CDS             210..524
                     /locus_tag="VVR18_002074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033528.1"
                     /translation="MWVLGFILFLIFFYSNDSKKIKKLEKKIKRLERKEKGNAEMSRL
                     LQEMIGKEPIITGVYIGPDNWEVVDVDEEWVKLRRVDNTGKEKFKLQRIEDIQTVEFD
                     GE"
     gene            534..740
                     /locus_tag="VVR18_002075"
     CDS             534..740
                     /locus_tag="VVR18_002075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033529.1"
                     /translation="MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSI
                     IIALKISQIFNETVESVFRLEEDE"
     gene            740..937
                     /locus_tag="VVR18_002076"
     CDS             740..937
                     /locus_tag="VVR18_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033530.1"
                     /translation="MNKYKVIYYVVVIALLVSVFLLIGMDLSWFNPYQSDQFVWVYFA
                     LIPVIEWIEKKSKNLASEKGE"
     gene            940..1674
                     /locus_tag="VVR18_002077"
     CDS             940..1674
                     /locus_tag="VVR18_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3169 family protein"
                     /protein_id="HEU6033531.1"
                     /translation="MKKKRRLLFLMSIVLGGFLGMFVGMFKARVESHEIILDVKALMP
                     WISAICLLIGFISMFLTFNFLKKSRKFHSLYQEEMDDDLNETYYVQMYRNLEFGTIAF
                     NITGVAIPLAIFISLSEVIILHTNPQTFFLSFLLFVVFLVAQKSLFKTIAIVRQFDLE
                     FFATPKDVLNYINSYDEGERQANLEQSFRILFQLHQYVLPALYIFLIILSFLTGEIQL
                     LAFLLVGAIHVYINVMQLPMVKRYFK"
     gene            1686..2327
                     /locus_tag="VVR18_002078"
     CDS             1686..2327
                     /locus_tag="VVR18_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6033532.1"
                     /translation="MKLLKNLGWILLALLSFLFIYGFIQGLATASLALGASPYAVTLL
                     YVVLAGVYVYGIYKWYQKAPVYIEKSGFNRFIWLPVLVWFLSLVVQFFLPDDPSVNQQ
                     IATDLTLSQPLFSFFAVVIFAPLTEEIVFRGMLARYLFPKQDNSKRTLIFLLVSSLLF
                     ALIHFPGDVQQFFVYFSLGFSLGLAYISRKGLVYSISLHALNNLVGFLMILML"
     gene            2345..2575
                     /locus_tag="VVR18_002079"
     CDS             2345..2575
                     /locus_tag="VVR18_002079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000832182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033533.1"
                     /translation="MKRVILVAVIQAVVLFFIIGALAYAFKGDFFYNYLAVVFAPIAG
                     VLRFGTAYITEIVLPRKAAEIAEKRKAGKKSK"
     gene            2611..2691
                     /locus_tag="VVR18_002080"
                     /pseudo
     CDS             2611..2691
                     /locus_tag="VVR18_002080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            2927..4690
                     /gene="aspS"
                     /locus_tag="VVR18_002081"
     CDS             2927..4690
                     /gene="aspS"
                     /locus_tag="VVR18_002081"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HEU6033534.1"
                     /translation="MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREG
                     IMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIV
                     LNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEF
                     IDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKC
                     FRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITEGLIARVMKETKGIEVTLPFPRVKY
                     DDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEAPAVKAIVVKGAADNYSRKDI
                     DKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADT
                     LEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQ
                     EETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSAEEANDQ
                     FGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTV
                     ALKQLEELSLQVEEDETNKTN"
     gene            4668..5609
                     /locus_tag="VVR18_002082"
     CDS             4668..5609
                     /locus_tag="VVR18_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEU6033535.1"
                     /translation="MKQTKRIKRWRYYLRRFAYQIKILRVLQSISREKYDEKISASLV
                     YGFLSAVAVNFFFQPGHVYSSGATGLAQIISALSNHWFGFHIPISLSFYAINFPLMVL
                     AWYQIGHKFTVFTFITVSMSSLFIQFVPVATLTEDPIINSLFGGVVMGLGIGFALRNN
                     ISSGGTDIVSLTIRKKTGKNVGSISFLVNGTIMLIAGLTFGWKYALYSMITIFVSSRV
                     TDAVFTKQKRMQAMIVTNHPEKVIEKIHKKLHRGATMIHDAEGTYNHERKAVLITVIT
                     RAEFNEFKQIMTQVDPSSFVSVSENVHILGRFVEIDN"
BASE COUNT         1618 a         1040 c         1263 g         1772 t
ORIGIN      
        1 aaccatacct acggcaaggt gaagctgacg tggtttgaag agattttaga agagtattaa
       61 tgatagataa agtggtcagg aacttactcc tgaccttttt cttttgcaaa atgacaaaaa
      121 tcataaactt tttgacaaat atacttatca aaaagaaaaa gatgtgttac aatgtaagca
      181 agttaagaga aaagaagaaa ggagctatga tgtgggtact aggatttata ctatttctga
      241 ttttctttta ttctaatgat tctaaaaaaa tcaagaaact agagaagaaa atcaaaagac
      301 ttgagcgaaa agagaaagga aacgcagaaa tgtcgagatt attacaagaa atgattggaa
      361 aggaaccaat tataacggga gtgtatattg gcccagataa ctgggaagtt gtggatgttg
      421 atgaggaatg ggtaaagcta cgacgtgtag ataatacggg aaaagaaaaa ttcaagttgc
      481 aacgtattga agatatccaa accgttgaat ttgacggaga gtaggtgtgt aacatgcaac
      541 taaaaaatcg tctaaaagag cttcgagctc gtgatggtct caatcaaacc gacctagcca
      601 aactggcagg ggtttccaga cagaccatta gcctactaga acgggatgag tacaccccat
      661 ccattatcat tgccctgaaa atatctcaaa ttttcaacga aacagtcgaa tcggtatttc
      721 gtttggagga ggacgagtga tgaacaagta taaagtgatt tattatgtag tggtcatagc
      781 tttattagtc agtgtatttc tactgattgg gatggactta agctggttta atccctatca
      841 aagcgaccaa tttgtttggg tctactttgc tctcatccca gtaattgaat ggattgaaaa
      901 gaaatccaaa aatctagcaa gtgaaaaagg agaatgaata tgaaaaagaa acgtagattg
      961 ttatttttga tgtctattgt cttggggggg ttcttgggca tgtttgtagg gatgtttaag
     1021 gcacgtgtcg aatcccacga aattatttta gatgtaaaag ccttgatgcc atggatatca
     1081 gctatttgtt tactgatagg tttcattagt atgtttttga ctttcaattt cttaaagaaa
     1141 agtagaaaat ttcattcctt gtatcaagag gaaatggatg acgatctgaa tgaaacctat
     1201 tatgtgcaaa tgtatcggaa tcttgagttt ggaaccattg cttttaatat tacaggtgta
     1261 gcgattccat tggctatttt tatttcatta agtgaggtga ttatattgca tacaaaccct
     1321 caaacatttt tcctttcttt cttactcttt gtggtattct tagtcgctca aaaatctctt
     1381 tttaaaacca ttgcgattgt tcgtcagttt gatttggaat ttttcgctac accaaaggat
     1441 gtcttgaact atataaattc ttatgatgaa ggggagcgtc aggctaattt ggaacagagt
     1501 tttcgaattt tattccaatt acaccaatat gtcttaccag ccttatatat ttttcttatt
     1561 atcctttctt tcttgacagg agagattcag ttactagctt tcttgcttgt aggagccatc
     1621 catgtttata tcaatgtgat gcagttacct atggtaaaac gttatttcaa ataaaggagt
     1681 tatctatgaa attacttaaa aaccttggct ggattcttct agcccttcta tcctttttat
     1741 ttatctatgg ctttattcag gggctcgcga ctgcgtcgct tgctttaggc gcttcaccct
     1801 atgctgttac tctactctat gtggtcttgg ctggagtata tgtgtacggc atttacaaat
     1861 ggtatcagaa agctcctgtt tatattgaga agagcggctt taaccgattt atttggcttc
     1921 ctgtcttggt ttggttctta tctctggtcg ttcaattctt cttgccagat gatccttcag
     1981 taaatcaaca aatagcgaca gacttgacct tgtctcaacc acttttctca ttctttgctg
     2041 tggttatttt tgctcctttg acggaagaga ttgtttttag agggatgtta gcacgctatc
     2101 tctttcctaa gcaggacaat agtaaacgaa ccctgatttt tcttctggta tctagtcttc
     2161 tatttgcctt gattcatttt ccaggtgatg tgcaacaatt ttttgtctat tttagccttg
     2221 gttttagttt gggtttggct tacattagca gaaaaggtct ggtctacagt atttctcttc
     2281 acgctttgaa taatttagtc ggctttttga tgattctcat gctataatag agtcaggagg
     2341 tcacatgaaa cgagtaattt tagtagcagt gattcaggca gtcgttctat ttttcatcat
     2401 tggagcgcta gcttatgcct tcaaaggcga tttcttctat aactatctag cagttgtctt
     2461 tgctcctatt gcaggtgtac tgcgttttgg gacggcttac ataacggaaa ttgtcttgcc
     2521 tcgaaaggca gccgaaatcg ctgaaaagcg taaagcaggc aaaaaatcaa aataaaagag
     2581 tccggtgaag ttcatcggat ttttgtatta tactcaatga aaatcaaaga gtaaactagg
     2641 aagctagccg caggttgctc aaaacactgt tttgaggttg tggatgaaac tgacgaagtc
     2701 agctcaaaac atggttttga ggttgtagat gaaactgacg aagtcagtaa ccatacctac
     2761 ggtaaggcga cgctgacgtg gtttgaagag attttcgaag agtattagcg ctaattttta
     2821 gggctttcac ctgactttta aagactggca aacttttctg atgattttca tgaagagcct
     2881 gcgcttttat ggtaaaatag taacagaata aaagaggaga gaaataatga aacgtagtat
     2941 gtatgctggt cgtgttcgtg aggaacacat cggacaagaa ataaccttga aaggatgggt
     3001 tggccgtcgt cgtgaccttg gtggtttgat ctttatcgat cttcgtgacc gtgaaggaat
     3061 catgcagttg gttatcaacc ctgaaaaagt atctgcagag gttatggcaa cagctgaaag
     3121 ccttcgtagc gaatttgtta ttgaggtgac tggtcaggtc gctgcgcgtg agcaagccaa
     3181 tgataagttg ccaactggtg cggttgagtt aaacgtgaca gctcttattg tgcttaacac
     3241 agctaagaca acaccatttg agattaagga tggcattgag gcaaatgacg atacacgttt
     3301 gcgttaccgt taccttgacc ttcgtcgtcc agaaatgttg gaaaatctta aacttcgtgc
     3361 caaggtgacc cactctatcc gcaactactt ggatgagttg gagtttatcg acgtggagac
     3421 accattcctt tctaagtcaa cgcctgaagg ggcgcgtgat tatttagtgc cgtctcgtgt
     3481 taataagggg catttttacg ctcttcctca aagtccacaa atcacgaaac agctcttgat
     3541 gaatgctggt tttgaccgtt actaccaaat cgttaaatgt ttccgtgacg aagacttgcg
     3601 tggagaccgc cagcctgaat ttactcaggt cgacttggaa acgtccttcc ttactgagca
     3661 agaaatccaa gatattacag aaggcttgat cgcgcgcgtg atgaaggaaa caaaaggcat
     3721 cgaagtaacg ctaccgttcc ctcgtgtgaa atacgatgat gctatggctc tttacggttc
     3781 tgacaagcca gatactcgtt ttgacatgtt gcttcaggac ttgacagaag tggtcaaagg
     3841 tgtagacttt aaagtctttt cagaagcacc tgctgtaaaa gcgattgtgg tcaaaggagc
     3901 tgcggacaac tattcacgta aagacatcga caagatgacg gaagtagcca aacagtatgg
     3961 tgccaaaggt cttgcttggg ttaaggtggt tgatggagaa ttaaacggac cagttgccaa
     4021 gttcttgact ggtatccaag aagaattgac aacagcgctt gctcttgaag ataaggactt
     4081 ggttctcttt gtggcggata cgcttgaagt ggctaatgca acactgggtg cccttcgtgg
     4141 acgtattgct aaagagcttg gcttgattga taatgataag ttcaacttcc tttgggtggt
     4201 tgactggccg atgtttgaat ggtctgaaga agaaggccgc tacatgagcg cccaccatcc
     4261 tttcaccctt ccacaggaag agactgctca cgaattagaa ggtgatttgg ctaaggttcg
     4321 tgccattgct tacgatatcg tcttgaacgg ttatgagctt ggtggtggta gccttcgtat
     4381 caaccaaaaa gaccttcaag aacgcatgtt caaggctctt ggtttctcag ctgaagaagc
     4441 caatgaccag tttggtttcc ttcttgaagc catggactat ggtttcccac cacacggtgg
     4501 tttggctatc gggcttgacc gttttgtcat gttgcttgct ggagaagaaa atatccgtga
     4561 agtcattgcc tttcctaaga acaacaaggc aactgaccca atgacacaag ctccatcaac
     4621 agtcgctctc aaacaactag aggaactcag cttacaagta gaagaagatg aaacaaacaa
     4681 aacgaattaa gcggtggcgc tattatctgc gccgctttgc ttatcagata aaaattttac
     4741 gtgtcttaca aagtatctct cgagaaaagt atgatgagaa gatttcggcc tctctggtct
     4801 atggtttttt atcagcagta gcagttaatt tctttttcca accagggcat gtgtattcga
     4861 gtggtgcaac aggtctggca cagattatct ctgccttgag taatcactgg tttggttttc
     4921 atattccgat ttcgctaagc ttctacgcca ttaacttccc tttgatggtc ttagcttggt
     4981 atcagattgg ccataagttc accgtcttta cctttatcac ggtatctatg agttccttat
     5041 ttatccagtt tgtccctgtg gcaaccttga cggaggatcc cattatcaat tccctttttg
     5101 ggggtgttgt tatgggtttg gggattggtt ttgctcttcg aaacaatatc tccagtggtg
     5161 ggacggatat cgtcagcctg actattcgca agaaaacggg taagaatgtc ggtagtattt
     5221 ctttcttggt aaatggaact atcatgctga tagcaggttt gacctttggt tggaaatacg
     5281 ctctttattc tatgattacc atctttgtct ctagccgtgt gacagacgca gtctttacta
     5341 agcaaaagcg tatgcaggcc atgattgtga caaatcatcc agagaaggta attgaaaaaa
     5401 tccataaaaa attgcaccgc ggagcaacca tgatccacga tgcagaagga acctataatc
     5461 acgagagaaa ggcagtttta atcactgtca ttacacgtgc agagtttaat gaatttaaac
     5521 agattatgac acaagtggat ccaagctcct ttgtctctgt ctcggaaaat gttcatattc
     5581 taggaagatt tgttgagata gataattagt gattaatact cttcgaaaat ctcttcaaac
     5641 cacgtcagcg tcgccttacc gtatatatgt tactgacttc gtcagttcta tct
//
LOCUS       DAVHSO010000089         5556 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.090, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000089 DAVHSO010000000
VERSION     DAVHSO010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5556)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5556)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5556
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.090"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..464)
                     /locus_tag="VVR18_002083"
     CDS             complement(<1..464)
                     /locus_tag="VVR18_002083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033536.1"
                     /translation="MKFQTNNSLYKLMNLIIYLFLLYLFIDLLMKSGILDEQIDKLSE
                     LSNLFTIKIETILTVISVVFTFIATLIEYGFSLFLITLFFDKNKRNFGDILLSKNITL
                     SFSILLCYLFNPSDIKFAYFSVLTVLLIGITNYARFKNLRLTVVFSVPFLFNA"
     gene            complement(445..1041)
                     /locus_tag="VVR18_002084"
     CDS             complement(445..1041)
                     /locus_tag="VVR18_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000687786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6033537.1"
                     /translation="MKIENESKSYDKCILKNISLEIDKGIYRVEGENGSGKSTLLQLL
                     AGLETFDSGLKNCVSKDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINT
                     FFDNKIGDNYMTASTGTKFKLGLSLIFAKNWDYIFIDETLSTVDARSIDMIAKRLISM
                     KESSTIIYVSHNLLNQELISKSQRILIEEGRVYEISNK"
     gene            complement(1038..1520)
                     /locus_tag="VVR18_002085"
     CDS             complement(1038..1520)
                     /locus_tag="VVR18_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein M"
                     /protein_id="HEU6033538.1"
                     /translation="MRKSGFLIYYVLFCIVCFLLGLLLSFILKNETFATIPPKLELQF
                     TLTVLQANSTNFLLYLFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHAL
                     IEIPNFIWYQGMSQYLLYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEGIKL
                     "
     gene            complement(1517..2653)
                     /locus_tag="VVR18_002086"
     CDS             complement(1517..2653)
                     /locus_tag="VVR18_002086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033539.1"
                     /translation="MKILSKKECESILGYLNFIGITLLFFVIISLSIYFKSYLPFQGK
                     LFLLFLVVDYATLNRYNMKLPIQSKKINTFYIRKNYIFLYLLAIVKKYYSFQILQSFI
                     YLFILYFLDIIGYFYLSITLCLIAIQIISLILPSLFSIISKLFLFLSIGLLSIEQGQV
                     VIYVILLNYFILVMGILDNHASNFYFKSSRMSQKRFRSSLFILLRFCWLNKGLTFSFI
                     LISILLSYLFWYMMTMLSIDDTKIPILFLYTSIYITLMEAIIGNHKSSIGVDLALLQL
                     SALNHSKMNFFFKNAQLMMLTHLISFLQFSLLLCLIPVTSYSNDIKSILLNLLLIPFN
                     YFIAYVYYKKALFLIKGTVSLLRWSFLVLYCFLIIFVILVGGIR"
     gene            complement(2660..2956)
                     /locus_tag="VVR18_002087"
     CDS             complement(2660..2956)
                     /locus_tag="VVR18_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="HEU6033540.1"
                     /translation="MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTK
                     AAATVVNLISAYSTVTAVISIVGAITGVGSIGSGIAATVLYILKKKGAAKAALW"
     gene            complement(3499..4392)
                     /locus_tag="VVR18_002088"
     CDS             complement(3499..4392)
                     /locus_tag="VVR18_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033541.1"
                     /translation="MDELKREIGYKIKTIRRSCGKTQIDICGDESELTIRQLARIENG
                     QALATLPKLLLIADKLGVSLQNIVDVKVIEIPKGFLKLKDELIHSQTYADKGRIERKE
                     AILEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFS
                     VNDLLIIELYFFCCAMGLEDKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQ
                     TEDSLIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAEL
                     LDDQVLVQRILAEKQIDFPTT"
     gene            complement(5143..5373)
                     /gene="blpU"
                     /locus_tag="VVR18_002089"
     CDS             complement(5143..5373)
                     /gene="blpU"
                     /locus_tag="VVR18_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HEU6033542.1"
                     /translation="MNTKTMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQ
                     LGIKTRTWQGAATGAAGGAILGGVAYAATCWW"
BASE COUNT         2056 a          985 c          622 g         1893 t
ORIGIN      
        1 gcattaaata aaaatggtac agaaaacact actgtcaatc ttaaattttt aaatctcgca
       61 taatttgtta tcccaattag taatactgtc aatacgctga aataggcaaa ctttatatcc
      121 gatggattaa ataaataaca aagtaaaatg ctaaaactta aggttatatt tttagataaa
      181 agaatatctc caaagttcct cttattctta tcaaaaaata atgtaatcag aaagagagaa
      241 aatccatatt caataagagt tgctataaat gtgaaaacaa cagaaatcac tgtcaatatt
      301 gtttctattt taattgtaaa aagattagat agttcagata atttatcaat ttgttcatct
      361 aaaattcccg acttcatcag taaatcaata aacaaatata aaagaaaaag ataaataatc
      421 agattcatta atttgtataa actattattt gtttgaaatt tcataaaccc gtccttcctc
      481 tattaaaatc ctttgagatt tgctaatcaa ttcttgattc aataaattat gagatacata
      541 tataatagta gagctttctt tcatggaaat taagcgttta gcaatcatat caatacttct
      601 tgcatccact gttgataaag tctcatcaat aaaaatataa tcccaatttt tagcaaaaat
      661 taaggataag cctaatttga attttgttcc agtagatgct gtcatatagt tatctccgat
      721 tttattatca aaaaaagtat taatttgttc tttatcctca aatgatagat ggatttgaaa
      781 agaatcacac aacaactgca aattttcttc tatagtaaat ggaacaaccc caagctgatt
      841 ggtatcaagg tatagtacat ctttggagac acaattcttt aaaccactat caaaagtctc
      901 tagcccagct aaaagttgta gaagggtgct ctttcctgaa ccattctctc cttcaactct
      961 gtaaattccc ttatcaatct ctagtgatat atttttcaat atacatttat cataactttt
     1021 agattcattt tcaattttca taatttaatt ccctctatca acgctgctaa aattaataaa
     1081 agataagaaa tgatatacca ttttaaatta ctttttatat aaataagtat atttttaatt
     1141 cccctatcct tcaataatcg gtataaaaga tactgactca taccttgata ccaaataaaa
     1201 ttcggtattt caataagagc atgaggtaat attcctttta ttgtagctac tattccaatc
     1261 atctgaccag atatacccaa ttgtattcct aaagatagca aatcaaaaag ttgcaataag
     1321 ggcgaaatcg gaaaacagaa tagatatagc aaaaaatttg tagaatttgc ctgtaaaact
     1381 gtcaatgtaa attgtaattc cagtttcgga ggtatagtag caaaagtctc attttttaat
     1441 ataaagctta aaagtaaacc tagtaaaaaa cagactatac aaaataacac atagtaaatc
     1501 agaaaaccac tttttctcat ctaatgcccc ctactaaaat tacaaatatt atcagaaaac
     1561 aatataaaac cagaaaactc catctcaata aactaactgt acctttaatt aaaaatagag
     1621 ctttcttata atagacatag gctataaaat aattgaatgg aatcaataac aaattcaaca
     1681 aaatactttt tatatcatta ctataacttg tcaccggaat caaacataac aacaatgaaa
     1741 attgtaagaa agagattaaa tgcgtcaaca tcattagttg tgcattctta aaaaagaaat
     1801 tcattttaga atgattaaga gcagataatt gaagtaaagc tagatctacc ccaattgagg
     1861 atttatgatt ccctattatt gcctccatta atgtaatata tattgaggta taaagaaata
     1921 atattggtat ttttgtgtca tcaattgata acatcgtcat catataccaa aatagatagg
     1981 aaagaagaat actaatcaaa ataaaagaaa aagttaaccc tttatttaac caacaaaaac
     2041 gaagcaatat aaatagactg ctacgaaatc ttttttgact cattcgactg cttttaaaat
     2101 agaaattact cgcatgatta tctaatatcc ccatgactaa aataaaataa ttgagtagta
     2161 tgacataaat tacaacttgt ccttgttcta tagacaatag tcctatagat aaaaataaga
     2221 acaatttact tataattgaa aacaaactag gtagaattaa agaaataatt tgaatagcta
     2281 tcaaacaaag agtaatggat aaataaaaat atccaataat atctagaaaa tacaaaataa
     2341 ataaataaat gaatgattgt aaaatttgga aagaataata tttcttgaca atggcaagaa
     2401 gatagagaaa aatatagttt ttccttatat agaaagtatt tattttttta ctttggatag
     2461 gcagtttcat attataacga ttcaaagtag cgtaatctac taccaaaaaa agtaaaaata
     2521 atttcccttg aaaaggaaga tagcttttaa aatagattga caaacttatg ataacaaaaa
     2581 acaaaagggt tatcccaata aaattaagat aacctaaaat actttcacat tcttttttag
     2641 aaagtatttt catctagttc taccatagag ctgctttagc agcacctttc tttttcaata
     2701 tataaagaac tgttgctgca atacccgaac caatagaacc tactcctgtg attgcaccta
     2761 caattgaaat tactgctgta actgtactat aagcactaat caaattgact acagtagcag
     2821 cagcttttgt cgaaattcct aatgtcccag ccaacatagg aaaagaaaca acacctaagc
     2881 ttaaccaact aatgactgct aacattgctg aaacaataag aaatttatta tgaaattcca
     2941 ttcttttaga tttcatttta gtgtactcct tttgtatatt atgtatgttt tattgagagt
     3001 taattcgcac atgttgtatt cctaactctc ttcaaatgtt cgtctatatt ttatactact
     3061 tttattaaca tatctataat aaataaatta ctactacatt ttcctagatt atcaaattac
     3121 ttttatatca ctaagactca ataaaagata atgtctattt aacttttata cgattactac
     3181 ctccttttta gtttacactt cctacatcat aaataaacat actcaaccct cacaatctcc
     3241 aaataactct tctatatcat tgaaaattga gtttcatcct ctatactaat gtaggaaacc
     3301 tattaaaaca ttcctttaat ccaatataag aataccttgt tccattaatc tctacccgat
     3361 attatagata gaaccaaatt cctatactta aaaggacaaa taacgttcca cccataataa
     3421 acctcctttc tttttgaaaa cgttttcttt ataggtttag tatagcaaaa acatgaaaaa
     3481 aacaacatga cttagaagtc aggttgttgg gaaatctatc tgtttttctg ctaaaattct
     3541 ctgaactaat acctgatcgt ctagcaattc tgctagagaa atcgcctttt catagaaact
     3601 ttctgcctct aaaatattct tgtctacaaa taaagcatat tttgccttta gcaaaaatag
     3661 atgaggtcgg taaaaaacat gtcttgtttt agcaataatt ttctcaaatg tttgaatata
     3721 tatcagacta tcttctgtct gaatttggat aaataggctc agaagaactt tttccatttg
     3781 aactaggcta gccttatctt catattctga acatagcaat actttttgag ctaactcctc
     3841 aaaatgttct ttatcttcta atcccatagc acaacaaaag aaatacaatt caataatcaa
     3901 caaatcattt acagaaaaat atttcttttt taataactgc tggaaatatt cttccactaa
     3961 ccctaaaccg taggtcacat ctgaactacc ataaatatca aaacgagctt gtgtcacatc
     4021 cacaattaac tgctcttcct caggcaaatt ctcataatag ttttcatata tttcctcaag
     4081 tatagcttct tttcgttcga ttcttccctt atcagcgtag gtttgagaat gaatcagctc
     4141 atctttgagt tttaggaatc cttttggaat ctctataacc ttaacatcca caatattctg
     4201 taatgatact ccaagtttat ccgcaatcaa taataattta ggaagtgttg ctaaagcttg
     4261 cccattttca atacgtgcta gctgacgaat cgtcaactct gattcatcac cacaaatatc
     4321 tatctgagtt tttccacaag atcgcctaat agttttgatt ttataaccaa tttcacgttt
     4381 caactcatcc atagtaatac tccttaagtt gattacaaag atttcttttt cttcctaatt
     4441 cttttgtcaa tcatatataa aacgataagc gaaaacagcg gtagaacaat ataactcttt
     4501 tcactcatta tcagctgaaa tcccagggtt gctagtatct taaagatgaa aatattcatc
     4561 aaaaatagaa aaacaaatac taaaaaatat tttaaaacct tcttcatttc ttttcttcaa
     4621 ctttcctaat ttctacacct attttatcga aaatatatat aaaactccaa ataaacactt
     4681 cgactgcact ttttttggca aaaaatagac agaacaaaca tcctacctac taaaaatatg
     4741 atatgaaagg aaattgattt tttactgtca ccctaggcaa gcttgaaaca aataaatcat
     4801 tgatagtaac acttacgaca tcctatttat tacttcaatt tctaatgtct ctgctatttc
     4861 taagctacct ctggtatgat ctattcctag tcagaataga taacaccgtt ctaaattacg
     4921 attcatagtt actccttttt tgactcgtta ctataagact cctctttaca tgcgcaaaat
     4981 aattttgatt cagattcatc atttatagtt ttgattattt tttaacagat ttttctgttt
     5041 tcttctccga agactttaaa aatttttttc taattaaatc atccatataa ggaccaaata
     5101 taccaactac taaaccaata ataaaacttt taaaatccat aattaccacc aacatgtcgc
     5161 tgcataggcc acacctccaa gtatagctcc tcccgcagca ccagttgctg caccttgcca
     5221 tgttcttgtt ttaattccta gctgaagacc tcgtgctgct cctcctccaa cacctgcttt
     5281 ggcaaaatct ccccaattgc atccgccacc ttcaacgcaa gcaagcatct cagtatccat
     5341 aatttcaaat tgtgacatcg tttttgtatt cataacgaat acctcttttt tatttttaat
     5401 atttgtcttg ttacaaactt gacaagttta gtataacagt atctattaat ttttttcatc
     5461 caaatcttga attggcatcg aaacgtcttg aattagcttt tttgtttcaa aatcatctct
     5521 atttttaaaa aagatgtttt ctaatcactt ttttac
//
LOCUS       DAVHSO010000090         5418 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.091, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000090 DAVHSO010000000
VERSION     DAVHSO010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5418)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5418)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5418
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.091"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            62..235
                     /locus_tag="VVR18_002090"
     CDS             62..235
                     /locus_tag="VVR18_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEU6033543.1"
                     /translation="MIDDLDFDSLTITQLVIDIEEQFDIMLPPQKISMSEMETFGKIV
                     DLVHKCITSKESR"
     gene            232..1422
                     /locus_tag="VVR18_002091"
     CDS             232..1422
                     /locus_tag="VVR18_002091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000982805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033544.1"
                     /translation="MMPQITQFLNNIKNNNEYYSNIINDATVLDDIPILNKNDIRLNP
                     DSIISECYSKKDLIHETTNGTTDYHPLDLYKTPQERVDLNFSLWKERRKFISASNIKS
                     VKIAVFYYSHDSLMNHDGSLKKVSGLIQVPMNRADDNQYIADLKYLIEEEIKWLIGPV
                     SIFLKYAKICKKYCIKFNVEYCECTSEYVPEVYRKEIEDVFKCKFLMQYSCHELWGIA
                     FTNSLEMYNVLKPLDNSIVEGLLRKEFTSKKLYSPVVTSLTLKAMPFIKYLLTDLVYF
                     DNGYIIPFGFRYTDMVKLKTDTIHCSIFDNLFGTLPFKFEPLEQYQIIYDAQNSEIVV
                     NVLNLEVTQGDIVCSVLKEYIKEHYKSSIKVSLRNCSKFFRDNLTGKMRGIINKENIN
                     NEIW"
     gene            1438..2943
                     /locus_tag="VVR18_002092"
     CDS             1438..2943
                     /locus_tag="VVR18_002092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="HEU6033545.1"
                     /translation="MDNENEISKFFLSSENVKDMKTIANDILNMGLDFKLSEKVSQKK
                     MKEHDDLNFLSLEESIDNLPQLLEEFREKVIPYCTNFSSPNFMGFPDSGNSLGGLSGS
                     LLSDLLQQNLINASFCAPVATIMEINVIQWLRKVLGYSTSDVHNIMEVGGIVTYGGTG
                     SNSTAMLLARENKDGNTLELGVRNPRNYKVIVPKGIGHYSIASSLKWLGLGNNIIEVP
                     TENYRYNLKKLREALINHSNEIMAVVAYAGDSRTMTIDNLSEVADLVKTLTPNVWLHC
                     DACHGFSLAFSKKYKDRIKGIEKFDSISTDPHKVLGIPYCISVLLVKTPQSLNLIHSQ
                     SDLIMNENLALGQTTPFLGSKSWISLKLWLVAKHLGSEKIGAMVDKRIELTNYLQDLI
                     LKSSKLILLNRTDINSVMFMYIGDKHQEVSLSSVQNINNINKSIYDRLKDEGIYYLHQ
                     FPIIDNTETIYRGFELCPLRFMSGNPNLTIEELQKMVIEVENLGDRFVGES"
     gene            2947..4419
                     /locus_tag="VVR18_002093"
     CDS             2947..4419
                     /locus_tag="VVR18_002093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl--CoA ligase"
                     /protein_id="HEU6033546.1"
                     /translation="MSKELYNKFILTKEAGNIIYDGIEFGRDEIDRRILEISKILTAD
                     IVNLSQEAVAISCNKKINFFFLFLVVNCCDGVVMPVYARTPENKLQHICERYDINYMV
                     SDHEINLVGYSLIYHGSVFSEEYFIYECNKSFPKHEELKGIELLMLSSGTTGVSKAIS
                     LSLDNILSNTRSIQKYIIPTREDRCLIIKEITHSSSLISELINSLLSKNSVLLSDLIP
                     TVSSLGYLISTYGVTILYAIPDFLLFMNSIKFINNYRQLLGKLRLVQVVGAFCPPNYI
                     TDFHKNWPKIDLFNGYGLTEASPRVAVLGGEELYANPRCVGYPISGVGVHIDTSSNNT
                     QEGEICVTGPNIMVEYYLNEELTSKIKIGGMLRTGDIGYFDDKNRLYILGRKDNRYIK
                     SGKNIFPEEIESVVRKLPFISEVIVYPKIESGRLISILEYTICNDEEKDLNQEASEII
                     KLCKDNLEDYKIPDQYRKVKNIPHTSTGKVKRDRNNYYNE"
     gene            4412..>5418
                     /locus_tag="VVR18_002094"
     CDS             4412..>5418
                     /locus_tag="VVR18_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase"
                     /protein_id="HEU6033547.1"
                     /translation="MNELCKKYVYQLQNELNQYCDNLEGIHVIAYGSNGSNDLSISSD
                     FDVCLIVNDDSFVAMNQRLICDFTKLFHFQENLPIDKDIPLSNKLIYLSSEVELFLDN
                     PPFISDSKKVKIEDIKKTKNFLTSRTMKQRLLLNILTTDSTVLFGDEDYVNNLKYRAW
                     EDIEKIIERAYNIKLTTKNENEFLNLLYQNPVSKASGEYYLGYKKEKRNVVKHLERNV
                     HRLAILNEKKVEDIIDLSENVNRLLLKDYSFLFPSETIKKMISTYPEKKSCSIKEVLS
                     SKLTIASNNFLITNGSLEGMNIIIANLVQNNIGYLTPTFWGYGDSAKRYNKSVISAPL
                     S"
BASE COUNT         2023 a          656 c          964 g         1775 t
ORIGIN      
        1 tgaattatgc attaagatta atccgcattt agaagatcat tatttttatg attatgaaaa
       61 aatgattgat gatttagatt ttgattctct gacaatcacg caattagtta tagatattga
      121 agaacaattt gacataatgc ttcccccaca aaaaatttct atgtcagaaa tggaaacgtt
      181 tggaaaaatt gttgacttgg tacataaatg tatcacgagc aaggagagta gatgatgcct
      241 caaatcacac aatttttaaa taatataaaa aacaacaatg aatattattc aaacatcatt
      301 aatgatgcca cagttttaga tgatattcca attttgaata agaatgatat tagattaaac
      361 ccagattcta ttatttcaga atgttacagc aaaaaagatc ttatacatga aacaactaat
      421 ggcacgacag attatcatcc attggattta tacaagactc ctcaagaaag agttgacttg
      481 aacttttcac tttggaaaga aagaagaaaa tttattagtg cttctaatat taagtctgtt
      541 aagatagcag ttttttatta cagtcatgat tcattaatga atcatgatgg cagtctgaaa
      601 aaagtatcgg gattgattca agttccaatg aatagggctg acgataatca atatattgcg
      661 gatttaaaat atcttattga ggaagaaata aaatggctga ttggtccggt ttcgatattc
      721 ttgaaatatg caaagatttg taaaaaatat tgtattaaat ttaatgttga atattgtgaa
      781 tgtactagtg agtatgtccc tgaagtatat agaaaggaaa tagaagatgt atttaaatgt
      841 aaatttttaa tgcaatatag ctgtcatgag ttatggggaa ttgcatttac aaattcatta
      901 gaaatgtata atgtacttaa accattagat aattctatag ttgaaggtct gctgagaaaa
      961 gaatttactt ctaaaaaatt atatagtcca gttgttactt cactaactct aaaggcaatg
     1021 ccatttataa aatatttact tactgatttg gtttactttg ataatgggta tattatcccg
     1081 tttggcttta gatacacaga catggtaaaa ctaaaaacag ataccatcca ttgttcaata
     1141 tttgataatt tatttggaac attaccattt aaatttgaac ctttagaaca gtatcagatt
     1201 atctacgatg ctcaaaattc agagattgtg gttaatgttc taaatttaga agtgacacaa
     1261 ggtgatattg tttgctcggt tttaaaagaa tatatcaaag aacactacaa aagttcaata
     1321 aaagtttctc ttcgaaattg ttcaaaattt tttagagata atctgacagg aaaaatgcgt
     1381 gggataataa ataaagagaa tataaataat gaaatttggt aggaggcaaa ctcatacatg
     1441 gataatgaaa acgaaatttc aaagtttttt ctgagttcag aaaatgtaaa agatatgaaa
     1501 actatcgcaa atgacatttt aaatatgggg ttggatttta aattaagcga aaaagtttct
     1561 cagaaaaaaa tgaaagaaca cgatgattta aattttctca gcttagaaga gagtatagac
     1621 aatcttccgc aacttttgga agaattcagg gaaaaagtaa ttccttactg tacaaatttt
     1681 tcttccccta attttatggg ttttcctgac tcaggaaatt cattaggcgg tctttcaggt
     1741 agtttgctta gtgatttatt acagcaaaat ttgattaatg catctttttg cgctcccgtt
     1801 gctactatta tggaaataaa tgtaatccag tggttacgaa aagttttagg atattccact
     1861 tctgatgttc ataatattat ggaagtaggc ggcatcgtta cctatggtgg tacaggaagt
     1921 aattctacag ctatgctttt agcaagagaa aataaagatg gaaatactct tgaattaggc
     1981 gtaagaaacc ccagaaacta taaggtaatt gtgccaaaag gaattggtca ttatagtatc
     2041 gcatcaagtt taaagtggct gggattgggg aataatatta ttgaagttcc tacagaaaat
     2101 tatcgctata acttgaagaa acttagggaa gcactaatca accattctaa tgaaataatg
     2161 gcagtggttg catatgctgg agatagtaga acaatgacta ttgataatct atctgaagta
     2221 gcagatttgg taaagacact taccccaaat gtttggttac actgtgatgc ttgtcacgga
     2281 ttttcattag ctttttctaa aaagtataaa gataggataa aaggaattga aaaatttgat
     2341 agtatttcga cagatccgca taaagtttta ggaattcctt attgcataag tgttttgtta
     2401 gtgaaaacac ctcaatcgct taatctaatt cactctcaat cagatttgat tatgaatgaa
     2461 aacttggccc ttgggcaaac gactccattt ttgggaagta aaagttggat atctctaaaa
     2521 ttgtggttag tagctaaaca tttaggatca gagaaaatag gagcgatggt agacaagaga
     2581 atagagttaa cgaattattt gcaagatcta atacttaaga gttctaagtt aatattatta
     2641 aataggacag atattaattc agttatgttc atgtatatag gtgataaaca tcaagaagta
     2701 agcttatcat cagtacagaa tataaataac attaataaga gtatttatga cagactaaaa
     2761 gatgaaggaa tatactacct acatcaattt ccaataatag ataatacaga aaccatatac
     2821 agagggtttg aattatgtcc attacgattt atgtctggaa atcctaattt aacaattgaa
     2881 gaactacaaa aaatggttat agaagtagaa aatctagggg atagatttgt aggagagagt
     2941 taaaaaatga gtaaagagct ctataataaa tttattttga caaaggaagc tggaaatata
     3001 atatatgacg gcattgaatt tggcagggat gaaattgata ggagaattct cgaaatttct
     3061 aaaatactta ctgcagatat tgtcaactta tcacaagaag cagttgctat aagttgtaat
     3121 aaaaaaataa actttttctt tctttttctg gtagttaatt gttgtgatgg tgttgttatg
     3181 ccagtgtatg ctagaacgcc agaaaataaa ttacaacata tctgtgaaag gtatgacata
     3241 aactatatgg tttctgacca tgaaattaat ttggtagggt atagtttaat atatcatggg
     3301 agtgtttttt cagaagagta ttttatatac gagtgtaata aatcatttcc gaaacatgag
     3361 gagttgaagg ggattgaatt gttaatgctc tcttcaggta ctacaggagt ttcaaaagcg
     3421 attagtttat cgcttgataa tattttatct aatactagaa gcattcaaaa atatattatt
     3481 cctactagag aagataggtg tctcataata aaagaaatca cacactcgtc gtcattgata
     3541 tcagaattaa taaatagttt gttatcaaaa aattcagtgt tgttaagcga tttaattccg
     3601 accgttagtt cattagggta tttaataagt acatacggtg tgactatttt atacgctata
     3661 cctgattttc tattgtttat gaactctatt aaatttataa ataattatag acaattgtta
     3721 gggaaattaa gattagtaca ggttgtaggt gcattttgtc ctccaaatta tataacagat
     3781 tttcataaaa actggccaaa aattgattta tttaatggtt atggtttaac agaggcctct
     3841 cctagagttg ctgtattagg aggagaagaa ttatatgcaa atcctaggtg tgtaggttat
     3901 ccaatttcag gagttggtgt gcatattgat acaagtagca acaacaccca agagggagaa
     3961 atttgtgtta ctggtcctaa tattatggtt gaatattact tgaacgaaga gcttacttct
     4021 aaaataaaaa ttggaggtat gttaaggact ggagacattg gttactttga tgataaaaac
     4081 aggttatata ttttaggcag aaaagacaat aggtatataa aatcaggaaa aaatatattt
     4141 ccggaagaaa tagaatctgt agtaagaaaa ttacctttta tatccgaagt aatagtttat
     4201 cctaaaatag aatctgggag attaatatct attcttgaat atactatttg caatgatgaa
     4261 gagaaagatt tgaatcaaga agcaagtgaa ataataaaat tatgcaaaga taatctagaa
     4321 gattataaaa tccctgatca atataggaag gttaaaaata tcccgcacac ttctacaggg
     4381 aaagtaaaac gtgataggaa taattattat aatgaatgag ctatgtaaaa aatatgttta
     4441 tcaattacaa aacgaactaa atcagtattg tgataatctg gagggaatcc atgttattgc
     4501 ttacggttca aatggtagta atgatttgtc tatttcatct gattttgatg tttgtcttat
     4561 tgttaacgat gattcatttg ttgctatgaa tcagcggttg atatgtgact ttacaaagtt
     4621 atttcatttt caagaaaatt taccgataga taaggatatt cctttgagca acaaacttat
     4681 ttatctaagc agtgaggttg aattattttt ggataatccg ccgttcatat cagattctaa
     4741 gaaagttaag attgaagata ttaaaaaaac gaagaacttt ttaacttcaa gaactatgaa
     4801 acaacgtctc ttactaaata ttttgactac agattctaca gttttatttg gtgatgaaga
     4861 ttatgttaat aatctgaaat atagggcatg ggaggacatt gaaaaaataa ttgaaagagc
     4921 gtataatatt aaattaacga ccaaaaatga aaatgaattc ttaaatttac tatatcaaaa
     4981 cccagtatcg aaagcaagtg gagagtatta tttaggatat aaaaaagaaa aaaggaatgt
     5041 tgttaaacat ttagaaagga atgttcaccg attagcaatt ttgaacgaga aaaaggtgga
     5101 agatataatt gatttatctg aaaacgtcaa taggttactc ttgaaagatt actcattttt
     5161 atttccttct gaaactataa aaaaaatgat aagcacatat ccagaaaaaa aatcatgcag
     5221 cattaaagaa gttttgtctt ctaaattaac aatagccagt aacaatttct tgattacaaa
     5281 cggttcttta gagggtatga atattataat tgcgaacttg gttcaaaata atataggata
     5341 tttaacccct actttttggg gatatgggga ttctgcaaaa aggtataata aatcagtgat
     5401 ttcggcacct ttgtcaga
//
LOCUS       DAVHSO010000091         5216 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.092, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000091 DAVHSO010000000
VERSION     DAVHSO010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5216)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5216)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5216
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.092"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(34..825)
                     /locus_tag="VVR18_002095"
     CDS             complement(34..825)
                     /locus_tag="VVR18_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000625777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033548.1"
                     /translation="MISSIKSHNILSELYKIFYSRSTQIVLPIVFILQPLLSYISSKQ
                     ILTVGLNATPETNSSLAESIPPIEYIGFDAILLGLFAMIILGAIIGSMEYKNSSLRTS
                     LLLCSNKAVFFVIKFFVTSVFIFVVSCVSIYLSIASAQFGLGREGLNPLILSNNVWYF
                     ILLGSLSWSLLTVLSYSIAFYFKSSLGSLLFLLPQVYNLGSFLSDRIQLAKYLPVSLG
                     QDLIATSPLKITTPGRSVLFLSIWVLVISSFAYYKFLKKDVGNVI"
     gene            complement(815..1531)
                     /locus_tag="VVR18_002096"
     CDS             complement(815..1531)
                     /locus_tag="VVR18_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6033549.1"
                     /translation="MTNKIEIRNVTKTYKDGDILKNVSFTAEEGEVTAFLGPNGAGKS
                     STLRILLGLDRSSLGTALIGGKKYCDIERPLLTVGASFDGVGAPSDRTVFQHLKIAAA
                     SNGIGFSRISEVLSITDIEHKRYSKISNLSLGEGQRLGIATALLGNPQYLILDEPTNG
                     LDPSGIRWFRNFIREQASTGKTVLLSSHILSEVEAVTDKVVFIDKGSIIASGTLHNIM
                     NGFDNLEDVFFHLTGGDYDK"
     gene            complement(1544..3766)
                     /locus_tag="VVR18_002097"
     CDS             complement(1544..3766)
                     /locus_tag="VVR18_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="HEU6033550.1"
                     /translation="MDMQLNQESYSYVQLKYRLLAQIALLISYPLTKFSPKRIELLIN
                     KLSNSKLSATENEAILARDAICTVSHKCRNQDGCVKRSLGVIMFLLLLNKRASWCTGF
                     AMNPFRSHAWVEVNGNPIKELEEVSSYERVVKTLDDKNEERKHMISENIEKVDDTMTN
                     VKFRDLLVLIENKRKYFLIVLCLGILTSILTLLQPELLSKVISQKGVNLFNNPTIYML
                     ITITVGSTIISSLQYYFLQLMGESAVFQSRKNLIIQFLKLPIYKYNDLSAGDLISRFS
                     SDTSKLRAGIIQSTVALTSGLFLSLGAIFTLFLKDTYLAIITIISIALSFLFILLMSS
                     LIQTASYKAHQGLGKMTAYLNRLIVGIRTIRSTNETNSELSKMLSEVQEVKNLGIGVA
                     RVQSIMTPISNFSLQLCGIIILGIGGYRVSTGQMSIANLTSFMLLMYIAISPVGQIFS
                     SVTTISEALGALSRITEIIDLPKEEDNDIILNLESKSDRSKAIEFVNVTFSYDSYQFQ
                     DIQSDDNYILKDITFEINSGDYVSIVGPSGAGKSTLLYLIERFYDTTSGGIKIFGQDF
                     RTISRETLRSNISYVEQNSPLVAGTILENLKMGNSNVTYDECCDALEKVGLEHLIQRG
                     ASGIESPISEGGFNLSGGERQRLAMARAILSDAKILLLDELTSNLDSLSEKKMKEAIK
                     SMRGERTIIMVAHRLSTILDSDEIFVLEHGRIVGNGTHMELLESVPLYKELAKEQFLV
                     "
     gene            complement(3770..4021)
                     /locus_tag="VVR18_002098"
     CDS             complement(3770..4021)
                     /locus_tag="VVR18_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PqqD family protein"
                     /protein_id="HEU6033551.1"
                     /translation="MFNKESKSRLKIIKQDTGAIVFDKNQGIYFQTNDVGVKILELLS
                     KNESEEEIVSAISVAYSIEIDVAKQDVKDFIQSLKKGGL"
     gene            complement(4036..>5216)
                     /locus_tag="VVR18_002099"
     CDS             complement(4036..>5216)
                     /locus_tag="VVR18_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000247618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="asparagine synthetase"
                     /protein_id="HEU6033552.1"
                     /translation="EEFLNSINHDLNMRNEVSSDVSGGVDSATIAFTLNKLIPDFSIL
                     HAESSTTANSDTKWATFIAKSLGRELKKFDSIEITEKRFAIDEKYINDIMPSSPLLWA
                     DSEGYLKSVIGYQKGRKQPTHFLGIGGDELFTPMPSNSWNIVRQENLGGLLYALKYSL
                     IMRRPFFSCLLDLLDNRGYSETVIKNLEIVFNESSAPIKRELGWVDGLQVPDWLSEKS
                     KQESQIFLNSLLFSNSEPIISDRTAFQMIQSLIFQKSVLRQIQLTTNSIYWATPFLHK
                     KLIEICLQIPAKYKVSSKLTKPILQKALKGIVPIEVFNRGFKGDYSDALYSGYREAVR
                     KNFHNLEQFELVKMGIIDVEKLKLEMSLPAGNPSKIDYFEKLCSVERWIRQIKLYMKN
                     "
BASE COUNT         1717 a         1002 c          695 g         1802 t
ORIGIN      
        1 aaataaactt taaatactca cttctaaaag aattcatata acattaccta catctttttt
       61 caaaaatttg taatatgcaa aactactaat tactagcacc caaatactca gaaataaaac
      121 actgcgtcct ggtgttgtga tttttaaagg agatgttgca attaaatctt gacctaaaga
      181 tactggtaaa tactttgcaa gctgaattct gtcagaaaga aaactgccta aattatagac
      241 ttgtggtagt aagaataata atgatccaag tgaggattta aaataaaaag caattgaata
      301 ggataatacc gttaataacg accacgacaa tgaccccaat aatataaagt accacacatt
      361 attactcagt atcagagggt tcaatccctc tctccctaaa ccaaactgtg cacttgcaat
      421 agataaatag attgaaacac acgatacaac aaaaataaat acacttgtaa caaaaaattt
      481 tattacaaag aatactgcct tatttgaaca taatagcaaa ctggtacgta aagaactatt
      541 tttatattcc atacttccaa taattgctcc taaaataatc atagcaaaca agcccaataa
      601 tattgcatca aaaccaatat actcaattgg aggtattgat tctgctaaac tactatttgt
      661 ttcaggtgtt gcattcaatc caactgttaa aatttgttta gaactgatat aagacaataa
      721 cggctgaaga ataaaaacaa ttggtaaaac tatttgggtt gatctgctat aaaaaatttt
      781 atatagctct gataaaatat tatggctttt tatactactt atcatagtca cctcctgtta
      841 aatgaaagaa aacatcttct aaattatcaa atccgttcat tatattatga agtgtacccg
      901 aagctatgat acttcctttg tcaataaaaa caaccttatc agttaccgcc tctacttctg
      961 aaagtatatg tgaagataac aatactgtct tgccagtact tgcttgttct ctaataaaat
     1021 ttctaaacca tctaattcca ctaggatcta aaccatttgt aggttcatct aaaattaggt
     1081 actggggatt tcccaacagc gctgttgcaa tacctaacct ctgaccctct cctaatgaaa
     1141 ggttgcttat ttttgaatat cttttatgtt caatatcagt aatggataat acctctgata
     1201 ttctggaaaa acctattcca ttactagcag cagcaatttt caaatgttga aaaactgtcc
     1261 gatcactggg agcccctacg ccatcaaaag aagctcctac agttaaaaga ggacgttcaa
     1321 tgtcacaata tttcttacct cctattaaag cagtacctaa agatgatcta tccagcccca
     1381 aaagtattcg tagtgtcgaa ctttttcctg caccattcgg tcccaaaaag gccgtgactt
     1441 ccccctcttc agctgtaaag gatacgttct ttaatatatc cccatcttta taagtttttg
     1501 taacatttct tatttcaatc ttatttgtca taatacgata ctcctatact aaaaattgtt
     1561 ctttggccag ctctttatat aatggaacag attccaataa ctccatatga gtcccatttc
     1621 ctacaattct tccgtgttcc aaaacaaaga tttcatctga atctaaaatt gtagataatc
     1681 tatgagcaac cattattatg gttctctcac ctctcatact tttgattgct tccttcattt
     1741 tcttctcact cagactatcc aaattcgaag ttaactcatc cagcaagagt atctttgcat
     1801 cggaaagtat tgctcttgcc attgccaatc tctgtctttc tcctcctgat aaattgaacc
     1861 ctccttcact aattgggctt tcaatcccag atgcacctct ttgaattaaa tgctccaaac
     1921 caactttttc taaagcgtca caacattcat catatgttac attactatta cccattttta
     1981 gattttctaa gattgtacca gctactaatg gtgaattttg ttcaacatat gaaatattcg
     2041 aacgtaaagt ctcacgactt attgttcgaa aatcttgtcc aaatatcttt ataccaccac
     2101 tggtagtatc atagaatctt tcaatgaggt aaagaagtgt acttttcccc gcaccagacg
     2161 gaccgacaat actgacgtaa tctccactat ttatttcaaa agtaatgtcc tttaatatgt
     2221 aattatcatc cgattgaata tcttgaaatt ggtaagagtc atatgaaaaa gttacattca
     2281 caaattcaat tgctttgctt ctgtctgact tagattctag atttaaaatg atatcattat
     2341 cttcttcttt tggaagatca ataatttcag taattctact taaggctccc aaagcttctg
     2401 aaatagttgt gactgacgaa aatatttgtc ctactggtga aatagcgata tacattaata
     2461 gcataaaaga agttagattt gcaatagaca tttgcccagt agaaacacgg tagcctccaa
     2521 ttcccaaaat aattatccca cacaattgca agctaaaatt tgatattggt gtcattattg
     2581 attgcactct tgcaactcca attcccaagt tttttacttc ttgtacctca gataacattt
     2641 tagataattc tgaattcgtt tcatttgtcg accgaattgt tctaatccct acgattagcc
     2701 tatttaggta tgctgtcatt ttccccaaac cctgatgagc tttataactt gccgtttgaa
     2761 tcaaactact catcaataaa ataaatagga atgataaagc tatagaaata attgtaatta
     2821 ttgcaagata agtatccttt aaaaatagtg taaatatcgc acctaaactc aagaacaatc
     2881 cactcgtcag agcaacggtt gattgaatga tacctgctct tagtttactt gtatcactgc
     2941 taaagcgact aattaggtct cctgcagata gatcattata cttataaata ggaagtttca
     3001 aaaattgaat aattaaattt tttcttgatt gaaatactgc actttctccc attaattgta
     3061 aaaagtaata ttgcaaactg gaaataattg ttgaacccac ggtaatagtt ataagcatat
     3121 atatggttgg attgttgaat aaatttactc ccttttgaga gattacttta gataaaagtt
     3181 ctggttgtaa taacgttaaa atggacgtaa gtattcccaa acataaaacg attaaaaaat
     3241 attttctttt attttctatc aaaacaagta aatcacggaa ttttacgtta gtcatagtat
     3301 catctacttt ttctatattt tcagatatca tatgtttacg ctcttcattt ttatcatcta
     3361 gagttttcac gactctttca tacgatgata cttcttctaa ctctttaatc ggatttccgt
     3421 ttacttccac ccatgcatga gatctaaagg ggttcatagc aaatccagta caccaacttg
     3481 cacgtttatt taaaagaagt aaaaacatta ttactcctaa tgatcttttt acgcatccat
     3541 cttgattcct acacttatgg cttacagtac atattgcatc acgagctaat attgcttcat
     3601 tttctgtggc agatagtttc gagttactta acttattaat caaaagttca attcttttag
     3661 gcgagaactt tgtaagcgga taagaaatca gtaaagctat ttgtgctagt aatctgtatt
     3721 ttagctgaac ataggagtat gactcttgat tgagttgcat atccataatc tatagccctc
     3781 ctttttttag agattgtata aaatctttaa catcttgttt tgcaacatcg atttcaatgg
     3841 aatacgcaac agatatagcg ctaacaattt cttcttcgct ttcattttta gatagtaact
     3901 ctaaaatttt gacacctaca tcatttgttt gaaagtatat cccttgattt ttgtcgaata
     3961 caattgcacc agtatcttgc tttattattt tcagtctact tttcgattct ttattaaaca
     4021 taattgtaaa cctcactagt tcttcatata taatttgatc tgccgtatcc aacgttctac
     4081 cgaacataac ttttcaaaat aatcaatttt actcggattt cccgcgggta atgacatctc
     4141 taattttaac ttctcaacat caataatacc cattttaacc aattcaaact gttctaaatt
     4201 gtggaagttt ttacgaactg cttctctata tccactatat aaggcatctg aataatcccc
     4261 tttgaaaccc ctgttaaaaa cctcaattgg tacgattccc ttcaatgctt tttgcaatat
     4321 cggttttgtt agttttgaac taactttata ttttgctgga atttgaagac aaatttctat
     4381 taatttttta tgtaaaaatg gagttgccca ataaatggaa ttagtggtta attgaatttg
     4441 tcgcaatact gatttttgaa atattaagga ttgaatcatt tggaaggctg tcctatcaga
     4501 tattattggc tcagaattgg aaaataataa cgagtttaaa aaaatttgcg attcttgttt
     4561 ggatttttca ctgagccaat ctggtacttg taaaccatcc acccatccca gttctctctt
     4621 gataggtgca gaagattcgt tgaaaacaat ttctaaattt ttgatcacag tttccgaata
     4681 tcctctatta tctaacaaat ccaataggca actaaaaaat ggtcttctca ttattaaact
     4741 atatttcaga gcataaagta gtccacctaa attttcctga cgaacaatat tccaggaatt
     4801 agacggcatc ggtgtaaata attcatcacc accaatacct agaaagtgag tcggttgttt
     4861 tctacctttc tggtaaccaa tcactgattt caaatatcct tctgaatccg cccacaataa
     4921 cggagaactt ggcataatat cattgatata tttttcatct atcgcaaatc ttttttctgt
     4981 tatttctatt gagtcaaact ttttcaactc cctaccaaga cttttagcaa taaatgtcgc
     5041 ccatttagta tcactattag cagtggtact tgattcagca tgcaaaatag agaagtcagg
     5101 tatcagttta ttcaatgtaa aagcaatagt tgcagaatca acacctcctg atacatcact
     5161 cgacacttca tttctcatat tcaaatcatg attaatgcta tttaaaaact cctctt
//
LOCUS       DAVHSO010000092         5210 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.093, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000092 DAVHSO010000000
VERSION     DAVHSO010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5210)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5210)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5210
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.093"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(356..1084)
                     /locus_tag="VVR18_002100"
     CDS             complement(356..1084)
                     /locus_tag="VVR18_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU6033553.1"
                     /translation="MSTKYLFIYNEIREKILCNKYTMNEQLPDEMTLAKQFACSRMTI
                     KKALDLLVSEGLIFRKRGQGTFVLSRGSSKRKLIVPERDIRGLTKISEDAHSTIDSRI
                     IHFKLEFANEFLAEKLQVALQSPVYNIYRLRIIDGKPYVLEQTYMSTDVIPGITEDIL
                     QKSIYNYIEGKLGLHIASATKILRASSSSENEQHYLQLLPTEPVFEVEQVAYLDNGTP
                     FEYSISRHRYDLFEFNSFALRHSS"
     gene            1242..2651
                     /locus_tag="VVR18_002101"
     CDS             1242..2651
                     /locus_tag="VVR18_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEU6033554.1"
                     /translation="MKKKLVFPNLFWWGAASSGPQTEGQYGKVHENAMDYWFKTHPED
                     FFDNVGPLVASNFFHTYTEDFHLMKEIGVNSFRTSIQWSRLIKNLETGEPDPKGIAFY
                     NAIIEEAKKNQMDLVMNLHHFDLPVELLQKYGGWESKHVVELFVKFAKTAFTCFGDKV
                     HYWTTFNEPMVIPEAGYLYAFHYPNLKGKGKEAVQVIYNLNLASAKVIQLYRSLGLDG
                     KIGIILNLTPAYPRSNSPEDLEASRFTDDFFNKVFLNPAVKGTFPERLVKQLERDGVL
                     WSHTEKELQLMKSNTVDFLGVNYYHPKRVQAQANPEEYQTPWMPDQYFKEYEWPERRM
                     NPYRGWEIFPKAIYDIAMIVKEEYGNIPWFISENGMGVENEARFIDENGVIDDVYRIE
                     FYEEHLRWLHKAIEEGSHCFGYHAWTAFDCWSWNNAYKNRYGFISVDLETQKRTIKSS
                     GRWYRKVSDNNGFEVEIEE"
     gene            2669..3964
                     /locus_tag="VVR18_002102"
     CDS             2669..3964
                     /locus_tag="VVR18_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000798148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEU6033555.1"
                     /translation="MKNSKFIDQFAIFAGKLGNQIHLKTLRDAFVTVMPLYILAGLIV
                     LLNNTVFKWIFQGDTLTKFQYWGITIANGTLSISGMIIAVMVGYFLAKNRDFENPLAA
                     SMLSLVSLIVMMPNTVSVVPDGAKDAVNISGVLSFNNTGTGAMFAGVIVAIIATELFI
                     ELSNVKALQMNLGENIPPAVSRSFSVLLPVMTVISLFGIVSALLFNITGMNLISIITI
                     FIQEPIRHIGTSLIGVIIIYSLGNMLWLFGIHQAVIYSAILEPLLLINITENITAANN
                     GQAIPHIINLSQIQTFALMGGSGSTLCLLIATFLVSRNAVSKNVAKLSFGPGIFNINE
                     PVLFGYPIVYNISLAIPFITVPVLGILISYLATVTGFMSPAFIQVPWTTPVFLNAWLA
                     TAGDVRAVLVQFIIFALGVLLYIPFIKVNDKVVEQEMEG"
     gene            3969..4277
                     /locus_tag="VVR18_002103"
     CDS             3969..4277
                     /locus_tag="VVR18_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU6033556.1"
                     /translation="MKQILLVCNAGMSTSMLVKKMQQSATERGIEISIQAKSMTEAKK
                     NIHEADVILIGPQIRYELLAVKEIAGNIPVDTIDMRDYGMMNGAKVLEQALAWIGEIR
                     "
     gene            4274..4582
                     /locus_tag="VVR18_002104"
     CDS             4274..4582
                     /locus_tag="VVR18_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU6033557.1"
                     /translation="MTEEMEYICFQLIANSGAAKSSFIEAIQLAKAGNLKEAKIKVEE
                     AEDSLVEAHKIHSNLIQKEATGEKIGFSLLFMHAEDQMASTEIIQLLSKEFIDLYQNK
                     "
BASE COUNT         1752 a          880 c          946 g         1632 t
ORIGIN      
        1 agattgaaat tcatttctag caatttttta gaagtcacag tctactattc taacctcaat
       61 atactatatg tgttacaaga aaagactcaa aaacttctcg tcagtgtaag aatgtttgaa
      121 acactattta aaactaaata actataagaa gtagatcagg tgaacaattt cagtacctac
      181 tctataagct atacgaagat atttttcaac atgatggata aaacgatcac tcttttaaag
      241 tcatcttatt tagaaaagag aaaccattta agcatagatg ggaccttctt gccctgtttt
      301 aaatttttct taaactagag cctgtaaaag attggcttca ttttcacatt ttctcctagg
      361 aggaatgtcg taatgcaaaa gaattaaatt caaataaatc atagcgatga cgactaatcg
      421 agtactcaaa cggagttccg ttatccaaat aagccacttg ttctacttca aataccggtt
      481 ccgttggaag gagctgcaag taatgttgct cattttctga actagaagaa gctcgtaaga
      541 tttttgtagc actggcaata tgcaatccta actttccttc aatgtaattg taaatcgatt
      601 tttgtaaaat atcttcagta atacctggaa taacatcggt actcatataa gtttgttcca
      661 gaacataagg tttaccgtca ataatacgca ggcggtaaat attataaact ggactctgca
      721 aagcgacctg tagtttttct gctaaaaatt catttgcaaa ttctaatttg aagtgaataa
      781 tcctcgagtc aattgtagaa tgagcatctt cagatatttt tgtcagtccc cggatatctc
      841 tttctggaac gattaatttt ctttttgagc tgccacgaga gagaacaaag gttccctgcc
      901 cacgttttct aaaaattaag ccctcagaaa ctaacaagtc taaagctttt ttgatcgtca
      961 ttcgactaca ggcaaactgt ttagctaatg tcatttcatc aggcaattgt tcgttcatgg
     1021 tatatttatt acaaagaatc ttttcacgaa tctcattgta aataaataaa tattttgtac
     1081 tcatttaatc tggttctctc tataatattc taatagtagt ataacaaagt tcaagaaatg
     1141 aggcaaacac aagatatgta tcaacaattt ttaaaaatgt ctagacaaat tttaaaatta
     1201 tgctatactt tatgtatagg ataatagaaa ggaggttgag catgaaaaaa aagttagtat
     1261 ttcctaatct gttttggtgg ggagctgctt ctagcggacc tcagacagaa ggtcaatatg
     1321 gaaaagtaca tgaaaatgcg atggactact ggttcaaaac gcatccagaa gattttttcg
     1381 ataatgtcgg acctcttgta gccagtaact tttttcatac ttacaccgaa gatttccact
     1441 tgatgaagga aattggagtt aattctttcc gcacttccat ccaatggagt cgactcatca
     1501 agaatttaga gacaggtgag cctgatccaa aaggtattgc tttctacaat gccatcattg
     1561 aagaagctaa aaagaaccag atggatcttg tgatgaattt acatcatttt gatttaccag
     1621 tggaacttct tcaaaaatac ggtggttggg aaagcaaaca tgtagtggag ttattcgtga
     1681 agtttgccaa gactgctttc acatgctttg gagataaggt tcattactgg acaactttca
     1741 atgagccaat ggtcattcca gaagcaggat acttatatgc tttccattat ccaaatctaa
     1801 aaggaaaggg aaaagaggcc gtacaagtca tctataatct aaaccttgct agtgcaaaag
     1861 tgattcaact atatcgctca ttaggacttg atggaaagat tgggattatt ttaaacttga
     1921 cacctgctta tccaagaagt aattctccag aagacttaga agcaagtcga tttacagatg
     1981 acttctttaa caaagtcttc ttgaatccag ctgttaaagg aactttccca gaaagattgg
     2041 taaaacagct agagagagat ggcgtgttat ggagtcatac cgaaaaagag cttcaactga
     2101 tgaaatcaaa tacggttgat tttcttggag taaactacta ccatccaaaa cgtgttcaag
     2161 cacaagcaaa tcctgaggaa tatcagacgc cctggatgcc agaccaatac ttcaaagagt
     2221 atgaatggcc ggagcgtcgc atgaatccat atcgtggttg ggaaattttt ccgaaagcca
     2281 tttatgatat tgctatgatt gtgaaggaag aatatggtaa tatcccatgg tttatcagtg
     2341 aaaacggaat gggtgttgaa aacgaagcac ggtttatcga tgaaaatgga gttatcgatg
     2401 acgtgtatcg tattgaattt tatgaagaac atttaagatg gctacataaa gccattgaag
     2461 aggggagtca ctgttttgga taccacgctt ggaccgcatt tgattgctgg tcttggaata
     2521 atgcatataa gaatcgttac ggatttatct ccgttgattt agaaacgcaa aagagaacca
     2581 tcaagagctc aggaagatgg tatcgcaaag taagtgacaa caacggtttt gaagtagaaa
     2641 ttgaggagta aagagaggag atattcagat gaaaaactca aaatttatag atcaatttgc
     2701 catctttgct ggtaaactag ggaaccaaat tcatttaaaa accctaagag atgcattcgt
     2761 aacagtaatg ccattatata ttttggcagg tttaatcgtt cttttgaaca acacggtatt
     2821 taagtggatt ttccaagggg atacattaac aaaattccaa tattggggaa taacaattgc
     2881 aaacggtact ttaagtattt caggtatgat tattgctgta atggttggtt atttcttagc
     2941 taaaaacaga gatttcgaaa acccgttagc agcatcaatg ctatcattag tttctttaat
     3001 tgtgatgatg ccaaatacag tttctgtagt tcctgacgga gcaaaagatg ctgtaaacat
     3061 ttcaggtgtt ctttcattca acaacacagg tacaggcgca atgttcgccg gggttatcgt
     3121 agcgattatt gcaacagaat tattcattga attatcaaac gttaaagctt tacaaatgaa
     3181 ccttggtgaa aatattccac cagctgttag tagatcattt agcgtattac ttccagtcat
     3241 gactgtcatc tccttatttg ggattgtttc agcattatta ttcaatataa ctggaatgaa
     3301 cttaatctca atcattacaa tctttattca agaaccaatt cgtcatattg gtacaagctt
     3361 aatcggggtc attattattt actctttagg aaatatgtta tggctatttg gtattcacca
     3421 agcagttatt tacagtgcca tcctagaacc attactatta attaacatta ctgaaaacat
     3481 cactgcagca aataatggac aagccattcc acacatcatc aacttatcac aaatacaaac
     3541 attcgcttta atgggtggta gtggatctac attatgttta ttaatagcaa cattcttagt
     3601 gagtcgcaat gctgtttcta aaaacgtggc taaattatct tttggacctg gtatcttcaa
     3661 tatcaatgaa ccagtattat tcggttaccc aatcgtttat aacatttcat tagctattcc
     3721 atttatcaca gttccagtcc ttggtatttt aatcagctac ttagcaacag ttacaggatt
     3781 catgagtcct gcatttatac aagttccttg gactacacca gtattcttaa atgcatggtt
     3841 agcaacagca ggggacgtga gagcagttct agttcaattc atcatctttg cacttggagt
     3901 tcttctatac attccattta tcaaagttaa tgacaaagtt gttgagcaag aaatggaagg
     3961 ttaagattat gaaacaaatt ttattagtat gtaatgcggg aatgtcgaca agtatgcttg
     4021 ttaaaaaaat gcaacaaagt gcgactgaac gtgggattga aatctctatc caagcaaaat
     4081 caatgacaga agctaaaaag aatatccatg aagcagatgt cattctaatt gggccacaaa
     4141 ttcgttatga gttacttgct gtgaaagaaa ttgcaggaaa tatccctgta gataccattg
     4201 atatgcggga ttacggaatg atgaatggag caaaagttct ggaacaagca cttgcatgga
     4261 taggagaaat aagatgacag aagaaatgga atatatctgt tttcagctca ttgccaatag
     4321 tggagcagcc aaatcatcct ttattgaagc catccaacta gctaaggcag gaaatttaaa
     4381 agaagcgaaa attaaagttg aagaagcgga agactcctta gtagaagcgc acaagattca
     4441 ctctaatctc atacaaaaag aagctactgg agaaaaaata ggattctcct tgctatttat
     4501 gcatgcagaa gaccaaatgg cttcaacaga gattattcag ttactatcta aagaattcat
     4561 cgatctctat caaaataaat aggaacactg tcattcccat ctgtctttat taatgacgac
     4621 tacattgtag gaacctccaa aagttggaca aaatgattga aaggattgga tcctgcatta
     4681 cacaagatcc aatccttttc ttttactcta gtttttataa tatgttgaat ctagaatagt
     4741 ccactgcagt ttctaaaaaa tttctggaaa tggatgttaa gctccaattt atttgtttat
     4801 atcttatttc agtttactat actagcttat tattctagtg aaaaattgaa tgagccacta
     4861 tttatttaat atgtatgatg agggaatgac tcaaaaactt cttgtcgata taagaacatc
     4921 tgagatagta ttttaaaacg aaaggactat aaaagctcat ttccttcgca cttattttat
     4981 agagatctat cattatactc tttagaaatc aaaaagcaac acaccttgtc atcgttttat
     5041 cgtaaatctg ttaatgaggg ggctagtctt atctgcaatc tcaaatcagt gttttgagct
     5101 gaatggcact cgttttctcg tttgctcttt gattttaatt gggccttagt aaatactact
     5161 cttaaattaa actatagtga attgaaataa gatgtgaaca actctatcag
//
LOCUS       DAVHSO010000093         5189 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.094, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000093 DAVHSO010000000
VERSION     DAVHSO010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5189)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5189)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5189
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.094"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            153..290
                     /locus_tag="VVR18_002105"
     CDS             153..290
                     /locus_tag="VVR18_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="HEU6033558.1"
                     /translation="MAEEVLNLQLVSVQVDETDEVDGMRFSTFSTNRCGNWSAFSWEN
                     C"
     gene            525..2171
                     /locus_tag="VVR18_002106"
     CDS             525..2171
                     /locus_tag="VVR18_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033559.1"
                     /translation="MYTIGNQITEVLHEHYDISKEEANKRAIEMLEKLGIHNAAERMN
                     DYPHQFSGGQRQRIVIAIAMVCNPDILIADEPTTALDVTIQAQILDLLDDLRKEHGTS
                     IILITHDLGVIAQIADEVAVMYAGEVVEVGTVAQIFDQPKHPYTRSLLRSIPNPENMD
                     KKLHVIQGSVPSISEISEKGCRFANRIPWLEKEHHEEEPQLHDLGDGHFVRCSCYKHF
                     FFEDKEEETLAEKHVGNVVLEVKNIKKYYYPKKQLFKPLGSPLKALDDVSLELRKGTT
                     IGIVGESGSGKSTIAKSLMKLHDITDGEINIDLNGKTQNIYGIKRKEDLDFRKKVQMV
                     FQDPYASLNPTKKIYNSFDEPMIVHNIGNKEERFERMKEALKMVNVPVEYLERYPHEF
                     SGGQRQRLCIARALCMKPEILILDEPVSALDLSVQAQVLNYLVEIQNKEDLTYVFISH
                     DLGVVKYMCDYLYVIHKGRIVEAGSREDIYNNPMHIYTKKLLAAIPEVDYHFKEALAT
                     KRKENEVEFKAQYHEFYDEDGRAYDLKQVSPTHFVALKPE"
     gene            2181..3590
                     /locus_tag="VVR18_002107"
     CDS             2181..3590
                     /locus_tag="VVR18_002107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033560.1"
                     /translation="MKLNKKIYFFDKGIFNPYRMSNVKLKVNQAVKDKEIFFTEEKPW
                     EIRFDNSYPNVFFDDLAGVYRCYYSTFTDDEESEKYSLEERKERQYLPRAKRIVSLCY
                     AESKDGVNWVKPNLGITEFRGSTENNIIGHFLHGTSVFLDKHDADENRRYKMFTKIDY
                     GNGVHFIAVAFSKDGLHFDEYIKVPNFNPRADTHNHIIYDEALNRYVLITRTWRDSLR
                     LPCVSTSADFINWTPIQEILNVCDYENQIYSMPIFKRGDYILGLASVFHEGDQLNKNY
                     DTVDLQLTYSYRHVGWHYLNTDTPLIPRGKGQYGDGEFDCGCIYSSAPVTIGDRTYFY
                     YMGGNGQHTNFRETSLSRAYIEKDHFAYWDTKRPEYPGVLYTNGFIFLNDQVYLDADI
                     AAGGFVTIELFENNHTPMEITASLEKIEDGRYQVLFSEPLPRTQTRLKISFKNAKIYA
                     IEGNLDIFRIESDNALLRG"
     gene            3595..4083
                     /locus_tag="VVR18_002108"
     CDS             3595..4083
                     /locus_tag="VVR18_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidylglycerophosphatase A"
                     /protein_id="HEU6033561.1"
                     /translation="MKYDLYDNCIELLKEREVTIEDMAALVIFSQQKYYPELTLDDAS
                     YAIQRVLKKREVQNVIMTGIELDKLAEAQKLSPEFQKIMEKDNPLYGIDEVIVLSILN
                     LYGSIAFTNYGYLDKLKPLILERLNENHEGVCNVFLDDIVGAIAAAACSKIAHNHASD
                     EI"
     gene            4371..4778
                     /locus_tag="VVR18_002109"
     CDS             4371..4778
                     /locus_tag="VVR18_002109"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000216069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEU6033562.1"
                     /translation="MTVINKFVLMEQAKKVLKNAYCPYSKFPVGAAILFKDGKVITGA
                     NIENVSFGVTNCAERSAIFYGASQGYRKGDILAIAVAGETEDYLPPCNICRQVMVEFC
                     EPDTLVFLLNGKGNILELRLEELVPYSFSSLEM"
     gene            4810..5189
                     /locus_tag="VVR18_002110"
                     /pseudo
     CDS             4810..5189
                     /locus_tag="VVR18_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
BASE COUNT         1762 a          757 c         1005 g         1665 t
ORIGIN      
        1 tgcaaaaatt atttcttaaa aatttgtaag ttttcgctat ataaaatagt taaatctatt
       61 ttgtatcatt gcttgcattt tactggtgga gagaatataa tgagggtgga taaagtactt
      121 aatcccaaaa atttaaatag gaggagctag ctatggcaga agaagtatta aatcttcaat
      181 tagtatctgt tcaagttgac gaaacagatg aagttgatgg aatgcgattt agtacattca
      241 gtacaaaccg ttgcggtaac tggagtgctt ttagttggga aaattgttaa ttcatttaaa
      301 ttgtaaactt tagggattct ctgaagttat ggatgtcgtt ccaatatgtg tacgttggaa
      361 tgttagtgct tatatggggg gaacagaatc ctctcttgat tgaagacaag ttagccatta
      421 ggctggtttg tctctttgtc aactgtagtg ggttgatata atagtattag tgagtgggat
      481 aaaagtttca tttagtttat tcagtacaaa tttaacgggt caagatttat acaattggta
      541 atcaaattac tgaagtcctt catgaacatt atgacatttc taaagaggag gcaaataaac
      601 gtgctataga aatgttagaa aaacttggaa ttcataatgc tgcagaacgc atgaatgact
      661 atccacacca atttagtgga gggcagcgtc aaagaatagt catagcgatt gcaatggtat
      721 gtaatccaga tattctaatt gcagatgaac caacaactgc ccttgatgta acaatccaag
      781 cacaaatact tgatttactt gatgatttac gtaaagagca tggaacttct attatcttaa
      841 ttactcacga tttaggcgtt attgctcaaa ttgcggatga agttgcagtg atgtatgctg
      901 gtgaagtcgt tgaagttgga actgtagctc agatctttga tcaacctaaa cacccgtata
      961 ctcgttctct attaagatct attcctaatc ctgaaaatat ggataaaaag ctacatgtta
     1021 tccaggggag cgtaccttca atttctgaaa tatctgaaaa aggatgcaga ttcgcaaatc
     1081 gtattccatg gttagaaaaa gaacatcatg aagaagaacc tcaattgcat gatttaggtg
     1141 acggacattt tgtaaggtgt tcttgctata aacatttctt tttcgaagat aaggaagaag
     1201 aaacattagc ggaaaaacat gtaggtaatg ttgttttaga agtaaaaaat attaaaaagt
     1261 actactatcc taagaagcaa ctattcaagc cactaggttc tccgttgaaa gcacttgatg
     1321 acgtatctct agagttaaga aaaggaacta ctattggtat cgtaggagag tctggaagcg
     1381 gtaagagtac gattgcgaaa tcattaatga aactccatga tattacagat ggtgaaatca
     1441 atattgattt gaatgggaaa actcaaaata tttatggaat taaacgtaag gaagatttgg
     1501 atttccgtaa gaaagttcaa atggtattcc aagatcctta tgcatcattg aacccaacta
     1561 agaaaattta taattcattt gatgaaccga tgattgtcca taatattgga aacaaagagg
     1621 aacgctttga acgtatgaaa gaagccttga agatggtaaa cgtgccagtt gagtacttgg
     1681 agcgttatcc tcatgaattt tcaggcggac aacgtcaacg tttatgtatt gctcgtgccc
     1741 tttgtatgaa accagaaatt ttaattttag atgaacctgt ttcagcatta gatctatctg
     1801 tacaagcgca agttttgaat tatcttgttg aaatccaaaa taaagaagat ttgacttatg
     1861 tatttatttc tcatgaccta ggtgttgtga aatacatgtg tgactatcta tatgttattc
     1921 ataaaggacg tattgtagaa gctggttctc gagaagatat ctacaataac ccaatgcata
     1981 tttacactaa aaaactatta gctgctattc cagaagttga ttatcacttc aaagaggcat
     2041 tggcaacaaa acgtaaagaa aatgaagttg aatttaaagc acagtaccat gaattttatg
     2101 atgaagatgg ccgtgcttat gatcttaagc aggtttcacc aacacatttt gtagcgttaa
     2161 aaccagaata ggtggtaaat atgaaattaa ataaaaaaat atatttcttt gataaaggaa
     2221 tttttaatcc ttatcgaatg agtaatgtaa aattaaaagt taatcaggca gtaaaggata
     2281 aagaaatttt cttcactgag gaaaaaccat gggaaattcg ttttgataac agttatccaa
     2341 atgttttctt tgatgattta gcaggtgttt atcgttgcta ctattctaca tttactgatg
     2401 atgaggagtc tgaaaaatac tctttagagg agcgtaagga acgtcaatat ctacctcgtg
     2461 cgaagcgtat tgtttcactt tgttatgctg aaagtaaaga tggtgttaac tgggtgaaac
     2521 caaatctagg tattacagaa tttcgaggat caactgaaaa taatattatc ggacattttt
     2581 tacatggtac atctgttttt ctagataaac atgacgcaga tgaaaatcgt cgttataaaa
     2641 tgtttacaaa gattgattac ggtaacggtg ttcatttcat tgctgtagca ttttcaaaag
     2701 atggtctaca ctttgatgaa tacattaaag taccaaactt caatccacgt gcagacactc
     2761 ataaccatat catatatgat gaagcattaa atcgctatgt gctaattact cgtacttgga
     2821 gagattcatt gcgcttgccg tgtgtatcta cgagtgctga tttcattaac tggactccaa
     2881 ttcaagaaat tttgaatgtc tgtgattatg aaaatcaaat ttattctatg cctattttta
     2941 aacgtggcga ttatatacta ggtttagctt cagttttcca tgaaggagat caactgaaca
     3001 agaattacga tacagtggac cttcaattga cttatagtta tcgtcatgtt ggttggcatt
     3061 atctaaacac tgatactcca cttattcctc gtggtaaagg tcaatatggt gatggagaat
     3121 ttgactgtgg atgtatctat tcttctgcac cagttactat cggtgaccgt acttatttct
     3181 actacatggg aggaaatgga caacatacaa acttccgtga aacaagcttg tctcgtgctt
     3241 atattgagaa agatcacttt gcatattggg atactaaacg tccagaatat ccaggtgttt
     3301 tgtataccaa tggatttatt ttcctcaatg atcaagttta ccttgatgca gatattgcag
     3361 ctggaggctt tgtaacaatt gaattgttcg agaataatca cactccaatg gaaattacag
     3421 cttcccttga aaaaatagaa gatggtcgct atcaagtgtt attcagcgaa cctttacctc
     3481 gaactcaaac tcgactgaaa attagcttta aaaatgctaa aatctacgca atcgaaggaa
     3541 atttagatat tttcagaatt gaatcagaca atgctctatt gagggggtaa gattatgaaa
     3601 tatgatttat atgataattg tattgaactt ctaaaagaac gcgaagttac aattgaagat
     3661 atggcagcgt tagtaatatt ttcacaacaa aaatattacc ctgaattaac tcttgacgac
     3721 gcttcatatg caattcaacg tgtactaaaa aaacgtgaag ttcagaatgt aattatgaca
     3781 ggaattgagt tagataagtt agctgaagca caaaaactat ctccagaatt tcaaaagatt
     3841 atggagaaag ataatccatt gtatgggatt gatgaagtaa tcgtcttatc gatattgaat
     3901 ttatatggtt ctattgcctt tacaaattat ggctatttag ataaattaaa accactgatt
     3961 ttagaaagat tgaatgagaa tcacgaaggt gtttgtaatg tatttctaga tgatattgtt
     4021 ggtgcaatag ccgcagcagc atgtagtaaa attgcacaca atcatgctag tgatgaaata
     4081 taactattga atttagtatc gtaaataata aagcgtttgg tttctagatt attgtcattc
     4141 aaattggata atgataaatc tagaaaccaa atatattttc cgcataaaat gagggattat
     4201 atatctcact tttttacaat tgtatagtgg attaaaacta gaatagtgca tctctacttc
     4261 taaaacattg ttagaaatcg atttgactgt cctgattgat ttgtactgtt cttatttcat
     4321 tttactataa tttagtgtga gtaaaatata ataataaagg agttaaaaca atgacagtaa
     4381 ttaataaatt tgttttaatg gagcaagcaa aaaaagtttt aaaaaatgct tactgtccgt
     4441 attccaaatt tcctgtaggt gcagcaattt tatttaaaga tggtaaagta attacaggag
     4501 caaatataga aaatgtatcg tttggtgtaa ctaactgtgc agaacgtagt gctatttttt
     4561 atggggcttc tcaaggatat agaaaaggag atattcttgc gattgctgtt gcaggtgaaa
     4621 ctgaagacta cttaccacca tgcaacattt gtcgtcaagt tatggtagaa ttttgtgagc
     4681 ctgatacctt agtctttcta ttaaatggta agggaaacat acttgaattg cgattagagg
     4741 aattagtccc atattcgttc tcaagtctag aaatgtaatt acgtagtatg aaataaggag
     4801 aaaaaaacaa tgtcagattt gaaaaaatac gaaggtgtca ttccagcctt ctacgcatgt
     4861 tatgatgagc aaggagaagt aagtccagag cgtacgcgtg cctaggttca atacttcatt
     4921 gataaaggtg ttcaaggtct ttatgtcaat ggttcttctg gtgaatgtat ctaccaaagc
     4981 gttgaagatc gcaagttgat tttggaagaa gtcatggcgg tagccaaagg taaattgacc
     5041 attattgccc atgttgcttg caataatact aaagatagta tggaacttgt tcgccatgct
     5101 gaaagcttgg gagtagatgc tattgcaacg attccaccaa tttacttccg cttgccagaa
     5161 tactcagttg ccaaatactg gaacgatat
//
LOCUS       DAVHSO010000094         5034 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.095, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000094 DAVHSO010000000
VERSION     DAVHSO010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5034)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5034)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5034
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.095"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(252..632)
                     /locus_tag="VVR18_002111"
     CDS             complement(252..632)
                     /locus_tag="VVR18_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0115 family bacteriocin-like peptide"
                     /protein_id="HEU6033563.1"
                     /translation="MELVLPNNYVALEQEEMMYLDGGGVGRNWWNSRGSFATVLDVGL
                     AIYSGGATIYSAYAIKKAISANRGAITRTLRSLIIKHVGSAAGHLVNTALNVALTVTG
                     FSLGGAIAYGADWADGSLDGYIFA"
     gene            complement(778..2130)
                     /locus_tag="VVR18_002112"
     CDS             complement(778..2130)
                     /locus_tag="VVR18_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="HEU6033564.1"
                     /translation="MKLYNKSELRYSRIFFDKRPPAFAFILIISTAIILSGALVGAAY
                     IPKNYIVKANGNSVITGTEFLSAIGSGKVVTLHKSEGDMVNAGDVIISLSSGQEGLQA
                     SSLNKQLEKLRAKEAIFQKFEQSLNEKYNHLSNSGEEQEYYGKVEYYLSQLNSENYNN
                     GTQYSKIQDEYTKLNKITAERNQLDADLQTLQNELIQLQQQGDSSSLSDTTSDDDKAK
                     LETKISEITTKIEALKTNITSKNSEIDSQQSNIKDMNRTYNDPTSQAYNIYAQLISEL
                     GTARSNNNKSITELEANLGVATGQDKAHSILASNEGTLHYLVPLKQGMSIQQGQTIAE
                     VSGKEKGYYVEAFVLASDISRVSKGAKVDVAITGVNSQKYGTLKGQVRQIDSGTISQE
                     TKEGNISLYKVMIELETLTLKHGSETVILQKDMPVEVQIVYDKETYLDWILEMLSFKQ
                     "
     gene            complement(2127..2594)
                     /locus_tag="VVR18_002113"
     CDS             complement(2127..2594)
                     /locus_tag="VVR18_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEU6033565.1"
                     /translation="MAKLEVKDNKKLVLKSVICKKLHDTKVEDVDQEINKFHQHLQLL
                     KAQIFGPLIVKSCGTTIHDDGLITTDFEFYIQAHNAQQYSNIYDVQDSISVPYCLYVR
                     FEDSPEYLQYAYSKLDLYVYENDIQTDGIVYTVYVNSSPEKMVVDIFRPIVSL"
     gene            complement(2587..4806)
                     /locus_tag="VVR18_002114"
     CDS             complement(2587..4806)
                     /locus_tag="VVR18_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001856353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="HEU6033566.1"
                     /translation="MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTD
                     MYGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIK
                     RNSKFYVADPASGIRKMSSDELGEIYQGITLFMVPNSDFERGKLKGKGLLDLFGRLIF
                     NQKGLISTVILASFVLSIIGILSSLFSKVIMDEVIPYALKNSLYMFLIVFGIVSFLQT
                     LLSAFRQHVLLFLSRKIDIPVLMGYYDHIIHLPYSFFGSRRVGDVLTRFQDAMTIKNV
                     FTSVSISLVMDITLSVISAVVLWTINQSLFLILVFMVIVNIILIYCFKKPYKKINHEQ
                     MEANGLLNSQLIESIRNIDTIKSQHDEEQRLNKIEEKFVHTLEIGYKEGVLQNIQSTI
                     SSMTSTMGGLLFMGVGALFIIDGKMTIGDLLVFQTLSQYFTEPIQNLVGLQLTFQEVQ
                     VAVSRLQELMEVDREDIALDYSIRDFTLCDDIEFKDVTFAYGSRPPVIKDFNLRIKQG
                     EKIAFVGESGAGKSTLVRLLLRFINPSEGKIRIGENDLSDLDYGKLRKKISYIPQTIE
                     LFTGTIIDNLKIGNPSVTYEDMVRVCRIVGIHDTIQRLQNRYGSFVEEDGQNFSGGEK
                     QRLAIARALLSKADLYIFDEATSNLDSFSEQIIQDLIFNKIMDKTTIVVAHRLSTILR
                     CDKICFLENGTIVEYGTHEELMAKNGKYARMVGLQSVQVNQQIQSQAVLDTEEVTYG"
BASE COUNT         1634 a         1009 c          685 g         1706 t
ORIGIN      
        1 taatctacca acctcttgtt tttaaataca tttcaagtcc aaactattct ttatagaaaa
       61 aagtcctata aattcgagca atagttaaaa tacaaacaaa tataattccc aaaatagata
      121 acactatttt cacaaaattc atttcagaac ctattatata tacgtgaaaa aaaggggcta
      181 ttcctacaca tatatacaat aaataactta caaagtttat ttcaccaatt cctgcaaaaa
      241 aatgtttcat tttaagcaaa aatataacca tctaagctac cgtcagccca atcagcccca
      301 tatgcgattg ctccacctag tgaaaatcca gtaacagtta gtgcaacgtt tagtgcagta
      361 ttgactaaat ggccagctgc actacctaca tgtttaatta ttaaactacg taatgttctc
      421 gtaatagccc ctctattagc tgagatagct ttttttatcg cataagcaga ataaattgtt
      481 gcaccaccac tatagatggc caaacctaca tccagaactg ttgcaaaact acctctacta
      541 ttccaccagt tacgaccaac accaccccca tcaagataca tcatctcttc ttgctcaaga
      601 gcaacataat tatttggtaa tacgagttcc atttattttc tcctttttta ttaagcatgg
      661 ttaggatagt ttcctaacaa gtgagcatcg actttgttta tagcacttag ttacctagat
      721 aagatatctt ccctttatct tactttattt tataggtgac ttaatgttta aaaccaatta
      781 ttgcttgaaa cttaacattt ccaaaatcca atcaagatag gtttctttat catagacaat
      841 ctgcacttca actggcatat ccttttggag tatgaccgtc tcgcttccat gttttagagt
      901 taaggtttct aattctatca tgactttata gaggctaata ttcccctctt tcgtttcttg
      961 ggaaattgtt cctgaatcaa tctgtctgac ttgtcccttt agtgttccat atttttgact
     1021 atttacacca gtaatagcaa catcaacttt tgctcctttt gagacacgag aaatatcact
     1081 cgcaagtaca aaagcctcta catagtaacc tttttctttc cctgaaactt ctgctatcgt
     1141 ttgcccctgc tgaatagaca ttccttgttt caaaggtacc agataatgca gagtaccttc
     1201 atttgacgct aatatactat gagctttatc ttgacctgtt gccactccaa gattagcctc
     1261 aagctctgta atacttttat tgttgtttga acgagcagta cctaactcac taattaattg
     1321 agcataaata ttataagcct gagaagttgg atcattatag gtacggttca tatccttaat
     1381 attgctttgt tgactatcaa tctcgctatt cttagaagta atatttgttt ttaatgcttc
     1441 gatttttgtt gttatttctg atatcttagt ttctaactta gctttatcat catctgatgt
     1501 cgtatctgat aaggaggatg agtctccttg ctgttgaagt tgaatcaatt cattttgtag
     1561 agtttgcaag tcggcatcta actgatttct ttcagctgtt attttattca acttcgtata
     1621 ttcatcctga atctttgaat actgggtacc attattataa ttttccgagt ttaactgaga
     1681 cagatagtat tcaactttcc cataatattc ctgttcttca ccagaattag ataaatgatt
     1741 gtatttctca tttaatgatt gttcaaattt ttgaaagata gcttcttttg cacgtaactt
     1801 ctccaattgt ttatttaaag agctcgcttg taaaccttct tgtccacttg ataacgaaat
     1861 aatgacatct ccagcattta ccatatctcc ttctgactta tgtaaagtaa ctaccttccc
     1921 tgaaccaatt gctgatagga actctgtacc tgttataact gaatttccat tcgcttttac
     1981 aatatagttt ttgggtatat aagctgcgcc aaccaatgca ccgcttaaga taatagcagt
     2041 tgaaataatg agaataaacg caaaagctgg tggtctctta tcaaagaaaa tacgagaata
     2101 acgtaattct gatttattat ataatttcat aggcttacaa ttggtctaaa aatatctact
     2161 accatttttt caggagaaga attaacataa actgtataga caatcccatc cgtttgaata
     2221 tcattttcat agacatatag atccaattta gaatacgcat actgtagata ctctggactg
     2281 tcttcaaaac gaacatataa acaatatgga acagagatag aatcctgtac atcataaatg
     2341 ttactgtact gttgagcatt atgagcttga atataaaact caaaatcagt cgttattaat
     2401 ccatcatcat gaatagtagt accacaactt tttacaatta atggaccaaa aatttgtgct
     2461 tttaacaact gcaaatgttg atgaaattta ttaatttcct gatctacatc ttctactttt
     2521 gtatcatgta actttttaca gataactgac tttagtacca gttttttatt atcttttacc
     2581 tctaacttag ccataagtaa cctcctctgt atctaacaca gcctgtgact gaatttgttg
     2641 attcacttga acgctctgca aaccaaccat tctagcatac tttccatttt tcgccattag
     2701 ttcttcatga gtcccatatt ccacaatagt cccattttct aaaaagcata tcttatcaca
     2761 tcgaagaatt gtagacagcc tgtgggctac tacaattgtt gtcttatcca ttattttatt
     2821 aaagattaaa tcctgaataa tctgttcact aaatgaatct aagttagagg ttgcctcatc
     2881 aaatatatac aaatcagctt tactcagtag tgctcttgca atagccaatc gttgtttctc
     2941 tccacccgag aaattttgac cgtcttcttc tacaaaggag ccataacgat tttgaagacg
     3001 ttgaatcgta tcatgaatac caacaatacg acaaactctc accatatcct catatgtaac
     3061 agaaggatta ccaattttta gattatcaat aattgtccct gtaaagagtt ctatggtctg
     3121 aggaatgtag gaaattttct tacgtagttt accatagtca agatctgata agtcattttc
     3181 tcctatacga attttcccct cactcggatt tataaatctt aataacaaac gaactagcgt
     3241 actttttcct gctccgcttt ctccaacaaa agctattttt tctccttgtt taattcgcaa
     3301 attaaagtcc ttgataacag gagggcgtga accataggca aatgttacat ctttaaattc
     3361 aatgtcatca cataaggtga agtctctaat actataatcc aaggcaatgt cttcacgatc
     3421 tacttccatc aattcttgaa gccgactaac cgcaacctgt acctcttgaa aggttaactg
     3481 caagccaact aaattctgaa taggttctgt aaaatattga cttaatgtct gaaaaaccaa
     3541 gaggtcccca atagtcattt ttccatcaat gataaataag gcgcccactc ccataaataa
     3601 taacccaccc atggttgagg tcattgaaga tattgtagat tgaatattct gcaaaacacc
     3661 ctctttataa ccaatttcta aagtatgaac aaatttttct tcaattttgt ttaaacgttg
     3721 ttcctcatca tgctgagact taatggtatc aatgttacga atagattcaa ttaactgtga
     3781 attaagaagt ccatttgctt ccatttgttc atgattaatt tttttataag gctttttaaa
     3841 acagtatata agaatgatgt taacaataac cataaaaact aatatcagaa ataaagattg
     3901 attaatagtc caaaggacaa ccgcactaat aactgacaag gtgatatcca tgactaatga
     3961 aatagagact gacgtaaaca cattctttat cgtcatcgca tcttgaaatc ttgttaaaac
     4021 atcaccaact ctacgacttc caaaaaaact ataaggaaga tgaataatat ggtcataata
     4081 tcccattaaa accggtatat caatttttcg agatagaaac aaaagaacgt gctgacgaaa
     4141 tgcagataga agagtctgta agaacgacac tattccaaat actatcaaaa acatatacag
     4201 actatttttt aaagcatatg gaatcacctc gtccatgata acttttgaaa agagactcga
     4261 taaaatacca atgatactta aaacaaagga agctaatatg actgtactaa tcaatccttt
     4321 ttgattaaaa attaaccttc caaataaatc aagaagtcct tttcccttta gtttccctct
     4381 ttcaaaatcc gaatttggaa ccataaaaag agtaatacct tgataaattt ctcccagttc
     4441 gtcacttgac atcttgcgta tgccactagc agggtctgct acgtagaact tactattcct
     4501 tttgatacta tgtagtacca caaaatgatt ttgacctaaa tcattcttaa cttgaagaat
     4561 cgcaggaaat gttaattttg gagtcaaatc ttccagtgct actcgaacag cttttactgt
     4621 aaaattcaac ttattcagac ctgaaacaat accactgaca gtcgttccat acatgtctgt
     4681 accaataatt tcccgaatct tcatgattga tagttccttt ttgtaagata aaagaactgt
     4741 tgaaacaact gccgcagcac aatctgactg atcatgttgc atcgtacaag gatatttttt
     4801 taacatagaa atactcaatt ctttagaatt aatctaactt ttctttgatg tcacccaaac
     4861 ctcaatcact gcccagtagt tcttgaatca gtttattttc aatcgtatca ttctttgttc
     4921 ttgatatctt tccaagcatt gtagtacagc agatttttgt ccaaggacta agcctccttt
     4981 aacaactcaa gctcccttac attatatcga ccagccccat ggaaagatta tggc
//
LOCUS       DAVHSO010000095         4997 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.096, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000095 DAVHSO010000000
VERSION     DAVHSO010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4997)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4997)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4997
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.096"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(175..1590)
                     /locus_tag="VVR18_002115"
     CDS             complement(175..1590)
                     /locus_tag="VVR18_002115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEU6033567.1"
                     /translation="MTIFPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEA
                     TENPTEDNLKLLGIDFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDKEEPNEAGL
                     KYYDELFDELHAHGIEPLVTLSHYETPLYLARKYHGWIDRRMIHFYEKFARTVLKRYK
                     DKVKYWLTFNEVNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREI
                     NSEFKVGCMVLAMPAYPMTPNPKDVWATHEYENLNYLFSDVHVRGYYPNYAKRYFKEH
                     DINIEFAAEDAELLKNYTVDFLSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESS
                     EWGWQIDPIGLRIILNRYYDRYQIPLFIVENGLGAKDQLIKDEFNNLTVQDDYRIQYM
                     KEHLLQVAEALQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGNGTFNRY
                     KKMSFTWYKGVIESNGESLFK"
     gene            complement(1603..3441)
                     /locus_tag="VVR18_002116"
     CDS             complement(1603..3441)
                     /locus_tag="VVR18_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEU6033568.1"
                     /translation="MSYKDTVQKILDVIGGEKNVNRVTHCVTRLRLELKDENLVNDDD
                     VKKIPGVIGIMKKNGQYQIILGNDVANYYKEFVKLGNFESDSVVQGHKGNILERIIEY
                     IAGSMTPIIPAMLGGGMLKVLVIILPMLGILQSDSQTIAFLTFFGDAPYYFLPLLLAY
                     SASQKLKVTSTLAMSVAGVLLHPNFVQMVQSGNPLSLFGVPVTPASYGSSVVPILIMV
                     WLMKYIEKMIAKLTPAVTKSFLQPTLVLLVSSCIALVVVGPIGVIVGEGLSNLVGQMY
                     GVAGWLTLAILGAIMPFIVMTGMHWAFAPIFLAASIATPDVLILPAMLGSNLAQGAAS
                     MAVALKSKNNNTKQIAFAAGFSALLAGITEPALYGVTLKYKKPLYAAMIGGGLAGLFA
                     GLTSVKAYLFAVPSLIALPQFIYSDVPSNIVNALIVAVISVVITFVLAYIFGIDEEES
                     SSNLEVEVGVSNKKMIFSPISGEIIPLSDVQDKTFSDKLIGDGVAIIPSEGKVYAPFD
                     GKITNIFPTKHAIGLKSDEGVELLIHIGLDTVELKGQGFISHVEEGDRVFKNQLIFEM
                     DLNLIKTKGYETVTPVIVTNTNDFLDVLVLPNNQTIEHSKELLVIL"
     gene            complement(3459..4298)
                     /locus_tag="VVR18_002117"
     CDS             complement(3459..4298)
                     /locus_tag="VVR18_002117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HEU6033569.1"
                     /translation="MIIKRILNHNAVIAQSKKDIDILLFGRGIAFGRKIGDKVNPIDI
                     EKSFFLKNRDNMTRFTEMFINVPLELVYITEKIINLGKITLGNNFDEIIYINLTDHIS
                     SSIERYKEGVIISNPLRWEISKYYKEEFELGKRALQIIKKELGIELPIDEAAFIALHF
                     VNANLENNFQESYKITEIIMGIEKIIQDFYCTEFNQDSIDYYRFITHIKLFAHRLVEN
                     TTYCDDDDEDLLALMKNKYPREYECGEQVAMFIQTEYNYLLTSSELVYLMAHIRRLTK
                     NLD"
     gene            complement(4599..4781)
                     /locus_tag="VVR18_002118"
     CDS             complement(4599..4781)
                     /locus_tag="VVR18_002118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000842022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HEU6033570.1"
                     /translation="MKSQKIKVSFTQSKIVTPILLVNKTIVWYGAMPLLGEVDEMTIL
                     RLESASIVSELVAGLR"
     gene            4840..>4997
                     /locus_tag="VVR18_002119"
     CDS             4840..>4997
                     /locus_tag="VVR18_002119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033571.1"
                     /translation="MKLTYDDKVQIYELRKQGYSLEKLSNKFGINNSNLRYMIKLIDR
                     YGIEFVKKG"
BASE COUNT         1688 a          960 c          659 g         1690 t
ORIGIN      
        1 aaccaatcta tcctaagtta actatttata atcggctctc tgtaacaaaa ttaaattaat
       61 taatccccct atgaaataaa gaggtttaga atttgatgtc ttccaaacct ctttatttca
      121 tattcaatga gatgttgcct taaccgtgat aatatctaat catcaataaa caaactattt
      181 gaataaggat tctccatttg attcaatcac tcctttatac caagtaaagg acattttctt
      241 atatcgattg aatgtgccat ttccatcatc atttcgatca acataaatga gaccgtacct
      301 cttagaaagc tgtgcagtgg acatagaaac gcagtcaata catccccaag acgtatagcc
      361 cataatttcc acaccatctt gtagagcttc agctacttgc aataaatgtt ctttcatata
      421 ctgaattcta taatcatctt ggactgttaa gttattaaat tcatctttta ttagttgatc
      481 tttagcacct aatccgtttt ccactataaa taatggaatt tgataacggt cataatatct
      541 atttaaaatt atacgtagtc caattggatc aatttgccat ccccactctg aagactctaa
      601 ataaggattt actaaaccac caataatatt cccttctcct gaattatact gtgttggaag
      661 agcagattga gtcacactca tgtaatagct aaaggataaa aaatctacgg tataattttt
      721 taataactct gcatcttcag ctgcaaactc tatgttaatg tcatgttcct taaaatatct
      781 ttttgcataa ttcggataat aacctctaac atgcacatct gaaaatagat aatttagatt
      841 ctcatactca tgagtcgccc atacatcttt tggatttgga gtcattggat aagctggcat
      901 agctaatacc atacacccca ccttaaactc tgaattaatc tcacgagcaa tttttgtaac
      961 caaactcgag gcgactaatt catgatgtat agcttgatat aattcttgtt tcgaaagatt
     1021 ctccttaggt atatctattc ctccactagt aaacggtaat tccaaaacag agtttacttc
     1081 gttaaatgta agccaatatt taactttatc tttatacctt tttaaaactg ttcgagcaaa
     1141 tttttcataa aaatgaatca ttctcctatc aatccatcca tgatattttc ttgctaaata
     1201 taatggagtc tcatagtgtg aaagagttac aagtggttct atcccgtgag catgtagttc
     1261 atcaaataat tcatcataat atttcaaacc agcttcgtta ggttcttcct tatctccttt
     1321 tggaaaaatt ctactccatg caatagaagt acgaaaaaca ttaaagccca tttcagaaaa
     1381 caaggatata tcttccttat atttatgata aaaatcaata cctaacaact ttaagttatc
     1441 ttctgtagga ttttctgttg cttctcctaa tccacctttg ggtaacacat cctgaactga
     1501 taatccctta ccatcttcat tatatgctcc ctctacttga ttagctgcaa cagctccacc
     1561 ccaaagaaaa tcatctggaa aaatggtcat aactttcctc cattataata ttaccagtaa
     1621 ttccttagaa tgctcgattg tctgattatt aggtaatact aatacatcta gaaaatcatt
     1681 ggtattcgtt acaattactg gtgtaactgt ttcgtagcct ttagtcttga ttaaattcaa
     1741 gtccatttca aaaatcaact gatttttgaa aactctgtct ccttcttcta catgactaat
     1801 aaaaccttga ccttttagct caacagtatc taatccaata tgaattagta actcaacacc
     1861 ctcatcactc ttcaatccaa ttgcgtgctt agtcggaaaa atatttgtaa ttttcccatc
     1921 aaatggtgca taaaccttac cttcacttgg gataatcgct actccgtctc caattagttt
     1981 atctgaaaat gttttatcct ggacatcgct taacggaatg atttctcctg atataggaga
     2041 aaatatcatt tttttatttg aaactccaac ttcaacttct aaattgctag aactctcttc
     2101 ttcatcgatt ccaaatatat aagctaatac aaaggtaata acaaccgaaa tgaccgccac
     2161 aattaaagca tttacaatat ttgatggcac atcagaataa ataaattgag gcaacgctat
     2221 caaagatggg acagcaaata gatatgcttt aacactagta agacctgcaa ataatcccgc
     2281 taatccacca ccaatcatag ctgcataaag cggtttttta tattttaaag tcacaccata
     2341 taatgcaggt tcggtaatcc ctgcaagtaa ggctgagaaa cctgctgcaa aagcaatttg
     2401 ttttgtatta ttatttttac tctttaatgc aacagccatc gaagcagccc cttgagctaa
     2461 gtttgaccct aacattgctg gaagaattaa tacgtctgga gtagcaatag atgccgccaa
     2521 aaaaataggt gcaaaagccc aatgcattcc agtcataaca ataaatggca taatagcacc
     2581 aagaatagct aatgtaagcc atccagctac accatacatt tgcccaacta gatttgataa
     2641 tccttcacca acaattactc caataggtcc gactacaact aaggcaatac agcttgatac
     2701 taataatact agcgtaggtt gcaaaaaact cttagtaaca gctggtgtta atttagcaat
     2761 cattttttca atatatttca tcaaccaaac cataataaga attggaacga ctgacgaacc
     2821 ataactagct ggtgtcacag gtacaccaaa taaactaaga ggattccctg attgcaccat
     2881 ttgaacaaaa tttggatgga gaagtacacc tgctacagac atagctaatg tagatgttac
     2941 ttttaatttt tgtgatgcag aataagctaa taacagcggt aagaaataat atggagcatc
     3001 cccaaaaaat gtcaaaaaag caatagtctg agaatctgat tgcaatatac caagcattgg
     3061 taaaataatt accaagactt tcagcatacc tccccctaac attgctggaa tgattggagt
     3121 catggaacca gcgatatact caatgattct ttctaaaata ttccctttgt gcccttgaac
     3181 aactgaatcg gattcaaaat tgccaagttt aacgaattct ttataataat tagctacatc
     3241 attaccaagt ataatttgat attgtccatt ctttttcata atacctatta cacctggtat
     3301 cttcttcaca tcatcatcat tgactaaatt ttcatctttt aattctaatc ttaaacgtgt
     3361 tacacaatgg gtaactctat tgacattttt ttcacctcca attacatcga ggattttttg
     3421 taccgtatct ttataactca tggtattctc ctattctatt aatctaaatt ttttgttaag
     3481 cgacgaatat gagccatcaa ataaactaat tcactagaag tcagcaaata attgtactca
     3541 gtttgtataa acattgccac ctgttcacca cattcatatt ctctaggata tttatttttc
     3601 attaatgcta acaagtcttc atcatcatcg tcacaataag ttgtattttc aaccaagcga
     3661 tgggcaaata attttatatg agttatgaat ctataataat caatagaatc ttggttaaac
     3721 tcagtacaat agaaatcttg aatgattttc tcaattccca taattatttc agtgatttta
     3781 tacgactctt gaaaattatt ttctaaatta gcattaacaa aatgtagcgc tatgaatgca
     3841 gcttcgtcaa ttggaagttc aatacctaac tcttttttta ttatttgtaa agcccttttc
     3901 ccaagctcaa attcttcttt ataatatttc gagatttccc agcgtagggg attcgaaata
     3961 ataactcctt ctttataacg ttctatactc gaagaaatat gatccgttag atttatatag
     4021 ataatctcat caaaattatt acctaatgtt attttaccta gattaattat tttttcggtg
     4081 atgtacacca actccaaagg aacgttaata aacatctctg taaaacgggt catgttatct
     4141 ctatttttga gaaaaaaact tttctcaata tcaattggat ttactttatc tccaattttt
     4201 cttccaaaag ctattcccct tccaaaaaga agaatatcga tatctttttt actttgcgca
     4261 attacggcat tgtggtttag tattcgtttt atgatcataa aatttccctt ttaaaataaa
     4321 aggaacctac ttaaaaaaca tcaagaaact tcttctgatg tgattaaata ggttcctgct
     4381 cacttgtatt agtgataaca tccttttatt tcaattttta atggtgacat gaagcttaaa
     4441 taattaataa ctctgtaacc gtttttattt tatgatattt caatctattt gtcaagtact
     4501 tataaaaatt tttttatttt gtgtgattcg aatgtgataa tggcaacagt ctcactaaag
     4561 aaatgaaaat catacataga aatttttaaa aattttctct atcgtaaacc tgccactagt
     4621 tcagaaacta tactagctga ttccaaacgt aatatggtca tctcatctac ctcccctaat
     4681 aatggcattg caccatacca aacaatagtc ttattcacca aaagaatagg cgttactatt
     4741 tttgattgag taaaagacac tttaattttc tggctcttca actgtgaact acaccccaaa
     4801 agttagacag aaaaaatcta acttttgggg tgttttatta tgaaactaac ttatgatgat
     4861 aaagttcaga tctatgaact tagaaaacaa ggatatagct tagagaagct ttcaaataaa
     4921 tttgggataa acaattctaa tcttaggtac atgattaaat tgattgatcg ttacggaata
     4981 gagttcgtca aaaaagg
//
LOCUS       DAVHSO010000096         4862 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.097, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000096 DAVHSO010000000
VERSION     DAVHSO010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4862)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4862)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.097"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..1537
                     /locus_tag="VVR18_002120"
     rRNA            <1..1537
                     /locus_tag="VVR18_002120"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
     gene            1589..1661
                     /locus_tag="VVR18_002121"
     tRNA            1589..1661
                     /locus_tag="VVR18_002121"
                     /product="tRNA-Ala"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1622..1624,aa:Ala,seq:tgc)
     gene            1786..4687
                     /locus_tag="VVR18_002122"
     rRNA            1786..4687
                     /locus_tag="VVR18_002122"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
     gene            4764..>4862
                     /gene="rrf"
                     /locus_tag="VVR18_002123"
     rRNA            4764..>4862
                     /gene="rrf"
                     /locus_tag="VVR18_002123"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT         1344 a          999 c         1445 g         1074 t
ORIGIN      
        1 agtttgatcc tggctcagga cgaacgctgg cggcgtgcct aatacatgca agtagaacgc
       61 tgaaggagga gcttgcttct ctggatgagt tgcgaacggg tgagtaacgc gtaggtaacc
      121 tgcctggtag cgggggataa ctattggaaa cgatagctaa taccgcataa gagtggatgt
      181 tgcatgacat ttgcttaaaa ggtgcacttg catcactacc agatggacct gcgttgtatt
      241 agctagttgg tggggtaacg gctcaccaag gcgacgatac atagccgacc tgagagggtg
      301 atcggccaca ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat
      361 cttcggcaat ggacggaagt ctgaccgagc aacgccgcgt gagtgaagaa ggttttcgga
      421 tcgtaaagct ctgttgtaag agaagaacga gtgtgagagt ggaaagttca cactgtgacg
      481 gtatcttacc agaaagggac ggctaactac gtgccagcag ccgcggtaat acgtaggtcc
      541 cgagcgttgt ccggatttat tgggcgtaaa gcgagcgcag gcggttagat aagtctgaag
      601 ttaaaggctg tggcttaacc atagtaggct ttggaaactg tttaacttga gtgcaagagg
      661 ggagagtgga attccatgtg tagcggtgaa atgcgtagat atatggagga acaccggtgg
      721 cgaaagcggc tctctggctt gtaactgacg ctgaggctcg aaagcgtggg gagcaaacag
      781 gattagatac cctggtagtc cacgctgtaa acgatgagtg ctaggtgtta gaccctttcc
      841 ggggtttagt gccgtagcta acgcattaag cactccgcct ggggagtacg accgcaaggt
      901 tgaaactcaa aggaattgac gggggcccgc acaagcggtg gagcatgtgg tttaattcga
      961 agcaacgcga agaaccttac caggtcttga catccctctg accgctctag agatagagtt
     1021 ttccttcggg acagaggtga caggtggtgc atggttgtcg tcagctcgtg tcgtgagatg
     1081 ttgggttaag tcccgcaacg agcgcaaccc ctattgttag ttgccatcat ttagttgggc
     1141 actctagcga gactgccggt aataaaccgg aggaaggtgg ggatgacgtc aaatcatcat
     1201 gccccttatg acctgggcta cacacgtgct acaatggctg gtacaacgag tcgcaagccg
     1261 gtgacggcaa gctaatctct taaagccagt ctcagttcgg attgtaggct gcaactcgcc
     1321 tacatgaagt cggaatcgct agtaatcgcg gatcagcacg ccgcggtgaa tacgttcccg
     1381 ggccttgtac acaccgcccg tcacaccacg agagtttgta acacccgaag tcggtgaggt
     1441 aaccgtaagg agccagccgc ctaaggtggg atagatgatt ggggtgaagt cgtaacaagg
     1501 tagccgtatc ggaaggtgcg gctggatcac ctcctttcta aggataagga actgcgcatt
     1561 ggtcttgttt agtcttgaga ggtcttgtgg ggccttagct cagctgggag agcgcctgct
     1621 ttgcacgcag gaggtcagcg gttcgatccc gctaggctcc attggtgaga gatcaccaag
     1681 taatgcacat tgaaaattga atatctatat caaatagtaa caagaaaata aaccgaaaac
     1741 gctgtagtat taataagagt ttatgactga aaggtcagaa aataaggtta agttaataag
     1801 ggcgcacggt ggatgccttg gcactaggag ccgacgaagg acgtgacaaa cgacgatatg
     1861 ccttgggtag ctgtaagtaa gcgatgatcc agggatttcc gaatggggga acccaacagg
     1921 tagtacctgt tacccacatc tgttaaggat gtgaggagga agacgcagtg aactgaaaca
     1981 tctaagtagc tgcaggaaga gaaagcaaaa gcgattgcct tagtagcggc gagcgaaacg
     2041 gcaggagggc aaaccgaaga gtttactctt cggggttgta ggactgcaat gtggactcaa
     2101 agattataga agaatgattt gggaagatca gccaaagaga gtaatagcct cgtatttaaa
     2161 atagtctttg tacctagcag tatcctgagt acggcgggac acgtgaaatc ccgtcggaat
     2221 ctgggaggac catctcccaa ccctaaatac tccctagtga ccgatagtga accagtaccg
     2281 tgagggaaag gtgaaaagca ccccgggagg ggagtgaaat agaacctgaa accgtgtgcc
     2341 tacaacaagt tcgagcccgt taatgggtga gagcgtgcct tttgtagaat gaaccggcga
     2401 gttacgttat gatgcgaggt taagttgaag agacggagcc gtagggaaac cgagtctgaa
     2461 tagggcgcct tagtatcatg acgtagaccc gaaaccatgt gacctaccca tgagcaggtt
     2521 gaaggtgcgg taagacgcac tggaggaccg aaccagggca cgttgaaaag tgcttggatg
     2581 acttgtgggt agcggagaaa ttccaaacga acttggagat agctggttct ctccgaaata
     2641 gctttagggc tagcgtcgac attagagatt cttggaggta gagcactgtt tgggtgaggg
     2701 gtccatcccg gattaccaat ctcagataaa ctccgaatgc caatgaatta tggtcggcag
     2761 tcagactgcg agtgctaaga tccgtagtcg aaagggaaac agcccagacc accagctaag
     2821 gtcccaaaat aattgttaag tggaaaagga tgtggggttg cacagacaac taggatgtta
     2881 gcttagaagc agctattcat tcaaagagtg cgtaatagct cactagtcga gtgaccctgc
     2941 gccgaaaatg taccggggct aaaacaattt accgaagctg tggatacctt tataggtatg
     3001 gtaggagagc gttctatgtg tgatgaaggt ataccgtgag gagtgctgga acgcatagaa
     3061 gtgagaatgc cggtatgagt agcgaaagac aggtgagaat cctgtccacc gtaagactaa
     3121 ggtttccagg ggaaggctcg tccgccctgg gttagtcggg acctaaggag agaccgaaag
     3181 gtgtatccga tggacaacag gttgatattc ctgtactaga gtatgtagtg atggagggac
     3241 gcagtaggct aactaaagca gacgattgga agagtctgtc taagcagtga ggtgtgaatt
     3301 gagtcaaatg cttaattcta taacattgag ctgtgatggg gagcgaagtt tagtagcgaa
     3361 gttagtgacg tcacactgcc aagaaaagct tctagcgttt aaacatactc tacccgtacc
     3421 gcaaaccgac acaggtagtc gaggcgagta gcctcaggtg agcgagagaa ctctcgttaa
     3481 ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg tgctgacttt aagtcagccg
     3541 cagtgaatag gcccaagcaa ctgtttatca aaaacacagc tctctgctaa atcgtaagat
     3601 gatgtatagg gggtgacgcc tgcccggtgc tggaaggtta agaggagtgc ttagcgtaag
     3661 cgaaggtatg aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag
     3721 cgaaattcct tgtcgggtaa gttccgaccc gcacgaaagg cgtaatgatt tgggcactgt
     3781 ctcaacgaga gactcggtga aattttagta cctgtgaaga tgcaggttac ccgcgacagg
     3841 acggaaagac cccatggagc tttactgcag tttgatattg agtgtctgta ccacatgtac
     3901 aggataggta ggagtctaag agatcgggac gccagtttcg aaggagacgc tgttgggata
     3961 ctacccttgt gttatggcca ctctaaccca gataggtgat ccctatcgga gacagtgtct
     4021 gacgggcagt ttgactgggg cggtcgcctc ctaaaaggta acggaggcgc ccaaaggttc
     4081 cctcagaatg gttggaaatc attcgcagag tgtaaaggta taagggagct tgactgcgag
     4141 agctacaact cgagcaggga cgaaagtcgg gcttagtgat ccggtggttc cgtatggaag
     4201 ggccatcgct caacggataa aagctaccct ggggataaca ggcttatctc ccccaagagt
     4261 tcacatcgac ggggaggttt ggcacctcga tgtcggctcg tcgcatcctg gggctgtagt
     4321 cggtcccaag ggttgggctg ttcgcccatt aaagcggcac gcgagctggg ttcagaacgt
     4381 cgtgagacag ttcggtccct atccgtcgcg ggcgtaggaa atttgagagg atctgctcct
     4441 agtacgagag gaccagagtg gacttaccgc tggtgtacca gttgtcttgc caaaggcatc
     4501 gctgggtagc tatgtaggga agggataaac gctgaaagca tctaagtgtg aaacccacct
     4561 caagatgaga tttcccatga ttatatatca gtaagagccc tgagagatga tcaggtagat
     4621 aggttagaag tggaagtgtg gcgacacatg tagcggacta atactaatag ctcgaggact
     4681 tatccaaagt aactgagaat atgaaagcga acggttttct taaattgaat agatattcaa
     4741 ttttgagtag gtattactca gagttaagtg acgatagcct aggagataca cctgtaccca
     4801 tgccgaacac agaagttaag ccctagaacg ccggaagtag ttgggggttg ccccctgtga
     4861 ga
//
LOCUS       DAVHSO010000097         4696 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.098, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000097 DAVHSO010000000
VERSION     DAVHSO010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4696)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4696)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4696
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.098"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(98..1324)
                     /locus_tag="VVR18_002124"
     CDS             complement(98..1324)
                     /locus_tag="VVR18_002124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU6033572.1"
                     /translation="MKVFLQNRDFRQLTINQWISTLGDTIFYLAFLNYVADASFAPLA
                     ILLITISETLPQILQIFLGVLADFQHHRVLKYTVISFAKFLLYSIVSLSLSGQSFSLL
                     LVAFICLINLLSDTLSYFSGAMLTPIFIRIIGQDHLAEAIGFKQSTVSLVKTISNILG
                     GVLLGILSIQFISLLNALTFLIAFLGILFIKTDLLKVEKTINYQEGLSVKSFCQHLLQ
                     SSKLIWNMNKVLLVLFIISTSQAVINVTVPVSTLFLRNQPFLNLQTGQSLALLSTFEL
                     SALIVGSLVSGYLQHTISIKTALYASLVIQLLLLVGFATVRFDWILIFSTLDAFFAGV
                     LSPRLQELVFKQIPEESMGAVQSSIGAITVVLPSLFTIALVTIATSFGTLAVSFVLLL
                     FLLVAFVMLLNIRESI"
     gene            complement(1396..2061)
                     /locus_tag="VVR18_002125"
     CDS             complement(1396..2061)
                     /locus_tag="VVR18_002125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6033573.1"
                     /translation="MKKIISHRYFIIVFLLVIADQKFSVLVLRSDLVAGLSDFAYYLS
                     DMMLNFLVVLFALIAMIWSGKWQKINSRKFKGSYLFYSFLALLAFVAWNFVTFFLFPP
                     TRNEISYQHAAPTFTGATAFLMYFFYPVIAGPIFEDMIYRGLVMTALEKGKKWGLDVL
                     GSAVLFGVSHISNHGWVLTDFVFYMGGGLIFAVLFRMTKSIYWPIGLHIVYNGIGQLL
                     MLL"
     gene            complement(2073..2750)
                     /locus_tag="VVR18_002126"
     CDS             complement(2073..2750)
                     /locus_tag="VVR18_002126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU6033574.1"
                     /translation="MKKMKEVKFHLATGLLILTYYLIFNVTSDLDFMVALSDNMYYVF
                     QVLLVLILGTIATIAFVKSEHWKECGRFQFRWSYLGVFLLSFFLLFVWANLTTYIFPR
                     TQNGSTVVEVATSLTGISYFVTRILYTSIIAPVSEEVVCRGLLMTSLSKVKRYYLDVL
                     VSAAIFGAMHVLQYGWITTDFIKYFGMGLIFCMMFRYTRSIYWAIALHASWNSFLLIV
                     TLLVFGY"
     gene            complement(2772..3005)
                     /locus_tag="VVR18_002127"
     CDS             complement(2772..3005)
                     /locus_tag="VVR18_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033575.1"
                     /translation="MLNLQFAETMELTEAELQDVRGGNLVNSMGGGGRSGISGWGVPG
                     IYPGWGNQGMSPNRGAFDWTIDLADGLFGRRRR"
     gene            complement(3291..4154)
                     /locus_tag="VVR18_002128"
     CDS             complement(3291..4154)
                     /locus_tag="VVR18_002128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HEU6033576.1"
                     /translation="MIEKMELGEFYKELRLARKLKQSDVACAGLTASQLSKFELGQSM
                     LSADKLILAIQGINMNFDEFGHKLNNYQESPHMRIGRRVVDCFSHQDIAALEQLLEGV
                     DQEQMAQTYRRLNAIVIKNALHSLDKSYPLTEEDSEFLTTYLYAIESWTWFELYLFCN
                     TMPFLSNQDLIFLSTSLLEKSKEFKELVHNRWYMKSGYLNIISELMERKLFSYIPIFE
                     AELERMLRPYDVFEKVLWQFLKKMSIFLQTKGSNQKEIEHFIQSLQVLENPQLTALFE
                     LRLQQYKELID"
BASE COUNT         1643 a          926 c          809 g         1318 t
ORIGIN      
        1 tataacacat tcagaaaaga gaaaaaagtc tgttgatttt gaccatcata aaaagactgg
       61 caatccagtc tcaaacatat attatagaaa ttctccacta aatactttca cgaatattca
      121 gaagcataac aaaggcaact agaagaaata gcaataaaac aaagctaact gccagagttc
      181 caaagctagt agcaatggtt accaaagcta ttgtaaataa gctaggtaaa acaaccgtaa
      241 tggcaccgat agaggattga actgctccca ttgactcctc aggtatttgt ttaaaaacga
      301 gttcttgcaa tctaggagag agaacacctg cgaaaaaggc atccaaggta ctaaagatga
      361 gaatccagtc aaaacgaact gtggcaaatc ctactagaag aagcaactgg atgacaagtg
      421 aggcatagag agctgttttt atggaaatgg tatgttgcag atagccactt acaaggcttc
      481 cgacaatcag ggctgacagt tcaaaagtgg atagcaaggc aagagattga cctgtttgta
      541 aattcaaaaa gggttgattc ctcaaaaata gagtagagac aggaactgta acatttatca
      601 ctgcttgact agtagagata ataaacaaaa ccaagagcac cttattcata ttccatatca
      661 atttcgatga ttggagcaaa tgctggcaaa aggattttac agagagtcct tcttgatagt
      721 taatcgtttt ttctactttc aagaggtcag tttttatgaa aaggatacct aaaaatgcga
      781 ttaaaaaggt aagagcgttc agcaaggaaa tgaactggat ggagagaatc cctagcaaga
      841 ctcctcctag aatattactg attgttttca ctaaactaac agttgactgt ttaaatccaa
      901 tagcttctgc cagatggtct tgcccaataa ttctaatgaa aatcggagtg agcatggctc
      961 ctgaaaagta actcaatgtg tcagacaaga ggttaatcag acaaataaat gctactagca
     1021 acaaggagaa agactgccct gaaagtgata aagaaacgat agagtaaagc aaaaattttg
     1081 caaaactaat gactgtgtat ttcaagacac gatgatgttg aaaatctgcc aaaactccca
     1141 gaaagatttg taaaatttgg ggaagggttt ctgaaatcgt aatgagtaaa atcgccaaag
     1201 gggcaaaaga cgcatctgcc acataattca ggaaggccag ataaaaaatc gtatccccaa
     1261 gcgttgaaat ccactggttg atagttaatt gcctaaaatc tctattttga agaaatactt
     1321 tcattacaac tcctttttaa attcaaatgg gaatctttcc ccaagaatag accgcgatac
     1381 tactaacaac caaaattaca gtaacatcaa aagctgacca ataccattgt agactatatg
     1441 cagtccaata ggccaataaa ttgactttgt cattctaaat aagactgcaa atataagacc
     1501 tccacccata tagaagacaa agtctgtcaa gacccaaccg tgattactaa tgtgcgagac
     1561 cccaaataaa acagcggaac caagtacatc tagcccccat ttctttcctt tttccagagc
     1621 agtcatcact aatccacgat aaatcatgtc ttcaaaaatg ggacctgcaa tcacaggata
     1681 aaaaaaatac atcaaaaatg ccgtagctcc tgtaaaagta ggagcagcat gttgataaga
     1741 aatttcattt cgagtaggtg ggaaaagaaa aaaggtgaca aaattccaag caacaaaagc
     1801 aagcagagct aggaaggaat agaaaagata ggatccttta aactttctac tattgatttt
     1861 ctgccatttc cccgaccaaa tcatagcaat aagagcaaat aaaaccacaa gaaaattcaa
     1921 catcatatcc gacagataat aggcaaagtc agatagccca gcaacaaggt cgctgcgtaa
     1981 aactaaaaca ctgaacttct ggtcagcaat aactagtaga aaaactataa taaagtagcg
     2041 gtgtgagatt atctttttca tatatcacct ttctaatatc caaataccaa taaagtaaca
     2101 atgagtaaga agctattcca tgaagcatgc agagctatag cccaatagat ggatcgggtg
     2161 tagcgaaaca tcatacaaaa tatcaagccc attccaaaat actttatgaa atctgtcgtt
     2221 atccaaccat actgcaaaac atgcatagcg ccaaatatgg cagcggaaac aagaacatca
     2281 agatagtatc tcttaacttt agataaactt gtcatcaaaa gaccacgaca aacaacctct
     2341 tctgatacag gtgcgataat actagtataa agtattcgcg taacaaaata gctaattcct
     2401 gttaaactgg tggctacttc tacgactgta cttccattct gggtacgagg aaagatatag
     2461 gttgttagat ttgcccacac gaacaataag aaaaaagaaa gaaggaaaac acccaggtaa
     2521 gaccaacgaa actggaaacg accacactct ttccaatgtt cacttttgac aaaagcaatt
     2581 gtagctatag ttcccagaat aagtaccaat aaaacttgga acacatagta catattatca
     2641 gacaaagcaa ccataaaatc taagtctgat gtgacattaa aaatgaggta ataagtcaaa
     2701 atcaacaagc cagttgctag gtgaaatttc acttctttca ttttcttcat cctattatct
     2761 cctataagag cctatcttct acggcggcca aacaatccat ctgctaaatc tatagtccaa
     2821 tcaaaagctc cacgattagg actcatccct tgattgcccc aaccagggta aattcctggg
     2881 acgccccaac cagatatacc acttcttcca ccacctccca tagaatttac gaggttgcct
     2941 cctctaacat cttgcaactc agcttctgtc aattccattg tttctgcaaa ttgtaaattt
     3001 aacatctttt acactccttc aattatcttc atttgtaaac cacttctgcg acctaggatt
     3061 tgcttcaaat gttttacaag gacagtataa cacggaaatt ggcttatttt agaaaatcgc
     3121 atatttgata ttttttctta tagaaatttc agatttgcga ttttggtaga tttgattatt
     3181 tccctggtat aataaagtta ttactaatga ggagggaagt aatatgaaga aacaagtttt
     3241 aacattattg acgatcgttg ctgatattat tatctttttc ccatttctaa ctaatcgata
     3301 agctctttgt attgctgcaa acgcaattca aaaagggctg tcaattgtgg attttctaat
     3361 acttgcagag attggataaa gtgttcaatc tctttttgat tgcttccttt ggtttgaagg
     3421 aaaatgctca tcttctttaa aaactgccac aatacttttt caaaaacatc gtatggacgg
     3481 agcatgcgct ccagctcagc ttcaaagatt ggaatataag aaaatagctt gcgctccata
     3541 agttctgaga tgatattaag ataaccactt ttcatatacc atcgattgtg tactaactct
     3601 ttaaattcct tggatttttc gagtaaggag gttgataaaa agatcagatc ttgattgctc
     3661 aagaagggca tagtattgca aaaaagatag agttcaaacc aggtccaaga ctcaatagcg
     3721 tagaggtagg tagtcaaaaa ctcgctatcc tcctctgtta gcgggtagct tttatctaag
     3781 gaatggagtg catttttaat cacaatggca ttcaaacgac gataggtctg cgccatctgt
     3841 tcttgatcga ctccctccaa tagctgctct aaagcagcta tatcctgatg ggaaaagcaa
     3901 tccacaaccc ttctaccaat tcgcatatgt ggagattctt gatagttgtt gagtttgtgc
     3961 ccaaactcat caaaattcat attgatccct tggatggcta ggatcagctt gtctgcagac
     4021 agcatagact gtcctagttc aaacttggac aactgagagg ctgttagtcc agcacaagcc
     4081 acatctgact gcttgagctt tctcgccaag cgcaattcct tgtaaaattc ccccagttcc
     4141 attttttcaa tcatcctacc acctcctagc ttttgcatat tatatcatta tttgtgttca
     4201 tttgtcaaaa cattctgaca ctttggtgat tgaaaaagcc agccttaagc tgactctaaa
     4261 aggaccgagc cttgtacaat acagaactca atcctcgttc taaatagaat gtctaacttt
     4321 tttgggcagt acacgagctt ggggaacagc cactggaacg atgaggtgtg agctcaaaat
     4381 atcctccagt tatgtttttc ctaatagtat accggaagag tgaaaggatt ttataatgga
     4441 gcggttacaa agaacctact ttctattaaa cagtatacta tgaaaatgtg aaaatttaac
     4501 atttttttgt acaaatttta taaattattg cctctttaat atcaatagtt aatctcttat
     4561 ccagatcccc cttgtgtaaa ctttatcttt ataagcttca aggcccctat cccatctatt
     4621 tgcaacaatt agatcacttt gttttgtaaa tagttcaaaa ttcttttcaa aaattacgtt
     4681 atctatacta acgttt
//
LOCUS       DAVHSO010000098         4503 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.099, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000098 DAVHSO010000000
VERSION     DAVHSO010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4503)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4503)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4503
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.099"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..242
                     /locus_tag="VVR18_002129"
     CDS             <1..242
                     /locus_tag="VVR18_002129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033577.1"
                     /translation="LPTLTTPSVIIMDNARFHRMGKLELLCEEFGHKLLPLPPYSPEY
                     NPIEKTWAHIKKNLKKVLPSCNTFYEALLSCSCFN"
     gene            complement(235..408)
                     /locus_tag="VVR18_002130"
     CDS             complement(235..408)
                     /locus_tag="VVR18_002130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001022221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteinase"
                     /protein_id="HEU6033578.1"
                     /translation="MNIKKRVLSAGLTFASALLLAACGQSGSDTKTYSSTFGGNPTTF
                     NYLLDYYADNTVN"
     gene            complement(567..2174)
                     /locus_tag="VVR18_002131"
     CDS             complement(567..2174)
                     /locus_tag="VVR18_002131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HEU6033579.1"
                     /translation="MQEKWWHNAVVYQVYPKSFMDSNGDGVGDLPGITSKLDYLAKLG
                     ITAIWLSPVYDSPMDDNGYDIADYQAIATIFGTMEDMDQLIAEAKKRDIRIIMDLVVN
                     HTSDEHAWFVEACENTDSPERDYYIWRDEPNDLDSIFSGSAWEYDEKSGQYYLHFFSK
                     KQPDLNWENKKLRQKIYEMMNFWIDKGIGGFRMDVIDMIGKIPDEKVVNNGPMLHPYL
                     KEMNQATFGDKDLLTVGETWGATPEIAKLYSDPKGQELSMVFQFEHIGLQYQEGQPKW
                     HYQKELNIAKLKEIFNKWQTELGVEDGWNSLFWNNHDLPRIVSIWGNDQEYREKSAKA
                     FAILLHLMRGTPYIYQGEEIGMTNYPFETLDQVEDIESLNYAREALEKGVPIEEIMDS
                     IRVIGRDNARTPMQWDESKNAGFSTDQPWLAVNPNYEMINVQEALANPDSIFYTYQKL
                     VQIRKENSWLIRADFELLDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSV
                     LIENTLAQEVFEKQILVPWDAFCVELL"
     gene            2327..3811
                     /locus_tag="VVR18_002132"
     CDS             2327..3811
                     /locus_tag="VVR18_002132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HEU6033580.1"
                     /translation="MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHA
                     ARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKF
                     NELGIFVGSVVITQYAGQPAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPEGMG
                     KNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINGIKSGYAKFETFPVWNLPLHH
                     PVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMLERILGKSPYA
                     SPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMND
                     LGITPADRKVAVVARQKAEETGGPALAFELPNGEIVTGKNSELFGPTAAALINAIKKS
                     ADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEE
                     LGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK"
     gene            3906..4388
                     /locus_tag="VVR18_002133"
     CDS             3906..4388
                     /locus_tag="VVR18_002133"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HEU6033581.1"
                     /translation="MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLV
                     QPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAV
                     IKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
                     "
BASE COUNT         1316 a         1023 c          854 g         1310 t
ORIGIN      
        1 tcttaccaac attaaccaca ccatcggtta ttattatgga taatgcaaga ttccatagaa
       61 tggggaagtt agaactttta tgcgaagagt ttgggcataa acttttacct cttcctccct
      121 actcacctga gtacaatcct attgagaaaa catgggctca tatcaaaaag aacctcaaaa
      181 aggtattacc aagttgcaat accttttacg aagctctttt gtcttgttct tgtttcaatt
      241 gactgtatta tcagcgtaat agtctaatag atagttaaat gtagttggat ttccaccaaa
      301 ggttgatgag taagtttttg tatctgaacc tgattggccg caagcagcta aaagcaaagc
      361 agatgcaaaa gtcaggcctg cactaaggac acgcttcttt atgttcatct tctttctcct
      421 taatagtggg aatttgtaaa gttaattgaa tttcgagaat gaaagtttat aaaccttggt
      481 tataaaaaac aaaggatttc cgccttttat acagtcctcc cttgttttta tatgatttca
      541 attttaaatt tttctgcaaa aaatatttat agtaattcca cacagaaagc atcccatgga
      601 actaagattt gtttttcaaa gacttcttga gctagggtgt tttcaatcaa gacagatttg
      661 acttttcctt ctactgtcaa gtcttgctct tcattggaca agttagccac aactaggaag
      721 cgacggtcgc catccttacg tatataagca aagaccttat cagccgtatc aagcaattca
      781 aagtcagctc gaattaacca gctattctcc ttgcgaattt ggaccagttt ctgataggta
      841 tagaaaatag aatctggatt tgccagcgct tcttggacgt tgatcatctc gtaatttgga
      901 ttaactgcca accaaggttg atctgttgaa aaaccagcgt ttttgctctc gtcccattgc
      961 ataggggtac gggcattgtc acgtccaata acacggatac tgtccatgat ttcttcaatc
     1021 ggaacacctt tttcaagagc ctcacgcgca tagttgaggg attcaatatc ttctacttga
     1081 tctagtgttt caaacggata gttggtcatc ccaatctcct caccttggta gatataagga
     1141 gttcctctca tgagatgaag taagattgca aaggctttgg cagatttttc gcggtattct
     1201 tggtcatttc cccagattga gacaatacga gggaggtcat ggttgttcca gaagagggaa
     1261 ttccagccgt cctcaactcc taactctgtc tgccatttgt tgaagatttc ttttaactta
     1321 gcgatattca gctctttttg atagtgccat ttaggctgac cttcctgata ctgaagaccg
     1381 atatgttcaa actggaagac catagacaat tcttgcccct ttggatcaga gtagagcttg
     1441 gcaatctctg gcgttgctcc ccaagtctcc cctactgtca agagatcctt atctccaaag
     1501 gtcgcctgat tcatttcctt gagataggga tggagcatag gaccattatt gactaccttc
     1561 tcgtcaggaa ttttgccaat catgtcaata acatccatac ggaaaccacc aataccttta
     1621 tcaatccaga agttcatcat ctcataaatt ttctggcgaa gttttttatt ttcccagttg
     1681 agatccggct gtttcttgct gaaaaagtgg agatagtatt gacctgactt ttcatcgtat
     1741 tcccaagcag acccactaaa gatagaatct aggtcattgg gttcatcgcg ccagatatag
     1801 tagtctcgct cagggctgtc agtattttca caagcttcga caaaccaagc atgttcatct
     1861 gaggtatgat taaccaccaa gtccatgatg atacgaatgt cacgcttctt agcttccgca
     1921 atcagttgat ccatatcctc catggttcca aaaatcgttg caatcgcttg ataatcagca
     1981 atatcgtagc cattatcatc catagggctg tcataaacgg gagaaagcca aatcgctgtg
     2041 attcctagct tagctagata gtccaactta ctggtaatac ctggcaaatc accaactcca
     2101 tctccattac tatccataaa actctttgga tagacttgat agactacggc attatgccac
     2161 catttttctt gcatctgttt acctcattat tttaataatc tatagtatat gatagcactt
     2221 tttaaaattt tgtgcaagcg tttgcttaat ctttttaatt tcttttttag ctccgtagtt
     2281 tcctaacttc caatttttta ttataataga gtccagaggt aaaaaaatga aaaaacaagc
     2341 ttttagttct gaacagtatt tgaatttaca acgcgaccat attttggagc gcattaacca
     2401 atttgacggc aagctctact tagagtttgg cggtaaaatg ttagaagatt tccacgctgc
     2461 tcgtgtcctt cctggttatg aacctgacaa caaaatcaag ctcttgcaag aattgaaaga
     2521 gcaggttgag gttgtgattg ccattaatgc tagcaacatt gaacattcca aagcacgtgg
     2581 cgacttaggc atttcttatg accaagaagt tcttcgtttg attgacaaat tcaatgaatt
     2641 agggattttt gttggttccg ttgtcattac acaatacgct ggccaacccg ctgcagatgc
     2701 cttccgcaac caacttgaga aaaacggaat tgattcttat cttcattatc caatcaaagg
     2761 atatcctacg gatatggatc acatcatttc cccagaaggc atgggcaaaa acgactacat
     2821 caaaaccagt cgcaacttga ttgtcgtaac cgctcctgga cccggttctg gaaaattggc
     2881 aacgtgtatg tccaatatgt accacgacca aatcaatggc atcaaatctg gctacgctaa
     2941 atttgaaacc ttccctgttt ggaatcttcc ccttcatcat ccagttaact tggcttatga
     3001 agctgccaca gctgaccttg atgatgtcaa catgattgac cccttccatc ttcaaaccta
     3061 tggagaaacc actgtcaact acaaccgtga tatcgaaatc ttcccagtgc tcaaacgcat
     3121 gttggaacgt attctcggaa aatcaccata cgcttcaccg acagatatgg gtgtcaacat
     3181 ggttggtttc gctattacag atgacgaggc tgctgtcgaa gcttctaaac aagaaatcat
     3241 ccgccgttac tatcaaacag ttcttgactt caaagctgaa aaagttggcg aagctgccgt
     3301 caagaaaatt gagttgctca tgaacgacct cggtatcaca cctgcagatc gtaaggttgc
     3361 tgtcgttgcg cgccaaaaag cagaagaaac tggtggacca gccctagcct ttgaattgcc
     3421 aaatggggaa atcgtcactg gtaagaactc agaactcttt gggcctacag ccgctgcctt
     3481 gatcaacgcc atcaaaaaat cagctgacat cgctaaagaa gtaaaactaa tcgagcctga
     3541 agttgttaag ccaatccaag gtcttaaaat cgatcatctc ggtagccgca atccacgcct
     3601 tcattcaaat gaaatcctga ttgcacttgc tatcacagct acagaaaatc ctgatgctgc
     3661 ccgcgctatg gaagaactcg gcaacctcaa aggaagcgaa gcccactcaa ccatcatctt
     3721 gactgatgaa gacaagaatg tccttcgtaa actgggtatc aacgtaacct ttgacccata
     3781 ctaccaatac gaccgcttat atcgtaagta aagatttcaa cctctccagc ctcggagagg
     3841 ttttctctct gtctcaggag caacctttat gatataatga gagaagaaaa ctgaaaggat
     3901 ttaccatgtc aaaagaagtt attgtcgaaa gttttgaact tgaccacacc attgtcaaag
     3961 caccctatgt tcgcttgatt ggggaagaaa caggaccaaa aggagacatc atctccaatt
     4021 atgatattcg cttggtgcaa ccaaacgaag actctatccc tactgccggt cttcacacta
     4081 tcgagcacct cttagccaaa ctcatccgta cccgcattga cggcatgatt gactgttcac
     4141 catttggttg ccgcacaggc ttccacatga ttatgtgggg acgtcacacc agtgctaaaa
     4201 tcgcagctgt tatcaaggat tcgctcaagg aaatcgctga aactactact tgggaagatg
     4261 tcccagggac aaccatcgaa tcttgcggaa actacaagga ccacagcctc ttctctgcta
     4321 aagaatgggc aaaactcatc ttggaacaag ggatttcaga tgatgccttt gaacgtcatg
     4381 tgatttaaaa tcgagtaggg gataatctct agcccctctc acaccaccgt acgtgccgtt
     4441 cggcatacgg cggttcaact aacttttaac gcatgtcgtt caaggtaata atccaaacac
     4501 gaa
//
LOCUS       DAVHSO010000099         4446 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.100, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000099 DAVHSO010000000
VERSION     DAVHSO010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4446)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4446)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4446
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.100"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(99..1933)
                     /locus_tag="VVR18_002134"
                     /pseudo
     CDS             complement(99..1933)
                     /locus_tag="VVR18_002134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261796.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(1920..2285)
                     /locus_tag="VVR18_002135"
     CDS             complement(1920..2285)
                     /locus_tag="VVR18_002135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="HEU6033582.1"
                     /translation="MVYRYRTNLKKVFLTDSELHQLNERIDKRHCQNFSVYTRKVLLN
                     PNMAFVTINTDTYEQLVFELRRIGNNINQIVRAINQSHLISQDQLQELSKGISELITG
                     VEKDFQVEVNRLKEFYGSH"
     gene            complement(2295..2654)
                     /locus_tag="VVR18_002136"
     CDS             complement(2295..2654)
                     /locus_tag="VVR18_002136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033583.1"
                     /translation="MGQEIKLIRKQFRITRQEEKQIKEMMREQKVDSFSEFLRQNLLK
                     KNYQDRIFESWFSLWQSQKFEQISRDVYEVLVVARENHQVTQEHVSILLTCVQELIAE
                     VNQVQSLSRGFREKYMR"
     gene            complement(3486..3938)
                     /locus_tag="VVR18_002137"
     CDS             complement(3486..3938)
                     /locus_tag="VVR18_002137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033584.1"
                     /translation="MEFNINSKESSQQLDILYKEVGVLSLGQKVVAMLNFLLAYSDYS
                     KDFRPLIIDQPEDNLDNRYIYRHLVQQFRDVKAQRQIILATHNATIVTNSMTDQVVIM
                     ESDGVNGWIESQGYVSEKYIKNHIINQLEGGKNSFKHKMSIYETALSE"
     gene            complement(3866..4446)
                     /locus_tag="VVR18_002138"
                     /pseudo
     CDS             complement(3866..4446)
                     /locus_tag="VVR18_002138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001822207.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT         1297 a          870 c          634 g         1645 t
ORIGIN      
        1 tgtgcttaaa ccatatgagt gtgctccatg tattgcagtt ccttaaatca agcataatcc
       61 agcatttcta gctttatccc tcctctaaaa tttgtccatt acgaaaacat cttttccata
      121 tttaacgtgc ttccaaaaat ttctaatctt attgctcttt tctcaaactc ataaagataa
      181 tagtctaagt tttcttgcaa tactcttatt tcttcgttca cattttctaa tgaagttgat
      241 tctgttaagt tcagttttga aaagtcatac ctggctaatt ttctaccgat ctcatcttca
      301 ctcttcagat tgataagcac ttccgccatt ttgtttaagg tggcgatttt ttcttgggtt
      361 tcttctagct tcatatcaat ctatgcaatt tctaacacaa gctcatcttt gatttcttgg
      421 tattgtttgt tcgtgttaga tagttcaatc ataagattaa tttcagaaat cttctcttga
      481 agacttttta aagttggtcg tctatatggg agtttttggc tatcgttgct caattgtctg
      541 attaaggtcc tacccttgat gaaacaatta ttatccctgt tttctttatt atagacaaag
      601 taagaagacg tttctcgaat gtagacttta tattttttat gattttattc ttccataata
      661 tccaattgat agttgggaat gaaaataaga ccgctctgtt tgacaccgaa agacaccttg
      721 atatagacgc ccttatcaac tagcttctct atttggttct ctgcaagttc cacttcaaat
      781 tcacgaacag catctctctt ttccttaaat gtctcaaagg cttcctcgat ttcttcagcg
      841 gagactttct ccttatgctg ctcctctcga aaagtctgaa aatcttcctg aagattttct
      901 aatgcttgaa tatctctaac ttctctatct tcaaaataac gattaaaaat tgaacatcgt
      961 acaatttctt ctcacttatt tttttatgac tcaggcttat ctttttgcca tcttcttcta
     1021 gggtaaacat cacatttttc tgttttaact cgatggttag attcaactct ttagctttta
     1081 catgcaattc ttctaatgaa taaacagact ttagtaaaaa ttttaaacga ctttcaatct
     1141 cttgtttggc aaaatatgtt ttaaaaaagt cttcatcata taaatctcgt ttactaagtt
     1201 ggcgacctcg aattggtttt atcatcgttc tatctgtcat caaaaaacgg ctatgctttt
     1261 gactaaaatc aatctgaaca tgcaactgct ttgctttctc taaaaaatca tcaaacgatt
     1321 tagattgctg aagcaaaaaa taaagacgtt gtttcaattc aaatttatga ctagattcct
     1381 tatatttttt ataatctcga taggaataac gtttctcaat aatttttgca ccagccattt
     1441 tagaaatacg gtctgaaatc atacggaggt ttcgttccaa ggcatagttc catatcaact
     1501 ttttatctga attgcggtca atagcgttga ttaggatgtg attatgaaca tgatctttgt
     1561 ctgtgtgagt tgctacgata aacttaaaac gacctcctgt caattccatc atggtctcat
     1621 aaccaatgcg gttaatttct tcaggtgtca gattatcttc aggagaaaat gattggatga
     1681 gatgatgggc atgaatagtt tgttggtgtc tttcttgtcg gtcatttctg gattcgtaca
     1741 acttgtcatt attgctgaag ttgacattgt atatctctac catttctgca tgactaggga
     1801 agtccaagta attgctcatg ccaaaatcag ataccaattt caaattgtcc gttttatcag
     1861 ggttgagaat atacttaatt aaacgcctac gatatttttt tccgtgcgtc gcaaaatgtt
     1921 tagtgactac cataaaactc cttcagtcta ttcacttcaa cttgaaaatc tttctctact
     1981 ccagtaatta actcactaat tcccttactc aattcttgta attggtcctg agaaatcaga
     2041 tggctctgat tgatagcgcg cacaatttga ttaatattat ttccaatccg tctcaattca
     2101 aatactaact gttcataggt atccgtgtta attgtgacaa aagccatatt aggattaagt
     2161 aacacttttc tggtgtagac tgagaaattt tgacagtgcc tcttgtcgat tcgctcattc
     2221 aattgatgta attctgaatc tgttagaaat acttttttga gattggtacg ataacgataa
     2281 accatagtag cctcctatct catgtatttt tcacgaaacc cacgactgag tgactgtact
     2341 tgattgactt ccgcaatcaa ttcttgaacg caagtcaata agattgagac gtgctcttga
     2401 gtcacttgat gattttctct tgcgacaacc agaacttcat acacatctcg actaatctgt
     2461 tcaaactttt gagactgcca aagggagaac caactttcaa aaattctatc ctgataattc
     2521 tttttcaata aattttgacg aagaaattct gagaaactat ccactttttg ttccctcatc
     2581 atttctttta tctgtttttc ttcttgtctc gtgattctaa attgcttacg gattaactta
     2641 atttcttgtc ccatcttacc attctttcaa cattatactt gtctgacaat gtaaggctgc
     2701 ctcacattgt cagtacgatt cctaaagacc tcagtctctc cttgttcggt ctttgcgagc
     2761 tcagatattg tgtccacaat atcccaaaaa tcatatcgcc agcctatcaa aaccttctag
     2821 ttttgatagc caacgataag ataacttggt ggctccgccc ccaaaccccc aggtaaaatt
     2881 cttagttgga tttttaaaag ttgagaaaag tatagcagaa gaaatttggg gaagttatca
     2941 caaatcaagt agggactaat ctctaacact actgcatgta tcgtcctata tttatgatca
     3001 gctcccatca tttacatttt caggtcactg tcttttcata ccaggaatta gaattgacaa
     3061 atttaattag agaggtattc atttaattgt tcacttcttc gctccatttc cattacagaa
     3121 atttcttcaa tactatgtgt tcagctgact cccatgattc gttgtactac gtcctaaacg
     3181 ctcacggaat aagccgtaca tctttcctag tttactctcg taattcacgt atataggtta
     3241 cgacacctat ttggatttta gagttcctca tccgctatat atggcttcaa gtcacgattc
     3301 tgtttgtaga gccttgattt cgctaattcc ttcctatccc ccctacctca cgatattcag
     3361 gattaggagt cgctattggt ttcatctgca gcaaatatcc acagaggact tggacctcag
     3421 atgtacacta tgcctgtcgg acaaagaaaa aagtaggcta aatttctagc ctactttttc
     3481 tgactctact ctgataaagc cgtctcatat atagacattt tatgcttgaa agaatttttt
     3541 cctccctcta attgattgat gatatgattt tttatatatt tttcactaac atatccctgt
     3601 gattcaatcc atccgttaac tccatctgac tccataataa caacttgatc tgtcatagaa
     3661 tttgttacaa ttgtagcatt atgtgttgct aaaataattt gacgttgagc tttcacatct
     3721 ctaaactgct gaactaaatg cctgtaaata taacgattgt ctaggttgtc ttcaggctga
     3781 tcaataatca atggtctgaa gtctttagaa tagtcactat atgctaataa aaaattaagc
     3841 atggctacaa ctttttgtcc caaacttaat acaccaactt ctttatagag aatatcaagt
     3901 tgttgcgaag attctttcga gttaatatta aactccaaaa atcgtgtatt ttctttagaa
     3961 aaaatttttc gtttatatgc acctaataag tgagaacctt ttttcaaaat gtcataacta
     4021 ttgaaatgag caatatagtt aactattttt tgattattga aatccttcat tatagtcagt
     4081 aaatgttgat aacttccatc tttctcactt ataatatttt cacttaacca ttgattaacc
     4141 catgattctt gttcataatc atatatacat acaatatgca atttatctgc tgcactaatt
     4201 tctactccat gtaaaatatg aggatgtata tcataaatcg gataattttt cattatgatt
     4261 gagactgcca tttgtaactt tttaatacct ttggtagtat tatgatcagt tactacaact
     4321 atttctattc cattttttat gattgcctct gctaacataa gaaaactaat atattctttt
     4381 gaactagaaa aaacaacctt atcaaaatta ctaaaaaaaa ttgtcttatc aacttttatt
     4441 ttctta
//
LOCUS       DAVHSO010000100         4165 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.101, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000100 DAVHSO010000000
VERSION     DAVHSO010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4165)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4165)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4165
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.101"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            214..1659
                     /gene="cps4A"
                     /locus_tag="VVR18_002139"
     CDS             214..1659
                     /gene="cps4A"
                     /locus_tag="VVR18_002139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4A"
                     /protein_id="HEU6033585.1"
                     /translation="MSRHFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSY
                     AMPDSNLYVLEIDDSSLAVVKAAIQDVMEGR"
     gene            1661..2392
                     /locus_tag="VVR18_002140"
     CDS             1661..2392
                     /locus_tag="VVR18_002140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine protein phosphatase"
                     /protein_id="HEU6033586.1"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRIIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QINSYHVLKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     gene            2401..3093
                     /gene="cpsC"
                     /locus_tag="VVR18_002141"
     CDS             2401..3093
                     /gene="cpsC"
                     /locus_tag="VVR18_002141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000664160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     CpsC"
                     /protein_id="HEU6033587.1"
                     /translation="MEKQNTLEIDVLQLFRSLWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVSRDQGEKSGLTNQDLQAGSYLTKDYREIILSQDVLEEVVSDLKLD
                     LTPKGLANKIKVAVPVDTRIVSISVNDQVPEGASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPAISPSSPNIKLNTLIGFLVGLIVINVTVLLLELLDTRVKRPEDIEDALQMT
                     LLGVVPNLDKLK"
     gene            3103..3777
                     /locus_tag="VVR18_002142"
     CDS             3103..3777
                     /locus_tag="VVR18_002142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase"
                     /protein_id="HEU6033588.1"
                     /translation="MPTLEIVQKKLEFIKKTEEYYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSINIAWSFARAGYKTLLIDGDIRNSVMSGVFKSREKITGLTEFLSGTTDL
                     SHGLCDTNIENLFVVQSGAVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGVVI
                     DSAIITQKCDASILVTATGEVNKRDVPKAKQQLEQTGKLFLGVVLNKFNVQHEKYGSY
                     GNYGKR"
BASE COUNT         1349 a          660 c          859 g         1297 t
ORIGIN      
        1 tgaaactaga gtagtacacc tctgcttcta aaaaattttt agaaatcgat ttaactgtcc
       61 tgatcgattt gtcatgttct tatttcattt tactatattt ttgtttcgcg ggaagtctac
      121 taagatactt aaagatgcag atagtaaaaa aatgtagaca ttaccgtaaa aaagtgatat
      181 aatcgtatga tgttcaaggt ataggtgtta atcatgagta gacattttaa aaaatcacgt
      241 tcacagaaag tgaagcgaag tgttaatatc gttttgctga ctatttattt attgttagtt
      301 tgttttttat tgttcttaat ctttaagtac aatatccttg cttttagata tcttaaccta
      361 gtggtaactg cgttagtcct actagttgcc ttggtagggc tactcttgat tatctataaa
      421 aaagctgaaa agtttactat ttttctgttg gtgttctcta tccttgtcag ctctgtgtcg
      481 ctctttgcag tacagcagtt tgttggactg accaatcgtt taaatgcgac ttctaattac
      541 tcagaatatt caatcagtgt cgctgtttta gcagatagtg atatcgaaaa tgttacgcaa
      601 ctgacgagtg tgacagcacc gactgggact gataatgaaa atattcaaaa actactagct
      661 gatattaagt caagtcagaa taccgatttg acggtcgacc agagttcgtc ttacttggca
      721 gcttacaaga gtttgattgc aggggagact aaggccattg tcttaaatag tgtctttgaa
      781 aatatcatcg agtcagagta tccagactac gcatcgaaga taaaaaagat ttataccaag
      841 ggattcacta aaaaagtaga agctcctaag acgtctaaga atcagtcttt caatatctat
      901 gttagtggaa ttgacaccta tggccctatt agttcggtgt cgcgatcaga tgtcaatatc
      961 ctgatgactg tcaatcgaga taccaagaaa atcctcttga ccacaacgcc acgtgatgcc
     1021 tatgtaccaa tcgcagatgg tggaaataat caaaaagata aattaaccca tgcgggcatt
     1081 tatggagttg attcgtccat tcacacctta gaaaatctct atggagtgga tatcaattac
     1141 tatgtgcgat tgaacttcac ttctttcttg aaaatgattg acttattggg aggggtagat
     1201 gttcataatg atcaagagtt ttcagctcta catgggaagt tccatttccc agtagggaat
     1261 gtccatctag actctgagca ggctctaggt tttgtacgtg aacgctactc actagccgat
     1321 ggagaccgtg accgtggtcg caaccaacaa aaggtgattg tggctatcct tcaaaaatta
     1381 acgtcaaccg aagcactgaa aaattatagt acgatcatta atagcttgca agattctatc
     1441 caaacaaata tgccacttga gactatgata aatttggtca atgctcagtt agaaagtgga
     1501 gggaattata aagtaaattc tcaagattta aaagggacag gtcggacgga tcttccttct
     1561 tatgcaatgc cagacagtaa cctctatgtg ttggaaatag atgatagtag tttagctgta
     1621 gttaaagcag ctatacagga tgtgatggag ggtagatgaa atgatagaca tccattcgca
     1681 tatcgttttt gatgtagatg acggtcccaa gtcaagagag gaaagcaagg ctctcttggc
     1741 agaatcctac aggcaagggg tacgaatcat tgtctctacc tctcaccgtc gcaagggcat
     1801 gtttgaaact ccggaagaga agatagcaga aaactttctt caggttcggg aaatagctaa
     1861 ggaagtggcg agtgacttgg tcattgctta tggcgcagag atatactata ctctggatgc
     1921 tctagaaaag ctagaaaaaa aagaaattcc tacccttaat gatagtcgtt atgctttgat
     1981 tgagtttagc atgcatactt cctatcgtca gattcatacg ggattgagca atattttgat
     2041 gttgggaatc acgccagtaa ttgctcatat tgaacggtat gatgctttag agaataacga
     2101 aaaacgtgtt cgtgaactga ttgatatggg atgctatact cagataaata gttatcatgt
     2161 tttaaaacct aagttctttg gtgaaaaata taaattcatg aaaaagagag ctcggtattt
     2221 tttggaacgt gatttagttc atgtagttgc aagtgacatg cacaatttag acagtagacc
     2281 tccatatatg caacaggcat atgatatcat tgctaagaaa tatggagcga aaaaagcgaa
     2341 agaacttttt gtagataatc ccagaaaaat tataatggat caattaattt aggagaaaat
     2401 atggagaaac aaaacacttt ggaaatcgat gtattgcaac tattcagatc tttatggaaa
     2461 agaaagttgg tcattttatt agtggcaatt ataacttctt cagttgcttt tgcctacagt
     2521 acttttgtta tcaaacctga gtttactagt acgactcgga tttatgtagt tagccgtgat
     2581 cagggagaga agtctggttt aaccaatcaa gacttgcagg caggatcgta cttgactaaa
     2641 gactatcgtg aaattatcct atcgcaggat gttttggagg aagttgtttc tgatttgaaa
     2701 ctagatttga cgccaaaagg tttggctaat aaaattaaag tggcagtacc agttgatacc
     2761 cgtatcgtgt ctatttcggt taatgatcaa gttcctgaag gggcaagccg tatcgctaac
     2821 tctttgagag aagtggcggc tcaaaaaatt atcagtatta ctcgtgtttc tgatgtgaca
     2881 acactggagg aggcaagacc agcgatatca ccgtcttcgc caaatattaa actcaataca
     2941 ctaattggtt ttttggtagg attgattgtc ataaatgtta cagttcttct tcttgaactt
     3001 ttggacacac gagtgaaacg tccggaagat atcgaagatg cactacagat gacacttttg
     3061 ggggttgtac caaacttgga taagttgaaa taggagagag agatgccgac attagaaata
     3121 gtacaaaaaa aactggagtt cattaagaag acagaggaat attacaatgc cttgtgtaca
     3181 aacatacagt tgagcggaga taaactaaaa gtgatttccg ttacttctgt taaccctgga
     3241 gaagggaaaa caactacttc tataaatata gcatggtctt ttgcgcgtgc aggatataaa
     3301 actcttttga tagatggcga tatccgaaat tcggtgatgt caggagtttt taaatctcgt
     3361 gaaaaaatta caggcttaac agaattttta tctggtacaa ctgatttatc tcacggttta
     3421 tgtgatacaa atattgaaaa tttatttgta gttcaatcgg gagctgtatc accaaaccct
     3481 acagccttgt tacaaagtaa aaattttaat gatatgattg aaaccttgcg taaatatttt
     3541 gattatatca ttgttgatac agcacctatt ggagttgtta ttgattcggc aattatcact
     3601 caaaagtgtg atgcgtctat cttggtaacg gcaacgggtg aggtgaataa acgtgatgtc
     3661 ccaaaagcga aacaacaatt agaacaaaca gggaaactat ttttaggtgt cgttctcaat
     3721 aaatttaatg ttcaacatga aaaatatggt tcttacggta attatggtaa aagataaaat
     3781 gaatatagta tggaaggggc tacaatataa ctctggcatt ctgaactgca ccccaaaagt
     3841 tagacagaaa aaatctaact tttgggggtc agtacattct tacagggtac acttgttagt
     3901 ttattagctt agatactgat tgcaatttca gaaaccgata ttttttcaaa taaatattcg
     3961 gtctgtttgg aagtgcaatc gaactgaact ttccaatgct ttattgggca tcatatatta
     4021 ccgaaacaaa taaattttgt tatattggat gatgttgtta tgttattgta aaaatattgt
     4081 gtgaccaaat atattgagtc tttgtggtct aataggctga tatatttaat ttgataaata
     4141 aaaataagat gaagtttgaa tttag
//
LOCUS       DAVHSO010000101         4034 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.102, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000101 DAVHSO010000000
VERSION     DAVHSO010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4034)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4034)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4034
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.102"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            38..205
                     /locus_tag="VVR18_002143"
     CDS             38..205
                     /locus_tag="VVR18_002143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002319681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich KTR domain-containing protein"
                     /protein_id="HEU6033589.1"
                     /translation="MCPVCGNKTRLKIREDTELKKFPLYCPKCRQENLIEIKQFKVTV
                     ITEPDAKTQSR"
     gene            complement(265..618)
                     /locus_tag="VVR18_002144"
     CDS             complement(265..618)
                     /locus_tag="VVR18_002144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033590.1"
                     /translation="MRKKEDKYDFRAFGLAIKEARLKRGLTREQVGALIEIDPRYLTN
                     IENKGQHPSIQVLYDLVSLLHVSVDEFFLPANNLVKSTRRLQIEKYMDSFTDKELSLM
                     ESLASGINEARNIED"
     gene            1123..1545
                     /locus_tag="VVR18_002145"
     CDS             1123..1545
                     /locus_tag="VVR18_002145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006733729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU6033591.1"
                     /translation="MKPSSFQTTIENQFDYICKRAMEDERKNYMLYLSRIAKREVSFS
                     DVGDYLVSQFATTDNYSTDFQIFTLNGLSVGVENDLLSEALRELPDKKREILLLFYFM
                     DMSDSEIADLLKLNRSTVYRHRTSGLALIKKFMEEFEE"
     gene            1542..1772
                     /locus_tag="VVR18_002146"
     CDS             1542..1772
                     /locus_tag="VVR18_002146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002411750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033592.1"
                     /translation="MKTQYPMIPFPLIVKATDGDTEAINQILHHYRGYITKRSLRLMK
                     DEYGNQSMVVDEVLRGRMETRLITKILSFEIK"
     gene            2233..2436
                     /locus_tag="VVR18_002147"
     CDS             2233..2436
                     /locus_tag="VVR18_002147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006730246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HEU6033593.1"
                     /translation="MKQTDIPIWERYTLTIEEASKYFRIGENKLRRLAEENKNANWLI
                     MNGNRIQIKRKQFEKIIDTLDAI"
     gene            2518..3735
                     /locus_tag="VVR18_002148"
     CDS             2518..3735
                     /locus_tag="VVR18_002148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020220015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEU6033594.1"
                     /translation="MSEKRRDNKGRILKTGESQRKDGRYLYKYIDSFGEPQFVYSWKL
                     VATDRVPAGKRDCISLREKIAELQKDIHDGIDVVGKKMTLCQLYAKQNAQRPKVRKNT
                     ETGRKYLMDILKKDKLGVRSIDSIKPSDAKEWAIRMSENGYAYQTINNYKRSLKASFY
                     IAIQDDCVRKNPFDFQLKAVLDDDTVPKTVLTEEQEEKLLAFAKADKTYSKNYDEILI
                     LLKTGLRISEFGGLTLPDLDFENRLVNIDHQLLRDTEIGYYIETPKTKSGERQVPMVE
                     EAYQAFKRVLANRKNDKRVEIDGYSDFLFLNRKNYPKVASDYNGMMKGLVKKYNKYNE
                     DKLPHITPHSLRHTFCTNYANAGMNPKALQYIMGHANIAMTLNYYAHATFDSAMAEMK
                     RLNKEKQQERLVA"
BASE COUNT         1424 a          668 c          785 g         1157 t
ORIGIN      
        1 aaaggaggag atagttatta taaactacaa gtggatattg tgtcctgtat gtggaaataa
       61 aacacgatta aagataaggg aagatactga attaaaaaaa ttccccctct attgtccgaa
      121 atgcagacaa gaaaatttaa ttgaaataaa gcagttcaaa gtaactgtga ttacagagcc
      181 agacgcaaag acgcagagcc gataaaatga gattaataca atctcatttt atcggctctt
      241 tccgttatgt atggattctt ttaattagtc ttcgatgttt cttgcttcgt tgataccgct
      301 ggctaaagat tccattaagg atagttcttt gtctgtaaag ctatccatgt atttctctat
      361 ctgtaatcgt cgggtgcttt ttaccaagtt attagcaggt aagaaaaatt catcaacgga
      421 aacatgaagt aacgatacaa ggtcataaag aacttgtatg ctggggtgtt gccctttatt
      481 ttcaatatta gttaagtacc gtgggtcaat ttcaatcaat gctcccactt gttcacgagt
      541 taaacctcgt ttcaatcgag cttctttaat ggctaaacca aaggctctaa aatcatattt
      601 atcttctttt ttacgcatag tagaccacct ctatacattt tattgttcct actgaattaa
      661 aaacaggtat agaaaaacgt gttatatggt ttataggttt atatttaata aaaagcacta
      721 ctaaacgcca ataaaaaaaa ccgttatatg gtagtgctat ttacgctgtt aaaatattgt
      781 atattacttc caaatggcgg tttgttggag gtcaacgtcg ccatgaagta catcatatac
      841 aataaatttc cttacattgg gttcttgtca aaaaaagtcg tctatctgca atagataagt
      901 acgtccacca atgtggtttt ataaatcata tagatagaat aacagaagca tgtaaacaga
      961 gaaataaatc tgtttatatg cttttttggc tattcagaac ttttttacaa agtttattta
     1021 tcagtaatgc aacaaatccc cctttcacat tgggactaag agtgaaagga gataaacgag
     1081 caaggctcac ttcctttcct agacagaaag ggggtgagaa acatgaaacc atcttctttt
     1141 cagaccacaa tagaaaatca gtttgactat atctgtaaac gtgctatgga agacgagcga
     1201 aagaattata tgctttatct ttcaaggatt gcaaagcgtg aggtgtcctt ttcggatgtt
     1261 ggcgattatc ttgttagcca gtttgcgaca acagataact attcaactga ctttcagatt
     1321 tttacactca atgggttatc agtaggcgtt gaaaatgatt tgttgagtga agcattacgt
     1381 gagttgccag acaagaaacg tgaaattcta ctgctgtttt actttatgga catgagcgat
     1441 tcagaaattg cagacctgtt gaaattgaac cgttctactg tctatcggca tagaaccagt
     1501 ggactagcct taattaaaaa gtttatggag gaatttgaag aatgaaaaca caatatccta
     1561 tgattccctt tcctctcatt gtaaaggcaa cagatggcga taccgaagcg attaaccaga
     1621 ttctacatca ttacagaggg tacataacga agcgttccct acgacttatg aaagatgaat
     1681 atggcaatca aagtatggtc gttgatgaag tcttacgtgg aagaatggaa accagactga
     1741 ttacaaagat tttgtcattt gaaattaagt aatatcctct ctcctttcgt ggaagcgtgc
     1801 taaaccattc cacgcttccc gaacagggag gtttgttatt ccaccaaagc atattgagct
     1861 ttcaatgtgt tttgataggc taacgagcca ttgttctttg aaaactgaat aaaagtaatc
     1921 gaatacgttt cgataagaaa agagccaacg gaactaaccg ccatgaccta tcttataaag
     1981 atagcgagcg attcatgtta gtgatccgag aagcaatctt tagcaggatt gcctgcaacg
     2041 acattcttat cgtgataatg atactcccat acagtcaata gtccgagcgt gataaaaccg
     2101 tcgcaggcaa tgagtatggc tacatgagaa ccatgcaggg gtggaactcc cgtgagcttt
     2161 gctaaagctg ttcgattgct ggtaaaacaa cttttatgaa atccaaataa gtgatttgga
     2221 aaggaggatt ttatgaagca gactgacatt cctatttggg aacgttatac cctaaccatt
     2281 gaagaagcgt caaaatattt tcgtattggc gaaaacaagc tacgacgctt ggcagaggaa
     2341 aataaaaatg caaattggct gattatgaat ggcaatcgta ttcagattaa acgaaaacaa
     2401 tttgaaaaaa ttatagatac attggacgca atctagcgtc gccaaagggt cttgtatatg
     2461 ataaaatagt attaagtcgt atcaaggctc tttccataaa ggaaaggagc aaatgccatg
     2521 tcagaaaaaa gacgtgacaa taaaggtcga atcttaaaga ctggagagag ccaacgaaaa
     2581 gacggaagat acttatacaa atatatagat tcatttggag aaccgcaatt tgtttactcg
     2641 tggaaacttg tggctacaga ccgagtacca gcaggaaagc gtgattgtat ctcacttaga
     2701 gagaaaatcg cagagttaca gaaagacatt catgatggta ttgatgttgt aggaaagaaa
     2761 atgacactct gccagcttta cgcaaaacag aacgctcaaa gaccaaaggt tagaaaaaac
     2821 actgaaactg gacgcaaata tcttatggat attttgaaga aagacaagtt aggtgtaaga
     2881 agtattgaca gtattaagcc atcagacgct aaagaatggg ctattagaat gagtgaaaat
     2941 ggttatgctt atcaaaccat caataactac aaacgttctt taaaggcttc attctatatt
     3001 gctatacaag atgattgtgt tcggaagaat ccatttgact ttcaactgaa agcagttctt
     3061 gatgatgata ctgtccctaa gaccgtacta acagaagaac aggaagaaaa actgttagcc
     3121 tttgcaaaag ctgataaaac ctacagcaaa aattatgatg aaattctgat actcttaaaa
     3181 acaggtcttc gtatttcaga gtttggtggt ttgacacttc cagatttaga ttttgagaat
     3241 cgtcttgtca atatagacca tcagctattg agagatactg aaattgggta ctacattgaa
     3301 acaccaaaga ccaaaagtgg cgaacgtcaa gttcctatgg ttgaagaagc ctatcaagca
     3361 tttaagcgag tgttagcgaa tcgaaagaat gataagcgtg ttgagattga tggatatagt
     3421 gattttctct ttcttaatag aaagaactat ccaaaagtgg caagtgatta caacggcatg
     3481 atgaaaggtc ttgttaagaa atacaataag tataacgagg ataaattgcc acacatcact
     3541 ccacatagtt tgcgacatac attctgtacc aactatgcaa atgcaggaat gaatccaaag
     3601 gcattacagt acattatggg acatgctaat atagccatga cgctgaacta ttacgcacat
     3661 gcaacattcg attctgcaat ggcagaaatg aaacgcttga ataaagagaa gcaacaggag
     3721 cgtcttgttg cttagtagta caaatgaatt tactacttat ttaccacttc tgacagctaa
     3781 gacatgagga aatatgcaaa gaaacgtgaa gtatcttcct acagtaaaaa tactcgaaag
     3841 cacatagaat aaggctttac gagcatttaa gaaaatataa aaagataatt agaaatttat
     3901 actttgttta tattaaaaaa aagaaataaa atcataatca ttgtcgagca tagattattt
     3961 tatttgaaag acattgtaga caagctgtgt gtaatagaaa ataaaacttt taaagaatac
     4021 acgaaagaat attt
//
LOCUS       DAVHSO010000102         3972 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.103, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000102 DAVHSO010000000
VERSION     DAVHSO010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3972)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3972)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3972
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.103"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            2..322
                     /locus_tag="VVR18_002149"
     CDS             2..322
                     /locus_tag="VVR18_002149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001216095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033595.1"
                     /translation="MRHKFQQVLDKIHDFLNGHDQPDQTETNSLTATIEEAIQKQTAV
                     HLILSETSFTGDIIKYDQQGQQIIVKNFAKNVSRIIRISDIQRLRFVPSTVQTAQKNR
                     FKKE"
     gene            complement(353..691)
                     /locus_tag="VVR18_002150"
     CDS             complement(353..691)
                     /locus_tag="VVR18_002150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033596.1"
                     /translation="MQVIKRNGEIAEFNPDKIYQAILKAAQTVYVLTDDLRQNLAQVT
                     KKVVLDLQEAKVERATISMIQSMVEHRLLGAGYITIAEHYISYRLQRDLERSGYGDHI
                     AVHLHFEQIR"
     gene            complement(703..1422)
                     /gene="trmD"
                     /locus_tag="VVR18_002151"
     CDS             complement(703..1422)
                     /gene="trmD"
                     /locus_tag="VVR18_002151"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HEU6033597.1"
                     /translation="MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKA
                     RHVDDEPYGGGQGMLLRAQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEE
                     LIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSH
                     QDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLL
                     EHYQLTVEEEKMLAEIKENKE"
     gene            complement(1412..1930)
                     /gene="rimM"
                     /locus_tag="VVR18_002152"
     CDS             complement(1412..1930)
                     /gene="rimM"
                     /locus_tag="VVR18_002152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimM"
                     /protein_id="HEU6033598.1"
                     /translation="MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELALFDEK
                     DQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYH
                     EIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRV
                     DVEILEGLDDED"
     gene            complement(1961..2749)
                     /locus_tag="VVR18_002153"
     CDS             complement(1961..2749)
                     /locus_tag="VVR18_002153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU6033599.1"
                     /translation="MKRFEVSTEIGSLSVAYQKQKKVLVCLNGAGLLPSYENFSLILE
                     KPPPTIGYLTIDFPNTGRSPIHDQAGKNLDNLADVVYEALEELGISEYILCVHSWSGI
                     LACKLLEKPIKCQTLVAIEPTTKKVMFADFSENPYPEMEEQMRLIDECGPELYFKNLT
                     QATFSPETNKKIWELMQEKGLELENQDPEFQISGEITEEDFENLSIESHVPVFIFCQT
                     YREKEYRESEYWTSNTKLILGGNHHYLQWSESEKIAAIIRELSE"
     gene            complement(3326..3565)
                     /locus_tag="VVR18_002154"
     CDS             complement(3326..3565)
                     /locus_tag="VVR18_002154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HEU6033600.1"
                     /translation="MDTIENLIIAIVKPLISQPDALTIKIEDTPEFLEYHLNLDQSDV
                     GRVIGRKGRTISAIRTIVYSVPTEYKKVRIVIDEK"
     gene            complement(3585..3857)
                     /gene="rpsP"
                     /locus_tag="VVR18_002155"
     CDS             complement(3585..3857)
                     /gene="rpsP"
                     /locus_tag="VVR18_002155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HEU6033601.1"
                     /translation="MAVKIRLTRMGSKKKPFYRINVADSRSPRDGRFIETVGTYNPLV
                     AENQVTLKEDRVLAWLANGAQPSDTVRNILSKEGVLKKFHDSKFSK"
BASE COUNT         1145 a          863 c          660 g         1304 t
ORIGIN      
        1 tatgagacat aaattccagc aagttctaga taaaatacat gattttttaa atggacatga
       61 ccaacctgac cagactgaaa ccaactccct tacagccact attgaagagg ctatccagaa
      121 acaaaccgct gttcacctta tcttgtctga gacaagcttt acaggtgata tcatcaaata
      181 tgatcagcaa ggccagcaaa ttatcgtgaa aaattttgcc aaaaatgtga gccggattat
      241 ccgtataagc gatattcaac gcctgcgatt tgtcccctca actgtccaaa cagcccaaaa
      301 aaatagattt aagaaagagt gagatgtagt tgcttcatcc cactcttttt tcttagcgaa
      361 tttgttcaaa atgtaaatga actgcgatat gatctccata accacttctt tccaagtcac
      421 gttgtaaacg ataggaaatg tagtgttctg caatggtaat gtaacctgcg cccaataaac
      481 gatgttcaac catagattga atcatactga tagtcgcacg ttccaccttg gcttcttgta
      541 aatccaaaac taccttctta gtgacttgag caagattttg acgcaaatca tctgtcaaaa
      601 cataaacagt ttgggctgcc ttcaagatgg cttggtaaat cttatctgga ttaaattcag
      661 caatttcgcc attacgtttg attacttgca taggtttctc ctttattctt tgttttcttt
      721 gatttctgcc agcatttttt cttcttctac tgtcagttga taatgttcaa gtaaatccgg
      781 tctgcgctcg taggttttct ttaaactctc gtacaatcgc cactgacgaa tcttttcatg
      841 gtggccactc atcaatacat ctggcacgac catgcctcga taatcatagg gacgtgtgta
      901 ctgaggatat tctaaaagac ctgaagaaaa actatcatct tggtggctag actccttgcc
      961 aatcacttct ggaatcaggc gaactgtagc atcaatcatg gtcatagctg ccaattctcc
     1021 accagtgagg acatagtcgc ctagggaaat ctcatctgtt accaaggtct taatgcgctc
     1081 atcataaccc tcatagtgcc cacagataaa gattagctct tcctcttgag ccaaatcttc
     1141 agcataagcc tgatcaaact gctttccagc aggatcaagg agaataacgc gcggattttt
     1201 cttttcaata gcatcaaagg aatcgaaaat aggttgtgct ctgagcaaca tgccctgacc
     1261 gcctccgtag ggctcatcat ctacatgacg ggccttttca gcattttctc gaaaattatg
     1321 atactggata tccaagagcc ctttttctcg agcctttcca acgattgagt gctccagtgg
     1381 agaaaacatc tctggaaaga gggttaaaat atcaatcttc atcgtctaac ccttctaaga
     1441 tttccacatc gacccgttta tttggaatat caacattgag aaccactggt gggatataag
     1501 gtaaaagcaa atcacgtttg ccttttcgtt tgaccaccca gacatcatta gcacctggtt
     1561 gcaggatttc cttgatggtt ccaaccaagc tatcaccctc atagacttcc aaaccgataa
     1621 tctcgtgata gtaaaattca ccatcgtcta ggtcattcaa atcttcctca gcgaccttga
     1681 gactgtatcc cttgtacttt tcgatagtat tgatatggta catatctttg aatttaataa
     1741 tgtcaaagtt cttctgttta cggtggctag cgatggtcac tgtttggaca aactgatctt
     1801 tttcatcaaa caaagccagc tcagctcctt ttttaaaccg ttcttctgca aaatccgtca
     1861 cagacaagac tcgcatctca ccctgtaatc cctgcgtatt aacgattttc ccaacattaa
     1921 agtagttcat cttgtctcct gtaatctcct tttttccatc ttattctgac aattctcgaa
     1981 taatagccgc aattttttcc gattctgacc attgtaaata atggtgattc cctcctaaaa
     2041 tgagtttagt attggaagtc caatattctg attctctgta ctctttttct ctataagtct
     2101 gacaaaaaat aaatacaggg acatgagatt ctatcgacaa attctcaaaa tcttcctcag
     2161 taatctctcc agatatctga aattctggat cttgattttc caactctaag cctttttctt
     2221 gcattaattc ccagattttt ttattcgttt caggactaaa tgttgcttga gttaagttct
     2281 taaaataaag ttcaggacca cactcgtcaa tcagcctcat ctgctcttcc atttctggat
     2341 aaggattttc tgaaaaatca gcaaacatga cttttttagt tgtcggttca attgctacta
     2401 aagtctgaca cttaattggt ttctcgagta atttgcaagc taaaattcca ctccaactat
     2461 gtacacaaag tatatattca gaaatcccta attcttcaag tgcttcataa accacatctg
     2521 caagattatc tagatttttt ccagcttggt catgaatcgg actcctacct gtgttcggaa
     2581 aatcaattgt caaataacca attgtaggag gaggtttttc aagtataagt gaaaaatttt
     2641 cataacttgg tagcaaacct gctccgttta gacaaactag cactttcttt tgcttttgat
     2701 aagcaacaga gagactacca atttctgtag atacttcaaa cctcttcata aagaaatcca
     2761 ctgattctat ataatgaatt attaaaaatc cttatccttt attttatcac gttccaagga
     2821 ttttctcaag ttggaggaag gggacaatat ctctactttc ccttcaataa tccttccaaa
     2881 ttatgtttat gttggtaatt aacggctgcg gttttgtctt tctcaaagac agtcttggta
     2941 aggtcaatat gattaatagc tacgattgcg acggtgtagt aaatgatatc agccagttct
     3001 ctggcaagtc cctcgttcga atcctatccc ttcttttcga ccagagcgcc tattcaaaac
     3061 ctcggctact tctccgactt cctccactaa cttcataaag agaccttcat cagtccgaga
     3121 ctgctgttaa tgttcgatta agtagtcttg gaattgccta aacgttcaat cttttatagt
     3181 atattgaaac tagaatagta cacctttact tctaaaacat tgttagaaat cgatttgact
     3241 gtcctgatcg atttgtcctg ttcttgtttc attttactat atcttctatt ccacacaaaa
     3301 aagcgagaca tccgtcccgc ccttcttatt tttcgtcaat aacgattctt acttttttgt
     3361 attcagttgg gacagagtag acaatcgttc ttatcgcaga aatagtgcga cccttacgac
     3421 cgattacacg acccacatcg ctttgatcaa gattcaaatg atattccaaa aattctggtg
     3481 tatcctcaat cttgatagtt aaggcatctg gttgtgaaat taagggtttc acaatcgcaa
     3541 taatgagatt ttcaatcgta tccatctgtc aacctacttt aaacttattt tgaaaattta
     3601 gaatcgtgga attttttcaa tacgccttct tttgaaagga tgttacgtac tgtgtctgaa
     3661 ggttgagctc cattagccaa ccatgcaaga acgcggtctt ctttcaaagt tacttggttt
     3721 tcagcaacaa gtgggttgta agttccaact gtttcgatga aacgtccgtc acgtggtgaa
     3781 cgtgaatctg ctacgttgat acggtagaaa ggttttttct tagaacccat acgagtcaaa
     3841 cggattttaa ctgccatttt taaagtctca tttctttaat tttttatttt ggtgaaatag
     3901 ctgagctatt tagcacatgt tctattatag cagatttctg gcatgtgtca agaaaaaaac
     3961 ttgacagact at
//
LOCUS       DAVHSO010000103         3302 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.104, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000103 DAVHSO010000000
VERSION     DAVHSO010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3302)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.104"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(250..861)
                     /gene="rpsD"
                     /locus_tag="VVR18_002156"
     CDS             complement(250..861)
                     /gene="rpsD"
                     /locus_tag="VVR18_002156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HEU6033602.1"
                     /translation="MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKL
                     SEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRL
                     GLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATL
                     GRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML"
     gene            complement(1056..2108)
                     /locus_tag="VVR18_002157"
     CDS             complement(1056..2108)
                     /locus_tag="VVR18_002157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000769768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEU6033603.1"
                     /translation="MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTI
                     VASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEM
                     SHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
                     TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERR
                     DVHLQVIPESARIEGDYAKLSRILVNLVDNAFKYSAPGTKLEVVTKLEKGQLSISVTD
                     EGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGEITVSSQYGLG
                     STFTLVLNLSGSENKA"
     gene            complement(2105..2803)
                     /locus_tag="VVR18_002158"
     CDS             complement(2105..2803)
                     /locus_tag="VVR18_002158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000520636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6033604.1"
                     /translation="MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKK
                     KPIDLIITDVMMPRMDGYDLISEVQYLLPEQPFLFITAKTSEQDKIYGLSLGADDFIA
                     KPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
                     LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTV
                     WGLGYKIEKPRGQT"
     gene            complement(2970..>3302)
                     /locus_tag="VVR18_002159"
     CDS             complement(2970..>3302)
                     /locus_tag="VVR18_002159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU6033605.1"
                     /translation="INVKETSDTANGSLSPSNSGSGVTPMNHNHATGTTDSMPADTMT
                     SSTNTMAGENMAASANKMSDTMMSEDKAMLPNTGETQTSMASIGFLGLALAGLLGGLG
                     LKNKKEEN"
BASE COUNT          930 a          743 c          626 g         1003 t
ORIGIN      
        1 gttatactac ctgttcgctc acaataagag agaacttttt tacgaaaatc tattgaatat
       61 gccataaaag attataccac attgtgtact atttttggtt cattttacta tatcactttg
      121 gactatatcg gtctagttat gtctcaacga ttatagctgg atactaagag aaatcaaaaa
      181 agcactaagg gagaacgtcc caaagtgctt aatatcaagg cctcaaagcc tgtcttattc
      241 aataaaatat tacaacatct tgttgtagaa ttcaacgaca agtgcttcgt tgatttctgg
      301 gttgatttcg tcgcgttctg gcaagcgagt caatgaacct tccaactttt cagcgtcgaa
      361 tgatacgaat gctggacgtc caagagtagc ttctactgct tcaaggattg ctggaacttt
      421 caatgatttt tcacgaactg agatcacttg acctggagtt acgcggtatg atgggatatc
      481 aacgcgtttc ccgtcaacaa ggatgtgacc gtggtttacg aattgacgag cttgacgacg
      541 agtagtcgcg agaccaagac ggtaaacaac attatccaaa cgacgttcca aaagaagcat
      601 aaagttgaaa cctaggattc cacctttgat ttttgtagct tgtacgaaca agttacggaa
      661 ttgtttttca cctacaccgt aagtgaaacg aagtttttgt ttttcagcca attgcaaacc
      721 atattctgac aatttagaac ggttgtttgg tccgtgttgt cctggtacgt agttacgacg
      781 tgccaattct ttacctgtac ctgtaagtga aaggccaagg cgacgagctt gtttccaaga
      841 tggtcctgta taacgtgaca tatgaatgtc ctcctgatat aaataatatt tcggtggaaa
      901 tagtcactta gaaagccctg attcgtgcag atgcccttcg cctaaacagc caaggttact
      961 tgtcataaga cacctgttga cgagcttcat gctttcctgc tgatatttca cacaaaatcc
     1021 attttaccat gaatagctgg atttgtaaag gagttttagg ctttattttc actaccagag
     1081 agattgagaa cgagggtaaa ggtacttcct agaccgtact ggctgctgac tgtgatttcc
     1141 ccacccaatt gatgggccaa ttcacgcgca atcgcaagtc ctaatccatg gccacctgtc
     1201 ttcatgttac gcgaagtttc gacacgataa aggcgtttga aaatattttc caaatcctct
     1261 ggggcaatgc cctgcccttc atcggtcaca ctgattgaaa gctggccctt ctccagctta
     1321 gtcaccactt ccagcttggt tcctggagca gaatatttaa aagcgttatc gaccagattc
     1381 accaagatac gagaaagctt agcataatct ccctcaatcc gggcagactc tgggattact
     1441 tgcaagtgga catctcttct ctcctgctca atcaaaaact gaaattcact catgcactca
     1501 attaagagct tgtccagaaa aatactgtct ttactggtag tttccacctg atttctagct
     1561 gtatttaggg tcaaaaaatt caactcctca accagtttat tgagcctctc cgtctggcgt
     1621 ccaatggttg ctagataatg agcttgctcc gactccttga taatcccatc caaaatccct
     1681 tctaccgtcg cttgaatcga agtgataggg gtcttaatat catgcgacaa ctgggcaatc
     1741 atcaagccct tttctcgttc gctttcttcc aaggaatcaa agcttacctg caaatcatgg
     1801 gacatctcat taaaagtttg ccctaattgc tgaaattcta caggaccttg aacctccaaa
     1861 tttgaaggaa aatccttggc cgctacccgc ttggcatgct ccttgagttt gcccaacgac
     1921 gtaaagactg gcaataggag aaagagacta atcccagcac cgacaaggct ggcaacgatg
     1981 gtcatcccaa gcaaaaagta aatctcgcct ttcgcaatca gcattttttg aacagcccaa
     2041 aaaacaacca aaatggttaa gagggttgaa ataatatatc caaccaaaat ataacttttt
     2101 agtttcatgt ttgtcctctc ggtttctcta tcttatatcc caacccccaa actgtcttaa
     2161 tagtgggcgt ttggtcacta ctatattttg ccagctcctg tcgaagagca tggatatgca
     2221 cattcaaggt attggtgtca tccacgtagt cttctttcca gatcttttca tagaggtctg
     2281 tcttggagaa aactcgctct ggattgctag ctaaaatcca cagcaattca aatgatttaa
     2341 cagttaaatc cagcatttct tctcctattt gaacttcatg actactatga ttcattttta
     2401 gattgccaag ggaaatcagc tctgtttcgc ccccacgatg aaggcggcgc aaaatattgt
     2461 ggacacgcaa aactagctca cgtgggctaa aaggcttagc aataaaatca tctgctccca
     2521 agctcaggcc gtaaatcttg tcctgttcac tggtcttagc agtaataaat aggaaaggct
     2581 gctctggtaa taagtattga acctcactga ttaaatcata accatccatc cgaggcatca
     2641 tgacatctgt gataatcaaa tcaatcggtt ttttcttgaa cagctctagc gcttccagtc
     2701 catcatgggc taccaagacc tgataacctg cctgaattaa gtatctctga tgaatatctg
     2761 tgatttctac ctcgtcgtca acgagtaaaa ttgtctttcc catctgtctc tcctttgata
     2821 aaaacagtgc tatactgctt taagtataac actattttta ttgttttacg atgattttaa
     2881 tctgctattg aaagaaagtc ctgattgctg attgagttgt taaactaatc ttagtcagcc
     2941 cactatccat catttatttc cttagctgat tagttttctt cttttttgtt tttcaaacct
     3001 agaccaccga gtaaacctgc aagcgcaagc ccaaggaaac caatacttgc cattgatgtt
     3061 tgagtctcac cagtatttgg tagcatagct ttatcctctg acatcatcgt atcagacatc
     3121 ttgttagcag aagcagccat gttttcacct gccatcgtgt tggtagaact tgtcatggtg
     3181 tcagcaggca tgctatctgt agtacctgta gcatgattgt gattcatcgg agtcacgcca
     3241 gaaccagagt tagaaggtga taatgaacca tttgctgtgt ctgatgtttc tttaacattt
     3301 at
//
LOCUS       DAVHSO010000104         3295 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.105, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000104 DAVHSO010000000
VERSION     DAVHSO010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3295)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.105"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..652
                     /locus_tag="VVR18_002160"
                     /pseudo
     CDS             1..652
                     /locus_tag="VVR18_002160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153810.1"
                     /note="internal stop; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            624..1268
                     /locus_tag="VVR18_002161"
     CDS             624..1268
                     /locus_tag="VVR18_002161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VIT family protein"
                     /protein_id="HEU6033606.1"
                     /translation="MLRAGVLGANDGIISIAGVVIGVASATTNIWIIFLSGFAAILAG
                     AFSMAGGEYVSVSTPKDTEEAAVSQEKLLLDQDRELAKKSLYAAYIQNGECKTSAQLL
                     TNKIFLKNPLKALVEEKYGIEYEEFTNPWHAAISSFVAFFLRSLPPMLSVTIFPSEYR
                     IPATVLIVGVALLLTGYTSARLGKDPTRTAMIRNLAIGLLTMGVTFLLEQLFSI"
     gene            complement(1310..>3295)
                     /locus_tag="VVR18_002162"
     CDS             complement(1310..>3295)
                     /locus_tag="VVR18_002162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU6033607.1"
                     /translation="FRLTNKLAVSNLIKNRKLYYPFALAVLLAVTITYLFYSLTFNPK
                     IAEIRGGTTIQATLGFGMFVVTLASAIIVLYANSFVMKNRSKELGIYGMLGLEKRHLI
                     SMTFKELVLFGILTVGAGIGIGALFDKLIFAFLLKLMKLKVELVATFQMKVVITVLLV
                     FGLIFLGLMFLNALRIARMNALQLSREKASGEKKGRFLPLQTILGSISLGIGYYLALT
                     VKDPLTALTTFFLAVLLVIFGTYLLFNAGITVFLQILKKNKKYYYQPNNLISVSNLIF
                     RMKKNAVGLATIAILSTMVLVTMSAATSIFNSAESFKKVLNPHDFGVSGQNVEKEDLD
                     KLLSQFASDKGYKIKEKEVLRYTYFAVTNQEGTKLTIFEKGQNRVQPKTVFMVFDQKD
                     YENMTGQKLSLSGNEVGLFVKNDGLKGQKTLTLNDHQFSVKEEFNKDFIVNHVPNKFN
                     ILTTDYNYLVVPDLQAFLDQFPDSAIYNQFYGGMNVDASEEEQLKVAEEYENYLNQFN
                     AQLDTEGSYVYGSNLADASSQMSALFGGVFFIGIFLSIIFMVGTVLVIYYKQISEGYE
                     DRERFIILQKVGLDQKQIKQTINKQVLTVFFLPLLFAFIHLAFAYHMLSLILKVIGVL
                     DTTMMLIVTLSICAIFLIAYVLIFMITSRSYRKIVQM"
BASE COUNT         1035 a          651 c          668 g          941 t
ORIGIN      
        1 aagcaagcag gatctgcttt accctagaaa aggaaaagcg cttaagaaac aggctagcac
       61 caactttaaa cctgctggtc aatccatcga acagcggcct gaagctatca atcttcgctt
      121 ggagaatggg cattatgaga ttgatacggt tctacttacg agatcgaaaa actactgctt
      181 gcttgtcttg acggatcgaa agagtagaca tcagatcatc cgattgattc caaataaaag
      241 tgctgaggtg gtcaatcagg ctctaaaact catcttaaaa caacacaaga ttctttccat
      301 cacggcagat aatggaacgg aattcaatcg cttgtttgat atattttctg aggagcacat
      361 ctattatgcg cacccctatg cctcttggga aaggggaact aatgagaatc acaacaggct
      421 cattcgtaga tagttaccta agggaaccaa gaaaatgact cccaaagaag tcgcattcat
      481 cgaaaagtgg attaacaact atcctaaaaa atgcttggac tacaagtcac ccagagaaga
      541 cttctggatg gctaacttga acttgaaatt tagcgtcaga aacaaatcac gaaatcgatt
      601 caaattttgc aggtcgttta aatatcctac gcgcaggtgt tcttggtgct aacgatggaa
      661 ttatttccat tgctggtgtg gttatcgggg ttgccagtgc cacgaccaat atctggatta
      721 tctttttatc aggatttgcg gctatcttag ctggtgcctt ttcaatggct ggtggagaat
      781 atgtatccgt ttcaactcca aaagataccg aggaagctgc cgtttcgcaa gaaaaactct
      841 tgttagacca agatagggaa ctagccaaaa aatccctcta tgctgcttat atccaaaatg
      901 gagaatgcaa aacttctgcc caactcttga ccaataagat ctttcttaaa aatccactca
      961 aggctctggt agaggaaaaa tatgggattg agtatgaaga atttaccaat ccttggcacg
     1021 ctgccatttc tagcttcgtt gcctttttcc ttagaagttt gcctccaatg ctgtcagtga
     1081 ccatattccc aagtgaatat cgcatccctg ctactgtcct tattgtcggt gtggcccttc
     1141 ttctcactgg ttacactagt gccagacttg gaaaggatcc gactagaaca gctatgattc
     1201 ggaaccttgc tattggtctc ttgaccatgg gagttacctt cctgctcgaa caacttttca
     1261 gcatttagaa tacaagaaat acctcgattt tgaagtcgag gtatcttttt tacatttgca
     1321 caatcttgcg ataacttctt gaagtaatca tgaaaatcag cacataggcg atgaggaaga
     1381 tagcgcagat agacaaggtc acaatcaaca tcatagtcgt atccagtaca ccaatcactt
     1441 ttaaaatcag gctaagcata tggtaggcaa aggcgagatg tatgaaggca aagagcaaag
     1501 gaaggaagaa aacagttaaa acctgtttgt tgatggtttg cttgatttgc ttttggtcca
     1561 aaccgacttt ctgcaagata ataaagcgtt cacggtcttc gtagccttca gaaatttgtt
     1621 tgtagtagat gaccagaaca gttccgacca taaagataat ggataggaaa ataccgataa
     1681 agaagacacc accaaagagg gcactcatct gagaactagc atctgctaga ttgctaccat
     1741 aaacatagct accttctgtg tctaattgag cattaaattg attgaggtag ttttcatact
     1801 cctcagcgac cttgagttgt tcttcttcgc tggcatctac attcatacca ccgtaaaact
     1861 gattatagat agccgaatct gggaattgat ccaaaaaggc ttgtaaatca ggaacaacaa
     1921 ggtaattgta atcagtagtc aagatattaa acttatttgg aacatggttg acaatgaaat
     1981 ctttattaaa ttcttctttg acagaaaatt gatgatcatt tagagttaga gttttctgtc
     2041 ctttcagtcc gtcatttttg acaaagagac cgacctcatt tcctgataga gacagttttt
     2101 gaccagtcat attttcataa tctttttggt caaataccat gaaaactgtt tttggttgga
     2161 cacggttttg tcctttttca aaaatagtta acttggttcc ttcttgattc gtaacagcaa
     2221 agtaagtgta acgaagcact tctttctctt taatcttata acctttgtca cttgcaaact
     2281 ggctcaagag tttgtccaaa tcttcttttt caacattttg ccctgaaacc ccaaaatcat
     2341 gaggatttag aactttttta aaggattctg cggaattgaa aatgcttgtc gctgctgaca
     2401 tggttaccaa aaccattgtt gacaaaatag cgatagttgc tagtccaact gcatttttct
     2461 tcatacggaa aatcaagtta gaaacagata tgagattatt aggttggtaa tagtatttct
     2521 tatttttctt taagatttga agaaaaacgg taatccctgc attgaacaaa agataagtac
     2581 caaagataac cagtaaaaca gctaggaaga aggttgttaa ggctgtaaga ggatctttta
     2641 ccgtaagggc aagataatat ccaatcccta aacttatgga accaagaata gtttggagag
     2701 gaaggaagcg accttttttc tctccgctag ctttctcacg tgagagctgg agggcattca
     2761 tacgggcgat tcgaagggca ttcaggaaca tgaggcctag gaaaatcaaa ccgaagacaa
     2821 gaagtactgt aatgacaact ttcatctgga aggtagcgac cagttccacc ttcaatttca
     2881 tcagtttgag taggaaagcg aaaatcaact tgtcaaacaa ggctccaata ccgattcctg
     2941 ctccaacagt tagaatccca aatagcacta actccttaaa ggtcatactg attagatggc
     3001 gcttctccaa gcctaacatg ccatatatac ccagttcctt ggaacggttt ttcatgacaa
     3061 aactattggc atagaggacg ataatggctg acgcaagggt aacgacaaac ataccaaatc
     3121 caagtgttgc ttgaatggtg gttcctccac gaatttccgc aatcttggga ttgaaggtta
     3181 gggagtaaaa gagataggtg atggtgactg ccaagagaac agccagtgca aagggatagt
     3241 agagtttgcg gtttttaatc aagttcgata ccgctaactt attggttaat cgaaa
//
LOCUS       DAVHSO010000105         3294 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.106, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000105 DAVHSO010000000
VERSION     DAVHSO010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3294)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.106"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..135)
                     /locus_tag="VVR18_002163"
     CDS             complement(<1..135)
                     /locus_tag="VVR18_002163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033608.1"
                     /translation="MAYSIDFRKKVLSYCERTGSITEASHVFQISRNTIYGWLKLKEK
                     T"
     gene            complement(266..1138)
                     /locus_tag="VVR18_002164"
     CDS             complement(266..1138)
                     /locus_tag="VVR18_002164"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HEU6033609.1"
                     /translation="MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV
                     SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL
                     TCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGY
                     NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGA
                     DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK
                     SLDFSMKGLTYLDV"
     gene            1375..2685
                     /locus_tag="VVR18_002165"
     CDS             1375..2685
                     /locus_tag="VVR18_002165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HEU6033610.1"
                     /translation="MIHLIMISAIALAIGIGYRTKINIGLLAIAFSYLIATTLMGLSP
                     KELLHFWPTSLFFTIFSVSLFYNVATTNGTLDVLAQHILYRTRTYPNALYMILYLMAT
                     LLSALGAGFFTTMAVCCPLAITLCQKADKHPLIGAQAVNWGASGGANLITSSSGIVFQ
                     GLFKQMGWEEQAFSLGNHIFIVSIIYPLIVLLLLSCYSHYSKGRTNSSLTIDQPPLLS
                     KVQRQTTLLMISSMVLVWLFPLLHLIFPNIAWIATYQKTFDIGFVSILMVCLALRLKL
                     GKQEAILAKVPWATIIMLCGMSLLMSLAVKSGLVTLIGHLMTTTIPHFWLPLFFCVIA
                     GVMSLFSSTLSVVAPALFPIIAIISAQNPQIDIHLLTTATVIGALSTNISPFSSAGSL
                     IQLSLPNIEERGLAFKKQIILGVPISLSLGLLTTWILILLASLS"
     gene            complement(3051..3245)
                     /locus_tag="VVR18_002166"
     CDS             complement(3051..3245)
                     /locus_tag="VVR18_002166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEU6033611.1"
                     /translation="MKGKEYENRTVSFAISSKGEKMKVENISYRVDHRILFDNISFDT
                     LSSGVTLITGKNGTGKSTLL"
BASE COUNT          990 a          736 c          542 g         1026 t
ORIGIN      
        1 tgttttctct tttagcttta accagccata aatggtatta cgtgagattt ggaaaacgtg
       61 tgatgcttct gttatactac ctgttcgctc acaataagag agaacttttt tacgaaaatc
      121 tattgaatat gccataagaa gattatacca cattgtgtac tatttttggt tcattttact
      181 atatttgaag aggcgtttaa actatctgac ataaaactcg ttctagagga aagacatcct
      241 ttaaaaagtt agtttatttt acaacttaga catcaaggta ggttaaaccc ttcatggaaa
      301 aatcaagact cttagcacta tgggttaaac taccactgga gacgtaatca atcgctaaac
      361 cacgaaaacg gctaatagtg gtcatatcaa tatttccaga acattcaatc cgagaacgtc
      421 ctgcaattag ggtaatggcc tgttcaatct gttccaatga catattatcc aacatgataa
      481 tatcagcacc cgccgccgca gcttcttcgg cagcagcaag gctttccact tccacctcga
      541 ccattttcac aaaaggggca taggcacgcg cttgagcaat tgccttttga acactaccta
      601 ctgccgcaat gtgattgtct tttagcatga tagcatctga taaattaaag cgatgattat
      661 agccaccgcc aactctcacg gcatatttct caaaaagacg taaattagga gtagtttttc
      721 gagtatcaaa taccttaatg caatcatcgc ctaaggcttc tacataagca gctgtcatcg
      781 aagcaatccc tgataaatgt tgtaaaaaat tcaaggcaac gcgttcacat gttaagagac
      841 ttctcaccga gcctatgatt tctaaaacca aatcgccact agtcaaacga tccccatcct
      901 taaattgatg aggattctgg aaggtcacct cggcatcaaa tagggtaaaa accctttgaa
      961 aaacggttag tcccgctaaa acaccagctt ccttggcaaa aagcgacacc ttggcttggc
     1021 catgatgatc aaaaatggca ttggtactgt aatcttcgga atgaacatct tctcgcaagg
     1081 ctgctttcaa tgtatcatct atttgaaaag gggttaaatc agttgaaatg attgacatca
     1141 ctaagtcctc tatttttaat atcacttgta agcactagag gcaatcacta ttaacttcca
     1201 taggaaatca caagcctgaa tacctcattt ttaattctaa caagtgtcaa tacaattgtc
     1261 aagacaattg tatttttttt gtgtataata gtcaagtacc aataggaaac aggtggtctt
     1321 ttgagcgcca aaattgccaa cctatttcca tattctaact gaaaggacaa ttcaatgatt
     1381 catttaataa tgattagcgc cattgctcta gccattggaa ttggttaccg caccaaaatc
     1441 aatattggcc tgctggctat tgctttttct tacctcatcg caaccactct catgggatta
     1501 agccccaaag aacttcttca tttttggcca acctcactct tttttaccat ttttagcgtc
     1561 tctctctttt ataacgttgc aacaactaac ggtactcttg atgttttggc tcaacacatt
     1621 ctctaccgca cacgcaccta ccctaacgcc ctctacatga ttttatacct gatggcaacc
     1681 cttttgtctg ctttaggtgc tggatttttc actactatgg ccgtttgctg tcctctagcg
     1741 attaccctct gtcaaaaagc ggacaaacac cctttgattg gagctcaagc cgtcaattgg
     1801 ggagcttcag gaggggctaa tttgataacc agtagctcag gcattgtctt tcaaggcctg
     1861 tttaagcaaa tgggatggga agagcaagct ttttcacttg gcaatcatat ctttatcgtc
     1921 agcattatct acccactcat cgtcttgctt ttattatcct gttacagtca ctatagtaag
     1981 ggaagaacaa actcatcctt gactattgac caaccaccac tcctcagcaa ggttcaaaga
     2041 caaaccacct tgctcatgat cagcagcatg gttttggttt ggctttttcc cttgttgcat
     2101 ctcattttcc caaacatcgc ctggatagct acttatcaaa aaacatttga tattggcttt
     2161 gtctcaatac tcatggtctg cctcgcctta aggctcaaat tagggaagca agaagccatt
     2221 ttagctaagg ttccctgggc tacaattatc atgctctgcg gcatgagctt actaatgtct
     2281 ctagcggtca agtcaggttt agtcacactg atagggcacc tcatgacaac aaccattcct
     2341 catttctggt tacctctgtt cttttgtgtg atagccggag tgatgtcact ctttagttcc
     2401 accctatccg ttgtagctcc agccctcttt cccatcattg ctatcatcag tgctcaaaat
     2461 cctcagattg atattcactt actcacaaca gccaccgtta ttggcgctct atctactaat
     2521 atctcaccct tttcatcagc tggttctctc attcaactct cacttcccaa tatagaggaa
     2581 cgtggccttg ccttcaaaaa gcaaattatt ctgggtgtcc ccatcagctt aagtttggga
     2641 ctcttgacca cctggattct catccttcta gcttccttaa gttagattta ttatctaact
     2701 taagggtgga cttggtataa taaagtagac acaaaattaa gtggaaacga ggaaaagtca
     2761 ttatgccaag aaaaaccttt gataaagcct tcaaactctc tgctgtaaac ctcatcctgt
     2821 aaaaatgatt agttcaactt taaaaattca tcccaatagt ctttatcgat ggattcaaga
     2881 atatgaaaaa tatgaagaaa gtgcgttccc aggacatggg agcgcacttc gtcatactca
     2941 atttgaaata tagtgaaatg aaataagacc aggacaaata gatcaggata gtcaaatcga
     3001 tttctaacaa tattttataa gtagatgtgt actattctag tttcaatcta ctatagtaaa
     3061 gttgactttc ctgtaccatt tttaccagta attaatgtca cgcctgaact caaagtatca
     3121 aaagaaatat tatcaaacaa tatacgatga tccaccctat acgaaatatt ttctactttc
     3181 attttttctc cttttgaact aatagcaaaa gaaacagttc tgttttcata ctctttcccc
     3241 ttcatctata ttattcgtaa tgaaaaataa aaaaaataaa atttttttaa atga
//
LOCUS       DAVHSO010000106         3222 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.107, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000106 DAVHSO010000000
VERSION     DAVHSO010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3222)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3222)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3222
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.107"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..1242
                     /locus_tag="VVR18_002167"
     CDS             <1..1242
                     /locus_tag="VVR18_002167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033612.1"
                     /translation="QIFEIISSILLFIVSLSFMLYLNFLVSIIFIVLSALPIIVPVFM
                     KKMLSNSANEYSNSNAEYTHIIKEIFNGFKTLKSYSVTKEIISLSDKKLDKLEDSTFN
                     LKRSEVLSKLVAVLISGFCFLVPLVVGCYFVIYHKSLSFSELIGIFLANDKVLGPIQS
                     IAYSLNKINTTKDLRKPFLKYLSGEKNFIDAEHDNNGLYTSSIDEIHMKDVVYSITPE
                     NKLSIDFSFKSPFRVLLTGTSGSGKTTILNLINGSLKPQKGYVNLLSHGKKSSDSIPT
                     VDQTPYIFDTTIRENVTLFQNEYFSDDQIIEVLKKVNLYEELEKIDILNYQCGENGSN
                     LSGGQKQKIALARALIRNNKVYLFDEISANLDNDNSNSIHDILFNLGISFIEVSHHYD
                     LNDKRYTDIYKLENGTLFKIK"
     gene            1257..1997
                     /locus_tag="VVR18_002168"
     CDS             1257..1997
                     /locus_tag="VVR18_002168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000356590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033613.1"
                     /translation="MDKDYILKVKGLYHQFLLGNNKTLQVLKNVSLSASRGEFISILG
                     ISGSGKSTLLKCISSLLEPTSGEVILNGINPYKIRNAKLSSIRRNEVSFIFQAYNLIP
                     SLPVIENIALPLRLSQKKLTIKNVENLLKRMKFNAGLNDFVGTLSGGEQQKVAIARAV
                     IADSDIIFADEPTGALDSVSREVIFELLRELVGAGKCVIMVTHDIELASKTDRALILK
                     DGKIFKELHRPSGEELYKILEVQSTTEE"
     gene            2000..>3222
                     /locus_tag="VVR18_002169"
     CDS             2000..>3222
                     /locus_tag="VVR18_002169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000945307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033614.1"
                     /translation="MLRLVYYQFLHNKKQWLGVSPVIFVSSLVMGLAVNGVINVENNS
                     QVFVGLPDPKPIFMFPIVFGGVTLFFVLSNIINMLVEIFRDDYELLEVLGASRLQLSF
                     LVGGQIFIISSIISFIAYLCSIFVTSNYYYFLQYFFGENILPDIQFQMSAVGCIITVV
                     LISFLAFLSGCFYTFKKIRNRKSSKIRHVLSIVKRILLLAGFSVIWLLSLQQIFQDST
                     ILAKAQIIFNIVILDIVIIYQLSPFIQSCFIKLLSIIIFRNNFMFIVSKWNLLYRKPY
                     IKSISAAITGAILLISSFQMISQNILSQFQDDSDLELKVAFIVYVGAPILIVLANIIS
                     IAFLSSHQERIEIQQFEILGTSNYQMVKIKVGEAIFLTFVTSLIAFLLNIKIIALIYY
                     SLEDILIDDMNLLGL"
BASE COUNT         1098 a          404 c          558 g         1162 t
ORIGIN      
        1 caaatttttg aaataatttc ttcaatattg ttgttcatcg tctctctaag ttttatgctt
       61 tatttaaact tcctagtttc aataatattt attgtattat cagcattgcc gattatagta
      121 cctgtcttta tgaagaagat gttgtctaat tcagctaatg agtactctaa cagcaatgca
      181 gagtatactc acataataaa agaaattttt aatggtttta agacattaaa atcttattct
      241 gttactaaag aaataattag tttgtcggat aaaaagttgg ataaactaga agattctact
      301 tttaatttga aacgatcaga ggttctttca aaattggttg cagtactaat ttcaggtttt
      361 tgctttctag ttcccttggt tgtaggatgt tattttgtaa tttatcataa aagcctttct
      421 tttagtgaac tgataggtat tttcttagca aacgataaag ttttagggcc gatacaatca
      481 attgcctatt cattaaataa gataaataca accaaagatt taaggaaacc gtttttaaaa
      541 tacttaagtg gagagaagaa ttttatagac gctgaacatg ataataacgg actgtatact
      601 tcatcaatag atgagataca catgaaagat gttgtatatt ctattacacc agaaaataaa
      661 ttaagtattg acttctcatt taagtcacca tttagggtat tattaacagg aacttctggt
      721 agtgggaaaa caacgatttt aaatttaatt aatggttctt taaagccaca aaaaggttat
      781 gtaaatttgt tatcacatgg gaaaaagagt tcagattcaa taccaacagt tgatcagaca
      841 ccatatattt ttgacactac tattcgtgag aacgtaactt tatttcaaaa tgaatatttt
      901 tcagatgatc agataattga ggtgttaaaa aaggtaaatc tatatgaaga attagaaaag
      961 atagatatac taaattatca atgtggtgaa aatggtagta atttgtctgg aggtcaaaaa
     1021 caaaaaatag ctttagctag agctctgatt agaaataata aagtgtactt atttgacgaa
     1081 atatcagcta atttagataa tgataattca aattccatac atgatattct gttcaattta
     1141 ggtatttcat ttattgaagt ttcacatcat tatgacttaa atgacaagag atacactgat
     1201 atatataaat tggaaaatgg aacacttttc aaaattaagt gattggaggc aagaatatgg
     1261 ataaagatta tatattaaaa gtgaaagggc tgtatcatca atttttacta ggaaataata
     1321 aaacgttgca agtgctgaaa aatgtttctc tttctgcttc gagaggagaa tttataagta
     1381 ttctaggaat tagtggttct ggaaagtcaa ctttattaaa atgtatttct agtttgcttg
     1441 aaccaacaag tggggaagta attttaaatg gaatcaaccc ctataaaatc agaaatgcaa
     1501 aattgtcaag tataagacgt aacgaagtat cttttatatt tcaagcatac aatttaatac
     1561 cttccctgcc ggtaatagaa aatatagcac ttcctttgcg attatcacaa aaaaaattaa
     1621 ctattaaaaa tgtagaaaac ttactcaaaa gaatgaagtt taatgctggc ttaaacgatt
     1681 ttgttggaac tctgtctggt ggagaacaac agaaggttgc tatagctaga gcggttattg
     1741 ctgatagtga tataatattt gctgatgagc caactggggc tttagacagc gtttctcgtg
     1801 aagtaatttt tgaattattg agagagttag taggggcggg taagtgtgta attatggtaa
     1861 cgcacgatat agaattggcc tcgaaaactg atcgtgcatt aatattgaaa gatggaaaaa
     1921 ttttcaaaga acttcataga cctagcgggg aagagttgta taaaatctta gaggtacaat
     1981 caactacgga ggaatagaga tgctcagatt agtttactat caatttttac ataataagaa
     2041 acaatggtta ggagtttcac cagtaatttt tgtttcgagt ttagttatgg gattggctgt
     2101 taatggggta attaatgttg agaataattc gcaagtattt gtcggacttc cagatcctaa
     2161 accaattttt atgtttccga tagtattcgg aggagtaaca ttattctttg tgctctctaa
     2221 cataataaat atgttggttg aaatttttag agatgattac gaacttctgg aggtgttggg
     2281 agcaagtcgc cttcaactat catttcttgt ggggggacag atttttatca tttcctcgat
     2341 tattagtttt attgcatatc tatgctctat atttgttacg tcaaattatt attatttttt
     2401 acaatacttt ttcggggaaa atatattacc tgatatccaa tttcaaatga gtgctgttgg
     2461 atgtatcatt acagtagtgt tgatttcatt tttagccttt ctaagtggtt gcttttatac
     2521 gttcaagaag attagaaata ggaagagttc taaaataagg catgttcttt caatagtaaa
     2581 aagaatactg ctattggctg gttttagtgt tatctggttg ctttctttgc aacaaatttt
     2641 ccaagatagc acaattttag cgaaggccca gataatattc aatattgtaa tcttagatat
     2701 tgtgattatt tatcaattat ctccttttat acagtcatgt tttatcaaac tactttctat
     2761 aattatattt agaaataatt ttatgttcat tgtttcgaag tggaatttac tatatcgtaa
     2821 gccttatata aaatctatca gtgctgcaat tacaggagct atattactaa tttctagttt
     2881 tcaaatgatt tctcagaata tactatctca atttcaagat gacagtgatt tagagctaaa
     2941 agtggcattt attgtctatg taggagcacc aattttgata gtacttgcaa atattatttc
     3001 aattgcattt ttgtcatcgc atcaagaaag gattgagatt cagcaatttg aaattttagg
     3061 aacttctaat taccagatgg ttaagattaa agttggtgag gctatatttt tgacatttgt
     3121 tacttcatta attgcatttt tacttaacat taaaattatt gctttaatat actactcttt
     3181 agaggatatt ttaatagatg atatgaatct tttggggtta at
//
LOCUS       DAVHSO010000107         3158 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.108, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000107 DAVHSO010000000
VERSION     DAVHSO010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3158)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3158
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.108"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(62..376)
                     /locus_tag="VVR18_002170"
     CDS             complement(62..376)
                     /locus_tag="VVR18_002170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003037418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIB"
                     /protein_id="HEU6033615.1"
                     /translation="MAKALIICAAGMSSSLMAQKTTEFLKGKGKDIVVDAISATEGGK
                     AIAAAAFDLYLVSPQTKMYFKQFEEAGSKAGKPVVQIPPQAYIPIPMGIEKMANLILE
                     NI"
     gene            complement(506..745)
                     /locus_tag="VVR18_002171"
     CDS             complement(506..745)
                     /locus_tag="VVR18_002171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000580385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SemiSWEET family sugar transporter"
                     /protein_id="HEU6033616.1"
                     /translation="MIGSIAAILTTFAFLPQVFRVVKTKDTGSIALGMYVMQVIGIAL
                     WLAHGIRIGDLPLILANSVSFLLSGIILFYKLKYK"
     gene            complement(797..2233)
                     /locus_tag="VVR18_002172"
     CDS             complement(797..2233)
                     /locus_tag="VVR18_002172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HEU6033617.1"
                     /translation="MTTFKDGFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVA
                     REITSGVLEGKYYPNHEAIDFYHRYKEDIALFAEMGFKCFRTSIAWTRIFPKGDELEP
                     NEEGLQFYDNLFDECLKNGIEPVITLSHFEMPYHLVTEYGGWKNRKLIDFFARFAEVV
                     FKRYKDKVKYWMTFNEINNQANYKEDFAPFTNSGIVYEEGDNREAIMYQAAHYELVAS
                     ARAVKIGHEINPDFQIGCMIAMCPIYPATCNPKDILMAMKAMQKRYYFADVHVLGKYP
                     EHIFKYWERKGISVDFTAQDKEDLLGGTVDYIGFSYYMSFAIDSHRENNPYFDYLETE
                     DLVKNNYVKASEWEWQIDPEGLRYALNWFTDHYHLPLFIVENGFGAIDQVAADGMVHD
                     DYRIEYLGAHIREMKKAVVEDGVDLMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDN
                     GKGSYNRSPKKSFGWYKEVISSNGESVE"
     gene            complement(2423..2761)
                     /locus_tag="VVR18_002173"
     CDS             complement(2423..2761)
                     /locus_tag="VVR18_002173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000176371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="HEU6033618.1"
                     /translation="MTLTIHVYYKGDGDSAIKFAREMLDSGLVEEIRNQKGNLKYEYF
                     LPIEKEGTILLIDQWINQEALDEHHQSKTMQKILDLRKKYHLQMQVERYIEDDSGMPE
                     SDKSFIDTGN"
     gene            complement(2917..>3158)
                     /locus_tag="VVR18_002174"
     CDS             complement(2917..>3158)
                     /locus_tag="VVR18_002174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033619.1"
                     /translation="LPTLTTPSVIIMDNARFHRMGKLELLCEEFGYKLLPLPPYSPEY
                     NPIEKTWAHIKKHLKKVLPSCNTFYEALLSCSCFN"
BASE COUNT         1040 a          647 c          412 g         1059 t
ORIGIN      
        1 ttatatcaaa ctcaaaacaa tttatcttaa cttaaatatt tattgacatt tcatgtgttc
       61 atcaaatatt ctcaagaatc aaattagcca ttttttcaat tcccattgga ataggaatat
      121 aggcttgagg aggtatttgt acaactggtt ttcctgcttt agaaccagcc tcttcaaatt
      181 gcttaaagta catttttgtt tgagggctga caagatacaa atcaaaagct gctgctgcga
      241 tagctttccc tccttcagta gcactaatag catcaactac aatatctttc ccttttcctt
      301 ttagaaactc tgttgttttc tgtgccataa gtgatgaaga cattcctgct gcacaaataa
      361 ttaaagcttt tgccataata ttttctcctt ttcttaaatc caatcaaagc tgtgctaagt
      421 tggcttattt gttatctatt tttattataa aataaagcgt ttccaatgac aattccctca
      481 ttttcctaaa tgatatggaa aaaaattatt tatacttcaa tttataaaat aaaattattc
      541 ctgagagtag aaatgaaaca ctatttgcta aaatcaaagg caagtctcct atacgaatac
      601 catgagcaag ccacaatgca ataccaataa cttgcataac atacatacct agagcaatag
      661 atcctgtgtc ctttgtctta actacacgaa aaacttgtgg taaaaatgca aatgttgtta
      721 aaattgctgc aatacttcca atcatatgtc acctcaatat gctaaacaaa ctgagaataa
      781 tctcagtttg tttatactat tctactgatt caccgttaga tgaaataact tccttatacc
      841 agccaaaaga ttttttcggg gaacgattat aacttccctt cccattgtca tctttatcta
      901 cataaataaa gccataacgt ttccgcattt caccggtacc agctgaaacc aaatcaatac
      961 atccccatgg agtataaccc attaaatcaa caccatcttc aactacagcc tttttcattt
     1021 cacgaatatg ggcacctaga tattcaattc tataatcatc atgtaccata ccatctgctg
     1081 caacttgatc tatagctcca aaaccatttt caacaataaa gagtggtaag tgatagtggt
     1141 ctgtaaacca atttaacgca taacgcaaac cttctggatc aatttgccac tcccattcag
     1201 aagccttaac ataattattt ttcactaaat cttccgtttc aagataatca aaataaggat
     1261 tattttcacg atgagagtcg atagcaaagg acatatagta actgaaacca atgtaatcta
     1321 cagtcccacc aagtaaatct tctttatcct gggcagtaaa atcaactgaa ataccttttc
     1381 gttcccaata cttgaaaata tgctcaggat atttacctaa aacatgcaca tcagcaaaat
     1441 aataacgctt ctgcatagct ttcattgcca ttaagatatc cttaggattg caagtagctg
     1501 gataaattgg acacatcgca atcatacaac ctatttgaaa atctggatta atctcatgac
     1561 caatttttac agctcgtgca gaagcaacta attcgtaatg tgctgcttga tacataattg
     1621 cctctctatt atcaccttcc tcatatacaa tacctgagtt agtaaatggt gcaaaatctt
     1681 ccttataatt cgcttgatta ttgatttcat tgaaagtcat ccaatattta accttatctt
     1741 tgtaacgttt aaatacgact tctgcaaaac gagcaaagaa atcaatcaat ttcctatttt
     1801 tccaaccacc atattcggtc actaagtgat aaggcatttc aaaatgagat agagtgatga
     1861 caggttcaat accattcttt aagcattcat caaaaagatt atcataaaac tgtaatcctt
     1921 cttcattcgg ctctaactca tcaccttttg gaaagatacg tgtccatgca atagaggtac
     1981 ggaagcactt gaatcccatt tcagcaaaaa gtgctatgtc ttctttataa cgatgataaa
     2041 aatctatcgc ctcatgattt ggataatatt taccctctaa aactcccgaa gtaatttcac
     2101 gagctactcc atggcgacca gcagtcataa catcagcaac actaattcct ttgccacctt
     2161 cttgccatcc accttcaagt tgatgagcag caacagcacc accccataaa aatccatctt
     2221 taaaagtagt catctttttt cctcctgact ttgatactct tattataaac ctcaaatcaa
     2281 aagatgaaaa cgcattcttt ttccttattg ttaaggaaag aagtaatttt taatggaaat
     2341 agaacaatat cttcttgtat tctcgtaatg atatctttac gattttcaat actttcaaac
     2401 tacaaaaact ctcacaataa ttctaattcc ctgtgtctat aaacgactta tcgctttctg
     2461 gcatcccaga atcatcttct atataacgtt caacttgcat ctgcaagtga tatttttttc
     2521 ttaaatctaa gattttctgc attgtctttg attgatgatg ttcatctaaa gcttcttgat
     2581 ttatccactg atcaataagg agaatagttc cctctttttc aattggtaaa aaatattcgt
     2641 atttcaagtt acctttttga tttctaattt cttcaacaag gccactatca agcatttctc
     2701 ttgcaaactt tattgcacta tctccatcac ctttataata tacatgaata gtcaatgtca
     2761 tcttatatcc tccaaaatca tccttcaatt ttaaaaaaac aagtttagat gaggatctaa
     2821 acttgttttt tatgaactaa ttatctaacg tttcgccatt actttcaatc acttctttat
     2881 accaataaaa tgattttttc ttatagcgat ttatagtcaa ttgaaacaag agcaggacaa
     2941 aagagcctca taaaaggtat tgcaacttgg taataccttt ttgaggtgct ttttgatatg
     3001 agcccatgtt ttctcaatag gattgtactc aggtgagtag ggaggaagtg gtaaaagttt
     3061 atacccaaac tcttcacaca agagttctag cttccccatt ctatggaatc ttgcattatc
     3121 cataataata accgatggtg tggttaatgt tggtaaga
//
LOCUS       DAVHSO010000108         3124 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.109, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000108 DAVHSO010000000
VERSION     DAVHSO010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3124)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3124)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3124
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.109"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            18..1043
                     /locus_tag="VVR18_002175"
     CDS             18..1043
                     /locus_tag="VVR18_002175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="HEU6033620.1"
                     /translation="MKNKFFLIAILAMCIVFSACSSNSVKNEENTSKEHAPDKIVLDH
                     AFGQTILDKKPERVATIAWGNHDVALALGIVPVGFSKANYGVSADKGVLPWTEEKIKE
                     LNGKANLFDDLDGLNFEAISNSKPDVILAGYSGITKEDYDTLSKIAPVAAYKSKPWQT
                     LWRDMIKIDSKALGMEKEGDELIKNTEARISKELEKHPEIKGKIKGKKVLFTMINAAD
                     TSKFWIYTSKDPRANYLTDLGLVFPESLKEFESEDSFAREISAEEANKINDADVIITY
                     GDDKTLEALQKDPLLGKINAIKNGAVAVIPDNTPLAASCTPTPLSINYTIEEYLNLLG
                     NACKNAK"
     gene            1033..2040
                     /locus_tag="VVR18_002176"
     CDS             1033..2040
                     /locus_tag="VVR18_002176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU6033621.1"
                     /translation="MRNKKQINLGIIFVICLGLLITIFLSLKLGTKEINIRDFLAAFG
                     MGNTNDDFIKSIIYKRIPRTIFAILAGSSLAISGVLMQSVTRNPIADPGILGINTGAS
                     LSVVIGLSFLGISSSISHISFAIIGGLVSAIFVYAIAVSGKAGLTPIKLALSGTCVSM
                     ALSSFVSFLILPNNNVLDKFRFWQIGSLGAATLSSISTLLPFIILGHLIAIFISSDLN
                     ALAMGDEMAVGLGVNVNRIRSLAIIASVLLCSSITAIGGPIGFVGLIVPHFCGLFISK
                     DIRTMTISSAFIGAELLLICDIIGRMLGKPGEIEVGIITAIIGGPVLIYVTMKNRGVN
                     N"
     gene            2040..3047
                     /locus_tag="VVR18_002177"
     CDS             2040..3047
                     /locus_tag="VVR18_002177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU6033622.1"
                     /translation="MQNLIIGIQKRKNRITLFSSLFLLIIISLSFFILLIGDESYSFS
                     TLIKVLNSETVPGASFSIMEIRLPKLLAGIIAGWSFGLAGFIFQTMLRNPLASPDIIG
                     VTSSSSIAAVFCILVLKTNSLTTGIISITCGLTSSLILFLLAKKDGFSAARLIILGIG
                     FQAVTRAGTSFLLLKVARYELQEVMRWLSGSLSFTKLDDIPLVLIVSIIATILVLFFN
                     KRLEIIELGEEIAIGLGANPELSRLVLIFCAVSLTAFSTSITGPIACISFLAGPIALN
                     IGKKRSPILAGLVGILLVLLSDIFSQNILPARYPVGVVTGLLGSPYLIYLLIKMNRRN
                     I"
BASE COUNT         1073 a          440 c          544 g         1067 t
ORIGIN      
        1 atgtttaagg agtttttatg aaaaacaaat tttttctaat agctatttta gctatgtgta
       61 tagtttttag cgcttgttct tctaattctg ttaaaaatga agaaaatact tctaaagagc
      121 atgcgcctga taaaatagtt ttagatcatg ctttcggtca aactatatta gataaaaaac
      181 ctgaaagagt tgcaactatt gcttggggaa atcatgatgt agcattagct ttaggaatag
      241 ttcctgttgg attttcaaaa gcaaattacg gtgtaagtgc tgataaagga gttttaccat
      301 ggacagaaga aaaaatcaaa gaactaaatg gtaaagctaa cctatttgac gatttggatg
      361 gacttaactt tgaagcaata tcaaattcta aaccagatgt tatcttagca ggttattctg
      421 gtataactaa agaagattat gacactctat caaaaattgc tcctgtagca gcatacaaat
      481 ctaaaccttg gcaaacttta tggagagata tgattaaaat tgattcaaaa gccttaggta
      541 tggaaaaaga aggtgatgag ttaatcaaaa atactgaagc tcgtatatcc aaagaattag
      601 aaaaacatcc agaaatcaaa ggaaaaatca aaggaaaaaa agtattattt actatgatta
      661 atgctgcaga tacatcaaaa ttctggattt atactagcaa agatccaaga gcaaattatt
      721 taacagattt aggtctagtt ttccctgaat cattaaaaga atttgagagt gaagatagtt
      781 ttgcaaggga aatttctgca gaagaagcaa ataagataaa tgatgctgat gtaatcataa
      841 cttatggtga tgataaaact cttgaagctt tacaaaaaga tcctctttta ggtaaaataa
      901 atgcaattaa aaatggtgcc gttgctgtaa ttccagataa tacaccgtta gcagcctcat
      961 gcactccaac accactttca ataaactata ctattgaaga atacctaaat cttttaggaa
     1021 atgcatgcaa aaatgcgaaa taaaaaacaa ataaacctag gcataatttt tgtaatctgc
     1081 ctaggtcttc ttattacaat atttttgtca ttaaagcttg gaacaaaaga aattaatatc
     1141 agagattttt tagcagcttt tggaatgggt aatacaaatg atgattttat taaatcaatt
     1201 atatataaaa gaatacctag aactattttt gcaattttag caggttctag tcttgccata
     1261 agcggtgtat tgatgcaatc agttactaga aacccaatag ctgatccagg tatactcggt
     1321 ataaacacag gagcaagtct tagtgtagta attggtcttt cttttttagg aatttcatca
     1381 agcataagcc atataagttt tgcaatcatt ggtggcttag taagtgcaat ttttgtatac
     1441 gcgattgctg taagcggaaa agcaggcctt acccctataa aacttgcctt atcaggaact
     1501 tgtgttagta tggctttaag cagttttgta agttttttaa ttttaccgaa taataacgtc
     1561 ttagacaaat ttagattttg gcaaataggt agccttggag cagctacatt atcttctata
     1621 tctacactac taccttttat aattttaggt cacttgatag ctatatttat ttcatcagat
     1681 ttaaacgctt tagctatggg tgatgaaatg gctgttggtc ttggagttaa tgttaatagg
     1741 ataagatcac ttgcaataat tgcaagtgtg cttttatgtt caagtattac tgcaattggt
     1801 ggacctattg gcttcgtagg tcttatagtt cctcactttt gtggcttatt tataagcaaa
     1861 gatatacgca caatgaccat ttcttcagct tttataggtg cagagctctt gcttatatgt
     1921 gatataatcg gccgtatgtt aggtaaacca ggtgaaattg aagtggggat aattactgca
     1981 ataatcgggg gtccagtact tatttatgta actatgaaaa atagaggggt taataactaa
     2041 tgcaaaattt aattataggt attcaaaaaa gaaaaaatag aataacacta ttttcctcac
     2101 tatttttatt aataataatc agtctatcat ttttcatttt acttatcgga gatgaaagtt
     2161 attctttttc aactttgatt aaagtcttaa atagtgaaac tgttcctgga gctagttttt
     2221 cgattatgga aattagatta ccaaaattat tagcaggaat tatagctggc tggtcttttg
     2281 gattggcagg atttatcttt caaactatgt taagaaatcc tcttgcaagt cctgatataa
     2341 tcggtgtcac aagttcttca tctattgcag cggtcttttg catattggta ttaaaaacaa
     2401 atagtttaac tactggaatt atttcaataa cttgtggact aacatcatct ttaatattat
     2461 ttttactagc taaaaaagat ggtttttcag cagcaagact gataatatta ggtattggtt
     2521 ttcaagctgt cacaagagca ggcacctcat ttttattgtt gaaagtagca agatatgaat
     2581 tacaagaagt tatgagatgg ctcagtggct ctttatcttt tacaaagtta gatgacatac
     2641 ctcttgttct aatagtaagt attattgcta ctatattagt tttatttttt aataaaagac
     2701 tagaaattat tgaacttggt gaagaaatag caatcggact tggagcaaat cccgagcttt
     2761 caaggcttgt tttaattttt tgcgctgtat ctttaactgc tttttctact tcaattacag
     2821 gaccaatagc ttgtatatct tttttagctg gtcccatagc cttaaatatt ggcaagaaaa
     2881 gaagcccaat attagctgga ttggttggaa ttttactagt tttgttatca gacatattct
     2941 ctcaaaatat tttaccagct agatatccag taggtgttgt aactggcttg ttaggttcac
     3001 catacttaat atacttacta ataaaaatga acaggagaaa tatataatga aaggtctgtg
     3061 gtcaaataat cttacctgcg gttatgatga aaaaataatc ttggaaaata taaatataaa
     3121 aata
//
LOCUS       DAVHSO010000109         2977 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.110, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000109 DAVHSO010000000
VERSION     DAVHSO010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2977)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.110"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..363
                     /locus_tag="VVR18_002178"
     CDS             <1..363
                     /locus_tag="VVR18_002178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033623.1"
                     /translation="VNMITELSEDEIDRIEAQEEKKYVVTFPKWILDKAEKDVRARNE
                     SNNSSVVYYIDSENRLASIDIDEVEPLELISLLENPDVKKMLKEEILKKMLDGYYSKL
                     PRHIIKDIINSYQEKNIQ"
     gene            complement(918..1319)
                     /locus_tag="VVR18_002179"
     CDS             complement(918..1319)
                     /locus_tag="VVR18_002179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEU6033624.1"
                     /translation="MLFFSISNDLLQLLISWEKQQRYELAKFGILSNPEQFVFTYIDT
                     KGNINKPLHADYLNNKMKSIRKRHKELTHATPHKLRHTGATLAKKAGMSLEAISKALT
                     HSDTGTTQIYVNTSNVVPMTVGEFALKSLKQ"
     gene            complement(1695..2903)
                     /locus_tag="VVR18_002180"
     CDS             complement(1695..2903)
                     /locus_tag="VVR18_002180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6033625.1"
                     /translation="MNYIKRPHYLDFLRRHRDRPIIKVVSGVRRAGKSVLFQLYKEEL
                     LATGVDEDQIISINFEDLSYYDLRHFQTLFAYIKDQLVSKKTYYIFLDEIQHVEKFEL
                     VADSLFILANVDLYLTGSNAYFMSSQLATNLTGRYVEIEVLPLSFEEYLSGQSLTENL
                     NTTEIFNNYLFSAFPYLLQTSSYAEKIDYLRGIYNSILLNDIVTRLGNPNPTIIERIV
                     RTLLSSTGSLISTNKIRNTLVSQNVSISHNTLENYLTTLTDSLLFYSVPRFDVKGRAL
                     LQRLEKYYPVDLGLRHLLLPDHKEDIGHILENMVYLELRRRYSQVYVGNLDKYEVDFV
                     VVTDLGHYAYYQVSETTLAPETLERELRPLEAIKDQFPKYLLTMDTIQPTANYNGIEK
                     KNIIDWLLEK"
BASE COUNT          987 a          437 c          518 g         1035 t
ORIGIN      
        1 gtaaacatga ttacagagtt atcagaagat gaaattgata ggatagaggc ccaggaagaa
       61 aagaagtatg ttgttacgtt tccaaaatgg attttagata aagcagaaaa agatgtgcga
      121 gcaagaaatg agtcaaataa ctcgagtgtt gtatattata ttgattcaga aaataggtta
      181 gctagcattg atattgatga agttgaaccg cttgaactca tatccctgct agagaatcct
      241 gatgtaaaaa aaatgttaaa agaagaaatt ttgaagaaaa tgttagatgg ttattacagt
      301 aaattaccaa gacatattat taaagacata ataaatagtt atcaagaaaa aaatattcaa
      361 tgaatttaat aataaaattt catcatttag ggcaaattac tgataaagct gactcgtttt
      421 ggttggtttt gtagaaaaat ttgccctatt tagatgaaaa tggttgaaat tagttgagaa
      481 ctagtaaata tttggtagtt aaaaatggtt tgattaaagg taattgaaag aacttagtta
      541 ttaggttagc caaaccaggt cttaagaaag ctcgtaaagc atcacaattt agtaagcgtt
      601 aattcgaaag aattactata cttatacaga gcacctttcg gggtgttctt tttttatact
      661 ttcttactaa attggtgtaa ttgacacagt tgttgcgact ttagtcgctt acaaatgtgg
      721 ctgcaacctg acaaggtcag ttgcctcaaa acgttaatca atacgattat atcaacgttt
      781 caaagcactc aaaagttcac cttattttta tagtaaaatg aaataagaat aggacaaatc
      841 gatcaggaca gtcaaatcga attctaacaa tgttttagaa gtagaggtgt actattctag
      901 tttcaatcta ctatacctta ttgttttaga gactttaaag caaattcacc tactgtcata
      961 ggaactacat tagaagtatt tacataaatc tgtgttgttc ctgtgtcact gtgtgttaga
     1021 gccttagaaa tggcttctaa gctcattcct gcttttttag caagtgtcgc tcctgtatgg
     1081 cgtaatttgt gaggtgtagc gtgtgtcagt tctttatgtc gctttctaat gcttttcatt
     1141 ttattgttca gatagtcggc atgtaaaggc ttgttgatgt ttccttttgt gtcgatatat
     1201 gtaaaaacaa attgttctgg attactgagg atgccaaact ttgctagttc atatctttgt
     1261 tgtttttccc aagagataag aagttgaagt aaatcattag aaatagagaa aaataggata
     1321 gcaaaagctc tatttcagga gaaaatgaag caaatatttc cataataaaa cgcatattat
     1381 caaggttgtt caatacctga tactatgcgc ttttctgatt ttaaagactg attgctcagt
     1441 ctctttttca ttataattca gttacaattt aatcttattt gagaaagtgg gtgatgctat
     1501 tctctaataa gactatgata ttaatttttg atagtacttc cagaaattat agatcccctt
     1561 tcatccccaa tttctatttt caagtgtccg tattatatag cgtattcgaa attcactata
     1621 tcttgttagg atttggggag aatcattggt aacagactgt tgcaaatcta attagctgta
     1681 tgatttatat ttatctattt ttctagtaac caatctataa tgtttttctt ctcgattcca
     1741 ttgtaattgg ctgttggctg aatcgtatcc attgttaata gatatttagg gaattgatct
     1801 ttaatggctt ctagtggtct aagttctctt tctagtgttt ctggagcaag tgttgtttca
     1861 ctgacctgat aataagcgta gtggccaaga tcagttacaa caacaaaatc aacctcatac
     1921 ttatctaaat taccaacata tacttgtgaa tatctacgtc tcaattccaa atataccata
     1981 ttttccaaga tatgcccaat gtcttctttg tggtctggta ataagagatg tcgtaaacct
     2041 aaatcaacgg gataatattt ttctaagcgt tgcaataatg ctctaccttt tacatcaaaa
     2101 cgtggaacgg aataaaaaag taaactatct gtcaaagttg tcaaataatt ttccaaagta
     2161 ttatgggata ttgaaacatt ttggctgact agggtattgc gaatcttatt tgttgatatt
     2221 aagctacctg tactactgag aagggttcgg acaatgcgct caataatagt aggatttgga
     2281 tttcccaatc tagtgacaat atcatttaac agtatggagt tatatattcc tctgagatag
     2341 tcaatttttt cagcgtaaga tgatgtttgc aataagtaag ggaaagcact aaagagataa
     2401 ttgttaaaaa tttctgttgt attcagattc tctgtgagag attgacctga tagatattct
     2461 tcaaatgaca aaggaagaac ctctatctca acataccgac cagtcaagtt tgttgctaat
     2521 tggctactca taaagtaggc gttagatcca gtcaaataga ggtctacatt tgctaagatg
     2581 aatagactat ctgctaccag ttcaaatttt tcaacatgtt gaatttcatc taaaaagata
     2641 tagtatgttt tcttgctaac taattgatct tttatataag cgaataatgt ttgaaaatgt
     2701 cgcagatcat agtaactcaa atcttcgaaa ttgatggata taatctgatc ctcgtctacc
     2761 ccagttgcta gtaactcctc tttatagagt tgaaaaagca cagatttacc agctcgtcta
     2821 actccactca caactttgat gattggtcgg tcacgatgtc ttcttaaaaa atctaaataa
     2881 tgtggtcttt tgatatagtt cataatagtt acctcaaaga tagtataata caaatagatg
     2941 ttattttcaa atatttagaa ataatattta atttgtt
//
LOCUS       DAVHSO010000110         2471 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.111, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000110 DAVHSO010000000
VERSION     DAVHSO010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2471)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.111"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..129
                     /locus_tag="VVR18_002181"
     CDS             <1..129
                     /locus_tag="VVR18_002181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HEU6033626.1"
                     /translation="LKINEGLTIGSVRSPLTPVTEEDRPVVEAAAALIRETKERFL"
     gene            156..350
                     /locus_tag="VVR18_002182"
                     /pseudo
     CDS             156..350
                     /locus_tag="VVR18_002182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398633.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
     gene            complement(500..1096)
                     /locus_tag="VVR18_002183"
     CDS             complement(500..1096)
                     /locus_tag="VVR18_002183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000547411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033627.1"
                     /translation="MHIHYNTNQTTLPLEISSFLPQDHLVFTIEKVVNTDEKEVNHLI
                     KYAMFDKEQKRGYKQSARNLANWHYNDKEDSYTHPDGWYYRFHHTKYQKTQTDFQQEI
                     KVYYADEPESAPQKGLYMNERYQNLKAKECQALLSPQGRQIFAQRKIDVEPVFGQIKA
                     SLGYKRCNLRGKRQVRIDMGLVLMANNLLKYNKRTTQN"
     gene            1369..2010
                     /locus_tag="VVR18_002184"
     CDS             1369..2010
                     /locus_tag="VVR18_002184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU6033628.1"
                     /translation="MTIESGQRIALVGQPGSGKSTLSKIPSGLYKIDTGKVLFDGVNI
                     NQIDKKILSQNLGVVPQDSFLLNRSILDNITLKHEVTSQKIEEVCKAVQIYDEIMAMP
                     MKFNTIISEMGSNISGGQRQRIALARALINNPSIVILDEATSALDTINEERITKYIKS
                     QGCTQIIVAHRLSTIKDADIIFVMKGGKIVESGNHKYLMELGGEYYSLYTKRK"
     gene            2023..2193
                     /locus_tag="VVR18_002185"
     CDS             2023..2193
                     /locus_tag="VVR18_002185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033629.1"
                     /translation="MKKENEYVILTTASLGVMIGIVFAIFLDFPVEYGISLGLLNGIV
                     LGSLIVYKNNKN"
BASE COUNT          794 a          388 c          482 g          807 t
ORIGIN      
        1 ttgaaaatca atgaaggctt gactattgga tctgttcgtt caccattgac accagtgact
       61 gaagaagatc gtccagttgt agaagcggct gcagccttga ttcgtgaaac caaggagcgc
      121 ttcctctaat ccataaggag gtatttatga cacactacgt tgtcaatcca gaggtggtca
      181 ttctcggggg tggtatcatg ggacaagaag ctatcctcaa accaaagatt cgtgcagcct
      241 tgaaagaagc cttggttcca agtttggctg agaacacaag attagaattt gctcatcatc
      301 aaaacactgc tggtatgctt ggagcctact atcattttaa aataaaataa atttaatatt
      361 tactttacta aattagtgta ttcttcctac tttaattaga gaatgattta agttctcttt
      421 aaaaatcaaa agagtctagg acaaaatagt tctcaatcac aaaaaagcta aagatttcca
      481 attgtggaac tctagctttt taattttgag tcgttctctt attgtatttt aggaggttat
      541 tggccataag taccaatccc atgtcaattc tcacttgacg cttgcctctc agattacatc
      601 tcttgtaacc caaagaagcc tttatctgcc caaagacagg ttccacatca atcttgcgtt
      661 gagcgaaaat ctgtctacct tggggagata aaagcgcctg acattcttta gctttcaagt
      721 tttgatagcg ttcgttcata tacagtccct tttgaggggc tgattcaggt tcgtcggcgt
      781 agtaaacctt gatttcttgt tgaaagtctg tctgtgtttt ctgatatttg gtatggtgaa
      841 aacgataata ccagccatca ggatgtgtat agctatcctc cttgtcatta tagtgccaat
      901 tcgctaagtt tctagctgac tgtttatagc ctctcttttg ttccttatca aacatggcat
      961 atttaatcag atggtttacc tccttttcat cggtattcac cactttttca atagtaaaga
     1021 cgagatggtc ttgcggcaag aaagaactga tttctagtgg taaagttgtt tgatttgtgt
     1081 tatagtgaat atgcatggga tagcctttct aaatggttta ttgggcaatt ctattttacc
     1141 aagactatcg caaccatgca aaaaagcaac ggcaaatccg cttctttttt ggagataaga
     1201 gactattgtc ccagactctt agtactggtt ggaggatacg atgaaagata gttattggtt
     1261 aaattatttt ccggagtata gtttagaaac gtttgaagta gaatagatat taaggaccta
     1321 tctttctctt attccaaaga ctcagctcct gtaatagaaa atttaaattt gactattgag
     1381 tcaggacaga gaattgcact agtcggtcaa ccggggtcag gaaaaagtac attatcaaaa
     1441 ataccatcag gattatataa gattgataca ggaaaagttt tatttgatgg tgtaaatatt
     1501 aatcaaatag ataaaaaaat attaagtcaa aatttaggag tagttccaca ggattcgttt
     1561 ttattgaacc gaagtattct tgataatata actttaaagc acgaagttac ttcacaaaag
     1621 atagaggaag tttgtaaagc agttcaaatc tatgatgaaa tcatggctat gccgatgaaa
     1681 tttaatacta taatctcaga gatgggttca aatatttcag gtggtcaaag acaacggata
     1741 gcactggcac gtgcattaat aaataatcct agtattgtaa ttttagatga agcaactagt
     1801 gctttagaca ctattaatga ggaaagaata acaaagtata taaaaagtca gggctgtact
     1861 caaataattg tagctcatag attgtcaacg attaaggatg cggatattat ttttgtaatg
     1921 aaaggtggta agattgttga gtcaggaaat cataagtact taatggagct tggtggagag
     1981 tactacagct tatatacaaa aaggaaatga ggtgtaaaga aaatgaagaa agaaaatgaa
     2041 tatgtaattt taacaacagc ctcactaggg gtgatgattg gaatagtgtt tgcaattttt
     2101 ttagattttc cagttgaata tggtatttct ttaggcttgt tgaatggaat agtattgggt
     2161 tcgctgattg tttacaaaaa caataagaat taagcataat tttttgctgt aaactaagga
     2221 gtagagatgg ctatagttgg aattataaat ctaacaaaaa gctttaaaga tattgaagtt
     2281 attcataaca cttaaataat agagcaatta cagtagtagc ttaaaaatat gattaaatcg
     2341 ctattcttag gagtagcggt ttttcttttt gtttaatact ctttgaaaat ctcttcaaac
     2401 cacgtcagct ttgccttgcc gtactcaagt acagcctgcg gctcgcttcc tagtttgctc
     2461 tttgattttc a
//
LOCUS       DAVHSO010000111         2420 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.112, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000111 DAVHSO010000000
VERSION     DAVHSO010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2420)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.112"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..527
                     /locus_tag="VVR18_002186"
     CDS             <1..527
                     /locus_tag="VVR18_002186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033630.1"
                     /translation="CGIAYGGIEIPLVAHLFKEKNEISFLFQNSHYSTQEVEVKRFRD
                     SRRNDSKSILLMDDNILTGRAMKNAAQKLSYRKYSVQFFHVRRLGLNRLSQVIQENSM
                     NELQRYLTGIYKGGIFPAPYSKIKFGTNIAKQYLDELQIFTLSGDEILRLLYKNGLFS
                     EESEVKVVRGNLYE"
     gene            524..1159
                     /locus_tag="VVR18_002187"
     CDS             524..1159
                     /locus_tag="VVR18_002187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000143825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloramphenicol acetyltransferase"
                     /protein_id="HEU6033631.1"
                     /translation="MTFPISEWKRNEEFDFFNKMDVPYLSMSSRIEVTQAINFHKKHS
                     ISLYAIISWCVMSAINSIPELLMDTDGKIVWQYNQRGCSFTTLTSEDKLNFSSFTMGD
                     NLIEFVSAFNINKQKAEEGQKPNIDKNNIAYLSCVPWIDFLHVSTPMNLSKIDTVPRI
                     TWGKVIQENQRYFCTVNLQINHGMGDGLHVSNFFVLLQRFVNKINEYFQKK"
     gene            1227..>2420
                     /locus_tag="VVR18_002188"
     CDS             1227..>2420
                     /locus_tag="VVR18_002188"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HEU6033632.1"
                     /translation="MSIFIGGAWPYANGSLHIGHAAALLPGDILARYYRQKGEEVLYV
                     SGSDCNGTPISIRAKKENKSVKEIADFYHKEFKETFEKLGFTYDLYSRTDSPLHHEIV
                     QELFLQLYEKKFLYTKKIKQLYCTFDNQFLPDRFVEGKCPNCGTHSRGDQCDNCSAIL
                     DPIDLVDKRCSICSNEPEVRETEHFYYVFSEFQNLLETYLNDAEETVRWRKNAINLTK
                     RYLREGLPDRAVTRDLPNGIPVPIDGFRDKKIYVWFEAVAGYYTASVDWAQKLQNNIT
                     DFWNNRTKSYYVHGKDNIPFHTIIWPAILSGLEIEPLPEYIISSEYLTLENKKISTSN
                     NWAIWLNDIIKKYDADSIRYFLTINAPEMKDANFSWREFIYSHNSELLGSYGNFINRT
                     LKFIEK"
BASE COUNT          878 a          321 c          447 g          774 t
ORIGIN      
        1 tttgtgggat agcttatggc gggatagaaa ttcccttggt tgcgcaccta tttaaagaaa
       61 aaaatgaaat atcattttta tttcaaaata gtcactacag tactcaagaa gttgaagtaa
      121 aaaggttcag ggacagtcgg agaaatgatt cgaaaagtat cttattaatg gatgataata
      181 ttttgacagg aagggctatg aaaaatgctg ctcagaaatt atcataccga aaatattcag
      241 tccaattctt tcatgtcagg aggcttggcc taaatagatt atcacaagtt attcaagaaa
      301 attcaatgaa tgaattgcag aggtatttaa caggaatata taaaggaggg atttttcctg
      361 caccgtattc aaaaattaaa ttcggtacta atattgctaa acaatattta gatgaattac
      421 aaatttttac tctatctgga gatgaaatct taagactact ttataagaat ggcttgttct
      481 cagaagagag tgaagtgaaa gtggtaaggg ggaatttata cgaatgacat ttcctatatc
      541 agagtggaaa aggaatgaag aatttgactt tttcaataaa atggatgttc cttatttatc
      601 tatgagttca cgaatagaag taacgcaggc tatcaatttt cataaaaaac attcgatatc
      661 actttatgcc ataatatcgt ggtgtgttat gagtgcaata aattctattc cagaattact
      721 aatggatacc gacggaaaga ttgtctggca atacaatcaa agaggttgtt ctttcactac
      781 ccttacatcg gaagataagc ttaatttttc ttcatttacg atgggagata atttaattga
      841 atttgtttct gcgttcaaca taaataaaca gaaggcagaa gaagggcaaa aaccaaatat
      901 tgacaagaat aacattgctt atctttcttg tgttccatgg attgattttt tacatgtaag
      961 cactcctatg aatctttcaa aaattgatac agttcctcga ataacgtggg gaaaagttat
     1021 tcaagagaac caaagatatt tttgtacagt gaatttacaa attaatcatg gaatgggaga
     1081 tggattacac gtatctaatt tttttgtgtt attgcaaagg tttgtaaata aaataaatga
     1141 atattttcaa aaaaagtaat gattgaaaag atattgcatt taaataatgt tataataaaa
     1201 ataaagaatt taaggagaaa tacaatatgt caatttttat tggaggagca tggccatatg
     1261 caaacggttc gttacatatt ggtcacgcgg cagcgctttt accgggggat attcttgcaa
     1321 gatactatcg tcagaaggga gaggaagttt tatatgtttc tggaagtgat tgtaatggaa
     1381 cccctatttc tatcagagct aaaaaagaaa ataagtctgt gaaagaaatt gctgattttt
     1441 atcataagga atttaaagaa acttttgaaa aattaggttt tacatatgac ttgtactcgc
     1501 gaacagattc tccactacat catgagatag tacaagaatt atttttgcaa ttatacgaga
     1561 agaaattttt gtatacaaaa aaaattaaac aactctattg tacatttgat aatcaattct
     1621 tacctgatag gttcgttgaa ggaaaatgcc cgaattgtgg aacccattca agaggagatc
     1681 aatgtgataa ttgctcagca attttagatc ctatagattt agttgataaa agatgttcta
     1741 tttgttccaa tgaaccagaa gttcgtgaga cagaacactt ttattatgtt tttagtgagt
     1801 ttcaaaattt gttagagact tacttaaatg atgctgaaga aacagtgaga tggcgaaaaa
     1861 atgcaataaa tctaactaaa aggtatttac gggaaggttt acctgatcga gctgttactc
     1921 gtgatctacc aaatgggatt ccagttccca ttgatggttt tagagataaa aaaatatatg
     1981 tctggtttga agcggtagca ggttactaca cagcaagtgt tgattgggcg caaaaacttc
     2041 aaaataatat tactgatttt tggaacaatc ggacaaagtc atattatgtt catggaaaag
     2101 ataacatccc atttcatact attatttggc cggcaatact ctcaggttta gaaatagagc
     2161 ctcttccaga gtatattatt tctagtgaat atttaacgtt agaaaacaaa aaaatatcaa
     2221 caagtaataa ttgggctata tggcttaacg atatcataaa aaaatatgat gctgattcaa
     2281 tccgatactt cctaacaata aatgctcctg agatgaaaga tgcaaatttt tcttggagag
     2341 aatttattta tagtcataac tcagaattat taggatcgta cggtaatttt atcaatagga
     2401 ctctaaagtt tattgaaaag
//
LOCUS       DAVHSO010000112         2367 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.113, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000112 DAVHSO010000000
VERSION     DAVHSO010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2367)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.113"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(370..762)
                     /locus_tag="VVR18_002189"
     CDS             complement(370..762)
                     /locus_tag="VVR18_002189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEU6033633.1"
                     /translation="MELDKFKTMMNVRKRMTYFLRFQRMAGSENQVRIDEEAWKLVLP
                     DQWHLSGEHEKAIREGLEIFAHDINSIENERARKYFIIHYCYMRKKTMSECVEMAGTS
                     STSYHRYKQISVLNFARIHQNGELEAYK"
     gene            complement(799..1056)
                     /locus_tag="VVR18_002190"
     CDS             complement(799..1056)
                     /locus_tag="VVR18_002190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033634.1"
                     /translation="MKKARLDSEILEELLENNKVNYLDANQYAIEIGEILAKVLGAYL
                     SNINQEDVERRKQIGIESAEERKRKRDERIAKFGNPRRRLS"
     gene            complement(1065..2363)
                     /locus_tag="VVR18_002191"
     CDS             complement(1065..2363)
                     /locus_tag="VVR18_002191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000172765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033635.1"
                     /translation="MTLKGMGYLRKKLANYKMGVDTRYNQYAMKHNDIDVGITIPPQI
                     RQQYRAVLGWAAKGVDSLADRLVFREFANDEFGANEIFAQNNPDVFFDSAILSALIGS
                     CCFVYISQGDDDDAPRLQVIEASNATGVLDPITGLLIEGYAVLKRDDNGYAVLEAYFT
                     SDVTWFYPKDGKPFAIENPTGVPLLVPVIHRPDAVRPFGRSRITKAGMYYQRYAKRTL
                     VRSDVTAEFYSFPQKYVLGLSQDAEAIDTWKATVSSLLTFTKDDEGEKPNVGQFTTSS
                     MSPFTEQLRTAAAGFSGEMGLTLDDLGFVSDNPSSVEAIKASHENLRLAGRKAQRSLG
                     SGLLNVAYVATCLRDEFPYLRKQFNKTVVKWEPLFEADANMLTLIGDGVIKLNQAVPG
                     YMDAETIRDLTGIKGSDKPAPVVKEGADGGRYVSESTPEN"
BASE COUNT          670 a          601 c          405 g          691 t
ORIGIN      
        1 tttgacttag gcatcatttc acacctcaat atagcgccta aacccttgat attactgact
       61 ttttgaaaaa tctcatttga ttagaaatca ttaaaagttc ttaaaaattc tcaaaaagtc
      121 cacaaaaaaa agccccacaa aagggcaata aatgacgagt tcagcaggca agaaactagc
      181 acggtcaaac gtgctttttt attgctgatt gctgataggt atattatacc atgaagcgcg
      241 tagtttataa gattatgacc tcacaaaagc cccccagatt cgtttctaag ggcttctagt
      301 ttatctatgg tgttttagtt gtccagtacg aaacaaagcg aaataagggg gcgaatatgc
      361 agcctcagcc tacttatatg cttctagctc tccgttctgg tggattcttg caaagtttaa
      421 gacggatatc tgtttgtatc ggtggtagct agtggagcta gtacctgcca tttctacgca
      481 ttcgctcata gttttctttc tcatatagca ataatggata atgaagtatt ttctggctct
      541 ctcgttctct atgctgttga tgtcgtgggc gaatatctcc aacccctcac ggattgcttt
      601 ttcatgctca ccgctcaaat gccactgatc aggtaagaca agtttccaag cctcttcatc
      661 tatcctaact tggttttcac tacctgccat cctctgaaat ctcagaaagt aagtcatccg
      721 ctttctgacg ttcatcatcg ttttaaactt atccagctcc atttttaacg acaacctttc
      781 tactcctgta acttatgcct agcttaatct tcttctagga tttccaaact tggcaatcct
      841 ttcatctcgt tttcttttac gttcttcagc agactctata cctatctgtt ttcgacgctc
      901 cacatcttct tgattgatat tactcaagta agctcctaag acctttgcga gtatttcacc
      961 aatttctata gcatattgat tggcgtccag ataattaact ttattgtttt ctagtaactc
     1021 ttccagaatc tcactatcaa gcctagcttt tttcaaattc gtccttaatt ttctggagta
     1081 gactcggaaa catatcttcc accatctgca ccctccttca ctactggagc aggcttgtct
     1141 gaccccttaa ttccagtcaa gtcacggatg gtttcagcat ccatatagcc aggcaccgct
     1201 tgattcagtt tgataacacc atcaccaatc aaggtcaaca tattagcgtc tgcctcaaac
     1261 aaaggctccc acttcacgac cgttttattg aactgtttcc tcaaatacgg aaactcatct
     1321 cgtaaacaag tagcgacata ggccacattc agcagaccag aacccagaga gcgctgagcc
     1381 ttccgaccag ctaaacgcaa gttctcatga ctagccttga tggcttcaac ggatgatgga
     1441 ttgtcagaaa caaaaccaag atcatccaag gtcaatccca tttccccaga aaatccagct
     1501 gctgcagtcc gtaactgctc agtaaaagga gacatgctgg acgtggtgaa ttgtcccaca
     1561 ttcggctttt ccccttcatc atctttggta aaagtcagca agctagatac agttgctttc
     1621 caagtatcaa tcgcctcagc atcttgactc aatcccaaca catacttctg agggaatgaa
     1681 tagaactcag cagtaacatc tgaccgcaca agcgttcgtt tagcatatct ctgatagtac
     1741 atcccagcct tagtaattcg tgaccgacca aacggccgaa cagcatcagg cctatgaatg
     1801 actggcacca gcaaaggaac acccgtcgga ttttcgattg caaacggctt accatctttc
     1861 ggatagaacc aagtcacatc actagtaaaa taagcctcaa gcacggcata accattgtca
     1921 tcccttttca aaacggcata gccctctatc aacaagccag tgataggatc cagaacacca
     1981 gttgcattac ttgcctcgat aacctgcaac cgaggagcgt catcatcgtc cccttgcgag
     2041 atgtagacaa aacaacacga cccaatcaat gccgaaagaa tcgcgctatc aaagaataca
     2101 tctggattgt tctgagcaaa gatttcattc gctccaaatt cgtcattggc aaactcacga
     2161 aagaccaaac gatctgctag actgtcaaca cccttagcag cccaacctaa gaccgcccga
     2221 tattgttgcc tgatttgagg tggtatcgta ataccaacat ctatgtcatt gtgtttcata
     2281 gcatactgat tgtatctagt atctacaccc attttataat tggctagctt cttcctgaga
     2341 tagcccatac ctttcaatgt catttta
//
LOCUS       DAVHSO010000113         2362 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.114, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000113 DAVHSO010000000
VERSION     DAVHSO010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2362)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.114"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            239..2221
                     /locus_tag="VVR18_002192"
     CDS             239..2221
                     /locus_tag="VVR18_002192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU6033636.1"
                     /translation="MKSSRLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETDP
                     DNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKDA
                     KWYTSEGEEYAAVKAQDFVTGLKYAADKKSDALYLVQESIKGLDAYVKGEIKDFSQVG
                     IKALDEQTVQYTLNKPESFWNSKTTMGVLAPVNEEFLNSKGDDFAKATDPSSLLYNGP
                     YLLKSIVTKSSVEFAKNPNYWDKDNVHIDKVKLSFWDGQDTSKPAENFKDGSLTAARL
                     YPTSASFAELEKSMKDNIVYTQQDSITYLVGTNIDRQSYKYTSKTSDEQKASTKKALL
                     NKDFRQAIAFGFDRTAYASQLNGQTGASKILRNIFVPPTFVQADGKNFGDMVKEKLVT
                     YGDEWKDVNLADSQDGLYNPEKAKAEFAKAKSALQAEGVTFPIHLDMPVDQTATTKVQ
                     RVQSMKQSLEATLGADNVVIDIQQLQKDEVNNITYFAENAAGEDWDLSDNVGWGPDFA
                     DPSTYLDIIKPSVGESTKTYLGFDSGEDNVAAKKVGLYDYEKLVTEAGDETTDVAKRY
                     DKYAAAQAWLTDSALIIPTTSRTGRPILSKMVPFTIPFALSGNKGTSEPVLYKYLELQ
                     DKAVTVDEYQKAQEKWMKEKEESNKKAQEDLAKHVK"
BASE COUNT          803 a          404 c          499 g          656 t
ORIGIN      
        1 ccataaaggg gaaactcttt tttgtttagt aaaaaacacc cattgggtga aaaaagaaac
       61 catccaggat ctaagctaag gcaaggattc tggatggttt ttagattagg ggtgaataat
      121 tggggatatt ttttgcaaag atgttgtttg aaaaataatt ttcaaaaatt ctgaaaattc
      181 tgttgacaac tttctgaaaa gagtctataa tggagagaaa gttttaaagg agaaaatgat
      241 gaaaagttca agactatttg cccttgcggg cgtgacatta ttggcggcga ctactttagc
      301 tgcatgctct ggatcaggtt caagcactaa aggtgagaag acattctcat acatttatga
      361 gacagaccct gataacctca actatttgac aactgctaag gctgcgacag caaatattac
      421 cagtaacgtg gttgatggtt tgctagaaaa tgatcgctac gggaactttg tgccgtctat
      481 ggctgaggat tggtctgtat ccaaggatgg attgacttac acttatacta tccgtaagga
      541 tgcaaaatgg tatacttctg aaggtgaaga atacgcggca gtcaaagctc aagactttgt
      601 aacaggacta aaatatgctg ctgataaaaa atcagatgct ctttaccttg ttcaagaatc
      661 aatcaaaggg ttggatgcct atgtaaaagg ggaaatcaaa gatttctcac aagtaggaat
      721 taaggctctg gatgaacaga cagttcagta cactttgaac aaaccagaaa gcttctggaa
      781 ttctaagaca accatgggtg tgcttgcgcc agttaatgaa gagtttttga attcaaaagg
      841 ggatgatttt gccaaagcta cggatccaag tagtctcttg tataacggtc cttatttgtt
      901 gaaatccatt gtgaccaaat cttctgttga atttgcgaaa aatccgaact actgggataa
      961 ggacaatgtg catattgaca aagttaaatt gtcattctgg gatggtcaag ataccagcaa
     1021 acctgcagaa aactttaaag atggtagcct tacagcagct cgtctctatc caacaagtgc
     1081 aagtttcgca gagcttgaga agagtatgaa ggacaatatt gtctatactc aacaagactc
     1141 tattacgtat ctagttggta caaatattga ccgtcagtcc tataaataca catctaagac
     1201 cagcgacgaa caaaaggcat cgactaaaaa ggctctctta aacaaggatt tccgtcaggc
     1261 tattgccttt ggttttgatc gtacagccta tgcctctcag ttgaatggac aaactggagc
     1321 aagcaaaatc ttacgtaata tctttgttcc accaacattt gttcaagcag atggtaaaaa
     1381 ctttggcgat atggtcaaag agaaattggt tacttatggg gatgaatgga aggatgttaa
     1441 tcttgcagat tctcaggatg gtctttacaa tccagaaaaa gccaaggctg aatttgctaa
     1501 agctaaatca gccttacaag cagaaggtgt gacattccca attcatttgg atatgccagt
     1561 tgaccaaaca gcaactacaa aagttcagcg cgtccaatct atgaaacaat ccttggaagc
     1621 aactttagga gcggataatg tagtcattga tattcaacaa ctacaaaaag acgaagtaaa
     1681 caatattaca tattttgctg aaaatgctgc tggcgaagac tgggatttat cagataatgt
     1741 cggttggggt ccagactttg ccgatccatc aacctacctt gatatcatca aaccatctgt
     1801 aggagaaagt actaaaacat atttagggtt tgactcaggg gaagataatg tagctgctaa
     1861 aaaagtaggt ctatatgact acgaaaaatt ggttactgag gctggtgatg agactacaga
     1921 tgttgctaaa cgctatgata aatacgctgc agcccaagct tggttgacag atagtgcttt
     1981 gattattcca actacatctc gtacagggcg tccaatcttg tctaagatgg taccatttac
     2041 aataccattt gcattgtcag gaaataaagg tacaagtgaa ccagtcttgt ataaatactt
     2101 ggaacttcaa gacaaggcag tcactgtaga tgaatatcaa aaagctcagg aaaaatggat
     2161 gaaagaaaaa gaagagtcta ataaaaaggc tcaagaagat ctcgcaaaac atgtgaaata
     2221 actgttgcaa aatataagaa aggatttagt atttctcttg aatgctgaat ccttttttac
     2281 atttgtaaag aaagattcta aatgtactga cccccaaaag ttggagcctc tttttgtcag
     2341 aatagagaaa atttttgtta at
//
LOCUS       DAVHSO010000114         2204 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.115, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000114 DAVHSO010000000
VERSION     DAVHSO010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2204)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.115"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            417..1100
                     /locus_tag="VVR18_002193"
     CDS             417..1100
                     /locus_tag="VVR18_002193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU6033637.1"
                     /translation="MKEKKVYQILAIDDDESILRLIKNSLERSEFEVTTRREVGNIDI
                     CSFIGFDLILLDIMMSIDGLEICKSIREQIDVPIIFVTAKQLDSDLASGVKAGADDYI
                     KKPFSITELVARVRMHIQREERNRKNNKEICTKNLIINVSNQEILIEEETISLTKREF
                     TILYTLASNPKRVYSVEELYERIYPSESDAQFRSIAEYIYQIRSKLKPYSINPIKTQW
                     GGGYSWNEN"
     gene            1085..2182
                     /locus_tag="VVR18_002194"
     CDS             1085..2182
                     /locus_tag="VVR18_002194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003093784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEU6033638.1"
                     /translation="MERKLDFKTLVKKTKWTIVKQFCLNIIVAYIFPISTISIDIHSE
                     TQSIARDLLGVLFNVFSWVYICISLIIIVSINIKALLTRVKQEMEIVYHSSIWLTSVN
                     DSSNLTILEFIETNRHIESMQQRIKNMIQVEKDQKADILFKVSAMAHDLKTPLTVIKG
                     NSELLQLAPLSGIDVQCLKDIERASNQLNSYFNQLINYSKTFYSDQISFHQYRISNLS
                     KILEQECTYLIGDSIDYKYSTKIDRDCNIELDLDLIIRSVANIVNNAIAYADDAKKKI
                     RVTFELADSNITLSIWNNGSKFSDDVLENFGKLFYREDTSRNSQFEHFGIGLAFVKQV
                     MSIHSGDIQLQNKENGAMVKLIIPMKSSDYV"
BASE COUNT          760 a          273 c          398 g          773 t
ORIGIN      
        1 ggactctggt tgctttctgt actatttgcg tagtgtatat tttttatggt ctattaattc
       61 ccttacttat ttataccttt acattaagaa taatattggt atcaattggt ttaatattaa
      121 tatgttttag tttagtgatt ataacaagga gtatagttgt tccaatgggg atgtctttgt
      181 cttttttgtt ggggttgggt caaatgcttc tgcaattcag cgatgctttt ctctacttcc
      241 caattatctc cactatgaat tcatttttga tgactgagaa tcaatcttat ataccttata
      301 caataggtat tgcaattcaa tttttatggg ggattttgtt gttatctttc tctattttgc
      361 tattttggaa gagaatagta cgataaaaat tttgtatttt gtgatattat ataattatga
      421 aagaaaaaaa agtatatcaa atattagcaa ttgatgatga tgaaagcatt cttcgtttga
      481 taaagaattc tttagaacgc tcggagtttg aagttacgac gaggagagaa gtaggtaaca
      541 tagatatttg ttcattcatt ggctttgatt taattttatt agatattatg atgtcgattg
      601 atggtttaga aatttgtaaa tccattcgag aacaaatcga tgtaccgata atttttgtaa
      661 cagccaagca attggatagt gacttggcta gtggagtaaa agctggtgcg gatgattata
      721 taaaaaaacc atttagtatt acagaattag ttgctcgtgt taggatgcat atccaaaggg
      781 aggaaagaaa tcgtaaaaat aataaagaaa tatgcacaaa gaatttgata attaatgtca
      841 gcaatcaaga aatcttaatt gaagaagaga ctatatcatt gacaaagcga gaatttacaa
      901 ttttatatac tttagcaagc aacccgaaga gagtatattc cgtagaggag ctctatgaga
      961 gaatatatcc gtcggaatca gatgcacaat ttcgttctat tgctgagtat atttatcaaa
     1021 ttcgttcaaa attaaaacca tattcaatta atccgatcaa gacacagtgg ggaggcggat
     1081 atagttggaa cgaaaattag attttaagac tttagtaaaa aagacgaagt ggacgattgt
     1141 taaacaattt tgtttgaata taattgtagc ttatattttt cctatatcaa ctatttctat
     1201 tgatattcat tcagaaactc agtcaatcgc tcgtgacttg ttaggggtat tatttaatgt
     1261 tttttcatgg gtttatattt gtatatcttt gattattata gtttctatta atattaaagc
     1321 cttgttgaca agagtaaagc aagaaatgga gattgtttat catagcagta tatggctaac
     1381 ctctgtaaac gattcatcta atttaacaat tcttgaattc atagagacaa atagacacat
     1441 tgaatcaatg caacaaagaa taaaaaatat gattcaggta gagaaagacc aaaaggcgga
     1501 tattctcttt aaagtttcag cgatggcaca tgacttaaaa acacctttga ctgtgattaa
     1561 aggaaactcg gaattgttgc aattggcacc tttatcaggt attgatgttc aatgtctcaa
     1621 ggatattgaa agagcaagta accaattaaa tagctatttt aatcagttaa tcaactactc
     1681 taaaactttt tactctgatc agatttcttt tcatcagtat cgtatcagta atttatccaa
     1741 aatactggaa caagagtgta cataccttat tggagatagc attgactaca aatatagtac
     1801 taagatagac cgagactgta atattgaatt ggatttagat ttaattatcc gttcggtggc
     1861 aaatattgtt aataatgcta tagcttatgc agatgatgct aaaaagaaaa tcagagttac
     1921 ctttgagtta gcagatagca atattacctt aagtatttgg aataatggtt ccaaattttc
     1981 ggatgatgtt ttagaaaatt ttggaaaatt attttatcga gaagatacta gcagaaattc
     2041 acaatttgaa cattttggaa taggtttggc atttgtaaaa caagtaatga gcattcattc
     2101 aggtgatata caattgcaaa ataaggaaaa tggagctatg gttaaattaa ttattccgat
     2161 gaaaagtagt gactatgtct aggcttgaat atcgtaattt tgaa
//
LOCUS       DAVHSO010000115         2198 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.116, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000115 DAVHSO010000000
VERSION     DAVHSO010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2198)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2198)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.116"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..357
                     /locus_tag="VVR18_002195"
     CDS             <1..357
                     /locus_tag="VVR18_002195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033639.1"
                     /translation="LLLVNLFFSLSLWLFTDSVLFVVAMSILMTCYGAGFSLIPAYLS
                     DIFGTKELAALHGYILTAWAMAGLAGPILLAETYKMAHSYTQTLFVFLILYSIALALS
                     YYLGRSIKKESQKPLT"
     gene            556..2130
                     /locus_tag="VVR18_002196"
     CDS             556..2130
                     /locus_tag="VVR18_002196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU6033640.1"
                     /translation="MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQ
                     AQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRS
                     VYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQNIETLILDEADEMLNMGF
                     LEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYY
                     IRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQN
                     KRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAG
                     KSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADE
                     TIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGN
                     GFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNT
                     LSEKQTGFVIRNKGDK"
BASE COUNT          660 a          427 c          479 g          632 t
ORIGIN      
        1 ttactgcttg tcaatctttt cttttctctc tcactttggc tctttacaga ttccgtttta
       61 tttgtagttg ctatgtctat tttgatgact tgctatggag ctggtttttc tttgattcca
      121 gcttatctca gtgatatttt tggaaccaag gaattggccg ctctgcatgg ttatatttta
      181 acagcttggg caatggctgg tttagcggga cctattttat tagcagagac ttataaaatg
      241 gctcattcgt acacacaaac cttgttcgtt tttctcattt tatacagtat cgccttggct
      301 ttgtcttatt atctaggtcg ttcaatcaaa aaagaaagtc aaaaaccgct tacatgattt
      361 tctgtagaaa tggggctatc ttttgctctg gtcttgtgtt atactagata ggttgcaaag
      421 aaaacagtac ttttcttttg tggaaaagaa gcaacacgat tttatatcta gttatatgaa
      481 aatacgtcat aaaaagaaaa gtataaacta agccctatag ggtggcttcg caccaccttt
      541 agaaagaaga ataacgtgaa atttaatgaa ttaaacttgt ctgctgattt gctagcagaa
      601 attgaaaaag ctggttttgt agaagctagt cctatccaag aacaaactat tcctttggcc
      661 cttgaaggca aggatgttat cggtcaagct cagactggta caggaaaaac tgcagccttt
      721 ggcttgccta cccttgaaaa aatccgtaca gaagaagcga ctatccaagc cttggtcatc
      781 gctccaactc gtgaactagc tgtccaaagt caagaagaac tcttccgctt tggtcgtagt
      841 aagggagtca aagtccgttc agtatatggc ggatcaagca ttgaaaaaca aattaaggct
      901 cttaaatctg gtgcccatat cgtggtggga actccaggtc gcctcttgga cttgattaaa
      961 cgcaaggcct tgaaattaca aaacattgaa acccttatcc ttgacgaagc ggatgaaatg
     1021 cttaacatgg gcttccttga agacatcgaa gccattattt cccgtgtacc tgagaaccgt
     1081 caaactttgc ttttctcagc aactatgcca gatgccatca aacgtatcgg tgttcagttt
     1141 atgaaagccc ctgaacatgt caagattgcg gctaaggaat tgacaacaga attggttgac
     1201 cagtactata tccgtgttaa ggaacaagaa aaatttgaca ccatgactcg tctcatggat
     1261 gtggcacaac cagaactcgc tattgtattt ggtcgtacca aacgccgtgt ggatgaattg
     1321 actcgtggtt tgaaaattcg tggcttccgt gcagaaggaa ttcatggcga cctagaccaa
     1381 aacaaacgtc ttcgtgtcct tcgtgacttt aaaaatggca atcttgatgt tttggttgcg
     1441 acagacgttg cagcgcgtgg tttggatatt tcaggtgtga cccatgtcta caactacgat
     1501 attccacaag atcctgagag ttatgttcac cgtatcggtc gtacaggtcg tgctggtaag
     1561 tcaggtcaat ctattacttt tgttgctcca aacgaaatgg gttaccttca aatcattgaa
     1621 aacttgacta agaaacgcat gaaaggtctc aaacctgcaa gtgtagaaga atccttccaa
     1681 tcaaaaaaac aggtggctct caagaaaatc gaacgtgatt ttgcagatga aaccattcgt
     1741 gccaactttg agaaatttgg taaggatgct cgcaaattgg ctgctgagtt tactccagaa
     1801 gaattggcaa tgtatatctt gagtctgaca gtccaagacc cagatagcct tccagaagtg
     1861 gagattgcac gtgaaaaacc actaccgttt aaaccatcag gtaatggttt cggtggtaaa
     1921 gctaagggag gtcgtggagg ccgtcgtggg gacgaccgtc gagagcgtga tcgccgtggc
     1981 aatggtcgcc gtgatgagtt caaaaaagga agtcgtggca acgatcgttt tgataaggaa
     2041 aaacgttacc gtaaggataa taaaaaacca cgcaatactt taagcgaaaa gcaaacaggc
     2101 tttgttattc gtaacaaagg cgataaataa gaaaaagcgg ttcaaaatga atcgcttttt
     2161 tatataagga gaccgaatgt gaaaagacaa ataaaatt
//
LOCUS       DAVHSO010000116         2183 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.117, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000116 DAVHSO010000000
VERSION     DAVHSO010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2183)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.117"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..454)
                     /locus_tag="VVR18_002197"
     CDS             complement(<1..454)
                     /locus_tag="VVR18_002197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033641.1"
                     /translation="MTIEEYNEAVNYEFTSDTCQLANSIYQSLFKFFDKKNFSGDLIF
                     TWKSPSLVKEGDYIGRRDSQVDNLRVIGNIFPNYLTNRKYSLNMNRNGCMGDFPHDFF
                     DIYLDHVAKYAYEQKVNNIKEYYPLKRAILHQENALYFRLFSNFDDFLE"
     gene            complement(488..1201)
                     /locus_tag="VVR18_002198"
     CDS             complement(488..1201)
                     /locus_tag="VVR18_002198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HEU6033642.1"
                     /translation="MSYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYY
                     VPMNKALWKDLELKKISKQELVNTRFSRLFAHFGQEKDGSFLAQRYQFYLAQQGQTLS
                     GAHDLLDSLIERDYDLYAATNGITAIQTERLAQSGLAPYFNQVFISEQLQTQKPDALF
                     YEKIGQQIAGFSKEKTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVY
                     SYQDLLDCLDKNILEKITF"
     gene            complement(1262..2077)
                     /locus_tag="VVR18_002199"
     CDS             complement(1262..2077)
                     /locus_tag="VVR18_002199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FRG domain-containing protein"
                     /protein_id="HEU6033643.1"
                     /translation="MIPGIWREAYSVSDSRGERIPIHRTNFYNPKGEVVVMPSQNVLL
                     EKFMSKAMTEDILGPKNEVQWLELAQHYGLPTNLLDWSTDPLVALFFAASTVDCKNDN
                     ETYLTEDQVIVREDDEDEDEIIHAHASVWVINPLEINQILLNEPGIEGVFQSFNPNDI
                     EKINKEISLNCGTFCFEGSKINPRITRQSGNFTHSGTKLTHPLDFLAAVQSKIIKINI
                     PYSCISKIITDLNKLDITNESIYFGRTERDLTAERIKGEVYSEFKEYLNSIIE"
BASE COUNT          682 a          390 c          375 g          736 t
ORIGIN      
        1 tttctaaaaa gtcgtcaaaa ttagaaaaca atcgaaaata caatgcattc tcttggtgta
       61 aaatcgctct ttttaaagga taatactctt taatattatt aactttttgt tcgtaggcat
      121 attttgctac atgatctagg tatatatcaa aaaagtcatg aggaaaatct cccatacagc
      181 cattacgatt catattgagg ctatattttc gattagtaag ataattcgga aatatatttc
      241 ctattactct aagattatct acttgtgaat cccttctccc aatataatcc ccttctttga
      301 ctaatgatgg agatttccaa gtaaaaatta aatcgccaga gaaatttttc ttatcaaaaa
      361 acttaaaaag agattgataa atactatttg ctaattgaca agtgtcagat gtaaattcat
      421 aattaacagc ttcattgtac tcttcaatag taatattagc ttttttgtag tcattagctc
      481 gtctccttta aaatgtgatc ttttcaagaa tatttttatc taaacaatcc agcaagtctt
      541 ggtaagaata gacttcgtaa gtcggctggg cttgtgtgtg attttcgagg tgatgaggat
      601 tataccagat agtgtcaatc cccgcattat tgccaccttg aatgtcggcg gttagagaat
      661 ctccaatcat cagcgtcttt tctttactaa atccagcaat ttgctggcca atcttttcat
      721 aaaagagagc atccggcttt tgagtttgca actgttctga gataaagact tgattgaaat
      781 aaggtgctag accagattga gccaaacgtt ctgtctgaat ggcagtaatg ccatttgtcg
      841 cagcatacaa gtcataatca cgctcaatga ggctgtccaa gagatcatga gcgcccgata
      901 gtgtttgtcc ctgctgggcg aggtaaaatt ggtaacgctg ggcaagaaaa ctaccgtctt
      961 tttcctgtcc aaaatgagca aataaacgag aaaagcgcgt gttaaccagt tcttgtttac
     1021 tgattttctt tagctccaag tctttccaga gagccttgtt cataggaacg taataatctt
     1081 tataagcctg aatatccgca actccttctt cttttagaag ttgggtcaaa gccacatcct
     1141 cagcagcatc aaaatcaaga agagtgtggt cgaggtcgaa gagtagaaat ttgtaggaca
     1201 atttgaggtt ttcctttcta gagggggtgc aatggttcaa atgggggtgt acaaataatg
     1261 attactcaat aatcgaatta agatattcct taaattccga ataaacttcg cctttaattc
     1321 tttctgcagt caaatctctt tcagtacgtc caaaatatat agattcattt gtaatatcta
     1381 atttatttaa gtcagttata attttggaaa tacaactata aggtatattt atttttataa
     1441 tttttgattg aacagctgct aaaaaatcta gaggatgcgt aagttttgtt cctgagtgcg
     1501 tgaagttacc tgattgtctg gtgatacgag gattaatttt agacccctca aaacaaaatg
     1561 tgccgcaatt caaagaaatt tctttgttaa ttttctcgat atcattagga ttgaaactct
     1621 gaaaaactcc ttctatacca ggttcgttta gtaagatttg gtttatttct aacggattaa
     1681 ttacccatac agaagcatga gcatgaatta tctcatcctc atcttcatca tcttctcgaa
     1741 caataacttg atcttcagtt aggtaagttt cattatcatt tttacaatca actgtagagg
     1801 cagcaaaaaa taatgcaacc aatgggtctg tagaccaatc taataaattt gttggtaagc
     1861 cataatgttg tgctaattct aaccattgta cttcgttttt cggccctaag atatcttcag
     1921 tcattgcctt actcataaat ttttcaagga gaacattttg agatggcata acaactactt
     1981 ctcctttagg gttgtaaaag tttgttcgat gaattgggat tctctctccc ctagaatcgg
     2041 aaacagaata agcctcacgc caaattccag gaatcaagcc atattcggaa ctcttttgcc
     2101 ctctatacca tagtctatga gatggattcg ctgaattaat ttctctaata gtttgaatgt
     2161 acgattcaat tgaatttaca aaa
//
LOCUS       DAVHSO010000117         2111 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.118, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000117 DAVHSO010000000
VERSION     DAVHSO010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2111)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.118"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            265..501
                     /locus_tag="VVR18_002200"
     CDS             265..501
                     /locus_tag="VVR18_002200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecX"
                     /protein_id="HEU6033644.1"
                     /translation="MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVR
                     YGIGCRRDFIVYHYRVAYRLYLEKLVMNRGFISC"
     gene            732..2018
                     /locus_tag="VVR18_002201"
     CDS             732..2018
                     /locus_tag="VVR18_002201"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HEU6033645.1"
                     /translation="MTSVVVVGTQWGDEGKGKITDFLSANAEVIARYQGGDNAGHTIV
                     IDGKKFKLHLIPSGIFFPEKISVIGNGMVVNPKSLVKELSYLHEEGVTTDNLRISDRA
                     HVILPYHIELDRLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFRERL
                     ERNLAEKNRLFEKLYDSKAIVFDDIFEEYYEYGQQIKKYVIDTSVILNDALDNGKRVL
                     FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKIDKVVGVCKAYTSRVGDGP
                     FPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVL
                     SGLDTVKICVAYDLDSQRIDYYPASLEQLKRCKPIYEELPGWSEDITGVRNLEDLPEN
                     ARNYVRRVSELVGVRISTFSVGPGREQTNILESVWS"
BASE COUNT          615 a          281 c          469 g          746 t
ORIGIN      
        1 tgaatttttt tatactagaa aatcagaacc ataataccta tataaaaata ttatagtttt
       61 aataggattt acccaaaagt tttaaggcgg tctttttaga actttaattg tttgaaattt
      121 aggtagcaaa tttgtttcta ttttgtcaac ttttcctatt tttatcttgt tgaggctggt
      181 attttaacaa ttcaggaatt gatagtgaat gtgtaaaatt ttttgttaga ataagtttat
      241 aaaaaagaaa aggagtattt gattatgtta caaaaaattt atgagcagat ggctaatttc
      301 tatgatagta ttgaagaaga gtatggtcct acatttggtg ataattttga ctgggaacat
      361 gttcatttta aatttttaat ttattattta gtgagatatg gcattggttg tcgtagggat
      421 tttatcgttt accattatcg tgttgcttat cgtttgtatc ttgaaaaatt ggtaatgaat
      481 cgggggttta tttcttgttg aggtaatttt agtaaatttc cgaactaatt tactctttta
      541 tggaaagata atagtaaata gctagtaatt tttctaaatc attttttaat agttggaaat
      601 agcaaatctt tctattgttt cttcttgata aaaaggcgat tttttattat aataaattgt
      661 aagatataat tgcaggtgag agtcctgcca tgtatgtgag aaaggaagag cctgagggct
      721 cagacaaaat tatgacttca gttgttgttg taggtaccca atggggtgat gaaggtaaag
      781 ggaagattac agacttcctt tcagcgaatg cagaagtgat tgcacgttac caaggtggtg
      841 ataatgctgg tcacacgatt gtgattgacg gtaagaaatt taagttgcac ttgattccat
      901 ctgggatttt cttccctgaa aaaatatctg tcattgggaa tggtatggtt gtaaatccta
      961 aatctcttgt aaaagagttg agctatcttc atgaggaagg tgtaacaact gataacttgc
     1021 gtatttctga tcgtgcgcat gttattttgc cttatcatat cgagttggat cgcttgcaag
     1081 aagaagctaa gggcgacaat aagattggta cgacaattaa gggaattggt ccagcttata
     1141 tggacaaggc tgctcgtgtt ggaattcgta ttgcagatct tttagataaa gatattttcc
     1201 gtgagcgttt agaacgtaac cttgctgaaa agaatcgtct ttttgaaaaa ttgtatgaca
     1261 gtaaagcgat tgttttcgat gatatttttg aagaatatta cgaatatggt caacaaatca
     1321 agaaatacgt gatagataca tctgttatct tgaatgatgc gcttgataat ggcaaacgtg
     1381 tgctttttga aggtgcacaa ggtgttatgc tagatatcga ccaaggtact tatccatttg
     1441 ttacgtcatc aaaccctgta gctggtggtg tgacaattgg ttctggtgtt ggtccaagca
     1501 agattgacaa ggttgtaggt gtatgtaaag cttatacgag tcgtgtagga gatggtcctt
     1561 tcccaactga gttgtttgat gaagtgggag aacgtatccg tgaagtgggt catgaatatg
     1621 gtacaacaac tggtcgtcca cgtcgtgtag gttggtttga ctcagttgtg atgcgtcata
     1681 gccgtcgtgt ttctggtatt actaaccttt ctttgaactc tattgatgtt ttgagcggtt
     1741 tggatactgt gaaaatctgt gtggcctatg atcttgacag tcaacgtatt gactactatc
     1801 cagctagtct tgagcaattg aaacgttgca agcctatcta tgaagagttg ccaggttggt
     1861 cagaagatat taccggagtt cgcaatttgg aagatcttcc tgagaatgcg cgtaactatg
     1921 ttcgtcgtgt gagtgaattg gttggcgttc gtatttctac tttctcagta ggtcctggtc
     1981 gtgaacaaac aaatatttta gaaagcgttt ggtcctaaga gatttttaag atttgtttaa
     2041 gataggtcgg gtatactata gacagttaca agaagacctc ctaacttgtt gtaacaaata
     2101 tcctaaactt t
//
LOCUS       DAVHSO010000118         2105 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.119, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000118 DAVHSO010000000
VERSION     DAVHSO010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2105)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.119"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            56..1546
                     /locus_tag="VVR18_002202"
     CDS             56..1546
                     /locus_tag="VVR18_002202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033646.1"
                     /translation="MNLERFLKLSIYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRN
                     RVATDISNSTYQEFHSKSSGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTL
                     NHYHWSLTVATLFSLMIMLLVPKIFASKMREVSLNLTNQNEAFLKSSETILNGFDVLA
                     SLNLLYVLPKKIKEAGILLKMVIQRKTTVETLAGAISFFLNIFFQISLVFLTGYLAIK
                     GIVKIGTIEAIGALTGVIFTALGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEP
                     NEVNRDFPLYEAKNICYKYGDKEILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGF
                     LRDYSGELRFCGDDIKKTSYLNMVSNVLYVDQKAYLFEGTIRDNILLEENYTDEEILQ
                     SLEQVGLSVKDFPNNILDYYVGDDGRLLSGGQKQKITLARGLIRNKKIVLIDEGTSAI
                     DRRTSLAIERKILDREDLTVIIVTHAPHPELKQYFTKIYQFPKDFI"
     gene            1805..>2105
                     /locus_tag="VVR18_002203"
     CDS             1805..>2105
                     /locus_tag="VVR18_002203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001290269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033647.1"
                     /translation="MSEIVEMSKKISDLNDKKEFHKKNCELRFQDSVLDNINSVPGTT
                     HLFSCLNIQTLVKIILYIFRYNSCMKIFNFRDKELIFFNKIVNGLIQNIEENLEDD"
BASE COUNT          743 a          249 c          384 g          729 t
ORIGIN      
        1 attgctaatt tatgcagcaa ctattaatgc tctggtgttg aatgaattaa ttgcgatgaa
       61 tttagagcgg tttttgaaat tgtcaatcta ccaaatgatt gtctggtgtg ggataatatt
      121 ccttgactgg gtagtgaaaa attatcaggt tgaagtgatc caagagttta atctagagat
      181 tcgaaataga gttgccacag acatctctaa ctctacctat caagaatttc atagtaaatc
      241 atcaggaaca tatctttcgt ggctaaataa tgatgttcag actttaaatg atcaggcttt
      301 taaacaactt tttttagtaa taaaaggaat ttctggtact atatttgcag ttgtgactct
      361 taatcactat cattggtcat tgactgtagc caccttgttt tcattaatga ttatgctact
      421 tgtaccaaaa atctttgcat cgaaaatgcg agaagttagt ctaaatttaa ctaaccaaaa
      481 tgaagctttt ttaaaatcta gtgagactat attgaatgga tttgatgtgt tagcgtcctt
      541 gaatctttta tatgtattgc ctaagaaaat taaagaagca ggaattttat taaagatggt
      601 tatacaaaga aagacaactg tagaaacgtt agcaggcgct attagcttct ttctcaatat
      661 tttttttcag atatctctcg tttttttaac aggctatctt gcaataaaag gaatagtgaa
      721 aattggtact attgaagcaa taggagcact aacaggtgtt atttttacag cgctaggtga
      781 attaggaggt caattatcct ctattattgg tacgaagcct atttttttaa aattgtattc
      841 aattaatcca attgagtcaa ataaaatgaa tgatatcgaa ccaaatgagg tgaatagaga
      901 ttttccgtta tatgaagcaa aaaatatttg ctataagtat ggagataaag aaatattaaa
      961 aaacttaaat ttttgttttc aacgtaatga aaagtattta attttaggtg aaagtggaag
     1021 cgggaaatct acattattaa aattattgaa tggctttttg agagattata gtggagaatt
     1081 gcgattctgc ggggatgata taaaaaaaac ctcctattta aatatggttt cgaatgttct
     1141 atatgtagat caaaaagctt atttgtttga aggtacgatt agagataata ttttattgga
     1201 agaaaattat actgatgaag aaatactaca gtctttagag caagttggtt tgagtgtaaa
     1261 agattttcct aataacattt tagattatta tgttggtgat gatgggagat tactgtcagg
     1321 agggcagaaa caaaaaatta ctttagctag agggctaatt agaaataaga aaatagtatt
     1381 aattgacgag ggaacttctg ctatcgatag gagaacttcg ttagcgattg aacgtaagat
     1441 attagataga gaggatttga ctgtcattat tgttacccat gctccgcatc cggaacttaa
     1501 acaatatttt actaagatat atcaatttcc aaaggatttt atttaagaat ataggggagg
     1561 gaaacatgag attctattgt gaagcttatg aggtaattac tgaagagaaa aaagtatcat
     1621 ttttttatgt agatgaaaaa cccttaaggt atctgttatt tgactatata tttctactag
     1681 ttctagctaa aaaaatatcc caatcttatg aactgcaccc caaaagttag atttattctg
     1741 tctaactttt ggggtgcagt tcattttgca tagttttggc attcatccta gatatccata
     1801 taaaatgtct gagattgttg aaatgtctaa aaaaatatca gatctaaacg ataaaaaaga
     1861 atttcacaaa aagaactgtg agttgaggtt tcaagatagt gttcttgata acataaatag
     1921 tgtcccgggt acaactcatt tatttagttg tttaaatatt caaacattag taaaaattat
     1981 tttatatatt tttcgataca acagttgtat gaaaatattt aattttagag ataaagagct
     2041 tatctttttt aataagattg taaatgggct gatacaaaat attgaggaga atttagagga
     2101 tgata
//
LOCUS       DAVHSO010000119         2100 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.120, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000119 DAVHSO010000000
VERSION     DAVHSO010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2100)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.120"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..177
                     /locus_tag="VVR18_002204"
     CDS             <1..177
                     /locus_tag="VVR18_002204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease"
                     /protein_id="HEU6033648.1"
                     /translation="IIRQALKNTEYKDQISSTVLPDIKIKLPIDSRGTPDWNYMERYI
                     EDLKLKCNIANYNI"
     gene            233..550
                     /locus_tag="VVR18_002205"
     CDS             233..550
                     /locus_tag="VVR18_002205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000968321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3847 domain-containing protein"
                     /protein_id="HEU6033649.1"
                     /translation="MMASKRLSIEEQIEKKEESIKQLQNQKRQLKKKLNEQERKARNK
                     RLIEKGAVFESIFEESIDLTKDEFYKLIKTLNDEEIRLNIMEILEERIDDNVEKSSKD
                     EIT"
     gene            864..>2100
                     /locus_tag="VVR18_002206"
     CDS             864..>2100
                     /locus_tag="VVR18_002206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019213953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="HEU6033650.1"
                     /translation="MADSFHFSVNIISRGKGKSAVASAAYISGEKIKNEWDGVTHDYT
                     RKEKILVKNIILPDHIPKEFNDRSTLWNKVEMAEKNSNAQLARQFIIGLPKELSLSEN
                     KNLVERYIKENLTSQGMIVDYAIHDESQDKNGNIHCHIMTIMRPINEKGEKVLNKNGK
                     PKTRKVELTTWNDTGNVEKWRENFSDLCNKYLERAGAEKRVDHRSFKRQNSDYLPTIH
                     LGSAASAMERKGIETDKGNYNREIRKYNQLVKTIKEEIKTLKGWIGNLLDNLSTAYEK
                     FKDIERDKVIDNPKLFNLTNYLLTYSEIQKEKSKYLKGYAKTNKEKYDFKKLTSAYSY
                     LRKNNIETIGQLQTKIETLKSNSYRLNRKAKTIHKEMEDVEKKILYYEIYKAKKEVYE
                     EYQKKNIFTKEAFYNKHKKD"
BASE COUNT         1014 a          247 c          342 g          497 t
ORIGIN      
        1 attattaggc aagctttaaa aaatactgaa tataaagatc aaatatctag cacagtattg
       61 ccagatatca aaattaaatt accgatagac agtagaggta ctccagattg gaattacatg
      121 gaaagatata tagaagactt aaaattaaaa tgcaatatag caaattataa tatttaaaac
      181 aagaacgatt agaaataaaa atctagtcgt tttttatttt aagaaaggat acatgatggc
      241 aagtaaaaga ttaagtattg aagaacagat tgaaaagaaa gaagaaagca ttaagcaatt
      301 acaaaatcaa aaaagacagt tgaagaaaaa acttaatgaa caagaaagaa aagcaagaaa
      361 caaaagactt atagaaaaag gtgcagtgtt tgaaagtatt tttgaagaaa gtattgattt
      421 aacaaaagat gaattttata agttaataaa aacgttaaat gatgaagaaa taagattaaa
      481 cataatggaa attttagaag aaagaataga tgataatgta gaaaaatcat ctaaagatga
      541 aataacataa ttgtcccttg gttacaaggg cgcaattata caccctaaag ggtgcttgcg
      601 tcctgcggag tcaaaccctt gcagggagca acaaccattc gctttttaaa agtcaagggt
      661 aaataaactc gctaaggctc gcccttgact tttaaaattt gaaatgaaag taacaattaa
      721 gccgacatac tgaaacaaca aaaattaatt cagtagtcgg cttttttaat tctatcattt
      781 caaaacgctc attcacaaag aggatataaa aaaactatta agtctccacc taaaacaaca
      841 aagaaagaaa ggaagtgata aaaatggcag acagttttca tttttcagta aacataatat
      901 caagaggaaa aggcaaaagt gcagtagcaa gtgcagcata tataagtgga gaaaaaataa
      961 aaaatgaatg ggacggagta acccatgact acacaagaaa agaaaaaata ttagtaaaaa
     1021 atataatatt gcctgatcat ataccaaaag aatttaatga taggtctacc ttatggaata
     1081 aagtagaaat ggcagaaaaa aattctaatg cacaactagc aagacaattc ataataggac
     1141 taccaaaaga gttatcttta agtgaaaata aaaacctggt tgaaagatat ataaaagaaa
     1201 atttaacatc acaaggaatg atagtagatt atgcaattca tgatgagagt caagataaaa
     1261 atggaaatat ccattgtcat ataatgacca taatgcgacc aataaacgaa aaaggagaaa
     1321 aagtattaaa caaaaatgga aaaccaaaga caagaaaagt agaactaaca acctggaacg
     1381 atacaggcaa tgtagaaaaa tggagagaaa atttttcaga tctttgtaac aaatatttag
     1441 aaagagcagg agcagaaaaa agagtagacc ataggagttt taaaagacaa aattcagatt
     1501 atctaccgac aatccattta ggatcagcag caagtgcaat ggaaagaaag ggaatagaaa
     1561 ctgacaaggg aaactataat agagaaataa gaaaatataa tcaacttgta aaaacaataa
     1621 aagaagagat aaaaacatta aagggttgga taggaaattt attagataac ttatctactg
     1681 cttatgaaaa atttaaagat atagaaagag ataaggtaat agacaaccct aaacttttta
     1741 atctaacaaa ttatctatta acttattcag aaattcaaaa agaaaaaagt aaatatctaa
     1801 aaggatatgc aaaaactaat aaagaaaaat atgacttcaa aaagctaaca agtgcatata
     1861 gttatttaag aaaaaacaac atagaaacca taggtcagtt acaaacaaaa atagaaactt
     1921 taaagtctaa tagttatagg ctaaatagaa aagcaaagac aatccataaa gaaatggaag
     1981 atgtagaaaa gaaaattcta tactatgaaa tctacaaagc caaaaaagaa gtttatgaag
     2041 aatatcaaaa gaaaaatata ttcacaaaag aagcatttta taacaaacat aagaaagata
//
LOCUS       DAVHSO010000120         2093 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.121, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000120 DAVHSO010000000
VERSION     DAVHSO010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2093)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.121"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(140..298)
                     /locus_tag="VVR18_002207"
     CDS             complement(140..298)
                     /locus_tag="VVR18_002207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase domain-containing protein"
                     /protein_id="HEU6033651.1"
                     /translation="MSLLETAKRHQLNSEKYLSYLLECLPNEETLVNKEVLEAYLPWT
                     KVVQEKCK"
     gene            complement(370..819)
                     /locus_tag="VVR18_002208"
     CDS             complement(370..819)
                     /locus_tag="VVR18_002208"
                     /inference="COORDINATES: protein motif:HMM:NF015038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033652.1"
                     /translation="MVNCEQLEAYRQLEEAALVGCWAHVRRKFFEVPPKQADKSSLGA
                     KGLAYCDQLFSLERDWEALPADERLQKRQEHLQPLLEDFFAWCRRQSVLSGSKLGRAI
                     EYSLKYEETFKTILKDGHLVLSNNLAERAIKSLVMGRSKRVQWTLLA"
     gene            complement(892..1482)
                     /locus_tag="VVR18_002209"
                     /pseudo
     CDS             complement(892..1482)
                     /locus_tag="VVR18_002209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000457791.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(1406..1600)
                     /locus_tag="VVR18_002210"
     CDS             complement(1406..1600)
                     /locus_tag="VVR18_002210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033653.1"
                     /translation="MKIIQQQSATIDSLTNELALLREQVAYLTQKLYGKSSEKSVCPS
                     GQLNLFEEESPSEEDGDVPS"
     gene            complement(1665..2015)
                     /gene="tnpB"
                     /locus_tag="VVR18_002211"
     CDS             complement(1665..2015)
                     /gene="tnpB"
                     /locus_tag="VVR18_002211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HEU6033654.1"
                     /translation="MTIHLSSLGQVYLVCGKTDMRQGIDSLAYLVKTHFELDPFSGQV
                     FLFCGGRKDRFKALYWDGQGFWLLYKRFENGRLTWPSTEKDVKALTPEQVDWLMKSFS
                     ITPKINSSESRDFY"
BASE COUNT          591 a          451 c          403 g          648 t
ORIGIN      
        1 gtcaggggtt ttgtaagtta catctagttg agaggggtat gaatgatttg ggttgaatat
       61 cgtaaccgcc caataacgaa gtatattgaa aaatctccag actagagaac tcacggatag
      121 ttcctaatct ggagatttct tatttgcact tttcttgtac aactttagtc cacggtaaat
      181 aggcctctaa aacctctttg tttacgagag tttcctcgtt tggaagacat tctagaagat
      241 aggatagata tttctcacta tttaattgat gacgtttagc tgtttccaat aagctcataa
      301 taatagctct tgctttagct ccttcaaaaa ctttgagaaa acaaccaccc tcgctttttt
      361 aaactgagct taggctaaaa gagtccactg gactctttta ctccgtccca taaccaatga
      421 tttaatggcg cgttcagcta gattattgga aaggaccaga tgtccgtctt ttaaaatggt
      481 cttaaaggtt tcttcatact tgaggctgta ttcaattgcc cttcctagtt ttgaacccga
      541 taaaactgac tgacgacggc accaagcaaa gaagtcttcc agtaggggtt ggagatgttc
      601 ttgacgtttc tgtagtcgtt catcagctgg caaagcctcc cagtctcttt ccaaggaaaa
      661 taactgatca caataagcta aacctttagc tcctaaggat gatttatctg cttgcttggg
      721 gggcacttca aaaaacttcc ttctcacatg cgcccaacat ccaacaagtg cagcttcttc
      781 cagttgacga taagcttcta gctgttcgca gtttaccaag cttagcgtcg ccttactcct
      841 aaactttgga ctgctatcgc ataggcagaa ctagaggact aaagtcctaa gttactgccg
      901 caacatgtca caatgaacat agccagaata atctcctagg aattcttgta ctactaaacc
      961 actccgacgc tgatcatggt ggtacagcgt gattgcttga ttctcagctt tcccagacaa
     1021 aaaagtccaa tagtaagtca actgactatc actctctaga acccgataag aggtttcatc
     1081 cgcatgaagt aagggcttga gtcaatagtc tcgttataaa ggggctttag gaataggagc
     1141 tttcacgatt ttatcactcg gatttttatc actgcatgct tggcatttgt aagcgtgttg
     1201 gatatgatct atgcgtttta attgcgcagg aataaagacc aattcttgtc cttgaagact
     1261 ccctccaatc tcttttagat ctccctgaca atcagggcaa atcctctctt ctacttgatg
     1321 atgaacttct tctgaatcaa attgggcaag aagagcttgg cgtttccctt tagatttctt
     1381 acgtttgtag gtaatttcct ctgtttcaac tgggaacatc tccatcttcc tcagatggag
     1441 actcttcctc aaaaaggttg agttgtccag aggggcaaac acttttctca gaggattttc
     1501 catagagctt ttgagtcaga taagccactt gttcacgaag aagggcaagt tcattggtga
     1561 gactatcaat tgtagcactc tgttgttgaa tgattttcaa tcttcttcca tgagcttccc
     1621 tctctgtttt ctaactttat tatactaaaa agaaagtcct catttcaata gaaatcacga
     1681 ctttctgatg agtttatttt gggagtgata gaaaagctct tcataagcca gtctacttgt
     1741 tcaggtgtga gagctttgac atccttttct gtactgggcc aagtcagtct gccgttctca
     1801 aagcgtttat atagtagcca aaatccttga ccatcccagt aaagggcttt aaagcggtct
     1861 ttacgtccac cacaaaagag aaaaacttga cctgagaaag gatctaattc aaagtgggtt
     1921 ttaaccagat aagccagtga atcaatgcct tgcctcatat ccgttttccc acatacgaga
     1981 tagacctgcc ctaggctaga tagatgaatt gtcatagagc aacaccttat ccaaaagctg
     2041 ttctatcatt tcgagattga gagattgaaa aaaacttact tcaagcttgc caa
//
LOCUS       DAVHSO010000121         2062 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.122, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000121 DAVHSO010000000
VERSION     DAVHSO010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2062)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2062)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.122"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(87..548)
                     /locus_tag="VVR18_002212"
     CDS             complement(87..548)
                     /locus_tag="VVR18_002212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000514209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033655.1"
                     /translation="MRKERREQGNLERKKRVVKKRKILLEELKAFVEAHPDAFLREIA
                     ARFDCALPSVWAVLKQIKVILKKTTSFREQKPEKVSEFLDILDNLKDLPVLYIDETGI
                     NRYLYRPYAGAPRGEKVYDKISGRRFERTNEVEQKLNGSFLIRYIDSQIRE"
     gene            complement(545..655)
                     /locus_tag="VVR18_002213"
                     /pseudo
     CDS             complement(545..655)
                     /locus_tag="VVR18_002213"
                     /inference="COORDINATES: protein motif:HMM:NF013842.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            925..1305
                     /locus_tag="VVR18_002214"
     CDS             925..1305
                     /locus_tag="VVR18_002214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEU6033656.1"
                     /translation="MTYLEKWFDFNRRQKEIESLLEETIAQQSEQSLTLKEFYLLYYL
                     DLAEEKSLRQIDLPDKLHLSPSAVSRMVARLEAKNCGLLSRMCCHQDRRSSFICLTND
                     GQKTLASLQKTVEESLEASLDFLI"
     gene            1404..1625
                     /locus_tag="VVR18_002215"
     CDS             1404..1625
                     /locus_tag="VVR18_002215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HEU6033657.1"
                     /translation="MIEITYIDASKNERTVTFESYEDFERSQQACLIGVADYYPVQKL
                     TYKGHNLDYHGTYGDIFFYLMKQDLSQYN"
     gene            1642..1956
                     /gene="trxA"
                     /locus_tag="VVR18_002216"
     CDS             1642..1956
                     /gene="trxA"
                     /locus_tag="VVR18_002216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003004519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEU6033658.1"
                     /translation="MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEE
                     LSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAE
                     LS"
BASE COUNT          659 a          412 c          380 g          611 t
ORIGIN      
        1 agataagttt tttataaaga cacgtaactg agtataaatc agctaatttt tggtttacat
       61 ccctattttt atgcataatt attctgtcat tctctaattt gtgaatcaat atatctgatt
      121 agaaaactac cattgagttt ttgctccacc tcattagtcc gctcaaaacg ccgtccgcta
      181 atcttgtcat agactttctc ccctctagga gcccctgcat aaggacgata gaggtagcgg
      241 ttgattcccg tttcgtcaat atataggact ggtaaatctt ttaggttatc caaaatatca
      301 agaaactcag aaactttctc aggcttttgt tccctaaaac tggtcgtctt ttttaaaatg
      361 accttaatct gctttaaaac tgcccatacg gagggcaaag cacaatcaaa acgggccgca
      421 atttcccgta aaaaagcgtc tggatgagcc tctacaaagg ctttcaattc ttctaaaagg
      481 atcttacgct ttttgacgac tcgctttttc cgctctaagt tcccttgttc acgtctttct
      541 tttctcacgt gaagagagtt ctgacgccaa caccaaaaac cttggccgcc tcgacatgtc
      601 tgtgccctcc tttgatggaa tctaatgatc cttgtttaaa atcagtacta tatgcatagc
      661 tttattagac catgcttatt ttaaactaag caactataga tagagaaatg aaataaaatc
      721 tgaattcgaa tgcgataagg agttagaaat tgaaacaata ggatttcccc attattcaca
      781 caaaaataaa accactaaaa aacagagctt gccagtattc ttgaaaagta gtataattat
      841 tgcatgcgca atcatcttgt gacgcagaga ctgcccgtta atggactttc ttctatttat
      901 gactctaaaa agaaaggaga cactatgacc tatttggaaa aatggtttga cttcaatcgg
      961 cgtcagaaag aaattgaaag tctcttggaa gagaccattg cccaacagag cgagcaaagt
     1021 ctgaccttga aagagttcta cctgctctac tatctggact tggctgaaga aaaatctcta
     1081 cgccagattg acctgccaga taagcttcat ctgagcccga gcgcagtttc taggatggtg
     1141 gctcgcttgg aagctaaaaa ttgcggtcta ctcagtcgca tgtgttgcca tcaagataga
     1201 cgctctagtt ttatctgcct gacaaatgat gggcaaaaga cactggcctc gctacaaaag
     1261 actgtcgaag aaagcttgga agcaagtttg gatttcttga tttaagatga ttttaaaaaa
     1321 agttgcgtgc gcaatcattt ttcttgacat tctcttttat aaggagtaaa ataaagttag
     1381 cattaaacaa aggagtttta aatatgattg aaattaccta tatagatgcc agcaagaacg
     1441 aaagaactgt gactttcgag tcttatgaag actttgaacg ttcgcaacaa gcttgcctta
     1501 tcggcgtcgc agactactac cctgtccaaa aattaactta caagggtcat aatttggact
     1561 accatgggac ttatggagat atcttcttct atctcatgaa acaagattta agccaatata
     1621 actaaaaaaa ggagaaatac aatggcaaaa gcaattacag atgcaacatt cgaacaagaa
     1681 acaaaagacg gtttggtctt agtagacttc tgggcaactt ggtgtggtcc atgtcgtatg
     1741 caaggtccaa tcttggacaa attgtctgaa gaactttcag aagatgtctt gaaaatcgtt
     1801 aaaatggacg ttgatgaaaa tccaaacaca gctcgtgctt ttggaatcat gtctattcca
     1861 actcttctct tcaaaaaaga cggccaagtt gtcaaacaag ttgcaggtgt tcacacagca
     1921 gaacaaatca aggccatcat tgctgaattg agctaatcaa acgagagacc aagtactttc
     1981 tttggtctct tttttcttgc tctttgccat ttttcaaaaa atatgctaga ctatagtaga
     2041 ttgaaactag aatagtacac ct
//
LOCUS       DAVHSO010000122         2048 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.123, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000122 DAVHSO010000000
VERSION     DAVHSO010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2048)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.123"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            41..841
                     /locus_tag="VVR18_002217"
     CDS             41..841
                     /locus_tag="VVR18_002217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1189 domain-containing protein"
                     /protein_id="HEU6033659.1"
                     /translation="MLPYPFSYFSSIWGFRKPLSKRFELNWFQLLFTSIFLISLSMVP
                     IAIQNSSQETYPLETFIDNVYEPLTNEVVQDLSEHATIVDGTLTYTGTASQTPSVVIG
                     PSQIKELPKDLQLHFDTNELVISKESKELTRISYRAIQTENFKSKDSLTQAISKDWYQ
                     QNRVYISLFLVLGASFLFGLNFFIVSLGASLLLYITKKSRLFSFRTFKECYHFILNCL
                     GLPTLITLILGLFGQNMTTLITVQNILFVLYLVTIFYKTHFRDPNYHK"
     gene            851..1837
                     /locus_tag="VVR18_002218"
     CDS             851..1837
                     /locus_tag="VVR18_002218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU6033660.1"
                     /translation="MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKEL
                     NYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIAT
                     GKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
                     VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNR
                     IYFADEFLEEKGYKFSKRLFKHDPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDS
                     VNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQLIAHKIIEK"
BASE COUNT          619 a          469 c          354 g          606 t
ORIGIN      
        1 aataatactc atatagaaaa caccttttag aaagatacct atgcttccat atccattttc
       61 ctatttttca agtatttggg ggtttcgtaa gcccctgtcc aaacgtttcg agctcaactg
      121 gtttcaactt ctctttacca gtatcttcct tatcagcttg tctatggtac ccattgctat
      181 ccaaaacagc tcccaggaga cctatccgct agaaactttt atcgataatg tctatgaacc
      241 tctgacaaat gaggttgtcc aggatctctc tgaacatgct acaattgtcg atggcacatt
      301 aacttatact ggaacagcta gtcaaacccc ttctgttgtg attggtccaa gtcaaatcaa
      361 ggaattacct aaggacttgc aactgcattt cgatacaaat gagctagtca tcagcaagga
      421 aagcaaggaa ctgacccgca tctcttaccg agccattcag actgagaatt tcaaaagcaa
      481 agacagcttg acccaagcaa tttctaaaga ctggtaccaa caaaatcgtg tctatatcag
      541 cctcttccta gttctcggtg cgagcttcct ctttggtttg aatttcttta tcgtctctct
      601 aggagctagt cttctccttt atatcactaa gaaatcacgc ctcttttcat ttagaacctt
      661 taaagagtgc tatcacttta tcttgaactg tttaggattg ccgactctga ttacacttat
      721 tttgggatta tttggccaaa atatgacaac cctgattact gtacaaaata ttctttttgt
      781 tctgtatctg gtcactatct tttataaaac acatttccgt gatccaaatt accataaata
      841 ggagattttt atgcccgtta cgattaaaga cgtggccaag gctgctggtg tttcgccttc
      901 aaccgtaacc cgtgttattc aaaataaatc aaccattagc gacgaaacaa aaaaacgcgt
      961 tcgcaaagct atgaaggaac tcaactacca cccaaacctc aacgctcgta gcttggtaag
     1021 cagctatact caggttatcg gattagttct tcctgatgac tcagacgcct tctaccagaa
     1081 tcctttcttt ccatcggttc tacgtggcat ctctcaagtc gcatctgaaa accactatgc
     1141 cattcagata gcaacaggga aagatgagaa ggagcgtctc aacgctattt cacaaatggt
     1201 ctacggcaag cgtgtagatg ggctaatctt tctctatgcc caagaagaag accctctcgt
     1261 aaaactcgtc gcagaagaac agttcccctt ccttatccta ggtaaatctc tatctccttt
     1321 catcccactt gtcgacaacg acaatgttca agctggtttt gatgcgactg aatatttcat
     1381 caaaaaaggc tgcaaacgca ttgcctttat cggaggaagt aaaaagctct tcgtgaccaa
     1441 agaccgttta acaggctatg aacaggcgct taaacattac aaacttacca ctgacaacaa
     1501 tcgcatctac tttgccgacg agtttctgga agaaaagggc tataaattta gcaagcgatt
     1561 attcaagcac gatccacaaa ttgatgctat catcacaacc gatagcctcc tagctgaagg
     1621 tgtttgtaac tatattgcca aacaccagct ggatgtccct gttctcagct ttgactcggt
     1681 taatcccaag ctcaacttgg cagcctatgt cgatatcaat agtttagagc ttggtcgtgt
     1741 ttcccttgaa actattctcc agattattaa tgataataaa aacaataaac aaatttgtta
     1801 ccgtcaattg atcgcccaca aaattatcga aaaataagag actgggcaaa aagtcgttaa
     1861 aagcaaaaac gcatactatc aggtattgaa aaaacttgat actatgcgtt ttattgtggg
     1921 aagatttact tccttttcta ctgaaattga gtcttttccc aagatctttt tatactcaat
     1981 gaaaatcaaa gtgcaaacta ggaagctagc cacaggttgc tcaaaacact gttttgaggt
     2041 tgtggata
//
LOCUS       DAVHSO010000123         2045 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.124, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000123 DAVHSO010000000
VERSION     DAVHSO010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2045)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.124"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            82..519
                     /locus_tag="VVR18_002219"
     CDS             82..519
                     /locus_tag="VVR18_002219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HEU6033661.1"
                     /translation="MEQLHFITKLLDIKDPNIKILDIINMDTHKEIIAKLDYEAPSCP
                     DCGSLMKKKEPEKFFGLIEDNLKQVHPIFQTVFKTFLKDKEKIVNALQLHYSNAKLEA
                     TNNLIKLIKCNAFGFRNFENFKKRIFIALNIKKERTKFVLSRA"
     gene            complement(653..740)
                     /locus_tag="VVR18_002220"
     tRNA            complement(653..740)
                     /locus_tag="VVR18_002220"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(704..706),aa:Ser,seq:gct)
     gene            complement(747..820)
                     /locus_tag="VVR18_002221"
     tRNA            complement(747..820)
                     /locus_tag="VVR18_002221"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(784..786),aa:Ile,seq:gat)
     gene            complement(856..926)
                     /locus_tag="VVR18_002222"
     tRNA            complement(856..926)
                     /locus_tag="VVR18_002222"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(892..894),aa:Gly,seq:tcc)
     gene            complement(946..1018)
                     /locus_tag="VVR18_002223"
     tRNA            complement(946..1018)
                     /locus_tag="VVR18_002223"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(983..985),aa:Phe,seq:gaa)
     gene            complement(1022..1095)
                     /locus_tag="VVR18_002224"
     tRNA            complement(1022..1095)
                     /locus_tag="VVR18_002224"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1059..1061),aa:Met,seq:cat)
     gene            complement(1109..1198)
                     /locus_tag="VVR18_002225"
     tRNA            complement(1109..1198)
                     /locus_tag="VVR18_002225"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1160..1162),aa:Ser,seq:tga)
     gene            complement(1209..1282)
                     /locus_tag="VVR18_002226"
     tRNA            complement(1209..1282)
                     /locus_tag="VVR18_002226"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1246..1248),aa:Ile,seq:cat)
     gene            complement(1296..1369)
                     /locus_tag="VVR18_002227"
     tRNA            complement(1296..1369)
                     /locus_tag="VVR18_002227"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1333..1335),aa:Met,seq:cat)
     gene            complement(1375..1448)
                     /locus_tag="VVR18_002228"
     tRNA            complement(1375..1448)
                     /locus_tag="VVR18_002228"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1412..1414),aa:Pro,seq:tgg)
     gene            complement(1464..1537)
                     /locus_tag="VVR18_002229"
     tRNA            complement(1464..1537)
                     /locus_tag="VVR18_002229"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1501..1503),aa:Arg,seq:acg)
     gene            complement(1547..1632)
                     /locus_tag="VVR18_002230"
     tRNA            complement(1547..1632)
                     /locus_tag="VVR18_002230"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1596..1598),aa:Leu,seq:taa)
     gene            complement(1640..1711)
                     /locus_tag="VVR18_002231"
     tRNA            complement(1640..1711)
                     /locus_tag="VVR18_002231"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1677..1679),aa:Gly,seq:gcc)
     gene            complement(1734..1806)
                     /locus_tag="VVR18_002232"
     tRNA            complement(1734..1806)
                     /locus_tag="VVR18_002232"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1771..1773),aa:Thr,seq:tgt)
     gene            complement(1825..1906)
                     /locus_tag="VVR18_002233"
     tRNA            complement(1825..1906)
                     /locus_tag="VVR18_002233"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1870..1872),aa:Leu,seq:tag)
     gene            complement(1912..1984)
                     /locus_tag="VVR18_002234"
     tRNA            complement(1912..1984)
                     /locus_tag="VVR18_002234"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1949..1951),aa:Lys,seq:ttt)
BASE COUNT          625 a          521 c          405 g          494 t
ORIGIN      
        1 atggagccta ttttgtgtag aaaaaaagtc ccatatgacc tataatgaaa agcgacaaaa
       61 caactcatta gaaagaatca tatggaacaa ttacatttta tcacaaaatt actagacatt
      121 aaagacccaa acatcaagat tctagatatc atcaatatgg atacccacaa agaaattatc
      181 gctaagctgg attatgaggc tccatcttgc cctgattgtg gaagtctaat gaagaaaaag
      241 gaaccagaga aatttttcgg acttattgag gacaatctta agcaggttca tcctattttt
      301 cagactgtct ttaaaacctt cctcaaagat aaagaaaaga ttgtcaacgc ccttcaacta
      361 cactattcta acgccaaact ggaagcgacc aataatctca tcaaacttat caagtgcaat
      421 gcctttggtt ttcgaaactt tgaaaacttt aaaaaacgga tttttatcgc tttgaacatc
      481 aaaaaagaaa ggacgaaatt tgtcctttct cgagcttagc ttttcttcaa cccactacag
      541 ttgacaaaga gccataaaaa taacttcaga ttagtaattc aattaagttt tacggatctg
      601 aagctttatt gtctctaaaa ataaaaaaga gagttacaaa ctctcattaa aacggagaat
      661 aagggattcg aacccttgcg ccagttaccc gacctaacga tttagcaaac cgtcctcttc
      721 agcctcttga gtaattctcc aattaatggg cacgagtgga ctcgaaccac cgacctcacg
      781 cttatcaggc gtgcgctcta accacctgag ctacgcgccc aagttaaaaa acttggtaat
      841 ttgaacaaag ttcaaagcgg gtgacgagaa tcgaactcgc gacaacagct tggaaggctg
      901 tagttttacc actaaactac acccgcataa atactatcaa taaaatggcg cgagacggaa
      961 tcgaaccgcc gacacatgga gcttcaatcc attgctctac caactgagct accgagcctt
     1021 attgcgggag caggatttga acctacgacc ttcgggttat gagcccgacg agctaccgag
     1081 ctgctccatc ccgcgttaat aatataaaag gaggatgtgg gattcgaacc cacgcacgct
     1141 tttacacgcc tgacggtttt caagaccgtt cccttcagcc ggacttgggt aatcctccaa
     1201 tattcaaatg gaccttgtag gacttgaacc tacgaccact cggttatgag ccgagagctc
     1261 taaccagctg agctaaaggt ccgacaagat cattatagcg gcgaagggga tcgaaccccc
     1321 gacctcccgg gtatgaaccg gacgctctag ccagctgagc tacaccgcca tgaatcggga
     1381 agacaggatt cgaacctgcg acaccttggt cccaaaccaa gtactctacc aagctgagct
     1441 acttcccgag ttaaatagaa aaatgcaccc tagaggagtc gaacctctaa ccgcctgatt
     1501 cgtagtcagg tactctatcc agttgagcta agggtgctcc atattatgcc gaggaccgga
     1561 atcgaaccgg tacgatcgtt accaatcgca ggattttaag tcctgtgcgt ctgccagttc
     1621 cgccaccccg gcctctctaa gcgaacgacg ggattcgaac ccgcgacccc caccttggca
     1681 aggtggtgtt ctaccactga actacgttcg cactgttttc ttctatctaa aaatgccggc
     1741 tacatgactt gaacacgcga ccctctgatt acaaatcaga tgctctacca actgagctaa
     1801 gccggctcat ttgttatatc ttaatgcggg ttaagggact tgaaccccca cgccgttaag
     1861 cgccagatcc taaatctggt gcgtctgcca attccgccaa acccgcatat atgacccgta
     1921 ctgggctcga accagtgacc cattgattaa aagtcaattg ctctaccaac tgagctaacg
     1981 agtctaaaat aacttgcgtt accttaaacg gtcccgacgg gaatcgaacc cgcgatcttc
     2041 gccgt
//
LOCUS       DAVHSO010000124         1873 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.125, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000124 DAVHSO010000000
VERSION     DAVHSO010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1873)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.125"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            368..1714
                     /gene="gdhA"
                     /locus_tag="VVR18_002235"
     CDS             368..1714
                     /gene="gdhA"
                     /locus_tag="VVR18_002235"
                     /EC_number="1.4.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="HEU6033662.1"
                     /translation="MTSAKEYIQSVFETVKARNGHEAEFLQAVEEFFNTLEPVFEKHP
                     EYIEENILARITEPERVVSFRVPWVDRDGKIQVNRGYRVQFNSAVGPYKGGLRFHPTV
                     NQGILKFLGFEQIFKNVLTGLPIGGGKGGSDFDPKGKTDAEVMRFCQSFMTELQKHIG
                     PSLDVPAGDIGVGGREIGYLYGQYKRLNQFDAGVLTGKPLGFGGSLIRPEATGYGLVY
                     YTEEMLKANGNSFAGKKVVISGSGNVAQYALQKATELGATVISVSDSNGYVIDENGID
                     FDLLVDVKEKRRARLTEYAAEKATATYHEGTVWTYAGNYDIALPCATQNEINGEAAKR
                     LVAQGVICVSEGANMPSDLDAIKVYKENGIFYGPAKAANAGGVAVSALEMSQNSLRLS
                     WTREEVDGRLKDIMTNIFNTAKTTSETYGLDKDYLAGANIAAFENVANAMIAQGIV"
BASE COUNT          592 a          340 c          360 g          581 t
ORIGIN      
        1 ttggatttct tctttagtta atttcatatc actattatat aatgattttt gattttagtc
       61 tggtataaat attgctttcc tccaaaatgg tcataatttt actagcaaat ctaacatatc
      121 acggataaat taacaagtga tttctgaatt gctaaacatt ttcttttctt atagcatacc
      181 atactttaag attttgtctt tgagaaagat atttccaaga aaaacgttcg tttttttatc
      241 tattttcaaa aaaaccaaaa actgaattga aagaattttt agaaaatttc tgttttttct
      301 ttacagtgaa aaaaaattct gctataatgt cttatgtaat aaaatatgac aataaaagga
      361 gaacgatatg acatctgcta aagaatatat ccaaagcgtg tttgaaactg tgaaagctcg
      421 taacgggcac gaggctgaat tcctccaagc tgttgaagaa tttttcaaca ctttggaacc
      481 tgtatttgaa aaacaccctg agtatatcga agaaaatatc ttggcacgta ttactgagcc
      541 tgagcgcgtg gtttctttcc gtgttccttg ggttgaccgt gatggaaaaa ttcaagtaaa
      601 ccgtggttac cgtgttcaat tcaactcagc tgttggacca tacaaaggtg gacttcgttt
      661 ccacccaact gtaaaccaag ggatcttgaa attcctcgga tttgaacaaa tctttaaaaa
      721 tgtcttgact ggacttccta tcggtggagg taaaggtgga tcagacttcg atcctaaagg
      781 taaaacagat gctgaagtga tgcgcttctg ccaaagcttc atgactgaat tgcaaaaaca
      841 catcggacca tcacttgacg tacctgctgg tgatatcggt gttggtggac gtgaaattgg
      901 ttacctttac ggtcaataca aacgtcttaa ccaatttgat gctggtgtct tgactggtaa
      961 acctcttgga tttggtggta gcttgattcg tccagaagca actggttacg gtttggttta
     1021 ctatactgaa gaaatgctca aagctaacgg taacagcttt gctggtaaga aagtcgttat
     1081 ttcaggttct ggtaacgttg ctcaatatgc tcttcaaaaa gcaactgaac tcggtgcaac
     1141 tgttatttct gtttctgact caaatggtta tgtcatcgat gaaaatggta tcgacttcga
     1201 tcttttggtt gatgttaaag aaaaacgtcg tgctcgtttg actgagtatg cagctgaaaa
     1261 agcaactgca acctaccacg aaggtactgt atggacttac gctggaaact atgacattgc
     1321 tcttccatgt gccactcaaa acgaaatcaa cggtgaagca gctaaacgtt tggttgctca
     1381 aggcgttatc tgtgtatctg aaggtgccaa catgccgagc gaccttgatg ccatcaaagt
     1441 ttacaaagaa aatggtatct tctacggacc tgcaaaagct gccaacgctg gtggtgtagc
     1501 cgtttcagcc cttgaaatga gccaaaacag ccttcgcctc tcatggactc gtgaagaagt
     1561 tgatggacgt ctcaaagaca tcatgaccaa catctttaac acagctaaaa caacttcaga
     1621 aacatatggt cttgataaag actaccttgc aggagctaac attgctgcct ttgaaaatgt
     1681 agcaaacgct atgattgcac aaggtattgt ttaagattta tttactcaat cctcaatcac
     1741 tacgattggg gatttttagc ttgaattaaa aaattggaaa atctaattaa ataaaatgaa
     1801 atgaaataaa aactgaacaa attgattgcg gaattcaaac caatttctaa catatttcta
     1861 gaaattaatt tga
//
LOCUS       DAVHSO010000125         1836 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.126, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000125 DAVHSO010000000
VERSION     DAVHSO010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1836)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.126"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            228..497
                     /gene="blpJ"
                     /locus_tag="VVR18_002236"
     CDS             228..497
                     /gene="blpJ"
                     /locus_tag="VVR18_002236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpJ"
                     /protein_id="HEU6033663.1"
                     /translation="MNTKMLSQLEVMDTEMLAKVEGGYSSTDCQNALITGVTTGIITG
                     GTGAGLATLGVAGLAGAFVGAHIGAIGGGLTCLGGMVGDKLGLSW"
     gene            566..796
                     /gene="blpU"
                     /locus_tag="VVR18_002237"
     CDS             566..796
                     /gene="blpU"
                     /locus_tag="VVR18_002237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HEU6033664.1"
                     /translation="MDTKMMSQFSVMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQ
                     LGIKTGTWQGAATGAAGGAILGGVAYAATCWW"
     gene            799..918
                     /locus_tag="VVR18_002238"
     CDS             799..918
                     /locus_tag="VVR18_002238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="HEU6033665.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDNLIRKIFSKFPKKDTDSTP"
     gene            1215..1379
                     /locus_tag="VVR18_002239"
     CDS             1215..1379
                     /locus_tag="VVR18_002239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033666.1"
                     /translation="MKKKILIIFVLYLIMSIFLYPLRESAWYQLFYTIAYVIAVMIYF
                     AINKKKGEKK"
     gene            1376..1780
                     /locus_tag="VVR18_002240"
     CDS             1376..1780
                     /locus_tag="VVR18_002240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000846948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HEU6033667.1"
                     /translation="MKTFLAKKRNIFLARLFLGQLPLLVSTYLFLSRQFLNFSVVFQF
                     LLVVINLASILVTVYLTREMRIREFEDDDLVSPRTNQLMFIGLTGFMSIICLYRGITA
                     GESYQQLIAYIGAVLCLIIMLLLMWGLKYYKK"
BASE COUNT          578 a          238 c          386 g          634 t
ORIGIN      
        1 aatagtatag taaaactttt tattgcaagg agaataacga aattaagata ttttagatac
       61 tcaagattat tgaaatctta gactaaaaaa taggtactgc tacctttaag aagatagtag
      121 acgtgtatac ttttttaaga aaatcaaaaa gatactataa aaaatctatt tgtttattga
      181 atttaagact ttggtaacaa attgaaaata aaaaggaggt attcatcatg aatacaaaaa
      241 tgttgtcaca gttagaggtt atggatactg aaatgcttgc gaaagttgaa ggggggtata
      301 gctccactga ttgtcaaaat gcactgatta caggagtcac tacgggaatt ataactggtg
      361 gaactggagc aggtttggcc actttaggag tagctggact tgctggtgca tttgttggag
      421 cacacattgg tgcaattggg ggtggattaa catgcttagg aggtatggtt ggtgataaat
      481 tgggactaag ttggtaagac ttatagtaaa attatgagga ttctattctg atttatttta
      541 gttttttaaa aaaggagtat ttgtcatgga tacaaaaatg atgtcacaat tttctgttat
      601 ggatactgaa atgcttgctt gcgttgaagg tggcggatgc aattggggag attttgccaa
      661 agcaggtgtt ggaggaggag cagcaagagg tcttcaacta ggcattaaaa caggaacatg
      721 gcaaggtgca gcaactggtg ctgcgggtgg agctatactt ggaggtgtag cctatgcagc
      781 aacatgttgg tggtaattat ggattttaaa agttttatta ttggtttagt agttggtata
      841 tttggtcctt atatggataa tttaattaga aaaatatttt caaaatttcc caaaaaggat
      901 acagatagta ccccctaaaa aataaatttc tcccctgtat ttgctagctt aatttacagg
      961 ggagtttctt taattttgtt tcgcctgtca aaatgatatg tgatagcagg atgaaaagtc
     1021 tgcaaacaag ttggtatcaa tacaatataa agaggaaagt atgtttttca tgcttgcttt
     1081 tttaattttt acaattcaag aggttttgat gaccatttat gatttgagtg atccaaggtc
     1141 aaaataagtg ctatactagc agtgtaaatg ttcttgctca actaagataa atcgcacatt
     1201 taggaggaaa tcttatgaag aaaaaaatac tgattatttt cgttctgtat ctaatcatgt
     1261 ccatctttct atatccgctt agggagagtg cttggtatca gctattttat accatagcct
     1321 atgtgattgc agttatgatc tattttgcta tcaataaaaa gaaaggagaa aagaaatgaa
     1381 aacttttctt gctaaaaaac ggaacatctt ccttgcgaga ttgttcttag gtcagttgcc
     1441 cttgcttgtt tctacttatc tatttctatc tcgtcagttt ttaaattttt ccgtagtttt
     1501 ccaatttctt ttagtagtta ttaacttggc ttctattttg gttactgttt atctcactag
     1561 ggaaatgagg ataagagagt ttgaagatga tgatttggtt agtcctagaa ccaatcaact
     1621 tatgtttatc ggcttgacag gttttatgtc tattatttgt ttgtatagag gtatcacagc
     1681 aggagaatct tatcaacaac taatcgctta tattggcgct gttctctgct taatcatcat
     1741 gcttctgctc atgtggggct tgaagtatta taaaaagtag agcttaatga agtataaaag
     1801 aaaagggtaa gtgtttttgc aatacttacc ctttta
//
LOCUS       DAVHSO010000126         1807 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.127, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000126 DAVHSO010000000
VERSION     DAVHSO010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1807)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.127"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..973)
                     /locus_tag="VVR18_002241"
     CDS             complement(<1..973)
                     /locus_tag="VVR18_002241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="HEU6033668.1"
                     /translation="MNIAVIGLGHVGLAYALLFASKYKVVAYDIDSVKINNLKKGILP
                     SKNEELMKFFCENNLNITFFDTFSEIKNNIDYYIIALPTDYDEKIGSFNTYEIEQTVS
                     KILRVKPNGKIILKSTVPIGFSNKLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVV
                     GDETVEGRKIAELFLSISTHSTANIKNVMLVSPTEAEAIKLFSNTFLALRVAFFNELD
                     SFAERRSLNAEVVIKGVCLDPRIGNFYNNPSFGFGGYCLPKDTKQLKKEFIEINAPVI
                     EAIDISNTNRKQFIVKQILERKPKIVGIYKLGMKYNSDNYKESAILSI"
     gene            complement(986..1735)
                     /locus_tag="VVR18_002242"
     CDS             complement(986..1735)
                     /locus_tag="VVR18_002242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HEU6033669.1"
                     /translation="MSNNTKYIFLSPHLDDAIFSCGDYISKLTSEGEIVLVITIFSGY
                     PLSQQLQPSAKQFHKLCNLGKYPIEERKKEDRLACERLQCDFRHLSYYECLYRKDRNG
                     NFLYRHIYSELKNEDTLKNDIIKELLMHLDDKCVVYCPLSLGDHVDHVFVNSIGRALE
                     FMRYKVIYYEDFPYVSDSSMVSYMGKTKELKMYQEELDEKHYIDRISSILCYKSQILI
                     IWKSVEKLLNNIKELYLRNGAAYSIRFWIKK"
BASE COUNT          620 a          333 c          209 g          645 t
ORIGIN      
        1 ttatacttaa aatagctgac tctttgtaat tatctgaatt atatttcatc cccaatttat
       61 atattcctac tatctttggc tttcgttcca atatttgttt aactatgaac tgttttctat
      121 ttgtgtttga aatatcaatc gcttctatca ctggggcatt tatttctata aattcttttt
      181 ttaattgttt agtatctttg ggaagacaat atcctccaaa tccaaaagaa ggattattat
      241 aaaaatttcc aattcttgga tctaaacaaa caccttttat tacaacttca gcatttaaac
      301 ttctcctctc agcaaaagaa tctagttcat taaaaaaagc aacacggaga gctaagaatg
      361 tgttagaaaa aagcttaatt gcttctgctt cagtaggaga aactaacata acatttttaa
      421 tattggcagt actatgagta ctaatcgaaa ggaacaactc tgcaattttt cttccttcaa
      481 ctgtctcatc tccaacaact atgcgacttg gatataaatt atcatatata gaacaacctt
      541 ctctcaaaaa ttcagggaca aaaatgatat tttttgtatc aaacagcctt tttaatttgt
      601 ttgaaaagcc gatcggaact gttgacttta aaataatctt tccattaggt tttaccctca
      661 gaatcttcga taccgtttgt tcgatttcat atgtattaaa actaccaatt ttctcatcat
      721 aatctgtcgg aagcgcaata atataataat caatattatt tttaatttca gaaaatgtat
      781 caaaaaaagt aatatttaag ttattctcgc aaaaaaactt cataagctct tcatttttag
      841 atggaagaat gccctttttt aaattattta tttttacaga atctatatca tatgcaacaa
      901 ctttatattt agatgcaaat agtaacgcgt aggccagccc aacatgcccc aaaccaatta
      961 ctgctatatt cataaaacta cttccttatt tcttaatcca aaatctaata gaataagctg
     1021 ccccattcct taaatacaac tctttaatat tgtttaaaag tttttcaact gatttccaga
     1081 ttatcaaaat ctgagattta tagcacaata ttgatgatat tctatcaata taatgttttt
     1141 catcaagttc ctcttgatac atttttaatt ctttagtttt tcccatataa ctaaccatac
     1201 tactatcact tacatatggg aagtcctcat aatatattac tttataacgc ataaattcaa
     1261 gcgcccttcc aatactattc acaaaaacat gatcaacatg gtcaccaagt gaaagcggac
     1321 aatatacgac acatttgtcg tctaaatgca ttaacagctc ttttatgata tcattcttta
     1381 atgtgtcctc attttttaat tcactataga tatgacggta tagaaaattg ccatttctat
     1441 ctttcctata gagacattca tagtacgata agtgtctaaa atcacattgt agacgttcac
     1501 aagctaacct gtcttctttc ttcctttctt caatcggata tttcccaagg ttacacaact
     1561 tatgaaattg cttagcagag ggctgtagct gttggctcaa agggtaacca gaaaatatag
     1621 taataacaag tacaatttct ccttctgaag ttaattttga aatataatca ccacaggaaa
     1681 aaattgcgtc atctaaatgt ggagataaaa agatatactt agtattgtta ctcataacca
     1741 ttccctctac aatttatcta aaaactcact aagtgtctga ttaaattcca catcatcaaa
     1801 aaaattc
//
LOCUS       DAVHSO010000127         1716 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.128, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000127 DAVHSO010000000
VERSION     DAVHSO010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1716)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.128"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            81..971
                     /locus_tag="VVR18_002243"
     CDS             81..971
                     /locus_tag="VVR18_002243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033670.1"
                     /translation="MDNTKVIEWLNYCDQNDIKPWLWDFKNCYSSELTADNISNFLKY
                     KNGELVNPSTFCITKQVGSNADCDKEALPLYNVLGWQHSERDIIRGETLNSYITTFTQ
                     AITNDPNYKEICKKIGVNLNEYLNKQYPILHHNKNYQNFKMIQKNLKEFEAFAKLTHT
                     IGNFTVLPHWMNTGRYNFSKDYWDITMLSLQEWLTNLSPQAWKNFIDTYYLQPYVDNN
                     YQTEVFWETHNYEYIYPKKTEDFSIFLKRVNERIEERGKFIIKQICDKLNKKDFHFYK
                     EIENMDKIKYSNEFEQERKQ"
     gene            968..1438
                     /locus_tag="VVR18_002244"
     CDS             968..1438
                     /locus_tag="VVR18_002244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033671.1"
                     /translation="MTRVYKSVRLAYEAKVWIDELIQEKERKIQELNKEDFLDKLEKT
                     LLKNHYDELNGLSFNIILKASIGSVIEESYRNTKHYPIDKWQKLRQQMERDVKNVNPN
                     LETTVTPRIYLDEDVLAGLDDFRYVLMKEDCATRLPRLSYIIKLVVYSYWKEQH"
BASE COUNT          664 a          270 c          257 g          525 t
ORIGIN      
        1 tctaaatctc ttgcattttc tgaaaaaata gttataataa aagtatagtt gttttacaac
       61 aaaatagaat aggtagaatt atggataaca caaaagttat tgaatggtta aattactgtg
      121 accaaaacga tatcaaacca tggttatggg attttaaaaa ttgttactct agcgagttaa
      181 ccgcagataa tatttcaaat tttctaaaat ataaaaatgg agaactcgta aatccttcca
      241 cattttgtat cacaaaacag gttggtagta acgctgactg cgataaagag gcactcccac
      301 tttataatgt tttaggttgg caacattccg agagagatat aataagaggt gagaccttaa
      361 attcttatat aactacattt actcaagcta ttaccaatga cccgaattat aaagaaattt
      421 gtaaaaagat tggagtaaac ttaaatgaat atctaaacaa gcagtatcca atcttacacc
      481 ataataaaaa ctatcaaaat ttcaagatga ttcaaaaaaa cctaaaagaa tttgaagcat
      541 tcgcaaaatt aacacataca atcggaaact ttactgtatt gcctcattgg atgaatactg
      601 gacgatacaa tttctcaaaa gattactggg atattacaat gctttctctt caagaatggc
      661 ttactaattt atctcctcaa gcatggaaaa attttattga tacatactat cttcaaccct
      721 atgttgataa taactatcaa acagaggtat tttgggaaac tcataactac gaatacattt
      781 atcccaagaa aaccgaagat ttctccatct tcctaaaaag agtcaatgaa cggattgagg
      841 agcgcgggaa attcatcatt aaacaaatat gcgataaact aaataaaaaa gatttccatt
      901 tctataagga aattgaaaat atggataaaa ttaaatactc aaatgaattt gaacaagaga
      961 ggaaacaatg actagagtat ataaaagcgt ccgccttgcg tacgaggcaa aggtatggat
     1021 agatgaattg attcaagaaa aagaacgtaa aattcaagaa cttaataaag aggattttct
     1081 agataaactt gaaaaaacac ttcttaaaaa tcactatgat gaattgaatg gtctttcatt
     1141 taatatcatt ctaaaagcct caatagggag tgtcatagaa gaatcctatc gaaatactaa
     1201 acactatcca attgacaaat ggcaaaagct acgtcagcag atggaaaggg acgtaaaaaa
     1261 tgttaatcct aacttagaaa ccacagttac tccccgtatt tatctagacg aggatgtgct
     1321 tgctgggctt gatgattttc gctatgtttt gatgaaagag gactgtgcta ctagactacc
     1381 tcgtcttagc tacattatca aacttgttgt atattcctac tggaaagaac aacactaatc
     1441 taatcagttc tactgtttag attttcattt ctttaaaatg tatatttgtt gtactactaa
     1501 taaatctaga aaaataggta atctatgttt aaattaaaga aagtcgctga cttaaaaaga
     1561 aattatatca tttcaactaa caaattaaag gtaactcatt ggtcaatatt aagcctctct
     1621 atctgcatta tgcttactat tattgcaaat attagagccc ctgaccttat taaaatccct
     1681 ttacttattc tagtaggatt tgtcatatac aaattt
//
LOCUS       DAVHSO010000128         1686 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.129, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000128 DAVHSO010000000
VERSION     DAVHSO010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1686)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.129"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            145..>1686
                     /locus_tag="VVR18_002245"
     CDS             145..>1686
                     /locus_tag="VVR18_002245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HEU6033672.1"
                     /translation="MEENYNLSITQIKNSIKENSLVLFVGAGISANSNLPTWGELIQS
                     LKKELNIPEERTDSPLRIAQYYYDTFGKNQYTKKIEEIFFKKGLSKPNELHKLIEKIA
                     PKHIITTNYDSLLESQFESGLLKYNVVAEDKDIPYTSSERYLIKMHGDFSKKNIVLKE
                     DDYLDYHLNFPMISTLIQSLIMNHTLLFVGYSLSDSTFNSIFRMIQNTFKLDAKNAYF
                     YTPEEPSMIIREYYKKQGIFIISNEENLGQETSEKQNKLYCRTKDFLEVLSENRSQDV
                     NNADDLWNQLAFLDRLSFIDAKDFSRYSDLKKRALNWDDEYCWFGNDQLRFEIDGHEE
                     LRIMVSKKSLLNRFLDMEIGEPRDLKGNRFLSKAFKLYEEKQYSLAKAKFRELANIAF
                     RQKDYFNFLVCEFNFQQIQIIDRYEKTPSYAEPLYDGELSELTEQIINSVTGDEKKII
                     EFFRDSILNFNFLYRKLETINELFDEIREEHESYRRGGWSANNHLFNAEFTVKNLYNF
                     LKLNCL"
BASE COUNT          654 a          183 c          289 g          560 t
ORIGIN      
        1 atcataaatt gaatataaaa gacaaataaa tttttatatt tataaaccat gataaacttt
       61 tgtttaagat tatgtaataa aaaagaagat ttataaggat aatttgtatt tatgtagtac
      121 aagctaatgt aggatagtta aaatatggaa gaaaattata atttatctat aactcaaata
      181 aagaattcta ttaaagaaaa ttccttagtt ttgtttgttg gtgcaggaat atcagctaat
      241 tctaatctac caacttgggg agaattgatt caatcattaa aaaaagaatt gaacatacca
      301 gaagaaagaa cagatagtcc actgagaatt gctcagtatt attatgatac ttttgggaaa
      361 aatcagtaca caaagaagat agaagaaatt ttctttaaga agggattgag taaaccaaat
      421 gagttacata aattaataga aaaaattgca ccaaaacata ttattacgac aaactatgat
      481 tcacttctgg agagtcaatt tgaaagtggc ttgttaaagt acaatgtagt cgctgaggat
      541 aaagacatcc cttatacgag ttcggaaaga tacttgatta aaatgcatgg tgacttcagt
      601 aagaaaaata ttgttttgaa agaagatgat tatttagact atcatttgaa cttcccaatg
      661 atttctactt taatccagtc attgataatg aatcatactc tattgtttgt ggggtattct
      721 ctaagtgatt cgacttttaa ttcaattttt agaatgattc aaaatacatt taaattggat
      781 gctaaaaatg cttattttta tactcccgag gaaccgtcta tgatcattcg agagtattat
      841 aagaagcaag gaattttcat tatctctaat gaagagaatc taggtcagga gacatcagaa
      901 aaacagaaca aattgtattg caggacaaaa gattttttag aggttctatc agaaaaccga
      961 agtcaagatg taaataatgc tgatgattta tggaatcaac tggctttttt agatagactt
     1021 agttttattg atgcgaaaga tttttctaga tattctgatt taaagaaaag ggctttaaac
     1081 tgggatgatg agtattgctg gtttggaaat gatcaattaa gatttgaaat tgatggtcat
     1141 gaagaattac gaattatggt atctaaaaaa tctttattaa atcgctttct agatatggag
     1201 attggtgaac ctagggattt aaaggggaat cgattcttaa gtaaggcttt taagttgtat
     1261 gaagaaaaac aatattcttt agcaaaagca aaatttagag aactagctaa tatagcattt
     1321 cgtcagaaag actattttaa tttcttagtt tgtgaattta attttcagca aattcaaata
     1381 attgatagat acgaaaaaac acctagttat gcagagccac tttatgatgg agaattaagc
     1441 gaattaacag aacaaattat taactcggtt acaggagatg agaaaaagat tatagaattt
     1501 tttagagatt caatccttaa cttcaatttt ttatatagaa aattagaaac tattaatgaa
     1561 ttatttgatg aaattcgtga agagcatgaa agctatagaa gaggaggatg gtctgctaat
     1621 aatcatctat ttaatgcgga gtttacagta aaaaatcttt ataacttttt aaaattaaat
     1681 tgttta
//
LOCUS       DAVHSO010000129         1650 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.130, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000129 DAVHSO010000000
VERSION     DAVHSO010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1650)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.130"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(145..345)
                     /locus_tag="VVR18_002246"
                     /pseudo
     CDS             complement(145..345)
                     /locus_tag="VVR18_002246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(433..807)
                     /locus_tag="VVR18_002247"
     CDS             complement(433..807)
                     /locus_tag="VVR18_002247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000213831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033673.1"
                     /translation="MTTSYLKSKSDNGGGTYCLDNIELLANIDFIKIFEEISTSSKID
                     IVTYSFYDDEFLKALLYDKINVRVLLSKISNQSQHYTDLIREIVPNSEVIQVEETHAK
                     IVLAEPNFVYLGSQNIDQSDWF"
     gene            complement(950..>1650)
                     /gene="phtB"
                     /locus_tag="VVR18_002248"
     CDS             complement(950..>1650)
                     /gene="phtB"
                     /locus_tag="VVR18_002248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtB"
                     /protein_id="HEU6033674.1"
                     /translation="HQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNLQYTVEVKNGS
                     LIIPHYDHYHNIKFEWFDEGLYEAPKGYSLEDLLATVKYYVEHPNERPHSDNGFGNAS
                     DHVQRNKNGQADTNQTEKPSEEKPQTEKPEEETPREEKPQSEKPESPKPTEEPEEESP
                     EESEEPQVETEKVEEKLREAEDLLGKIQDPIIKSNAKETLTGLKNNLLFGTQDNNTIM
                     AEAEKLLALLKESK"
BASE COUNT          447 a          302 c          261 g          640 t
ORIGIN      
        1 acttaaaaaa gtaaaaaagc taaaaatact ccaataatta ttttaaaatt cttcttcctt
       61 tctttttaag ggttttcatt tttctatgtt ttaaataaat aggatattaa aaatcgaact
      121 catattatta tacttcctgc gaaactaaaa tcctagttca cggttgataa ttccagcaat
      181 caaattcatt cgtaatccaa agcgtttacg tcgatttcga taggttgttg aaaacatttt
      241 aaacgttttt actttggcaa aaatattctc aaccttgatt ctctctttag atagcacatg
      301 gttataggat ttatcttcaa gagttagtgg cttaagttta cttgattcat aattcatagt
      361 tttattgtat tatatttttg tttcgcagga agtctattta taaatttctt ggtctctaat
      421 aactacgctt gtctagaacc agtctgattg atcaatattt tgggacccta gatatacaaa
      481 attaggttca gccagaacga ttttagcgtg agtttcttcg acttgtatca cctctgaatt
      541 aggtacaatc tctcgaatta aatctgtgta atgttgactt tgattagaga ttttacttaa
      601 taggactctg acattgattt tatcatagag tagagctttt aaaaattcat catcataaaa
      661 actataagta acgatatcga ttttagaaga agtagaaatt tcttcaaata ttttgataaa
      721 atcaatattt gctaacaatt ctatattgtc taaacagtaa gtgcccccac cattatcaga
      781 tttagatttt aaataagatg ttgtcataac ttttacaccg tttccctttc aattttataa
      841 atctatcatt ttcatgaaaa aaatgagaac tagaactcac attctgctct catttttcgt
      901 tttcccgttc tcctatcctg tttttaggag ttagaaaatg ctgctacctt tacttactct
      961 cctttaataa agccaatagt ttttcagctt ctgccataat agtattgttg tcctgggtgc
     1021 caaatagtaa attatttttt aatcctgtga gagtctcttt ggcattggac ttgataattg
     1081 gatcctggat ttttccaagt aaatcttcag cctctctcag tttttcttca accttttcag
     1141 tctcgacctg aggttcttct gattcctctg gtgattcttc ttctggttcc tctgttggtt
     1201 ttggagactc tggtttctcg ctttgcggtt tctcttctcg aggggtttct tcctcaggtt
     1261 tttctgtctg aggtttctcc tcgcttggtt tttccgtttg attggtatca gcttgaccat
     1321 ttttgtttct ttgaacatgg tcgctagcgt taccaaaacc attatctgaa tgcggacgtt
     1381 cgtttggatg ttcgacatag tacttgacag tcgccaaaag atcctcaaga ctatacccct
     1441 taggtgcctc ataaaggcct tcgtcaaacc actcaaattt gatgttatgg taatggtcat
     1501 aatgaggtat gattaaacta ccgtttttga cttctacagt atattgaaga ttgtaaggca
     1561 tacgatcaag tggcaccttc ttagctgctt tcacgcggtt gtagatagct tctgctcctt
     1621 ttgcctcagt atttcctgaa tcctgatgtt
//
LOCUS       DAVHSO010000130         1529 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.131, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000130 DAVHSO010000000
VERSION     DAVHSO010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1529)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1529)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1529
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.131"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(107..1396)
                     /locus_tag="VVR18_002249"
     CDS             complement(107..1396)
                     /locus_tag="VVR18_002249"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HEU6033675.1"
                     /translation="MKLQKPKGTQDILPAESAKWQYVEGFAREIFKRYNYAEVRTPIF
                     EHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQK
                     PSKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSSNPATDVETIVMAAHFLKEIGIQG
                     VKLHLNTLGNPESRAAYRQALIDYLTPLKETLSKDSQRRLEENPLRVLDSKEKEDKVA
                     VENAPSILDFLDEESQTHFDAVRQMLENLGVDYIIDTNMVRGLDYYNHTIFEFITEIE
                     GNDLTVCAGGRYDGLVAYFGGPETAGFGFGLGVERLLLILEKQGVALPIENALDVYIA
                     VLGDGANVKALELVQALRQQGFKAERDYLNRKLKAQFKSADVFAAKTLITLGESEVES
                     RQVTVKNNQTREEVQVSLETISQNFSEIFEKLGFYTQ"
BASE COUNT          404 a          359 c          327 g          439 t
ORIGIN      
        1 acaacctcaa aaccatgttt tgagctgact tcgtcagttc tatccacaac ctcaaaacag
       61 tgttttgagc aacctgcggc tagcttccta gtttgctctt tgatttttat tgagtataaa
      121 atcctagttt ttcaaagatt tctgagaagt tttggctgat tgtctcaagt gacacttgca
      181 cttcttctcg ggtttggttg ttcttgactg tcacttgtct gctttcgact tcgctctctc
      241 ctagggtgat gagggtctta gccgcaaaga catcggctga cttgaactga gctttgagct
      301 tacggttgag gtaatcacgc tctgctttga aaccttgttg gcgaagagct tggactagtt
      361 ctagggcttt gacatttgct ccatcaccca agactgcgat atagacatct agggcatttt
      421 cgatagggag ggccacgcct tgtttttcaa ggatgagaag caggcgctct acaccaagcc
      481 caaaaccaaa tccagcagtt tcagggcctc caaagtaagc aaccaaacca tcgtagcgac
      541 cacccgcaca gactgtcaag tcattgccct caatctctgt gataaactcg aaaatggtgt
      601 ggttgtagta gtccagacca cgcaccatat tggtatcgat gatgtaatct actccaagat
      661 tttccaacat ctgacgcaca gcatcaaaat gagtttggct ttcttcatca agaaagtcca
      721 agatagacgg cgcattctct actgccacct tgtcttcttt ttccttagag tccaagacac
      781 gaagaggatt ttcctccaag cgacgttggc tatccttaga caaggtctcc ttgagcggtg
      841 tcaaatagtc aatcaaggct tggcggtagg ctgcacggct ctcaggattt ccaagagtgt
      901 tgaggtgcaa tttgacacct tgaataccga tttccttcaa aaaatgggct gccataacga
      961 ttgtttccac atcggtagct ggattgctag agccaaaaca ctcaacacca atctggtgga
     1021 attggcgcaa gcgccctgcc tgtggacgct cataacggaa cataggtccc atgtagtaga
     1081 acttgcttgg cttttgcact tctggggcga agagtttatt ttccacatag gaacggacaa
     1141 cgggcgcagt tccttctgga cggagggtaa tatgacggtc acccttgtca taaaaatcgt
     1201 acatttcctt ggttacgata tctgttgtat ctccgacaga gcggctgata acctcgtaat
     1261 gctcgaaaat aggcgtacgc acttctgcgt agttgtagcg cttgaaaatt tcacgggcaa
     1321 agccctcaac gtactgccat ttggcagatt cagcaggtaa aatatcctgc gttccttttg
     1381 gtttttgtaa tttcataggg aatcctcttt aaacttaata gtcttatttt accacaaata
     1441 aagggattaa aacagtgaga aaaaaattag gatttaaccc aaatcattca tacctctctc
     1501 aactagatgt aacttacaaa acccctgac
//
LOCUS       DAVHSO010000131         1520 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.132, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000131 DAVHSO010000000
VERSION     DAVHSO010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1520)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.132"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..201)
                     /locus_tag="VVR18_002250"
     CDS             complement(<1..201)
                     /locus_tag="VVR18_002250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033676.1"
                     /translation="MAYSIDFRKKVLSYCERIGSITEASHVFQISRNTIYGWLKLKEK
                     TGELNHQVKGTKPRKVDRDRLKN"
     gene            278..733
                     /locus_tag="VVR18_002251"
     CDS             278..733
                     /locus_tag="VVR18_002251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU6033677.1"
                     /translation="MQWQTQLSEKKANTDYIARYGVHAVIPNPEQKQIVLVQEPNGAW
                     FLPCGEIEAGENHQEALKRELIEELGFTAEIGTYYGQADEYFYSRHRDTYYSNPAYLY
                     EATPFKEVQKPLENFNHIAWFPIDEAIKNLKRGSHKWAIESWQKQHKIG"
     gene            898..1197
                     /locus_tag="VVR18_002252"
     CDS             898..1197
                     /locus_tag="VVR18_002252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1827 family protein"
                     /protein_id="HEU6033678.1"
                     /translation="MKLINTTNSHSQLVKSQLESTDATLVEVYSAGNTDVIFTQAPLH
                     YEILISNKHRAIREPEIETIQEFFLKRKIDKTSVDEANIKTLYSEKLIGISIPIK"
BASE COUNT          511 a          295 c          259 g          455 t
ORIGIN      
        1 gtttttaagt ctatctctat caacttttct tggttttgtt ccttttactt ggtggtttag
       61 ctctcctgtt ttctctttta gctttaacca gccataaatg gtattacgtg agatttggaa
      121 aacgtgtgat gcttctgtta tactacctat tcgctcacaa taagagagaa cttttttacg
      181 aaaatctatt gaatatgcca taagaagatt ataccacatt gtgtactatt tttggttcat
      241 ttcactataa taataacgat actagataat gaggaaaatg caatggcaaa cccaactttc
      301 ggagaaaaaa gcgaatacag actatattgc tcgctatggc gtacatgcag ttatccctaa
      361 tcctgaacaa aaacaaattg ttcttgttca agaaccaaat ggtgcttggt tcctaccatg
      421 tggagaaatt gaagcaggtg aaaatcatca ggaagcccta aagcgtgagt tgattgaaga
      481 gcttggtttc acagcagaaa ttggtaccta ttacggacaa gctgacgaat atttctattc
      541 tcgtcatcgt gatacctact actccaatcc tgcctacctc tatgaagcaa ctcctttcaa
      601 agaagtacaa aagccactag aaaactttaa tcatattgcc tggttcccta ttgacgaggc
      661 tatcaaaaac cttaaacgtg gtagccataa atgggccatt gaatcttggc aaaaacagca
      721 taagattggc taatactctt cgaaaataaa attcaaacca cgtcagcgtc gccttaccgt
      781 actcaagtat agcctgcggc tagcttccta gtttgctctt tgattttcat tgagtataaa
      841 tcaagcgact ttattcaaaa agtgctataa tagaattaga aaatcggagg aaatattatg
      901 aagcttatca atacgacaaa ctcacactcg caacttgtaa aaagtcagct agaaagtacc
      961 gatgcaaccc ttgttgaggt ttattctgca gggaatacag atgttatttt tacccaagct
     1021 ccgcttcact atgaaatcct catctcaaac aaacaccgtg ctattcgtga gcctgaaatc
     1081 gaaaccattc aagaattttt cttgaaacgt aaaattgata agacctctgt tgatgaagcc
     1141 aatatcaaga cactctactc agagaaatta attggaattt caatcccaat caagtaagaa
     1201 aattgagtaa aaactcgatt tgagagaaag tccaataagt ctttccataa caaaacgcat
     1261 agtaacaaga gtttctacac ccactattat gcgtttttat cattttgaaa tctactgcta
     1321 atcaatgaag aagcaaagat caaactaggc agctagttac aagttacgta agcgcgtcat
     1381 aacaaggtat ctatcctaat tccccaactt ccagtatact agataaaaaa taattatcgg
     1441 aggaaaggta ttgtactatg ataattcaac taagtgattt aggtcaagtt caccttgttt
     1501 gtggtaagac agatatgagg
//
LOCUS       DAVHSO010000132         1492 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.133, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000132 DAVHSO010000000
VERSION     DAVHSO010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1492)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.133"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            186..1235
                     /locus_tag="VVR18_002253"
     CDS             186..1235
                     /locus_tag="VVR18_002253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033679.1"
                     /translation="MIELKIGKPSFGFLPYESHIEGILTGNNLNKIDYYLSMLDMEAI
                     CLQYGNKRIYDFFIGRNIQCNNIYREYSSRIDLSSEEALIPFLVDALAKGSFCYLSVD
                     TFCINKYISYKKEHIVHSPLVSGIDLDRNLIKISDFFDFTNYGIVWVPINEFIKGYFA
                     IQKVVEEGDIEETENWILKIEKINICKNKTEICDRMAINKVFKGYVLGSEEVKDSMDT
                     FSYINYRLANHKVFQKQSIVEQNLSVTGIKVYEYLKLYIEESIKEPQVLMRIKNLVLL
                     KKHFDVYKKIVQVLGINSEKVQACIEKAQLFLLIGMKINRSNQINNKLYFDMISIVRE
                     LKEMEYEIISEILSM"
BASE COUNT          568 a          123 c          275 g          526 t
ORIGIN      
        1 aataaattgt taaaaaggac gaattcatct tggttagtct ctaaatttat attattgcgt
       61 taatcaggta taagtttttg cataatataa gaatagttgt gaattaaagc aggaatgatg
      121 acagaaatta tgtcaatttg agtttagttc gatgaaagta aatttatatt aggagattta
      181 taaaaatgat tgaattaaag attggaaaac caagttttgg ctttttgccc tatgaatcac
      241 atattgaagg aattcttaca ggaaataacc taaataaaat tgattattat ttatccatgc
      301 tggatatgga agcgatatgt cttcaatatg gtaataagag aatttatgat tttttcattg
      361 gaagaaatat acaatgtaat aatatataca gagagtattc gtcacgtata gatttatcta
      421 gtgaggaagc tttaatccct tttttggttg atgcgttagc taaaggttct ttttgttatt
      481 tatcagtaga tacattctgt attaataagt atattagtta taaaaaggaa catattgtgc
      541 attcaccttt ggtttcagga attgatttag atagaaacct gataaaaata tctgactttt
      601 ttgattttac aaattatgga attgtttggg ttcctataaa tgagttcatt aaaggatatt
      661 ttgcaattca aaaggtggtg gaagaaggtg atattgaaga aacagaaaac tggatactga
      721 aaatagaaaa aataaatata tgtaaaaata aaacagaaat ttgtgataga atggcgataa
      781 ataaagtttt taaaggctat gttttgggtt cagaagaagt gaaggattca atggatacat
      841 ttagttatat aaattatagg ttagctaatc ataaggtttt tcagaaacag agtatagtag
      901 agcaaaatct tagtgtgaca ggaataaaag tatatgaata tttgaaactt tatattgaag
      961 aaagtattaa agaacctcaa gttctgatga gaattaaaaa tcttgtatta ttaaaaaaac
     1021 attttgatgt ttataaaaaa atagttcaag tgttaggtat taactctgaa aaggtgcaag
     1081 cgtgtattga aaaggctcag ttgtttttgc taattggtat gaaaataaat agatctaatc
     1141 aaatcaacaa taaattatac tttgatatga ttagcatagt aagggaatta aaagaaatgg
     1201 agtacgaaat tatcagtgag attttgtcaa tgtaaaatat tgaattttta agagaaatct
     1261 ttggaatcta atagtggatt tttgaaagat aattcgaaga tataagatta gattttttta
     1321 gaaggattat agagccatgg ggaacctctc tctaaatctg tagttttgtg atttgggacg
     1381 aggtaataaa agaagcaaat tagaaaagtc aaaaagttca cttttgtagg cttttttgta
     1441 ctttaattat attgagattt aactgtattt tggaaaaata tttctattag tg
//
LOCUS       DAVHSO010000133         1438 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.134, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000133 DAVHSO010000000
VERSION     DAVHSO010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1438)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.134"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(1..520)
                     /locus_tag="VVR18_002254"
                     /pseudo
     CDS             complement(1..520)
                     /locus_tag="VVR18_002254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007897432.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(596..1342)
                     /locus_tag="VVR18_002255"
     CDS             complement(596..1342)
                     /locus_tag="VVR18_002255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033680.1"
                     /translation="MKRNKIWKKTLTYPVEREEITYKRKKSKGKRQALLAQFDSEEVY
                     HQVEESIYPDCQGDLKEIGATLQRQELVFIPAQLKRIDHIQHAYKCQACSDKNPSDKI
                     VKAPIPKAPLAHSLGSASIIAHTIHQKFNLKVPNYRQEEDWAKMGLPITRKEIANWHI
                     KASQYYLEPLYNLLREKLLEQALLHADETSYRVLESDSQLTYYWIFLSGKAEKQGITL
                     YHHDQCRSGSVVQEFLGDYSGYVHCDMLRQ"
     gene            complement(1296..>1438)
                     /locus_tag="VVR18_002256"
     CDS             complement(1296..>1438)
                     /locus_tag="VVR18_002256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033681.1"
                     /translation="ALLREQVAYLTQKLYGKSSEKSVCPSGQLSLFEEEQNMEEDSDL
                     PS"
BASE COUNT          394 a          315 c          279 g          450 t
ORIGIN      
        1 ataataatag ctcttgcttt agctccttca aaactttgag aaaataacca ccctcgcttt
       61 tttaaactga gctcaggcta aaagagtcca ctggactctt ttactccgtc ccataaccaa
      121 tgatttaatg gcgcgttcag ctagattatt ggaaaggacc agatggtccg tctttcaaaa
      181 tagtcttaaa ggtttcttca tacttgaggc tgtattcaat tgcccttcct agttttgaac
      241 ctgctaaaac tgactgacgg cggcaccaag caaagaagtc ttccattagg ggctggagat
      301 gttcttgacg tttctgtagt cgttcatcag ctggcaaagc ctcccagtct ctttccaagg
      361 aaaataactg atcacaataa gctaaacctt tagatcctaa ggatgattta tctgcttgct
      421 tgggggtcgc ttcaaaaaat ttccttctca catgcgccca acatccaaca agttcagctt
      481 cttccagttg acgataagct tctagcggtt cgcagtttac caagcttagc gtcgccttac
      541 tcctaaactt tggactgcta tcgcataggc agaactagag gactaaagtc ctaagttact
      601 gccgcaacat gtcacaatga acatagccag aataatctcc taggaattct tgtactactg
      661 aaccacttcg acactgatca tggtggtaaa gcgtaatccc ttgtttctct gctttacctg
      721 acaaaaaaat ccaatagtaa gtcagctgac tatcactttc tagaacccga taagaggttt
      781 catccgcatg aagaagagct tgttctaaca acttttctcg taaaagatta taaaggggct
      841 ccaaatagta ttgactcgcc ttgatatgcc aattagcaat ttccttacgt gtgattggta
      901 aacccatctt agcccaatct tcttcttggc gataattggg taccttcaga ttaaacttct
      961 gatggatggt gtgagcgata atagaagctg agccaaggct atgcgccaaa ggggctttag
     1021 gaataggagc tttcacgatt ttatcactcg gatttttatc actgcatgct tggcacttat
     1081 aagcgtgttg gatatgatct attcgtttta attgcgcagg aataaagact aattcttgtc
     1141 gttgaagggt tgctccaatc tcttttagat ctccctgaca atcagggtaa atgctctctt
     1201 ctacttgatg ataaacttct tctgaatcaa attgggcaag aagagcttgg cgtttccctt
     1261 tagatttctt acgtttatag gtgatttctt ctctttcaac tgggtaagtc agagtcttct
     1321 tccatatttt gttcctcttc aaaaagactg agttgtccag atgggcaaac acttttctca
     1381 gaggattttc catagagctt ttgcgttaga taagccactt gttcacgaag aagggcaa
//
LOCUS       DAVHSO010000134         1419 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.135, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000134 DAVHSO010000000
VERSION     DAVHSO010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1419)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1419)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.135"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..1310)
                     /locus_tag="VVR18_002257"
     CDS             complement(<1..1310)
                     /locus_tag="VVR18_002257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015898732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory Sec-dependent serine-rich glycoprotein
                     adhesin"
                     /protein_id="HEU6033682.1"
                     /translation="MKSGKHWLRASTSLFGLFKVLRGGVDTTQVMTETVEDKVSHSIT
                     GLDILKGIVAAGAVISGTVATQTKVFTNESAVLEKTVEKTDALATNGTVVLGTISTSN
                     SASSTSLSASESASTSASESASTSASTSASTSASESASTSASTSISASSTVVGTQTAA
                     ATEATAKKVEEDRKKPASDYVASVTNVNLQSYAKRRKRSVDSIEQLLASIKAAVFSGN
                     TTVNGAPAINASLNIAKSERKVYTGTGLDSVYNVPIYYQLTVTNDGLKLTFTYTVTYV
                     DPKTKTLGNISKKMSNGYSIYNTGTSIQTMLTLGSGLGKPSGVKNSITDKNGVLVQFY
                     NISTMTKQGSGYTWANGAQMNGWQAKKGYGLTSSWTVSIIGTDTSFTFTPYAAKTDNI
                     RINYFNGKGKVVESSTTSQSLSQSKSLSVSASQSASASASTSASA"
BASE COUNT          383 a          299 c          272 g          465 t
ORIGIN      
        1 gctgaggcgc tggttgacgc tgaggctgag gcgctttgac tagcacttac tgatagtgac
       61 ttagactgtg aaagtgactg actggtcgtg ctagattcaa ctacctttcc tttaccattg
      121 aagtagttaa ttctaatgtt atctgtttta gcagcataag gggtaaatgt aaaggatgta
      181 tccgttccaa taattgatac agtccaagat gatgttaatc catatccttt cttagcctgc
      241 caaccattca tttgggcacc atttgcccaa gtatacccac taccctgctt cgtcattgta
      301 gatatattat agaattgaac cagtacacca tttttgtcag taatggagtt ctttacacct
      361 gaaggtttac caagaccact gccaagggtt aacattgttt gtattgaagt tcctgtatta
      421 tagatagaat atccattact catctttttt gatatattac caagagtctt tgttttagga
      481 tccacatacg taaccgtata ggtaaaggtc agttttaagc catcatttgt cactgtcaat
      541 tgatagtaaa ttggaacatt atataccgaa tctaaacctg tacctgtata aacttttctc
      601 tcacttttag caatgtttag acttgcatta attgcagggg cgccatttac agtcgtattg
      661 ccagaaaaaa cagcagcttt tatagaagcc agcaattgct cgatggaatc cactgaacgc
      721 ttgcgtcgct tagcataaga ttggagattg acatttgtaa ctgatgctac ataatcacta
      781 gctggtttct tacgatcttc ttcgaccttc ttagcagttg cttctgtagc ggcagctgtt
      841 tgtgttccta ccacagtaga tgatgcagag atacttgtcg aagccgatgt acttgctgat
      901 tctgatgcac ttgtactcgc tgaggtcgaa gcgctggttg aggctgactc agatgcagat
      961 gtacttgccg actctgaagc tgacaaacta gttgaactcg ctgaattact tgtagatatc
     1021 gtacctagaa ctactgtacc atttgttgcc aaagcatccg ttttctctac agttttttca
     1081 agtactgctg actcatttgt aaataccttc gtttgagttg caacggttcc actgatgaca
     1141 gctcccgcag caactatccc cttgaggata tcaagcccag taattgaatg acttacttta
     1201 tcttctaccg tttcggtcat gacctgagta gtatcaacac cacctcgcaa gaccttaaac
     1261 aagccaaaaa gagaagtcga ggcccgtagc caatgcttcc ctgatttgat taatttgaac
     1321 cgagttactc ggtctgtttc tctatattca ctcttctgac gtctaaaaaa tattttgaaa
     1381 tttcctttcg agtattattt tcatgtatgg atataaata
//
LOCUS       DAVHSO010000135         1340 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.136, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000135 DAVHSO010000000
VERSION     DAVHSO010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1340)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.136"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..495
                     /locus_tag="VVR18_002258"
     CDS             <1..495
                     /locus_tag="VVR18_002258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HEU6033683.1"
                     /translation="IVCSSISKSLCAPGLRIGYICANEKIVKKLEKKVIPFNVSNINQ
                     CIAEKILENFPLSLSICSDIESSFRQLDLFMEKYTTQKSEKACGFRLYQLKAKYDGNK
                     IIDILTERGFLIRNISASYPELGENWIRISNGTLSEIKDLMHIMKDIFEDFDDKASDS
                     YDKG"
     gene            538..>1340
                     /locus_tag="VVR18_002259"
     CDS             538..>1340
                     /locus_tag="VVR18_002259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001852388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033684.1"
                     /translation="MKLSSDLNILIRQLSYFIKDKEMLQQKIFGNFLDRFEEAYEQHF
                     FDIFDSLTGGIKISDVDWILGEEKLIKFLGRKNKNGQYLYVLPTNDGYLLRGSETYYH
                     YLSNVPYDYFKLIDKNIFIDGLKSTQNFLTEFIQYINSENSLTLKISLAFLDNLRNQI
                     LILLNAKFLVENDFKHGKYYVNFDSKLFKAIELFYSYYEKLFNFKHFILQPEDLVVIL
                     DILNSEIEALIPKLKNLDNNKVRKLTRVFRELDSIWEIFISLKYFFESE"
BASE COUNT          493 a          152 c          226 g          469 t
ORIGIN      
        1 attgtttgtt cctcaatatc gaagtcacta tgtgctcctg gattaagaat aggctatata
       61 tgtgctaacg aaaaaattgt aaaaaaatta gaaaaaaaag taattccttt caatgtttct
      121 aatatcaatc aatgtatagc tgaaaaaata ttagaaaatt ttccgctctc tctaagtata
      181 tgttcagaca ttgagtcttc atttagacaa ttagatttat ttatggagaa atacactact
      241 caaaagtctg aaaaggcgtg tggtttcagg ttataccagt tgaaagcaaa atatgatggt
      301 aataaaataa tagatatact aacggaaaga ggttttttga taagaaatat aagtgcttca
      361 tatcctgaat tgggtgaaaa ttggataagg attagtaatg gcacgttatc agagattaaa
      421 gatttgatgc acataatgaa agatatcttt gaagattttg atgacaaagc cagtgatagt
      481 tatgacaagg ggtaggtgtt gaaaataaaa gatagtgcgg agattttgaa taataatatg
      541 aaattaagta gtgacttaaa tattttaata aggcaactct cttattttat aaaagacaag
      601 gaaatgttgc aacaaaagat ttttggtaat ttcttagata gatttgaaga ggcttatgag
      661 cagcactttt ttgatatttt tgattcactt actgggggaa ttaagattag tgatgttgat
      721 tggattttag gtgaagaaaa gttgattaaa tttcttggga gaaaaaataa aaatggtcaa
      781 tacctctacg tacttccaac aaatgacggc tatttactca gaggttctga aacatactac
      841 cattatttat cgaatgtacc atatgattat tttaaactca ttgacaaaaa tatatttatc
      901 gatggcttga aatctacaca aaatttttta acggaattca tccaatatat aaattcagaa
      961 aactctttga ctcttaaaat cagtcttgca tttctagaca atttaagaaa tcaaatttta
     1021 atactcttga atgctaagtt tttagtagag aatgatttta aacatgggaa atattatgtg
     1081 aatttcgatt ctaaactatt caaagctatt gagttatttt acagctatta tgaaaagcta
     1141 tttaatttca agcattttat tctgcaaccg gaagatttag ttgtgatcct tgatatttta
     1201 aactctgaaa ttgaagcttt gattcctaag cttaaaaatc tagataataa taaagttaga
     1261 aagcttactc gtgtttttag ggaattagat tctatctggg aaatttttat ttctttaaag
     1321 tatttctttg aaagtgaaaa
//
LOCUS       DAVHSO010000136         1193 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.137, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000136 DAVHSO010000000
VERSION     DAVHSO010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1193)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1193)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.137"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..668
                     /locus_tag="VVR18_002260"
     CDS             <1..668
                     /locus_tag="VVR18_002260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000677523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU6033685.1"
                     /translation="TLIKTLSRLIKPLEGEVLLDNKSINSYKEKDLAKHIAILPQSPI
                     IPESITVADLVSRGRFPYRKPFKSLGKDDLEIINRSMVMANVEDLANNLVEELSGGQR
                     QRVWIALALAQDTSILLLDEPTTYLDISYQIELLDLLTDLNQKYKTTICMILHDINLT
                     ARYADYLFAIKEGKLVAEGKPEDILNDKLVKDIFNLEAKIIRDPISNSPLMIPIGKHH
                     VSS"
BASE COUNT          486 a          191 c          188 g          328 t
ORIGIN      
        1 caacactcat taaaaccttg tctcgactta taaagccatt agagggagaa gtattgcttg
       61 ataataaatc aattaattct tataaagaaa aagatttagc aaaacacata gctatattac
      121 ctcaatctcc aataatccct gaatcaataa cagtagctga tcttgtaagc cgtggtcgtt
      181 tcccctacag aaagcctttt aagagtcttg gaaaagatga ccttgaaata ataaacagat
      241 caatggttat ggccaatgtt gaagatctag caaataacct agttgaagaa ctttctgggg
      301 gtcaaaggca aagagtatgg atagctctag ccctagccca agatacaagt atcctacttt
      361 tagatgagcc aactacttac ttggatatct catatcaaat agaactatta gacctcttga
      421 ctgatctaaa ccaaaaatat aagacaacca tttgcatgat tttgcacgat ataaatctaa
      481 cagcaagata cgctgattac ctatttgcaa ttaaagaagg taaacttgtt gcagagggaa
      541 agcctgaaga tatactaaat gataaactag ttaaagatat ctttaatctt gaagcaaaaa
      601 ttatacgtga ccctatttcc aattcgcctc taatgattcc tattggcaag caccatgtta
      661 gctcttaata attgaatatt ggaattcatt taaaagtcgc aaattttgaa ctgaccctca
      721 aaagttaggc caaaaaacta actaaaggag gtcagttttt taatggcaaa tacagcacag
      781 aatttaagat aaaattagta aaagaatatc atgaatgaaa aataggatat agagaataac
      841 agcaatatta aaaagatcag gactgataat aaacaaaaag aaagtacaac gactagttca
      901 aaagctaaaa cttcaagtaa aaagttattc aagaaaatct agaaaatact catcctacaa
      961 aggacaggta ggaaaaatat cggacaacaa aataaaaaga aatatttatt accgaaaaaa
     1021 aggggaaatc gagtcaagta ccaacaggct catctattcc aaaaagatat ttactcgatg
     1081 gaaaaactcc tagaattagt gctacaaata ttgacaatgg tatcttaggt tactacgaag
     1141 atatagatga taaaaattat agagtttttg aaaattttat atctgtttca ttt
//
LOCUS       DAVHSO010000137         1166 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.138, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000137 DAVHSO010000000
VERSION     DAVHSO010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1166)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.138"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..1073
                     /locus_tag="VVR18_002261"
                     /pseudo
     CDS             1..1073
                     /locus_tag="VVR18_002261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
BASE COUNT          376 a          241 c          202 g          347 t
ORIGIN      
        1 gatggttgct gaaacttcta tcgtcaagaa gaatcatcaa atccctcgta tcatcaacca
       61 aaagattgct caaaagttaa ttgaaaagat ttctatgacc gatattgccc atcagctttc
      121 catctcaact tcaactgtca ttcgaaagct caatgacttc cactttgagt gtaattttag
      181 aaatctgcct aagattatgt cttgggacgt tgaaacagtc cggggagtga ctgtttcaat
      241 cgggagatgg agatgagctt tattgcgcaa gattttgaaa agctcgatat catcactgtt
      301 cttgaaggta gaacacaagc tgtcatccga gatcactttc ttaaatatga tagagccgtc
      361 cgatgtcgcg tcaaaatcat tactatggat atgtttagcc cttactatga cttggctaaa
      421 cagcttcgct ttcaaatttc taggctcagg ctgaaacagt ctcctagact gtttcactcc
      481 cgaatgctaa aatcgttctt gatcgctttc acattgtaca acatcttagc cgtgctatga
      541 gtcgtgtgcg tgtccaaatc atgaatcagt ttcatcgaaa atcccatgaa cacaaggcta
      601 tcaagcacta ctggaagctc atacaacagg atagccgtaa actgagtgat aagcgatttt
      661 atcgtcctac ttttcgtatg cacttaacca ataaagagat tttaaacaag cttttgagtt
      721 attcggaaga cttgaaacac cactatcagc tctatcagct cttgcttttt cacttccaga
      781 ataaggaacc agagaaattt ttcgaactta tcgaggacaa tcttaagcag gttcatccta
      841 tttttcagac tgtctttaaa accttcctca aagataaaga aaagattatc aacgcccttc
      901 aactacacta ttctaatgcc aaactggaag cgaccaataa tctcatcaaa cttatcaagc
      961 gcaatgcctt tggttttcga aactttgaaa acttcaaaaa acggattttt atcgctttga
     1021 acatcaaaaa agaaaggacg aaatttgggc tctataatat ttgtagtggg taaatcccct
     1081 atggatatta tggagcttat ttttgtgtag aaaaaaagtc ccatatgacc tataatgaaa
     1141 agcgacaaaa caactcatta gaaaga
//
LOCUS       DAVHSO010000138         1074 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.139, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000138 DAVHSO010000000
VERSION     DAVHSO010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.139"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(1..94)
                     /locus_tag="VVR18_002262"
                     /pseudo
     CDS             complement(1..94)
                     /locus_tag="VVR18_002262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558115.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            complement(552..950)
                     /locus_tag="VVR18_002263"
     CDS             complement(552..950)
                     /locus_tag="VVR18_002263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033686.1"
                     /translation="MENKESHKSQEIGNLIRVYNRSKREEAESEPLNLYVEDEKGNLL
                     AGLIAETFGNWLEIEYLFVKEELRGQGIGSKLLQQAESEAKNRNCCFAFVNTYQFQAP
                     DFYQKHGYKEVFSLQDYLYIRQRYYYQKNL"
BASE COUNT          320 a          208 c          160 g          386 t
ORIGIN      
        1 agtgtggata gtttgaggag cttttccaag cagagaggca atttctctat ttgatttccc
       61 tttgttcgcc ttttgtagta taatggtttt gcatctctgt gcctttcttg tgtttgtggt
      121 tgaacaacaa gtataacaca gaggtgtttt cttatgccta caagagcttt cattatttcc
      181 attttctttc ggatttcact ctattctgaa aaacttgtgt atatttactg aagctagcaa
      241 gtcttacctg taaatttaat gaaagcaaca caaaatccga gaggggaatc tcggattaat
      301 gtcaatttaa aaagatagag agtttttagt ttaaataaat tgttttaaaa tatcaacaac
      361 atcacttctt ttcttaacct gataagcctt gattcctaat tttggagcta cgattatatt
      421 gtcctcaata tcgtctagaa agacacaatt tctaggttat aactggtatt tatcgatagt
      481 tactcatata catcagtcca cctccatact tatgtgcgag cctctctttg tattatacct
      541 ccatactcac cttacagatt cttttggtaa taatatcttt gcctaatgta gagatagtct
      601 tgcaaagaaa aaacttcctt gtagccatgt ttctgataaa agtccggtgc ctggaactga
      661 taagtattga caaaggcaaa acaacaattt cgattcttag cttcactttc tgcctgttgc
      721 aatagttttg aaccgattcc ttgccctcgc agttcctctt ttacaaacaa atactcgatt
      781 tctagccaat ttccaaaagt ctctgctatc aaacccgcaa ggagattgcc cttttcatct
      841 tcgacataaa gattaagtgg ctcactttca gcctcttccc tttttgaacg gttataaaca
      901 cgaatcagat tccctatttc ttgcgattta tgtgattcct tattttccaa tctaaagtat
      961 aatgaaatga aataaaacat gcgcaaatcg attaaggaat ttaatctaat ttctaataat
     1021 gtcttagaaa tcaaagttta ctattttaac ttcaatgcac tatacatcta atac
//
LOCUS       DAVHSO010000139          963 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.140, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000139 DAVHSO010000000
VERSION     DAVHSO010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 963)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.140"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..185)
                     /locus_tag="VVR18_002264"
     CDS             complement(<1..185)
                     /locus_tag="VVR18_002264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000989850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033687.1"
                     /translation="MMVVLISVIVAFLYHKITEYVNNRKIDIVIFLSLLISHFIWNYY
                     FLPIEILIAISGANLLL"
     gene            complement(193..564)
                     /locus_tag="VVR18_002265"
     CDS             complement(193..564)
                     /locus_tag="VVR18_002265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPH_0218 family bacteriocin-like peptide"
                     /protein_id="HEU6033688.1"
                     /translation="MELVLPNNYVVIDEEEMMYLDGGAIYIPRWAITGAITGAAYAAL
                     AAAGGGGLQLVLASYGLRSALVAGIVKGLGVLGIHIGNAFANTVIRSIASAGIGAGAD
                     WIFTNIIDGWDGRRDNQLRIG"
BASE COUNT          337 a          207 c          113 g          306 t
ORIGIN      
        1 cttaataata aatttgctcc actgattgct atcaatattt caattggtaa aaaatagtaa
       61 ttccaaataa aatgagaaat cagcaatgat agaaaaataa caatatcaat tttcctgttg
      121 ttgacatact ctgtaatttt atgatacagg aatgcaacaa taactgaaat taaaacaacc
      181 atcataatac tattatccta ttctcaattg attatcacgt cgcccatccc agccatcaat
      241 aatattggta aaaatccaat cagctccagc accaattcca gcagatgcaa tacttctaat
      301 aacagtattt gcaaaagcat ttccaatatg aattcctaat actcctaaac ctttaacaat
      361 cccagctacc agtgcggagc gtaatccata agatgcaaga actagttgaa ggcctccacc
      421 tcctgctgct gctaatgctg catatgctgc accagtaatg gctcctgtaa ttgcccacct
      481 gggtatatat atagcccccc catcaaggta catcatctct tcttcatcaa tcacaacata
      541 attatttggt aatacaagtt ccatttattt tctccttttt tattaagcat gcttaggatg
      601 gtttcctaac aagtgatcgc aggctttgtt tagttaccta aattagactt ccttccttta
      661 tcttatttta aatatttaaa accagttact gcttgaagct taacagttta cttaattcaa
      721 ataacagcta atcactgatt ccctgatttt atcaaatata ctaataacaa caattgtgat
      781 acgatcatca ttataagaac aacatttaac gaatcaaagt ttttccgaga taataataaa
      841 gcaacagcaa gcagtattat tactaaagat tgaataacta ctattactct taacatttta
      901 tcctctacta acaactcaag ctcccttaca ttatatcgac cagccccatg gaaagattat
      961 agc
//
LOCUS       DAVHSO010000140          929 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.142, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000140 DAVHSO010000000
VERSION     DAVHSO010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 929)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.142"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..929
                     /locus_tag="VVR18_002266"
                     /pseudo
     CDS             1..929
                     /locus_tag="VVR18_002266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677188.1"
                     /note="frameshifted; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
BASE COUNT          289 a          204 c          150 g          286 t
ORIGIN      
        1 ttagaaaacg ccgtttcaag tgctatcact gttcaaaaat gatggttgct gagactcccc
       61 tggtaaagaa aaatcaccaa atccctcgta tcatcaacca aaaaattgct caaaagttaa
      121 ttgaaaaaat ttctatgact gatattgccc atcagctttc catttcaact tcaactgtca
      181 ttcgcaagct caatgacttt cactttgagc atgatttttc tcggcttcca aagattatgt
      241 cttgggatga gtatgccttc actaagggaa agatgagttt cattgcgcaa gattttgata
      301 atcttaatat tatcactgtt cttgaaggca gaacacaagc tgtcatccga aatcactttc
      361 ttcgctacga tagagccgtt cgttgtcaag tgaaaatcat tacgatggat atgtttagtc
      421 cttactatga cttggctaaa cagcttcgct ttcaaatttc taggctcagg ctgaaacagt
      481 ctcccagact gtttcactcc cgaatgctaa aatcgttctt gatcgctttc acattgtaca
      541 acatcttagc cgtgctatga gtcgtgtgcg tgttcaaatt atgaatcagt ttgaacgaaa
      601 atctcatgaa tacaaggcta tcaagcgtta ctggaaactc atccaacagg atagtcgtaa
      661 actcagcgat aaacgttttt atcgccctac ttttcgcatg cacttaacaa ataaagaaat
      721 tcttgacaag attttaagct attcagaaga cttgaaacac cactatcaga tctatcaact
      781 cttacttttt cactttcaga acaaagaccc tgagaaattt ttcggactca ttgaggacaa
      841 tctgaagcag gttcatccta tttttcagac tgtctttaaa acctttctaa agaacaaaga
      901 gaaaatcgtc aacgcccttc aactaccct
//
LOCUS       DAVHSO010000141          904 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.143, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000141 DAVHSO010000000
VERSION     DAVHSO010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 904)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 904)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.143"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..423
                     /locus_tag="VVR18_002267"
                     /pseudo
     CDS             1..423
                     /locus_tag="VVR18_002267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
     gene            complement(456..665)
                     /locus_tag="VVR18_002268"
                     /pseudo
     CDS             complement(456..665)
                     /locus_tag="VVR18_002268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(831..904)
                     /locus_tag="VVR18_002269"
     tRNA            complement(831..904)
                     /locus_tag="VVR18_002269"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(868..870),aa:Asn,seq:gtt)
BASE COUNT          293 a          181 c          158 g          272 t
ORIGIN      
        1 ctatcgtcaa gaagaatcac caaatccctc gtattatcaa ccaaaagatt gctcaaaagt
       61 taattgaaaa gatttctatg accgacattg atcatcagtt gtctatttca acttcaactg
      121 tcattcgcaa gatcaatgat tttcactttg agcatgattt ttcgcgtctt cctgagatta
      181 tgtcctagga cgttgaaaca gtccggggag tgactgtttc aatcgggaga tggagatgag
      241 ctttattgct caggactttg ataaactcaa tatcataact gttcttgaga gcagaacaca
      301 agccatcatc cgaaatccca tggatacaag gctatcaagc gctactggaa actcattcaa
      361 caggatagtc gtaaactgag tgataaacat ttttatcgtc ctacttttcg tatgcacttg
      421 acaaagaacc gaaaaatgtc tcgcctctaa tatagtcaat tgaaacaaga acaagacaaa
      481 agagcctcgt aaaaggtatt gcaacttggt aatacctttt tgaggtgctt tttgatatga
      541 gcccatgttt tcttaatagg attgtactca ggtgagtagg gaggaagagg taaaagttca
      601 tgcccaaact cctcgcataa aagttctagc ttacccattc tatggaatct tgcattgtcc
      661 ataatatagt agattgaaac tagaatagta cacctctact tctaaaacat tgttagaatt
      721 cgattttact gtcctgatcg atttgtccta ttcttatttc attttactat aacacgaaat
      781 agattattat tacataacaa aaaagaggtc taaacctctt aactaaatta ctccgccagt
      841 aggactcgaa cctacgacat catgattaac agtcatgcgc tactaccaac tgagctatgg
      901 cgga
//
LOCUS       DAVHSO010000142          873 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.144, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000142 DAVHSO010000000
VERSION     DAVHSO010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 873)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 873)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.144"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            150..>873
                     /locus_tag="VVR18_002270"
     CDS             150..>873
                     /locus_tag="VVR18_002270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU6033689.1"
                     /translation="MRYDFGKVYKEIRESKGLTQEEVCGGVLSRTSLSKIESGKTTPK
                     YENMEFLLRQINMSFEEFEYICQLYQPSQRTEIMQTYLNMRSIIGTSDLVNLFQKCQD
                     YLKTHHDLPIEEIRDMLEVVIYLRQHGAGELSKHAKQVVKKLWKKIEKQDTWYESDLK
                     ILNTILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRMTILLNLSTLYLYNQDKNMC
                     KQICYTLLEDAKNKKSYDRLAIC"
BASE COUNT          308 a          168 c          136 g          261 t
ORIGIN      
        1 atacctctta ttaagctcat tttaaaatta cgttaacttt tttcacaaat ttatttcgac
       61 tttctttttt actttttaca ttgctatgat acaatatttt taacaagatt ttattgtttg
      121 ttaacttttt tcacagaaag gagaaaatca tgcgttatga tttcggaaag gtctataaag
      181 aaatacgtga gtcaaagggg ctgacccaag aagaggtctg tgggggtgtt ctctcaagaa
      241 ccagcttatc aaaaatcgaa agtggcaaga caaccccaaa atatgaaaat atggaatttc
      301 ttctccgtca aatcaatatg agttttgaag agtttgaata tatctgtcaa ctttatcaac
      361 caagtcaacg cacagagatt atgcaaacct atctcaatat gcgttccatt atcgggacca
      421 gcgatcttgt caatttattt caaaaatgcc aagactacct caagacccac cacgatctcc
      481 ctatagaaga aatcagagat atgcttgaag ttgttattta tctccgtcaa cacggggcag
      541 gggaactatc aaaacacgca aaacaggttg tcaaaaaact ttggaaaaaa attgaaaaac
      601 aagatacatg gtatgagagt gatctaaaaa tcctcaatac cattcttttc agttttccca
      661 ttgaatacct ccatctcatc actggaaaaa tattgcaacg cctagaagtc tataaaaact
      721 atcaacattt atatgacttg cgaatgacaa ttctattaaa cctttccaca ctctatctat
      781 acaatcaaga taaaaacatg tgtaagcaaa tctgctacac tttactggag gacgccaaga
      841 ataagaaaag ctacgatagg ctggctatct gct
//
LOCUS       DAVHSO010000143          872 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.145, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000143 DAVHSO010000000
VERSION     DAVHSO010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 872)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.145"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            138..872
                     /locus_tag="VVR18_002271"
                     /pseudo
     CDS             138..872
                     /locus_tag="VVR18_002271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
BASE COUNT          303 a          162 c          167 g          240 t
ORIGIN      
        1 ccctgcgaaa caaaatatgg tatagtatag tatattgaaa ctagaatagt acgcctctac
       61 ttctaaaaca ttgttagaaa tcgatttgac tgtcctgatc gatttatcct gttcttattt
      121 cattttacta tagttctatg aatgatgaag caagtaaaca actaactgat acacgattta
      181 aatgtcttgt tggtgttcag cacacgactt ttgaagagat gttagctgtg ttaaaaacag
      241 cttatcaact taaacacgca aaaggtggac gaaaacctaa attaagccta gaagaccttc
      301 ttatggccac tcttcactat gtacgagaat accgcactta tgaagaaatt gcggctgatt
      361 ttggtatcca cgaaagcaac ttactccgtc ggagccaatg ggttgaagta actcttgttc
      421 aaaggtggtg ttacgatttc aagaactcct ctcagttctg aagacacggt aatgattgat
      481 gcgacggaag taaaaatcaa tcgccctaaa aaaaacaatt agcgaatgat tctggtaaaa
      541 agaaatttca cgctatgaag gctcaagcga ttgtcacaag tcaagggaga attgtttctt
      601 tggatatcac tgtgaactat tgtcatgata tgaagttgtt caaaatgagt cgcagaaata
      661 tcggacaaac tggtaaaatc ttggctgaca gtggttatca aggacccatg aagatatatc
      721 ctcaagcaca aactccacgt aaatccagca aactcaagcc gctaacagtt gaagataaag
      781 cctataacca tgcgctatct aaggagagaa gcaaggttga gaacatcttt gccaaagtaa
      841 aaacgtttaa aatgatttca acaacctatc ga
//
LOCUS       DAVHSO010000144          851 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.146, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000144 DAVHSO010000000
VERSION     DAVHSO010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 851)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 851)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.146"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..>851
                     /gene="phtB"
                     /locus_tag="VVR18_002272"
     CDS             <1..>851
                     /gene="phtB"
                     /locus_tag="VVR18_002272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtB"
                     /protein_id="HEU6033690.1"
                     /translation="SRTARGVAVPHGNHYHFIPYEQMSELEKRIARIIPLRYRSNHWV
                     PDSRPEEPSPQPTPEPSPSPQPAPNPQPAPSNPIDEKLVKEAVRKVGDGYVFEENGVS
                     RYIPAKDLSAETAAGIDSKLAKQESLSHKLGTKKTDLPSSDREFYNKAYDLLARIHQD
                     LLDNKGRQVDFEALDNLLERLKDVSSDKVKLVEDILAFLAPIRHPERLGKPNAQITYT
                     DDEIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAA
                     QAYAKEK"
BASE COUNT          277 a          183 c          180 g          211 t
ORIGIN      
        1 caagtcgaac cgccagaggt gtagctgtcc ctcatggtaa ccattaccac tttatccctt
       61 atgaacaaat gtctgaattg gaaaaacgaa ttgctcgtat tattcccctt cgttatcgtt
      121 caaaccattg ggtaccagat tcaagaccag aagaaccaag tccacaaccg actccggaac
      181 ctagtccaag tccgcaacct gcaccaaatc ctcaaccagc tccaagcaat ccaattgatg
      241 agaaattggt caaagaagct gttcgaaaag taggcgatgg ttatgtcttt gaggagaatg
      301 gagtttctcg ttatatccca gccaaggatc tttcagcaga aacagcagca ggcattgata
      361 gcaaactggc caagcaggaa agtttatctc ataagctagg aactaagaaa actgacctcc
      421 catctagtga tcgagaattt tacaataagg cttatgactt actagcaaga attcaccaag
      481 atttacttga taataaaggt cgacaagttg attttgaggc tttggataac ctgttggaac
      541 gactcaagga tgtctcaagt gataaagtca agttagtgga agatattctt gccttcttag
      601 ctccgattcg tcatccagaa cgtttaggaa aaccaaatgc gcaaattacc tacactgatg
      661 atgagattca agtagccaag ttggcaggca agtacacaac agaagacggt tatatctttg
      721 atcctcgtga tataaccagt gatgaggggg atgcctatgt aactccacat atgacccata
      781 gccactggat taaaaaagat agtttgtctg aagctgagag agcggcagcc caggcttatg
      841 ctaaagagaa a
//
LOCUS       DAVHSO010000145          842 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.147, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000145 DAVHSO010000000
VERSION     DAVHSO010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 842)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 842)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.147"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..>842
                     /locus_tag="VVR18_002273"
     CDS             <1..>842
                     /locus_tag="VVR18_002273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU6033691.1"
                     /translation="SLEYGLPSRTILLNWLAQYRKNGYTIVEKTKGRVPESGECHPKK
                     VKRTPIEGGKRERRKTEIVQELMTEFSLDLLLKSIKLARWTYYYHLKQLDKTDKDQEL
                     KAEIQSIFIEHKGNYAYRRVHLELRNRAYLVNHKRVQGLMKVLNLQAKMRQKRKYSSH
                     KGDVSKKAENLIQGQFEGSKTMEKCYTDVTEFAIPASTQKLYLSPVLDGFNSEIIAFN
                     LSCSPNLEQVQTMLEQAFKEKHYENTILHSDQGWQYQHDSYHRFLESKGIQASMSRKG
                     NSQD"
BASE COUNT          315 a          155 c          163 g          209 t
ORIGIN      
        1 tctcttgaat acggcctccc aagtcgtacg atacttctta actggctagc acaatacagg
       61 aaaaacgggt atactattgt tgagaaaaca aaagggagag tacctgagag cggagaatgc
      121 catcctaaaa aagttaagag aactccgatt gaaggaggaa aaagagaaag aagaaagaca
      181 gaaattgttc aagaattaat gactgagttt tcgttagatc ttcttctaaa atccattaaa
      241 ctagctcgtt ggacctacta ctatcacttg aaacagctag acaaaacaga taaggaccaa
      301 gagcttaaag ctgaaattca atccattttt atcgaacaca aaggaaatta tgcttatcgc
      361 cgggttcatt tagaactaag aaatcgtgct tatctggtaa atcataaaag agttcaaggc
      421 ttgatgaaag tactcaattt acaagctaaa atgcgacaga aacgaaaata ttcttctcat
      481 aaaggagacg ttagcaagaa ggcagagaat ctcattcaag gccaatttga aggctctaaa
      541 acaatggaaa agtgctacac agatgtgaca gaatttgcca ttccagcaag tactcaaaag
      601 ctttacttat caccagtttt agatggcttt aacagcgaaa ttattgcttt taatctttct
      661 tgttcgccta atttagaaca agtacaaaca atgttggaac aggcattcaa agagaagcac
      721 tacgagaata cgattctcca tagtgaccaa ggctggcaat atcaacacga ttcttatcat
      781 cggttcctag agagtaaggg aattcaagca tctatgtcac gcaagggaaa cagccaagac
      841 aa
//
LOCUS       DAVHSO010000146          830 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.148, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000146 DAVHSO010000000
VERSION     DAVHSO010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 830)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 830)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.148"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            21..830
                     /locus_tag="VVR18_002274"
                     /pseudo
     CDS             21..830
                     /locus_tag="VVR18_002274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558050.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element IS1515 family transposase"
BASE COUNT          266 a          174 c          162 g          228 t
ORIGIN      
        1 aaaagtgtta tactattttt atggaaacag tatacgacaa agcacaaaaa cttaactcaa
       61 aaaacttcaa actattgatt ggtgtcaaaa aggaaacctt tcaactcatg ctagaacacc
      121 tgaattcagc ctatcagatt cagcaccgaa aaggtggacg tccacgtagt ctgcccatgg
      181 aagaccagct cattatgacc ctccgttact tgcgatatta tcccactcag cgtctgctgg
      241 cctttgattt tggcgtcggt gtagctacgg taaatgccat catcacttgg gtggaggata
      301 cacttcgtgc gtcaggtagc tttgatttgg accatttaga agccccgagt gctgctgtgg
      361 ctattgacgt gaccgaaagt ccgattcagc gtccaaaaaa aaccaaagca aaaattattc
      421 tggtaaaaag aaacgacaca ccttaaaaac tcaaattatg ctggatttga cgacacataa
      481 agtctgtcaa atggcctttt ctgacggaca tacgcatgat tttactctct tcaaagaaag
      541 tattggacaa agtttgcctg aaacgacgct tgcctttgtt gacctaggtt atttaggcat
      601 cttgaaattt catgagaata ctttcattcc tgctaaaaat tccaaaaatc gccgcctgag
      661 tgaggatgat aagcagttaa ataaagagat gtcagcgata cgaattgaaa ttgaacattt
      721 taacgctaaa ttcaagacct tccaaatcat gtcagtccct tatcgtaacc gcagaaaacg
      781 tttcgagtta cgggcggaat taatttgtgc catcatcaat tatgaagtga
//
LOCUS       DAVHSO010000147          806 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.149, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000147 DAVHSO010000000
VERSION     DAVHSO010000147.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 806)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.149"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(46..444)
                     /locus_tag="VVR18_002275"
     CDS             complement(46..444)
                     /locus_tag="VVR18_002275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033692.1"
                     /translation="MKAPIPKAPLAHSLGSASIIAHTIHQKFNLKVPNYRQEEDWAKM
                     GLPITRKEIANWHIKASQYYLEPLYNLLRERLLTQSLLHADETSYRVLESDSQLTYYW
                     TFLSGKAEKQGITLYHHVLIDLFISYFNPL"
     gene            435..743
                     /locus_tag="VVR18_002276"
                     /pseudo
     CDS             435..743
                     /locus_tag="VVR18_002276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT          267 a          145 c          161 g          233 t
ORIGIN      
        1 cgtttggaag acattctaga agataggata aatatttctc actatttata atggattgaa
       61 ataagatatg aacaaatcga ttaggacatg atggtaaagc gtaatccctt gtttctcagc
      121 tttcccagac aaaaaagtcc aatagtaagt cagctgacta tcactctcta gcaccctata
      181 agaagtttca tccgcatgaa gtaaggactg cgtcaatagt ctctctcgca agaggttata
      241 aaggggctcc aaatagtatt gactcgcctt gatatgccaa ttagcaattt ccttacgtgt
      301 gattggtaaa cccatcttag cccaatcttc ttcttggcga taattgggta ccttcagatt
      361 aaacttctga tggatggtgt gagcgataat agaagctgag ccaaggctat gcgccaaagg
      421 ggctttagga ataggagctt tcacaagctt atccagatga ttatctttta ctcgttatgg
      481 acaatgctat atggcataaa tcaagtacct taaagattcc gactaatatt ggttttacct
      541 ttattcctcc atacacacca gagatgaacc ccattgaaca agtgtggaaa gagattcgta
      601 aacgtggatt taagaataaa gcctttcaaa ctttggaaga tgtcatgaat caactccaag
      661 atgttataca aggactggag aaggaggtga taaagtccat cgttaatcgg agatggacta
      721 gaatgctttt tgaaaacaga tgagcataaa aagaaagtcc tcatttcaat agaaatcacg
      781 actttctgat ggatttatag taaaat
//
LOCUS       DAVHSO010000148          766 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.150, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000148 DAVHSO010000000
VERSION     DAVHSO010000148.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 766)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 766)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.150"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            289..609
                     /locus_tag="VVR18_002277"
     CDS             289..609
                     /locus_tag="VVR18_002277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU6033693.1"
                     /translation="MQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYTL
                     LEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVETYYQ
                     PKER"
BASE COUNT          260 a          152 c          116 g          238 t
ORIGIN      
        1 ttattttcta cctacatagt acctcttatt aagctcattt caaaattacg ttaacttttt
       61 tcacgaaaag gagaaaatta tgcgttatga ttatggatag cgctttcaaa tttttaaact
      121 cctatcccat ccttttatct atattatgag cgaaaatata ataactgtca agtaactaaa
      181 gtgaatttta taaaaaaatt acaagccaaa tttgtaaagt ttacactaag ccgctagggc
      241 aatcgtctat cagaatgtcc gtttatttgt caataatccg agaaaatctt gcaacgctta
      301 gaagtctata aaaactatca acatttatat gacttgcgaa tagcaatcct gctcaacctt
      361 tccacactct atctatacaa tcaagataaa aacatgtgta agcaaatctg ctacacttta
      421 ctagaggacg ccaagaataa gaaaagctac gataggctgg ctatctgcta tgtccgtatt
      481 gggatttgta cagacgattc taaacttatc caaaaagggt tctcccttct ggagctaacc
      541 gaggaaactt ctatgctgtc tcatctcaaa aaagaagtag aaacctatta tcaaccgaag
      601 gaaagataaa aaagccgagg gatttcctcg actctttaca tattatttgt tcgttagttc
      661 ttaataccag ccattgttaa accagaagtt tttagctctg ccaagccaca tagtgtgttt
      721 actactatgt gtccatgtca ccatgaatcg ccgaacgatt taacga
//
LOCUS       DAVHSO010000149          711 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.151, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000149 DAVHSO010000000
VERSION     DAVHSO010000149.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 711)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.151"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..>711)
                     /locus_tag="VVR18_002278"
     CDS             complement(<1..>711)
                     /locus_tag="VVR18_002278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HEU6033694.1"
                     /translation="EYAFTKGKMSFIAQDFNNLNIITVLEGRTQAIIRNHFLKYDRAV
                     RCRVKIITMDMFSPYYDLARQLFPCAKIVLDRFHIVQHLSRAMSRVRVQIMNQLDRKS
                     HEYKAIKRYWKLIQQDSRKLSDKHFYRPTFRMHLTNKEILNKLLSYSQDLKHHYQLYQ
                     LLLFHFQNKEPEKFFGLIEDNLKQVHPLFQTVFKTFLKDKEKIVNALQLHYSNAKLEA
                     TNNLIKLIKRNAFGFRNFE"
BASE COUNT          216 a          120 c          149 g          226 t
ORIGIN      
        1 ttcaaagttc cgaaaaccaa aggcattgcg cttgataagt ttgatgagat tattggtcgc
       61 ttccaatttg gcgttagaat agtgtagttg aagggcgttg acgattttct ctttgtcctt
      121 tagaaaggtt ttaaagacag tctgaaaaag aggatgaacc tgctttagat tgtcctcaat
      181 gagtccgaaa aatttctccg gttccttatt ctgaaagtga aacagcaaga gttgatagag
      241 ctgatagtga tgtttcaagt cttgtgaata gctcaaaagc ttgtttaaaa tctctttatt
      301 ggttaaatgc atacgaaaag tagggcgata aaaatgttta tcgctgagtt tacgactatc
      361 ctgttgtatg agcttccagt agcgcttgat agccttgtat tcatgagact ttcgatccaa
      421 ttgattcatg atttgaacac gcacacgact catagcacgg ctaagatgtt gtacaatgtg
      481 aaagcgatcc aacacgattt tagcacatgg gaaaagttgt ctagctaagt catagtaagg
      541 actaaacata tccatagtaa taattttgac gcgacatcgg acggctctat catatttaag
      601 aaagtgattt cgaatgatag cttgtgttct tccctcaaga acagtgatga tattgagatt
      661 gttaaaatct tgcgcaatga agctcatctt tccctttgta aaagcatact c
//
LOCUS       DAVHSO010000150          652 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.153, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000150 DAVHSO010000000
VERSION     DAVHSO010000150.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 652)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 652)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.153"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..362
                     /locus_tag="VVR18_002279"
     CDS             <1..362
                     /locus_tag="VVR18_002279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033695.1"
                     /translation="LVESGHMKQALEEIFEYIRSANKFYDDMKPWALRESDIEKCKEV
                     LATCVIIILNLGQMLNPFIPFSGKKIEDMFKTKLNTWNYISNLPNKLSDVSMLFDRID
                     LKKIDEEVLELQQTSSR"
     gene            463..>652
                     /locus_tag="VVR18_002280"
     CDS             463..>652
                     /locus_tag="VVR18_002280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase"
                     /protein_id="HEU6033696.1"
                     /translation="MNNLTLLKEYNFRDLGNHLTQTGQKIKPKTLFRSSKLFGISKID
                     VDLLQSYGITKVIDFRSAN"
BASE COUNT          253 a           84 c          110 g          205 t
ORIGIN      
        1 atttagttga gagcgggcat atgaaacagg cattagaaga aatttttgaa tatattagat
       61 cggctaataa attctatgat gatatgaaac cgtgggcatt gcgagagtcc gatattgaaa
      121 aatgtaaaga agtcttagct acttgtgtaa tcattatact taatttagga caaatgttaa
      181 atccattcat tcctttttct ggtaaaaaga ttgaggatat gtttaaaaca aagctaaata
      241 cttggaatta tatttcaaac cttcctaaca agctatcaga tgtatcaatg ttgtttgata
      301 ggattgattt gaaaaaaatt gacgaggaag ttttagaatt gcaacaaaca tccagtagat
      361 aattcaaaaa tactcgaaag tagccttttt taatttaaat taacaaccgg agatgttgaa
      421 taaaataaag atggtttttt gagcatatta tggagaaaag cattgaataa tctaacttta
      481 ctaaaagaat ataattttag agatcttgga aaccacctca ctcaaacagg acaaaaaata
      541 aaacctaaaa cattattccg ttcaagtaaa ctatttggaa tctctaaaat tgatgtcgat
      601 ttgttacaga gctatggaat aacaaaagtc attgactttc gatcagcgaa tg
//
LOCUS       DAVHSO010000151          631 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.154, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000151 DAVHSO010000000
VERSION     DAVHSO010000151.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 631)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 631)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.154"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..>631
                     /locus_tag="VVR18_002281"
     CDS             <1..>631
                     /locus_tag="VVR18_002281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033697.1"
                     /translation="SIKRNLYIPYLVALEFHFNKSNKKKTKKRNADSYFKQVESALNQ
                     LKSSVQNTDLIKMDIENGKLKHLIGNLEFFTDDFLTKVNLFVRDEITDKEDEVYKELL
                     NIISDSIGDVYEQEWIYEIEKEGEKRFAEAIPPGFNDENKDGIRKYNGISYHQKYGDL
                     IIWKDILKKATEQPRGDKVIFITNDGESNKKSDLIYKTSNMKVGPSIFLM"
BASE COUNT          262 a           56 c          110 g          203 t
ORIGIN      
        1 tcaataaaga gaaatcttta tataccttat ttagtcgctc ttgaatttca ttttaataaa
       61 agtaataaaa agaaaactaa aaagagaaat gcagactcat actttaaaca agttgaatct
      121 gcattgaatc aattaaaatc aagtgtacag aatactgatt taattaaaat ggatattgag
      181 aatggtaaac taaaacattt gattgggaat ttggagtttt ttactgatga ttttttgact
      241 aaggtgaatt tatttgtaag agatgaaatt actgataaag aagatgaagt ttataaagag
      301 ttacttaata ttatttctga ttctattgga gatgtgtatg agcaggaatg gatatatgaa
      361 atagaaaaag aaggagaaaa acgttttgca gaagctattc caccgggatt taatgacgaa
      421 aataaagatg gaataagaaa atataatggc atatcttatc atcaaaaata tggtgattta
      481 attatttgga aggatatatt aaaaaaagca acggaacaac ctcgtggtga taaagttatc
      541 tttattacta atgacggaga atcaaataaa aaaagtgatt taatttataa aacttcaaat
      601 atgaaagttg gtccaagtat tttcttgatg a
//
LOCUS       DAVHSO010000152          624 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.155, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000152 DAVHSO010000000
VERSION     DAVHSO010000152.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 624)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.155"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..220
                     /locus_tag="VVR18_002282"
     CDS             <1..220
                     /locus_tag="VVR18_002282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU6033698.1"
                     /translation="EVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERV
                     LSNERFRGRQRVLRDLRIVFKEFTIRTH"
     gene            314..385
                     /locus_tag="VVR18_002283"
     tRNA            314..385
                     /locus_tag="VVR18_002283"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:347..349,aa:Glu,seq:ttc)
BASE COUNT          241 a           89 c          144 g          150 t
ORIGIN      
        1 agaagtgggt gagatcagtc atcgtataag tgaggggggt ctctggctag atgattatta
       61 tctctttcat gaaacactaa gagattatag aaacaaacaa agtaaagaga aacaagaaga
      121 actagaacgc gtcttaagca atgaacgatt tcgagggcgt caaagagtat taagagactt
      181 acgcattgtg tttaaggagt ttactatccg tacccattag taagtcatgc aaaaaaaatg
      241 aaaaaaatta gaaaaagtag ttgacaaagt ttgaaaaggc tgtataatag taagagttga
      301 aaataacaac tcaggtccgt tggtcaaggg gttaagacac cgccttttca cggcggtaac
      361 acgggttcga atcccgtacg gactatggta tgttgcggtt ggaacacttg atgaaaaaaa
      421 gtttaaaaaa agcttaaaaa tcttcaaaaa agtgttgaca agtgaaagtg gctgtgatat
      481 actaatatag ttgtcgcttg agagaagcaa gtgacaaaga cctttgaaaa ctgaacaaga
      541 cgaaccaatg tgcagggcgc tacaacataa gttgtagtac tgaacaatga aaaaacaata
      601 aatctgtcag tgacagaaat gagt
//
LOCUS       DAVHSO010000153          621 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.156, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000153 DAVHSO010000000
VERSION     DAVHSO010000153.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 621)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 621)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.156"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..621
                     /locus_tag="VVR18_002284"
                     /pseudo
     CDS             1..621
                     /locus_tag="VVR18_002284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436408.1"
                     /note="frameshifted; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT          185 a          132 c          121 g          183 t
ORIGIN      
        1 gtcaagaaga atcaccaaat ccctcgtatc atcaaccaaa agattgctca aaagttaatt
       61 gaaaagaatt ctatgaccga tattgcccat cagctggcca tttcaacttc aactgtcatt
      121 cgaaagctca atgacttcca ctttgagtgt aattttagaa atctgcctga gattatgtcc
      181 tgggacgttg aaacagtccg gggagtgact gtttcaatcg ggagatggag atgagcttta
      241 ttgcgcaaga ttttgaaaag ctcgatatca tcactgttct tgagggtaga atacaagctg
      301 tcatccgaga tcattttctt aagtatgata gagccgtccg atgtcgcgtc aaaatcatta
      361 ctatggatat gtttagccct tactatgact tggctaaaca gcttcgcttt caaatttcta
      421 ggctcaggct gaaacagtct cccagactgt ttcactcccg aatgctaaaa tcgttcttga
      481 tcgctttcac attgtacaac atcttagccg tgctatgagt cgtgtgcatg tccaaatcat
      541 gaatcagttt gaacgaaaat ctcatgaata caaggctatc aagcgttact ggaaactcat
      601 ccaacaggat agtcgtaaat t
//
LOCUS       DAVHSO010000154          523 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.157, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000154 DAVHSO010000000
VERSION     DAVHSO010000154.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 523)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.157"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(108..>523)
                     /locus_tag="VVR18_002285"
     CDS             complement(108..>523)
                     /locus_tag="VVR18_002285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033699.1"
                     /translation="TSGTSQDQFQLYRGRGQAENFIKEMKEGFFGDKTDSSTLIKNEV
                     RMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLHVVGKCVRTGRKQLLKLSSLYA
                     YSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMH"
BASE COUNT          139 a          113 c          105 g          166 t
ORIGIN      
        1 cagttttact ttctgctgtt ccagtatcgt ttttcctcgc tagatttcct caaaagggca
       61 gactcctccc ttggtgcgtc acacgatttt ttcatctcga ctgttcttta atgcatcatt
      121 aacgacgctt ttcttctagg tggttcataa ggaacaggaa gattcaggtt gacttttcta
      181 atcctagaat aaagtgctga aaacaattcg gaataggcat agagactaga caatttgagg
      241 agctgcttgc gtcctgttcg aacacatttt cctaccacgt gaagaaaaag atggcggaag
      301 cgtttgattg ttaaagtttg gaagtcacct ccagctagat gtttgagaaa aagatagaga
      361 ttgtaggcga tacagctcat catcatacga acttcgtttt tgattaaggt tgaactatcc
      421 gttttatcgc caaaaaatcc ctccttcatc tccttgatga aattctcggc ttgaccacgt
      481 ccacgataaa gctgaaactg gtcttggctt gttccactcg tca
//
LOCUS       DAVHSO010000155          493 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.159, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000155 DAVHSO010000000
VERSION     DAVHSO010000155.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 493)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.159"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..>493)
                     /locus_tag="VVR18_002286"
     CDS             complement(<1..>493)
                     /locus_tag="VVR18_002286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033700.1"
                     /translation="GSIRQEILNATKDKASKSELTQTAEELASRIASVKVGGRNYYRD
                     SEKIRTSTRFFSFPLHPYLSQENVGETWTLSFDLKINEGGEIRPLLFYHYQTNRFGLK
                     ASADITPSKEWQRFTFTGPVIFPNDDPRYSRGEMALYDHGGNNNYSVRRIKLEKGTLA
                     TDWS"
BASE COUNT          133 a          112 c          102 g          146 t
ORIGIN      
        1 gactccagtc agtagctaaa gtgccttttt caagtttaat cctacgcaca gaatagttat
       61 tatttccacc gtggtcatac aaggccatct ctcccctcga ataacgaggg tcgtcgttcg
      121 gaaagataac tggacctgtg aacgtgaacc gttgccattc tttgcttgga gtgatgtctg
      181 cactagcttt cagaccaaat cgatttgttt ggtaatgata aaaaagaaga ggacggattt
      241 cgccaccttc attgattttt aaatcaaacg ataaagtcca agtctccccg acattttctt
      301 gtgaaagata tggatgcaaa ggaaacgaaa agaaacgtgt acttgttcga atcttctcag
      361 aatctcgata atagtttctg ccaccaactt taacactcgc aatccgacta gctagctcct
      421 cagctgtctg cgtgagttct gacttgctgg ctttatcctt ggttgcgttc aggatttcct
      481 gacggataga gcc
//
LOCUS       DAVHSO010000156          365 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.160, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000156 DAVHSO010000000
VERSION     DAVHSO010000156.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 365)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.160"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            <1..>365
                     /locus_tag="VVR18_002287"
     CDS             <1..>365
                     /locus_tag="VVR18_002287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HEU6033701.1"
                     /translation="DYVIYNIPQLAGVALTPSLYTEMLKNPRVIGVKNSSMPVQDIQT
                     FVSLGGEDHIVFNGPDEQFLGGRLMGARAGIGGTYGAMPELFLKLNQLIADKDLETAR
                     ELQYAINAIIGKLTSAHGN"
BASE COUNT           96 a           76 c           85 g          108 t
ORIGIN      
        1 gactacgtga tttacaacat tcctcaattg gcaggggttg ctttgactcc aagcctttac
       61 acagaaatgt tgaaaaatcc tcgtgttatc ggtgttaaga actcttctat gccagttcaa
      121 gatatccaaa cctttgtcag ccttggtggg gaagaccata tcgtctttaa tggtcctgat
      181 gagcagtttc taggaggacg cctcatgggt gctagggctg gtatcggtgg tacttatggt
      241 gctatgccag aactcttctt gaaactcaat cagttgattg cggataagga cctagaaaca
      301 gcgcgtgaat tgcagtatgc tatcaacgca atcattggta aactcacttc tgctcatgga
      361 aatat
//
LOCUS       DAVHSO010000157          327 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.161, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000157 DAVHSO010000000
VERSION     DAVHSO010000157.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 327)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.161"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..327
                     /locus_tag="VVR18_002288"
                     /pseudo
     CDS             1..327
                     /locus_tag="VVR18_002288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
BASE COUNT          107 a           51 c           72 g           97 t
ORIGIN      
        1 cgagaatatc gaacttatga agaaattgcg gctgtttttg gtatccacga aagcaactta
       61 ctccgtcgga gccaatgggt tgaagtaact cttgttcaaa gtggtgttac gatttcaaga
      121 actcatctta gtgctgagaa tacggtgatt gtggatgcaa cagaggtaaa aataaatcgt
      181 cctaaaaaaa tcaactagcc aattattctg gtaaaataga aatgtcattc tatggaacct
      241 caagcgattg tcacaagtca agggagaatt gtttctttgg atatcgctgt gaactattgt
      301 catgatatga agttgttcaa aatgagt
//
LOCUS       DAVHSO010000158          311 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.162, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000158 DAVHSO010000000
VERSION     DAVHSO010000158.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 311)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.162"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            174..>311
                     /locus_tag="VVR18_002289"
     CDS             174..>311
                     /locus_tag="VVR18_002289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033702.1"
                     /translation="MQDNYTTKGKHLTIDSRRLIERWKKEGKSNREIASLLGKAPQTI
                     HT"
BASE COUNT          117 a           62 c           50 g           82 t
ORIGIN      
        1 ctgttcttgt ttcattttac tatatgttcg taaatgaaag ttctataatg aagttagcca
       61 cccagccctc ctaaaaatta gatggttcaa ctagctgaaa gctcttgtag gcataagaaa
      121 acacctctgt gttatacttg ttgttcaacc acaaacacaa gaaaggcaca gaaatgcaag
      181 acaattatac tacaaaaggt aaacatttga caatcgatag ccgtcgctta atcgaaagat
      241 ggaaaaaaga aggaaaatca aatagagaaa ttgcctctct acttggaaaa gctcctcaaa
      301 ctatccacac t
//
LOCUS       DAVHSO010000159          253 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.denovo.164, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000159 DAVHSO010000000
VERSION     DAVHSO010000159.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 253)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 253)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.denovo.164"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            complement(<1..>253)
                     /locus_tag="VVR18_002290"
     CDS             complement(<1..>253)
                     /locus_tag="VVR18_002290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU6033703.1"
                     /translation="LEGGQLASQPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQL
                     NQLIVDIDSTHFTTYGKQEGVAYNAHYRAHGYHPLYAFEG"
BASE COUNT           77 a           50 c           63 g           63 t
ORIGIN      
        1 cccctcgaaa gcataaagag gatgatagcc atgagcacga tagtgggcgt tataagcaac
       61 accttcttgc ttgccataag ttgtgaaatg ggtagaatcg atatctacaa tgagttggtt
      121 tagctggtga aactgtaaaa agaattcgac caattcaagg ttgaggcatc gcaaactatg
      181 gactgtttcc tcgtcagttc tggaaagaaa acgggataag gttggctgtg aagcaagctg
      241 ccctccttcc aac
//
LOCUS       DAVHSO010000160        15549 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.guided.053, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000160 DAVHSO010000000
VERSION     DAVHSO010000160.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 15549)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15549)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15549
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.guided.053"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            1..435
                     /locus_tag="VVR18_002291"
                     /pseudo
     CDS             1..435
                     /locus_tag="VVR18_002291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002844950.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
     gene            768..1082
                     /locus_tag="VVR18_002292"
     CDS             768..1082
                     /locus_tag="VVR18_002292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU6033704.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            1098..1484
                     /locus_tag="VVR18_002293"
     CDS             1098..1484
                     /locus_tag="VVR18_002293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU6033705.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            1513..2898
                     /locus_tag="VVR18_002294"
     CDS             1513..2898
                     /locus_tag="VVR18_002294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEU6033706.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            2901..3053
                     /locus_tag="VVR18_002295"
     CDS             2901..3053
                     /locus_tag="VVR18_002295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6033707.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            3076..4281
                     /locus_tag="VVR18_002296"
     CDS             3076..4281
                     /locus_tag="VVR18_002296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HEU6033708.1"
                     /translation="MEGFLLNEQTWLQHLKEKRLAYGLSQNRLAVATGITRQYLSDIE
                     TGKVKPSEDLQQSLWEALERFNPDAPLEMLFDYVRIRFPTTDVQQVVENILQLKLSYF
                     LHEDYGFYSYSEHYALGDIFVLCSHELDKGVLVELKGRGCRQFESYLLAQQRSWYEFF
                     MDVLVAGGVMKRLDLAINDKTGILNIPVLTEKCQQEECISVFRSFKSYRSGELVRKEE
                     KECMGNTLYIGSLQSEVYFCIYEKDYEQYKKNDIPIEDAEVKNRFEIRLKNERAYYAV
                     RDLLVYDNPEHTAFKIINRYIRFVDKDDSKPRSDWKLNEEWAWFIGNNRERLKLTTKP
                     EPYSFQRTLNWLSHQVAPTLKVAIKLDEINQTQVVKDILDHAKLTDRHKQILKQQSVK
                     EQDVITTKK"
     gene            4324..4545
                     /locus_tag="VVR18_002297"
     CDS             4324..4545
                     /locus_tag="VVR18_002297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU6033709.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            4662..5159
                     /locus_tag="VVR18_002298"
     CDS             4662..5159
                     /locus_tag="VVR18_002298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HEU6033710.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            5134..5640
                     /locus_tag="VVR18_002299"
     CDS             5134..5640
                     /locus_tag="VVR18_002299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016897981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6033711.1"
                     /translation="MGFLKSSIKSVGTLLLADFLFYGVAQSATPIFYERIDYMKKIRS
                     YTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAVMILGNLPPLSMIEGAFLKYF
                     GIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTYAGKKVTLGRNQPQEAITAVR
                     SEFYGISN"
     gene            5624..8071
                     /locus_tag="VVR18_002300"
     CDS             5624..8071
                     /locus_tag="VVR18_002300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU6033712.1"
                     /translation="MAYPIKYIENNLVWNKDGECYAYYELVPYNYSFLSPEQKIQVHD
                     SFRQLIAQNRDGKIHALQISTESSIRSAQERSKNEVTGKLKAVAYDKIDQQTDALISM
                     IGENQVNYRFFIGFKLLLNDQEFSMKSLTVEAKNALSDFVYDVNHKLMGDFVSMSNDE
                     ILRFQKMEKLLENKISRRFKIRRLDKDDFGYLIEHLYGQTGTAYEEYEYHLSKKKLDN
                     ETLIKYYDLIKPTRCLVEEKQRYLKIQQEDETVYVAYFTINSIVGELDFPSSEIFYYQ
                     QQQFTFPIDTSMNVEIVANRKALSTVRNKKKELKDLDNHAWQSDNETSSNVAEALESV
                     NELETNLDQSKESMYKLSYVVRVSANDLDELKRRCNEVKDFYDDLSVKLVRPFGDMLG
                     LHEEFLPASKRYMNDYIQYVTSDFLAGLGFGATQMLGENEGIYVGYSLDTGRNVYLKP
                     ALASQGVKGSVTNALASAFVGSLGGGKSFANNLIVYYAVLYGAQAVIVDPKAERGRWK
                     ETLPEISHEINIVTLTSDEKNKGLLDPYVIMKNPKDSESLAIDILTFLTGISSRDGER
                     FPILRKAIRAVTNSEVRGLMKVIEELRVENTPLSTSIADHIESFTDYDFAHLLFSNGY
                     VEQSISLEKQLNIIQVADLVLPDKETSFEEYTTMELLSVAMLIVISTFALDFIHTDRS
                     IFKIVDLDEAWSFLQVAQGKTLSMKLVRAGRAMNAGVYFVTQNTDDLLDEKLKNNLGL
                     KFAFRSTDLNEIKKTLAFFGVDPEDENNQKRLRDLENGQCLISDLYGRVGVIQFHPVF
                     EELLHAFDTRPPVRKEV"
     gene            8074..10251
                     /locus_tag="VVR18_002301"
     CDS             8074..10251
                     /locus_tag="VVR18_002301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEU6033713.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYDPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            10248..11249
                     /locus_tag="VVR18_002302"
     CDS             10248..11249
                     /locus_tag="VVR18_002302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HEU6033714.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            11246..12178
                     /locus_tag="VVR18_002303"
     CDS             11246..12178
                     /locus_tag="VVR18_002303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU6033715.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYKVNPHKKVVIALWVL
                     LGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKSI
                     DNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQL
                     ITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSIT
                     TNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVTV
                     SLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            12423..12539
                     /locus_tag="VVR18_002304"
     CDS             12423..12539
                     /locus_tag="VVR18_002304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance determinant leader
                     peptide"
                     /protein_id="HEU6033716.1"
                     /translation="MILKYPENICMLCMPMVMHKNPSDKSIYHWDFYALLGF"
     gene            12555..14474
                     /gene="tet(M)"
                     /locus_tag="VVR18_002305"
     CDS             12555..14474
                     /gene="tet(M)"
                     /locus_tag="VVR18_002305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HEU6033717.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDYLLEKYMSGKSLEALELEQEESIRFQNCSLFPLYH
                     GSAKSNIGIDNLIEVITNKFYSSTHRGPSELCGNVFKIEYTKKRQRLAYIRLYSGVLH
                     LRDSVRVSEKEKIKVTEMYTSINGELCKIDRAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRKKIENPHPLLQTTVEPSKPEQREMLLDALLEISDSDPLLRYYVDSTTHEIILSFLG
                     KVQMEVISALLQEKYHVEIELKEPTVIYMERPLKNAEYTIHIEVPPNPFWASIGLSVS
                     PLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
     gene            14593..14760
                     /locus_tag="VVR18_002306"
     CDS             14593..14760
                     /locus_tag="VVR18_002306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002319681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich KTR domain-containing protein"
                     /protein_id="HEU6033718.1"
                     /translation="MCPVCGNKTRLKIREDTELKKFPLYCPKCRQENLIEIKQFKVTV
                     ITEPDAKTQSR"
     gene            complement(14820..15173)
                     /locus_tag="VVR18_002307"
     CDS             complement(14820..15173)
                     /locus_tag="VVR18_002307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU6033719.1"
                     /translation="MRKKEDKYDFRAFGLAIKEARLKRGLTREQVGALIEIDPRYLTN
                     IENKGQHPSIQVLYDLVSLLHVSVDEFFLPANNLVKSTRRLQIEKYMDSFTDKELSLM
                     ESLASGINEARNIED"
BASE COUNT         5044 a         2779 c         3228 g         4498 t
ORIGIN      
        1 agtttgttaa aagtaataaa cggcattatt cccgaatatg attgtggaga tgtaaaagga
       61 gatgttttat acaaggacaa atctttatta gggatgagta tattagaacg atccaagttt
      121 atatctacag tgtttcaaaa tcctaaaaca cagttttatt gtatcaattc cacagatgaa
      181 ttggcttttc aattagaaaa tagatgtata gaaagaaatt taattttaga taaaatacac
      241 tattattcag atgttttagg tagtaaagat ttgttagaca agaatatttt tgaactgtcc
      301 ggtggagaga agcagttaat tgctataact gctagtggaa tttcagaaaa tgaaattatt
      361 cttttagatg aaccatcttc atctttggat tatgaatcaa ttaagaactt aaaaagagct
      421 attattgagc taaaaatagc ataaaaatct agttatccgc ataaaaactg gacttatcac
      481 actttatcaa ggtcaaaacc actcaattta ctactaattt actacttatg aatgagcttt
      541 gatacgacga tttatccttg aaaagtgaag atataaagat acttccaata aaatttgaat
      601 atttaatagg tagacacttc aaaaaatgag gtgtctattt ttttacccga ttttgaaagg
      661 aagtgaactt atgaaaacaa aaaatcaaga atcaaaaggt cgttccccac tctttaagac
      721 catcaaacat tcattcagcc aataaaaaag aaaggatagg taaaaatatg gaacttaaat
      781 ttgtgattcc caacatggaa aaaacattcg gcaatttaga atttgctggc gaggataaag
      841 tcgttcagcg aagaatcaac ggacggctaa ctgtcttatc aagaagctat aatctctatt
      901 ctgatgttca aagagcagat gatattgtgg tggtgcttcc tgctgaagct ggcgaaaaac
      961 atttcggctt tgaggaacgt gtgaagttag tcaatccacg tattaccgca gagggctaca
     1021 aaatcggcac tcgtggtttt acaaattacc ttttacatgc tgacgacatg ataaaagaat
     1081 aaagaaagag aggaaaaatg atgagattag caaatggcat tgtattagat aaagacacga
     1141 cttttggaga attgaaattc tctgctctac gtcgtgaagt gagaatccaa aatgaagacg
     1201 ggtcggtttc agatgaaatc aaggaacgta cctatgactt aaaatccaaa ggacaaggac
     1261 gcatgattca agtaagtatt cctgccagcg tgcctttgaa agagtttgat tataacgcac
     1321 gggtggaact tatcaatccc attgcggaca ccgttgctac tgccacctat caaggagcag
     1381 atgttgactg gtatatcaag gcagacgata ttgtgctgac aaaggattct agttcattca
     1441 aagctcaacc acaagcaaag aaagaaccga cacaagacaa atagtcgcta ggtagaaagg
     1501 agactttttc gcatgaaaca gcgtggtaaa aggattcgcc catctggtaa agatttagtc
     1561 tttcatttta cgatagcgtc actcctgcct gttttcctgc tggttgtcgg actgtttcat
     1621 gtgaagacaa tccagcagat caactggcag gattttaacc tatcacaagc agataagatt
     1681 gacattccct atttaattat cagtttcagt gtcgcaattc ttatctgctt gctggtagcg
     1741 tttgtattca aacgggttcg ctatgatacg gttaaacaac tttaccaccg tcaaaaactg
     1801 gcaaagatga tacttgaaaa caagtggtat gaatctgaac aggtcaaaac agagggtttc
     1861 tttaaagata gtgctggtcg tacaaaggaa aagataacct acttccctaa aatgtattat
     1921 cgacttaaaa atggcttgat acagatacgg gtggaaatca cgctgggaaa atatcaagac
     1981 caactcttac acttggaaaa gaaattagag agtggcttgt actgtgagct gacggataaa
     2041 gagttaaagg attcctatgt ggaatatact ttgctctatg acaccatagc cagtcgtatt
     2101 tctattgatg aagtagaagc taaagatggt aaacttcgct taatgaaaaa cgtatggtgg
     2161 gaatatgata agctccctca tatgttgatt gctggtggta caggtggcgg taaaacttac
     2221 tttatactga cactgattga agccttgctt catacagatt caaaactgta tattcttgac
     2281 ccgaaaaatg ctgatcttgc ggacttaggt tctgtgatgg caaatgtcta ctatagaaaa
     2341 gaagacttgc tttcttgcat tgaaacattc tatgaagaaa tgatgaaacg tagtgaggaa
     2401 atgaagcaga tgaagaacta taagactggc aaaaattatg cttacttagg tctcccggca
     2461 cacttcttaa tctttgatga atacgtcgct ttcatggaaa tgctgggaac aaaagaaaac
     2521 accgcagtta tgaataagct gaaacagatt gtcatgttag gtcgtcaagc tggcttcttt
     2581 ctaatactgg cttgtcaacg tccagacgca aaatatttag gcgacggaat ccgtgatcag
     2641 tttaatttca gagtggcttt aggtcgtatg tctgaaatgg gctatggcat gatgtttggc
     2701 agtgacgtac aaaaggattt cttcttaaag cgaatcaaag gtcgtggcta tgttgatgta
     2761 ggaacaagtg tcatatcaga gttttatact ccccttgtac caaaaggata tgatttcttg
     2821 gaggaaatta aaaagttatc caacagcaga cagtccacgc aggcgacgtg cgaagcggaa
     2881 gtcgcaggtg tggactgatc ttgctggctg gtgtggcaat agccacgcca gcacttaacc
     2941 ccccgtatct aacagggggg tacaaatcga caggaaacag tcaaaaaaac attagaaaat
     3001 cctttggtta caagggattt acaaaatttc agcgtatgtc aaatgggctt taaaagttga
     3061 catacgcctt tttgattgga gggattttta ctgaatgaac aaacttggtt acagcattta
     3121 aaagaaaaac gcttggctta tggactatct caaaaccgtt tagctgttgc gactggtatt
     3181 acaaggcagt atctaagcga tattgaaaca ggaaaagtca agccatcaga ggatttacag
     3241 cagtcccttt gggaagctct ggaacgcttc aatcccgacg ctccccttga aatgctgttt
     3301 gattatgtaa gaattcgctt tccgacaaca gacgtacagc aggtggtcga aaacatctta
     3361 caactgaaac tgtcctattt tcttcatgag gactatggtt tctattctta ttcagagcat
     3421 tatgctttag gcgacatatt cgtcctttgc tcccatgaac tggacaaagg agttctggtg
     3481 gaattgaaag gtcgtgggtg cagacaattt gaaagctatc ttctggcaca acaaagaagc
     3541 tggtatgagt tctttatgga cgttttggtg gctggcggtg tgatgaaacg ccttgacctt
     3601 gccattaacg ataagacagg gattttaaat atccctgtac tcactgaaaa gtgccaacag
     3661 gaagaatgta tctccgtctt ccgcagtttt aaaagctatc gcagtggcga actggtacgc
     3721 aaagaggaaa aggaatgtat gggaaacacc ctctatatcg gttcattaca aagtgaagtt
     3781 tatttctgta tctatgaaaa ggactacgag cagtacaaga aaaatgatat tcccattgaa
     3841 gacgcagaag taaaaaaccg ttttgagatt cgattgaaaa atgagcgtgc ctattatgca
     3901 gtccgtgatt tactcgtcta tgacaatcca gagcataccg cctttaaaat tatcaatcgg
     3961 tatatccgtt ttgtagataa agacgattcc aaacctcgtt ctgattggaa actgaatgaa
     4021 gaatgggctt ggtttattgg gaacaatcgt gaacgattaa aactaaccac aaaaccagag
     4081 ccttactcct tccaaaggac gctgaactgg ctatctcatc aagttgcccc gaccttaaag
     4141 gttgcgatta aacttgatga aatcaaccag acgcaggttg taaaagacat tctcgaccat
     4201 gcgaaactga cagaccgaca caagcagatt ttgaagcaac agtcagtaaa agaacaggac
     4261 gtgataacaa caaaaaaata actcaaatac aaattcattg aatatagaga ggagaacatt
     4321 tttatgaatt ttggacaaaa cctttataac tggtttctat caaacgctca atcactggtg
     4381 cttttagcaa tcgttgtgat tggcttgtat cttggcttca agcgtgagtt tagcaaactg
     4441 attggctttt taattattgc gattattgcg gttggcttag tcttcaacgc tgctggagta
     4501 aaagacattt tactagagct attcaatcgc attattggtg cttaaataaa accgttcttt
     4561 tgtggaatat aagtggtttt cttatgttcc gcaaaggaat ggtacaccaa acgaagtgcg
     4621 gtagggattt ttgaatctct acaaagaaag gacgtgaata tatggacgat atgcaagtct
     4681 atattgcgaa tttaggcaaa tacaatgagg gcgaattggt cggtgcgtgg tttacctttc
     4741 ccattgactt tgaggaagtc aaagagaaaa tcggcttgaa tgatgaatat gaggaatacg
     4801 ccattcatga ctacgagtta ccctttacgg ttgacgaata cacttccatt ggcgaactca
     4861 atcgactatg ggaaatggta tcggaattac ccgaagaatt acaatcggag ctatctgctc
     4921 tgctcactca tttttcaagc attgaagaac taagcgaaca tcaagaggat attatcattc
     4981 attccgattg tgatgatatg tatgacgtgg cacgctacta cattgaagaa acgggtgctt
     5041 taggcgaagt accagctagt cttcaaaact atattgatta tcaagcctat ggtcgggatt
     5101 tagacctttc aggaacgttt atctcaacca atcatgggat ttttgaaatc gtctattaaa
     5161 tctgtcggta cattactact ggcagatttt ctattttacg gggtggctca atcagctacc
     5221 cctatttttt atgaaaggat tgattacatg aagaaaatac gaagctatac cagtatctgg
     5281 tctgtggaaa aggtactgta ttctatcaat gattttagac ttccgtttcc cataaccttt
     5341 acgcaaatga catggtttgt cgtgtcactc tttgcagtga tgatacttgg caacttgccc
     5401 cctctttcca tgatagaggg agcatttctc aaatactttg ggattcctgt ggctttcaca
     5461 tggtttatgt ctacaaaaac ttttgatggt aaaaagcctt atggattttt gaagtctgtc
     5521 attgcttatg cactgcgacc aaagctgacc tatgcaggaa aaaaagtaac gcttggcaga
     5581 aaccagccac aagaagccat tacagcagtt aggagtgaat tttatggcat atccaattaa
     5641 atacattgaa aacaatctcg tctggaataa agacggggaa tgttatgctt actatgagct
     5701 tgttccttac aattactcat ttctaagtcc agaacagaaa atacaagtgc atgattcttt
     5761 cagacagctt atcgcacaaa atcgtgatgg caaaattcat gctttacaaa tcagtacaga
     5821 atccagcata cgttctgcac aagagcgttc caaaaatgaa gtcactggca agctcaaagc
     5881 ggttgcctat gacaaaatcg accaacagac agacgcttta atatccatga ttggcgaaaa
     5941 tcaagtgaac taccgtttct ttatcggctt taagttgctt ctcaacgatc aggagttttc
     6001 tatgaaaagt cttaccgttg aagcaaaaaa tgctttgtct gattttgtct atgatgtgaa
     6061 ccataagctg atgggcgatt ttgttagtat gagtaatgat gaaatcctgc gttttcagaa
     6121 gatggaaaag ctcttagaaa ataaaatctc tcgtcgtttc aaaatccgca ggttagataa
     6181 ggacgacttc ggctatctga ttgaacacct ttacggacag acaggcactg cctatgaaga
     6241 gtatgagtac catctatcaa agaaaaagct ggataatgaa acgctgatta aatactatga
     6301 cttgattaag cctactcgct gtttggtgga agaaaaacag cgatatttga aaatccagca
     6361 ggaagatgaa accgtctatg tagcttactt taccattaac agcattgtcg gagaactgga
     6421 cttcccgtcc tctgaaatct tctactacca gcaacagcaa tttacattcc cgattgatac
     6481 gtcaatgaat gtggaaattg tagcgaatcg taaagcccta tctactgtcc gcaataaaaa
     6541 gaaagaactg aaagacttgg ataaccacgc ttggcaaagt gataatgaaa ccagctccaa
     6601 tgtggcggaa gctctggaaa gtgtgaatga gctggaaacc aatttagacc aaagcaagga
     6661 atctatgtac aagctgtctt atgtggtaag ggtatcagca aatgatcttg acgaactcaa
     6721 acgtcgttgt aatgaagtga aagattttta tgacgattta agcgtaaaac tggtacgacc
     6781 atttggggat atgctcggct tacatgaaga atttttacct gccagcaagc gttatatgaa
     6841 tgattatatt caatacgtga cctctgattt cctcgctggt ttaggttttg gtgctactca
     6901 aatgctgggg gaaaatgagg ggatttatgt tggctacagc ttagatactg gacgcaatgt
     6961 ctatctgaaa cctgctcttg ccagtcaagg ggttaagggt tcagtaacca atgcgttagc
     7021 gtcggctttt gttggttcgc tgggtggtgg taaatccttt gcgaataacc ttatcgtcta
     7081 ttatgcggtg ctttatgggg cacaagcagt gattgtagac ccaaaagcag aacgtggcag
     7141 atggaaagaa accttgccag agatttccca tgaaatcaat atcgtcactc tgacttctga
     7201 tgagaaaaac aaaggcttac ttgaccctta tgtgattatg aaaaatccca aagattctga
     7261 atcactggct attgatattc tgacattcct tacggggatt tcctctcgtg atggggaacg
     7321 cttcccaatc cttagaaaag ccattcgtgc agtaaccaat agtgaagtac gagggttgat
     7381 gaaagtgatt gaggaattac gggttgagaa tacgccacta agtaccagta tagccgacca
     7441 tatcgaaagt tttacagact atgactttgc acatttatta ttcagtaatg gttatgtgga
     7501 gcagtctatc agcttagaaa aacaactgaa cattatacag gttgcggact tggtacttcc
     7561 cgacaaggaa acttcctttg aggaatatac cactatggag cttttatccg ttgctatgct
     7621 gattgtcatt agtacctttg ctttagactt tatccataca gaccgaagca ttttcaagat
     7681 tgtagattta gacgaagcat ggagcttttt acaggtagca caaggaaaaa cactatctat
     7741 gaagctggtt cgggctggtc gtgctatgaa cgctggggta tatttcgtga cccaaaatac
     7801 agacgacctc ttagatgaaa aactgaaaaa taacctcggc ttaaaatttg catttcgttc
     7861 cactgacctt aacgagatta aaaagacctt agcctttttt ggtgtagacc cagaggacga
     7921 aaacaatcag aagcgattgc gtgatttgga aaacgggcaa tgccttatca gtgatttata
     7981 tggtcgtgtc ggtgtgatac agttccaccc tgtatttgaa gaactgctcc atgcctttga
     8041 taccagacca cctgtgcgaa aagaggtgta aatgtgaaac catcaatagt aaacagaata
     8101 aaatcaaact ggacgctgaa acgtctaggt aaagtggcaa tgacagtggc tttcacactt
     8161 gtgattgcca tttttctttt agccatgctg ggaacggtgg ttcaagctgc gggcttggta
     8221 gatgatacgg tcaatgtggc aaatgaatac agccgatacc cacttgaaaa ctatcaactg
     8281 gatttttatg tggataatag ctggggctgg cttccgtgga actggtcgga cgggattgga
     8341 aaacaggtca tgtatggact atatgccatt accaatttta tttggacaat cagtttgtat
     8401 gtttccaatg cgacaggtta cttagtacag gaagcctatt ccttagactt catttccgct
     8461 acagcagatt ccattggtaa gaatatgcag accttagctg gtgtgagtgc aaacggattt
     8521 tcaacagagg gtttctatgt tggattcctc ttactcttga ttttggttct tggggtttat
     8581 gttgcctata cgggactgat aaagagagaa accacaaagg caattcatgc cattatgaat
     8641 tttgtgctgg tgtttatcct atcggcttcc tttattgcct acgatcccga ctacattaaa
     8701 aaaatcaatg acttttcatc agacatcagt aatgccagtt tatcacttgg cacgaagatt
     8761 gtcatgcccc attccgatag tcaaggcaag gacagcgtgg acttaatcag agatagcctg
     8821 ttttccatac aggttcagca accgtggcta ctgcttcaat acaacagttc agacattgaa
     8881 agtatcggta ttgaccgtgt ggaaagcctg ctctccacca gcccagattc caacaatggc
     8941 gaagatagag aaaaaattgt tgcggaagaa attgaagaca gaagcaatac caatctaacc
     9001 attacaaaga ccattaaccg tttaggtaca gtcttcttcc tatttgtctt caatattggg
     9061 atttccatat ttgtattcct attaacagga atcatgattt tctcgcaggt actttttatc
     9121 atctatgcta tgtttctgcc tgtgagcttt attttaagca tgattccatc atttgatggt
     9181 atgtcaaaac gagccataac aaagctcttt aataccattt tgacacgagc tggaatcaca
     9241 ttgattatta cgacagcatt tagtatttca accatgctct ataccttatc ggctggttat
     9301 ccgttctttt tgattgcttt tctacagatt gtgacctttg caggaatcta cttcaagctg
     9361 ggcgatttaa tgagtatgtt ttctctacag agtaacgatt ctcaaagtgt gggaagtcgt
     9421 gtgatgagaa aacctcgtat gcttatgcac gctcacatgc accgtctaca gcggaaactt
     9481 ggacgttcca tgactactct aggggctggg tctgccattg ttacaggtaa aaaaggacag
     9541 tcgggttcgg ggagttctgc aaggacacaa gcagatcact cccgaccaga cggaaaggaa
     9601 aaatcaacac ttggaaaacg tatcggtcaa accatcggta cagtagctga taccaaagac
     9661 agaatggtag acactgctag tggtttgaaa gaacaggtta aagatttgcc gaccaatgca
     9721 agatatgcag tatatcaagg aaaatccaaa gtaaaagaga atgtccgtga tttaaccagt
     9781 agtatttctc aaaccaaagc ggacagagcc agtggacgca aggaacagca ggaacaaagg
     9841 cgaaaaacca ttgcgaagcg tcgctctgaa atggaacagg tcaaacagaa aaaacagcct
     9901 gcttcttctg ttcatgaaag accgactaca agacaagaac aatatcatga tgaacagacc
     9961 tcaaaacagt ctaatattca gacttcatat aaggaatctc aacaagccaa acaagagcgt
    10021 ccagcagtta agtccgattt ttcaagtcca aaagtggaac gccaaggcaa taccgttcaa
    10081 gaaaaaaccg ttcaaaagcc agcaacttca accactacag cagatagaac ttcacaacgt
    10141 ccaatcacaa aagaacgtcc gtctactgtt caaagagtac cactacaaaa tacaagaagt
    10201 agaccaccaa tcaaaaccgc caccattaag aaagtcggta agaaaccatg aagttgaaaa
    10261 ctttagtgat tggtggttct ggattattct tgatggtctt ctcactgctt ctgtttgttg
    10321 ccattttatt ttcagatgaa caggacagcg gaatttccaa tattcattat ggaggtgtga
    10381 atgtttccgc agaagtgctg gctcataagc ctatggtaga aaaatatgcc aaagaatatg
    10441 gcgttgaaga atatgtcaac atacttcttg cgattataca ggtggaatcg ggcggtactg
    10501 cggaagatgt tatgcagtcc tcggaatccc tcggtcttcc acctaattca ttgagtacag
    10561 aagaatccat taagcaaggt gtgaagtatt tcagtgaatt attagccagt agcgaaaggc
    10621 tcagtgtaga tttagaatcg gttatccagt cctacaatta tggtggtggt ttcttagggt
    10681 atgtggctaa tcgtggaaat aaatatacct ttgaactggc tcaaagtttc tcaaaagagt
    10741 attcaggtgg cgaaaaagtg tcttacccca atcccatagc catacctatc aatgggggct
    10801 ggcgatacaa ctatggcaat atgttttatg tgcaactggt aacgcagtat cttgtcacaa
    10861 cagagtttga tgatgatacg gtacaagcca tcatggacga agcactgaaa tatgagggct
    10921 ggcgatacgt ttacggtgga gcttccccga ctacttcttt tgattgtagc ggactgacac
    10981 aatggacgta tggaaaagct ggaattaact taccacgaac cgcacaacag caatatgatg
    11041 tgacccagca tatcccacta tcggaagcac aagctggcga tttggttttc tttcattcta
    11101 cctataacgc tggctcttat attactcatg ttgggatata ccttggcaat aaccgtatgt
    11161 ttcatgcagg cgacccaatc ggttatgccg acttaacaag cccctactgg caacagcatt
    11221 tagtgggagc aggacgaatc aaacaatgag aaaggaagat ttaatgatga aatttagaaa
    11281 aaatcagaat aaagaaaaac agataccaaa ggaaaagaaa cctcgtgtct ataaggtcaa
    11341 tcctcataaa aaggttgtga ttgccttgtg ggtactttta gggcttagtt tcagctttgc
    11401 gatattcaag cactttacag ctatagatac tcatactatt cacgaaacaa ctatcataga
    11461 aaaggaatac gttgatactc atcatgtaga aaattttgta gagaactttg cgaaagtcta
    11521 ctattcatgg gagcaatccg ataagtccat tgataatcga atggaaagtc taaaaggcta
    11581 tctgacagat gaacttcaag ctctcaatgt tgatacagta cgcaaagata ttcctgtatc
    11641 gtcttctgta agaggatttc agatatggac ggtagagcca actggcgaca atgagtttaa
    11701 tgtaacctac agtgtagacc agctcattac agagggagaa aatacaaaga ccgtccactc
    11761 tgcttatata gtgagtgtct atgtagatgg ttctggaaat atggtactgg ttaagaatcc
    11821 gaccattacc aacataccta agaaatcaag ttataaacca aaagccattg aaagtgaggg
    11881 gacggttgat tccattacaa ccaatgaaat caatgagttt ttaacgacgt tcttcaagct
    11941 ctatcctaca gcgacagcca gtgaactttc ctactatgtg aatgacggga tattaaaacc
    12001 aatcggaaaa gagtacatct ttcaagaact ggtaaatcct attcacaatc gtaaggataa
    12061 tcaagtcacg gtatcgctga cagtggagta tatcgaccag cagaccaaag caacgcaggt
    12121 atctcaattt gatttggtac ttgaaaagaa cgggagtaat tggaagatta tagaataaca
    12181 aatattggta cattattaca gctattttgt aatcacgtac tctctttgat aaaaaattgg
    12241 agattccttt acaaatatgc tcttacgtgc tattatttaa gtatctattt aaaaggagtt
    12301 aataaatatg cggcaaggta ttcttaaata aactgtcaat ttgatagtgg gaacaaataa
    12361 ttggatgtcc ttttttagga gggcttagtt ttttgtaccc agtttaagaa tacctttatc
    12421 atgtgattct aaagtatccg gagaatatct gtatgctttg tatgcctatg gttatgcata
    12481 aaaatcccag tgataaaagt atttatcact gggattttta tgcccttttg ggtttttgaa
    12541 tggaggaaaa tcacatgaaa attattaata ttggagtttt agctcatgtt gatgcaggaa
    12601 aaactacctt aacagaaagc ttattatata acagtggagc gattacagaa ttaggaagcg
    12661 tggacaaagg tacaacgagg acggataata cgcttttaga acgtcagaga ggaattacaa
    12721 ttcagacagg aataacctct tttcagtggg aaaatacgaa ggtgaacatc atagacacgc
    12781 caggacatat ggatttctta gcagaagtat atcgttcatt atcagtttta gatggggcaa
    12841 ttctactgat ttctgcaaaa gatggcgtac aagcacaaac tcgtatatta tttcatgcac
    12901 ttaggaaaat ggggattccc acaatctttt ttatcaataa gattgaccaa aatggaattg
    12961 atttatcaac ggtttatcag gatattaaag agaaactttc tgccgaaatt gtaatcaaac
    13021 agaaggtaga actgtatcct aatatgtgtg tgacgaactt taccgaatct gaacaatggg
    13081 atacggtaat agagggaaac gattaccttt tagagaaata tatgtccggt aaatcattag
    13141 aagcattgga actcgaacaa gaggaaagca taagatttca gaattgttct ctgttccctc
    13201 tttatcatgg aagtgcaaaa agtaatatag ggattgataa ccttatagaa gttattacta
    13261 ataaatttta ttcatcaaca catcgaggtc cgtctgaact ttgcggaaat gttttcaaaa
    13321 ttgaatatac aaaaaaaaga caacgtcttg catatatacg cctttatagt ggagtactac
    13381 atttacgaga ttcggttaga gtatcagaaa aagaaaaaat aaaagttaca gaaatgtata
    13441 cttcaataaa tggtgaatta tgtaagattg atagagctta ttctggagaa attgttattt
    13501 tgcaaaatga gtttttgaag ttaaatagtg ttcttggaga tacaaaacta ttgccacaga
    13561 gaaaaaagat tgaaaatccg caccctctac tacaaacaac tgttgaaccg agtaaacctg
    13621 aacagagaga aatgttgctt gatgcccttt tggaaatctc agatagtgat ccgcttctac
    13681 gatattacgt ggattctacg acacatgaaa ttatactttc tttcttaggg aaagtacaaa
    13741 tggaagtgat tagtgcactg ttgcaagaaa agtatcatgt ggagatagaa ctaaaagagc
    13801 ctacagtcat ttatatggag agaccgttaa aaaatgcaga atataccatt cacatcgaag
    13861 tgccgccaaa tcctttctgg gcttccattg gtttatctgt atcaccgctt ccgttgggaa
    13921 gtggaatgca gtatgagagc tcggtttctc ttggatactt aaatcaatcg tttcaaaatg
    13981 cagttatgga ggggatacgc tatggctgtg aacaaggatt gtatggttgg aatgtgacgg
    14041 actgtaaaat ctgttttaag tatggcttat actatagccc tgttagtacc ccagcagatt
    14101 ttcggatgct tgctcctatt gtattggaac aagtcttaaa aaaagctgga acagaattgt
    14161 tagagccata tcttagtttt aaaatttatg cgccacagga atatctttca cgagcataca
    14221 acgatgctcc taaatattgt gcgaacatcg tagacactca attgaaaaat aatgaggtca
    14281 ttcttagtgg agaaatccct gctcggtgta ttcaagaata tcgtagtgat ttaactttct
    14341 ttacaaatgg acgtagtgtt tgtttaacag agttaaaagg gtaccatgtt actaccggtg
    14401 aacctgtttg ccagccccgt cgtccaaata gtcggataga taaagtacga tatatgttca
    14461 ataaaataac ttagtgtatt ttatgttgtt atataaatat ggtttcttgt taaataagat
    14521 gaaatatttt ttaataaaga tttgaattaa agtgtaaagg aggagatagt tattataaac
    14581 tacaagtgga tattgtgtcc tgtatgtgga aataaaacac gattaaagat aagggaagat
    14641 actgaattaa aaaaattccc cctctattgt ccgaaatgca gacaagaaaa tttaattgaa
    14701 ataaagcagt tcaaagtaac tgtgattaca gagccagacg caaagacgca gagccgataa
    14761 aatgagatta atacaatctc attttatcgg ctctttccgt tatgtatgga ttcttttaat
    14821 tagtcttcga tgtttcttgc ttcgttgata ccgctggcta aagattccat taaggatagt
    14881 tctttgtctg taaagctatc catgtatttc tctatctgta atcgtcgggt gctttttacc
    14941 aagttattag caggtaagaa aaattcatca acggaaacat gaagtaacga tacaaggtca
    15001 taaagaactt gtatgctggg gtgttgccct ttattttcaa tattagttaa gtaccgtggg
    15061 tcaatttcaa tcaatgctcc cacttgttca cgagttaaac ctcgtttcaa tcgagcttct
    15121 ttaatggcta aaccaaaggc tctaaaatca tatttatctt cttttttacg catagtagac
    15181 cacctctata cattttattg ttcctactga attaaaaaca ggtatagaaa aacgtgttat
    15241 atggtttata ggtttatatt taataaaaag cactactaaa cgccaataaa aaaaaccgtt
    15301 atatggtagt gctatttacg ctgttaaaat attgtatatt acttccaaat ggcggtttgt
    15361 tggaggtcaa cgtcgccatg aagtacatca tatacaataa atttccttac attgggttct
    15421 tgtcaaaaaa agtcgtctat ctgcaataga taagtacgtc caccaatgtg gttttataaa
    15481 tcatatagat agaataacag aagcatgtaa acagagaaat aaatctgttt atatgctttt
    15541 ttggctatt
//
LOCUS       DAVHSO010000161          931 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae strain Streptococcus species
            isolate Cambodian child SAMN04254706-rid19266893.guided.141, whole
            genome shotgun sequence.
ACCESSION   DAVHSO010000161 DAVHSO010000000
VERSION     DAVHSO010000161.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04254706
            Sequence Read Archive: SRR2912551
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 931)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 931)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001866616.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001866616.1
            Genome Coverage       :: 178x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/29/2023 02:42:12
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,308
            CDSs (total)                      :: 2,262
            Genes (coding)                    :: 2,107
            CDSs (with protein)               :: 2,107
            Genes (RNA)                       :: 46
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 40
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 72 of 155
            Pseudo Genes (incomplete)         :: 74 of 155
            Pseudo Genes (internal stop)      :: 44 of 155
            Pseudo Genes (multiple problems)  :: 28 of 155
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04254706-rid19266893.guided.141"
                     /strain="Streptococcus species"
                     /serotype="5"
                     /isolate="Cambodian child"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Cambodia"
                     /lat_lon="13.21 N 103.51 E"
                     /collection_date="2011-06-16"
                     /collected_by="Catrin Moore"
     gene            307..735
                     /locus_tag="VVR18_002308"
     CDS             307..735
                     /locus_tag="VVR18_002308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU6033720.1"
                     /translation="MDGITKDFIKTAKLMKQLWPQLTDKEAIDEVKKYTNGKNTAIFT
                     EVEGDTIVGLALCSLRFDYVEGCKYSPVGFLEGIIVDEEYRLKDIAKNLCTKCEEWAK
                     NKGCKEFASDCTLTNTDSIRFHLNIGFQEANRIIHFKKKL"
BASE COUNT          343 a          127 c          197 g          264 t
ORIGIN      
        1 atacacacaa ggaaatcatc gccaaactgg actacgacgc accatgttga ggcagtatca
       61 ctgcttgtac aagctgaggc atcagcgaag tagaagtaaa tgatctccca tacgatagga
      121 ctcgtagaat gaggagggaa accgacgaaa tgataaggta agtccgaacc gctgagtgcg
      181 tggctctgct cttccgatct gagacagtcg aaaagtagaa ggggatggta ttggtatcaa
      241 tcaatgagta acaaagtatc agcatgattc gaaacattta cttgtaattt gcggaggaac
      301 atcaatatgg atggaataac aaaagatttt ataaaaacgg ctaaactaat gaaacaatta
      361 tggccccaat tgaccgataa agaagctatt gatgaagtaa aaaaatatac gaatggcaaa
      421 aatactgcaa tctttactga agttgaaggt gacacaattg taggtctagc actatgttca
      481 ctcagatttg attatgttga aggttgtaaa tatagtcctg ttggattctt agaagggatt
      541 attgttgacg aggaatatcg tttaaaggat attgctaaaa atctctgtac aaaatgtgag
      601 gaatgggcga aaaataaagg atgtaaggaa tttgcaagtg actgtacttt aacgaatacg
      661 gattctataa gatttcatct caatattgga tttcaggagg caaatagaat tattcatttt
      721 aagaaaaaat tataatttag aaacgtgaat aaacttgttt aaactttatg tatctttaga
      781 aagtgtgtta acttgaaaga acaaattttt ttgatgggtg ggaatccccc aatgaagaaa
      841 tatagtattg ttgataaaat tgtattatca accaagatta aaagaattat catttttaca
      901 gtttttcgag aaaattggga accgtacatg a
//
